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README.md
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# ProGemma
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This model is
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### Training hyperparameters
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The following hyperparameters were used during training:
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- learning_rate: 0.001
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- train_batch_size: 1
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- eval_batch_size: 8
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- seed: 42
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- optimizer: Adam with betas=(0.9,0.999) and epsilon=1e-08
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- lr_scheduler_type: linear
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- lr_scheduler_warmup_ratio: 0.4
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- training_steps: 7000
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### Training results
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### Framework versions
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# ProGemma
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This is a custom configuration of Google's Gemma 2 model that is being pre-trained on amino acid sequences of lengths 0 to 512. Updates are made regularly as the model hits new checkpoints. As of 08.10.2024, the model has been trained on about 40% of the dataset.
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The model generates amino acids on a letter-by-letter basis.
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Current training loss is about 2.7. Preliminary evaluation of generated sequences on AlphaFold 3 shows pTM scores of ~0.4 and average pLLDT scores ~60. After training is complete, a proper evaluation will be done to see whether sequences result in proteins with a low free energy. Current perplexity scores are on par with NVIDIA's ProtGPT2.
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The purpose of this model was to see whether I could develop an alternative to NVIDIA's ProtGPT2. ProGemma also serves as a stepping stone to a new model that will also utilize control tags to generate proteins based on function.
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To use this mode for yourself using the pipeline within the Transformers package, please see the code below:
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from transformers import pipeline, AutoTokenizer, AutoModelForCausalLM
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model = AutoModelForCausalLM.from_pretrained("JuIm/ProGemma") tokenizer = AutoTokenizer.from_pretrained("JuIm/Amino-Acid-Sequence-Tokenizer")
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progemma = pipeline("text-generation", model=model, tokenizer=tokenizer)
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sequence = progemma("\<bos>", top_k=950, max_length=100, num_return_sequences=1, do_sample=True, repetition_penalty=1.2, eos_token_id=21, pad_token_id=22, bos_token_id=20)
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print(sequence)
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### Framework versions
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