cases: - case_id: SFB_FS_A1AT_1QLPA_1OPHA pattern: fold_switch_metamorphic query_uniprot: P01009 query_pdb: 1QLP query_chain: A query_resi_range: 23..394 query_length: 372 state_a_pdb: 1QLP state_a_chain: A state_b_pdb: 1OPH state_b_chain: A target_state: B expected_pattern_signature: Alpha-1 antitrypsin native serpin <-> cleaved/latent metastable conformation literature_ref: Elliott 1996 Nat Struct Biol source: https://doi.org/10.1038/nsb1196-910 notes: '' qc: n_common_residues: 372 n_common_core_lt3A: 359 n_switch_region_ge3A: 13 core_fraction: 0.965 - case_id: SFB_FS_CLIC1_1K0MA_1K0NA pattern: fold_switch_metamorphic query_uniprot: O00299 query_pdb: 1K0M query_chain: A query_resi_range: 6..240 query_length: 235 state_a_pdb: 1K0M state_a_chain: A state_b_pdb: 1K0N state_b_chain: A target_state: B expected_pattern_signature: CLIC1 soluble GST-fold <-> membrane chloride-channel conformation literature_ref: Littler 2004 J Biol Chem source: https://doi.org/10.1074/jbc.M308444200 notes: '' qc: n_common_residues: 225 n_common_core_lt3A: 220 n_switch_region_ge3A: 5 core_fraction: 0.978 - case_id: SFB_FS_DLC8_2PG1A_1F3CA pattern: fold_switch_metamorphic query_uniprot: P63167 query_pdb: 2PG1 query_chain: A query_resi_range: 5..89 query_length: 85 state_a_pdb: 2PG1 state_a_chain: A state_b_pdb: 1F3C state_b_chain: A target_state: B expected_pattern_signature: DLC8/LC8 dynein light chain dimerization-coupled fold switch literature_ref: Fan 2001 JMB source: https://doi.org/10.1006/jmbi.2001.4953 notes: '' qc: n_common_residues: 85 n_common_core_lt3A: 83 n_switch_region_ge3A: 2 core_fraction: 0.976 - case_id: SFB_FS_GA98GB98_2LHCA_2LHDA pattern: fold_switch_metamorphic query_uniprot: '' query_pdb: 2LHC query_chain: A query_resi_range: 1..56 query_length: 56 state_a_pdb: 2LHC state_a_chain: A state_b_pdb: 2LHD state_b_chain: A target_state: B expected_pattern_signature: 'GA98/GB98 engineered fold-switch: 3-alpha (GA) <-> 4-beta+alpha (GB)' literature_ref: Alexander 2009 PNAS source: https://doi.org/10.1073/pnas.0905068106 notes: '' qc: n_common_residues: 56 n_common_core_lt3A: 10 n_switch_region_ge3A: 46 core_fraction: 0.179 - case_id: SFB_FS_IscU_1WFZA_2KQKA pattern: fold_switch_metamorphic query_uniprot: P0ACD4 query_pdb: 1WFZ query_chain: A query_resi_range: 1..130 query_length: 130 state_a_pdb: 1WFZ state_a_chain: A state_b_pdb: 2KQK state_b_chain: A target_state: B expected_pattern_signature: IscU disordered (D) <-> structured (S) Fe-S cluster scaffold literature_ref: Kim 2012 PNAS source: https://doi.org/10.1073/pnas.1212358109 notes: '' qc: n_common_residues: 128 n_common_core_lt3A: 30 n_switch_region_ge3A: 98 core_fraction: 0.234 - case_id: SFB_FS_KAIA_1R8JA_1R8QA pattern: fold_switch_metamorphic query_uniprot: Q79V62 query_pdb: 1R8J query_chain: A query_resi_range: 1..282 query_length: 272 state_a_pdb: 1R8J state_a_chain: A state_b_pdb: 1R8Q state_b_chain: A target_state: B expected_pattern_signature: KaiA C-terminal domain conformational reshuffling literature_ref: Ye 2004 PNAS source: https://doi.org/10.1073/pnas.0405842101 notes: '' qc: n_common_residues: 169 n_common_core_lt3A: 3 n_switch_region_ge3A: 166 core_fraction: 0.018 - case_id: SFB_FS_KAIB_2QKEB_5JYTA pattern: fold_switch_metamorphic query_uniprot: Q79V61 query_pdb: 2QKE query_chain: B query_resi_range: 5..95 query_length: 91 state_a_pdb: 2QKE state_a_chain: B state_b_pdb: 5JYT state_b_chain: A target_state: B expected_pattern_signature: Thioredoxin-fold <-> KaiB-fold metamorphic switch (circadian clock B-subunit) literature_ref: Chang 2015 Science; Murzin 2008 Science source: https://doi.org/10.1126/science.aaa1374 notes: Reference metamorphic case from AF-Cluster paper qc: n_common_residues: 91 n_common_core_lt3A: 44 n_switch_region_ge3A: 47 core_fraction: 0.484 - case_id: SFB_FS_MAD2_1DUJA_1GO4A pattern: fold_switch_metamorphic query_uniprot: Q13257 query_pdb: 1DUJ query_chain: A query_resi_range: 11..197 query_length: 187 state_a_pdb: 1DUJ state_a_chain: A state_b_pdb: 1GO4 state_b_chain: A target_state: B expected_pattern_signature: MAD2 O-MAD2 (open) <-> C-MAD2 (closed) spindle-checkpoint metamorphic literature_ref: Luo 2004 Nat Struct Mol Biol source: https://doi.org/10.1038/nsmb748 notes: '' qc: n_common_residues: 187 n_common_core_lt3A: 9 n_switch_region_ge3A: 178 core_fraction: 0.048 - case_id: SFB_FS_MPT53_1LU4A_3EMXA pattern: fold_switch_metamorphic query_uniprot: P9WG70 query_pdb: 1LU4 query_chain: A query_resi_range: 1001..1134 query_length: 134 state_a_pdb: 1LU4 state_a_chain: A state_b_pdb: 3EMX state_b_chain: A target_state: B expected_pattern_signature: 'Mpt53 secreted disulfide-isomerase: alternate fold candidate (DALI hit 3EMX, Aeropyrum pernix thioredoxin)' literature_ref: Goulding 2004 J Mol Biol source: https://doi.org/10.1016/j.jmb.2004.05.060 notes: Pair-aligned by positional CA index because 1LU4 (1001..1134) and 3EMX (224..347) share no residue numbers. 3EMX is a DALI hit only; biological metamorphism not proven. qc: n_common_residues: 124 n_common_core_lt3A: 1 n_switch_region_ge3A: 123 core_fraction: 0.008 - case_id: SFB_FS_NTRC2_1NY3A_3DZEA pattern: fold_switch_metamorphic query_uniprot: P0AFB8 query_pdb: 1NY3 query_chain: A query_resi_range: 46..345 query_length: 277 state_a_pdb: 1NY3 state_a_chain: A state_b_pdb: 3DZE state_b_chain: A target_state: B expected_pattern_signature: NtrC receiver domain inactive <-> active fold-switch-like rearrangement literature_ref: Hastings 2008 PNAS source: https://doi.org/10.1073/pnas.0709728105 notes: '' qc: n_common_residues: 124 n_common_core_lt3A: 1 n_switch_region_ge3A: 123 core_fraction: 0.008 - case_id: SFB_FS_NUSG_2K06A_2LQ8A pattern: fold_switch_metamorphic query_uniprot: P0AFG0 query_pdb: 2K06 query_chain: A query_resi_range: 1..123 query_length: 123 state_a_pdb: 2K06 state_a_chain: A state_b_pdb: 2LQ8 state_b_chain: A target_state: B expected_pattern_signature: 'NusG-SP CTD: KOW-fold <-> alpha-hairpin metamorphic' literature_ref: Burmann 2010 Science source: https://doi.org/10.1126/science.1184953 notes: '' qc: n_common_residues: 123 n_common_core_lt3A: 2 n_switch_region_ge3A: 121 core_fraction: 0.016 - case_id: SFB_FS_P13_2I4ZA_4M1EA pattern: fold_switch_metamorphic query_uniprot: Q98DV5 query_pdb: 2I4Z query_chain: A query_resi_range: 207..476 query_length: 270 state_a_pdb: 2I4Z state_a_chain: A state_b_pdb: 4M1E state_b_chain: A target_state: B expected_pattern_signature: p13 metamorphic protein (intracellular signaling) literature_ref: Roessler 2015 JMB source: https://doi.org/10.1016/j.jmb.2014.10.010 notes: '' qc: n_common_residues: 67 n_common_core_lt3A: 3 n_switch_region_ge3A: 64 core_fraction: 0.045 - case_id: SFB_FS_RFAH_5ONDA_6C6SD pattern: fold_switch_metamorphic query_uniprot: P0AFW0 query_pdb: 5OND query_chain: A query_resi_range: 1..155 query_length: 135 state_a_pdb: 5OND state_a_chain: A state_b_pdb: 6C6S state_b_chain: D target_state: B expected_pattern_signature: 'RfaH CTD: alpha-helical hairpin <-> beta-barrel (transcription/translation coupling)' literature_ref: Burmann 2012 Cell; Zuber 2018 Nat Commun source: https://doi.org/10.1038/s41467-019-10918-2 notes: '' qc: n_common_residues: 134 n_common_core_lt3A: 79 n_switch_region_ge3A: 55 core_fraction: 0.59 - case_id: SFB_FS_SELECASE_4QHFA_4QHGA pattern: fold_switch_metamorphic query_uniprot: I3VWL5 query_pdb: 4QHF query_chain: A query_resi_range: 1..109 query_length: 109 state_a_pdb: 4QHF state_a_chain: A state_b_pdb: 4QHG state_b_chain: A target_state: B expected_pattern_signature: Selecase oligomer monomer fold switch (zinc metallopeptidase) literature_ref: Lopez-Pelegrin 2014 Cell Rep source: https://doi.org/10.1016/j.celrep.2014.06.012 notes: '' qc: n_common_residues: 107 n_common_core_lt3A: 99 n_switch_region_ge3A: 8 core_fraction: 0.925 - case_id: SFB_FS_XCL1_1J8IA_2JP1A pattern: fold_switch_metamorphic query_uniprot: P47992 query_pdb: 1J8I query_chain: A query_resi_range: 1..93 query_length: 93 state_a_pdb: 1J8I state_a_chain: A state_b_pdb: 2JP1 state_b_chain: A target_state: B expected_pattern_signature: 'Lymphotactin: chemokine-fold <-> all-beta dimer fold metamorphic switch' literature_ref: Tuinstra 2008 PNAS source: https://doi.org/10.1073/pnas.0711389105 notes: '' qc: n_common_residues: 60 n_common_core_lt3A: 20 n_switch_region_ge3A: 40 core_fraction: 0.333 - case_id: SFB_AL_AKE_4AKEA_1AKEA pattern: allosteric_ligand_induced query_uniprot: P69441 query_pdb: 4AKE query_chain: A query_resi_range: 1..214 query_length: 214 state_a_pdb: 4AKE state_a_chain: A state_b_pdb: 1AKE state_b_chain: A target_state: B expected_pattern_signature: Adenylate kinase open (apo) <-> closed (Ap5A-bound) lid-rearrangement literature_ref: Muller 1992 JMB; Henzler-Wildman 2007 Nature source: https://doi.org/10.1038/nature06407 notes: '' qc: n_common_residues: 214 n_common_core_lt3A: 126 n_switch_region_ge3A: 88 core_fraction: 0.589 - case_id: SFB_AL_CALM_1CFDA_1CLLA pattern: allosteric_ligand_induced query_uniprot: P0DP23 query_pdb: 1CFD query_chain: A query_resi_range: 1..148 query_length: 148 state_a_pdb: 1CFD state_a_chain: A state_b_pdb: 1CLL state_b_chain: A target_state: B expected_pattern_signature: Calmodulin apo (collapsed) <-> Ca2+-bound (extended) conformational switch literature_ref: Kuboniwa 1995 Nat Struct Biol source: https://doi.org/10.1038/nsb0995-768 notes: '' qc: n_common_residues: 144 n_common_core_lt3A: 21 n_switch_region_ge3A: 123 core_fraction: 0.146 - case_id: SFB_AL_CDK6_1BI7A_2EUFB pattern: allosteric_ligand_induced query_uniprot: Q00534 query_pdb: 1BI7 query_chain: A query_resi_range: 10..301 query_length: 269 state_a_pdb: 1BI7 state_a_chain: A state_b_pdb: 2EUF state_b_chain: B target_state: B expected_pattern_signature: CDK6 kinase inactive (p16-bound) <-> active (V-cyclin) literature_ref: Russo 1998 Nat Struct Biol source: https://doi.org/10.1038/sb0498-262 notes: '' qc: n_common_residues: 255 n_common_core_lt3A: 180 n_switch_region_ge3A: 75 core_fraction: 0.706 - case_id: SFB_AL_CHEY_3CHYA_1FQWA pattern: allosteric_ligand_induced query_uniprot: P0AE67 query_pdb: 3CHY query_chain: A query_resi_range: 2..129 query_length: 128 state_a_pdb: 3CHY state_a_chain: A state_b_pdb: 1FQW state_b_chain: A target_state: B expected_pattern_signature: CheY response regulator inactive <-> active (Mg-BeF3 phosphorylated) literature_ref: Lee 2001 Nat Struct Biol source: https://doi.org/10.1038/85661 notes: '' qc: n_common_residues: 128 n_common_core_lt3A: 127 n_switch_region_ge3A: 1 core_fraction: 0.992 - case_id: SFB_AL_DHFR_1RX1A_1RX4A pattern: allosteric_ligand_induced query_uniprot: P0ABQ4 query_pdb: 1RX1 query_chain: A query_resi_range: 1..159 query_length: 159 state_a_pdb: 1RX1 state_a_chain: A state_b_pdb: 1RX4 state_b_chain: A target_state: B expected_pattern_signature: DHFR Met20 loop closed <-> occluded (folate/NADP intermediate) literature_ref: Sawaya 1997 Biochemistry source: https://doi.org/10.1021/bi962337c notes: '' qc: n_common_residues: 159 n_common_core_lt3A: 156 n_switch_region_ge3A: 3 core_fraction: 0.981 - case_id: SFB_AL_EGFR_2GS2A_1XKKA pattern: allosteric_ligand_induced query_uniprot: P00533 query_pdb: 2GS2 query_chain: A query_resi_range: 672..994 query_length: 305 state_a_pdb: 2GS2 state_a_chain: A state_b_pdb: 1XKK state_b_chain: A target_state: B expected_pattern_signature: EGFR kinase inactive (lapatinib) <-> active asymmetric dimer literature_ref: Wood 2004 Cancer Res source: https://doi.org/10.1158/0008-5472.CAN-04-1168 notes: '' qc: n_common_residues: 252 n_common_core_lt3A: 2 n_switch_region_ge3A: 250 core_fraction: 0.008 - case_id: SFB_AL_GLNBP_1GGGA_1WDNA pattern: allosteric_ligand_induced query_uniprot: P0AEQ3 query_pdb: 1GGG query_chain: A query_resi_range: 5..224 query_length: 220 state_a_pdb: 1GGG state_a_chain: A state_b_pdb: 1WDN state_b_chain: A target_state: B expected_pattern_signature: Glutamine-binding protein open (apo) <-> closed (Gln-bound) literature_ref: Hsiao 1996 JMB source: https://doi.org/10.1006/jmbi.1996.0438 notes: '' qc: n_common_residues: 220 n_common_core_lt3A: 131 n_switch_region_ge3A: 89 core_fraction: 0.595 - case_id: SFB_AL_LIVBP_2LIVA_1Z15A pattern: allosteric_ligand_induced query_uniprot: P0AD96 query_pdb: 2LIV query_chain: A query_resi_range: 1..344 query_length: 344 state_a_pdb: 2LIV state_a_chain: A state_b_pdb: 1Z15 state_b_chain: A target_state: B expected_pattern_signature: Leucine/Ile/Val-BP open (apo) <-> closed (Leu-bound) hinge motion literature_ref: Sack 1989 JMB source: https://doi.org/10.1016/0022-2836(89)90342-6 notes: '' qc: n_common_residues: 344 n_common_core_lt3A: 341 n_switch_region_ge3A: 3 core_fraction: 0.991 - case_id: SFB_AL_MBP_1OMPA_1ANFA pattern: allosteric_ligand_induced query_uniprot: P0AEX9 query_pdb: 1OMP query_chain: A query_resi_range: 1..370 query_length: 370 state_a_pdb: 1OMP state_a_chain: A state_b_pdb: 1ANF state_b_chain: A target_state: B expected_pattern_signature: Maltose-binding protein open (apo) <-> closed (maltose-bound) literature_ref: Sharff 1992 Biochemistry source: https://doi.org/10.1021/bi00163a008 notes: '' qc: n_common_residues: 370 n_common_core_lt3A: 223 n_switch_region_ge3A: 147 core_fraction: 0.603 - case_id: SFB_AL_MEK1_3EQIA_3MBLA pattern: allosteric_ligand_induced query_uniprot: Q02750 query_pdb: 3EQI query_chain: A query_resi_range: 39..382 query_length: 315 state_a_pdb: 3EQI state_a_chain: A state_b_pdb: 3MBL state_b_chain: A target_state: B expected_pattern_signature: MEK1 inactive (apo) <-> active (ATP/Mg-bound) DFG flip literature_ref: Fischmann 2009 Biochemistry source: https://doi.org/10.1021/bi900132f notes: '' qc: n_common_residues: 290 n_common_core_lt3A: 281 n_switch_region_ge3A: 9 core_fraction: 0.969 - case_id: SFB_AL_PHOB_1B00A_1ZESA pattern: allosteric_ligand_induced query_uniprot: P0AFJ5 query_pdb: 1B00 query_chain: A query_resi_range: 2..123 query_length: 122 state_a_pdb: 1B00 state_a_chain: A state_b_pdb: 1ZES state_b_chain: A target_state: B expected_pattern_signature: PhoB response-regulator inactive <-> active (BeF3) literature_ref: Bachhawat 2005 Structure source: https://doi.org/10.1016/j.str.2005.04.016 notes: '' qc: n_common_residues: 121 n_common_core_lt3A: 108 n_switch_region_ge3A: 13 core_fraction: 0.893 - case_id: SFB_AL_PKA_1ATPE_2CPKE pattern: allosteric_ligand_induced query_uniprot: P00517 query_pdb: 1ATP query_chain: E query_resi_range: 15..350 query_length: 334 state_a_pdb: 1ATP state_a_chain: E state_b_pdb: 2CPK state_b_chain: E target_state: B expected_pattern_signature: PKA catalytic subunit closed (Mg-ATP-PKI) <-> open (apo) literature_ref: Knighton 1991 Science source: https://doi.org/10.1126/science.1862342 notes: '' qc: n_common_residues: 333 n_common_core_lt3A: 333 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_AL_RAS_4Q21A_5P21A pattern: allosteric_ligand_induced query_uniprot: P01112 query_pdb: 4Q21 query_chain: A query_resi_range: 1..169 query_length: 169 state_a_pdb: 4Q21 state_a_chain: A state_b_pdb: 5P21 state_b_chain: A target_state: B expected_pattern_signature: H-Ras GDP-bound (inactive) <-> GTP-analog (active) Switch I/II literature_ref: Milburn 1990 Science source: https://doi.org/10.1126/science.2406906 notes: '' qc: n_common_residues: 166 n_common_core_lt3A: 156 n_switch_region_ge3A: 10 core_fraction: 0.94 - case_id: SFB_AL_RBP_1URPA_2DRIA pattern: allosteric_ligand_induced query_uniprot: P02925 query_pdb: 1URP query_chain: A query_resi_range: 1..271 query_length: 271 state_a_pdb: 1URP state_a_chain: A state_b_pdb: 2DRI state_b_chain: A target_state: B expected_pattern_signature: Ribose-binding protein open <-> closed sugar-induced lid closure literature_ref: Bjorkman 1994 JMB source: https://doi.org/10.1006/jmbi.1994.1633 notes: '' qc: n_common_residues: 271 n_common_core_lt3A: 154 n_switch_region_ge3A: 117 core_fraction: 0.568 - case_id: SFB_AL_SRC_2SRCA_1Y57A pattern: allosteric_ligand_induced query_uniprot: P12931 query_pdb: 2SRC query_chain: A query_resi_range: 84..533 query_length: 449 state_a_pdb: 2SRC state_a_chain: A state_b_pdb: 1Y57 state_b_chain: A target_state: B expected_pattern_signature: Src kinase autoinhibited (closed) <-> active (open) C-helix literature_ref: Cowan-Jacob 2005 Structure source: https://doi.org/10.1016/j.str.2005.04.013 notes: '' qc: n_common_residues: 449 n_common_core_lt3A: 12 n_switch_region_ge3A: 437 core_fraction: 0.027 - case_id: SFB_ID_ASYN_1XQ8A_1XQ8A pattern: idp_idr_disorder_to_order query_uniprot: P37840 query_pdb: 1XQ8 query_chain: A query_resi_range: 1..140 query_length: 140 state_a_pdb: 1XQ8 state_a_chain: A state_b_pdb: 1XQ8 state_b_chain: A target_state: A expected_pattern_signature: Alpha-synuclein disordered <-> lipid-bound helical conformation literature_ref: Ulmer 2005 JBC source: https://doi.org/10.1074/jbc.M411805200 notes: '' qc: n_common_residues: 140 n_common_core_lt3A: 140 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_BAD_1G5JB_1G5JB pattern: idp_idr_disorder_to_order query_uniprot: Q92934 query_pdb: 1G5J query_chain: B query_resi_range: 301..325 query_length: 25 state_a_pdb: 1G5J state_a_chain: B state_b_pdb: 1G5J state_b_chain: B target_state: A expected_pattern_signature: BAD BH3 IDR disorder-to-order on Bcl-xL binding literature_ref: Petros 2000 PNAS source: https://doi.org/10.1073/pnas.97.7.3012 notes: '' qc: n_common_residues: 25 n_common_core_lt3A: 25 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_BID_1DDBA_1DDBA pattern: idp_idr_disorder_to_order query_uniprot: P55957 query_pdb: 1DDB query_chain: A query_resi_range: 1..195 query_length: 195 state_a_pdb: 1DDB state_a_chain: A state_b_pdb: 1DDB state_b_chain: A target_state: A expected_pattern_signature: Bid alpha-helical bundle; BH3 region disordered-to-ordered upon Bcl-xL binding literature_ref: Chou 1999 Cell source: https://doi.org/10.1016/S0092-8674(00)80572-3 notes: '' qc: n_common_residues: 195 n_common_core_lt3A: 195 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_CJUN_1JNMB_1JNMB pattern: idp_idr_disorder_to_order query_uniprot: P05412 query_pdb: 1JNM query_chain: B query_resi_range: 254..310 query_length: 57 state_a_pdb: 1JNM state_a_chain: B state_b_pdb: 1JNM state_b_chain: B target_state: A expected_pattern_signature: c-Jun bZIP disorder-to-order coiled coil upon DNA binding/dimerization literature_ref: Glover 1995 Nature source: https://doi.org/10.1038/373257a0 notes: '' qc: n_common_residues: 57 n_common_core_lt3A: 57 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_CREB_1KDXB_1KDXB pattern: idp_idr_disorder_to_order query_uniprot: P16220 query_pdb: 1KDX query_chain: B query_resi_range: 119..146 query_length: 27 state_a_pdb: 1KDX state_a_chain: B state_b_pdb: 1KDX state_b_chain: B target_state: A expected_pattern_signature: CREB pKID alpha-helical disorder-to-order on KIX of CBP literature_ref: Radhakrishnan 1997 Cell source: https://doi.org/10.1016/S0092-8674(00)80463-8 notes: '' qc: n_common_residues: 27 n_common_core_lt3A: 27 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_EIF4E_1WKWB_1WKWB pattern: idp_idr_disorder_to_order query_uniprot: Q13541 query_pdb: 1WKW query_chain: B query_resi_range: 47..66 query_length: 20 state_a_pdb: 1WKW state_a_chain: B state_b_pdb: 1WKW state_b_chain: B target_state: A expected_pattern_signature: 4E-BP1 IDR ordered alpha-helix when bound eIF4E literature_ref: Marcotrigiano 1999 Mol Cell source: https://doi.org/10.1016/S1097-2765(00)80194-6 notes: '' qc: n_common_residues: 20 n_common_core_lt3A: 20 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_HIF1A_1L8CB_1L8CB pattern: idp_idr_disorder_to_order query_uniprot: Q16665 query_pdb: 1L8C query_chain: B query_resi_range: 99..149 query_length: 51 state_a_pdb: 1L8C state_a_chain: B state_b_pdb: 1L8C state_b_chain: B target_state: A expected_pattern_signature: HIF-1alpha CTAD disorder-to-order helix on CBP TAZ1 binding literature_ref: Dames 2002 PNAS source: https://doi.org/10.1073/pnas.082121399 notes: '' qc: n_common_residues: 51 n_common_core_lt3A: 51 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_HISTH1_1GHCA_1GHCA pattern: idp_idr_disorder_to_order query_uniprot: P10412 query_pdb: 1GHC query_chain: A query_resi_range: 1..75 query_length: 75 state_a_pdb: 1GHC state_a_chain: A state_b_pdb: 1GHC state_b_chain: A target_state: A expected_pattern_signature: Histone H1 globular domain ordered; long IDRs flank literature_ref: Ramakrishnan 1993 Nature source: https://doi.org/10.1038/362219a0 notes: '' qc: n_common_residues: 75 n_common_core_lt3A: 75 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_HMGB1_1AABA_1AABA pattern: idp_idr_disorder_to_order query_uniprot: P09429 query_pdb: 1AAB query_chain: A query_resi_range: 1..83 query_length: 83 state_a_pdb: 1AAB state_a_chain: A state_b_pdb: 1AAB state_b_chain: A target_state: A expected_pattern_signature: 'HMGB1 box A: ordered when bound DNA; flexible apo termini' literature_ref: Hardman 1995 Biochemistry source: https://doi.org/10.1021/bi00050a012 notes: '' qc: n_common_residues: 83 n_common_core_lt3A: 83 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_NCOA1_1KBHB_1KBHB pattern: idp_idr_disorder_to_order query_uniprot: Q15788 query_pdb: 1KBH query_chain: B query_resi_range: 48..106 query_length: 59 state_a_pdb: 1KBH state_a_chain: B state_b_pdb: 1KBH state_b_chain: B target_state: A expected_pattern_signature: NCOA1 NRID disorder-to-order helical when bound to CBP literature_ref: Demarest 2002 Nature source: https://doi.org/10.1038/nature724 notes: '' qc: n_common_residues: 59 n_common_core_lt3A: 59 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_NUMB_1WJ1A_1WJ1A pattern: idp_idr_disorder_to_order query_uniprot: P49757 query_pdb: 1WJ1 query_chain: A query_resi_range: 1..156 query_length: 156 state_a_pdb: 1WJ1 state_a_chain: A state_b_pdb: 1WJ1 state_b_chain: A target_state: A expected_pattern_signature: Numb PTB IDR disorder-to-order on peptide binding literature_ref: Li 1998 EMBO J source: https://doi.org/10.1093/emboj/17.24.7320 notes: '' qc: n_common_residues: 156 n_common_core_lt3A: 156 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_P27_1JSUC_1JSUC pattern: idp_idr_disorder_to_order query_uniprot: P46527 query_pdb: 1JSU query_chain: C query_resi_range: 25..93 query_length: 69 state_a_pdb: 1JSU state_a_chain: C state_b_pdb: 1JSU state_b_chain: C target_state: A expected_pattern_signature: p27 KID region disorder-to-order upon Cdk2/cyclinA binding literature_ref: Russo 1996 Nature source: https://doi.org/10.1038/382325a0 notes: p27 alone is disordered; bound to Cdk2/CycA forms extended ordered conformation qc: n_common_residues: 69 n_common_core_lt3A: 69 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_P53TAD_2K8FA_2K8FA pattern: idp_idr_disorder_to_order query_uniprot: P04637 query_pdb: 2K8F query_chain: A query_resi_range: 1..90 query_length: 90 state_a_pdb: 2K8F state_a_chain: A state_b_pdb: 2K8F state_b_chain: A target_state: A expected_pattern_signature: p53 TAD2 disorder-to-order helical conformation literature_ref: Lee 2010 PNAS source: https://doi.org/10.1073/pnas.0915169107 notes: '' qc: n_common_residues: 90 n_common_core_lt3A: 90 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_PKID_1KDXB_1KDXB pattern: idp_idr_disorder_to_order query_uniprot: Q01147 query_pdb: 1KDX query_chain: B query_resi_range: 119..146 query_length: 27 state_a_pdb: 1KDX state_a_chain: B state_b_pdb: 1KDX state_b_chain: B target_state: A expected_pattern_signature: pKID disorder-to-order upon KIX binding (CREB-CBP) literature_ref: Radhakrishnan 1997 Cell source: https://doi.org/10.1016/S0092-8674(00)80463-8 notes: '' qc: n_common_residues: 27 n_common_core_lt3A: 27 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_ID_PUMA_2M04B_2M04B pattern: idp_idr_disorder_to_order query_uniprot: Q9BXH1 query_pdb: 2M04 query_chain: B query_resi_range: 68..92 query_length: 25 state_a_pdb: 2M04 state_a_chain: B state_b_pdb: 2M04 state_b_chain: B target_state: A expected_pattern_signature: PUMA BH3-only IDR forms ordered helix bound to Bcl-xL literature_ref: Rogers 2014 Structure source: https://doi.org/10.1016/j.str.2014.02.005 notes: '' qc: n_common_residues: 25 n_common_core_lt3A: 25 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_OL_BARNASE_1A2PA_1YVSA pattern: oligomer_domain_swap query_uniprot: P00648 query_pdb: 1A2P query_chain: A query_resi_range: 3..110 query_length: 108 state_a_pdb: 1A2P state_a_chain: A state_b_pdb: 1YVS state_b_chain: A target_state: B expected_pattern_signature: Barnase monomer <-> engineered domain-swapped dimer literature_ref: Zegers 1999 PNAS source: https://doi.org/10.1073/pnas.96.3.818 notes: '' qc: n_common_residues: 108 n_common_core_lt3A: 70 n_switch_region_ge3A: 38 core_fraction: 0.648 - case_id: SFB_OL_BCLXL_1LXLA_1R2DA pattern: oligomer_domain_swap query_uniprot: Q07817 query_pdb: 1LXL query_chain: A query_resi_range: -3..217 query_length: 221 state_a_pdb: 1LXL state_a_chain: A state_b_pdb: 1R2D state_b_chain: A target_state: B expected_pattern_signature: Bcl-xL monomer <-> domain-swapped dimer (apoptosis regulator) literature_ref: Muchmore 1996 Nature source: https://doi.org/10.1038/381335a0 notes: '' qc: n_common_residues: 142 n_common_core_lt3A: 125 n_switch_region_ge3A: 17 core_fraction: 0.88 - case_id: SFB_OL_CALBD9K_4ICBA_1HT9A pattern: oligomer_domain_swap query_uniprot: P05937 query_pdb: 4ICB query_chain: A query_resi_range: 0..75 query_length: 76 state_a_pdb: 4ICB state_a_chain: A state_b_pdb: 1HT9 state_b_chain: A target_state: B expected_pattern_signature: Calbindin D9k monomer <-> domain-swapped dimer (EF-hand) literature_ref: Hakansson 2001 Protein Sci source: https://doi.org/10.1110/ps.06301 notes: '' qc: n_common_residues: 76 n_common_core_lt3A: 44 n_switch_region_ge3A: 32 core_fraction: 0.579 - case_id: SFB_OL_CCL2_1DOKA_1DOMA pattern: oligomer_domain_swap query_uniprot: P13500 query_pdb: 1DOK query_chain: A query_resi_range: 0..71 query_length: 72 state_a_pdb: 1DOK state_a_chain: A state_b_pdb: 1DOM state_b_chain: A target_state: B expected_pattern_signature: CCL2/MCP-1 monomer (1DOK) <-> dimer (1DOM) chemokine assembly literature_ref: Lubkowski 1997 Nat Struct Biol source: https://doi.org/10.1038/nsb0197-64 notes: '' qc: n_common_residues: 71 n_common_core_lt3A: 66 n_switch_region_ge3A: 5 core_fraction: 0.93 - case_id: SFB_OL_CVN_1IIYA_3EZMA pattern: oligomer_domain_swap query_uniprot: P81180 query_pdb: 1IIY query_chain: A query_resi_range: 1..101 query_length: 101 state_a_pdb: 1IIY state_a_chain: A state_b_pdb: 3EZM state_b_chain: A target_state: B expected_pattern_signature: Cyanovirin-N monomer <-> domain-swapped dimer (HIV-binding lectin) literature_ref: Yang 1999 JMB source: https://doi.org/10.1006/jmbi.1999.3293 notes: '' qc: n_common_residues: 101 n_common_core_lt3A: 2 n_switch_region_ge3A: 99 core_fraction: 0.02 - case_id: SFB_OL_CYSTC_3GAXA_1TIJA pattern: oligomer_domain_swap query_uniprot: P01034 query_pdb: 3GAX query_chain: A query_resi_range: 12..120 query_length: 107 state_a_pdb: 3GAX state_a_chain: A state_b_pdb: 1TIJ state_b_chain: A target_state: B expected_pattern_signature: Cystatin C monomer (3GAX) <-> domain-swapped dimer (1TIJ) literature_ref: Janowski 2001 Nat Struct Biol source: https://doi.org/10.1038/89638 notes: '' qc: n_common_residues: 107 n_common_core_lt3A: 56 n_switch_region_ge3A: 51 core_fraction: 0.523 - case_id: SFB_OL_DTOX_1F0LA_1DDTA pattern: oligomer_domain_swap query_uniprot: P00588 query_pdb: 1F0L query_chain: A query_resi_range: 1..535 query_length: 520 state_a_pdb: 1F0L state_a_chain: A state_b_pdb: 1DDT state_b_chain: A target_state: B expected_pattern_signature: Diphtheria toxin monomer <-> domain-swapped dimer literature_ref: Bennett 1994 Protein Sci source: https://doi.org/10.1002/pro.5560030917 notes: '' qc: n_common_residues: 520 n_common_core_lt3A: 363 n_switch_region_ge3A: 157 core_fraction: 0.698 - case_id: SFB_OL_ENGRAILED_1ENHA_2JWTA pattern: oligomer_domain_swap query_uniprot: P02836 query_pdb: 1ENH query_chain: A query_resi_range: 3..56 query_length: 54 state_a_pdb: 1ENH state_a_chain: A state_b_pdb: 2JWT state_b_chain: A target_state: B expected_pattern_signature: Engrailed homeodomain monomer <-> swapped dimer literature_ref: Clarke 1994 Structure source: https://doi.org/10.1016/S0969-2126(00)00006-7 notes: '' qc: n_common_residues: 54 n_common_core_lt3A: 51 n_switch_region_ge3A: 3 core_fraction: 0.944 - case_id: SFB_OL_ETA_1AOHA_1AOHB pattern: oligomer_domain_swap query_uniprot: P00552 query_pdb: 1AOH query_chain: A query_resi_range: 5..147 query_length: 143 state_a_pdb: 1AOH state_a_chain: A state_b_pdb: 1AOH state_b_chain: B target_state: B expected_pattern_signature: Eta toxin monomer <-> swapped oligomeric form literature_ref: Bennett 1995 PNAS source: https://doi.org/10.1073/pnas.91.8.3127 notes: '' qc: n_common_residues: 143 n_common_core_lt3A: 143 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_OL_GB1SW_2QMTA_1Q9VA pattern: oligomer_domain_swap query_uniprot: P19909 query_pdb: 2QMT query_chain: A query_resi_range: 1..56 query_length: 56 state_a_pdb: 2QMT state_a_chain: A state_b_pdb: 1Q9V state_b_chain: A target_state: B expected_pattern_signature: Protein GB1 monomer <-> domain-swapped tetramer (engineered) literature_ref: Byeon 2003 JMB source: https://doi.org/10.1016/j.jmb.2003.08.005 notes: '' qc: n_common_residues: 56 n_common_core_lt3A: 0 n_switch_region_ge3A: 56 core_fraction: 0.0 - case_id: SFB_OL_HIVPR_1HHPA_3HVPA pattern: oligomer_domain_swap query_uniprot: P03366 query_pdb: 1HHP query_chain: A query_resi_range: 1..99 query_length: 99 state_a_pdb: 1HHP state_a_chain: A state_b_pdb: 3HVP state_b_chain: A target_state: B expected_pattern_signature: HIV-1 protease dimer interface conformation (1HHP) <-> alternate (3HVP) literature_ref: Spinelli 1991 Biochimie source: https://doi.org/10.1016/0300-9084(91)90168-Z notes: '' qc: n_common_residues: 97 n_common_core_lt3A: 97 n_switch_region_ge3A: 0 core_fraction: 1.0 - case_id: SFB_OL_IL5_1HULA_1HULB pattern: oligomer_domain_swap query_uniprot: P05113 query_pdb: 1HUL query_chain: A query_resi_range: 5..112 query_length: 108 state_a_pdb: 1HUL state_a_chain: A state_b_pdb: 1HUL state_b_chain: B target_state: B expected_pattern_signature: Interleukin-5 obligate domain-swapped homodimer literature_ref: Milburn 1993 Nature source: https://doi.org/10.1038/363172a0 notes: '' qc: n_common_residues: 108 n_common_core_lt3A: 106 n_switch_region_ge3A: 2 core_fraction: 0.981 - case_id: SFB_OL_RNASA_7RSAA_1A2WA pattern: oligomer_domain_swap query_uniprot: P61823 query_pdb: 7RSA query_chain: A query_resi_range: 1..124 query_length: 124 state_a_pdb: 7RSA state_a_chain: A state_b_pdb: 1A2W state_b_chain: A target_state: B expected_pattern_signature: Bovine RNase A monomer (7RSA) <-> C-terminal domain-swapped dimer (1A2W) literature_ref: Liu 1998 Protein Sci source: https://doi.org/10.1002/pro.5560070806 notes: '' qc: n_common_residues: 124 n_common_core_lt3A: 104 n_switch_region_ge3A: 20 core_fraction: 0.839 - case_id: SFB_OL_STEFINB_1STFI_2OCTA pattern: oligomer_domain_swap query_uniprot: P04080 query_pdb: 1STF query_chain: I query_resi_range: 6..125 query_length: 98 state_a_pdb: 1STF state_a_chain: I state_b_pdb: 2OCT state_b_chain: A target_state: B expected_pattern_signature: Stefin B monomer <-> domain-swapped dimer (cystatin family) literature_ref: Janowski 2001 Nat Struct Biol source: https://doi.org/10.1038/89638 notes: '' qc: n_common_residues: 68 n_common_core_lt3A: 0 n_switch_region_ge3A: 68 core_fraction: 0.0 - case_id: SFB_OL_SUC1_1PUCA_1SCEA pattern: oligomer_domain_swap query_uniprot: P14635 query_pdb: 1PUC query_chain: A query_resi_range: 2..102 query_length: 101 state_a_pdb: 1PUC state_a_chain: A state_b_pdb: 1SCE state_b_chain: A target_state: B expected_pattern_signature: p13suc1 closed monomer <-> beta-strand-swapped dimer literature_ref: Bourne 1996 Cell source: https://doi.org/10.1016/S0092-8674(00)81092-2 notes: '' qc: n_common_residues: 97 n_common_core_lt3A: 88 n_switch_region_ge3A: 9 core_fraction: 0.907