{ "primary_method": "highest-specificity threshold with sensitivity >= 0.95 on validation (calibrated probabilities)", "locked_threshold": 0.7113139033317566, "valid_sensitivity_at_threshold": 0.952, "valid_specificity_at_threshold": 0.896, "target_sensitivity": 0.95, "target_achievable": true, "secondary_youden": { "threshold": 0.7113139033317566, "sensitivity": 0.952, "specificity": 0.896 }, "probabilities_used": "calibrated" }