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  ![GALAX Overall Architecture](./Figure3.png)
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- **GALAX** is a graph-augmented language model that integrates:
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- - **LLaMA3-8B-Instruct** as the language backbone (Target-QA tuned).
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- - **Graph Attention Network (GAT)** trained on BioMedGraphica (multi-omics + knowledge graph).
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- - **Reinforcement-guided subgraph generator** for interpretable target prioritization.
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- The model unifies **multi-omics features** with **protein–protein interactions** and **disease–target associations**, enabling **explainable CRISPR target prioritization** across cancer cell lines.
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  ![GALAX Overall Architecture](./Figure3.png)
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+ **GALAX** is a graph-augmented language model designed for explainable target prioritization in precision medicine. It combines three key components:
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+ - **LLaMA3-8B-Instruct** as the language backbone, further adapted with the BioMedGraphica corpus and fine-tuned on Target-QA.
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+ - **Graph Attention Network (GAT)** pretrained on integrated multi-omics data and BioMedGraphica knowledge graphs.
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+ - **A reinforcement-guided subgraph generator** that enables interpretable reasoning by constructing biologically meaningful subgraphs from multi-omics and knowledge graph signals.
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+ By jointly leveraging **multi-omics features**, **protein–protein interactions**, and **disease–target associations**, GALAX provides an interpretable framework for **CRISPR target prioritization** across diverse cancer cell lines. To support benchmarking and reproducibility, we also introduce the **[Target-QA dataset](https://huggingface.co/datasets/FuhaiLiAiLab/Target-QA)**.
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