Update model card: full Patterns author list, ELF-NET application note
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README.md
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license: mit
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tags:
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pipeline_tag: text-classification
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---
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**Type:** Causal language model for protein sequence classification
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**Base:** nanoGPT (Andrej Karpathy)
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**Task:** Binary classification of microalgal vs. contaminant protein sequences
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**Mode:** TI-inclusive (full-length sequences)
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- **Algal sources:** 166 microalgal genomes across 10 phyla
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- **Contaminant sources:** Bacterial, archaeal, and fungal sequences from NCBI nr
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| Metric | Score |
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| Recall | >99% |
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| Speed vs
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## Usage
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## Citation
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## Contact
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Kourosh Salehi-Ashtiani
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ksa3@nyu.edu
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---
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license: mit
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tags:
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- biology
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- protein-classification
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- microalgae
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- genomics
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- nanoGPT
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- metagenomics
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- tara-oceans
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pipeline_tag: text-classification
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# algaGPT
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Causal language model for binary classification of microalgal vs. contaminant protein sequences.
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## Model Description
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- **Architecture:** nanoGPT (Andrej Karpathy)
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- **Task:** Binary classification of microalgal protein sequences via next-token prediction
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- **Mode:** TI-inclusive (full-length sequences)
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- **Training data:** ~58.6M protein sequences (1:1 algal:contaminant ratio)
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- **Algal sources:** 166 microalgal genomes across 10 phyla
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- **Contaminant sources:** Bacterial, archaeal, and fungal sequences from NCBI nr
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| Metric | Score |
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| Recall | >99% |
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| Speed vs. BLASTp | ~10,701x faster |
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## Usage
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**Input:** Protein sequence (amino acid string)
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**Output:** Classification tag (algal/contaminant) via next-token prediction
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## Applications
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algaGPT was used as the primary proteome extraction tool in the ELF-NET study (Nelson et al., forthcoming), where it purified algal protein sequences from 2,044 TARA Oceans metagenome assemblies, yielding 221.9 million sequences for downstream domain-environment coupling analysis.
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## Authors
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David R. Nelson, Ashish Kumar Jaiswal, Noha Samir Ismail, Alexandra Mystikou, Kourosh Salehi-Ashtiani
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Green Genomics Lab, New York University Abu Dhabi
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## Citation
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```bibtex
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@article{la4sr2025,
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title={Pan-microalgal dark proteome mapping via interpretable deep learning and synthetic chimeras},
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author={Nelson, David R. and Jaiswal, Ashish Kumar and Ismail, Noha Samir and Mystikou, Alexandra and Salehi-Ashtiani, Kourosh},
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journal={Patterns},
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volume={6},
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pages={101373},
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year={2025},
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publisher={Cell Press},
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doi={10.1016/j.patter.2025.101373}
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}
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```
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## Contact
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Kourosh Salehi-Ashtiani — ksa3@nyu.edu
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