Update README.md
Browse files
README.md
CHANGED
|
@@ -5,23 +5,35 @@ pipeline_tag: image-segmentation
|
|
| 5 |
|
| 6 |
<img src="imgs/nnInteractive_header_white.png">
|
| 7 |
|
| 8 |
-
#
|
| 9 |
|
| 10 |
This repository provides the official checkpoints for `nnInteractive`, a state-of-the-art framework for 3D promptable segmentation.
|
| 11 |
-
|
| 12 |
The backend is designed for seamless integration into Python-based workflows—ideal for researchers, developers, and power users working directly with code.
|
| 13 |
`nnInteractive` is also available through graphical viewers (GUI) for those who prefer a visual workflow. The napari and MITK integrations are developed and maintained by our team. Thanks to the community for contributing the 3D Slicer extension!
|
| 14 |
|
| 15 |
|
|
|
|
| 16 |
<div align="center">
|
| 17 |
|
| 18 |
-
| **<div align="center">[napari plugin](https://github.com/MIC-DKFZ/napari-nninteractive)</div>** | **<div align="center">[MITK integration](https://www.mitk.org/wiki/MITK-nnInteractive)</div>** | **<div align="center">[3D Slicer extension](https://github.com/coendevente/SlicerNNInteractive)</div>** |
|
| 19 |
-
|-------------------|----------------------|-------------------------|
|
| 20 |
-
| [<img src="imgs/Logos/napari.jpg" width="200">](https://github.com/MIC-DKFZ/napari-nninteractive) | [<img src="imgs/Logos/mitk.jpg" width="200">](https://www.mitk.org/wiki/MITK-nnInteractive) | [<img src="imgs/Logos/3DSlicer.png" width="200">](https://github.com/coendevente/SlicerNNInteractive) |
|
| 21 |
|
| 22 |
</div>
|
| 23 |
|
| 24 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 25 |
## What is nnInteractive?
|
| 26 |
|
| 27 |
> Isensee, F.\*, Rokuss, M.\*, Krämer, L.\*, Dinkelacker, S., Ravindran, A., Stritzke, F., Hamm, B., Wald, T., Langenberg, M., Ulrich, C., Deissler, J., Floca, R., & Maier-Hein, K. (2025). nnInteractive: Redefining 3D Promptable Segmentation. https://arxiv.org/abs/2503.08373 \
|
|
@@ -49,6 +61,172 @@ standard for AI-driven interactive 3D segmentation.
|
|
| 49 |
<img src="imgs/figure1_method.png" width="1200">
|
| 50 |
|
| 51 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 52 |
## Citation
|
| 53 |
When using nnInteractive, please cite the following paper:
|
| 54 |
|
|
@@ -59,7 +237,27 @@ Link: [](https
|
|
| 59 |
|
| 60 |
|
| 61 |
# License
|
| 62 |
-
Note that the [model checkpoint](https://huggingface.co/nnInteractive/nnInteractive) is `Creative Commons Attribution Non Commercial Share Alike 4.0`!
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 63 |
|
| 64 |
## Acknowledgments
|
| 65 |
|
|
|
|
| 5 |
|
| 6 |
<img src="imgs/nnInteractive_header_white.png">
|
| 7 |
|
| 8 |
+
# nnInteractive: Redefining 3D Promptable Segmentation
|
| 9 |
|
| 10 |
This repository provides the official checkpoints for `nnInteractive`, a state-of-the-art framework for 3D promptable segmentation.
|
| 11 |
+
Check out the corresponding [python backend](https://github.com/MIC-DKFZ/nnInteractive).
|
| 12 |
The backend is designed for seamless integration into Python-based workflows—ideal for researchers, developers, and power users working directly with code.
|
| 13 |
`nnInteractive` is also available through graphical viewers (GUI) for those who prefer a visual workflow. The napari and MITK integrations are developed and maintained by our team. Thanks to the community for contributing the 3D Slicer extension!
|
| 14 |
|
| 15 |
|
| 16 |
+
|
| 17 |
<div align="center">
|
| 18 |
|
| 19 |
+
| **<div align="center">[napari plugin](https://github.com/MIC-DKFZ/napari-nninteractive)</div>** | **<div align="center">[MITK integration](https://www.mitk.org/wiki/MITK-nnInteractive)</div>** | **<div align="center">[3D Slicer extension](https://github.com/coendevente/SlicerNNInteractive)</div>** | **<div align="center">[ITK-SNAP extension](https://itksnap-dls.readthedocs.io/en/latest/quick_start.html)</div>** |
|
| 20 |
+
|-------------------|----------------------|-------------------------|-------------------------|
|
| 21 |
+
| [<img src="imgs/Logos/napari.jpg" width="200">](https://github.com/MIC-DKFZ/napari-nninteractive) | [<img src="imgs/Logos/mitk.jpg" width="200">](https://www.mitk.org/wiki/MITK-nnInteractive) | [<img src="imgs/Logos/3DSlicer.png" width="200">](https://github.com/coendevente/SlicerNNInteractive) | [<img src="imgs/Logos/snaplogo_sq.png" width="200">](https://itksnap-dls.readthedocs.io/en/latest/quick_start.html) |
|
| 22 |
|
| 23 |
</div>
|
| 24 |
|
| 25 |
|
| 26 |
+
## 📰 News
|
| 27 |
+
|
| 28 |
+
- **07/2025**: 🧩 New ITK-SNAP extension released! Try nnInteractive directly in ITK-SNAP 👉 [Quick Start](https://itksnap-dls.readthedocs.io/en/latest/quick_start.html)
|
| 29 |
+
- **06/2025**: 🏆 We’re thrilled to announce that `nnInteractive` **won the 1st place** in the [CVPR 2025 Challenge on Interactive 3D Segmentation](https://www.codabench.org/competitions/5263/). Huge shoutout to the organizers and all contributors!
|
| 30 |
+
- **05/2025**: `nnInteractive` presents an **official baseline** at **CVPR 2025** in the _Foundation Models for Interactive 3D Biomedical Image Segmentation Challenge_ ([Codabench link](https://www.codabench.org/competitions/5263/)) → see [`nnInteractive/inference/cvpr2025_challenge_baseline`](nnInteractive/inference/cvpr2025_challenge_baseline)
|
| 31 |
+
- **04/2025**: 🎉 The **community contributed a 3D Slicer integration** – thank you! 👉 [SlicerNNInteractive](https://github.com/coendevente/SlicerNNInteractive)
|
| 32 |
+
- **03/2025**: 🚀 `nnInteractive` **launched** with native support for **napari** and **MITK**
|
| 33 |
+
|
| 34 |
+
---
|
| 35 |
+
|
| 36 |
+
|
| 37 |
## What is nnInteractive?
|
| 38 |
|
| 39 |
> Isensee, F.\*, Rokuss, M.\*, Krämer, L.\*, Dinkelacker, S., Ravindran, A., Stritzke, F., Hamm, B., Wald, T., Langenberg, M., Ulrich, C., Deissler, J., Floca, R., & Maier-Hein, K. (2025). nnInteractive: Redefining 3D Promptable Segmentation. https://arxiv.org/abs/2503.08373 \
|
|
|
|
| 61 |
<img src="imgs/figure1_method.png" width="1200">
|
| 62 |
|
| 63 |
|
| 64 |
+
## Installation
|
| 65 |
+
|
| 66 |
+
### Prerequisites
|
| 67 |
+
|
| 68 |
+
You need a Linux or Windows computer with a Nvidia GPU. 10GB of VRAM is recommended. Small objects should work with \<6GB.
|
| 69 |
+
|
| 70 |
+
##### 1. Create a virtual environment:
|
| 71 |
+
|
| 72 |
+
nnInteractive supports Python 3.10+ and works with Conda, pip, or any other virtual environment. Here’s an example using Conda:
|
| 73 |
+
|
| 74 |
+
```
|
| 75 |
+
conda create -n nnInteractive python=3.12
|
| 76 |
+
conda activate nnInteractive
|
| 77 |
+
```
|
| 78 |
+
|
| 79 |
+
##### 2. Install the correct PyTorch for your system
|
| 80 |
+
|
| 81 |
+
Go to the [PyTorch homepage](https://pytorch.org/get-started/locally/) and pick the right configuration.
|
| 82 |
+
Note that since recently PyTorch needs to be installed via pip. This is fine to do within your conda environment.
|
| 83 |
+
|
| 84 |
+
For Ubuntu with a Nvidia GPU, pick 'stable', 'Linux', 'Pip', 'Python', 'CUDA12.6' (if all drivers are up to date, otherwise use and older version):
|
| 85 |
+
|
| 86 |
+
```
|
| 87 |
+
pip3 install torch torchvision --index-url https://download.pytorch.org/whl/cu126
|
| 88 |
+
```
|
| 89 |
+
|
| 90 |
+
##### 3. Install this repository
|
| 91 |
+
Either install via pip:
|
| 92 |
+
`pip install nninteractive`
|
| 93 |
+
|
| 94 |
+
Or clone and install this repository:
|
| 95 |
+
```bash
|
| 96 |
+
git clone https://github.com/MIC-DKFZ/nnInteractive
|
| 97 |
+
cd nnInteractive
|
| 98 |
+
pip install -e .
|
| 99 |
+
```
|
| 100 |
+
|
| 101 |
+
## Getting Started
|
| 102 |
+
Here is a minimalistic script that covers the core functionality of nnInteractive:
|
| 103 |
+
|
| 104 |
+
```python
|
| 105 |
+
import os
|
| 106 |
+
import torch
|
| 107 |
+
import SimpleITK as sitk
|
| 108 |
+
from huggingface_hub import snapshot_download # Install huggingface_hub if not already installed
|
| 109 |
+
|
| 110 |
+
# --- Download Trained Model Weights (~400MB) ---
|
| 111 |
+
REPO_ID = "nnInteractive/nnInteractive"
|
| 112 |
+
MODEL_NAME = "nnInteractive_v1.0" # Updated models may be available in the future
|
| 113 |
+
DOWNLOAD_DIR = "/home/isensee/temp" # Specify the download directory
|
| 114 |
+
|
| 115 |
+
download_path = snapshot_download(
|
| 116 |
+
repo_id=REPO_ID,
|
| 117 |
+
allow_patterns=[f"{MODEL_NAME}/*"],
|
| 118 |
+
local_dir=DOWNLOAD_DIR
|
| 119 |
+
)
|
| 120 |
+
|
| 121 |
+
# The model is now stored in DOWNLOAD_DIR/MODEL_NAME.
|
| 122 |
+
|
| 123 |
+
# --- Initialize Inference Session ---
|
| 124 |
+
from nnInteractive.inference.inference_session import nnInteractiveInferenceSession
|
| 125 |
+
|
| 126 |
+
session = nnInteractiveInferenceSession(
|
| 127 |
+
device=torch.device("cuda:0"), # Set inference device
|
| 128 |
+
use_torch_compile=False, # Experimental: Not tested yet
|
| 129 |
+
verbose=False,
|
| 130 |
+
torch_n_threads=os.cpu_count(), # Use available CPU cores
|
| 131 |
+
do_autozoom=True, # Enables AutoZoom for better patching
|
| 132 |
+
use_pinned_memory=True, # Optimizes GPU memory transfers
|
| 133 |
+
)
|
| 134 |
+
|
| 135 |
+
# Load the trained model
|
| 136 |
+
model_path = os.path.join(DOWNLOAD_DIR, MODEL_NAME)
|
| 137 |
+
session.initialize_from_trained_model_folder(model_path)
|
| 138 |
+
|
| 139 |
+
# --- Load Input Image (Example with SimpleITK) ---
|
| 140 |
+
# DO NOT preprocess the image in any way. Give it to nnInteractive as it is! DO NOT apply level window, DO NOT normalize
|
| 141 |
+
# intensities and never ever convert an image with higher precision (float32, uint16, etc) to uint8!
|
| 142 |
+
# The ONLY instance where some preprocesing makes sense is if your original image is too large to be reasonably used.
|
| 143 |
+
# This may be the case, for example, for some microCT images. In this case you can consider downsampling.
|
| 144 |
+
input_image = sitk.ReadImage("FILENAME")
|
| 145 |
+
img = sitk.GetArrayFromImage(input_image)[None] # Ensure shape (1, x, y, z)
|
| 146 |
+
|
| 147 |
+
# Validate input dimensions
|
| 148 |
+
if img.ndim != 4:
|
| 149 |
+
raise ValueError("Input image must be 4D with shape (1, x, y, z)")
|
| 150 |
+
|
| 151 |
+
session.set_image(img)
|
| 152 |
+
|
| 153 |
+
# --- Define Output Buffer ---
|
| 154 |
+
target_tensor = torch.zeros(img.shape[1:], dtype=torch.uint8) # Must be 3D (x, y, z)
|
| 155 |
+
session.set_target_buffer(target_tensor)
|
| 156 |
+
|
| 157 |
+
# --- Interacting with the Model ---
|
| 158 |
+
# Interactions can be freely chained and mixed in any order. Each interaction refines the segmentation.
|
| 159 |
+
# The model updates the segmentation mask in the target buffer after every interaction.
|
| 160 |
+
|
| 161 |
+
# Example: Add a **positive** point interaction
|
| 162 |
+
# POINT_COORDINATES should be a tuple (x, y, z) specifying the point location.
|
| 163 |
+
session.add_point_interaction(POINT_COORDINATES, include_interaction=True)
|
| 164 |
+
|
| 165 |
+
# Example: Add a **negative** point interaction
|
| 166 |
+
# To make any interaction negative set include_interaction=False
|
| 167 |
+
session.add_point_interaction(POINT_COORDINATES, include_interaction=False)
|
| 168 |
+
|
| 169 |
+
# Example: Add a bounding box interaction
|
| 170 |
+
# BBOX_COORDINATES must be specified as [[x1, x2], [y1, y2], [z1, z2]] (half-open intervals).
|
| 171 |
+
# Note: nnInteractive pre-trained models currently only support **2D bounding boxes**.
|
| 172 |
+
# This means that **one dimension must be [d, d+1]** to indicate a single slice.
|
| 173 |
+
|
| 174 |
+
# Example of a 2D bounding box in the axial plane (XY slice at depth Z)
|
| 175 |
+
# BBOX_COORDINATES = [[30, 80], [40, 100], [10, 11]] # X: 30-80, Y: 40-100, Z: slice 10
|
| 176 |
+
|
| 177 |
+
session.add_bbox_interaction(BBOX_COORDINATES, include_interaction=True)
|
| 178 |
+
|
| 179 |
+
# Example: Add a scribble interaction
|
| 180 |
+
# - A 3D image of the same shape as img where one slice (any axis-aligned orientation) contains a hand-drawn scribble.
|
| 181 |
+
# - Background must be 0, and scribble must be 1.
|
| 182 |
+
# - Use session.preferred_scribble_thickness for optimal results.
|
| 183 |
+
session.add_scribble_interaction(SCRIBBLE_IMAGE, include_interaction=True)
|
| 184 |
+
|
| 185 |
+
# Example: Add a lasso interaction
|
| 186 |
+
# - Similarly to scribble a 3D image with a single slice containing a **closed contour** representing the selection.
|
| 187 |
+
session.add_lasso_interaction(LASSO_IMAGE, include_interaction=True)
|
| 188 |
+
|
| 189 |
+
# You can combine any number of interactions as needed.
|
| 190 |
+
# The model refines the segmentation result incrementally with each new interaction.
|
| 191 |
+
|
| 192 |
+
# --- Retrieve Results ---
|
| 193 |
+
# The target buffer holds the segmentation result.
|
| 194 |
+
results = session.target_buffer.clone()
|
| 195 |
+
# OR (equivalent)
|
| 196 |
+
results = target_tensor.clone()
|
| 197 |
+
|
| 198 |
+
# Cloning is required because the buffer will be **reused** for the next object.
|
| 199 |
+
# Alternatively, set a new target buffer for each object:
|
| 200 |
+
session.set_target_buffer(torch.zeros(img.shape[1:], dtype=torch.uint8))
|
| 201 |
+
|
| 202 |
+
# --- Start a New Object Segmentation ---
|
| 203 |
+
session.reset_interactions() # Clears the target buffer and resets interactions
|
| 204 |
+
|
| 205 |
+
# Now you can start segmenting the next object in the image.
|
| 206 |
+
|
| 207 |
+
# --- Set a New Image ---
|
| 208 |
+
# Setting a new image also requires setting a new matching target buffer
|
| 209 |
+
session.set_image(NEW_IMAGE)
|
| 210 |
+
session.set_target_buffer(torch.zeros(NEW_IMAGE.shape[1:], dtype=torch.uint8))
|
| 211 |
+
|
| 212 |
+
# Enjoy!
|
| 213 |
+
```
|
| 214 |
+
|
| 215 |
+
## nnInteractive SuperVoxels
|
| 216 |
+
|
| 217 |
+
As part of the `nnInteractive` framework, we provide a dedicated module for **supervoxel generation** based on [SAM](https://github.com/facebookresearch/segment-anything) and [SAM2](https://github.com/facebookresearch/sam2). This replaces traditional superpixel methods (e.g., SLIC) with **foundation model–powered 3D pseudo-labels**.
|
| 218 |
+
|
| 219 |
+
🔗 **Module:** [`nnInteractive/supervoxel/`](nnInteractive/supervoxel)
|
| 220 |
+
|
| 221 |
+
The SuperVoxel module allows you to:
|
| 222 |
+
|
| 223 |
+
- Automatically generate high-quality 3D supervoxels via axial sampling + SAM segmentation and SAM2 mask propagation.
|
| 224 |
+
- Use the generated supervoxels as **pseudo-ground-truth labels** to train promptable 3D segmentation models like `nnInteractive`.
|
| 225 |
+
- Export `nnUNet`-compatible `.pkl` foreground prompts for downstream use.
|
| 226 |
+
|
| 227 |
+
For detailed installation, configuration, and usage instructions, check the [SuperVoxel README](nnInteractive/supervoxel/README.md).
|
| 228 |
+
|
| 229 |
+
|
| 230 |
## Citation
|
| 231 |
When using nnInteractive, please cite the following paper:
|
| 232 |
|
|
|
|
| 237 |
|
| 238 |
|
| 239 |
# License
|
| 240 |
+
Note that while this repository is available under Apache-2.0 license (see [LICENSE](./LICENSE)), the [model checkpoint](https://huggingface.co/nnInteractive/nnInteractive) is `Creative Commons Attribution Non Commercial Share Alike 4.0`!
|
| 241 |
+
|
| 242 |
+
# Changelog
|
| 243 |
+
|
| 244 |
+
### 1.1.2 - 2025-08-02
|
| 245 |
+
|
| 246 |
+
- Fixed a bug where `pin_memory` was set to `True` even though no CUDA devices were present (this broke CPU support)
|
| 247 |
+
- ✅ API compatible all the way back to 1.0.1
|
| 248 |
+
|
| 249 |
+
### 1.1.1 - 2025-08-01
|
| 250 |
+
|
| 251 |
+
- We now detect whether linux kernel 6.11 is used and disable pin_memory in that case. See also [here](https://github.com/MIC-DKFZ/nnInteractive/issues/18)
|
| 252 |
+
- ✅ API compatible with 1.0.1 and 1.1.0
|
| 253 |
+
|
| 254 |
+
### 1.1.0 - 2025-08-01
|
| 255 |
+
|
| 256 |
+
- Reworked inference code. It's now well-structured and easier to follow.
|
| 257 |
+
- Fixed bugs that
|
| 258 |
+
- sometimes caused blocky predictions
|
| 259 |
+
- may cause failure to update segmentation map if changes were minor and AutoZoom was triggered
|
| 260 |
+
- ✅ API compatible with 1.0.1
|
| 261 |
|
| 262 |
## Acknowledgments
|
| 263 |
|