[
  {
    "query_id": "orph_test_00000",
    "question": "What is associated with Ear pain exacerbated by manipulating tragus or pinna?",
    "seeds": [
      "Ear pain exacerbated by manipulating tragus or pinna"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00001",
    "question": "What is associated with Oral erythroplakia?",
    "seeds": [
      "Oral erythroplakia"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00002",
    "question": "What is associated with Mirror image polydactyly?",
    "seeds": [
      "Mirror image polydactyly"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00003",
    "question": "What is associated with Retinal degeneration-nanophthalmos-glaucoma syndrome?",
    "seeds": [
      "Retinal degeneration-nanophthalmos-glaucoma syndrome"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00004",
    "question": "What is associated with Floating gallbladder?",
    "seeds": [
      "Floating gallbladder"
    ],
    "gold_answer": "Abnormality of the gallbladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00005",
    "question": "What is associated with Prolonged partial thromboplastin time?",
    "seeds": [
      "Prolonged partial thromboplastin time"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00006",
    "question": "What is associated with Pulmonary aterial intimal fibrosis?",
    "seeds": [
      "Pulmonary aterial intimal fibrosis"
    ],
    "gold_answer": "Abnormal pulmonary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00007",
    "question": "What is associated with Brown syndrome?",
    "seeds": [
      "Brown syndrome"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00008",
    "question": "What is associated with Griscelli syndrome type 3?",
    "seeds": [
      "Griscelli syndrome type 3"
    ],
    "gold_answer": "Abnormality of hair pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00009",
    "question": "What phenotype is associated with Bethlem myopathy 2?",
    "seeds": [
      "Bethlem myopathy 2"
    ],
    "gold_answer": "Proximal muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00010",
    "question": "What is associated with Microcephaly, primary autosomal recessive, 1?",
    "seeds": [
      "Microcephaly, primary autosomal recessive, 1"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00011",
    "question": "What is associated with Congenital giant melanocytic nevus?",
    "seeds": [
      "Congenital giant melanocytic nevus"
    ],
    "gold_answer": "Nevus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00012",
    "question": "What is associated with Scissor gait?",
    "seeds": [
      "Scissor gait"
    ],
    "gold_answer": "Spastic paraparetic gait",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00013",
    "question": "What is associated with Acute disseminated intravascular coagulation?",
    "seeds": [
      "Acute disseminated intravascular coagulation"
    ],
    "gold_answer": "Disseminated intravascular coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00014",
    "question": "What is associated with Sparse bone trabeculae?",
    "seeds": [
      "Sparse bone trabeculae"
    ],
    "gold_answer": "Abnormal bone structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00015",
    "question": "What is associated with Saccular aortic arch aneurysm?",
    "seeds": [
      "Saccular aortic arch aneurysm"
    ],
    "gold_answer": "Aortic arch aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00016",
    "question": "What phenotype is associated with DIASTEMATOMYELIA?",
    "seeds": [
      "DIASTEMATOMYELIA"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00017",
    "question": "What is associated with Sloping humeral metaphysis?",
    "seeds": [
      "Sloping humeral metaphysis"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00018",
    "question": "What is associated with Neurodegeneration, early-childhood-onset, with retinitis pigmentosa, sensorineural hearing loss, and demyelinating peripheral neuropathy?",
    "seeds": [
      "Neurodegeneration, early-childhood-onset, with retinitis pigmentosa, sensorineural hearing loss, and demyelinating peripheral neuropathy"
    ],
    "gold_answer": "Abnormal pupillary function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00019",
    "question": "What is associated with Fatigable weakness of swallowing muscles?",
    "seeds": [
      "Fatigable weakness of swallowing muscles"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00020",
    "question": "What is associated with Sclerosis of thumb phalanx?",
    "seeds": [
      "Sclerosis of thumb phalanx"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00021",
    "question": "What phenotype is associated with Achromatopsia 4?",
    "seeds": [
      "Achromatopsia 4"
    ],
    "gold_answer": "Achromatopsia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00022",
    "question": "What is associated with Nasal congestion?",
    "seeds": [
      "Nasal congestion"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00023",
    "question": "What is associated with Diaphragmatic eventration?",
    "seeds": [
      "Diaphragmatic eventration"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00024",
    "question": "What is associated with Thumb deformity-alopecia-pigmentation anomaly syndrome?",
    "seeds": [
      "Thumb deformity-alopecia-pigmentation anomaly syndrome"
    ],
    "gold_answer": "Syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00025",
    "question": "What is associated with Brain abscess?",
    "seeds": [
      "Brain abscess"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00026",
    "question": "What is associated with Toxemia of pregnancy?",
    "seeds": [
      "Toxemia of pregnancy"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00027",
    "question": "What is associated with Failure to increase oxygen saturation on hyperoxia test?",
    "seeds": [
      "Failure to increase oxygen saturation on hyperoxia test"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00028",
    "question": "What is associated with Autoimmune hepatitis?",
    "seeds": [
      "Autoimmune hepatitis"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00029",
    "question": "What phenotype is associated with Björnstad syndrome?",
    "seeds": [
      "Björnstad syndrome"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00030",
    "question": "What is associated with Sandhoff disease?",
    "seeds": [
      "Sandhoff disease"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00031",
    "question": "What is associated with Dyskeratosis, hereditary benign intraepithelial?",
    "seeds": [
      "Dyskeratosis, hereditary benign intraepithelial"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00032",
    "question": "What is associated with Maternal diabetes?",
    "seeds": [
      "Maternal diabetes"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00033",
    "question": "What is associated with Endogenous lipoid pneumonia?",
    "seeds": [
      "Endogenous lipoid pneumonia"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00034",
    "question": "What is associated with Mucinous colorectal carcinoma?",
    "seeds": [
      "Mucinous colorectal carcinoma"
    ],
    "gold_answer": "Glandular cell neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00035",
    "question": "What is associated with Milroy disease?",
    "seeds": [
      "Milroy disease"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00036",
    "question": "What phenotype is associated with Achondrogenesis, type IB?",
    "seeds": [
      "Achondrogenesis, type IB"
    ],
    "gold_answer": "Generalized edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00037",
    "question": "What is associated with Fractured manual digit bone?",
    "seeds": [
      "Fractured manual digit bone"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00038",
    "question": "What phenotype is associated with Neurodevelopmental disorder with early-onset seizures, facial dysmorphism, and behavioral abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with early-onset seizures, facial dysmorphism, and behavioral abnormalities"
    ],
    "gold_answer": "Small forehead",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00039",
    "question": "What is associated with Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis?",
    "seeds": [
      "Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00040",
    "question": "What phenotype is associated with 2q37 microdeletion syndrome?",
    "seeds": [
      "2q37 microdeletion syndrome"
    ],
    "gold_answer": "Thin vermilion border",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00041",
    "question": "What phenotype is associated with Cardiac, facial, and digital anomalies with developmental delay?",
    "seeds": [
      "Cardiac, facial, and digital anomalies with developmental delay"
    ],
    "gold_answer": "Unusual CNS infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00042",
    "question": "What is associated with Splenic rupture?",
    "seeds": [
      "Splenic rupture"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00043",
    "question": "What phenotype is associated with Neutropenia, severe congenital, 8, autosomal dominant?",
    "seeds": [
      "Neutropenia, severe congenital, 8, autosomal dominant"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00044",
    "question": "What phenotype is associated with Neurodegeneration with brain iron accumulation 1?",
    "seeds": [
      "Neurodegeneration with brain iron accumulation 1"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00045",
    "question": "What is associated with Microcephaly 3, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 3, primary, autosomal recessive"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00046",
    "question": "What is associated with Melanoma-Astrocytoma syndrome?",
    "seeds": [
      "Melanoma-Astrocytoma syndrome"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00047",
    "question": "What is associated with Reduced muscle dystrophin expression?",
    "seeds": [
      "Reduced muscle dystrophin expression"
    ],
    "gold_answer": "Abnormal muscle fiber dystrophin expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00048",
    "question": "What is associated with Triggered by vaccination?",
    "seeds": [
      "Triggered by vaccination"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00049",
    "question": "What is associated with Pulmonary hemorrhage?",
    "seeds": [
      "Pulmonary hemorrhage"
    ],
    "gold_answer": "Internal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00050",
    "question": "What is associated with Prominent interphalangeal joints?",
    "seeds": [
      "Prominent interphalangeal joints"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00051",
    "question": "What is associated with Abnormal ovarian morphology?",
    "seeds": [
      "Abnormal ovarian morphology"
    ],
    "gold_answer": "Abnormality of the female genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00052",
    "question": "What is associated with 1-4 finger cutaneous syndactyly?",
    "seeds": [
      "1-4 finger cutaneous syndactyly"
    ],
    "gold_answer": "Cutaneous finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00053",
    "question": "What is associated with Abnormal greater sciatic notch morphology?",
    "seeds": [
      "Abnormal greater sciatic notch morphology"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00054",
    "question": "What is associated with Nephronophthisis 2?",
    "seeds": [
      "Nephronophthisis 2"
    ],
    "gold_answer": "Abnormal circulating potassium concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00055",
    "question": "What is associated with Mandibulofacial dysostosis?",
    "seeds": [
      "Mandibulofacial dysostosis"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00056",
    "question": "What phenotype is associated with Ovarian fibromata?",
    "seeds": [
      "Ovarian fibromata"
    ],
    "gold_answer": "Ovarian fibroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00057",
    "question": "What is associated with Smith-Magenis syndrome?",
    "seeds": [
      "Smith-Magenis syndrome"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00058",
    "question": "What is associated with Decreased complex N-glycan level?",
    "seeds": [
      "Decreased complex N-glycan level"
    ],
    "gold_answer": "Abnormal protein N-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00059",
    "question": "What is associated with Tubular microcystic change?",
    "seeds": [
      "Tubular microcystic change"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00060",
    "question": "What is associated with Abnormal circulating immunoglobulin concentration?",
    "seeds": [
      "Abnormal circulating immunoglobulin concentration"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00061",
    "question": "What is associated with Small epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Small epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Small epiphyses of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00062",
    "question": "What is associated with Renal intimal/medial arteriolitis?",
    "seeds": [
      "Renal intimal/medial arteriolitis"
    ],
    "gold_answer": "Abnormal renal arteriole morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00063",
    "question": "What is associated with Hyperplasia of the femoral trochanters?",
    "seeds": [
      "Hyperplasia of the femoral trochanters"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00064",
    "question": "What is associated with Hallux dorsiflexion weakness?",
    "seeds": [
      "Hallux dorsiflexion weakness"
    ],
    "gold_answer": "Limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00065",
    "question": "What is associated with Anti-DPPX antibody?",
    "seeds": [
      "Anti-DPPX antibody"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00066",
    "question": "What is associated with Thumb deformity?",
    "seeds": [
      "Thumb deformity"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00067",
    "question": "What is associated with Dislocated radial head?",
    "seeds": [
      "Dislocated radial head"
    ],
    "gold_answer": "Abnormality of the radial head",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00068",
    "question": "What is associated with Pulmonic stenosis?",
    "seeds": [
      "Pulmonic stenosis"
    ],
    "gold_answer": "Abnormal heart valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00069",
    "question": "What is associated with Decreased circulating transcobalamin II concentration?",
    "seeds": [
      "Decreased circulating transcobalamin II concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00070",
    "question": "What is associated with Unilateral deafness?",
    "seeds": [
      "Unilateral deafness"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00071",
    "question": "What is associated with Myxomatous mitral valve degeneration?",
    "seeds": [
      "Myxomatous mitral valve degeneration"
    ],
    "gold_answer": "Mitral valve prolapse",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00072",
    "question": "What phenotype is associated with Distal deletion 12q syndrome?",
    "seeds": [
      "Distal deletion 12q syndrome"
    ],
    "gold_answer": "Subglottic stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00073",
    "question": "What is associated with Chromosome 3q29 deletion syndrome?",
    "seeds": [
      "Chromosome 3q29 deletion syndrome"
    ],
    "gold_answer": "Abnormal 5th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00074",
    "question": "What is associated with Deep palmar crease?",
    "seeds": [
      "Deep palmar crease"
    ],
    "gold_answer": "Abnormality of the palmar creases",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00075",
    "question": "What is associated with Thickened mitral valve cusp?",
    "seeds": [
      "Thickened mitral valve cusp"
    ],
    "gold_answer": "Abnormal mitral valve leaflet morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00076",
    "question": "What is associated with Fructose intolerance?",
    "seeds": [
      "Fructose intolerance"
    ],
    "gold_answer": "Abnormal metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00077",
    "question": "What phenotype is associated with Alopecia-intellectual disability syndrome 4?",
    "seeds": [
      "Alopecia-intellectual disability syndrome 4"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00078",
    "question": "What is associated with Carcinoid tumor of the pancreas?",
    "seeds": [
      "Carcinoid tumor of the pancreas"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00079",
    "question": "What is associated with Mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly?",
    "seeds": [
      "Mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly"
    ],
    "gold_answer": "Abdominal wall defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00080",
    "question": "What is associated with 3-hydroxydicarboxylic aciduria?",
    "seeds": [
      "3-hydroxydicarboxylic aciduria"
    ],
    "gold_answer": "Dicarboxylic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00081",
    "question": "What phenotype is associated with Monosomy 7 myelodysplasia and leukemia syndrome 2?",
    "seeds": [
      "Monosomy 7 myelodysplasia and leukemia syndrome 2"
    ],
    "gold_answer": "Decreased total neutrophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00082",
    "question": "What phenotype is associated with Renal agenesis, bilateral?",
    "seeds": [
      "Renal agenesis, bilateral"
    ],
    "gold_answer": "Spina bifida",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00083",
    "question": "What is associated with Hodgkin lymphoma?",
    "seeds": [
      "Hodgkin lymphoma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00084",
    "question": "What is associated with Broad 2nd toe?",
    "seeds": [
      "Broad 2nd toe"
    ],
    "gold_answer": "Broad toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00085",
    "question": "What phenotype is associated with Citrullinemia, type II, neonatal-onset?",
    "seeds": [
      "Citrullinemia, type II, neonatal-onset"
    ],
    "gold_answer": "Mild global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00086",
    "question": "What is associated with Abnormal circulating glutamine family amino acid concentration?",
    "seeds": [
      "Abnormal circulating glutamine family amino acid concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00087",
    "question": "What is associated with Recurrent bronchopulmonary infections?",
    "seeds": [
      "Recurrent bronchopulmonary infections"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00088",
    "question": "What is associated with Global developmental delay with or without impaired intellectual development?",
    "seeds": [
      "Global developmental delay with or without impaired intellectual development"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00089",
    "question": "What is associated with Ascending tubular aorta aneurysm?",
    "seeds": [
      "Ascending tubular aorta aneurysm"
    ],
    "gold_answer": "Thoracic aortic aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00090",
    "question": "What is associated with Thyroid follicular hyperplasia?",
    "seeds": [
      "Thyroid follicular hyperplasia"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00091",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2II?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2II"
    ],
    "gold_answer": "Hand muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00092",
    "question": "What phenotype is associated with Mitochondrial complex V (ATP synthase) deficiency, nuclear type 7?",
    "seeds": [
      "Mitochondrial complex V (ATP synthase) deficiency, nuclear type 7"
    ],
    "gold_answer": "Brain atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00093",
    "question": "What phenotype is associated with NONDISJUNCTION?",
    "seeds": [
      "NONDISJUNCTION"
    ],
    "gold_answer": "Abnormality of chromosome segregation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00094",
    "question": "What phenotype is associated with Athyreosis?",
    "seeds": [
      "Athyreosis"
    ],
    "gold_answer": "Facial edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00095",
    "question": "What is associated with Muscular dystrophy, limb-girdle, type 2D?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, type 2D"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00096",
    "question": "What is associated with Retinal telangiectasia?",
    "seeds": [
      "Retinal telangiectasia"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00097",
    "question": "What is associated with Abnormal CSF aspartate family amino acid concentration?",
    "seeds": [
      "Abnormal CSF aspartate family amino acid concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00098",
    "question": "What is associated with Non-necrotizing pulmonary granulomatosis?",
    "seeds": [
      "Non-necrotizing pulmonary granulomatosis"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00099",
    "question": "What is associated with Herpetiform?",
    "seeds": [
      "Herpetiform"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00100",
    "question": "What is associated with Reversible renal failure?",
    "seeds": [
      "Reversible renal failure"
    ],
    "gold_answer": "Renal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00101",
    "question": "What is associated with Linear earlobe crease?",
    "seeds": [
      "Linear earlobe crease"
    ],
    "gold_answer": "Abnormal earlobe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00102",
    "question": "What is associated with Fragile X syndrome?",
    "seeds": [
      "Fragile X syndrome"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00103",
    "question": "What phenotype is associated with Deafness, autosomal recessive 29?",
    "seeds": [
      "Deafness, autosomal recessive 29"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00104",
    "question": "What is associated with Abnormality of the epiphysis of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Abnormality of the epiphysis of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00105",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 46?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 46"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00106",
    "question": "What is associated with Mayer-Rokitansky-Kuster-Hauser syndrome?",
    "seeds": [
      "Mayer-Rokitansky-Kuster-Hauser syndrome"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00107",
    "question": "What is associated with Peroneal tendon subluxation?",
    "seeds": [
      "Peroneal tendon subluxation"
    ],
    "gold_answer": "Abnormality of the ankle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00108",
    "question": "What is associated with Abnormal cortical radial artery lumen morphology?",
    "seeds": [
      "Abnormal cortical radial artery lumen morphology"
    ],
    "gold_answer": "Abnormal renal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00109",
    "question": "What is associated with Neonatal insulin-dependent diabetes mellitus?",
    "seeds": [
      "Neonatal insulin-dependent diabetes mellitus"
    ],
    "gold_answer": "Insulin resistance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00110",
    "question": "What is associated with Skin creases, congenital symmetric circumferential, 1?",
    "seeds": [
      "Skin creases, congenital symmetric circumferential, 1"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00111",
    "question": "What is associated with Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation?",
    "seeds": [
      "Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation"
    ],
    "gold_answer": "TFG",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_test_00112",
    "question": "What is associated with Coronary cameral fistula to right ventricle?",
    "seeds": [
      "Coronary cameral fistula to right ventricle"
    ],
    "gold_answer": "Abnormal coronary artery course",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00113",
    "question": "What is associated with Deficiency of N-acetylglucosamine-1-phosphotransferase?",
    "seeds": [
      "Deficiency of N-acetylglucosamine-1-phosphotransferase"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00114",
    "question": "What phenotype is associated with Lethal congenital contracture syndrome 10?",
    "seeds": [
      "Lethal congenital contracture syndrome 10"
    ],
    "gold_answer": "Increased placental thickness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00115",
    "question": "What is associated with Pseudodiastrophic dysplasia?",
    "seeds": [
      "Pseudodiastrophic dysplasia"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00116",
    "question": "What is associated with Multicentric ossification of proximal humeral epiphyses?",
    "seeds": [
      "Multicentric ossification of proximal humeral epiphyses"
    ],
    "gold_answer": "Abnormal humeral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00117",
    "question": "What phenotype is associated with Premature ovarian failure 18?",
    "seeds": [
      "Premature ovarian failure 18"
    ],
    "gold_answer": "Premature ovarian insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00118",
    "question": "What is associated with Microcornea-glaucoma-absent frontal sinuses syndrome?",
    "seeds": [
      "Microcornea-glaucoma-absent frontal sinuses syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the frontal sinuses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00119",
    "question": "What is associated with Arcuate artery endoarterial hypercellularity?",
    "seeds": [
      "Arcuate artery endoarterial hypercellularity"
    ],
    "gold_answer": "Abnormal intrarenal artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00120",
    "question": "What is associated with Chondrodysplasia, Blomstrand type?",
    "seeds": [
      "Chondrodysplasia, Blomstrand type"
    ],
    "gold_answer": "Abnormal larynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00121",
    "question": "What phenotype is associated with Cataract 44?",
    "seeds": [
      "Cataract 44"
    ],
    "gold_answer": "Developmental cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00122",
    "question": "What is associated with Abnormality of bone marrow stromal cells?",
    "seeds": [
      "Abnormality of bone marrow stromal cells"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00123",
    "question": "What is associated with Abnormal isohemagglutinin level?",
    "seeds": [
      "Abnormal isohemagglutinin level"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00124",
    "question": "What is associated with Thickened intrahepatic portal venules?",
    "seeds": [
      "Thickened intrahepatic portal venules"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00125",
    "question": "What is associated with Abnormal sperm neck morphology?",
    "seeds": [
      "Abnormal sperm neck morphology"
    ],
    "gold_answer": "Abnormal germ cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00126",
    "question": "What is associated with Absent pulmonary artery?",
    "seeds": [
      "Absent pulmonary artery"
    ],
    "gold_answer": "Abnormal pulmonary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00127",
    "question": "What is associated with Dystonia 17, torsion, autosomal recessive?",
    "seeds": [
      "Dystonia 17, torsion, autosomal recessive"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00128",
    "question": "What is associated with Absence of acoustic reflex?",
    "seeds": [
      "Absence of acoustic reflex"
    ],
    "gold_answer": "Abnormality of the acoustic reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00129",
    "question": "What phenotype is associated with Retinitis pigmentosa 10?",
    "seeds": [
      "Retinitis pigmentosa 10"
    ],
    "gold_answer": "Optic disc pallor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00130",
    "question": "What is associated with Macular dots?",
    "seeds": [
      "Macular dots"
    ],
    "gold_answer": "Yellow/white macular lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00131",
    "question": "What is associated with Arthrogryposis multiplex congenita 5?",
    "seeds": [
      "Arthrogryposis multiplex congenita 5"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00132",
    "question": "What is associated with Sloping humeral metaphysis?",
    "seeds": [
      "Sloping humeral metaphysis"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00133",
    "question": "What is associated with Microangiopathy and leukoencephalopathy, pontine, autosomal dominant?",
    "seeds": [
      "Microangiopathy and leukoencephalopathy, pontine, autosomal dominant"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00134",
    "question": "What is associated with Increased multinucleated megakaryocyte count?",
    "seeds": [
      "Increased multinucleated megakaryocyte count"
    ],
    "gold_answer": "Abnormal megakaryocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00135",
    "question": "What is associated with Localized skin lesion?",
    "seeds": [
      "Localized skin lesion"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00136",
    "question": "What phenotype is associated with Platyspondylic dysplasia, Torrance type?",
    "seeds": [
      "Platyspondylic dysplasia, Torrance type"
    ],
    "gold_answer": "Depressed nasal bridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00137",
    "question": "What is associated with Esophageal furrows?",
    "seeds": [
      "Esophageal furrows"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00138",
    "question": "What is associated with Lissencephaly 9 with complex brainstem malformation?",
    "seeds": [
      "Lissencephaly 9 with complex brainstem malformation"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00139",
    "question": "What is associated with Fetal cerebellar vermis hemorrhage?",
    "seeds": [
      "Fetal cerebellar vermis hemorrhage"
    ],
    "gold_answer": "Fetal intracranial hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00140",
    "question": "What phenotype is associated with Patella aplasia-hypoplasia?",
    "seeds": [
      "Patella aplasia-hypoplasia"
    ],
    "gold_answer": "Patellar hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00141",
    "question": "What is associated with Anti-mitochondrial M2 antibody positivity?",
    "seeds": [
      "Anti-mitochondrial M2 antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00142",
    "question": "What is associated with EEG with generalized spikes?",
    "seeds": [
      "EEG with generalized spikes"
    ],
    "gold_answer": "EEG with generalized epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00143",
    "question": "What is associated with Meningocele?",
    "seeds": [
      "Meningocele"
    ],
    "gold_answer": "Closed neural tube defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00144",
    "question": "What is associated with Abnormal sarcomere morphology?",
    "seeds": [
      "Abnormal sarcomere morphology"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00145",
    "question": "What is associated with Pulmonary infiltrates?",
    "seeds": [
      "Pulmonary infiltrates"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00146",
    "question": "What is associated with Pulmonary hypertension, primary, 4?",
    "seeds": [
      "Pulmonary hypertension, primary, 4"
    ],
    "gold_answer": "Bundle branch block",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00147",
    "question": "What is associated with Marie Unna hereditary hypotrichosis?",
    "seeds": [
      "Marie Unna hereditary hypotrichosis"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00148",
    "question": "What phenotype is associated with Hereditary angioedema with C1Inh deficiency?",
    "seeds": [
      "Hereditary angioedema with C1Inh deficiency"
    ],
    "gold_answer": "Diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00149",
    "question": "What phenotype is associated with Chromosome 16q12 duplication syndrome?",
    "seeds": [
      "Chromosome 16q12 duplication syndrome"
    ],
    "gold_answer": "Temporal optic disc pallor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00150",
    "question": "What is associated with Thyroglossal cyst?",
    "seeds": [
      "Thyroglossal cyst"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00151",
    "question": "What is associated with Elevated circulating methysterol concentration?",
    "seeds": [
      "Elevated circulating methysterol concentration"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00152",
    "question": "What is associated with Epilepsy, familial adult myoclonic, 4?",
    "seeds": [
      "Epilepsy, familial adult myoclonic, 4"
    ],
    "gold_answer": "Abnormal nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00153",
    "question": "What is associated with Small epiphysis of the distal phalanx of the 5th toe?",
    "seeds": [
      "Small epiphysis of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00154",
    "question": "What is associated with Nevus comedonicus, somatic?",
    "seeds": [
      "Nevus comedonicus, somatic"
    ],
    "gold_answer": "Nevus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00155",
    "question": "What phenotype is associated with Ectodermal dysplasia/skin fragility syndrome?",
    "seeds": [
      "Ectodermal dysplasia/skin fragility syndrome"
    ],
    "gold_answer": "Ectodermal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00156",
    "question": "What is associated with Triggered by febrile illness?",
    "seeds": [
      "Triggered by febrile illness"
    ],
    "gold_answer": "Triggered by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00157",
    "question": "What is associated with Spondylocostal dysostosis 6, autosomal recessive?",
    "seeds": [
      "Spondylocostal dysostosis 6, autosomal recessive"
    ],
    "gold_answer": "Abnormal cervical spine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00158",
    "question": "What is associated with Neoplasm of the adrenal medulla?",
    "seeds": [
      "Neoplasm of the adrenal medulla"
    ],
    "gold_answer": "Neoplasm of the adrenal gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00159",
    "question": "What is associated with Pseudoaminopterin syndrome?",
    "seeds": [
      "Pseudoaminopterin syndrome"
    ],
    "gold_answer": "Abnormal localization of kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00160",
    "question": "What is associated with Long fingers?",
    "seeds": [
      "Long fingers"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00161",
    "question": "What is associated with Myasthenic syndrome, congenital, 15?",
    "seeds": [
      "Myasthenic syndrome, congenital, 15"
    ],
    "gold_answer": "Functional motor deficit",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00162",
    "question": "What is associated with Thyrotoxic periodic paralysis, susceptibility to, 2?",
    "seeds": [
      "Thyrotoxic periodic paralysis, susceptibility to, 2"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00163",
    "question": "What is associated with Localized skin lesion?",
    "seeds": [
      "Localized skin lesion"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00164",
    "question": "What is associated with Hypoplasia of the pyramidal tract?",
    "seeds": [
      "Hypoplasia of the pyramidal tract"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00165",
    "question": "What phenotype is associated with Fanconi anemia, complementation group P?",
    "seeds": [
      "Fanconi anemia, complementation group P"
    ],
    "gold_answer": "Pelvic kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00166",
    "question": "What phenotype is associated with Sturge-Weber syndrome?",
    "seeds": [
      "Sturge-Weber syndrome"
    ],
    "gold_answer": "Blindness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00167",
    "question": "What is associated with Bladder stones?",
    "seeds": [
      "Bladder stones"
    ],
    "gold_answer": "Abnormal bladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00168",
    "question": "What phenotype is associated with Uruguay faciocardiomusculoskeletal syndrome?",
    "seeds": [
      "Uruguay faciocardiomusculoskeletal syndrome"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00169",
    "question": "What is associated with Cognitive epileptic aura?",
    "seeds": [
      "Cognitive epileptic aura"
    ],
    "gold_answer": "Epileptic aura",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00170",
    "question": "What is associated with Abnormal ventricular axis?",
    "seeds": [
      "Abnormal ventricular axis"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00171",
    "question": "What is associated with Polydactyly, preaxial IV?",
    "seeds": [
      "Polydactyly, preaxial IV"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00172",
    "question": "What is associated with Mosaic trisomy 9 syndrome?",
    "seeds": [
      "Mosaic trisomy 9 syndrome"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00173",
    "question": "What phenotype is associated with Microcephaly, congenital cataract, and psoriasiform dermatitis?",
    "seeds": [
      "Microcephaly, congenital cataract, and psoriasiform dermatitis"
    ],
    "gold_answer": "Elevated circulating methysterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00174",
    "question": "What is associated with Duplication of phalanx of hallux?",
    "seeds": [
      "Duplication of phalanx of hallux"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00175",
    "question": "What is associated with Hypomagnesemia 7, renal, with or without dilated cardiomyopathy?",
    "seeds": [
      "Hypomagnesemia 7, renal, with or without dilated cardiomyopathy"
    ],
    "gold_answer": "Abnormal urine output",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00176",
    "question": "What phenotype is associated with Waardenburg syndrome, type 3?",
    "seeds": [
      "Waardenburg syndrome, type 3"
    ],
    "gold_answer": "Short palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00177",
    "question": "What is associated with Abnormal timing of dark-adapted bright flash electroretinogram?",
    "seeds": [
      "Abnormal timing of dark-adapted bright flash electroretinogram"
    ],
    "gold_answer": "Abnormal dark-adapted bright flash electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00178",
    "question": "What is associated with Posterior fossa cyst at the fourth ventricle?",
    "seeds": [
      "Posterior fossa cyst at the fourth ventricle"
    ],
    "gold_answer": "Intracranial cystic lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00179",
    "question": "What phenotype is associated with Spinocerebellar ataxia with epilepsy?",
    "seeds": [
      "Spinocerebellar ataxia with epilepsy"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00180",
    "question": "What is associated with Melanoma-Astrocytoma syndrome?",
    "seeds": [
      "Melanoma-Astrocytoma syndrome"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00181",
    "question": "What is associated with Hypogonadotropic hypogonadism 10 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 10 with or without anosmia"
    ],
    "gold_answer": "Hypogonadism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00182",
    "question": "What is associated with Maturity-onset diabetes of the young, type 10?",
    "seeds": [
      "Maturity-onset diabetes of the young, type 10"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00183",
    "question": "What is associated with Recurrent singultus?",
    "seeds": [
      "Recurrent singultus"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00184",
    "question": "What is associated with Fractured left clavicle?",
    "seeds": [
      "Fractured left clavicle"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00185",
    "question": "What is associated with Total absence of the pericardium?",
    "seeds": [
      "Total absence of the pericardium"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00186",
    "question": "What is associated with Estrogen resistance?",
    "seeds": [
      "Estrogen resistance"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00187",
    "question": "What is associated with Prolonged P wave?",
    "seeds": [
      "Prolonged P wave"
    ],
    "gold_answer": "Abnormal P wave",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00188",
    "question": "What is associated with Dialeptic seizure?",
    "seeds": [
      "Dialeptic seizure"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00189",
    "question": "What is associated with Hypoplastic carotid canal?",
    "seeds": [
      "Hypoplastic carotid canal"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00190",
    "question": "What is associated with Spinocerebellar ataxia 32?",
    "seeds": [
      "Spinocerebellar ataxia 32"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00191",
    "question": "What is associated with Thyroid nodule?",
    "seeds": [
      "Thyroid nodule"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00192",
    "question": "What is associated with Recurrent coughing spasms?",
    "seeds": [
      "Recurrent coughing spasms"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00193",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 54?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 54"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the optic nerve",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00194",
    "question": "What is associated with Extrahepatic bile duct fibrosis?",
    "seeds": [
      "Extrahepatic bile duct fibrosis"
    ],
    "gold_answer": "Abnormal extrahepatic bile duct morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00195",
    "question": "What is associated with Pulmonic regurgitation?",
    "seeds": [
      "Pulmonic regurgitation"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00196",
    "question": "What is associated with Polydactyly, preaxial II?",
    "seeds": [
      "Polydactyly, preaxial II"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00197",
    "question": "What is associated with Infection-related hemolytic uremic syndrome?",
    "seeds": [
      "Infection-related hemolytic uremic syndrome"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00198",
    "question": "What phenotype is associated with Greig cephalopolysyndactyly syndrome?",
    "seeds": [
      "Greig cephalopolysyndactyly syndrome"
    ],
    "gold_answer": "Broad hallux phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00199",
    "question": "What phenotype is associated with KELOIDS?",
    "seeds": [
      "KELOIDS"
    ],
    "gold_answer": "Keloids",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00200",
    "question": "What is associated with Elevated circulating guanidinoacetic acid concentration?",
    "seeds": [
      "Elevated circulating guanidinoacetic acid concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00201",
    "question": "What is associated with Pituitary spindle cell oncocytoma?",
    "seeds": [
      "Pituitary spindle cell oncocytoma"
    ],
    "gold_answer": "Neoplasm of the pituitary gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00202",
    "question": "What phenotype is associated with Cognitive impairment with or without cerebellar ataxia?",
    "seeds": [
      "Cognitive impairment with or without cerebellar ataxia"
    ],
    "gold_answer": "Cerebellar atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00203",
    "question": "What is associated with Corneal dystrophy, congenital stromal?",
    "seeds": [
      "Corneal dystrophy, congenital stromal"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00204",
    "question": "What is associated with Paravertebral mass?",
    "seeds": [
      "Paravertebral mass"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00205",
    "question": "What is associated with Cataract 46, juvenile-onset?",
    "seeds": [
      "Cataract 46, juvenile-onset"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00206",
    "question": "What is associated with Progressive external ophthalmoplegia-myopathy-emaciation syndrome?",
    "seeds": [
      "Progressive external ophthalmoplegia-myopathy-emaciation syndrome"
    ],
    "gold_answer": "Weakness of muscles of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00207",
    "question": "What is associated with Cherry red spot of the macula?",
    "seeds": [
      "Cherry red spot of the macula"
    ],
    "gold_answer": "Abnormal head blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00208",
    "question": "What is associated with Decreased serum zinc?",
    "seeds": [
      "Decreased serum zinc"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00209",
    "question": "What is associated with Reduced lysosomal acid lipase activity?",
    "seeds": [
      "Reduced lysosomal acid lipase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00210",
    "question": "What is associated with Non-convulsive status epilepticus with coma?",
    "seeds": [
      "Non-convulsive status epilepticus with coma"
    ],
    "gold_answer": "Status epilepticus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00211",
    "question": "What is associated with Abnormal interlobular vein morphology?",
    "seeds": [
      "Abnormal interlobular vein morphology"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00212",
    "question": "What phenotype is associated with Splenomegaly, cytopenia, and vision loss?",
    "seeds": [
      "Splenomegaly, cytopenia, and vision loss"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00213",
    "question": "What is associated with Preauricular cyst?",
    "seeds": [
      "Preauricular cyst"
    ],
    "gold_answer": "Abnormal periauricular region morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00214",
    "question": "What is associated with Elevated circulating methysterol concentration?",
    "seeds": [
      "Elevated circulating methysterol concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00215",
    "question": "What is associated with Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia?",
    "seeds": [
      "Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00216",
    "question": "What is associated with Impaired binding of factor VIII to VWF?",
    "seeds": [
      "Impaired binding of factor VIII to VWF"
    ],
    "gold_answer": "Abnormality of von Willebrand factor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00217",
    "question": "What is associated with Supraventricular tachycardia with a manifest accessory pathway on the right free wall?",
    "seeds": [
      "Supraventricular tachycardia with a manifest accessory pathway on the right free wall"
    ],
    "gold_answer": "Supraventricular tachycardia with an accessory connection mediated pathway",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00218",
    "question": "What is associated with Mesomelic/rhizomelic limb shortening?",
    "seeds": [
      "Mesomelic/rhizomelic limb shortening"
    ],
    "gold_answer": "Rhizomelia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00219",
    "question": "What is associated with Primrose syndrome?",
    "seeds": [
      "Primrose syndrome"
    ],
    "gold_answer": "Thick vermilion border",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00220",
    "question": "What phenotype is associated with Retinopathy of prematurity?",
    "seeds": [
      "Retinopathy of prematurity"
    ],
    "gold_answer": "Small for gestational age",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00221",
    "question": "What is associated with Fetal extra-axial hemorrhage?",
    "seeds": [
      "Fetal extra-axial hemorrhage"
    ],
    "gold_answer": "Abnormal fetal central nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00222",
    "question": "What is associated with Camptosynpolydactyly, complex?",
    "seeds": [
      "Camptosynpolydactyly, complex"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00223",
    "question": "What is associated with Moderate postnatal growth retardation?",
    "seeds": [
      "Moderate postnatal growth retardation"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00224",
    "question": "What is associated with Abnormal circulating interleukin 6 concentration?",
    "seeds": [
      "Abnormal circulating interleukin 6 concentration"
    ],
    "gold_answer": "Abnormal immune serum protein physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00225",
    "question": "What is associated with Xq25 microduplication syndrome?",
    "seeds": [
      "Xq25 microduplication syndrome"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00226",
    "question": "What is associated with Muscle filaminopathy?",
    "seeds": [
      "Muscle filaminopathy"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00227",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 35?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 35"
    ],
    "gold_answer": "Delayed CNS myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00228",
    "question": "What is associated with Increased carrying angle?",
    "seeds": [
      "Increased carrying angle"
    ],
    "gold_answer": "Abnormality of the elbow",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00229",
    "question": "What is associated with Comma-shaped carpal bones?",
    "seeds": [
      "Comma-shaped carpal bones"
    ],
    "gold_answer": "Abnormal wrist morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00230",
    "question": "What is associated with Mid-frequency hearing loss?",
    "seeds": [
      "Mid-frequency hearing loss"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00231",
    "question": "What is associated with Myocardial sarcomeric disarray?",
    "seeds": [
      "Myocardial sarcomeric disarray"
    ],
    "gold_answer": "Abnormal cardiomyocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00232",
    "question": "What is associated with Abnormal circulating alpha-fetoprotein concentration?",
    "seeds": [
      "Abnormal circulating alpha-fetoprotein concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00233",
    "question": "What phenotype is associated with Spondyloepimetaphyseal dysplasia, X-linked, with mental deterioration?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, X-linked, with mental deterioration"
    ],
    "gold_answer": "Wormian bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00234",
    "question": "What is associated with Decreased glucosephosphate isomerase level?",
    "seeds": [
      "Decreased glucosephosphate isomerase level"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00235",
    "question": "What is associated with Increased circulating androgen concentration?",
    "seeds": [
      "Increased circulating androgen concentration"
    ],
    "gold_answer": "Abnormal circulating sex hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00236",
    "question": "What is associated with Cholestasis?",
    "seeds": [
      "Cholestasis"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00237",
    "question": "What is associated with MFF-related encephalopathy due to mitochondrial and peroxisomal fission defect?",
    "seeds": [
      "MFF-related encephalopathy due to mitochondrial and peroxisomal fission defect"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00238",
    "question": "What is associated with Autoinflammatory syndrome, familial, Behcet-like?",
    "seeds": [
      "Autoinflammatory syndrome, familial, Behcet-like"
    ],
    "gold_answer": "Gastrointestinal inflammation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00239",
    "question": "What is associated with Miyoshi muscular dystrophy 1?",
    "seeds": [
      "Miyoshi muscular dystrophy 1"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00240",
    "question": "What is associated with Crystalluria?",
    "seeds": [
      "Crystalluria"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00241",
    "question": "What phenotype is associated with Alveolar capillary dysplasia with misalignment of pulmonary veins?",
    "seeds": [
      "Alveolar capillary dysplasia with misalignment of pulmonary veins"
    ],
    "gold_answer": "Coarctation of the descending aortic arch",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00242",
    "question": "What is associated with Protoporphyria, erythropoietic, 2?",
    "seeds": [
      "Protoporphyria, erythropoietic, 2"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00243",
    "question": "What is associated with Abnormal skin morphology?",
    "seeds": [
      "Abnormal skin morphology"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00244",
    "question": "What is associated with Methylmalonic aciduria and homocystinuria, cblC type?",
    "seeds": [
      "Methylmalonic aciduria and homocystinuria, cblC type"
    ],
    "gold_answer": "Visceromegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00245",
    "question": "What is associated with Enlarged ovaries?",
    "seeds": [
      "Enlarged ovaries"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00246",
    "question": "What is associated with Central primitive neuroectodermal tumor?",
    "seeds": [
      "Central primitive neuroectodermal tumor"
    ],
    "gold_answer": "Neuroectodermal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00247",
    "question": "What is associated with Left atrial fibrosis?",
    "seeds": [
      "Left atrial fibrosis"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00248",
    "question": "What is associated with Platelet antibody positive?",
    "seeds": [
      "Platelet antibody positive"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00249",
    "question": "What is associated with Decreased circulating iron concentration?",
    "seeds": [
      "Decreased circulating iron concentration"
    ],
    "gold_answer": "Abnormal circulating iron concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00250",
    "question": "What is associated with Midshaft hypospadias?",
    "seeds": [
      "Midshaft hypospadias"
    ],
    "gold_answer": "Displacement of the urethral meatus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00251",
    "question": "What is associated with Right aortic arch with retroesophageal diverticulum of Kommerell?",
    "seeds": [
      "Right aortic arch with retroesophageal diverticulum of Kommerell"
    ],
    "gold_answer": "Right aortic arch",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00252",
    "question": "What is associated with Pressure ulcer?",
    "seeds": [
      "Pressure ulcer"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00253",
    "question": "What phenotype is associated with Hyperparathyroidism, primary, caused by water clear cell hyperplasia?",
    "seeds": [
      "Hyperparathyroidism, primary, caused by water clear cell hyperplasia"
    ],
    "gold_answer": "Primary hyperparathyroidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00254",
    "question": "What is associated with Anti-H3 antibody positivity?",
    "seeds": [
      "Anti-H3 antibody positivity"
    ],
    "gold_answer": "Anti-histone antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00255",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanges of the hand?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00256",
    "question": "What is associated with Diaphyseal dysplasia?",
    "seeds": [
      "Diaphyseal dysplasia"
    ],
    "gold_answer": "Skeletal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00257",
    "question": "What is associated with Absent dorsal skin creases over affected joints?",
    "seeds": [
      "Absent dorsal skin creases over affected joints"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00258",
    "question": "What is associated with Blood group B?",
    "seeds": [
      "Blood group B"
    ],
    "gold_answer": "ABO blood group",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00259",
    "question": "What is associated with Poor gross motor coordination?",
    "seeds": [
      "Poor gross motor coordination"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00260",
    "question": "What phenotype is associated with Preeclampsia?",
    "seeds": [
      "Preeclampsia"
    ],
    "gold_answer": "Headache",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00261",
    "question": "What is associated with Capillary hemangioma?",
    "seeds": [
      "Capillary hemangioma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00262",
    "question": "What is associated with Social anxiety?",
    "seeds": [
      "Social anxiety"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00263",
    "question": "What is associated with Decreased circulating complement factor B concentration?",
    "seeds": [
      "Decreased circulating complement factor B concentration"
    ],
    "gold_answer": "Abnormality of complement system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00264",
    "question": "What is associated with Aicardi-Goutieres syndrome 6?",
    "seeds": [
      "Aicardi-Goutieres syndrome 6"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00265",
    "question": "What is associated with Abnormality of amino acid metabolism?",
    "seeds": [
      "Abnormality of amino acid metabolism"
    ],
    "gold_answer": "Abnormal metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00266",
    "question": "What phenotype is associated with CYSTATHIONINURIA?",
    "seeds": [
      "CYSTATHIONINURIA"
    ],
    "gold_answer": "Cystathioninuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00267",
    "question": "What is associated with Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps?",
    "seeds": [
      "Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00268",
    "question": "What is associated with Autosomal recessive bestrophinopathy?",
    "seeds": [
      "Autosomal recessive bestrophinopathy"
    ],
    "gold_answer": "BEST1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00269",
    "question": "What is associated with Cutis marmorata?",
    "seeds": [
      "Cutis marmorata"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00270",
    "question": "What is associated with Paraseptal?",
    "seeds": [
      "Paraseptal"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00271",
    "question": "What is associated with Nasal hamartoma?",
    "seeds": [
      "Nasal hamartoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00272",
    "question": "What phenotype is associated with Undifferentiated pleomorphic sarcoma?",
    "seeds": [
      "Undifferentiated pleomorphic sarcoma"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00273",
    "question": "What is associated with Focal impaired awareness motor seizure with version?",
    "seeds": [
      "Focal impaired awareness motor seizure with version"
    ],
    "gold_answer": "Dialeptic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00274",
    "question": "What is associated with Thin vermilion border?",
    "seeds": [
      "Thin vermilion border"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00275",
    "question": "What is associated with Congenital lipoid adrenal hyperplasia due to STAR deficency?",
    "seeds": [
      "Congenital lipoid adrenal hyperplasia due to STAR deficency"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00276",
    "question": "What is associated with Raynaud phenomenon?",
    "seeds": [
      "Raynaud phenomenon"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00277",
    "question": "What is associated with Malar prominence?",
    "seeds": [
      "Malar prominence"
    ],
    "gold_answer": "Abnormal zygomatic bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00278",
    "question": "What is associated with Poliomyelitis?",
    "seeds": [
      "Poliomyelitis"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00279",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia, Handigodu type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, Handigodu type"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00280",
    "question": "What is associated with Triangular epiphysis of the middle phalanx of the 2nd toe?",
    "seeds": [
      "Triangular epiphysis of the middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Triangular epiphyses of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00281",
    "question": "What is associated with Cerebellar atrophy, developmental delay, and seizures?",
    "seeds": [
      "Cerebellar atrophy, developmental delay, and seizures"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00282",
    "question": "What is associated with Decreased cervical spine flexion due to contractures of posterior cervical muscles?",
    "seeds": [
      "Decreased cervical spine flexion due to contractures of posterior cervical muscles"
    ],
    "gold_answer": "Abnormal tendon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00283",
    "question": "What is associated with Cutis gyrata of scalp?",
    "seeds": [
      "Cutis gyrata of scalp"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00284",
    "question": "What is associated with Spinal muscular atrophy, Jokela type?",
    "seeds": [
      "Spinal muscular atrophy, Jokela type"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00285",
    "question": "What is associated with Subretinal exudate?",
    "seeds": [
      "Subretinal exudate"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00286",
    "question": "What is associated with Ring scotoma?",
    "seeds": [
      "Ring scotoma"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00287",
    "question": "What is associated with Chronic partially decreased circulating IgG1?",
    "seeds": [
      "Chronic partially decreased circulating IgG1"
    ],
    "gold_answer": "Decreased circulating IgG subclass concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00288",
    "question": "What is associated with Neoplasm?",
    "seeds": [
      "Neoplasm"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00289",
    "question": "What is associated with Increased complex N-glycan level?",
    "seeds": [
      "Increased complex N-glycan level"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00290",
    "question": "What is associated with Autosomal dominant otospondylomegaepiphyseal dysplasia?",
    "seeds": [
      "Autosomal dominant otospondylomegaepiphyseal dysplasia"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00291",
    "question": "What phenotype is associated with Vesicoureteral reflux 1?",
    "seeds": [
      "Vesicoureteral reflux 1"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00292",
    "question": "What phenotype is associated with Trichohepatoneurodevelopmental syndrome?",
    "seeds": [
      "Trichohepatoneurodevelopmental syndrome"
    ],
    "gold_answer": "Severely reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00293",
    "question": "What is associated with Total early-onset cataract?",
    "seeds": [
      "Total early-onset cataract"
    ],
    "gold_answer": "GJA8",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00294",
    "question": "What is associated with Absent proximal finger flexion creases?",
    "seeds": [
      "Absent proximal finger flexion creases"
    ],
    "gold_answer": "Abnormal finger flexion crease",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00295",
    "question": "What is associated with Harlequin phenomenon?",
    "seeds": [
      "Harlequin phenomenon"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00296",
    "question": "What is associated with MHC class I deficiency 3?",
    "seeds": [
      "MHC class I deficiency 3"
    ],
    "gold_answer": "Unusual virus reactivation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00297",
    "question": "What is associated with Nodular corneal dystrophy?",
    "seeds": [
      "Nodular corneal dystrophy"
    ],
    "gold_answer": "Opacification of the corneal stroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00298",
    "question": "What is associated with Alopecia, familial focal?",
    "seeds": [
      "Alopecia, familial focal"
    ],
    "gold_answer": "Abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00299",
    "question": "What is associated with Myopathy, congenital, compton-north?",
    "seeds": [
      "Myopathy, congenital, compton-north"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00300",
    "question": "What is associated with Cone-shaped epiphysis of the thumb?",
    "seeds": [
      "Cone-shaped epiphysis of the thumb"
    ],
    "gold_answer": "Abnormal hand epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00301",
    "question": "What is associated with Chiari type III malformation?",
    "seeds": [
      "Chiari type III malformation"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00302",
    "question": "What is associated with Parkinson disease 23, autosomal recessive early-onset?",
    "seeds": [
      "Parkinson disease 23, autosomal recessive early-onset"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00303",
    "question": "What is associated with Prostatic calculus?",
    "seeds": [
      "Prostatic calculus"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00304",
    "question": "What is associated with Reduced circulating cholinesterase activity?",
    "seeds": [
      "Reduced circulating cholinesterase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00305",
    "question": "What is associated with PFAPA syndrome?",
    "seeds": [
      "PFAPA syndrome"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00306",
    "question": "What is associated with Reduced muscle fiber delta sarcoglycan?",
    "seeds": [
      "Reduced muscle fiber delta sarcoglycan"
    ],
    "gold_answer": "Abnormal muscle fiber delta sarcoglycan",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00307",
    "question": "What is associated with Aorto-ventricular tunnel?",
    "seeds": [
      "Aorto-ventricular tunnel"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00308",
    "question": "What phenotype is associated with Fanconi anemia, complementation group F?",
    "seeds": [
      "Fanconi anemia, complementation group F"
    ],
    "gold_answer": "Hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00309",
    "question": "What phenotype is associated with Spermatogenic failure, X-linked, 6?",
    "seeds": [
      "Spermatogenic failure, X-linked, 6"
    ],
    "gold_answer": "Recurrent bronchitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00310",
    "question": "What is associated with Pain on the lateral aspect of the foot?",
    "seeds": [
      "Pain on the lateral aspect of the foot"
    ],
    "gold_answer": "Foot pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00311",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia, sponastrime type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, sponastrime type"
    ],
    "gold_answer": "Decreased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00312",
    "question": "What is associated with Multiple mitochondrial dysfunctions syndrome 4?",
    "seeds": [
      "Multiple mitochondrial dysfunctions syndrome 4"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00313",
    "question": "What is associated with Atrichia?",
    "seeds": [
      "Atrichia"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00314",
    "question": "What is associated with Cone-shaped epiphysis of the distal phalanx of the 2nd finger?",
    "seeds": [
      "Cone-shaped epiphysis of the distal phalanx of the 2nd finger"
    ],
    "gold_answer": "Cone-shaped epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00315",
    "question": "What is associated with Stickler syndrome, type II?",
    "seeds": [
      "Stickler syndrome, type II"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00316",
    "question": "What is associated with PLCG2-associated antibody deficiency and immune dysregulation?",
    "seeds": [
      "PLCG2-associated antibody deficiency and immune dysregulation"
    ],
    "gold_answer": "PLCG2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_test_00317",
    "question": "What is associated with EEG with generalized slow activity?",
    "seeds": [
      "EEG with generalized slow activity"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00318",
    "question": "What is associated with Lingual thyroid?",
    "seeds": [
      "Lingual thyroid"
    ],
    "gold_answer": "Abnormal thyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00319",
    "question": "What is associated with T2-hyperintense putaminal rim?",
    "seeds": [
      "T2-hyperintense putaminal rim"
    ],
    "gold_answer": "Abnormal corpus striatum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00320",
    "question": "What is associated with Anti-phosphatidyl inositol antibody positivity?",
    "seeds": [
      "Anti-phosphatidyl inositol antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00321",
    "question": "What is associated with Mirror image polydactyly?",
    "seeds": [
      "Mirror image polydactyly"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00322",
    "question": "What is associated with Abnormal erythrocyte adenosine triphosphate concentration?",
    "seeds": [
      "Abnormal erythrocyte adenosine triphosphate concentration"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00323",
    "question": "What is associated with EEG with frontal epileptiform discharges?",
    "seeds": [
      "EEG with frontal epileptiform discharges"
    ],
    "gold_answer": "EEG with focal epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00324",
    "question": "What is associated with Hypercapnia in cord blood?",
    "seeds": [
      "Hypercapnia in cord blood"
    ],
    "gold_answer": "Abnormal carbon dioxide level in cord blood",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00325",
    "question": "What is associated with Thyroid defect in oxidation and organification of iodide?",
    "seeds": [
      "Thyroid defect in oxidation and organification of iodide"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00326",
    "question": "What is associated with Myopathy with extrapyramidal signs?",
    "seeds": [
      "Myopathy with extrapyramidal signs"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00327",
    "question": "What is associated with Inappropriate antidiuretic hormone secretion?",
    "seeds": [
      "Inappropriate antidiuretic hormone secretion"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00328",
    "question": "What phenotype is associated with Idiopathic juvenile osteoporosis?",
    "seeds": [
      "Idiopathic juvenile osteoporosis"
    ],
    "gold_answer": "Vertebral compression fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00329",
    "question": "What is associated with Membranous choanal atresia?",
    "seeds": [
      "Membranous choanal atresia"
    ],
    "gold_answer": "Choanal atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00330",
    "question": "What is associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome?",
    "seeds": [
      "Megacystis-microcolon-intestinal hypoperistalsis syndrome"
    ],
    "gold_answer": "Abnormality of the amniotic fluid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00331",
    "question": "What is associated with Varicocele?",
    "seeds": [
      "Varicocele"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00332",
    "question": "What is associated with Cataract, posterior polar, 1 ctpa cataract, congenital total, included?",
    "seeds": [
      "Cataract, posterior polar, 1 ctpa cataract, congenital total, included"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00333",
    "question": "What is associated with Absent epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Absent epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00334",
    "question": "What is associated with Positive CSF treponema pallidum nucleic acid test?",
    "seeds": [
      "Positive CSF treponema pallidum nucleic acid test"
    ],
    "gold_answer": "Positive CSF infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00335",
    "question": "What is associated with Ankle clonus?",
    "seeds": [
      "Ankle clonus"
    ],
    "gold_answer": "Clonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00336",
    "question": "What is associated with Mitochondrial complex IV deficiency, nuclear type 18?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 18"
    ],
    "gold_answer": "Abnormal muscle tissue metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00337",
    "question": "What is associated with Enlarged mesenteric lymph node?",
    "seeds": [
      "Enlarged mesenteric lymph node"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00338",
    "question": "What is associated with Anemia, sideroblastic, 2, pyridoxine-refractory?",
    "seeds": [
      "Anemia, sideroblastic, 2, pyridoxine-refractory"
    ],
    "gold_answer": "Abnormal transferrin saturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00339",
    "question": "What phenotype is associated with GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-NEGATIVE?",
    "seeds": [
      "GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-NEGATIVE"
    ],
    "gold_answer": "Granulomatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00340",
    "question": "What is associated with Epistaxis, hereditary?",
    "seeds": [
      "Epistaxis, hereditary"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00341",
    "question": "What is associated with Late-onset spinocerebellar degeneration?",
    "seeds": [
      "Late-onset spinocerebellar degeneration"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00342",
    "question": "What is associated with Neurodevelopmental disorder with or without autism or seizures?",
    "seeds": [
      "Neurodevelopmental disorder with or without autism or seizures"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00343",
    "question": "What is associated with Protruding coccyx?",
    "seeds": [
      "Protruding coccyx"
    ],
    "gold_answer": "Abnormal coccyx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00344",
    "question": "What is associated with Dysmetric horizontal saccades?",
    "seeds": [
      "Dysmetric horizontal saccades"
    ],
    "gold_answer": "Dysmetric saccades",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00345",
    "question": "What is associated with Cone-shaped epiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Cone-shaped epiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00346",
    "question": "What phenotype is associated with Neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination"
    ],
    "gold_answer": "Cerebral palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00347",
    "question": "What is associated with Achondrogenesis, type IA?",
    "seeds": [
      "Achondrogenesis, type IA"
    ],
    "gold_answer": "Abnormality of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00348",
    "question": "What phenotype is associated with Multiple endocrine neoplasia, type IV?",
    "seeds": [
      "Multiple endocrine neoplasia, type IV"
    ],
    "gold_answer": "Renal angiomyolipoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00349",
    "question": "What is associated with Unilateral primary pulmonary dysgenesis?",
    "seeds": [
      "Unilateral primary pulmonary dysgenesis"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00350",
    "question": "What is associated with Ivory epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Ivory epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Sclerosis of middle phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00351",
    "question": "What phenotype is associated with T-SUBSTANCE ANOMALY?",
    "seeds": [
      "T-SUBSTANCE ANOMALY"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00352",
    "question": "What is associated with Maternal autoimmune disease?",
    "seeds": [
      "Maternal autoimmune disease"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00353",
    "question": "What is associated with Broncholith?",
    "seeds": [
      "Broncholith"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00354",
    "question": "What phenotype is associated with Pancreas, annular?",
    "seeds": [
      "Pancreas, annular"
    ],
    "gold_answer": "Annular pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00355",
    "question": "What is associated with Sclerosis of middle phalanx of toe?",
    "seeds": [
      "Sclerosis of middle phalanx of toe"
    ],
    "gold_answer": "Increased bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00356",
    "question": "What is associated with Abnormality of pattern reversal visual evoked potentials?",
    "seeds": [
      "Abnormality of pattern reversal visual evoked potentials"
    ],
    "gold_answer": "Abnormal brain-evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00357",
    "question": "What is associated with Abnormal lysosomal morphology?",
    "seeds": [
      "Abnormal lysosomal morphology"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00358",
    "question": "What is associated with Type II pneumocyte hyperplasia?",
    "seeds": [
      "Type II pneumocyte hyperplasia"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00359",
    "question": "What is associated with Renal hypoplasia?",
    "seeds": [
      "Renal hypoplasia"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00360",
    "question": "What is associated with Severely increased total eosinophil count?",
    "seeds": [
      "Severely increased total eosinophil count"
    ],
    "gold_answer": "Increased total eosinophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00361",
    "question": "What is associated with Charcot-Marie-Tooth disease, dominant intermediate G?",
    "seeds": [
      "Charcot-Marie-Tooth disease, dominant intermediate G"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00362",
    "question": "What is associated with Absent sebaceous glands?",
    "seeds": [
      "Absent sebaceous glands"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00363",
    "question": "What is associated with Huntington disease-like syndrome due to C9ORF72 expansions?",
    "seeds": [
      "Huntington disease-like syndrome due to C9ORF72 expansions"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00364",
    "question": "What is associated with Ocular pterygium-digital keloid dysplasia syndrome?",
    "seeds": [
      "Ocular pterygium-digital keloid dysplasia syndrome"
    ],
    "gold_answer": "Abnormal conjunctiva morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00365",
    "question": "What phenotype is associated with Erythema of acral regions?",
    "seeds": [
      "Erythema of acral regions"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00366",
    "question": "What is associated with Aicardi-Goutieres syndrome 9?",
    "seeds": [
      "Aicardi-Goutieres syndrome 9"
    ],
    "gold_answer": "Ectopic calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00367",
    "question": "What is associated with Hyperdeviation?",
    "seeds": [
      "Hyperdeviation"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00368",
    "question": "What is associated with Oculocerebrocutaneous syndrome?",
    "seeds": [
      "Oculocerebrocutaneous syndrome"
    ],
    "gold_answer": "Short phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00369",
    "question": "What is associated with Hypoplastic thumbnail?",
    "seeds": [
      "Hypoplastic thumbnail"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00370",
    "question": "What is associated with Abnormal lung lobation?",
    "seeds": [
      "Abnormal lung lobation"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00371",
    "question": "What phenotype is associated with Rubinstein-Taybi syndrome 1?",
    "seeds": [
      "Rubinstein-Taybi syndrome 1"
    ],
    "gold_answer": "Headache",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00372",
    "question": "What is associated with Brittle cornea syndrome 2?",
    "seeds": [
      "Brittle cornea syndrome 2"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00373",
    "question": "What is associated with Anti-folate receptor antibody positivity?",
    "seeds": [
      "Anti-folate receptor antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00374",
    "question": "What phenotype is associated with Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome?",
    "seeds": [
      "Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome"
    ],
    "gold_answer": "Abnormal aortic valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00375",
    "question": "What is associated with Generalized eruptive keratoacanthoma?",
    "seeds": [
      "Generalized eruptive keratoacanthoma"
    ],
    "gold_answer": "Keratitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00376",
    "question": "What is associated with Fifth metatarsal apophysitis?",
    "seeds": [
      "Fifth metatarsal apophysitis"
    ],
    "gold_answer": "Abnormal metatarsal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00377",
    "question": "What is associated with Hypophosphatemia?",
    "seeds": [
      "Hypophosphatemia"
    ],
    "gold_answer": "Abnormal blood phosphate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00378",
    "question": "What is associated with Abnormal anterior horn cell morphology?",
    "seeds": [
      "Abnormal anterior horn cell morphology"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00379",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 42?",
    "seeds": [
      "Ciliary dyskinesia, primary, 42"
    ],
    "gold_answer": "Reduced forced vital capacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00380",
    "question": "What is associated with Addictive opioid use?",
    "seeds": [
      "Addictive opioid use"
    ],
    "gold_answer": "Addictive substance use",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00381",
    "question": "What is associated with Waardenburg syndrome, type 4B?",
    "seeds": [
      "Waardenburg syndrome, type 4B"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00382",
    "question": "What is associated with Large joint predominance?",
    "seeds": [
      "Large joint predominance"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00383",
    "question": "What is associated with Hoarse voice?",
    "seeds": [
      "Hoarse voice"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00384",
    "question": "What is associated with Bone marrow maturation arrest?",
    "seeds": [
      "Bone marrow maturation arrest"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00385",
    "question": "What is associated with Abnormal shape of the palpebral fissure?",
    "seeds": [
      "Abnormal shape of the palpebral fissure"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00386",
    "question": "What is associated with Tubo-ovarian abscess?",
    "seeds": [
      "Tubo-ovarian abscess"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00387",
    "question": "What is associated with Foamy urine?",
    "seeds": [
      "Foamy urine"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00388",
    "question": "What phenotype is associated with Umbilical cord ulceration-intestinal atresia syndrome?",
    "seeds": [
      "Umbilical cord ulceration-intestinal atresia syndrome"
    ],
    "gold_answer": "Polyhydramnios",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00389",
    "question": "What phenotype is associated with Roberts-SC phocomelia syndrome?",
    "seeds": [
      "Roberts-SC phocomelia syndrome"
    ],
    "gold_answer": "Hyperplasia of the maxilla",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00390",
    "question": "What phenotype is associated with AHDC1-related intellectual disability-obstructive sleep apnea-mild dysmorphism syndrome?",
    "seeds": [
      "AHDC1-related intellectual disability-obstructive sleep apnea-mild dysmorphism syndrome"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00391",
    "question": "What is associated with EEG with changes in voltage?",
    "seeds": [
      "EEG with changes in voltage"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00392",
    "question": "What is associated with Short stature, oligodontia, dysmorphic facies, and motor delay?",
    "seeds": [
      "Short stature, oligodontia, dysmorphic facies, and motor delay"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the optic nerve",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00393",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 45?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 45"
    ],
    "gold_answer": "Short chin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00394",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 14?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 14"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00395",
    "question": "What is associated with Cockayne syndrome type 3?",
    "seeds": [
      "Cockayne syndrome type 3"
    ],
    "gold_answer": "Functional abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00396",
    "question": "What phenotype is associated with Scimitar syndrome?",
    "seeds": [
      "Scimitar syndrome"
    ],
    "gold_answer": "Single ventricle",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00397",
    "question": "What is associated with Sleep-related eating behavior?",
    "seeds": [
      "Sleep-related eating behavior"
    ],
    "gold_answer": "Abnormal eating behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00398",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 16?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 16"
    ],
    "gold_answer": "Synophrys",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00399",
    "question": "What phenotype is associated with Surfactant metabolism dysfunction, pulmonary, 4?",
    "seeds": [
      "Surfactant metabolism dysfunction, pulmonary, 4"
    ],
    "gold_answer": "Restrictive ventilatory defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00400",
    "question": "What phenotype is associated with Acyl-Coa dehydrogenase, medium-chain, deficiency of?",
    "seeds": [
      "Acyl-Coa dehydrogenase, medium-chain, deficiency of"
    ],
    "gold_answer": "Lethargy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00401",
    "question": "What is associated with Glycogen storage disease due to glycogen branching enzyme deficiency, congenital neuromuscular form?",
    "seeds": [
      "Glycogen storage disease due to glycogen branching enzyme deficiency, congenital neuromuscular form"
    ],
    "gold_answer": "GBE1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00402",
    "question": "What is associated with Anagen effluvium?",
    "seeds": [
      "Anagen effluvium"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00403",
    "question": "What is associated with Increased fucosylation of N-linked protein glycosylation?",
    "seeds": [
      "Increased fucosylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein N-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00404",
    "question": "What is associated with Diminishment of social interactions?",
    "seeds": [
      "Diminishment of social interactions"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00405",
    "question": "What is associated with Nyctalopia?",
    "seeds": [
      "Nyctalopia"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00406",
    "question": "What is associated with Airway chondritis?",
    "seeds": [
      "Airway chondritis"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00407",
    "question": "What is associated with Renal arteriole intima/media arteriolosclerosis?",
    "seeds": [
      "Renal arteriole intima/media arteriolosclerosis"
    ],
    "gold_answer": "Abnormal renal arteriole intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00408",
    "question": "What is associated with Lipedema?",
    "seeds": [
      "Lipedema"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00409",
    "question": "What is associated with Persistent repetition of sounds?",
    "seeds": [
      "Persistent repetition of sounds"
    ],
    "gold_answer": "Abnormal cognitive process",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00410",
    "question": "What phenotype is associated with Unilateral polymicrogyria?",
    "seeds": [
      "Unilateral polymicrogyria"
    ],
    "gold_answer": "Appendicular hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00411",
    "question": "What is associated with Decreased specific antibody response to vaccination?",
    "seeds": [
      "Decreased specific antibody response to vaccination"
    ],
    "gold_answer": "Decreased circulating level of specific antibody",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00412",
    "question": "What phenotype is associated with Oocyte/zygote/embryo maturation arrest 14?",
    "seeds": [
      "Oocyte/zygote/embryo maturation arrest 14"
    ],
    "gold_answer": "Oocyte maturation arrest",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00413",
    "question": "What is associated with Abnormal HDL cholesterol concentration?",
    "seeds": [
      "Abnormal HDL cholesterol concentration"
    ],
    "gold_answer": "Abnormal circulating cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00414",
    "question": "What is associated with Decreased monosialylated core 1 O-glycan level?",
    "seeds": [
      "Decreased monosialylated core 1 O-glycan level"
    ],
    "gold_answer": "Abnormal protein O-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00415",
    "question": "What is associated with Autosomal recessive chorioretinopathy-microcephaly syndrome?",
    "seeds": [
      "Autosomal recessive chorioretinopathy-microcephaly syndrome"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00416",
    "question": "What is associated with 3-hydroxydicarboxylic aciduria?",
    "seeds": [
      "3-hydroxydicarboxylic aciduria"
    ],
    "gold_answer": "Organic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00417",
    "question": "What is associated with Bleeding disorder due to P2Y12 defect?",
    "seeds": [
      "Bleeding disorder due to P2Y12 defect"
    ],
    "gold_answer": "P2RY12",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00418",
    "question": "What is associated with Incomplete right bundle branch block?",
    "seeds": [
      "Incomplete right bundle branch block"
    ],
    "gold_answer": "Cardiac conduction abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00419",
    "question": "What is associated with Increased circulating carnosine concentration?",
    "seeds": [
      "Increased circulating carnosine concentration"
    ],
    "gold_answer": "Abnormal circulating carnosine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00420",
    "question": "What is associated with Cerebellar dentate nucleus calcification?",
    "seeds": [
      "Cerebellar dentate nucleus calcification"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00421",
    "question": "What is associated with Abnormal circulating albumin concentration?",
    "seeds": [
      "Abnormal circulating albumin concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00422",
    "question": "What is associated with Pycnodysostosis?",
    "seeds": [
      "Pycnodysostosis"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00423",
    "question": "What is associated with Increased circulating very long-chain fatty acid concentration?",
    "seeds": [
      "Increased circulating very long-chain fatty acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00424",
    "question": "What is associated with Anejaculation?",
    "seeds": [
      "Anejaculation"
    ],
    "gold_answer": "Abnormal male reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00425",
    "question": "What is associated with Bicuspid aortic valve with right-noncoronary cusp fusion?",
    "seeds": [
      "Bicuspid aortic valve with right-noncoronary cusp fusion"
    ],
    "gold_answer": "Bicuspid aortic valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00426",
    "question": "What is associated with Compressed lymph-node sinuses?",
    "seeds": [
      "Compressed lymph-node sinuses"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00427",
    "question": "What is associated with Familial atrial myxoma?",
    "seeds": [
      "Familial atrial myxoma"
    ],
    "gold_answer": "Neoplasm of the heart",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00428",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 25?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 25"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00429",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 49?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 49"
    ],
    "gold_answer": "Abnormal activity of mitochondrial respiratory chain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00430",
    "question": "What is associated with Retinopathy of prematurity?",
    "seeds": [
      "Retinopathy of prematurity"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00431",
    "question": "What is associated with Microcephaly-seizures-intellectual disability-heart disease syndrome?",
    "seeds": [
      "Microcephaly-seizures-intellectual disability-heart disease syndrome"
    ],
    "gold_answer": "Polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00432",
    "question": "What phenotype is associated with Congenital prothrombin deficiency?",
    "seeds": [
      "Congenital prothrombin deficiency"
    ],
    "gold_answer": "Bruising susceptibility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00433",
    "question": "What is associated with Truncal ataxia?",
    "seeds": [
      "Truncal ataxia"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00434",
    "question": "What is associated with Obsessive-compulsive trait?",
    "seeds": [
      "Obsessive-compulsive trait"
    ],
    "gold_answer": "Compulsive behaviors",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00435",
    "question": "What is associated with Hyperprolactinemia?",
    "seeds": [
      "Hyperprolactinemia"
    ],
    "gold_answer": "Abnormality of the menstrual cycle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00436",
    "question": "What is associated with Epilepsy, progressive myoclonic, 6?",
    "seeds": [
      "Epilepsy, progressive myoclonic, 6"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00437",
    "question": "What is associated with Tubulointerstitial fibrosis?",
    "seeds": [
      "Tubulointerstitial fibrosis"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00438",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 3?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 3"
    ],
    "gold_answer": "Abnormality of refraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00439",
    "question": "What is associated with Hemangiopericytoma, malignant?",
    "seeds": [
      "Hemangiopericytoma, malignant"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00440",
    "question": "What is associated with Eyelid laxity?",
    "seeds": [
      "Eyelid laxity"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00441",
    "question": "What is associated with EEG with generalized epileptiform discharges?",
    "seeds": [
      "EEG with generalized epileptiform discharges"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00442",
    "question": "What is associated with Abnormal tricuspid valve physiology?",
    "seeds": [
      "Abnormal tricuspid valve physiology"
    ],
    "gold_answer": "Abnormal atrioventricular valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00443",
    "question": "What is associated with Abnormal naive B cell proportion?",
    "seeds": [
      "Abnormal naive B cell proportion"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00444",
    "question": "What phenotype is associated with Autosomal dominant polycystic kidney disease?",
    "seeds": [
      "Autosomal dominant polycystic kidney disease"
    ],
    "gold_answer": "Social and occupational deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00445",
    "question": "What phenotype is associated with Neurodevelopmental disorder with seizures and joint laxity?",
    "seeds": [
      "Neurodevelopmental disorder with seizures and joint laxity"
    ],
    "gold_answer": "Abnormal pulmonary valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00446",
    "question": "What is associated with Hip external rotation contracture?",
    "seeds": [
      "Hip external rotation contracture"
    ],
    "gold_answer": "Limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00447",
    "question": "What phenotype is associated with Carabelli anomaly of maxillary molar teeth?",
    "seeds": [
      "Carabelli anomaly of maxillary molar teeth"
    ],
    "gold_answer": "Abnormality of molar",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00448",
    "question": "What is associated with Oligohydramnios?",
    "seeds": [
      "Oligohydramnios"
    ],
    "gold_answer": "Abnormality of the amniotic fluid",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00449",
    "question": "What is associated with Reduced muscle 6-phosphofructokinase activity?",
    "seeds": [
      "Reduced muscle 6-phosphofructokinase activity"
    ],
    "gold_answer": "Abnormal enzyme activity in muscle tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00450",
    "question": "What is associated with Glial remnants anterior to the optic disc?",
    "seeds": [
      "Glial remnants anterior to the optic disc"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00451",
    "question": "What is associated with Abnormal ankle morphology?",
    "seeds": [
      "Abnormal ankle morphology"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00452",
    "question": "What is associated with Enlarged epiphyses?",
    "seeds": [
      "Enlarged epiphyses"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00453",
    "question": "What is associated with RHINY?",
    "seeds": [
      "RHINY"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00454",
    "question": "What is associated with Decreased neutrophil toll-like receptor signalling?",
    "seeds": [
      "Decreased neutrophil toll-like receptor signalling"
    ],
    "gold_answer": "Abnormal leukocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00455",
    "question": "What is associated with Pancreatic intraductal papillary mucinous neoplasm?",
    "seeds": [
      "Pancreatic intraductal papillary mucinous neoplasm"
    ],
    "gold_answer": "Neoplasm of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00456",
    "question": "What phenotype is associated with Pseudohypoaldosteronism, type IB2, autosomal recessive?",
    "seeds": [
      "Pseudohypoaldosteronism, type IB2, autosomal recessive"
    ],
    "gold_answer": "Dehydration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00457",
    "question": "What is associated with Fetal methylmercury syndrome?",
    "seeds": [
      "Fetal methylmercury syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00458",
    "question": "What is associated with Intralobar nephroblastomatosis?",
    "seeds": [
      "Intralobar nephroblastomatosis"
    ],
    "gold_answer": "Embryonal renal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00459",
    "question": "What is associated with Bartter syndrome?",
    "seeds": [
      "Bartter syndrome"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00460",
    "question": "What is associated with Unaided visual acuity 0.2 LogMAR?",
    "seeds": [
      "Unaided visual acuity 0.2 LogMAR"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00461",
    "question": "What is associated with Amyotrophic lateral sclerosis type 4?",
    "seeds": [
      "Amyotrophic lateral sclerosis type 4"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00462",
    "question": "What is associated with Arginine vasopressin resistance-intracranial calcification-short stature-facial dysmorphism syndrome?",
    "seeds": [
      "Arginine vasopressin resistance-intracranial calcification-short stature-facial dysmorphism syndrome"
    ],
    "gold_answer": "Ectopic calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00463",
    "question": "What phenotype is associated with Gillessen-Kaesbach-Nishimura syndrome?",
    "seeds": [
      "Gillessen-Kaesbach-Nishimura syndrome"
    ],
    "gold_answer": "Omphalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00464",
    "question": "What is associated with Agenesis of molar?",
    "seeds": [
      "Agenesis of molar"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00465",
    "question": "What is associated with Nabais Sa-de Vries syndrome, type 1?",
    "seeds": [
      "Nabais Sa-de Vries syndrome, type 1"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00466",
    "question": "What is associated with Tongue atrophy?",
    "seeds": [
      "Tongue atrophy"
    ],
    "gold_answer": "Abnormality of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00467",
    "question": "What is associated with Branchiooculofacial syndrome?",
    "seeds": [
      "Branchiooculofacial syndrome"
    ],
    "gold_answer": "Abnormal ureter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00468",
    "question": "What is associated with Scapular exostoses?",
    "seeds": [
      "Scapular exostoses"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00469",
    "question": "What is associated with Fragmented metacarpal epiphysis?",
    "seeds": [
      "Fragmented metacarpal epiphysis"
    ],
    "gold_answer": "Fragmented upper limb epiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00470",
    "question": "What is associated with Complete duplication of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Complete duplication of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Duplication of the phalanges of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00471",
    "question": "What is associated with Sclerosis of middle phalanx of finger?",
    "seeds": [
      "Sclerosis of middle phalanx of finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00472",
    "question": "What is associated with Abnormal circulating biopterin concentration?",
    "seeds": [
      "Abnormal circulating biopterin concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00473",
    "question": "What is associated with Immunodeficiency 70?",
    "seeds": [
      "Immunodeficiency 70"
    ],
    "gold_answer": "Decreased circulating IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00474",
    "question": "What is associated with Inflammatory bowel disease 3?",
    "seeds": [
      "Inflammatory bowel disease 3"
    ],
    "gold_answer": "Colitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00475",
    "question": "What is associated with Reduced forced vital capacity?",
    "seeds": [
      "Reduced forced vital capacity"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00476",
    "question": "What is associated with Undermodelled hand bones?",
    "seeds": [
      "Undermodelled hand bones"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00477",
    "question": "What is associated with Microform holoprosencephaly?",
    "seeds": [
      "Microform holoprosencephaly"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00478",
    "question": "What is associated with Giant somatosensory evoked potentials?",
    "seeds": [
      "Giant somatosensory evoked potentials"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00479",
    "question": "What is associated with Elevated urinary 3-hydroxyisobutyric acid level?",
    "seeds": [
      "Elevated urinary 3-hydroxyisobutyric acid level"
    ],
    "gold_answer": "Abnormal urine carboxylic acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00480",
    "question": "What is associated with Bent long bone?",
    "seeds": [
      "Bent long bone"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00481",
    "question": "What is associated with Superficial epidermolytic ichthyosis?",
    "seeds": [
      "Superficial epidermolytic ichthyosis"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00482",
    "question": "What is associated with Intellectual developmental disorder, X-linked 103?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 103"
    ],
    "gold_answer": "Abnormal lateral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00483",
    "question": "What is associated with Albinism, oculocutaneous, type V?",
    "seeds": [
      "Albinism, oculocutaneous, type V"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00484",
    "question": "What is associated with Craniometaphyseal dysplasia, autosomal recessive?",
    "seeds": [
      "Craniometaphyseal dysplasia, autosomal recessive"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00485",
    "question": "What is associated with Complex febrile seizure?",
    "seeds": [
      "Complex febrile seizure"
    ],
    "gold_answer": "Seizure precipitated by febrile infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00486",
    "question": "What is associated with Glomerular parietal epithelial cell hypertrophy?",
    "seeds": [
      "Glomerular parietal epithelial cell hypertrophy"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00487",
    "question": "What is associated with Gastric intraepithelial lymphocytosis?",
    "seeds": [
      "Gastric intraepithelial lymphocytosis"
    ],
    "gold_answer": "Abnormal stomach morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00488",
    "question": "What is associated with Abnormal coronary artery origin?",
    "seeds": [
      "Abnormal coronary artery origin"
    ],
    "gold_answer": "Abnormal coronary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00489",
    "question": "What is associated with Renal artery aneurysm?",
    "seeds": [
      "Renal artery aneurysm"
    ],
    "gold_answer": "Abnormal renal artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00490",
    "question": "What is associated with Melasma?",
    "seeds": [
      "Melasma"
    ],
    "gold_answer": "Hyperpigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00491",
    "question": "What is associated with Thickened helices?",
    "seeds": [
      "Thickened helices"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00492",
    "question": "What is associated with Atlantoaxial abnormality?",
    "seeds": [
      "Atlantoaxial abnormality"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00493",
    "question": "What is associated with Shortened sleep phase?",
    "seeds": [
      "Shortened sleep phase"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00494",
    "question": "What is associated with Focal?",
    "seeds": [
      "Focal"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00495",
    "question": "What is associated with Atrial septal defect?",
    "seeds": [
      "Atrial septal defect"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00496",
    "question": "What is associated with Abnormal finger phalanx morphology?",
    "seeds": [
      "Abnormal finger phalanx morphology"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00497",
    "question": "What phenotype is associated with Hydatidiform mole, recurrent, 1?",
    "seeds": [
      "Hydatidiform mole, recurrent, 1"
    ],
    "gold_answer": "Menometrorrhagia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00498",
    "question": "What is associated with Macrovesicular hepatic steatosis?",
    "seeds": [
      "Macrovesicular hepatic steatosis"
    ],
    "gold_answer": "Hepatic steatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00499",
    "question": "What is associated with Glutaric acidemia type 3?",
    "seeds": [
      "Glutaric acidemia type 3"
    ],
    "gold_answer": "Abnormal diminished volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00500",
    "question": "What is associated with Adult-onset night blindness?",
    "seeds": [
      "Adult-onset night blindness"
    ],
    "gold_answer": "Nyctalopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00501",
    "question": "What phenotype is associated with Muscular dystrophy, limb-girdle, type 2Q?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, type 2Q"
    ],
    "gold_answer": "Proximal muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00502",
    "question": "What is associated with Very frequent?",
    "seeds": [
      "Very frequent"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00503",
    "question": "What is associated with Aplasia of the olfactory tract?",
    "seeds": [
      "Aplasia of the olfactory tract"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00504",
    "question": "What phenotype is associated with Cardiomyopathy, dilated, 1Y?",
    "seeds": [
      "Cardiomyopathy, dilated, 1Y"
    ],
    "gold_answer": "Atrial fibrillation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00505",
    "question": "What is associated with Autoinflammatory disease, multisystem, with immune dysregulation, X-linked?",
    "seeds": [
      "Autoinflammatory disease, multisystem, with immune dysregulation, X-linked"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00506",
    "question": "What is associated with Spinal muscular atrophy, type IV?",
    "seeds": [
      "Spinal muscular atrophy, type IV"
    ],
    "gold_answer": "Motor neuron atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00507",
    "question": "What is associated with Double aortic arch?",
    "seeds": [
      "Double aortic arch"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00508",
    "question": "What is associated with Induced vaginal delivery?",
    "seeds": [
      "Induced vaginal delivery"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00509",
    "question": "What is associated with Thyroid hormone metabolism, abnormal?",
    "seeds": [
      "Thyroid hormone metabolism, abnormal"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00510",
    "question": "What is associated with Gout susceptibility 4?",
    "seeds": [
      "Gout susceptibility 4"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00511",
    "question": "What is associated with Sclerosis of the distal phalanx of the thumb?",
    "seeds": [
      "Sclerosis of the distal phalanx of the thumb"
    ],
    "gold_answer": "Sclerosis of finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00512",
    "question": "What is associated with Abnormal T3/T4 ratio?",
    "seeds": [
      "Abnormal T3/T4 ratio"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00513",
    "question": "What is associated with Fibrous tissue neoplasm?",
    "seeds": [
      "Fibrous tissue neoplasm"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00514",
    "question": "What is associated with Aplasia of the olfactory bulb?",
    "seeds": [
      "Aplasia of the olfactory bulb"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00515",
    "question": "What is associated with Enlarged epiphysis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Enlarged epiphysis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal fifth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00516",
    "question": "What phenotype is associated with Diamond-Blackfan anemia 15 with mandibulofacial dysostosis?",
    "seeds": [
      "Diamond-Blackfan anemia 15 with mandibulofacial dysostosis"
    ],
    "gold_answer": "Mixed hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00517",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 15?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 15"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00518",
    "question": "What is associated with Abnormal brain choline level by MRS?",
    "seeds": [
      "Abnormal brain choline level by MRS"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00519",
    "question": "What is associated with Short esophagus?",
    "seeds": [
      "Short esophagus"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00520",
    "question": "What is associated with Reduced ability to form peer relationships?",
    "seeds": [
      "Reduced ability to form peer relationships"
    ],
    "gold_answer": "Abnormal social development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00521",
    "question": "What is associated with Megarectum?",
    "seeds": [
      "Megarectum"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00522",
    "question": "What is associated with Frequent napping?",
    "seeds": [
      "Frequent napping"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00523",
    "question": "What phenotype is associated with Retinopathy of prematurity stage 5b?",
    "seeds": [
      "Retinopathy of prematurity stage 5b"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00524",
    "question": "What is associated with Temporomandibular joint adhesion?",
    "seeds": [
      "Temporomandibular joint adhesion"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00525",
    "question": "What is associated with Bronchial isomerism?",
    "seeds": [
      "Bronchial isomerism"
    ],
    "gold_answer": "Isomerism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00526",
    "question": "What is associated with Aplasia/Hypoplasia of the calvaria?",
    "seeds": [
      "Aplasia/Hypoplasia of the calvaria"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00527",
    "question": "What is associated with Muscle fiber cytoplasmatic inclusion bodies?",
    "seeds": [
      "Muscle fiber cytoplasmatic inclusion bodies"
    ],
    "gold_answer": "Pathological inclusion body",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00528",
    "question": "What phenotype is associated with Isolated splenogonadal fusion?",
    "seeds": [
      "Isolated splenogonadal fusion"
    ],
    "gold_answer": "Inguinal hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00529",
    "question": "What phenotype is associated with Porencephaly?",
    "seeds": [
      "Porencephaly"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00530",
    "question": "What is associated with Aortic smooth muscle cell nuclei loss?",
    "seeds": [
      "Aortic smooth muscle cell nuclei loss"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00531",
    "question": "What phenotype is associated with Spinocerebellar ataxia 4?",
    "seeds": [
      "Spinocerebellar ataxia 4"
    ],
    "gold_answer": "Babinski sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00532",
    "question": "What is associated with Heterophoria?",
    "seeds": [
      "Heterophoria"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00533",
    "question": "What is associated with Abnormal clitoris morphology?",
    "seeds": [
      "Abnormal clitoris morphology"
    ],
    "gold_answer": "Abnormal female external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00534",
    "question": "What phenotype is associated with Combined malonic and methylmalonic aciduria?",
    "seeds": [
      "Combined malonic and methylmalonic aciduria"
    ],
    "gold_answer": "Failure to thrive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00535",
    "question": "What is associated with Postural hypotension with compensatory tachycardia?",
    "seeds": [
      "Postural hypotension with compensatory tachycardia"
    ],
    "gold_answer": "Orthostatic hypotension",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00536",
    "question": "What phenotype is associated with Osteochondrodysplasia, complex lethal, Symoens-Barnes-Gistelinck type?",
    "seeds": [
      "Osteochondrodysplasia, complex lethal, Symoens-Barnes-Gistelinck type"
    ],
    "gold_answer": "Severe infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00537",
    "question": "What is associated with Exposure to humid conditions?",
    "seeds": [
      "Exposure to humid conditions"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00538",
    "question": "What is associated with Absent ossification of capital femoral epiphysis?",
    "seeds": [
      "Absent ossification of capital femoral epiphysis"
    ],
    "gold_answer": "Abnormal femoral neck/head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00539",
    "question": "What is associated with Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1?",
    "seeds": [
      "Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00540",
    "question": "What is associated with Renal neoplasm?",
    "seeds": [
      "Renal neoplasm"
    ],
    "gold_answer": "Abnormality of the urinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00541",
    "question": "What phenotype is associated with Ichthyosis, split hairs, and amino aciduria?",
    "seeds": [
      "Ichthyosis, split hairs, and amino aciduria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00542",
    "question": "What is associated with Subcortical white matter calcifications?",
    "seeds": [
      "Subcortical white matter calcifications"
    ],
    "gold_answer": "Intracranial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00543",
    "question": "What is associated with Perifollicular hyperkeratosis?",
    "seeds": [
      "Perifollicular hyperkeratosis"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00544",
    "question": "What phenotype is associated with GJC2-related late-onset primary lymphedema?",
    "seeds": [
      "GJC2-related late-onset primary lymphedema"
    ],
    "gold_answer": "Ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00545",
    "question": "What is associated with Decreased mean corpuscular volume?",
    "seeds": [
      "Decreased mean corpuscular volume"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00546",
    "question": "What is associated with Non-medullary thyroid carcinoma?",
    "seeds": [
      "Non-medullary thyroid carcinoma"
    ],
    "gold_answer": "Thyroid carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00547",
    "question": "What is associated with Decreased circulating superoxide dismutase concentration?",
    "seeds": [
      "Decreased circulating superoxide dismutase concentration"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00548",
    "question": "What phenotype is associated with Corneal dystrophy, fuchs endothelial, 6?",
    "seeds": [
      "Corneal dystrophy, fuchs endothelial, 6"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00549",
    "question": "What is associated with Copper accumulation in liver?",
    "seeds": [
      "Copper accumulation in liver"
    ],
    "gold_answer": "Abnormal liver metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00550",
    "question": "What is associated with Abnormal circulating neopterin concentration?",
    "seeds": [
      "Abnormal circulating neopterin concentration"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00551",
    "question": "What is associated with Anal margin basal cell carcinoma?",
    "seeds": [
      "Anal margin basal cell carcinoma"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00552",
    "question": "What is associated with Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant?",
    "seeds": [
      "Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant"
    ],
    "gold_answer": "Abnormality of skin adnexa physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00553",
    "question": "What is associated with Autosomal recessive nail dysplasia?",
    "seeds": [
      "Autosomal recessive nail dysplasia"
    ],
    "gold_answer": "FZD6",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00554",
    "question": "What phenotype is associated with Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II?",
    "seeds": [
      "Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II"
    ],
    "gold_answer": "Recurrent Staphylococcus aureus infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00555",
    "question": "What is associated with Abnormal muscle fiber myotilin?",
    "seeds": [
      "Abnormal muscle fiber myotilin"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00556",
    "question": "What is associated with Unusual virus reactivation?",
    "seeds": [
      "Unusual virus reactivation"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00557",
    "question": "What is associated with Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia?",
    "seeds": [
      "Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia"
    ],
    "gold_answer": "GLE1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00558",
    "question": "What is associated with Bickerstaff brainstem encephalitis?",
    "seeds": [
      "Bickerstaff brainstem encephalitis"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00559",
    "question": "What phenotype is associated with Periventricular nodular heterotopia?",
    "seeds": [
      "Periventricular nodular heterotopia"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00560",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 29?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 29"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00561",
    "question": "What is associated with Bullet-shaped 2nd toe phalanx?",
    "seeds": [
      "Bullet-shaped 2nd toe phalanx"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00562",
    "question": "What is associated with Abnormal liver enzyme activity or concentration?",
    "seeds": [
      "Abnormal liver enzyme activity or concentration"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00563",
    "question": "What is associated with Spasticity?",
    "seeds": [
      "Spasticity"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00564",
    "question": "What is associated with Fanconi anemia, complementation group J?",
    "seeds": [
      "Fanconi anemia, complementation group J"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00565",
    "question": "What is associated with Esophageal cancer, somatic?",
    "seeds": [
      "Esophageal cancer, somatic"
    ],
    "gold_answer": "Abnormal esophagus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00566",
    "question": "What phenotype is associated with Isolated absence/hypoplasia of fingers excluding thumb, unilateral?",
    "seeds": [
      "Isolated absence/hypoplasia of fingers excluding thumb, unilateral"
    ],
    "gold_answer": "Short metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00567",
    "question": "What phenotype is associated with Parotidomegaly, hereditary bilateral?",
    "seeds": [
      "Parotidomegaly, hereditary bilateral"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00568",
    "question": "What is associated with Cono-spondylar dysplasia?",
    "seeds": [
      "Cono-spondylar dysplasia"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00569",
    "question": "What is associated with ADan amyloidosis?",
    "seeds": [
      "ADan amyloidosis"
    ],
    "gold_answer": "ITM2B",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00570",
    "question": "What is associated with Nephronophthisis 14?",
    "seeds": [
      "Nephronophthisis 14"
    ],
    "gold_answer": "CFAP53",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00571",
    "question": "What is associated with Isothenuria?",
    "seeds": [
      "Isothenuria"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00572",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 6 (Dravet syndrome)?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 6 (Dravet syndrome)"
    ],
    "gold_answer": "Myopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00573",
    "question": "What is associated with Restrictive cardiomyopathy?",
    "seeds": [
      "Restrictive cardiomyopathy"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00574",
    "question": "What is associated with Abnormal odontoid tissue morphology?",
    "seeds": [
      "Abnormal odontoid tissue morphology"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00575",
    "question": "What is associated with Hallucinations?",
    "seeds": [
      "Hallucinations"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00576",
    "question": "What is associated with Chronic granulomatous disease 5, autosomal recessive?",
    "seeds": [
      "Chronic granulomatous disease 5, autosomal recessive"
    ],
    "gold_answer": "Unusual fungal infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00577",
    "question": "What is associated with Progressive extrapyramidal movement disorder?",
    "seeds": [
      "Progressive extrapyramidal movement disorder"
    ],
    "gold_answer": "Abnormality of extrapyramidal motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00578",
    "question": "What is associated with Juxtafoveal choroidal neovascularization?",
    "seeds": [
      "Juxtafoveal choroidal neovascularization"
    ],
    "gold_answer": "Choroidal neovascularization",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00579",
    "question": "What is associated with Microphthalmia, syndromic 1?",
    "seeds": [
      "Microphthalmia, syndromic 1"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00580",
    "question": "What is associated with Sabinas brittle hair syndrome?",
    "seeds": [
      "Sabinas brittle hair syndrome"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00581",
    "question": "What is associated with Hip flexion contracture?",
    "seeds": [
      "Hip flexion contracture"
    ],
    "gold_answer": "Hip contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00582",
    "question": "What is associated with Spatulate thumbs?",
    "seeds": [
      "Spatulate thumbs"
    ],
    "gold_answer": "Broad phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00583",
    "question": "What is associated with Melnick-Needles syndrome?",
    "seeds": [
      "Melnick-Needles syndrome"
    ],
    "gold_answer": "Abnormal tibia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00584",
    "question": "What is associated with Cleft mandible?",
    "seeds": [
      "Cleft mandible"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00585",
    "question": "What is associated with Neoplasm of the ceruminal gland?",
    "seeds": [
      "Neoplasm of the ceruminal gland"
    ],
    "gold_answer": "Neoplasm of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00586",
    "question": "What phenotype is associated with Regional odontodysplasia?",
    "seeds": [
      "Regional odontodysplasia"
    ],
    "gold_answer": "Blue sclerae",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00587",
    "question": "What is associated with Bracket epiphysis of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Bracket epiphysis of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Bracket epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00588",
    "question": "What is associated with Type II lissencephaly?",
    "seeds": [
      "Type II lissencephaly"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00589",
    "question": "What is associated with Follicular bronchiolitis?",
    "seeds": [
      "Follicular bronchiolitis"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00590",
    "question": "What is associated with 12q14 microdeletion syndrome?",
    "seeds": [
      "12q14 microdeletion syndrome"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00591",
    "question": "What is associated with Biliary cirrhosis, primary?",
    "seeds": [
      "Biliary cirrhosis, primary"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00592",
    "question": "What is associated with Elevated circulating alpha-fetoprotein concentration?",
    "seeds": [
      "Elevated circulating alpha-fetoprotein concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00593",
    "question": "What phenotype is associated with Lissencephaly 7 with cerebellar hypoplasia?",
    "seeds": [
      "Lissencephaly 7 with cerebellar hypoplasia"
    ],
    "gold_answer": "Persistent head lag",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00594",
    "question": "What phenotype is associated with Cirrhosis, familial?",
    "seeds": [
      "Cirrhosis, familial"
    ],
    "gold_answer": "Cirrhosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00595",
    "question": "What is associated with Exacerbated by aspirin exposure?",
    "seeds": [
      "Exacerbated by aspirin exposure"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00596",
    "question": "What is associated with Marshall syndrome?",
    "seeds": [
      "Marshall syndrome"
    ],
    "gold_answer": "Broad phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00597",
    "question": "What is associated with Impaired myocardial contractility?",
    "seeds": [
      "Impaired myocardial contractility"
    ],
    "gold_answer": "Reduced systolic function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00598",
    "question": "What is associated with Punctate keratitis?",
    "seeds": [
      "Punctate keratitis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00599",
    "question": "What is associated with Abnormality of the epiphysis of the 2nd metacarpal?",
    "seeds": [
      "Abnormality of the epiphysis of the 2nd metacarpal"
    ],
    "gold_answer": "Abnormal 2nd metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00600",
    "question": "What is associated with Atretic vas deferens?",
    "seeds": [
      "Atretic vas deferens"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00601",
    "question": "What is associated with Abnormal distal humeral epiphysis morphology?",
    "seeds": [
      "Abnormal distal humeral epiphysis morphology"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00602",
    "question": "What is associated with Abnormal anteroposterior retina thickness on OCT?",
    "seeds": [
      "Abnormal anteroposterior retina thickness on OCT"
    ],
    "gold_answer": "Abnormal posterior segment imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00603",
    "question": "What is associated with Mandibular osteolysis?",
    "seeds": [
      "Mandibular osteolysis"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00604",
    "question": "What is associated with Tube feeding?",
    "seeds": [
      "Tube feeding"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00605",
    "question": "What is associated with Absent paranasal sinuses?",
    "seeds": [
      "Absent paranasal sinuses"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the sinuses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00606",
    "question": "What is associated with Decreased HDL3a concentration?",
    "seeds": [
      "Decreased HDL3a concentration"
    ],
    "gold_answer": "Abnormal HDL cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00607",
    "question": "What is associated with Abnormal plasma cell count?",
    "seeds": [
      "Abnormal plasma cell count"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00608",
    "question": "What is associated with Goiter, multinodular 2?",
    "seeds": [
      "Goiter, multinodular 2"
    ],
    "gold_answer": "Goiter",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00609",
    "question": "What is associated with Abnormality of the urinary system?",
    "seeds": [
      "Abnormality of the urinary system"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00610",
    "question": "What is associated with Abnormal immunoglobulin level in body fluid?",
    "seeds": [
      "Abnormal immunoglobulin level in body fluid"
    ],
    "gold_answer": "Abnormal leukocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00611",
    "question": "What is associated with Abnormality of prothrombin?",
    "seeds": [
      "Abnormality of prothrombin"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00612",
    "question": "What is associated with Auditory neuropathy, autosomal dominant 2?",
    "seeds": [
      "Auditory neuropathy, autosomal dominant 2"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00613",
    "question": "What phenotype is associated with Rabies?",
    "seeds": [
      "Rabies"
    ],
    "gold_answer": "Anxiety",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00614",
    "question": "What is associated with Gomez-Lopez-Hernandez syndrome?",
    "seeds": [
      "Gomez-Lopez-Hernandez syndrome"
    ],
    "gold_answer": "Large fontanelles",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00615",
    "question": "What is associated with Cardiac teratoma?",
    "seeds": [
      "Cardiac teratoma"
    ],
    "gold_answer": "Embryonal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00616",
    "question": "What is associated with Abnormal pulse?",
    "seeds": [
      "Abnormal pulse"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00617",
    "question": "What is associated with Broad phalanges of the 5th finger?",
    "seeds": [
      "Broad phalanges of the 5th finger"
    ],
    "gold_answer": "Broad phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00618",
    "question": "What is associated with Woods syndrome?",
    "seeds": [
      "Woods syndrome"
    ],
    "gold_answer": "Limited elbow movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00619",
    "question": "What is associated with Paroxysmal tonic upgaze?",
    "seeds": [
      "Paroxysmal tonic upgaze"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00620",
    "question": "What is associated with Bent long bone?",
    "seeds": [
      "Bent long bone"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00621",
    "question": "What is associated with Abnormal alpha granules?",
    "seeds": [
      "Abnormal alpha granules"
    ],
    "gold_answer": "Abnormality of thrombocytes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00622",
    "question": "What is associated with Sensory exotropia?",
    "seeds": [
      "Sensory exotropia"
    ],
    "gold_answer": "Exodeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00623",
    "question": "What is associated with Forward slanting upper incisors?",
    "seeds": [
      "Forward slanting upper incisors"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00624",
    "question": "What is associated with Idiopathic/heritable pulmonary arterial hypertension?",
    "seeds": [
      "Idiopathic/heritable pulmonary arterial hypertension"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00625",
    "question": "What is associated with Left axis deviation?",
    "seeds": [
      "Left axis deviation"
    ],
    "gold_answer": "Abnormal ventricular axis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00626",
    "question": "What phenotype is associated with Silver-Russell syndrome 4?",
    "seeds": [
      "Silver-Russell syndrome 4"
    ],
    "gold_answer": "Feeding difficulties in infancy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00627",
    "question": "What is associated with Leber congenital amaurosis-3 (LCA3)/Retinitis pigmentosa, juvenile, autosomal recessive?",
    "seeds": [
      "Leber congenital amaurosis-3 (LCA3)/Retinitis pigmentosa, juvenile, autosomal recessive"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00628",
    "question": "What is associated with Weill-Marchesani syndrome 1?",
    "seeds": [
      "Weill-Marchesani syndrome 1"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00629",
    "question": "What phenotype is associated with Cardiac diverticulum?",
    "seeds": [
      "Cardiac diverticulum"
    ],
    "gold_answer": "Thin vermilion border",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00630",
    "question": "What is associated with Onychogryphosis of toenails?",
    "seeds": [
      "Onychogryphosis of toenails"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00631",
    "question": "What is associated with Autoimmunity?",
    "seeds": [
      "Autoimmunity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00632",
    "question": "What is associated with Exercise-induced malignant hyperthermia?",
    "seeds": [
      "Exercise-induced malignant hyperthermia"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00633",
    "question": "What is associated with Von Willebrand disease?",
    "seeds": [
      "Von Willebrand disease"
    ],
    "gold_answer": "Internal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00634",
    "question": "What is associated with Persistent cloaca?",
    "seeds": [
      "Persistent cloaca"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00635",
    "question": "What is associated with Hyperalaninemia?",
    "seeds": [
      "Hyperalaninemia"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid derivative concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00636",
    "question": "What is associated with Fibrin casts?",
    "seeds": [
      "Fibrin casts"
    ],
    "gold_answer": "Abnormal bronchus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00637",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 65?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 65"
    ],
    "gold_answer": "Macrotia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00638",
    "question": "What is associated with Hypermobility of interphalangeal joints?",
    "seeds": [
      "Hypermobility of interphalangeal joints"
    ],
    "gold_answer": "Joint hypermobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00639",
    "question": "What is associated with Synostosis involving bones of the lower limbs?",
    "seeds": [
      "Synostosis involving bones of the lower limbs"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00640",
    "question": "What is associated with Reduced tissue mannosyl-oligosaccharide glucosidase activity?",
    "seeds": [
      "Reduced tissue mannosyl-oligosaccharide glucosidase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00641",
    "question": "What is associated with Abnormal gastrointestinal motility?",
    "seeds": [
      "Abnormal gastrointestinal motility"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00642",
    "question": "What phenotype is associated with Immunodeficiency 77?",
    "seeds": [
      "Immunodeficiency 77"
    ],
    "gold_answer": "Recurrent tonsillitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00643",
    "question": "What is associated with Vitamin D hydroxylation-deficient rickets, type 1B?",
    "seeds": [
      "Vitamin D hydroxylation-deficient rickets, type 1B"
    ],
    "gold_answer": "Enlarged epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00644",
    "question": "What is associated with Increased intracranial pressure?",
    "seeds": [
      "Increased intracranial pressure"
    ],
    "gold_answer": "Abnormality of intracranial pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00645",
    "question": "What is associated with Irregularly spaced teeth?",
    "seeds": [
      "Irregularly spaced teeth"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00646",
    "question": "What is associated with Mesangial proliferative lupus nephritis?",
    "seeds": [
      "Mesangial proliferative lupus nephritis"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00647",
    "question": "What is associated with Midline facial cleft?",
    "seeds": [
      "Midline facial cleft"
    ],
    "gold_answer": "Tessier cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00648",
    "question": "What is associated with Broad radius?",
    "seeds": [
      "Broad radius"
    ],
    "gold_answer": "Broad forearm bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00649",
    "question": "What is associated with Elevated CSF N-carbamyl-beta-aminoisobutyric acid concentration?",
    "seeds": [
      "Elevated CSF N-carbamyl-beta-aminoisobutyric acid concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00650",
    "question": "What is associated with Abnormal mandible coronoid process morphology?",
    "seeds": [
      "Abnormal mandible coronoid process morphology"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00651",
    "question": "What is associated with Abnormal pulse?",
    "seeds": [
      "Abnormal pulse"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00652",
    "question": "What is associated with Multiple mitochondrial dysfunctions syndrome 4?",
    "seeds": [
      "Multiple mitochondrial dysfunctions syndrome 4"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00653",
    "question": "What is associated with Iris hypoperfusion?",
    "seeds": [
      "Iris hypoperfusion"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00654",
    "question": "What is associated with Midline liver?",
    "seeds": [
      "Midline liver"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00655",
    "question": "What phenotype is associated with Stickler syndrome type 2?",
    "seeds": [
      "Stickler syndrome type 2"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00656",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 9A?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 9A"
    ],
    "gold_answer": "Dysarthria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00657",
    "question": "What is associated with Elevated monolysocardiolipin/cardiolipin ratio?",
    "seeds": [
      "Elevated monolysocardiolipin/cardiolipin ratio"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00658",
    "question": "What is associated with Cone-shaped epiphysis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Cone-shaped epiphysis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Cone-shaped epiphyses of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00659",
    "question": "What is associated with Social disinhibition?",
    "seeds": [
      "Social disinhibition"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00660",
    "question": "What is associated with Increased HDL3a concentration?",
    "seeds": [
      "Increased HDL3a concentration"
    ],
    "gold_answer": "Abnormal HDL3a concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00661",
    "question": "What is associated with Short digit?",
    "seeds": [
      "Short digit"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00662",
    "question": "What is associated with Hip subluxation?",
    "seeds": [
      "Hip subluxation"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00663",
    "question": "What is associated with Nil-Deshwar neurodevelopmental syndrome?",
    "seeds": [
      "Nil-Deshwar neurodevelopmental syndrome"
    ],
    "gold_answer": "Abnormal cheek morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00664",
    "question": "What is associated with Exudative vitreoretinopathy 5?",
    "seeds": [
      "Exudative vitreoretinopathy 5"
    ],
    "gold_answer": "Retinal detachment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00665",
    "question": "What phenotype is associated with Branchio-oculo-facial syndrome?",
    "seeds": [
      "Branchio-oculo-facial syndrome"
    ],
    "gold_answer": "Oligohydramnios",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00666",
    "question": "What is associated with Incisor macrodontia?",
    "seeds": [
      "Incisor macrodontia"
    ],
    "gold_answer": "Abnormal incisor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00667",
    "question": "What is associated with Bicuspid aortic valve with left-noncoronary cusp fusion?",
    "seeds": [
      "Bicuspid aortic valve with left-noncoronary cusp fusion"
    ],
    "gold_answer": "Bicuspid aortic valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00668",
    "question": "What is associated with Characteristic of mass?",
    "seeds": [
      "Characteristic of mass"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00669",
    "question": "What is associated with Hemorrhoids?",
    "seeds": [
      "Hemorrhoids"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00670",
    "question": "What phenotype is associated with Medulloblastoma?",
    "seeds": [
      "Medulloblastoma"
    ],
    "gold_answer": "Antalgic gait",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00671",
    "question": "What is associated with Deafness, autosomal dominant 74?",
    "seeds": [
      "Deafness, autosomal dominant 74"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00672",
    "question": "What is associated with Duplication of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Duplication of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Duplication of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00673",
    "question": "What is associated with Abnormal circulating calcitonin concentration?",
    "seeds": [
      "Abnormal circulating calcitonin concentration"
    ],
    "gold_answer": "Acute phase response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00674",
    "question": "What is associated with Decreased urinary uromodulin level?",
    "seeds": [
      "Decreased urinary uromodulin level"
    ],
    "gold_answer": "Abnormal urinary uromodulin level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00675",
    "question": "What is associated with Increased female libido?",
    "seeds": [
      "Increased female libido"
    ],
    "gold_answer": "Female sexual dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00676",
    "question": "What is associated with Cushing syndrome due to ectopic ACTH secretion?",
    "seeds": [
      "Cushing syndrome due to ectopic ACTH secretion"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00677",
    "question": "What is associated with Occupational history of putting fingers in other people's mouths?",
    "seeds": [
      "Occupational history of putting fingers in other people's mouths"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00678",
    "question": "What is associated with Autophony?",
    "seeds": [
      "Autophony"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00679",
    "question": "What is associated with Abnormal circulating aromatic amino acid concentration?",
    "seeds": [
      "Abnormal circulating aromatic amino acid concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00680",
    "question": "What is associated with Abnormal circulating progesterone level?",
    "seeds": [
      "Abnormal circulating progesterone level"
    ],
    "gold_answer": "Abnormal circulating sex hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00681",
    "question": "What is associated with Localized to the lower eyelid?",
    "seeds": [
      "Localized to the lower eyelid"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00682",
    "question": "What is associated with Patulous urethra?",
    "seeds": [
      "Patulous urethra"
    ],
    "gold_answer": "Abnormality of the urinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00683",
    "question": "What phenotype is associated with Phosphoserine aminotransferase deficiency?",
    "seeds": [
      "Phosphoserine aminotransferase deficiency"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00684",
    "question": "What is associated with Congenital hepatic fibrosis?",
    "seeds": [
      "Congenital hepatic fibrosis"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00685",
    "question": "What is associated with Postsynaptic congenital myasthenic syndrome?",
    "seeds": [
      "Postsynaptic congenital myasthenic syndrome"
    ],
    "gold_answer": "Abnormality of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00686",
    "question": "What is associated with Retinitis?",
    "seeds": [
      "Retinitis"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00687",
    "question": "What is associated with Cardiomyopathy, dilated, 1C, with or without left ventricular noncompaction?",
    "seeds": [
      "Cardiomyopathy, dilated, 1C, with or without left ventricular noncompaction"
    ],
    "gold_answer": "Abnormal morphology of myocardial trabeculae",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00688",
    "question": "What is associated with Single interphalangeal crease of fifth finger?",
    "seeds": [
      "Single interphalangeal crease of fifth finger"
    ],
    "gold_answer": "Absent phalangeal crease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00689",
    "question": "What is associated with Xanthoma of bone?",
    "seeds": [
      "Xanthoma of bone"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00690",
    "question": "What is associated with Positive modified dynamic labral shear test?",
    "seeds": [
      "Positive modified dynamic labral shear test"
    ],
    "gold_answer": "Abnormal shoulder physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00691",
    "question": "What is associated with Intracranial internal carotid artery dissection?",
    "seeds": [
      "Intracranial internal carotid artery dissection"
    ],
    "gold_answer": "Carotid artery dissection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00692",
    "question": "What is associated with Perihilar glomerular hyalinosis?",
    "seeds": [
      "Perihilar glomerular hyalinosis"
    ],
    "gold_answer": "Glomerular hyalinosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00693",
    "question": "What is associated with Macrocephaly/autism syndrome?",
    "seeds": [
      "Macrocephaly/autism syndrome"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00694",
    "question": "What is associated with Attenuation of retinal blood vessels?",
    "seeds": [
      "Attenuation of retinal blood vessels"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00695",
    "question": "What is associated with Long fingers?",
    "seeds": [
      "Long fingers"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00696",
    "question": "What is associated with Thoracocervical ectopia cordis?",
    "seeds": [
      "Thoracocervical ectopia cordis"
    ],
    "gold_answer": "Ectopia cordis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00697",
    "question": "What phenotype is associated with Fetal trimethadione syndrome?",
    "seeds": [
      "Fetal trimethadione syndrome"
    ],
    "gold_answer": "Ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00698",
    "question": "What is associated with Multiple pulmonary interstitial hyalinized nodules?",
    "seeds": [
      "Multiple pulmonary interstitial hyalinized nodules"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00699",
    "question": "What is associated with Neonatal cholestatic liver disease?",
    "seeds": [
      "Neonatal cholestatic liver disease"
    ],
    "gold_answer": "Cholestatic liver disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00700",
    "question": "What is associated with Neuropathy, congenital hypomyelinating, 1, autosomal recessive?",
    "seeds": [
      "Neuropathy, congenital hypomyelinating, 1, autosomal recessive"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00701",
    "question": "What is associated with Eruptive vellus hair cyst?",
    "seeds": [
      "Eruptive vellus hair cyst"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00702",
    "question": "What phenotype is associated with Cleft velum?",
    "seeds": [
      "Cleft velum"
    ],
    "gold_answer": "Poor suck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00703",
    "question": "What is associated with Hypertrophic osteoarthropathy, primary, autosomal dominant?",
    "seeds": [
      "Hypertrophic osteoarthropathy, primary, autosomal dominant"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00704",
    "question": "What is associated with Pulmonary hamartoma?",
    "seeds": [
      "Pulmonary hamartoma"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00705",
    "question": "What is associated with Radial bowing?",
    "seeds": [
      "Radial bowing"
    ],
    "gold_answer": "Bowing of the arm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00706",
    "question": "What is associated with Duplication of the proximal phalanx of hand?",
    "seeds": [
      "Duplication of the proximal phalanx of hand"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00707",
    "question": "What is associated with Cysticercosis?",
    "seeds": [
      "Cysticercosis"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00708",
    "question": "What phenotype is associated with Progressive microcephaly-seizures-cortical blindness-developmental delay syndrome?",
    "seeds": [
      "Progressive microcephaly-seizures-cortical blindness-developmental delay syndrome"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00709",
    "question": "What is associated with GM1 gangliosidosis?",
    "seeds": [
      "GM1 gangliosidosis"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00710",
    "question": "What is associated with Snail-like ilia?",
    "seeds": [
      "Snail-like ilia"
    ],
    "gold_answer": "Abnormal hip bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00711",
    "question": "What is associated with Congenital disorder of glycosylation, type IIt?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIt"
    ],
    "gold_answer": "Central nervous system cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00712",
    "question": "What is associated with Breathing dysregulation?",
    "seeds": [
      "Breathing dysregulation"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00713",
    "question": "What is associated with Decreased number of sternal ossification centers?",
    "seeds": [
      "Decreased number of sternal ossification centers"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00714",
    "question": "What is associated with Retinal degeneration?",
    "seeds": [
      "Retinal degeneration"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00715",
    "question": "What is associated with Pleural thickening?",
    "seeds": [
      "Pleural thickening"
    ],
    "gold_answer": "Abnormal pleura morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00716",
    "question": "What is associated with Abnormal brainstem morphology?",
    "seeds": [
      "Abnormal brainstem morphology"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00717",
    "question": "What is associated with Multiple glomerular cysts?",
    "seeds": [
      "Multiple glomerular cysts"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00718",
    "question": "What is associated with Elevated circulating CXCL9 concentration?",
    "seeds": [
      "Elevated circulating CXCL9 concentration"
    ],
    "gold_answer": "Abnormal immune serum protein physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00719",
    "question": "What is associated with Anti-Zic4 antibody positivity?",
    "seeds": [
      "Anti-Zic4 antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00720",
    "question": "What is associated with Best corrected visual acuity 2.0 LogMAR?",
    "seeds": [
      "Best corrected visual acuity 2.0 LogMAR"
    ],
    "gold_answer": "Abnormal best corrected visual acuity test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00721",
    "question": "What is associated with Absent brainstem auditory responses?",
    "seeds": [
      "Absent brainstem auditory responses"
    ],
    "gold_answer": "Abnormal auditory evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00722",
    "question": "What is associated with Mitochondrial complex IV deficiency, nuclear type 20?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 20"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00723",
    "question": "What is associated with Tracheal duplication cyst?",
    "seeds": [
      "Tracheal duplication cyst"
    ],
    "gold_answer": "Abnormal tracheal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00724",
    "question": "What is associated with Abnormal ventricular filling?",
    "seeds": [
      "Abnormal ventricular filling"
    ],
    "gold_answer": "Abnormal cardiac ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00725",
    "question": "What is associated with Multifocal seizures?",
    "seeds": [
      "Multifocal seizures"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00726",
    "question": "What is associated with Mucopolysaccharidosis IVA?",
    "seeds": [
      "Mucopolysaccharidosis IVA"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00727",
    "question": "What phenotype is associated with Spondyloepimetaphyseal dysplasia, Li-Shao-Li type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, Li-Shao-Li type"
    ],
    "gold_answer": "Waddling gait",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00728",
    "question": "What is associated with Oocyte/zygote/embryo maturation arrest 20?",
    "seeds": [
      "Oocyte/zygote/embryo maturation arrest 20"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00729",
    "question": "What is associated with Anti-voltage-gated potassium channel antibody positivity?",
    "seeds": [
      "Anti-voltage-gated potassium channel antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00730",
    "question": "What is associated with Agenesis of the anterior commissure?",
    "seeds": [
      "Agenesis of the anterior commissure"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00731",
    "question": "What is associated with Thin long bone diaphyses?",
    "seeds": [
      "Thin long bone diaphyses"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00732",
    "question": "What is associated with High dietary oxalate intake?",
    "seeds": [
      "High dietary oxalate intake"
    ],
    "gold_answer": "Nutrition history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00733",
    "question": "What is associated with Pyuria?",
    "seeds": [
      "Pyuria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00734",
    "question": "What is associated with Congenital disorder of glycosylation, type I/IIx?",
    "seeds": [
      "Congenital disorder of glycosylation, type I/IIx"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00735",
    "question": "What is associated with Ichthyosis hystrix of Curth-Macklin?",
    "seeds": [
      "Ichthyosis hystrix of Curth-Macklin"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00736",
    "question": "What phenotype is associated with Peroxisome biogenesis disorder 5B?",
    "seeds": [
      "Peroxisome biogenesis disorder 5B"
    ],
    "gold_answer": "Unsteady gait",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00737",
    "question": "What is associated with Myasthenic syndrome, congenital, 20, presynaptic?",
    "seeds": [
      "Myasthenic syndrome, congenital, 20, presynaptic"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00738",
    "question": "What is associated with Elevated erythrocyte galactose-1-phosphate concentration?",
    "seeds": [
      "Elevated erythrocyte galactose-1-phosphate concentration"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00739",
    "question": "What is associated with Galloway-Mowat syndrome 2, X-linked?",
    "seeds": [
      "Galloway-Mowat syndrome 2, X-linked"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00740",
    "question": "What is associated with Cleft maxillary alveolar ridge?",
    "seeds": [
      "Cleft maxillary alveolar ridge"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00741",
    "question": "What is associated with Decreased circulating beta-carotene concentration?",
    "seeds": [
      "Decreased circulating beta-carotene concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00742",
    "question": "What phenotype is associated with Bilateral parasagittal parieto-occipital polymicrogyria?",
    "seeds": [
      "Bilateral parasagittal parieto-occipital polymicrogyria"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00743",
    "question": "What is associated with Intradural spinal lipoma?",
    "seeds": [
      "Intradural spinal lipoma"
    ],
    "gold_answer": "Lipoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00744",
    "question": "What is associated with Absence of epidermal lamellar bodies?",
    "seeds": [
      "Absence of epidermal lamellar bodies"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00745",
    "question": "What is associated with Recurrent deep organ abscess formation?",
    "seeds": [
      "Recurrent deep organ abscess formation"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00746",
    "question": "What is associated with Proximal spinal muscular atrophy type 1?",
    "seeds": [
      "Proximal spinal muscular atrophy type 1"
    ],
    "gold_answer": "NAIP",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "modifying_germline_mutation_in"
    }
  },
  {
    "query_id": "orph_test_00747",
    "question": "What phenotype is associated with Leber-like hereditary optic neuropathy, autosomal recessive 2?",
    "seeds": [
      "Leber-like hereditary optic neuropathy, autosomal recessive 2"
    ],
    "gold_answer": "Centrocecal scotoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00748",
    "question": "What is associated with X-linked external auditory canal atresia-dilated internal auditory canal-facial dysmorphism syndrome?",
    "seeds": [
      "X-linked external auditory canal atresia-dilated internal auditory canal-facial dysmorphism syndrome"
    ],
    "gold_answer": "GPRASP2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00749",
    "question": "What is associated with Puerpural onset?",
    "seeds": [
      "Puerpural onset"
    ],
    "gold_answer": "Clinical course",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00750",
    "question": "What phenotype is associated with Central neurocytoma?",
    "seeds": [
      "Central neurocytoma"
    ],
    "gold_answer": "Coma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00751",
    "question": "What is associated with Triangular epiphyses of the 4th finger?",
    "seeds": [
      "Triangular epiphyses of the 4th finger"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00752",
    "question": "What is associated with Fractured proximal phalanx of digit 5?",
    "seeds": [
      "Fractured proximal phalanx of digit 5"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00753",
    "question": "What is associated with Long phalanx of finger?",
    "seeds": [
      "Long phalanx of finger"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00754",
    "question": "What phenotype is associated with Cholestasis, benign recurrent intrahepatic, 2?",
    "seeds": [
      "Cholestasis, benign recurrent intrahepatic, 2"
    ],
    "gold_answer": "Elevated circulating alkaline phosphatase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00755",
    "question": "What is associated with Heart murmur?",
    "seeds": [
      "Heart murmur"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00756",
    "question": "What is associated with Hypotonia, infantile, with psychomotor retardation?",
    "seeds": [
      "Hypotonia, infantile, with psychomotor retardation"
    ],
    "gold_answer": "Abnormal cardiac septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00757",
    "question": "What is associated with Elevated bone marrow ring sideroblast count?",
    "seeds": [
      "Elevated bone marrow ring sideroblast count"
    ],
    "gold_answer": "Abnormal bone marrow cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00758",
    "question": "What is associated with Swollen lip?",
    "seeds": [
      "Swollen lip"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00759",
    "question": "What is associated with Olivopontocerebellar hypoplasia?",
    "seeds": [
      "Olivopontocerebellar hypoplasia"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00760",
    "question": "What is associated with Gracile syndrome?",
    "seeds": [
      "Gracile syndrome"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00761",
    "question": "What is associated with Myocarditis?",
    "seeds": [
      "Myocarditis"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00762",
    "question": "What is associated with Right ventricular regional dyskinesia?",
    "seeds": [
      "Right ventricular regional dyskinesia"
    ],
    "gold_answer": "Abnormal cardiac ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00763",
    "question": "What phenotype is associated with Spondyloepiphyseal dysplasia tarda with characteristic facies?",
    "seeds": [
      "Spondyloepiphyseal dysplasia tarda with characteristic facies"
    ],
    "gold_answer": "Broad nasal tip",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00764",
    "question": "What phenotype is associated with Short stature and microcephaly with genital anomalies?",
    "seeds": [
      "Short stature and microcephaly with genital anomalies"
    ],
    "gold_answer": "Delayed thelarche",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00765",
    "question": "What is associated with Ependymoblastoma?",
    "seeds": [
      "Ependymoblastoma"
    ],
    "gold_answer": "Central primitive neuroectodermal tumor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00766",
    "question": "What phenotype is associated with Neurodevelopmental disorder with seizures and gingival overgrowth?",
    "seeds": [
      "Neurodevelopmental disorder with seizures and gingival overgrowth"
    ],
    "gold_answer": "Slurred speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00767",
    "question": "What is associated with Cleft vertebral arch?",
    "seeds": [
      "Cleft vertebral arch"
    ],
    "gold_answer": "Vertebral arch anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00768",
    "question": "What is associated with Absent middle phalanx of 5th finger?",
    "seeds": [
      "Absent middle phalanx of 5th finger"
    ],
    "gold_answer": "Aplasia of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00769",
    "question": "What is associated with Narrow anterio-posterior vertebral body diameter?",
    "seeds": [
      "Narrow anterio-posterior vertebral body diameter"
    ],
    "gold_answer": "Vertebral hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00770",
    "question": "What phenotype is associated with Neurodevelopmental disorder with seizures, spasticity, and complete or partial agenesis of the corpus callosum?",
    "seeds": [
      "Neurodevelopmental disorder with seizures, spasticity, and complete or partial agenesis of the corpus callosum"
    ],
    "gold_answer": "Respiratory insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00771",
    "question": "What phenotype is associated with Bangstad syndrome?",
    "seeds": [
      "Bangstad syndrome"
    ],
    "gold_answer": "Cerebral hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00772",
    "question": "What is associated with Bundle branch block, familial isolated complete right?",
    "seeds": [
      "Bundle branch block, familial isolated complete right"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00773",
    "question": "What is associated with Defective B cell differentiation?",
    "seeds": [
      "Defective B cell differentiation"
    ],
    "gold_answer": "Defective B cell activation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00774",
    "question": "What phenotype is associated with Spastic paraplegia 86, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 86, autosomal recessive"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00775",
    "question": "What is associated with HNF1B-related autosomal dominant tubulointerstitial kidney disease?",
    "seeds": [
      "HNF1B-related autosomal dominant tubulointerstitial kidney disease"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00776",
    "question": "What phenotype is associated with Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00777",
    "question": "What is associated with Limited ankle dorsiflexion?",
    "seeds": [
      "Limited ankle dorsiflexion"
    ],
    "gold_answer": "Abnormal ankle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00778",
    "question": "What is associated with Eales disease?",
    "seeds": [
      "Eales disease"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00779",
    "question": "What phenotype is associated with Moderate hemophilia A?",
    "seeds": [
      "Moderate hemophilia A"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00780",
    "question": "What is associated with Germinal center B-lymphocyte BCL2 expression?",
    "seeds": [
      "Germinal center B-lymphocyte BCL2 expression"
    ],
    "gold_answer": "Abnormal lymph-node cellular antigen expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00781",
    "question": "What is associated with Tricho-retino-dento-digital syndrome?",
    "seeds": [
      "Tricho-retino-dento-digital syndrome"
    ],
    "gold_answer": "Abnormality of hair texture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00782",
    "question": "What phenotype is associated with Nager syndrome?",
    "seeds": [
      "Nager syndrome"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00783",
    "question": "What is associated with Renal arteriole lymphocyte endoarterial hypercellularity?",
    "seeds": [
      "Renal arteriole lymphocyte endoarterial hypercellularity"
    ],
    "gold_answer": "Abnormal renal arteriole endothelium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00784",
    "question": "What is associated with Autosomal recessive myosin storage myopathy?",
    "seeds": [
      "Autosomal recessive myosin storage myopathy"
    ],
    "gold_answer": "MYH7",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00785",
    "question": "What is associated with Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy?",
    "seeds": [
      "Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy"
    ],
    "gold_answer": "Ventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00786",
    "question": "What is associated with Painless mass?",
    "seeds": [
      "Painless mass"
    ],
    "gold_answer": "Characteristic of mass",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00787",
    "question": "What is associated with Absent bronchoalveolar dimeric surfactant-protein B?",
    "seeds": [
      "Absent bronchoalveolar dimeric surfactant-protein B"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00788",
    "question": "What is associated with Splenic lipid-laden macrophage infiltration?",
    "seeds": [
      "Splenic lipid-laden macrophage infiltration"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00789",
    "question": "What is associated with Restlessness?",
    "seeds": [
      "Restlessness"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00790",
    "question": "What is associated with Abnormal urine citrate concentration?",
    "seeds": [
      "Abnormal urine citrate concentration"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00791",
    "question": "What is associated with Neurocardiofaciodigital syndrome?",
    "seeds": [
      "Neurocardiofaciodigital syndrome"
    ],
    "gold_answer": "GJA5",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_test_00792",
    "question": "What is associated with Lymphedema?",
    "seeds": [
      "Lymphedema"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00793",
    "question": "What is associated with Cone-shaped epiphyses of the 4th finger?",
    "seeds": [
      "Cone-shaped epiphyses of the 4th finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00794",
    "question": "What phenotype is associated with Delayed sleep phase disorder, susceptibility to?",
    "seeds": [
      "Delayed sleep phase disorder, susceptibility to"
    ],
    "gold_answer": "Sleep onset insomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00795",
    "question": "What is associated with Trigonocephaly?",
    "seeds": [
      "Trigonocephaly"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00796",
    "question": "What phenotype is associated with Blepharophimosis with facial and genital anomalies and impaired intellectual development?",
    "seeds": [
      "Blepharophimosis with facial and genital anomalies and impaired intellectual development"
    ],
    "gold_answer": "Low anterior hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00797",
    "question": "What is associated with Loeffler endocarditis?",
    "seeds": [
      "Loeffler endocarditis"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00798",
    "question": "What is associated with Fetal onset?",
    "seeds": [
      "Fetal onset"
    ],
    "gold_answer": "Onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00799",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 36?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 36"
    ],
    "gold_answer": "Self-mutilation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00800",
    "question": "What is associated with Perinuclear antineutrophil antibody positivity?",
    "seeds": [
      "Perinuclear antineutrophil antibody positivity"
    ],
    "gold_answer": "Antineutrophil antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00801",
    "question": "What is associated with Sudden infant death-dysgenesis of the testes syndrome?",
    "seeds": [
      "Sudden infant death-dysgenesis of the testes syndrome"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00802",
    "question": "What is associated with BRESEK syndrome?",
    "seeds": [
      "BRESEK syndrome"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00803",
    "question": "What is associated with Maldevelopment of radioulnar joint?",
    "seeds": [
      "Maldevelopment of radioulnar joint"
    ],
    "gold_answer": "Abnormal forearm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00804",
    "question": "What is associated with 3-methylglutaconic aciduria type 4?",
    "seeds": [
      "3-methylglutaconic aciduria type 4"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00805",
    "question": "What is associated with 1-2 toe complete cutaneous syndactyly?",
    "seeds": [
      "1-2 toe complete cutaneous syndactyly"
    ],
    "gold_answer": "Toe syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00806",
    "question": "What is associated with Abnormal bronchus morphology?",
    "seeds": [
      "Abnormal bronchus morphology"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00807",
    "question": "What is associated with Hyperbilirubinemia?",
    "seeds": [
      "Hyperbilirubinemia"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00808",
    "question": "What is associated with Cutaneous telangiectasia?",
    "seeds": [
      "Cutaneous telangiectasia"
    ],
    "gold_answer": "Telangiectasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00809",
    "question": "What is associated with Irregular epiphysis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Irregular epiphysis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the middle phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00810",
    "question": "What is associated with Brugada syndrome?",
    "seeds": [
      "Brugada syndrome"
    ],
    "gold_answer": "Abnormal electrophysiology of sinoatrial node origin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00811",
    "question": "What is associated with Abnormal circulating fatty-acid anion concentration?",
    "seeds": [
      "Abnormal circulating fatty-acid anion concentration"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00812",
    "question": "What is associated with Postinfectious vasculitis?",
    "seeds": [
      "Postinfectious vasculitis"
    ],
    "gold_answer": "Recurrent bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00813",
    "question": "What phenotype is associated with Encephalopathy, progressive, early-onset, with brain atrophy and spasticity?",
    "seeds": [
      "Encephalopathy, progressive, early-onset, with brain atrophy and spasticity"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00814",
    "question": "What is associated with Hypertrichosis, congenital generalized?",
    "seeds": [
      "Hypertrichosis, congenital generalized"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00815",
    "question": "What phenotype is associated with Epiphyseal dysplasia, multiple, with myopia and conductive deafness?",
    "seeds": [
      "Epiphyseal dysplasia, multiple, with myopia and conductive deafness"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00816",
    "question": "What is associated with Fungi allergy?",
    "seeds": [
      "Fungi allergy"
    ],
    "gold_answer": "Allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00817",
    "question": "What is associated with Pediculosis capitis?",
    "seeds": [
      "Pediculosis capitis"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00818",
    "question": "What is associated with Growth retardation, developmental delay, coarse facies, and earlydeath?",
    "seeds": [
      "Growth retardation, developmental delay, coarse facies, and earlydeath"
    ],
    "gold_answer": "Dilated fourth ventricle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00819",
    "question": "What is associated with Subfoveal choroidal neovascularization?",
    "seeds": [
      "Subfoveal choroidal neovascularization"
    ],
    "gold_answer": "Abnormal morphology of the choroidal vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00820",
    "question": "What is associated with Impaired intellectual development, anterior maxillary protrusion, and strabismus?",
    "seeds": [
      "Impaired intellectual development, anterior maxillary protrusion, and strabismus"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00821",
    "question": "What is associated with Microphthalmia, isolated, with corectopia?",
    "seeds": [
      "Microphthalmia, isolated, with corectopia"
    ],
    "gold_answer": "Aplasia/Hypoplasia affecting the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00822",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 103?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 103"
    ],
    "gold_answer": "Anteverted nares",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00823",
    "question": "What is associated with Aplasia/hypoplasia involving the skeleton?",
    "seeds": [
      "Aplasia/hypoplasia involving the skeleton"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00824",
    "question": "What phenotype is associated with GENOCHONDROMATOSIS?",
    "seeds": [
      "GENOCHONDROMATOSIS"
    ],
    "gold_answer": "Metaphyseal chondromatosis of humerus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00825",
    "question": "What is associated with 4-5 finger cutaneous syndactyly?",
    "seeds": [
      "4-5 finger cutaneous syndactyly"
    ],
    "gold_answer": "Syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00826",
    "question": "What is associated with Irregular myelin loops?",
    "seeds": [
      "Irregular myelin loops"
    ],
    "gold_answer": "Abnormal peripheral myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00827",
    "question": "What is associated with Seborrheic keratosis?",
    "seeds": [
      "Seborrheic keratosis"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00828",
    "question": "What phenotype is associated with Autosomal recessive omodysplasia?",
    "seeds": [
      "Autosomal recessive omodysplasia"
    ],
    "gold_answer": "Rhizomelia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00829",
    "question": "What is associated with Infantile constant exotropia?",
    "seeds": [
      "Infantile constant exotropia"
    ],
    "gold_answer": "Exotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00830",
    "question": "What is associated with Exacerbated by pulmonary vasodilator exposure?",
    "seeds": [
      "Exacerbated by pulmonary vasodilator exposure"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00831",
    "question": "What is associated with Decreased circulating copper concentration?",
    "seeds": [
      "Decreased circulating copper concentration"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00832",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 73?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 73"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00833",
    "question": "What phenotype is associated with 14q24.1q24.3 microdeletion syndrome?",
    "seeds": [
      "14q24.1q24.3 microdeletion syndrome"
    ],
    "gold_answer": "Ectopic kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00834",
    "question": "What is associated with Periodic?",
    "seeds": [
      "Periodic"
    ],
    "gold_answer": "Clinical course",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00835",
    "question": "What is associated with Breech presentation?",
    "seeds": [
      "Breech presentation"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00836",
    "question": "What is associated with Young adult onset?",
    "seeds": [
      "Young adult onset"
    ],
    "gold_answer": "Onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00837",
    "question": "What is associated with Hypogonadotropic hypogonadism 27 without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 27 without anosmia"
    ],
    "gold_answer": "Abnormal response to gonadotropin-releasing hormone stimulation test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00838",
    "question": "What is associated with Anti-annexin-V antibody positivity?",
    "seeds": [
      "Anti-annexin-V antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00839",
    "question": "What is associated with Dermatofibrosarcoma protuberans?",
    "seeds": [
      "Dermatofibrosarcoma protuberans"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00840",
    "question": "What phenotype is associated with Fused mandibular incisors?",
    "seeds": [
      "Fused mandibular incisors"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00841",
    "question": "What is associated with Abnormal glomerular visceral epithelial cell morphology?",
    "seeds": [
      "Abnormal glomerular visceral epithelial cell morphology"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00842",
    "question": "What is associated with Temporomandibular joint adhesion?",
    "seeds": [
      "Temporomandibular joint adhesion"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00843",
    "question": "What is associated with Abnormal ethmoid bone morphology?",
    "seeds": [
      "Abnormal ethmoid bone morphology"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00844",
    "question": "What is associated with Thrombophilia due to thrombomodulin defect?",
    "seeds": [
      "Thrombophilia due to thrombomodulin defect"
    ],
    "gold_answer": "Venous thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00845",
    "question": "What is associated with Complete duplication of the distal phalanx of the 5th finger?",
    "seeds": [
      "Complete duplication of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00846",
    "question": "What is associated with Punctate corneal epithelial erosions?",
    "seeds": [
      "Punctate corneal epithelial erosions"
    ],
    "gold_answer": "Abnormal corneal epithelium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00847",
    "question": "What is associated with Impaired thrombin-induced platelet aggregation?",
    "seeds": [
      "Impaired thrombin-induced platelet aggregation"
    ],
    "gold_answer": "Abnormal platelet function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00848",
    "question": "What is associated with Broad distal phalanges of all fingers?",
    "seeds": [
      "Broad distal phalanges of all fingers"
    ],
    "gold_answer": "Abnormal distal phalanx morphology of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00849",
    "question": "What is associated with Hepatocellular necrosis?",
    "seeds": [
      "Hepatocellular necrosis"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00850",
    "question": "What is associated with Pulmonary venous hypertension?",
    "seeds": [
      "Pulmonary venous hypertension"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00851",
    "question": "What is associated with DEFECTIVE INTERFERING PARTICLE INDUCTION, CONTROL OF?",
    "seeds": [
      "DEFECTIVE INTERFERING PARTICLE INDUCTION, CONTROL OF"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00852",
    "question": "What is associated with Disorder of thought content?",
    "seeds": [
      "Disorder of thought content"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00853",
    "question": "What is associated with Neonatal onset?",
    "seeds": [
      "Neonatal onset"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00854",
    "question": "What is associated with Peroxisome biogenesis disorder 1A (Zellweger)?",
    "seeds": [
      "Peroxisome biogenesis disorder 1A (Zellweger)"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00855",
    "question": "What is associated with Interstitial emphysema?",
    "seeds": [
      "Interstitial emphysema"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00856",
    "question": "What is associated with Pseudoxanthoma elasticum, forme fruste?",
    "seeds": [
      "Pseudoxanthoma elasticum, forme fruste"
    ],
    "gold_answer": "Arterial stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00857",
    "question": "What is associated with Profound global developmental delay?",
    "seeds": [
      "Profound global developmental delay"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00858",
    "question": "What is associated with Increased CD4:CD8 ratio?",
    "seeds": [
      "Increased CD4:CD8 ratio"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00859",
    "question": "What is associated with Extensor tendons of finger anomalies?",
    "seeds": [
      "Extensor tendons of finger anomalies"
    ],
    "gold_answer": "Flexion contracture of digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00860",
    "question": "What is associated with Increased level of D-threitol in plasma?",
    "seeds": [
      "Increased level of D-threitol in plasma"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00861",
    "question": "What is associated with EMG: continuous motor unit activity at rest?",
    "seeds": [
      "EMG: continuous motor unit activity at rest"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00862",
    "question": "What is associated with Atrophic, patchy alopecia?",
    "seeds": [
      "Atrophic, patchy alopecia"
    ],
    "gold_answer": "Abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00863",
    "question": "What is associated with Capitate-hamate fusion?",
    "seeds": [
      "Capitate-hamate fusion"
    ],
    "gold_answer": "Abnormal capitate bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00864",
    "question": "What is associated with Aortic regurgitation?",
    "seeds": [
      "Aortic regurgitation"
    ],
    "gold_answer": "Abnormal aortic valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00865",
    "question": "What is associated with Vesicovaginal fistula?",
    "seeds": [
      "Vesicovaginal fistula"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00866",
    "question": "What is associated with Prelingual sensorineural hearing impairment?",
    "seeds": [
      "Prelingual sensorineural hearing impairment"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00867",
    "question": "What phenotype is associated with Sialuria?",
    "seeds": [
      "Sialuria"
    ],
    "gold_answer": "Mild intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00868",
    "question": "What is associated with Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 1?",
    "seeds": [
      "Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 1"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00869",
    "question": "What is associated with Global developmental delay-visual anomalies-progressive cerebellar atrophy-truncal hypotonia syndrome?",
    "seeds": [
      "Global developmental delay-visual anomalies-progressive cerebellar atrophy-truncal hypotonia syndrome"
    ],
    "gold_answer": "Secondary microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00870",
    "question": "What is associated with Lymphedema-Distichiasis syndrome?",
    "seeds": [
      "Lymphedema-Distichiasis syndrome"
    ],
    "gold_answer": "JAG1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00871",
    "question": "What phenotype is associated with Deafness-intellectual disability syndrome, Martin-Probst type?",
    "seeds": [
      "Deafness-intellectual disability syndrome, Martin-Probst type"
    ],
    "gold_answer": "Vesicovaginal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00872",
    "question": "What is associated with Decreased CSF 5-hydroxyindolacetic acid concentration?",
    "seeds": [
      "Decreased CSF 5-hydroxyindolacetic acid concentration"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00873",
    "question": "What is associated with LIPE-related familial partial lipodystrophy?",
    "seeds": [
      "LIPE-related familial partial lipodystrophy"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00874",
    "question": "What is associated with Spinal muscular atrophy, lower extremity-predominant, 2, autosomaldominant?",
    "seeds": [
      "Spinal muscular atrophy, lower extremity-predominant, 2, autosomaldominant"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00875",
    "question": "What is associated with Idiopathic pulmonary hemosiderosis?",
    "seeds": [
      "Idiopathic pulmonary hemosiderosis"
    ],
    "gold_answer": "Acute phase response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00876",
    "question": "What is associated with Overriding atrioventricular valve?",
    "seeds": [
      "Overriding atrioventricular valve"
    ],
    "gold_answer": "Abnormal connection of the cardiac segments",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00877",
    "question": "What is associated with Positive respiratory tract infectious agent test?",
    "seeds": [
      "Positive respiratory tract infectious agent test"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00878",
    "question": "What is associated with Pectus carinatum?",
    "seeds": [
      "Pectus carinatum"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00879",
    "question": "What phenotype is associated with Deafness, autosomal dominant nonsyndromic sensorineural 13?",
    "seeds": [
      "Deafness, autosomal dominant nonsyndromic sensorineural 13"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00880",
    "question": "What is associated with Non-convulsive status epilepticus without coma?",
    "seeds": [
      "Non-convulsive status epilepticus without coma"
    ],
    "gold_answer": "Status epilepticus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00881",
    "question": "What is associated with Neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity?",
    "seeds": [
      "Neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00882",
    "question": "What is associated with Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level?",
    "seeds": [
      "Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level"
    ],
    "gold_answer": "Abnormal urinary purine level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00883",
    "question": "What is associated with Morgagni diaphragmatic hernia?",
    "seeds": [
      "Morgagni diaphragmatic hernia"
    ],
    "gold_answer": "Congenital diaphragmatic hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00884",
    "question": "What phenotype is associated with Platyspondylic dysplasia, Torrance type?",
    "seeds": [
      "Platyspondylic dysplasia, Torrance type"
    ],
    "gold_answer": "Depressed nasal bridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00885",
    "question": "What is associated with Abnormality nasal septum cartilage morphology?",
    "seeds": [
      "Abnormality nasal septum cartilage morphology"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00886",
    "question": "What is associated with Irregular olecranon?",
    "seeds": [
      "Irregular olecranon"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00887",
    "question": "What is associated with Scalp nodule?",
    "seeds": [
      "Scalp nodule"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00888",
    "question": "What is associated with Atelosteogenesis type I?",
    "seeds": [
      "Atelosteogenesis type I"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00889",
    "question": "What phenotype is associated with Lobar holoprosencephaly?",
    "seeds": [
      "Lobar holoprosencephaly"
    ],
    "gold_answer": "Flat occiput",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00890",
    "question": "What phenotype is associated with Commissural lip pits?",
    "seeds": [
      "Commissural lip pits"
    ],
    "gold_answer": "Commissural lip pit",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00891",
    "question": "What phenotype is associated with Autoimmune polyendocrine syndrome, type II?",
    "seeds": [
      "Autoimmune polyendocrine syndrome, type II"
    ],
    "gold_answer": "Abnormality of the endocardium",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00892",
    "question": "What phenotype is associated with Olmsted syndrome 1?",
    "seeds": [
      "Olmsted syndrome 1"
    ],
    "gold_answer": "Abnormality of the nail",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00893",
    "question": "What is associated with Pyelonephritis?",
    "seeds": [
      "Pyelonephritis"
    ],
    "gold_answer": "Nephritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00894",
    "question": "What is associated with Trident acetabulum?",
    "seeds": [
      "Trident acetabulum"
    ],
    "gold_answer": "Abnormal hip joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00895",
    "question": "What is associated with Alopecia, androgenetic, 1?",
    "seeds": [
      "Alopecia, androgenetic, 1"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00896",
    "question": "What is associated with Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency?",
    "seeds": [
      "Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00897",
    "question": "What is associated with Abnormal liver sonography?",
    "seeds": [
      "Abnormal liver sonography"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00898",
    "question": "What is associated with Hypoplastic fifth toenail?",
    "seeds": [
      "Hypoplastic fifth toenail"
    ],
    "gold_answer": "Hypoplastic toenails",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00899",
    "question": "What is associated with Absent epiphysis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Absent epiphysis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal fifth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00900",
    "question": "What is associated with Body ache?",
    "seeds": [
      "Body ache"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00901",
    "question": "What phenotype is associated with Plasminogen activator inhibitor-1 deficiency?",
    "seeds": [
      "Plasminogen activator inhibitor-1 deficiency"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00902",
    "question": "What phenotype is associated with Long QT syndrome 6?",
    "seeds": [
      "Long QT syndrome 6"
    ],
    "gold_answer": "Torsade de pointes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00903",
    "question": "What is associated with Reduced liver carboxylesterase 1 activity?",
    "seeds": [
      "Reduced liver carboxylesterase 1 activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00904",
    "question": "What is associated with Familial clubfoot due to 17q23.1q23.2 microduplication?",
    "seeds": [
      "Familial clubfoot due to 17q23.1q23.2 microduplication"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00905",
    "question": "What is associated with Impulsivity?",
    "seeds": [
      "Impulsivity"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00906",
    "question": "What is associated with Shoulder labrum tear?",
    "seeds": [
      "Shoulder labrum tear"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00907",
    "question": "What phenotype is associated with Kimura disease?",
    "seeds": [
      "Kimura disease"
    ],
    "gold_answer": "Lymphadenopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00908",
    "question": "What phenotype is associated with Pontocerebellar hypoplasia, type 2B?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 2B"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00909",
    "question": "What is associated with Broad fingertip?",
    "seeds": [
      "Broad fingertip"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00910",
    "question": "What is associated with Renal medullary hyperechogenicity?",
    "seeds": [
      "Renal medullary hyperechogenicity"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00911",
    "question": "What phenotype is associated with Palmoplantar keratoderma, Nagashima type?",
    "seeds": [
      "Palmoplantar keratoderma, Nagashima type"
    ],
    "gold_answer": "Hyperhidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00912",
    "question": "What is associated with Severe neurodevelopmental disorder with feeding difficulties-stereotypic hand movement-bilateral cataract?",
    "seeds": [
      "Severe neurodevelopmental disorder with feeding difficulties-stereotypic hand movement-bilateral cataract"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00913",
    "question": "What is associated with Congenital nonbullous ichthyosiform erythroderma?",
    "seeds": [
      "Congenital nonbullous ichthyosiform erythroderma"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00914",
    "question": "What is associated with Jaberi-Elahi syndrome?",
    "seeds": [
      "Jaberi-Elahi syndrome"
    ],
    "gold_answer": "Interphalangeal joint contracture of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00915",
    "question": "What phenotype is associated with Hennekam lymphangiectasia-lymphedema syndrome 2?",
    "seeds": [
      "Hennekam lymphangiectasia-lymphedema syndrome 2"
    ],
    "gold_answer": "Ventricular septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00916",
    "question": "What is associated with Type III truncus arteriosus?",
    "seeds": [
      "Type III truncus arteriosus"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00917",
    "question": "What phenotype is associated with Terminal osseous dysplasia?",
    "seeds": [
      "Terminal osseous dysplasia"
    ],
    "gold_answer": "Epicanthus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00918",
    "question": "What is associated with Decreased pineal volume?",
    "seeds": [
      "Decreased pineal volume"
    ],
    "gold_answer": "Abnormal pineal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00919",
    "question": "What is associated with Ductal carcinoma in situ?",
    "seeds": [
      "Ductal carcinoma in situ"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00920",
    "question": "What phenotype is associated with Epilepsy, familial focal, with variable foci?",
    "seeds": [
      "Epilepsy, familial focal, with variable foci"
    ],
    "gold_answer": "Focal cortical dysplasia type IIa",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00921",
    "question": "What is associated with Agenesis of the diaphragm?",
    "seeds": [
      "Agenesis of the diaphragm"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the diaphragm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00922",
    "question": "What is associated with Nail disorder, nonsyndromic congenital, 5?",
    "seeds": [
      "Nail disorder, nonsyndromic congenital, 5"
    ],
    "gold_answer": "Palmar hyperhidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00923",
    "question": "What is associated with Isolated generalized anhidrosis with normal sweat glands?",
    "seeds": [
      "Isolated generalized anhidrosis with normal sweat glands"
    ],
    "gold_answer": "ITPR2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_test_00924",
    "question": "What is associated with Pseudoepiphysis of the proximal phalanx of the hallux?",
    "seeds": [
      "Pseudoepiphysis of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Pseudoepiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00925",
    "question": "What phenotype is associated with Myopathy, mitochondrial, lethal infantile?",
    "seeds": [
      "Myopathy, mitochondrial, lethal infantile"
    ],
    "gold_answer": "Myopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00926",
    "question": "What is associated with Koebner Phenomenon?",
    "seeds": [
      "Koebner Phenomenon"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00927",
    "question": "What is associated with Vulvar adenocarcinoma?",
    "seeds": [
      "Vulvar adenocarcinoma"
    ],
    "gold_answer": "Vulvar neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00928",
    "question": "What is associated with Chordoma?",
    "seeds": [
      "Chordoma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00929",
    "question": "What is associated with Abnormal cecum morphology?",
    "seeds": [
      "Abnormal cecum morphology"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00930",
    "question": "What phenotype is associated with Sandhoff disease, infantile form?",
    "seeds": [
      "Sandhoff disease, infantile form"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00931",
    "question": "What is associated with Increased fecal calprotectin level?",
    "seeds": [
      "Increased fecal calprotectin level"
    ],
    "gold_answer": "Abnormal stool composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00932",
    "question": "What is associated with Triangular shaped phalanges of the 2nd toe?",
    "seeds": [
      "Triangular shaped phalanges of the 2nd toe"
    ],
    "gold_answer": "Triangular shaped phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00933",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 13?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 13"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00934",
    "question": "What is associated with Aicardi-Goutieres syndrome 7?",
    "seeds": [
      "Aicardi-Goutieres syndrome 7"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00935",
    "question": "What is associated with Syndromic X-linked intellectual disability 7?",
    "seeds": [
      "Syndromic X-linked intellectual disability 7"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00936",
    "question": "What is associated with Underdeveloped superior crus of antihelix?",
    "seeds": [
      "Underdeveloped superior crus of antihelix"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00937",
    "question": "What is associated with Abnormal transferrin saturation?",
    "seeds": [
      "Abnormal transferrin saturation"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00938",
    "question": "What phenotype is associated with Spermatogenic failure 15?",
    "seeds": [
      "Spermatogenic failure 15"
    ],
    "gold_answer": "Male infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00939",
    "question": "What is associated with Abnormal circulating aromatic amino acid concentration?",
    "seeds": [
      "Abnormal circulating aromatic amino acid concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00940",
    "question": "What is associated with Scanning speech?",
    "seeds": [
      "Scanning speech"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00941",
    "question": "What phenotype is associated with Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia?",
    "seeds": [
      "Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00942",
    "question": "What is associated with Increased PIVKA-II?",
    "seeds": [
      "Increased PIVKA-II"
    ],
    "gold_answer": "Abnormality of vitamin metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00943",
    "question": "What is associated with Sydenham chorea?",
    "seeds": [
      "Sydenham chorea"
    ],
    "gold_answer": "Abnormal endocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00944",
    "question": "What is associated with Anorchism?",
    "seeds": [
      "Anorchism"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00945",
    "question": "What is associated with Webbed neck?",
    "seeds": [
      "Webbed neck"
    ],
    "gold_answer": "Abnormal neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00946",
    "question": "What phenotype is associated with Iris pigment epithelium anomalies?",
    "seeds": [
      "Iris pigment epithelium anomalies"
    ],
    "gold_answer": "Iris cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00947",
    "question": "What is associated with GM2-gangliosidosis, AB variant?",
    "seeds": [
      "GM2-gangliosidosis, AB variant"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00948",
    "question": "What is associated with Congenital muscular dystrophy with intellectual disability?",
    "seeds": [
      "Congenital muscular dystrophy with intellectual disability"
    ],
    "gold_answer": "POMT1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_00949",
    "question": "What is associated with Decreased circulating level of specific antibody?",
    "seeds": [
      "Decreased circulating level of specific antibody"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00950",
    "question": "What is associated with Incyclophoria?",
    "seeds": [
      "Incyclophoria"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00951",
    "question": "What is associated with Deafness, autosomal recessive 97?",
    "seeds": [
      "Deafness, autosomal recessive 97"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00952",
    "question": "What is associated with Split nail?",
    "seeds": [
      "Split nail"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00953",
    "question": "What is associated with Tarsal osteovalgus?",
    "seeds": [
      "Tarsal osteovalgus"
    ],
    "gold_answer": "Abnormal talus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00954",
    "question": "What is associated with Maternal thrombophilia?",
    "seeds": [
      "Maternal thrombophilia"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00955",
    "question": "What is associated with Atrophy/Degeneration affecting the brainstem?",
    "seeds": [
      "Atrophy/Degeneration affecting the brainstem"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00956",
    "question": "What is associated with Positive CSF varicella zoster virus nucleic acid test?",
    "seeds": [
      "Positive CSF varicella zoster virus nucleic acid test"
    ],
    "gold_answer": "Positive CSF infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00957",
    "question": "What is associated with Positive CSF JC-virus nucleic acid test?",
    "seeds": [
      "Positive CSF JC-virus nucleic acid test"
    ],
    "gold_answer": "Positive CSF nucleic acid pathogen test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00958",
    "question": "What is associated with Increased scrotal rugation?",
    "seeds": [
      "Increased scrotal rugation"
    ],
    "gold_answer": "Abnormal scrotal rugation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00959",
    "question": "What phenotype is associated with 49,XXXXY syndrome?",
    "seeds": [
      "49,XXXXY syndrome"
    ],
    "gold_answer": "Carious teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00960",
    "question": "What is associated with Papillomatosis, familial cutaneous?",
    "seeds": [
      "Papillomatosis, familial cutaneous"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00961",
    "question": "What is associated with Ankle hypermobility?",
    "seeds": [
      "Ankle hypermobility"
    ],
    "gold_answer": "Joint hypermobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00962",
    "question": "What is associated with Diamond-Blackfan anemia-like?",
    "seeds": [
      "Diamond-Blackfan anemia-like"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00963",
    "question": "What is associated with Irregular epiphysis of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Irregular epiphysis of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Irregular epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00964",
    "question": "What is associated with Small epiphysis of the distal phalanx of the hallux?",
    "seeds": [
      "Small epiphysis of the distal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00965",
    "question": "What is associated with Fractured bone of jaw?",
    "seeds": [
      "Fractured bone of jaw"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00966",
    "question": "What is associated with Decreased circulating UDP glucose-4-epimerase concentration?",
    "seeds": [
      "Decreased circulating UDP glucose-4-epimerase concentration"
    ],
    "gold_answer": "Abnormal circulating UDP glucose-4-epimerase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00967",
    "question": "What is associated with Reflex seizure?",
    "seeds": [
      "Reflex seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00968",
    "question": "What is associated with Elevated circulating acylcarnitine concentration?",
    "seeds": [
      "Elevated circulating acylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating fatty-acid anion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00969",
    "question": "What phenotype is associated with Amyloidosis, hereditary systemic 3?",
    "seeds": [
      "Amyloidosis, hereditary systemic 3"
    ],
    "gold_answer": "Cardiomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00970",
    "question": "What is associated with Pigmentary retinopathy?",
    "seeds": [
      "Pigmentary retinopathy"
    ],
    "gold_answer": "Abnormal retinal pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00971",
    "question": "What phenotype is associated with Narcolepsy type 2?",
    "seeds": [
      "Narcolepsy type 2"
    ],
    "gold_answer": "Insomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00972",
    "question": "What is associated with Peroxisome biogenesis disorder 11B?",
    "seeds": [
      "Peroxisome biogenesis disorder 11B"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00973",
    "question": "What is associated with Fragmentation of the epiphyses of the 5th toe?",
    "seeds": [
      "Fragmentation of the epiphyses of the 5th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00974",
    "question": "What phenotype is associated with Peroxisome biogenesis disorder 2A (Zellweger)?",
    "seeds": [
      "Peroxisome biogenesis disorder 2A (Zellweger)"
    ],
    "gold_answer": "Upslanted palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00975",
    "question": "What is associated with Irregularly shaped sperm tail?",
    "seeds": [
      "Irregularly shaped sperm tail"
    ],
    "gold_answer": "Abnormal sperm tail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00976",
    "question": "What is associated with Nail disorder, nonsyndromic congenital, 5?",
    "seeds": [
      "Nail disorder, nonsyndromic congenital, 5"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00977",
    "question": "What is associated with Isolated fibular hemimelia?",
    "seeds": [
      "Isolated fibular hemimelia"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00978",
    "question": "What is associated with Cortical thinning of hand bones?",
    "seeds": [
      "Cortical thinning of hand bones"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00979",
    "question": "What is associated with Abnormal brain positron emission tomography?",
    "seeds": [
      "Abnormal brain positron emission tomography"
    ],
    "gold_answer": "Brain imaging abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00980",
    "question": "What is associated with AICA-ribosiduria due to ATIC deficiency?",
    "seeds": [
      "AICA-ribosiduria due to ATIC deficiency"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00981",
    "question": "What phenotype is associated with El Hayek-Chahrour neurodevelopmental syndrome?",
    "seeds": [
      "El Hayek-Chahrour neurodevelopmental syndrome"
    ],
    "gold_answer": "Low-set ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00982",
    "question": "What is associated with Dandy-Walker malformation?",
    "seeds": [
      "Dandy-Walker malformation"
    ],
    "gold_answer": "Cerebellar vermis hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00983",
    "question": "What is associated with Cardiac sarcoma?",
    "seeds": [
      "Cardiac sarcoma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00984",
    "question": "What is associated with Diamond-Blackfan anemia 16?",
    "seeds": [
      "Diamond-Blackfan anemia 16"
    ],
    "gold_answer": "Abnormal cardiac atrium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00985",
    "question": "What is associated with Decreased circulating hydroxyproline concentration?",
    "seeds": [
      "Decreased circulating hydroxyproline concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00986",
    "question": "What phenotype is associated with Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 2?",
    "seeds": [
      "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 2"
    ],
    "gold_answer": "Ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00987",
    "question": "What is associated with Abnormal erythrocyte metabolite concentration?",
    "seeds": [
      "Abnormal erythrocyte metabolite concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00988",
    "question": "What is associated with Localized along nerve distribution?",
    "seeds": [
      "Localized along nerve distribution"
    ],
    "gold_answer": "Localized",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00989",
    "question": "What is associated with Left axis deviation?",
    "seeds": [
      "Left axis deviation"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00990",
    "question": "What is associated with Metabolic ketoacidosis?",
    "seeds": [
      "Metabolic ketoacidosis"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00991",
    "question": "What is associated with Abnormal cerebellar vermis morphology?",
    "seeds": [
      "Abnormal cerebellar vermis morphology"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00992",
    "question": "What is associated with Anti-factor X antibody positivity?",
    "seeds": [
      "Anti-factor X antibody positivity"
    ],
    "gold_answer": "Anti-coagulation factor antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00993",
    "question": "What is associated with Tetanus?",
    "seeds": [
      "Tetanus"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00994",
    "question": "What is associated with Broad proximal phalanx of the 5th toe?",
    "seeds": [
      "Broad proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00995",
    "question": "What is associated with Fractured distal epiphysis of distal phalanx of manual digit 1?",
    "seeds": [
      "Fractured distal epiphysis of distal phalanx of manual digit 1"
    ],
    "gold_answer": "Fragmentation of the epiphyses of the distal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00996",
    "question": "What is associated with Fascicular left ventricular tachycardia?",
    "seeds": [
      "Fascicular left ventricular tachycardia"
    ],
    "gold_answer": "Ventricular tachycardia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00997",
    "question": "What phenotype is associated with Stickler syndrome, type I?",
    "seeds": [
      "Stickler syndrome, type I"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_00998",
    "question": "What is associated with Unbalanced atrioventricular canal defect?",
    "seeds": [
      "Unbalanced atrioventricular canal defect"
    ],
    "gold_answer": "Abnormal cardiac septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_00999",
    "question": "What is associated with Gingival calcification?",
    "seeds": [
      "Gingival calcification"
    ],
    "gold_answer": "Abnormality of the gingiva",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01000",
    "question": "What is associated with Immunodeficiency 98 with autoinflammation, X-linked?",
    "seeds": [
      "Immunodeficiency 98 with autoinflammation, X-linked"
    ],
    "gold_answer": "Chronic mucocutaneous candidiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01001",
    "question": "What is associated with Visual agnosia?",
    "seeds": [
      "Visual agnosia"
    ],
    "gold_answer": "Disturbed sensory perception",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01002",
    "question": "What is associated with Pseudoepiphysis of the middle phalanx of the 5th toe?",
    "seeds": [
      "Pseudoepiphysis of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01003",
    "question": "What is associated with Basal encephalocele?",
    "seeds": [
      "Basal encephalocele"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01004",
    "question": "What phenotype is associated with Thymic neuroendocrine tumor?",
    "seeds": [
      "Thymic neuroendocrine tumor"
    ],
    "gold_answer": "Increased circulating cortisol level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01005",
    "question": "What is associated with Abnormal affect?",
    "seeds": [
      "Abnormal affect"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01006",
    "question": "What is associated with Abnormal bursal fluid morphology?",
    "seeds": [
      "Abnormal bursal fluid morphology"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01007",
    "question": "What is associated with Mucopolysacchariduria?",
    "seeds": [
      "Mucopolysacchariduria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01008",
    "question": "What phenotype is associated with Neurofibroma?",
    "seeds": [
      "Neurofibroma"
    ],
    "gold_answer": "Abnormal cranial nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01009",
    "question": "What is associated with Dental crowding?",
    "seeds": [
      "Dental crowding"
    ],
    "gold_answer": "Tooth malposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01010",
    "question": "What is associated with Paraganglioma?",
    "seeds": [
      "Paraganglioma"
    ],
    "gold_answer": "Neoplasm of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01011",
    "question": "What is associated with Abnormal doll's eye reflex?",
    "seeds": [
      "Abnormal doll's eye reflex"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01012",
    "question": "What is associated with Pulmonary fibrosis?",
    "seeds": [
      "Pulmonary fibrosis"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01013",
    "question": "What is associated with Partial duplication of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Partial duplication of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Partial duplication of phalanx of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01014",
    "question": "What is associated with Deafness, autosomal dominant 79?",
    "seeds": [
      "Deafness, autosomal dominant 79"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01015",
    "question": "What is associated with Subacute cutaneous lupus erythematosus?",
    "seeds": [
      "Subacute cutaneous lupus erythematosus"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01016",
    "question": "What is associated with 14q11.2 microdeletion syndrome?",
    "seeds": [
      "14q11.2 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01017",
    "question": "What is associated with Diplopia?",
    "seeds": [
      "Diplopia"
    ],
    "gold_answer": "Abnormality of binocular vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01018",
    "question": "What is associated with Hypoplastic aortic arch?",
    "seeds": [
      "Hypoplastic aortic arch"
    ],
    "gold_answer": "Abnormal aortic arch morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01019",
    "question": "What phenotype is associated with Trichodental dysplasia?",
    "seeds": [
      "Trichodental dysplasia"
    ],
    "gold_answer": "Fine hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01020",
    "question": "What is associated with Abnormal eyelid movement?",
    "seeds": [
      "Abnormal eyelid movement"
    ],
    "gold_answer": "Abnormal eyelid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01021",
    "question": "What is associated with Narrow vertebral interpedicular distance?",
    "seeds": [
      "Narrow vertebral interpedicular distance"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01022",
    "question": "What phenotype is associated with Spondyloarthropathy, susceptibility to, 2?",
    "seeds": [
      "Spondyloarthropathy, susceptibility to, 2"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01023",
    "question": "What is associated with Elevated circulating apolipoprotein A-IV concentration?",
    "seeds": [
      "Elevated circulating apolipoprotein A-IV concentration"
    ],
    "gold_answer": "Increased circulating apolipoprotein circulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01024",
    "question": "What is associated with Spinocerebellar ataxia 25?",
    "seeds": [
      "Spinocerebellar ataxia 25"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01025",
    "question": "What is associated with Yellow subcutaneous tissue covered by thin, scaly skin?",
    "seeds": [
      "Yellow subcutaneous tissue covered by thin, scaly skin"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01026",
    "question": "What is associated with Derealization?",
    "seeds": [
      "Derealization"
    ],
    "gold_answer": "Abnormal perceptual state",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01027",
    "question": "What is associated with Storage pool platelet disease?",
    "seeds": [
      "Storage pool platelet disease"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01028",
    "question": "What is associated with Focal facial dermal dysplasia type III?",
    "seeds": [
      "Focal facial dermal dysplasia type III"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01029",
    "question": "What is associated with Elevated CSF N-carbamyl-beta-aminoisobutyric acid concentration?",
    "seeds": [
      "Elevated CSF N-carbamyl-beta-aminoisobutyric acid concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01030",
    "question": "What is associated with Decreased CD8+ T cell degranulation?",
    "seeds": [
      "Decreased CD8+ T cell degranulation"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01031",
    "question": "What is associated with Diffuse spongiform leukoencephalopathy?",
    "seeds": [
      "Diffuse spongiform leukoencephalopathy"
    ],
    "gold_answer": "Leukoencephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01032",
    "question": "What is associated with Religious delusion?",
    "seeds": [
      "Religious delusion"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01033",
    "question": "What is associated with Deafness, progressive, with stapes fixation?",
    "seeds": [
      "Deafness, progressive, with stapes fixation"
    ],
    "gold_answer": "Abnormal stapes morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01034",
    "question": "What is associated with Increased large lymphocytes in lymph node?",
    "seeds": [
      "Increased large lymphocytes in lymph node"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01035",
    "question": "What is associated with Lip tremor?",
    "seeds": [
      "Lip tremor"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01036",
    "question": "What is associated with Bitemporal hemianopia?",
    "seeds": [
      "Bitemporal hemianopia"
    ],
    "gold_answer": "Hemianopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01037",
    "question": "What is associated with Dyspareunia?",
    "seeds": [
      "Dyspareunia"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01038",
    "question": "What is associated with Heart and brain malformation syndrome?",
    "seeds": [
      "Heart and brain malformation syndrome"
    ],
    "gold_answer": "Abnormal cardiac septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01039",
    "question": "What is associated with Neurodevelopmental disorder with hypotonia, poor growth, dysmorphic facies, and agammaglobulinemia?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia, poor growth, dysmorphic facies, and agammaglobulinemia"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01040",
    "question": "What is associated with Decreased 3-hydroxyisobutyrate dehydrogenase activity?",
    "seeds": [
      "Decreased 3-hydroxyisobutyrate dehydrogenase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01041",
    "question": "What is associated with Esotropia?",
    "seeds": [
      "Esotropia"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01042",
    "question": "What is associated with Dermal atrophy?",
    "seeds": [
      "Dermal atrophy"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01043",
    "question": "What is associated with Rounded epiphyses?",
    "seeds": [
      "Rounded epiphyses"
    ],
    "gold_answer": "Abnormal hand epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01044",
    "question": "What is associated with Type 1 muscle fiber predominance?",
    "seeds": [
      "Type 1 muscle fiber predominance"
    ],
    "gold_answer": "Abnormal muscle fiber-type distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01045",
    "question": "What phenotype is associated with 1p31p32 microdeletion syndrome?",
    "seeds": [
      "1p31p32 microdeletion syndrome"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01046",
    "question": "What is associated with Cellular urinary casts?",
    "seeds": [
      "Cellular urinary casts"
    ],
    "gold_answer": "Cylindruria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01047",
    "question": "What is associated with IRIDA syndrome?",
    "seeds": [
      "IRIDA syndrome"
    ],
    "gold_answer": "Abnormality of iron homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01048",
    "question": "What is associated with Neutropenia, severe congenital, 11, autosomal dominant?",
    "seeds": [
      "Neutropenia, severe congenital, 11, autosomal dominant"
    ],
    "gold_answer": "Abnormal granulocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01049",
    "question": "What is associated with Rectal polyposis?",
    "seeds": [
      "Rectal polyposis"
    ],
    "gold_answer": "Neoplasm of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01050",
    "question": "What is associated with Elevated circulating 17-hydroxyprogesterone concentration?",
    "seeds": [
      "Elevated circulating 17-hydroxyprogesterone concentration"
    ],
    "gold_answer": "Abnormal circulating progesterone level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01051",
    "question": "What is associated with Metaphyseal cupping?",
    "seeds": [
      "Metaphyseal cupping"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01052",
    "question": "What is associated with Enlarged epiphysis of the distal phalanx of the 5th toe?",
    "seeds": [
      "Enlarged epiphysis of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Enlarged epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01053",
    "question": "What is associated with Humeral lytic defects?",
    "seeds": [
      "Humeral lytic defects"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01054",
    "question": "What is associated with Pili bifurcati?",
    "seeds": [
      "Pili bifurcati"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01055",
    "question": "What phenotype is associated with Hypotrichosis simplex of the scalp?",
    "seeds": [
      "Hypotrichosis simplex of the scalp"
    ],
    "gold_answer": "Hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01056",
    "question": "What is associated with Cephalohematoma?",
    "seeds": [
      "Cephalohematoma"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01057",
    "question": "What is associated with Pseudoepiphysis of the distal phalanx of the 5th toe?",
    "seeds": [
      "Pseudoepiphysis of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01058",
    "question": "What is associated with Retinal atrophy?",
    "seeds": [
      "Retinal atrophy"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01059",
    "question": "What is associated with Axial osteomalacia?",
    "seeds": [
      "Axial osteomalacia"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01060",
    "question": "What is associated with Alveolar cell carcinoma?",
    "seeds": [
      "Alveolar cell carcinoma"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01061",
    "question": "What is associated with Deafness, congenital, with vitiligo and achalasia?",
    "seeds": [
      "Deafness, congenital, with vitiligo and achalasia"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01062",
    "question": "What is associated with Mirror movements 3?",
    "seeds": [
      "Mirror movements 3"
    ],
    "gold_answer": "CFAP52",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01063",
    "question": "What is associated with Excessive eye contact?",
    "seeds": [
      "Excessive eye contact"
    ],
    "gold_answer": "Abnormal nonverbal communicative behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01064",
    "question": "What is associated with Neurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiency?",
    "seeds": [
      "Neurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiency"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01065",
    "question": "What is associated with Partial absence of foot?",
    "seeds": [
      "Partial absence of foot"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01066",
    "question": "What is associated with Atrophy/Degeneration involving the spinal cord?",
    "seeds": [
      "Atrophy/Degeneration involving the spinal cord"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01067",
    "question": "What is associated with Neurodevelopmental disorder with hypotonia, seizures, and absent language?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia, seizures, and absent language"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01068",
    "question": "What is associated with Prostaglandin E1 exposure?",
    "seeds": [
      "Prostaglandin E1 exposure"
    ],
    "gold_answer": "Medication history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01069",
    "question": "What is associated with Osteoporotic femoral neck?",
    "seeds": [
      "Osteoporotic femoral neck"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01070",
    "question": "What is associated with Renal failure, progressive, with hypertension?",
    "seeds": [
      "Renal failure, progressive, with hypertension"
    ],
    "gold_answer": "Hematuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01071",
    "question": "What is associated with Cystic nephroma?",
    "seeds": [
      "Cystic nephroma"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01072",
    "question": "What is associated with Increased circulating myristoleate level?",
    "seeds": [
      "Increased circulating myristoleate level"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01073",
    "question": "What is associated with Myelodysplasia?",
    "seeds": [
      "Myelodysplasia"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01074",
    "question": "What is associated with Mechanical ileus?",
    "seeds": [
      "Mechanical ileus"
    ],
    "gold_answer": "Ileus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01075",
    "question": "What is associated with Aplasia of the fovea?",
    "seeds": [
      "Aplasia of the fovea"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the fovea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01076",
    "question": "What phenotype is associated with Arachnoiditis?",
    "seeds": [
      "Arachnoiditis"
    ],
    "gold_answer": "Paresthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01077",
    "question": "What is associated with Oculoectodermal syndrome?",
    "seeds": [
      "Oculoectodermal syndrome"
    ],
    "gold_answer": "Dysregulated negative emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01078",
    "question": "What is associated with Positive respiratory tract infectious agent test?",
    "seeds": [
      "Positive respiratory tract infectious agent test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01079",
    "question": "What is associated with Tapered toe?",
    "seeds": [
      "Tapered toe"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01080",
    "question": "What is associated with Osteolytic defects of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Osteolytic defects of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal third toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01081",
    "question": "What is associated with Sonographic non-visualized fetal bladder?",
    "seeds": [
      "Sonographic non-visualized fetal bladder"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01082",
    "question": "What is associated with Cylindroma?",
    "seeds": [
      "Cylindroma"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01083",
    "question": "What is associated with Pointed ulna?",
    "seeds": [
      "Pointed ulna"
    ],
    "gold_answer": "Abnormal morphology of ulna",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01084",
    "question": "What phenotype is associated with Wolcott-Rallison syndrome?",
    "seeds": [
      "Wolcott-Rallison syndrome"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01085",
    "question": "What is associated with Abnormal cry?",
    "seeds": [
      "Abnormal cry"
    ],
    "gold_answer": "Abnormality of the voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01086",
    "question": "What is associated with Tympanic membrane bulging?",
    "seeds": [
      "Tympanic membrane bulging"
    ],
    "gold_answer": "Abnormal tympanic membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01087",
    "question": "What is associated with Focal impaired awareness autonomic seizure with erection?",
    "seeds": [
      "Focal impaired awareness autonomic seizure with erection"
    ],
    "gold_answer": "Focal impaired awareness autonomic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01088",
    "question": "What is associated with Alpha-B crystallin-related late-onset myopathy?",
    "seeds": [
      "Alpha-B crystallin-related late-onset myopathy"
    ],
    "gold_answer": "CRYAB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01089",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 71, with behavioral abnormalities?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 71, with behavioral abnormalities"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01090",
    "question": "What is associated with Copper accumulation in brain?",
    "seeds": [
      "Copper accumulation in brain"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01091",
    "question": "What is associated with Hypermetric horizontal saccades?",
    "seeds": [
      "Hypermetric horizontal saccades"
    ],
    "gold_answer": "Hypermetric saccades",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01092",
    "question": "What is associated with Hypotonia, infantile, with psychomotor retardation and characteristic facies 1?",
    "seeds": [
      "Hypotonia, infantile, with psychomotor retardation and characteristic facies 1"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01093",
    "question": "What is associated with Immunoglobulin D level in plasma, low?",
    "seeds": [
      "Immunoglobulin D level in plasma, low"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01094",
    "question": "What is associated with Subcortical localization?",
    "seeds": [
      "Subcortical localization"
    ],
    "gold_answer": "Brain localization",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01095",
    "question": "What is associated with Corneal scarring?",
    "seeds": [
      "Corneal scarring"
    ],
    "gold_answer": "Scarring",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01096",
    "question": "What is associated with Schinzel-Giedion midface-retraction syndrome?",
    "seeds": [
      "Schinzel-Giedion midface-retraction syndrome"
    ],
    "gold_answer": "Large fontanelles",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01097",
    "question": "What is associated with HYPERTENSION, DIASTOLIC, RESISTANCE TO?",
    "seeds": [
      "HYPERTENSION, DIASTOLIC, RESISTANCE TO"
    ],
    "gold_answer": "Increased blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01098",
    "question": "What phenotype is associated with Mosaic trisomy 2 syndrome?",
    "seeds": [
      "Mosaic trisomy 2 syndrome"
    ],
    "gold_answer": "Cleft lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01099",
    "question": "What is associated with Distal arthrogryposis type 1?",
    "seeds": [
      "Distal arthrogryposis type 1"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01100",
    "question": "What is associated with Abnormal serum bicarbonate concentration?",
    "seeds": [
      "Abnormal serum bicarbonate concentration"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01101",
    "question": "What phenotype is associated with Autosomal recessive centronuclear myopathy?",
    "seeds": [
      "Autosomal recessive centronuclear myopathy"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01102",
    "question": "What is associated with Duplication of the distal phalanx of the hallux?",
    "seeds": [
      "Duplication of the distal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal distal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01103",
    "question": "What is associated with Arcuate artery lumen cholesterol emboli?",
    "seeds": [
      "Arcuate artery lumen cholesterol emboli"
    ],
    "gold_answer": "Abnormal arcuate artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01104",
    "question": "What is associated with Abnormally low-pitched voice?",
    "seeds": [
      "Abnormally low-pitched voice"
    ],
    "gold_answer": "Abnormal Intonation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01105",
    "question": "What is associated with Abnormal pulmonary interstitial morphology?",
    "seeds": [
      "Abnormal pulmonary interstitial morphology"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01106",
    "question": "What is associated with Abnormal posterior cranial fossa morphology?",
    "seeds": [
      "Abnormal posterior cranial fossa morphology"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01107",
    "question": "What is associated with Circulating immune complexes?",
    "seeds": [
      "Circulating immune complexes"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01108",
    "question": "What is associated with Elevated circulating butyrylcarnitine concentration?",
    "seeds": [
      "Elevated circulating butyrylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01109",
    "question": "What is associated with Positive bloodstream cryptococcus culture?",
    "seeds": [
      "Positive bloodstream cryptococcus culture"
    ],
    "gold_answer": "Fungal bloodstream infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01110",
    "question": "What is associated with Typical absence status epilepticus?",
    "seeds": [
      "Typical absence status epilepticus"
    ],
    "gold_answer": "Non-convulsive status epilepticus without coma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01111",
    "question": "What is associated with Increased CSF citrulline concentration?",
    "seeds": [
      "Increased CSF citrulline concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01112",
    "question": "What is associated with Polyarticular arthropathy?",
    "seeds": [
      "Polyarticular arthropathy"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01113",
    "question": "What is associated with Epidermolysis bullosa simplex, autosomal recessive 2?",
    "seeds": [
      "Epidermolysis bullosa simplex, autosomal recessive 2"
    ],
    "gold_answer": "Scarring",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01114",
    "question": "What is associated with Increased HDL cholesterol concentration?",
    "seeds": [
      "Increased HDL cholesterol concentration"
    ],
    "gold_answer": "Abnormal HDL cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01115",
    "question": "What is associated with Annular pancreas?",
    "seeds": [
      "Annular pancreas"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01116",
    "question": "What phenotype is associated with Li-Ghorgani-Weisz-Hubshman syndrome?",
    "seeds": [
      "Li-Ghorgani-Weisz-Hubshman syndrome"
    ],
    "gold_answer": "Thick vermilion border",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01117",
    "question": "What is associated with Macrovesicular hepatic steatosis?",
    "seeds": [
      "Macrovesicular hepatic steatosis"
    ],
    "gold_answer": "Storage in hepatocytes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01118",
    "question": "What is associated with Perinephric abscess?",
    "seeds": [
      "Perinephric abscess"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01119",
    "question": "What is associated with Abnormality of the epiphysis of the femoral head?",
    "seeds": [
      "Abnormality of the epiphysis of the femoral head"
    ],
    "gold_answer": "Abnormal femoral head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01120",
    "question": "What phenotype is associated with Alpha-mannosidosis, adult form?",
    "seeds": [
      "Alpha-mannosidosis, adult form"
    ],
    "gold_answer": "Hallucinations",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01121",
    "question": "What is associated with Abnormal mast cell morphology?",
    "seeds": [
      "Abnormal mast cell morphology"
    ],
    "gold_answer": "Abnormal granulocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01122",
    "question": "What is associated with CHST3-related skeletal dysplasia?",
    "seeds": [
      "CHST3-related skeletal dysplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the metacarpal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01123",
    "question": "What is associated with Aplasia/hypoplasia of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Aplasia/hypoplasia of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01124",
    "question": "What is associated with Hermansky-Pudlak syndrome due to BLOC-2 deficiency?",
    "seeds": [
      "Hermansky-Pudlak syndrome due to BLOC-2 deficiency"
    ],
    "gold_answer": "HPS5",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01125",
    "question": "What is associated with Abnormal circulating IgG concentration?",
    "seeds": [
      "Abnormal circulating IgG concentration"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01126",
    "question": "What is associated with Absence of the third cerebral ventricle?",
    "seeds": [
      "Absence of the third cerebral ventricle"
    ],
    "gold_answer": "Abnormal cerebral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01127",
    "question": "What is associated with Abnormal posterior periventricular white matter morphology?",
    "seeds": [
      "Abnormal posterior periventricular white matter morphology"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01128",
    "question": "What is associated with Predominant small joint localization?",
    "seeds": [
      "Predominant small joint localization"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01129",
    "question": "What is associated with Tubulointerstitial nephritis?",
    "seeds": [
      "Tubulointerstitial nephritis"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01130",
    "question": "What is associated with RASA1-related capillary malformation-arteriovenous malformation?",
    "seeds": [
      "RASA1-related capillary malformation-arteriovenous malformation"
    ],
    "gold_answer": "RASA1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01131",
    "question": "What is associated with Increased circulating IgA concentration?",
    "seeds": [
      "Increased circulating IgA concentration"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01132",
    "question": "What is associated with Osteoid osteoma?",
    "seeds": [
      "Osteoid osteoma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01133",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 91?",
    "seeds": [
      "Developmental and epileptic encephalopathy 91"
    ],
    "gold_answer": "Hoarse voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01134",
    "question": "What is associated with Mosaic central corneal dystrophy?",
    "seeds": [
      "Mosaic central corneal dystrophy"
    ],
    "gold_answer": "Corneal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01135",
    "question": "What phenotype is associated with Mitochondrial complex II deficiency, nuclear type 3?",
    "seeds": [
      "Mitochondrial complex II deficiency, nuclear type 3"
    ],
    "gold_answer": "Dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01136",
    "question": "What is associated with Cortical radial artery intraluminal organized thrombi?",
    "seeds": [
      "Cortical radial artery intraluminal organized thrombi"
    ],
    "gold_answer": "Abnormal cortical radial artery lumen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01137",
    "question": "What phenotype is associated with Peroxisomal fatty acyl-CoA reductase 1 disorder?",
    "seeds": [
      "Peroxisomal fatty acyl-CoA reductase 1 disorder"
    ],
    "gold_answer": "Coarse facial features",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01138",
    "question": "What is associated with 1-3 finger cutaneous syndactyly?",
    "seeds": [
      "1-3 finger cutaneous syndactyly"
    ],
    "gold_answer": "Syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01139",
    "question": "What is associated with Typified by complete penetrance?",
    "seeds": [
      "Typified by complete penetrance"
    ],
    "gold_answer": "Inheritance qualifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01140",
    "question": "What is associated with Arcuate artery endotheliosis?",
    "seeds": [
      "Arcuate artery endotheliosis"
    ],
    "gold_answer": "Abnormal arcuate artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01141",
    "question": "What phenotype is associated with Transaldolase deficiency?",
    "seeds": [
      "Transaldolase deficiency"
    ],
    "gold_answer": "Short philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01142",
    "question": "What is associated with Aplasia/Hypoplasia of the thumb?",
    "seeds": [
      "Aplasia/Hypoplasia of the thumb"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01143",
    "question": "What is associated with Chronic absent circulating IgD?",
    "seeds": [
      "Chronic absent circulating IgD"
    ],
    "gold_answer": "Abnormal circulating IgD concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01144",
    "question": "What phenotype is associated with Acute monoblastic/monocytic leukemia?",
    "seeds": [
      "Acute monoblastic/monocytic leukemia"
    ],
    "gold_answer": "Acute monocytic leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01145",
    "question": "What is associated with Retinopathy, pericentral pigmentary, dominant?",
    "seeds": [
      "Retinopathy, pericentral pigmentary, dominant"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01146",
    "question": "What is associated with Abnormal second heart sound?",
    "seeds": [
      "Abnormal second heart sound"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01147",
    "question": "What is associated with Abnormality of the proximal fibular epiphysis?",
    "seeds": [
      "Abnormality of the proximal fibular epiphysis"
    ],
    "gold_answer": "Abnormal fibular epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01148",
    "question": "What is associated with Mitochondrial DNA depletion syndrome 6 (hepatocerebral type)?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 6 (hepatocerebral type)"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01149",
    "question": "What is associated with Bartter syndrome, type 3?",
    "seeds": [
      "Bartter syndrome, type 3"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01150",
    "question": "What is associated with Penile hypospadias?",
    "seeds": [
      "Penile hypospadias"
    ],
    "gold_answer": "Abnormal male urethral meatus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01151",
    "question": "What is associated with Inflammatory skin and bowel disease, neonatal, 1?",
    "seeds": [
      "Inflammatory skin and bowel disease, neonatal, 1"
    ],
    "gold_answer": "Abnormal small intestinal mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01152",
    "question": "What is associated with Bullet-shaped middle phalanx of the 4th toe?",
    "seeds": [
      "Bullet-shaped middle phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal fourth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01153",
    "question": "What is associated with Hip adductor weakness?",
    "seeds": [
      "Hip adductor weakness"
    ],
    "gold_answer": "Limb-girdle muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01154",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia, matrilin-3 related?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, matrilin-3 related"
    ],
    "gold_answer": "Abnormal ilium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01155",
    "question": "What is associated with Gaucher disease?",
    "seeds": [
      "Gaucher disease"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01156",
    "question": "What is associated with Glycosylphosphatidylinositol biosynthesis defect 11?",
    "seeds": [
      "Glycosylphosphatidylinositol biosynthesis defect 11"
    ],
    "gold_answer": "Abnormality of upper lip vermillion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01157",
    "question": "What is associated with Corneal dystrophy, posterior polymorphous, 3?",
    "seeds": [
      "Corneal dystrophy, posterior polymorphous, 3"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01158",
    "question": "What phenotype is associated with 2p15p16.1 microdeletion syndrome?",
    "seeds": [
      "2p15p16.1 microdeletion syndrome"
    ],
    "gold_answer": "Hypogonadism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01159",
    "question": "What is associated with Developmental and epileptic encephalopathy 110?",
    "seeds": [
      "Developmental and epileptic encephalopathy 110"
    ],
    "gold_answer": "Apraxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01160",
    "question": "What is associated with Increased CSF albumin concentration?",
    "seeds": [
      "Increased CSF albumin concentration"
    ],
    "gold_answer": "Abnormal CSF albumin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01161",
    "question": "What is associated with Anti-aquaporin 4 antibody positivity?",
    "seeds": [
      "Anti-aquaporin 4 antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01162",
    "question": "What is associated with Hypoplastic male external genitalia?",
    "seeds": [
      "Hypoplastic male external genitalia"
    ],
    "gold_answer": "External genital hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01163",
    "question": "What is associated with Achondroplasia, so-called, and severe combined immunodeficiency?",
    "seeds": [
      "Achondroplasia, so-called, and severe combined immunodeficiency"
    ],
    "gold_answer": "Metaphyseal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01164",
    "question": "What is associated with Increased anti-dairy protein IgE antibody level?",
    "seeds": [
      "Increased anti-dairy protein IgE antibody level"
    ],
    "gold_answer": "Increased circulating specific IgE antibody concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01165",
    "question": "What phenotype is associated with Multiple tumor-associated chromosome region 1?",
    "seeds": [
      "Multiple tumor-associated chromosome region 1"
    ],
    "gold_answer": "Cryptorchidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01166",
    "question": "What is associated with Abnormal lymphocyte count?",
    "seeds": [
      "Abnormal lymphocyte count"
    ],
    "gold_answer": "Abnormal leukocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01167",
    "question": "What phenotype is associated with Mayer-Rokitansky-Küster-Hauser syndrome?",
    "seeds": [
      "Mayer-Rokitansky-Küster-Hauser syndrome"
    ],
    "gold_answer": "Bipolar affective disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01168",
    "question": "What is associated with Blood group O?",
    "seeds": [
      "Blood group O"
    ],
    "gold_answer": "Blood group",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01169",
    "question": "What is associated with Broad phalanges of the 5th finger?",
    "seeds": [
      "Broad phalanges of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01170",
    "question": "What is associated with Palmar telangiectasia?",
    "seeds": [
      "Palmar telangiectasia"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01171",
    "question": "What is associated with Cardioacrofacial dysplasia 1?",
    "seeds": [
      "Cardioacrofacial dysplasia 1"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01172",
    "question": "What is associated with Pancreatic squamous cell carcinoma?",
    "seeds": [
      "Pancreatic squamous cell carcinoma"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01173",
    "question": "What is associated with Abnormal stool urobilinogen concentration?",
    "seeds": [
      "Abnormal stool urobilinogen concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01174",
    "question": "What phenotype is associated with Antiphospholipid syndrome, familial?",
    "seeds": [
      "Antiphospholipid syndrome, familial"
    ],
    "gold_answer": "Scleritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01175",
    "question": "What is associated with Cryptococcal meningitis?",
    "seeds": [
      "Cryptococcal meningitis"
    ],
    "gold_answer": "Meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01176",
    "question": "What is associated with X-linked intellectual disability, Schimke type?",
    "seeds": [
      "X-linked intellectual disability, Schimke type"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01177",
    "question": "What is associated with Increased CSF homovanillic acid concentration?",
    "seeds": [
      "Increased CSF homovanillic acid concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01178",
    "question": "What is associated with Progressive truncal ataxia?",
    "seeds": [
      "Progressive truncal ataxia"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01179",
    "question": "What is associated with Melanoma-Pancreatic cancer syndrome?",
    "seeds": [
      "Melanoma-Pancreatic cancer syndrome"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01180",
    "question": "What is associated with Aplasia/Hypoplasia of the external ear?",
    "seeds": [
      "Aplasia/Hypoplasia of the external ear"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01181",
    "question": "What phenotype is associated with IMINOGLYCINURIA?",
    "seeds": [
      "IMINOGLYCINURIA"
    ],
    "gold_answer": "Hyperglycinuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01182",
    "question": "What is associated with Epiphyseal dysplasia?",
    "seeds": [
      "Epiphyseal dysplasia"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01183",
    "question": "What is associated with Lipoyltransferase 1 deficiency?",
    "seeds": [
      "Lipoyltransferase 1 deficiency"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01184",
    "question": "What is associated with Fragmentation of the epiphysis of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Fragmentation of the epiphysis of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01185",
    "question": "What is associated with Noonan syndrome 7?",
    "seeds": [
      "Noonan syndrome 7"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01186",
    "question": "What is associated with Rachitic rosary?",
    "seeds": [
      "Rachitic rosary"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01187",
    "question": "What is associated with Bullet-shaped distal phalanx of the 2nd toe?",
    "seeds": [
      "Bullet-shaped distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01188",
    "question": "What phenotype is associated with Spermatogenic failure 51?",
    "seeds": [
      "Spermatogenic failure 51"
    ],
    "gold_answer": "Absent sperm flagella",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01189",
    "question": "What is associated with Patchy sclerosis of the distal phalanx of the 5th finger?",
    "seeds": [
      "Patchy sclerosis of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01190",
    "question": "What is associated with Decreased CSF 5-methyltetrahydrofolate concentration?",
    "seeds": [
      "Decreased CSF 5-methyltetrahydrofolate concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01191",
    "question": "What phenotype is associated with Metaphyseal chondrodysplasia, Pena type?",
    "seeds": [
      "Metaphyseal chondrodysplasia, Pena type"
    ],
    "gold_answer": "Metaphyseal chondrodysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01192",
    "question": "What is associated with Abnormal morphology of the proximal phalanx of the hallux?",
    "seeds": [
      "Abnormal morphology of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01193",
    "question": "What is associated with Pancreatic cancer, susceptibility to, 1?",
    "seeds": [
      "Pancreatic cancer, susceptibility to, 1"
    ],
    "gold_answer": "Neoplasm of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01194",
    "question": "What is associated with Combined pre- and post-capillary pulmonary hypertension?",
    "seeds": [
      "Combined pre- and post-capillary pulmonary hypertension"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01195",
    "question": "What is associated with Hyporeflexia of lower limbs?",
    "seeds": [
      "Hyporeflexia of lower limbs"
    ],
    "gold_answer": "Hyporeflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01196",
    "question": "What is associated with Proximal symphalangism?",
    "seeds": [
      "Proximal symphalangism"
    ],
    "gold_answer": "Abnormal elbow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01197",
    "question": "What is associated with Jaberi-Elahi syndrome?",
    "seeds": [
      "Jaberi-Elahi syndrome"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01198",
    "question": "What is associated with Premature ovarian failure 9?",
    "seeds": [
      "Premature ovarian failure 9"
    ],
    "gold_answer": "Abnormal ovarian morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01199",
    "question": "What is associated with Elevated urinary coproporphyrin level?",
    "seeds": [
      "Elevated urinary coproporphyrin level"
    ],
    "gold_answer": "Abnormal urinary organic compound level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01200",
    "question": "What is associated with Anti-cryptococcal antibody positivity?",
    "seeds": [
      "Anti-cryptococcal antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01201",
    "question": "What phenotype is associated with 48,XXXY syndrome?",
    "seeds": [
      "48,XXXY syndrome"
    ],
    "gold_answer": "Vesicovaginal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01202",
    "question": "What is associated with Supranuclear ophthalmoplegia?",
    "seeds": [
      "Supranuclear ophthalmoplegia"
    ],
    "gold_answer": "Ophthalmoplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01203",
    "question": "What is associated with Vesicoureteral reflux 8?",
    "seeds": [
      "Vesicoureteral reflux 8"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01204",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 76?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 76"
    ],
    "gold_answer": "Abnormal nasal tip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01205",
    "question": "What is associated with Cutaneous leiomyosarcoma?",
    "seeds": [
      "Cutaneous leiomyosarcoma"
    ],
    "gold_answer": "Sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01206",
    "question": "What is associated with Undifferentiated pleomorphic sarcoma?",
    "seeds": [
      "Undifferentiated pleomorphic sarcoma"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01207",
    "question": "What is associated with Predominantly lower limb lymphedema?",
    "seeds": [
      "Predominantly lower limb lymphedema"
    ],
    "gold_answer": "Lymphedema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01208",
    "question": "What phenotype is associated with SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 3; SHEP3?",
    "seeds": [
      "SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 3; SHEP3"
    ],
    "gold_answer": "Freckling",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01209",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 63?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 63"
    ],
    "gold_answer": "Craniofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01210",
    "question": "What is associated with Gingival hyperkeratosis?",
    "seeds": [
      "Gingival hyperkeratosis"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01211",
    "question": "What phenotype is associated with Snowflake vitreoretinal degeneration?",
    "seeds": [
      "Snowflake vitreoretinal degeneration"
    ],
    "gold_answer": "Corneal guttata",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01212",
    "question": "What is associated with Pectus excavatum-macrocephaly-dysplastic nails syndrome?",
    "seeds": [
      "Pectus excavatum-macrocephaly-dysplastic nails syndrome"
    ],
    "gold_answer": "Abnormal midface morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01213",
    "question": "What is associated with Spermatogenic failure 53?",
    "seeds": [
      "Spermatogenic failure 53"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01214",
    "question": "What is associated with Cone-shaped epiphyses of the 4th finger?",
    "seeds": [
      "Cone-shaped epiphyses of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01215",
    "question": "What is associated with Perifolliculitis capitis abscedens et suffodiens, familial?",
    "seeds": [
      "Perifolliculitis capitis abscedens et suffodiens, familial"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01216",
    "question": "What is associated with Chest pain described as ripping or tearing?",
    "seeds": [
      "Chest pain described as ripping or tearing"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01217",
    "question": "What is associated with Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome?",
    "seeds": [
      "Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome"
    ],
    "gold_answer": "Abnormal atrioventricular valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01218",
    "question": "What is associated with Abnormal glomerular capillary lumen morphology?",
    "seeds": [
      "Abnormal glomerular capillary lumen morphology"
    ],
    "gold_answer": "Abnormal glomerular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01219",
    "question": "What is associated with Thiamine metabolism dysfunction syndrome 4 (bilateral striatal degenerationand progressive polyneuropathy type)?",
    "seeds": [
      "Thiamine metabolism dysfunction syndrome 4 (bilateral striatal degenerationand progressive polyneuropathy type)"
    ],
    "gold_answer": "Peripheral neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01220",
    "question": "What is associated with Osteopetrosis?",
    "seeds": [
      "Osteopetrosis"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01221",
    "question": "What is associated with Complete duplication of the proximal phalanges of the hand?",
    "seeds": [
      "Complete duplication of the proximal phalanges of the hand"
    ],
    "gold_answer": "Complete duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01222",
    "question": "What is associated with Lissencephaly 5?",
    "seeds": [
      "Lissencephaly 5"
    ],
    "gold_answer": "Abnormal cerebral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01223",
    "question": "What is associated with Abnormal B cell physiology?",
    "seeds": [
      "Abnormal B cell physiology"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01224",
    "question": "What is associated with Leber-like hereditary optic neuropathy, autosomal recessive 2?",
    "seeds": [
      "Leber-like hereditary optic neuropathy, autosomal recessive 2"
    ],
    "gold_answer": "Scotoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01225",
    "question": "What is associated with Small cervical vertebral bodies?",
    "seeds": [
      "Small cervical vertebral bodies"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the vertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01226",
    "question": "What is associated with Multiple small vertebral fractures?",
    "seeds": [
      "Multiple small vertebral fractures"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01227",
    "question": "What is associated with Renal artery duplication?",
    "seeds": [
      "Renal artery duplication"
    ],
    "gold_answer": "Abnormal renal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01228",
    "question": "What is associated with Facial-lingual fasciculations?",
    "seeds": [
      "Facial-lingual fasciculations"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01229",
    "question": "What is associated with Esophageal squamous papilloma?",
    "seeds": [
      "Esophageal squamous papilloma"
    ],
    "gold_answer": "Neoplasm of head and neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01230",
    "question": "What phenotype is associated with CHILD syndrome?",
    "seeds": [
      "CHILD syndrome"
    ],
    "gold_answer": "Short metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01231",
    "question": "What is associated with Adenocarcinoma of the large intestine?",
    "seeds": [
      "Adenocarcinoma of the large intestine"
    ],
    "gold_answer": "Adenocarcinoma of the intestines",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01232",
    "question": "What is associated with Deviation of the thumb?",
    "seeds": [
      "Deviation of the thumb"
    ],
    "gold_answer": "Deviation of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01233",
    "question": "What is associated with Periodic fever?",
    "seeds": [
      "Periodic fever"
    ],
    "gold_answer": "Abnormality of temperature regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01234",
    "question": "What phenotype is associated with Neurodevelopmental disorder, X-linked, with craniofacial abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder, X-linked, with craniofacial abnormalities"
    ],
    "gold_answer": "Encephalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01235",
    "question": "What is associated with Four-vessel umbilical cord?",
    "seeds": [
      "Four-vessel umbilical cord"
    ],
    "gold_answer": "Abnormality of the umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01236",
    "question": "What is associated with Best corrected visual acuity 0.2 LogMAR?",
    "seeds": [
      "Best corrected visual acuity 0.2 LogMAR"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01237",
    "question": "What is associated with Focal lupus nephritis?",
    "seeds": [
      "Focal lupus nephritis"
    ],
    "gold_answer": "Lupus nephritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01238",
    "question": "What is associated with Usher syndrome type 1?",
    "seeds": [
      "Usher syndrome type 1"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01239",
    "question": "What is associated with Abnormal glomerular parietal epithelial cell morphology?",
    "seeds": [
      "Abnormal glomerular parietal epithelial cell morphology"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01240",
    "question": "What is associated with Renal artery atherosclerosis?",
    "seeds": [
      "Renal artery atherosclerosis"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01241",
    "question": "What is associated with Enlarged epiphyses of the toes?",
    "seeds": [
      "Enlarged epiphyses of the toes"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01242",
    "question": "What is associated with Cervical vertebrae, agenesis of?",
    "seeds": [
      "Cervical vertebrae, agenesis of"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01243",
    "question": "What is associated with Time agnosia?",
    "seeds": [
      "Time agnosia"
    ],
    "gold_answer": "Abnormal interpretation of external stimuli",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01244",
    "question": "What is associated with CEDNIK syndrome?",
    "seeds": [
      "CEDNIK syndrome"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01245",
    "question": "What phenotype is associated with Fibrodysplasia ossificans progressiva?",
    "seeds": [
      "Fibrodysplasia ossificans progressiva"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01246",
    "question": "What phenotype is associated with Dystonia with cerebellar atrophy?",
    "seeds": [
      "Dystonia with cerebellar atrophy"
    ],
    "gold_answer": "Cerebellar atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01247",
    "question": "What is associated with Polycystic kidney disease 8?",
    "seeds": [
      "Polycystic kidney disease 8"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01248",
    "question": "What is associated with Fulminant hepatic failure?",
    "seeds": [
      "Fulminant hepatic failure"
    ],
    "gold_answer": "Hepatic failure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01249",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 28?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 28"
    ],
    "gold_answer": "Limb hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01250",
    "question": "What phenotype is associated with Ceroid lipofuscinosis, neuronal, 8, northern epilepsy variant?",
    "seeds": [
      "Ceroid lipofuscinosis, neuronal, 8, northern epilepsy variant"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01251",
    "question": "What is associated with Abnormal circulating eicosanoid concentration?",
    "seeds": [
      "Abnormal circulating eicosanoid concentration"
    ],
    "gold_answer": "Abnormal circulating unsaturated fatty acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01252",
    "question": "What is associated with Radioulnar interosseous membrane tear?",
    "seeds": [
      "Radioulnar interosseous membrane tear"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01253",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2Z?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2Z"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01254",
    "question": "What is associated with Curved distal phalanx of the 4th toe?",
    "seeds": [
      "Curved distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01255",
    "question": "What is associated with Prekallikrein deficiency?",
    "seeds": [
      "Prekallikrein deficiency"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01256",
    "question": "What is associated with Hunter-Mcalpine craniosynostosis syndrome?",
    "seeds": [
      "Hunter-Mcalpine craniosynostosis syndrome"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01257",
    "question": "What is associated with Stomach cancer?",
    "seeds": [
      "Stomach cancer"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01258",
    "question": "What is associated with Achromatopsia?",
    "seeds": [
      "Achromatopsia"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01259",
    "question": "What is associated with Hypoplastic left ventricle?",
    "seeds": [
      "Hypoplastic left ventricle"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01260",
    "question": "What is associated with Abnormal pituitary glycoprotein hormone alpha subunit level?",
    "seeds": [
      "Abnormal pituitary glycoprotein hormone alpha subunit level"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01261",
    "question": "What is associated with Short stature-brachydactyly-obesity-global developmental delay syndrome?",
    "seeds": [
      "Short stature-brachydactyly-obesity-global developmental delay syndrome"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01262",
    "question": "What is associated with Frontal cortical atrophy?",
    "seeds": [
      "Frontal cortical atrophy"
    ],
    "gold_answer": "Cerebral atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01263",
    "question": "What is associated with Wilson sign?",
    "seeds": [
      "Wilson sign"
    ],
    "gold_answer": "Knee pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01264",
    "question": "What is associated with Visceral hallucination?",
    "seeds": [
      "Visceral hallucination"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01265",
    "question": "What is associated with Autism susceptibility 1?",
    "seeds": [
      "Autism susceptibility 1"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01266",
    "question": "What phenotype is associated with Syndactyly type 4?",
    "seeds": [
      "Syndactyly type 4"
    ],
    "gold_answer": "6 metacarpals",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01267",
    "question": "What is associated with Bilateral frontoparietal polymicrogyria?",
    "seeds": [
      "Bilateral frontoparietal polymicrogyria"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01268",
    "question": "What is associated with Thumb hypoplasia grade 1?",
    "seeds": [
      "Thumb hypoplasia grade 1"
    ],
    "gold_answer": "Short thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01269",
    "question": "What phenotype is associated with Silver-Russell syndrome 1?",
    "seeds": [
      "Silver-Russell syndrome 1"
    ],
    "gold_answer": "Short distal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01270",
    "question": "What is associated with Aplasia of the distal phalanx of the 4th toe?",
    "seeds": [
      "Aplasia of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Aplasia of the phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01271",
    "question": "What is associated with Decreased glucose-6-phosphate dehydrogenase level in red blood cells?",
    "seeds": [
      "Decreased glucose-6-phosphate dehydrogenase level in red blood cells"
    ],
    "gold_answer": "Abnormal glucose-6-phosphate dehydrogenase level in red blood cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01272",
    "question": "What is associated with Cleft, median, of upper lip with polyps of facial skin and nasal mucosa?",
    "seeds": [
      "Cleft, median, of upper lip with polyps of facial skin and nasal mucosa"
    ],
    "gold_answer": "Cleft soft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01273",
    "question": "What is associated with Reduced alpha-2-antiplasmin activity?",
    "seeds": [
      "Reduced alpha-2-antiplasmin activity"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01274",
    "question": "What is associated with Abnormal coagulation factor V activity?",
    "seeds": [
      "Abnormal coagulation factor V activity"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01275",
    "question": "What is associated with Atrichia with papular lesions?",
    "seeds": [
      "Atrichia with papular lesions"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01276",
    "question": "What is associated with Abdominal adhesions?",
    "seeds": [
      "Abdominal adhesions"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01277",
    "question": "What is associated with Nephronophthisis 15?",
    "seeds": [
      "Nephronophthisis 15"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01278",
    "question": "What is associated with Inflammatory bowel disease 1, Crohn disease?",
    "seeds": [
      "Inflammatory bowel disease 1, Crohn disease"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01279",
    "question": "What is associated with Nodular inflammatory vasculitis?",
    "seeds": [
      "Nodular inflammatory vasculitis"
    ],
    "gold_answer": "Vasculitis by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01280",
    "question": "What is associated with Deafness, autosomal recessive 45?",
    "seeds": [
      "Deafness, autosomal recessive 45"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01281",
    "question": "What is associated with Renal interstitial mononuclear cell infiltration?",
    "seeds": [
      "Renal interstitial mononuclear cell infiltration"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01282",
    "question": "What is associated with Darier's sign?",
    "seeds": [
      "Darier's sign"
    ],
    "gold_answer": "Urticaria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01283",
    "question": "What phenotype is associated with Trichothiodystrophy 4, nonphotosensitive?",
    "seeds": [
      "Trichothiodystrophy 4, nonphotosensitive"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01284",
    "question": "What is associated with Palmoplantar location?",
    "seeds": [
      "Palmoplantar location"
    ],
    "gold_answer": "Localized",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01285",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 3?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 3"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01286",
    "question": "What is associated with Bleeding disorder, platelet-type, 20?",
    "seeds": [
      "Bleeding disorder, platelet-type, 20"
    ],
    "gold_answer": "Subcutaneous hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01287",
    "question": "What is associated with Positive shoulder apprehension test?",
    "seeds": [
      "Positive shoulder apprehension test"
    ],
    "gold_answer": "Abnormal shoulder physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01288",
    "question": "What is associated with Against the rule astigmatism?",
    "seeds": [
      "Against the rule astigmatism"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01289",
    "question": "What is associated with Retinal arteriolar tortuosity?",
    "seeds": [
      "Retinal arteriolar tortuosity"
    ],
    "gold_answer": "Abnormal retinal arterial/arteriolar morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01290",
    "question": "What is associated with Hamartoma of the eye?",
    "seeds": [
      "Hamartoma of the eye"
    ],
    "gold_answer": "Hamartoma of the orbital region",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01291",
    "question": "What is associated with Deeply set eye?",
    "seeds": [
      "Deeply set eye"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01292",
    "question": "What is associated with Central adrenal insufficiency?",
    "seeds": [
      "Central adrenal insufficiency"
    ],
    "gold_answer": "Abnormality of the adrenal glands",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01293",
    "question": "What is associated with Analbuminemia?",
    "seeds": [
      "Analbuminemia"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01294",
    "question": "What is associated with Congenital disorder of glycosylation, type Iw?",
    "seeds": [
      "Congenital disorder of glycosylation, type Iw"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01295",
    "question": "What is associated with Periodic paralysis?",
    "seeds": [
      "Periodic paralysis"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01296",
    "question": "What is associated with Scrotal hyperpigmentation?",
    "seeds": [
      "Scrotal hyperpigmentation"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01297",
    "question": "What is associated with Aplasia/Hypoplasia of the eyebrow?",
    "seeds": [
      "Aplasia/Hypoplasia of the eyebrow"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01298",
    "question": "What is associated with Patchy sclerosis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Patchy sclerosis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal 3rd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01299",
    "question": "What is associated with Skeletal dysplasia with delayed epiphyseal and carpal bone ossification?",
    "seeds": [
      "Skeletal dysplasia with delayed epiphyseal and carpal bone ossification"
    ],
    "gold_answer": "Short phalanx of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01300",
    "question": "What phenotype is associated with HELLP syndrome?",
    "seeds": [
      "HELLP syndrome"
    ],
    "gold_answer": "Hypertension",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01301",
    "question": "What is associated with Purulent drainage from skin?",
    "seeds": [
      "Purulent drainage from skin"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01302",
    "question": "What is associated with Decreased circulating IgG2 concentration?",
    "seeds": [
      "Decreased circulating IgG2 concentration"
    ],
    "gold_answer": "Decreased circulating IgG subclass concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01303",
    "question": "What phenotype is associated with ALG8-CDG?",
    "seeds": [
      "ALG8-CDG"
    ],
    "gold_answer": "Nonimmune hydrops fetalis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01304",
    "question": "What is associated with Abnormal urine protein level?",
    "seeds": [
      "Abnormal urine protein level"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01305",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 11?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 11"
    ],
    "gold_answer": "Hyperkinetic movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01306",
    "question": "What is associated with Infection-related hemolytic uremic syndrome?",
    "seeds": [
      "Infection-related hemolytic uremic syndrome"
    ],
    "gold_answer": "Retinopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01307",
    "question": "What is associated with Dorsal wrist pain?",
    "seeds": [
      "Dorsal wrist pain"
    ],
    "gold_answer": "Upper limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01308",
    "question": "What is associated with Aplasia of the upper vagina?",
    "seeds": [
      "Aplasia of the upper vagina"
    ],
    "gold_answer": "Abnormal vagina morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01309",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 78?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 78"
    ],
    "gold_answer": "Cerebral visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01310",
    "question": "What is associated with Von Willebrand disease type 1?",
    "seeds": [
      "Von Willebrand disease type 1"
    ],
    "gold_answer": "VWF",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01311",
    "question": "What phenotype is associated with Polymicrogyria, bilateral temporooccipital?",
    "seeds": [
      "Polymicrogyria, bilateral temporooccipital"
    ],
    "gold_answer": "Polymicrogyria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01312",
    "question": "What is associated with Focal aware manual automatism seizure?",
    "seeds": [
      "Focal aware manual automatism seizure"
    ],
    "gold_answer": "Focal aware automatism seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01313",
    "question": "What is associated with Abnormality of the epiphyses of the distal phalanx of finger?",
    "seeds": [
      "Abnormality of the epiphyses of the distal phalanx of finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01314",
    "question": "What is associated with Aniridia?",
    "seeds": [
      "Aniridia"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01315",
    "question": "What is associated with Weak cry?",
    "seeds": [
      "Weak cry"
    ],
    "gold_answer": "Abnormality of the voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01316",
    "question": "What is associated with Reduced erythrocyte inosine triphosphatase activity?",
    "seeds": [
      "Reduced erythrocyte inosine triphosphatase activity"
    ],
    "gold_answer": "Abnormal erythrocyte enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01317",
    "question": "What phenotype is associated with Mismatch repair cancer syndrome 1?",
    "seeds": [
      "Mismatch repair cancer syndrome 1"
    ],
    "gold_answer": "Increased circulating ferritin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01318",
    "question": "What is associated with Neurodevelopmental delay?",
    "seeds": [
      "Neurodevelopmental delay"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01319",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type Icc?",
    "seeds": [
      "Congenital disorder of glycosylation, type Icc"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01320",
    "question": "What is associated with Vertical supranuclear gaze palsy?",
    "seeds": [
      "Vertical supranuclear gaze palsy"
    ],
    "gold_answer": "Supranuclear gaze palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01321",
    "question": "What is associated with Global developmental delay, lung cysts, overgrowth, and wilms tumor?",
    "seeds": [
      "Global developmental delay, lung cysts, overgrowth, and wilms tumor"
    ],
    "gold_answer": "Increased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01322",
    "question": "What is associated with Crumpled humerus?",
    "seeds": [
      "Crumpled humerus"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01323",
    "question": "What is associated with Thick pachygyria?",
    "seeds": [
      "Thick pachygyria"
    ],
    "gold_answer": "Abnormal cortical gyration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01324",
    "question": "What is associated with Double outlet left ventricle?",
    "seeds": [
      "Double outlet left ventricle"
    ],
    "gold_answer": "Dermatological manifestations of systemic disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01325",
    "question": "What is associated with Abnormality of acid-base homeostasis?",
    "seeds": [
      "Abnormality of acid-base homeostasis"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01326",
    "question": "What is associated with Brown pigmentation of the conjunctiva?",
    "seeds": [
      "Brown pigmentation of the conjunctiva"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01327",
    "question": "What is associated with Bracket epiphysis of the proximal phalanx of the hallux?",
    "seeds": [
      "Bracket epiphysis of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Bracket epiphyses of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01328",
    "question": "What is associated with Neonatal bilateral symmetric epileptic spasm?",
    "seeds": [
      "Neonatal bilateral symmetric epileptic spasm"
    ],
    "gold_answer": "Neonatal electro-clinical seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01329",
    "question": "What is associated with Nonspecific interstitial pneumonia?",
    "seeds": [
      "Nonspecific interstitial pneumonia"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01330",
    "question": "What is associated with Complete or near-complete absence of specific antibody response to tetanus vaccine?",
    "seeds": [
      "Complete or near-complete absence of specific antibody response to tetanus vaccine"
    ],
    "gold_answer": "Decreased specific antibody response to vaccination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01331",
    "question": "What is associated with Pulmonary situs inversus?",
    "seeds": [
      "Pulmonary situs inversus"
    ],
    "gold_answer": "Abnormal pulmonary situs morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01332",
    "question": "What is associated with Reduced left ventricular ejection fraction?",
    "seeds": [
      "Reduced left ventricular ejection fraction"
    ],
    "gold_answer": "Left ventricular systolic dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01333",
    "question": "What is associated with Abnormality of the coagulation cascade?",
    "seeds": [
      "Abnormality of the coagulation cascade"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01334",
    "question": "What is associated with Disorganization of the anterior cerebellar vermis?",
    "seeds": [
      "Disorganization of the anterior cerebellar vermis"
    ],
    "gold_answer": "Abnormal cerebellar vermis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01335",
    "question": "What is associated with Protruding coccyx?",
    "seeds": [
      "Protruding coccyx"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01336",
    "question": "What is associated with Spastic paraplegia 90A, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 90A, autosomal dominant"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01337",
    "question": "What is associated with Atypical behavior?",
    "seeds": [
      "Atypical behavior"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01338",
    "question": "What phenotype is associated with Glioma susceptibility 3?",
    "seeds": [
      "Glioma susceptibility 3"
    ],
    "gold_answer": "Astrocytoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01339",
    "question": "What is associated with Ventricular arrhythmia?",
    "seeds": [
      "Ventricular arrhythmia"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01340",
    "question": "What is associated with Triangular epiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Triangular epiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01341",
    "question": "What is associated with Increased glutamine family amino acid level in urine?",
    "seeds": [
      "Increased glutamine family amino acid level in urine"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01342",
    "question": "What is associated with Thyroid hormonogenesis, genetic defect in, 3?",
    "seeds": [
      "Thyroid hormonogenesis, genetic defect in, 3"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01343",
    "question": "What is associated with Elevated circulating succinylacetone concentration?",
    "seeds": [
      "Elevated circulating succinylacetone concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01344",
    "question": "What is associated with Basal ganglia necrosis?",
    "seeds": [
      "Basal ganglia necrosis"
    ],
    "gold_answer": "Abnormal basal ganglia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01345",
    "question": "What is associated with Mandibulofacial dysostosis with ptosis, autosomal dominant?",
    "seeds": [
      "Mandibulofacial dysostosis with ptosis, autosomal dominant"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01346",
    "question": "What is associated with Otopalatodigital syndrome, type I?",
    "seeds": [
      "Otopalatodigital syndrome, type I"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01347",
    "question": "What is associated with Small bowel diverticula?",
    "seeds": [
      "Small bowel diverticula"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01348",
    "question": "What is associated with Tearfulness?",
    "seeds": [
      "Tearfulness"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01349",
    "question": "What is associated with Buphthalmos?",
    "seeds": [
      "Buphthalmos"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01350",
    "question": "What is associated with Dilatation of an abdominal artery?",
    "seeds": [
      "Dilatation of an abdominal artery"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01351",
    "question": "What phenotype is associated with Adult syndrome?",
    "seeds": [
      "Adult syndrome"
    ],
    "gold_answer": "Delayed eruption of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01352",
    "question": "What phenotype is associated with Reese retinal dysplasia?",
    "seeds": [
      "Reese retinal dysplasia"
    ],
    "gold_answer": "Remnants of the hyaloid vascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01353",
    "question": "What is associated with Sternocleidomastoid amyotrophy?",
    "seeds": [
      "Sternocleidomastoid amyotrophy"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01354",
    "question": "What is associated with Joubert syndrome 38?",
    "seeds": [
      "Joubert syndrome 38"
    ],
    "gold_answer": "Abnormal frontal bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01355",
    "question": "What is associated with Decreased circulating antimullerian hormone circulation?",
    "seeds": [
      "Decreased circulating antimullerian hormone circulation"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01356",
    "question": "What is associated with Double inlet left ventricle?",
    "seeds": [
      "Double inlet left ventricle"
    ],
    "gold_answer": "Abnormal connection of the cardiac segments",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01357",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 46?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 46"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01358",
    "question": "What is associated with Fragmentation of the epiphysis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Fragmentation of the epiphysis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the distal phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01359",
    "question": "What is associated with Pharyngalgia?",
    "seeds": [
      "Pharyngalgia"
    ],
    "gold_answer": "Abnormality of the upper respiratory tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01360",
    "question": "What is associated with Cardiomyopathy, dilated, 1H?",
    "seeds": [
      "Cardiomyopathy, dilated, 1H"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01361",
    "question": "What is associated with Osteolysis of patellae?",
    "seeds": [
      "Osteolysis of patellae"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01362",
    "question": "What is associated with Cementum overgrowth?",
    "seeds": [
      "Cementum overgrowth"
    ],
    "gold_answer": "Abnormal odontoid tissue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01363",
    "question": "What is associated with Disinhibition?",
    "seeds": [
      "Disinhibition"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01364",
    "question": "What is associated with Vitreomacular adhesion?",
    "seeds": [
      "Vitreomacular adhesion"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01365",
    "question": "What is associated with Filippi syndrome?",
    "seeds": [
      "Filippi syndrome"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01366",
    "question": "What is associated with Ehlers-Danlos syndrome, spondylodysplastic type, 1?",
    "seeds": [
      "Ehlers-Danlos syndrome, spondylodysplastic type, 1"
    ],
    "gold_answer": "Submucous cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01367",
    "question": "What is associated with Abnormal alpha granule distribution?",
    "seeds": [
      "Abnormal alpha granule distribution"
    ],
    "gold_answer": "Abnormal platelet granules",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01368",
    "question": "What is associated with Compensated hemolytic anemia?",
    "seeds": [
      "Compensated hemolytic anemia"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01369",
    "question": "What is associated with Myasthenic syndrome, congenital, 2A, slow-channel?",
    "seeds": [
      "Myasthenic syndrome, congenital, 2A, slow-channel"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01370",
    "question": "What is associated with Adams-Oliver syndrome 1?",
    "seeds": [
      "Adams-Oliver syndrome 1"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01371",
    "question": "What is associated with Verrucous cell carcinoma of the tongue?",
    "seeds": [
      "Verrucous cell carcinoma of the tongue"
    ],
    "gold_answer": "Squamous cell carcinoma of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01372",
    "question": "What is associated with STXBP1-related encephalopathy?",
    "seeds": [
      "STXBP1-related encephalopathy"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01373",
    "question": "What is associated with Shwachman-Diamond syndrome 2?",
    "seeds": [
      "Shwachman-Diamond syndrome 2"
    ],
    "gold_answer": "Abnormality of the knee",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01374",
    "question": "What is associated with Pharyngitis?",
    "seeds": [
      "Pharyngitis"
    ],
    "gold_answer": "Abnormality of the pharynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01375",
    "question": "What is associated with Familial median cleft of the upper and lower lips?",
    "seeds": [
      "Familial median cleft of the upper and lower lips"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01376",
    "question": "What is associated with Impaired annexin V binding to platelet phosphatidylserine?",
    "seeds": [
      "Impaired annexin V binding to platelet phosphatidylserine"
    ],
    "gold_answer": "Abnormal platelet function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01377",
    "question": "What is associated with Abnormal reticulocyte morphology?",
    "seeds": [
      "Abnormal reticulocyte morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01378",
    "question": "What is associated with Darier-White disease?",
    "seeds": [
      "Darier-White disease"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01379",
    "question": "What is associated with Proximal spinal muscular atrophy?",
    "seeds": [
      "Proximal spinal muscular atrophy"
    ],
    "gold_answer": "Pneumonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01380",
    "question": "What is associated with Rapidly involuting congenital hemangioma?",
    "seeds": [
      "Rapidly involuting congenital hemangioma"
    ],
    "gold_answer": "Arteriovenous malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01381",
    "question": "What is associated with Peripheral thrombosis?",
    "seeds": [
      "Peripheral thrombosis"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01382",
    "question": "What is associated with Homozygous hemoglobin O Arab disease?",
    "seeds": [
      "Homozygous hemoglobin O Arab disease"
    ],
    "gold_answer": "HBB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01383",
    "question": "What is associated with Short thumb?",
    "seeds": [
      "Short thumb"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01384",
    "question": "What is associated with Macular degeneration, age-related, 2?",
    "seeds": [
      "Macular degeneration, age-related, 2"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01385",
    "question": "What is associated with Epidermolysis bullosa simplex 2C, localized?",
    "seeds": [
      "Epidermolysis bullosa simplex 2C, localized"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01386",
    "question": "What is associated with Mitochondrial DNA depletion syndrome 14A (encephalomyopathic type)?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 14A (encephalomyopathic type)"
    ],
    "gold_answer": "Appendicular spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01387",
    "question": "What is associated with Developmental delay, impaired speech, and behavioral abnormalities, with or without seizures?",
    "seeds": [
      "Developmental delay, impaired speech, and behavioral abnormalities, with or without seizures"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01388",
    "question": "What is associated with Fibular deviation of the 2nd toe?",
    "seeds": [
      "Fibular deviation of the 2nd toe"
    ],
    "gold_answer": "Deviation of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01389",
    "question": "What is associated with Enchondroma?",
    "seeds": [
      "Enchondroma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01390",
    "question": "What phenotype is associated with Hemochromatosis, type 2A?",
    "seeds": [
      "Hemochromatosis, type 2A"
    ],
    "gold_answer": "Hyperpigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01391",
    "question": "What is associated with Absent epiphyses of the 4th finger?",
    "seeds": [
      "Absent epiphyses of the 4th finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01392",
    "question": "What is associated with Abnormal LDL cholesterol concentration?",
    "seeds": [
      "Abnormal LDL cholesterol concentration"
    ],
    "gold_answer": "Abnormal circulating cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01393",
    "question": "What is associated with Upper motor neuron dysfunction?",
    "seeds": [
      "Upper motor neuron dysfunction"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01394",
    "question": "What is associated with Neurodevelopmental disorder with poor growth, absent speech, progressive ataxia, and dysmorphic facies?",
    "seeds": [
      "Neurodevelopmental disorder with poor growth, absent speech, progressive ataxia, and dysmorphic facies"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01395",
    "question": "What is associated with Seizures-intellectual disability due to hydroxylysinuria syndrome?",
    "seeds": [
      "Seizures-intellectual disability due to hydroxylysinuria syndrome"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01396",
    "question": "What is associated with Cleft palate-lateral synechia syndrome?",
    "seeds": [
      "Cleft palate-lateral synechia syndrome"
    ],
    "gold_answer": "Craniofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01397",
    "question": "What is associated with Hypoplasia of the vestibule of the inner ear?",
    "seeds": [
      "Hypoplasia of the vestibule of the inner ear"
    ],
    "gold_answer": "Abnormal morphology of the vestibule of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01398",
    "question": "What is associated with Myopia 23, autosomal recessive?",
    "seeds": [
      "Myopia 23, autosomal recessive"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01399",
    "question": "What is associated with Cone-shaped epiphysis?",
    "seeds": [
      "Cone-shaped epiphysis"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01400",
    "question": "What is associated with Brachydactyly, type A6?",
    "seeds": [
      "Brachydactyly, type A6"
    ],
    "gold_answer": "Abnormal carpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01401",
    "question": "What is associated with Ultra-low vision with no light perception?",
    "seeds": [
      "Ultra-low vision with no light perception"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01402",
    "question": "What is associated with Familial drusen?",
    "seeds": [
      "Familial drusen"
    ],
    "gold_answer": "Abnormal posterior segment imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01403",
    "question": "What is associated with Increased globoside Gb3 level?",
    "seeds": [
      "Increased globoside Gb3 level"
    ],
    "gold_answer": "Abnormal tissue metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01404",
    "question": "What is associated with Preterm premature rupture of the membranes?",
    "seeds": [
      "Preterm premature rupture of the membranes"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01405",
    "question": "What is associated with Elevated circulating surfactant protein concentration?",
    "seeds": [
      "Elevated circulating surfactant protein concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01406",
    "question": "What is associated with Tubulointerstitial fungal infiltration?",
    "seeds": [
      "Tubulointerstitial fungal infiltration"
    ],
    "gold_answer": "Tubulointerstitial microganismal infiltration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01407",
    "question": "What is associated with Ectodermal dysplasia 12, Hypohidrotic/hair/tooth/nail type?",
    "seeds": [
      "Ectodermal dysplasia 12, Hypohidrotic/hair/tooth/nail type"
    ],
    "gold_answer": "Abnormal upper lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01408",
    "question": "What phenotype is associated with Arts syndrome?",
    "seeds": [
      "Arts syndrome"
    ],
    "gold_answer": "Drooling",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01409",
    "question": "What is associated with Rectal prolapse?",
    "seeds": [
      "Rectal prolapse"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01410",
    "question": "What is associated with Blepharophimosis, epicanthus inversus, and ptosis?",
    "seeds": [
      "Blepharophimosis, epicanthus inversus, and ptosis"
    ],
    "gold_answer": "Abnormal nasal bridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01411",
    "question": "What is associated with Hypertension and brachydactyly syndrome?",
    "seeds": [
      "Hypertension and brachydactyly syndrome"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01412",
    "question": "What is associated with Short stature-delayed bone age due to thyroid hormone metabolism deficiency?",
    "seeds": [
      "Short stature-delayed bone age due to thyroid hormone metabolism deficiency"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01413",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 54?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 54"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01414",
    "question": "What is associated with Retinal vasculitis?",
    "seeds": [
      "Retinal vasculitis"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01415",
    "question": "What is associated with Episodic abdominal pain?",
    "seeds": [
      "Episodic abdominal pain"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01416",
    "question": "What phenotype is associated with Autoinflammation with infantile enterocolitis?",
    "seeds": [
      "Autoinflammation with infantile enterocolitis"
    ],
    "gold_answer": "Decreased circulating complement C4 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01417",
    "question": "What is associated with Hereditary leiomyomatosis and renal cell cancer?",
    "seeds": [
      "Hereditary leiomyomatosis and renal cell cancer"
    ],
    "gold_answer": "Leiomyosarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01418",
    "question": "What phenotype is associated with Chromosome 19q13.11 deletion syndrome, distal?",
    "seeds": [
      "Chromosome 19q13.11 deletion syndrome, distal"
    ],
    "gold_answer": "Cyclopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01419",
    "question": "What is associated with 8q22.1 microdeletion syndrome?",
    "seeds": [
      "8q22.1 microdeletion syndrome"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01420",
    "question": "What is associated with Epilepsy, rolandic, with paroxysmal exercise-induced dystonia and writer's cramp?",
    "seeds": [
      "Epilepsy, rolandic, with paroxysmal exercise-induced dystonia and writer's cramp"
    ],
    "gold_answer": "Tremor by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01421",
    "question": "What is associated with Spastic ataxia with congenital miosis?",
    "seeds": [
      "Spastic ataxia with congenital miosis"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01422",
    "question": "What is associated with Cervical hypoplasia?",
    "seeds": [
      "Cervical hypoplasia"
    ],
    "gold_answer": "Abnormality of the uterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01423",
    "question": "What phenotype is associated with Insulin autoimmune syndrome?",
    "seeds": [
      "Insulin autoimmune syndrome"
    ],
    "gold_answer": "Arthralgia/arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01424",
    "question": "What is associated with Abnormal cerebellar cortex morphology?",
    "seeds": [
      "Abnormal cerebellar cortex morphology"
    ],
    "gold_answer": "Abnormal hindbrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01425",
    "question": "What phenotype is associated with Midface hypoplasia, obesity, developmental delay, and neonatal hypotonia?",
    "seeds": [
      "Midface hypoplasia, obesity, developmental delay, and neonatal hypotonia"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01426",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 47, and lissencephaly?",
    "seeds": [
      "Ciliary dyskinesia, primary, 47, and lissencephaly"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01427",
    "question": "What phenotype is associated with X-linked Alport syndrome-diffuse leiomyomatosis?",
    "seeds": [
      "X-linked Alport syndrome-diffuse leiomyomatosis"
    ],
    "gold_answer": "Dyspepsia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01428",
    "question": "What is associated with Subepithelial glomerular basement membrane electron dense deposits?",
    "seeds": [
      "Subepithelial glomerular basement membrane electron dense deposits"
    ],
    "gold_answer": "Abnormal glomerular basement membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01429",
    "question": "What is associated with Dilated superficial abdominal veins?",
    "seeds": [
      "Dilated superficial abdominal veins"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01430",
    "question": "What is associated with Ameliorated by immunosuppresion?",
    "seeds": [
      "Ameliorated by immunosuppresion"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01431",
    "question": "What is associated with Gabriele-de Vries syndrome?",
    "seeds": [
      "Gabriele-de Vries syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01432",
    "question": "What is associated with Depressed nasal ridge?",
    "seeds": [
      "Depressed nasal ridge"
    ],
    "gold_answer": "Abnormal nasal dorsum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01433",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 15?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 15"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01434",
    "question": "What is associated with Abnormal coronary artery course?",
    "seeds": [
      "Abnormal coronary artery course"
    ],
    "gold_answer": "Abnormal coronary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01435",
    "question": "What is associated with Ovarian serous cystadenoma?",
    "seeds": [
      "Ovarian serous cystadenoma"
    ],
    "gold_answer": "Ovarian cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01436",
    "question": "What is associated with Lymphatic malformation 2?",
    "seeds": [
      "Lymphatic malformation 2"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01437",
    "question": "What phenotype is associated with Craniosynostosis, Adelaide type?",
    "seeds": [
      "Craniosynostosis, Adelaide type"
    ],
    "gold_answer": "Cone-shaped epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01438",
    "question": "What is associated with Severe infection?",
    "seeds": [
      "Severe infection"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01439",
    "question": "What is associated with Renal tubular karyomegaly?",
    "seeds": [
      "Renal tubular karyomegaly"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01440",
    "question": "What phenotype is associated with Immunodeficiency 18?",
    "seeds": [
      "Immunodeficiency 18"
    ],
    "gold_answer": "Recurrent gastroenteritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01441",
    "question": "What is associated with Episodic hemiplegia?",
    "seeds": [
      "Episodic hemiplegia"
    ],
    "gold_answer": "Weakness due to upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01442",
    "question": "What is associated with Epidermal nevus syndrome?",
    "seeds": [
      "Epidermal nevus syndrome"
    ],
    "gold_answer": "Abnormal superficial reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01443",
    "question": "What is associated with Cortical diaphyseal thickening of the upper limbs?",
    "seeds": [
      "Cortical diaphyseal thickening of the upper limbs"
    ],
    "gold_answer": "Abnormal diaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01444",
    "question": "What is associated with Foot pain?",
    "seeds": [
      "Foot pain"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01445",
    "question": "What is associated with Primary unilateral adrenal hyperplasia?",
    "seeds": [
      "Primary unilateral adrenal hyperplasia"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01446",
    "question": "What phenotype is associated with Distal renal tubular acidosis 3, with or without sensorineural hearing loss?",
    "seeds": [
      "Distal renal tubular acidosis 3, with or without sensorineural hearing loss"
    ],
    "gold_answer": "Bilateral sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01447",
    "question": "What is associated with Sclerosis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Sclerosis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Sclerosis of proximal phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01448",
    "question": "What is associated with Leber congenital amaurosis 12?",
    "seeds": [
      "Leber congenital amaurosis 12"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01449",
    "question": "What is associated with Lymphatic malformation 14?",
    "seeds": [
      "Lymphatic malformation 14"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01450",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 15?",
    "seeds": [
      "Developmental and epileptic encephalopathy 15"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01451",
    "question": "What is associated with Pseudoepiphyses of the 4th toe?",
    "seeds": [
      "Pseudoepiphyses of the 4th toe"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01452",
    "question": "What is associated with Elevated urinary N,N-dimethylglycine level?",
    "seeds": [
      "Elevated urinary N,N-dimethylglycine level"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01453",
    "question": "What is associated with Autosomal dominant striatal neurodegeneration?",
    "seeds": [
      "Autosomal dominant striatal neurodegeneration"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01454",
    "question": "What phenotype is associated with Cervical rib?",
    "seeds": [
      "Cervical rib"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01455",
    "question": "What is associated with Satyr ear?",
    "seeds": [
      "Satyr ear"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01456",
    "question": "What is associated with Small epiphysis of the 1st metatarsal?",
    "seeds": [
      "Small epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Abnormality of the epiphysis of the 1st metatarsal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01457",
    "question": "What is associated with Pyknoachondrogenesis?",
    "seeds": [
      "Pyknoachondrogenesis"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01458",
    "question": "What phenotype is associated with Athrombia, essential?",
    "seeds": [
      "Athrombia, essential"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01459",
    "question": "What is associated with Progressive bifocal chorioretinal atrophy?",
    "seeds": [
      "Progressive bifocal chorioretinal atrophy"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01460",
    "question": "What is associated with Hip dysplasia?",
    "seeds": [
      "Hip dysplasia"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01461",
    "question": "What is associated with Alopecia-contractures-dwarfism-intellectual disability syndrome?",
    "seeds": [
      "Alopecia-contractures-dwarfism-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01462",
    "question": "What is associated with Projectile vomiting?",
    "seeds": [
      "Projectile vomiting"
    ],
    "gold_answer": "Vomiting",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01463",
    "question": "What is associated with Decreased circulating biotinidase concentration?",
    "seeds": [
      "Decreased circulating biotinidase concentration"
    ],
    "gold_answer": "Abnormal circulating biotinidase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01464",
    "question": "What is associated with Intrahepatic bile duct dilatation?",
    "seeds": [
      "Intrahepatic bile duct dilatation"
    ],
    "gold_answer": "Abnormal biliary tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01465",
    "question": "What is associated with Inherited congenital spastic tetraplegia?",
    "seeds": [
      "Inherited congenital spastic tetraplegia"
    ],
    "gold_answer": "ADD3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_test_01466",
    "question": "What is associated with Arginine vasopressin deficiency?",
    "seeds": [
      "Arginine vasopressin deficiency"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01467",
    "question": "What is associated with 15q13.3 microdeletion syndrome?",
    "seeds": [
      "15q13.3 microdeletion syndrome"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01468",
    "question": "What is associated with Abnormal memory T cell proportion?",
    "seeds": [
      "Abnormal memory T cell proportion"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01469",
    "question": "What is associated with Facial paresis, hereditary congenital, 1?",
    "seeds": [
      "Facial paresis, hereditary congenital, 1"
    ],
    "gold_answer": "Weakness of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01470",
    "question": "What is associated with Constrictive pericarditis?",
    "seeds": [
      "Constrictive pericarditis"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01471",
    "question": "What is associated with Decreased CSF leucine concentration?",
    "seeds": [
      "Decreased CSF leucine concentration"
    ],
    "gold_answer": "Abnormal CSF leucine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01472",
    "question": "What is associated with Abnormal cervical spine morphology?",
    "seeds": [
      "Abnormal cervical spine morphology"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01473",
    "question": "What phenotype is associated with Mitochondrial complex IV deficiency, nuclear type 10?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 10"
    ],
    "gold_answer": "Renal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01474",
    "question": "What phenotype is associated with Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements"
    ],
    "gold_answer": "Inability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01475",
    "question": "What is associated with Parachute mitral valve?",
    "seeds": [
      "Parachute mitral valve"
    ],
    "gold_answer": "Abnormal mitral valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01476",
    "question": "What phenotype is associated with Febrile seizures, familial, 8?",
    "seeds": [
      "Febrile seizures, familial, 8"
    ],
    "gold_answer": "Bilateral tonic-clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01477",
    "question": "What is associated with Undetectable light-adapted electroretinogram?",
    "seeds": [
      "Undetectable light-adapted electroretinogram"
    ],
    "gold_answer": "Abnormal electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01478",
    "question": "What phenotype is associated with Dentici-Novelli neurodevelopmental syndrome?",
    "seeds": [
      "Dentici-Novelli neurodevelopmental syndrome"
    ],
    "gold_answer": "Thin corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01479",
    "question": "What phenotype is associated with Pigmented nodular adrenocortical disease, primary, 1?",
    "seeds": [
      "Pigmented nodular adrenocortical disease, primary, 1"
    ],
    "gold_answer": "Psychosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01480",
    "question": "What is associated with Jerky head movements?",
    "seeds": [
      "Jerky head movements"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01481",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2Y?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2Y"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01482",
    "question": "What phenotype is associated with Neuroendocrine tumor of stomach?",
    "seeds": [
      "Neuroendocrine tumor of stomach"
    ],
    "gold_answer": "Increased urinary cortisol level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01483",
    "question": "What is associated with Anti-SARS-CoV-2 coronavirus antibody positivity?",
    "seeds": [
      "Anti-SARS-CoV-2 coronavirus antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01484",
    "question": "What is associated with Abnormal QRS voltage?",
    "seeds": [
      "Abnormal QRS voltage"
    ],
    "gold_answer": "Abnormal QRS complex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01485",
    "question": "What is associated with Cerebral cortex with spongiform changes?",
    "seeds": [
      "Cerebral cortex with spongiform changes"
    ],
    "gold_answer": "Abnormal cerebral cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01486",
    "question": "What is associated with Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to 10p11.21p12.31 microdeletion?",
    "seeds": [
      "Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to 10p11.21p12.31 microdeletion"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01487",
    "question": "What is associated with Conjunctival hamartoma?",
    "seeds": [
      "Conjunctival hamartoma"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01488",
    "question": "What is associated with Elevated circulating thymine concentration?",
    "seeds": [
      "Elevated circulating thymine concentration"
    ],
    "gold_answer": "Abnormal circulating nucleobase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01489",
    "question": "What is associated with Short nasal bridge?",
    "seeds": [
      "Short nasal bridge"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01490",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 9B?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 9B"
    ],
    "gold_answer": "Cognitive impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01491",
    "question": "What is associated with Macular degeneration?",
    "seeds": [
      "Macular degeneration"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01492",
    "question": "What is associated with Ventricular septal hypertrophy?",
    "seeds": [
      "Ventricular septal hypertrophy"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01493",
    "question": "What is associated with Abnormal renal physiology?",
    "seeds": [
      "Abnormal renal physiology"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01494",
    "question": "What is associated with Compound motor action potential abnormality?",
    "seeds": [
      "Compound motor action potential abnormality"
    ],
    "gold_answer": "Abnormal nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01495",
    "question": "What is associated with Costochondral joint sclerosis?",
    "seeds": [
      "Costochondral joint sclerosis"
    ],
    "gold_answer": "Abnormal rib morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01496",
    "question": "What is associated with T cell chronic lymphocytic lymphoma/leukemia?",
    "seeds": [
      "T cell chronic lymphocytic lymphoma/leukemia"
    ],
    "gold_answer": "Leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01497",
    "question": "What is associated with Ectopic parathyroid?",
    "seeds": [
      "Ectopic parathyroid"
    ],
    "gold_answer": "Parathyroid dysgenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01498",
    "question": "What is associated with Supernumerary tracheal bronchus?",
    "seeds": [
      "Supernumerary tracheal bronchus"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01499",
    "question": "What is associated with Congenital hydrocephalus?",
    "seeds": [
      "Congenital hydrocephalus"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01500",
    "question": "What is associated with Dermatosparaxis Ehlers-Danlos syndrome?",
    "seeds": [
      "Dermatosparaxis Ehlers-Danlos syndrome"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01501",
    "question": "What is associated with Surfactant metabolism dysfunction, pulmonary, 4?",
    "seeds": [
      "Surfactant metabolism dysfunction, pulmonary, 4"
    ],
    "gold_answer": "Abnormal DLCO",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01502",
    "question": "What is associated with Immunodeficiency 15?",
    "seeds": [
      "Immunodeficiency 15"
    ],
    "gold_answer": "Abnormal monocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01503",
    "question": "What phenotype is associated with Secondary syringomyelia?",
    "seeds": [
      "Secondary syringomyelia"
    ],
    "gold_answer": "Abnormality of central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01504",
    "question": "What is associated with Exercise intolerance, riboflavin-responsive?",
    "seeds": [
      "Exercise intolerance, riboflavin-responsive"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01505",
    "question": "What is associated with Mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency?",
    "seeds": [
      "Mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency"
    ],
    "gold_answer": "STAT1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01506",
    "question": "What is associated with Central centrifugal cicatricial alopecia?",
    "seeds": [
      "Central centrifugal cicatricial alopecia"
    ],
    "gold_answer": "Alopecia of scalp",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01507",
    "question": "What is associated with Variegate porphyria?",
    "seeds": [
      "Variegate porphyria"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01508",
    "question": "What is associated with Osteosclerosis of the base of the skull?",
    "seeds": [
      "Osteosclerosis of the base of the skull"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01509",
    "question": "What is associated with Retinitis pigmentosa 88?",
    "seeds": [
      "Retinitis pigmentosa 88"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01510",
    "question": "What is associated with Decreased body fat percentage?",
    "seeds": [
      "Decreased body fat percentage"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01511",
    "question": "What is associated with Premature ovarian failure 5?",
    "seeds": [
      "Premature ovarian failure 5"
    ],
    "gold_answer": "Abnormal antral follicle count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01512",
    "question": "What is associated with Delayed puberty?",
    "seeds": [
      "Delayed puberty"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01513",
    "question": "What phenotype is associated with Megalencephalic leukoencephalopathy with subcortical cysts 2B, remitting, with or without impaired intellectual development?",
    "seeds": [
      "Megalencephalic leukoencephalopathy with subcortical cysts 2B, remitting, with or without impaired intellectual development"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01514",
    "question": "What is associated with Third trimester onset?",
    "seeds": [
      "Third trimester onset"
    ],
    "gold_answer": "Antenatal onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01515",
    "question": "What is associated with Retinopathy, pericentral pigmentary, autosomal recessive?",
    "seeds": [
      "Retinopathy, pericentral pigmentary, autosomal recessive"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01516",
    "question": "What is associated with Abnormality of the epiphysis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Abnormality of the epiphysis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01517",
    "question": "What is associated with Abnormal alcohol consumption?",
    "seeds": [
      "Abnormal alcohol consumption"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01518",
    "question": "What is associated with Impacted teeth, multiple?",
    "seeds": [
      "Impacted teeth, multiple"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01519",
    "question": "What is associated with Phosphoenolpyruvate carboxykinase 2, mitochondrial?",
    "seeds": [
      "Phosphoenolpyruvate carboxykinase 2, mitochondrial"
    ],
    "gold_answer": "Abnormal hepatobiliary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01520",
    "question": "What is associated with Patchy sclerosis of proximal phalanx of finger?",
    "seeds": [
      "Patchy sclerosis of proximal phalanx of finger"
    ],
    "gold_answer": "Sclerosis of finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01521",
    "question": "What is associated with Breast microcalcification?",
    "seeds": [
      "Breast microcalcification"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01522",
    "question": "What is associated with Abnormal esophagus physiology?",
    "seeds": [
      "Abnormal esophagus physiology"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01523",
    "question": "What is associated with Cogwheel rigidity?",
    "seeds": [
      "Cogwheel rigidity"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01524",
    "question": "What is associated with External tibial torsion?",
    "seeds": [
      "External tibial torsion"
    ],
    "gold_answer": "Tibial torsion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01525",
    "question": "What is associated with Fractured distal phalanx of pedal digit 3?",
    "seeds": [
      "Fractured distal phalanx of pedal digit 3"
    ],
    "gold_answer": "Fractured distal phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01526",
    "question": "What is associated with Decreased sialylated N-glycan level?",
    "seeds": [
      "Decreased sialylated N-glycan level"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01527",
    "question": "What phenotype is associated with Noduli cutanei, multiple, with urinary tract abnormalities?",
    "seeds": [
      "Noduli cutanei, multiple, with urinary tract abnormalities"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01528",
    "question": "What is associated with Abnormal platelet function?",
    "seeds": [
      "Abnormal platelet function"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01529",
    "question": "What is associated with Cortical radial artery intima/media coagulative necrosis?",
    "seeds": [
      "Cortical radial artery intima/media coagulative necrosis"
    ],
    "gold_answer": "Abnormal cortical radial artery intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01530",
    "question": "What is associated with Dense metaphyseal bands?",
    "seeds": [
      "Dense metaphyseal bands"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01531",
    "question": "What is associated with Ivory epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Ivory epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Ivory epiphyses of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01532",
    "question": "What phenotype is associated with Cantú syndrome?",
    "seeds": [
      "Cantú syndrome"
    ],
    "gold_answer": "Finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01533",
    "question": "What is associated with Bloodstream microfilaria?",
    "seeds": [
      "Bloodstream microfilaria"
    ],
    "gold_answer": "Blood parasite",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01534",
    "question": "What is associated with Bullet-shaped distal phalanx of the 3rd toe?",
    "seeds": [
      "Bullet-shaped distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Bullet-shaped toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01535",
    "question": "What is associated with Everted lower lip vermilion?",
    "seeds": [
      "Everted lower lip vermilion"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01536",
    "question": "What is associated with Scalp edema?",
    "seeds": [
      "Scalp edema"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01537",
    "question": "What is associated with Abnormal total T cell count?",
    "seeds": [
      "Abnormal total T cell count"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01538",
    "question": "What is associated with Epiphyseal stippling of toe phalanges?",
    "seeds": [
      "Epiphyseal stippling of toe phalanges"
    ],
    "gold_answer": "Abnormal epiphyseal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01539",
    "question": "What is associated with Hypertriglyceridemia?",
    "seeds": [
      "Hypertriglyceridemia"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01540",
    "question": "What is associated with Corticotropin-releasing hormone receptor defect?",
    "seeds": [
      "Corticotropin-releasing hormone receptor defect"
    ],
    "gold_answer": "Central adrenal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01541",
    "question": "What is associated with Microphthalmia with hyperopia, retinal degeneration, macrophakia,and dental anomalies?",
    "seeds": [
      "Microphthalmia with hyperopia, retinal degeneration, macrophakia,and dental anomalies"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01542",
    "question": "What is associated with Dental radicular dysplasia?",
    "seeds": [
      "Dental radicular dysplasia"
    ],
    "gold_answer": "Agenesis of molar",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01543",
    "question": "What is associated with Progressive calcification of costochondral cartilage?",
    "seeds": [
      "Progressive calcification of costochondral cartilage"
    ],
    "gold_answer": "Abnormality of the costochondral junction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01544",
    "question": "What is associated with Anterior chamber flare grade 1+?",
    "seeds": [
      "Anterior chamber flare grade 1+"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01545",
    "question": "What phenotype is associated with Grouped pigmentation of the macula?",
    "seeds": [
      "Grouped pigmentation of the macula"
    ],
    "gold_answer": "Metamorphopsia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01546",
    "question": "What is associated with GATA2 deficiency spectrum?",
    "seeds": [
      "GATA2 deficiency spectrum"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01547",
    "question": "What is associated with Wieacker-Wolff syndrome?",
    "seeds": [
      "Wieacker-Wolff syndrome"
    ],
    "gold_answer": "Thoracic hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01548",
    "question": "What is associated with Abnormality of the epiphysis of the 1st metatarsal?",
    "seeds": [
      "Abnormality of the epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01549",
    "question": "What is associated with Myelocytic leukemia-like syndrome, familial, chronic?",
    "seeds": [
      "Myelocytic leukemia-like syndrome, familial, chronic"
    ],
    "gold_answer": "Chronic leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01550",
    "question": "What is associated with Addictive video game use?",
    "seeds": [
      "Addictive video game use"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01551",
    "question": "What is associated with Substantially elevated circulating ethanol concentration?",
    "seeds": [
      "Substantially elevated circulating ethanol concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01552",
    "question": "What is associated with Olecranon fracture?",
    "seeds": [
      "Olecranon fracture"
    ],
    "gold_answer": "Elbow fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01553",
    "question": "What is associated with Cleft palate, psychomotor retardation, and distinctive facial features?",
    "seeds": [
      "Cleft palate, psychomotor retardation, and distinctive facial features"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01554",
    "question": "What is associated with Foam cells with lamellar inclusion bodies?",
    "seeds": [
      "Foam cells with lamellar inclusion bodies"
    ],
    "gold_answer": "Foam cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01555",
    "question": "What is associated with Ridged fingernail?",
    "seeds": [
      "Ridged fingernail"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01556",
    "question": "What is associated with Chronic granulomatous disease, X-linked?",
    "seeds": [
      "Chronic granulomatous disease, X-linked"
    ],
    "gold_answer": "Recurrent lower respiratory tract infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01557",
    "question": "What is associated with Developmental and epileptic encephalopathy 106?",
    "seeds": [
      "Developmental and epileptic encephalopathy 106"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01558",
    "question": "What is associated with Typical urticaria pigmentosa?",
    "seeds": [
      "Typical urticaria pigmentosa"
    ],
    "gold_answer": "KIT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01559",
    "question": "What is associated with Cervical ectropion?",
    "seeds": [
      "Cervical ectropion"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01560",
    "question": "What is associated with Hepatic infarction?",
    "seeds": [
      "Hepatic infarction"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01561",
    "question": "What is associated with Fetal chylothorax?",
    "seeds": [
      "Fetal chylothorax"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01562",
    "question": "What is associated with Increased cotinine level?",
    "seeds": [
      "Increased cotinine level"
    ],
    "gold_answer": "Presence of xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01563",
    "question": "What is associated with Dorsal column degeneration?",
    "seeds": [
      "Dorsal column degeneration"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01564",
    "question": "What is associated with Spontaneous hematomas?",
    "seeds": [
      "Spontaneous hematomas"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01565",
    "question": "What is associated with Abnormal CSF urate concentration?",
    "seeds": [
      "Abnormal CSF urate concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01566",
    "question": "What is associated with Posterior synechiae of the anterior chamber?",
    "seeds": [
      "Posterior synechiae of the anterior chamber"
    ],
    "gold_answer": "Abnormal anterior chamber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01567",
    "question": "What is associated with Retrograde memory impairment?",
    "seeds": [
      "Retrograde memory impairment"
    ],
    "gold_answer": "Long term memory impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01568",
    "question": "What is associated with Distal?",
    "seeds": [
      "Distal"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01569",
    "question": "What is associated with Spermatogenic failure 95?",
    "seeds": [
      "Spermatogenic failure 95"
    ],
    "gold_answer": "Abnormal male reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01570",
    "question": "What is associated with Tibial pseudarthrosis?",
    "seeds": [
      "Tibial pseudarthrosis"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01571",
    "question": "What is associated with Mandibulofacial dysostosis?",
    "seeds": [
      "Mandibulofacial dysostosis"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01572",
    "question": "What is associated with Capsular cataract?",
    "seeds": [
      "Capsular cataract"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01573",
    "question": "What is associated with Absent epiphysis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Absent epiphysis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01574",
    "question": "What is associated with Diminished integration of verbal and non-verbal communicative behavior?",
    "seeds": [
      "Diminished integration of verbal and non-verbal communicative behavior"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01575",
    "question": "What is associated with Abnormal cardiac MRI?",
    "seeds": [
      "Abnormal cardiac MRI"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01576",
    "question": "What is associated with Long palpebral fissure?",
    "seeds": [
      "Long palpebral fissure"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01577",
    "question": "What is associated with Retinitis pigmentosa-intellectual disability-deafness-hypogonadism syndrome?",
    "seeds": [
      "Retinitis pigmentosa-intellectual disability-deafness-hypogonadism syndrome"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01578",
    "question": "What phenotype is associated with Nanophthalmos 4?",
    "seeds": [
      "Nanophthalmos 4"
    ],
    "gold_answer": "Microphthalmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01579",
    "question": "What is associated with Reduced circulating aldolase concentration?",
    "seeds": [
      "Reduced circulating aldolase concentration"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01580",
    "question": "What is associated with Occupational disability?",
    "seeds": [
      "Occupational disability"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01581",
    "question": "What is associated with Abnormal pulse pressure?",
    "seeds": [
      "Abnormal pulse pressure"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01582",
    "question": "What is associated with Lingual thyroid?",
    "seeds": [
      "Lingual thyroid"
    ],
    "gold_answer": "Ectopic thyroid",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01583",
    "question": "What is associated with X-linked intellectual disability, Najm type?",
    "seeds": [
      "X-linked intellectual disability, Najm type"
    ],
    "gold_answer": "Cerebral atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01584",
    "question": "What is associated with Peroneal tendon subluxation?",
    "seeds": [
      "Peroneal tendon subluxation"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01585",
    "question": "What is associated with Fetal tachycardia?",
    "seeds": [
      "Fetal tachycardia"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01586",
    "question": "What is associated with Abnormal lymph-node tissue architecture?",
    "seeds": [
      "Abnormal lymph-node tissue architecture"
    ],
    "gold_answer": "Abnormal lymph-node biospecimen",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01587",
    "question": "What is associated with Joubert syndrome 30?",
    "seeds": [
      "Joubert syndrome 30"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01588",
    "question": "What is associated with Positive Quantiferon tuberculosis test?",
    "seeds": [
      "Positive Quantiferon tuberculosis test"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01589",
    "question": "What is associated with Membranous subvalvular aortic stenosis?",
    "seeds": [
      "Membranous subvalvular aortic stenosis"
    ],
    "gold_answer": "Abnormal left ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01590",
    "question": "What is associated with Precipitous labor?",
    "seeds": [
      "Precipitous labor"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01591",
    "question": "What is associated with Aortic annulus calcification?",
    "seeds": [
      "Aortic annulus calcification"
    ],
    "gold_answer": "Aortic valve calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01592",
    "question": "What is associated with Anti-desmocollin antibody positivity?",
    "seeds": [
      "Anti-desmocollin antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01593",
    "question": "What is associated with Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome?",
    "seeds": [
      "Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01594",
    "question": "What is associated with Congenital ichthyosis-microcephalus-tetraplegia syndrome?",
    "seeds": [
      "Congenital ichthyosis-microcephalus-tetraplegia syndrome"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01595",
    "question": "What phenotype is associated with Ramos-Arroyo syndrome?",
    "seeds": [
      "Ramos-Arroyo syndrome"
    ],
    "gold_answer": "Broad face",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01596",
    "question": "What is associated with Communicating hydrocephalus?",
    "seeds": [
      "Communicating hydrocephalus"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01597",
    "question": "What phenotype is associated with AHDC1-related intellectual disability-obstructive sleep apnea-mild dysmorphism syndrome?",
    "seeds": [
      "AHDC1-related intellectual disability-obstructive sleep apnea-mild dysmorphism syndrome"
    ],
    "gold_answer": "Mild myopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01598",
    "question": "What is associated with Pineal cyst?",
    "seeds": [
      "Pineal cyst"
    ],
    "gold_answer": "Intracranial cystic lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01599",
    "question": "What is associated with Ulnar deviation of the wrist?",
    "seeds": [
      "Ulnar deviation of the wrist"
    ],
    "gold_answer": "Abnormality of the wrist",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01600",
    "question": "What phenotype is associated with Acromicric dysplasia?",
    "seeds": [
      "Acromicric dysplasia"
    ],
    "gold_answer": "Decreased nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01601",
    "question": "What phenotype is associated with Orthostatic hypotension 2?",
    "seeds": [
      "Orthostatic hypotension 2"
    ],
    "gold_answer": "Hypoglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01602",
    "question": "What phenotype is associated with Optic atrophy 3, autosomal dominant?",
    "seeds": [
      "Optic atrophy 3, autosomal dominant"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01603",
    "question": "What is associated with Shashi-Pena syndrome?",
    "seeds": [
      "Shashi-Pena syndrome"
    ],
    "gold_answer": "Abnormal blood glucose concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01604",
    "question": "What is associated with Bronchoconstriction?",
    "seeds": [
      "Bronchoconstriction"
    ],
    "gold_answer": "Abnormal bronchus physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01605",
    "question": "What is associated with Malar prominence?",
    "seeds": [
      "Malar prominence"
    ],
    "gold_answer": "Abnormal midface morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01606",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 3?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 3"
    ],
    "gold_answer": "Limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01607",
    "question": "What is associated with Renal arteriole neutrophil endoarterial hypercellularity?",
    "seeds": [
      "Renal arteriole neutrophil endoarterial hypercellularity"
    ],
    "gold_answer": "Abnormal renal arteriole endothelium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01608",
    "question": "What is associated with Cardiomyopathy, dilated, 1K?",
    "seeds": [
      "Cardiomyopathy, dilated, 1K"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01609",
    "question": "What is associated with Abnormal circulating mannose-binding protein concentration?",
    "seeds": [
      "Abnormal circulating mannose-binding protein concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01610",
    "question": "What is associated with Secondary non-traumatic avascular necrosis?",
    "seeds": [
      "Secondary non-traumatic avascular necrosis"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01611",
    "question": "What is associated with Cardiac shunt?",
    "seeds": [
      "Cardiac shunt"
    ],
    "gold_answer": "Abnormality of blood circulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01612",
    "question": "What is associated with Myasthenic syndrome, congenital, 19?",
    "seeds": [
      "Myasthenic syndrome, congenital, 19"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01613",
    "question": "What is associated with Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity?",
    "seeds": [
      "Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01614",
    "question": "What is associated with Isolated humero-radial synostosis?",
    "seeds": [
      "Isolated humero-radial synostosis"
    ],
    "gold_answer": "Abnormal elbow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01615",
    "question": "What phenotype is associated with Blepharochalasis and double lip?",
    "seeds": [
      "Blepharochalasis and double lip"
    ],
    "gold_answer": "Goiter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01616",
    "question": "What is associated with Eclabion?",
    "seeds": [
      "Eclabion"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01617",
    "question": "What is associated with Progressive cone dystrophy?",
    "seeds": [
      "Progressive cone dystrophy"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01618",
    "question": "What is associated with Distal 2nd toe symphalangism?",
    "seeds": [
      "Distal 2nd toe symphalangism"
    ],
    "gold_answer": "Second toe symphalangism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01619",
    "question": "What is associated with Brachydactyly type A7?",
    "seeds": [
      "Brachydactyly type A7"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01620",
    "question": "What is associated with Anterior predominant thick cortex pachygyria?",
    "seeds": [
      "Anterior predominant thick cortex pachygyria"
    ],
    "gold_answer": "Thick pachygyria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01621",
    "question": "What is associated with Progressive loss of facial adipose tissue?",
    "seeds": [
      "Progressive loss of facial adipose tissue"
    ],
    "gold_answer": "Abnormality of facial adipose tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01622",
    "question": "What is associated with Sertoli cell-only syndrome?",
    "seeds": [
      "Sertoli cell-only syndrome"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01623",
    "question": "What is associated with Skewed maternal X inactivation?",
    "seeds": [
      "Skewed maternal X inactivation"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01624",
    "question": "What is associated with Broad proximal phalanx of the 3rd finger?",
    "seeds": [
      "Broad proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Broad phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01625",
    "question": "What is associated with Flexion contracture of finger?",
    "seeds": [
      "Flexion contracture of finger"
    ],
    "gold_answer": "Abnormality of upper limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01626",
    "question": "What is associated with CSF varicella zoster antibody positivity?",
    "seeds": [
      "CSF varicella zoster antibody positivity"
    ],
    "gold_answer": "CSF pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01627",
    "question": "What phenotype is associated with Trichodental dysplasia?",
    "seeds": [
      "Trichodental dysplasia"
    ],
    "gold_answer": "Hypocalcification of dental enamel",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01628",
    "question": "What is associated with Paranasal sinus hypoplasia?",
    "seeds": [
      "Paranasal sinus hypoplasia"
    ],
    "gold_answer": "Absent/hypoplastic paranasal sinuses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01629",
    "question": "What phenotype is associated with Brachydactyly, type A1, D?",
    "seeds": [
      "Brachydactyly, type A1, D"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01630",
    "question": "What is associated with Conjunctival hamartoma?",
    "seeds": [
      "Conjunctival hamartoma"
    ],
    "gold_answer": "Hamartoma of the orbital region",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01631",
    "question": "What is associated with Interlobular vein intima/media venulitis?",
    "seeds": [
      "Interlobular vein intima/media venulitis"
    ],
    "gold_answer": "Abnormal interlobular vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01632",
    "question": "What is associated with Offspring of consanguineous relationship?",
    "seeds": [
      "Offspring of consanguineous relationship"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01633",
    "question": "What is associated with Secondary hyperparathyroidism?",
    "seeds": [
      "Secondary hyperparathyroidism"
    ],
    "gold_answer": "Abnormality of the parathyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01634",
    "question": "What is associated with Abnormal lateral cricoarytenoid muscle morphology?",
    "seeds": [
      "Abnormal lateral cricoarytenoid muscle morphology"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01635",
    "question": "What is associated with Focal lupus nephritis?",
    "seeds": [
      "Focal lupus nephritis"
    ],
    "gold_answer": "Glomerulonephritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01636",
    "question": "What is associated with Lymphadenopathy?",
    "seeds": [
      "Lymphadenopathy"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01637",
    "question": "What phenotype is associated with Thyroid hormone plasma membrane transport defect?",
    "seeds": [
      "Thyroid hormone plasma membrane transport defect"
    ],
    "gold_answer": "Euthyroid hyperthyroxinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01638",
    "question": "What is associated with Reduced circulating aspartate aminotransferase concentration?",
    "seeds": [
      "Reduced circulating aspartate aminotransferase concentration"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01639",
    "question": "What is associated with Pancreatic hamartoma?",
    "seeds": [
      "Pancreatic hamartoma"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01640",
    "question": "What is associated with Increased total natural killer cell count?",
    "seeds": [
      "Increased total natural killer cell count"
    ],
    "gold_answer": "Abnormal total natural killer cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01641",
    "question": "What is associated with Interstitial cardiac fibrosis?",
    "seeds": [
      "Interstitial cardiac fibrosis"
    ],
    "gold_answer": "Myocardial fibrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01642",
    "question": "What is associated with Maturity-onset diabetes of the young, type II?",
    "seeds": [
      "Maturity-onset diabetes of the young, type II"
    ],
    "gold_answer": "Diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01643",
    "question": "What is associated with Frailty?",
    "seeds": [
      "Frailty"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01644",
    "question": "What is associated with Mitochondrial complex V (ATP synthase) deficiency nuclear type 5?",
    "seeds": [
      "Mitochondrial complex V (ATP synthase) deficiency nuclear type 5"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01645",
    "question": "What is associated with Recurrent long bone fractures?",
    "seeds": [
      "Recurrent long bone fractures"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01646",
    "question": "What phenotype is associated with Cd8 deficiency, familial?",
    "seeds": [
      "Cd8 deficiency, familial"
    ],
    "gold_answer": "Absence of CD8-positive T cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01647",
    "question": "What is associated with Delayed ability to sit?",
    "seeds": [
      "Delayed ability to sit"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01648",
    "question": "What is associated with Porokeratosis 9, multiple types?",
    "seeds": [
      "Porokeratosis 9, multiple types"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01649",
    "question": "What is associated with Neologism?",
    "seeds": [
      "Neologism"
    ],
    "gold_answer": "Abnormal semantics",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01650",
    "question": "What phenotype is associated with Microduplication Xp11.22p11.23 syndrome?",
    "seeds": [
      "Microduplication Xp11.22p11.23 syndrome"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01651",
    "question": "What phenotype is associated with Peroxisome biogenesis disorder 3B?",
    "seeds": [
      "Peroxisome biogenesis disorder 3B"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01652",
    "question": "What phenotype is associated with Denys-Drash syndrome?",
    "seeds": [
      "Denys-Drash syndrome"
    ],
    "gold_answer": "Diffuse mesangial sclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01653",
    "question": "What is associated with Neutrophil actin dysfunction?",
    "seeds": [
      "Neutrophil actin dysfunction"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01654",
    "question": "What is associated with Carotid cavernous fistula?",
    "seeds": [
      "Carotid cavernous fistula"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01655",
    "question": "What is associated with Broad middle phalanx of the 2nd toe?",
    "seeds": [
      "Broad middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal 2nd toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01656",
    "question": "What is associated with Corpus callosum, agenesis of, with impaired intellectual development, ocular coloboma and micrognathia?",
    "seeds": [
      "Corpus callosum, agenesis of, with impaired intellectual development, ocular coloboma and micrognathia"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01657",
    "question": "What is associated with Chondrocalcinosis?",
    "seeds": [
      "Chondrocalcinosis"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01658",
    "question": "What phenotype is associated with Robin sequence with cleft mandible and limb anomalies?",
    "seeds": [
      "Robin sequence with cleft mandible and limb anomalies"
    ],
    "gold_answer": "Short thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01659",
    "question": "What is associated with Abnormal CD69 upregulation upon TCR activation?",
    "seeds": [
      "Abnormal CD69 upregulation upon TCR activation"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01660",
    "question": "What phenotype is associated with Metachondromatosis?",
    "seeds": [
      "Metachondromatosis"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01661",
    "question": "What is associated with Holocarboxylase synthetase deficiency?",
    "seeds": [
      "Holocarboxylase synthetase deficiency"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01662",
    "question": "What is associated with 1-2 finger cutaneous syndactyly?",
    "seeds": [
      "1-2 finger cutaneous syndactyly"
    ],
    "gold_answer": "Cutaneous finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01663",
    "question": "What is associated with Abnormal adipose tissue morphology?",
    "seeds": [
      "Abnormal adipose tissue morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01664",
    "question": "What is associated with Wide epiphyseal plates of the upper limbs?",
    "seeds": [
      "Wide epiphyseal plates of the upper limbs"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01665",
    "question": "What is associated with Triangular shaped proximal phalanx of the hallux?",
    "seeds": [
      "Triangular shaped proximal phalanx of the hallux"
    ],
    "gold_answer": "Triangular shaped phalanges of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01666",
    "question": "What is associated with Progressive visual loss?",
    "seeds": [
      "Progressive visual loss"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01667",
    "question": "What is associated with Palmar hyperlinearity?",
    "seeds": [
      "Palmar hyperlinearity"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01668",
    "question": "What is associated with Reduced tissue 3-methylglutaconyl-CoA hydratase activity?",
    "seeds": [
      "Reduced tissue 3-methylglutaconyl-CoA hydratase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01669",
    "question": "What is associated with Onion bulb formation?",
    "seeds": [
      "Onion bulb formation"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01670",
    "question": "What is associated with Exposure to birds?",
    "seeds": [
      "Exposure to birds"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01671",
    "question": "What phenotype is associated with Proximal fifth finger symphalangism?",
    "seeds": [
      "Proximal fifth finger symphalangism"
    ],
    "gold_answer": "Elbow dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01672",
    "question": "What phenotype is associated with Gemignani syndrome?",
    "seeds": [
      "Gemignani syndrome"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01673",
    "question": "What is associated with Neonatal electro-clinical motor seizure?",
    "seeds": [
      "Neonatal electro-clinical motor seizure"
    ],
    "gold_answer": "Neonatal seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01674",
    "question": "What is associated with Hypothyroidism, congenital, nongoitrous, 4?",
    "seeds": [
      "Hypothyroidism, congenital, nongoitrous, 4"
    ],
    "gold_answer": "Abnormal anterior fontanelle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01675",
    "question": "What phenotype is associated with Lipodystrophy, familial partial, type 6?",
    "seeds": [
      "Lipodystrophy, familial partial, type 6"
    ],
    "gold_answer": "Muscular dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01676",
    "question": "What is associated with Abnormal renal corticomedullary differentiation?",
    "seeds": [
      "Abnormal renal corticomedullary differentiation"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01677",
    "question": "What is associated with Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to 10p11.21p12.31 microdeletion?",
    "seeds": [
      "Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to 10p11.21p12.31 microdeletion"
    ],
    "gold_answer": "Short attention span",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01678",
    "question": "What is associated with Thymoma?",
    "seeds": [
      "Thymoma"
    ],
    "gold_answer": "Neoplasm of the thymus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01679",
    "question": "What is associated with Abnormal subthalamic nucleus morphology?",
    "seeds": [
      "Abnormal subthalamic nucleus morphology"
    ],
    "gold_answer": "Abnormal diencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01680",
    "question": "What is associated with Increased susceptibility to spontaneous sister chromatid exchange?",
    "seeds": [
      "Increased susceptibility to spontaneous sister chromatid exchange"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01681",
    "question": "What phenotype is associated with Progressive supranuclear palsy-corticobasal syndrome?",
    "seeds": [
      "Progressive supranuclear palsy-corticobasal syndrome"
    ],
    "gold_answer": "Abnormal pyramidal sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01682",
    "question": "What is associated with Axillary pterygium?",
    "seeds": [
      "Axillary pterygium"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01683",
    "question": "What is associated with Dark choroid?",
    "seeds": [
      "Dark choroid"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01684",
    "question": "What is associated with Aplasia/hypoplasia of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Aplasia/hypoplasia of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the phalanges of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01685",
    "question": "What is associated with Bracket epiphyses of the 2nd toe?",
    "seeds": [
      "Bracket epiphyses of the 2nd toe"
    ],
    "gold_answer": "Bracket epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01686",
    "question": "What is associated with Underdeveloped nasal alae?",
    "seeds": [
      "Underdeveloped nasal alae"
    ],
    "gold_answer": "Abnormal morphology of the nasal alae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01687",
    "question": "What is associated with Generalized hypertrichosis?",
    "seeds": [
      "Generalized hypertrichosis"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01688",
    "question": "What is associated with Bowel irritability?",
    "seeds": [
      "Bowel irritability"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01689",
    "question": "What is associated with Unilateral renal atrophy?",
    "seeds": [
      "Unilateral renal atrophy"
    ],
    "gold_answer": "Renal atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01690",
    "question": "What is associated with Bullet-shaped distal phalanx of the 2nd finger?",
    "seeds": [
      "Bullet-shaped distal phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormality of the phalanges of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01691",
    "question": "What is associated with Aplasia of lacrimal and salivary glands?",
    "seeds": [
      "Aplasia of lacrimal and salivary glands"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01692",
    "question": "What is associated with Aplasia cutis congenita of midline scalp vertex?",
    "seeds": [
      "Aplasia cutis congenita of midline scalp vertex"
    ],
    "gold_answer": "Aplasia cutis congenita over the scalp vertex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01693",
    "question": "What is associated with Abnormal chorion morphology?",
    "seeds": [
      "Abnormal chorion morphology"
    ],
    "gold_answer": "Abnormal placenta morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01694",
    "question": "What is associated with Focal emotional seizure?",
    "seeds": [
      "Focal emotional seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01695",
    "question": "What is associated with Seizure?",
    "seeds": [
      "Seizure"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01696",
    "question": "What is associated with Periventricular leukomalacia?",
    "seeds": [
      "Periventricular leukomalacia"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01697",
    "question": "What is associated with Prolonged bleeding following circumcision?",
    "seeds": [
      "Prolonged bleeding following circumcision"
    ],
    "gold_answer": "Prolonged bleeding following procedure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01698",
    "question": "What phenotype is associated with Nipah virus disease?",
    "seeds": [
      "Nipah virus disease"
    ],
    "gold_answer": "Headache",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01699",
    "question": "What is associated with Vestibular areflexia?",
    "seeds": [
      "Vestibular areflexia"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01700",
    "question": "What is associated with Renal medullary interstitial inflammation?",
    "seeds": [
      "Renal medullary interstitial inflammation"
    ],
    "gold_answer": "Abnormal renal interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01701",
    "question": "What phenotype is associated with Pentosuria?",
    "seeds": [
      "Pentosuria"
    ],
    "gold_answer": "Elevated urine L-xylulose level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01702",
    "question": "What is associated with Abnormality of the face?",
    "seeds": [
      "Abnormality of the face"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01703",
    "question": "What is associated with Right ventricular aneurysm?",
    "seeds": [
      "Right ventricular aneurysm"
    ],
    "gold_answer": "Abnormal right ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01704",
    "question": "What phenotype is associated with Mitochondrial DNA-associated Leigh syndrome?",
    "seeds": [
      "Mitochondrial DNA-associated Leigh syndrome"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01705",
    "question": "What is associated with Posterior rib fusion?",
    "seeds": [
      "Posterior rib fusion"
    ],
    "gold_answer": "Rib fusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01706",
    "question": "What is associated with Asymmetric peripheral demyelination?",
    "seeds": [
      "Asymmetric peripheral demyelination"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01707",
    "question": "What is associated with Lactose intolerance?",
    "seeds": [
      "Lactose intolerance"
    ],
    "gold_answer": "Malabsorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01708",
    "question": "What is associated with Abnormal esterified to free carnitine ratio?",
    "seeds": [
      "Abnormal esterified to free carnitine ratio"
    ],
    "gold_answer": "Abnormal circulating fatty-acid anion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01709",
    "question": "What is associated with Non-specific autoimmune supratentorial encephalitis with characteristic antibodies?",
    "seeds": [
      "Non-specific autoimmune supratentorial encephalitis with characteristic antibodies"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01710",
    "question": "What is associated with Hypoammonemia?",
    "seeds": [
      "Hypoammonemia"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01711",
    "question": "What is associated with Autosomal dominant Charcot-Marie-Tooth disease type 2Y?",
    "seeds": [
      "Autosomal dominant Charcot-Marie-Tooth disease type 2Y"
    ],
    "gold_answer": "Proximal lower limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01712",
    "question": "What is associated with Decreased erythrocyte UDP glucose-4-epimerase concentration?",
    "seeds": [
      "Decreased erythrocyte UDP glucose-4-epimerase concentration"
    ],
    "gold_answer": "Abnormal erythrocyte enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01713",
    "question": "What is associated with Alpha-EEG?",
    "seeds": [
      "Alpha-EEG"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01714",
    "question": "What is associated with Monosomy 9p syndrome?",
    "seeds": [
      "Monosomy 9p syndrome"
    ],
    "gold_answer": "Hyperactivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01715",
    "question": "What is associated with Urinary tract neoplasm?",
    "seeds": [
      "Urinary tract neoplasm"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01716",
    "question": "What is associated with Coloboma?",
    "seeds": [
      "Coloboma"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01717",
    "question": "What is associated with Idiopathic hypercalciuria?",
    "seeds": [
      "Idiopathic hypercalciuria"
    ],
    "gold_answer": "Abnormal blood inorganic cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01718",
    "question": "What is associated with CNS hypomyelination?",
    "seeds": [
      "CNS hypomyelination"
    ],
    "gold_answer": "Abnormal CNS myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01719",
    "question": "What is associated with Reduced fetal long bone echogenicity?",
    "seeds": [
      "Reduced fetal long bone echogenicity"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01720",
    "question": "What is associated with Proboscis lateralis?",
    "seeds": [
      "Proboscis lateralis"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01721",
    "question": "What is associated with Ivory epiphyses of the 4th toe?",
    "seeds": [
      "Ivory epiphyses of the 4th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01722",
    "question": "What is associated with Penile hypospadias?",
    "seeds": [
      "Penile hypospadias"
    ],
    "gold_answer": "Hypospadias",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01723",
    "question": "What is associated with Glyoxalase II deficiency?",
    "seeds": [
      "Glyoxalase II deficiency"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01724",
    "question": "What phenotype is associated with Congenital myopathy 18 due to dihydropyridine receptor defect?",
    "seeds": [
      "Congenital myopathy 18 due to dihydropyridine receptor defect"
    ],
    "gold_answer": "Increased variability in muscle fiber diameter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01725",
    "question": "What is associated with Paroxysmal nocturnal hemoglobinuria?",
    "seeds": [
      "Paroxysmal nocturnal hemoglobinuria"
    ],
    "gold_answer": "Abnormality of venous physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01726",
    "question": "What phenotype is associated with Leber optic atrophy, susceptibility to?",
    "seeds": [
      "Leber optic atrophy, susceptibility to"
    ],
    "gold_answer": "Leber optic atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01727",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 6?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 6"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01728",
    "question": "What is associated with Choroidal melanoma?",
    "seeds": [
      "Choroidal melanoma"
    ],
    "gold_answer": "Uveal melanoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01729",
    "question": "What is associated with Neoplasm of the central nervous system?",
    "seeds": [
      "Neoplasm of the central nervous system"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01730",
    "question": "What is associated with Sclerosis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Sclerosis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01731",
    "question": "What is associated with Sensory hyposensitivity unexplained by sensory deficit?",
    "seeds": [
      "Sensory hyposensitivity unexplained by sensory deficit"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01732",
    "question": "What is associated with Equinus calcaneus?",
    "seeds": [
      "Equinus calcaneus"
    ],
    "gold_answer": "Abnormality of the tarsal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01733",
    "question": "What is associated with Preauricular pit?",
    "seeds": [
      "Preauricular pit"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01734",
    "question": "What is associated with Cousin syndrome?",
    "seeds": [
      "Cousin syndrome"
    ],
    "gold_answer": "Joint stiffness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01735",
    "question": "What phenotype is associated with Distal deletion 15q syndrome?",
    "seeds": [
      "Distal deletion 15q syndrome"
    ],
    "gold_answer": "Pulmonary hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01736",
    "question": "What is associated with Absent otoacoustic emissions?",
    "seeds": [
      "Absent otoacoustic emissions"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01737",
    "question": "What is associated with Anti-HLA antibody positivity?",
    "seeds": [
      "Anti-HLA antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01738",
    "question": "What is associated with Bazex syndrome?",
    "seeds": [
      "Bazex syndrome"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01739",
    "question": "What phenotype is associated with Corpus callosum, partial agenesis of, X-linked?",
    "seeds": [
      "Corpus callosum, partial agenesis of, X-linked"
    ],
    "gold_answer": "Aganglionic megacolon",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01740",
    "question": "What is associated with Worster-Drought syndrome?",
    "seeds": [
      "Worster-Drought syndrome"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01741",
    "question": "What is associated with Increased circulating cathepsin D level?",
    "seeds": [
      "Increased circulating cathepsin D level"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01742",
    "question": "What is associated with Autoimmune neutropenia?",
    "seeds": [
      "Autoimmune neutropenia"
    ],
    "gold_answer": "Decreased total neutrophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01743",
    "question": "What phenotype is associated with Polydactyly-myopia syndrome?",
    "seeds": [
      "Polydactyly-myopia syndrome"
    ],
    "gold_answer": "Femoral hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01744",
    "question": "What is associated with Arteriosclerosis?",
    "seeds": [
      "Arteriosclerosis"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01745",
    "question": "What is associated with Epilepsy, familial adult myoclonic, 2?",
    "seeds": [
      "Epilepsy, familial adult myoclonic, 2"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01746",
    "question": "What is associated with Neoplasm?",
    "seeds": [
      "Neoplasm"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01747",
    "question": "What is associated with Spastic paraplegia 72B, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 72B, autosomal recessive"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01748",
    "question": "What is associated with Apnea, obstructive sleep?",
    "seeds": [
      "Apnea, obstructive sleep"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01749",
    "question": "What is associated with Reduced eye contact?",
    "seeds": [
      "Reduced eye contact"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01750",
    "question": "What is associated with Williams-Beuren region duplication syndrome?",
    "seeds": [
      "Williams-Beuren region duplication syndrome"
    ],
    "gold_answer": "Renal agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01751",
    "question": "What is associated with Urethrocele?",
    "seeds": [
      "Urethrocele"
    ],
    "gold_answer": "Vaginal hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01752",
    "question": "What phenotype is associated with Non-syndromic agammaglobulinemia?",
    "seeds": [
      "Non-syndromic agammaglobulinemia"
    ],
    "gold_answer": "Skin rash",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01753",
    "question": "What is associated with Keratinocyte vacuolization?",
    "seeds": [
      "Keratinocyte vacuolization"
    ],
    "gold_answer": "Abnormal epidermal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01754",
    "question": "What is associated with Congenital pyloric atresia?",
    "seeds": [
      "Congenital pyloric atresia"
    ],
    "gold_answer": "Abnormal stomach morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01755",
    "question": "What phenotype is associated with Epidermolysis bullosa simplex, Weber-Cockayne type?",
    "seeds": [
      "Epidermolysis bullosa simplex, Weber-Cockayne type"
    ],
    "gold_answer": "Hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01756",
    "question": "What is associated with Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome?",
    "seeds": [
      "Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome"
    ],
    "gold_answer": "Abnormality of facial soft tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01757",
    "question": "What is associated with Hypoplasia of the vagina?",
    "seeds": [
      "Hypoplasia of the vagina"
    ],
    "gold_answer": "Abnormal vagina morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01758",
    "question": "What is associated with Fanconi anemia, complementation group R?",
    "seeds": [
      "Fanconi anemia, complementation group R"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01759",
    "question": "What is associated with Frontolimbic dementia?",
    "seeds": [
      "Frontolimbic dementia"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01760",
    "question": "What is associated with Focal impaired awareness cognitive seizure?",
    "seeds": [
      "Focal impaired awareness cognitive seizure"
    ],
    "gold_answer": "Focal impaired awareness seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01761",
    "question": "What is associated with Hypoplasia of the abdominal wall musculature?",
    "seeds": [
      "Hypoplasia of the abdominal wall musculature"
    ],
    "gold_answer": "Abnormal morphology of the abdominal musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01762",
    "question": "What is associated with Anti-glycyl tRNA-synthetase antibody positivity?",
    "seeds": [
      "Anti-glycyl tRNA-synthetase antibody positivity"
    ],
    "gold_answer": "Anti-aminoacyl-tRNA synthetase antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01763",
    "question": "What is associated with Lumbar spondylosis?",
    "seeds": [
      "Lumbar spondylosis"
    ],
    "gold_answer": "Abnormal lumbar spine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01764",
    "question": "What is associated with Elevated urine dodecanedioic acid level?",
    "seeds": [
      "Elevated urine dodecanedioic acid level"
    ],
    "gold_answer": "Abnormal urine pH",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01765",
    "question": "What is associated with Increased lymph-node eosinophils?",
    "seeds": [
      "Increased lymph-node eosinophils"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01766",
    "question": "What is associated with Scleroderma, familial progressive?",
    "seeds": [
      "Scleroderma, familial progressive"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01767",
    "question": "What is associated with Noncommunicating hydrocephalus?",
    "seeds": [
      "Noncommunicating hydrocephalus"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01768",
    "question": "What phenotype is associated with Distal triplication 15q syndrome?",
    "seeds": [
      "Distal triplication 15q syndrome"
    ],
    "gold_answer": "Hydronephrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01769",
    "question": "What is associated with Stage 2 chronic kidney disease?",
    "seeds": [
      "Stage 2 chronic kidney disease"
    ],
    "gold_answer": "Renal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01770",
    "question": "What is associated with Hirsutism?",
    "seeds": [
      "Hirsutism"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01771",
    "question": "What is associated with Abnormal circulating acylcarnitine concentration?",
    "seeds": [
      "Abnormal circulating acylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating monocarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01772",
    "question": "What phenotype is associated with Lipoyltransferase 1 deficiency?",
    "seeds": [
      "Lipoyltransferase 1 deficiency"
    ],
    "gold_answer": "Hyperglutaminuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01773",
    "question": "What is associated with Absent zona pellucida?",
    "seeds": [
      "Absent zona pellucida"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01774",
    "question": "What is associated with Lacrimal duct aplasia?",
    "seeds": [
      "Lacrimal duct aplasia"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01775",
    "question": "What is associated with Macular atrophy?",
    "seeds": [
      "Macular atrophy"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01776",
    "question": "What is associated with Peripheral hypermyelination?",
    "seeds": [
      "Peripheral hypermyelination"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01777",
    "question": "What is associated with Reduced social smiling?",
    "seeds": [
      "Reduced social smiling"
    ],
    "gold_answer": "Reduced social responsiveness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01778",
    "question": "What is associated with Superficial episcleral hyperemia?",
    "seeds": [
      "Superficial episcleral hyperemia"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01779",
    "question": "What phenotype is associated with Paget disease of bone 6?",
    "seeds": [
      "Paget disease of bone 6"
    ],
    "gold_answer": "Elevated circulating alkaline phosphatase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01780",
    "question": "What is associated with Shoulder dimple?",
    "seeds": [
      "Shoulder dimple"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01781",
    "question": "What is associated with Increased CD4+ T cell proportion?",
    "seeds": [
      "Increased CD4+ T cell proportion"
    ],
    "gold_answer": "Abnormal CD4+ T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01782",
    "question": "What is associated with Transmantle columnar heterotopia?",
    "seeds": [
      "Transmantle columnar heterotopia"
    ],
    "gold_answer": "Gray matter heterotopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01783",
    "question": "What is associated with Methioninuria?",
    "seeds": [
      "Methioninuria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01784",
    "question": "What is associated with Clasp-knife sign?",
    "seeds": [
      "Clasp-knife sign"
    ],
    "gold_answer": "Appendicular spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01785",
    "question": "What phenotype is associated with Ocular cicatricial pemphigoid?",
    "seeds": [
      "Ocular cicatricial pemphigoid"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01786",
    "question": "What is associated with Tracheobronchmegaly?",
    "seeds": [
      "Tracheobronchmegaly"
    ],
    "gold_answer": "Abnormal tracheal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01787",
    "question": "What is associated with Diamond-Blackfan anemia 21?",
    "seeds": [
      "Diamond-Blackfan anemia 21"
    ],
    "gold_answer": "Abnormality of the calf",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01788",
    "question": "What is associated with Postinfectious vasculitis?",
    "seeds": [
      "Postinfectious vasculitis"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01789",
    "question": "What is associated with Reduced brain lactate level by MRS?",
    "seeds": [
      "Reduced brain lactate level by MRS"
    ],
    "gold_answer": "Abnormal brain lactate level by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01790",
    "question": "What is associated with Stiff hip?",
    "seeds": [
      "Stiff hip"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01791",
    "question": "What is associated with Aplasia/Hypoplasia of the phalanges of the thumb?",
    "seeds": [
      "Aplasia/Hypoplasia of the phalanges of the thumb"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01792",
    "question": "What is associated with Dystrophic epidermolysis bullosa pruriginosa?",
    "seeds": [
      "Dystrophic epidermolysis bullosa pruriginosa"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01793",
    "question": "What phenotype is associated with Odontodysplasia?",
    "seeds": [
      "Odontodysplasia"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01794",
    "question": "What is associated with CHIME syndrome?",
    "seeds": [
      "CHIME syndrome"
    ],
    "gold_answer": "Congenital malformation of the right heart",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01795",
    "question": "What is associated with Self hugging?",
    "seeds": [
      "Self hugging"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01796",
    "question": "What is associated with Elevated circulating guanidinoacetic acid concentration?",
    "seeds": [
      "Elevated circulating guanidinoacetic acid concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01797",
    "question": "What is associated with Duodenal polyposis?",
    "seeds": [
      "Duodenal polyposis"
    ],
    "gold_answer": "Intestinal polyposis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01798",
    "question": "What is associated with Postencephalitic parkinsonism?",
    "seeds": [
      "Postencephalitic parkinsonism"
    ],
    "gold_answer": "Vertical supranuclear gaze palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01799",
    "question": "What is associated with Parietal cortical atrophy?",
    "seeds": [
      "Parietal cortical atrophy"
    ],
    "gold_answer": "Cerebral atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01800",
    "question": "What is associated with Pacman dysplasia?",
    "seeds": [
      "Pacman dysplasia"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01801",
    "question": "What is associated with Increased fucosylation of N-linked protein glycosylation?",
    "seeds": [
      "Increased fucosylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01802",
    "question": "What is associated with Hypoalbuminemia?",
    "seeds": [
      "Hypoalbuminemia"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01803",
    "question": "What is associated with Posterior subluxation of radial head?",
    "seeds": [
      "Posterior subluxation of radial head"
    ],
    "gold_answer": "Joint subluxation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01804",
    "question": "What is associated with Anterior synechiae of the anterior chamber?",
    "seeds": [
      "Anterior synechiae of the anterior chamber"
    ],
    "gold_answer": "Abnormal anterior chamber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01805",
    "question": "What is associated with Typhoid?",
    "seeds": [
      "Typhoid"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01806",
    "question": "What is associated with Pituitary hormone deficiency, combined, 1?",
    "seeds": [
      "Pituitary hormone deficiency, combined, 1"
    ],
    "gold_answer": "Abnormality of the voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01807",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 33?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 33"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01808",
    "question": "What is associated with Curved middle phalanx of the 4th finger?",
    "seeds": [
      "Curved middle phalanx of the 4th finger"
    ],
    "gold_answer": "Curved fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01809",
    "question": "What is associated with Hoyeraal-Hreidarsson syndrome?",
    "seeds": [
      "Hoyeraal-Hreidarsson syndrome"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01810",
    "question": "What is associated with Global mesangial sclerosis?",
    "seeds": [
      "Global mesangial sclerosis"
    ],
    "gold_answer": "Abnormal glomerular mesangial matrix morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01811",
    "question": "What is associated with Absent vertebral body mineralization?",
    "seeds": [
      "Absent vertebral body mineralization"
    ],
    "gold_answer": "Abnormally ossified vertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01812",
    "question": "What is associated with Muscular dystrophy, limb-girdle, autosomal recessive 29?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, autosomal recessive 29"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01813",
    "question": "What is associated with Familial progressive retinal dystrophy-iris coloboma-congenital cataract syndrome?",
    "seeds": [
      "Familial progressive retinal dystrophy-iris coloboma-congenital cataract syndrome"
    ],
    "gold_answer": "MIR204",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_test_01814",
    "question": "What phenotype is associated with Retinal capillary malformation?",
    "seeds": [
      "Retinal capillary malformation"
    ],
    "gold_answer": "Cerebellar edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01815",
    "question": "What is associated with Hepatic sinusoidal dilatation?",
    "seeds": [
      "Hepatic sinusoidal dilatation"
    ],
    "gold_answer": "Abnormal liver parenchyma morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01816",
    "question": "What is associated with Spinal muscular atrophy, distal, X-linked 3?",
    "seeds": [
      "Spinal muscular atrophy, distal, X-linked 3"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01817",
    "question": "What phenotype is associated with X-linked dominant chondrodysplasia punctata?",
    "seeds": [
      "X-linked dominant chondrodysplasia punctata"
    ],
    "gold_answer": "Proteinuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01818",
    "question": "What is associated with Abnormal blood monovalent inorganic cation concentration?",
    "seeds": [
      "Abnormal blood monovalent inorganic cation concentration"
    ],
    "gold_answer": "Abnormal blood ion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01819",
    "question": "What is associated with CHOPS syndrome?",
    "seeds": [
      "CHOPS syndrome"
    ],
    "gold_answer": "Facial hypertrichosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01820",
    "question": "What is associated with Steroid dehydrogenase deficiency-dental anomalies syndrome?",
    "seeds": [
      "Steroid dehydrogenase deficiency-dental anomalies syndrome"
    ],
    "gold_answer": "Abnormal dental enamel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01821",
    "question": "What is associated with Finger dactylitis?",
    "seeds": [
      "Finger dactylitis"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01822",
    "question": "What phenotype is associated with Polycystic liver disease 3 with or without kidney cysts?",
    "seeds": [
      "Polycystic liver disease 3 with or without kidney cysts"
    ],
    "gold_answer": "Renal cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01823",
    "question": "What is associated with Abnormality of the middle phalanx of the 5th finger?",
    "seeds": [
      "Abnormality of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01824",
    "question": "What phenotype is associated with Bethlem myopathy 2?",
    "seeds": [
      "Bethlem myopathy 2"
    ],
    "gold_answer": "Elevated circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01825",
    "question": "What is associated with Closed neural tube defect?",
    "seeds": [
      "Closed neural tube defect"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01826",
    "question": "What is associated with Shoulder dystocia?",
    "seeds": [
      "Shoulder dystocia"
    ],
    "gold_answer": "Abnormal delivery",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01827",
    "question": "What is associated with Pulmonary chondroma?",
    "seeds": [
      "Pulmonary chondroma"
    ],
    "gold_answer": "Neoplasm of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01828",
    "question": "What is associated with Joint contracture of the 3rd finger?",
    "seeds": [
      "Joint contracture of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01829",
    "question": "What is associated with Anticardiolipin IgG antibody positivity?",
    "seeds": [
      "Anticardiolipin IgG antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01830",
    "question": "What is associated with Hypercalciuria?",
    "seeds": [
      "Hypercalciuria"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01831",
    "question": "What is associated with Abnormal right atrium morphology?",
    "seeds": [
      "Abnormal right atrium morphology"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01832",
    "question": "What is associated with Tremor?",
    "seeds": [
      "Tremor"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01833",
    "question": "What is associated with Rectal arteriovenous malformation?",
    "seeds": [
      "Rectal arteriovenous malformation"
    ],
    "gold_answer": "Gastrointestinal arteriovenous malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01834",
    "question": "What is associated with Increased circulating interleukin 17A concentration?",
    "seeds": [
      "Increased circulating interleukin 17A concentration"
    ],
    "gold_answer": "Abnormal circulating interleukin 17A concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01835",
    "question": "What phenotype is associated with Mitochondrial complex I deficiency, nuclear type 21?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 21"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01836",
    "question": "What is associated with Anti-tyrosine phosphatase region of islet antigen-2 antibody positivity?",
    "seeds": [
      "Anti-tyrosine phosphatase region of islet antigen-2 antibody positivity"
    ],
    "gold_answer": "Anti-islet antigen-2 antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01837",
    "question": "What is associated with Absent hair?",
    "seeds": [
      "Absent hair"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01838",
    "question": "What phenotype is associated with Autosomal dominant polycystic kidney disease?",
    "seeds": [
      "Autosomal dominant polycystic kidney disease"
    ],
    "gold_answer": "Spinal cord compression",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01839",
    "question": "What is associated with Spastic paraplegia 18, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 18, autosomal recessive"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01840",
    "question": "What is associated with Amyotrophy involving the shoulder musculature?",
    "seeds": [
      "Amyotrophy involving the shoulder musculature"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01841",
    "question": "What is associated with Thoracopelvic dysostosis?",
    "seeds": [
      "Thoracopelvic dysostosis"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01842",
    "question": "What is associated with Late infantile CLN2 disease?",
    "seeds": [
      "Late infantile CLN2 disease"
    ],
    "gold_answer": "TPP1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01843",
    "question": "What is associated with Autosomal recessive myosin storage myopathy?",
    "seeds": [
      "Autosomal recessive myosin storage myopathy"
    ],
    "gold_answer": "MYH7",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01844",
    "question": "What is associated with Bare lymphocyte syndrome, type I?",
    "seeds": [
      "Bare lymphocyte syndrome, type I"
    ],
    "gold_answer": "Otitis media",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01845",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 8?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 8"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01846",
    "question": "What is associated with Aberrant melanosome maturation?",
    "seeds": [
      "Aberrant melanosome maturation"
    ],
    "gold_answer": "Abnormality of dermal melanosomes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01847",
    "question": "What is associated with Abnormal circulating neopterin concentration?",
    "seeds": [
      "Abnormal circulating neopterin concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01848",
    "question": "What is associated with Naegeli-Franceschetti-Jadassohn syndrome?",
    "seeds": [
      "Naegeli-Franceschetti-Jadassohn syndrome"
    ],
    "gold_answer": "KRT14",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01849",
    "question": "What is associated with Triangular shaped phalanges of the 3rd toe?",
    "seeds": [
      "Triangular shaped phalanges of the 3rd toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01850",
    "question": "What is associated with Y-shaped metacarpals?",
    "seeds": [
      "Y-shaped metacarpals"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01851",
    "question": "What is associated with Abnormal emotional state?",
    "seeds": [
      "Abnormal emotional state"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01852",
    "question": "What is associated with Focal impaired awareness sensory seizure with visual features?",
    "seeds": [
      "Focal impaired awareness sensory seizure with visual features"
    ],
    "gold_answer": "Focal impaired awareness non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01853",
    "question": "What is associated with Abnormal Langerhans cell morphology?",
    "seeds": [
      "Abnormal Langerhans cell morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01854",
    "question": "What is associated with Angioedema, hereditary, 7?",
    "seeds": [
      "Angioedema, hereditary, 7"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01855",
    "question": "What is associated with Aplasia/Hypoplasia of the ribs?",
    "seeds": [
      "Aplasia/Hypoplasia of the ribs"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01856",
    "question": "What phenotype is associated with Hypothyroidism, congenital, nongoitrous, 4?",
    "seeds": [
      "Hypothyroidism, congenital, nongoitrous, 4"
    ],
    "gold_answer": "Umbilical hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01857",
    "question": "What is associated with Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay?",
    "seeds": [
      "Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01858",
    "question": "What is associated with Hypnagogic sleep paralysis?",
    "seeds": [
      "Hypnagogic sleep paralysis"
    ],
    "gold_answer": "Abnormal rapid eye movement sleep",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01859",
    "question": "What is associated with Psychosis?",
    "seeds": [
      "Psychosis"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01860",
    "question": "What is associated with Abnormal total iron binding capacity?",
    "seeds": [
      "Abnormal total iron binding capacity"
    ],
    "gold_answer": "Abnormal blood transition element cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01861",
    "question": "What is associated with Adermatoglyphia?",
    "seeds": [
      "Adermatoglyphia"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01862",
    "question": "What is associated with Deafness, autosomal dominant 89?",
    "seeds": [
      "Deafness, autosomal dominant 89"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01863",
    "question": "What is associated with Stippling of the epiphysis of the 1st metatarsal?",
    "seeds": [
      "Stippling of the epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01864",
    "question": "What is associated with Oral melanoacanthoma?",
    "seeds": [
      "Oral melanoacanthoma"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01865",
    "question": "What is associated with Proteinuria?",
    "seeds": [
      "Proteinuria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01866",
    "question": "What is associated with Cerebral palsy, ataxic, autosomal recessive?",
    "seeds": [
      "Cerebral palsy, ataxic, autosomal recessive"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01867",
    "question": "What is associated with Trichothiodystrophy 9, nonphotosensitive?",
    "seeds": [
      "Trichothiodystrophy 9, nonphotosensitive"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01868",
    "question": "What is associated with Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia?",
    "seeds": [
      "Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia"
    ],
    "gold_answer": "Internal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01869",
    "question": "What is associated with Bronchial stenosis?",
    "seeds": [
      "Bronchial stenosis"
    ],
    "gold_answer": "Abnormal bronchus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01870",
    "question": "What is associated with Palatal edema?",
    "seeds": [
      "Palatal edema"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01871",
    "question": "What phenotype is associated with Acrofacial dysostosis, Cincinnati type?",
    "seeds": [
      "Acrofacial dysostosis, Cincinnati type"
    ],
    "gold_answer": "Spinal cord tumor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01872",
    "question": "What phenotype is associated with Deafness, autosomal recessive 33?",
    "seeds": [
      "Deafness, autosomal recessive 33"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01873",
    "question": "What is associated with Musk, inability to smell?",
    "seeds": [
      "Musk, inability to smell"
    ],
    "gold_answer": "Abnormality of the sense of smell",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01874",
    "question": "What is associated with Abnormal cerebral cortex morphology?",
    "seeds": [
      "Abnormal cerebral cortex morphology"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01875",
    "question": "What is associated with Sensory axonal neuropathy?",
    "seeds": [
      "Sensory axonal neuropathy"
    ],
    "gold_answer": "Peripheral axonal neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01876",
    "question": "What is associated with Prominent protruding coccyx?",
    "seeds": [
      "Prominent protruding coccyx"
    ],
    "gold_answer": "Abnormal coccyx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01877",
    "question": "What is associated with Decreased circulating dihydrotestosterone concentration?",
    "seeds": [
      "Decreased circulating dihydrotestosterone concentration"
    ],
    "gold_answer": "Decreased circulating androgen concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01878",
    "question": "What is associated with DNM1L-related encephalopathy due to mitochondrial and peroxisomal fission defect?",
    "seeds": [
      "DNM1L-related encephalopathy due to mitochondrial and peroxisomal fission defect"
    ],
    "gold_answer": "DNM1L",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_test_01879",
    "question": "What is associated with Cleft lip/palate?",
    "seeds": [
      "Cleft lip/palate"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01880",
    "question": "What is associated with Large knee?",
    "seeds": [
      "Large knee"
    ],
    "gold_answer": "Abnormal knee morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01881",
    "question": "What is associated with Irregular epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Irregular epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01882",
    "question": "What is associated with Hallux plantarflexion weakness?",
    "seeds": [
      "Hallux plantarflexion weakness"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01883",
    "question": "What phenotype is associated with Pseudoaminopterin syndrome?",
    "seeds": [
      "Pseudoaminopterin syndrome"
    ],
    "gold_answer": "Poor suck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01884",
    "question": "What is associated with Enterocutaneous fistula?",
    "seeds": [
      "Enterocutaneous fistula"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01885",
    "question": "What is associated with Short distal phalanx of hallux?",
    "seeds": [
      "Short distal phalanx of hallux"
    ],
    "gold_answer": "Short phalanx of hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01886",
    "question": "What phenotype is associated with Prader-Willi syndrome due to translocation?",
    "seeds": [
      "Prader-Willi syndrome due to translocation"
    ],
    "gold_answer": "Submucous cleft soft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01887",
    "question": "What is associated with TOR1AIP1-related limb-girdle muscular dystrophy?",
    "seeds": [
      "TOR1AIP1-related limb-girdle muscular dystrophy"
    ],
    "gold_answer": "TOR1AIP1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_test_01888",
    "question": "What is associated with Bipartite calcaneus?",
    "seeds": [
      "Bipartite calcaneus"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01889",
    "question": "What is associated with Sclerosis of hand bone?",
    "seeds": [
      "Sclerosis of hand bone"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01890",
    "question": "What is associated with Osteogenesis imperfecta type 4?",
    "seeds": [
      "Osteogenesis imperfecta type 4"
    ],
    "gold_answer": "TMEM38B",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01891",
    "question": "What is associated with Orchitis?",
    "seeds": [
      "Orchitis"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01892",
    "question": "What is associated with Fatal congenital hypertrophic cardiomyopathy due to glycogen storage disease?",
    "seeds": [
      "Fatal congenital hypertrophic cardiomyopathy due to glycogen storage disease"
    ],
    "gold_answer": "PRKAG2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01893",
    "question": "What is associated with Omovertebral bone?",
    "seeds": [
      "Omovertebral bone"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01894",
    "question": "What is associated with Morbus Koehler?",
    "seeds": [
      "Morbus Koehler"
    ],
    "gold_answer": "Juvenile aseptic necrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01895",
    "question": "What is associated with Immunodeficiency 63 with lymphoproliferation and autoimmunity?",
    "seeds": [
      "Immunodeficiency 63 with lymphoproliferation and autoimmunity"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01896",
    "question": "What is associated with Triangular shaped proximal phalanx of the 3rd finger?",
    "seeds": [
      "Triangular shaped proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01897",
    "question": "What is associated with Spastic paraplegia 20, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 20, autosomal recessive"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01898",
    "question": "What is associated with Abnormal chorioretinal morphology?",
    "seeds": [
      "Abnormal chorioretinal morphology"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01899",
    "question": "What is associated with Coronary cameral fistula?",
    "seeds": [
      "Coronary cameral fistula"
    ],
    "gold_answer": "Abnormal coronary artery course",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01900",
    "question": "What phenotype is associated with Van Maldergem syndrome 1?",
    "seeds": [
      "Van Maldergem syndrome 1"
    ],
    "gold_answer": "Short clavicles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01901",
    "question": "What is associated with Diplopia?",
    "seeds": [
      "Diplopia"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01902",
    "question": "What is associated with Shortening of all phalanges of the toes?",
    "seeds": [
      "Shortening of all phalanges of the toes"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01903",
    "question": "What is associated with Periorbital purpura?",
    "seeds": [
      "Periorbital purpura"
    ],
    "gold_answer": "Abnormality of the periorbital region",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01904",
    "question": "What is associated with Positive Finkelstein sign?",
    "seeds": [
      "Positive Finkelstein sign"
    ],
    "gold_answer": "Abnormality of the wrist",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01905",
    "question": "What is associated with Dermatosis papulosa nigra?",
    "seeds": [
      "Dermatosis papulosa nigra"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01906",
    "question": "What is associated with Periportal emperipolesis?",
    "seeds": [
      "Periportal emperipolesis"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01907",
    "question": "What is associated with Familial generalized lentiginosis?",
    "seeds": [
      "Familial generalized lentiginosis"
    ],
    "gold_answer": "SASH1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01908",
    "question": "What is associated with C2-C3 subluxation?",
    "seeds": [
      "C2-C3 subluxation"
    ],
    "gold_answer": "Abnormality of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01909",
    "question": "What is associated with Remote trauma history?",
    "seeds": [
      "Remote trauma history"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01910",
    "question": "What is associated with Interlobular vein medial atrophy?",
    "seeds": [
      "Interlobular vein medial atrophy"
    ],
    "gold_answer": "Abnormal interlobular vein intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01911",
    "question": "What is associated with Sneeze?",
    "seeds": [
      "Sneeze"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01912",
    "question": "What is associated with Patchy sclerosis of 3rd finger phalanx?",
    "seeds": [
      "Patchy sclerosis of 3rd finger phalanx"
    ],
    "gold_answer": "Increased bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01913",
    "question": "What is associated with Spondylolysis?",
    "seeds": [
      "Spondylolysis"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01914",
    "question": "What phenotype is associated with Isolated congenital hypoglossia/aglossia?",
    "seeds": [
      "Isolated congenital hypoglossia/aglossia"
    ],
    "gold_answer": "Cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01915",
    "question": "What is associated with Shoulder pain?",
    "seeds": [
      "Shoulder pain"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01916",
    "question": "What is associated with Urethral diverticulum?",
    "seeds": [
      "Urethral diverticulum"
    ],
    "gold_answer": "Abnormality of the lower urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01917",
    "question": "What phenotype is associated with Short chain acyl-CoA dehydrogenase deficiency?",
    "seeds": [
      "Short chain acyl-CoA dehydrogenase deficiency"
    ],
    "gold_answer": "Myopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01918",
    "question": "What phenotype is associated with Corpus callosum agenesis-neuronopathy syndrome?",
    "seeds": [
      "Corpus callosum agenesis-neuronopathy syndrome"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01919",
    "question": "What is associated with Agammaglobulinemia 9, autosomal recessive?",
    "seeds": [
      "Agammaglobulinemia 9, autosomal recessive"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01920",
    "question": "What is associated with Ataxia, deafness, and cardiomyopathy?",
    "seeds": [
      "Ataxia, deafness, and cardiomyopathy"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01921",
    "question": "What is associated with Spondylometaphyseal dysplasia, X-linked?",
    "seeds": [
      "Spondylometaphyseal dysplasia, X-linked"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01922",
    "question": "What is associated with Shield chest?",
    "seeds": [
      "Shield chest"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01923",
    "question": "What is associated with Anemia, congenital dyserythropoietic, type Ia?",
    "seeds": [
      "Anemia, congenital dyserythropoietic, type Ia"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01924",
    "question": "What is associated with High, narrow palate?",
    "seeds": [
      "High, narrow palate"
    ],
    "gold_answer": "Narrow palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01925",
    "question": "What is associated with Congenital disorder of glycosylation, type Ia?",
    "seeds": [
      "Congenital disorder of glycosylation, type Ia"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01926",
    "question": "What is associated with Prenatal-onset spinal muscular atrophy with congenital bone fractures?",
    "seeds": [
      "Prenatal-onset spinal muscular atrophy with congenital bone fractures"
    ],
    "gold_answer": "ASCC1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01927",
    "question": "What is associated with Triggered by sodium ingestion?",
    "seeds": [
      "Triggered by sodium ingestion"
    ],
    "gold_answer": "Triggered by food ingestion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01928",
    "question": "What is associated with Pulmonary hamartoma?",
    "seeds": [
      "Pulmonary hamartoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01929",
    "question": "What is associated with Absent styloid process of ulna?",
    "seeds": [
      "Absent styloid process of ulna"
    ],
    "gold_answer": "Abnormal morphology of ulna",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01930",
    "question": "What is associated with Thrombophilia, hereditary, due to protein S deficiency, autosomal?",
    "seeds": [
      "Thrombophilia, hereditary, due to protein S deficiency, autosomal"
    ],
    "gold_answer": "Thrombophlebitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01931",
    "question": "What is associated with Skin rash?",
    "seeds": [
      "Skin rash"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01932",
    "question": "What is associated with Symmetric distribution?",
    "seeds": [
      "Symmetric distribution"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01933",
    "question": "What is associated with Dense posterior cortical cataract?",
    "seeds": [
      "Dense posterior cortical cataract"
    ],
    "gold_answer": "Posterior cortical cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01934",
    "question": "What phenotype is associated with Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities?",
    "seeds": [
      "Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities"
    ],
    "gold_answer": "Long penis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01935",
    "question": "What is associated with Alpha-gal allergy?",
    "seeds": [
      "Alpha-gal allergy"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01936",
    "question": "What phenotype is associated with Myelolymphatic insufficiency?",
    "seeds": [
      "Myelolymphatic insufficiency"
    ],
    "gold_answer": "Recurrent bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01937",
    "question": "What is associated with Absent retinal pigment epithelium?",
    "seeds": [
      "Absent retinal pigment epithelium"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01938",
    "question": "What is associated with Ullrich congenital muscular dystrophy 1B?",
    "seeds": [
      "Ullrich congenital muscular dystrophy 1B"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01939",
    "question": "What is associated with Elevated circulating glycolate concentration?",
    "seeds": [
      "Elevated circulating glycolate concentration"
    ],
    "gold_answer": "Abnormal circulating monocarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01940",
    "question": "What phenotype is associated with Post-transplant lymphoproliferative disease?",
    "seeds": [
      "Post-transplant lymphoproliferative disease"
    ],
    "gold_answer": "Fever",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01941",
    "question": "What is associated with Synostosis involving the 1st metatarsal?",
    "seeds": [
      "Synostosis involving the 1st metatarsal"
    ],
    "gold_answer": "Abnormality of the first metatarsal bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01942",
    "question": "What is associated with Elevated urinary N-tau-ribosylhistidine level?",
    "seeds": [
      "Elevated urinary N-tau-ribosylhistidine level"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01943",
    "question": "What is associated with Hypertaurinemia?",
    "seeds": [
      "Hypertaurinemia"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01944",
    "question": "What is associated with Bardet-Biedl syndrome 8?",
    "seeds": [
      "Bardet-Biedl syndrome 8"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01945",
    "question": "What is associated with Glomerular basement membrane spikes?",
    "seeds": [
      "Glomerular basement membrane spikes"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01946",
    "question": "What phenotype is associated with Corneal dystrophy, punctiform and polychromatic pre-Descemet?",
    "seeds": [
      "Corneal dystrophy, punctiform and polychromatic pre-Descemet"
    ],
    "gold_answer": "Posterior corneal stroma punctiform multicolored opacities",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01947",
    "question": "What phenotype is associated with Immunodeficiency 16?",
    "seeds": [
      "Immunodeficiency 16"
    ],
    "gold_answer": "Immunodeficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01948",
    "question": "What is associated with Body mass index quantitative trait locus 20?",
    "seeds": [
      "Body mass index quantitative trait locus 20"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01949",
    "question": "What phenotype is associated with Developmental delay, hypotonia, and impaired language?",
    "seeds": [
      "Developmental delay, hypotonia, and impaired language"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01950",
    "question": "What phenotype is associated with Intrauterine growth retardation with increased mitomycin C sensitivity?",
    "seeds": [
      "Intrauterine growth retardation with increased mitomycin C sensitivity"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01951",
    "question": "What phenotype is associated with Hypoparathyroidism, familial isolated 2?",
    "seeds": [
      "Hypoparathyroidism, familial isolated 2"
    ],
    "gold_answer": "Hyperphosphatemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01952",
    "question": "What is associated with Albinism, oculocutaneous, type III?",
    "seeds": [
      "Albinism, oculocutaneous, type III"
    ],
    "gold_answer": "Abnormality of hair pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01953",
    "question": "What is associated with Spinal muscular atrophy, type I?",
    "seeds": [
      "Spinal muscular atrophy, type I"
    ],
    "gold_answer": "Prenatal movement abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01954",
    "question": "What is associated with Elevated urinary isovalerylglycine level?",
    "seeds": [
      "Elevated urinary isovalerylglycine level"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01955",
    "question": "What is associated with Amyotrophy, monomelic?",
    "seeds": [
      "Amyotrophy, monomelic"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01956",
    "question": "What is associated with C11ORF73-related autosomal recessive hypomyelinating leukodystrophy?",
    "seeds": [
      "C11ORF73-related autosomal recessive hypomyelinating leukodystrophy"
    ],
    "gold_answer": "HIKESHI",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_01957",
    "question": "What phenotype is associated with Atrial septal defect, ostium primum type?",
    "seeds": [
      "Atrial septal defect, ostium primum type"
    ],
    "gold_answer": "Atrioventricular block",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01958",
    "question": "What is associated with Collagenosis, familial reactive perforating?",
    "seeds": [
      "Collagenosis, familial reactive perforating"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01959",
    "question": "What is associated with Personality disorder?",
    "seeds": [
      "Personality disorder"
    ],
    "gold_answer": "Impairment in personality functioning",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01960",
    "question": "What is associated with Accelerated atherosclerosis?",
    "seeds": [
      "Accelerated atherosclerosis"
    ],
    "gold_answer": "Atherosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01961",
    "question": "What is associated with Enlarged epiphysis of the distal phalanx of the 5th finger?",
    "seeds": [
      "Enlarged epiphysis of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the distal phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01962",
    "question": "What is associated with Pelvic dysplasia-arthrogryposis of lower limbs syndrome?",
    "seeds": [
      "Pelvic dysplasia-arthrogryposis of lower limbs syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01963",
    "question": "What is associated with Excessive wrinkled skin?",
    "seeds": [
      "Excessive wrinkled skin"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01964",
    "question": "What is associated with Brachymorphism-Onychodysplasia-Dysphalangism syndrome?",
    "seeds": [
      "Brachymorphism-Onychodysplasia-Dysphalangism syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the nails",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01965",
    "question": "What is associated with Pemphigus foliaceus?",
    "seeds": [
      "Pemphigus foliaceus"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01966",
    "question": "What is associated with Narrow philtrum?",
    "seeds": [
      "Narrow philtrum"
    ],
    "gold_answer": "Abnormality of the philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01967",
    "question": "What is associated with Corneal scarring?",
    "seeds": [
      "Corneal scarring"
    ],
    "gold_answer": "Scarring",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01968",
    "question": "What is associated with Chromosomal breakage induced by crosslinking agents?",
    "seeds": [
      "Chromosomal breakage induced by crosslinking agents"
    ],
    "gold_answer": "Abnormality of chromosome stability",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01969",
    "question": "What is associated with Elevated urinary 2-methyl-3-hydroxybutyric acid level?",
    "seeds": [
      "Elevated urinary 2-methyl-3-hydroxybutyric acid level"
    ],
    "gold_answer": "Increased urine proteinogenic amino acid derivative level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01970",
    "question": "What is associated with GONADOBLASTOMA?",
    "seeds": [
      "GONADOBLASTOMA"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01971",
    "question": "What is associated with Tapered sperm head?",
    "seeds": [
      "Tapered sperm head"
    ],
    "gold_answer": "Abnormal male germ cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01972",
    "question": "What is associated with Prosopagnosia, hereditary?",
    "seeds": [
      "Prosopagnosia, hereditary"
    ],
    "gold_answer": "Disturbed sensory perception",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01973",
    "question": "What is associated with Abnormal renal tubule morphology?",
    "seeds": [
      "Abnormal renal tubule morphology"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01974",
    "question": "What is associated with Iliac arterial calcification?",
    "seeds": [
      "Iliac arterial calcification"
    ],
    "gold_answer": "Peripheral arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01975",
    "question": "What phenotype is associated with Monomelic amyotrophy?",
    "seeds": [
      "Monomelic amyotrophy"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01976",
    "question": "What is associated with Abnormal nasal morphology?",
    "seeds": [
      "Abnormal nasal morphology"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01977",
    "question": "What is associated with Positive urine cocaine test?",
    "seeds": [
      "Positive urine cocaine test"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01978",
    "question": "What is associated with Alternating hypertropia?",
    "seeds": [
      "Alternating hypertropia"
    ],
    "gold_answer": "Hyperdeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01979",
    "question": "What phenotype is associated with Hemorrhagic destruction of the brain, subependymal calcification,and cataracts?",
    "seeds": [
      "Hemorrhagic destruction of the brain, subependymal calcification,and cataracts"
    ],
    "gold_answer": "Ventricular septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01980",
    "question": "What is associated with Increased lymph-node cellular CD20 expression?",
    "seeds": [
      "Increased lymph-node cellular CD20 expression"
    ],
    "gold_answer": "Abnormal level of lymph-node cellular CD20 expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01981",
    "question": "What is associated with Phelan-McDermid syndrome due to SHANK3 mutation?",
    "seeds": [
      "Phelan-McDermid syndrome due to SHANK3 mutation"
    ],
    "gold_answer": "SHANK3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_test_01982",
    "question": "What is associated with Anterior chamber inflammatory cells?",
    "seeds": [
      "Anterior chamber inflammatory cells"
    ],
    "gold_answer": "Abnormal anterior chamber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01983",
    "question": "What is associated with Abnormal peritubular capillary morphology?",
    "seeds": [
      "Abnormal peritubular capillary morphology"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01984",
    "question": "What phenotype is associated with Split-Hand/foot malformation 4?",
    "seeds": [
      "Split-Hand/foot malformation 4"
    ],
    "gold_answer": "Split hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_01985",
    "question": "What is associated with Right ventricular cardiomyopathy?",
    "seeds": [
      "Right ventricular cardiomyopathy"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01986",
    "question": "What is associated with Ureteral duplication?",
    "seeds": [
      "Ureteral duplication"
    ],
    "gold_answer": "Abnormality of the ureter",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01987",
    "question": "What is associated with Aplasia/Hypoplasia of the ribs?",
    "seeds": [
      "Aplasia/Hypoplasia of the ribs"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01988",
    "question": "What is associated with Post-vaccination yellow fever?",
    "seeds": [
      "Post-vaccination yellow fever"
    ],
    "gold_answer": "Infection following live vaccination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01989",
    "question": "What is associated with Abnormality of von Willebrand factor?",
    "seeds": [
      "Abnormality of von Willebrand factor"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01990",
    "question": "What is associated with Scapuloperoneal myopathy?",
    "seeds": [
      "Scapuloperoneal myopathy"
    ],
    "gold_answer": "Abnormal calf musculature morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01991",
    "question": "What is associated with Dahlberg-Borer-Newcomer syndrome?",
    "seeds": [
      "Dahlberg-Borer-Newcomer syndrome"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01992",
    "question": "What is associated with Intestinal dysmotility syndrome?",
    "seeds": [
      "Intestinal dysmotility syndrome"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01993",
    "question": "What is associated with Disturbed sensory perception?",
    "seeds": [
      "Disturbed sensory perception"
    ],
    "gold_answer": "Disturbed perception with a stimulus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01994",
    "question": "What is associated with Calcification of cartilage?",
    "seeds": [
      "Calcification of cartilage"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01995",
    "question": "What is associated with Slit-like opening of the exterior auditory meatus?",
    "seeds": [
      "Slit-like opening of the exterior auditory meatus"
    ],
    "gold_answer": "Stenosis of the external auditory canal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01996",
    "question": "What is associated with Recurrent Staphylococcus aureus infections?",
    "seeds": [
      "Recurrent Staphylococcus aureus infections"
    ],
    "gold_answer": "Recurrent staphylococcal infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01997",
    "question": "What is associated with Increased level of galactitol in urine?",
    "seeds": [
      "Increased level of galactitol in urine"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01998",
    "question": "What is associated with Respiratory infections in early life?",
    "seeds": [
      "Respiratory infections in early life"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_01999",
    "question": "What phenotype is associated with Syndromic X-linked intellectual disability 7?",
    "seeds": [
      "Syndromic X-linked intellectual disability 7"
    ],
    "gold_answer": "Visual loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02000",
    "question": "What is associated with Oral mucosal blisters?",
    "seeds": [
      "Oral mucosal blisters"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02001",
    "question": "What is associated with Jung syndrome?",
    "seeds": [
      "Jung syndrome"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02002",
    "question": "What is associated with X-linked severe congenital neutropenia?",
    "seeds": [
      "X-linked severe congenital neutropenia"
    ],
    "gold_answer": "Abnormal total neutrophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02003",
    "question": "What phenotype is associated with Mitochondrial complex I deficiency, nuclear type 11?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 11"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02004",
    "question": "What is associated with Uterine cyst?",
    "seeds": [
      "Uterine cyst"
    ],
    "gold_answer": "Abnormal uterus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02005",
    "question": "What phenotype is associated with Mucolipidosis type II?",
    "seeds": [
      "Mucolipidosis type II"
    ],
    "gold_answer": "Oligohydramnios",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02006",
    "question": "What is associated with Ring chromosome 11 syndrome?",
    "seeds": [
      "Ring chromosome 11 syndrome"
    ],
    "gold_answer": "Abnormal renal pelvis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02007",
    "question": "What is associated with Anti-GW182 antibody positivity?",
    "seeds": [
      "Anti-GW182 antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02008",
    "question": "What is associated with Preauricular lymphadenopathy?",
    "seeds": [
      "Preauricular lymphadenopathy"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02009",
    "question": "What is associated with Absent dermal elastic fibers?",
    "seeds": [
      "Absent dermal elastic fibers"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02010",
    "question": "What is associated with Atherosclerotic lesion?",
    "seeds": [
      "Atherosclerotic lesion"
    ],
    "gold_answer": "Arteriosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02011",
    "question": "What is associated with Neutropenia, severe congenital 3, autosomal recessive?",
    "seeds": [
      "Neutropenia, severe congenital 3, autosomal recessive"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02012",
    "question": "What is associated with Perisylvian FDG hypermetabolism?",
    "seeds": [
      "Perisylvian FDG hypermetabolism"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02013",
    "question": "What is associated with 8q12 microduplication syndrome?",
    "seeds": [
      "8q12 microduplication syndrome"
    ],
    "gold_answer": "Abnormal size of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02014",
    "question": "What is associated with Elevated circulating insulin:C-peptide ratio?",
    "seeds": [
      "Elevated circulating insulin:C-peptide ratio"
    ],
    "gold_answer": "Abnormal circulating insulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02015",
    "question": "What is associated with Tricuspid valve prolapse?",
    "seeds": [
      "Tricuspid valve prolapse"
    ],
    "gold_answer": "Abnormal heart valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02016",
    "question": "What is associated with Osteolytic defects of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Osteolytic defects of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Osteolytic defects of the phalanges of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02017",
    "question": "What is associated with Fractured scapula?",
    "seeds": [
      "Fractured scapula"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02018",
    "question": "What is associated with Anomalous origin of the right common carotid artery from the aorta?",
    "seeds": [
      "Anomalous origin of the right common carotid artery from the aorta"
    ],
    "gold_answer": "Abnormal carotid artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02019",
    "question": "What is associated with Fractured carpal bone?",
    "seeds": [
      "Fractured carpal bone"
    ],
    "gold_answer": "Abnormal carpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02020",
    "question": "What is associated with Impaired intellectual development, truncal obesity, retinal dystrophy, and micropenis syndrome?",
    "seeds": [
      "Impaired intellectual development, truncal obesity, retinal dystrophy, and micropenis syndrome"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02021",
    "question": "What is associated with Intellectual developmental disorder, X-linked syndromic 33?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic 33"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02022",
    "question": "What is associated with Aseptic abscess syndrome?",
    "seeds": [
      "Aseptic abscess syndrome"
    ],
    "gold_answer": "Abnormal external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02023",
    "question": "What is associated with Recurrent upper and lower respiratory tract infections?",
    "seeds": [
      "Recurrent upper and lower respiratory tract infections"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02024",
    "question": "What is associated with Abnormality of cervical plexus?",
    "seeds": [
      "Abnormality of cervical plexus"
    ],
    "gold_answer": "Abnormality of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02025",
    "question": "What is associated with Triggered by sodium ingestion?",
    "seeds": [
      "Triggered by sodium ingestion"
    ],
    "gold_answer": "Triggered by food ingestion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02026",
    "question": "What is associated with Chondroblastoma?",
    "seeds": [
      "Chondroblastoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02027",
    "question": "What is associated with Endocrine-cerebro-osteodysplasia syndrome?",
    "seeds": [
      "Endocrine-cerebro-osteodysplasia syndrome"
    ],
    "gold_answer": "CILK1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02028",
    "question": "What is associated with Shortening of all distal phalanges of the toes?",
    "seeds": [
      "Shortening of all distal phalanges of the toes"
    ],
    "gold_answer": "Short distal phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02029",
    "question": "What is associated with Keratoacanthoma?",
    "seeds": [
      "Keratoacanthoma"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02030",
    "question": "What phenotype is associated with Otosclerosis 12?",
    "seeds": [
      "Otosclerosis 12"
    ],
    "gold_answer": "Otosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02031",
    "question": "What is associated with Bronchomalacia?",
    "seeds": [
      "Bronchomalacia"
    ],
    "gold_answer": "Abnormal bronchus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02032",
    "question": "What is associated with HNRNPA1-related adult-onset distal myopathy?",
    "seeds": [
      "HNRNPA1-related adult-onset distal myopathy"
    ],
    "gold_answer": "HNRNPA1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02033",
    "question": "What is associated with Abnormal platelet membrane protein expression?",
    "seeds": [
      "Abnormal platelet membrane protein expression"
    ],
    "gold_answer": "Abnormality of thrombocytes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02034",
    "question": "What phenotype is associated with Anal canal carcinomacloacogenic carcinoma, included?",
    "seeds": [
      "Anal canal carcinomacloacogenic carcinoma, included"
    ],
    "gold_answer": "Anal canal squamous carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02035",
    "question": "What is associated with Abnormal Humphrey SITA 10-2 perimetry test?",
    "seeds": [
      "Abnormal Humphrey SITA 10-2 perimetry test"
    ],
    "gold_answer": "Abnormal static automated perimetry test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02036",
    "question": "What is associated with Diminished circulating hyaluronidase activity?",
    "seeds": [
      "Diminished circulating hyaluronidase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02037",
    "question": "What is associated with Elevated circulating tetradecanoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating tetradecanoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating long-chain acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02038",
    "question": "What is associated with Abnormal pituitary gland morphology?",
    "seeds": [
      "Abnormal pituitary gland morphology"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02039",
    "question": "What is associated with Cataract, autosomal dominant, multiple types 1?",
    "seeds": [
      "Cataract, autosomal dominant, multiple types 1"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02040",
    "question": "What is associated with Myopathy, distal, Tateyama type?",
    "seeds": [
      "Myopathy, distal, Tateyama type"
    ],
    "gold_answer": "Abnormal muscle fiber-type distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02041",
    "question": "What is associated with Pulmonary hypertension, primary, 7?",
    "seeds": [
      "Pulmonary hypertension, primary, 7"
    ],
    "gold_answer": "Atrial arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02042",
    "question": "What is associated with Unilateral microphthalmos?",
    "seeds": [
      "Unilateral microphthalmos"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02043",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 28?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 28"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02044",
    "question": "What is associated with Focal impaired awareness cognitive seizure with hallucination?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with hallucination"
    ],
    "gold_answer": "Focal impaired awareness cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02045",
    "question": "What is associated with Retinitis pigmentosa 46?",
    "seeds": [
      "Retinitis pigmentosa 46"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02046",
    "question": "What is associated with Neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination?",
    "seeds": [
      "Neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02047",
    "question": "What is associated with Hemoglobin H disease?",
    "seeds": [
      "Hemoglobin H disease"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02048",
    "question": "What phenotype is associated with Carney complex variant?",
    "seeds": [
      "Carney complex variant"
    ],
    "gold_answer": "Trismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02049",
    "question": "What is associated with Epiphyseal dysplasia-hearing loss-dysmorphism syndrome?",
    "seeds": [
      "Epiphyseal dysplasia-hearing loss-dysmorphism syndrome"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02050",
    "question": "What is associated with Decreased urinary copper concentration?",
    "seeds": [
      "Decreased urinary copper concentration"
    ],
    "gold_answer": "Abnormal urinary mineral level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02051",
    "question": "What is associated with Histiocytosis, progressive mucinous?",
    "seeds": [
      "Histiocytosis, progressive mucinous"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02052",
    "question": "What is associated with Archibald's sign?",
    "seeds": [
      "Archibald's sign"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02053",
    "question": "What is associated with Ring fibers?",
    "seeds": [
      "Ring fibers"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02054",
    "question": "What is associated with Decreased mitochondrial complex III activity in liver tissue?",
    "seeds": [
      "Decreased mitochondrial complex III activity in liver tissue"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02055",
    "question": "What is associated with Anomalous splenoportal venous system?",
    "seeds": [
      "Anomalous splenoportal venous system"
    ],
    "gold_answer": "Abnormality of the hepatic vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02056",
    "question": "What is associated with Cenani-Lenz syndactyly syndrome?",
    "seeds": [
      "Cenani-Lenz syndactyly syndrome"
    ],
    "gold_answer": "Abnormal zygomatic bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02057",
    "question": "What phenotype is associated with Breast-ovarian cancer, familial, susceptibility to, 5?",
    "seeds": [
      "Breast-ovarian cancer, familial, susceptibility to, 5"
    ],
    "gold_answer": "Breast carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02058",
    "question": "What is associated with Abnormal nonverbal communicative behavior?",
    "seeds": [
      "Abnormal nonverbal communicative behavior"
    ],
    "gold_answer": "Abnormal cognitive process",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02059",
    "question": "What is associated with AMME complex?",
    "seeds": [
      "AMME complex"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02060",
    "question": "What is associated with Cardiac lipidosis, familial?",
    "seeds": [
      "Cardiac lipidosis, familial"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02061",
    "question": "What is associated with Reduced circulating interleukin 7 concentration?",
    "seeds": [
      "Reduced circulating interleukin 7 concentration"
    ],
    "gold_answer": "Abnormal circulating interleukin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02062",
    "question": "What is associated with Glycogen storage disease due to phosphoglycerate mutase deficiency?",
    "seeds": [
      "Glycogen storage disease due to phosphoglycerate mutase deficiency"
    ],
    "gold_answer": "PGAM2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02063",
    "question": "What phenotype is associated with Shiga toxin-associated hemolytic uremic syndrome?",
    "seeds": [
      "Shiga toxin-associated hemolytic uremic syndrome"
    ],
    "gold_answer": "Coma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02064",
    "question": "What is associated with Elevated urinary collagen degradation products?",
    "seeds": [
      "Elevated urinary collagen degradation products"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02065",
    "question": "What is associated with Anteverted nares?",
    "seeds": [
      "Anteverted nares"
    ],
    "gold_answer": "Abnormal nostril morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02066",
    "question": "What is associated with Schwartz-Jampel syndrome?",
    "seeds": [
      "Schwartz-Jampel syndrome"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02067",
    "question": "What is associated with Digital ulcer?",
    "seeds": [
      "Digital ulcer"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02068",
    "question": "What is associated with Elevated urinary 2-methyl-3-hydroxybutyric acid level?",
    "seeds": [
      "Elevated urinary 2-methyl-3-hydroxybutyric acid level"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02069",
    "question": "What is associated with Unilateral brachydactyly?",
    "seeds": [
      "Unilateral brachydactyly"
    ],
    "gold_answer": "Short digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02070",
    "question": "What is associated with Cold-induced muscle cramps?",
    "seeds": [
      "Cold-induced muscle cramps"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02071",
    "question": "What is associated with Salpingitis?",
    "seeds": [
      "Salpingitis"
    ],
    "gold_answer": "Abnormal fallopian tube morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02072",
    "question": "What is associated with Sclerotic forearm bones?",
    "seeds": [
      "Sclerotic forearm bones"
    ],
    "gold_answer": "Abnormal forearm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02073",
    "question": "What is associated with Hypoplastic right atrium?",
    "seeds": [
      "Hypoplastic right atrium"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02074",
    "question": "What is associated with Hepatic sinusoidal dilatation?",
    "seeds": [
      "Hepatic sinusoidal dilatation"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02075",
    "question": "What is associated with Abnormality of the xiphoid process?",
    "seeds": [
      "Abnormality of the xiphoid process"
    ],
    "gold_answer": "Abnormal sternum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02076",
    "question": "What phenotype is associated with Vitamin B12-unresponsive methylmalonic acidemia type mut0?",
    "seeds": [
      "Vitamin B12-unresponsive methylmalonic acidemia type mut0"
    ],
    "gold_answer": "Dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02077",
    "question": "What phenotype is associated with Febrile seizures, familial, 2?",
    "seeds": [
      "Febrile seizures, familial, 2"
    ],
    "gold_answer": "Atonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02078",
    "question": "What is associated with Developmental delay-language impairment-dopa responsive dystonia-parkinsonism syndrome due to a NR4A2 point mutation?",
    "seeds": [
      "Developmental delay-language impairment-dopa responsive dystonia-parkinsonism syndrome due to a NR4A2 point mutation"
    ],
    "gold_answer": "NR4A2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02079",
    "question": "What is associated with Bracket epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Bracket epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02080",
    "question": "What is associated with Non-acquired panhypopituitarism?",
    "seeds": [
      "Non-acquired panhypopituitarism"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02081",
    "question": "What phenotype is associated with Epilepsy, progressive myoclonic, 9?",
    "seeds": [
      "Epilepsy, progressive myoclonic, 9"
    ],
    "gold_answer": "Ventriculomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02082",
    "question": "What phenotype is associated with Corneal dystrophy-perceptive deafness syndrome?",
    "seeds": [
      "Corneal dystrophy-perceptive deafness syndrome"
    ],
    "gold_answer": "Corneal opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02083",
    "question": "What is associated with Anomic aphasia?",
    "seeds": [
      "Anomic aphasia"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02084",
    "question": "What is associated with Cold-induced sweating?",
    "seeds": [
      "Cold-induced sweating"
    ],
    "gold_answer": "Abnormality of skin adnexa physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02085",
    "question": "What is associated with Increased urinary renal tubular epithelial cell count?",
    "seeds": [
      "Increased urinary renal tubular epithelial cell count"
    ],
    "gold_answer": "Increased urinary epithelial cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02086",
    "question": "What is associated with X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome?",
    "seeds": [
      "X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome"
    ],
    "gold_answer": "Abnormal upper lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02087",
    "question": "What is associated with Spondylometaphyseal dysplasia, X-linked?",
    "seeds": [
      "Spondylometaphyseal dysplasia, X-linked"
    ],
    "gold_answer": "Abnormal knee morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02088",
    "question": "What is associated with Spatulate ribs?",
    "seeds": [
      "Spatulate ribs"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02089",
    "question": "What is associated with Hypertrophic cardiomyopathy?",
    "seeds": [
      "Hypertrophic cardiomyopathy"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02090",
    "question": "What phenotype is associated with Encephalopathy due to defective mitochondrial and peroxisomal fission 2?",
    "seeds": [
      "Encephalopathy due to defective mitochondrial and peroxisomal fission 2"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02091",
    "question": "What is associated with Irregular epiphysis of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Irregular epiphysis of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Irregular epiphyses of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02092",
    "question": "What is associated with Hypoplastic iliac wing?",
    "seeds": [
      "Hypoplastic iliac wing"
    ],
    "gold_answer": "Abnormal hip bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02093",
    "question": "What phenotype is associated with Deafness, autosomal recessive 30?",
    "seeds": [
      "Deafness, autosomal recessive 30"
    ],
    "gold_answer": "Progressive hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02094",
    "question": "What is associated with Anti-transglutaminase 6 antibody?",
    "seeds": [
      "Anti-transglutaminase 6 antibody"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02095",
    "question": "What is associated with Trapezoidal distal femoral condyles?",
    "seeds": [
      "Trapezoidal distal femoral condyles"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02096",
    "question": "What is associated with Proportionate tall stature?",
    "seeds": [
      "Proportionate tall stature"
    ],
    "gold_answer": "Tall stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02097",
    "question": "What phenotype is associated with Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction?",
    "seeds": [
      "Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02098",
    "question": "What is associated with Nestor-Guillermo progeria syndrome?",
    "seeds": [
      "Nestor-Guillermo progeria syndrome"
    ],
    "gold_answer": "Abnormal atrioventricular valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02099",
    "question": "What phenotype is associated with Proteus-like syndrome?",
    "seeds": [
      "Proteus-like syndrome"
    ],
    "gold_answer": "Abnormal pupil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02100",
    "question": "What is associated with X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome?",
    "seeds": [
      "X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02101",
    "question": "What is associated with Hemoglobin D disease?",
    "seeds": [
      "Hemoglobin D disease"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02102",
    "question": "What is associated with Abnormal QRS voltage?",
    "seeds": [
      "Abnormal QRS voltage"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02103",
    "question": "What is associated with Vertical nystagmus?",
    "seeds": [
      "Vertical nystagmus"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02104",
    "question": "What is associated with MOGS-CDG?",
    "seeds": [
      "MOGS-CDG"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02105",
    "question": "What is associated with Hypogranulosis?",
    "seeds": [
      "Hypogranulosis"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02106",
    "question": "What phenotype is associated with Polyposis, skin pigmentation, alopecia, and fingernail changes?",
    "seeds": [
      "Polyposis, skin pigmentation, alopecia, and fingernail changes"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02107",
    "question": "What is associated with Subglottic stenosis?",
    "seeds": [
      "Subglottic stenosis"
    ],
    "gold_answer": "Abnormality of the larynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02108",
    "question": "What is associated with Citrullinemia type II?",
    "seeds": [
      "Citrullinemia type II"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02109",
    "question": "What is associated with Familial cylindromatosis?",
    "seeds": [
      "Familial cylindromatosis"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02110",
    "question": "What is associated with Cutis marmorata telangiectatica congenita?",
    "seeds": [
      "Cutis marmorata telangiectatica congenita"
    ],
    "gold_answer": "Nevus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02111",
    "question": "What is associated with Hyaloid vascular remnant and retrolental mass?",
    "seeds": [
      "Hyaloid vascular remnant and retrolental mass"
    ],
    "gold_answer": "Remnants of the hyaloid vascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02112",
    "question": "What is associated with Congenital alveolar dysplasia?",
    "seeds": [
      "Congenital alveolar dysplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the lungs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02113",
    "question": "What phenotype is associated with Acromesomelic dysplasia 4?",
    "seeds": [
      "Acromesomelic dysplasia 4"
    ],
    "gold_answer": "Sandal gap",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02114",
    "question": "What is associated with Abnormal ossification of the trapezoid bone?",
    "seeds": [
      "Abnormal ossification of the trapezoid bone"
    ],
    "gold_answer": "Abnormality of carpal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02115",
    "question": "What is associated with Hypoplastic umbilicus?",
    "seeds": [
      "Hypoplastic umbilicus"
    ],
    "gold_answer": "Abnormal umbilicus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02116",
    "question": "What is associated with Elevated circulating pristanic acid concentration following branched-chain fatty acid ingestion?",
    "seeds": [
      "Elevated circulating pristanic acid concentration following branched-chain fatty acid ingestion"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02117",
    "question": "What is associated with Submucous cleft lip?",
    "seeds": [
      "Submucous cleft lip"
    ],
    "gold_answer": "Cleft lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02118",
    "question": "What is associated with Decreased cervical spine flexion due to contractures of posterior cervical muscles?",
    "seeds": [
      "Decreased cervical spine flexion due to contractures of posterior cervical muscles"
    ],
    "gold_answer": "Joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02119",
    "question": "What is associated with Hazardous alcohol use?",
    "seeds": [
      "Hazardous alcohol use"
    ],
    "gold_answer": "Abnormal alcohol consumption",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02120",
    "question": "What is associated with Methemoglobinemia, Beta type?",
    "seeds": [
      "Methemoglobinemia, Beta type"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02121",
    "question": "What is associated with Cranioectodermal dysplasia 5?",
    "seeds": [
      "Cranioectodermal dysplasia 5"
    ],
    "gold_answer": "Disproportionate short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02122",
    "question": "What phenotype is associated with 5-@oxoprolinase deficiency?",
    "seeds": [
      "5-@oxoprolinase deficiency"
    ],
    "gold_answer": "Enterocolitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02123",
    "question": "What phenotype is associated with Spastic paraplegia 46, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 46, autosomal recessive"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02124",
    "question": "What is associated with Chronic?",
    "seeds": [
      "Chronic"
    ],
    "gold_answer": "Temporal pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02125",
    "question": "What is associated with Thyroid atypical adenoma?",
    "seeds": [
      "Thyroid atypical adenoma"
    ],
    "gold_answer": "Thyroid adenoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02126",
    "question": "What is associated with Enlarged thorax?",
    "seeds": [
      "Enlarged thorax"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02127",
    "question": "What is associated with Boomerang dysplasia?",
    "seeds": [
      "Boomerang dysplasia"
    ],
    "gold_answer": "Disproportionate short-limb short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02128",
    "question": "What is associated with KID syndrome?",
    "seeds": [
      "KID syndrome"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02129",
    "question": "What phenotype is associated with Spastic paraplegia 23?",
    "seeds": [
      "Spastic paraplegia 23"
    ],
    "gold_answer": "Micrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02130",
    "question": "What phenotype is associated with Myopathy, myofibrillar, 2, mfm2?",
    "seeds": [
      "Myopathy, myofibrillar, 2, mfm2"
    ],
    "gold_answer": "Antinuclear antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02131",
    "question": "What is associated with Hot cross bun sign?",
    "seeds": [
      "Hot cross bun sign"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02132",
    "question": "What is associated with Limited elbow flexion?",
    "seeds": [
      "Limited elbow flexion"
    ],
    "gold_answer": "Abnormality of the elbow",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02133",
    "question": "What is associated with GALACTORRHEA?",
    "seeds": [
      "GALACTORRHEA"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02134",
    "question": "What phenotype is associated with Orofaciodigital syndrome type 5?",
    "seeds": [
      "Orofaciodigital syndrome type 5"
    ],
    "gold_answer": "Postaxial foot polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02135",
    "question": "What is associated with Autosomal dominant inheritance with maternal imprinting?",
    "seeds": [
      "Autosomal dominant inheritance with maternal imprinting"
    ],
    "gold_answer": "Mode of inheritance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02136",
    "question": "What is associated with Radiating pain?",
    "seeds": [
      "Radiating pain"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02137",
    "question": "What phenotype is associated with DERMATOGLYPHICS--FINGERPRINT PATTERN?",
    "seeds": [
      "DERMATOGLYPHICS--FINGERPRINT PATTERN"
    ],
    "gold_answer": "Abnormal dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02138",
    "question": "What is associated with Absent epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Absent epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the proximal phalanx of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02139",
    "question": "What is associated with Hair-pulling?",
    "seeds": [
      "Hair-pulling"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02140",
    "question": "What phenotype is associated with C syndrome?",
    "seeds": [
      "C syndrome"
    ],
    "gold_answer": "Micrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02141",
    "question": "What is associated with Neoplasm of the tracheobronchial system?",
    "seeds": [
      "Neoplasm of the tracheobronchial system"
    ],
    "gold_answer": "Neoplasm of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02142",
    "question": "What is associated with Charcot-Marie-Tooth disease, demyelinating, type 1G?",
    "seeds": [
      "Charcot-Marie-Tooth disease, demyelinating, type 1G"
    ],
    "gold_answer": "Abnormal pyramidal sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02143",
    "question": "What is associated with Deep cerebral white matter hyperintensities?",
    "seeds": [
      "Deep cerebral white matter hyperintensities"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02144",
    "question": "What is associated with Brachydactyly-arterial hypertension syndrome?",
    "seeds": [
      "Brachydactyly-arterial hypertension syndrome"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02145",
    "question": "What is associated with Cystic hamartoma of lung and kidney?",
    "seeds": [
      "Cystic hamartoma of lung and kidney"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02146",
    "question": "What is associated with Small intestine carcinoid?",
    "seeds": [
      "Small intestine carcinoid"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02147",
    "question": "What is associated with Exacerbated by amiodarone exposure?",
    "seeds": [
      "Exacerbated by amiodarone exposure"
    ],
    "gold_answer": "Aggravated by exposure to medication",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02148",
    "question": "What is associated with Abnormal circulating reverse T3 concentration?",
    "seeds": [
      "Abnormal circulating reverse T3 concentration"
    ],
    "gold_answer": "Abnormal circulating thyroid hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02149",
    "question": "What is associated with Unilateral renal atrophy?",
    "seeds": [
      "Unilateral renal atrophy"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02150",
    "question": "What is associated with Abnormal soft palate morphology?",
    "seeds": [
      "Abnormal soft palate morphology"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02151",
    "question": "What phenotype is associated with Ichthyosis, congenital, autosomal recessive 4B?",
    "seeds": [
      "Ichthyosis, congenital, autosomal recessive 4B"
    ],
    "gold_answer": "Congenital ichthyosiform erythroderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02152",
    "question": "What is associated with Hypoplastic female external genitalia?",
    "seeds": [
      "Hypoplastic female external genitalia"
    ],
    "gold_answer": "Abnormality of the female genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02153",
    "question": "What is associated with Groin pain?",
    "seeds": [
      "Groin pain"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02154",
    "question": "What is associated with Autoamputation?",
    "seeds": [
      "Autoamputation"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02155",
    "question": "What is associated with Axonal regeneration?",
    "seeds": [
      "Axonal regeneration"
    ],
    "gold_answer": "Peripheral axonal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02156",
    "question": "What is associated with Sensory hypersensitivity?",
    "seeds": [
      "Sensory hypersensitivity"
    ],
    "gold_answer": "Sensory behavioral abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02157",
    "question": "What is associated with Agenesis of mandibular lateral incisor?",
    "seeds": [
      "Agenesis of mandibular lateral incisor"
    ],
    "gold_answer": "Agenesis of incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02158",
    "question": "What is associated with Focal aware motor seizure with version?",
    "seeds": [
      "Focal aware motor seizure with version"
    ],
    "gold_answer": "Focal aware seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02159",
    "question": "What is associated with Abnormal ventricular filling?",
    "seeds": [
      "Abnormal ventricular filling"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02160",
    "question": "What is associated with Abnormal auditory canal morphology?",
    "seeds": [
      "Abnormal auditory canal morphology"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02161",
    "question": "What is associated with Increased CSF phenylalanine concentration?",
    "seeds": [
      "Increased CSF phenylalanine concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02162",
    "question": "What is associated with Advanced pneumatization of the mastoid process?",
    "seeds": [
      "Advanced pneumatization of the mastoid process"
    ],
    "gold_answer": "Abnormal mastoid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02163",
    "question": "What is associated with Multifocal motor neuropathy?",
    "seeds": [
      "Multifocal motor neuropathy"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02164",
    "question": "What is associated with Absent nasal bridge?",
    "seeds": [
      "Absent nasal bridge"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02165",
    "question": "What is associated with Broad foot?",
    "seeds": [
      "Broad foot"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02166",
    "question": "What is associated with Exercise-induced leg cramps?",
    "seeds": [
      "Exercise-induced leg cramps"
    ],
    "gold_answer": "Muscle spasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02167",
    "question": "What is associated with Elevated circulating acetylcarnitine concentration?",
    "seeds": [
      "Elevated circulating acetylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02168",
    "question": "What is associated with Absent patellar reflexes?",
    "seeds": [
      "Absent patellar reflexes"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02169",
    "question": "What is associated with Amegakaryocytic thrombocytopenia, congenital, 2?",
    "seeds": [
      "Amegakaryocytic thrombocytopenia, congenital, 2"
    ],
    "gold_answer": "Abnormality of multiple cell lineages in the bone marrow",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02170",
    "question": "What is associated with Extrahepatic biliary duct atresia?",
    "seeds": [
      "Extrahepatic biliary duct atresia"
    ],
    "gold_answer": "Abnormal biliary tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02171",
    "question": "What is associated with Agenesis of putamen?",
    "seeds": [
      "Agenesis of putamen"
    ],
    "gold_answer": "Abnormal corpus striatum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02172",
    "question": "What is associated with Late-infantile/juvenile Krabbe disease?",
    "seeds": [
      "Late-infantile/juvenile Krabbe disease"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02173",
    "question": "What is associated with Epilepsy, idiopathic generalized?",
    "seeds": [
      "Epilepsy, idiopathic generalized"
    ],
    "gold_answer": "EEG with spike-wave complexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02174",
    "question": "What is associated with ACys amyloidosis?",
    "seeds": [
      "ACys amyloidosis"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02175",
    "question": "What is associated with Focal impaired awareness cognitive seizure with illusion?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with illusion"
    ],
    "gold_answer": "Focal cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02176",
    "question": "What is associated with Prenatal death?",
    "seeds": [
      "Prenatal death"
    ],
    "gold_answer": "Clinical course",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02177",
    "question": "What is associated with Joubert syndrome with renal defect?",
    "seeds": [
      "Joubert syndrome with renal defect"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02178",
    "question": "What is associated with Abnormal anatomic location of the heart?",
    "seeds": [
      "Abnormal anatomic location of the heart"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02179",
    "question": "What is associated with Nevus comedonicus?",
    "seeds": [
      "Nevus comedonicus"
    ],
    "gold_answer": "Epidermal nevus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02180",
    "question": "What is associated with Distichiasis?",
    "seeds": [
      "Distichiasis"
    ],
    "gold_answer": "Abnormal eyelash morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02181",
    "question": "What is associated with Athyreosis?",
    "seeds": [
      "Athyreosis"
    ],
    "gold_answer": "Hernia of the abdominal wall",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02182",
    "question": "What is associated with Exercise-induced muscle cramps?",
    "seeds": [
      "Exercise-induced muscle cramps"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02183",
    "question": "What is associated with Aorto-left ventricular tunnel?",
    "seeds": [
      "Aorto-left ventricular tunnel"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02184",
    "question": "What phenotype is associated with Congenital pseudoarthrosis of the clavicle?",
    "seeds": [
      "Congenital pseudoarthrosis of the clavicle"
    ],
    "gold_answer": "Abnormal lung lobation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02185",
    "question": "What is associated with Focal cognitive seizure with conduction dysphasia/aphasia?",
    "seeds": [
      "Focal cognitive seizure with conduction dysphasia/aphasia"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02186",
    "question": "What is associated with 15q11.2 microdeletion syndrome?",
    "seeds": [
      "15q11.2 microdeletion syndrome"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02187",
    "question": "What is associated with SCHISTOSOMA MANSONI INFECTION, SUSCEPTIBILITY/RESISTANCE TO?",
    "seeds": [
      "SCHISTOSOMA MANSONI INFECTION, SUSCEPTIBILITY/RESISTANCE TO"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02188",
    "question": "What is associated with Progeroid features-hepatocellular carcinoma predisposition syndrome?",
    "seeds": [
      "Progeroid features-hepatocellular carcinoma predisposition syndrome"
    ],
    "gold_answer": "SPRTN",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_test_02189",
    "question": "What is associated with Restrictive ventilatory defect?",
    "seeds": [
      "Restrictive ventilatory defect"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02190",
    "question": "What is associated with Thumb hypoplasia grade 3B?",
    "seeds": [
      "Thumb hypoplasia grade 3B"
    ],
    "gold_answer": "Short digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02191",
    "question": "What is associated with Pulmonary parenchymal band?",
    "seeds": [
      "Pulmonary parenchymal band"
    ],
    "gold_answer": "Pulmonary opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02192",
    "question": "What phenotype is associated with Spondyloepimetaphyseal dysplasia, sponastrime type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, sponastrime type"
    ],
    "gold_answer": "Lumbar hyperlordosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02193",
    "question": "What is associated with Abnormality of depressor anguli oris muscle?",
    "seeds": [
      "Abnormality of depressor anguli oris muscle"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02194",
    "question": "What is associated with Increased anti-seafood IgE antibody level?",
    "seeds": [
      "Increased anti-seafood IgE antibody level"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02195",
    "question": "What is associated with Birth length greater than 97th percentile?",
    "seeds": [
      "Birth length greater than 97th percentile"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02196",
    "question": "What is associated with Chitayat syndrome?",
    "seeds": [
      "Chitayat syndrome"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02197",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 72?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 72"
    ],
    "gold_answer": "Dolichocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02198",
    "question": "What is associated with Mycobacterial and viral infections, susceptibility to, autosomal recessive?",
    "seeds": [
      "Mycobacterial and viral infections, susceptibility to, autosomal recessive"
    ],
    "gold_answer": "Recurrent bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02199",
    "question": "What is associated with Inflammatory skin and bowel disease, neonatal, 1?",
    "seeds": [
      "Inflammatory skin and bowel disease, neonatal, 1"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02200",
    "question": "What is associated with Dilated cardiomyopathy?",
    "seeds": [
      "Dilated cardiomyopathy"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02201",
    "question": "What phenotype is associated with Aniridia and absent patella?",
    "seeds": [
      "Aniridia and absent patella"
    ],
    "gold_answer": "Exotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02202",
    "question": "What is associated with Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02203",
    "question": "What is associated with Absent epiphyses of the proximal phalanges of the hand?",
    "seeds": [
      "Absent epiphyses of the proximal phalanges of the hand"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02204",
    "question": "What is associated with Cutaneous angiolipomas?",
    "seeds": [
      "Cutaneous angiolipomas"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02205",
    "question": "What is associated with Parachute mitral valve?",
    "seeds": [
      "Parachute mitral valve"
    ],
    "gold_answer": "Abnormal atrioventricular valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02206",
    "question": "What is associated with Irregular epiphyses of the elbow?",
    "seeds": [
      "Irregular epiphyses of the elbow"
    ],
    "gold_answer": "Irregular epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02207",
    "question": "What is associated with Microphthalmia, isolated 1?",
    "seeds": [
      "Microphthalmia, isolated 1"
    ],
    "gold_answer": "Aplasia/Hypoplasia affecting the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02208",
    "question": "What is associated with IRIDA syndrome?",
    "seeds": [
      "IRIDA syndrome"
    ],
    "gold_answer": "Abnormal mean corpuscular volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02209",
    "question": "What is associated with Decreased dermal collagen?",
    "seeds": [
      "Decreased dermal collagen"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02210",
    "question": "What is associated with Increased nuchal translucency?",
    "seeds": [
      "Increased nuchal translucency"
    ],
    "gold_answer": "Abnormal neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02211",
    "question": "What is associated with Basal ganglia calcification, idiopathic, 5?",
    "seeds": [
      "Basal ganglia calcification, idiopathic, 5"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02212",
    "question": "What phenotype is associated with Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome?",
    "seeds": [
      "Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome"
    ],
    "gold_answer": "Infectious encephalitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02213",
    "question": "What is associated with Palpebral edema?",
    "seeds": [
      "Palpebral edema"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02214",
    "question": "What phenotype is associated with Fixed subaortic stenosis?",
    "seeds": [
      "Fixed subaortic stenosis"
    ],
    "gold_answer": "Coarctation of the descending aortic arch",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02215",
    "question": "What is associated with Curved middle phalanges of the hand?",
    "seeds": [
      "Curved middle phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02216",
    "question": "What is associated with Sensorineural deafness with dilated cardiomyopathy?",
    "seeds": [
      "Sensorineural deafness with dilated cardiomyopathy"
    ],
    "gold_answer": "Abnormal middle ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02217",
    "question": "What is associated with Abnormal nail growth?",
    "seeds": [
      "Abnormal nail growth"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02218",
    "question": "What is associated with X-linked severe congenital neutropenia?",
    "seeds": [
      "X-linked severe congenital neutropenia"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02219",
    "question": "What is associated with Pleural rub?",
    "seeds": [
      "Pleural rub"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02220",
    "question": "What phenotype is associated with Urticaria, aquagenic?",
    "seeds": [
      "Urticaria, aquagenic"
    ],
    "gold_answer": "Urticaria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02221",
    "question": "What is associated with Temporal hypotrichosis?",
    "seeds": [
      "Temporal hypotrichosis"
    ],
    "gold_answer": "Congenital abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02222",
    "question": "What is associated with Curved phalanges of the 5th finger?",
    "seeds": [
      "Curved phalanges of the 5th finger"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02223",
    "question": "What is associated with Absent epiphyses of the 5th toe?",
    "seeds": [
      "Absent epiphyses of the 5th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02224",
    "question": "What is associated with Hyperautofluorescent retinal lesion?",
    "seeds": [
      "Hyperautofluorescent retinal lesion"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02225",
    "question": "What phenotype is associated with Tetralogy of Fallot and glaucoma?",
    "seeds": [
      "Tetralogy of Fallot and glaucoma"
    ],
    "gold_answer": "Broad forehead",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02226",
    "question": "What is associated with Danubian endemic familial nephropathy?",
    "seeds": [
      "Danubian endemic familial nephropathy"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02227",
    "question": "What is associated with Increased circulating osteocalcin level?",
    "seeds": [
      "Increased circulating osteocalcin level"
    ],
    "gold_answer": "Abnormal circulating osteocalcin level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02228",
    "question": "What is associated with Agenesis of premolar?",
    "seeds": [
      "Agenesis of premolar"
    ],
    "gold_answer": "Abnormality of premolar",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02229",
    "question": "What is associated with Dexamethasone-suppressible primary hyperaldosteronism?",
    "seeds": [
      "Dexamethasone-suppressible primary hyperaldosteronism"
    ],
    "gold_answer": "Increased circulating aldosterone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02230",
    "question": "What phenotype is associated with Meier-Gorlin syndrome 3?",
    "seeds": [
      "Meier-Gorlin syndrome 3"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02231",
    "question": "What is associated with Partial absence of specific antibody response to meningococcus vaccine?",
    "seeds": [
      "Partial absence of specific antibody response to meningococcus vaccine"
    ],
    "gold_answer": "Decreased circulating level of specific antibody",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02232",
    "question": "What is associated with Fusiform ascending tubular aorta aneurysm?",
    "seeds": [
      "Fusiform ascending tubular aorta aneurysm"
    ],
    "gold_answer": "Ascending tubular aorta aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02233",
    "question": "What phenotype is associated with DUODENAL ULCER DUE TO ANTRAL G-CELL HYPERFUNCTION?",
    "seeds": [
      "DUODENAL ULCER DUE TO ANTRAL G-CELL HYPERFUNCTION"
    ],
    "gold_answer": "Duodenal ulcer",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02234",
    "question": "What phenotype is associated with Pyruvate carboxylase deficiency?",
    "seeds": [
      "Pyruvate carboxylase deficiency"
    ],
    "gold_answer": "Hypovolemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02235",
    "question": "What is associated with Prominent crus of helix?",
    "seeds": [
      "Prominent crus of helix"
    ],
    "gold_answer": "Abnormal helix morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02236",
    "question": "What is associated with Thyroid defect in oxidation and organification of iodide?",
    "seeds": [
      "Thyroid defect in oxidation and organification of iodide"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02237",
    "question": "What is associated with Tremor, hereditary essential, 5?",
    "seeds": [
      "Tremor, hereditary essential, 5"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02238",
    "question": "What is associated with Epiphyseal deformities of tubular bones?",
    "seeds": [
      "Epiphyseal deformities of tubular bones"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02239",
    "question": "What is associated with Labial pseudohypertrophy?",
    "seeds": [
      "Labial pseudohypertrophy"
    ],
    "gold_answer": "Abnormal labia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02240",
    "question": "What phenotype is associated with Uric acid concentration, serum, QTL1?",
    "seeds": [
      "Uric acid concentration, serum, QTL1"
    ],
    "gold_answer": "Arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02241",
    "question": "What is associated with Dysharmonic accelerated bone age?",
    "seeds": [
      "Dysharmonic accelerated bone age"
    ],
    "gold_answer": "Dysharmonic skeletal maturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02242",
    "question": "What is associated with Perianal abscess?",
    "seeds": [
      "Perianal abscess"
    ],
    "gold_answer": "Abscess",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02243",
    "question": "What is associated with 2-oxoadipic aciduria?",
    "seeds": [
      "2-oxoadipic aciduria"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02244",
    "question": "What is associated with Abnormal cerumen color?",
    "seeds": [
      "Abnormal cerumen color"
    ],
    "gold_answer": "Cerumen abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02245",
    "question": "What phenotype is associated with Distal myopathy, Tateyama type?",
    "seeds": [
      "Distal myopathy, Tateyama type"
    ],
    "gold_answer": "Myalgia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02246",
    "question": "What is associated with Sputum eosinophilia?",
    "seeds": [
      "Sputum eosinophilia"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02247",
    "question": "What is associated with Increased core 1 O-glycan level?",
    "seeds": [
      "Increased core 1 O-glycan level"
    ],
    "gold_answer": "Abnormal protein O-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02248",
    "question": "What is associated with Triangular shaped distal phalanx of the 2nd toe?",
    "seeds": [
      "Triangular shaped distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02249",
    "question": "What is associated with Long QT syndrome 2?",
    "seeds": [
      "Long QT syndrome 2"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02250",
    "question": "What is associated with Cleft maxillary alveolar ridge?",
    "seeds": [
      "Cleft maxillary alveolar ridge"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02251",
    "question": "What is associated with Accessory scrotum?",
    "seeds": [
      "Accessory scrotum"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02252",
    "question": "What is associated with Unilateral wrist flexion contracture?",
    "seeds": [
      "Unilateral wrist flexion contracture"
    ],
    "gold_answer": "Upper-limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02253",
    "question": "What is associated with Polyostotic fibrous dysplasia?",
    "seeds": [
      "Polyostotic fibrous dysplasia"
    ],
    "gold_answer": "GNAS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02254",
    "question": "What is associated with Atrophodermia vermiculata?",
    "seeds": [
      "Atrophodermia vermiculata"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02255",
    "question": "What is associated with Aplasia of the uterus?",
    "seeds": [
      "Aplasia of the uterus"
    ],
    "gold_answer": "Abnormality of the uterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02256",
    "question": "What phenotype is associated with Deafness, autosomal dominant 88?",
    "seeds": [
      "Deafness, autosomal dominant 88"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02257",
    "question": "What is associated with Germinoma?",
    "seeds": [
      "Germinoma"
    ],
    "gold_answer": "Germ cell neoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02258",
    "question": "What is associated with Abnormal brain FDG positron emission tomography?",
    "seeds": [
      "Abnormal brain FDG positron emission tomography"
    ],
    "gold_answer": "Abnormal brain positron emission tomography",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02259",
    "question": "What is associated with Pseudoepiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Pseudoepiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Pseudoepiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02260",
    "question": "What is associated with Marginal corneal dystrophy?",
    "seeds": [
      "Marginal corneal dystrophy"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02261",
    "question": "What is associated with Cone-shaped epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Cone-shaped epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the proximal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02262",
    "question": "What is associated with Small toe?",
    "seeds": [
      "Small toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02263",
    "question": "What is associated with Gait imbalance?",
    "seeds": [
      "Gait imbalance"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02264",
    "question": "What is associated with Thyroid cancer, nonmedullary, 1?",
    "seeds": [
      "Thyroid cancer, nonmedullary, 1"
    ],
    "gold_answer": "Abnormal thyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02265",
    "question": "What is associated with Abnormal scapula morphology?",
    "seeds": [
      "Abnormal scapula morphology"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02266",
    "question": "What is associated with Oliver-McFarlane syndrome?",
    "seeds": [
      "Oliver-McFarlane syndrome"
    ],
    "gold_answer": "Paraplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02267",
    "question": "What is associated with Small superior frontal cortex?",
    "seeds": [
      "Small superior frontal cortex"
    ],
    "gold_answer": "Small cerebral cortex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02268",
    "question": "What phenotype is associated with Lip, hamartomatous?",
    "seeds": [
      "Lip, hamartomatous"
    ],
    "gold_answer": "Hamartoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02269",
    "question": "What is associated with Hydralazine exposure?",
    "seeds": [
      "Hydralazine exposure"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02270",
    "question": "What is associated with Pleural lymphangiectasia?",
    "seeds": [
      "Pleural lymphangiectasia"
    ],
    "gold_answer": "Abnormal lymphatic vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02271",
    "question": "What is associated with Muscular dystrophy, congenital, with rapid progression?",
    "seeds": [
      "Muscular dystrophy, congenital, with rapid progression"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02272",
    "question": "What is associated with Abnormal mouth floor morphology?",
    "seeds": [
      "Abnormal mouth floor morphology"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02273",
    "question": "What is associated with Dystonia 25?",
    "seeds": [
      "Dystonia 25"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02274",
    "question": "What is associated with Pachygyria?",
    "seeds": [
      "Pachygyria"
    ],
    "gold_answer": "Abnormal cortical gyration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02275",
    "question": "What is associated with History of recent participation in athletics?",
    "seeds": [
      "History of recent participation in athletics"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02276",
    "question": "What is associated with Immediate Echolalia?",
    "seeds": [
      "Immediate Echolalia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02277",
    "question": "What is associated with Congenital earlobe sinuses?",
    "seeds": [
      "Congenital earlobe sinuses"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02278",
    "question": "What is associated with Recurrent genital herpes?",
    "seeds": [
      "Recurrent genital herpes"
    ],
    "gold_answer": "Recurrent herpes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02279",
    "question": "What is associated with Anasarca?",
    "seeds": [
      "Anasarca"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02280",
    "question": "What is associated with Intestinal hemangioma?",
    "seeds": [
      "Intestinal hemangioma"
    ],
    "gold_answer": "Hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02281",
    "question": "What is associated with Neuronopathy, distal hereditary motor, autosomal recessive 10?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, autosomal recessive 10"
    ],
    "gold_answer": "Abnormal peripheral myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02282",
    "question": "What is associated with Cytokine storm?",
    "seeds": [
      "Cytokine storm"
    ],
    "gold_answer": "Abnormal immune serum protein physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02283",
    "question": "What phenotype is associated with Autosomal recessive ataxia due to ubiquinone deficiency?",
    "seeds": [
      "Autosomal recessive ataxia due to ubiquinone deficiency"
    ],
    "gold_answer": "Developmental regression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02284",
    "question": "What is associated with Myopathy, congenital, with fiber-type disproportion, X-linked?",
    "seeds": [
      "Myopathy, congenital, with fiber-type disproportion, X-linked"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02285",
    "question": "What is associated with Enlarged metacarpophalangeal joints?",
    "seeds": [
      "Enlarged metacarpophalangeal joints"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02286",
    "question": "What is associated with Urinary urgency?",
    "seeds": [
      "Urinary urgency"
    ],
    "gold_answer": "Abnormality of the lower urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02287",
    "question": "What is associated with Freeman-Sheldon syndrome?",
    "seeds": [
      "Freeman-Sheldon syndrome"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02288",
    "question": "What is associated with Painful defecation?",
    "seeds": [
      "Painful defecation"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02289",
    "question": "What is associated with Chondrodysplasia punctata 1, X-linked recessive?",
    "seeds": [
      "Chondrodysplasia punctata 1, X-linked recessive"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02290",
    "question": "What is associated with Pancreatic intraductal papillary mucinous neoplasm?",
    "seeds": [
      "Pancreatic intraductal papillary mucinous neoplasm"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02291",
    "question": "What is associated with Megaloblepharon?",
    "seeds": [
      "Megaloblepharon"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02292",
    "question": "What is associated with Brachioradialis hyporeflexia?",
    "seeds": [
      "Brachioradialis hyporeflexia"
    ],
    "gold_answer": "Hyporeflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02293",
    "question": "What is associated with Spondylometaphyseal dysplasia, corner Fracture type?",
    "seeds": [
      "Spondylometaphyseal dysplasia, corner Fracture type"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02294",
    "question": "What phenotype is associated with Premature ovarian failure 2B?",
    "seeds": [
      "Premature ovarian failure 2B"
    ],
    "gold_answer": "Premature ovarian insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02295",
    "question": "What is associated with Subretinal exudate?",
    "seeds": [
      "Subretinal exudate"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02296",
    "question": "What is associated with Complete duplication of distal phalanx of the thumb?",
    "seeds": [
      "Complete duplication of distal phalanx of the thumb"
    ],
    "gold_answer": "Duplication of thumb phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02297",
    "question": "What is associated with Encephalopathy, acute, infection-induced, susceptibility to, 4?",
    "seeds": [
      "Encephalopathy, acute, infection-induced, susceptibility to, 4"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02298",
    "question": "What is associated with Noonan syndrome 3?",
    "seeds": [
      "Noonan syndrome 3"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02299",
    "question": "What phenotype is associated with PCNA-related progressive neurodegenerative photosensitivity syndrome?",
    "seeds": [
      "PCNA-related progressive neurodegenerative photosensitivity syndrome"
    ],
    "gold_answer": "Hypoxemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02300",
    "question": "What is associated with Ameliorated by riboflavin?",
    "seeds": [
      "Ameliorated by riboflavin"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02301",
    "question": "What is associated with Axenfeld-Rieger anomaly with partially absent eye muscles, distinctive face, hydrocephaly, and skeletal abnormalities?",
    "seeds": [
      "Axenfeld-Rieger anomaly with partially absent eye muscles, distinctive face, hydrocephaly, and skeletal abnormalities"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02302",
    "question": "What is associated with Childhood-onset basal ganglia degeneration syndrome?",
    "seeds": [
      "Childhood-onset basal ganglia degeneration syndrome"
    ],
    "gold_answer": "VAC14",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02303",
    "question": "What is associated with Caudate atrophy?",
    "seeds": [
      "Caudate atrophy"
    ],
    "gold_answer": "Brain atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02304",
    "question": "What is associated with Atypical nevus?",
    "seeds": [
      "Atypical nevus"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02305",
    "question": "What is associated with Abnormal CSF arginine concentration?",
    "seeds": [
      "Abnormal CSF arginine concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02306",
    "question": "What is associated with Isolated growth hormone deficiency type IV?",
    "seeds": [
      "Isolated growth hormone deficiency type IV"
    ],
    "gold_answer": "GHRHR",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02307",
    "question": "What is associated with Purulent sputum?",
    "seeds": [
      "Purulent sputum"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02308",
    "question": "What phenotype is associated with Marden-Walker syndrome?",
    "seeds": [
      "Marden-Walker syndrome"
    ],
    "gold_answer": "Anteverted nares",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02309",
    "question": "What is associated with Myoclonic seizure?",
    "seeds": [
      "Myoclonic seizure"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02310",
    "question": "What is associated with Neurodevelopmental disorder with ataxia, hypotonia, and microcephaly?",
    "seeds": [
      "Neurodevelopmental disorder with ataxia, hypotonia, and microcephaly"
    ],
    "gold_answer": "Skin tags",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02311",
    "question": "What is associated with Hereditary motor and sensory neuropathy VIA?",
    "seeds": [
      "Hereditary motor and sensory neuropathy VIA"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02312",
    "question": "What is associated with Aplasia of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Aplasia of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Aplasia of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02313",
    "question": "What is associated with Tetanus?",
    "seeds": [
      "Tetanus"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02314",
    "question": "What phenotype is associated with Glycine encephalopathy?",
    "seeds": [
      "Glycine encephalopathy"
    ],
    "gold_answer": "Abnormal metabolic brain imaging by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02315",
    "question": "What phenotype is associated with Retinitis pigmentosa 26?",
    "seeds": [
      "Retinitis pigmentosa 26"
    ],
    "gold_answer": "Optic disc pallor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02316",
    "question": "What is associated with Delayed ossification of the sacrum?",
    "seeds": [
      "Delayed ossification of the sacrum"
    ],
    "gold_answer": "Abnormal sacrum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02317",
    "question": "What is associated with Abnormal circulating superoxide dismutase activity?",
    "seeds": [
      "Abnormal circulating superoxide dismutase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02318",
    "question": "What is associated with Myofibromatosis, infantile, 1?",
    "seeds": [
      "Myofibromatosis, infantile, 1"
    ],
    "gold_answer": "Sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02319",
    "question": "What is associated with Difficulty climbing stairs?",
    "seeds": [
      "Difficulty climbing stairs"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02320",
    "question": "What is associated with Brachydactyly, type A2, with microcephaly?",
    "seeds": [
      "Brachydactyly, type A2, with microcephaly"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02321",
    "question": "What is associated with Cholesteatoma?",
    "seeds": [
      "Cholesteatoma"
    ],
    "gold_answer": "Abnormal middle ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02322",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 62?",
    "seeds": [
      "Developmental and epileptic encephalopathy 62"
    ],
    "gold_answer": "Central nervous system degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02323",
    "question": "What phenotype is associated with Neuronopathy, distal hereditary motor, type X?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, type X"
    ],
    "gold_answer": "Small thenar eminence",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02324",
    "question": "What is associated with Positive blood infectious agent test?",
    "seeds": [
      "Positive blood infectious agent test"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02325",
    "question": "What phenotype is associated with Acne inversa, familial?",
    "seeds": [
      "Acne inversa, familial"
    ],
    "gold_answer": "Atypical scarring of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02326",
    "question": "What is associated with Myopathy?",
    "seeds": [
      "Myopathy"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02327",
    "question": "What is associated with Cataract, crystalline coralliform?",
    "seeds": [
      "Cataract, crystalline coralliform"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02328",
    "question": "What phenotype is associated with Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis?",
    "seeds": [
      "Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis"
    ],
    "gold_answer": "Knee dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02329",
    "question": "What is associated with Slender long bone?",
    "seeds": [
      "Slender long bone"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02330",
    "question": "What is associated with Exostoses, multiple, type III?",
    "seeds": [
      "Exostoses, multiple, type III"
    ],
    "gold_answer": "Exostoses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02331",
    "question": "What is associated with Globulin anomaly involving beta (2a)-globulin?",
    "seeds": [
      "Globulin anomaly involving beta (2a)-globulin"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02332",
    "question": "What is associated with Mesenteric cyst?",
    "seeds": [
      "Mesenteric cyst"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02333",
    "question": "What phenotype is associated with Retinitis pigmentosa 60?",
    "seeds": [
      "Retinitis pigmentosa 60"
    ],
    "gold_answer": "Posterior subcapsular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02334",
    "question": "What is associated with Increased anti-insect IgE antibody level?",
    "seeds": [
      "Increased anti-insect IgE antibody level"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02335",
    "question": "What is associated with Absent internal genitalia?",
    "seeds": [
      "Absent internal genitalia"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02336",
    "question": "What is associated with Kallmann syndrome-heart disease syndrome?",
    "seeds": [
      "Kallmann syndrome-heart disease syndrome"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02337",
    "question": "What is associated with Decreased circulating luteinizing hormone level?",
    "seeds": [
      "Decreased circulating luteinizing hormone level"
    ],
    "gold_answer": "Abnormal circulating gonadotropin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02338",
    "question": "What is associated with Renal amyloidosis?",
    "seeds": [
      "Renal amyloidosis"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02339",
    "question": "What is associated with Impacted cerumen?",
    "seeds": [
      "Impacted cerumen"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02340",
    "question": "What is associated with High urinary gonadotropin level?",
    "seeds": [
      "High urinary gonadotropin level"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02341",
    "question": "What is associated with Grade V vesicoureteral reflux?",
    "seeds": [
      "Grade V vesicoureteral reflux"
    ],
    "gold_answer": "Vesicoureteral reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02342",
    "question": "What is associated with Frontal upsweep of hair?",
    "seeds": [
      "Frontal upsweep of hair"
    ],
    "gold_answer": "Congenital abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02343",
    "question": "What is associated with Osteolysis involving bones of the lower limbs?",
    "seeds": [
      "Osteolysis involving bones of the lower limbs"
    ],
    "gold_answer": "Abnormal bone structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02344",
    "question": "What is associated with Increased hematocrit?",
    "seeds": [
      "Increased hematocrit"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02345",
    "question": "What phenotype is associated with Craniofacial dyssynostosis with short stature?",
    "seeds": [
      "Craniofacial dyssynostosis with short stature"
    ],
    "gold_answer": "Malar flattening",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02346",
    "question": "What is associated with Muscular dystrophy, limb-girdle, autosomal recessive 10?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, autosomal recessive 10"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02347",
    "question": "What is associated with Pulmonary oligemia?",
    "seeds": [
      "Pulmonary oligemia"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02348",
    "question": "What is associated with Salpingitis?",
    "seeds": [
      "Salpingitis"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02349",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 34?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 34"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02350",
    "question": "What phenotype is associated with Cerebellar atrophy, developmental delay, and seizures?",
    "seeds": [
      "Cerebellar atrophy, developmental delay, and seizures"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02351",
    "question": "What is associated with Abnormal meiosis?",
    "seeds": [
      "Abnormal meiosis"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02352",
    "question": "What is associated with Dystonic gait?",
    "seeds": [
      "Dystonic gait"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02353",
    "question": "What is associated with Fractured middle phalanx of manual digit 2?",
    "seeds": [
      "Fractured middle phalanx of manual digit 2"
    ],
    "gold_answer": "Abnormality of the phalanges of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02354",
    "question": "What is associated with Atoll sign?",
    "seeds": [
      "Atoll sign"
    ],
    "gold_answer": "Abnormal pulmonary thoracic imaging finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02355",
    "question": "What is associated with Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia?",
    "seeds": [
      "Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia"
    ],
    "gold_answer": "Impairment in personality functioning",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02356",
    "question": "What is associated with Slit-like opening of the exterior auditory meatus?",
    "seeds": [
      "Slit-like opening of the exterior auditory meatus"
    ],
    "gold_answer": "Stenosis of the external auditory canal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02357",
    "question": "What is associated with Hirschsprung disease, susceptibility to, 2?",
    "seeds": [
      "Hirschsprung disease, susceptibility to, 2"
    ],
    "gold_answer": "Abnormal enteric nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02358",
    "question": "What is associated with Duplication of the phalanges of the 2nd toe?",
    "seeds": [
      "Duplication of the phalanges of the 2nd toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02359",
    "question": "What is associated with Broad proximal phalanx of the 5th toe?",
    "seeds": [
      "Broad proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Broad proximal phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02360",
    "question": "What is associated with Severe intellectual disability and progressive spastic paraplegia?",
    "seeds": [
      "Severe intellectual disability and progressive spastic paraplegia"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02361",
    "question": "What is associated with Short QT syndrome 7?",
    "seeds": [
      "Short QT syndrome 7"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02362",
    "question": "What is associated with Bilateral ptosis?",
    "seeds": [
      "Bilateral ptosis"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02363",
    "question": "What phenotype is associated with ANOSMIA?",
    "seeds": [
      "ANOSMIA"
    ],
    "gold_answer": "Anosmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02364",
    "question": "What is associated with Focal impaired awareness epileptic spasm?",
    "seeds": [
      "Focal impaired awareness epileptic spasm"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02365",
    "question": "What phenotype is associated with Autosomal dominant spastic paraplegia type 19?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 19"
    ],
    "gold_answer": "Abnormal lower-limb motor evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02366",
    "question": "What phenotype is associated with Combined oxidative phosphorylation deficiency 19?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 19"
    ],
    "gold_answer": "Esophagitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02367",
    "question": "What is associated with Bloodstream Malaria parasite?",
    "seeds": [
      "Bloodstream Malaria parasite"
    ],
    "gold_answer": "Bloodstream infectious agent",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02368",
    "question": "What is associated with GNE myopathy?",
    "seeds": [
      "GNE myopathy"
    ],
    "gold_answer": "Abnormal wrist physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02369",
    "question": "What is associated with Loss of gluteal subcutaneous adipose tissue?",
    "seeds": [
      "Loss of gluteal subcutaneous adipose tissue"
    ],
    "gold_answer": "Decreased adipose tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02370",
    "question": "What is associated with Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7?",
    "seeds": [
      "Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7"
    ],
    "gold_answer": "Infectious encephalitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02371",
    "question": "What is associated with Hyperconvex fingernails?",
    "seeds": [
      "Hyperconvex fingernails"
    ],
    "gold_answer": "Nail dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02372",
    "question": "What is associated with Deformed forearm bones?",
    "seeds": [
      "Deformed forearm bones"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02373",
    "question": "What phenotype is associated with Hypomagnesemia 3, renal?",
    "seeds": [
      "Hypomagnesemia 3, renal"
    ],
    "gold_answer": "Widely spaced teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02374",
    "question": "What is associated with Fibrotic non-specific interstitial pneumonia?",
    "seeds": [
      "Fibrotic non-specific interstitial pneumonia"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02375",
    "question": "What is associated with Thoracic aorta calcification?",
    "seeds": [
      "Thoracic aorta calcification"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02376",
    "question": "What phenotype is associated with Aortic aneurysm, familial thoracic 9?",
    "seeds": [
      "Aortic aneurysm, familial thoracic 9"
    ],
    "gold_answer": "Arachnodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02377",
    "question": "What is associated with Medullary peritubular capillary lumen organized thrombi?",
    "seeds": [
      "Medullary peritubular capillary lumen organized thrombi"
    ],
    "gold_answer": "Abnormal medullary peritubular capillary lumen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02378",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 20?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 20"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02379",
    "question": "What is associated with Neutropenia, severe congenital, X-linked?",
    "seeds": [
      "Neutropenia, severe congenital, X-linked"
    ],
    "gold_answer": "Abnormal monocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02380",
    "question": "What is associated with Paroxysmal non-kinesigenic dyskinesia?",
    "seeds": [
      "Paroxysmal non-kinesigenic dyskinesia"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02381",
    "question": "What is associated with Gallbladder wall thickening?",
    "seeds": [
      "Gallbladder wall thickening"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02382",
    "question": "What is associated with Liver failure, infantile, transient?",
    "seeds": [
      "Liver failure, infantile, transient"
    ],
    "gold_answer": "Cholestasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02383",
    "question": "What is associated with Lymph-node hemophagocytosis?",
    "seeds": [
      "Lymph-node hemophagocytosis"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02384",
    "question": "What is associated with Retinitis pigmentosa 30?",
    "seeds": [
      "Retinitis pigmentosa 30"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02385",
    "question": "What is associated with Hypoplasia of serratus anterior muscle?",
    "seeds": [
      "Hypoplasia of serratus anterior muscle"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02386",
    "question": "What is associated with Delayed eruption of permanent teeth?",
    "seeds": [
      "Delayed eruption of permanent teeth"
    ],
    "gold_answer": "Delayed eruption of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02387",
    "question": "What is associated with Agenesis of the anterior commissure?",
    "seeds": [
      "Agenesis of the anterior commissure"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02388",
    "question": "What is associated with Ileocecal ulcer?",
    "seeds": [
      "Ileocecal ulcer"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02389",
    "question": "What is associated with Pemphigus vulgaris, familial?",
    "seeds": [
      "Pemphigus vulgaris, familial"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02390",
    "question": "What is associated with Abnormal internal genitalia?",
    "seeds": [
      "Abnormal internal genitalia"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02391",
    "question": "What is associated with Amyotrophic lateral sclerosis 9?",
    "seeds": [
      "Amyotrophic lateral sclerosis 9"
    ],
    "gold_answer": "FUS",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02392",
    "question": "What is associated with Decreased QRS voltage?",
    "seeds": [
      "Decreased QRS voltage"
    ],
    "gold_answer": "Abnormal QRS voltage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02393",
    "question": "What is associated with Spatial pattern?",
    "seeds": [
      "Spatial pattern"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02394",
    "question": "What is associated with Florid cemento-osseous dysplasia?",
    "seeds": [
      "Florid cemento-osseous dysplasia"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02395",
    "question": "What is associated with Craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 2?",
    "seeds": [
      "Craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 2"
    ],
    "gold_answer": "Abnormal sternum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02396",
    "question": "What is associated with Duplication of the distal phalanx of the 4th toe?",
    "seeds": [
      "Duplication of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02397",
    "question": "What phenotype is associated with Brachydactyly, type A2?",
    "seeds": [
      "Brachydactyly, type A2"
    ],
    "gold_answer": "Broad hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02398",
    "question": "What is associated with Pituitary gland cyst?",
    "seeds": [
      "Pituitary gland cyst"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02399",
    "question": "What is associated with Thin vermilion border?",
    "seeds": [
      "Thin vermilion border"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02400",
    "question": "What is associated with Moderate albuminuria?",
    "seeds": [
      "Moderate albuminuria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02401",
    "question": "What is associated with Pulmonary fibrosis and/or bone marrow failure, telomere-related, 4?",
    "seeds": [
      "Pulmonary fibrosis and/or bone marrow failure, telomere-related, 4"
    ],
    "gold_answer": "Abnormal chromosome morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02402",
    "question": "What is associated with Positive CSF mycobacterium tuberculosis nucleic acid test?",
    "seeds": [
      "Positive CSF mycobacterium tuberculosis nucleic acid test"
    ],
    "gold_answer": "Positive CSF infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02403",
    "question": "What is associated with Homocystinuria without methylmalonic aciduria?",
    "seeds": [
      "Homocystinuria without methylmalonic aciduria"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02404",
    "question": "What is associated with Premature epimetaphyseal fusion in hand?",
    "seeds": [
      "Premature epimetaphyseal fusion in hand"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02405",
    "question": "What phenotype is associated with Neurodevelopmental disorder and language delay with or without structural brain abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder and language delay with or without structural brain abnormalities"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02406",
    "question": "What is associated with Gitelman-like kidney tubulopathy due to mitochondrial DNA mutation?",
    "seeds": [
      "Gitelman-like kidney tubulopathy due to mitochondrial DNA mutation"
    ],
    "gold_answer": "MT-TF",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02407",
    "question": "What is associated with Anteverted ears?",
    "seeds": [
      "Anteverted ears"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02408",
    "question": "What phenotype is associated with Neurodegeneration with brain iron accumulation 6?",
    "seeds": [
      "Neurodegeneration with brain iron accumulation 6"
    ],
    "gold_answer": "Abnormality of the temporomandibular joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02409",
    "question": "What is associated with Charcot-Marie-Tooth disease, type 4B3?",
    "seeds": [
      "Charcot-Marie-Tooth disease, type 4B3"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02410",
    "question": "What is associated with Abnormal terminal:vellus ratio?",
    "seeds": [
      "Abnormal terminal:vellus ratio"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02411",
    "question": "What is associated with Helicobacter pylori infection, susceptibility to?",
    "seeds": [
      "Helicobacter pylori infection, susceptibility to"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02412",
    "question": "What is associated with Bilateral cleft palate?",
    "seeds": [
      "Bilateral cleft palate"
    ],
    "gold_answer": "Non-midline cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02413",
    "question": "What phenotype is associated with Ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome?",
    "seeds": [
      "Ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome"
    ],
    "gold_answer": "Dementia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02414",
    "question": "What is associated with Regional right ventricular hypokinesis?",
    "seeds": [
      "Regional right ventricular hypokinesis"
    ],
    "gold_answer": "Abnormal right ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02415",
    "question": "What is associated with Radioulnar interosseous membrane tear?",
    "seeds": [
      "Radioulnar interosseous membrane tear"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02416",
    "question": "What is associated with Abnormal total iron binding capacity?",
    "seeds": [
      "Abnormal total iron binding capacity"
    ],
    "gold_answer": "Abnormal blood transition element cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02417",
    "question": "What is associated with Abnormality of the hand?",
    "seeds": [
      "Abnormality of the hand"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02418",
    "question": "What is associated with Ebstein anomaly of the tricuspid valve?",
    "seeds": [
      "Ebstein anomaly of the tricuspid valve"
    ],
    "gold_answer": "Abnormal heart valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02419",
    "question": "What is associated with Acute otitis media?",
    "seeds": [
      "Acute otitis media"
    ],
    "gold_answer": "Abnormal middle ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02420",
    "question": "What is associated with Exostosis of the external auditory canal?",
    "seeds": [
      "Exostosis of the external auditory canal"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02421",
    "question": "What phenotype is associated with Leber congenital amaurosis 12?",
    "seeds": [
      "Leber congenital amaurosis 12"
    ],
    "gold_answer": "Abnormal macular pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02422",
    "question": "What is associated with Acute kidney injury?",
    "seeds": [
      "Acute kidney injury"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02423",
    "question": "What is associated with Long QT syndrome 11?",
    "seeds": [
      "Long QT syndrome 11"
    ],
    "gold_answer": "Abnormal QT interval",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02424",
    "question": "What is associated with Pontocerebellar hypoplasia, type 5?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 5"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02425",
    "question": "What phenotype is associated with Periventricular nodular heterotopia 7?",
    "seeds": [
      "Periventricular nodular heterotopia 7"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02426",
    "question": "What is associated with Gingivitis?",
    "seeds": [
      "Gingivitis"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02427",
    "question": "What is associated with Pretibial hyperpigmentation?",
    "seeds": [
      "Pretibial hyperpigmentation"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02428",
    "question": "What phenotype is associated with HYPERLEUCINE-ISOLEUCINEMIA?",
    "seeds": [
      "HYPERLEUCINE-ISOLEUCINEMIA"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02429",
    "question": "What is associated with Lamellar pulverulent cataract?",
    "seeds": [
      "Lamellar pulverulent cataract"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02430",
    "question": "What is associated with Epilepsy, focal, with speech disorder and with or without impaired intellectual development?",
    "seeds": [
      "Epilepsy, focal, with speech disorder and with or without impaired intellectual development"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02431",
    "question": "What is associated with Infantile spasms?",
    "seeds": [
      "Infantile spasms"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02432",
    "question": "What is associated with Morning myoclonic jerks?",
    "seeds": [
      "Morning myoclonic jerks"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02433",
    "question": "What is associated with Infantile spasms?",
    "seeds": [
      "Infantile spasms"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02434",
    "question": "What phenotype is associated with Autoimmune polyendocrinopathy type 3?",
    "seeds": [
      "Autoimmune polyendocrinopathy type 3"
    ],
    "gold_answer": "Prostate neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02435",
    "question": "What is associated with Calcium oxalate nephrolithiasis?",
    "seeds": [
      "Calcium oxalate nephrolithiasis"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02436",
    "question": "What is associated with Trisomy 12p syndrome?",
    "seeds": [
      "Trisomy 12p syndrome"
    ],
    "gold_answer": "Eclabion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02437",
    "question": "What is associated with Diarrhea 9?",
    "seeds": [
      "Diarrhea 9"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02438",
    "question": "What is associated with Popliteal cyst?",
    "seeds": [
      "Popliteal cyst"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02439",
    "question": "What is associated with 2q32q33 deletion syndrome?",
    "seeds": [
      "2q32q33 deletion syndrome"
    ],
    "gold_answer": "Abnormal number of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02440",
    "question": "What is associated with Fever?",
    "seeds": [
      "Fever"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02441",
    "question": "What is associated with Abnormal macular morphology?",
    "seeds": [
      "Abnormal macular morphology"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02442",
    "question": "What is associated with Epidermolysis bullosa simplex, generalized, with scarring and hair loss?",
    "seeds": [
      "Epidermolysis bullosa simplex, generalized, with scarring and hair loss"
    ],
    "gold_answer": "Nail dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02443",
    "question": "What is associated with Partial duplication of the phalanges of the 2nd finger?",
    "seeds": [
      "Partial duplication of the phalanges of the 2nd finger"
    ],
    "gold_answer": "Abnormal 2nd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02444",
    "question": "What is associated with Abnormal rib cage morphology?",
    "seeds": [
      "Abnormal rib cage morphology"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02445",
    "question": "What is associated with Immunodeficiency by defective expression of MHC class II?",
    "seeds": [
      "Immunodeficiency by defective expression of MHC class II"
    ],
    "gold_answer": "Abnormal urine cytology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02446",
    "question": "What is associated with Disturbed perception with a stimulus?",
    "seeds": [
      "Disturbed perception with a stimulus"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02447",
    "question": "What is associated with Flat nasal alae?",
    "seeds": [
      "Flat nasal alae"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02448",
    "question": "What is associated with Hip dysplasia, Beukes type?",
    "seeds": [
      "Hip dysplasia, Beukes type"
    ],
    "gold_answer": "Arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02449",
    "question": "What is associated with Anti-GABA(A)R antibody?",
    "seeds": [
      "Anti-GABA(A)R antibody"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02450",
    "question": "What is associated with Pituitary prolactin cell adenoma?",
    "seeds": [
      "Pituitary prolactin cell adenoma"
    ],
    "gold_answer": "Pituitary adenoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02451",
    "question": "What is associated with Abnormal Z disk morphology?",
    "seeds": [
      "Abnormal Z disk morphology"
    ],
    "gold_answer": "Abnormal sarcomere morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02452",
    "question": "What is associated with Mesomelic leg shortening?",
    "seeds": [
      "Mesomelic leg shortening"
    ],
    "gold_answer": "Aplasia/hypoplasia of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02453",
    "question": "What is associated with Familial adenomatous polyposis 4?",
    "seeds": [
      "Familial adenomatous polyposis 4"
    ],
    "gold_answer": "Abnormal thyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02454",
    "question": "What phenotype is associated with Deafness, autosomal recessive 110?",
    "seeds": [
      "Deafness, autosomal recessive 110"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02455",
    "question": "What phenotype is associated with Anemia, dyserythropoietic congenital, type IV?",
    "seeds": [
      "Anemia, dyserythropoietic congenital, type IV"
    ],
    "gold_answer": "Increased RBC distribution width",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02456",
    "question": "What is associated with Anti-voltage-gated potassium channel antibody positivity?",
    "seeds": [
      "Anti-voltage-gated potassium channel antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02457",
    "question": "What is associated with Abnormal cardiac septum morphology?",
    "seeds": [
      "Abnormal cardiac septum morphology"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02458",
    "question": "What is associated with Cerebellar hemangioblastoma?",
    "seeds": [
      "Cerebellar hemangioblastoma"
    ],
    "gold_answer": "Hemangioblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02459",
    "question": "What is associated with Abnormality of circulating fibrinogen?",
    "seeds": [
      "Abnormality of circulating fibrinogen"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02460",
    "question": "What is associated with MAN1B1-CDG?",
    "seeds": [
      "MAN1B1-CDG"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02461",
    "question": "What is associated with Decreased pituitary glycoprotein hormone alpha subunit level?",
    "seeds": [
      "Decreased pituitary glycoprotein hormone alpha subunit level"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02462",
    "question": "What is associated with EEG with central focal spikes?",
    "seeds": [
      "EEG with central focal spikes"
    ],
    "gold_answer": "EEG with focal epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02463",
    "question": "What is associated with Braddock syndrome?",
    "seeds": [
      "Braddock syndrome"
    ],
    "gold_answer": "Elevated pulmonary artery pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02464",
    "question": "What is associated with Abnormal hyoglossus muscle morphology?",
    "seeds": [
      "Abnormal hyoglossus muscle morphology"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02465",
    "question": "What is associated with Abnormality of the alternative complement pathway?",
    "seeds": [
      "Abnormality of the alternative complement pathway"
    ],
    "gold_answer": "Abnormality of complement system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02466",
    "question": "What is associated with Chronic monilial nail infection?",
    "seeds": [
      "Chronic monilial nail infection"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02467",
    "question": "What is associated with Cervical spina bifida?",
    "seeds": [
      "Cervical spina bifida"
    ],
    "gold_answer": "Spinal dysraphism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02468",
    "question": "What is associated with Proximal tibial hypoplasia?",
    "seeds": [
      "Proximal tibial hypoplasia"
    ],
    "gold_answer": "Short tibia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02469",
    "question": "What phenotype is associated with Anemia, X-linked, with or without neutropenia and/or platelet abnormalities?",
    "seeds": [
      "Anemia, X-linked, with or without neutropenia and/or platelet abnormalities"
    ],
    "gold_answer": "Bone marrow hypocellularity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02470",
    "question": "What is associated with Fractured middle phalanx of manual digit 3?",
    "seeds": [
      "Fractured middle phalanx of manual digit 3"
    ],
    "gold_answer": "Fractured manual digit bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02471",
    "question": "What is associated with Christmas tree cataract?",
    "seeds": [
      "Christmas tree cataract"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02472",
    "question": "What is associated with Focal sensory seizure?",
    "seeds": [
      "Focal sensory seizure"
    ],
    "gold_answer": "Non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02473",
    "question": "What is associated with Lacunar halos around chondrocytes?",
    "seeds": [
      "Lacunar halos around chondrocytes"
    ],
    "gold_answer": "Abnormal cartilage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02474",
    "question": "What phenotype is associated with 46,xx sex reversal 4?",
    "seeds": [
      "46,xx sex reversal 4"
    ],
    "gold_answer": "Ovotestis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02475",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 59?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 59"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02476",
    "question": "What is associated with Abnormal platelet granules?",
    "seeds": [
      "Abnormal platelet granules"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02477",
    "question": "What is associated with Respiratory insufficiency?",
    "seeds": [
      "Respiratory insufficiency"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02478",
    "question": "What is associated with Elevated urine glycolate?",
    "seeds": [
      "Elevated urine glycolate"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02479",
    "question": "What is associated with Phthisis bulbi?",
    "seeds": [
      "Phthisis bulbi"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02480",
    "question": "What phenotype is associated with Myotonia fluctuans?",
    "seeds": [
      "Myotonia fluctuans"
    ],
    "gold_answer": "Myotonia of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02481",
    "question": "What is associated with Pancreatic fibrosis?",
    "seeds": [
      "Pancreatic fibrosis"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02482",
    "question": "What is associated with Recurrent bacterial meningitis?",
    "seeds": [
      "Recurrent bacterial meningitis"
    ],
    "gold_answer": "Recurrent meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02483",
    "question": "What is associated with OTOSCLEROSIS?",
    "seeds": [
      "OTOSCLEROSIS"
    ],
    "gold_answer": "Functional abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02484",
    "question": "What is associated with Radial deviation of the hand or of fingers of the hand?",
    "seeds": [
      "Radial deviation of the hand or of fingers of the hand"
    ],
    "gold_answer": "Deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02485",
    "question": "What is associated with Impaired phorbol myristate acetate-induced platelet aggregation?",
    "seeds": [
      "Impaired phorbol myristate acetate-induced platelet aggregation"
    ],
    "gold_answer": "Abnormal platelet function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02486",
    "question": "What is associated with Moderate hearing impairment?",
    "seeds": [
      "Moderate hearing impairment"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02487",
    "question": "What phenotype is associated with Motion sickness?",
    "seeds": [
      "Motion sickness"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02488",
    "question": "What phenotype is associated with Acquired idiopathic sideroblastic anemia?",
    "seeds": [
      "Acquired idiopathic sideroblastic anemia"
    ],
    "gold_answer": "Myelodysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02489",
    "question": "What phenotype is associated with Pierre Robin syndrome?",
    "seeds": [
      "Pierre Robin syndrome"
    ],
    "gold_answer": "Glossoptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02490",
    "question": "What is associated with Bracket epiphysis of the distal phalanx of the 4th finger?",
    "seeds": [
      "Bracket epiphysis of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the distal phalanx of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02491",
    "question": "What is associated with Paranoia?",
    "seeds": [
      "Paranoia"
    ],
    "gold_answer": "Disorder of thought content",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02492",
    "question": "What is associated with Palmar pruritus?",
    "seeds": [
      "Palmar pruritus"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02493",
    "question": "What is associated with Persistent bleeding after trauma?",
    "seeds": [
      "Persistent bleeding after trauma"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02494",
    "question": "What is associated with Duplication of phalanx of 5th finger?",
    "seeds": [
      "Duplication of phalanx of 5th finger"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02495",
    "question": "What is associated with Distal 22q11.2 microduplication syndrome?",
    "seeds": [
      "Distal 22q11.2 microduplication syndrome"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02496",
    "question": "What is associated with Absent lunula?",
    "seeds": [
      "Absent lunula"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02497",
    "question": "What is associated with Transient hyperlipidemia?",
    "seeds": [
      "Transient hyperlipidemia"
    ],
    "gold_answer": "Hyperlipidemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02498",
    "question": "What is associated with Nephronophthisis 12?",
    "seeds": [
      "Nephronophthisis 12"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02499",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 24?",
    "seeds": [
      "Ciliary dyskinesia, primary, 24"
    ],
    "gold_answer": "Decreased nasal nitric oxide",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02500",
    "question": "What is associated with Paucity of peroxisomes?",
    "seeds": [
      "Paucity of peroxisomes"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02501",
    "question": "What is associated with Anti-U1 ribonucleoprotein antibody positivity?",
    "seeds": [
      "Anti-U1 ribonucleoprotein antibody positivity"
    ],
    "gold_answer": "Extractable nuclear antigen positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02502",
    "question": "What is associated with Neuronal loss in basal ganglia?",
    "seeds": [
      "Neuronal loss in basal ganglia"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02503",
    "question": "What is associated with Bullet-shaped proximal phalanx of the hallux?",
    "seeds": [
      "Bullet-shaped proximal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02504",
    "question": "What is associated with Short finger?",
    "seeds": [
      "Short finger"
    ],
    "gold_answer": "Short digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02505",
    "question": "What is associated with Absent epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Absent epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Absent epiphyses of the proximal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02506",
    "question": "What is associated with Underfolded superior helices?",
    "seeds": [
      "Underfolded superior helices"
    ],
    "gold_answer": "Abnormally folded helix",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02507",
    "question": "What is associated with Multicentric osteolysis-nodulosis-arthropathy spectrum?",
    "seeds": [
      "Multicentric osteolysis-nodulosis-arthropathy spectrum"
    ],
    "gold_answer": "Abnormality of globe location",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02508",
    "question": "What is associated with Rudimentary to absent tibiae?",
    "seeds": [
      "Rudimentary to absent tibiae"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the tibia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02509",
    "question": "What is associated with Goldberg-Shprintzen megacolon syndrome?",
    "seeds": [
      "Goldberg-Shprintzen megacolon syndrome"
    ],
    "gold_answer": "Coloboma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02510",
    "question": "What phenotype is associated with Short stature-webbed neck-heart disease syndrome?",
    "seeds": [
      "Short stature-webbed neck-heart disease syndrome"
    ],
    "gold_answer": "Short neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02511",
    "question": "What is associated with Neuropathic pain?",
    "seeds": [
      "Neuropathic pain"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02512",
    "question": "What is associated with Peroxisome biogenesis disorder 11B?",
    "seeds": [
      "Peroxisome biogenesis disorder 11B"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02513",
    "question": "What is associated with Nodular pattern on pulmonary HRCT?",
    "seeds": [
      "Nodular pattern on pulmonary HRCT"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02514",
    "question": "What is associated with Asymmetric short stature?",
    "seeds": [
      "Asymmetric short stature"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02515",
    "question": "What is associated with Lymphangiectasis?",
    "seeds": [
      "Lymphangiectasis"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02516",
    "question": "What is associated with Abnormal brainstem white matter morphology?",
    "seeds": [
      "Abnormal brainstem white matter morphology"
    ],
    "gold_answer": "Abnormal brainstem morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02517",
    "question": "What is associated with Immunodeficiency 119?",
    "seeds": [
      "Immunodeficiency 119"
    ],
    "gold_answer": "Verrucae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02518",
    "question": "What is associated with Renal tubular basement membrane denudation?",
    "seeds": [
      "Renal tubular basement membrane denudation"
    ],
    "gold_answer": "Abnormal tubular basement membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02519",
    "question": "What phenotype is associated with Gyrate atrophy of choroid and retina?",
    "seeds": [
      "Gyrate atrophy of choroid and retina"
    ],
    "gold_answer": "Subcapsular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02520",
    "question": "What is associated with Delayed patellar ossification?",
    "seeds": [
      "Delayed patellar ossification"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02521",
    "question": "What is associated with DNAJB6-related distal myopathy?",
    "seeds": [
      "DNAJB6-related distal myopathy"
    ],
    "gold_answer": "DNAJB6",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02522",
    "question": "What is associated with Abnormal choroid plexus morphology?",
    "seeds": [
      "Abnormal choroid plexus morphology"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02523",
    "question": "What is associated with Trigonocephaly?",
    "seeds": [
      "Trigonocephaly"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02524",
    "question": "What is associated with Recurrent oral herpes?",
    "seeds": [
      "Recurrent oral herpes"
    ],
    "gold_answer": "Unusual viral infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02525",
    "question": "What is associated with Abnormal upper lip morphology?",
    "seeds": [
      "Abnormal upper lip morphology"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02526",
    "question": "What phenotype is associated with Intellectual disability-dysmorphism-hypogonadism-diabetes mellitus syndrome?",
    "seeds": [
      "Intellectual disability-dysmorphism-hypogonadism-diabetes mellitus syndrome"
    ],
    "gold_answer": "Wide nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02527",
    "question": "What phenotype is associated with Adams-Oliver syndrome 5?",
    "seeds": [
      "Adams-Oliver syndrome 5"
    ],
    "gold_answer": "Dystrophic toenail",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02528",
    "question": "What is associated with Diminished circulating reduced nicotinamide adenine dinucleotide (NADH) concentration?",
    "seeds": [
      "Diminished circulating reduced nicotinamide adenine dinucleotide (NADH) concentration"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02529",
    "question": "What is associated with Hypothyroidism, congenital, nongoitrous, 2?",
    "seeds": [
      "Hypothyroidism, congenital, nongoitrous, 2"
    ],
    "gold_answer": "Abnormal umbilicus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02530",
    "question": "What is associated with Large vessel vasculitis?",
    "seeds": [
      "Large vessel vasculitis"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02531",
    "question": "What is associated with Abnormal penis morphology?",
    "seeds": [
      "Abnormal penis morphology"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02532",
    "question": "What is associated with Deafness, autosomal recessive 99?",
    "seeds": [
      "Deafness, autosomal recessive 99"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02533",
    "question": "What is associated with Focal segmental glomerulosclerosis 6?",
    "seeds": [
      "Focal segmental glomerulosclerosis 6"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02534",
    "question": "What is associated with Sebaceous gland carcinoma?",
    "seeds": [
      "Sebaceous gland carcinoma"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02535",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 4?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 4"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02536",
    "question": "What is associated with Small bowel diverticula?",
    "seeds": [
      "Small bowel diverticula"
    ],
    "gold_answer": "Abnormal small intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02537",
    "question": "What is associated with Chin with H-shaped crease?",
    "seeds": [
      "Chin with H-shaped crease"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02538",
    "question": "What is associated with Polymicrogyria due to TUBB2B mutation?",
    "seeds": [
      "Polymicrogyria due to TUBB2B mutation"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02539",
    "question": "What is associated with Abnormal middle ear morphology?",
    "seeds": [
      "Abnormal middle ear morphology"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02540",
    "question": "What is associated with Multiple mitochondrial dysfunctions syndrome 5?",
    "seeds": [
      "Multiple mitochondrial dysfunctions syndrome 5"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02541",
    "question": "What is associated with Perifollicular hyperkeratosis?",
    "seeds": [
      "Perifollicular hyperkeratosis"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02542",
    "question": "What phenotype is associated with Formiminoglutamic aciduria?",
    "seeds": [
      "Formiminoglutamic aciduria"
    ],
    "gold_answer": "Abnormal enzyme/coenzyme activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02543",
    "question": "What is associated with Nail dysplasia?",
    "seeds": [
      "Nail dysplasia"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02544",
    "question": "What is associated with Achlorhydria?",
    "seeds": [
      "Achlorhydria"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02545",
    "question": "What is associated with Resistance to trivial environmental changes?",
    "seeds": [
      "Resistance to trivial environmental changes"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02546",
    "question": "What phenotype is associated with Subacute cutaneous lupus erythematosus?",
    "seeds": [
      "Subacute cutaneous lupus erythematosus"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02547",
    "question": "What is associated with EMG: axonal abnormality?",
    "seeds": [
      "EMG: axonal abnormality"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02548",
    "question": "What is associated with Prominent superficial veins?",
    "seeds": [
      "Prominent superficial veins"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02549",
    "question": "What is associated with Hypoplastic vertebral bodies?",
    "seeds": [
      "Hypoplastic vertebral bodies"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02550",
    "question": "What is associated with Rapid-onset dystonia-parkinsonism?",
    "seeds": [
      "Rapid-onset dystonia-parkinsonism"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02551",
    "question": "What is associated with Retinal shunt vessels?",
    "seeds": [
      "Retinal shunt vessels"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02552",
    "question": "What is associated with Bullet-shaped 3rd toe phalanx?",
    "seeds": [
      "Bullet-shaped 3rd toe phalanx"
    ],
    "gold_answer": "Abnormal third toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02553",
    "question": "What is associated with Abnormal pulse pressure?",
    "seeds": [
      "Abnormal pulse pressure"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02554",
    "question": "What is associated with Dopamine beta-hydroxylase deficiency?",
    "seeds": [
      "Dopamine beta-hydroxylase deficiency"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02555",
    "question": "What phenotype is associated with IgG4-related dacryoadenitis and sialadenitis?",
    "seeds": [
      "IgG4-related dacryoadenitis and sialadenitis"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02556",
    "question": "What is associated with Anti-acetylcholine receptor antibody positivity?",
    "seeds": [
      "Anti-acetylcholine receptor antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02557",
    "question": "What is associated with Febrile seizures, familial, 4?",
    "seeds": [
      "Febrile seizures, familial, 4"
    ],
    "gold_answer": "Tonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02558",
    "question": "What is associated with Positive CSF JC-virus antibody positivity?",
    "seeds": [
      "Positive CSF JC-virus antibody positivity"
    ],
    "gold_answer": "CSF pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02559",
    "question": "What is associated with 3-5 finger cutaneous syndactyly?",
    "seeds": [
      "3-5 finger cutaneous syndactyly"
    ],
    "gold_answer": "3-5 finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02560",
    "question": "What is associated with Abnormal 5th metacarpal morphology?",
    "seeds": [
      "Abnormal 5th metacarpal morphology"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02561",
    "question": "What is associated with Double uterus-hemivagina-renal agenesis syndrome?",
    "seeds": [
      "Double uterus-hemivagina-renal agenesis syndrome"
    ],
    "gold_answer": "Septate vagina",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02562",
    "question": "What is associated with Rectovestibular fistula?",
    "seeds": [
      "Rectovestibular fistula"
    ],
    "gold_answer": "Rectal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02563",
    "question": "What is associated with Cleft palate-large ears-small head syndrome?",
    "seeds": [
      "Cleft palate-large ears-small head syndrome"
    ],
    "gold_answer": "Deviation of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02564",
    "question": "What is associated with Chorioretinal hyperpigmentation?",
    "seeds": [
      "Chorioretinal hyperpigmentation"
    ],
    "gold_answer": "Abnormality of chorioretinal pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02565",
    "question": "What is associated with Abnormality of peripheral nervous system electrophysiology?",
    "seeds": [
      "Abnormality of peripheral nervous system electrophysiology"
    ],
    "gold_answer": "Abnormal nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02566",
    "question": "What is associated with Unusual infection by anatomical site?",
    "seeds": [
      "Unusual infection by anatomical site"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02567",
    "question": "What is associated with Complete duplication of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Complete duplication of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02568",
    "question": "What is associated with Vocal cord polyp?",
    "seeds": [
      "Vocal cord polyp"
    ],
    "gold_answer": "Abnormal vocal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02569",
    "question": "What is associated with Urogenital fistula?",
    "seeds": [
      "Urogenital fistula"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02570",
    "question": "What is associated with Camptodactyly of 2nd-5th fingers?",
    "seeds": [
      "Camptodactyly of 2nd-5th fingers"
    ],
    "gold_answer": "Flexion contracture of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02571",
    "question": "What is associated with Familial advanced sleep-phase syndrome?",
    "seeds": [
      "Familial advanced sleep-phase syndrome"
    ],
    "gold_answer": "PER3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02572",
    "question": "What is associated with Cerebral creatine deficiency syndrome 2?",
    "seeds": [
      "Cerebral creatine deficiency syndrome 2"
    ],
    "gold_answer": "Seizure precipitated by febrile infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02573",
    "question": "What is associated with Absent phalangeal crease?",
    "seeds": [
      "Absent phalangeal crease"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02574",
    "question": "What phenotype is associated with Microcephaly and chorioretinopathy, autosomal recessive, 1?",
    "seeds": [
      "Microcephaly and chorioretinopathy, autosomal recessive, 1"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02575",
    "question": "What is associated with Prolonged REM sleep?",
    "seeds": [
      "Prolonged REM sleep"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02576",
    "question": "What is associated with Abnormal genital pigmentation?",
    "seeds": [
      "Abnormal genital pigmentation"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02577",
    "question": "What is associated with Gallbladder disease 4?",
    "seeds": [
      "Gallbladder disease 4"
    ],
    "gold_answer": "Abnormality of the gallbladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02578",
    "question": "What is associated with Deficiency or absence of cytochrome b(-245)?",
    "seeds": [
      "Deficiency or absence of cytochrome b(-245)"
    ],
    "gold_answer": "Abnormality of mitochondrial metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02579",
    "question": "What is associated with DPAGT1-CDG?",
    "seeds": [
      "DPAGT1-CDG"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02580",
    "question": "What is associated with Spastic paraplegia 75, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 75, autosomal recessive"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02581",
    "question": "What is associated with Iris cyst?",
    "seeds": [
      "Iris cyst"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02582",
    "question": "What is associated with Peripheral dysostosis?",
    "seeds": [
      "Peripheral dysostosis"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02583",
    "question": "What is associated with Osteoporosis-pseudoglioma syndrome?",
    "seeds": [
      "Osteoporosis-pseudoglioma syndrome"
    ],
    "gold_answer": "Yellow/white retinal lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02584",
    "question": "What is associated with Decreased Th1 T cell proportion?",
    "seeds": [
      "Decreased Th1 T cell proportion"
    ],
    "gold_answer": "Abnormal T cell physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02585",
    "question": "What phenotype is associated with Deafness, autosomal recessive 4, with enlarged vestibular aqueduct?",
    "seeds": [
      "Deafness, autosomal recessive 4, with enlarged vestibular aqueduct"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02586",
    "question": "What is associated with Myopathy, mitochondrial, and ataxia?",
    "seeds": [
      "Myopathy, mitochondrial, and ataxia"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02587",
    "question": "What is associated with Absent forearm bone?",
    "seeds": [
      "Absent forearm bone"
    ],
    "gold_answer": "Aplasia/hypoplasia involving forearm bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02588",
    "question": "What is associated with Abnormal fetal abdominal circumference?",
    "seeds": [
      "Abnormal fetal abdominal circumference"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02589",
    "question": "What is associated with Alzheimer disease 4?",
    "seeds": [
      "Alzheimer disease 4"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02590",
    "question": "What is associated with Duplication of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Duplication of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02591",
    "question": "What is associated with Abnormal muscle fiber desmin?",
    "seeds": [
      "Abnormal muscle fiber desmin"
    ],
    "gold_answer": "Abnormal muscle fiber protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02592",
    "question": "What is associated with Long palm?",
    "seeds": [
      "Long palm"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02593",
    "question": "What phenotype is associated with Choroidal atrophy-alopecia syndrome?",
    "seeds": [
      "Choroidal atrophy-alopecia syndrome"
    ],
    "gold_answer": "Sparse or absent eyelashes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02594",
    "question": "What is associated with Leber congenital amaurosis 8?",
    "seeds": [
      "Leber congenital amaurosis 8"
    ],
    "gold_answer": "Abnormal choroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02595",
    "question": "What is associated with Calcium channel blocker exposure?",
    "seeds": [
      "Calcium channel blocker exposure"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02596",
    "question": "What is associated with Bronchial telangiectasia?",
    "seeds": [
      "Bronchial telangiectasia"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02597",
    "question": "What phenotype is associated with Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline?",
    "seeds": [
      "Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02598",
    "question": "What is associated with N-acetylglutamate synthase deficiency?",
    "seeds": [
      "N-acetylglutamate synthase deficiency"
    ],
    "gold_answer": "Abnormality of temperature regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02599",
    "question": "What is associated with Primary CD59 deficiency?",
    "seeds": [
      "Primary CD59 deficiency"
    ],
    "gold_answer": "CD59",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02600",
    "question": "What is associated with Frontal lobe dementia?",
    "seeds": [
      "Frontal lobe dementia"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02601",
    "question": "What is associated with Deafness, autosomal dominant nonsyndromic sensorineural 5?",
    "seeds": [
      "Deafness, autosomal dominant nonsyndromic sensorineural 5"
    ],
    "gold_answer": "Progressive hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02602",
    "question": "What is associated with Decreased circulating heparan sulfate level?",
    "seeds": [
      "Decreased circulating heparan sulfate level"
    ],
    "gold_answer": "Abnormal circulating carbohydrate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02603",
    "question": "What is associated with Iris pigment dispersion?",
    "seeds": [
      "Iris pigment dispersion"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02604",
    "question": "What is associated with Cone-rod dystrophy 15?",
    "seeds": [
      "Cone-rod dystrophy 15"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02605",
    "question": "What is associated with Epilepsy, familial temporal lobe, 6?",
    "seeds": [
      "Epilepsy, familial temporal lobe, 6"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02606",
    "question": "What is associated with Ivory epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Ivory epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02607",
    "question": "What is associated with Eosinophilic granulomatosis with polyangiitis?",
    "seeds": [
      "Eosinophilic granulomatosis with polyangiitis"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02608",
    "question": "What is associated with Hypophosphatasia, childhood?",
    "seeds": [
      "Hypophosphatasia, childhood"
    ],
    "gold_answer": "Bowing of the long bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02609",
    "question": "What phenotype is associated with Keratosis follicularis spinulosa decalvans, X-linked?",
    "seeds": [
      "Keratosis follicularis spinulosa decalvans, X-linked"
    ],
    "gold_answer": "Keratitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02610",
    "question": "What phenotype is associated with Glycerol kinase deficiency?",
    "seeds": [
      "Glycerol kinase deficiency"
    ],
    "gold_answer": "Vomiting",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02611",
    "question": "What is associated with Hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities?",
    "seeds": [
      "Hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities"
    ],
    "gold_answer": "Lower-limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02612",
    "question": "What is associated with Decreased circulating complement C4a concentration?",
    "seeds": [
      "Decreased circulating complement C4a concentration"
    ],
    "gold_answer": "Reduced circulating complement concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02613",
    "question": "What is associated with Localized hirsutism?",
    "seeds": [
      "Localized hirsutism"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02614",
    "question": "What is associated with X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome?",
    "seeds": [
      "X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome"
    ],
    "gold_answer": "Abnormally folded helix",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02615",
    "question": "What is associated with Large posterior fontanelle?",
    "seeds": [
      "Large posterior fontanelle"
    ],
    "gold_answer": "Abnormal cranial suture/fontanelle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02616",
    "question": "What is associated with Abnormal morphology of the pelvis musculature?",
    "seeds": [
      "Abnormal morphology of the pelvis musculature"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02617",
    "question": "What phenotype is associated with Moyamoya disease?",
    "seeds": [
      "Moyamoya disease"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02618",
    "question": "What is associated with Polydactyly affecting the 4th toe?",
    "seeds": [
      "Polydactyly affecting the 4th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02619",
    "question": "What is associated with Single trichilemmoma?",
    "seeds": [
      "Single trichilemmoma"
    ],
    "gold_answer": "Skin appendage neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02620",
    "question": "What is associated with Moyamoya phenomenon?",
    "seeds": [
      "Moyamoya phenomenon"
    ],
    "gold_answer": "Abnormal cerebral artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02621",
    "question": "What phenotype is associated with 46XY sex reversal 5?",
    "seeds": [
      "46XY sex reversal 5"
    ],
    "gold_answer": "Abnormality of circulating cortisol level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02622",
    "question": "What is associated with Decreased peak expiratory flow?",
    "seeds": [
      "Decreased peak expiratory flow"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02623",
    "question": "What is associated with Isolated optic neuritis?",
    "seeds": [
      "Isolated optic neuritis"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02624",
    "question": "What is associated with Deafness with labyrinthine aplasia, microtia, and microdontia?",
    "seeds": [
      "Deafness with labyrinthine aplasia, microtia, and microdontia"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02625",
    "question": "What is associated with Brachydactyly, type A2, with microcephaly?",
    "seeds": [
      "Brachydactyly, type A2, with microcephaly"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02626",
    "question": "What is associated with Faciocardiomelic syndrome?",
    "seeds": [
      "Faciocardiomelic syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the skull",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02627",
    "question": "What is associated with Infection due to encapsulated bacteria?",
    "seeds": [
      "Infection due to encapsulated bacteria"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02628",
    "question": "What is associated with Ejection click?",
    "seeds": [
      "Ejection click"
    ],
    "gold_answer": "Abnormal heart sound",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02629",
    "question": "What is associated with Focal aware pedal automatism seizure?",
    "seeds": [
      "Focal aware pedal automatism seizure"
    ],
    "gold_answer": "Focal automatism seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02630",
    "question": "What is associated with Hypothyroidism, congenital, nongoitrous, 1?",
    "seeds": [
      "Hypothyroidism, congenital, nongoitrous, 1"
    ],
    "gold_answer": "Skeletal muscle hypertrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02631",
    "question": "What is associated with Elevated blood bismuth concentration?",
    "seeds": [
      "Elevated blood bismuth concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02632",
    "question": "What is associated with Abnormal muscle fiber dystrophin expression?",
    "seeds": [
      "Abnormal muscle fiber dystrophin expression"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02633",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 9?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 9"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02634",
    "question": "What is associated with TRIM32-related limb-girdle muscular dystrophy R8?",
    "seeds": [
      "TRIM32-related limb-girdle muscular dystrophy R8"
    ],
    "gold_answer": "Abnormal circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02635",
    "question": "What is associated with Spinal muscular atrophy-Dandy-Walker malformation-cataracts syndrome?",
    "seeds": [
      "Spinal muscular atrophy-Dandy-Walker malformation-cataracts syndrome"
    ],
    "gold_answer": "Enlarged posterior fossa",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02636",
    "question": "What is associated with Parkinson disease 19a, juvenile-onset?",
    "seeds": [
      "Parkinson disease 19a, juvenile-onset"
    ],
    "gold_answer": "Inability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02637",
    "question": "What is associated with Neoplasm of the pituitary gland?",
    "seeds": [
      "Neoplasm of the pituitary gland"
    ],
    "gold_answer": "Abnormal pituitary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02638",
    "question": "What is associated with Cortical peritubular capillary lumen cholesterol emboli?",
    "seeds": [
      "Cortical peritubular capillary lumen cholesterol emboli"
    ],
    "gold_answer": "Abnormal cortical peritubular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02639",
    "question": "What phenotype is associated with Polycystic kidney disease, infantile severe, with tuberous sclerosis?",
    "seeds": [
      "Polycystic kidney disease, infantile severe, with tuberous sclerosis"
    ],
    "gold_answer": "Cortical tubers",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02640",
    "question": "What is associated with Areolar fullness?",
    "seeds": [
      "Areolar fullness"
    ],
    "gold_answer": "Abnormal areolar morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02641",
    "question": "What is associated with Abnormal metacarpophalangeal joint morphology?",
    "seeds": [
      "Abnormal metacarpophalangeal joint morphology"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02642",
    "question": "What is associated with Spinocerebellar ataxia 13?",
    "seeds": [
      "Spinocerebellar ataxia 13"
    ],
    "gold_answer": "Abnormal optic disc morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02643",
    "question": "What is associated with Abnormal circulating deoxycorticosterone level?",
    "seeds": [
      "Abnormal circulating deoxycorticosterone level"
    ],
    "gold_answer": "Abnormal circulating corticosterone level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02644",
    "question": "What is associated with Hemangioma-Thrombocytopenia syndrome?",
    "seeds": [
      "Hemangioma-Thrombocytopenia syndrome"
    ],
    "gold_answer": "Abnormal platelet count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02645",
    "question": "What is associated with Harderoporphyria?",
    "seeds": [
      "Harderoporphyria"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02646",
    "question": "What is associated with Tremor, hereditary essential, 6?",
    "seeds": [
      "Tremor, hereditary essential, 6"
    ],
    "gold_answer": "Action tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02647",
    "question": "What is associated with Abnormal buccal mucosa cell morphology?",
    "seeds": [
      "Abnormal buccal mucosa cell morphology"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02648",
    "question": "What is associated with Abnormal Z disk morphology?",
    "seeds": [
      "Abnormal Z disk morphology"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02649",
    "question": "What is associated with Abnormal circulating homocysteine concentration?",
    "seeds": [
      "Abnormal circulating homocysteine concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02650",
    "question": "What phenotype is associated with 46,XX sex reversal 5?",
    "seeds": [
      "46,XX sex reversal 5"
    ],
    "gold_answer": "Urogenital sinus anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02651",
    "question": "What phenotype is associated with Spondyloepimetaphyseal dysplasia, Guo-Campeau type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, Guo-Campeau type"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02652",
    "question": "What is associated with Increased CSF glutamate concentration?",
    "seeds": [
      "Increased CSF glutamate concentration"
    ],
    "gold_answer": "Abnormal CSF glutamine family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02653",
    "question": "What is associated with Microtia-anotia?",
    "seeds": [
      "Microtia-anotia"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02654",
    "question": "What is associated with Lower limb undergrowth?",
    "seeds": [
      "Lower limb undergrowth"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02655",
    "question": "What is associated with Anomalous origin of the left anterior descending artery from the pulmonary artery?",
    "seeds": [
      "Anomalous origin of the left anterior descending artery from the pulmonary artery"
    ],
    "gold_answer": "Abnormal coronary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02656",
    "question": "What is associated with T-wave alternans?",
    "seeds": [
      "T-wave alternans"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02657",
    "question": "What is associated with Hypercalciuria, absorptive, susceptibility to?",
    "seeds": [
      "Hypercalciuria, absorptive, susceptibility to"
    ],
    "gold_answer": "Nephrolithiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02658",
    "question": "What phenotype is associated with Baraitser-Winter syndrome 2?",
    "seeds": [
      "Baraitser-Winter syndrome 2"
    ],
    "gold_answer": "Retrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02659",
    "question": "What is associated with Prolonged G2 phase of cell cycle?",
    "seeds": [
      "Prolonged G2 phase of cell cycle"
    ],
    "gold_answer": "Abnormality of the cell cycle",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02660",
    "question": "What phenotype is associated with Locked-in syndrome?",
    "seeds": [
      "Locked-in syndrome"
    ],
    "gold_answer": "Abnormality of the voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02661",
    "question": "What is associated with Lens subluxation?",
    "seeds": [
      "Lens subluxation"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02662",
    "question": "What is associated with Ejection click?",
    "seeds": [
      "Ejection click"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02663",
    "question": "What is associated with Podagra?",
    "seeds": [
      "Podagra"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02664",
    "question": "What is associated with Abnormality of the distal radial epiphysis?",
    "seeds": [
      "Abnormality of the distal radial epiphysis"
    ],
    "gold_answer": "Abnormal limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02665",
    "question": "What is associated with Reduced volume of central subdivision of bed nucleus of stria terminalis?",
    "seeds": [
      "Reduced volume of central subdivision of bed nucleus of stria terminalis"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02666",
    "question": "What is associated with Myoclonus-dystonia syndrome?",
    "seeds": [
      "Myoclonus-dystonia syndrome"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02667",
    "question": "What is associated with 9q31.1q31.3 microdeletion syndrome?",
    "seeds": [
      "9q31.1q31.3 microdeletion syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the clavicles",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02668",
    "question": "What is associated with Macular degeneration, age-related, 7?",
    "seeds": [
      "Macular degeneration, age-related, 7"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02669",
    "question": "What is associated with Abnormal morphology of the proximal phalanx of the 3rd toe?",
    "seeds": [
      "Abnormal morphology of the proximal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormality of toe proximal phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02670",
    "question": "What is associated with Megaepiphyseal dwarfism?",
    "seeds": [
      "Megaepiphyseal dwarfism"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02671",
    "question": "What phenotype is associated with AICA-ribosiduria?",
    "seeds": [
      "AICA-ribosiduria"
    ],
    "gold_answer": "Wide mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02672",
    "question": "What is associated with Reduced CD95-induced lymphocyte apoptosis?",
    "seeds": [
      "Reduced CD95-induced lymphocyte apoptosis"
    ],
    "gold_answer": "Decreased T cell apoptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02673",
    "question": "What phenotype is associated with Oculodental syndrome, Rutherfurd type?",
    "seeds": [
      "Oculodental syndrome, Rutherfurd type"
    ],
    "gold_answer": "Abnormal dental morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02674",
    "question": "What is associated with Reduced muscle telethonin level?",
    "seeds": [
      "Reduced muscle telethonin level"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02675",
    "question": "What phenotype is associated with Oculocerebral syndrome with hypopigmentation?",
    "seeds": [
      "Oculocerebral syndrome with hypopigmentation"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02676",
    "question": "What is associated with Febrile seizures, familial, 4?",
    "seeds": [
      "Febrile seizures, familial, 4"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02677",
    "question": "What is associated with Fragmented elastic fibers in the dermis?",
    "seeds": [
      "Fragmented elastic fibers in the dermis"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02678",
    "question": "What is associated with Digital pitting scar?",
    "seeds": [
      "Digital pitting scar"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02679",
    "question": "What is associated with Optic disc pallor?",
    "seeds": [
      "Optic disc pallor"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02680",
    "question": "What is associated with Lethargy?",
    "seeds": [
      "Lethargy"
    ],
    "gold_answer": "Abnormal diminished volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02681",
    "question": "What is associated with Joint flexor surface localization?",
    "seeds": [
      "Joint flexor surface localization"
    ],
    "gold_answer": "Localized",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02682",
    "question": "What is associated with Proximal limb muscle stiffness?",
    "seeds": [
      "Proximal limb muscle stiffness"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02683",
    "question": "What phenotype is associated with Temple syndrome due to paternal 14q32.2 hypomethylation?",
    "seeds": [
      "Temple syndrome due to paternal 14q32.2 hypomethylation"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02684",
    "question": "What is associated with Radiographic modifier?",
    "seeds": [
      "Radiographic modifier"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02685",
    "question": "What phenotype is associated with Orofaciodigital syndrome type 4?",
    "seeds": [
      "Orofaciodigital syndrome type 4"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the tibia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02686",
    "question": "What is associated with Aplasia of the parotid gland?",
    "seeds": [
      "Aplasia of the parotid gland"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02687",
    "question": "What is associated with Corneal dystrophy, endothelial, X-linked?",
    "seeds": [
      "Corneal dystrophy, endothelial, X-linked"
    ],
    "gold_answer": "Central opacification of the cornea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02688",
    "question": "What phenotype is associated with Cleft palate-stapes fixation-oligodontia syndrome?",
    "seeds": [
      "Cleft palate-stapes fixation-oligodontia syndrome"
    ],
    "gold_answer": "Delayed eruption of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02689",
    "question": "What is associated with Infrequent social engagement with peers?",
    "seeds": [
      "Infrequent social engagement with peers"
    ],
    "gold_answer": "Abnormal social development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02690",
    "question": "What is associated with B-CELL MALIGNANCY, LOW-GRADE?",
    "seeds": [
      "B-CELL MALIGNANCY, LOW-GRADE"
    ],
    "gold_answer": "Chronic leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02691",
    "question": "What is associated with Linear IgG deposits along the epidermal basement membrane zone?",
    "seeds": [
      "Linear IgG deposits along the epidermal basement membrane zone"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02692",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 35?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 35"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02693",
    "question": "What is associated with Abnormal cortical peritubular capillary morphology?",
    "seeds": [
      "Abnormal cortical peritubular capillary morphology"
    ],
    "gold_answer": "Abnormal renal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02694",
    "question": "What is associated with Perisylvian polymicrogyria?",
    "seeds": [
      "Perisylvian polymicrogyria"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02695",
    "question": "What is associated with Absent scaphoid?",
    "seeds": [
      "Absent scaphoid"
    ],
    "gold_answer": "Carpal bone aplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02696",
    "question": "What is associated with Neurodegeneration, early-childhood-onset, with retinitis pigmentosa, sensorineural hearing loss, and demyelinating peripheral neuropathy?",
    "seeds": [
      "Neurodegeneration, early-childhood-onset, with retinitis pigmentosa, sensorineural hearing loss, and demyelinating peripheral neuropathy"
    ],
    "gold_answer": "Long-tract sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02697",
    "question": "What is associated with Ivory epiphyses of the 5th finger?",
    "seeds": [
      "Ivory epiphyses of the 5th finger"
    ],
    "gold_answer": "Ivory epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02698",
    "question": "What is associated with Decreased circulating creatine kinase concentration?",
    "seeds": [
      "Decreased circulating creatine kinase concentration"
    ],
    "gold_answer": "Abnormal circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02699",
    "question": "What is associated with Type 1 and type 2 muscle fiber minicore regions?",
    "seeds": [
      "Type 1 and type 2 muscle fiber minicore regions"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02700",
    "question": "What is associated with Decreased proportion of central memory CD4-positive T cells?",
    "seeds": [
      "Decreased proportion of central memory CD4-positive T cells"
    ],
    "gold_answer": "Abnormal CD4+ memory T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02701",
    "question": "What is associated with Reduced epidermal collagen IV protein expression?",
    "seeds": [
      "Reduced epidermal collagen IV protein expression"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02702",
    "question": "What is associated with Absent thoracic vertebra?",
    "seeds": [
      "Absent thoracic vertebra"
    ],
    "gold_answer": "Absent vertebra",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02703",
    "question": "What phenotype is associated with Mesothelioma, malignant?",
    "seeds": [
      "Mesothelioma, malignant"
    ],
    "gold_answer": "Malignant mesothelioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02704",
    "question": "What is associated with Abnormal pancreas morphology?",
    "seeds": [
      "Abnormal pancreas morphology"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02705",
    "question": "What is associated with Autosomal dominant Charcot-Marie-Tooth disease type 2V?",
    "seeds": [
      "Autosomal dominant Charcot-Marie-Tooth disease type 2V"
    ],
    "gold_answer": "NAGLU",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02706",
    "question": "What phenotype is associated with Glaucoma 3, primary infantile, B?",
    "seeds": [
      "Glaucoma 3, primary infantile, B"
    ],
    "gold_answer": "Primary congenital glaucoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02707",
    "question": "What is associated with Elevated circulating cholesterol sulfate concentration?",
    "seeds": [
      "Elevated circulating cholesterol sulfate concentration"
    ],
    "gold_answer": "Abnormal circulating cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02708",
    "question": "What is associated with Multiple epiphyseal dysplasia type 5?",
    "seeds": [
      "Multiple epiphyseal dysplasia type 5"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02709",
    "question": "What is associated with Vesicoallantoic abdominal wall defect?",
    "seeds": [
      "Vesicoallantoic abdominal wall defect"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02710",
    "question": "What is associated with Duodenal diverticula?",
    "seeds": [
      "Duodenal diverticula"
    ],
    "gold_answer": "Bowel diverticulosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02711",
    "question": "What is associated with Decreased number of large peripheral myelinated nerve fibers?",
    "seeds": [
      "Decreased number of large peripheral myelinated nerve fibers"
    ],
    "gold_answer": "Abnormal peripheral myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02712",
    "question": "What is associated with Increased total T cell count?",
    "seeds": [
      "Increased total T cell count"
    ],
    "gold_answer": "Abnormal total T cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02713",
    "question": "What is associated with Fetal neck mass?",
    "seeds": [
      "Fetal neck mass"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02714",
    "question": "What is associated with Temporal lobe calcification?",
    "seeds": [
      "Temporal lobe calcification"
    ],
    "gold_answer": "Cerebral calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02715",
    "question": "What is associated with Ulnar hypoplasia-split foot syndrome?",
    "seeds": [
      "Ulnar hypoplasia-split foot syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the ulna",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02716",
    "question": "What is associated with Abnormal urinary hypoxanthine level?",
    "seeds": [
      "Abnormal urinary hypoxanthine level"
    ],
    "gold_answer": "Abnormal urinary purine level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02717",
    "question": "What is associated with Increased circulating hemoglobin concentration?",
    "seeds": [
      "Increased circulating hemoglobin concentration"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02718",
    "question": "What phenotype is associated with Gingival fibromatosis-facial dysmorphism syndrome?",
    "seeds": [
      "Gingival fibromatosis-facial dysmorphism syndrome"
    ],
    "gold_answer": "Exaggerated cupid's bow",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02719",
    "question": "What is associated with Sleep-wake inversion?",
    "seeds": [
      "Sleep-wake inversion"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02720",
    "question": "What is associated with Myeloid maturation arrest?",
    "seeds": [
      "Myeloid maturation arrest"
    ],
    "gold_answer": "Bone marrow maturation arrest",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02721",
    "question": "What is associated with Polydactyly affecting the 4th finger?",
    "seeds": [
      "Polydactyly affecting the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02722",
    "question": "What is associated with Pseudohypoaldosteronism, type IID?",
    "seeds": [
      "Pseudohypoaldosteronism, type IID"
    ],
    "gold_answer": "Abnormal blood monovalent inorganic cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02723",
    "question": "What is associated with Stimmler syndrome?",
    "seeds": [
      "Stimmler syndrome"
    ],
    "gold_answer": "Glucose intolerance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02724",
    "question": "What is associated with Spermatogenic failure 73?",
    "seeds": [
      "Spermatogenic failure 73"
    ],
    "gold_answer": "Infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02725",
    "question": "What phenotype is associated with Prostate cancer, susceptibility to?",
    "seeds": [
      "Prostate cancer, susceptibility to"
    ],
    "gold_answer": "Prostate cancer",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02726",
    "question": "What is associated with Inclusion body myopathy with Paget disease of bone and frontotemporal dementia?",
    "seeds": [
      "Inclusion body myopathy with Paget disease of bone and frontotemporal dementia"
    ],
    "gold_answer": "Abnormal neuron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02727",
    "question": "What is associated with Periventricular nodular heterotopia 6?",
    "seeds": [
      "Periventricular nodular heterotopia 6"
    ],
    "gold_answer": "FLNA",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_test_02728",
    "question": "What is associated with Nephrotic syndrome, type 5, with or without ocular abnormalities?",
    "seeds": [
      "Nephrotic syndrome, type 5, with or without ocular abnormalities"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02729",
    "question": "What is associated with Achoo syndrome?",
    "seeds": [
      "Achoo syndrome"
    ],
    "gold_answer": "Sneeze",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02730",
    "question": "What is associated with Increased circulating dehydroepiandrosterone concentration?",
    "seeds": [
      "Increased circulating dehydroepiandrosterone concentration"
    ],
    "gold_answer": "Abnormal circulating dehydroepiandrosterone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02731",
    "question": "What is associated with Defective B cell activation?",
    "seeds": [
      "Defective B cell activation"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02732",
    "question": "What is associated with Increased circulating apolipoprotein circulation?",
    "seeds": [
      "Increased circulating apolipoprotein circulation"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02733",
    "question": "What is associated with Positive O'Brien active compression test?",
    "seeds": [
      "Positive O'Brien active compression test"
    ],
    "gold_answer": "Positive provocative functional shoulder test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02734",
    "question": "What is associated with Thyroid C cell hyperplasia?",
    "seeds": [
      "Thyroid C cell hyperplasia"
    ],
    "gold_answer": "Abnormal thyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02735",
    "question": "What is associated with Hypercholanemia, familial?",
    "seeds": [
      "Hypercholanemia, familial"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02736",
    "question": "What is associated with Colonic stenosis?",
    "seeds": [
      "Colonic stenosis"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02737",
    "question": "What is associated with Chess-pawn distal phalanges?",
    "seeds": [
      "Chess-pawn distal phalanges"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02738",
    "question": "What is associated with 4-hydroxyphenylacetic aciduria?",
    "seeds": [
      "4-hydroxyphenylacetic aciduria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02739",
    "question": "What phenotype is associated with Tyrosinemia type 2?",
    "seeds": [
      "Tyrosinemia type 2"
    ],
    "gold_answer": "Corneal opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02740",
    "question": "What is associated with Melkersson-Rosenthal syndrome?",
    "seeds": [
      "Melkersson-Rosenthal syndrome"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02741",
    "question": "What is associated with Joint contracture of the 4th finger?",
    "seeds": [
      "Joint contracture of the 4th finger"
    ],
    "gold_answer": "Flexion contracture of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02742",
    "question": "What is associated with Hydrocephalus, congenital, 2, with or without brain or eye anomalies?",
    "seeds": [
      "Hydrocephalus, congenital, 2, with or without brain or eye anomalies"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02743",
    "question": "What is associated with Hilar lymph node enlargement?",
    "seeds": [
      "Hilar lymph node enlargement"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02744",
    "question": "What is associated with Increased radioactive iodine uptake?",
    "seeds": [
      "Increased radioactive iodine uptake"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02745",
    "question": "What is associated with Abnormal muscle fiber protein expression?",
    "seeds": [
      "Abnormal muscle fiber protein expression"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02746",
    "question": "What is associated with Plasma fibronectin deficiency?",
    "seeds": [
      "Plasma fibronectin deficiency"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02747",
    "question": "What phenotype is associated with Adrenocortical carcinoma with pure aldosterone hypersecretion?",
    "seeds": [
      "Adrenocortical carcinoma with pure aldosterone hypersecretion"
    ],
    "gold_answer": "Metabolic alkalosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02748",
    "question": "What is associated with Congenital peripheral neuropathy?",
    "seeds": [
      "Congenital peripheral neuropathy"
    ],
    "gold_answer": "Abnormality of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02749",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 73?",
    "seeds": [
      "Developmental and epileptic encephalopathy 73"
    ],
    "gold_answer": "Irritability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02750",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 98?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 98"
    ],
    "gold_answer": "Short nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02751",
    "question": "What is associated with Wolfram-like syndrome, autosomal dominant?",
    "seeds": [
      "Wolfram-like syndrome, autosomal dominant"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02752",
    "question": "What is associated with Immobile lump?",
    "seeds": [
      "Immobile lump"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02753",
    "question": "What is associated with Increased circulating vitamin E concentration?",
    "seeds": [
      "Increased circulating vitamin E concentration"
    ],
    "gold_answer": "Abnormal metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02754",
    "question": "What is associated with Metacarpal periosteal thickening?",
    "seeds": [
      "Metacarpal periosteal thickening"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02755",
    "question": "What phenotype is associated with Immunodeficiency 42?",
    "seeds": [
      "Immunodeficiency 42"
    ],
    "gold_answer": "Abnormality of the vagina",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02756",
    "question": "What is associated with Pleural cyst?",
    "seeds": [
      "Pleural cyst"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02757",
    "question": "What is associated with Impaired ADP-induced platelet aggregation?",
    "seeds": [
      "Impaired ADP-induced platelet aggregation"
    ],
    "gold_answer": "Abnormal platelet function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02758",
    "question": "What phenotype is associated with Otosclerosis 7?",
    "seeds": [
      "Otosclerosis 7"
    ],
    "gold_answer": "Childhood onset sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02759",
    "question": "What is associated with Neurodevelopmental disorder with language delay and variable cognitive abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with language delay and variable cognitive abnormalities"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02760",
    "question": "What is associated with Abnormal circulating proANP concentration?",
    "seeds": [
      "Abnormal circulating proANP concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02761",
    "question": "What is associated with Pinhole visual acuity 3.0 LogMAR?",
    "seeds": [
      "Pinhole visual acuity 3.0 LogMAR"
    ],
    "gold_answer": "Abnormal pinhole visual acuity test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02762",
    "question": "What is associated with Retinitis pigmentosa with or without skeletal anomalies?",
    "seeds": [
      "Retinitis pigmentosa with or without skeletal anomalies"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02763",
    "question": "What is associated with Apical hypertrophic cardiomyopathy?",
    "seeds": [
      "Apical hypertrophic cardiomyopathy"
    ],
    "gold_answer": "Hypertrophic cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02764",
    "question": "What is associated with Brain malformation renal syndrome?",
    "seeds": [
      "Brain malformation renal syndrome"
    ],
    "gold_answer": "Abnormal skull base morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02765",
    "question": "What is associated with Epicanthus tarsalis?",
    "seeds": [
      "Epicanthus tarsalis"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02766",
    "question": "What is associated with Glomerular capillary wall duplication with cellular interposition?",
    "seeds": [
      "Glomerular capillary wall duplication with cellular interposition"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02767",
    "question": "What phenotype is associated with Alpha-N-acetylgalactosaminidase deficiency type 3?",
    "seeds": [
      "Alpha-N-acetylgalactosaminidase deficiency type 3"
    ],
    "gold_answer": "Hepatomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02768",
    "question": "What is associated with Fractured metaphysis of femur?",
    "seeds": [
      "Fractured metaphysis of femur"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02769",
    "question": "What is associated with Chess-pawn distal phalanges?",
    "seeds": [
      "Chess-pawn distal phalanges"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02770",
    "question": "What is associated with Recurrent distressing nightmares?",
    "seeds": [
      "Recurrent distressing nightmares"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02771",
    "question": "What is associated with Myeloschisis?",
    "seeds": [
      "Myeloschisis"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02772",
    "question": "What phenotype is associated with Malaria?",
    "seeds": [
      "Malaria"
    ],
    "gold_answer": "Respiratory distress",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02773",
    "question": "What is associated with Normal pressure hydrocephalus?",
    "seeds": [
      "Normal pressure hydrocephalus"
    ],
    "gold_answer": "Abnormal cerebral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02774",
    "question": "What is associated with Neurodegeneration, infantile-onset, biotin-responsive?",
    "seeds": [
      "Neurodegeneration, infantile-onset, biotin-responsive"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02775",
    "question": "What is associated with Rhomboid or triangular shaped 5th finger middle phalanx?",
    "seeds": [
      "Rhomboid or triangular shaped 5th finger middle phalanx"
    ],
    "gold_answer": "Triangular shaped middle phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02776",
    "question": "What is associated with Abnormal cutaneous collagen fibril morphology?",
    "seeds": [
      "Abnormal cutaneous collagen fibril morphology"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02777",
    "question": "What is associated with Leber congenital amaurosis with early-onset deafness?",
    "seeds": [
      "Leber congenital amaurosis with early-onset deafness"
    ],
    "gold_answer": "Diffuse optic disc pallor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02778",
    "question": "What is associated with Thin ribs-tubular bones-dysmorphism syndrome?",
    "seeds": [
      "Thin ribs-tubular bones-dysmorphism syndrome"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02779",
    "question": "What is associated with Venular insufficiency, systemic?",
    "seeds": [
      "Venular insufficiency, systemic"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02780",
    "question": "What is associated with Proptosis?",
    "seeds": [
      "Proptosis"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02781",
    "question": "What is associated with Cerebellar medulloblastoma?",
    "seeds": [
      "Cerebellar medulloblastoma"
    ],
    "gold_answer": "Medulloblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02782",
    "question": "What is associated with Pleuritic chest pain?",
    "seeds": [
      "Pleuritic chest pain"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02783",
    "question": "What is associated with Patent ductus arteriosus 2?",
    "seeds": [
      "Patent ductus arteriosus 2"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02784",
    "question": "What is associated with Enlarged tectum?",
    "seeds": [
      "Enlarged tectum"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02785",
    "question": "What is associated with Reduced granulocyte CD18 level?",
    "seeds": [
      "Reduced granulocyte CD18 level"
    ],
    "gold_answer": "Reduced granulocyte surface marker level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02786",
    "question": "What is associated with Pancreatic hypoplasia?",
    "seeds": [
      "Pancreatic hypoplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02787",
    "question": "What is associated with Constipation?",
    "seeds": [
      "Constipation"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02788",
    "question": "What phenotype is associated with Frasier syndrome?",
    "seeds": [
      "Frasier syndrome"
    ],
    "gold_answer": "Gonadoblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02789",
    "question": "What phenotype is associated with Spastic paraplegia 64, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 64, autosomal recessive"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02790",
    "question": "What phenotype is associated with Pelvic dysplasia - arthrogryposis of lower limbs?",
    "seeds": [
      "Pelvic dysplasia - arthrogryposis of lower limbs"
    ],
    "gold_answer": "Lumbar hyperlordosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02791",
    "question": "What is associated with Abnormal circulating mannose-binding protein concentration?",
    "seeds": [
      "Abnormal circulating mannose-binding protein concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02792",
    "question": "What is associated with Spermatogenic failure, X-linked, 3?",
    "seeds": [
      "Spermatogenic failure, X-linked, 3"
    ],
    "gold_answer": "Decreased fertility in males",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02793",
    "question": "What is associated with Weak extraocular muscles?",
    "seeds": [
      "Weak extraocular muscles"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02794",
    "question": "What is associated with Mucinous neoplasm?",
    "seeds": [
      "Mucinous neoplasm"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02795",
    "question": "What is associated with Descending aorta hypoplasia?",
    "seeds": [
      "Descending aorta hypoplasia"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02796",
    "question": "What is associated with Sudden cardiac death?",
    "seeds": [
      "Sudden cardiac death"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02797",
    "question": "What is associated with Triangular shaped proximal phalanx of the 4th finger?",
    "seeds": [
      "Triangular shaped proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02798",
    "question": "What is associated with Arthritis?",
    "seeds": [
      "Arthritis"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02799",
    "question": "What is associated with Childhood onset short-limb short stature?",
    "seeds": [
      "Childhood onset short-limb short stature"
    ],
    "gold_answer": "Disproportionate short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02800",
    "question": "What is associated with T-wave inversion?",
    "seeds": [
      "T-wave inversion"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02801",
    "question": "What is associated with Spermatogonial maturation arrest?",
    "seeds": [
      "Spermatogonial maturation arrest"
    ],
    "gold_answer": "Spermatogenesis maturation arrest",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02802",
    "question": "What is associated with Focal impaired awareness cognitive seizure with neglect?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with neglect"
    ],
    "gold_answer": "Focal impaired awareness seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02803",
    "question": "What is associated with Reduced circulating interleukin 9 concentration?",
    "seeds": [
      "Reduced circulating interleukin 9 concentration"
    ],
    "gold_answer": "Abnormal circulating interleukin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02804",
    "question": "What is associated with Diffuse skin atrophy?",
    "seeds": [
      "Diffuse skin atrophy"
    ],
    "gold_answer": "Dermal atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02805",
    "question": "What is associated with Blood group A?",
    "seeds": [
      "Blood group A"
    ],
    "gold_answer": "ABO blood group",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02806",
    "question": "What is associated with Facial expressions not directed to others?",
    "seeds": [
      "Facial expressions not directed to others"
    ],
    "gold_answer": "Abnormal nonverbal communicative behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02807",
    "question": "What is associated with Hyperpigmentation of eyelids?",
    "seeds": [
      "Hyperpigmentation of eyelids"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02808",
    "question": "What phenotype is associated with Nelson syndrome?",
    "seeds": [
      "Nelson syndrome"
    ],
    "gold_answer": "Spinal cord lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02809",
    "question": "What is associated with Lacrimal duct atresia?",
    "seeds": [
      "Lacrimal duct atresia"
    ],
    "gold_answer": "Abnormal nasolacrimal system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02810",
    "question": "What phenotype is associated with Epidermolysis bullosa with deficiency of galactosylhydroxylysyl glucosyltransferase?",
    "seeds": [
      "Epidermolysis bullosa with deficiency of galactosylhydroxylysyl glucosyltransferase"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02811",
    "question": "What is associated with Dull?",
    "seeds": [
      "Dull"
    ],
    "gold_answer": "Pain characteristic",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02812",
    "question": "What is associated with Periventricular heterotopia?",
    "seeds": [
      "Periventricular heterotopia"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02813",
    "question": "What is associated with Enlarged uterus?",
    "seeds": [
      "Enlarged uterus"
    ],
    "gold_answer": "Abnormal uterus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02814",
    "question": "What is associated with Abnormal left ventricular endsystolic diameter?",
    "seeds": [
      "Abnormal left ventricular endsystolic diameter"
    ],
    "gold_answer": "Abnormal cardiac ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02815",
    "question": "What is associated with Pneumobilia?",
    "seeds": [
      "Pneumobilia"
    ],
    "gold_answer": "Abnormal biliary tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02816",
    "question": "What is associated with Splenogonadal fusion?",
    "seeds": [
      "Splenogonadal fusion"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02817",
    "question": "What is associated with EEG with central sharp waves?",
    "seeds": [
      "EEG with central sharp waves"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02818",
    "question": "What phenotype is associated with Calvarial doughnut lesions with bone fragility?",
    "seeds": [
      "Calvarial doughnut lesions with bone fragility"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02819",
    "question": "What is associated with Trigonocephaly?",
    "seeds": [
      "Trigonocephaly"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02820",
    "question": "What is associated with Increased proportion of central memory CD4-positive T cells?",
    "seeds": [
      "Increased proportion of central memory CD4-positive T cells"
    ],
    "gold_answer": "Abnormal CD4+ T cell subset proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02821",
    "question": "What is associated with Cholesterol emboli within interlobular vein lumen?",
    "seeds": [
      "Cholesterol emboli within interlobular vein lumen"
    ],
    "gold_answer": "Abnormal intrarenal vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02822",
    "question": "What is associated with Azoospermia, obstructive, with nephrolithiasis?",
    "seeds": [
      "Azoospermia, obstructive, with nephrolithiasis"
    ],
    "gold_answer": "Infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02823",
    "question": "What phenotype is associated with Regional odontodysplasia?",
    "seeds": [
      "Regional odontodysplasia"
    ],
    "gold_answer": "Abnormality of primary teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02824",
    "question": "What is associated with Multiple-finger involvement?",
    "seeds": [
      "Multiple-finger involvement"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02825",
    "question": "What is associated with Abnormal circulating acylcarnitine concentration?",
    "seeds": [
      "Abnormal circulating acylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating monocarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02826",
    "question": "What is associated with Abnormal fontanelle morphology?",
    "seeds": [
      "Abnormal fontanelle morphology"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02827",
    "question": "What phenotype is associated with Myotonia fluctuans?",
    "seeds": [
      "Myotonia fluctuans"
    ],
    "gold_answer": "Laryngospasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02828",
    "question": "What is associated with Toe, fifth, number of phalanges in?",
    "seeds": [
      "Toe, fifth, number of phalanges in"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02829",
    "question": "What is associated with Delayed membranous cranial ossification?",
    "seeds": [
      "Delayed membranous cranial ossification"
    ],
    "gold_answer": "Abnormal shape of the occiput",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02830",
    "question": "What is associated with Elevated urine pyridinoline level?",
    "seeds": [
      "Elevated urine pyridinoline level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02831",
    "question": "What is associated with Neurogenic arthrogryposis multiplex congenita?",
    "seeds": [
      "Neurogenic arthrogryposis multiplex congenita"
    ],
    "gold_answer": "Joint dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02832",
    "question": "What phenotype is associated with Ovarian hyperstimulation syndrome?",
    "seeds": [
      "Ovarian hyperstimulation syndrome"
    ],
    "gold_answer": "Ovarian cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02833",
    "question": "What is associated with Charcot-Marie-Tooth disease, X-linked recessive, 3?",
    "seeds": [
      "Charcot-Marie-Tooth disease, X-linked recessive, 3"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02834",
    "question": "What is associated with Monosomy 22 syndrome?",
    "seeds": [
      "Monosomy 22 syndrome"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02835",
    "question": "What is associated with Noonan syndrome 14?",
    "seeds": [
      "Noonan syndrome 14"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02836",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 10?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 10"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02837",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 6?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 6"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02838",
    "question": "What phenotype is associated with Pachyonychia congenita 4?",
    "seeds": [
      "Pachyonychia congenita 4"
    ],
    "gold_answer": "Steatocystoma multiplex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02839",
    "question": "What is associated with Freezing of gait?",
    "seeds": [
      "Freezing of gait"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02840",
    "question": "What is associated with Tonic pupil?",
    "seeds": [
      "Tonic pupil"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02841",
    "question": "What is associated with Recurrent respiratory infections?",
    "seeds": [
      "Recurrent respiratory infections"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02842",
    "question": "What is associated with Cholesterol crystalluria?",
    "seeds": [
      "Cholesterol crystalluria"
    ],
    "gold_answer": "Crystalluria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02843",
    "question": "What is associated with Abnormality of fibrinolysis?",
    "seeds": [
      "Abnormality of fibrinolysis"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02844",
    "question": "What is associated with Abnormal femoral epiphysis morphology?",
    "seeds": [
      "Abnormal femoral epiphysis morphology"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02845",
    "question": "What is associated with Short-rib thoracic dysplasia 22 without polydactyly?",
    "seeds": [
      "Short-rib thoracic dysplasia 22 without polydactyly"
    ],
    "gold_answer": "Abnormality of the pylorus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02846",
    "question": "What is associated with Vasculitis in the skin?",
    "seeds": [
      "Vasculitis in the skin"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02847",
    "question": "What is associated with Hypoleucinemia?",
    "seeds": [
      "Hypoleucinemia"
    ],
    "gold_answer": "Abnormal circulating leucine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02848",
    "question": "What is associated with EEG with 4-5/second background activity?",
    "seeds": [
      "EEG with 4-5/second background activity"
    ],
    "gold_answer": "EEG with constitutional variants",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02849",
    "question": "What is associated with Enlarged amygdala?",
    "seeds": [
      "Enlarged amygdala"
    ],
    "gold_answer": "Abnormal amygdala morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02850",
    "question": "What is associated with Spastic paraplegia 37, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 37, autosomal dominant"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02851",
    "question": "What is associated with Pontocerebellar hypoplasia, type 1F?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 1F"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02852",
    "question": "What is associated with Mitochondrial DNA depletion syndrome 11?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 11"
    ],
    "gold_answer": "Nausea and vomiting",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02853",
    "question": "What is associated with Impaired thrombin-induced platelet aggregation?",
    "seeds": [
      "Impaired thrombin-induced platelet aggregation"
    ],
    "gold_answer": "Abnormal platelet aggregation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02854",
    "question": "What is associated with Hyperargininemia?",
    "seeds": [
      "Hyperargininemia"
    ],
    "gold_answer": "Abnormal circulating glutamine family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02855",
    "question": "What is associated with Bullet-shaped middle phalanx of the 4th finger?",
    "seeds": [
      "Bullet-shaped middle phalanx of the 4th finger"
    ],
    "gold_answer": "Bullet-shaped phalanges of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02856",
    "question": "What is associated with Mycobacterium abscessus abscessus infection?",
    "seeds": [
      "Mycobacterium abscessus abscessus infection"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02857",
    "question": "What is associated with Abnormal circulating lipoprotein lipase concentration?",
    "seeds": [
      "Abnormal circulating lipoprotein lipase concentration"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02858",
    "question": "What is associated with Abnormal nervous system electrophysiology?",
    "seeds": [
      "Abnormal nervous system electrophysiology"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02859",
    "question": "What is associated with Cortical radial artery leukocyte hypercellularity?",
    "seeds": [
      "Cortical radial artery leukocyte hypercellularity"
    ],
    "gold_answer": "Abnormal cortical radial artery endothelium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02860",
    "question": "What is associated with Alveolar capillary dysplasia?",
    "seeds": [
      "Alveolar capillary dysplasia"
    ],
    "gold_answer": "Abnormal pulmonary alveolar system development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02861",
    "question": "What phenotype is associated with Desmoid tumor?",
    "seeds": [
      "Desmoid tumor"
    ],
    "gold_answer": "Fibroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02862",
    "question": "What is associated with Chronic irritative conjunctivitis?",
    "seeds": [
      "Chronic irritative conjunctivitis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02863",
    "question": "What is associated with Abnormality of lower limb joint?",
    "seeds": [
      "Abnormality of lower limb joint"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02864",
    "question": "What is associated with Abnormal corneal thickness?",
    "seeds": [
      "Abnormal corneal thickness"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02865",
    "question": "What is associated with Coved type ST segment elevation?",
    "seeds": [
      "Coved type ST segment elevation"
    ],
    "gold_answer": "Abnormal ST segment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02866",
    "question": "What is associated with Decreased urinary biopterin level?",
    "seeds": [
      "Decreased urinary biopterin level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02867",
    "question": "What is associated with Increased femoral anteversion?",
    "seeds": [
      "Increased femoral anteversion"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02868",
    "question": "What is associated with Anti-voltage-gated potassium channel antibody positivity?",
    "seeds": [
      "Anti-voltage-gated potassium channel antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02869",
    "question": "What phenotype is associated with Idiopathic camptocormia?",
    "seeds": [
      "Idiopathic camptocormia"
    ],
    "gold_answer": "Atrial septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02870",
    "question": "What is associated with Anti-CASPR2?",
    "seeds": [
      "Anti-CASPR2"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02871",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 7?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 7"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02872",
    "question": "What phenotype is associated with Cortical dysplasia, complex, with other brain malformations 12?",
    "seeds": [
      "Cortical dysplasia, complex, with other brain malformations 12"
    ],
    "gold_answer": "Premature birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02873",
    "question": "What is associated with Deafness, autosomal recessive 70?",
    "seeds": [
      "Deafness, autosomal recessive 70"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02874",
    "question": "What is associated with Abnormal blood inorganic cation concentration?",
    "seeds": [
      "Abnormal blood inorganic cation concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02875",
    "question": "What is associated with Abnormal septum pellucidum morphology?",
    "seeds": [
      "Abnormal septum pellucidum morphology"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02876",
    "question": "What is associated with 2-4 finger cutaneous syndactyly?",
    "seeds": [
      "2-4 finger cutaneous syndactyly"
    ],
    "gold_answer": "Syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02877",
    "question": "What is associated with Uric acid urolithiasis independent of gout?",
    "seeds": [
      "Uric acid urolithiasis independent of gout"
    ],
    "gold_answer": "Uric acid nephrolithiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02878",
    "question": "What is associated with Bladder fistula?",
    "seeds": [
      "Bladder fistula"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02879",
    "question": "What is associated with Joint extensor surface localization?",
    "seeds": [
      "Joint extensor surface localization"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02880",
    "question": "What is associated with Thyroid dysgenesis?",
    "seeds": [
      "Thyroid dysgenesis"
    ],
    "gold_answer": "Abnormal thyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02881",
    "question": "What is associated with Vocal cord paralysis?",
    "seeds": [
      "Vocal cord paralysis"
    ],
    "gold_answer": "Vocal cord dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02882",
    "question": "What is associated with Plummer-Vinson syndrome?",
    "seeds": [
      "Plummer-Vinson syndrome"
    ],
    "gold_answer": "Abnormal tongue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02883",
    "question": "What phenotype is associated with Thrombocytopenia 1?",
    "seeds": [
      "Thrombocytopenia 1"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02884",
    "question": "What is associated with Crigler-Najjar syndrome, type II?",
    "seeds": [
      "Crigler-Najjar syndrome, type II"
    ],
    "gold_answer": "Abnormal circulating bilirubin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02885",
    "question": "What is associated with Abnormal circulating ornithine concentration?",
    "seeds": [
      "Abnormal circulating ornithine concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02886",
    "question": "What phenotype is associated with Pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures?",
    "seeds": [
      "Pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures"
    ],
    "gold_answer": "Synophrys",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02887",
    "question": "What is associated with Dysplastic aortic valve?",
    "seeds": [
      "Dysplastic aortic valve"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02888",
    "question": "What is associated with Increased sialylation of N-linked protein glycosylation?",
    "seeds": [
      "Increased sialylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein N-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02889",
    "question": "What is associated with Abnormal von Willebrand factor multimer distribution?",
    "seeds": [
      "Abnormal von Willebrand factor multimer distribution"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02890",
    "question": "What is associated with Developmental cataract?",
    "seeds": [
      "Developmental cataract"
    ],
    "gold_answer": "Ocular anterior segment dysgenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02891",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 28?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 28"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02892",
    "question": "What is associated with Unilateral ptosis?",
    "seeds": [
      "Unilateral ptosis"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02893",
    "question": "What is associated with Abnormal fetal pulmonary morphology?",
    "seeds": [
      "Abnormal fetal pulmonary morphology"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02894",
    "question": "What is associated with Missing ribs?",
    "seeds": [
      "Missing ribs"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02895",
    "question": "What is associated with Positive CSF Borrelia burgdorferi nucleic acid test?",
    "seeds": [
      "Positive CSF Borrelia burgdorferi nucleic acid test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02896",
    "question": "What is associated with Protanopia?",
    "seeds": [
      "Protanopia"
    ],
    "gold_answer": "Dyschromatopsia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02897",
    "question": "What phenotype is associated with Thanatophoric dysplasia, glasgow variant?",
    "seeds": [
      "Thanatophoric dysplasia, glasgow variant"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02898",
    "question": "What is associated with Neuromuscular disease and ocular or auditory anomalies with or without seizures?",
    "seeds": [
      "Neuromuscular disease and ocular or auditory anomalies with or without seizures"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02899",
    "question": "What is associated with Reflex asystolic syncope?",
    "seeds": [
      "Reflex asystolic syncope"
    ],
    "gold_answer": "Syncope",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02900",
    "question": "What is associated with T-cell immunodeficiency with thymic aplasia?",
    "seeds": [
      "T-cell immunodeficiency with thymic aplasia"
    ],
    "gold_answer": "Abnormal circulating calcium concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02901",
    "question": "What is associated with Anejaculation?",
    "seeds": [
      "Anejaculation"
    ],
    "gold_answer": "Abnormal male reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02902",
    "question": "What is associated with Urate-Binding globulin, decrease in?",
    "seeds": [
      "Urate-Binding globulin, decrease in"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02903",
    "question": "What is associated with Craniofrontonasal dysplasia?",
    "seeds": [
      "Craniofrontonasal dysplasia"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02904",
    "question": "What is associated with Salzmann corneal nodules?",
    "seeds": [
      "Salzmann corneal nodules"
    ],
    "gold_answer": "Corneal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02905",
    "question": "What is associated with Focal impaired awareness cognitive seizure with dyslexia/alexia?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with dyslexia/alexia"
    ],
    "gold_answer": "Focal impaired awareness non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02906",
    "question": "What is associated with Decreased need for sleep?",
    "seeds": [
      "Decreased need for sleep"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02907",
    "question": "What is associated with Triangular shaped middle phalanges of the toes?",
    "seeds": [
      "Triangular shaped middle phalanges of the toes"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02908",
    "question": "What is associated with Sclerotic forearm bones?",
    "seeds": [
      "Sclerotic forearm bones"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02909",
    "question": "What is associated with Large hands?",
    "seeds": [
      "Large hands"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02910",
    "question": "What is associated with Central centrifugal cicatricial alopecia?",
    "seeds": [
      "Central centrifugal cicatricial alopecia"
    ],
    "gold_answer": "Scarring",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02911",
    "question": "What is associated with Panner disease?",
    "seeds": [
      "Panner disease"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02912",
    "question": "What is associated with Mucous membrane pemphigoid?",
    "seeds": [
      "Mucous membrane pemphigoid"
    ],
    "gold_answer": "Abnormality of the gingiva",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02913",
    "question": "What is associated with Retinitis pigmentosa, X-linked, and sinorespiratory infections, withor without deafness?",
    "seeds": [
      "Retinitis pigmentosa, X-linked, and sinorespiratory infections, withor without deafness"
    ],
    "gold_answer": "Recurrent lower respiratory tract infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02914",
    "question": "What is associated with KDM3B-related intellectual disability-facial dysmorphism-short stature syndrome?",
    "seeds": [
      "KDM3B-related intellectual disability-facial dysmorphism-short stature syndrome"
    ],
    "gold_answer": "KDM3B",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02915",
    "question": "What is associated with Elevated circulating CA19-9 concentration?",
    "seeds": [
      "Elevated circulating CA19-9 concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02916",
    "question": "What is associated with Hyperimmunoglobulinemia D with periodic fever?",
    "seeds": [
      "Hyperimmunoglobulinemia D with periodic fever"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02917",
    "question": "What is associated with Vaginal pruritus?",
    "seeds": [
      "Vaginal pruritus"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02918",
    "question": "What is associated with Myokymia?",
    "seeds": [
      "Myokymia"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02919",
    "question": "What is associated with Early-onset severe Hermansky-Pudlak syndrome with hearing loss, due to AP3D1 deficiency?",
    "seeds": [
      "Early-onset severe Hermansky-Pudlak syndrome with hearing loss, due to AP3D1 deficiency"
    ],
    "gold_answer": "AP3D1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_test_02920",
    "question": "What is associated with Asymmetrical insertion of the midpiece into the head?",
    "seeds": [
      "Asymmetrical insertion of the midpiece into the head"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02921",
    "question": "What is associated with Round epiphyses of the upper limbs?",
    "seeds": [
      "Round epiphyses of the upper limbs"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02922",
    "question": "What is associated with Ectopic ossification in muscle tissue?",
    "seeds": [
      "Ectopic ossification in muscle tissue"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02923",
    "question": "What is associated with Specific anosmia?",
    "seeds": [
      "Specific anosmia"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02924",
    "question": "What is associated with Acrania?",
    "seeds": [
      "Acrania"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02925",
    "question": "What is associated with Fossa navicularis urethral stricture?",
    "seeds": [
      "Fossa navicularis urethral stricture"
    ],
    "gold_answer": "Urethral obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02926",
    "question": "What phenotype is associated with Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction?",
    "seeds": [
      "Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction"
    ],
    "gold_answer": "Barrett esophagus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02927",
    "question": "What is associated with Aplasia/Hypoplasia of the proximal phalanx of the hallux?",
    "seeds": [
      "Aplasia/Hypoplasia of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Absent toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02928",
    "question": "What is associated with Wrist flexion contracture?",
    "seeds": [
      "Wrist flexion contracture"
    ],
    "gold_answer": "Abnormality of upper limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02929",
    "question": "What is associated with Contracture of the distal interphalangeal joint of the 3rd toe?",
    "seeds": [
      "Contracture of the distal interphalangeal joint of the 3rd toe"
    ],
    "gold_answer": "Flexion contracture of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02930",
    "question": "What is associated with Abnormal chylomicron concentration?",
    "seeds": [
      "Abnormal chylomicron concentration"
    ],
    "gold_answer": "Abnormal circulating cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02931",
    "question": "What phenotype is associated with Central core disease?",
    "seeds": [
      "Central core disease"
    ],
    "gold_answer": "Delayed ability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02932",
    "question": "What is associated with Anti-GD1b IgM antibody positivity?",
    "seeds": [
      "Anti-GD1b IgM antibody positivity"
    ],
    "gold_answer": "Anti-ganglioside antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02933",
    "question": "What phenotype is associated with Gómez-López-Hernández syndrome?",
    "seeds": [
      "Gómez-López-Hernández syndrome"
    ],
    "gold_answer": "Hydrocephalus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02934",
    "question": "What is associated with Progressive myoclonic epilepsy type 7?",
    "seeds": [
      "Progressive myoclonic epilepsy type 7"
    ],
    "gold_answer": "KCNC1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_test_02935",
    "question": "What is associated with Myopathy with extrapyramidal signs?",
    "seeds": [
      "Myopathy with extrapyramidal signs"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02936",
    "question": "What is associated with SPONDYLOLISTHESIS?",
    "seeds": [
      "SPONDYLOLISTHESIS"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02937",
    "question": "What is associated with MMEP syndrome?",
    "seeds": [
      "MMEP syndrome"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02938",
    "question": "What is associated with Neurofaciodigitorenal syndrome?",
    "seeds": [
      "Neurofaciodigitorenal syndrome"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02939",
    "question": "What is associated with Anti-p53 antibody positivity?",
    "seeds": [
      "Anti-p53 antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02940",
    "question": "What is associated with Abnormal corneal stroma morphology?",
    "seeds": [
      "Abnormal corneal stroma morphology"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02941",
    "question": "What is associated with Anorchism?",
    "seeds": [
      "Anorchism"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02942",
    "question": "What is associated with Coronal cleft vertebrae?",
    "seeds": [
      "Coronal cleft vertebrae"
    ],
    "gold_answer": "Vertebral clefting",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02943",
    "question": "What is associated with Neuromuscular dysphagia?",
    "seeds": [
      "Neuromuscular dysphagia"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02944",
    "question": "What is associated with Deafness, autosomal recessive 65?",
    "seeds": [
      "Deafness, autosomal recessive 65"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02945",
    "question": "What is associated with Undetectable pattern electroretinogram?",
    "seeds": [
      "Undetectable pattern electroretinogram"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02946",
    "question": "What is associated with Submucous cleft hard palate?",
    "seeds": [
      "Submucous cleft hard palate"
    ],
    "gold_answer": "Cleft hard palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02947",
    "question": "What is associated with Oculopharyngeal muscular dystrophy?",
    "seeds": [
      "Oculopharyngeal muscular dystrophy"
    ],
    "gold_answer": "Cranial nerve paralysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02948",
    "question": "What is associated with Subcapsular cataract?",
    "seeds": [
      "Subcapsular cataract"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02949",
    "question": "What is associated with Rhonchi?",
    "seeds": [
      "Rhonchi"
    ],
    "gold_answer": "Abnormal breath sound",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02950",
    "question": "What is associated with Patchy sclerosis of 4th finger phalanx?",
    "seeds": [
      "Patchy sclerosis of 4th finger phalanx"
    ],
    "gold_answer": "Patchy osteosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02951",
    "question": "What is associated with Immunodeficiency?",
    "seeds": [
      "Immunodeficiency"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02952",
    "question": "What is associated with Abnormality of the musculoskeletal system?",
    "seeds": [
      "Abnormality of the musculoskeletal system"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02953",
    "question": "What is associated with Prolonged whole-blood clotting time?",
    "seeds": [
      "Prolonged whole-blood clotting time"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02954",
    "question": "What is associated with Subluxation of the small joints of the hand?",
    "seeds": [
      "Subluxation of the small joints of the hand"
    ],
    "gold_answer": "Abnormal phalangeal joint morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02955",
    "question": "What is associated with Abnormal CD25 upregulation upon TCR activation?",
    "seeds": [
      "Abnormal CD25 upregulation upon TCR activation"
    ],
    "gold_answer": "Abnormal T cell physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02956",
    "question": "What is associated with Focal impaired awareness emotional seizure with paranoia?",
    "seeds": [
      "Focal impaired awareness emotional seizure with paranoia"
    ],
    "gold_answer": "Focal impaired awareness seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02957",
    "question": "What is associated with Osteopetrosis, autosomal recessive 9?",
    "seeds": [
      "Osteopetrosis, autosomal recessive 9"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02958",
    "question": "What is associated with Upper airway obstruction?",
    "seeds": [
      "Upper airway obstruction"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02959",
    "question": "What is associated with Polygenic inheritance?",
    "seeds": [
      "Polygenic inheritance"
    ],
    "gold_answer": "Mode of inheritance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02960",
    "question": "What is associated with EEG with photoparoxysmal response grade III?",
    "seeds": [
      "EEG with photoparoxysmal response grade III"
    ],
    "gold_answer": "EEG with photoparoxysmal response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02961",
    "question": "What is associated with Cupped ear?",
    "seeds": [
      "Cupped ear"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02962",
    "question": "What is associated with Anti-DREBRIN antibody positivity?",
    "seeds": [
      "Anti-DREBRIN antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02963",
    "question": "What is associated with Pancreatic hypoplasia?",
    "seeds": [
      "Pancreatic hypoplasia"
    ],
    "gold_answer": "Abnormal pancreas morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02964",
    "question": "What is associated with Lipoyltransferase 1 deficiency?",
    "seeds": [
      "Lipoyltransferase 1 deficiency"
    ],
    "gold_answer": "Appendicular spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02965",
    "question": "What phenotype is associated with Achondrogenesis type 1A?",
    "seeds": [
      "Achondrogenesis type 1A"
    ],
    "gold_answer": "Abdominal distention",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02966",
    "question": "What phenotype is associated with Periventricular nodular heterotopia 7?",
    "seeds": [
      "Periventricular nodular heterotopia 7"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02967",
    "question": "What is associated with Abnormal vestibular saccule morphology?",
    "seeds": [
      "Abnormal vestibular saccule morphology"
    ],
    "gold_answer": "Abnormal inner ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02968",
    "question": "What is associated with Axonal loss?",
    "seeds": [
      "Axonal loss"
    ],
    "gold_answer": "Peripheral axonal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02969",
    "question": "What is associated with Focal aware vocal automatism seizure?",
    "seeds": [
      "Focal aware vocal automatism seizure"
    ],
    "gold_answer": "Focal automatism seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02970",
    "question": "What is associated with Immunodeficiency 21?",
    "seeds": [
      "Immunodeficiency 21"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02971",
    "question": "What phenotype is associated with Allergic bronchopulmonary aspergillosis?",
    "seeds": [
      "Allergic bronchopulmonary aspergillosis"
    ],
    "gold_answer": "Emphysema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02972",
    "question": "What is associated with Mercury exposure?",
    "seeds": [
      "Mercury exposure"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02973",
    "question": "What is associated with Astley-Kendall dysplasia?",
    "seeds": [
      "Astley-Kendall dysplasia"
    ],
    "gold_answer": "Abnormal epiphyseal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02974",
    "question": "What is associated with Abnormal fallopian tube morphology?",
    "seeds": [
      "Abnormal fallopian tube morphology"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02975",
    "question": "What is associated with Leukocyte migration defect?",
    "seeds": [
      "Leukocyte migration defect"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02976",
    "question": "What is associated with Ochronosis?",
    "seeds": [
      "Ochronosis"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02977",
    "question": "What is associated with Difficulty adjusting from dark to light?",
    "seeds": [
      "Difficulty adjusting from dark to light"
    ],
    "gold_answer": "Difficulty adjusting to changes in luminance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02978",
    "question": "What is associated with Incomplete partition of the cochlea type II?",
    "seeds": [
      "Incomplete partition of the cochlea type II"
    ],
    "gold_answer": "Cochlear malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02979",
    "question": "What is associated with Midface capillary hemangioma?",
    "seeds": [
      "Midface capillary hemangioma"
    ],
    "gold_answer": "Hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02980",
    "question": "What is associated with Iliac horns?",
    "seeds": [
      "Iliac horns"
    ],
    "gold_answer": "Abnormal hip bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02981",
    "question": "What is associated with GALACTORRHEA?",
    "seeds": [
      "GALACTORRHEA"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02982",
    "question": "What is associated with Drowsiness?",
    "seeds": [
      "Drowsiness"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02983",
    "question": "What phenotype is associated with Spastic paraplegia, optic atrophy, and dementia?",
    "seeds": [
      "Spastic paraplegia, optic atrophy, and dementia"
    ],
    "gold_answer": "Optic atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_test_02984",
    "question": "What is associated with Ehlers-danlos syndrome, Hypermobility type?",
    "seeds": [
      "Ehlers-danlos syndrome, Hypermobility type"
    ],
    "gold_answer": "Arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02985",
    "question": "What is associated with Florid cemento-osseous dysplasia?",
    "seeds": [
      "Florid cemento-osseous dysplasia"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02986",
    "question": "What is associated with Spinal muscular atrophy, lower extremity-predominant, 2B, autosomal dominant?",
    "seeds": [
      "Spinal muscular atrophy, lower extremity-predominant, 2B, autosomal dominant"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02987",
    "question": "What is associated with Macular hole?",
    "seeds": [
      "Macular hole"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02988",
    "question": "What is associated with Increased anterioposterior diameter of thorax?",
    "seeds": [
      "Increased anterioposterior diameter of thorax"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02989",
    "question": "What is associated with Piebaldism?",
    "seeds": [
      "Piebaldism"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02990",
    "question": "What is associated with Bilateral renal atrophy?",
    "seeds": [
      "Bilateral renal atrophy"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02991",
    "question": "What is associated with Abnormality of nasal musculature?",
    "seeds": [
      "Abnormality of nasal musculature"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02992",
    "question": "What is associated with Radiation into right arm?",
    "seeds": [
      "Radiation into right arm"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02993",
    "question": "What is associated with Abnormal level of platelet-activating factor?",
    "seeds": [
      "Abnormal level of platelet-activating factor"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02994",
    "question": "What is associated with Lens subluxation?",
    "seeds": [
      "Lens subluxation"
    ],
    "gold_answer": "Ectopia lentis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02995",
    "question": "What is associated with Fetal lower urinary tract obstruction?",
    "seeds": [
      "Fetal lower urinary tract obstruction"
    ],
    "gold_answer": "Abnormal fetal genitourinary system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02996",
    "question": "What is associated with Colorectal cancer, susceptibility to, 12?",
    "seeds": [
      "Colorectal cancer, susceptibility to, 12"
    ],
    "gold_answer": "Large intestinal polyposis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02997",
    "question": "What is associated with Irregular epiphysis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Irregular epiphysis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the distal phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02998",
    "question": "What is associated with Roifman syndrome?",
    "seeds": [
      "Roifman syndrome"
    ],
    "gold_answer": "Temporal cortical atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_test_02999",
    "question": "What is associated with Copper beaten skull?",
    "seeds": [
      "Copper beaten skull"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  }
]