# PANSEGX post-processing — false-positive reduction

> **Optional** step applied downstream of ONNX/TensorRT inference, on the full
> reassembled probability volume. It changes neither the weights nor the graph:
> it cleans up the output. See [`postprocess.py`](postprocess.py).

## Why

The original checkpoint ships **no** post-processing (`postprocessing.pkl` was
never computed), and the reference inference command runs without TTA
(`--disable_tta`). Its dominant failure mode is documented: **scattered
false positives** rather than missed lesions.

| Pattern (35 cases with DSC < 0.5) | Frequency |
|---|---|
| FRAGMENTED (≥3× more components than GT) | 91 % |
| OVER_SEG (predicted volume >3× GT) | 74 % |
| LOCATION_OFFSET (centroid >30 mm) | 100 % |
| NO_OVERLAP (precision & recall <0.1) | 14 % |

Removing the "fog" of spurious components mechanically fixes fragmentation,
over-segmentation and centroid drift. NO_OVERLAP (14 %) stems from partial
labels at training time and is **out of reach** for any post-processing.

## Core idea: connected-component hysteresis

A plain `argmax` (prob ≥ 0.5) keeps all of the fog, which precisely crossed 0.5.
Raising a single global threshold erodes the boundary of true lesions and hurts
**NSD**. The right answer is hysteresis:

- **`t_low` (low)** defines the candidate extent → preserves boundaries (good for NSD);
- **`t_high` (high)** defines confident "seed" cores;
- a component of the low mask is kept only if it contains **at least one seed**.

True lesions almost always have a highly confident core; the false-positive fog
does not. Two physical guards are added: **minimum volume in mm³** (via the
spacing) and **minimum core confidence**.

> ⚠️ **No "keep the largest component".** This is pan-cancer segmentation:
> multiple metastatic lesions are legitimate. The module is **multi-lesion by
> default** (`keep_top_k = None`).

## Parameters

| Parameter | Default | Role |
|---|---|---|
| `t_low` | 0.50 | low threshold — candidate extent (preserves boundaries) |
| `t_high` | 0.90 | high threshold — confident seed core (hysteresis) |
| `min_volume_mm3` | 50.0 | minimum component volume (physical scale) |
| `min_core_prob` | 0.90 | minimum peak probability required within a component |
| `min_mean_prob` | 0.0 | minimum mean probability (0 = disabled) |
| `connectivity` | 26 | 3D neighbourhood (6 / 18 / 26) |
| `fill_holes` | True | fills internal holes (DSC gain, boundary-neutral) |
| `keep_top_k` | None | keep only the *k* largest (None = all) |
| `drop_border_components` | False | drop components touching the FOV border |

> **Defaults are starting points, not optima.** Lock them in via calibration
> (below) so recall is not degraded.

## Usage

### Command line (NIfTI)

```bash
python postprocess.py \
  --input  prob.nii.gz \        # tumor probability map (Z,Y,X) OR logits
  --output mask.nii.gz \
  --t-high 0.90 --min-volume-mm3 50 \
  --report                      # per-component diagnostics (optional)
```

Spacing is read from the NIfTI header, so volumes are computed in mm³.

### Python API

```python
from postprocess import postprocess, PostProcConfig

# ONNX logits of shape (2, Z, Y, X) OR a probability map (Z, Y, X)
mask = postprocess(
    logits_or_prob,
    spacing_zyx=(1.0, 0.787, 0.787),   # (z, y, x) in mm
    config=PostProcConfig(t_high=0.90, min_volume_mm3=50.0),
)

# diagnostics
mask, report = postprocess(logits_or_prob, spacing, return_report=True)
# report["components"] -> [{volume_mm3, peak_prob, mean_prob, kept, reason}, ...]
```

The module accepts either a probability map `(Z,Y,X)` or 2-class logits
`(2,Z,Y,X)` (2-class softmax = numerically stable sigmoid).

## Calibration on the 50 validation-public cases

This is what `nnUNetv2_determine_postprocessing` would have done — to be done
here manually, since the baseline never produced it:

```python
from postprocess import calibrate

best_cfg, table = calibrate(
    prob_maps, gts, spacings,   # aligned lists (probability maps / GT masks / spacings)
    metric="nsd",               # "dsc" | "nsd" | "mean"
)
print(best_cfg)      # optimal config
print(table[:5])     # best grid combinations
```

It sweeps `t_high`, `min_volume_mm3`, `min_core_prob` and maximizes the mean
metric over the cohort. Pick the point that maximizes DSC/NSD **without
collapsing recall**.

## Demonstration (synthetic volume: 1 lesion + 40 false positives)

```
BASELINE argmax 0.5 : CC = 41   DSC = 0.379   NSD@2mm = 0.375
POST-PROCESS        : CC =  1   DSC = 0.444   NSD@2mm = 0.554
```

## Caveats

1. **Defaults must be calibrated** (see above) before reporting any numbers.
2. The bundled `surface_dice` is a **reference implementation** (boundaries via
   erosion, distances via anisotropic EDT): **verify it against the official
   FLARE scorer** before publishing metrics.
3. Post-processing **recovers no missed lesion** (NO_OVERLAP) — only retraining
   would address the partial-label issue.

## Dependencies

`numpy`, `scipy` (required); `SimpleITK` (NIfTI I/O for the CLI); `cc3d` (speeds up
labelling, automatic fallback to `scipy.ndimage` otherwise).