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- ---
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- license: openrail
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- ---
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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+ ---
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+ license: openrail
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+
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+ language:
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+ - en
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+ tags:
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+ - RNA
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+ - biology
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+ - generative
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+ - foundation-model
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+ - language-model
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+ - sequence-design
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+ pipeline_tag: text-generation
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+ ---
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+
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+ # EVA: Evolutionary Versatile Architect
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+
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+ EVA is a generative foundation model for universal RNA modeling and design,
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+ trained on **RNAVerse v1** — a curated atlas of **114 million full-length RNA
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+ sequences** spanning all domains of life.
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+
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+ ## Model Description
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+
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+ | Property | Details |
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+ |----------|---------|
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+ | Architecture | Decoder-only Transformer + Mixture-of-Experts (MoE) |
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+ | Parameters | 1.4B (also available: 21M, 167M, 470M) |
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+ | Context Window | 8,192 tokens |
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+ | Training Data | 114M full-length RNA sequences (RNAVerse v1) |
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+ | Training Objectives | Causal LM (CLM) + Generalized LM (GLM), 2:1 ratio |
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+ | Conditioning | RNA type tags + taxonomic lineage tags |
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+
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+ ## Capabilities
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+
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+ **🔬 Zero-shot Fitness Prediction**
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+ Predicts mutational effects across RNA, DNA gene regions, and proteins
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+ using evolutionary likelihood — no fine-tuning required.
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+
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+ **🧬 Controllable RNA Generation**
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+ Supports de novo generation and targeted region redesign across 11 RNA
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+ classes: mRNA, lncRNA, circRNA, tRNA, rRNA, miRNA, piRNA, sRNA, snRNA,
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+ snoRNA, and viral RNA.
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+
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+ **💉 Vaccine Design**
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+ Species-aware codon optimization for mRNA and circRNA vaccines;
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+ de novo IRES redesign via GLM masked infilling.
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+
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+ **🦠 Functional RNA Engineering**
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+ Fine-tuning-ready for tRNA design, RNA aptamer optimization, and
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+ CRISPR guide RNA (omegaRNA) generation.
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+
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+ ## Usage
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+
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+ # Coming soon