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GPT-2 finetuned model for **classifying DNA sequences** into **introns** and **exons**, trained on a large cross-species GenBank dataset.
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- Base model: GPT-2
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- Approach: Full-sequence classification
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- Framework: PyTorch + Hugging Face Transformers
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## Usage
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```python
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The model should predict the next token as the class label: `[EXON]` or `[INTRON]`.
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The model was trained on a processed version of GenBank sequences spanning multiple species.
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- **Short Paper (International)**
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Presented at the _IEEE International Conference on Bioinformatics and BioEngineering (BIBE 2025)_, held in Athens, Greece.
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[https://doi.org/10.1109/BIBE66822.2025.00113](https://doi.org/10.1109/BIBE66822.2025.00113)
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## Training
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- Trained on an architecture with 8x H100 GPUs.
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## GitHub Repository
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The full code for **data processing, model training, and inference** is available on GitHub:
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GPT-2 finetuned model for **classifying DNA sequences** into **introns** and **exons**, trained on a large cross-species GenBank dataset.
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## Model Architecture
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- Base model: GPT-2
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- Approach: Full-sequence classification
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- Framework: PyTorch + Hugging Face Transformers
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---
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## Usage
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```python
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The model should predict the next token as the class label: `[EXON]` or `[INTRON]`.
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---
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## Dataset
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The model was trained on a processed version of GenBank sequences spanning multiple species.
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- **Short Paper (International)**
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Presented at the _IEEE International Conference on Bioinformatics and BioEngineering (BIBE 2025)_, held in Athens, Greece.
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[https://doi.org/10.1109/BIBE66822.2025.00113](https://doi.org/10.1109/BIBE66822.2025.00113)
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## Training
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- Trained on an architecture with 8x H100 GPUs.
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---
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## Metrics
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**Average accuracy:** **0.9985**
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| Class | Precision | Recall | F1-Score |
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|--------|-----------|--------|----------|
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| **Intron** | 0.9977 | 0.9973 | 0.9975 |
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| **Exon** | 0.9988 | 0.9990 | 0.9989 |
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---
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### **Notes**
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- Metrics were computed on the full test set.
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- Classes are approximately balanced, allowing direct interpretation of the scores.
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- The model operates on raw nucleotide sequences without additional biological features.
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## GitHub Repository
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The full code for **data processing, model training, and inference** is available on GitHub:
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