[
  {
    "query_id": "orph_train_00000",
    "question": "What is associated with Triggered by stress?",
    "seeds": [
      "Triggered by stress"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00001",
    "question": "What is associated with Omodysplasia 1?",
    "seeds": [
      "Omodysplasia 1"
    ],
    "gold_answer": "Abnormal abdominal wall morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00002",
    "question": "What phenotype is associated with Wildervanck syndrome?",
    "seeds": [
      "Wildervanck syndrome"
    ],
    "gold_answer": "Meningocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00003",
    "question": "What is associated with Tooth abscess?",
    "seeds": [
      "Tooth abscess"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00004",
    "question": "What is associated with Talipes equinovalgus?",
    "seeds": [
      "Talipes equinovalgus"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00005",
    "question": "What is associated with Esophagitis?",
    "seeds": [
      "Esophagitis"
    ],
    "gold_answer": "Gastrointestinal inflammation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00006",
    "question": "What is associated with Coronary cameral fistula to right ventricle?",
    "seeds": [
      "Coronary cameral fistula to right ventricle"
    ],
    "gold_answer": "Abnormal coronary artery course",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00007",
    "question": "What is associated with Digenic inheritance?",
    "seeds": [
      "Digenic inheritance"
    ],
    "gold_answer": "Non-Mendelian inheritance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00008",
    "question": "What is associated with Leiomyoma of vulva and esophagus?",
    "seeds": [
      "Leiomyoma of vulva and esophagus"
    ],
    "gold_answer": "Increased size of the clitoris",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00009",
    "question": "What phenotype is associated with Neu-Laxova syndrome 2?",
    "seeds": [
      "Neu-Laxova syndrome 2"
    ],
    "gold_answer": "Cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00010",
    "question": "What is associated with Enlarged epiphyses of the toes?",
    "seeds": [
      "Enlarged epiphyses of the toes"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00011",
    "question": "What is associated with Testicular microlithiasis?",
    "seeds": [
      "Testicular microlithiasis"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00012",
    "question": "What is associated with Patchy atrophy of the retinal pigment epithelium?",
    "seeds": [
      "Patchy atrophy of the retinal pigment epithelium"
    ],
    "gold_answer": "Retinal pigment epithelial atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00013",
    "question": "What is associated with Autosomal recessive intermediate Charcot-Marie-Tooth disease type B?",
    "seeds": [
      "Autosomal recessive intermediate Charcot-Marie-Tooth disease type B"
    ],
    "gold_answer": "KARS1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00014",
    "question": "What is associated with Reduced circulating 6-pyruvoyltetrahydropterin synthase activity?",
    "seeds": [
      "Reduced circulating 6-pyruvoyltetrahydropterin synthase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00015",
    "question": "What is associated with Spicular pigmentation of the retina?",
    "seeds": [
      "Spicular pigmentation of the retina"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00016",
    "question": "What is associated with Positive direct antiglobulin test?",
    "seeds": [
      "Positive direct antiglobulin test"
    ],
    "gold_answer": "Anti-erythrocyte autoantibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00017",
    "question": "What is associated with Scapuloperoneal weakness?",
    "seeds": [
      "Scapuloperoneal weakness"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00018",
    "question": "What phenotype is associated with Pontiac fever?",
    "seeds": [
      "Pontiac fever"
    ],
    "gold_answer": "Fever",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00019",
    "question": "What is associated with Episodic pain syndrome, familial, 3?",
    "seeds": [
      "Episodic pain syndrome, familial, 3"
    ],
    "gold_answer": "Abnormality of the autonomic nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00020",
    "question": "What is associated with Fetal distress?",
    "seeds": [
      "Fetal distress"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00021",
    "question": "What phenotype is associated with Spastic paraplegia 77, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 77, autosomal recessive"
    ],
    "gold_answer": "Upper limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00022",
    "question": "What is associated with Hypertrichosis?",
    "seeds": [
      "Hypertrichosis"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00023",
    "question": "What is associated with Aplasia/Hypoplasia involving bones of the feet?",
    "seeds": [
      "Aplasia/Hypoplasia involving bones of the feet"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00024",
    "question": "What is associated with Kleine-Levin hibernation syndrome?",
    "seeds": [
      "Kleine-Levin hibernation syndrome"
    ],
    "gold_answer": "Abnormal consumption behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00025",
    "question": "What is associated with Zimmermann-Laband syndrome 1?",
    "seeds": [
      "Zimmermann-Laband syndrome 1"
    ],
    "gold_answer": "Abnormality of mouth shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00026",
    "question": "What is associated with Nephroblastoma?",
    "seeds": [
      "Nephroblastoma"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00027",
    "question": "What is associated with Propionyl-CoA carboxylase deficiency?",
    "seeds": [
      "Propionyl-CoA carboxylase deficiency"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00028",
    "question": "What is associated with Severe combined immunodeficiency due to CTPS1 deficiency?",
    "seeds": [
      "Severe combined immunodeficiency due to CTPS1 deficiency"
    ],
    "gold_answer": "CTPS1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_00029",
    "question": "What is associated with Syringomas, multiple?",
    "seeds": [
      "Syringomas, multiple"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00030",
    "question": "What is associated with Cortical peritubular capillary lumen organized thrombi?",
    "seeds": [
      "Cortical peritubular capillary lumen organized thrombi"
    ],
    "gold_answer": "Abnormal cortical peritubular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00031",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 78?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 78"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00032",
    "question": "What is associated with Cervical squamous cell papilloma?",
    "seeds": [
      "Cervical squamous cell papilloma"
    ],
    "gold_answer": "Abnormality of the uterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00033",
    "question": "What is associated with Elevated circulating carcinoma antigen 125 concentration?",
    "seeds": [
      "Elevated circulating carcinoma antigen 125 concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00034",
    "question": "What is associated with Retinal pigment epithelial atrophy?",
    "seeds": [
      "Retinal pigment epithelial atrophy"
    ],
    "gold_answer": "Retinal atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00035",
    "question": "What is associated with X-linked intellectual disability-cerebellar hypoplasia syndrome?",
    "seeds": [
      "X-linked intellectual disability-cerebellar hypoplasia syndrome"
    ],
    "gold_answer": "Abnormal cerebral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00036",
    "question": "What is associated with Abnormal neuron branching?",
    "seeds": [
      "Abnormal neuron branching"
    ],
    "gold_answer": "Abnormal neuron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00037",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, axonal, type 2II?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2II"
    ],
    "gold_answer": "Areflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00038",
    "question": "What is associated with Vestibular nystagmus?",
    "seeds": [
      "Vestibular nystagmus"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00039",
    "question": "What is associated with Profound?",
    "seeds": [
      "Profound"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00040",
    "question": "What phenotype is associated with Long QT syndrome 11?",
    "seeds": [
      "Long QT syndrome 11"
    ],
    "gold_answer": "Prolonged QTc interval",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00041",
    "question": "What is associated with Lichen planus, familial?",
    "seeds": [
      "Lichen planus, familial"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00042",
    "question": "What is associated with Pulmonary pseudocavity?",
    "seeds": [
      "Pulmonary pseudocavity"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00043",
    "question": "What is associated with Spermatogenic failure 85?",
    "seeds": [
      "Spermatogenic failure 85"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00044",
    "question": "What is associated with Familial bicuspid aortic valve?",
    "seeds": [
      "Familial bicuspid aortic valve"
    ],
    "gold_answer": "Cardiac valve calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00045",
    "question": "What is associated with Ameliorated by acetazolamide?",
    "seeds": [
      "Ameliorated by acetazolamide"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00046",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia with joint laxity, Beighton type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia with joint laxity, Beighton type"
    ],
    "gold_answer": "B3GALT6",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00047",
    "question": "What is associated with Reduced blood 5-methyltetrahydrofolate level?",
    "seeds": [
      "Reduced blood 5-methyltetrahydrofolate level"
    ],
    "gold_answer": "Abnormal blood 5-methyltetrahydrofolate level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00048",
    "question": "What is associated with Absent epiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Absent epiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00049",
    "question": "What phenotype is associated with Immunodeficiency by defective expression of MHC class II?",
    "seeds": [
      "Immunodeficiency by defective expression of MHC class II"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00050",
    "question": "What is associated with Central retinal vessel vascular tortuosity?",
    "seeds": [
      "Central retinal vessel vascular tortuosity"
    ],
    "gold_answer": "Arterial tortuosity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00051",
    "question": "What is associated with Short stature and facioauriculothoracic malformations?",
    "seeds": [
      "Short stature and facioauriculothoracic malformations"
    ],
    "gold_answer": "Supernumerary ribs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00052",
    "question": "What is associated with 3MC syndrome 1?",
    "seeds": [
      "3MC syndrome 1"
    ],
    "gold_answer": "Hypertrichosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00053",
    "question": "What is associated with Aggravated by activity?",
    "seeds": [
      "Aggravated by activity"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00054",
    "question": "What is associated with Sclerosis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Sclerosis of finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00055",
    "question": "What is associated with Depressed glabella?",
    "seeds": [
      "Depressed glabella"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00056",
    "question": "What is associated with Decreased circulating C1-esterase inhibitor concentration?",
    "seeds": [
      "Decreased circulating C1-esterase inhibitor concentration"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00057",
    "question": "What is associated with Atrial fibrillation, familial, 11?",
    "seeds": [
      "Atrial fibrillation, familial, 11"
    ],
    "gold_answer": "Abnormal left ventricular ejection fraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00058",
    "question": "What is associated with Congenital myopathy 25?",
    "seeds": [
      "Congenital myopathy 25"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00059",
    "question": "What is associated with Recurrent respiratory papillomatosis?",
    "seeds": [
      "Recurrent respiratory papillomatosis"
    ],
    "gold_answer": "Pneumonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00060",
    "question": "What is associated with Aneurysm-osteoarthritis syndrome?",
    "seeds": [
      "Aneurysm-osteoarthritis syndrome"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00061",
    "question": "What is associated with Ragged-red muscle fibers?",
    "seeds": [
      "Ragged-red muscle fibers"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00062",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, axonal, type 2A1?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2A1"
    ],
    "gold_answer": "Pes cavus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00063",
    "question": "What is associated with Lysosomal acid lipase deficiency?",
    "seeds": [
      "Lysosomal acid lipase deficiency"
    ],
    "gold_answer": "Abnormal hepatobiliary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00064",
    "question": "What is associated with Progressive night blindness?",
    "seeds": [
      "Progressive night blindness"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00065",
    "question": "What phenotype is associated with Ellis-Van creveld syndrome?",
    "seeds": [
      "Ellis-Van creveld syndrome"
    ],
    "gold_answer": "Short long bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00066",
    "question": "What is associated with Elevated circulating glutaric acid concentration?",
    "seeds": [
      "Elevated circulating glutaric acid concentration"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00067",
    "question": "What is associated with Cytologic atypia in mantle cells?",
    "seeds": [
      "Cytologic atypia in mantle cells"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00068",
    "question": "What is associated with Circumscribed?",
    "seeds": [
      "Circumscribed"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00069",
    "question": "What is associated with Elevated circulating branched chain amino acid concentration?",
    "seeds": [
      "Elevated circulating branched chain amino acid concentration"
    ],
    "gold_answer": "Abnormal circulating branched chain amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00070",
    "question": "What phenotype is associated with Coffin-siris syndrome 6?",
    "seeds": [
      "Coffin-siris syndrome 6"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00071",
    "question": "What is associated with Hypoxanthine guanine phosphoribosyltransferase partial deficiency?",
    "seeds": [
      "Hypoxanthine guanine phosphoribosyltransferase partial deficiency"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00072",
    "question": "What is associated with Typified by somatic mosaicism?",
    "seeds": [
      "Typified by somatic mosaicism"
    ],
    "gold_answer": "Inheritance qualifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00073",
    "question": "What phenotype is associated with Trigonocephaly 1?",
    "seeds": [
      "Trigonocephaly 1"
    ],
    "gold_answer": "Synophrys",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00074",
    "question": "What is associated with Proteasome-associated autoinflammatory syndrome?",
    "seeds": [
      "Proteasome-associated autoinflammatory syndrome"
    ],
    "gold_answer": "PSMB8",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00075",
    "question": "What is associated with Increased mannosylation of N-linked protein glycosylation?",
    "seeds": [
      "Increased mannosylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal mannosylation of N-linked protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00076",
    "question": "What phenotype is associated with Meckel syndrome 13?",
    "seeds": [
      "Meckel syndrome 13"
    ],
    "gold_answer": "Occipital encephalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00077",
    "question": "What is associated with L-2-hydroxyglutaric acidemia?",
    "seeds": [
      "L-2-hydroxyglutaric acidemia"
    ],
    "gold_answer": "Abnormal circulating dicarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00078",
    "question": "What is associated with Intellectual developmental disorder, X-linked syndromic 37?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic 37"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00079",
    "question": "What is associated with Abnormal cry?",
    "seeds": [
      "Abnormal cry"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00080",
    "question": "What is associated with Bardet-Biedl syndrome 17?",
    "seeds": [
      "Bardet-Biedl syndrome 17"
    ],
    "gold_answer": "Abnormal urine output",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00081",
    "question": "What is associated with Angioid streaks?",
    "seeds": [
      "Angioid streaks"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00082",
    "question": "What is associated with Hyposegmentation of neutrophil nuclei?",
    "seeds": [
      "Hyposegmentation of neutrophil nuclei"
    ],
    "gold_answer": "Abnormality of neutrophils",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00083",
    "question": "What is associated with Triangular shaped distal phalanges of the hand?",
    "seeds": [
      "Triangular shaped distal phalanges of the hand"
    ],
    "gold_answer": "Triangular shaped phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00084",
    "question": "What is associated with Shellfish allergy?",
    "seeds": [
      "Shellfish allergy"
    ],
    "gold_answer": "Allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00085",
    "question": "What is associated with Membranoproliferative glomerulonephritis?",
    "seeds": [
      "Membranoproliferative glomerulonephritis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00086",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 76?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 76"
    ],
    "gold_answer": "Precocious puberty in females",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00087",
    "question": "What phenotype is associated with Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2?",
    "seeds": [
      "Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2"
    ],
    "gold_answer": "Deeply set eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00088",
    "question": "What is associated with Impaired cortisol response to corticotropin releasing hormone stimulation test?",
    "seeds": [
      "Impaired cortisol response to corticotropin releasing hormone stimulation test"
    ],
    "gold_answer": "Abnormal endocrine physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00089",
    "question": "What is associated with Unilateral facial palsy?",
    "seeds": [
      "Unilateral facial palsy"
    ],
    "gold_answer": "Facial palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00090",
    "question": "What is associated with Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies"
    ],
    "gold_answer": "Abnormality of salivation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00091",
    "question": "What is associated with Aplasia/Hypoplasia involving the corticospinal tracts?",
    "seeds": [
      "Aplasia/Hypoplasia involving the corticospinal tracts"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00092",
    "question": "What is associated with Increased memory T cell proportion?",
    "seeds": [
      "Increased memory T cell proportion"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00093",
    "question": "What is associated with Calvarial skull defect?",
    "seeds": [
      "Calvarial skull defect"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00094",
    "question": "What is associated with Developmental delay-overweight-facial dysmorphism-behavioral abnormalities syndrome?",
    "seeds": [
      "Developmental delay-overweight-facial dysmorphism-behavioral abnormalities syndrome"
    ],
    "gold_answer": "SRRM2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00095",
    "question": "What is associated with Basal ganglia calcification, idiopathic, 6?",
    "seeds": [
      "Basal ganglia calcification, idiopathic, 6"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00096",
    "question": "What is associated with Abnormal ureter physiology?",
    "seeds": [
      "Abnormal ureter physiology"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00097",
    "question": "What is associated with Heat intolerance?",
    "seeds": [
      "Heat intolerance"
    ],
    "gold_answer": "Abnormality of temperature regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00098",
    "question": "What is associated with Irregular ossification of the radial metaphysis?",
    "seeds": [
      "Irregular ossification of the radial metaphysis"
    ],
    "gold_answer": "Abnormal radial metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00099",
    "question": "What is associated with Starch intolerance?",
    "seeds": [
      "Starch intolerance"
    ],
    "gold_answer": "Malabsorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00100",
    "question": "What is associated with Bladder pain?",
    "seeds": [
      "Bladder pain"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00101",
    "question": "What phenotype is associated with Hermansky-Pudlak syndrome 1?",
    "seeds": [
      "Hermansky-Pudlak syndrome 1"
    ],
    "gold_answer": "Hypopigmentation of hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00102",
    "question": "What is associated with Neonatal hypoglycemia?",
    "seeds": [
      "Neonatal hypoglycemia"
    ],
    "gold_answer": "Hypoglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00103",
    "question": "What is associated with Flail chest?",
    "seeds": [
      "Flail chest"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00104",
    "question": "What is associated with Retinitis pigmentosa 7?",
    "seeds": [
      "Retinitis pigmentosa 7"
    ],
    "gold_answer": "Abnormal retinal pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00105",
    "question": "What is associated with Descending aortic dissection?",
    "seeds": [
      "Descending aortic dissection"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00106",
    "question": "What is associated with Photosensitive tonic-clonic seizure?",
    "seeds": [
      "Photosensitive tonic-clonic seizure"
    ],
    "gold_answer": "Bilateral tonic-clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00107",
    "question": "What is associated with Nummular eczema?",
    "seeds": [
      "Nummular eczema"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00108",
    "question": "What is associated with Folate-unresponsive megaloblastic anemia?",
    "seeds": [
      "Folate-unresponsive megaloblastic anemia"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00109",
    "question": "What is associated with Aplasia of the phalanges of the hand?",
    "seeds": [
      "Aplasia of the phalanges of the hand"
    ],
    "gold_answer": "Aplasia involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00110",
    "question": "What is associated with Microcephaly 27, primary, autosomal dominant?",
    "seeds": [
      "Microcephaly 27, primary, autosomal dominant"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00111",
    "question": "What is associated with Abnormal second toe morphology?",
    "seeds": [
      "Abnormal second toe morphology"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00112",
    "question": "What is associated with Cone-shaped epiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Cone-shaped epiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00113",
    "question": "What is associated with Abnormality of dorsoventral patterning of the limbs?",
    "seeds": [
      "Abnormality of dorsoventral patterning of the limbs"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00114",
    "question": "What is associated with Nail disorder, nonsyndromic congenital, 7?",
    "seeds": [
      "Nail disorder, nonsyndromic congenital, 7"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00115",
    "question": "What is associated with Nodular melanoma?",
    "seeds": [
      "Nodular melanoma"
    ],
    "gold_answer": "Melanoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00116",
    "question": "What is associated with Orofaciodigital syndrome type 5?",
    "seeds": [
      "Orofaciodigital syndrome type 5"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00117",
    "question": "What is associated with Dementia?",
    "seeds": [
      "Dementia"
    ],
    "gold_answer": "Cognitive impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00118",
    "question": "What is associated with Cardiac polyglucosan accumulation?",
    "seeds": [
      "Cardiac polyglucosan accumulation"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00119",
    "question": "What is associated with Short 4th toe?",
    "seeds": [
      "Short 4th toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00120",
    "question": "What is associated with Chondritis?",
    "seeds": [
      "Chondritis"
    ],
    "gold_answer": "Abnormal cartilage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00121",
    "question": "What is associated with Spermiation failure?",
    "seeds": [
      "Spermiation failure"
    ],
    "gold_answer": "Non-obstructive azoospermia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00122",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 63?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 63"
    ],
    "gold_answer": "Abnormal periventricular white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00123",
    "question": "What is associated with Pouchitis?",
    "seeds": [
      "Pouchitis"
    ],
    "gold_answer": "Abnormal large intestine physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00124",
    "question": "What is associated with Abnormal basal ganglia MRI signal intensity?",
    "seeds": [
      "Abnormal basal ganglia MRI signal intensity"
    ],
    "gold_answer": "Abnormal basal ganglia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00125",
    "question": "What is associated with Increased anti-insect IgE antibody level?",
    "seeds": [
      "Increased anti-insect IgE antibody level"
    ],
    "gold_answer": "Abnormal B cell physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00126",
    "question": "What phenotype is associated with Intrauterine growth retardation with increased mitomycin C sensitivity?",
    "seeds": [
      "Intrauterine growth retardation with increased mitomycin C sensitivity"
    ],
    "gold_answer": "Abnormality of chromosome stability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00127",
    "question": "What is associated with Intralamellar aortic medial fibrosis?",
    "seeds": [
      "Intralamellar aortic medial fibrosis"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00128",
    "question": "What is associated with Supraventricular arrhythmia?",
    "seeds": [
      "Supraventricular arrhythmia"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00129",
    "question": "What is associated with Elevated maternal circulating alpha-fetoprotein concentration?",
    "seeds": [
      "Elevated maternal circulating alpha-fetoprotein concentration"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00130",
    "question": "What is associated with Cavitation of the basal ganglia?",
    "seeds": [
      "Cavitation of the basal ganglia"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00131",
    "question": "What is associated with Reduced tissue neuraminidase activity?",
    "seeds": [
      "Reduced tissue neuraminidase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00132",
    "question": "What is associated with Increased CSF alpha-aminobutyrate concentration?",
    "seeds": [
      "Increased CSF alpha-aminobutyrate concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00133",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, axonal, type 2P?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2P"
    ],
    "gold_answer": "Axonal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00134",
    "question": "What is associated with Gliosarcoma?",
    "seeds": [
      "Gliosarcoma"
    ],
    "gold_answer": "TACC3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_00135",
    "question": "What phenotype is associated with Retinitis pigmentosa 93?",
    "seeds": [
      "Retinitis pigmentosa 93"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00136",
    "question": "What is associated with Dacryocytosis?",
    "seeds": [
      "Dacryocytosis"
    ],
    "gold_answer": "Poikilocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00137",
    "question": "What is associated with Coronoid fracture?",
    "seeds": [
      "Coronoid fracture"
    ],
    "gold_answer": "Fractured forearm bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00138",
    "question": "What is associated with Gray matter heterotopia?",
    "seeds": [
      "Gray matter heterotopia"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00139",
    "question": "What is associated with Hopelessness?",
    "seeds": [
      "Hopelessness"
    ],
    "gold_answer": "Abnormal preoccupation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00140",
    "question": "What is associated with Hirschsprung disease-type D brachydactyly syndrome?",
    "seeds": [
      "Hirschsprung disease-type D brachydactyly syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00141",
    "question": "What is associated with Mitochondrial encephalopathy?",
    "seeds": [
      "Mitochondrial encephalopathy"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00142",
    "question": "What is associated with Autosomal recessive Alport syndrome?",
    "seeds": [
      "Autosomal recessive Alport syndrome"
    ],
    "gold_answer": "COL4A4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00143",
    "question": "What is associated with Self-limited epilepsy with centrotemporal spikes?",
    "seeds": [
      "Self-limited epilepsy with centrotemporal spikes"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00144",
    "question": "What is associated with Opportunistic bacterial infection?",
    "seeds": [
      "Opportunistic bacterial infection"
    ],
    "gold_answer": "Opportunistic infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00145",
    "question": "What is associated with Sinus venosus atrial septal defect?",
    "seeds": [
      "Sinus venosus atrial septal defect"
    ],
    "gold_answer": "Atrial septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00146",
    "question": "What is associated with Sclerosis of the carpal bones?",
    "seeds": [
      "Sclerosis of the carpal bones"
    ],
    "gold_answer": "Sclerosis of hand bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00147",
    "question": "What is associated with Pseudoepiphysis of the proximal phalanx of the thumb?",
    "seeds": [
      "Pseudoepiphysis of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00148",
    "question": "What is associated with Foot joint contracture?",
    "seeds": [
      "Foot joint contracture"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00149",
    "question": "What is associated with Prenatal flattened diaphragm?",
    "seeds": [
      "Prenatal flattened diaphragm"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00150",
    "question": "What is associated with Malaise?",
    "seeds": [
      "Malaise"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00151",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2LL?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2LL"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00152",
    "question": "What is associated with Liver rupture?",
    "seeds": [
      "Liver rupture"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00153",
    "question": "What is associated with Abnormality of the cell cycle?",
    "seeds": [
      "Abnormality of the cell cycle"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00154",
    "question": "What is associated with White hair?",
    "seeds": [
      "White hair"
    ],
    "gold_answer": "Generalized hypopigmentation of hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00155",
    "question": "What is associated with Interictal epileptiform activity?",
    "seeds": [
      "Interictal epileptiform activity"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00156",
    "question": "What is associated with Cock-walk gait?",
    "seeds": [
      "Cock-walk gait"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00157",
    "question": "What is associated with Decreased number of large peripheral myelinated nerve fibers?",
    "seeds": [
      "Decreased number of large peripheral myelinated nerve fibers"
    ],
    "gold_answer": "Decreased number of peripheral myelinated nerve fibers",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00158",
    "question": "What is associated with Anterior predominant thick cortex pachygyria?",
    "seeds": [
      "Anterior predominant thick cortex pachygyria"
    ],
    "gold_answer": "Thick pachygyria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00159",
    "question": "What is associated with Blepharophimosis-impaired intellectual development syndrome?",
    "seeds": [
      "Blepharophimosis-impaired intellectual development syndrome"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00160",
    "question": "What is associated with Abnormal cortical radial artery intima/media morphology?",
    "seeds": [
      "Abnormal cortical radial artery intima/media morphology"
    ],
    "gold_answer": "Abnormal intrarenal artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00161",
    "question": "What is associated with Recurrent pneumonia?",
    "seeds": [
      "Recurrent pneumonia"
    ],
    "gold_answer": "Pneumonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00162",
    "question": "What is associated with Chromosome Xq13 duplication syndrome?",
    "seeds": [
      "Chromosome Xq13 duplication syndrome"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00163",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 9?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 9"
    ],
    "gold_answer": "Dysphagia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00164",
    "question": "What is associated with Leukocyte adhesion deficiency type III?",
    "seeds": [
      "Leukocyte adhesion deficiency type III"
    ],
    "gold_answer": "FERMT3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_00165",
    "question": "What is associated with Alveolar ridge overgrowth?",
    "seeds": [
      "Alveolar ridge overgrowth"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00166",
    "question": "What is associated with Knuckle pads?",
    "seeds": [
      "Knuckle pads"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00167",
    "question": "What is associated with Focal impaired awareness cognitive seizure?",
    "seeds": [
      "Focal impaired awareness cognitive seizure"
    ],
    "gold_answer": "Focal impaired awareness non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00168",
    "question": "What is associated with Abnormal muscle fiber protein expression?",
    "seeds": [
      "Abnormal muscle fiber protein expression"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00169",
    "question": "What is associated with Vestibular saccular degeneration?",
    "seeds": [
      "Vestibular saccular degeneration"
    ],
    "gold_answer": "Abnormal morphology of the vestibule of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00170",
    "question": "What is associated with Progressive ptosis?",
    "seeds": [
      "Progressive ptosis"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00171",
    "question": "What is associated with Reduced prothrombin consumption?",
    "seeds": [
      "Reduced prothrombin consumption"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00172",
    "question": "What phenotype is associated with Dystonia 24?",
    "seeds": [
      "Dystonia 24"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00173",
    "question": "What is associated with Lowe syndrome?",
    "seeds": [
      "Lowe syndrome"
    ],
    "gold_answer": "Central nervous system cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00174",
    "question": "What is associated with History of recent intermittent breastfeeding?",
    "seeds": [
      "History of recent intermittent breastfeeding"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00175",
    "question": "What is associated with Abdominal wall muscle weakness?",
    "seeds": [
      "Abdominal wall muscle weakness"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00176",
    "question": "What is associated with Elevated urinary creatine level?",
    "seeds": [
      "Elevated urinary creatine level"
    ],
    "gold_answer": "Abnormal urinary organic compound level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00177",
    "question": "What is associated with Uncombable hair syndrome 2?",
    "seeds": [
      "Uncombable hair syndrome 2"
    ],
    "gold_answer": "Abnormal hairshaft morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00178",
    "question": "What is associated with Increased neuronal autofluorescent lipopigment?",
    "seeds": [
      "Increased neuronal autofluorescent lipopigment"
    ],
    "gold_answer": "Increased cerebral lipofuscin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00179",
    "question": "What is associated with Macular dystrophy, retinal, 3?",
    "seeds": [
      "Macular dystrophy, retinal, 3"
    ],
    "gold_answer": "Drusen",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00180",
    "question": "What is associated with Addictive substance use?",
    "seeds": [
      "Addictive substance use"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00181",
    "question": "What is associated with Terminal hepatic lobular vascular occlusion?",
    "seeds": [
      "Terminal hepatic lobular vascular occlusion"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00182",
    "question": "What phenotype is associated with Follicular lymphoma, susceptibility to, 1?",
    "seeds": [
      "Follicular lymphoma, susceptibility to, 1"
    ],
    "gold_answer": "Follicular lymphoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00183",
    "question": "What is associated with 22q11.2 deletion syndrome?",
    "seeds": [
      "22q11.2 deletion syndrome"
    ],
    "gold_answer": "Abnormal lung development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00184",
    "question": "What phenotype is associated with Myopathy, myosin storage, autosomal dominant?",
    "seeds": [
      "Myopathy, myosin storage, autosomal dominant"
    ],
    "gold_answer": "Neck flexor weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00185",
    "question": "What is associated with Spinal and bulbar muscular atrophy, X-linked 1?",
    "seeds": [
      "Spinal and bulbar muscular atrophy, X-linked 1"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00186",
    "question": "What phenotype is associated with Thyroid hormone metabolism, abnormal?",
    "seeds": [
      "Thyroid hormone metabolism, abnormal"
    ],
    "gold_answer": "Delayed skeletal maturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00187",
    "question": "What is associated with Platystencephaly?",
    "seeds": [
      "Platystencephaly"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00188",
    "question": "What is associated with Oral synechia?",
    "seeds": [
      "Oral synechia"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00189",
    "question": "What is associated with Convulsions, familial infantile, with paroxysmal choreoathetosis?",
    "seeds": [
      "Convulsions, familial infantile, with paroxysmal choreoathetosis"
    ],
    "gold_answer": "Athetosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00190",
    "question": "What is associated with Epilepsy, nocturnal frontal lobe, type 1?",
    "seeds": [
      "Epilepsy, nocturnal frontal lobe, type 1"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00191",
    "question": "What is associated with Hemolytic anemia?",
    "seeds": [
      "Hemolytic anemia"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00192",
    "question": "What is associated with Cataract 13 with adult i phenotype?",
    "seeds": [
      "Cataract 13 with adult i phenotype"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00193",
    "question": "What is associated with Aberrant melanosome maturation?",
    "seeds": [
      "Aberrant melanosome maturation"
    ],
    "gold_answer": "Abnormality of dermal melanosomes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00194",
    "question": "What is associated with Smooth philtrum?",
    "seeds": [
      "Smooth philtrum"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00195",
    "question": "What is associated with Microform bilateral cleft lip?",
    "seeds": [
      "Microform bilateral cleft lip"
    ],
    "gold_answer": "Non-midline cleft of the upper lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00196",
    "question": "What is associated with Muscle fiber intracytoplasmic reducing inclusion bodies?",
    "seeds": [
      "Muscle fiber intracytoplasmic reducing inclusion bodies"
    ],
    "gold_answer": "Muscle fiber cytoplasmatic inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00197",
    "question": "What phenotype is associated with Ramon syndrome?",
    "seeds": [
      "Ramon syndrome"
    ],
    "gold_answer": "Hypertrichosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00198",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 108?",
    "seeds": [
      "Developmental and epileptic encephalopathy 108"
    ],
    "gold_answer": "Focal impaired awareness seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00199",
    "question": "What is associated with Genochondromatosis type 1?",
    "seeds": [
      "Genochondromatosis type 1"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00200",
    "question": "What phenotype is associated with Multiple enchondromatosis, Maffucci type?",
    "seeds": [
      "Multiple enchondromatosis, Maffucci type"
    ],
    "gold_answer": "Hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00201",
    "question": "What is associated with Abnormal HDL3a concentration?",
    "seeds": [
      "Abnormal HDL3a concentration"
    ],
    "gold_answer": "Abnormal HDL subfraction concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00202",
    "question": "What is associated with Otitis media?",
    "seeds": [
      "Otitis media"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00203",
    "question": "What phenotype is associated with Tibial hemimelia-polysyndactyly-triphalangeal thumb syndrome?",
    "seeds": [
      "Tibial hemimelia-polysyndactyly-triphalangeal thumb syndrome"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00204",
    "question": "What is associated with Small epiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Small epiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the middle phalanx of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00205",
    "question": "What is associated with Tubulonodular pericallosal lipoma?",
    "seeds": [
      "Tubulonodular pericallosal lipoma"
    ],
    "gold_answer": "Pericallosal lipoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00206",
    "question": "What is associated with Encephalopathy, progressive, early-onset, with brain atrophy and spasticity?",
    "seeds": [
      "Encephalopathy, progressive, early-onset, with brain atrophy and spasticity"
    ],
    "gold_answer": "EEG with generalized epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00207",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 6?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 6"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00208",
    "question": "What phenotype is associated with Amyotrophic lateral sclerosis 21?",
    "seeds": [
      "Amyotrophic lateral sclerosis 21"
    ],
    "gold_answer": "Bowing of the vocal cords",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00209",
    "question": "What is associated with Waardenburg syndrome type 2?",
    "seeds": [
      "Waardenburg syndrome type 2"
    ],
    "gold_answer": "SNAI2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00210",
    "question": "What is associated with Positive meconium methadone test?",
    "seeds": [
      "Positive meconium methadone test"
    ],
    "gold_answer": "Meconium xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00211",
    "question": "What is associated with Elevated urinary creatine/creatinine ratio?",
    "seeds": [
      "Elevated urinary creatine/creatinine ratio"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00212",
    "question": "What is associated with Patchy sclerosis of the distal phalanx of the 4th finger?",
    "seeds": [
      "Patchy sclerosis of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Patchy sclerosis of finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00213",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 6?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 6"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00214",
    "question": "What is associated with Fractured 1st metacarpal?",
    "seeds": [
      "Fractured 1st metacarpal"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00215",
    "question": "What is associated with Triceps hyporeflexia?",
    "seeds": [
      "Triceps hyporeflexia"
    ],
    "gold_answer": "Hyporeflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00216",
    "question": "What is associated with Pachyonychia congenita?",
    "seeds": [
      "Pachyonychia congenita"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00217",
    "question": "What is associated with Rightward direction of ventricular apex?",
    "seeds": [
      "Rightward direction of ventricular apex"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00218",
    "question": "What is associated with Nodular pattern on pulmonary HRCT?",
    "seeds": [
      "Nodular pattern on pulmonary HRCT"
    ],
    "gold_answer": "Abnormal pulmonary thoracic imaging finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00219",
    "question": "What phenotype is associated with Myopia 26, X-linked, female-limited?",
    "seeds": [
      "Myopia 26, X-linked, female-limited"
    ],
    "gold_answer": "High myopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00220",
    "question": "What is associated with Taurodontia?",
    "seeds": [
      "Taurodontia"
    ],
    "gold_answer": "Abnormality of molar",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00221",
    "question": "What phenotype is associated with ANDROSTENONE, ABILITY TO SMELL?",
    "seeds": [
      "ANDROSTENONE, ABILITY TO SMELL"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00222",
    "question": "What is associated with Absent Birbeck granules in Langerhans cells?",
    "seeds": [
      "Absent Birbeck granules in Langerhans cells"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00223",
    "question": "What is associated with Degeneration of anterior horn cells?",
    "seeds": [
      "Degeneration of anterior horn cells"
    ],
    "gold_answer": "Abnormal anterior horn cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00224",
    "question": "What is associated with Reduced response to gonadotropin-releasing hormone stimulation test?",
    "seeds": [
      "Reduced response to gonadotropin-releasing hormone stimulation test"
    ],
    "gold_answer": "Abnormal response to gonadotropin-releasing hormone stimulation test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00225",
    "question": "What is associated with Angiostrongyliasis?",
    "seeds": [
      "Angiostrongyliasis"
    ],
    "gold_answer": "Nausea and vomiting",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00226",
    "question": "What is associated with Myocardial immune cell infiltration?",
    "seeds": [
      "Myocardial immune cell infiltration"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00227",
    "question": "What is associated with Lack of peer relationships?",
    "seeds": [
      "Lack of peer relationships"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00228",
    "question": "What is associated with Impaired ocular abduction?",
    "seeds": [
      "Impaired ocular abduction"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00229",
    "question": "What is associated with Pinealoma?",
    "seeds": [
      "Pinealoma"
    ],
    "gold_answer": "Neuroepithelial neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00230",
    "question": "What phenotype is associated with Nephronophthisis 11?",
    "seeds": [
      "Nephronophthisis 11"
    ],
    "gold_answer": "Renal corticomedullary cysts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00231",
    "question": "What is associated with Dental root fusion?",
    "seeds": [
      "Dental root fusion"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00232",
    "question": "What is associated with Sclerosis of the 1st metatarsal?",
    "seeds": [
      "Sclerosis of the 1st metatarsal"
    ],
    "gold_answer": "Sclerosis of hallux phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00233",
    "question": "What is associated with Spermatogenic failure 11?",
    "seeds": [
      "Spermatogenic failure 11"
    ],
    "gold_answer": "Infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00234",
    "question": "What is associated with Cervical segmentation defect?",
    "seeds": [
      "Cervical segmentation defect"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00235",
    "question": "What is associated with Acrodermatitis enteropathica, Zinc-Deficiency type?",
    "seeds": [
      "Acrodermatitis enteropathica, Zinc-Deficiency type"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00236",
    "question": "What is associated with Perisylvian FDG hypermetabolism?",
    "seeds": [
      "Perisylvian FDG hypermetabolism"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00237",
    "question": "What phenotype is associated with Multicystic dysplastic kidney?",
    "seeds": [
      "Multicystic dysplastic kidney"
    ],
    "gold_answer": "Ureteral agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00238",
    "question": "What phenotype is associated with Kabuki syndrome 1?",
    "seeds": [
      "Kabuki syndrome 1"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00239",
    "question": "What is associated with NAILBEDS, PIGMENTATION OF?",
    "seeds": [
      "NAILBEDS, PIGMENTATION OF"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00240",
    "question": "What is associated with Lipodystrophy, familial partial, type 1?",
    "seeds": [
      "Lipodystrophy, familial partial, type 1"
    ],
    "gold_answer": "Diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00241",
    "question": "What is associated with Reticulocytopenia?",
    "seeds": [
      "Reticulocytopenia"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00242",
    "question": "What is associated with Vowel expressive impediment?",
    "seeds": [
      "Vowel expressive impediment"
    ],
    "gold_answer": "Speech articulation difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00243",
    "question": "What is associated with Ruffled acrosome?",
    "seeds": [
      "Ruffled acrosome"
    ],
    "gold_answer": "Abnormal sperm head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00244",
    "question": "What is associated with Contracture of the distal interphalangeal joint of the 2nd finger?",
    "seeds": [
      "Contracture of the distal interphalangeal joint of the 2nd finger"
    ],
    "gold_answer": "Flexion contracture of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00245",
    "question": "What is associated with Calf muscle pseudohypertrophy?",
    "seeds": [
      "Calf muscle pseudohypertrophy"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00246",
    "question": "What is associated with Triggered by viral infection?",
    "seeds": [
      "Triggered by viral infection"
    ],
    "gold_answer": "Triggered by infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00247",
    "question": "What is associated with Duplicated colon?",
    "seeds": [
      "Duplicated colon"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00248",
    "question": "What is associated with Juvenile type testicular granulosa cell tumor?",
    "seeds": [
      "Juvenile type testicular granulosa cell tumor"
    ],
    "gold_answer": "Gonadal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00249",
    "question": "What is associated with EEG with parietal sharp slow waves?",
    "seeds": [
      "EEG with parietal sharp slow waves"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00250",
    "question": "What is associated with Osteodysplasty, precocious, of danks, mayne, and kozlowski?",
    "seeds": [
      "Osteodysplasty, precocious, of danks, mayne, and kozlowski"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00251",
    "question": "What is associated with T2 hypointense basal ganglia?",
    "seeds": [
      "T2 hypointense basal ganglia"
    ],
    "gold_answer": "Abnormal basal ganglia MRI signal intensity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00252",
    "question": "What is associated with Contracture of the interphalangeal joint of the hallux?",
    "seeds": [
      "Contracture of the interphalangeal joint of the hallux"
    ],
    "gold_answer": "Flexion contracture of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00253",
    "question": "What phenotype is associated with Deafness, autosomal dominant 84?",
    "seeds": [
      "Deafness, autosomal dominant 84"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00254",
    "question": "What is associated with Conspicuously happy disposition?",
    "seeds": [
      "Conspicuously happy disposition"
    ],
    "gold_answer": "Abnormal demeanor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00255",
    "question": "What is associated with Wide proximal femoral metaphysis?",
    "seeds": [
      "Wide proximal femoral metaphysis"
    ],
    "gold_answer": "Abnormal femoral metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00256",
    "question": "What is associated with INCISORS, LONG UPPER CENTRAL?",
    "seeds": [
      "INCISORS, LONG UPPER CENTRAL"
    ],
    "gold_answer": "Incisor macrodontia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00257",
    "question": "What is associated with Enlarged epiphyses of the 4th finger?",
    "seeds": [
      "Enlarged epiphyses of the 4th finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00258",
    "question": "What is associated with Vaginal pyocele?",
    "seeds": [
      "Vaginal pyocele"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00259",
    "question": "What is associated with Anti-streptococcus deoxyribonuclease-B antibody positivity?",
    "seeds": [
      "Anti-streptococcus deoxyribonuclease-B antibody positivity"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00260",
    "question": "What is associated with Ivory epiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Ivory epiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Ivory epiphyses of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00261",
    "question": "What is associated with Dysplastic corpus callosum?",
    "seeds": [
      "Dysplastic corpus callosum"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00262",
    "question": "What is associated with Positive oropharynx poliovirus nucleic acid test?",
    "seeds": [
      "Positive oropharynx poliovirus nucleic acid test"
    ],
    "gold_answer": "Positive oropharangeal infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00263",
    "question": "What phenotype is associated with Genitourinary tract anomalies?",
    "seeds": [
      "Genitourinary tract anomalies"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00264",
    "question": "What is associated with Dentinogenesis imperfecta limited to primary teeth?",
    "seeds": [
      "Dentinogenesis imperfecta limited to primary teeth"
    ],
    "gold_answer": "Dentinogenesis imperfecta",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00265",
    "question": "What is associated with Neoplasm of the rectum?",
    "seeds": [
      "Neoplasm of the rectum"
    ],
    "gold_answer": "Abnormal large intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00266",
    "question": "What is associated with Mosaic trisomy 3 syndrome?",
    "seeds": [
      "Mosaic trisomy 3 syndrome"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00267",
    "question": "What is associated with Abnormal muscle fiber merosin expression?",
    "seeds": [
      "Abnormal muscle fiber merosin expression"
    ],
    "gold_answer": "Abnormal muscle fiber protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00268",
    "question": "What is associated with Lower eyelid edema?",
    "seeds": [
      "Lower eyelid edema"
    ],
    "gold_answer": "Palpebral edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00269",
    "question": "What is associated with Triangular epiphyses of the phalanges of the hand?",
    "seeds": [
      "Triangular epiphyses of the phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00270",
    "question": "What is associated with Decreased glucose-6-phosphate dehydrogenase level in dried blood spot?",
    "seeds": [
      "Decreased glucose-6-phosphate dehydrogenase level in dried blood spot"
    ],
    "gold_answer": "Abnormal glucose-6-phosphate dehydrogenase level in dried blood spot",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00271",
    "question": "What is associated with Hernia?",
    "seeds": [
      "Hernia"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00272",
    "question": "What is associated with Progressive distal muscular atrophy?",
    "seeds": [
      "Progressive distal muscular atrophy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00273",
    "question": "What is associated with Cervical spondylosis?",
    "seeds": [
      "Cervical spondylosis"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00274",
    "question": "What is associated with Contracture of the proximal interphalangeal joint of the 2nd toe?",
    "seeds": [
      "Contracture of the proximal interphalangeal joint of the 2nd toe"
    ],
    "gold_answer": "Abnormal second toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00275",
    "question": "What is associated with Central sleep apnea?",
    "seeds": [
      "Central sleep apnea"
    ],
    "gold_answer": "Sleep-related breathing disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00276",
    "question": "What is associated with Beaded vitreous appearance?",
    "seeds": [
      "Beaded vitreous appearance"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00277",
    "question": "What is associated with Reduced circulating leukotriene C4 concentration?",
    "seeds": [
      "Reduced circulating leukotriene C4 concentration"
    ],
    "gold_answer": "Abnormal circulating unsaturated fatty acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00278",
    "question": "What is associated with Small epiphyses of the 2nd toe?",
    "seeds": [
      "Small epiphyses of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00279",
    "question": "What is associated with Prolonged bleeding time?",
    "seeds": [
      "Prolonged bleeding time"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00280",
    "question": "What is associated with Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome?",
    "seeds": [
      "Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome"
    ],
    "gold_answer": "Abnormality of the chin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00281",
    "question": "What is associated with Hypopituitarism?",
    "seeds": [
      "Hypopituitarism"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00282",
    "question": "What is associated with Pattern dystrophy of the retina?",
    "seeds": [
      "Pattern dystrophy of the retina"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00283",
    "question": "What is associated with Abnormal platelet lysosome secretion?",
    "seeds": [
      "Abnormal platelet lysosome secretion"
    ],
    "gold_answer": "Abnormal platelet function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00284",
    "question": "What is associated with Advanced pneumatization of the mastoid process?",
    "seeds": [
      "Advanced pneumatization of the mastoid process"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00285",
    "question": "What is associated with Extremely preterm birth?",
    "seeds": [
      "Extremely preterm birth"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00286",
    "question": "What is associated with Charcot-Marie-Tooth disease, type 4D?",
    "seeds": [
      "Charcot-Marie-Tooth disease, type 4D"
    ],
    "gold_answer": "Abnormality of refraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00287",
    "question": "What is associated with Testicular neoplasm?",
    "seeds": [
      "Testicular neoplasm"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00288",
    "question": "What is associated with Volar wrist pain?",
    "seeds": [
      "Volar wrist pain"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00289",
    "question": "What is associated with Impacted tooth?",
    "seeds": [
      "Impacted tooth"
    ],
    "gold_answer": "Abnormality of dental eruption",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00290",
    "question": "What is associated with Osteolytic defects of the phalanges of the 3rd finger?",
    "seeds": [
      "Osteolytic defects of the phalanges of the 3rd finger"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00291",
    "question": "What is associated with Pseudo-fractures?",
    "seeds": [
      "Pseudo-fractures"
    ],
    "gold_answer": "Abnormal bone structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00292",
    "question": "What is associated with Aplasia of the musculature?",
    "seeds": [
      "Aplasia of the musculature"
    ],
    "gold_answer": "Abnormality of muscle size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00293",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 9/26?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 9/26"
    ],
    "gold_answer": "Severe intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00294",
    "question": "What is associated with Clinodactyly of the 4th toe?",
    "seeds": [
      "Clinodactyly of the 4th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00295",
    "question": "What is associated with Abnormal dark-adapted bright flash electroretinogram?",
    "seeds": [
      "Abnormal dark-adapted bright flash electroretinogram"
    ],
    "gold_answer": "Abnormal dark-adapted electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00296",
    "question": "What is associated with Coffin-Siris syndrome 11?",
    "seeds": [
      "Coffin-Siris syndrome 11"
    ],
    "gold_answer": "Abnormal shape of the frontal region",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00297",
    "question": "What is associated with Increased circulating aspartic acid concentration?",
    "seeds": [
      "Increased circulating aspartic acid concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00298",
    "question": "What is associated with Intrauterine limb amputation?",
    "seeds": [
      "Intrauterine limb amputation"
    ],
    "gold_answer": "Intrauterine amputation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00299",
    "question": "What is associated with Leukotriene C4 synthase deficiency?",
    "seeds": [
      "Leukotriene C4 synthase deficiency"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00300",
    "question": "What is associated with Undermodeled humerus?",
    "seeds": [
      "Undermodeled humerus"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00301",
    "question": "What phenotype is associated with Spinal muscular atrophy-Dandy-Walker malformation-cataracts syndrome?",
    "seeds": [
      "Spinal muscular atrophy-Dandy-Walker malformation-cataracts syndrome"
    ],
    "gold_answer": "EMG: chronic denervation signs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00302",
    "question": "What is associated with Hypoplastic sacrum?",
    "seeds": [
      "Hypoplastic sacrum"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00303",
    "question": "What is associated with Aplasia/Hypoplasia of the fallopian tube?",
    "seeds": [
      "Aplasia/Hypoplasia of the fallopian tube"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00304",
    "question": "What is associated with Increased HbA2 hemoglobin?",
    "seeds": [
      "Increased HbA2 hemoglobin"
    ],
    "gold_answer": "Abnormal hemoglobin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00305",
    "question": "What is associated with Increased circulating myristoleate level?",
    "seeds": [
      "Increased circulating myristoleate level"
    ],
    "gold_answer": "Abnormal circulating long-chain fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00306",
    "question": "What is associated with Confluent hypointensity of cerebral white matter on MRI?",
    "seeds": [
      "Confluent hypointensity of cerebral white matter on MRI"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00307",
    "question": "What is associated with Compound motor action potential abnormality?",
    "seeds": [
      "Compound motor action potential abnormality"
    ],
    "gold_answer": "Abnormal nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00308",
    "question": "What is associated with Abnormal myeloid cell morphology?",
    "seeds": [
      "Abnormal myeloid cell morphology"
    ],
    "gold_answer": "Abnormal bone marrow cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00309",
    "question": "What is associated with Intracranial hemorrhage?",
    "seeds": [
      "Intracranial hemorrhage"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00310",
    "question": "What is associated with Cutaneous sclerotic plaque?",
    "seeds": [
      "Cutaneous sclerotic plaque"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00311",
    "question": "What is associated with Microcephaly and chorioretinopathy, autosomal recessive, 3?",
    "seeds": [
      "Microcephaly and chorioretinopathy, autosomal recessive, 3"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00312",
    "question": "What is associated with Abnormal pelvic girdle bone morphology?",
    "seeds": [
      "Abnormal pelvic girdle bone morphology"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00313",
    "question": "What phenotype is associated with Bohring-Opitz syndrome?",
    "seeds": [
      "Bohring-Opitz syndrome"
    ],
    "gold_answer": "Progressive visual loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00314",
    "question": "What is associated with Incomplete ossification of palatine bone?",
    "seeds": [
      "Incomplete ossification of palatine bone"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00315",
    "question": "What is associated with Pseudoxanthomatous diffuse cutaneous mastocytosis?",
    "seeds": [
      "Pseudoxanthomatous diffuse cutaneous mastocytosis"
    ],
    "gold_answer": "Mastocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00316",
    "question": "What is associated with Lumbosacral hemangioma?",
    "seeds": [
      "Lumbosacral hemangioma"
    ],
    "gold_answer": "Hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00317",
    "question": "What is associated with Atrial septal defect, ostium primum type?",
    "seeds": [
      "Atrial septal defect, ostium primum type"
    ],
    "gold_answer": "Abnormal atrioventricular conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00318",
    "question": "What phenotype is associated with CHILD syndrome?",
    "seeds": [
      "CHILD syndrome"
    ],
    "gold_answer": "Multiple joint contractures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00319",
    "question": "What is associated with Intellectual developmental disorder with language impairment with or without autistic features?",
    "seeds": [
      "Intellectual developmental disorder with language impairment with or without autistic features"
    ],
    "gold_answer": "Increased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00320",
    "question": "What is associated with Impaired renal tubular reabsorption of low molecular weight protein?",
    "seeds": [
      "Impaired renal tubular reabsorption of low molecular weight protein"
    ],
    "gold_answer": "Renal tubular dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00321",
    "question": "What phenotype is associated with Congenital myopathy 26?",
    "seeds": [
      "Congenital myopathy 26"
    ],
    "gold_answer": "Distal upper limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00322",
    "question": "What is associated with Near exotropia?",
    "seeds": [
      "Near exotropia"
    ],
    "gold_answer": "Exodeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00323",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 27?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 27"
    ],
    "gold_answer": "Abnormality of somatosensory evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00324",
    "question": "What is associated with Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset?",
    "seeds": [
      "Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00325",
    "question": "What is associated with Mastocytosis, cutaneous?",
    "seeds": [
      "Mastocytosis, cutaneous"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00326",
    "question": "What is associated with Glomerular basement membrane disruption?",
    "seeds": [
      "Glomerular basement membrane disruption"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00327",
    "question": "What is associated with GNB5-related intellectual disability-cardiac arrhythmia syndrome?",
    "seeds": [
      "GNB5-related intellectual disability-cardiac arrhythmia syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00328",
    "question": "What is associated with Tracheal agenesis?",
    "seeds": [
      "Tracheal agenesis"
    ],
    "gold_answer": "Abnormal lung development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00329",
    "question": "What is associated with 1p21.3 microdeletion syndrome?",
    "seeds": [
      "1p21.3 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00330",
    "question": "What phenotype is associated with Short-Rib thoracic dysplasia 14 with polydactyly?",
    "seeds": [
      "Short-Rib thoracic dysplasia 14 with polydactyly"
    ],
    "gold_answer": "Intestinal malrotation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00331",
    "question": "What is associated with Microtia-anotia?",
    "seeds": [
      "Microtia-anotia"
    ],
    "gold_answer": "Abnormal penis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00332",
    "question": "What is associated with Short phalanx of the thumb?",
    "seeds": [
      "Short phalanx of the thumb"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00333",
    "question": "What is associated with Congenital fibrosis of extraocular muscles?",
    "seeds": [
      "Congenital fibrosis of extraocular muscles"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00334",
    "question": "What is associated with Broad forehead?",
    "seeds": [
      "Broad forehead"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00335",
    "question": "What is associated with Agammaglobulinemia 4, autosomal recessive?",
    "seeds": [
      "Agammaglobulinemia 4, autosomal recessive"
    ],
    "gold_answer": "Abnormal circulating IgM concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00336",
    "question": "What is associated with Faundes-Banka syndrome?",
    "seeds": [
      "Faundes-Banka syndrome"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00337",
    "question": "What phenotype is associated with Lethal ataxia with deafness and optic atrophy?",
    "seeds": [
      "Lethal ataxia with deafness and optic atrophy"
    ],
    "gold_answer": "Blindness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00338",
    "question": "What is associated with Atopic dermatitis?",
    "seeds": [
      "Atopic dermatitis"
    ],
    "gold_answer": "Eczematoid dermatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00339",
    "question": "What is associated with Abnormal odontoid tissue morphology?",
    "seeds": [
      "Abnormal odontoid tissue morphology"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00340",
    "question": "What is associated with Prominent supraorbital arches in adult?",
    "seeds": [
      "Prominent supraorbital arches in adult"
    ],
    "gold_answer": "Abnormality of the periorbital region",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00341",
    "question": "What is associated with Lymphatic malformation 2?",
    "seeds": [
      "Lymphatic malformation 2"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00342",
    "question": "What is associated with Triggered by monoamine oxidase inhibitor?",
    "seeds": [
      "Triggered by monoamine oxidase inhibitor"
    ],
    "gold_answer": "Triggered by exposure to medication",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00343",
    "question": "What phenotype is associated with Atrial fibrillation, familial, 3?",
    "seeds": [
      "Atrial fibrillation, familial, 3"
    ],
    "gold_answer": "Atrial fibrillation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00344",
    "question": "What phenotype is associated with Birt-Hogg-Dube syndrome?",
    "seeds": [
      "Birt-Hogg-Dube syndrome"
    ],
    "gold_answer": "Cutaneous leiomyosarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00345",
    "question": "What is associated with Fractured lateral malleolus of fibula?",
    "seeds": [
      "Fractured lateral malleolus of fibula"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00346",
    "question": "What is associated with Decreased skull ossification?",
    "seeds": [
      "Decreased skull ossification"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00347",
    "question": "What is associated with Giant hypertrophic gastritis?",
    "seeds": [
      "Giant hypertrophic gastritis"
    ],
    "gold_answer": "Abnormal stomach morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00348",
    "question": "What phenotype is associated with LARYNGOMALACIA?",
    "seeds": [
      "LARYNGOMALACIA"
    ],
    "gold_answer": "Respiratory distress",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00349",
    "question": "What is associated with Sclerotic vertebral body?",
    "seeds": [
      "Sclerotic vertebral body"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00350",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked syndromic, Snyder-Robinson type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic, Snyder-Robinson type"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00351",
    "question": "What is associated with Trigonocephaly with short stature and developmental delay?",
    "seeds": [
      "Trigonocephaly with short stature and developmental delay"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00352",
    "question": "What is associated with Increased circulating interleukin 22 concentration?",
    "seeds": [
      "Increased circulating interleukin 22 concentration"
    ],
    "gold_answer": "Abnormal circulating interleukin 22 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00353",
    "question": "What is associated with Dumbbell-shaped metaphyses?",
    "seeds": [
      "Dumbbell-shaped metaphyses"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00354",
    "question": "What is associated with Hip internal rotation contracture?",
    "seeds": [
      "Hip internal rotation contracture"
    ],
    "gold_answer": "Abnormal hip joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00355",
    "question": "What is associated with Ulnar deviation of the hand or of fingers of the hand?",
    "seeds": [
      "Ulnar deviation of the hand or of fingers of the hand"
    ],
    "gold_answer": "Deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00356",
    "question": "What is associated with Aplasia of the parotid gland?",
    "seeds": [
      "Aplasia of the parotid gland"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00357",
    "question": "What is associated with Widely-spaced incisors?",
    "seeds": [
      "Widely-spaced incisors"
    ],
    "gold_answer": "Misalignment of incisors",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00358",
    "question": "What is associated with Hypoplastic pancreas-intestinal atresia-hypoplastic gallbladder syndrome?",
    "seeds": [
      "Hypoplastic pancreas-intestinal atresia-hypoplastic gallbladder syndrome"
    ],
    "gold_answer": "RFX6",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00359",
    "question": "What is associated with Candida esophagitis?",
    "seeds": [
      "Candida esophagitis"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00360",
    "question": "What is associated with Fetal intraventricular hemorrhage with ventriculomegaly?",
    "seeds": [
      "Fetal intraventricular hemorrhage with ventriculomegaly"
    ],
    "gold_answer": "Fetal intracranial hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00361",
    "question": "What is associated with Abnormal liver lobulation?",
    "seeds": [
      "Abnormal liver lobulation"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00362",
    "question": "What is associated with Impaired Ig class switch recombination?",
    "seeds": [
      "Impaired Ig class switch recombination"
    ],
    "gold_answer": "Abnormal leukocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00363",
    "question": "What is associated with Shortening of all middle phalanges of the toes?",
    "seeds": [
      "Shortening of all middle phalanges of the toes"
    ],
    "gold_answer": "Abnormality of the middle phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00364",
    "question": "What is associated with Hemihypertrophy of lower limb?",
    "seeds": [
      "Hemihypertrophy of lower limb"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00365",
    "question": "What is associated with Acrorenal syndrome?",
    "seeds": [
      "Acrorenal syndrome"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00366",
    "question": "What is associated with Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome?",
    "seeds": [
      "Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00367",
    "question": "What is associated with Aplasia of the 1st metacarpal?",
    "seeds": [
      "Aplasia of the 1st metacarpal"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00368",
    "question": "What is associated with Myofibromatosis, infantile, 1?",
    "seeds": [
      "Myofibromatosis, infantile, 1"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00369",
    "question": "What is associated with Small intestinal stenosis?",
    "seeds": [
      "Small intestinal stenosis"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00370",
    "question": "What is associated with Glomerular extracapillary fibrin?",
    "seeds": [
      "Glomerular extracapillary fibrin"
    ],
    "gold_answer": "Abnormal Bowman space morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00371",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 43?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 43"
    ],
    "gold_answer": "Non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00372",
    "question": "What is associated with Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease?",
    "seeds": [
      "Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease"
    ],
    "gold_answer": "LMO1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_00373",
    "question": "What is associated with Sensory exotropia?",
    "seeds": [
      "Sensory exotropia"
    ],
    "gold_answer": "Exotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00374",
    "question": "What is associated with Oculocerebral hypopigmentation syndrome, Preus type?",
    "seeds": [
      "Oculocerebral hypopigmentation syndrome, Preus type"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00375",
    "question": "What is associated with Secretory IgA deficiency?",
    "seeds": [
      "Secretory IgA deficiency"
    ],
    "gold_answer": "Decreased immunoglobulin level in body fluid",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00376",
    "question": "What is associated with Poirier-Bienvenu neurodevelopmental syndrome?",
    "seeds": [
      "Poirier-Bienvenu neurodevelopmental syndrome"
    ],
    "gold_answer": "Abnormality of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00377",
    "question": "What is associated with Cortically dense long tubular bones?",
    "seeds": [
      "Cortically dense long tubular bones"
    ],
    "gold_answer": "Thickened cortex of long bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00378",
    "question": "What phenotype is associated with Mitochondrial complex IV deficiency, nuclear type 16?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 16"
    ],
    "gold_answer": "Poor head control",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00379",
    "question": "What is associated with Senior-Loken syndrome 3?",
    "seeds": [
      "Senior-Loken syndrome 3"
    ],
    "gold_answer": "Chronic kidney disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00380",
    "question": "What is associated with Duplicated tragus?",
    "seeds": [
      "Duplicated tragus"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00381",
    "question": "What is associated with Citrullinemia, type II, adult-onset?",
    "seeds": [
      "Citrullinemia, type II, adult-onset"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00382",
    "question": "What is associated with Branchiootorenal syndrome 1?",
    "seeds": [
      "Branchiootorenal syndrome 1"
    ],
    "gold_answer": "Skin tags",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00383",
    "question": "What phenotype is associated with Lipodystrophy, congenital generalized, type 3?",
    "seeds": [
      "Lipodystrophy, congenital generalized, type 3"
    ],
    "gold_answer": "Acanthosis nigricans",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00384",
    "question": "What is associated with Deep neck abscess?",
    "seeds": [
      "Deep neck abscess"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00385",
    "question": "What phenotype is associated with Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome?",
    "seeds": [
      "Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome"
    ],
    "gold_answer": "Hypospadias",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00386",
    "question": "What phenotype is associated with Citrullinemia, type II, neonatal-onset?",
    "seeds": [
      "Citrullinemia, type II, neonatal-onset"
    ],
    "gold_answer": "Hyperlysinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00387",
    "question": "What is associated with Hirschsprung disease-deafness-polydactyly syndrome?",
    "seeds": [
      "Hirschsprung disease-deafness-polydactyly syndrome"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00388",
    "question": "What is associated with Beau's lines?",
    "seeds": [
      "Beau's lines"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00389",
    "question": "What is associated with Teebi-Shaltout syndrome?",
    "seeds": [
      "Teebi-Shaltout syndrome"
    ],
    "gold_answer": "Abnormal location of ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00390",
    "question": "What is associated with Post-angioplasty coronary artery restenosis?",
    "seeds": [
      "Post-angioplasty coronary artery restenosis"
    ],
    "gold_answer": "Atherosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00391",
    "question": "What is associated with Broad distal phalanx of the 2nd toe?",
    "seeds": [
      "Broad distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00392",
    "question": "What is associated with Glomerular crescent formation?",
    "seeds": [
      "Glomerular crescent formation"
    ],
    "gold_answer": "Abnormal Bowman space morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00393",
    "question": "What phenotype is associated with Acquired angioedema?",
    "seeds": [
      "Acquired angioedema"
    ],
    "gold_answer": "Angioedema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00394",
    "question": "What is associated with Frontal cortical atrophy?",
    "seeds": [
      "Frontal cortical atrophy"
    ],
    "gold_answer": "Abnormal cerebral cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00395",
    "question": "What is associated with ABeta amyloidosis, Dutch type?",
    "seeds": [
      "ABeta amyloidosis, Dutch type"
    ],
    "gold_answer": "Intracranial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00396",
    "question": "What phenotype is associated with Amyotrophy, hereditary neuralgic?",
    "seeds": [
      "Amyotrophy, hereditary neuralgic"
    ],
    "gold_answer": "Cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00397",
    "question": "What is associated with Orofaciodigital syndrome type 4?",
    "seeds": [
      "Orofaciodigital syndrome type 4"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00398",
    "question": "What is associated with Pilonidal abscess?",
    "seeds": [
      "Pilonidal abscess"
    ],
    "gold_answer": "Abnormal immune system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00399",
    "question": "What phenotype is associated with Cardiomyopathy, dilated, 1V?",
    "seeds": [
      "Cardiomyopathy, dilated, 1V"
    ],
    "gold_answer": "Atrial fibrillation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00400",
    "question": "What phenotype is associated with Hemoglobin-Variants for which the chain carrying the mutation isunknown or uncertain?",
    "seeds": [
      "Hemoglobin-Variants for which the chain carrying the mutation isunknown or uncertain"
    ],
    "gold_answer": "Increased hemoglobin oxygen affinity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00401",
    "question": "What is associated with Recurrent infection of the gastrointestinal tract?",
    "seeds": [
      "Recurrent infection of the gastrointestinal tract"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00402",
    "question": "What is associated with Intra-oral hyperpigmentation?",
    "seeds": [
      "Intra-oral hyperpigmentation"
    ],
    "gold_answer": "Abnormal pigmentation of the oral mucosa",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00403",
    "question": "What is associated with Elevated circulating thrombopoietin concentration?",
    "seeds": [
      "Elevated circulating thrombopoietin concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00404",
    "question": "What is associated with Increased CSF/serum albumin ratio?",
    "seeds": [
      "Increased CSF/serum albumin ratio"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00405",
    "question": "What is associated with Agalactia?",
    "seeds": [
      "Agalactia"
    ],
    "gold_answer": "Abnormality of the breast",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00406",
    "question": "What is associated with Anti-GD1b antibody positivity?",
    "seeds": [
      "Anti-GD1b antibody positivity"
    ],
    "gold_answer": "Anti-ganglioside antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00407",
    "question": "What is associated with Increased urinary epithelial cell count?",
    "seeds": [
      "Increased urinary epithelial cell count"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00408",
    "question": "What is associated with Small epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Small epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Small epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00409",
    "question": "What is associated with Decreased CSF neopterin level?",
    "seeds": [
      "Decreased CSF neopterin level"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00410",
    "question": "What is associated with Elevated maternal circulating alpha-fetoprotein concentration?",
    "seeds": [
      "Elevated maternal circulating alpha-fetoprotein concentration"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00411",
    "question": "What is associated with Abnormal glucose-6-phosphate dehydrogenase level in leukocytes?",
    "seeds": [
      "Abnormal glucose-6-phosphate dehydrogenase level in leukocytes"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00412",
    "question": "What is associated with Spinal muscular atrophy, lower extremity-predominant, 1, autosomal dominant?",
    "seeds": [
      "Spinal muscular atrophy, lower extremity-predominant, 1, autosomal dominant"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00413",
    "question": "What is associated with Early onset absence seizures?",
    "seeds": [
      "Early onset absence seizures"
    ],
    "gold_answer": "Dialeptic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00414",
    "question": "What is associated with Protruding coccyx?",
    "seeds": [
      "Protruding coccyx"
    ],
    "gold_answer": "Abnormal coccyx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00415",
    "question": "What is associated with Nonimmune hydrops fetalis?",
    "seeds": [
      "Nonimmune hydrops fetalis"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00416",
    "question": "What is associated with Increased complex N-glycan level?",
    "seeds": [
      "Increased complex N-glycan level"
    ],
    "gold_answer": "Abnormal protein N-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00417",
    "question": "What is associated with Progressive clavicular acroosteolysis?",
    "seeds": [
      "Progressive clavicular acroosteolysis"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00418",
    "question": "What is associated with Hyperglycemia?",
    "seeds": [
      "Hyperglycemia"
    ],
    "gold_answer": "Abnormal blood glucose concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00419",
    "question": "What is associated with Abnormal thoracic duct morphology?",
    "seeds": [
      "Abnormal thoracic duct morphology"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00420",
    "question": "What is associated with Absent epiphyses of the proximal phalanges of the hand?",
    "seeds": [
      "Absent epiphyses of the proximal phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00421",
    "question": "What is associated with Brachydactyly-syndactyly, Zhao type?",
    "seeds": [
      "Brachydactyly-syndactyly, Zhao type"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00422",
    "question": "What is associated with Bullet-shaped thumb phalanx?",
    "seeds": [
      "Bullet-shaped thumb phalanx"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00423",
    "question": "What is associated with Monoclonal elevation of IgG light chain?",
    "seeds": [
      "Monoclonal elevation of IgG light chain"
    ],
    "gold_answer": "Abnormal circulating IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00424",
    "question": "What is associated with Increased circulating interferon-gamma concentration?",
    "seeds": [
      "Increased circulating interferon-gamma concentration"
    ],
    "gold_answer": "Abnormal circulating interferon-gamma concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00425",
    "question": "What is associated with Glomerular endothelial tubuloreticular inclusion?",
    "seeds": [
      "Glomerular endothelial tubuloreticular inclusion"
    ],
    "gold_answer": "Abnormal glomerular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00426",
    "question": "What phenotype is associated with Amelogenesis imperfecta, type IA?",
    "seeds": [
      "Amelogenesis imperfecta, type IA"
    ],
    "gold_answer": "Taurodontia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00427",
    "question": "What phenotype is associated with Immunodeficiency due to purine nucleoside phosphorylase deficiency?",
    "seeds": [
      "Immunodeficiency due to purine nucleoside phosphorylase deficiency"
    ],
    "gold_answer": "Sinusitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00428",
    "question": "What is associated with Hyper-IgM syndrome type 3?",
    "seeds": [
      "Hyper-IgM syndrome type 3"
    ],
    "gold_answer": "CD40",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00429",
    "question": "What is associated with Hypoplastic left atrium?",
    "seeds": [
      "Hypoplastic left atrium"
    ],
    "gold_answer": "Abnormal left atrium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00430",
    "question": "What is associated with Fatigable weakness of swallowing muscles?",
    "seeds": [
      "Fatigable weakness of swallowing muscles"
    ],
    "gold_answer": "Fatigable weakness of bulbar muscles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00431",
    "question": "What is associated with Facial palsy?",
    "seeds": [
      "Facial palsy"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00432",
    "question": "What is associated with Biliary dyskinesia?",
    "seeds": [
      "Biliary dyskinesia"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00433",
    "question": "What is associated with Cystic hamartoma of lung and kidney?",
    "seeds": [
      "Cystic hamartoma of lung and kidney"
    ],
    "gold_answer": "Increased blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00434",
    "question": "What is associated with Increased circulating IgE concentration?",
    "seeds": [
      "Increased circulating IgE concentration"
    ],
    "gold_answer": "Abnormal circulating IgE concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00435",
    "question": "What is associated with Asymmetrical gluteal crease?",
    "seeds": [
      "Asymmetrical gluteal crease"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00436",
    "question": "What is associated with Dysgenesis of the hypothalamus?",
    "seeds": [
      "Dysgenesis of the hypothalamus"
    ],
    "gold_answer": "Abnormal diencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00437",
    "question": "What is associated with Irregular epiphysis of the 1st metatarsal?",
    "seeds": [
      "Irregular epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00438",
    "question": "What is associated with Immune defect due to absence of thymus?",
    "seeds": [
      "Immune defect due to absence of thymus"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00439",
    "question": "What is associated with Ingrown nail?",
    "seeds": [
      "Ingrown nail"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00440",
    "question": "What is associated with Periorbital dermoid cyst?",
    "seeds": [
      "Periorbital dermoid cyst"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00441",
    "question": "What is associated with Duplication of the middle phalanx of the 4th finger?",
    "seeds": [
      "Duplication of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00442",
    "question": "What phenotype is associated with Renal hypodysplasia/aplasia 2?",
    "seeds": [
      "Renal hypodysplasia/aplasia 2"
    ],
    "gold_answer": "Potter facies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00443",
    "question": "What phenotype is associated with Aicardi-Goutieres syndrome 4?",
    "seeds": [
      "Aicardi-Goutieres syndrome 4"
    ],
    "gold_answer": "Dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00444",
    "question": "What is associated with Rubeosis iridis?",
    "seeds": [
      "Rubeosis iridis"
    ],
    "gold_answer": "Abnormal uvea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00445",
    "question": "What is associated with Alsahan-Harris syndrome?",
    "seeds": [
      "Alsahan-Harris syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the skull",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00446",
    "question": "What is associated with Bardet-Biedl syndrome 20?",
    "seeds": [
      "Bardet-Biedl syndrome 20"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00447",
    "question": "What is associated with Fg syndrome 2?",
    "seeds": [
      "Fg syndrome 2"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00448",
    "question": "What phenotype is associated with Tuberous sclerosis complex?",
    "seeds": [
      "Tuberous sclerosis complex"
    ],
    "gold_answer": "Shagreen patch",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00449",
    "question": "What phenotype is associated with Optic atrophy 16?",
    "seeds": [
      "Optic atrophy 16"
    ],
    "gold_answer": "Dyschromatopsia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00450",
    "question": "What is associated with Caudal appendage?",
    "seeds": [
      "Caudal appendage"
    ],
    "gold_answer": "Abnormal coccyx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00451",
    "question": "What phenotype is associated with Keratoderma, palmoplantar, punctate type IA?",
    "seeds": [
      "Keratoderma, palmoplantar, punctate type IA"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00452",
    "question": "What is associated with Absent dorsal skin creases over affected joints?",
    "seeds": [
      "Absent dorsal skin creases over affected joints"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00453",
    "question": "What is associated with Congenital posterior urethral valve?",
    "seeds": [
      "Congenital posterior urethral valve"
    ],
    "gold_answer": "Urethral valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00454",
    "question": "What phenotype is associated with Deafness, neurosensory, autosomal recessive 2?",
    "seeds": [
      "Deafness, neurosensory, autosomal recessive 2"
    ],
    "gold_answer": "Vertigo",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00455",
    "question": "What is associated with Ground glass opacity of humeral diaphysis?",
    "seeds": [
      "Ground glass opacity of humeral diaphysis"
    ],
    "gold_answer": "Anomaly of the upper limb diaphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00456",
    "question": "What is associated with Episodic paroxysmal anxiety?",
    "seeds": [
      "Episodic paroxysmal anxiety"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00457",
    "question": "What is associated with Unilateral sensorineural hearing impairment?",
    "seeds": [
      "Unilateral sensorineural hearing impairment"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00458",
    "question": "What is associated with Thrombocytopenia 3?",
    "seeds": [
      "Thrombocytopenia 3"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00459",
    "question": "What is associated with Absent facial hair?",
    "seeds": [
      "Absent facial hair"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00460",
    "question": "What is associated with Irregular epiphyses of the metacarpals?",
    "seeds": [
      "Irregular epiphyses of the metacarpals"
    ],
    "gold_answer": "Irregular epiphyses of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00461",
    "question": "What is associated with Cardiomyopathy, dilated, 1B?",
    "seeds": [
      "Cardiomyopathy, dilated, 1B"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00462",
    "question": "What is associated with Benign neoplasm of the central nervous system?",
    "seeds": [
      "Benign neoplasm of the central nervous system"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00463",
    "question": "What is associated with Biotinidase deficiency?",
    "seeds": [
      "Biotinidase deficiency"
    ],
    "gold_answer": "Ketoacidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00464",
    "question": "What phenotype is associated with Microcephaly, short stature, and polymicrogyria with or without seizures?",
    "seeds": [
      "Microcephaly, short stature, and polymicrogyria with or without seizures"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00465",
    "question": "What is associated with Cogan syndrome?",
    "seeds": [
      "Cogan syndrome"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00466",
    "question": "What is associated with Hypertrichosis?",
    "seeds": [
      "Hypertrichosis"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00467",
    "question": "What is associated with Microcephalic primordial dwarfism, Montreal type?",
    "seeds": [
      "Microcephalic primordial dwarfism, Montreal type"
    ],
    "gold_answer": "Premature skin wrinkling",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00468",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 9?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 9"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00469",
    "question": "What is associated with Abnormal palmar dermal ridges?",
    "seeds": [
      "Abnormal palmar dermal ridges"
    ],
    "gold_answer": "Abnormal dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00470",
    "question": "What is associated with IMINOGLYCINURIA?",
    "seeds": [
      "IMINOGLYCINURIA"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00471",
    "question": "What is associated with Intellectual disability-small hands and feet-drug-resistant epilepsy syndrome?",
    "seeds": [
      "Intellectual disability-small hands and feet-drug-resistant epilepsy syndrome"
    ],
    "gold_answer": "SMC1A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00472",
    "question": "What is associated with Hyperphalangy of the 2nd finger?",
    "seeds": [
      "Hyperphalangy of the 2nd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00473",
    "question": "What is associated with Bullet-shaped 2nd toe phalanx?",
    "seeds": [
      "Bullet-shaped 2nd toe phalanx"
    ],
    "gold_answer": "Abnormal second toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00474",
    "question": "What is associated with Jerky head movements?",
    "seeds": [
      "Jerky head movements"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00475",
    "question": "What phenotype is associated with Spinocerebellar ataxia, autosomal recessive 20?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 20"
    ],
    "gold_answer": "Delayed ability to sit",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00476",
    "question": "What is associated with Aspergillosis?",
    "seeds": [
      "Aspergillosis"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00477",
    "question": "What is associated with Abnormal vestibular saccule morphology?",
    "seeds": [
      "Abnormal vestibular saccule morphology"
    ],
    "gold_answer": "Abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00478",
    "question": "What is associated with Triggered by excitement?",
    "seeds": [
      "Triggered by excitement"
    ],
    "gold_answer": "Triggered by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00479",
    "question": "What is associated with Triangular epiphysis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Triangular epiphysis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Triangular epiphyses of the distal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00480",
    "question": "What is associated with Pleuritic chest pain?",
    "seeds": [
      "Pleuritic chest pain"
    ],
    "gold_answer": "Chest pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00481",
    "question": "What is associated with Increased circulating myristoleate level?",
    "seeds": [
      "Increased circulating myristoleate level"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00482",
    "question": "What is associated with Increased hepatitis B virus antibody level?",
    "seeds": [
      "Increased hepatitis B virus antibody level"
    ],
    "gold_answer": "Increased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00483",
    "question": "What is associated with Partial absence of cerebellar vermis?",
    "seeds": [
      "Partial absence of cerebellar vermis"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00484",
    "question": "What is associated with Starch intolerance?",
    "seeds": [
      "Starch intolerance"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00485",
    "question": "What is associated with Athetoid cerebral palsy?",
    "seeds": [
      "Athetoid cerebral palsy"
    ],
    "gold_answer": "Cerebral palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00486",
    "question": "What is associated with Acute encephalopathy?",
    "seeds": [
      "Acute encephalopathy"
    ],
    "gold_answer": "Encephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00487",
    "question": "What is associated with Ventricular septal defect 3?",
    "seeds": [
      "Ventricular septal defect 3"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00488",
    "question": "What is associated with Glomerular synechial adhesion?",
    "seeds": [
      "Glomerular synechial adhesion"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00489",
    "question": "What is associated with Parkinsonism with spasticity, X-linked?",
    "seeds": [
      "Parkinsonism with spasticity, X-linked"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00490",
    "question": "What is associated with Paracentral scotoma?",
    "seeds": [
      "Paracentral scotoma"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00491",
    "question": "What is associated with Multiple mitochondrial dysfunctions syndrome 4?",
    "seeds": [
      "Multiple mitochondrial dysfunctions syndrome 4"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00492",
    "question": "What is associated with Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome?",
    "seeds": [
      "Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome"
    ],
    "gold_answer": "KIF14",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_00493",
    "question": "What is associated with Impaired ability to shift attention?",
    "seeds": [
      "Impaired ability to shift attention"
    ],
    "gold_answer": "Impaired executive functioning",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00494",
    "question": "What is associated with Patchy sclerosis of the 1st metacarpal?",
    "seeds": [
      "Patchy sclerosis of the 1st metacarpal"
    ],
    "gold_answer": "Sclerosis of the 1st metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00495",
    "question": "What phenotype is associated with Focal facial dermal dysplasia type I?",
    "seeds": [
      "Focal facial dermal dysplasia type I"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00496",
    "question": "What is associated with Pulmonary artery atresia?",
    "seeds": [
      "Pulmonary artery atresia"
    ],
    "gold_answer": "Abnormality of the pulmonary vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00497",
    "question": "What is associated with Laryngeal calcification?",
    "seeds": [
      "Laryngeal calcification"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00498",
    "question": "What is associated with Cardiomyocyte mitochondrial proliferation?",
    "seeds": [
      "Cardiomyocyte mitochondrial proliferation"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00499",
    "question": "What phenotype is associated with Seizures, cortical blindness, and microcephaly syndrome?",
    "seeds": [
      "Seizures, cortical blindness, and microcephaly syndrome"
    ],
    "gold_answer": "Focal cortical dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00500",
    "question": "What is associated with Reduced epidermal collagen VII protein expression?",
    "seeds": [
      "Reduced epidermal collagen VII protein expression"
    ],
    "gold_answer": "Abnormal epidermal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00501",
    "question": "What is associated with Dimple on nasal tip?",
    "seeds": [
      "Dimple on nasal tip"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00502",
    "question": "What is associated with Anterior chamber cells grade 4+?",
    "seeds": [
      "Anterior chamber cells grade 4+"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00503",
    "question": "What phenotype is associated with Adult acute respiratory distress syndrome?",
    "seeds": [
      "Adult acute respiratory distress syndrome"
    ],
    "gold_answer": "Shock",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00504",
    "question": "What is associated with Neonatal inspiratory stridor?",
    "seeds": [
      "Neonatal inspiratory stridor"
    ],
    "gold_answer": "Respiratory insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00505",
    "question": "What is associated with EEG with generalized slow activity grade 1?",
    "seeds": [
      "EEG with generalized slow activity grade 1"
    ],
    "gold_answer": "EEG with generalized slow activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00506",
    "question": "What is associated with Immunodeficiency 53?",
    "seeds": [
      "Immunodeficiency 53"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00507",
    "question": "What phenotype is associated with Folinic acid-responsive seizures?",
    "seeds": [
      "Folinic acid-responsive seizures"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00508",
    "question": "What is associated with Right ventricular failure?",
    "seeds": [
      "Right ventricular failure"
    ],
    "gold_answer": "Abnormal right ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00509",
    "question": "What phenotype is associated with Peroxisome biogenesis disorder 4B?",
    "seeds": [
      "Peroxisome biogenesis disorder 4B"
    ],
    "gold_answer": "Single transverse palmar crease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00510",
    "question": "What is associated with Pyuria?",
    "seeds": [
      "Pyuria"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00511",
    "question": "What is associated with Microcephalic osteodysplastic primordial dwarfism type II?",
    "seeds": [
      "Microcephalic osteodysplastic primordial dwarfism type II"
    ],
    "gold_answer": "Hypopigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00512",
    "question": "What is associated with Reduced neutrophil myeloperoxidase activity?",
    "seeds": [
      "Reduced neutrophil myeloperoxidase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00513",
    "question": "What is associated with Abnormal liver enzyme activity or concentration?",
    "seeds": [
      "Abnormal liver enzyme activity or concentration"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00514",
    "question": "What phenotype is associated with Crisponi syndrome?",
    "seeds": [
      "Crisponi syndrome"
    ],
    "gold_answer": "High palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00515",
    "question": "What is associated with Developmental delay with sleep apnea?",
    "seeds": [
      "Developmental delay with sleep apnea"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00516",
    "question": "What is associated with Pulsatile liver?",
    "seeds": [
      "Pulsatile liver"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00517",
    "question": "What is associated with Abnormal posterior circulating artery morphology?",
    "seeds": [
      "Abnormal posterior circulating artery morphology"
    ],
    "gold_answer": "Abnormal circle of Willis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00518",
    "question": "What is associated with Auriculocondylar syndrome 3?",
    "seeds": [
      "Auriculocondylar syndrome 3"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00519",
    "question": "What is associated with Pulmonary cavity?",
    "seeds": [
      "Pulmonary cavity"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00520",
    "question": "What is associated with Elevated imprint of the transverse sinuses?",
    "seeds": [
      "Elevated imprint of the transverse sinuses"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00521",
    "question": "What is associated with Abnormal cervical spine morphology?",
    "seeds": [
      "Abnormal cervical spine morphology"
    ],
    "gold_answer": "Abnormality of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00522",
    "question": "What phenotype is associated with Meester-Loeys syndrome?",
    "seeds": [
      "Meester-Loeys syndrome"
    ],
    "gold_answer": "Poor wound healing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00523",
    "question": "What is associated with Elevated urinary pyrroline hydroxycarboxylic acid level?",
    "seeds": [
      "Elevated urinary pyrroline hydroxycarboxylic acid level"
    ],
    "gold_answer": "Organic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00524",
    "question": "What is associated with Optic atrophy 8?",
    "seeds": [
      "Optic atrophy 8"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00525",
    "question": "What is associated with Combined immunodeficiency due to CRAC channel dysfunction?",
    "seeds": [
      "Combined immunodeficiency due to CRAC channel dysfunction"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00526",
    "question": "What is associated with Transient unilateral blurring of vision?",
    "seeds": [
      "Transient unilateral blurring of vision"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00527",
    "question": "What is associated with Unossified vertebral bodies?",
    "seeds": [
      "Unossified vertebral bodies"
    ],
    "gold_answer": "Abnormally ossified vertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00528",
    "question": "What is associated with Enlarged epiphysis of the distal phalanx of the 4th finger?",
    "seeds": [
      "Enlarged epiphysis of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00529",
    "question": "What is associated with Rosenthal fibers?",
    "seeds": [
      "Rosenthal fibers"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00530",
    "question": "What is associated with Spondylometaphyseal dysplasia, 'corner fracture' type?",
    "seeds": [
      "Spondylometaphyseal dysplasia, 'corner fracture' type"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00531",
    "question": "What is associated with Fetal cystic hygroma?",
    "seeds": [
      "Fetal cystic hygroma"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00532",
    "question": "What is associated with Fused labia minora?",
    "seeds": [
      "Fused labia minora"
    ],
    "gold_answer": "Abnormal labia minora morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00533",
    "question": "What is associated with Bunionette deformity?",
    "seeds": [
      "Bunionette deformity"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00534",
    "question": "What is associated with Gastrointestinal carcinoma?",
    "seeds": [
      "Gastrointestinal carcinoma"
    ],
    "gold_answer": "Malignant gastrointestinal tract tumors",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00535",
    "question": "What is associated with Lateral venous anomaly?",
    "seeds": [
      "Lateral venous anomaly"
    ],
    "gold_answer": "Prominent superficial veins",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00536",
    "question": "What is associated with Abnormal head movements?",
    "seeds": [
      "Abnormal head movements"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00537",
    "question": "What is associated with Contractures-developmental delay-Pierre Robin syndrome?",
    "seeds": [
      "Contractures-developmental delay-Pierre Robin syndrome"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00538",
    "question": "What phenotype is associated with Metaphyseal dysplasia without hypotrichosis?",
    "seeds": [
      "Metaphyseal dysplasia without hypotrichosis"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00539",
    "question": "What is associated with Sclerosis of the proximal phalanx of the 3rd toe?",
    "seeds": [
      "Sclerosis of the proximal phalanx of the 3rd toe"
    ],
    "gold_answer": "Sclerosis of proximal phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00540",
    "question": "What phenotype is associated with Fibronectin glomerulopathy?",
    "seeds": [
      "Fibronectin glomerulopathy"
    ],
    "gold_answer": "Mesangial abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00541",
    "question": "What phenotype is associated with Nystagmus, congenital motor, autosomal recessive?",
    "seeds": [
      "Nystagmus, congenital motor, autosomal recessive"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00542",
    "question": "What phenotype is associated with Proximal 3rd toe symphalangism?",
    "seeds": [
      "Proximal 3rd toe symphalangism"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00543",
    "question": "What is associated with Periportal emperipolesis?",
    "seeds": [
      "Periportal emperipolesis"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00544",
    "question": "What is associated with Abnormal timing of dark-adapted dim flash electroretinogram?",
    "seeds": [
      "Abnormal timing of dark-adapted dim flash electroretinogram"
    ],
    "gold_answer": "Abnormal dark-adapted dim flash electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00545",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 3?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 3"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00546",
    "question": "What is associated with Abnormal thalamic MRI signal intensity?",
    "seeds": [
      "Abnormal thalamic MRI signal intensity"
    ],
    "gold_answer": "Abnormal diencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00547",
    "question": "What is associated with Primary erythromelalgia?",
    "seeds": [
      "Primary erythromelalgia"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00548",
    "question": "What phenotype is associated with Split lower lip?",
    "seeds": [
      "Split lower lip"
    ],
    "gold_answer": "Abnormal lower lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00549",
    "question": "What phenotype is associated with Congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome?",
    "seeds": [
      "Congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome"
    ],
    "gold_answer": "Axial hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00550",
    "question": "What is associated with Blue cone monochromacy?",
    "seeds": [
      "Blue cone monochromacy"
    ],
    "gold_answer": "Monochromacy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00551",
    "question": "What is associated with Autosomal dominant adult-onset proximal spinal muscular atrophy?",
    "seeds": [
      "Autosomal dominant adult-onset proximal spinal muscular atrophy"
    ],
    "gold_answer": "Limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00552",
    "question": "What is associated with Fibrotic non-specific interstitial pneumonia?",
    "seeds": [
      "Fibrotic non-specific interstitial pneumonia"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00553",
    "question": "What is associated with Limb-Mammary syndrome?",
    "seeds": [
      "Limb-Mammary syndrome"
    ],
    "gold_answer": "Abnormal nasolacrimal system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00554",
    "question": "What is associated with Tendon pain?",
    "seeds": [
      "Tendon pain"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00555",
    "question": "What is associated with 46,xx sex reversal 4?",
    "seeds": [
      "46,xx sex reversal 4"
    ],
    "gold_answer": "Hypoplasia of penis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00556",
    "question": "What is associated with Neuromuscular disease and ocular or auditory anomalies with or without seizures?",
    "seeds": [
      "Neuromuscular disease and ocular or auditory anomalies with or without seizures"
    ],
    "gold_answer": "Talipes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00557",
    "question": "What is associated with Positive CSF Tropheryma whipplei bacteria microscopy?",
    "seeds": [
      "Positive CSF Tropheryma whipplei bacteria microscopy"
    ],
    "gold_answer": "Positive CSF infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00558",
    "question": "What is associated with Arcuate vein medial/intimal liquefactive necrosis?",
    "seeds": [
      "Arcuate vein medial/intimal liquefactive necrosis"
    ],
    "gold_answer": "Abnormal arcuate vein intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00559",
    "question": "What is associated with DERMATOGLYPHICS--HYPOTHENAR RADIAL ARCH?",
    "seeds": [
      "DERMATOGLYPHICS--HYPOTHENAR RADIAL ARCH"
    ],
    "gold_answer": "Abnormal palm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00560",
    "question": "What is associated with Non-progressive cerebellar ataxia with intellectual disability?",
    "seeds": [
      "Non-progressive cerebellar ataxia with intellectual disability"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00561",
    "question": "What is associated with Anomalous origin of the left anterior descending artery from the pulmonary artery?",
    "seeds": [
      "Anomalous origin of the left anterior descending artery from the pulmonary artery"
    ],
    "gold_answer": "Abnormal coronary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00562",
    "question": "What phenotype is associated with Neurodevelopmental disorder with hypotonia and seizures?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia and seizures"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00563",
    "question": "What phenotype is associated with Keratosis follicularis spinulosa decalvans?",
    "seeds": [
      "Keratosis follicularis spinulosa decalvans"
    ],
    "gold_answer": "Sparse eyebrow",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00564",
    "question": "What is associated with Deafness, autosomal recessive 32, with or without immotile sperm?",
    "seeds": [
      "Deafness, autosomal recessive 32, with or without immotile sperm"
    ],
    "gold_answer": "Reduced sperm motility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00565",
    "question": "What is associated with Pretragal ectopia?",
    "seeds": [
      "Pretragal ectopia"
    ],
    "gold_answer": "Abnormal periauricular region morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00566",
    "question": "What is associated with Fish odor?",
    "seeds": [
      "Fish odor"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00567",
    "question": "What is associated with Amyloid deposition by anatomical site?",
    "seeds": [
      "Amyloid deposition by anatomical site"
    ],
    "gold_answer": "Amyloid deposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00568",
    "question": "What is associated with Positive CSF herpes simplex virus nucleic acid test?",
    "seeds": [
      "Positive CSF herpes simplex virus nucleic acid test"
    ],
    "gold_answer": "Positive CSF infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00569",
    "question": "What is associated with Apneic episodes in infancy?",
    "seeds": [
      "Apneic episodes in infancy"
    ],
    "gold_answer": "Apnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00570",
    "question": "What is associated with Ankyloblepharon filiforme adnatum-cleft palate syndrome?",
    "seeds": [
      "Ankyloblepharon filiforme adnatum-cleft palate syndrome"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00571",
    "question": "What is associated with Abnormal scleral thickness?",
    "seeds": [
      "Abnormal scleral thickness"
    ],
    "gold_answer": "Abnormal sclera morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00572",
    "question": "What is associated with Thin ear helix?",
    "seeds": [
      "Thin ear helix"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00573",
    "question": "What is associated with Large foramen magnum?",
    "seeds": [
      "Large foramen magnum"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00574",
    "question": "What is associated with Polydactyly, postaxial, type A10?",
    "seeds": [
      "Polydactyly, postaxial, type A10"
    ],
    "gold_answer": "IQCE",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00575",
    "question": "What is associated with Hypoplasia of right ventricle?",
    "seeds": [
      "Hypoplasia of right ventricle"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00576",
    "question": "What is associated with Erythroderma, lethal congenital?",
    "seeds": [
      "Erythroderma, lethal congenital"
    ],
    "gold_answer": "Abnormal circulating albumin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00577",
    "question": "What is associated with VACTERL association, X-linked?",
    "seeds": [
      "VACTERL association, X-linked"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00578",
    "question": "What phenotype is associated with Recurrent respiratory papillomatosis?",
    "seeds": [
      "Recurrent respiratory papillomatosis"
    ],
    "gold_answer": "Dysphagia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00579",
    "question": "What is associated with Bidirectional ventricular ectopy?",
    "seeds": [
      "Bidirectional ventricular ectopy"
    ],
    "gold_answer": "Ventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00580",
    "question": "What is associated with Pituicytoma?",
    "seeds": [
      "Pituicytoma"
    ],
    "gold_answer": "Abnormal circulating testosterone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00581",
    "question": "What is associated with Abnormal finger phalanx morphology?",
    "seeds": [
      "Abnormal finger phalanx morphology"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00582",
    "question": "What phenotype is associated with Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency?",
    "seeds": [
      "Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency"
    ],
    "gold_answer": "Broad metatarsal",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00583",
    "question": "What is associated with Vasculopathy, retinal, with cerebral leukodystrophy?",
    "seeds": [
      "Vasculopathy, retinal, with cerebral leukodystrophy"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00584",
    "question": "What phenotype is associated with Fanconi anemia, complementation group J?",
    "seeds": [
      "Fanconi anemia, complementation group J"
    ],
    "gold_answer": "Multiple cafe-au-lait spots",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00585",
    "question": "What phenotype is associated with Basal cell nevus syndrome?",
    "seeds": [
      "Basal cell nevus syndrome"
    ],
    "gold_answer": "Hemivertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00586",
    "question": "What is associated with Cutaneous necrosis?",
    "seeds": [
      "Cutaneous necrosis"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00587",
    "question": "What is associated with Increased urine phenylacetylglutamine level?",
    "seeds": [
      "Increased urine phenylacetylglutamine level"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00588",
    "question": "What is associated with Congenital nephrotic syndrome?",
    "seeds": [
      "Congenital nephrotic syndrome"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00589",
    "question": "What is associated with Transitional atrioventricular canal defect?",
    "seeds": [
      "Transitional atrioventricular canal defect"
    ],
    "gold_answer": "Atrioventricular canal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00590",
    "question": "What is associated with Pilonidal sinus?",
    "seeds": [
      "Pilonidal sinus"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00591",
    "question": "What is associated with Abnormal pulmonary valve morphology?",
    "seeds": [
      "Abnormal pulmonary valve morphology"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00592",
    "question": "What is associated with Foveal retinal pigment epithelial loss on macular OCT?",
    "seeds": [
      "Foveal retinal pigment epithelial loss on macular OCT"
    ],
    "gold_answer": "Abnormal retinal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00593",
    "question": "What is associated with Short nasal bridge?",
    "seeds": [
      "Short nasal bridge"
    ],
    "gold_answer": "Abnormal nasal bridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00594",
    "question": "What is associated with Myoclonic status epilepticus without coma?",
    "seeds": [
      "Myoclonic status epilepticus without coma"
    ],
    "gold_answer": "Myoclonic status epilepticus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00595",
    "question": "What is associated with Benign chronic pemphigus?",
    "seeds": [
      "Benign chronic pemphigus"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00596",
    "question": "What is associated with Long clavicles?",
    "seeds": [
      "Long clavicles"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00597",
    "question": "What is associated with Short 3rd toe?",
    "seeds": [
      "Short 3rd toe"
    ],
    "gold_answer": "Short toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00598",
    "question": "What is associated with Severe combined immunodeficiency, X-linked?",
    "seeds": [
      "Severe combined immunodeficiency, X-linked"
    ],
    "gold_answer": "Immunodeficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00599",
    "question": "What is associated with Chronic cutaneous wound?",
    "seeds": [
      "Chronic cutaneous wound"
    ],
    "gold_answer": "Cutaneous wound",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00600",
    "question": "What is associated with Bullet-shaped distal phalanx of the 4th toe?",
    "seeds": [
      "Bullet-shaped distal phalanx of the 4th toe"
    ],
    "gold_answer": "Bullet-shaped toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00601",
    "question": "What is associated with Hypoxanthine guanine phosphoribosyltransferase partial deficiency?",
    "seeds": [
      "Hypoxanthine guanine phosphoribosyltransferase partial deficiency"
    ],
    "gold_answer": "Hematuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00602",
    "question": "What is associated with Glomerular fibrin thrombus?",
    "seeds": [
      "Glomerular fibrin thrombus"
    ],
    "gold_answer": "Abnormal glomerular capillary lumen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00603",
    "question": "What phenotype is associated with Homocystinuria due to methylene tetrahydrofolate reductase deficiency?",
    "seeds": [
      "Homocystinuria due to methylene tetrahydrofolate reductase deficiency"
    ],
    "gold_answer": "Cystathioninemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00604",
    "question": "What is associated with H syndrome?",
    "seeds": [
      "H syndrome"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00605",
    "question": "What is associated with Fetal valproate spectrum disorder?",
    "seeds": [
      "Fetal valproate spectrum disorder"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00606",
    "question": "What is associated with Shoulder impingement?",
    "seeds": [
      "Shoulder impingement"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00607",
    "question": "What is associated with Multiple mitochondrial DNA deletions?",
    "seeds": [
      "Multiple mitochondrial DNA deletions"
    ],
    "gold_answer": "Muscle abnormality related to mitochondrial dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00608",
    "question": "What phenotype is associated with Muscular hypertonia, lethal?",
    "seeds": [
      "Muscular hypertonia, lethal"
    ],
    "gold_answer": "Decreased fetal movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00609",
    "question": "What is associated with Thought echo?",
    "seeds": [
      "Thought echo"
    ],
    "gold_answer": "Delusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00610",
    "question": "What is associated with Auralcephalosyndactyly?",
    "seeds": [
      "Auralcephalosyndactyly"
    ],
    "gold_answer": "Abnormal cranial suture/fontanelle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00611",
    "question": "What is associated with Alveolar echinococcosis?",
    "seeds": [
      "Alveolar echinococcosis"
    ],
    "gold_answer": "Visceromegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00612",
    "question": "What is associated with Abnormal morphology of musculature of pharynx?",
    "seeds": [
      "Abnormal morphology of musculature of pharynx"
    ],
    "gold_answer": "Abnormality of the pharynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00613",
    "question": "What is associated with Bilateral wrist flexion contracture?",
    "seeds": [
      "Bilateral wrist flexion contracture"
    ],
    "gold_answer": "Wrist flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00614",
    "question": "What is associated with Squamous cell carcinoma of the anal canal?",
    "seeds": [
      "Squamous cell carcinoma of the anal canal"
    ],
    "gold_answer": "Neoplasm of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00615",
    "question": "What is associated with Interstitial lung disease due to ABCA3 deficiency?",
    "seeds": [
      "Interstitial lung disease due to ABCA3 deficiency"
    ],
    "gold_answer": "ABCA3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_00616",
    "question": "What is associated with Prominent palmar flexion creases?",
    "seeds": [
      "Prominent palmar flexion creases"
    ],
    "gold_answer": "Abnormality of the palmar creases",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00617",
    "question": "What is associated with Aplasia/Hypoplasia of the optic nerve?",
    "seeds": [
      "Aplasia/Hypoplasia of the optic nerve"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00618",
    "question": "What is associated with Tibial bowing?",
    "seeds": [
      "Tibial bowing"
    ],
    "gold_answer": "Bowing of the long bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00619",
    "question": "What is associated with Low plasma citrulline?",
    "seeds": [
      "Low plasma citrulline"
    ],
    "gold_answer": "Abnormal circulating citrulline concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00620",
    "question": "What is associated with Enlargement of the ankles?",
    "seeds": [
      "Enlargement of the ankles"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00621",
    "question": "What is associated with Anonychia with flexural pigmentation?",
    "seeds": [
      "Anonychia with flexural pigmentation"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00622",
    "question": "What is associated with Punctate periventricular T2 hyperintense foci?",
    "seeds": [
      "Punctate periventricular T2 hyperintense foci"
    ],
    "gold_answer": "Leukoencephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00623",
    "question": "What is associated with Optic disc coloboma?",
    "seeds": [
      "Optic disc coloboma"
    ],
    "gold_answer": "Abnormal optic disc morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00624",
    "question": "What is associated with Coronary sinus atrial septal defect?",
    "seeds": [
      "Coronary sinus atrial septal defect"
    ],
    "gold_answer": "Abnormal cardiac septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00625",
    "question": "What is associated with Primary congenital glaucoma?",
    "seeds": [
      "Primary congenital glaucoma"
    ],
    "gold_answer": "Developmental glaucoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00626",
    "question": "What is associated with Bird-like facies?",
    "seeds": [
      "Bird-like facies"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00627",
    "question": "What is associated with Epilepsy with eyelid myoclonia?",
    "seeds": [
      "Epilepsy with eyelid myoclonia"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00628",
    "question": "What phenotype is associated with X-linked intellectual disability, Stoll type?",
    "seeds": [
      "X-linked intellectual disability, Stoll type"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00629",
    "question": "What is associated with Silver-Russell syndrome 4?",
    "seeds": [
      "Silver-Russell syndrome 4"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00630",
    "question": "What is associated with Amyotrophy of the musculature of the pelvis?",
    "seeds": [
      "Amyotrophy of the musculature of the pelvis"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the musculature of the pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00631",
    "question": "What is associated with Mesomelic limb shortening and bowing?",
    "seeds": [
      "Mesomelic limb shortening and bowing"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00632",
    "question": "What is associated with Hypocalciuric hypercalcemia, familial, type I?",
    "seeds": [
      "Hypocalciuric hypercalcemia, familial, type I"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00633",
    "question": "What phenotype is associated with Craniofrontonasal syndrome?",
    "seeds": [
      "Craniofrontonasal syndrome"
    ],
    "gold_answer": "Agenesis of corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00634",
    "question": "What is associated with Retinitis pigmentosa 4?",
    "seeds": [
      "Retinitis pigmentosa 4"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00635",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly"
    ],
    "gold_answer": "Megalencephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00636",
    "question": "What is associated with Single umbilical artery?",
    "seeds": [
      "Single umbilical artery"
    ],
    "gold_answer": "Fetal ultrasound soft marker",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00637",
    "question": "What is associated with Elevated circulating tetracosanoic acid concentration?",
    "seeds": [
      "Elevated circulating tetracosanoic acid concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00638",
    "question": "What is associated with Dent disease 2?",
    "seeds": [
      "Dent disease 2"
    ],
    "gold_answer": "Abnormal abdominal wall morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00639",
    "question": "What is associated with EEG with intermittent slow activity?",
    "seeds": [
      "EEG with intermittent slow activity"
    ],
    "gold_answer": "EEG with generalized slow activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00640",
    "question": "What is associated with Cardiomyopathy, dilated, 1BB?",
    "seeds": [
      "Cardiomyopathy, dilated, 1BB"
    ],
    "gold_answer": "Heart block",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00641",
    "question": "What is associated with Niemann-Pick disease type C?",
    "seeds": [
      "Niemann-Pick disease type C"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00642",
    "question": "What is associated with Nonexudative conjunctivitis?",
    "seeds": [
      "Nonexudative conjunctivitis"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00643",
    "question": "What is associated with Impaired ocular adduction?",
    "seeds": [
      "Impaired ocular adduction"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00644",
    "question": "What is associated with Metaphyseal chondromatosis of ulna?",
    "seeds": [
      "Metaphyseal chondromatosis of ulna"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00645",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 73?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 73"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00646",
    "question": "What is associated with Glycogen storage disease Ia?",
    "seeds": [
      "Glycogen storage disease Ia"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00647",
    "question": "What is associated with Toe clinodactyly?",
    "seeds": [
      "Toe clinodactyly"
    ],
    "gold_answer": "Deviation of toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00648",
    "question": "What is associated with Partial fusion of proximal row of carpal bones?",
    "seeds": [
      "Partial fusion of proximal row of carpal bones"
    ],
    "gold_answer": "Carpal synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00649",
    "question": "What is associated with Complete right bundle branch block?",
    "seeds": [
      "Complete right bundle branch block"
    ],
    "gold_answer": "Cardiac conduction abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00650",
    "question": "What is associated with Short 2nd toe?",
    "seeds": [
      "Short 2nd toe"
    ],
    "gold_answer": "Short toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00651",
    "question": "What is associated with EEG with generalized polyspikes?",
    "seeds": [
      "EEG with generalized polyspikes"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00652",
    "question": "What is associated with Broad hallux phalanx?",
    "seeds": [
      "Broad hallux phalanx"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00653",
    "question": "What is associated with Weak pulse?",
    "seeds": [
      "Weak pulse"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00654",
    "question": "What phenotype is associated with Amyotrophic lateral sclerosis, juvenile, with dementia?",
    "seeds": [
      "Amyotrophic lateral sclerosis, juvenile, with dementia"
    ],
    "gold_answer": "Upper limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00655",
    "question": "What phenotype is associated with Retinitis pigmentosa 26?",
    "seeds": [
      "Retinitis pigmentosa 26"
    ],
    "gold_answer": "Attenuation of retinal blood vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00656",
    "question": "What is associated with Ichthyosis-prematurity syndrome?",
    "seeds": [
      "Ichthyosis-prematurity syndrome"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00657",
    "question": "What is associated with Carbamazepine exposure?",
    "seeds": [
      "Carbamazepine exposure"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00658",
    "question": "What is associated with Granuloma?",
    "seeds": [
      "Granuloma"
    ],
    "gold_answer": "Abnormal immune system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00659",
    "question": "What is associated with Multiple unerupted teeth?",
    "seeds": [
      "Multiple unerupted teeth"
    ],
    "gold_answer": "Eruption failure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00660",
    "question": "What is associated with Elevated urine hydroxyphenyllactic acid level?",
    "seeds": [
      "Elevated urine hydroxyphenyllactic acid level"
    ],
    "gold_answer": "Increased urinary non-proteinogenic amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00661",
    "question": "What is associated with Two-raphe bicuspid aortic valve?",
    "seeds": [
      "Two-raphe bicuspid aortic valve"
    ],
    "gold_answer": "Abnormal aortic valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00662",
    "question": "What is associated with Renal glucosuria?",
    "seeds": [
      "Renal glucosuria"
    ],
    "gold_answer": "Abnormal consumption behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00663",
    "question": "What is associated with STXBP1-related encephalopathy?",
    "seeds": [
      "STXBP1-related encephalopathy"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00664",
    "question": "What is associated with Abnormal germ cell morphology?",
    "seeds": [
      "Abnormal germ cell morphology"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00665",
    "question": "What is associated with Typified by somatic mosaicism?",
    "seeds": [
      "Typified by somatic mosaicism"
    ],
    "gold_answer": "Mode of inheritance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00666",
    "question": "What is associated with Beemer lethal malformation syndrome?",
    "seeds": [
      "Beemer lethal malformation syndrome"
    ],
    "gold_answer": "Abnormal external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00667",
    "question": "What is associated with Radial nerve distribution?",
    "seeds": [
      "Radial nerve distribution"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00668",
    "question": "What is associated with Autosomal recessive cutis laxa type 2B?",
    "seeds": [
      "Autosomal recessive cutis laxa type 2B"
    ],
    "gold_answer": "PYCR1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_00669",
    "question": "What is associated with Diarrhea?",
    "seeds": [
      "Diarrhea"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00670",
    "question": "What is associated with Elevated urinary succinylaminoimidazole carboxamide riboside level?",
    "seeds": [
      "Elevated urinary succinylaminoimidazole carboxamide riboside level"
    ],
    "gold_answer": "Abnormal urinary purine level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00671",
    "question": "What is associated with Empty delta sign?",
    "seeds": [
      "Empty delta sign"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00672",
    "question": "What is associated with Confusion?",
    "seeds": [
      "Confusion"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00673",
    "question": "What is associated with Abnormal placental adhesion into the uterine wall?",
    "seeds": [
      "Abnormal placental adhesion into the uterine wall"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00674",
    "question": "What is associated with Premature fusion of phalangeal epiphyses?",
    "seeds": [
      "Premature fusion of phalangeal epiphyses"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00675",
    "question": "What is associated with Progressive conductive hearing impairment?",
    "seeds": [
      "Progressive conductive hearing impairment"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00676",
    "question": "What is associated with Peripheral motor neuropathy, childhood-onset, biotin-responsive?",
    "seeds": [
      "Peripheral motor neuropathy, childhood-onset, biotin-responsive"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00677",
    "question": "What is associated with Elevated circulating acetoacetic acid concentration?",
    "seeds": [
      "Elevated circulating acetoacetic acid concentration"
    ],
    "gold_answer": "Hyperketonemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00678",
    "question": "What is associated with Aspergillosis?",
    "seeds": [
      "Aspergillosis"
    ],
    "gold_answer": "Inflammatory abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00679",
    "question": "What is associated with Periosteal thickening of long tubular bones?",
    "seeds": [
      "Periosteal thickening of long tubular bones"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00680",
    "question": "What is associated with Abnormal lymph-node cellular B-cell marker expression?",
    "seeds": [
      "Abnormal lymph-node cellular B-cell marker expression"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00681",
    "question": "What is associated with Anti-GD1b IgG antibody positivity?",
    "seeds": [
      "Anti-GD1b IgG antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00682",
    "question": "What is associated with Myoclonic absence status epilepticus?",
    "seeds": [
      "Myoclonic absence status epilepticus"
    ],
    "gold_answer": "Status epilepticus without prominent motor symptoms",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00683",
    "question": "What is associated with Popliteal pterygium syndrome, Bartsocas-Papas type 2?",
    "seeds": [
      "Popliteal pterygium syndrome, Bartsocas-Papas type 2"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00684",
    "question": "What is associated with Reduced muscle fiber perlecan?",
    "seeds": [
      "Reduced muscle fiber perlecan"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00685",
    "question": "What is associated with Triggered by emotion?",
    "seeds": [
      "Triggered by emotion"
    ],
    "gold_answer": "Triggered by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00686",
    "question": "What phenotype is associated with Intellectual disability-cataracts-calcified pinnae-myopathy syndrome?",
    "seeds": [
      "Intellectual disability-cataracts-calcified pinnae-myopathy syndrome"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00687",
    "question": "What is associated with Neurodevelopmental disorder with early-onset parkinsonism and behavioral abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with early-onset parkinsonism and behavioral abnormalities"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00688",
    "question": "What is associated with Slow-growing hair?",
    "seeds": [
      "Slow-growing hair"
    ],
    "gold_answer": "Abnormality of hair growth rate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00689",
    "question": "What is associated with Autoimmune lymphoproliferative syndrome, type V?",
    "seeds": [
      "Autoimmune lymphoproliferative syndrome, type V"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00690",
    "question": "What is associated with Hematochezia?",
    "seeds": [
      "Hematochezia"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00691",
    "question": "What phenotype is associated with Craniosynostosis and dental anomalies?",
    "seeds": [
      "Craniosynostosis and dental anomalies"
    ],
    "gold_answer": "Sagittal craniosynostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00692",
    "question": "What phenotype is associated with Brachydactyly type B?",
    "seeds": [
      "Brachydactyly type B"
    ],
    "gold_answer": "Symphalangism affecting the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00693",
    "question": "What is associated with Ivory epiphysis of the distal phalanx of the 4th finger?",
    "seeds": [
      "Ivory epiphysis of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00694",
    "question": "What is associated with Myasthenic syndrome, congenital, 24, presynaptic?",
    "seeds": [
      "Myasthenic syndrome, congenital, 24, presynaptic"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00695",
    "question": "What phenotype is associated with Spastic paraplegia 56, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 56, autosomal recessive"
    ],
    "gold_answer": "Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00696",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanges of the hand?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00697",
    "question": "What is associated with Complement component 4A deficiency?",
    "seeds": [
      "Complement component 4A deficiency"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00698",
    "question": "What is associated with Focal aware cognitive seizure with receptive dysphasia/aphasia?",
    "seeds": [
      "Focal aware cognitive seizure with receptive dysphasia/aphasia"
    ],
    "gold_answer": "Focal aware seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00699",
    "question": "What is associated with Reduced muscle phosphoglycerate mutase activity?",
    "seeds": [
      "Reduced muscle phosphoglycerate mutase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00700",
    "question": "What is associated with Absence of the pulmonary artery?",
    "seeds": [
      "Absence of the pulmonary artery"
    ],
    "gold_answer": "Abnormal heart sound",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00701",
    "question": "What is associated with Pulmonary lymphoma?",
    "seeds": [
      "Pulmonary lymphoma"
    ],
    "gold_answer": "Neoplasm of the lung",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00702",
    "question": "What is associated with Abnormal aortic morphology?",
    "seeds": [
      "Abnormal aortic morphology"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00703",
    "question": "What is associated with Cold-sensitive myotonia?",
    "seeds": [
      "Cold-sensitive myotonia"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00704",
    "question": "What phenotype is associated with Coenzyme Q10 deficiency, primary, 9?",
    "seeds": [
      "Coenzyme Q10 deficiency, primary, 9"
    ],
    "gold_answer": "Encephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00705",
    "question": "What is associated with Osteolytic defects of the middle phalanges of the toes?",
    "seeds": [
      "Osteolytic defects of the middle phalanges of the toes"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00706",
    "question": "What is associated with Increased circulating IgG4 level?",
    "seeds": [
      "Increased circulating IgG4 level"
    ],
    "gold_answer": "Increased circulating IgG subclass",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00707",
    "question": "What is associated with Sertoli cell hypoplasia?",
    "seeds": [
      "Sertoli cell hypoplasia"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00708",
    "question": "What is associated with Gordon syndrome?",
    "seeds": [
      "Gordon syndrome"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00709",
    "question": "What is associated with Increased CSF threonine concentration?",
    "seeds": [
      "Increased CSF threonine concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00710",
    "question": "What is associated with Ventricular preexcitation?",
    "seeds": [
      "Ventricular preexcitation"
    ],
    "gold_answer": "Ventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00711",
    "question": "What is associated with Classic glucose transporter type 1 deficiency syndrome?",
    "seeds": [
      "Classic glucose transporter type 1 deficiency syndrome"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00712",
    "question": "What is associated with Cone-Rod dystrophy, X-linked, 3?",
    "seeds": [
      "Cone-Rod dystrophy, X-linked, 3"
    ],
    "gold_answer": "Abnormal full-field electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00713",
    "question": "What is associated with Fractured metatarsal bone of digit 1?",
    "seeds": [
      "Fractured metatarsal bone of digit 1"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00714",
    "question": "What is associated with Erythroderma?",
    "seeds": [
      "Erythroderma"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00715",
    "question": "What is associated with Triangular shaped proximal phalanx of the 2nd finger?",
    "seeds": [
      "Triangular shaped proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormal 2nd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00716",
    "question": "What is associated with Cortical nephrocalcinosis?",
    "seeds": [
      "Cortical nephrocalcinosis"
    ],
    "gold_answer": "Nephrocalcinosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00717",
    "question": "What is associated with Abnormal B cell morphology?",
    "seeds": [
      "Abnormal B cell morphology"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00718",
    "question": "What phenotype is associated with Aplasia cutis-enamel dysplasia syndrome?",
    "seeds": [
      "Aplasia cutis-enamel dysplasia syndrome"
    ],
    "gold_answer": "Erythema",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00719",
    "question": "What phenotype is associated with Immunodeficiency, common variable, 7?",
    "seeds": [
      "Immunodeficiency, common variable, 7"
    ],
    "gold_answer": "Decreased circulating IgA concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00720",
    "question": "What is associated with Localized hirsutism?",
    "seeds": [
      "Localized hirsutism"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00721",
    "question": "What is associated with Tibial tubercle apophysitis?",
    "seeds": [
      "Tibial tubercle apophysitis"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00722",
    "question": "What is associated with Achromatopsia 2?",
    "seeds": [
      "Achromatopsia 2"
    ],
    "gold_answer": "PDE6C",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00723",
    "question": "What is associated with Maxillary lateral incisor microdontia?",
    "seeds": [
      "Maxillary lateral incisor microdontia"
    ],
    "gold_answer": "Microdontia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00724",
    "question": "What is associated with Abnormal Esterman grid perimetry test?",
    "seeds": [
      "Abnormal Esterman grid perimetry test"
    ],
    "gold_answer": "Abnormal static automated perimetry test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00725",
    "question": "What is associated with Familial adenomatous polyposis 4?",
    "seeds": [
      "Familial adenomatous polyposis 4"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00726",
    "question": "What is associated with Comma-shaped carpal bones?",
    "seeds": [
      "Comma-shaped carpal bones"
    ],
    "gold_answer": "Abnormally shaped carpal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00727",
    "question": "What is associated with Aplasia/Hypoplasia of the biceps?",
    "seeds": [
      "Aplasia/Hypoplasia of the biceps"
    ],
    "gold_answer": "Abnormality of the upper arm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00728",
    "question": "What is associated with Elevated circulating C-terminal fibroblast growth factor 23 concentration?",
    "seeds": [
      "Elevated circulating C-terminal fibroblast growth factor 23 concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00729",
    "question": "What is associated with Abnormal hemoglobin?",
    "seeds": [
      "Abnormal hemoglobin"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00730",
    "question": "What is associated with Dermal microfilaria?",
    "seeds": [
      "Dermal microfilaria"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00731",
    "question": "What is associated with Anterior radial head dislocation?",
    "seeds": [
      "Anterior radial head dislocation"
    ],
    "gold_answer": "Upper extremity joint dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00732",
    "question": "What is associated with Topographical agnosia?",
    "seeds": [
      "Topographical agnosia"
    ],
    "gold_answer": "Abnormal interpretation of external stimuli",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00733",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 36?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 36"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00734",
    "question": "What is associated with Oligoclonal elevation of circulating IgM?",
    "seeds": [
      "Oligoclonal elevation of circulating IgM"
    ],
    "gold_answer": "Abnormal circulating IgM concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00735",
    "question": "What phenotype is associated with Carbamoyl phosphate synthetase I deficiency, hyperammonemia due to?",
    "seeds": [
      "Carbamoyl phosphate synthetase I deficiency, hyperammonemia due to"
    ],
    "gold_answer": "Lethargy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00736",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 51?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 51"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00737",
    "question": "What phenotype is associated with Thyrotoxic periodic paralysis, susceptibility to, 1?",
    "seeds": [
      "Thyrotoxic periodic paralysis, susceptibility to, 1"
    ],
    "gold_answer": "Rhabdomyolysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00738",
    "question": "What is associated with Midline facial cleft?",
    "seeds": [
      "Midline facial cleft"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00739",
    "question": "What is associated with Polyarticular arthropathy?",
    "seeds": [
      "Polyarticular arthropathy"
    ],
    "gold_answer": "Arthropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00740",
    "question": "What is associated with Nonepidermolytic palmoplantar hyperkeratosis?",
    "seeds": [
      "Nonepidermolytic palmoplantar hyperkeratosis"
    ],
    "gold_answer": "Palmoplantar hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00741",
    "question": "What phenotype is associated with Chronic intestinal pseudoobstruction syndrome?",
    "seeds": [
      "Chronic intestinal pseudoobstruction syndrome"
    ],
    "gold_answer": "Patent ductus arteriosus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00742",
    "question": "What phenotype is associated with Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4A?",
    "seeds": [
      "Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4A"
    ],
    "gold_answer": "Hyperammonemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00743",
    "question": "What is associated with Limited shoulder internal rotation?",
    "seeds": [
      "Limited shoulder internal rotation"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00744",
    "question": "What is associated with Angiolipomatosis, familial?",
    "seeds": [
      "Angiolipomatosis, familial"
    ],
    "gold_answer": "Lipomatous tumor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00745",
    "question": "What is associated with 46,XX difference of sex development-skeletal anomalies syndrome?",
    "seeds": [
      "46,XX difference of sex development-skeletal anomalies syndrome"
    ],
    "gold_answer": "Abnormal size of the clitoris",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00746",
    "question": "What is associated with Internal notch of the femoral head?",
    "seeds": [
      "Internal notch of the femoral head"
    ],
    "gold_answer": "Abnormal femoral head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00747",
    "question": "What is associated with Abnormal protein O-linked glycosylation?",
    "seeds": [
      "Abnormal protein O-linked glycosylation"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00748",
    "question": "What phenotype is associated with Macrocephaly, dysmorphic facies, and psychomotor retardation?",
    "seeds": [
      "Macrocephaly, dysmorphic facies, and psychomotor retardation"
    ],
    "gold_answer": "Low-set ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00749",
    "question": "What is associated with Abnormal tibia morphology?",
    "seeds": [
      "Abnormal tibia morphology"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00750",
    "question": "What is associated with Patent ductus arteriosus after birth at term?",
    "seeds": [
      "Patent ductus arteriosus after birth at term"
    ],
    "gold_answer": "Patent ductus arteriosus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00751",
    "question": "What is associated with Infantile spasms-broad thumbs syndrome?",
    "seeds": [
      "Infantile spasms-broad thumbs syndrome"
    ],
    "gold_answer": "Abnormal corpus callosum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00752",
    "question": "What phenotype is associated with Zygomycosis?",
    "seeds": [
      "Zygomycosis"
    ],
    "gold_answer": "Retinal detachment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00753",
    "question": "What is associated with Broad lateral eyebrow?",
    "seeds": [
      "Broad lateral eyebrow"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00754",
    "question": "What is associated with Focal impaired awareness autonomic seizure with erection?",
    "seeds": [
      "Focal impaired awareness autonomic seizure with erection"
    ],
    "gold_answer": "Focal impaired awareness autonomic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00755",
    "question": "What is associated with Laryngeal hemangioma?",
    "seeds": [
      "Laryngeal hemangioma"
    ],
    "gold_answer": "Hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00756",
    "question": "What phenotype is associated with Hatipoglu immunodeficiency syndrome?",
    "seeds": [
      "Hatipoglu immunodeficiency syndrome"
    ],
    "gold_answer": "Autistic behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00757",
    "question": "What is associated with Triggered by EBV infection?",
    "seeds": [
      "Triggered by EBV infection"
    ],
    "gold_answer": "Triggered by infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00758",
    "question": "What phenotype is associated with Intellectual disability-cardiac anomalies-short stature-joint laxity syndrome?",
    "seeds": [
      "Intellectual disability-cardiac anomalies-short stature-joint laxity syndrome"
    ],
    "gold_answer": "Talipes equinovarus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00759",
    "question": "What is associated with Intrauterine fetal demise of one twin after midgestation?",
    "seeds": [
      "Intrauterine fetal demise of one twin after midgestation"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00760",
    "question": "What is associated with MODY?",
    "seeds": [
      "MODY"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00761",
    "question": "What phenotype is associated with Spondylometaphyseal dysplasia, Megarbane-Dagher-Melki type?",
    "seeds": [
      "Spondylometaphyseal dysplasia, Megarbane-Dagher-Melki type"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00762",
    "question": "What is associated with Malaise?",
    "seeds": [
      "Malaise"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00763",
    "question": "What is associated with Orofaciodigital syndrome type 14?",
    "seeds": [
      "Orofaciodigital syndrome type 14"
    ],
    "gold_answer": "Neoplasm of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00764",
    "question": "What is associated with Ovarian cyst?",
    "seeds": [
      "Ovarian cyst"
    ],
    "gold_answer": "Abnormality of the ovary",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00765",
    "question": "What phenotype is associated with Common arterial trunk?",
    "seeds": [
      "Common arterial trunk"
    ],
    "gold_answer": "Broad forehead",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00766",
    "question": "What is associated with Anti-acetylcholine receptor antibody positivity?",
    "seeds": [
      "Anti-acetylcholine receptor antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00767",
    "question": "What is associated with Abnormal base excess?",
    "seeds": [
      "Abnormal base excess"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00768",
    "question": "What is associated with Abnormal humeral metaphysis morphology?",
    "seeds": [
      "Abnormal humeral metaphysis morphology"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00769",
    "question": "What is associated with Holoprosencephaly 1?",
    "seeds": [
      "Holoprosencephaly 1"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00770",
    "question": "What is associated with Recurrent meningococcal disease?",
    "seeds": [
      "Recurrent meningococcal disease"
    ],
    "gold_answer": "Recurrent gram-negative bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00771",
    "question": "What is associated with Abnormal liver parenchyma morphology?",
    "seeds": [
      "Abnormal liver parenchyma morphology"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00772",
    "question": "What is associated with Shallow anterior chamber?",
    "seeds": [
      "Shallow anterior chamber"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00773",
    "question": "What is associated with Microcephaly-corpus callosum hypoplasia-intellectual disability-facial dysmorphism syndrome?",
    "seeds": [
      "Microcephaly-corpus callosum hypoplasia-intellectual disability-facial dysmorphism syndrome"
    ],
    "gold_answer": "Abdominal wall defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00774",
    "question": "What is associated with Enlarged interphalangeal joints?",
    "seeds": [
      "Enlarged interphalangeal joints"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00775",
    "question": "What is associated with Abnormal jaw morphology?",
    "seeds": [
      "Abnormal jaw morphology"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00776",
    "question": "What is associated with Late onset?",
    "seeds": [
      "Late onset"
    ],
    "gold_answer": "Onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00777",
    "question": "What is associated with Clinodactyly of the 2nd finger?",
    "seeds": [
      "Clinodactyly of the 2nd finger"
    ],
    "gold_answer": "Deviation of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00778",
    "question": "What phenotype is associated with Autosomal recessive cutis laxa type 2, classic type?",
    "seeds": [
      "Autosomal recessive cutis laxa type 2, classic type"
    ],
    "gold_answer": "Dementia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00779",
    "question": "What is associated with Erythrocytosis, familial, 8?",
    "seeds": [
      "Erythrocytosis, familial, 8"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00780",
    "question": "What is associated with Decreased circulating IgG3 concentration?",
    "seeds": [
      "Decreased circulating IgG3 concentration"
    ],
    "gold_answer": "Abnormal circulating IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00781",
    "question": "What is associated with Colorectal cancer, hereditary nonpolyposis, type 2?",
    "seeds": [
      "Colorectal cancer, hereditary nonpolyposis, type 2"
    ],
    "gold_answer": "Neoplasm of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00782",
    "question": "What is associated with Stippling of the epiphysis of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Stippling of the epiphysis of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Epiphyseal stippling of toe phalanges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00783",
    "question": "What is associated with Renal dysplasia, cystic, susceptibility to?",
    "seeds": [
      "Renal dysplasia, cystic, susceptibility to"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00784",
    "question": "What is associated with Palpable thrill on extremity?",
    "seeds": [
      "Palpable thrill on extremity"
    ],
    "gold_answer": "Abnormal arterial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00785",
    "question": "What is associated with Pigmented paravenous retinochoroidal atrophy?",
    "seeds": [
      "Pigmented paravenous retinochoroidal atrophy"
    ],
    "gold_answer": "CRB1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00786",
    "question": "What is associated with Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive?",
    "seeds": [
      "Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive"
    ],
    "gold_answer": "Abnormal nonverbal communicative behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00787",
    "question": "What is associated with Congenital malformation of the great arteries?",
    "seeds": [
      "Congenital malformation of the great arteries"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00788",
    "question": "What is associated with Reduced tissue UDP-glucuronyl-transferase activity?",
    "seeds": [
      "Reduced tissue UDP-glucuronyl-transferase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00789",
    "question": "What phenotype is associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome?",
    "seeds": [
      "Megacystis-microcolon-intestinal hypoperistalsis syndrome"
    ],
    "gold_answer": "Elevated maternal circulating alpha-fetoprotein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00790",
    "question": "What phenotype is associated with Immunodeficiency 23?",
    "seeds": [
      "Immunodeficiency 23"
    ],
    "gold_answer": "Immunodeficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00791",
    "question": "What phenotype is associated with Acyl-Coa dehydrogenase, medium-chain, deficiency of?",
    "seeds": [
      "Acyl-Coa dehydrogenase, medium-chain, deficiency of"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00792",
    "question": "What is associated with Enlarged epiphysis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Enlarged epiphysis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00793",
    "question": "What is associated with Duplication of distal phalanx of toe?",
    "seeds": [
      "Duplication of distal phalanx of toe"
    ],
    "gold_answer": "Abnormal distal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00794",
    "question": "What is associated with Chondritis?",
    "seeds": [
      "Chondritis"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00795",
    "question": "What is associated with Very long-chain acyl-CoA dehydrogenase deficiency?",
    "seeds": [
      "Very long-chain acyl-CoA dehydrogenase deficiency"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00796",
    "question": "What is associated with Palmoplantar keratoderma-deafness syndrome?",
    "seeds": [
      "Palmoplantar keratoderma-deafness syndrome"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00797",
    "question": "What is associated with Abnormality of molar?",
    "seeds": [
      "Abnormality of molar"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00798",
    "question": "What phenotype is associated with Vertebral hypoplasia with lumbar kyphosis?",
    "seeds": [
      "Vertebral hypoplasia with lumbar kyphosis"
    ],
    "gold_answer": "Lumbar kyphosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00799",
    "question": "What is associated with Mitochondrial myopathy with lactic acidosis?",
    "seeds": [
      "Mitochondrial myopathy with lactic acidosis"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00800",
    "question": "What is associated with Cor pulmonale?",
    "seeds": [
      "Cor pulmonale"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00801",
    "question": "What phenotype is associated with Menke-Hennekam syndrome 2?",
    "seeds": [
      "Menke-Hennekam syndrome 2"
    ],
    "gold_answer": "Full cheeks",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00802",
    "question": "What phenotype is associated with Free sialic acid storage disease?",
    "seeds": [
      "Free sialic acid storage disease"
    ],
    "gold_answer": "Hydrops fetalis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00803",
    "question": "What is associated with Intellectual developmental disorder, X-linked 53?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 53"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00804",
    "question": "What is associated with Mucin casts?",
    "seeds": [
      "Mucin casts"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00805",
    "question": "What is associated with Abnormal cochlea morphology?",
    "seeds": [
      "Abnormal cochlea morphology"
    ],
    "gold_answer": "Abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00806",
    "question": "What is associated with Increased pituitary glycoprotein hormone alpha subunit level?",
    "seeds": [
      "Increased pituitary glycoprotein hormone alpha subunit level"
    ],
    "gold_answer": "Abnormal pituitary glycoprotein hormone alpha subunit level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00807",
    "question": "What is associated with Abnormal vomer morphology?",
    "seeds": [
      "Abnormal vomer morphology"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00808",
    "question": "What is associated with Ganglioglioma?",
    "seeds": [
      "Ganglioglioma"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00809",
    "question": "What is associated with Sclerosis of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Sclerosis of foot bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00810",
    "question": "What phenotype is associated with Appendicitis, proneness to?",
    "seeds": [
      "Appendicitis, proneness to"
    ],
    "gold_answer": "Abnormal large intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00811",
    "question": "What is associated with Hypoplasia of the fovea?",
    "seeds": [
      "Hypoplasia of the fovea"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00812",
    "question": "What is associated with Optically empty vitreous?",
    "seeds": [
      "Optically empty vitreous"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00813",
    "question": "What is associated with Intermediate collagen VI-related muscular dystrophy?",
    "seeds": [
      "Intermediate collagen VI-related muscular dystrophy"
    ],
    "gold_answer": "COL6A2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00814",
    "question": "What is associated with Rib spur?",
    "seeds": [
      "Rib spur"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00815",
    "question": "What is associated with Aberrant melanosome maturation?",
    "seeds": [
      "Aberrant melanosome maturation"
    ],
    "gold_answer": "Abnormality of dermal melanosomes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00816",
    "question": "What is associated with Tongue telangiectasia?",
    "seeds": [
      "Tongue telangiectasia"
    ],
    "gold_answer": "Abnormality of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00817",
    "question": "What is associated with Fatigable weakness of skeletal muscles?",
    "seeds": [
      "Fatigable weakness of skeletal muscles"
    ],
    "gold_answer": "Fatigable weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00818",
    "question": "What is associated with Reversible airflow obstruction?",
    "seeds": [
      "Reversible airflow obstruction"
    ],
    "gold_answer": "Airway obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00819",
    "question": "What is associated with Swiss cheese atrial septal defect?",
    "seeds": [
      "Swiss cheese atrial septal defect"
    ],
    "gold_answer": "Atrial septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00820",
    "question": "What is associated with History of gastric bypass surgery?",
    "seeds": [
      "History of gastric bypass surgery"
    ],
    "gold_answer": "Past surgical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00821",
    "question": "What is associated with Onset?",
    "seeds": [
      "Onset"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00822",
    "question": "What is associated with Fluctuating?",
    "seeds": [
      "Fluctuating"
    ],
    "gold_answer": "Clinical course",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00823",
    "question": "What is associated with Anterior chamber inflammatory cells?",
    "seeds": [
      "Anterior chamber inflammatory cells"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00824",
    "question": "What is associated with Pustular rash?",
    "seeds": [
      "Pustular rash"
    ],
    "gold_answer": "Skin rash",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00825",
    "question": "What phenotype is associated with X small rings syndrome?",
    "seeds": [
      "X small rings syndrome"
    ],
    "gold_answer": "Nyctalopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00826",
    "question": "What phenotype is associated with 19q13.11 microdeletion syndrome?",
    "seeds": [
      "19q13.11 microdeletion syndrome"
    ],
    "gold_answer": "Failure to thrive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00827",
    "question": "What is associated with Typified by age-related disease onset?",
    "seeds": [
      "Typified by age-related disease onset"
    ],
    "gold_answer": "Mode of inheritance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00828",
    "question": "What is associated with Abnormal atrial septum morphology?",
    "seeds": [
      "Abnormal atrial septum morphology"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00829",
    "question": "What is associated with Hypoplastic toenails?",
    "seeds": [
      "Hypoplastic toenails"
    ],
    "gold_answer": "Abnormal toenail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00830",
    "question": "What is associated with Cole-Carpenter syndrome?",
    "seeds": [
      "Cole-Carpenter syndrome"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00831",
    "question": "What is associated with Gonadal hypoplasia?",
    "seeds": [
      "Gonadal hypoplasia"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00832",
    "question": "What is associated with 6-mercaptopurine exposure?",
    "seeds": [
      "6-mercaptopurine exposure"
    ],
    "gold_answer": "Medication history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00833",
    "question": "What phenotype is associated with PANDAS?",
    "seeds": [
      "PANDAS"
    ],
    "gold_answer": "Impulsivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00834",
    "question": "What is associated with Positive bloodstream parainfluenza virus nucleic acid test?",
    "seeds": [
      "Positive bloodstream parainfluenza virus nucleic acid test"
    ],
    "gold_answer": "Positive bloodstream nucleic acid pathogen test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00835",
    "question": "What is associated with Recurrent viral infections?",
    "seeds": [
      "Recurrent viral infections"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00836",
    "question": "What is associated with Episodic pain syndrome, familial, 2?",
    "seeds": [
      "Episodic pain syndrome, familial, 2"
    ],
    "gold_answer": "Abnormality of pain sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00837",
    "question": "What is associated with Botulism?",
    "seeds": [
      "Botulism"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00838",
    "question": "What is associated with Elevated fecal sodium?",
    "seeds": [
      "Elevated fecal sodium"
    ],
    "gold_answer": "Abnormal digestive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00839",
    "question": "What is associated with Macular pseudocoloboma?",
    "seeds": [
      "Macular pseudocoloboma"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00840",
    "question": "What is associated with Dermatan sulfate excretion in urine?",
    "seeds": [
      "Dermatan sulfate excretion in urine"
    ],
    "gold_answer": "Mucopolysacchariduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00841",
    "question": "What phenotype is associated with Ankyloglossia with or without tooth anomalies?",
    "seeds": [
      "Ankyloglossia with or without tooth anomalies"
    ],
    "gold_answer": "Ankyloglossia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00842",
    "question": "What is associated with Multiple epiphyseal dysplasia, Lowry type?",
    "seeds": [
      "Multiple epiphyseal dysplasia, Lowry type"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00843",
    "question": "What is associated with Bleeding disorder in hemophilia A carriers?",
    "seeds": [
      "Bleeding disorder in hemophilia A carriers"
    ],
    "gold_answer": "Abnormal female reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00844",
    "question": "What phenotype is associated with Multiple self-healing squamous epithelioma, susceptibility to?",
    "seeds": [
      "Multiple self-healing squamous epithelioma, susceptibility to"
    ],
    "gold_answer": "Self-healing squamous epithelioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00845",
    "question": "What is associated with Blue cone monochromatism?",
    "seeds": [
      "Blue cone monochromatism"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00846",
    "question": "What is associated with Retroperitoneal paraganglioma?",
    "seeds": [
      "Retroperitoneal paraganglioma"
    ],
    "gold_answer": "Neoplasm of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00847",
    "question": "What is associated with Distal 2nd toe symphalangism?",
    "seeds": [
      "Distal 2nd toe symphalangism"
    ],
    "gold_answer": "Toe phalanx synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00848",
    "question": "What is associated with Hyperoxemia?",
    "seeds": [
      "Hyperoxemia"
    ],
    "gold_answer": "Abnormal blood oxygen level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00849",
    "question": "What is associated with Chronic active Epstein-Barr virus infection?",
    "seeds": [
      "Chronic active Epstein-Barr virus infection"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00850",
    "question": "What is associated with Bardet-Biedl syndrome 7?",
    "seeds": [
      "Bardet-Biedl syndrome 7"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00851",
    "question": "What is associated with Bracket epiphysis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Bracket epiphysis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal 3rd finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00852",
    "question": "What is associated with Abnormal circulating alanine concentration?",
    "seeds": [
      "Abnormal circulating alanine concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid derivative concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00853",
    "question": "What is associated with Iliac artery aneurysm?",
    "seeds": [
      "Iliac artery aneurysm"
    ],
    "gold_answer": "Abnormal iliac artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00854",
    "question": "What is associated with Cylindromatosis, familial?",
    "seeds": [
      "Cylindromatosis, familial"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00855",
    "question": "What is associated with Clinical anophthalmos?",
    "seeds": [
      "Clinical anophthalmos"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00856",
    "question": "What is associated with Indifference to pain, congenital, autosomal recessive?",
    "seeds": [
      "Indifference to pain, congenital, autosomal recessive"
    ],
    "gold_answer": "Increased susceptibility to fractures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00857",
    "question": "What is associated with Focal aware seizure?",
    "seeds": [
      "Focal aware seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00858",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2EE?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2EE"
    ],
    "gold_answer": "EMG: neuropathic changes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00859",
    "question": "What is associated with Alzheimer disease 2?",
    "seeds": [
      "Alzheimer disease 2"
    ],
    "gold_answer": "Cerebral inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00860",
    "question": "What is associated with Retinitis pigmentosa 24?",
    "seeds": [
      "Retinitis pigmentosa 24"
    ],
    "gold_answer": "Retinal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00861",
    "question": "What is associated with Papillomatosis, familial cutaneous?",
    "seeds": [
      "Papillomatosis, familial cutaneous"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00862",
    "question": "What is associated with Autism spectrum disorder due to AUTS2 deficiency?",
    "seeds": [
      "Autism spectrum disorder due to AUTS2 deficiency"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00863",
    "question": "What is associated with Difficulty descending stairs?",
    "seeds": [
      "Difficulty descending stairs"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00864",
    "question": "What is associated with Abnormal 4th finger phalanx morphology?",
    "seeds": [
      "Abnormal 4th finger phalanx morphology"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00865",
    "question": "What is associated with Choroidal dystrophy, central areolar 2?",
    "seeds": [
      "Choroidal dystrophy, central areolar 2"
    ],
    "gold_answer": "Abnormal chorioretinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00866",
    "question": "What is associated with Reduced brain lactate level by MRS?",
    "seeds": [
      "Reduced brain lactate level by MRS"
    ],
    "gold_answer": "Abnormal metabolic brain imaging by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00867",
    "question": "What is associated with Generalized aminoaciduria?",
    "seeds": [
      "Generalized aminoaciduria"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00868",
    "question": "What phenotype is associated with Gaucher disease type 3?",
    "seeds": [
      "Gaucher disease type 3"
    ],
    "gold_answer": "Anodontia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00869",
    "question": "What is associated with Brain fog?",
    "seeds": [
      "Brain fog"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00870",
    "question": "What is associated with Anterior cortical cataract?",
    "seeds": [
      "Anterior cortical cataract"
    ],
    "gold_answer": "Zonular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00871",
    "question": "What is associated with Abnormality of pattern onset/offset visual evoked potentials?",
    "seeds": [
      "Abnormality of pattern onset/offset visual evoked potentials"
    ],
    "gold_answer": "Abnormality of pattern visual evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00872",
    "question": "What phenotype is associated with Holoprosencephaly 12 with or without pancreatic agenesis?",
    "seeds": [
      "Holoprosencephaly 12 with or without pancreatic agenesis"
    ],
    "gold_answer": "Hitchhiker thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00873",
    "question": "What is associated with Pemphigus vulgaris, familial?",
    "seeds": [
      "Pemphigus vulgaris, familial"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00874",
    "question": "What is associated with Arteriosclerosis?",
    "seeds": [
      "Arteriosclerosis"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00875",
    "question": "What is associated with Astereognosis?",
    "seeds": [
      "Astereognosis"
    ],
    "gold_answer": "Tactile agnosia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00876",
    "question": "What phenotype is associated with Immunodeficiency, X-linked, with deficiency of 115,000 dalton surfaceglycoprotein?",
    "seeds": [
      "Immunodeficiency, X-linked, with deficiency of 115,000 dalton surfaceglycoprotein"
    ],
    "gold_answer": "Recurrent viral infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00877",
    "question": "What is associated with Coronary artery spasm?",
    "seeds": [
      "Coronary artery spasm"
    ],
    "gold_answer": "Abnormal arterial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00878",
    "question": "What is associated with Reduced mitochondrial acetyl-CoA acetyltransferase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced mitochondrial acetyl-CoA acetyltransferase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00879",
    "question": "What is associated with Anti-GW182 antibody positivity?",
    "seeds": [
      "Anti-GW182 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00880",
    "question": "What is associated with Diaphragmatic weakness?",
    "seeds": [
      "Diaphragmatic weakness"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00881",
    "question": "What is associated with Lymphoproliferative syndrome 3?",
    "seeds": [
      "Lymphoproliferative syndrome 3"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00882",
    "question": "What is associated with Medial humerus epicondyle avulsion fracture?",
    "seeds": [
      "Medial humerus epicondyle avulsion fracture"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00883",
    "question": "What phenotype is associated with Immunodeficiency-110 with lymphoproliferation?",
    "seeds": [
      "Immunodeficiency-110 with lymphoproliferation"
    ],
    "gold_answer": "Immunodeficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00884",
    "question": "What is associated with Peripheral amyelination?",
    "seeds": [
      "Peripheral amyelination"
    ],
    "gold_answer": "Abnormal peripheral nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00885",
    "question": "What is associated with Holster sign?",
    "seeds": [
      "Holster sign"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00886",
    "question": "What is associated with Juvenile gastrointestinal polyposis?",
    "seeds": [
      "Juvenile gastrointestinal polyposis"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00887",
    "question": "What is associated with Myelodysplastic neoplasm with increased blasts?",
    "seeds": [
      "Myelodysplastic neoplasm with increased blasts"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00888",
    "question": "What is associated with Common carotid artery aneurysm?",
    "seeds": [
      "Common carotid artery aneurysm"
    ],
    "gold_answer": "Abnormal carotid artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00889",
    "question": "What is associated with Proprioceptive-induced seizure?",
    "seeds": [
      "Proprioceptive-induced seizure"
    ],
    "gold_answer": "Reflex seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00890",
    "question": "What is associated with Aplasia of posterior communicating artery?",
    "seeds": [
      "Aplasia of posterior communicating artery"
    ],
    "gold_answer": "Abnormal cerebral artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00891",
    "question": "What phenotype is associated with Microcephaly-brachydactyly-kyphoscoliosis syndrome?",
    "seeds": [
      "Microcephaly-brachydactyly-kyphoscoliosis syndrome"
    ],
    "gold_answer": "Low-set ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00892",
    "question": "What phenotype is associated with Candidiasis, familial, 8?",
    "seeds": [
      "Candidiasis, familial, 8"
    ],
    "gold_answer": "Chronic oral candidiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00893",
    "question": "What is associated with Dermatitis, atopic, susceptibility to, 2?",
    "seeds": [
      "Dermatitis, atopic, susceptibility to, 2"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00894",
    "question": "What is associated with Fractured bone of jaw?",
    "seeds": [
      "Fractured bone of jaw"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00895",
    "question": "What is associated with Pain insensitivity?",
    "seeds": [
      "Pain insensitivity"
    ],
    "gold_answer": "Abnormal exteroceptive sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00896",
    "question": "What is associated with Hypercoagulability?",
    "seeds": [
      "Hypercoagulability"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00897",
    "question": "What is associated with Congenital disorder of glycosylation, type It?",
    "seeds": [
      "Congenital disorder of glycosylation, type It"
    ],
    "gold_answer": "KDR",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_00898",
    "question": "What is associated with B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality?",
    "seeds": [
      "B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality"
    ],
    "gold_answer": "FOXP1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_00899",
    "question": "What is associated with Reduced insulin like growth factor binding protein acid labile subunit concentration?",
    "seeds": [
      "Reduced insulin like growth factor binding protein acid labile subunit concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00900",
    "question": "What phenotype is associated with Rhabdomyolysis, susceptibility to, 2?",
    "seeds": [
      "Rhabdomyolysis, susceptibility to, 2"
    ],
    "gold_answer": "Muscle hypertrophy of the lower extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00901",
    "question": "What phenotype is associated with Congenital disorder of glycosylation with defective fucosylation 2?",
    "seeds": [
      "Congenital disorder of glycosylation with defective fucosylation 2"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00902",
    "question": "What phenotype is associated with Spondylometaphyseal dysplasia, Kozlowski type?",
    "seeds": [
      "Spondylometaphyseal dysplasia, Kozlowski type"
    ],
    "gold_answer": "Genu varum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00903",
    "question": "What phenotype is associated with Achondrogenesis, type IB?",
    "seeds": [
      "Achondrogenesis, type IB"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00904",
    "question": "What is associated with Abnormal pupil shape?",
    "seeds": [
      "Abnormal pupil shape"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00905",
    "question": "What is associated with Malignant atrophic papulosis?",
    "seeds": [
      "Malignant atrophic papulosis"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00906",
    "question": "What is associated with Pseudoaneurysm?",
    "seeds": [
      "Pseudoaneurysm"
    ],
    "gold_answer": "Vascular dilatation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00907",
    "question": "What is associated with Capillary fragility?",
    "seeds": [
      "Capillary fragility"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00908",
    "question": "What is associated with Arthrogryposis, distal, type 5D?",
    "seeds": [
      "Arthrogryposis, distal, type 5D"
    ],
    "gold_answer": "Abnormality of mouth size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00909",
    "question": "What is associated with Cerebellar atrophy, developmental delay, and seizures?",
    "seeds": [
      "Cerebellar atrophy, developmental delay, and seizures"
    ],
    "gold_answer": "Abnormal nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00910",
    "question": "What phenotype is associated with Wormian bone-multiple fractures-dentinogenesis imperfecta-skeletal dysplasia?",
    "seeds": [
      "Wormian bone-multiple fractures-dentinogenesis imperfecta-skeletal dysplasia"
    ],
    "gold_answer": "Upper limb undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00911",
    "question": "What is associated with Elevated intracellular cystine?",
    "seeds": [
      "Elevated intracellular cystine"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00912",
    "question": "What is associated with Decreased Th17 T cell proportion?",
    "seeds": [
      "Decreased Th17 T cell proportion"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00913",
    "question": "What is associated with Intraluminal meconium calcification?",
    "seeds": [
      "Intraluminal meconium calcification"
    ],
    "gold_answer": "Abnormal fetal gastrointestinal system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00914",
    "question": "What is associated with Hypoplastic ischiopubic ramus?",
    "seeds": [
      "Hypoplastic ischiopubic ramus"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00915",
    "question": "What is associated with Shukla-Vernon syndrome?",
    "seeds": [
      "Shukla-Vernon syndrome"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00916",
    "question": "What is associated with Congenital cataract-severe neonatal hepatopathy-global developmental delay syndrome?",
    "seeds": [
      "Congenital cataract-severe neonatal hepatopathy-global developmental delay syndrome"
    ],
    "gold_answer": "CYP51A1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00917",
    "question": "What is associated with Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation"
    ],
    "gold_answer": "Abnormality of the hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00918",
    "question": "What is associated with Tibial deviation of toes?",
    "seeds": [
      "Tibial deviation of toes"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00919",
    "question": "What is associated with Delayed elbow epiphyseal ossification?",
    "seeds": [
      "Delayed elbow epiphyseal ossification"
    ],
    "gold_answer": "Delayed epiphyseal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00920",
    "question": "What is associated with Overfolding of the superior helices?",
    "seeds": [
      "Overfolding of the superior helices"
    ],
    "gold_answer": "Abnormal helix morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00921",
    "question": "What is associated with Retrognathia?",
    "seeds": [
      "Retrognathia"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00922",
    "question": "What is associated with Intervertebral space narrowing?",
    "seeds": [
      "Intervertebral space narrowing"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00923",
    "question": "What is associated with Anti-laminin gamma1 antibody positivity?",
    "seeds": [
      "Anti-laminin gamma1 antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00924",
    "question": "What is associated with Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency?",
    "seeds": [
      "Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency"
    ],
    "gold_answer": "Abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00925",
    "question": "What is associated with Decreased circulating iron concentration?",
    "seeds": [
      "Decreased circulating iron concentration"
    ],
    "gold_answer": "Abnormal circulating iron concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00926",
    "question": "What is associated with Purely bicuspid aortic valve?",
    "seeds": [
      "Purely bicuspid aortic valve"
    ],
    "gold_answer": "Abnormal aortic valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00927",
    "question": "What is associated with Pseudoepiphyses of the phalanges of the hand?",
    "seeds": [
      "Pseudoepiphyses of the phalanges of the hand"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00928",
    "question": "What is associated with Pigment gallstones?",
    "seeds": [
      "Pigment gallstones"
    ],
    "gold_answer": "Abnormal gallbladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00929",
    "question": "What is associated with Elevated circulating erythropoietin concentration?",
    "seeds": [
      "Elevated circulating erythropoietin concentration"
    ],
    "gold_answer": "Abnormal circulating erythropoietin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00930",
    "question": "What phenotype is associated with 12q14 microdeletion syndrome?",
    "seeds": [
      "12q14 microdeletion syndrome"
    ],
    "gold_answer": "Clinodactyly of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00931",
    "question": "What is associated with Absent germinal center tingible body macrophages?",
    "seeds": [
      "Absent germinal center tingible body macrophages"
    ],
    "gold_answer": "Abnormal lymph-node germinal center morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00932",
    "question": "What is associated with Thinning and bulging of the posterior fossa bones?",
    "seeds": [
      "Thinning and bulging of the posterior fossa bones"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00933",
    "question": "What is associated with Chronic granulomatous disease 2, autosomal recessive?",
    "seeds": [
      "Chronic granulomatous disease 2, autosomal recessive"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00934",
    "question": "What phenotype is associated with Metachromatic leukodystrophy, juvenile form?",
    "seeds": [
      "Metachromatic leukodystrophy, juvenile form"
    ],
    "gold_answer": "Vegetative state",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00935",
    "question": "What is associated with EEG with constitutional variants?",
    "seeds": [
      "EEG with constitutional variants"
    ],
    "gold_answer": "Abnormal nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00936",
    "question": "What is associated with Wide penis?",
    "seeds": [
      "Wide penis"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00937",
    "question": "What is associated with Dihydropteridine reductase deficiency?",
    "seeds": [
      "Dihydropteridine reductase deficiency"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00938",
    "question": "What is associated with Moderate oligozoospermia?",
    "seeds": [
      "Moderate oligozoospermia"
    ],
    "gold_answer": "Abnormal spermatogenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00939",
    "question": "What is associated with Abnormality of the lower limb?",
    "seeds": [
      "Abnormality of the lower limb"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00940",
    "question": "What phenotype is associated with ZTTK syndrome?",
    "seeds": [
      "ZTTK syndrome"
    ],
    "gold_answer": "Impaired visuospatial constructive cognition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00941",
    "question": "What phenotype is associated with Mitochondrial DNA depletion syndrome 4B (mngie type)?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 4B (mngie type)"
    ],
    "gold_answer": "Multiple mitochondrial DNA deletions",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00942",
    "question": "What is associated with Abnormal gonadotropin-releasing hormone concentration?",
    "seeds": [
      "Abnormal gonadotropin-releasing hormone concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00943",
    "question": "What is associated with Autosomal recessive complex spastic paraplegia due to Kennedy pathway dysfunction?",
    "seeds": [
      "Autosomal recessive complex spastic paraplegia due to Kennedy pathway dysfunction"
    ],
    "gold_answer": "Proportionate short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00944",
    "question": "What is associated with Joubert syndrome 39?",
    "seeds": [
      "Joubert syndrome 39"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebellum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00945",
    "question": "What is associated with Abnormal play?",
    "seeds": [
      "Abnormal play"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00946",
    "question": "What is associated with Muscular dystrophy, limb-girdle, autosomal recessive 23?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, autosomal recessive 23"
    ],
    "gold_answer": "Limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00947",
    "question": "What is associated with Triceps weakness?",
    "seeds": [
      "Triceps weakness"
    ],
    "gold_answer": "Proximal upper limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00948",
    "question": "What phenotype is associated with Hyperinsulinism due to HNF1A deficiency?",
    "seeds": [
      "Hyperinsulinism due to HNF1A deficiency"
    ],
    "gold_answer": "Syncope",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00949",
    "question": "What is associated with Knee joint effusion?",
    "seeds": [
      "Knee joint effusion"
    ],
    "gold_answer": "Abnormality of the knee",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00950",
    "question": "What is associated with Wide radioulnar joints?",
    "seeds": [
      "Wide radioulnar joints"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00951",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 49?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 49"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00952",
    "question": "What is associated with Abnormality of the sublingual glands?",
    "seeds": [
      "Abnormality of the sublingual glands"
    ],
    "gold_answer": "Abnormal salivary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00953",
    "question": "What is associated with Triangular shaped proximal phalanx of the 2nd toe?",
    "seeds": [
      "Triangular shaped proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00954",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 56?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 56"
    ],
    "gold_answer": "CYP2U1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_00955",
    "question": "What is associated with Fifth metacarpal with ulnar notch?",
    "seeds": [
      "Fifth metacarpal with ulnar notch"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00956",
    "question": "What is associated with Abnormal dendritic cell count?",
    "seeds": [
      "Abnormal dendritic cell count"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00957",
    "question": "What is associated with Dalen-Fuchs nodules?",
    "seeds": [
      "Dalen-Fuchs nodules"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00958",
    "question": "What phenotype is associated with CIDEC-related familial partial lipodystrophy?",
    "seeds": [
      "CIDEC-related familial partial lipodystrophy"
    ],
    "gold_answer": "Lipodystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00959",
    "question": "What phenotype is associated with Epidermolysis bullosa simplex, Dowling-Meara type?",
    "seeds": [
      "Epidermolysis bullosa simplex, Dowling-Meara type"
    ],
    "gold_answer": "Oral mucosal blisters",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00960",
    "question": "What is associated with Facial hypertrichosis?",
    "seeds": [
      "Facial hypertrichosis"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00961",
    "question": "What is associated with Full cheeks?",
    "seeds": [
      "Full cheeks"
    ],
    "gold_answer": "Abnormal cheek morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00962",
    "question": "What is associated with 1-2 toe syndactyly?",
    "seeds": [
      "1-2 toe syndactyly"
    ],
    "gold_answer": "Syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00963",
    "question": "What is associated with Ingrown nail?",
    "seeds": [
      "Ingrown nail"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00964",
    "question": "What is associated with Partial duplication of the phalanges of the 4th finger?",
    "seeds": [
      "Partial duplication of the phalanges of the 4th finger"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00965",
    "question": "What is associated with Tetralogy of Fallot with atrioventricular canal defect?",
    "seeds": [
      "Tetralogy of Fallot with atrioventricular canal defect"
    ],
    "gold_answer": "Tetralogy of Fallot",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00966",
    "question": "What phenotype is associated with Microphthalmia, syndromic 3?",
    "seeds": [
      "Microphthalmia, syndromic 3"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00967",
    "question": "What is associated with Anti-MAP1B antibody?",
    "seeds": [
      "Anti-MAP1B antibody"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00968",
    "question": "What is associated with Atransferrinemia?",
    "seeds": [
      "Atransferrinemia"
    ],
    "gold_answer": "Abnormal circulating globulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00969",
    "question": "What is associated with Meckel diverticulum?",
    "seeds": [
      "Meckel diverticulum"
    ],
    "gold_answer": "Abnormal small intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00970",
    "question": "What is associated with Spinal muscular atrophy, distal, autosomal recessive, 1?",
    "seeds": [
      "Spinal muscular atrophy, distal, autosomal recessive, 1"
    ],
    "gold_answer": "Abnormality of peripheral nerve conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00971",
    "question": "What is associated with Onycholysis of fingernails?",
    "seeds": [
      "Onycholysis of fingernails"
    ],
    "gold_answer": "Onycholysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00972",
    "question": "What is associated with Abnormal hand metaphysis morphology?",
    "seeds": [
      "Abnormal hand metaphysis morphology"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00973",
    "question": "What is associated with Autosomal dominant Charcot-Marie-Tooth disease type 2Q?",
    "seeds": [
      "Autosomal dominant Charcot-Marie-Tooth disease type 2Q"
    ],
    "gold_answer": "DHTKD1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_00974",
    "question": "What is associated with Neonatal respiratory distress?",
    "seeds": [
      "Neonatal respiratory distress"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00975",
    "question": "What is associated with Sinus node disease and myopia?",
    "seeds": [
      "Sinus node disease and myopia"
    ],
    "gold_answer": "Myopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00976",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 69?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 69"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00977",
    "question": "What is associated with Microangiopathic hemolytic anemia?",
    "seeds": [
      "Microangiopathic hemolytic anemia"
    ],
    "gold_answer": "Hemolytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00978",
    "question": "What is associated with Abnormal full-field electroretinogram?",
    "seeds": [
      "Abnormal full-field electroretinogram"
    ],
    "gold_answer": "Abnormal electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00979",
    "question": "What is associated with Chorea, benign familial?",
    "seeds": [
      "Chorea, benign familial"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00980",
    "question": "What is associated with Nasal hamartoma?",
    "seeds": [
      "Nasal hamartoma"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00981",
    "question": "What is associated with Intramuscular lipoma?",
    "seeds": [
      "Intramuscular lipoma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00982",
    "question": "What phenotype is associated with Congenital labioscrotal agenesis-cerebellar malformation-corneal dystrophy-facial dysmorphism syndrome?",
    "seeds": [
      "Congenital labioscrotal agenesis-cerebellar malformation-corneal dystrophy-facial dysmorphism syndrome"
    ],
    "gold_answer": "Esophageal ulceration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00983",
    "question": "What is associated with Submucous cleft hard palate?",
    "seeds": [
      "Submucous cleft hard palate"
    ],
    "gold_answer": "Abnormal hard palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00984",
    "question": "What is associated with Glyoxalase deficiency?",
    "seeds": [
      "Glyoxalase deficiency"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00985",
    "question": "What is associated with Hyperinsulinemic hypoglycemia, familial, 3?",
    "seeds": [
      "Hyperinsulinemic hypoglycemia, familial, 3"
    ],
    "gold_answer": "Symptomatic seizures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00986",
    "question": "What is associated with ReNU syndrome?",
    "seeds": [
      "ReNU syndrome"
    ],
    "gold_answer": "Skeletal muscle hypertrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00987",
    "question": "What is associated with Diamond-Blackfan anemia 13?",
    "seeds": [
      "Diamond-Blackfan anemia 13"
    ],
    "gold_answer": "Abnormal erythrocyte enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00988",
    "question": "What is associated with Dyskinesia, seizures, and intellectual developmental disorder?",
    "seeds": [
      "Dyskinesia, seizures, and intellectual developmental disorder"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00989",
    "question": "What is associated with Renal interstitial calcium oxalate?",
    "seeds": [
      "Renal interstitial calcium oxalate"
    ],
    "gold_answer": "Calcium nephrolithiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00990",
    "question": "What is associated with Triangular epiphyses of the thumb?",
    "seeds": [
      "Triangular epiphyses of the thumb"
    ],
    "gold_answer": "Triangular epiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00991",
    "question": "What is associated with Early progressive calcific cardiac valvular disease?",
    "seeds": [
      "Early progressive calcific cardiac valvular disease"
    ],
    "gold_answer": "Cardiac valve calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00992",
    "question": "What is associated with Narrow joint spaces of wrist?",
    "seeds": [
      "Narrow joint spaces of wrist"
    ],
    "gold_answer": "Abnormality of the wrist",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00993",
    "question": "What is associated with Sertoli cell hypoplasia?",
    "seeds": [
      "Sertoli cell hypoplasia"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00994",
    "question": "What is associated with BLOOD GROUP--LUTHERAN INHIBITOR; INLU?",
    "seeds": [
      "BLOOD GROUP--LUTHERAN INHIBITOR; INLU"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00995",
    "question": "What is associated with Increased urinary non-proteinogenic amino acid level?",
    "seeds": [
      "Increased urinary non-proteinogenic amino acid level"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00996",
    "question": "What is associated with Elevated CSF 5-hydroxymethyluracil concentration?",
    "seeds": [
      "Elevated CSF 5-hydroxymethyluracil concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_00997",
    "question": "What is associated with Fetal akinesia deformation sequence?",
    "seeds": [
      "Fetal akinesia deformation sequence"
    ],
    "gold_answer": "KIF21A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_00998",
    "question": "What phenotype is associated with Anemia, nonspherocytic hemolytic, possibly due to defect in porphyrinmetabolism?",
    "seeds": [
      "Anemia, nonspherocytic hemolytic, possibly due to defect in porphyrinmetabolism"
    ],
    "gold_answer": "Jaundice",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_00999",
    "question": "What is associated with Ivory epiphyses of the middle phalanges of the hand?",
    "seeds": [
      "Ivory epiphyses of the middle phalanges of the hand"
    ],
    "gold_answer": "Ivory epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01000",
    "question": "What is associated with Fatigable weakness of speech muscles?",
    "seeds": [
      "Fatigable weakness of speech muscles"
    ],
    "gold_answer": "Abnormal synaptic transmission at the neuromuscular junction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01001",
    "question": "What is associated with Ambiguous genitalia, male?",
    "seeds": [
      "Ambiguous genitalia, male"
    ],
    "gold_answer": "Abnormal external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01002",
    "question": "What is associated with Tetra-Amelia with ectodermal dysplasia and lacrimal duct abnormalities?",
    "seeds": [
      "Tetra-Amelia with ectodermal dysplasia and lacrimal duct abnormalities"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01003",
    "question": "What is associated with Localized periodontitis?",
    "seeds": [
      "Localized periodontitis"
    ],
    "gold_answer": "Abnormality of the gingiva",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01004",
    "question": "What is associated with Enlarged semicircular canal?",
    "seeds": [
      "Enlarged semicircular canal"
    ],
    "gold_answer": "Abnormal semicircular canal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01005",
    "question": "What is associated with Femoral osteopoikilosis?",
    "seeds": [
      "Femoral osteopoikilosis"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01006",
    "question": "What is associated with Upper limb muscle hypertrophy?",
    "seeds": [
      "Upper limb muscle hypertrophy"
    ],
    "gold_answer": "Abnormality of muscle size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01007",
    "question": "What is associated with Peribronchovascular interstitial thickening?",
    "seeds": [
      "Peribronchovascular interstitial thickening"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01008",
    "question": "What is associated with Squamosal suture synostosis?",
    "seeds": [
      "Squamosal suture synostosis"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01009",
    "question": "What phenotype is associated with Placental insufficiency?",
    "seeds": [
      "Placental insufficiency"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01010",
    "question": "What is associated with Midline sinus of philtrum?",
    "seeds": [
      "Midline sinus of philtrum"
    ],
    "gold_answer": "Abnormal upper lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01011",
    "question": "What phenotype is associated with Deafness, autosomal dominant 81?",
    "seeds": [
      "Deafness, autosomal dominant 81"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01012",
    "question": "What is associated with Praxis-induced seizure?",
    "seeds": [
      "Praxis-induced seizure"
    ],
    "gold_answer": "Reflex seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01013",
    "question": "What is associated with Monoclonal elevation of intact IgG?",
    "seeds": [
      "Monoclonal elevation of intact IgG"
    ],
    "gold_answer": "Increased circulating IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01014",
    "question": "What is associated with LMNA-related congenital muscular dystrophy?",
    "seeds": [
      "LMNA-related congenital muscular dystrophy"
    ],
    "gold_answer": "Limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01015",
    "question": "What phenotype is associated with Spermatogenic failure 88?",
    "seeds": [
      "Spermatogenic failure 88"
    ],
    "gold_answer": "Spermatocyte maturation arrest",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01016",
    "question": "What is associated with Multiple mitochondrial DNA deletions?",
    "seeds": [
      "Multiple mitochondrial DNA deletions"
    ],
    "gold_answer": "Muscle abnormality related to mitochondrial dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01017",
    "question": "What is associated with Sclerosis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Sclerosis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Sclerosis of toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01018",
    "question": "What is associated with Neoplasm of the gallbladder?",
    "seeds": [
      "Neoplasm of the gallbladder"
    ],
    "gold_answer": "Abnormal gallbladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01019",
    "question": "What is associated with Vogt striae?",
    "seeds": [
      "Vogt striae"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01020",
    "question": "What phenotype is associated with Chromosome 10q26 deletion syndrome?",
    "seeds": [
      "Chromosome 10q26 deletion syndrome"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01021",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 7?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 7"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01022",
    "question": "What is associated with Elevated CSF cholestanol concentration?",
    "seeds": [
      "Elevated CSF cholestanol concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01023",
    "question": "What is associated with Chronic active Epstein-Barr virus infection?",
    "seeds": [
      "Chronic active Epstein-Barr virus infection"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01024",
    "question": "What is associated with Craniorachischisis?",
    "seeds": [
      "Craniorachischisis"
    ],
    "gold_answer": "Open neural tube defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01025",
    "question": "What is associated with Supernumerary tooth?",
    "seeds": [
      "Supernumerary tooth"
    ],
    "gold_answer": "Abnormal number of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01026",
    "question": "What is associated with Adrenal xanthomatosis?",
    "seeds": [
      "Adrenal xanthomatosis"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01027",
    "question": "What is associated with Retinal arterial macroaneurysm with supravalvular pulmonic stenosis?",
    "seeds": [
      "Retinal arterial macroaneurysm with supravalvular pulmonic stenosis"
    ],
    "gold_answer": "Abnormal pulmonary valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01028",
    "question": "What phenotype is associated with Hypoplastic left heart syndrome?",
    "seeds": [
      "Hypoplastic left heart syndrome"
    ],
    "gold_answer": "Coronaryartery atherosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01029",
    "question": "What is associated with SLC12A2-related autosomal dominant infantile-developmental delay-intellectual disability-sensorineural deafness syndrome?",
    "seeds": [
      "SLC12A2-related autosomal dominant infantile-developmental delay-intellectual disability-sensorineural deafness syndrome"
    ],
    "gold_answer": "SLC12A2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01030",
    "question": "What is associated with Elevated circulating 3-hydroxykynurenine concentration?",
    "seeds": [
      "Elevated circulating 3-hydroxykynurenine concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01031",
    "question": "What phenotype is associated with Hypercholanemia, familial?",
    "seeds": [
      "Hypercholanemia, familial"
    ],
    "gold_answer": "Pruritus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01032",
    "question": "What is associated with Elevated circulating methysterol concentration?",
    "seeds": [
      "Elevated circulating methysterol concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01033",
    "question": "What is associated with Internal carotid artery calcification?",
    "seeds": [
      "Internal carotid artery calcification"
    ],
    "gold_answer": "Carotid artery calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01034",
    "question": "What is associated with Infantile sensorineural hearing impairment?",
    "seeds": [
      "Infantile sensorineural hearing impairment"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01035",
    "question": "What is associated with Physiological reactivity to cues?",
    "seeds": [
      "Physiological reactivity to cues"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01036",
    "question": "What is associated with Post-capillary pulmonary hypertension?",
    "seeds": [
      "Post-capillary pulmonary hypertension"
    ],
    "gold_answer": "Abnormality of pulmonary circulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01037",
    "question": "What is associated with Sudden infant death-dysgenesis of the testes syndrome?",
    "seeds": [
      "Sudden infant death-dysgenesis of the testes syndrome"
    ],
    "gold_answer": "Sleep-related breathing disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01038",
    "question": "What is associated with Immunodeficiency 97 with autoinflammation?",
    "seeds": [
      "Immunodeficiency 97 with autoinflammation"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01039",
    "question": "What is associated with Abnormal cerebral cortex morphology?",
    "seeds": [
      "Abnormal cerebral cortex morphology"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01040",
    "question": "What is associated with Hypoplastic vertebral bodies?",
    "seeds": [
      "Hypoplastic vertebral bodies"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01041",
    "question": "What is associated with Functional abnormality of male internal genitalia?",
    "seeds": [
      "Functional abnormality of male internal genitalia"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01042",
    "question": "What phenotype is associated with Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes?",
    "seeds": [
      "Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes"
    ],
    "gold_answer": "Myopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01043",
    "question": "What phenotype is associated with ARTICHOKE, MODIFICATION OF TASTE BY?",
    "seeds": [
      "ARTICHOKE, MODIFICATION OF TASTE BY"
    ],
    "gold_answer": "Abnormality of taste sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01044",
    "question": "What is associated with Coalescence of tarsal bones?",
    "seeds": [
      "Coalescence of tarsal bones"
    ],
    "gold_answer": "Tarsal synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01045",
    "question": "What phenotype is associated with Night blindness, congenital stationary, type 1G?",
    "seeds": [
      "Night blindness, congenital stationary, type 1G"
    ],
    "gold_answer": "Rod-cone dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01046",
    "question": "What is associated with Increased red cell sickling tendency?",
    "seeds": [
      "Increased red cell sickling tendency"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01047",
    "question": "What is associated with Patchy sclerosis of the middle phalanx of the 5th toe?",
    "seeds": [
      "Patchy sclerosis of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Sclerosis of 5th toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01048",
    "question": "What is associated with Subcortical cerebral atrophy?",
    "seeds": [
      "Subcortical cerebral atrophy"
    ],
    "gold_answer": "Brain atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01049",
    "question": "What is associated with Choroidal dystrophy, central areolar 3?",
    "seeds": [
      "Choroidal dystrophy, central areolar 3"
    ],
    "gold_answer": "Yellow/white retinal lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01050",
    "question": "What is associated with Idiopathic catatonia?",
    "seeds": [
      "Idiopathic catatonia"
    ],
    "gold_answer": "Reduced consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01051",
    "question": "What is associated with Highly arched eyebrow?",
    "seeds": [
      "Highly arched eyebrow"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01052",
    "question": "What is associated with Elevated circulating cholesterol sulfate concentration?",
    "seeds": [
      "Elevated circulating cholesterol sulfate concentration"
    ],
    "gold_answer": "Abnormal circulating cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01053",
    "question": "What is associated with Stippled chondral calcification?",
    "seeds": [
      "Stippled chondral calcification"
    ],
    "gold_answer": "Abnormal cartilage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01054",
    "question": "What is associated with ELECTROENCEPHALOGRAPHIC PATTERNS?",
    "seeds": [
      "ELECTROENCEPHALOGRAPHIC PATTERNS"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01055",
    "question": "What is associated with Abnormality of neutrophils?",
    "seeds": [
      "Abnormality of neutrophils"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01056",
    "question": "What is associated with Positive bloodstream influenza nucleic test?",
    "seeds": [
      "Positive bloodstream influenza nucleic test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01057",
    "question": "What is associated with Spastic paraplegia 33, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 33, autosomal dominant"
    ],
    "gold_answer": "Abnormality of the ankle",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01058",
    "question": "What is associated with Deficit in nonword repetition?",
    "seeds": [
      "Deficit in nonword repetition"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01059",
    "question": "What is associated with Arcuate intimal/medial granulomatous venulitis?",
    "seeds": [
      "Arcuate intimal/medial granulomatous venulitis"
    ],
    "gold_answer": "Abnormal arcuate vein intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01060",
    "question": "What is associated with Branchiootorenal syndrome 1?",
    "seeds": [
      "Branchiootorenal syndrome 1"
    ],
    "gold_answer": "Abnormal seventh cranial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01061",
    "question": "What is associated with Ectopic posterior pituitary?",
    "seeds": [
      "Ectopic posterior pituitary"
    ],
    "gold_answer": "Abnormal posterior pituitary morphogenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01062",
    "question": "What is associated with Sensory exotropia?",
    "seeds": [
      "Sensory exotropia"
    ],
    "gold_answer": "Heterotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01063",
    "question": "What is associated with Severe norovirus infection?",
    "seeds": [
      "Severe norovirus infection"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01064",
    "question": "What is associated with Cone-shaped epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Cone-shaped epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Cone-shaped epiphyses of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01065",
    "question": "What is associated with Irregular sclerotic endplates?",
    "seeds": [
      "Irregular sclerotic endplates"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01066",
    "question": "What phenotype is associated with Bleeding disorder, platelet-type, 22?",
    "seeds": [
      "Bleeding disorder, platelet-type, 22"
    ],
    "gold_answer": "Thrombocytopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01067",
    "question": "What is associated with Focal facial dermal dysplasia type II?",
    "seeds": [
      "Focal facial dermal dysplasia type II"
    ],
    "gold_answer": "Ectropion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01068",
    "question": "What is associated with Elevated circulating myoglobin concentration?",
    "seeds": [
      "Elevated circulating myoglobin concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01069",
    "question": "What phenotype is associated with Warburg-Cinotti syndrome?",
    "seeds": [
      "Warburg-Cinotti syndrome"
    ],
    "gold_answer": "Wrist flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01070",
    "question": "What is associated with Descending thoracic aorta aneurysm?",
    "seeds": [
      "Descending thoracic aorta aneurysm"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01071",
    "question": "What is associated with Pseudoepiphysis of the distal phalanx of the 5th finger?",
    "seeds": [
      "Pseudoepiphysis of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the distal phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01072",
    "question": "What is associated with 2-methylbutyryl-CoA dehydrogenase deficiency?",
    "seeds": [
      "2-methylbutyryl-CoA dehydrogenase deficiency"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01073",
    "question": "What is associated with Abnormal placental membrane morphology?",
    "seeds": [
      "Abnormal placental membrane morphology"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01074",
    "question": "What is associated with Enlarged epiphyses of the 3rd finger?",
    "seeds": [
      "Enlarged epiphyses of the 3rd finger"
    ],
    "gold_answer": "Abnormal hand epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01075",
    "question": "What is associated with Diastrophic dysplasia?",
    "seeds": [
      "Diastrophic dysplasia"
    ],
    "gold_answer": "Upper extremity joint dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01076",
    "question": "What is associated with Usher syndrome, type IV?",
    "seeds": [
      "Usher syndrome, type IV"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01077",
    "question": "What is associated with Focal dermal aplasia/hypoplasia?",
    "seeds": [
      "Focal dermal aplasia/hypoplasia"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01078",
    "question": "What is associated with Dust mite allergy?",
    "seeds": [
      "Dust mite allergy"
    ],
    "gold_answer": "Allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01079",
    "question": "What is associated with Ectopic scrotum?",
    "seeds": [
      "Ectopic scrotum"
    ],
    "gold_answer": "Abnormal external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01080",
    "question": "What is associated with Abnormality of skin pigmentation?",
    "seeds": [
      "Abnormality of skin pigmentation"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01081",
    "question": "What is associated with Sparse medial eyebrow?",
    "seeds": [
      "Sparse medial eyebrow"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01082",
    "question": "What phenotype is associated with Pediatric systemic lupus erythematosus?",
    "seeds": [
      "Pediatric systemic lupus erythematosus"
    ],
    "gold_answer": "Antinuclear antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01083",
    "question": "What is associated with Abnormal posterior semicircular canal morphology?",
    "seeds": [
      "Abnormal posterior semicircular canal morphology"
    ],
    "gold_answer": "Abnormal semicircular canal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01084",
    "question": "What phenotype is associated with Posterior cortical atrophy?",
    "seeds": [
      "Posterior cortical atrophy"
    ],
    "gold_answer": "Abnormal rapid eye movement sleep",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01085",
    "question": "What is associated with Abnormal Bowman space morphology?",
    "seeds": [
      "Abnormal Bowman space morphology"
    ],
    "gold_answer": "Abnormal renal cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01086",
    "question": "What is associated with Cerebral cavernous malformations 2?",
    "seeds": [
      "Cerebral cavernous malformations 2"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01087",
    "question": "What is associated with Decreased CSF albumin concentration?",
    "seeds": [
      "Decreased CSF albumin concentration"
    ],
    "gold_answer": "Abnormal CSF protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01088",
    "question": "What phenotype is associated with Spermatogenic failure 74?",
    "seeds": [
      "Spermatogenic failure 74"
    ],
    "gold_answer": "Spermatogenesis maturation arrest",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01089",
    "question": "What is associated with Hepatic adenomas, familial?",
    "seeds": [
      "Hepatic adenomas, familial"
    ],
    "gold_answer": "Neoplasm of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01090",
    "question": "What is associated with Fructose intolerance?",
    "seeds": [
      "Fructose intolerance"
    ],
    "gold_answer": "Abnormal metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01091",
    "question": "What is associated with Calcification of joints and arteries?",
    "seeds": [
      "Calcification of joints and arteries"
    ],
    "gold_answer": "Ectopic calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01092",
    "question": "What is associated with Hypomature enamel?",
    "seeds": [
      "Hypomature enamel"
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01093",
    "question": "What phenotype is associated with Anonychia-Onychodystrophy with hypoplasia or absence of distal phalanges?",
    "seeds": [
      "Anonychia-Onychodystrophy with hypoplasia or absence of distal phalanges"
    ],
    "gold_answer": "Shortening of all distal phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01094",
    "question": "What is associated with Ameloblastoma?",
    "seeds": [
      "Ameloblastoma"
    ],
    "gold_answer": "Odontogenic neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01095",
    "question": "What is associated with Stiff interphalangeal joints?",
    "seeds": [
      "Stiff interphalangeal joints"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01096",
    "question": "What is associated with Optic atrophy 3, autosomal dominant?",
    "seeds": [
      "Optic atrophy 3, autosomal dominant"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01097",
    "question": "What is associated with Hernia, anterior diaphragmatic?",
    "seeds": [
      "Hernia, anterior diaphragmatic"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01098",
    "question": "What is associated with Splenic cyst?",
    "seeds": [
      "Splenic cyst"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01099",
    "question": "What phenotype is associated with AL amyloidosis?",
    "seeds": [
      "AL amyloidosis"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01100",
    "question": "What is associated with Reduced erythrocyte porphobilinogen deaminase activity?",
    "seeds": [
      "Reduced erythrocyte porphobilinogen deaminase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01101",
    "question": "What is associated with Arcuate vein lumen organized thrombi?",
    "seeds": [
      "Arcuate vein lumen organized thrombi"
    ],
    "gold_answer": "Abnormal arcuate vein lumen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01102",
    "question": "What is associated with Localized to upper eyelid?",
    "seeds": [
      "Localized to upper eyelid"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01103",
    "question": "What is associated with Elevated CSF dihydrouracil concentration?",
    "seeds": [
      "Elevated CSF dihydrouracil concentration"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01104",
    "question": "What is associated with Macular dystrophy, X-linked?",
    "seeds": [
      "Macular dystrophy, X-linked"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01105",
    "question": "What is associated with Spina bifida occulta at L5?",
    "seeds": [
      "Spina bifida occulta at L5"
    ],
    "gold_answer": "Spinal dysraphism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01106",
    "question": "What phenotype is associated with Septopreoptic holoprosencephaly?",
    "seeds": [
      "Septopreoptic holoprosencephaly"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01107",
    "question": "What is associated with Agenesis of primary maxillary lateral incisor?",
    "seeds": [
      "Agenesis of primary maxillary lateral incisor"
    ],
    "gold_answer": "Agenesis of incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01108",
    "question": "What is associated with Bursitis?",
    "seeds": [
      "Bursitis"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01109",
    "question": "What is associated with Plantar edema?",
    "seeds": [
      "Plantar edema"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01110",
    "question": "What phenotype is associated with Developmental delay, dysmorphic facies, and brain anomalies?",
    "seeds": [
      "Developmental delay, dysmorphic facies, and brain anomalies"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01111",
    "question": "What is associated with Malignant hyperthermia, susceptibility to, 3?",
    "seeds": [
      "Malignant hyperthermia, susceptibility to, 3"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01112",
    "question": "What phenotype is associated with Urticaria, aquagenic?",
    "seeds": [
      "Urticaria, aquagenic"
    ],
    "gold_answer": "Urticaria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01113",
    "question": "What is associated with Reduced muscle aconitase activity?",
    "seeds": [
      "Reduced muscle aconitase activity"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01114",
    "question": "What phenotype is associated with Perrault syndrome?",
    "seeds": [
      "Perrault syndrome"
    ],
    "gold_answer": "Cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01115",
    "question": "What is associated with Brain fog?",
    "seeds": [
      "Brain fog"
    ],
    "gold_answer": "Cognitive impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01116",
    "question": "What is associated with Persistent falcine venous sinus?",
    "seeds": [
      "Persistent falcine venous sinus"
    ],
    "gold_answer": "Abnormal cerebral venous sinus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01117",
    "question": "What phenotype is associated with Hepatic venoocclusive disease with immunodeficiency?",
    "seeds": [
      "Hepatic venoocclusive disease with immunodeficiency"
    ],
    "gold_answer": "Endocardial fibrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01118",
    "question": "What is associated with 3-methylglutaconic aciduria type 3?",
    "seeds": [
      "3-methylglutaconic aciduria type 3"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01119",
    "question": "What is associated with Epileptic aura?",
    "seeds": [
      "Epileptic aura"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01120",
    "question": "What is associated with Urethrocele?",
    "seeds": [
      "Urethrocele"
    ],
    "gold_answer": "Abnormality of the lower urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01121",
    "question": "What phenotype is associated with Congenitally corrected transposition of the great arteries?",
    "seeds": [
      "Congenitally corrected transposition of the great arteries"
    ],
    "gold_answer": "Mesocardia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01122",
    "question": "What is associated with Elevated circulating C12 acylcarnitine concentration?",
    "seeds": [
      "Elevated circulating C12 acylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01123",
    "question": "What is associated with Periventricular nodular heterotopia?",
    "seeds": [
      "Periventricular nodular heterotopia"
    ],
    "gold_answer": "Abnormality of the pylorus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01124",
    "question": "What phenotype is associated with Encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities?",
    "seeds": [
      "Encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities"
    ],
    "gold_answer": "Absent posterior alpha rhythm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01125",
    "question": "What is associated with Abnormality of the endocrine system?",
    "seeds": [
      "Abnormality of the endocrine system"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01126",
    "question": "What is associated with Fundus hyperpigmentation?",
    "seeds": [
      "Fundus hyperpigmentation"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01127",
    "question": "What is associated with Thoracoabdominal eventration?",
    "seeds": [
      "Thoracoabdominal eventration"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01128",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 25?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 25"
    ],
    "gold_answer": "Herniation of intervertebral nuclei",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01129",
    "question": "What is associated with Osteogenesis imperfecta, type IX?",
    "seeds": [
      "Osteogenesis imperfecta, type IX"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01130",
    "question": "What is associated with Methemoglobinemia, Alpha type?",
    "seeds": [
      "Methemoglobinemia, Alpha type"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01131",
    "question": "What is associated with Primary triglyceride deposit cardiomyovasculopathy?",
    "seeds": [
      "Primary triglyceride deposit cardiomyovasculopathy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01132",
    "question": "What is associated with Reduced tissue arginine:glycine amidinotransferase activity?",
    "seeds": [
      "Reduced tissue arginine:glycine amidinotransferase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01133",
    "question": "What is associated with Small intestinal polyp?",
    "seeds": [
      "Small intestinal polyp"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01134",
    "question": "What is associated with Inability to puff cheeks?",
    "seeds": [
      "Inability to puff cheeks"
    ],
    "gold_answer": "Abnormality of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01135",
    "question": "What is associated with Parkinson disease 23, autosomal recessive early-onset?",
    "seeds": [
      "Parkinson disease 23, autosomal recessive early-onset"
    ],
    "gold_answer": "Abnormal cerebral cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01136",
    "question": "What is associated with Premature ovarian failure 7?",
    "seeds": [
      "Premature ovarian failure 7"
    ],
    "gold_answer": "Aplasia/hypoplasia of the uterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01137",
    "question": "What is associated with Severe infection?",
    "seeds": [
      "Severe infection"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01138",
    "question": "What phenotype is associated with Silver-Russell syndrome?",
    "seeds": [
      "Silver-Russell syndrome"
    ],
    "gold_answer": "Cafe-au-lait spot",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01139",
    "question": "What is associated with Septate gallbladder?",
    "seeds": [
      "Septate gallbladder"
    ],
    "gold_answer": "Abnormality of the gallbladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01140",
    "question": "What is associated with Exstrophy?",
    "seeds": [
      "Exstrophy"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01141",
    "question": "What is associated with Abnormal enzyme activity in cultured fibroblasts?",
    "seeds": [
      "Abnormal enzyme activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01142",
    "question": "What is associated with Hematological neoplasm?",
    "seeds": [
      "Hematological neoplasm"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01143",
    "question": "What is associated with Occipital cortical atrophy?",
    "seeds": [
      "Occipital cortical atrophy"
    ],
    "gold_answer": "Cerebral atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01144",
    "question": "What is associated with Abnormality of toe proximal phalanx?",
    "seeds": [
      "Abnormality of toe proximal phalanx"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01145",
    "question": "What is associated with Round face?",
    "seeds": [
      "Round face"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01146",
    "question": "What is associated with Epiphyseal stippling of the metacarpals?",
    "seeds": [
      "Epiphyseal stippling of the metacarpals"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01147",
    "question": "What phenotype is associated with Epilepsy, idiopathic generalized, susceptibility to, 3?",
    "seeds": [
      "Epilepsy, idiopathic generalized, susceptibility to, 3"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01148",
    "question": "What is associated with Urinary hesitancy?",
    "seeds": [
      "Urinary hesitancy"
    ],
    "gold_answer": "Abnormality of the lower urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01149",
    "question": "What is associated with Acrodysostosis?",
    "seeds": [
      "Acrodysostosis"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01150",
    "question": "What is associated with Fetal iodine deficiency disorder?",
    "seeds": [
      "Fetal iodine deficiency disorder"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01151",
    "question": "What is associated with Muscular subvalvular aortic stenosis?",
    "seeds": [
      "Muscular subvalvular aortic stenosis"
    ],
    "gold_answer": "Abnormal left ventricular outflow tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01152",
    "question": "What is associated with Laterally deficient tibial plateaux?",
    "seeds": [
      "Laterally deficient tibial plateaux"
    ],
    "gold_answer": "Abnormality of the calf",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01153",
    "question": "What phenotype is associated with Hypertriglyceridemia, familial?",
    "seeds": [
      "Hypertriglyceridemia, familial"
    ],
    "gold_answer": "Increased VLDL cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01154",
    "question": "What is associated with Intellectual developmental disorder and microcephaly with pontine and cerebellar hypoplasia?",
    "seeds": [
      "Intellectual developmental disorder and microcephaly with pontine and cerebellar hypoplasia"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01155",
    "question": "What is associated with Florid cemento-osseous dysplasia?",
    "seeds": [
      "Florid cemento-osseous dysplasia"
    ],
    "gold_answer": "Abnormality of the voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01156",
    "question": "What is associated with Alpha-aminobutyric aciduria?",
    "seeds": [
      "Alpha-aminobutyric aciduria"
    ],
    "gold_answer": "Aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01157",
    "question": "What is associated with Pituitary spindle cell oncocytoma?",
    "seeds": [
      "Pituitary spindle cell oncocytoma"
    ],
    "gold_answer": "Abnormal pituitary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01158",
    "question": "What phenotype is associated with Angelman syndrome due to imprinting defect in 15q11-q13?",
    "seeds": [
      "Angelman syndrome due to imprinting defect in 15q11-q13"
    ],
    "gold_answer": "Iris hypopigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01159",
    "question": "What is associated with ALG8-CDG?",
    "seeds": [
      "ALG8-CDG"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01160",
    "question": "What is associated with Blocked Eustachian tube?",
    "seeds": [
      "Blocked Eustachian tube"
    ],
    "gold_answer": "Abnormal Eustachian tube morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01161",
    "question": "What is associated with Progressive neurologic deterioration?",
    "seeds": [
      "Progressive neurologic deterioration"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01162",
    "question": "What is associated with Triangular shaped phalanges of the 2nd toe?",
    "seeds": [
      "Triangular shaped phalanges of the 2nd toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01163",
    "question": "What is associated with Hepatic bridging fibrosis?",
    "seeds": [
      "Hepatic bridging fibrosis"
    ],
    "gold_answer": "Hepatic fibrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01164",
    "question": "What phenotype is associated with Carnitine palmitoyl transferase II deficiency, neonatal form?",
    "seeds": [
      "Carnitine palmitoyl transferase II deficiency, neonatal form"
    ],
    "gold_answer": "Agenesis of corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01165",
    "question": "What is associated with Anosmia, congenital?",
    "seeds": [
      "Anosmia, congenital"
    ],
    "gold_answer": "Abnormality of the sense of smell",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01166",
    "question": "What is associated with Abnormal intestine morphology?",
    "seeds": [
      "Abnormal intestine morphology"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01167",
    "question": "What is associated with Parastremmatic dwarfism?",
    "seeds": [
      "Parastremmatic dwarfism"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01168",
    "question": "What is associated with Elevated circulating 3-hydroxyhexadecanoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating 3-hydroxyhexadecanoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01169",
    "question": "What is associated with Dysregulated negative emotional state?",
    "seeds": [
      "Dysregulated negative emotional state"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01170",
    "question": "What is associated with Proteasome-associated autoinflammatory syndrome 4?",
    "seeds": [
      "Proteasome-associated autoinflammatory syndrome 4"
    ],
    "gold_answer": "Joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01171",
    "question": "What is associated with Dysharmonic delayed bone age?",
    "seeds": [
      "Dysharmonic delayed bone age"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01172",
    "question": "What is associated with Symphalangism, distal, with microdontia, dental pulp stones, and narrowedzygomatic arch?",
    "seeds": [
      "Symphalangism, distal, with microdontia, dental pulp stones, and narrowedzygomatic arch"
    ],
    "gold_answer": "Phalangeal cone-shaped epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01173",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 45?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 45"
    ],
    "gold_answer": "Abnormal cerebral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01174",
    "question": "What is associated with Arterial stenosis?",
    "seeds": [
      "Arterial stenosis"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01175",
    "question": "What is associated with Decreased CD4+ effector memory T cell proportion?",
    "seeds": [
      "Decreased CD4+ effector memory T cell proportion"
    ],
    "gold_answer": "Increased CD4+ memory T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01176",
    "question": "What is associated with Abnormal circulating chemokine concentration?",
    "seeds": [
      "Abnormal circulating chemokine concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01177",
    "question": "What is associated with Delayed ability to roll over?",
    "seeds": [
      "Delayed ability to roll over"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01178",
    "question": "What is associated with Subchorionic thrombohematoma?",
    "seeds": [
      "Subchorionic thrombohematoma"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01179",
    "question": "What phenotype is associated with von Hippel-Lindau syndrome?",
    "seeds": [
      "von Hippel-Lindau syndrome"
    ],
    "gold_answer": "Pulmonary infiltrates",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01180",
    "question": "What is associated with Abnormal total natural killer cell count?",
    "seeds": [
      "Abnormal total natural killer cell count"
    ],
    "gold_answer": "Abnormal natural killer cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01181",
    "question": "What is associated with Deafness, autosomal recessive 36, with or without vestibular involvement?",
    "seeds": [
      "Deafness, autosomal recessive 36, with or without vestibular involvement"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01182",
    "question": "What is associated with Spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome?",
    "seeds": [
      "Spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome"
    ],
    "gold_answer": "Impaired continence",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01183",
    "question": "What is associated with Nystagmus 4, congenital, autosomal dominant?",
    "seeds": [
      "Nystagmus 4, congenital, autosomal dominant"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01184",
    "question": "What is associated with Split-Hand/foot malformation 2?",
    "seeds": [
      "Split-Hand/foot malformation 2"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the metacarpal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01185",
    "question": "What is associated with Capillary leak?",
    "seeds": [
      "Capillary leak"
    ],
    "gold_answer": "Abnormal capillary physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01186",
    "question": "What is associated with Elevated circulating tenascin-C concentration?",
    "seeds": [
      "Elevated circulating tenascin-C concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01187",
    "question": "What is associated with Hypoisoleucinemia?",
    "seeds": [
      "Hypoisoleucinemia"
    ],
    "gold_answer": "Abnormal circulating isoleucine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01188",
    "question": "What is associated with Deafness, autosomal recessive 115?",
    "seeds": [
      "Deafness, autosomal recessive 115"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01189",
    "question": "What is associated with Subepidermal blistering?",
    "seeds": [
      "Subepidermal blistering"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01190",
    "question": "What phenotype is associated with Fibular aplasia-complex brachydactyly syndrome?",
    "seeds": [
      "Fibular aplasia-complex brachydactyly syndrome"
    ],
    "gold_answer": "Micromelia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01191",
    "question": "What is associated with Abnormal erythrocyte enzyme concentration or activity?",
    "seeds": [
      "Abnormal erythrocyte enzyme concentration or activity"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01192",
    "question": "What is associated with Curved phalanges of the 5th finger?",
    "seeds": [
      "Curved phalanges of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01193",
    "question": "What is associated with Decreased HDL3a concentration?",
    "seeds": [
      "Decreased HDL3a concentration"
    ],
    "gold_answer": "Abnormal HDL subfraction concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01194",
    "question": "What is associated with Myotonic dystrophy 1?",
    "seeds": [
      "Myotonic dystrophy 1"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01195",
    "question": "What is associated with Torus palatinus?",
    "seeds": [
      "Torus palatinus"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01196",
    "question": "What is associated with Elevated urinary histamine level?",
    "seeds": [
      "Elevated urinary histamine level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01197",
    "question": "What is associated with Peripheral visual field loss?",
    "seeds": [
      "Peripheral visual field loss"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01198",
    "question": "What is associated with Pontocerebellar hypoplasia type 10?",
    "seeds": [
      "Pontocerebellar hypoplasia type 10"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01199",
    "question": "What is associated with Abnormal transition from wakefulness to sleep?",
    "seeds": [
      "Abnormal transition from wakefulness to sleep"
    ],
    "gold_answer": "Parasomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01200",
    "question": "What is associated with Renal tubular acidosis?",
    "seeds": [
      "Renal tubular acidosis"
    ],
    "gold_answer": "Renal tubular dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01201",
    "question": "What is associated with Intercrural pterygium?",
    "seeds": [
      "Intercrural pterygium"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01202",
    "question": "What is associated with Elevated urinary catecholamine level?",
    "seeds": [
      "Elevated urinary catecholamine level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01203",
    "question": "What is associated with Chordoma?",
    "seeds": [
      "Chordoma"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01204",
    "question": "What is associated with Hemangioma?",
    "seeds": [
      "Hemangioma"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01205",
    "question": "What is associated with Sensorineural hearing loss-early graying-essential tremor syndrome?",
    "seeds": [
      "Sensorineural hearing loss-early graying-essential tremor syndrome"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01206",
    "question": "What is associated with Epiphyseal stippling?",
    "seeds": [
      "Epiphyseal stippling"
    ],
    "gold_answer": "Abnormal epiphyseal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01207",
    "question": "What phenotype is associated with Growth delay due to insulin-like growth factor type 1 deficiency?",
    "seeds": [
      "Growth delay due to insulin-like growth factor type 1 deficiency"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01208",
    "question": "What is associated with Septooptic dysplasia?",
    "seeds": [
      "Septooptic dysplasia"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01209",
    "question": "What is associated with Leukocyte inclusion bodies?",
    "seeds": [
      "Leukocyte inclusion bodies"
    ],
    "gold_answer": "Abnormal neutrophil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01210",
    "question": "What is associated with Toe dactylitis?",
    "seeds": [
      "Toe dactylitis"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01211",
    "question": "What is associated with Mosaic attenuation pattern in lung?",
    "seeds": [
      "Mosaic attenuation pattern in lung"
    ],
    "gold_answer": "Abnormal pulmonary thoracic imaging finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01212",
    "question": "What is associated with Extremities cold to touch?",
    "seeds": [
      "Extremities cold to touch"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01213",
    "question": "What is associated with Erythroid hypoplasia?",
    "seeds": [
      "Erythroid hypoplasia"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01214",
    "question": "What is associated with Decreased circulating parathyroid hormone level?",
    "seeds": [
      "Decreased circulating parathyroid hormone level"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01215",
    "question": "What is associated with Prolonged G2 phase of cell cycle?",
    "seeds": [
      "Prolonged G2 phase of cell cycle"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01216",
    "question": "What is associated with Neutrophilia, hereditary?",
    "seeds": [
      "Neutrophilia, hereditary"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01217",
    "question": "What phenotype is associated with Warburg micro syndrome 4?",
    "seeds": [
      "Warburg micro syndrome 4"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01218",
    "question": "What is associated with Focal emotional seizure with anger?",
    "seeds": [
      "Focal emotional seizure with anger"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01219",
    "question": "What is associated with Femoral osteopoikilosis?",
    "seeds": [
      "Femoral osteopoikilosis"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01220",
    "question": "What is associated with Short middle phalanx of the 5th finger?",
    "seeds": [
      "Short middle phalanx of the 5th finger"
    ],
    "gold_answer": "Short finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01221",
    "question": "What phenotype is associated with Epiphyseal dysplasia, multiple, 1?",
    "seeds": [
      "Epiphyseal dysplasia, multiple, 1"
    ],
    "gold_answer": "Generalized joint hypermobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01222",
    "question": "What is associated with Broad distal phalanx of the 5th toe?",
    "seeds": [
      "Broad distal phalanx of the 5th toe"
    ],
    "gold_answer": "Broad phalanges of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01223",
    "question": "What phenotype is associated with Pulmonary hypertension, primary, 6?",
    "seeds": [
      "Pulmonary hypertension, primary, 6"
    ],
    "gold_answer": "Failure to thrive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01224",
    "question": "What phenotype is associated with Leukodystrophy, progressive, early childhood-onset?",
    "seeds": [
      "Leukodystrophy, progressive, early childhood-onset"
    ],
    "gold_answer": "Peripheral neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01225",
    "question": "What is associated with Night blindness, congenital stationary, autosomal dominant 1?",
    "seeds": [
      "Night blindness, congenital stationary, autosomal dominant 1"
    ],
    "gold_answer": "Abnormal light- and dark-adapted electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01226",
    "question": "What is associated with Infant botulism?",
    "seeds": [
      "Infant botulism"
    ],
    "gold_answer": "Abnormal esophagus physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01227",
    "question": "What is associated with Flexner-Wintersteiner rosette?",
    "seeds": [
      "Flexner-Wintersteiner rosette"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01228",
    "question": "What is associated with Abnormal static perimetry test?",
    "seeds": [
      "Abnormal static perimetry test"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01229",
    "question": "What is associated with Patchy sclerosis of finger phalanx?",
    "seeds": [
      "Patchy sclerosis of finger phalanx"
    ],
    "gold_answer": "Patchy sclerosis of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01230",
    "question": "What phenotype is associated with Proximal toe symphalangism?",
    "seeds": [
      "Proximal toe symphalangism"
    ],
    "gold_answer": "Finger clinodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01231",
    "question": "What is associated with Leukemia, acute lymphocytic, susceptibility to, 1?",
    "seeds": [
      "Leukemia, acute lymphocytic, susceptibility to, 1"
    ],
    "gold_answer": "Acute leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01232",
    "question": "What is associated with Finger flexor weakness?",
    "seeds": [
      "Finger flexor weakness"
    ],
    "gold_answer": "Hand muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01233",
    "question": "What is associated with Intestinal fistula?",
    "seeds": [
      "Intestinal fistula"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01234",
    "question": "What is associated with Urethral atresia, female?",
    "seeds": [
      "Urethral atresia, female"
    ],
    "gold_answer": "Urethral atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01235",
    "question": "What is associated with Aplasia of the 5th metacarpal?",
    "seeds": [
      "Aplasia of the 5th metacarpal"
    ],
    "gold_answer": "Aplasia of metacarpal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01236",
    "question": "What is associated with Prostate mass?",
    "seeds": [
      "Prostate mass"
    ],
    "gold_answer": "Abnormal prostate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01237",
    "question": "What is associated with Hypoplastic carotid canal?",
    "seeds": [
      "Hypoplastic carotid canal"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01238",
    "question": "What is associated with Incomplete partition of the cochlea type II?",
    "seeds": [
      "Incomplete partition of the cochlea type II"
    ],
    "gold_answer": "Cochlear malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01239",
    "question": "What is associated with Epilepsy, idiopathic generalized, susceptibility to, 9?",
    "seeds": [
      "Epilepsy, idiopathic generalized, susceptibility to, 9"
    ],
    "gold_answer": "Vertigo",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01240",
    "question": "What is associated with Hypoplasia of the ulna?",
    "seeds": [
      "Hypoplasia of the ulna"
    ],
    "gold_answer": "Forearm undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01241",
    "question": "What is associated with Alpha-Fetoprotein deficiency?",
    "seeds": [
      "Alpha-Fetoprotein deficiency"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01242",
    "question": "What is associated with Neuronopathy, distal hereditary motor, type IIB?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, type IIB"
    ],
    "gold_answer": "Abnormality of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01243",
    "question": "What is associated with Abnormal respiratory system physiology?",
    "seeds": [
      "Abnormal respiratory system physiology"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01244",
    "question": "What is associated with Abnormal circulating fibroblast growth factor 23 concentration?",
    "seeds": [
      "Abnormal circulating fibroblast growth factor 23 concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01245",
    "question": "What is associated with Neutral hyperaminoaciduria?",
    "seeds": [
      "Neutral hyperaminoaciduria"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01246",
    "question": "What phenotype is associated with Unilateral renal hypoplasia?",
    "seeds": [
      "Unilateral renal hypoplasia"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01247",
    "question": "What is associated with Narcolepsy type 1?",
    "seeds": [
      "Narcolepsy type 1"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01248",
    "question": "What is associated with Ophthalmoplegia totalis with ptosis and miosis?",
    "seeds": [
      "Ophthalmoplegia totalis with ptosis and miosis"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01249",
    "question": "What is associated with Myoclonic seizure?",
    "seeds": [
      "Myoclonic seizure"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01250",
    "question": "What is associated with Abnormal speech pattern?",
    "seeds": [
      "Abnormal speech pattern"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01251",
    "question": "What is associated with Hypoplastic radial head?",
    "seeds": [
      "Hypoplastic radial head"
    ],
    "gold_answer": "Abnormality of the radial head",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01252",
    "question": "What is associated with True distance exotropia?",
    "seeds": [
      "True distance exotropia"
    ],
    "gold_answer": "Distance exotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01253",
    "question": "What is associated with X-linked Charcot-Marie-Tooth disease type 1?",
    "seeds": [
      "X-linked Charcot-Marie-Tooth disease type 1"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01254",
    "question": "What is associated with Increased vertical cup-to-disc ratio?",
    "seeds": [
      "Increased vertical cup-to-disc ratio"
    ],
    "gold_answer": "Increased cup-to-disc ratio",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01255",
    "question": "What is associated with Pulmonary mycetoma?",
    "seeds": [
      "Pulmonary mycetoma"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01256",
    "question": "What is associated with CLOVES syndrome?",
    "seeds": [
      "CLOVES syndrome"
    ],
    "gold_answer": "Hematuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01257",
    "question": "What phenotype is associated with Livedoid vasculopathy?",
    "seeds": [
      "Livedoid vasculopathy"
    ],
    "gold_answer": "Anti-Ro52/TRIM21 antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01258",
    "question": "What is associated with Glycogen storage disease due to glucose-6-phosphatase deficiency type Ia?",
    "seeds": [
      "Glycogen storage disease due to glucose-6-phosphatase deficiency type Ia"
    ],
    "gold_answer": "G6PC1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01259",
    "question": "What is associated with Hepatic amyloidosis?",
    "seeds": [
      "Hepatic amyloidosis"
    ],
    "gold_answer": "Amyloid deposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01260",
    "question": "What phenotype is associated with Obesity and hypopigmentation?",
    "seeds": [
      "Obesity and hypopigmentation"
    ],
    "gold_answer": "Hepatic steatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01261",
    "question": "What is associated with Requires heterozygosity?",
    "seeds": [
      "Requires heterozygosity"
    ],
    "gold_answer": "Inheritance qualifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01262",
    "question": "What is associated with Urethral stricture?",
    "seeds": [
      "Urethral stricture"
    ],
    "gold_answer": "Abnormality of the urethra",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01263",
    "question": "What is associated with Acrokeratosis?",
    "seeds": [
      "Acrokeratosis"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01264",
    "question": "What is associated with Scapuloperoneal myopathy?",
    "seeds": [
      "Scapuloperoneal myopathy"
    ],
    "gold_answer": "Amyotrophy involving the shoulder musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01265",
    "question": "What is associated with Charcot-Marie-Tooth disease, demyelinating, type 4F?",
    "seeds": [
      "Charcot-Marie-Tooth disease, demyelinating, type 4F"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01266",
    "question": "What is associated with Colonic fibrinopurulent exudate?",
    "seeds": [
      "Colonic fibrinopurulent exudate"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01267",
    "question": "What is associated with Aplasia/Hypoplasia involving the sinuses?",
    "seeds": [
      "Aplasia/Hypoplasia involving the sinuses"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01268",
    "question": "What is associated with Positive CSF VDRL test?",
    "seeds": [
      "Positive CSF VDRL test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01269",
    "question": "What is associated with Hypoalbuminemia?",
    "seeds": [
      "Hypoalbuminemia"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01270",
    "question": "What is associated with Dermatitis herpetiformis, familial?",
    "seeds": [
      "Dermatitis herpetiformis, familial"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01271",
    "question": "What is associated with Preterm premature rupture of the membranes?",
    "seeds": [
      "Preterm premature rupture of the membranes"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01272",
    "question": "What phenotype is associated with Heme oxygenase-1 deficiency?",
    "seeds": [
      "Heme oxygenase-1 deficiency"
    ],
    "gold_answer": "Cervical lymphadenopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01273",
    "question": "What is associated with Enlarged lacrimal glands?",
    "seeds": [
      "Enlarged lacrimal glands"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01274",
    "question": "What phenotype is associated with Neuronopathy, distal hereditary motor, type VIIA?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, type VIIA"
    ],
    "gold_answer": "Vocal cord paresis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01275",
    "question": "What phenotype is associated with X-linked acrogigantism?",
    "seeds": [
      "X-linked acrogigantism"
    ],
    "gold_answer": "Abdominal distention",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01276",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 20?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 20"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01277",
    "question": "What is associated with Mesangial matrix expansion?",
    "seeds": [
      "Mesangial matrix expansion"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01278",
    "question": "What is associated with Haim-Munk syndrome?",
    "seeds": [
      "Haim-Munk syndrome"
    ],
    "gold_answer": "Abnormal skin morphology of the palm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01279",
    "question": "What is associated with Autosomal recessive ataxia due to ubiquinone deficiency?",
    "seeds": [
      "Autosomal recessive ataxia due to ubiquinone deficiency"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01280",
    "question": "What phenotype is associated with Familial infantile bilateral striatal necrosis?",
    "seeds": [
      "Familial infantile bilateral striatal necrosis"
    ],
    "gold_answer": "Esophageal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01281",
    "question": "What is associated with Primary hyperparathyroidism?",
    "seeds": [
      "Primary hyperparathyroidism"
    ],
    "gold_answer": "Abnormality of the parathyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01282",
    "question": "What is associated with Abnormal spermatogenesis?",
    "seeds": [
      "Abnormal spermatogenesis"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01283",
    "question": "What phenotype is associated with Linear IgA dermatosis?",
    "seeds": [
      "Linear IgA dermatosis"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01284",
    "question": "What is associated with Immunodeficiency due to purine nucleoside phosphorylase deficiency?",
    "seeds": [
      "Immunodeficiency due to purine nucleoside phosphorylase deficiency"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01285",
    "question": "What is associated with Anosmia?",
    "seeds": [
      "Anosmia"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01286",
    "question": "What phenotype is associated with Argininosuccinic aciduria?",
    "seeds": [
      "Argininosuccinic aciduria"
    ],
    "gold_answer": "Attention deficit hyperactivity disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01287",
    "question": "What phenotype is associated with Advanced sleep phase syndrome, familial, 1?",
    "seeds": [
      "Advanced sleep phase syndrome, familial, 1"
    ],
    "gold_answer": "Depression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01288",
    "question": "What phenotype is associated with Yuan-Harel-Lupski syndrome?",
    "seeds": [
      "Yuan-Harel-Lupski syndrome"
    ],
    "gold_answer": "Bicuspid aortic valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01289",
    "question": "What is associated with History of mastectomy?",
    "seeds": [
      "History of mastectomy"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01290",
    "question": "What is associated with Hypoplastic ischiopubic ramus?",
    "seeds": [
      "Hypoplastic ischiopubic ramus"
    ],
    "gold_answer": "Hypoplastic pubic bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01291",
    "question": "What is associated with Familial congenital mirror movements?",
    "seeds": [
      "Familial congenital mirror movements"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01292",
    "question": "What phenotype is associated with Galloway-Mowat syndrome 5?",
    "seeds": [
      "Galloway-Mowat syndrome 5"
    ],
    "gold_answer": "Periventricular leukomalacia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01293",
    "question": "What is associated with Reduced platelet dense granules?",
    "seeds": [
      "Reduced platelet dense granules"
    ],
    "gold_answer": "Abnormal dense granules",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01294",
    "question": "What is associated with Intellectual disability-alacrima-achalasia syndrome?",
    "seeds": [
      "Intellectual disability-alacrima-achalasia syndrome"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01295",
    "question": "What is associated with Reduced bone mineral density?",
    "seeds": [
      "Reduced bone mineral density"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01296",
    "question": "What is associated with 1-minute APGAR score of 3?",
    "seeds": [
      "1-minute APGAR score of 3"
    ],
    "gold_answer": "Low APGAR score",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01297",
    "question": "What is associated with Coffin-Siris syndrome 4?",
    "seeds": [
      "Coffin-Siris syndrome 4"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01298",
    "question": "What is associated with Pancreas divisum?",
    "seeds": [
      "Pancreas divisum"
    ],
    "gold_answer": "Abnormal pancreas morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01299",
    "question": "What is associated with Elongated mitochondria?",
    "seeds": [
      "Elongated mitochondria"
    ],
    "gold_answer": "Abnormal mitochondrial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01300",
    "question": "What is associated with Herpetiform corneal ulceration?",
    "seeds": [
      "Herpetiform corneal ulceration"
    ],
    "gold_answer": "Corneal ulceration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01301",
    "question": "What is associated with Abnormal CSF neopterin concentration?",
    "seeds": [
      "Abnormal CSF neopterin concentration"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01302",
    "question": "What phenotype is associated with Luscan-Lumish syndrome?",
    "seeds": [
      "Luscan-Lumish syndrome"
    ],
    "gold_answer": "High anterior hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01303",
    "question": "What is associated with Intellectual developmental disorder with dysmorphic facies, speech delay, and T-cell abnormalities?",
    "seeds": [
      "Intellectual developmental disorder with dysmorphic facies, speech delay, and T-cell abnormalities"
    ],
    "gold_answer": "Abnormality of dental eruption",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01304",
    "question": "What phenotype is associated with Primary hyperoxaluria type 1?",
    "seeds": [
      "Primary hyperoxaluria type 1"
    ],
    "gold_answer": "Calcinosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01305",
    "question": "What is associated with Charcot-Marie-Tooth disease type 2B2?",
    "seeds": [
      "Charcot-Marie-Tooth disease type 2B2"
    ],
    "gold_answer": "PNKP",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01306",
    "question": "What is associated with Anorgasmia?",
    "seeds": [
      "Anorgasmia"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01307",
    "question": "What is associated with Familial porphyria cutanea tarda?",
    "seeds": [
      "Familial porphyria cutanea tarda"
    ],
    "gold_answer": "HFE",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "modifying_germline_mutation_in"
    }
  },
  {
    "query_id": "orph_train_01308",
    "question": "What is associated with Bradylalia?",
    "seeds": [
      "Bradylalia"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01309",
    "question": "What is associated with Non-restorative sleep?",
    "seeds": [
      "Non-restorative sleep"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01310",
    "question": "What is associated with Focal head nodding automatism seizure?",
    "seeds": [
      "Focal head nodding automatism seizure"
    ],
    "gold_answer": "Focal motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01311",
    "question": "What is associated with Corneal endothelial dystrophy and perceptive deafness?",
    "seeds": [
      "Corneal endothelial dystrophy and perceptive deafness"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01312",
    "question": "What is associated with Reduced antigen-specific T cell proliferation?",
    "seeds": [
      "Reduced antigen-specific T cell proliferation"
    ],
    "gold_answer": "Impaired antigen-specific response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01313",
    "question": "What is associated with Decreased circulating epinephrine concentration?",
    "seeds": [
      "Decreased circulating epinephrine concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01314",
    "question": "What is associated with Camptodactyly 1?",
    "seeds": [
      "Camptodactyly 1"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01315",
    "question": "What is associated with Cockayne syndrome, type B?",
    "seeds": [
      "Cockayne syndrome, type B"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01316",
    "question": "What is associated with Schöpf-Schulz-Passarge syndrome?",
    "seeds": [
      "Schöpf-Schulz-Passarge syndrome"
    ],
    "gold_answer": "Palmar hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01317",
    "question": "What is associated with Pulmonary tuberculosis?",
    "seeds": [
      "Pulmonary tuberculosis"
    ],
    "gold_answer": "Opportunistic infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01318",
    "question": "What is associated with Reduced tissue fructose-1,6-bisphosphatase activity?",
    "seeds": [
      "Reduced tissue fructose-1,6-bisphosphatase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01319",
    "question": "What is associated with Excessively quiet speech?",
    "seeds": [
      "Excessively quiet speech"
    ],
    "gold_answer": "Abnormal speech volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01320",
    "question": "What is associated with Small thumb epiphysis?",
    "seeds": [
      "Small thumb epiphysis"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01321",
    "question": "What is associated with Congenital malformation of the left heart?",
    "seeds": [
      "Congenital malformation of the left heart"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01322",
    "question": "What is associated with Facial nerve compression?",
    "seeds": [
      "Facial nerve compression"
    ],
    "gold_answer": "Abnormal cranial nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01323",
    "question": "What is associated with Fusiform aortic arch aneurysm?",
    "seeds": [
      "Fusiform aortic arch aneurysm"
    ],
    "gold_answer": "Thoracic aortic aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01324",
    "question": "What is associated with Eiken syndrome?",
    "seeds": [
      "Eiken syndrome"
    ],
    "gold_answer": "Abnormality of primary teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01325",
    "question": "What is associated with Abnormal coronary artery morphology?",
    "seeds": [
      "Abnormal coronary artery morphology"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01326",
    "question": "What is associated with Peg-shaped maxillary lateral incisors?",
    "seeds": [
      "Peg-shaped maxillary lateral incisors"
    ],
    "gold_answer": "Abnormal dental morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01327",
    "question": "What is associated with Moderate hypermetropia?",
    "seeds": [
      "Moderate hypermetropia"
    ],
    "gold_answer": "Abnormality of refraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01328",
    "question": "What is associated with Sleep disturbance?",
    "seeds": [
      "Sleep disturbance"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01329",
    "question": "What is associated with Ileoileal intussusception?",
    "seeds": [
      "Ileoileal intussusception"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01330",
    "question": "What is associated with Proximal spinal muscular atrophy type 1?",
    "seeds": [
      "Proximal spinal muscular atrophy type 1"
    ],
    "gold_answer": "SMN1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01331",
    "question": "What is associated with Abnormal circulating gonadotropin concentration?",
    "seeds": [
      "Abnormal circulating gonadotropin concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01332",
    "question": "What is associated with Mitochondrial complex II deficiency, nuclear type 2?",
    "seeds": [
      "Mitochondrial complex II deficiency, nuclear type 2"
    ],
    "gold_answer": "Abnormal brain N-acetyl aspartate level by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01333",
    "question": "What phenotype is associated with Aprosencephaly and cerebellar dysgenesis?",
    "seeds": [
      "Aprosencephaly and cerebellar dysgenesis"
    ],
    "gold_answer": "Aprosencephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01334",
    "question": "What is associated with Ultra-low vision?",
    "seeds": [
      "Ultra-low vision"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01335",
    "question": "What is associated with Acromesomelic dysplasia, Maroteaux type?",
    "seeds": [
      "Acromesomelic dysplasia, Maroteaux type"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01336",
    "question": "What is associated with Abnormal HDL2b concentration?",
    "seeds": [
      "Abnormal HDL2b concentration"
    ],
    "gold_answer": "Abnormal HDL cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01337",
    "question": "What is associated with Hypoplasia of latissimus dorsi muscle?",
    "seeds": [
      "Hypoplasia of latissimus dorsi muscle"
    ],
    "gold_answer": "Abnormality of the musculature of the thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01338",
    "question": "What is associated with Abnormal neoplastic cell morphology?",
    "seeds": [
      "Abnormal neoplastic cell morphology"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01339",
    "question": "What is associated with Elevated circulating N-carbamyl-beta-aminoisobutyric acid concentration?",
    "seeds": [
      "Elevated circulating N-carbamyl-beta-aminoisobutyric acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01340",
    "question": "What is associated with Progressive cervical vertebral spine fusion?",
    "seeds": [
      "Progressive cervical vertebral spine fusion"
    ],
    "gold_answer": "Vertebral fusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01341",
    "question": "What phenotype is associated with Exostoses, multiple, type II?",
    "seeds": [
      "Exostoses, multiple, type II"
    ],
    "gold_answer": "Madelung-like forearm deformities",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01342",
    "question": "What is associated with Hepatic calcification?",
    "seeds": [
      "Hepatic calcification"
    ],
    "gold_answer": "Ectopic calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01343",
    "question": "What is associated with Abnormal size of the palpebral fissures?",
    "seeds": [
      "Abnormal size of the palpebral fissures"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01344",
    "question": "What is associated with Focal cognitive seizure with hallucination?",
    "seeds": [
      "Focal cognitive seizure with hallucination"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01345",
    "question": "What is associated with Ovarian mass?",
    "seeds": [
      "Ovarian mass"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01346",
    "question": "What is associated with Abnormality of the epiphysis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Abnormality of the epiphysis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01347",
    "question": "What is associated with Asymmetry of the breasts?",
    "seeds": [
      "Asymmetry of the breasts"
    ],
    "gold_answer": "Abnormality of the breast",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01348",
    "question": "What phenotype is associated with Pulmonary hypertension, primary, 2?",
    "seeds": [
      "Pulmonary hypertension, primary, 2"
    ],
    "gold_answer": "Increased pulmonary vascular resistance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01349",
    "question": "What is associated with Arteriosclerosis of small cerebral arteries?",
    "seeds": [
      "Arteriosclerosis of small cerebral arteries"
    ],
    "gold_answer": "Abnormal cerebral artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01350",
    "question": "What is associated with Talipes?",
    "seeds": [
      "Talipes"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01351",
    "question": "What phenotype is associated with Holoprosencephaly, semilobar, with craniosynostosis?",
    "seeds": [
      "Holoprosencephaly, semilobar, with craniosynostosis"
    ],
    "gold_answer": "Lambdoidal craniosynostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01352",
    "question": "What is associated with Dilated cardiomyopathy?",
    "seeds": [
      "Dilated cardiomyopathy"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01353",
    "question": "What is associated with Clostridium difficile colitis?",
    "seeds": [
      "Clostridium difficile colitis"
    ],
    "gold_answer": "Unusual gastrointestinal infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01354",
    "question": "What is associated with Multicentric femoral head ossification?",
    "seeds": [
      "Multicentric femoral head ossification"
    ],
    "gold_answer": "Abnormal enchondral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01355",
    "question": "What is associated with Abnormal bronchoalveolar lavage fluid morphology?",
    "seeds": [
      "Abnormal bronchoalveolar lavage fluid morphology"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01356",
    "question": "What phenotype is associated with RFT1-CDG?",
    "seeds": [
      "RFT1-CDG"
    ],
    "gold_answer": "Abnormality of the posterior cranial fossa",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01357",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 71?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 71"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01358",
    "question": "What phenotype is associated with Leber congenital amaurosis 4?",
    "seeds": [
      "Leber congenital amaurosis 4"
    ],
    "gold_answer": "Cone/cone-rod dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01359",
    "question": "What is associated with Abnormal light-adapted single flash electroretinogram?",
    "seeds": [
      "Abnormal light-adapted single flash electroretinogram"
    ],
    "gold_answer": "Abnormal light-adapted electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01360",
    "question": "What is associated with Beta-cell dysfunction?",
    "seeds": [
      "Beta-cell dysfunction"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01361",
    "question": "What is associated with Mastoiditis?",
    "seeds": [
      "Mastoiditis"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01362",
    "question": "What is associated with Growth delay due to insulin-like growth factor I resistance?",
    "seeds": [
      "Growth delay due to insulin-like growth factor I resistance"
    ],
    "gold_answer": "Abnormal sternum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01363",
    "question": "What is associated with Large vessel vasculitis?",
    "seeds": [
      "Large vessel vasculitis"
    ],
    "gold_answer": "Vasculitis by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01364",
    "question": "What phenotype is associated with Anterior segment dysgenesis 6, multiple subtypes?",
    "seeds": [
      "Anterior segment dysgenesis 6, multiple subtypes"
    ],
    "gold_answer": "Corneal opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01365",
    "question": "What is associated with Say-Barber-Miller syndrome?",
    "seeds": [
      "Say-Barber-Miller syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the mandible",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01366",
    "question": "What is associated with Reduced circulating interleukin 9 concentration?",
    "seeds": [
      "Reduced circulating interleukin 9 concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01367",
    "question": "What is associated with Increased mean corpuscular volume?",
    "seeds": [
      "Increased mean corpuscular volume"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01368",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanx of the thumb?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanx of the thumb"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01369",
    "question": "What phenotype is associated with Pierre Robin sequence with facial and digital anomalies?",
    "seeds": [
      "Pierre Robin sequence with facial and digital anomalies"
    ],
    "gold_answer": "Hyperconvex nail",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01370",
    "question": "What phenotype is associated with Glaucoma 1, open angle, M?",
    "seeds": [
      "Glaucoma 1, open angle, M"
    ],
    "gold_answer": "Constriction of peripheral visual field",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01371",
    "question": "What is associated with Unexplained fevers?",
    "seeds": [
      "Unexplained fevers"
    ],
    "gold_answer": "Abnormality of temperature regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01372",
    "question": "What is associated with Impaired neutrophil bactericidal activity?",
    "seeds": [
      "Impaired neutrophil bactericidal activity"
    ],
    "gold_answer": "Abnormal leukocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01373",
    "question": "What is associated with Anti-cytomegalovirus antibody positivity?",
    "seeds": [
      "Anti-cytomegalovirus antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01374",
    "question": "What is associated with Large earlobe?",
    "seeds": [
      "Large earlobe"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01375",
    "question": "What is associated with Parotitis?",
    "seeds": [
      "Parotitis"
    ],
    "gold_answer": "Abnormal parotid gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01376",
    "question": "What is associated with Childhood-onset Steinert myotonic dystrophy?",
    "seeds": [
      "Childhood-onset Steinert myotonic dystrophy"
    ],
    "gold_answer": "DMPK",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01377",
    "question": "What is associated with Elbow extension contracture?",
    "seeds": [
      "Elbow extension contracture"
    ],
    "gold_answer": "Limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01378",
    "question": "What is associated with Double aortic arch?",
    "seeds": [
      "Double aortic arch"
    ],
    "gold_answer": "Abnormal aortic arch morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01379",
    "question": "What is associated with Hypotrichosis simplex?",
    "seeds": [
      "Hypotrichosis simplex"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the eyebrow",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01380",
    "question": "What is associated with Unilambdoid synostosis?",
    "seeds": [
      "Unilambdoid synostosis"
    ],
    "gold_answer": "Lambdoidal craniosynostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01381",
    "question": "What is associated with Triggered by smoking?",
    "seeds": [
      "Triggered by smoking"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01382",
    "question": "What is associated with Zechi-Ceide syndrome?",
    "seeds": [
      "Zechi-Ceide syndrome"
    ],
    "gold_answer": "Tooth agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01383",
    "question": "What is associated with Nodular goiter?",
    "seeds": [
      "Nodular goiter"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01384",
    "question": "What is associated with Synostosis involving bones of the lower limbs?",
    "seeds": [
      "Synostosis involving bones of the lower limbs"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01385",
    "question": "What is associated with Absent vertebra?",
    "seeds": [
      "Absent vertebra"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01386",
    "question": "What is associated with Cutis laxa, autosomal recessive, type IIE?",
    "seeds": [
      "Cutis laxa, autosomal recessive, type IIE"
    ],
    "gold_answer": "Abnormality of the palmar creases",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01387",
    "question": "What phenotype is associated with Familial exudative vitreoretinopathy?",
    "seeds": [
      "Familial exudative vitreoretinopathy"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01388",
    "question": "What is associated with Metaphyseal chondrodysplasia?",
    "seeds": [
      "Metaphyseal chondrodysplasia"
    ],
    "gold_answer": "Metaphyseal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01389",
    "question": "What phenotype is associated with Carey-Fineman-Ziter syndrome 2?",
    "seeds": [
      "Carey-Fineman-Ziter syndrome 2"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01390",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia, aggrecan type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, aggrecan type"
    ],
    "gold_answer": "Abnormal nasal bridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01391",
    "question": "What phenotype is associated with Myofibrillar myopathy 11?",
    "seeds": [
      "Myofibrillar myopathy 11"
    ],
    "gold_answer": "Underdeveloped supraorbital ridges",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01392",
    "question": "What is associated with Focal aware cognitive seizure with neglect?",
    "seeds": [
      "Focal aware cognitive seizure with neglect"
    ],
    "gold_answer": "Focal cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01393",
    "question": "What is associated with Neurocutaneous melanocytosis?",
    "seeds": [
      "Neurocutaneous melanocytosis"
    ],
    "gold_answer": "Abnormal chorioretinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01394",
    "question": "What phenotype is associated with Faciodigitogenital syndrome, autosomal recessive?",
    "seeds": [
      "Faciodigitogenital syndrome, autosomal recessive"
    ],
    "gold_answer": "Attention deficit hyperactivity disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01395",
    "question": "What is associated with Ichthyosis-Cheek-Eyebrow syndrome?",
    "seeds": [
      "Ichthyosis-Cheek-Eyebrow syndrome"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01396",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 3, with or without situs inversus?",
    "seeds": [
      "Ciliary dyskinesia, primary, 3, with or without situs inversus"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01397",
    "question": "What is associated with Focal aware cognitive seizure with dyscalculia/acalculia?",
    "seeds": [
      "Focal aware cognitive seizure with dyscalculia/acalculia"
    ],
    "gold_answer": "Focal aware seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01398",
    "question": "What is associated with Hypoplastic femurs and pelvis?",
    "seeds": [
      "Hypoplastic femurs and pelvis"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01399",
    "question": "What is associated with Ciliary dyskinesia, primary, 14?",
    "seeds": [
      "Ciliary dyskinesia, primary, 14"
    ],
    "gold_answer": "CFAP53",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01400",
    "question": "What is associated with Ivory epiphysis of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Ivory epiphysis of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Sclerosis of 5th finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01401",
    "question": "What is associated with Abnormality of the urethra?",
    "seeds": [
      "Abnormality of the urethra"
    ],
    "gold_answer": "Abnormality of the urinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01402",
    "question": "What is associated with Recurrent viral pneumonia?",
    "seeds": [
      "Recurrent viral pneumonia"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01403",
    "question": "What is associated with Imprinted?",
    "seeds": [
      "Imprinted"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01404",
    "question": "What is associated with Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism?",
    "seeds": [
      "Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism"
    ],
    "gold_answer": "Decreased circulating gonadotropin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01405",
    "question": "What is associated with Lymphedema, primary, with myelodysplasia?",
    "seeds": [
      "Lymphedema, primary, with myelodysplasia"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01406",
    "question": "What is associated with Renal arteriole intima/media crystal accumulation?",
    "seeds": [
      "Renal arteriole intima/media crystal accumulation"
    ],
    "gold_answer": "Abnormal renal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01407",
    "question": "What is associated with Medially sloping radial epiphyses?",
    "seeds": [
      "Medially sloping radial epiphyses"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01408",
    "question": "What is associated with Chromosome 15q26-qter deletion syndrome?",
    "seeds": [
      "Chromosome 15q26-qter deletion syndrome"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01409",
    "question": "What is associated with Upper limb muscle hypoplasia?",
    "seeds": [
      "Upper limb muscle hypoplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the musculature of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01410",
    "question": "What is associated with Partial duplication of eyebrows?",
    "seeds": [
      "Partial duplication of eyebrows"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01411",
    "question": "What is associated with Lissencephaly?",
    "seeds": [
      "Lissencephaly"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01412",
    "question": "What phenotype is associated with Hyperlipoproteinemia, type V?",
    "seeds": [
      "Hyperlipoproteinemia, type V"
    ],
    "gold_answer": "Increased circulating chylomicron concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01413",
    "question": "What is associated with Autonomic-voluntary dissociation of facial movements?",
    "seeds": [
      "Autonomic-voluntary dissociation of facial movements"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01414",
    "question": "What is associated with Hypogonadotropic hypogonadism?",
    "seeds": [
      "Hypogonadotropic hypogonadism"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01415",
    "question": "What is associated with Cowden syndrome 7?",
    "seeds": [
      "Cowden syndrome 7"
    ],
    "gold_answer": "Intestinal polyp",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01416",
    "question": "What is associated with Hermansky-Pudlak syndrome 6?",
    "seeds": [
      "Hermansky-Pudlak syndrome 6"
    ],
    "gold_answer": "Abnormal pharynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01417",
    "question": "What is associated with Restless legs syndrome, susceptibility to, 1?",
    "seeds": [
      "Restless legs syndrome, susceptibility to, 1"
    ],
    "gold_answer": "Akathisia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01418",
    "question": "What is associated with Hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities?",
    "seeds": [
      "Hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01419",
    "question": "What phenotype is associated with Hypercholanemia, familial?",
    "seeds": [
      "Hypercholanemia, familial"
    ],
    "gold_answer": "Fat malabsorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01420",
    "question": "What is associated with Fractured distal epiphysis of distal phalanx of manual digit 1?",
    "seeds": [
      "Fractured distal epiphysis of distal phalanx of manual digit 1"
    ],
    "gold_answer": "Fragmentation of the epiphyses of the distal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01421",
    "question": "What is associated with Hemihypertrophy of lower limb?",
    "seeds": [
      "Hemihypertrophy of lower limb"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01422",
    "question": "What is associated with Glycogen storage disease due to phosphoglycerate kinase 1 deficiency?",
    "seeds": [
      "Glycogen storage disease due to phosphoglycerate kinase 1 deficiency"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01423",
    "question": "What is associated with Ring fibers?",
    "seeds": [
      "Ring fibers"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01424",
    "question": "What is associated with Palmar warts?",
    "seeds": [
      "Palmar warts"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01425",
    "question": "What is associated with Abnormal corticospinal tract morphology?",
    "seeds": [
      "Abnormal corticospinal tract morphology"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01426",
    "question": "What is associated with Triggered by fasting?",
    "seeds": [
      "Triggered by fasting"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01427",
    "question": "What is associated with Panhypopituitarism?",
    "seeds": [
      "Panhypopituitarism"
    ],
    "gold_answer": "Anterior hypopituitarism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01428",
    "question": "What is associated with Glioblastoma?",
    "seeds": [
      "Glioblastoma"
    ],
    "gold_answer": "Neuroepithelial neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01429",
    "question": "What is associated with Complete duplication of the distal phalanx of the 4th finger?",
    "seeds": [
      "Complete duplication of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Complete duplication of the distal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01430",
    "question": "What is associated with Intellectual developmental disorder with or without epilepsy or cerebellar ataxia?",
    "seeds": [
      "Intellectual developmental disorder with or without epilepsy or cerebellar ataxia"
    ],
    "gold_answer": "Personality disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01431",
    "question": "What is associated with Episodic hyperhidrosis?",
    "seeds": [
      "Episodic hyperhidrosis"
    ],
    "gold_answer": "Hypohidrosis or hyperhidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01432",
    "question": "What is associated with Frontofacionasal dysplasia?",
    "seeds": [
      "Frontofacionasal dysplasia"
    ],
    "gold_answer": "Abnormal periauricular region morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01433",
    "question": "What is associated with Lymph-node hemophagocytosis?",
    "seeds": [
      "Lymph-node hemophagocytosis"
    ],
    "gold_answer": "Hemophagocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01434",
    "question": "What is associated with Abnormal parotid gland morphology?",
    "seeds": [
      "Abnormal parotid gland morphology"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01435",
    "question": "What is associated with Spinal dysraphism?",
    "seeds": [
      "Spinal dysraphism"
    ],
    "gold_answer": "Neural tube defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01436",
    "question": "What is associated with Increased circulating N-acetylaspartic acid concentration?",
    "seeds": [
      "Increased circulating N-acetylaspartic acid concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01437",
    "question": "What phenotype is associated with Arterial calcification, generalized, of infancy, 1?",
    "seeds": [
      "Arterial calcification, generalized, of infancy, 1"
    ],
    "gold_answer": "Myocardial infarction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01438",
    "question": "What phenotype is associated with Mitochondrial pyruvate carrier deficiency?",
    "seeds": [
      "Mitochondrial pyruvate carrier deficiency"
    ],
    "gold_answer": "Progressive microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01439",
    "question": "What phenotype is associated with Pseudohypoaldosteronism, type IIC?",
    "seeds": [
      "Pseudohypoaldosteronism, type IIC"
    ],
    "gold_answer": "Metabolic acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01440",
    "question": "What is associated with Methylmalonic aciduria and homocystinuria, cblC type?",
    "seeds": [
      "Methylmalonic aciduria and homocystinuria, cblC type"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01441",
    "question": "What is associated with Delayed ability to stand?",
    "seeds": [
      "Delayed ability to stand"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01442",
    "question": "What is associated with Rectourethral fistula?",
    "seeds": [
      "Rectourethral fistula"
    ],
    "gold_answer": "Rectal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01443",
    "question": "What is associated with EEG with central sharp waves?",
    "seeds": [
      "EEG with central sharp waves"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01444",
    "question": "What phenotype is associated with Hypoglossia with situs inversus?",
    "seeds": [
      "Hypoglossia with situs inversus"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01445",
    "question": "What is associated with Polyneuropathy?",
    "seeds": [
      "Polyneuropathy"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01446",
    "question": "What phenotype is associated with Pseudoxanthomatous diffuse cutaneous mastocytosis?",
    "seeds": [
      "Pseudoxanthomatous diffuse cutaneous mastocytosis"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01447",
    "question": "What is associated with Central heterochromia?",
    "seeds": [
      "Central heterochromia"
    ],
    "gold_answer": "Abnormal iris pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01448",
    "question": "What is associated with Congenital laryngeal stridor?",
    "seeds": [
      "Congenital laryngeal stridor"
    ],
    "gold_answer": "Stridor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01449",
    "question": "What is associated with Narrow forehead?",
    "seeds": [
      "Narrow forehead"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01450",
    "question": "What is associated with Alzheimer disease-4?",
    "seeds": [
      "Alzheimer disease-4"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01451",
    "question": "What is associated with Anti-FGFR3 antibody positivity?",
    "seeds": [
      "Anti-FGFR3 antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01452",
    "question": "What is associated with Periventricular cysts?",
    "seeds": [
      "Periventricular cysts"
    ],
    "gold_answer": "Abnormal periventricular white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01453",
    "question": "What is associated with Absent sternal ossification?",
    "seeds": [
      "Absent sternal ossification"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the sternum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01454",
    "question": "What is associated with Fixed head retroflexion?",
    "seeds": [
      "Fixed head retroflexion"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01455",
    "question": "What is associated with Anorectal stricture?",
    "seeds": [
      "Anorectal stricture"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01456",
    "question": "What is associated with Popliteal pterygium syndrome?",
    "seeds": [
      "Popliteal pterygium syndrome"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01457",
    "question": "What is associated with Dilatation of the ductus arteriosus?",
    "seeds": [
      "Dilatation of the ductus arteriosus"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01458",
    "question": "What is associated with Hemoglobin Lepore-beta-thalassemia intermedia?",
    "seeds": [
      "Hemoglobin Lepore-beta-thalassemia intermedia"
    ],
    "gold_answer": "HBB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_01459",
    "question": "What is associated with Subependymal nodular heterotopia?",
    "seeds": [
      "Subependymal nodular heterotopia"
    ],
    "gold_answer": "Frontoethmoidal encephalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01460",
    "question": "What phenotype is associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome 4?",
    "seeds": [
      "Megacystis-microcolon-intestinal hypoperistalsis syndrome 4"
    ],
    "gold_answer": "Megacystis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01461",
    "question": "What is associated with Infantile epileptic spasms syndrome?",
    "seeds": [
      "Infantile epileptic spasms syndrome"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01462",
    "question": "What is associated with Curved 4th toe phalanx?",
    "seeds": [
      "Curved 4th toe phalanx"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01463",
    "question": "What is associated with Abnormal blood chloride concentration?",
    "seeds": [
      "Abnormal blood chloride concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01464",
    "question": "What is associated with Leber congenital amaurosis-3 (LCA3)/Retinitis pigmentosa, juvenile, autosomal recessive?",
    "seeds": [
      "Leber congenital amaurosis-3 (LCA3)/Retinitis pigmentosa, juvenile, autosomal recessive"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01465",
    "question": "What phenotype is associated with Osteopetrosis, autosomal dominant 1?",
    "seeds": [
      "Osteopetrosis, autosomal dominant 1"
    ],
    "gold_answer": "Elevated serum acid phosphatase",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01466",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 5?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 5"
    ],
    "gold_answer": "Abnormal neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01467",
    "question": "What is associated with Pulmonary lymphangiectasia?",
    "seeds": [
      "Pulmonary lymphangiectasia"
    ],
    "gold_answer": "Abnormal pulmonary lymphatics",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01468",
    "question": "What is associated with Allesthesia?",
    "seeds": [
      "Allesthesia"
    ],
    "gold_answer": "Disturbed sensory perception",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01469",
    "question": "What is associated with Diaphragmatic weakness?",
    "seeds": [
      "Diaphragmatic weakness"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01470",
    "question": "What is associated with Iris transillumination defect?",
    "seeds": [
      "Iris transillumination defect"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01471",
    "question": "What is associated with PPARG-associated congenital generalized lipodystrophy?",
    "seeds": [
      "PPARG-associated congenital generalized lipodystrophy"
    ],
    "gold_answer": "PPARG",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01472",
    "question": "What is associated with Deafness, autosomal recessive 1A?",
    "seeds": [
      "Deafness, autosomal recessive 1A"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01473",
    "question": "What is associated with Decreased muscle glycogen content?",
    "seeds": [
      "Decreased muscle glycogen content"
    ],
    "gold_answer": "Abnormal muscle glycogen content",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01474",
    "question": "What phenotype is associated with Cartilage-hair hypoplasia?",
    "seeds": [
      "Cartilage-hair hypoplasia"
    ],
    "gold_answer": "Malabsorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01475",
    "question": "What is associated with Anhydramnios?",
    "seeds": [
      "Anhydramnios"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01476",
    "question": "What is associated with Substantially elevated circulating ethanol concentration?",
    "seeds": [
      "Substantially elevated circulating ethanol concentration"
    ],
    "gold_answer": "Blood xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01477",
    "question": "What is associated with Hypophosphatemic rickets?",
    "seeds": [
      "Hypophosphatemic rickets"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01478",
    "question": "What is associated with Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency?",
    "seeds": [
      "Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency"
    ],
    "gold_answer": "MCM4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01479",
    "question": "What is associated with Ocular anomalies-axonal neuropathy-developmental delay syndrome?",
    "seeds": [
      "Ocular anomalies-axonal neuropathy-developmental delay syndrome"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01480",
    "question": "What is associated with Ceroid lipofuscinosis, neuronal, 3?",
    "seeds": [
      "Ceroid lipofuscinosis, neuronal, 3"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01481",
    "question": "What phenotype is associated with PAGOD syndrome?",
    "seeds": [
      "PAGOD syndrome"
    ],
    "gold_answer": "Restrictive ventilatory defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01482",
    "question": "What is associated with Reduced phosphoserine phosphatase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced phosphoserine phosphatase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01483",
    "question": "What is associated with Lymphangiectasia, pulmonary, congenital?",
    "seeds": [
      "Lymphangiectasia, pulmonary, congenital"
    ],
    "gold_answer": "Hydrops fetalis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01484",
    "question": "What is associated with Idiopathic steroid-sensitive nephrotic syndrome?",
    "seeds": [
      "Idiopathic steroid-sensitive nephrotic syndrome"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01485",
    "question": "What is associated with Abnormal microglia morphology?",
    "seeds": [
      "Abnormal microglia morphology"
    ],
    "gold_answer": "Abnormal glial cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01486",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 20?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 20"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01487",
    "question": "What is associated with Exacerbated by pronation?",
    "seeds": [
      "Exacerbated by pronation"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01488",
    "question": "What is associated with Thakker-Donnai syndrome?",
    "seeds": [
      "Thakker-Donnai syndrome"
    ],
    "gold_answer": "Abnormal renal pelvis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01489",
    "question": "What phenotype is associated with Kaposi sarcoma, susceptibility to?",
    "seeds": [
      "Kaposi sarcoma, susceptibility to"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01490",
    "question": "What is associated with Contracture of the distal interphalangeal joint of the fingers?",
    "seeds": [
      "Contracture of the distal interphalangeal joint of the fingers"
    ],
    "gold_answer": "Finger joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01491",
    "question": "What is associated with Ovarian dermoid cyst?",
    "seeds": [
      "Ovarian dermoid cyst"
    ],
    "gold_answer": "Ovarian teratoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01492",
    "question": "What phenotype is associated with Frontotemporal dementia and/or amytrophic lateral sclerosis 7?",
    "seeds": [
      "Frontotemporal dementia and/or amytrophic lateral sclerosis 7"
    ],
    "gold_answer": "Mutism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01493",
    "question": "What phenotype is associated with Hypomelanosis of Ito?",
    "seeds": [
      "Hypomelanosis of Ito"
    ],
    "gold_answer": "Iris coloboma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01494",
    "question": "What is associated with Thickened cortex of the clavicle?",
    "seeds": [
      "Thickened cortex of the clavicle"
    ],
    "gold_answer": "Abnormal clavicle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01495",
    "question": "What is associated with Immunodeficiency 114, folate-responsive?",
    "seeds": [
      "Immunodeficiency 114, folate-responsive"
    ],
    "gold_answer": "Eczematoid dermatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01496",
    "question": "What is associated with Aplasia/Hypoplasia involving the musculature of the upper limbs?",
    "seeds": [
      "Aplasia/Hypoplasia involving the musculature of the upper limbs"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the skeletal musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01497",
    "question": "What is associated with Autoinflammation and autoimmunity, systemic, with immune dysregulation 2?",
    "seeds": [
      "Autoinflammation and autoimmunity, systemic, with immune dysregulation 2"
    ],
    "gold_answer": "Abnormal blood monovalent inorganic cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01498",
    "question": "What phenotype is associated with Microcephaly, congenital heart disease, unilateral renal agenesis,and hyposegmented lungs?",
    "seeds": [
      "Microcephaly, congenital heart disease, unilateral renal agenesis,and hyposegmented lungs"
    ],
    "gold_answer": "Cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01499",
    "question": "What phenotype is associated with Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency?",
    "seeds": [
      "Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency"
    ],
    "gold_answer": "Increased circulating androstenedione concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01500",
    "question": "What is associated with Visual field defect?",
    "seeds": [
      "Visual field defect"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01501",
    "question": "What is associated with Periodic limb movements of sleep?",
    "seeds": [
      "Periodic limb movements of sleep"
    ],
    "gold_answer": "Parasomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01502",
    "question": "What is associated with Abnormality of the epiphysis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Abnormality of the epiphysis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal fourth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01503",
    "question": "What phenotype is associated with Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4"
    ],
    "gold_answer": "Dandy-Walker malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01504",
    "question": "What is associated with Salla disease?",
    "seeds": [
      "Salla disease"
    ],
    "gold_answer": "Exodeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01505",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 14?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 14"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01506",
    "question": "What phenotype is associated with Hypercholesterolemia, familial, 2?",
    "seeds": [
      "Hypercholesterolemia, familial, 2"
    ],
    "gold_answer": "Xanthelasma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01507",
    "question": "What is associated with Renal tubular epithelial necrosis?",
    "seeds": [
      "Renal tubular epithelial necrosis"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01508",
    "question": "What is associated with Vascular dilatation?",
    "seeds": [
      "Vascular dilatation"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01509",
    "question": "What is associated with Compensatory head tilt to the left shoulder?",
    "seeds": [
      "Compensatory head tilt to the left shoulder"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01510",
    "question": "What is associated with Absent muscle fiber delta sarcoglycan?",
    "seeds": [
      "Absent muscle fiber delta sarcoglycan"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01511",
    "question": "What is associated with Cyanide-induced parkinsonism-dystonia?",
    "seeds": [
      "Cyanide-induced parkinsonism-dystonia"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01512",
    "question": "What is associated with Abnormal geniohyoid muscle morphology?",
    "seeds": [
      "Abnormal geniohyoid muscle morphology"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01513",
    "question": "What is associated with Atrophodermia vermiculata?",
    "seeds": [
      "Atrophodermia vermiculata"
    ],
    "gold_answer": "Abnormality of facial soft tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01514",
    "question": "What phenotype is associated with Müllerian duct anomalies-limb anomalies syndrome?",
    "seeds": [
      "Müllerian duct anomalies-limb anomalies syndrome"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01515",
    "question": "What is associated with Pancolitis?",
    "seeds": [
      "Pancolitis"
    ],
    "gold_answer": "Inflammation of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01516",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2D?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2D"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01517",
    "question": "What is associated with Galactose epimerase deficiency?",
    "seeds": [
      "Galactose epimerase deficiency"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01518",
    "question": "What is associated with Leukodystrophy, childhood-onset, remitting?",
    "seeds": [
      "Leukodystrophy, childhood-onset, remitting"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01519",
    "question": "What is associated with Increased CD21low B cell proportion?",
    "seeds": [
      "Increased CD21low B cell proportion"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01520",
    "question": "What is associated with Lumbar scoliosis?",
    "seeds": [
      "Lumbar scoliosis"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01521",
    "question": "What is associated with Occupational disability?",
    "seeds": [
      "Occupational disability"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01522",
    "question": "What is associated with Glomerular basement membrane subendothelial remodeling?",
    "seeds": [
      "Glomerular basement membrane subendothelial remodeling"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01523",
    "question": "What is associated with Frontal venous angioma?",
    "seeds": [
      "Frontal venous angioma"
    ],
    "gold_answer": "Cerebral venous angioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01524",
    "question": "What is associated with Nephrogenic diabetes insipidus?",
    "seeds": [
      "Nephrogenic diabetes insipidus"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01525",
    "question": "What phenotype is associated with Nablus mask-like facial syndrome?",
    "seeds": [
      "Nablus mask-like facial syndrome"
    ],
    "gold_answer": "Narrow forehead",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01526",
    "question": "What phenotype is associated with Autosomal recessive hypohidrotic ectodermal dysplasia?",
    "seeds": [
      "Autosomal recessive hypohidrotic ectodermal dysplasia"
    ],
    "gold_answer": "Premature loss of primary teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01527",
    "question": "What is associated with Femoral nerve distribution?",
    "seeds": [
      "Femoral nerve distribution"
    ],
    "gold_answer": "Localized",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01528",
    "question": "What is associated with Facial palsy, familial recurrent peripheral?",
    "seeds": [
      "Facial palsy, familial recurrent peripheral"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01529",
    "question": "What is associated with Reduced co-speech gestures?",
    "seeds": [
      "Reduced co-speech gestures"
    ],
    "gold_answer": "Abnormal cognitive process",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01530",
    "question": "What is associated with Pancreatic squamous cell carcinoma?",
    "seeds": [
      "Pancreatic squamous cell carcinoma"
    ],
    "gold_answer": "Neoplasm of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01531",
    "question": "What is associated with Dwarfism, low-birth-weight type, with unresponsiveness to growth hormone?",
    "seeds": [
      "Dwarfism, low-birth-weight type, with unresponsiveness to growth hormone"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01532",
    "question": "What is associated with Reduced production of gestures?",
    "seeds": [
      "Reduced production of gestures"
    ],
    "gold_answer": "Abnormal nonverbal communicative behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01533",
    "question": "What is associated with Recent history of caustic substance ingestion?",
    "seeds": [
      "Recent history of caustic substance ingestion"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01534",
    "question": "What is associated with Muscle filaminopathy?",
    "seeds": [
      "Muscle filaminopathy"
    ],
    "gold_answer": "Abnormal circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01535",
    "question": "What is associated with Focal impaired awareness manual automatism seizure?",
    "seeds": [
      "Focal impaired awareness manual automatism seizure"
    ],
    "gold_answer": "Focal manual automatism seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01536",
    "question": "What phenotype is associated with Arterial tortuosity syndrome?",
    "seeds": [
      "Arterial tortuosity syndrome"
    ],
    "gold_answer": "Pulmonary artery stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01537",
    "question": "What phenotype is associated with Lissencephaly due to LIS1 mutation?",
    "seeds": [
      "Lissencephaly due to LIS1 mutation"
    ],
    "gold_answer": "Atonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01538",
    "question": "What is associated with Pyridoxine-responsive sideroblastic anemia?",
    "seeds": [
      "Pyridoxine-responsive sideroblastic anemia"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01539",
    "question": "What is associated with Bursa fluid crystals?",
    "seeds": [
      "Bursa fluid crystals"
    ],
    "gold_answer": "Abnormal synovial bursa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01540",
    "question": "What is associated with Coronary artery fistula?",
    "seeds": [
      "Coronary artery fistula"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01541",
    "question": "What phenotype is associated with Fibromatosis, gingival, with progressive deafness?",
    "seeds": [
      "Fibromatosis, gingival, with progressive deafness"
    ],
    "gold_answer": "Gingival fibromatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01542",
    "question": "What is associated with Acrofacial dysostosis 1, Nager type?",
    "seeds": [
      "Acrofacial dysostosis 1, Nager type"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01543",
    "question": "What is associated with Hand paresthesia?",
    "seeds": [
      "Hand paresthesia"
    ],
    "gold_answer": "Paresthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01544",
    "question": "What is associated with Broad neck?",
    "seeds": [
      "Broad neck"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01545",
    "question": "What is associated with Focal sensory seizure?",
    "seeds": [
      "Focal sensory seizure"
    ],
    "gold_answer": "Non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01546",
    "question": "What is associated with Eschar?",
    "seeds": [
      "Eschar"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01547",
    "question": "What is associated with Splenic calcification?",
    "seeds": [
      "Splenic calcification"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01548",
    "question": "What is associated with Red skin pigment anomaly of new guinea?",
    "seeds": [
      "Red skin pigment anomaly of new guinea"
    ],
    "gold_answer": "Sensory hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01549",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 6 (Dravet syndrome)?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 6 (Dravet syndrome)"
    ],
    "gold_answer": "Generalized clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01550",
    "question": "What is associated with Infantile spasms?",
    "seeds": [
      "Infantile spasms"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01551",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 65?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 65"
    ],
    "gold_answer": "Thin eyebrow",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01552",
    "question": "What is associated with Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration?",
    "seeds": [
      "Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration"
    ],
    "gold_answer": "Long-tract sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01553",
    "question": "What is associated with Abnormal CSF albumin concentration?",
    "seeds": [
      "Abnormal CSF albumin concentration"
    ],
    "gold_answer": "Abnormal CSF protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01554",
    "question": "What is associated with Chondromyxoid fibroma?",
    "seeds": [
      "Chondromyxoid fibroma"
    ],
    "gold_answer": "GRM1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_01555",
    "question": "What phenotype is associated with Silver-Russell syndrome due to 11p15 microduplication?",
    "seeds": [
      "Silver-Russell syndrome due to 11p15 microduplication"
    ],
    "gold_answer": "Intrauterine growth retardation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01556",
    "question": "What is associated with Hypobetalipoproteinemia, familial, 1?",
    "seeds": [
      "Hypobetalipoproteinemia, familial, 1"
    ],
    "gold_answer": "Elevated circulating hepatic transaminase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01557",
    "question": "What is associated with Positive Neisseria gonorrhoeae urine nucleic acid test?",
    "seeds": [
      "Positive Neisseria gonorrhoeae urine nucleic acid test"
    ],
    "gold_answer": "Positive urine infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01558",
    "question": "What is associated with Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2?",
    "seeds": [
      "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01559",
    "question": "What is associated with Abnormality of von Willebrand factor?",
    "seeds": [
      "Abnormality of von Willebrand factor"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01560",
    "question": "What is associated with Severe lactic acidosis?",
    "seeds": [
      "Severe lactic acidosis"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01561",
    "question": "What phenotype is associated with Aprosencephaly syndrome?",
    "seeds": [
      "Aprosencephaly syndrome"
    ],
    "gold_answer": "Spina bifida",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01562",
    "question": "What is associated with Endocardial fibroelastosis?",
    "seeds": [
      "Endocardial fibroelastosis"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01563",
    "question": "What phenotype is associated with Congenital tricuspid valve dysplasia?",
    "seeds": [
      "Congenital tricuspid valve dysplasia"
    ],
    "gold_answer": "Tricuspid regurgitation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01564",
    "question": "What phenotype is associated with Asthma, susceptibility to?",
    "seeds": [
      "Asthma, susceptibility to"
    ],
    "gold_answer": "Asthma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01565",
    "question": "What is associated with Immunodeficiency due to a classical component pathway complement deficiency?",
    "seeds": [
      "Immunodeficiency due to a classical component pathway complement deficiency"
    ],
    "gold_answer": "C2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01566",
    "question": "What is associated with Decreased pre-bronchodilator forced expiratory flow 25-75%?",
    "seeds": [
      "Decreased pre-bronchodilator forced expiratory flow 25-75%"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01567",
    "question": "What is associated with Aplasia/hypoplasia of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Aplasia/hypoplasia of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01568",
    "question": "What is associated with Panacinar emphysema?",
    "seeds": [
      "Panacinar emphysema"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01569",
    "question": "What is associated with Immunodeficiency 54?",
    "seeds": [
      "Immunodeficiency 54"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01570",
    "question": "What is associated with Macular drusen?",
    "seeds": [
      "Macular drusen"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01571",
    "question": "What phenotype is associated with Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities"
    ],
    "gold_answer": "Short neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01572",
    "question": "What phenotype is associated with Tangier disease?",
    "seeds": [
      "Tangier disease"
    ],
    "gold_answer": "Coronary artery atherosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01573",
    "question": "What is associated with Vasovagal syncope?",
    "seeds": [
      "Vasovagal syncope"
    ],
    "gold_answer": "Loss of consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01574",
    "question": "What is associated with Thin toenail?",
    "seeds": [
      "Thin toenail"
    ],
    "gold_answer": "Abnormal toenail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01575",
    "question": "What is associated with Autoamputation?",
    "seeds": [
      "Autoamputation"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01576",
    "question": "What is associated with Abnormal glycosidase enzyme activity?",
    "seeds": [
      "Abnormal glycosidase enzyme activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01577",
    "question": "What is associated with Hyperphosphatasia with impaired intellectual development syndrome 3?",
    "seeds": [
      "Hyperphosphatasia with impaired intellectual development syndrome 3"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01578",
    "question": "What is associated with Cerebrooculofacioskeletal syndrome 3?",
    "seeds": [
      "Cerebrooculofacioskeletal syndrome 3"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01579",
    "question": "What phenotype is associated with Cardiomyopathy, familial hypertrophic, 28?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 28"
    ],
    "gold_answer": "Systolic anterior motion of the mitral valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01580",
    "question": "What is associated with Buttock pain?",
    "seeds": [
      "Buttock pain"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01581",
    "question": "What is associated with Thrombophilia due to decreased release of tissue plasminogen?",
    "seeds": [
      "Thrombophilia due to decreased release of tissue plasminogen"
    ],
    "gold_answer": "Deep venous thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01582",
    "question": "What is associated with Abnormal corticospinal tract morphology?",
    "seeds": [
      "Abnormal corticospinal tract morphology"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01583",
    "question": "What is associated with Postaxial polydactyly type A?",
    "seeds": [
      "Postaxial polydactyly type A"
    ],
    "gold_answer": "Postaxial polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01584",
    "question": "What phenotype is associated with HYPERTENSION, DIASTOLIC, RESISTANCE TO?",
    "seeds": [
      "HYPERTENSION, DIASTOLIC, RESISTANCE TO"
    ],
    "gold_answer": "Elevated diastolic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01585",
    "question": "What is associated with Pearson syndrome?",
    "seeds": [
      "Pearson syndrome"
    ],
    "gold_answer": "Glucose intolerance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01586",
    "question": "What phenotype is associated with Yellow nail syndrome?",
    "seeds": [
      "Yellow nail syndrome"
    ],
    "gold_answer": "Yellow nails",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01587",
    "question": "What is associated with Cutaneous atresia of the external auditory canal?",
    "seeds": [
      "Cutaneous atresia of the external auditory canal"
    ],
    "gold_answer": "Atresia of the external auditory canal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01588",
    "question": "What is associated with Cystic echinococcosis?",
    "seeds": [
      "Cystic echinococcosis"
    ],
    "gold_answer": "Abnormal circulating bilirubin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01589",
    "question": "What is associated with Bone arteriovenous malformation?",
    "seeds": [
      "Bone arteriovenous malformation"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01590",
    "question": "What is associated with Abnormal earlobe morphology?",
    "seeds": [
      "Abnormal earlobe morphology"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01591",
    "question": "What is associated with Ichthyosis, congenital, autosomal recessive 10?",
    "seeds": [
      "Ichthyosis, congenital, autosomal recessive 10"
    ],
    "gold_answer": "Palmar hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01592",
    "question": "What phenotype is associated with Neurodegeneration with brain iron accumulation 3?",
    "seeds": [
      "Neurodegeneration with brain iron accumulation 3"
    ],
    "gold_answer": "Micrographia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01593",
    "question": "What is associated with Dry hair?",
    "seeds": [
      "Dry hair"
    ],
    "gold_answer": "Abnormality of hair texture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01594",
    "question": "What is associated with Rickets?",
    "seeds": [
      "Rickets"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01595",
    "question": "What is associated with Morimoto-Ryu-Malicdan neuromuscular syndrome?",
    "seeds": [
      "Morimoto-Ryu-Malicdan neuromuscular syndrome"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01596",
    "question": "What is associated with Decreased circulating complement factor I concentration?",
    "seeds": [
      "Decreased circulating complement factor I concentration"
    ],
    "gold_answer": "Reduced circulating complement concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01597",
    "question": "What is associated with Staring gaze?",
    "seeds": [
      "Staring gaze"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01598",
    "question": "What is associated with Echogenic fetal bowel?",
    "seeds": [
      "Echogenic fetal bowel"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01599",
    "question": "What is associated with Anonychia congenita totalis?",
    "seeds": [
      "Anonychia congenita totalis"
    ],
    "gold_answer": "RSPO4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01600",
    "question": "What is associated with Precocious atherosclerosis?",
    "seeds": [
      "Precocious atherosclerosis"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01601",
    "question": "What is associated with Abnormal renal tubular resorption?",
    "seeds": [
      "Abnormal renal tubular resorption"
    ],
    "gold_answer": "Renal tubular dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01602",
    "question": "What is associated with Abnormality of Krebs cycle metabolism?",
    "seeds": [
      "Abnormality of Krebs cycle metabolism"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01603",
    "question": "What is associated with Flared, irregular rib ends?",
    "seeds": [
      "Flared, irregular rib ends"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01604",
    "question": "What is associated with Charge-Like syndrome, X-linked?",
    "seeds": [
      "Charge-Like syndrome, X-linked"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01605",
    "question": "What is associated with Small epiphysis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Small epiphysis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01606",
    "question": "What is associated with Positive Blastomyces dermatitidis sputum fungal stain?",
    "seeds": [
      "Positive Blastomyces dermatitidis sputum fungal stain"
    ],
    "gold_answer": "Positive respiratory tract infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01607",
    "question": "What is associated with Cataract-microcornea syndrome?",
    "seeds": [
      "Cataract-microcornea syndrome"
    ],
    "gold_answer": "Abnormality of refraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01608",
    "question": "What phenotype is associated with Joubert syndrome with ocular defect?",
    "seeds": [
      "Joubert syndrome with ocular defect"
    ],
    "gold_answer": "Webbed neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01609",
    "question": "What is associated with Duplication of the middle phalanx of the 5th toe?",
    "seeds": [
      "Duplication of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the middle phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01610",
    "question": "What is associated with Anterior open-bite malocclusion?",
    "seeds": [
      "Anterior open-bite malocclusion"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01611",
    "question": "What is associated with Abdominal pain?",
    "seeds": [
      "Abdominal pain"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01612",
    "question": "What is associated with Prostaglandin E1 exposure?",
    "seeds": [
      "Prostaglandin E1 exposure"
    ],
    "gold_answer": "Medication history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01613",
    "question": "What is associated with Ameliorated by exposure to medication?",
    "seeds": [
      "Ameliorated by exposure to medication"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01614",
    "question": "What is associated with Hypovalinemia?",
    "seeds": [
      "Hypovalinemia"
    ],
    "gold_answer": "Abnormal circulating branched chain amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01615",
    "question": "What is associated with Angiocentric glioma?",
    "seeds": [
      "Angiocentric glioma"
    ],
    "gold_answer": "MYB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_01616",
    "question": "What is associated with Reduced N-acetylgalactosamine-6-sulfatase in cultured fibroblasts?",
    "seeds": [
      "Reduced N-acetylgalactosamine-6-sulfatase in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal enzyme activity in cultured fibroblasts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01617",
    "question": "What is associated with Renal papillary necrosis?",
    "seeds": [
      "Renal papillary necrosis"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01618",
    "question": "What is associated with Triggered by infection?",
    "seeds": [
      "Triggered by infection"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01619",
    "question": "What phenotype is associated with Nievergelt syndrome?",
    "seeds": [
      "Nievergelt syndrome"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01620",
    "question": "What phenotype is associated with Combined oxidative phosphorylation deficiency 37?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 37"
    ],
    "gold_answer": "Chorioretinal hyperpigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01621",
    "question": "What is associated with Intercostal muscle weakness?",
    "seeds": [
      "Intercostal muscle weakness"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01622",
    "question": "What is associated with Pyloric atresia?",
    "seeds": [
      "Pyloric atresia"
    ],
    "gold_answer": "Abnormality of the amniotic fluid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01623",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism"
    ],
    "gold_answer": "Conical incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01624",
    "question": "What is associated with Polycystic liver disease 3 with or without kidney cysts?",
    "seeds": [
      "Polycystic liver disease 3 with or without kidney cysts"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01625",
    "question": "What is associated with Increased radioactive iodine uptake?",
    "seeds": [
      "Increased radioactive iodine uptake"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01626",
    "question": "What is associated with Moyamoya phenomenon?",
    "seeds": [
      "Moyamoya phenomenon"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01627",
    "question": "What is associated with Combined cystic and ground-glass pattern on pulmonary HRCT?",
    "seeds": [
      "Combined cystic and ground-glass pattern on pulmonary HRCT"
    ],
    "gold_answer": "Abnormal pulmonary thoracic imaging finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01628",
    "question": "What is associated with Abnormal 2nd metacarpal morphology?",
    "seeds": [
      "Abnormal 2nd metacarpal morphology"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01629",
    "question": "What phenotype is associated with Retinal dystrophy and microvillus inclusion disease?",
    "seeds": [
      "Retinal dystrophy and microvillus inclusion disease"
    ],
    "gold_answer": "Recurrent lower respiratory tract infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01630",
    "question": "What is associated with Decreased circulating beta-carotene concentration?",
    "seeds": [
      "Decreased circulating beta-carotene concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01631",
    "question": "What is associated with Fluctuations in consciousness?",
    "seeds": [
      "Fluctuations in consciousness"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01632",
    "question": "What phenotype is associated with 46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs?",
    "seeds": [
      "46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the diaphragm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01633",
    "question": "What phenotype is associated with Paroxysmal exertion-induced dyskinesia?",
    "seeds": [
      "Paroxysmal exertion-induced dyskinesia"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01634",
    "question": "What is associated with Pyruvate dehydrogenase deficiency?",
    "seeds": [
      "Pyruvate dehydrogenase deficiency"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01635",
    "question": "What is associated with Radial head fracture?",
    "seeds": [
      "Radial head fracture"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01636",
    "question": "What is associated with Eyelid pain?",
    "seeds": [
      "Eyelid pain"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01637",
    "question": "What phenotype is associated with SCHIZENCEPHALY?",
    "seeds": [
      "SCHIZENCEPHALY"
    ],
    "gold_answer": "Agenesis of corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01638",
    "question": "What is associated with Posterior cerebral artery stenosis?",
    "seeds": [
      "Posterior cerebral artery stenosis"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01639",
    "question": "What is associated with Leukoencephalopathy without lacunae, adult-onset?",
    "seeds": [
      "Leukoencephalopathy without lacunae, adult-onset"
    ],
    "gold_answer": "Generalized non-motor (absence) seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01640",
    "question": "What is associated with Increased CSF histidine concentration?",
    "seeds": [
      "Increased CSF histidine concentration"
    ],
    "gold_answer": "Abnormal CSF histidine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01641",
    "question": "What is associated with Muscular dystrophy, limb-girdle, autosomal recessive 29?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, autosomal recessive 29"
    ],
    "gold_answer": "Abnormality of the musculature of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01642",
    "question": "What is associated with Elevated plasma pyrophosphate?",
    "seeds": [
      "Elevated plasma pyrophosphate"
    ],
    "gold_answer": "Abnormal blood ion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01643",
    "question": "What is associated with Occupational disability?",
    "seeds": [
      "Occupational disability"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01644",
    "question": "What is associated with Mitral valve prolapse 1?",
    "seeds": [
      "Mitral valve prolapse 1"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01645",
    "question": "What is associated with NUT midline carcinoma?",
    "seeds": [
      "NUT midline carcinoma"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01646",
    "question": "What is associated with Congenitally uncorrected transposition of the great arteries with cardiac malformation?",
    "seeds": [
      "Congenitally uncorrected transposition of the great arteries with cardiac malformation"
    ],
    "gold_answer": "CFC1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "candidate_gene_tested_in"
    }
  },
  {
    "query_id": "orph_train_01647",
    "question": "What is associated with Thyrotoxic periodic paralysis, susceptibility to, 1?",
    "seeds": [
      "Thyrotoxic periodic paralysis, susceptibility to, 1"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01648",
    "question": "What is associated with Hypocalcemia, autosomal dominant 2?",
    "seeds": [
      "Hypocalcemia, autosomal dominant 2"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01649",
    "question": "What is associated with Immunodeficiency 60?",
    "seeds": [
      "Immunodeficiency 60"
    ],
    "gold_answer": "Abnormal basophil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01650",
    "question": "What phenotype is associated with Chromosome 2p12-p11.2 deletion syndrome?",
    "seeds": [
      "Chromosome 2p12-p11.2 deletion syndrome"
    ],
    "gold_answer": "Blepharophimosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01651",
    "question": "What phenotype is associated with Self-limited epilepsy with centrotemporal spikes?",
    "seeds": [
      "Self-limited epilepsy with centrotemporal spikes"
    ],
    "gold_answer": "Attention deficit hyperactivity disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01652",
    "question": "What is associated with Mental and growth retardation with amblyopia?",
    "seeds": [
      "Mental and growth retardation with amblyopia"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01653",
    "question": "What is associated with Prolactin deficiency, isolated?",
    "seeds": [
      "Prolactin deficiency, isolated"
    ],
    "gold_answer": "Abnormal prolactin level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01654",
    "question": "What is associated with Hypointensity of cerebral white matter on MRI?",
    "seeds": [
      "Hypointensity of cerebral white matter on MRI"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01655",
    "question": "What is associated with Elevated urinary 3-hydroxybutyric acid?",
    "seeds": [
      "Elevated urinary 3-hydroxybutyric acid"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01656",
    "question": "What is associated with Familial reactive perforating collagenosis?",
    "seeds": [
      "Familial reactive perforating collagenosis"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01657",
    "question": "What is associated with Isolated generalized anhidrosis with normal sweat glands?",
    "seeds": [
      "Isolated generalized anhidrosis with normal sweat glands"
    ],
    "gold_answer": "ITPR2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_01658",
    "question": "What is associated with Occipital encephalocele?",
    "seeds": [
      "Occipital encephalocele"
    ],
    "gold_answer": "DACT1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01659",
    "question": "What is associated with Persistence of hemoglobin F?",
    "seeds": [
      "Persistence of hemoglobin F"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01660",
    "question": "What is associated with Extremities cold to touch?",
    "seeds": [
      "Extremities cold to touch"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01661",
    "question": "What is associated with Abnormal deltoid tuberosity morphology?",
    "seeds": [
      "Abnormal deltoid tuberosity morphology"
    ],
    "gold_answer": "Abnormal humeral diaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01662",
    "question": "What is associated with Underdeveloped inferior crus of antihelix?",
    "seeds": [
      "Underdeveloped inferior crus of antihelix"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01663",
    "question": "What phenotype is associated with Atypical pantothenate kinase-associated neurodegeneration?",
    "seeds": [
      "Atypical pantothenate kinase-associated neurodegeneration"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01664",
    "question": "What is associated with Eating-induced seizure?",
    "seeds": [
      "Eating-induced seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01665",
    "question": "What is associated with Osteosclerosis-developmental delay-craniosynostosis syndrome?",
    "seeds": [
      "Osteosclerosis-developmental delay-craniosynostosis syndrome"
    ],
    "gold_answer": "Weakness of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01666",
    "question": "What is associated with Abnormal choroid morphology?",
    "seeds": [
      "Abnormal choroid morphology"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01667",
    "question": "What is associated with Elevated circulating long chain fatty acid concentration?",
    "seeds": [
      "Elevated circulating long chain fatty acid concentration"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01668",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 9?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 9"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01669",
    "question": "What is associated with Cementum overgrowth?",
    "seeds": [
      "Cementum overgrowth"
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01670",
    "question": "What is associated with Abnormal response to insulin tolerance test?",
    "seeds": [
      "Abnormal response to insulin tolerance test"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01671",
    "question": "What is associated with Joint extensor surface localization?",
    "seeds": [
      "Joint extensor surface localization"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01672",
    "question": "What is associated with Hyperbilirubinemia, familial transient neonatal?",
    "seeds": [
      "Hyperbilirubinemia, familial transient neonatal"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01673",
    "question": "What is associated with Corneal dystrophy, gelatinous drop-like?",
    "seeds": [
      "Corneal dystrophy, gelatinous drop-like"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01674",
    "question": "What is associated with Spinal cord dorsal column hypomyelination?",
    "seeds": [
      "Spinal cord dorsal column hypomyelination"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01675",
    "question": "What is associated with Intratubular vancomycin casts?",
    "seeds": [
      "Intratubular vancomycin casts"
    ],
    "gold_answer": "Renal intratubular casts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01676",
    "question": "What phenotype is associated with Spinocerebellar ataxia 29, congenital nonprogressive?",
    "seeds": [
      "Spinocerebellar ataxia 29, congenital nonprogressive"
    ],
    "gold_answer": "Horizontal nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01677",
    "question": "What is associated with Breast aplasia?",
    "seeds": [
      "Breast aplasia"
    ],
    "gold_answer": "Abnormality of the breast",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01678",
    "question": "What is associated with Myxomatous mitral valve degeneration?",
    "seeds": [
      "Myxomatous mitral valve degeneration"
    ],
    "gold_answer": "Abnormal mitral valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01679",
    "question": "What is associated with Flatulence?",
    "seeds": [
      "Flatulence"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01680",
    "question": "What is associated with Inappropriate sinus tachycardia?",
    "seeds": [
      "Inappropriate sinus tachycardia"
    ],
    "gold_answer": "Sinus tachycardia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01681",
    "question": "What is associated with Nonprogressive encephalopathy?",
    "seeds": [
      "Nonprogressive encephalopathy"
    ],
    "gold_answer": "Encephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01682",
    "question": "What is associated with Diminished prolactin response to thyrotrophin-releasing hormone stimulation?",
    "seeds": [
      "Diminished prolactin response to thyrotrophin-releasing hormone stimulation"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01683",
    "question": "What is associated with Increased level of galactonate in red blood cells?",
    "seeds": [
      "Increased level of galactonate in red blood cells"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01684",
    "question": "What is associated with Partial absence of cerebellar vermis?",
    "seeds": [
      "Partial absence of cerebellar vermis"
    ],
    "gold_answer": "Abnormal cerebellar vermis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01685",
    "question": "What is associated with 1-2 finger cutaneous syndactyly?",
    "seeds": [
      "1-2 finger cutaneous syndactyly"
    ],
    "gold_answer": "Syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01686",
    "question": "What is associated with EEG with frontal focal spikes?",
    "seeds": [
      "EEG with frontal focal spikes"
    ],
    "gold_answer": "EEG with focal epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01687",
    "question": "What is associated with Arthrogryposis and ectodermal dysplasia?",
    "seeds": [
      "Arthrogryposis and ectodermal dysplasia"
    ],
    "gold_answer": "Abnormal number of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01688",
    "question": "What is associated with Absent dermal elastic fibers?",
    "seeds": [
      "Absent dermal elastic fibers"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01689",
    "question": "What is associated with Adrenocortical hypoplasia?",
    "seeds": [
      "Adrenocortical hypoplasia"
    ],
    "gold_answer": "Abnormal endocrine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01690",
    "question": "What is associated with Sphincter of Oddi dyskinesia?",
    "seeds": [
      "Sphincter of Oddi dyskinesia"
    ],
    "gold_answer": "Biliary dyskinesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01691",
    "question": "What is associated with Enlarged epiphyses of the 3rd finger?",
    "seeds": [
      "Enlarged epiphyses of the 3rd finger"
    ],
    "gold_answer": "Enlarged epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01692",
    "question": "What is associated with Tinea imbricata, susceptibility to?",
    "seeds": [
      "Tinea imbricata, susceptibility to"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01693",
    "question": "What is associated with Gastric arteriovenous malformation?",
    "seeds": [
      "Gastric arteriovenous malformation"
    ],
    "gold_answer": "Abnormal gastrointestinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01694",
    "question": "What is associated with Tropical pancreatitis?",
    "seeds": [
      "Tropical pancreatitis"
    ],
    "gold_answer": "Cholestasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01695",
    "question": "What is associated with Intermittent thrombocytopenia?",
    "seeds": [
      "Intermittent thrombocytopenia"
    ],
    "gold_answer": "Thrombocytopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01696",
    "question": "What is associated with Pneumothorax?",
    "seeds": [
      "Pneumothorax"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01697",
    "question": "What is associated with Microcephaly 29, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 29, primary, autosomal recessive"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01698",
    "question": "What is associated with Tooth agenesis, selective, 3?",
    "seeds": [
      "Tooth agenesis, selective, 3"
    ],
    "gold_answer": "Abnormal oral physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01699",
    "question": "What is associated with Hypercoagulability?",
    "seeds": [
      "Hypercoagulability"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01700",
    "question": "What is associated with Decreased circulating pancreatic isoamylase activity?",
    "seeds": [
      "Decreased circulating pancreatic isoamylase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01701",
    "question": "What is associated with Dental crowding?",
    "seeds": [
      "Dental crowding"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01702",
    "question": "What is associated with Distal ulnar hypoplasia?",
    "seeds": [
      "Distal ulnar hypoplasia"
    ],
    "gold_answer": "Hypoplasia of the ulna",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01703",
    "question": "What is associated with Vaginal lymphocele?",
    "seeds": [
      "Vaginal lymphocele"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01704",
    "question": "What is associated with Sputum infectious agent?",
    "seeds": [
      "Sputum infectious agent"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01705",
    "question": "What is associated with Platyspondyly?",
    "seeds": [
      "Platyspondyly"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01706",
    "question": "What is associated with Mesangial matrix expansion?",
    "seeds": [
      "Mesangial matrix expansion"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01707",
    "question": "What is associated with Retinal vasculitis?",
    "seeds": [
      "Retinal vasculitis"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01708",
    "question": "What is associated with Sclerotic humeral metaphysis with longitudinal striations?",
    "seeds": [
      "Sclerotic humeral metaphysis with longitudinal striations"
    ],
    "gold_answer": "Sclerotic humeral metaphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01709",
    "question": "What phenotype is associated with Orotic aciduria?",
    "seeds": [
      "Orotic aciduria"
    ],
    "gold_answer": "Pyrimidine-responsive megaloblastic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01710",
    "question": "What is associated with Decreased blood drug concentration?",
    "seeds": [
      "Decreased blood drug concentration"
    ],
    "gold_answer": "Abnormal drug response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01711",
    "question": "What phenotype is associated with Autosomal dominant spastic paraplegia type 73?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 73"
    ],
    "gold_answer": "Distal lower limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01712",
    "question": "What is associated with Increased urine phenylacetylglutamine level?",
    "seeds": [
      "Increased urine phenylacetylglutamine level"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01713",
    "question": "What is associated with Abnormal urinary bile acid level?",
    "seeds": [
      "Abnormal urinary bile acid level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01714",
    "question": "What is associated with Lacrimoauriculodentodigital syndrome-1?",
    "seeds": [
      "Lacrimoauriculodentodigital syndrome-1"
    ],
    "gold_answer": "Abnormality of the proximal phalanx of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01715",
    "question": "What is associated with Spermatogenic failure 36?",
    "seeds": [
      "Spermatogenic failure 36"
    ],
    "gold_answer": "Decreased fertility in males",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01716",
    "question": "What is associated with Abnormality of facial soft tissue?",
    "seeds": [
      "Abnormality of facial soft tissue"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01717",
    "question": "What is associated with Periorbital edema?",
    "seeds": [
      "Periorbital edema"
    ],
    "gold_answer": "Facial edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01718",
    "question": "What is associated with Renal cortical hypoechogeneity?",
    "seeds": [
      "Renal cortical hypoechogeneity"
    ],
    "gold_answer": "Abnormal renal echogenicity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01719",
    "question": "What is associated with Anti-Glutamate Receptor delta2 antibody positivity?",
    "seeds": [
      "Anti-Glutamate Receptor delta2 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01720",
    "question": "What phenotype is associated with Isotretinoin-like syndrome?",
    "seeds": [
      "Isotretinoin-like syndrome"
    ],
    "gold_answer": "Atresia of the external auditory canal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01721",
    "question": "What is associated with Bowing of the legs?",
    "seeds": [
      "Bowing of the legs"
    ],
    "gold_answer": "Abnormal diaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01722",
    "question": "What is associated with Abnormal HDL cholesterol concentration?",
    "seeds": [
      "Abnormal HDL cholesterol concentration"
    ],
    "gold_answer": "Abnormal circulating cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01723",
    "question": "What is associated with Increased variability in muscle fiber diameter?",
    "seeds": [
      "Increased variability in muscle fiber diameter"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01724",
    "question": "What is associated with Abnormal cerebral cortex morphology?",
    "seeds": [
      "Abnormal cerebral cortex morphology"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01725",
    "question": "What is associated with Low semen volume?",
    "seeds": [
      "Low semen volume"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01726",
    "question": "What is associated with Increased anti-feather IgE antibody level?",
    "seeds": [
      "Increased anti-feather IgE antibody level"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01727",
    "question": "What phenotype is associated with Multiple congenital anomalies-hypotonia-seizures syndrome 3?",
    "seeds": [
      "Multiple congenital anomalies-hypotonia-seizures syndrome 3"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01728",
    "question": "What is associated with Neuroblastoma, susceptibility to, 2?",
    "seeds": [
      "Neuroblastoma, susceptibility to, 2"
    ],
    "gold_answer": "PHOX2B",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_01729",
    "question": "What is associated with Long thorax?",
    "seeds": [
      "Long thorax"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01730",
    "question": "What phenotype is associated with Multicentric carpotarsal osteolysis syndrome?",
    "seeds": [
      "Multicentric carpotarsal osteolysis syndrome"
    ],
    "gold_answer": "Renal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01731",
    "question": "What is associated with Long segment coarctation of the aorta?",
    "seeds": [
      "Long segment coarctation of the aorta"
    ],
    "gold_answer": "Coarctation of aorta",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01732",
    "question": "What is associated with Varus instability of the elbow?",
    "seeds": [
      "Varus instability of the elbow"
    ],
    "gold_answer": "Elbow instability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01733",
    "question": "What is associated with Absent dorsal skin creases over affected joints?",
    "seeds": [
      "Absent dorsal skin creases over affected joints"
    ],
    "gold_answer": "Abnormal finger flexion crease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01734",
    "question": "What is associated with Pseudoepiphysis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Pseudoepiphysis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01735",
    "question": "What phenotype is associated with Progressive supranuclear palsy-predominant parkinsonism syndrome?",
    "seeds": [
      "Progressive supranuclear palsy-predominant parkinsonism syndrome"
    ],
    "gold_answer": "Bradykinesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01736",
    "question": "What is associated with Isolated mesenteric vein thrombosis?",
    "seeds": [
      "Isolated mesenteric vein thrombosis"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01737",
    "question": "What phenotype is associated with Plexiform neurofibroma?",
    "seeds": [
      "Plexiform neurofibroma"
    ],
    "gold_answer": "Spinal meningioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01738",
    "question": "What is associated with Hypospadias 1, X-linked?",
    "seeds": [
      "Hypospadias 1, X-linked"
    ],
    "gold_answer": "Displacement of the urethral meatus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01739",
    "question": "What is associated with High posterior hairline?",
    "seeds": [
      "High posterior hairline"
    ],
    "gold_answer": "Abnormality of the posterior hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01740",
    "question": "What phenotype is associated with Popliteal pterygium syndrome, Bartsocas-Papas type 1?",
    "seeds": [
      "Popliteal pterygium syndrome, Bartsocas-Papas type 1"
    ],
    "gold_answer": "Microphthalmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01741",
    "question": "What is associated with Immune dysregulation with immunodeficiency due to AIOLOS haploinsufficiency?",
    "seeds": [
      "Immune dysregulation with immunodeficiency due to AIOLOS haploinsufficiency"
    ],
    "gold_answer": "IKZF3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01742",
    "question": "What is associated with Oculocerebral hypopigmentation syndrome, Preus type?",
    "seeds": [
      "Oculocerebral hypopigmentation syndrome, Preus type"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01743",
    "question": "What is associated with Intralobular interstitial thickening?",
    "seeds": [
      "Intralobular interstitial thickening"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01744",
    "question": "What is associated with Visual fixation instability?",
    "seeds": [
      "Visual fixation instability"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01745",
    "question": "What is associated with Slowed horizontal saccades?",
    "seeds": [
      "Slowed horizontal saccades"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01746",
    "question": "What is associated with Achlorhydria?",
    "seeds": [
      "Achlorhydria"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01747",
    "question": "What is associated with Impaired vibratory sensation?",
    "seeds": [
      "Impaired vibratory sensation"
    ],
    "gold_answer": "Somatic sensory dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01748",
    "question": "What is associated with Pelizaeus-Merzbacher disease, classic form?",
    "seeds": [
      "Pelizaeus-Merzbacher disease, classic form"
    ],
    "gold_answer": "Abnormal brain-evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01749",
    "question": "What is associated with Persistent hyperplastic primary vitreous, autosomal recessive?",
    "seeds": [
      "Persistent hyperplastic primary vitreous, autosomal recessive"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01750",
    "question": "What is associated with Tubular shadows?",
    "seeds": [
      "Tubular shadows"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01751",
    "question": "What phenotype is associated with Feingold syndrome type 2?",
    "seeds": [
      "Feingold syndrome type 2"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01752",
    "question": "What is associated with Reduced responsiveness to social cues?",
    "seeds": [
      "Reduced responsiveness to social cues"
    ],
    "gold_answer": "Abnormal social behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01753",
    "question": "What is associated with Punding?",
    "seeds": [
      "Punding"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01754",
    "question": "What is associated with Neurodevelopmental disorder with dystonia and seizures?",
    "seeds": [
      "Neurodevelopmental disorder with dystonia and seizures"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01755",
    "question": "What is associated with Recurrent meningococcal disease?",
    "seeds": [
      "Recurrent meningococcal disease"
    ],
    "gold_answer": "Recurrent gram-negative bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01756",
    "question": "What is associated with Cataract 7?",
    "seeds": [
      "Cataract 7"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01757",
    "question": "What is associated with Abnormal hepatobiliary system physiology?",
    "seeds": [
      "Abnormal hepatobiliary system physiology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01758",
    "question": "What phenotype is associated with Levator-Medial rectus synkinesis?",
    "seeds": [
      "Levator-Medial rectus synkinesis"
    ],
    "gold_answer": "Ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01759",
    "question": "What is associated with Elevated circulating 27-hydroxycholesterol concentration?",
    "seeds": [
      "Elevated circulating 27-hydroxycholesterol concentration"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01760",
    "question": "What is associated with Hemifacial microsomia?",
    "seeds": [
      "Hemifacial microsomia"
    ],
    "gold_answer": "Functional abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01761",
    "question": "What is associated with Ichthyosis, congenital, autosomal recessive 13?",
    "seeds": [
      "Ichthyosis, congenital, autosomal recessive 13"
    ],
    "gold_answer": "Abnormal skin morphology of the palm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01762",
    "question": "What is associated with Wolfram syndrome 1?",
    "seeds": [
      "Wolfram syndrome 1"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01763",
    "question": "What phenotype is associated with Methemoglobinemia and ambiguous genitalia?",
    "seeds": [
      "Methemoglobinemia and ambiguous genitalia"
    ],
    "gold_answer": "Elevated circulating luteinizing hormone level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01764",
    "question": "What is associated with Bifid proximal phalanx of the thumb?",
    "seeds": [
      "Bifid proximal phalanx of the thumb"
    ],
    "gold_answer": "Duplication of the proximal phalanx of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01765",
    "question": "What phenotype is associated with IMINOGLYCINURIA?",
    "seeds": [
      "IMINOGLYCINURIA"
    ],
    "gold_answer": "Hydroxyprolinuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01766",
    "question": "What is associated with Increased circulating apolipoprotein circulation?",
    "seeds": [
      "Increased circulating apolipoprotein circulation"
    ],
    "gold_answer": "Abnormal circulating apolipoprotein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01767",
    "question": "What is associated with Secretory diarrhea?",
    "seeds": [
      "Secretory diarrhea"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01768",
    "question": "What is associated with Pancreatic cancer, susceptibility to, 5?",
    "seeds": [
      "Pancreatic cancer, susceptibility to, 5"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01769",
    "question": "What is associated with Rectoureteral fistula?",
    "seeds": [
      "Rectoureteral fistula"
    ],
    "gold_answer": "Rectal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01770",
    "question": "What is associated with Conjunctival follicles?",
    "seeds": [
      "Conjunctival follicles"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01771",
    "question": "What is associated with Tibiotalar synostosis?",
    "seeds": [
      "Tibiotalar synostosis"
    ],
    "gold_answer": "Synostosis involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01772",
    "question": "What phenotype is associated with Trichothiodystrophy 7, nonphotosensitive?",
    "seeds": [
      "Trichothiodystrophy 7, nonphotosensitive"
    ],
    "gold_answer": "Hypohidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01773",
    "question": "What is associated with Rhizomelic syndrome?",
    "seeds": [
      "Rhizomelic syndrome"
    ],
    "gold_answer": "Lower extremity joint dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01774",
    "question": "What is associated with Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7?",
    "seeds": [
      "Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01775",
    "question": "What is associated with Retarded ejaculation?",
    "seeds": [
      "Retarded ejaculation"
    ],
    "gold_answer": "Abnormal ejaculation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01776",
    "question": "What is associated with Slender ulna?",
    "seeds": [
      "Slender ulna"
    ],
    "gold_answer": "Slender forearm bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01777",
    "question": "What is associated with Pituitary microadenoma?",
    "seeds": [
      "Pituitary microadenoma"
    ],
    "gold_answer": "Abnormality of the anterior pituitary",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01778",
    "question": "What is associated with Restlessness?",
    "seeds": [
      "Restlessness"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01779",
    "question": "What phenotype is associated with NESCAV syndrome?",
    "seeds": [
      "NESCAV syndrome"
    ],
    "gold_answer": "Oculomotor apraxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01780",
    "question": "What is associated with Dentin dysplasia type II?",
    "seeds": [
      "Dentin dysplasia type II"
    ],
    "gold_answer": "DSPP",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01781",
    "question": "What phenotype is associated with ATTRV122I amyloidosis?",
    "seeds": [
      "ATTRV122I amyloidosis"
    ],
    "gold_answer": "Polyneuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01782",
    "question": "What is associated with Abnormality of circulating catecholamine level?",
    "seeds": [
      "Abnormality of circulating catecholamine level"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01783",
    "question": "What phenotype is associated with Vesicoureteral reflux 1?",
    "seeds": [
      "Vesicoureteral reflux 1"
    ],
    "gold_answer": "Vesicoureteral reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01784",
    "question": "What is associated with History of recent contralateral injury?",
    "seeds": [
      "History of recent contralateral injury"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01785",
    "question": "What is associated with T-wave alternans?",
    "seeds": [
      "T-wave alternans"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01786",
    "question": "What is associated with Distal arthrogryposis?",
    "seeds": [
      "Distal arthrogryposis"
    ],
    "gold_answer": "Congenital contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01787",
    "question": "What is associated with Neuronopathy, distal hereditary motor, type VIIA?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, type VIIA"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01788",
    "question": "What phenotype is associated with Infantile LAD-like disease due to RAC2 deficiency?",
    "seeds": [
      "Infantile LAD-like disease due to RAC2 deficiency"
    ],
    "gold_answer": "Immunodeficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01789",
    "question": "What is associated with Breast abscess?",
    "seeds": [
      "Breast abscess"
    ],
    "gold_answer": "Abnormal immune system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01790",
    "question": "What is associated with Pseudoepiphyses of second metacarpal?",
    "seeds": [
      "Pseudoepiphyses of second metacarpal"
    ],
    "gold_answer": "Metacarpal pseudoepiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01791",
    "question": "What phenotype is associated with Nemaline myopathy 5C, autosomal dominant?",
    "seeds": [
      "Nemaline myopathy 5C, autosomal dominant"
    ],
    "gold_answer": "Pes cavus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01792",
    "question": "What is associated with Retinitis pigmentosa 72?",
    "seeds": [
      "Retinitis pigmentosa 72"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01793",
    "question": "What phenotype is associated with Amelogenesis imperfecta, type IC?",
    "seeds": [
      "Amelogenesis imperfecta, type IC"
    ],
    "gold_answer": "Widely spaced teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01794",
    "question": "What phenotype is associated with Hyperinsulinemic hypoglycemia, familial, 7?",
    "seeds": [
      "Hyperinsulinemic hypoglycemia, familial, 7"
    ],
    "gold_answer": "Hypoglycemic seizures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01795",
    "question": "What is associated with Anti-cryptococcal antibody positivity?",
    "seeds": [
      "Anti-cryptococcal antibody positivity"
    ],
    "gold_answer": "Bloodstream antifungal antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01796",
    "question": "What is associated with Snijders Blok-Fisher syndrome?",
    "seeds": [
      "Snijders Blok-Fisher syndrome"
    ],
    "gold_answer": "Abnormality of facial soft tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01797",
    "question": "What is associated with Stippling of the epiphysis of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Stippling of the epiphysis of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Epiphyseal stippling of finger phalanges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01798",
    "question": "What is associated with Multiple long-bone exostoses?",
    "seeds": [
      "Multiple long-bone exostoses"
    ],
    "gold_answer": "Multiple exostoses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01799",
    "question": "What is associated with Familial progressive hyper- and hypopigmentation?",
    "seeds": [
      "Familial progressive hyper- and hypopigmentation"
    ],
    "gold_answer": "KITLG",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01800",
    "question": "What is associated with Increased PIVKA-II?",
    "seeds": [
      "Increased PIVKA-II"
    ],
    "gold_answer": "Abnormality of vitamin metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01801",
    "question": "What is associated with Furcate cord insertion?",
    "seeds": [
      "Furcate cord insertion"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01802",
    "question": "What is associated with Naevus flammeus of the eyelid?",
    "seeds": [
      "Naevus flammeus of the eyelid"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01803",
    "question": "What is associated with Vagal paraganglioma?",
    "seeds": [
      "Vagal paraganglioma"
    ],
    "gold_answer": "Neuroendocrine neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01804",
    "question": "What is associated with Keratoglobus?",
    "seeds": [
      "Keratoglobus"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01805",
    "question": "What is associated with Persistent idiopathic facial pain?",
    "seeds": [
      "Persistent idiopathic facial pain"
    ],
    "gold_answer": "Abnormal exteroceptive sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01806",
    "question": "What is associated with INCISORS, LONG UPPER CENTRAL?",
    "seeds": [
      "INCISORS, LONG UPPER CENTRAL"
    ],
    "gold_answer": "Abnormal incisor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01807",
    "question": "What is associated with Elevated circulating gamma-aminobutyric acid concentration?",
    "seeds": [
      "Elevated circulating gamma-aminobutyric acid concentration"
    ],
    "gold_answer": "Abnormal circulating GABA concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01808",
    "question": "What is associated with High urinary gonadotropin level?",
    "seeds": [
      "High urinary gonadotropin level"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01809",
    "question": "What is associated with Partial duplication of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Partial duplication of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal morphology of the proximal phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01810",
    "question": "What is associated with Decreased fecal pH?",
    "seeds": [
      "Decreased fecal pH"
    ],
    "gold_answer": "Abnormal stool composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01811",
    "question": "What is associated with Abnormal circulating prostaglandin circulation?",
    "seeds": [
      "Abnormal circulating prostaglandin circulation"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01812",
    "question": "What is associated with Fetal fifth finger clinodactyly?",
    "seeds": [
      "Fetal fifth finger clinodactyly"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01813",
    "question": "What is associated with Positive tissue encapsulated budding yeast test?",
    "seeds": [
      "Positive tissue encapsulated budding yeast test"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01814",
    "question": "What is associated with Abnormality of the epiphysis of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Abnormality of the epiphysis of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal 3rd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01815",
    "question": "What is associated with Absent epiphysis of the 1st metatarsal?",
    "seeds": [
      "Absent epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Abnormality of the epiphyses of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01816",
    "question": "What is associated with Abnormality of the upper urinary tract?",
    "seeds": [
      "Abnormality of the upper urinary tract"
    ],
    "gold_answer": "Abnormality of the urinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01817",
    "question": "What is associated with Enlargement of the ankles?",
    "seeds": [
      "Enlargement of the ankles"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01818",
    "question": "What is associated with Coarse humeral trabeculae?",
    "seeds": [
      "Coarse humeral trabeculae"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01819",
    "question": "What is associated with Actinic keratosis?",
    "seeds": [
      "Actinic keratosis"
    ],
    "gold_answer": "Neoplasm of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01820",
    "question": "What is associated with Tenosynovitis?",
    "seeds": [
      "Tenosynovitis"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01821",
    "question": "What is associated with Mesangial Immune complex deposition?",
    "seeds": [
      "Mesangial Immune complex deposition"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01822",
    "question": "What is associated with Recurrent streptococcus pneumoniae infections?",
    "seeds": [
      "Recurrent streptococcus pneumoniae infections"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01823",
    "question": "What phenotype is associated with 46,xx sex reversal 3?",
    "seeds": [
      "46,xx sex reversal 3"
    ],
    "gold_answer": "Sex reversal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01824",
    "question": "What is associated with Partial duplication of the proximal phalanx of the hallux?",
    "seeds": [
      "Partial duplication of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Duplication of phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01825",
    "question": "What is associated with Chemodectoma?",
    "seeds": [
      "Chemodectoma"
    ],
    "gold_answer": "Neuroendocrine neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01826",
    "question": "What is associated with Lunotriquetral ligament tear?",
    "seeds": [
      "Lunotriquetral ligament tear"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01827",
    "question": "What is associated with Coloboma of optic nerveoptic nerve head pits, bilateral congenital, included?",
    "seeds": [
      "Coloboma of optic nerveoptic nerve head pits, bilateral congenital, included"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01828",
    "question": "What is associated with Abnormal perceptual state?",
    "seeds": [
      "Abnormal perceptual state"
    ],
    "gold_answer": "Abnormal interpretation of external stimuli",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01829",
    "question": "What is associated with Anal fissure?",
    "seeds": [
      "Anal fissure"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01830",
    "question": "What is associated with Toe symphalangism?",
    "seeds": [
      "Toe symphalangism"
    ],
    "gold_answer": "Toe phalanx synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01831",
    "question": "What is associated with Elevated circulating phosphoethanolamine concentration?",
    "seeds": [
      "Elevated circulating phosphoethanolamine concentration"
    ],
    "gold_answer": "Abnormal circulating organic amino compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01832",
    "question": "What is associated with Chronic noninfectious lymphadenopathy?",
    "seeds": [
      "Chronic noninfectious lymphadenopathy"
    ],
    "gold_answer": "Lymphadenopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01833",
    "question": "What is associated with Retinitis pigmentosa 95?",
    "seeds": [
      "Retinitis pigmentosa 95"
    ],
    "gold_answer": "Abnormal retinal pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01834",
    "question": "What is associated with Anti-steroid 17alpha-hydroxylase antibody positivity?",
    "seeds": [
      "Anti-steroid 17alpha-hydroxylase antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01835",
    "question": "What is associated with Ohdo syndrome?",
    "seeds": [
      "Ohdo syndrome"
    ],
    "gold_answer": "Abnormal nasal bridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01836",
    "question": "What is associated with Hypogonadotropic hypogonadism 3 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 3 with or without anosmia"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01837",
    "question": "What is associated with Alopecia-intellectual disability syndrome 4?",
    "seeds": [
      "Alopecia-intellectual disability syndrome 4"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01838",
    "question": "What is associated with Hypoplasia of the midbrain?",
    "seeds": [
      "Hypoplasia of the midbrain"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01839",
    "question": "What is associated with Anhedonia?",
    "seeds": [
      "Anhedonia"
    ],
    "gold_answer": "Dysregulated negative emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01840",
    "question": "What is associated with Telangiectasia macularis eruptiva perstans?",
    "seeds": [
      "Telangiectasia macularis eruptiva perstans"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01841",
    "question": "What is associated with Abnormal urine sebacic acid concentration?",
    "seeds": [
      "Abnormal urine sebacic acid concentration"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01842",
    "question": "What is associated with Aplasia/hypoplasia involving bones of the hand?",
    "seeds": [
      "Aplasia/hypoplasia involving bones of the hand"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01843",
    "question": "What is associated with Reduced fetal femur/foot length ratio?",
    "seeds": [
      "Reduced fetal femur/foot length ratio"
    ],
    "gold_answer": "Abnormal fetal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01844",
    "question": "What is associated with Hepatomegaly?",
    "seeds": [
      "Hepatomegaly"
    ],
    "gold_answer": "Visceromegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01845",
    "question": "What phenotype is associated with Cutaneous mastocytosis-deafness-microtia syndrome?",
    "seeds": [
      "Cutaneous mastocytosis-deafness-microtia syndrome"
    ],
    "gold_answer": "Areflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01846",
    "question": "What is associated with MHC class I deficiency 2?",
    "seeds": [
      "MHC class I deficiency 2"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01847",
    "question": "What is associated with Hemorrhoids?",
    "seeds": [
      "Hemorrhoids"
    ],
    "gold_answer": "Abnormal large intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01848",
    "question": "What is associated with Hypnopompic sleep paralysis?",
    "seeds": [
      "Hypnopompic sleep paralysis"
    ],
    "gold_answer": "Parasomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01849",
    "question": "What is associated with Decreased monosialylated core 1 O-glycan level?",
    "seeds": [
      "Decreased monosialylated core 1 O-glycan level"
    ],
    "gold_answer": "Abnormal protein O-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01850",
    "question": "What is associated with Xanthomatosis?",
    "seeds": [
      "Xanthomatosis"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01851",
    "question": "What is associated with Porphyria, acute hepatic?",
    "seeds": [
      "Porphyria, acute hepatic"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01852",
    "question": "What is associated with Hyperextensible skin of chest?",
    "seeds": [
      "Hyperextensible skin of chest"
    ],
    "gold_answer": "Abnormally lax or hyperextensible skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01853",
    "question": "What is associated with Maternal fever in pregnancy?",
    "seeds": [
      "Maternal fever in pregnancy"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01854",
    "question": "What phenotype is associated with Spastic paraplegia 82, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 82, autosomal recessive"
    ],
    "gold_answer": "Babinski sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01855",
    "question": "What is associated with Slowed horizontal saccades?",
    "seeds": [
      "Slowed horizontal saccades"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01856",
    "question": "What is associated with Megakaryocytopenia?",
    "seeds": [
      "Megakaryocytopenia"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01857",
    "question": "What is associated with PLIN4-related distal myopathy?",
    "seeds": [
      "PLIN4-related distal myopathy"
    ],
    "gold_answer": "PLIN4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01858",
    "question": "What is associated with Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 1?",
    "seeds": [
      "Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 1"
    ],
    "gold_answer": "Viral encephalitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01859",
    "question": "What is associated with Abnormal urinary 3-methylhistidine level?",
    "seeds": [
      "Abnormal urinary 3-methylhistidine level"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01860",
    "question": "What is associated with Elevated urinary uroporphyrin level?",
    "seeds": [
      "Elevated urinary uroporphyrin level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01861",
    "question": "What is associated with Abnormal hair pattern?",
    "seeds": [
      "Abnormal hair pattern"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01862",
    "question": "What is associated with Curved distal phalanx of the 5th finger?",
    "seeds": [
      "Curved distal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01863",
    "question": "What is associated with Dowling-Degos disease 2?",
    "seeds": [
      "Dowling-Degos disease 2"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01864",
    "question": "What is associated with Fetal akinesia, respiratory insufficiency, microcephaly, polymicrogyria, and dysmorphic facies?",
    "seeds": [
      "Fetal akinesia, respiratory insufficiency, microcephaly, polymicrogyria, and dysmorphic facies"
    ],
    "gold_answer": "Abnormal cerebral cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01865",
    "question": "What is associated with Elevated thallium concentration?",
    "seeds": [
      "Elevated thallium concentration"
    ],
    "gold_answer": "Presence of xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01866",
    "question": "What is associated with Symphalangism with multiple anomalies of hands and feet?",
    "seeds": [
      "Symphalangism with multiple anomalies of hands and feet"
    ],
    "gold_answer": "Absent toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01867",
    "question": "What is associated with Dorsal subluxation of ulna?",
    "seeds": [
      "Dorsal subluxation of ulna"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01868",
    "question": "What is associated with Decreased maximal oxygen uptake?",
    "seeds": [
      "Decreased maximal oxygen uptake"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01869",
    "question": "What is associated with Multicentric femoral head ossification?",
    "seeds": [
      "Multicentric femoral head ossification"
    ],
    "gold_answer": "Abnormal ossification involving the femoral head and neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01870",
    "question": "What is associated with Sleep onset rapid eye movement period?",
    "seeds": [
      "Sleep onset rapid eye movement period"
    ],
    "gold_answer": "Parasomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01871",
    "question": "What phenotype is associated with X-linked intellectual disability, Van Esch type?",
    "seeds": [
      "X-linked intellectual disability, Van Esch type"
    ],
    "gold_answer": "Atresia of the external auditory canal",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01872",
    "question": "What is associated with Lacrimoauriculodentodigital syndrome?",
    "seeds": [
      "Lacrimoauriculodentodigital syndrome"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01873",
    "question": "What is associated with Central diabetes insipidus?",
    "seeds": [
      "Central diabetes insipidus"
    ],
    "gold_answer": "Diabetes insipidus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01874",
    "question": "What phenotype is associated with Symptomatic form of HFE-related hemochromatosis?",
    "seeds": [
      "Symptomatic form of HFE-related hemochromatosis"
    ],
    "gold_answer": "Amenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01875",
    "question": "What is associated with Hydrocephalus-obesity-hypogonadism syndrome?",
    "seeds": [
      "Hydrocephalus-obesity-hypogonadism syndrome"
    ],
    "gold_answer": "Abnormal elbow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01876",
    "question": "What is associated with Female fetal virilization?",
    "seeds": [
      "Female fetal virilization"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01877",
    "question": "What phenotype is associated with Hypertelorism-microtia-facial clefting syndrome?",
    "seeds": [
      "Hypertelorism-microtia-facial clefting syndrome"
    ],
    "gold_answer": "Atresia of the external auditory canal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01878",
    "question": "What is associated with Limited hip extension?",
    "seeds": [
      "Limited hip extension"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01879",
    "question": "What is associated with Absent circulating immunoglobulin kappa chain?",
    "seeds": [
      "Absent circulating immunoglobulin kappa chain"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01880",
    "question": "What is associated with Abnormal bleeding?",
    "seeds": [
      "Abnormal bleeding"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01881",
    "question": "What phenotype is associated with Hemoglobin-Delta locus?",
    "seeds": [
      "Hemoglobin-Delta locus"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01882",
    "question": "What phenotype is associated with Mesomelic dysplasia, Nievergelt type?",
    "seeds": [
      "Mesomelic dysplasia, Nievergelt type"
    ],
    "gold_answer": "Finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01883",
    "question": "What is associated with Deafness, autosomal recessive 108?",
    "seeds": [
      "Deafness, autosomal recessive 108"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01884",
    "question": "What is associated with Increased resting energy expenditure?",
    "seeds": [
      "Increased resting energy expenditure"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01885",
    "question": "What is associated with Punctate keratitis?",
    "seeds": [
      "Punctate keratitis"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01886",
    "question": "What is associated with Bacteremia?",
    "seeds": [
      "Bacteremia"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01887",
    "question": "What is associated with Terminal insomnia?",
    "seeds": [
      "Terminal insomnia"
    ],
    "gold_answer": "Insomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01888",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2KK?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2KK"
    ],
    "gold_answer": "Functional motor deficit",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01889",
    "question": "What is associated with Forefoot adduction contracture?",
    "seeds": [
      "Forefoot adduction contracture"
    ],
    "gold_answer": "Ankle contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01890",
    "question": "What is associated with Aplasia of the distal phalanx of the 4th toe?",
    "seeds": [
      "Aplasia of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Aplasia of the phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01891",
    "question": "What is associated with Abnormal kinetic perimetry test?",
    "seeds": [
      "Abnormal kinetic perimetry test"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01892",
    "question": "What is associated with Triggered by dehydration?",
    "seeds": [
      "Triggered by dehydration"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01893",
    "question": "What is associated with Cholestatic liver disease?",
    "seeds": [
      "Cholestatic liver disease"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01894",
    "question": "What phenotype is associated with Pseudohermaphroditism, male, with gynecomastia?",
    "seeds": [
      "Pseudohermaphroditism, male, with gynecomastia"
    ],
    "gold_answer": "Female external genitalia in individual with 46,XY karyotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01895",
    "question": "What is associated with Thin lower lip vermilion?",
    "seeds": [
      "Thin lower lip vermilion"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01896",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 27?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 27"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01897",
    "question": "What is associated with Abnormal vagina morphology?",
    "seeds": [
      "Abnormal vagina morphology"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01898",
    "question": "What is associated with Maladaptive fear-related cognitions?",
    "seeds": [
      "Maladaptive fear-related cognitions"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01899",
    "question": "What is associated with Coproporphyria?",
    "seeds": [
      "Coproporphyria"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01900",
    "question": "What is associated with Isovaleric acid, inability to smell?",
    "seeds": [
      "Isovaleric acid, inability to smell"
    ],
    "gold_answer": "Abnormality of the sense of smell",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01901",
    "question": "What is associated with Decreased pre-bronchodilator forced vital capacity?",
    "seeds": [
      "Decreased pre-bronchodilator forced vital capacity"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01902",
    "question": "What is associated with Diaphragmatic hernia 2?",
    "seeds": [
      "Diaphragmatic hernia 2"
    ],
    "gold_answer": "Abnormal blood oxygen level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01903",
    "question": "What is associated with Cardiomyopathy, dilated, 2L?",
    "seeds": [
      "Cardiomyopathy, dilated, 2L"
    ],
    "gold_answer": "Abnormal cardiac septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01904",
    "question": "What is associated with Pseudohypoaldosteronism, type IIC?",
    "seeds": [
      "Pseudohypoaldosteronism, type IIC"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01905",
    "question": "What is associated with Trichodiscoma?",
    "seeds": [
      "Trichodiscoma"
    ],
    "gold_answer": "Skin appendage neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01906",
    "question": "What is associated with Pentosuria?",
    "seeds": [
      "Pentosuria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01907",
    "question": "What phenotype is associated with Adrenal hypoplasia, congenital?",
    "seeds": [
      "Adrenal hypoplasia, congenital"
    ],
    "gold_answer": "Oligozoospermia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01908",
    "question": "What is associated with Benign neoplasm of the central nervous system?",
    "seeds": [
      "Benign neoplasm of the central nervous system"
    ],
    "gold_answer": "Neoplasm of the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01909",
    "question": "What is associated with Focal impaired awareness autonomic seizure with pupillary dilation/constriction?",
    "seeds": [
      "Focal impaired awareness autonomic seizure with pupillary dilation/constriction"
    ],
    "gold_answer": "Focal autonomic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01910",
    "question": "What is associated with Failure to increase oxygen saturation on hyperoxia test?",
    "seeds": [
      "Failure to increase oxygen saturation on hyperoxia test"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01911",
    "question": "What is associated with Focal aware non-motor seizure?",
    "seeds": [
      "Focal aware non-motor seizure"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01912",
    "question": "What is associated with Reduced factor VII activity?",
    "seeds": [
      "Reduced factor VII activity"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01913",
    "question": "What is associated with Superior shoulder pain?",
    "seeds": [
      "Superior shoulder pain"
    ],
    "gold_answer": "Shoulder pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01914",
    "question": "What is associated with Abnormal lymphocyte physiology?",
    "seeds": [
      "Abnormal lymphocyte physiology"
    ],
    "gold_answer": "Abnormal leukocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01915",
    "question": "What is associated with Posttussive emesis?",
    "seeds": [
      "Posttussive emesis"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01916",
    "question": "What is associated with Intraventricular hemorrhage?",
    "seeds": [
      "Intraventricular hemorrhage"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01917",
    "question": "What phenotype is associated with Fatty liver disease, nonalcoholic, susceptibility to, 2?",
    "seeds": [
      "Fatty liver disease, nonalcoholic, susceptibility to, 2"
    ],
    "gold_answer": "Hepatic steatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01918",
    "question": "What is associated with Transient decreased circulating IgG2?",
    "seeds": [
      "Transient decreased circulating IgG2"
    ],
    "gold_answer": "Decreased circulating IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01919",
    "question": "What is associated with Colorectal cancer, hereditary nonpolyposis, type 2?",
    "seeds": [
      "Colorectal cancer, hereditary nonpolyposis, type 2"
    ],
    "gold_answer": "Neoplasm of the colon",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01920",
    "question": "What phenotype is associated with Muscular dystrophy, limb-girdle, type 2H?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, type 2H"
    ],
    "gold_answer": "Paresthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01921",
    "question": "What phenotype is associated with Right atrial isomerism (Ivemark)?",
    "seeds": [
      "Right atrial isomerism (Ivemark)"
    ],
    "gold_answer": "Pathologic fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01922",
    "question": "What is associated with Positive synovial Tropheryma whipplei bacteria microscopy?",
    "seeds": [
      "Positive synovial Tropheryma whipplei bacteria microscopy"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01923",
    "question": "What is associated with 19p13.13 microdeletion syndrome?",
    "seeds": [
      "19p13.13 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01924",
    "question": "What is associated with Mosaic trisomy 20 syndrome?",
    "seeds": [
      "Mosaic trisomy 20 syndrome"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01925",
    "question": "What is associated with Recurrent bronchopulmonary infections?",
    "seeds": [
      "Recurrent bronchopulmonary infections"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01926",
    "question": "What is associated with Abnormal amplitude of pattern onset/offset visual evoked potentials?",
    "seeds": [
      "Abnormal amplitude of pattern onset/offset visual evoked potentials"
    ],
    "gold_answer": "Abnormality of pattern visual evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01927",
    "question": "What is associated with Inflammatory bowel disease, immunodeficiency, and encephalopathy?",
    "seeds": [
      "Inflammatory bowel disease, immunodeficiency, and encephalopathy"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01928",
    "question": "What phenotype is associated with Intellectual developmental disorder with impaired language and dysmorphic facies?",
    "seeds": [
      "Intellectual developmental disorder with impaired language and dysmorphic facies"
    ],
    "gold_answer": "Motor stereotypy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01929",
    "question": "What is associated with Arachnoiditis?",
    "seeds": [
      "Arachnoiditis"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01930",
    "question": "What is associated with Nipple tenderness?",
    "seeds": [
      "Nipple tenderness"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01931",
    "question": "What is associated with Upper-body predominance?",
    "seeds": [
      "Upper-body predominance"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01932",
    "question": "What is associated with Abnormality of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Abnormality of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01933",
    "question": "What is associated with Aspiration pneumonia?",
    "seeds": [
      "Aspiration pneumonia"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01934",
    "question": "What is associated with Partial absence of specific antibody response to tetanus vaccine?",
    "seeds": [
      "Partial absence of specific antibody response to tetanus vaccine"
    ],
    "gold_answer": "Decreased specific antibody response to vaccination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01935",
    "question": "What is associated with Choreoacanthocytosis?",
    "seeds": [
      "Choreoacanthocytosis"
    ],
    "gold_answer": "Abnormal calf musculature morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01936",
    "question": "What is associated with Epilepsy, familial focal, with variable foci 2?",
    "seeds": [
      "Epilepsy, familial focal, with variable foci 2"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01937",
    "question": "What is associated with Restricted or repetitive behaviors or interests?",
    "seeds": [
      "Restricted or repetitive behaviors or interests"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01938",
    "question": "What is associated with Recurrent pneumonia?",
    "seeds": [
      "Recurrent pneumonia"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01939",
    "question": "What is associated with Epidermodysplasia verruciformis, susceptibility to, 5?",
    "seeds": [
      "Epidermodysplasia verruciformis, susceptibility to, 5"
    ],
    "gold_answer": "Meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01940",
    "question": "What is associated with Xq27.3q28 duplication syndrome?",
    "seeds": [
      "Xq27.3q28 duplication syndrome"
    ],
    "gold_answer": "Obesity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01941",
    "question": "What is associated with Increased circulating IgG subclass?",
    "seeds": [
      "Increased circulating IgG subclass"
    ],
    "gold_answer": "Increased circulating IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01942",
    "question": "What is associated with Reduced muscle telethonin level?",
    "seeds": [
      "Reduced muscle telethonin level"
    ],
    "gold_answer": "Abnormal muscle fiber protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01943",
    "question": "What is associated with Isolated splenogonadal fusion?",
    "seeds": [
      "Isolated splenogonadal fusion"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01944",
    "question": "What is associated with Decreased serum estradiol?",
    "seeds": [
      "Decreased serum estradiol"
    ],
    "gold_answer": "Abnormal circulating sex hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01945",
    "question": "What is associated with Pseudohypoaldosteronism, type I, autosomal dominant?",
    "seeds": [
      "Pseudohypoaldosteronism, type I, autosomal dominant"
    ],
    "gold_answer": "Abnormal blood monovalent inorganic cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01946",
    "question": "What is associated with Proximal tapering of metacarpals?",
    "seeds": [
      "Proximal tapering of metacarpals"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01947",
    "question": "What is associated with Cardiac valve calcification?",
    "seeds": [
      "Cardiac valve calcification"
    ],
    "gold_answer": "Abnormal heart valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01948",
    "question": "What phenotype is associated with Neuropathy, hereditary sensory, type IE?",
    "seeds": [
      "Neuropathy, hereditary sensory, type IE"
    ],
    "gold_answer": "Osteomyelitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01949",
    "question": "What phenotype is associated with Acheiropody?",
    "seeds": [
      "Acheiropody"
    ],
    "gold_answer": "Peromelia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01950",
    "question": "What is associated with Femoral bowing present at birth, straightening with time?",
    "seeds": [
      "Femoral bowing present at birth, straightening with time"
    ],
    "gold_answer": "Abnormality of the calf",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01951",
    "question": "What phenotype is associated with Amish nemaline myopathy?",
    "seeds": [
      "Amish nemaline myopathy"
    ],
    "gold_answer": "Shoulder flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01952",
    "question": "What is associated with Upper limb peromelia?",
    "seeds": [
      "Upper limb peromelia"
    ],
    "gold_answer": "Peromelia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01953",
    "question": "What phenotype is associated with Brown syndrome?",
    "seeds": [
      "Brown syndrome"
    ],
    "gold_answer": "Diplopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01954",
    "question": "What is associated with Orbital rhabdomyosarcoma?",
    "seeds": [
      "Orbital rhabdomyosarcoma"
    ],
    "gold_answer": "Soft tissue sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01955",
    "question": "What is associated with Anti-AK5 antibody positivity?",
    "seeds": [
      "Anti-AK5 antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01956",
    "question": "What is associated with Moderate albuminuria?",
    "seeds": [
      "Moderate albuminuria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01957",
    "question": "What phenotype is associated with Orofacial cleft 15?",
    "seeds": [
      "Orofacial cleft 15"
    ],
    "gold_answer": "Agenesis of lateral incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01958",
    "question": "What is associated with Adrenocortical carcinoma with pure aldosterone hypersecretion?",
    "seeds": [
      "Adrenocortical carcinoma with pure aldosterone hypersecretion"
    ],
    "gold_answer": "Abnormal urine potassium concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01959",
    "question": "What is associated with Anal canal neoplasm?",
    "seeds": [
      "Anal canal neoplasm"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01960",
    "question": "What is associated with X-linked intellectual disability, Snyder type?",
    "seeds": [
      "X-linked intellectual disability, Snyder type"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01961",
    "question": "What is associated with Cerebellar hemorrhage?",
    "seeds": [
      "Cerebellar hemorrhage"
    ],
    "gold_answer": "Intracranial hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01962",
    "question": "What is associated with Nemaline myopathy 7?",
    "seeds": [
      "Nemaline myopathy 7"
    ],
    "gold_answer": "Muscle fiber inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01963",
    "question": "What is associated with Hypnagogic sleep paralysis?",
    "seeds": [
      "Hypnagogic sleep paralysis"
    ],
    "gold_answer": "Abnormal transition from sleep to wakefulness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01964",
    "question": "What is associated with Absent epiphyses of the thumb?",
    "seeds": [
      "Absent epiphyses of the thumb"
    ],
    "gold_answer": "Abnormal hand epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01965",
    "question": "What is associated with Asymmetric blood pressure between arms?",
    "seeds": [
      "Asymmetric blood pressure between arms"
    ],
    "gold_answer": "Asymmetric blood pressure between limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01966",
    "question": "What is associated with Irregular epiphysis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Irregular epiphysis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the middle phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01967",
    "question": "What is associated with Fibrosis, neurodegeneration, and cerebral angiomatosis?",
    "seeds": [
      "Fibrosis, neurodegeneration, and cerebral angiomatosis"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01968",
    "question": "What is associated with Ash-leaf spot?",
    "seeds": [
      "Ash-leaf spot"
    ],
    "gold_answer": "Hypopigmented macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01969",
    "question": "What is associated with Abnormal mixed venous oxygen saturation?",
    "seeds": [
      "Abnormal mixed venous oxygen saturation"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01970",
    "question": "What is associated with Antilactoferrin antibody positivity?",
    "seeds": [
      "Antilactoferrin antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01971",
    "question": "What phenotype is associated with Syndromic X-linked intellectual disability 7?",
    "seeds": [
      "Syndromic X-linked intellectual disability 7"
    ],
    "gold_answer": "Hypoplasia of penis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01972",
    "question": "What is associated with Ipsilateral lack of facial sweating?",
    "seeds": [
      "Ipsilateral lack of facial sweating"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01973",
    "question": "What is associated with Hypoplasia of the prostate?",
    "seeds": [
      "Hypoplasia of the prostate"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01974",
    "question": "What is associated with Mucopolysaccharidosis type 6, rapidly progressing?",
    "seeds": [
      "Mucopolysaccharidosis type 6, rapidly progressing"
    ],
    "gold_answer": "ARSB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_01975",
    "question": "What is associated with Bracket epiphysis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Bracket epiphysis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Bracket epiphyses of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01976",
    "question": "What is associated with Bracket metacarpal epiphyses?",
    "seeds": [
      "Bracket metacarpal epiphyses"
    ],
    "gold_answer": "Abnormal metacarpal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01977",
    "question": "What phenotype is associated with Erythroleukemia, familial, susceptibility to?",
    "seeds": [
      "Erythroleukemia, familial, susceptibility to"
    ],
    "gold_answer": "Leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01978",
    "question": "What is associated with Chronic active Epstein-Barr virus infection?",
    "seeds": [
      "Chronic active Epstein-Barr virus infection"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01979",
    "question": "What is associated with Patent ductus arteriosus after birth at term?",
    "seeds": [
      "Patent ductus arteriosus after birth at term"
    ],
    "gold_answer": "Patent ductus arteriosus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01980",
    "question": "What is associated with Sclerotic radial metaphysis with longitudinal striations?",
    "seeds": [
      "Sclerotic radial metaphysis with longitudinal striations"
    ],
    "gold_answer": "Sclerosis of metaphyses of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01981",
    "question": "What is associated with Enlarged epiphysis of the middle phalanx of the 5th toe?",
    "seeds": [
      "Enlarged epiphysis of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Enlarged epiphyses of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01982",
    "question": "What is associated with Familial developmental dysphasia?",
    "seeds": [
      "Familial developmental dysphasia"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01983",
    "question": "What is associated with Microphthalmia, isolated, with coloboma 10?",
    "seeds": [
      "Microphthalmia, isolated, with coloboma 10"
    ],
    "gold_answer": "Ocular anterior segment dysgenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01984",
    "question": "What is associated with Reduced erythrocyte free porphyrin concentration?",
    "seeds": [
      "Reduced erythrocyte free porphyrin concentration"
    ],
    "gold_answer": "Abnormal circulating porphyrin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01985",
    "question": "What is associated with Occupational exposure history?",
    "seeds": [
      "Occupational exposure history"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01986",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 68?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 68"
    ],
    "gold_answer": "Delayed ability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01987",
    "question": "What is associated with Cutis laxa?",
    "seeds": [
      "Cutis laxa"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01988",
    "question": "What is associated with Global cerebellar dysplasia?",
    "seeds": [
      "Global cerebellar dysplasia"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01989",
    "question": "What is associated with Bracket epiphyses of the proximal phalanges of the hand?",
    "seeds": [
      "Bracket epiphyses of the proximal phalanges of the hand"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01990",
    "question": "What is associated with Malar prominence?",
    "seeds": [
      "Malar prominence"
    ],
    "gold_answer": "Abnormal midface morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01991",
    "question": "What phenotype is associated with Hyperkeratosis lenticularis perstans?",
    "seeds": [
      "Hyperkeratosis lenticularis perstans"
    ],
    "gold_answer": "Squamous cell carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_01992",
    "question": "What is associated with Incomplete ossification of pubis?",
    "seeds": [
      "Incomplete ossification of pubis"
    ],
    "gold_answer": "Abnormal pubic bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01993",
    "question": "What is associated with Increased red cell osmotic resistance?",
    "seeds": [
      "Increased red cell osmotic resistance"
    ],
    "gold_answer": "Abnormal erythrocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01994",
    "question": "What is associated with Reduced circulating interleukin 22 concentration?",
    "seeds": [
      "Reduced circulating interleukin 22 concentration"
    ],
    "gold_answer": "Abnormal circulating interleukin 22 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01995",
    "question": "What is associated with Abnormal factor IX activity?",
    "seeds": [
      "Abnormal factor IX activity"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01996",
    "question": "What is associated with Blepharochalasis and double lip?",
    "seeds": [
      "Blepharochalasis and double lip"
    ],
    "gold_answer": "Abnormal thyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01997",
    "question": "What is associated with Parkinsonism-Dystonia, infantile, 1?",
    "seeds": [
      "Parkinsonism-Dystonia, infantile, 1"
    ],
    "gold_answer": "Abnormal esophagus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01998",
    "question": "What is associated with Fractured epiphysis of third metatarsal bone?",
    "seeds": [
      "Fractured epiphysis of third metatarsal bone"
    ],
    "gold_answer": "Fragmented epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_01999",
    "question": "What is associated with Phosphoglycerate mutase, muscle, deficiency of?",
    "seeds": [
      "Phosphoglycerate mutase, muscle, deficiency of"
    ],
    "gold_answer": "Muscle spasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02000",
    "question": "What is associated with Auriculocondylar syndrome 4?",
    "seeds": [
      "Auriculocondylar syndrome 4"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02001",
    "question": "What is associated with Increased urine succinate level?",
    "seeds": [
      "Increased urine succinate level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02002",
    "question": "What is associated with Anterior segment dysgenesis 5, multiple subtypes?",
    "seeds": [
      "Anterior segment dysgenesis 5, multiple subtypes"
    ],
    "gold_answer": "PITX2",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02003",
    "question": "What is associated with Intermittent microsaccadic pursuits?",
    "seeds": [
      "Intermittent microsaccadic pursuits"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02004",
    "question": "What is associated with Epileptic encephalopathy?",
    "seeds": [
      "Epileptic encephalopathy"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02005",
    "question": "What is associated with Maternal amniocentesis?",
    "seeds": [
      "Maternal amniocentesis"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02006",
    "question": "What phenotype is associated with Pitt-Hopkins-Like syndrome 2?",
    "seeds": [
      "Pitt-Hopkins-Like syndrome 2"
    ],
    "gold_answer": "Constipation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02007",
    "question": "What phenotype is associated with Carboxypeptidase N deficiency?",
    "seeds": [
      "Carboxypeptidase N deficiency"
    ],
    "gold_answer": "Allergic rhinitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02008",
    "question": "What is associated with Broad middle phalanx of the 2nd toe?",
    "seeds": [
      "Broad middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Broad phalanx of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02009",
    "question": "What is associated with Sulfite oxidase deficiency?",
    "seeds": [
      "Sulfite oxidase deficiency"
    ],
    "gold_answer": "Abnormality of dental eruption",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02010",
    "question": "What phenotype is associated with Epilepsy with grand mal seizures on awakening?",
    "seeds": [
      "Epilepsy with grand mal seizures on awakening"
    ],
    "gold_answer": "Generalized myoclonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02011",
    "question": "What is associated with Sleep walking?",
    "seeds": [
      "Sleep walking"
    ],
    "gold_answer": "Parasomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02012",
    "question": "What is associated with Patchy sclerosis of proximal toe phalanx?",
    "seeds": [
      "Patchy sclerosis of proximal toe phalanx"
    ],
    "gold_answer": "Patchy sclerosis of toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02013",
    "question": "What is associated with Postural hypotension with compensatory tachycardia?",
    "seeds": [
      "Postural hypotension with compensatory tachycardia"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02014",
    "question": "What phenotype is associated with Microcephalic primordial dwarfism, Montreal type?",
    "seeds": [
      "Microcephalic primordial dwarfism, Montreal type"
    ],
    "gold_answer": "Open bite",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02015",
    "question": "What is associated with Reduced muscle fiber delta sarcoglycan?",
    "seeds": [
      "Reduced muscle fiber delta sarcoglycan"
    ],
    "gold_answer": "Abnormal muscle fiber protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02016",
    "question": "What is associated with Increased rate of premature chromosome condensation?",
    "seeds": [
      "Increased rate of premature chromosome condensation"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02017",
    "question": "What phenotype is associated with Peroxisome biogenesis disorder 4A (Zellweger)?",
    "seeds": [
      "Peroxisome biogenesis disorder 4A (Zellweger)"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02018",
    "question": "What is associated with Morning myoclonic jerks?",
    "seeds": [
      "Morning myoclonic jerks"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02019",
    "question": "What phenotype is associated with Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related?",
    "seeds": [
      "Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related"
    ],
    "gold_answer": "Rigidity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02020",
    "question": "What phenotype is associated with Triphalangeal thumb, nonopposable?",
    "seeds": [
      "Triphalangeal thumb, nonopposable"
    ],
    "gold_answer": "Triphalangeal thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02021",
    "question": "What is associated with Orofacial cleft 3?",
    "seeds": [
      "Orofacial cleft 3"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02022",
    "question": "What is associated with Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive?",
    "seeds": [
      "Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02023",
    "question": "What is associated with Agammaglobulinemia 1, autosomal recessive?",
    "seeds": [
      "Agammaglobulinemia 1, autosomal recessive"
    ],
    "gold_answer": "Abnormal large intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02024",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 23?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 23"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02025",
    "question": "What is associated with Cleft soft palate?",
    "seeds": [
      "Cleft soft palate"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02026",
    "question": "What is associated with Macular edema, cystoid?",
    "seeds": [
      "Macular edema, cystoid"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02027",
    "question": "What is associated with Focal impaired awareness seizure?",
    "seeds": [
      "Focal impaired awareness seizure"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02028",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy with spike-wave activation in sleep?",
    "seeds": [
      "Developmental and epileptic encephalopathy with spike-wave activation in sleep"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02029",
    "question": "What phenotype is associated with Epidermodysplasia verruciformis 2?",
    "seeds": [
      "Epidermodysplasia verruciformis 2"
    ],
    "gold_answer": "Verruca plana",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02030",
    "question": "What is associated with Flame-shaped retinal hemorrhage?",
    "seeds": [
      "Flame-shaped retinal hemorrhage"
    ],
    "gold_answer": "Intraretinal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02031",
    "question": "What is associated with Anonychia-microcephaly syndrome?",
    "seeds": [
      "Anonychia-microcephaly syndrome"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02032",
    "question": "What is associated with Microcephalic osteodysplastic primordial dwarfism type II?",
    "seeds": [
      "Microcephalic osteodysplastic primordial dwarfism type II"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02033",
    "question": "What is associated with Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level?",
    "seeds": [
      "Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02034",
    "question": "What phenotype is associated with Refractory celiac disease?",
    "seeds": [
      "Refractory celiac disease"
    ],
    "gold_answer": "Normocytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02035",
    "question": "What is associated with Spinocerebellar ataxia, X-linked 5?",
    "seeds": [
      "Spinocerebellar ataxia, X-linked 5"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02036",
    "question": "What phenotype is associated with Myotonia permanens?",
    "seeds": [
      "Myotonia permanens"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02037",
    "question": "What is associated with Elevated circulating C5 acylcarnitine concentration?",
    "seeds": [
      "Elevated circulating C5 acylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02038",
    "question": "What is associated with Bronchiectasis with or without elevated sweat chloride 2?",
    "seeds": [
      "Bronchiectasis with or without elevated sweat chloride 2"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02039",
    "question": "What is associated with Trismus?",
    "seeds": [
      "Trismus"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02040",
    "question": "What phenotype is associated with Deafness, autosomal dominant 68?",
    "seeds": [
      "Deafness, autosomal dominant 68"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02041",
    "question": "What is associated with Pituitary carcinoma?",
    "seeds": [
      "Pituitary carcinoma"
    ],
    "gold_answer": "Abnormal pituitary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02042",
    "question": "What is associated with Charcot-Marie-Tooth disease, type 4A?",
    "seeds": [
      "Charcot-Marie-Tooth disease, type 4A"
    ],
    "gold_answer": "Abnormal motor nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02043",
    "question": "What is associated with Corner fragments of ulnar metaphysis?",
    "seeds": [
      "Corner fragments of ulnar metaphysis"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02044",
    "question": "What is associated with Hypotonia?",
    "seeds": [
      "Hypotonia"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02045",
    "question": "What is associated with Tethered cord?",
    "seeds": [
      "Tethered cord"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02046",
    "question": "What is associated with Pancreatic cysts?",
    "seeds": [
      "Pancreatic cysts"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02047",
    "question": "What is associated with Abnormal forearm bone morphology?",
    "seeds": [
      "Abnormal forearm bone morphology"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02048",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 3?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 3"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02049",
    "question": "What is associated with Increased mean corpuscular volume?",
    "seeds": [
      "Increased mean corpuscular volume"
    ],
    "gold_answer": "Abnormal mean corpuscular volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02050",
    "question": "What is associated with Enhancement of the C-reflex?",
    "seeds": [
      "Enhancement of the C-reflex"
    ],
    "gold_answer": "Abnormality of peripheral nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02051",
    "question": "What is associated with Chromosome 16p12.1 deletion syndrome, 520-kbfragile site 16p12, included?",
    "seeds": [
      "Chromosome 16p12.1 deletion syndrome, 520-kbfragile site 16p12, included"
    ],
    "gold_answer": "Hypoplastic ventricle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02052",
    "question": "What phenotype is associated with Epilepsy, juvenile absence?",
    "seeds": [
      "Epilepsy, juvenile absence"
    ],
    "gold_answer": "Generalized myoclonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02053",
    "question": "What is associated with Peripheral retinal atrophy?",
    "seeds": [
      "Peripheral retinal atrophy"
    ],
    "gold_answer": "Retinal atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02054",
    "question": "What is associated with Stippling of the epiphyses of the 4th finger?",
    "seeds": [
      "Stippling of the epiphyses of the 4th finger"
    ],
    "gold_answer": "Epiphyseal stippling of finger phalanges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02055",
    "question": "What phenotype is associated with Leprosy?",
    "seeds": [
      "Leprosy"
    ],
    "gold_answer": "Uveitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02056",
    "question": "What is associated with Uterine leiomyosarcoma?",
    "seeds": [
      "Uterine leiomyosarcoma"
    ],
    "gold_answer": "Uterine neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02057",
    "question": "What phenotype is associated with Van Maldergem syndrome 1?",
    "seeds": [
      "Van Maldergem syndrome 1"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02058",
    "question": "What is associated with Irregular epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Irregular epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02059",
    "question": "What phenotype is associated with Acyl-Coa dehydrogenase, medium-chain, deficiency of?",
    "seeds": [
      "Acyl-Coa dehydrogenase, medium-chain, deficiency of"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02060",
    "question": "What is associated with Phosphaturic mesenchymal tumor?",
    "seeds": [
      "Phosphaturic mesenchymal tumor"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02061",
    "question": "What is associated with Joint contracture of the 3rd finger?",
    "seeds": [
      "Joint contracture of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02062",
    "question": "What is associated with Milky appearance of bronchoalveolar lavage fluid?",
    "seeds": [
      "Milky appearance of bronchoalveolar lavage fluid"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02063",
    "question": "What phenotype is associated with Alpha-N-acetylgalactosaminidase deficiency type 1?",
    "seeds": [
      "Alpha-N-acetylgalactosaminidase deficiency type 1"
    ],
    "gold_answer": "Autism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02064",
    "question": "What is associated with Hyperphenylalaninemia, MILD, non-bh4-deficient?",
    "seeds": [
      "Hyperphenylalaninemia, MILD, non-bh4-deficient"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02065",
    "question": "What phenotype is associated with Drug-induced lupus erythematosus?",
    "seeds": [
      "Drug-induced lupus erythematosus"
    ],
    "gold_answer": "Pericardial effusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02066",
    "question": "What is associated with Subcortical white matter calcifications?",
    "seeds": [
      "Subcortical white matter calcifications"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02067",
    "question": "What is associated with Leber congenital amaurosis 19?",
    "seeds": [
      "Leber congenital amaurosis 19"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02068",
    "question": "What is associated with Machado-Joseph disease type 2?",
    "seeds": [
      "Machado-Joseph disease type 2"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02069",
    "question": "What is associated with Acroparesthesia?",
    "seeds": [
      "Acroparesthesia"
    ],
    "gold_answer": "Somatic sensory dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02070",
    "question": "What is associated with Pseudohypoaldosteronism, type IIE?",
    "seeds": [
      "Pseudohypoaldosteronism, type IIE"
    ],
    "gold_answer": "Increased blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02071",
    "question": "What phenotype is associated with Autosomal dominant spastic paraplegia type 6?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 6"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02072",
    "question": "What is associated with Myelodysplastic neoplasm with low blasts?",
    "seeds": [
      "Myelodysplastic neoplasm with low blasts"
    ],
    "gold_answer": "Abnormal total neutrophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02073",
    "question": "What phenotype is associated with Wilms tumor 1?",
    "seeds": [
      "Wilms tumor 1"
    ],
    "gold_answer": "Nephroblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02074",
    "question": "What is associated with Paradoxical respiration?",
    "seeds": [
      "Paradoxical respiration"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02075",
    "question": "What is associated with Flaring of lower rib cage?",
    "seeds": [
      "Flaring of lower rib cage"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02076",
    "question": "What is associated with Periodic fever, menstrual cycle-dependent?",
    "seeds": [
      "Periodic fever, menstrual cycle-dependent"
    ],
    "gold_answer": "Abnormality of temperature regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02077",
    "question": "What is associated with Isolated Klippel-Feil syndrome?",
    "seeds": [
      "Isolated Klippel-Feil syndrome"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02078",
    "question": "What phenotype is associated with Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy?",
    "seeds": [
      "Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy"
    ],
    "gold_answer": "Bilateral tonic-clonic seizure with generalized onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02079",
    "question": "What is associated with Cone-shaped epiphysis of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Cone-shaped epiphysis of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02080",
    "question": "What is associated with Increased corneal thickness?",
    "seeds": [
      "Increased corneal thickness"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02081",
    "question": "What is associated with Retinal vasculitis?",
    "seeds": [
      "Retinal vasculitis"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02082",
    "question": "What is associated with Accessory navicular bone?",
    "seeds": [
      "Accessory navicular bone"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02083",
    "question": "What is associated with ALG6-CDG?",
    "seeds": [
      "ALG6-CDG"
    ],
    "gold_answer": "Short phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02084",
    "question": "What is associated with Multiple mitochondrial dysfunctions syndrome 5?",
    "seeds": [
      "Multiple mitochondrial dysfunctions syndrome 5"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02085",
    "question": "What is associated with Microphthalmia, syndromic 11?",
    "seeds": [
      "Microphthalmia, syndromic 11"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02086",
    "question": "What is associated with Irregular respiration?",
    "seeds": [
      "Irregular respiration"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02087",
    "question": "What is associated with Age-related nuclear cataract?",
    "seeds": [
      "Age-related nuclear cataract"
    ],
    "gold_answer": "Age-related cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02088",
    "question": "What is associated with Chromosome 8q22.1 duplication syndrome?",
    "seeds": [
      "Chromosome 8q22.1 duplication syndrome"
    ],
    "gold_answer": "Abnormal palm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02089",
    "question": "What is associated with Short stature-deafness-neutrophil dysfunction-dysmorphism syndrome?",
    "seeds": [
      "Short stature-deafness-neutrophil dysfunction-dysmorphism syndrome"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02090",
    "question": "What is associated with Immunoglobulin A vasculitis?",
    "seeds": [
      "Immunoglobulin A vasculitis"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02091",
    "question": "What is associated with Leydig cell hypoplasia due to complete LH resistance?",
    "seeds": [
      "Leydig cell hypoplasia due to complete LH resistance"
    ],
    "gold_answer": "LHCGR",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_02092",
    "question": "What is associated with Abnormal cerebral artery morphology?",
    "seeds": [
      "Abnormal cerebral artery morphology"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02093",
    "question": "What is associated with Aicardi-Goutieres syndrome 4?",
    "seeds": [
      "Aicardi-Goutieres syndrome 4"
    ],
    "gold_answer": "Intracranial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02094",
    "question": "What is associated with Palmomental reflex?",
    "seeds": [
      "Palmomental reflex"
    ],
    "gold_answer": "Primitive reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02095",
    "question": "What is associated with Infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome?",
    "seeds": [
      "Infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome"
    ],
    "gold_answer": "SYT1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02096",
    "question": "What is associated with Amyotrophy of the musculature of the pelvis?",
    "seeds": [
      "Amyotrophy of the musculature of the pelvis"
    ],
    "gold_answer": "Pelvic girdle muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02097",
    "question": "What is associated with Orthostatic tachycardia?",
    "seeds": [
      "Orthostatic tachycardia"
    ],
    "gold_answer": "Abnormality of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02098",
    "question": "What is associated with Glutaric aciduria III?",
    "seeds": [
      "Glutaric aciduria III"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02099",
    "question": "What is associated with Cervical spinal canal stenosis?",
    "seeds": [
      "Cervical spinal canal stenosis"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02100",
    "question": "What is associated with Diabetic embryopathy?",
    "seeds": [
      "Diabetic embryopathy"
    ],
    "gold_answer": "Conotruncal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02101",
    "question": "What is associated with Abnormal tricuspid valve leaflet morphology?",
    "seeds": [
      "Abnormal tricuspid valve leaflet morphology"
    ],
    "gold_answer": "Abnormal tricuspid valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02102",
    "question": "What is associated with Trichomegaly?",
    "seeds": [
      "Trichomegaly"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02103",
    "question": "What is associated with Delayed eruption of primary teeth?",
    "seeds": [
      "Delayed eruption of primary teeth"
    ],
    "gold_answer": "Abnormality of primary teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02104",
    "question": "What is associated with Abnormal tricuspid valve annulus morphology?",
    "seeds": [
      "Abnormal tricuspid valve annulus morphology"
    ],
    "gold_answer": "Abnormal tricuspid valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02105",
    "question": "What is associated with Perinephric fluid collection?",
    "seeds": [
      "Perinephric fluid collection"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02106",
    "question": "What is associated with Miscarriage?",
    "seeds": [
      "Miscarriage"
    ],
    "gold_answer": "Prenatal death",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02107",
    "question": "What is associated with Prelingual sensorineural hearing impairment?",
    "seeds": [
      "Prelingual sensorineural hearing impairment"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02108",
    "question": "What is associated with Abnormal digestive system morphology?",
    "seeds": [
      "Abnormal digestive system morphology"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02109",
    "question": "What is associated with Spasticity?",
    "seeds": [
      "Spasticity"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02110",
    "question": "What is associated with Aplasia of the 2nd metacarpal?",
    "seeds": [
      "Aplasia of the 2nd metacarpal"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the 2nd metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02111",
    "question": "What is associated with Retroperitoneal mass?",
    "seeds": [
      "Retroperitoneal mass"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02112",
    "question": "What is associated with Tracheomegaly?",
    "seeds": [
      "Tracheomegaly"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02113",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 41?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 41"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02114",
    "question": "What is associated with Abnormal proerythroblast morphology?",
    "seeds": [
      "Abnormal proerythroblast morphology"
    ],
    "gold_answer": "Abnormal erythroid lineage cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02115",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanges of the hand?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02116",
    "question": "What is associated with Ankylosing vertebral hyperostosis with tylosis?",
    "seeds": [
      "Ankylosing vertebral hyperostosis with tylosis"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02117",
    "question": "What is associated with Acute erythroid leukemia?",
    "seeds": [
      "Acute erythroid leukemia"
    ],
    "gold_answer": "Abnormal circulating IgM concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02118",
    "question": "What is associated with Intellectual developmental disorder with impaired language and dysmorphic facies?",
    "seeds": [
      "Intellectual developmental disorder with impaired language and dysmorphic facies"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02119",
    "question": "What is associated with Rare autosomal recessive non-syndromic sensorineural deafness type DFNB?",
    "seeds": [
      "Rare autosomal recessive non-syndromic sensorineural deafness type DFNB"
    ],
    "gold_answer": "EPS8L2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02120",
    "question": "What is associated with Elevated circulating CCL3 concentration?",
    "seeds": [
      "Elevated circulating CCL3 concentration"
    ],
    "gold_answer": "Abnormal circulating chemokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02121",
    "question": "What is associated with Abnormal capillary morphology?",
    "seeds": [
      "Abnormal capillary morphology"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02122",
    "question": "What is associated with Hypotonia with lactic acidemia and hyperammonemia?",
    "seeds": [
      "Hypotonia with lactic acidemia and hyperammonemia"
    ],
    "gold_answer": "MRPS22",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02123",
    "question": "What is associated with IMAGe syndrome?",
    "seeds": [
      "IMAGe syndrome"
    ],
    "gold_answer": "Abnormal frontal bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02124",
    "question": "What phenotype is associated with Cree impaired intellectual development syndrome?",
    "seeds": [
      "Cree impaired intellectual development syndrome"
    ],
    "gold_answer": "Coloboma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02125",
    "question": "What is associated with Solitary angiokeratoma?",
    "seeds": [
      "Solitary angiokeratoma"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02126",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 40?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 40"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02127",
    "question": "What is associated with Progressive familial heart block, type II?",
    "seeds": [
      "Progressive familial heart block, type II"
    ],
    "gold_answer": "Third degree atrioventricular block",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02128",
    "question": "What is associated with Hydrocele testis?",
    "seeds": [
      "Hydrocele testis"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02129",
    "question": "What is associated with Joint subluxation?",
    "seeds": [
      "Joint subluxation"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02130",
    "question": "What is associated with Myeloproliferative disorder?",
    "seeds": [
      "Myeloproliferative disorder"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02131",
    "question": "What is associated with Chronic noninfectious lymphadenopathy?",
    "seeds": [
      "Chronic noninfectious lymphadenopathy"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02132",
    "question": "What is associated with Abnormal manual kinetic perimetry test?",
    "seeds": [
      "Abnormal manual kinetic perimetry test"
    ],
    "gold_answer": "Abnormal visual field test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02133",
    "question": "What phenotype is associated with Variegate porphyria, childhood-onset?",
    "seeds": [
      "Variegate porphyria, childhood-onset"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02134",
    "question": "What is associated with Sclerosis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Sclerosis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Sclerosis of distal phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02135",
    "question": "What is associated with Enterocutaneous fistula?",
    "seeds": [
      "Enterocutaneous fistula"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02136",
    "question": "What is associated with Flared, irregular rib ends?",
    "seeds": [
      "Flared, irregular rib ends"
    ],
    "gold_answer": "Cupped ribs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02137",
    "question": "What phenotype is associated with Thrombophilia due to deficiency of activated protein C cofactor?",
    "seeds": [
      "Thrombophilia due to deficiency of activated protein C cofactor"
    ],
    "gold_answer": "Resistance to activated protein C",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02138",
    "question": "What is associated with Proximal biceps tendon rupture?",
    "seeds": [
      "Proximal biceps tendon rupture"
    ],
    "gold_answer": "Tendon rupture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02139",
    "question": "What phenotype is associated with Facial clefting, oblique, 1?",
    "seeds": [
      "Facial clefting, oblique, 1"
    ],
    "gold_answer": "Cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02140",
    "question": "What phenotype is associated with Leydig cell hypoplasia?",
    "seeds": [
      "Leydig cell hypoplasia"
    ],
    "gold_answer": "Hypergonadotropic hypogonadism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02141",
    "question": "What is associated with Retinopathy of prematurity threshold?",
    "seeds": [
      "Retinopathy of prematurity threshold"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02142",
    "question": "What is associated with X-linked intellectual disability, Stevenson type?",
    "seeds": [
      "X-linked intellectual disability, Stevenson type"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02143",
    "question": "What is associated with Lack of insight?",
    "seeds": [
      "Lack of insight"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02144",
    "question": "What is associated with Hypoinsulinemic hypoglycemia and body hemihypertrophy?",
    "seeds": [
      "Hypoinsulinemic hypoglycemia and body hemihypertrophy"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02145",
    "question": "What is associated with Fractured proximal phalanx of manual digit 1?",
    "seeds": [
      "Fractured proximal phalanx of manual digit 1"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02146",
    "question": "What is associated with Abnormal lymph node cell composition?",
    "seeds": [
      "Abnormal lymph node cell composition"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02147",
    "question": "What is associated with Alpha-methylacetoacetic aciduria?",
    "seeds": [
      "Alpha-methylacetoacetic aciduria"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02148",
    "question": "What is associated with Short middle phalanx of the 3rd finger?",
    "seeds": [
      "Short middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02149",
    "question": "What phenotype is associated with Congenital sucrase-isomaltase deficiency?",
    "seeds": [
      "Congenital sucrase-isomaltase deficiency"
    ],
    "gold_answer": "Poor appetite",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02150",
    "question": "What is associated with Spinocerebellar ataxia 14?",
    "seeds": [
      "Spinocerebellar ataxia 14"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02151",
    "question": "What is associated with Fragmented finger phalanx epiphysis?",
    "seeds": [
      "Fragmented finger phalanx epiphysis"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02152",
    "question": "What is associated with Demonstration of Leishmania in tissue?",
    "seeds": [
      "Demonstration of Leishmania in tissue"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02153",
    "question": "What phenotype is associated with Cystic hamartoma of lung and kidney?",
    "seeds": [
      "Cystic hamartoma of lung and kidney"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02154",
    "question": "What phenotype is associated with Bulbar palsy, progressive, of childhood?",
    "seeds": [
      "Bulbar palsy, progressive, of childhood"
    ],
    "gold_answer": "Ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02155",
    "question": "What phenotype is associated with Retinitis pigmentosa 47?",
    "seeds": [
      "Retinitis pigmentosa 47"
    ],
    "gold_answer": "Decreased light- and dark-adapted electroretinogram amplitude",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02156",
    "question": "What phenotype is associated with Muscular dystrophy, limb-girdle, autosomal recessive 21?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, autosomal recessive 21"
    ],
    "gold_answer": "Loss of ambulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02157",
    "question": "What is associated with Bull's eye rash?",
    "seeds": [
      "Bull's eye rash"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02158",
    "question": "What is associated with Abnormal circulating calcium concentration?",
    "seeds": [
      "Abnormal circulating calcium concentration"
    ],
    "gold_answer": "Abnormal blood ion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02159",
    "question": "What is associated with Feingold syndrome 1?",
    "seeds": [
      "Feingold syndrome 1"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02160",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies, type A, 11)?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies, type A, 11)"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02161",
    "question": "What is associated with Abnormal proportion of exhausted T cells?",
    "seeds": [
      "Abnormal proportion of exhausted T cells"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02162",
    "question": "What is associated with Mild expressive language delay?",
    "seeds": [
      "Mild expressive language delay"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02163",
    "question": "What phenotype is associated with Mosaic trisomy 14 syndrome?",
    "seeds": [
      "Mosaic trisomy 14 syndrome"
    ],
    "gold_answer": "Hypoplastic helices",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02164",
    "question": "What is associated with Ossifying fibroma?",
    "seeds": [
      "Ossifying fibroma"
    ],
    "gold_answer": "Sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02165",
    "question": "What is associated with Mastoiditis?",
    "seeds": [
      "Mastoiditis"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02166",
    "question": "What is associated with Cone-shaped epiphyses of the middle phalanges of the hand?",
    "seeds": [
      "Cone-shaped epiphyses of the middle phalanges of the hand"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02167",
    "question": "What phenotype is associated with Pseudohypoaldosteronism, type I, autosomal dominant?",
    "seeds": [
      "Pseudohypoaldosteronism, type I, autosomal dominant"
    ],
    "gold_answer": "Hypotension",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02168",
    "question": "What is associated with Abnormal CSF neopterin concentration?",
    "seeds": [
      "Abnormal CSF neopterin concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02169",
    "question": "What phenotype is associated with Cortical dysplasia, complex, with other brain malformations 7?",
    "seeds": [
      "Cortical dysplasia, complex, with other brain malformations 7"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02170",
    "question": "What is associated with Ivory epiphyses of the 4th toe?",
    "seeds": [
      "Ivory epiphyses of the 4th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02171",
    "question": "What is associated with Supravalvar pulmonary stenosis?",
    "seeds": [
      "Supravalvar pulmonary stenosis"
    ],
    "gold_answer": "Pulmonic stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02172",
    "question": "What is associated with Microcephaly, short stature, and impaired glucose metabolism 2?",
    "seeds": [
      "Microcephaly, short stature, and impaired glucose metabolism 2"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02173",
    "question": "What is associated with Anetoderma?",
    "seeds": [
      "Anetoderma"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02174",
    "question": "What is associated with Presenile cataracts?",
    "seeds": [
      "Presenile cataracts"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02175",
    "question": "What is associated with Lack of interest in peers?",
    "seeds": [
      "Lack of interest in peers"
    ],
    "gold_answer": "Abnormal social behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02176",
    "question": "What is associated with Osteolytic defects of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Osteolytic defects of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the proximal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02177",
    "question": "What is associated with Abnormal localization of kidney?",
    "seeds": [
      "Abnormal localization of kidney"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02178",
    "question": "What is associated with Abnormality of the middle ear ossicles?",
    "seeds": [
      "Abnormality of the middle ear ossicles"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02179",
    "question": "What is associated with Combined oxidative phosphorylation defect type 13?",
    "seeds": [
      "Combined oxidative phosphorylation defect type 13"
    ],
    "gold_answer": "Muscle fiber atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02180",
    "question": "What is associated with Very low visual acuity?",
    "seeds": [
      "Very low visual acuity"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02181",
    "question": "What is associated with Mortality/Aging?",
    "seeds": [
      "Mortality/Aging"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02182",
    "question": "What is associated with Horizontal incomitant strabismus?",
    "seeds": [
      "Horizontal incomitant strabismus"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02183",
    "question": "What is associated with Increased CSF isoleucine concentration?",
    "seeds": [
      "Increased CSF isoleucine concentration"
    ],
    "gold_answer": "Abnormal CSF isoleucine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02184",
    "question": "What is associated with Bartter syndrome?",
    "seeds": [
      "Bartter syndrome"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02185",
    "question": "What is associated with Absent epiphysis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Absent epiphysis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02186",
    "question": "What phenotype is associated with Thrombotic thrombocytopenic purpura, hereditary?",
    "seeds": [
      "Thrombotic thrombocytopenic purpura, hereditary"
    ],
    "gold_answer": "Confusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02187",
    "question": "What is associated with Lumbosacral meningocele?",
    "seeds": [
      "Lumbosacral meningocele"
    ],
    "gold_answer": "Abnormal lumbar spine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02188",
    "question": "What phenotype is associated with Atrial fibrillation, familial, 7?",
    "seeds": [
      "Atrial fibrillation, familial, 7"
    ],
    "gold_answer": "Paroxysmal atrial fibrillation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02189",
    "question": "What is associated with Ceroid lipofuscinosis, neuronal, 8?",
    "seeds": [
      "Ceroid lipofuscinosis, neuronal, 8"
    ],
    "gold_answer": "Inability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02190",
    "question": "What is associated with Compression-fractured vertebra?",
    "seeds": [
      "Compression-fractured vertebra"
    ],
    "gold_answer": "Fractured vertebra",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02191",
    "question": "What is associated with Fascial dystrophy, congenital?",
    "seeds": [
      "Fascial dystrophy, congenital"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02192",
    "question": "What is associated with Overlapping fingers?",
    "seeds": [
      "Overlapping fingers"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02193",
    "question": "What is associated with Fetal barbiturate exposure?",
    "seeds": [
      "Fetal barbiturate exposure"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02194",
    "question": "What is associated with Retinitis pigmentosa 95?",
    "seeds": [
      "Retinitis pigmentosa 95"
    ],
    "gold_answer": "Abnormal retinal pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02195",
    "question": "What is associated with Unicoronal synostosis?",
    "seeds": [
      "Unicoronal synostosis"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02196",
    "question": "What is associated with Xeroderma pigmentosum, group C?",
    "seeds": [
      "Xeroderma pigmentosum, group C"
    ],
    "gold_answer": "Melanoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02197",
    "question": "What is associated with Faciomandibular myoclonus, nocturnal?",
    "seeds": [
      "Faciomandibular myoclonus, nocturnal"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02198",
    "question": "What is associated with Sclerosis of 4th toe phalanx?",
    "seeds": [
      "Sclerosis of 4th toe phalanx"
    ],
    "gold_answer": "Increased bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02199",
    "question": "What is associated with Normal interictal EEG?",
    "seeds": [
      "Normal interictal EEG"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02200",
    "question": "What is associated with Synostosis involving bones of the hand?",
    "seeds": [
      "Synostosis involving bones of the hand"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02201",
    "question": "What phenotype is associated with Isolated humero-radial synostosis?",
    "seeds": [
      "Isolated humero-radial synostosis"
    ],
    "gold_answer": "Tarsal synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02202",
    "question": "What is associated with Elevated circulating succinylacetone concentration?",
    "seeds": [
      "Elevated circulating succinylacetone concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02203",
    "question": "What is associated with Decreased RV/TLC ratio?",
    "seeds": [
      "Decreased RV/TLC ratio"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02204",
    "question": "What phenotype is associated with Pontocerebellar hypoplasia type 4?",
    "seeds": [
      "Pontocerebellar hypoplasia type 4"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02205",
    "question": "What is associated with Increased circulating interleukin 18 concentration?",
    "seeds": [
      "Increased circulating interleukin 18 concentration"
    ],
    "gold_answer": "Abnormal immune serum protein physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02206",
    "question": "What is associated with Optic nerve gray crescent?",
    "seeds": [
      "Optic nerve gray crescent"
    ],
    "gold_answer": "Optic disc pallor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02207",
    "question": "What is associated with Hoyeraal-Hreidarsson syndrome?",
    "seeds": [
      "Hoyeraal-Hreidarsson syndrome"
    ],
    "gold_answer": "DKC1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02208",
    "question": "What is associated with Abnormal muscle fiber delta sarcoglycan?",
    "seeds": [
      "Abnormal muscle fiber delta sarcoglycan"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02209",
    "question": "What phenotype is associated with Intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies?",
    "seeds": [
      "Intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02210",
    "question": "What is associated with Blepharophimosis, epicanthus inversus, and ptosis?",
    "seeds": [
      "Blepharophimosis, epicanthus inversus, and ptosis"
    ],
    "gold_answer": "Abnormality of the pubic hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02211",
    "question": "What phenotype is associated with Leukemia, acute myelocytic, with polyposis coli and colon cancer?",
    "seeds": [
      "Leukemia, acute myelocytic, with polyposis coli and colon cancer"
    ],
    "gold_answer": "Colon cancer",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02212",
    "question": "What is associated with Triphalangeal thumb?",
    "seeds": [
      "Triphalangeal thumb"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02213",
    "question": "What phenotype is associated with Autosomal recessive distal osteolysis syndrome?",
    "seeds": [
      "Autosomal recessive distal osteolysis syndrome"
    ],
    "gold_answer": "Osteolysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02214",
    "question": "What is associated with Danubian endemic familial nephropathy?",
    "seeds": [
      "Danubian endemic familial nephropathy"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02215",
    "question": "What is associated with Sorbitol ingestion?",
    "seeds": [
      "Sorbitol ingestion"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02216",
    "question": "What is associated with Otitis media, susceptibility to?",
    "seeds": [
      "Otitis media, susceptibility to"
    ],
    "gold_answer": "Otitis media",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02217",
    "question": "What is associated with Alopecia universalis?",
    "seeds": [
      "Alopecia universalis"
    ],
    "gold_answer": "Increased blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02218",
    "question": "What phenotype is associated with Cortical dysplasia, complex, with other brain malformations 11?",
    "seeds": [
      "Cortical dysplasia, complex, with other brain malformations 11"
    ],
    "gold_answer": "High, narrow palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02219",
    "question": "What phenotype is associated with Amyotrophic lateral sclerosis 18?",
    "seeds": [
      "Amyotrophic lateral sclerosis 18"
    ],
    "gold_answer": "Weight loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02220",
    "question": "What is associated with Altered location of the longitudinal column in the fibrous sheath?",
    "seeds": [
      "Altered location of the longitudinal column in the fibrous sheath"
    ],
    "gold_answer": "Abnormal male germ cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02221",
    "question": "What phenotype is associated with Glaucoma 1, open angle, P?",
    "seeds": [
      "Glaucoma 1, open angle, P"
    ],
    "gold_answer": "Open angle glaucoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02222",
    "question": "What is associated with Abnormality of the epiphysis of the 1st metatarsal?",
    "seeds": [
      "Abnormality of the epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Abnormality of the epiphyses of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02223",
    "question": "What is associated with Familial steroid-resistant nephrotic syndrome with adrenal insufficiency?",
    "seeds": [
      "Familial steroid-resistant nephrotic syndrome with adrenal insufficiency"
    ],
    "gold_answer": "SGPL1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02224",
    "question": "What is associated with Migraine with or without aura, susceptibility to, 12?",
    "seeds": [
      "Migraine with or without aura, susceptibility to, 12"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02225",
    "question": "What is associated with Peritoneal mesothelioma?",
    "seeds": [
      "Peritoneal mesothelioma"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02226",
    "question": "What is associated with Lack of gonadotropin-releasing hormone pulsatility?",
    "seeds": [
      "Lack of gonadotropin-releasing hormone pulsatility"
    ],
    "gold_answer": "Abnormal gonadotropin-releasing hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02227",
    "question": "What is associated with Irregular epiphysis of the distal phalanx of the 4th finger?",
    "seeds": [
      "Irregular epiphysis of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02228",
    "question": "What is associated with Complete duplication of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Complete duplication of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Duplication of phalanx of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02229",
    "question": "What phenotype is associated with Microtia-eye coloboma-imperforation of the nasolacrimal duct syndrome?",
    "seeds": [
      "Microtia-eye coloboma-imperforation of the nasolacrimal duct syndrome"
    ],
    "gold_answer": "Anterior hypopituitarism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02230",
    "question": "What is associated with Drug-induced anaphylaxis?",
    "seeds": [
      "Drug-induced anaphylaxis"
    ],
    "gold_answer": "Anaphylactic shock",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02231",
    "question": "What is associated with Atrial standstill?",
    "seeds": [
      "Atrial standstill"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02232",
    "question": "What is associated with Abnormal gastrointestinal tract morphology?",
    "seeds": [
      "Abnormal gastrointestinal tract morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02233",
    "question": "What is associated with Elevated serum-ascites albumin gradient (SAAG)?",
    "seeds": [
      "Elevated serum-ascites albumin gradient (SAAG)"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02234",
    "question": "What is associated with Chordoma?",
    "seeds": [
      "Chordoma"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02235",
    "question": "What is associated with Transient pulmonary infiltrates?",
    "seeds": [
      "Transient pulmonary infiltrates"
    ],
    "gold_answer": "Pulmonary infiltrates",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02236",
    "question": "What is associated with Chromosome 17p13.1 deletion syndrome?",
    "seeds": [
      "Chromosome 17p13.1 deletion syndrome"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02237",
    "question": "What is associated with Abnormal visual field test?",
    "seeds": [
      "Abnormal visual field test"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02238",
    "question": "What is associated with Monophalangy of great toe?",
    "seeds": [
      "Monophalangy of great toe"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02239",
    "question": "What is associated with Arthrogryposis multiplex congenita with whistling face?",
    "seeds": [
      "Arthrogryposis multiplex congenita with whistling face"
    ],
    "gold_answer": "Abnormality of mouth shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02240",
    "question": "What is associated with CNS foam cells?",
    "seeds": [
      "CNS foam cells"
    ],
    "gold_answer": "Arteriosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02241",
    "question": "What phenotype is associated with PAGOD syndrome?",
    "seeds": [
      "PAGOD syndrome"
    ],
    "gold_answer": "Abnormality of the uterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02242",
    "question": "What is associated with Abnormality of the umbilical cord?",
    "seeds": [
      "Abnormality of the umbilical cord"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02243",
    "question": "What is associated with Maldevelopment of radioulnar joint?",
    "seeds": [
      "Maldevelopment of radioulnar joint"
    ],
    "gold_answer": "Abnormal forearm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02244",
    "question": "What is associated with Abnormal sweat electrolytes?",
    "seeds": [
      "Abnormal sweat electrolytes"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02245",
    "question": "What is associated with Alternating exotropia?",
    "seeds": [
      "Alternating exotropia"
    ],
    "gold_answer": "Exodeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02246",
    "question": "What is associated with Fingernail dysplasia?",
    "seeds": [
      "Fingernail dysplasia"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02247",
    "question": "What is associated with Hypertrophic nerve changes?",
    "seeds": [
      "Hypertrophic nerve changes"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02248",
    "question": "What is associated with Rectoureteral fistula?",
    "seeds": [
      "Rectoureteral fistula"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02249",
    "question": "What is associated with Late-onset combined immunodeficiency due to ICOSL deficiency?",
    "seeds": [
      "Late-onset combined immunodeficiency due to ICOSL deficiency"
    ],
    "gold_answer": "ICOSLG",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02250",
    "question": "What is associated with Bor-Duane hydrocephalus contiguous gene syndrome?",
    "seeds": [
      "Bor-Duane hydrocephalus contiguous gene syndrome"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02251",
    "question": "What phenotype is associated with Benign chronic pemphigus?",
    "seeds": [
      "Benign chronic pemphigus"
    ],
    "gold_answer": "Erythema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02252",
    "question": "What is associated with Fragmentation of the epiphysis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Fragmentation of the epiphysis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal distal phalanx morphology of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02253",
    "question": "What is associated with Focal hyperkinetic seizure?",
    "seeds": [
      "Focal hyperkinetic seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02254",
    "question": "What is associated with Erythromelalgia?",
    "seeds": [
      "Erythromelalgia"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02255",
    "question": "What is associated with Retroperitoneal mass?",
    "seeds": [
      "Retroperitoneal mass"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02256",
    "question": "What is associated with Neonatal electro-clinical motor seizure?",
    "seeds": [
      "Neonatal electro-clinical motor seizure"
    ],
    "gold_answer": "Neonatal seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02257",
    "question": "What is associated with Triangular epiphyses of the thumb?",
    "seeds": [
      "Triangular epiphyses of the thumb"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02258",
    "question": "What is associated with Focal impaired awareness cognitive seizure with anomia?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with anomia"
    ],
    "gold_answer": "Focal cognitive seizure with anomia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02259",
    "question": "What phenotype is associated with Intellectual developmental disorder with short stature, facial anomalies, and speech defects?",
    "seeds": [
      "Intellectual developmental disorder with short stature, facial anomalies, and speech defects"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02260",
    "question": "What is associated with Deafness, congenital neurosensory, autosomal recessive 40?",
    "seeds": [
      "Deafness, congenital neurosensory, autosomal recessive 40"
    ],
    "gold_answer": "Childhood onset sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02261",
    "question": "What phenotype is associated with Megalencephalic leukoencephalopathy with subcortical cysts 2A?",
    "seeds": [
      "Megalencephalic leukoencephalopathy with subcortical cysts 2A"
    ],
    "gold_answer": "Megalencephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02262",
    "question": "What is associated with Oblique fracture?",
    "seeds": [
      "Oblique fracture"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02263",
    "question": "What is associated with Growth hormone insensitivity, partial?",
    "seeds": [
      "Growth hormone insensitivity, partial"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02264",
    "question": "What is associated with Thin lower lip vermilion?",
    "seeds": [
      "Thin lower lip vermilion"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02265",
    "question": "What is associated with Premature delivery because of cervical insufficiency or membrane fragility?",
    "seeds": [
      "Premature delivery because of cervical insufficiency or membrane fragility"
    ],
    "gold_answer": "Premature birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02266",
    "question": "What is associated with Adermatoglyphia?",
    "seeds": [
      "Adermatoglyphia"
    ],
    "gold_answer": "Abnormal dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02267",
    "question": "What is associated with Impaired growth-hormone response to insulin stimulation test?",
    "seeds": [
      "Impaired growth-hormone response to insulin stimulation test"
    ],
    "gold_answer": "Abnormal response to insulin tolerance test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02268",
    "question": "What is associated with Unilateral vestibular schwannoma?",
    "seeds": [
      "Unilateral vestibular schwannoma"
    ],
    "gold_answer": "Abnormal cranial nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02269",
    "question": "What is associated with Intoeing?",
    "seeds": [
      "Intoeing"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02270",
    "question": "What is associated with Spastic paraplegia 61, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 61, autosomal recessive"
    ],
    "gold_answer": "Proximal hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02271",
    "question": "What is associated with Abnormal pigmentation of the oral mucosa?",
    "seeds": [
      "Abnormal pigmentation of the oral mucosa"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02272",
    "question": "What is associated with Exudative vitreoretinopathy 5?",
    "seeds": [
      "Exudative vitreoretinopathy 5"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02273",
    "question": "What is associated with Attention deficit hyperactivity disorder?",
    "seeds": [
      "Attention deficit hyperactivity disorder"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02274",
    "question": "What is associated with Subglottic stenosis?",
    "seeds": [
      "Subglottic stenosis"
    ],
    "gold_answer": "Abnormality of the larynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02275",
    "question": "What is associated with Absent hallux?",
    "seeds": [
      "Absent hallux"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02276",
    "question": "What is associated with Absent epiphysis of the 1st metatarsal?",
    "seeds": [
      "Absent epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Abnormality of the epiphysis of the 1st metatarsal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02277",
    "question": "What is associated with Congenital contracture?",
    "seeds": [
      "Congenital contracture"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02278",
    "question": "What is associated with Bronchial diverticula?",
    "seeds": [
      "Bronchial diverticula"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02279",
    "question": "What is associated with Proximal placement of thumb?",
    "seeds": [
      "Proximal placement of thumb"
    ],
    "gold_answer": "Deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02280",
    "question": "What is associated with Radius, aplasia of, with cleft lip/palate?",
    "seeds": [
      "Radius, aplasia of, with cleft lip/palate"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02281",
    "question": "What is associated with Aminopterin/methotrexate embryofetopathy?",
    "seeds": [
      "Aminopterin/methotrexate embryofetopathy"
    ],
    "gold_answer": "Abnormality of the periorbital region",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02282",
    "question": "What is associated with Renal potassium wasting?",
    "seeds": [
      "Renal potassium wasting"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02283",
    "question": "What is associated with Near esotropia?",
    "seeds": [
      "Near esotropia"
    ],
    "gold_answer": "Esotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02284",
    "question": "What is associated with Usher syndrome type 1?",
    "seeds": [
      "Usher syndrome type 1"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02285",
    "question": "What is associated with Brachmann-De lange-like facial changes with microcephaly, metatarsusadductus, and developmental delay?",
    "seeds": [
      "Brachmann-De lange-like facial changes with microcephaly, metatarsusadductus, and developmental delay"
    ],
    "gold_answer": "Abnormal metatarsal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02286",
    "question": "What is associated with Slowed slurred speech?",
    "seeds": [
      "Slowed slurred speech"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02287",
    "question": "What is associated with Narrow philtrum?",
    "seeds": [
      "Narrow philtrum"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02288",
    "question": "What is associated with Ivory epiphyses of the 5th toe?",
    "seeds": [
      "Ivory epiphyses of the 5th toe"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02289",
    "question": "What is associated with Subarterial ventricular septal defect?",
    "seeds": [
      "Subarterial ventricular septal defect"
    ],
    "gold_answer": "Abnormal ventricular septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02290",
    "question": "What is associated with Double depressor palsy?",
    "seeds": [
      "Double depressor palsy"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02291",
    "question": "What is associated with Palmoplantar location?",
    "seeds": [
      "Palmoplantar location"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02292",
    "question": "What phenotype is associated with Deafness, autosomal dominant nonsyndromic sensorineural 11?",
    "seeds": [
      "Deafness, autosomal dominant nonsyndromic sensorineural 11"
    ],
    "gold_answer": "Bilateral sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02293",
    "question": "What is associated with Genetic anticipation with paternal anticipation bias?",
    "seeds": [
      "Genetic anticipation with paternal anticipation bias"
    ],
    "gold_answer": "Genetic anticipation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02294",
    "question": "What is associated with Sleep onset rapid eye movement period?",
    "seeds": [
      "Sleep onset rapid eye movement period"
    ],
    "gold_answer": "Abnormal rapid eye movement sleep",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02295",
    "question": "What is associated with Spermatogenic failure 78?",
    "seeds": [
      "Spermatogenic failure 78"
    ],
    "gold_answer": "Abnormal sperm head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02296",
    "question": "What phenotype is associated with NUT midline carcinoma?",
    "seeds": [
      "NUT midline carcinoma"
    ],
    "gold_answer": "Pancreatoblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02297",
    "question": "What is associated with Tetraploidy syndrome?",
    "seeds": [
      "Tetraploidy syndrome"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02298",
    "question": "What is associated with Fragmentation of the epiphyses of the hallux?",
    "seeds": [
      "Fragmentation of the epiphyses of the hallux"
    ],
    "gold_answer": "Abnormality of the epiphyses of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02299",
    "question": "What is associated with Very long chain fatty acid accumulation?",
    "seeds": [
      "Very long chain fatty acid accumulation"
    ],
    "gold_answer": "Abnormal tissue metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02300",
    "question": "What is associated with Onychogryphosis of toenails?",
    "seeds": [
      "Onychogryphosis of toenails"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02301",
    "question": "What phenotype is associated with Respiratory distress syndrome in premature infants?",
    "seeds": [
      "Respiratory distress syndrome in premature infants"
    ],
    "gold_answer": "Pulmonary edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02302",
    "question": "What is associated with Abnormal morphology of erythroid progenitor cell?",
    "seeds": [
      "Abnormal morphology of erythroid progenitor cell"
    ],
    "gold_answer": "Abnormal bone marrow cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02303",
    "question": "What is associated with Crigler-Najjar syndrome, type II?",
    "seeds": [
      "Crigler-Najjar syndrome, type II"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02304",
    "question": "What is associated with Blepharochalasis, superior?",
    "seeds": [
      "Blepharochalasis, superior"
    ],
    "gold_answer": "Periorbital edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02305",
    "question": "What is associated with Aplasia of the proximal phalanx of the hallux?",
    "seeds": [
      "Aplasia of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Aplasia of the phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02306",
    "question": "What is associated with Absent dermal elastic fibers?",
    "seeds": [
      "Absent dermal elastic fibers"
    ],
    "gold_answer": "Abnormal cutaneous elastic fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02307",
    "question": "What is associated with Endometriosis?",
    "seeds": [
      "Endometriosis"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02308",
    "question": "What is associated with Metabolic ketoacidosis?",
    "seeds": [
      "Metabolic ketoacidosis"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02309",
    "question": "What is associated with Silent hypoxemia?",
    "seeds": [
      "Silent hypoxemia"
    ],
    "gold_answer": "Hypoxemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02310",
    "question": "What phenotype is associated with Deafness, autosomal recessive 101?",
    "seeds": [
      "Deafness, autosomal recessive 101"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02311",
    "question": "What is associated with Flexural reticulate hyperpigmentation?",
    "seeds": [
      "Flexural reticulate hyperpigmentation"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02312",
    "question": "What is associated with Amyloidosis, primary localized cutaneous, 3?",
    "seeds": [
      "Amyloidosis, primary localized cutaneous, 3"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02313",
    "question": "What is associated with Cortical dysplasia, complex, with other brain malformations 14B, (bilateral perisylvian)?",
    "seeds": [
      "Cortical dysplasia, complex, with other brain malformations 14B, (bilateral perisylvian)"
    ],
    "gold_answer": "Heterotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02314",
    "question": "What is associated with Ameliorated by thiamine?",
    "seeds": [
      "Ameliorated by thiamine"
    ],
    "gold_answer": "Ameliorated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02315",
    "question": "What is associated with Persistent pupillary membrane?",
    "seeds": [
      "Persistent pupillary membrane"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02316",
    "question": "What is associated with Epidermolysis bullosa simplex with mottled pigmentation?",
    "seeds": [
      "Epidermolysis bullosa simplex with mottled pigmentation"
    ],
    "gold_answer": "Fragile skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02317",
    "question": "What is associated with Anti-GAD65 antibody?",
    "seeds": [
      "Anti-GAD65 antibody"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02318",
    "question": "What is associated with Decreased RV/TLC ratio?",
    "seeds": [
      "Decreased RV/TLC ratio"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02319",
    "question": "What is associated with Syringomyelia?",
    "seeds": [
      "Syringomyelia"
    ],
    "gold_answer": "Spinal cord lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02320",
    "question": "What is associated with Reduced OCT-measured macular thickness?",
    "seeds": [
      "Reduced OCT-measured macular thickness"
    ],
    "gold_answer": "Abnormal OCT-measured macular thickness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02321",
    "question": "What is associated with Mesangial microfibril deposition?",
    "seeds": [
      "Mesangial microfibril deposition"
    ],
    "gold_answer": "Mesangial fibril deposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02322",
    "question": "What is associated with Duplication of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Duplication of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Duplication of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02323",
    "question": "What is associated with Jung syndrome?",
    "seeds": [
      "Jung syndrome"
    ],
    "gold_answer": "Abnormality of the posterior hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02324",
    "question": "What is associated with Proximal lower limb muscle weakness?",
    "seeds": [
      "Proximal lower limb muscle weakness"
    ],
    "gold_answer": "Limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02325",
    "question": "What is associated with Vogt-Koyanagi-Harada disease?",
    "seeds": [
      "Vogt-Koyanagi-Harada disease"
    ],
    "gold_answer": "Nausea and vomiting",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02326",
    "question": "What is associated with Leber congenital amaurosis 10?",
    "seeds": [
      "Leber congenital amaurosis 10"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02327",
    "question": "What is associated with Increased sialylation of N-linked protein glycosylation?",
    "seeds": [
      "Increased sialylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02328",
    "question": "What is associated with Temporomandibular arthritis?",
    "seeds": [
      "Temporomandibular arthritis"
    ],
    "gold_answer": "Arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02329",
    "question": "What is associated with Abnormal leukocyte physiology?",
    "seeds": [
      "Abnormal leukocyte physiology"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02330",
    "question": "What is associated with Beta-alaninuria?",
    "seeds": [
      "Beta-alaninuria"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02331",
    "question": "What is associated with Increased inflammatory response?",
    "seeds": [
      "Increased inflammatory response"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02332",
    "question": "What is associated with Prominence of the zygomatic bone?",
    "seeds": [
      "Prominence of the zygomatic bone"
    ],
    "gold_answer": "Abnormal zygomatic bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02333",
    "question": "What is associated with Abnormal pituitary stalk morphology?",
    "seeds": [
      "Abnormal pituitary stalk morphology"
    ],
    "gold_answer": "Abnormality of the hypothalamus-pituitary axis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02334",
    "question": "What phenotype is associated with Branchial arch syndrome, X-linked?",
    "seeds": [
      "Branchial arch syndrome, X-linked"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02335",
    "question": "What is associated with Aplasia of the 3rd metacarpal?",
    "seeds": [
      "Aplasia of the 3rd metacarpal"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02336",
    "question": "What is associated with Shoulder labrum tear?",
    "seeds": [
      "Shoulder labrum tear"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02337",
    "question": "What is associated with Functional abnormality of male internal genitalia?",
    "seeds": [
      "Functional abnormality of male internal genitalia"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02338",
    "question": "What is associated with Abnormal fetal skeletal morphology?",
    "seeds": [
      "Abnormal fetal skeletal morphology"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02339",
    "question": "What is associated with Generalized bone demineralization?",
    "seeds": [
      "Generalized bone demineralization"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02340",
    "question": "What phenotype is associated with Hemoglobin E-beta-thalassemia syndrome?",
    "seeds": [
      "Hemoglobin E-beta-thalassemia syndrome"
    ],
    "gold_answer": "Increased circulating ferritin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02341",
    "question": "What is associated with Autosomal recessive myosin storage myopathy?",
    "seeds": [
      "Autosomal recessive myosin storage myopathy"
    ],
    "gold_answer": "MYH7",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02342",
    "question": "What is associated with Prominent nasal septum?",
    "seeds": [
      "Prominent nasal septum"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02343",
    "question": "What is associated with Apneic episodes in infancy?",
    "seeds": [
      "Apneic episodes in infancy"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02344",
    "question": "What is associated with Growth arrest lines?",
    "seeds": [
      "Growth arrest lines"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02345",
    "question": "What is associated with Leukocyte migration defect?",
    "seeds": [
      "Leukocyte migration defect"
    ],
    "gold_answer": "Abnormal leukocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02346",
    "question": "What is associated with Weak grip?",
    "seeds": [
      "Weak grip"
    ],
    "gold_answer": "Hand muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02347",
    "question": "What is associated with Deafness, autosomal dominant 40?",
    "seeds": [
      "Deafness, autosomal dominant 40"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02348",
    "question": "What is associated with Autosomal dominant brachyolmia?",
    "seeds": [
      "Autosomal dominant brachyolmia"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02349",
    "question": "What is associated with Parietal bossing?",
    "seeds": [
      "Parietal bossing"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02350",
    "question": "What is associated with Sertoli cell hypoplasia?",
    "seeds": [
      "Sertoli cell hypoplasia"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02351",
    "question": "What is associated with Glioblastoma multiforme?",
    "seeds": [
      "Glioblastoma multiforme"
    ],
    "gold_answer": "Abnormal glial cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02352",
    "question": "What is associated with Coenzyme Q10 deficiency, primary, 1?",
    "seeds": [
      "Coenzyme Q10 deficiency, primary, 1"
    ],
    "gold_answer": "Abnormal hepatobiliary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02353",
    "question": "What is associated with Infantile dystonia-parkinsonism?",
    "seeds": [
      "Infantile dystonia-parkinsonism"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02354",
    "question": "What is associated with EEG with generalized epileptiform discharges?",
    "seeds": [
      "EEG with generalized epileptiform discharges"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02355",
    "question": "What is associated with Abnormal morphology of the limbic system?",
    "seeds": [
      "Abnormal morphology of the limbic system"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02356",
    "question": "What is associated with Pyruvate dehydrogenase E2 deficiency?",
    "seeds": [
      "Pyruvate dehydrogenase E2 deficiency"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02357",
    "question": "What is associated with Acute myeloid leukemia with t(6;9)(p23;q34)?",
    "seeds": [
      "Acute myeloid leukemia with t(6;9)(p23;q34)"
    ],
    "gold_answer": "NUP214",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_02358",
    "question": "What is associated with Spondyloepiphyseal dysplasia tarda, autosomal recessive?",
    "seeds": [
      "Spondyloepiphyseal dysplasia tarda, autosomal recessive"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02359",
    "question": "What is associated with Intermittent hyperpnea at rest?",
    "seeds": [
      "Intermittent hyperpnea at rest"
    ],
    "gold_answer": "Hyperventilation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02360",
    "question": "What is associated with Benign cephalic histiocytosis?",
    "seeds": [
      "Benign cephalic histiocytosis"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02361",
    "question": "What is associated with Ovarian serous cystadenoma?",
    "seeds": [
      "Ovarian serous cystadenoma"
    ],
    "gold_answer": "Abnormal ovarian morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02362",
    "question": "What phenotype is associated with Neurodevelopmental disorder with central and peripheral motor dysfunction?",
    "seeds": [
      "Neurodevelopmental disorder with central and peripheral motor dysfunction"
    ],
    "gold_answer": "Neonatal respiratory distress",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02363",
    "question": "What phenotype is associated with Weyers ulnar ray/oligodactyly syndrome?",
    "seeds": [
      "Weyers ulnar ray/oligodactyly syndrome"
    ],
    "gold_answer": "Finger aplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02364",
    "question": "What is associated with Hypoplastic fetal nasal bone?",
    "seeds": [
      "Hypoplastic fetal nasal bone"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02365",
    "question": "What phenotype is associated with FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 3?",
    "seeds": [
      "FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 3"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02366",
    "question": "What is associated with Low self-esteem?",
    "seeds": [
      "Low self-esteem"
    ],
    "gold_answer": "Disorder of thought content",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02367",
    "question": "What is associated with Fundus albipunctatus?",
    "seeds": [
      "Fundus albipunctatus"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02368",
    "question": "What is associated with HNRNPA1-related adult-onset distal myopathy?",
    "seeds": [
      "HNRNPA1-related adult-onset distal myopathy"
    ],
    "gold_answer": "Hand muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02369",
    "question": "What is associated with Broad alveolar ridges?",
    "seeds": [
      "Broad alveolar ridges"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02370",
    "question": "What is associated with Adrenogenital syndrome?",
    "seeds": [
      "Adrenogenital syndrome"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02371",
    "question": "What is associated with Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency?",
    "seeds": [
      "Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02372",
    "question": "What is associated with Albinism, oculocutaneous, type IB?",
    "seeds": [
      "Albinism, oculocutaneous, type IB"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02373",
    "question": "What is associated with Breakthrough pain?",
    "seeds": [
      "Breakthrough pain"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02374",
    "question": "What is associated with Anti-insulin antibody positivity?",
    "seeds": [
      "Anti-insulin antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02375",
    "question": "What phenotype is associated with Immunodeficiency, ovarian dysgenesis, and pulmonary fibrosis?",
    "seeds": [
      "Immunodeficiency, ovarian dysgenesis, and pulmonary fibrosis"
    ],
    "gold_answer": "Decreased circulating IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02376",
    "question": "What is associated with Incomplete male pseudohermaphroditism?",
    "seeds": [
      "Incomplete male pseudohermaphroditism"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02377",
    "question": "What is associated with Sinoatrial node dysfunction and deafness?",
    "seeds": [
      "Sinoatrial node dysfunction and deafness"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02378",
    "question": "What phenotype is associated with X-linked centronuclear myopathy?",
    "seeds": [
      "X-linked centronuclear myopathy"
    ],
    "gold_answer": "Feeding difficulties in infancy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02379",
    "question": "What is associated with Large for gestational age?",
    "seeds": [
      "Large for gestational age"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02380",
    "question": "What is associated with Astigmatism?",
    "seeds": [
      "Astigmatism"
    ],
    "gold_answer": "Abnormality of the curvature of the cornea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02381",
    "question": "What is associated with Aplasia of the uterus?",
    "seeds": [
      "Aplasia of the uterus"
    ],
    "gold_answer": "Abnormality of the uterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02382",
    "question": "What is associated with Interlobular septal thickening?",
    "seeds": [
      "Interlobular septal thickening"
    ],
    "gold_answer": "Pulmonary interstitial high-resolution computed tomography abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02383",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked syndromic, Raymond type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic, Raymond type"
    ],
    "gold_answer": "Joint contracture of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02384",
    "question": "What phenotype is associated with Hypomelia with mullerian duct anomalies?",
    "seeds": [
      "Hypomelia with mullerian duct anomalies"
    ],
    "gold_answer": "Uterus didelphys",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02385",
    "question": "What is associated with Leukemia, chronic myeloid?",
    "seeds": [
      "Leukemia, chronic myeloid"
    ],
    "gold_answer": "Decreased circulating alkaline phosphatase activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02386",
    "question": "What is associated with Stiff elbow?",
    "seeds": [
      "Stiff elbow"
    ],
    "gold_answer": "Joint stiffness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02387",
    "question": "What is associated with Increased CD8+ T cell proportion?",
    "seeds": [
      "Increased CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02388",
    "question": "What is associated with Abnormal inner ear morphology?",
    "seeds": [
      "Abnormal inner ear morphology"
    ],
    "gold_answer": "Abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02389",
    "question": "What phenotype is associated with Spastic paralysis, infantile-onset ascending?",
    "seeds": [
      "Spastic paralysis, infantile-onset ascending"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02390",
    "question": "What is associated with Fingerprint body myopathy?",
    "seeds": [
      "Fingerprint body myopathy"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02391",
    "question": "What is associated with Levator-Medial rectus synkinesis?",
    "seeds": [
      "Levator-Medial rectus synkinesis"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02392",
    "question": "What is associated with Twisted gallbladder pedicle?",
    "seeds": [
      "Twisted gallbladder pedicle"
    ],
    "gold_answer": "Abnormal gallbladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02393",
    "question": "What is associated with Abetalipoproteinemia?",
    "seeds": [
      "Abetalipoproteinemia"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02394",
    "question": "What is associated with Abnormal mandible coronoid process morphology?",
    "seeds": [
      "Abnormal mandible coronoid process morphology"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02395",
    "question": "What is associated with Acute tubulointerstitial nephritis?",
    "seeds": [
      "Acute tubulointerstitial nephritis"
    ],
    "gold_answer": "Abnormal tubulointerstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02396",
    "question": "What is associated with Elevated urinary adipic acid?",
    "seeds": [
      "Elevated urinary adipic acid"
    ],
    "gold_answer": "Dicarboxylic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02397",
    "question": "What is associated with Macular dystrophy, vitelliform, 1?",
    "seeds": [
      "Macular dystrophy, vitelliform, 1"
    ],
    "gold_answer": "Yellow/white macular lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02398",
    "question": "What is associated with Uniparental isodisomy?",
    "seeds": [
      "Uniparental isodisomy"
    ],
    "gold_answer": "Mode of inheritance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02399",
    "question": "What phenotype is associated with Tessadori-van Haaften neurodevelopmental syndrome 4?",
    "seeds": [
      "Tessadori-van Haaften neurodevelopmental syndrome 4"
    ],
    "gold_answer": "Camptodactyly of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02400",
    "question": "What is associated with Hyperglycerolemia?",
    "seeds": [
      "Hyperglycerolemia"
    ],
    "gold_answer": "Abnormal circulating carbohydrate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02401",
    "question": "What phenotype is associated with Elsahy-Waters syndrome?",
    "seeds": [
      "Elsahy-Waters syndrome"
    ],
    "gold_answer": "Mandibular prognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02402",
    "question": "What is associated with Reduced tissue type II iodothyronine deiodinase activity?",
    "seeds": [
      "Reduced tissue type II iodothyronine deiodinase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02403",
    "question": "What is associated with Cystic medial necrosis?",
    "seeds": [
      "Cystic medial necrosis"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02404",
    "question": "What is associated with Abnormal peripheral nervous system physiology?",
    "seeds": [
      "Abnormal peripheral nervous system physiology"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02405",
    "question": "What is associated with Congenital atrioventricular dissociation?",
    "seeds": [
      "Congenital atrioventricular dissociation"
    ],
    "gold_answer": "Abnormal atrioventricular conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02406",
    "question": "What is associated with Tracheal calcification?",
    "seeds": [
      "Tracheal calcification"
    ],
    "gold_answer": "Ectopic calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02407",
    "question": "What is associated with Shortened outer dynein arms?",
    "seeds": [
      "Shortened outer dynein arms"
    ],
    "gold_answer": "Dynein arm defect of respiratory motile cilia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02408",
    "question": "What is associated with Symbrachydactyly of hands and feet?",
    "seeds": [
      "Symbrachydactyly of hands and feet"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02409",
    "question": "What is associated with Abnormal retinal pigmentation?",
    "seeds": [
      "Abnormal retinal pigmentation"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02410",
    "question": "What is associated with Complete cleft hard palate?",
    "seeds": [
      "Complete cleft hard palate"
    ],
    "gold_answer": "Cleft hard palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02411",
    "question": "What is associated with Prolonged N1 sleep?",
    "seeds": [
      "Prolonged N1 sleep"
    ],
    "gold_answer": "Abnormal sleep architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02412",
    "question": "What is associated with Spermatogenic failure 11?",
    "seeds": [
      "Spermatogenic failure 11"
    ],
    "gold_answer": "Abnormal spermatogenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02413",
    "question": "What is associated with Bleeding disorder, platelet-type, 20?",
    "seeds": [
      "Bleeding disorder, platelet-type, 20"
    ],
    "gold_answer": "Abnormal platelet count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02414",
    "question": "What is associated with Pigmented micronodular adrenocortical disease?",
    "seeds": [
      "Pigmented micronodular adrenocortical disease"
    ],
    "gold_answer": "Abnormal endocrine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02415",
    "question": "What is associated with Hypothyroidism due to TSH receptor mutations?",
    "seeds": [
      "Hypothyroidism due to TSH receptor mutations"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02416",
    "question": "What is associated with Prolonged PR interval?",
    "seeds": [
      "Prolonged PR interval"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02417",
    "question": "What is associated with Transient decreased circulating total IgG?",
    "seeds": [
      "Transient decreased circulating total IgG"
    ],
    "gold_answer": "Decreased circulating IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02418",
    "question": "What is associated with Abnormal trapezium morphology?",
    "seeds": [
      "Abnormal trapezium morphology"
    ],
    "gold_answer": "Abnormal carpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02419",
    "question": "What is associated with Exaggerated startle response?",
    "seeds": [
      "Exaggerated startle response"
    ],
    "gold_answer": "Abnormality of extrapyramidal motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02420",
    "question": "What is associated with Cenani-Lenz syndactyly syndrome?",
    "seeds": [
      "Cenani-Lenz syndactyly syndrome"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02421",
    "question": "What is associated with Increased anti-plant based food allergen IgE antibody level?",
    "seeds": [
      "Increased anti-plant based food allergen IgE antibody level"
    ],
    "gold_answer": "Increased anti-food allergen IgE antibody level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02422",
    "question": "What is associated with Dot-and-blot retinal hemorrhage?",
    "seeds": [
      "Dot-and-blot retinal hemorrhage"
    ],
    "gold_answer": "Intraretinal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02423",
    "question": "What is associated with Oocyte/zygote/embryo maturation arrest 20?",
    "seeds": [
      "Oocyte/zygote/embryo maturation arrest 20"
    ],
    "gold_answer": "Abnormality of the menstrual cycle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02424",
    "question": "What is associated with Finger pain?",
    "seeds": [
      "Finger pain"
    ],
    "gold_answer": "Upper limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02425",
    "question": "What is associated with Hearing loss-familial salivary gland insensitivity to aldosterone syndrome?",
    "seeds": [
      "Hearing loss-familial salivary gland insensitivity to aldosterone syndrome"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02426",
    "question": "What is associated with Focal motor seizure?",
    "seeds": [
      "Focal motor seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02427",
    "question": "What is associated with Elevated fecal pH?",
    "seeds": [
      "Elevated fecal pH"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02428",
    "question": "What is associated with Pathologic fracture?",
    "seeds": [
      "Pathologic fracture"
    ],
    "gold_answer": "Increased susceptibility to fractures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02429",
    "question": "What is associated with Abnormal mitochondrial shape?",
    "seeds": [
      "Abnormal mitochondrial shape"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02430",
    "question": "What phenotype is associated with Diarrhea 15, congenital?",
    "seeds": [
      "Diarrhea 15, congenital"
    ],
    "gold_answer": "Diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02431",
    "question": "What phenotype is associated with COG5-CDG?",
    "seeds": [
      "COG5-CDG"
    ],
    "gold_answer": "Brain imaging abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02432",
    "question": "What is associated with Tetrasomy 15q26?",
    "seeds": [
      "Tetrasomy 15q26"
    ],
    "gold_answer": "Micrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02433",
    "question": "What is associated with Deafness, neurosensory, autosomal recessive 46?",
    "seeds": [
      "Deafness, neurosensory, autosomal recessive 46"
    ],
    "gold_answer": "Profound hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02434",
    "question": "What is associated with Increased globoside Gb3 level?",
    "seeds": [
      "Increased globoside Gb3 level"
    ],
    "gold_answer": "Abnormality of glycolipid metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02435",
    "question": "What is associated with Multiple exostoses with spastic tetraparesis?",
    "seeds": [
      "Multiple exostoses with spastic tetraparesis"
    ],
    "gold_answer": "Tetraparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02436",
    "question": "What is associated with Abnormal cognitive process?",
    "seeds": [
      "Abnormal cognitive process"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02437",
    "question": "What is associated with Calciphylaxis?",
    "seeds": [
      "Calciphylaxis"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02438",
    "question": "What is associated with Elevated residual volume?",
    "seeds": [
      "Elevated residual volume"
    ],
    "gold_answer": "Abnormal residual volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02439",
    "question": "What is associated with Infection following live vaccination?",
    "seeds": [
      "Infection following live vaccination"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02440",
    "question": "What phenotype is associated with Chronic granulomatous disease 2, autosomal recessive?",
    "seeds": [
      "Chronic granulomatous disease 2, autosomal recessive"
    ],
    "gold_answer": "Inflammation of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02441",
    "question": "What is associated with Auricular pit?",
    "seeds": [
      "Auricular pit"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02442",
    "question": "What is associated with Peritonitis?",
    "seeds": [
      "Peritonitis"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02443",
    "question": "What is associated with Thickened Descemet membrane?",
    "seeds": [
      "Thickened Descemet membrane"
    ],
    "gold_answer": "Abnormal Descemet membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02444",
    "question": "What phenotype is associated with Pituitary deficiency due to Rathke cleft cysts?",
    "seeds": [
      "Pituitary deficiency due to Rathke cleft cysts"
    ],
    "gold_answer": "Increased intracranial pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02445",
    "question": "What is associated with Herniation of intervertebral nuclei?",
    "seeds": [
      "Herniation of intervertebral nuclei"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02446",
    "question": "What phenotype is associated with Retinitis pigmentosa 24?",
    "seeds": [
      "Retinitis pigmentosa 24"
    ],
    "gold_answer": "Rod-cone dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02447",
    "question": "What is associated with Retinitis pigmentosa 93?",
    "seeds": [
      "Retinitis pigmentosa 93"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02448",
    "question": "What is associated with Abnormal external ear cartilage morphology?",
    "seeds": [
      "Abnormal external ear cartilage morphology"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02449",
    "question": "What is associated with Familial generalized lentiginosis?",
    "seeds": [
      "Familial generalized lentiginosis"
    ],
    "gold_answer": "SASH1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02450",
    "question": "What is associated with Abnormal amplitude of dark-adapted dim flash electroretinogram?",
    "seeds": [
      "Abnormal amplitude of dark-adapted dim flash electroretinogram"
    ],
    "gold_answer": "Abnormal dark-adapted dim flash electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02451",
    "question": "What phenotype is associated with Surfactant metabolism dysfunction, pulmonary, 1?",
    "seeds": [
      "Surfactant metabolism dysfunction, pulmonary, 1"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02452",
    "question": "What is associated with Usher syndrome, type IE?",
    "seeds": [
      "Usher syndrome, type IE"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02453",
    "question": "What phenotype is associated with Carvajal syndrome?",
    "seeds": [
      "Carvajal syndrome"
    ],
    "gold_answer": "Sparse body hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02454",
    "question": "What is associated with ST segment elevation?",
    "seeds": [
      "ST segment elevation"
    ],
    "gold_answer": "Abnormal ST segment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02455",
    "question": "What is associated with Widow's peak?",
    "seeds": [
      "Widow's peak"
    ],
    "gold_answer": "High anterior hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02456",
    "question": "What is associated with Crowded maxillary incisors?",
    "seeds": [
      "Crowded maxillary incisors"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02457",
    "question": "What is associated with Abnormal circulating tryptophan concentration?",
    "seeds": [
      "Abnormal circulating tryptophan concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02458",
    "question": "What is associated with Insect allergy?",
    "seeds": [
      "Insect allergy"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02459",
    "question": "What is associated with Elevated urinary catecholamine level?",
    "seeds": [
      "Elevated urinary catecholamine level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02460",
    "question": "What is associated with Patchy sclerosis of the distal phalanx of the 5th toe?",
    "seeds": [
      "Patchy sclerosis of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Sclerosis of distal phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02461",
    "question": "What is associated with Polycystic ovary syndrome 1?",
    "seeds": [
      "Polycystic ovary syndrome 1"
    ],
    "gold_answer": "Enlarged ovaries",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02462",
    "question": "What is associated with Glycogen storage disease due to glucose-6-phosphatase deficiency?",
    "seeds": [
      "Glycogen storage disease due to glucose-6-phosphatase deficiency"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02463",
    "question": "What is associated with Riddle syndrome?",
    "seeds": [
      "Riddle syndrome"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02464",
    "question": "What is associated with Decreased size of nerve terminals?",
    "seeds": [
      "Decreased size of nerve terminals"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02465",
    "question": "What is associated with Branchial anomaly?",
    "seeds": [
      "Branchial anomaly"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02466",
    "question": "What is associated with Irregular epiphysis of the 1st metacarpal?",
    "seeds": [
      "Irregular epiphysis of the 1st metacarpal"
    ],
    "gold_answer": "Irregular epiphyses of the proximal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02467",
    "question": "What is associated with Bracket epiphyses of the 4th toe?",
    "seeds": [
      "Bracket epiphyses of the 4th toe"
    ],
    "gold_answer": "Bracket epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02468",
    "question": "What is associated with 22q11.2 deletion syndrome?",
    "seeds": [
      "22q11.2 deletion syndrome"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02469",
    "question": "What is associated with Perifissural pulmonary nodule?",
    "seeds": [
      "Perifissural pulmonary nodule"
    ],
    "gold_answer": "Pulmonary nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02470",
    "question": "What is associated with Premature ovarian failure 19?",
    "seeds": [
      "Premature ovarian failure 19"
    ],
    "gold_answer": "Abnormal female reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02471",
    "question": "What is associated with Stickler syndrome, type II?",
    "seeds": [
      "Stickler syndrome, type II"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02472",
    "question": "What is associated with Cerebral arteriovenous malformation?",
    "seeds": [
      "Cerebral arteriovenous malformation"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02473",
    "question": "What is associated with Pulmonary Langerhans cell histiocytosis?",
    "seeds": [
      "Pulmonary Langerhans cell histiocytosis"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02474",
    "question": "What phenotype is associated with Severe intellectual disability-epilepsy-anal anomalies-distal phalangeal hypoplasia?",
    "seeds": [
      "Severe intellectual disability-epilepsy-anal anomalies-distal phalangeal hypoplasia"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02475",
    "question": "What is associated with Abnormality of the epiphysis of the distal phalanx of the hallux?",
    "seeds": [
      "Abnormality of the epiphysis of the distal phalanx of the hallux"
    ],
    "gold_answer": "Abnormality of the epiphyses of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02476",
    "question": "What is associated with Tethered cord?",
    "seeds": [
      "Tethered cord"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02477",
    "question": "What phenotype is associated with Immunodeficiency 40?",
    "seeds": [
      "Immunodeficiency 40"
    ],
    "gold_answer": "Dyspareunia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02478",
    "question": "What is associated with Isolated sedoheptulokinase deficiency?",
    "seeds": [
      "Isolated sedoheptulokinase deficiency"
    ],
    "gold_answer": "Fat malabsorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02479",
    "question": "What is associated with Neonatal multifocal clonic seizure?",
    "seeds": [
      "Neonatal multifocal clonic seizure"
    ],
    "gold_answer": "Neonatal electro-clinical seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02480",
    "question": "What is associated with Parotid adenoma?",
    "seeds": [
      "Parotid adenoma"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02481",
    "question": "What is associated with Exacerbated by pregnancy?",
    "seeds": [
      "Exacerbated by pregnancy"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02482",
    "question": "What phenotype is associated with Resistance to thyrotropin-releasing hormone syndrome?",
    "seeds": [
      "Resistance to thyrotropin-releasing hormone syndrome"
    ],
    "gold_answer": "Maternal autoimmune disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02483",
    "question": "What is associated with Anti-La/SS-B antibody positivity?",
    "seeds": [
      "Anti-La/SS-B antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02484",
    "question": "What is associated with Metaphyseal chondrodysplasia, Jansen type?",
    "seeds": [
      "Metaphyseal chondrodysplasia, Jansen type"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02485",
    "question": "What is associated with Pyknotic bone marrow neutrophils?",
    "seeds": [
      "Pyknotic bone marrow neutrophils"
    ],
    "gold_answer": "Abnormal granulocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02486",
    "question": "What is associated with Heart block?",
    "seeds": [
      "Heart block"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02487",
    "question": "What is associated with Elevated circulating dodecanoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating dodecanoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02488",
    "question": "What phenotype is associated with Ocular anomalies-axonal neuropathy-developmental delay syndrome?",
    "seeds": [
      "Ocular anomalies-axonal neuropathy-developmental delay syndrome"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02489",
    "question": "What is associated with TNP03-related limb-girdle muscular dystrophy D2?",
    "seeds": [
      "TNP03-related limb-girdle muscular dystrophy D2"
    ],
    "gold_answer": "TNPO3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02490",
    "question": "What is associated with Thoracolumbar scoliosis?",
    "seeds": [
      "Thoracolumbar scoliosis"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02491",
    "question": "What is associated with Irregular lymph-node lymphocyte nuclei?",
    "seeds": [
      "Irregular lymph-node lymphocyte nuclei"
    ],
    "gold_answer": "Abnormal lymph-node cellular finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02492",
    "question": "What is associated with Positive peritoneal fluid bacterial culture?",
    "seeds": [
      "Positive peritoneal fluid bacterial culture"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02493",
    "question": "What phenotype is associated with Electroencephalographic peculiarity: 14 and 6 per sec. positive spikephenomenon?",
    "seeds": [
      "Electroencephalographic peculiarity: 14 and 6 per sec. positive spikephenomenon"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02494",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked, syndromic, with pigmentary mosaicism and coarse facies?",
    "seeds": [
      "Intellectual developmental disorder, X-linked, syndromic, with pigmentary mosaicism and coarse facies"
    ],
    "gold_answer": "Ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02495",
    "question": "What phenotype is associated with Hereditary sensory and autonomic neuropathy type 1?",
    "seeds": [
      "Hereditary sensory and autonomic neuropathy type 1"
    ],
    "gold_answer": "Distal amyotrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02496",
    "question": "What phenotype is associated with Osteogenesis imperfecta, type III?",
    "seeds": [
      "Osteogenesis imperfecta, type III"
    ],
    "gold_answer": "Bowing of limbs due to multiple fractures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02497",
    "question": "What phenotype is associated with Short stature, developmental delay, and congenital heart defects?",
    "seeds": [
      "Short stature, developmental delay, and congenital heart defects"
    ],
    "gold_answer": "Absent speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02498",
    "question": "What is associated with Wide epiphyses of the upper limbs?",
    "seeds": [
      "Wide epiphyses of the upper limbs"
    ],
    "gold_answer": "Enlarged epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02499",
    "question": "What is associated with Elevated residual volume?",
    "seeds": [
      "Elevated residual volume"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02500",
    "question": "What is associated with Seminal vesicle agenesis?",
    "seeds": [
      "Seminal vesicle agenesis"
    ],
    "gold_answer": "Abnormal male internal genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02501",
    "question": "What is associated with Sick sinus syndrome?",
    "seeds": [
      "Sick sinus syndrome"
    ],
    "gold_answer": "Heart block",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02502",
    "question": "What is associated with Abnormal circulating aldolase concentration?",
    "seeds": [
      "Abnormal circulating aldolase concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02503",
    "question": "What phenotype is associated with Immunodeficiency, common variable, 7?",
    "seeds": [
      "Immunodeficiency, common variable, 7"
    ],
    "gold_answer": "Decreased circulating total IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02504",
    "question": "What is associated with Abnormal spinocerebellar tract morphology?",
    "seeds": [
      "Abnormal spinocerebellar tract morphology"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02505",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2N?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2N"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02506",
    "question": "What is associated with Vitamin B12-unresponsive methylmalonic acidemia type mut0?",
    "seeds": [
      "Vitamin B12-unresponsive methylmalonic acidemia type mut0"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02507",
    "question": "What is associated with Sleep-related hypermotor epilepsy?",
    "seeds": [
      "Sleep-related hypermotor epilepsy"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02508",
    "question": "What is associated with Small yellow/white macular lesion?",
    "seeds": [
      "Small yellow/white macular lesion"
    ],
    "gold_answer": "Yellow/white macular lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02509",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 5?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 5"
    ],
    "gold_answer": "Abnormal cortical gyration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02510",
    "question": "What phenotype is associated with Immunodeficiency, common variable, 12?",
    "seeds": [
      "Immunodeficiency, common variable, 12"
    ],
    "gold_answer": "Atrophic gastritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02511",
    "question": "What is associated with Decreased 3-hydroxyisobutyrate dehydrogenase activity?",
    "seeds": [
      "Decreased 3-hydroxyisobutyrate dehydrogenase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02512",
    "question": "What is associated with Decreased methylmalonyl-CoA mutase activity?",
    "seeds": [
      "Decreased methylmalonyl-CoA mutase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02513",
    "question": "What is associated with Elbow fracture?",
    "seeds": [
      "Elbow fracture"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02514",
    "question": "What is associated with Decreased circulating complement C4 concentration?",
    "seeds": [
      "Decreased circulating complement C4 concentration"
    ],
    "gold_answer": "Reduced circulating complement concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02515",
    "question": "What is associated with Aplasia/Hypoplasia affecting the eye?",
    "seeds": [
      "Aplasia/Hypoplasia affecting the eye"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02516",
    "question": "What is associated with Chorangioma?",
    "seeds": [
      "Chorangioma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02517",
    "question": "What is associated with Coiled sperm flagella?",
    "seeds": [
      "Coiled sperm flagella"
    ],
    "gold_answer": "Abnormal sperm tail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02518",
    "question": "What phenotype is associated with Adamantinoma?",
    "seeds": [
      "Adamantinoma"
    ],
    "gold_answer": "Bone pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02519",
    "question": "What is associated with Anger?",
    "seeds": [
      "Anger"
    ],
    "gold_answer": "Abnormal emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02520",
    "question": "What is associated with Progressive spastic paraparesis?",
    "seeds": [
      "Progressive spastic paraparesis"
    ],
    "gold_answer": "Lower limb spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02521",
    "question": "What is associated with Fractured rib?",
    "seeds": [
      "Fractured rib"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02522",
    "question": "What is associated with Monochromacy?",
    "seeds": [
      "Monochromacy"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02523",
    "question": "What is associated with Sacral meningocele?",
    "seeds": [
      "Sacral meningocele"
    ],
    "gold_answer": "Abnormal sacrum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02524",
    "question": "What is associated with Bracket epiphyses of the distal phalanges of the hand?",
    "seeds": [
      "Bracket epiphyses of the distal phalanges of the hand"
    ],
    "gold_answer": "Abnormal distal phalanx morphology of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02525",
    "question": "What is associated with Leukemia, chronic lymphocytic?",
    "seeds": [
      "Leukemia, chronic lymphocytic"
    ],
    "gold_answer": "Immunodeficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02526",
    "question": "What is associated with Osteogenesis imperfecta-retinopathy-seizures-intellectual disability syndrome?",
    "seeds": [
      "Osteogenesis imperfecta-retinopathy-seizures-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02527",
    "question": "What is associated with Cartilage destruction?",
    "seeds": [
      "Cartilage destruction"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02528",
    "question": "What is associated with Glomerular capillary wall duplication without cellular interposition?",
    "seeds": [
      "Glomerular capillary wall duplication without cellular interposition"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02529",
    "question": "What is associated with Anti-SEZ6L2 antibody?",
    "seeds": [
      "Anti-SEZ6L2 antibody"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02530",
    "question": "What is associated with Developmental and epileptic encephalopathy 112?",
    "seeds": [
      "Developmental and epileptic encephalopathy 112"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02531",
    "question": "What is associated with ACERULOPLASMINEMIA?",
    "seeds": [
      "ACERULOPLASMINEMIA"
    ],
    "gold_answer": "Abnormal basal ganglia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02532",
    "question": "What is associated with Ataxia with myoclonic epilepsy and presenile dementia?",
    "seeds": [
      "Ataxia with myoclonic epilepsy and presenile dementia"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02533",
    "question": "What is associated with Neoplasm of the middle ear?",
    "seeds": [
      "Neoplasm of the middle ear"
    ],
    "gold_answer": "Abnormality of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02534",
    "question": "What is associated with Cortical radial artery intima/media arteriosclerosis?",
    "seeds": [
      "Cortical radial artery intima/media arteriosclerosis"
    ],
    "gold_answer": "Abnormal cortical radial artery intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02535",
    "question": "What is associated with Severe intellectual disability?",
    "seeds": [
      "Severe intellectual disability"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02536",
    "question": "What is associated with Unilateral facial palsy?",
    "seeds": [
      "Unilateral facial palsy"
    ],
    "gold_answer": "Facial palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02537",
    "question": "What phenotype is associated with Hallux varus-preaxial polysyndactyly syndrome?",
    "seeds": [
      "Hallux varus-preaxial polysyndactyly syndrome"
    ],
    "gold_answer": "Sandal gap",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02538",
    "question": "What is associated with Increased level of gamma-aminobutyric acid in urine?",
    "seeds": [
      "Increased level of gamma-aminobutyric acid in urine"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02539",
    "question": "What is associated with Impaired memory B cell generation?",
    "seeds": [
      "Impaired memory B cell generation"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02540",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 31?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 31"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02541",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type Ii?",
    "seeds": [
      "Congenital disorder of glycosylation, type Ii"
    ],
    "gold_answer": "Focal T2 hyperintense basal ganglia lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02542",
    "question": "What is associated with Minicore myopathy with external ophthalmoplegia?",
    "seeds": [
      "Minicore myopathy with external ophthalmoplegia"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02543",
    "question": "What is associated with Placenta accreta?",
    "seeds": [
      "Placenta accreta"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02544",
    "question": "What is associated with Dysequilibrium syndrome?",
    "seeds": [
      "Dysequilibrium syndrome"
    ],
    "gold_answer": "ATP8A2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02545",
    "question": "What is associated with Aphonia-deafness-retinal dystrophy-bifid halluces-intellectual disability syndrome?",
    "seeds": [
      "Aphonia-deafness-retinal dystrophy-bifid halluces-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02546",
    "question": "What is associated with Abnormal macroscopic urine appearance?",
    "seeds": [
      "Abnormal macroscopic urine appearance"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02547",
    "question": "What phenotype is associated with Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency?",
    "seeds": [
      "Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency"
    ],
    "gold_answer": "Polyneuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02548",
    "question": "What is associated with Fallopian tube mass?",
    "seeds": [
      "Fallopian tube mass"
    ],
    "gold_answer": "Abnormal fallopian tube morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02549",
    "question": "What is associated with Acne inversa, familial, 2, with or without dowling-degos disease?",
    "seeds": [
      "Acne inversa, familial, 2, with or without dowling-degos disease"
    ],
    "gold_answer": "Cutaneous abscess",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02550",
    "question": "What is associated with Trigonocephaly 1?",
    "seeds": [
      "Trigonocephaly 1"
    ],
    "gold_answer": "Facial hypertrichosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02551",
    "question": "What is associated with Supracardiac total anomalous pulmonary venous connection?",
    "seeds": [
      "Supracardiac total anomalous pulmonary venous connection"
    ],
    "gold_answer": "Abnormal pulmonary vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02552",
    "question": "What phenotype is associated with Megalencephalic leukoencephalopathy with subcortical cysts 2A?",
    "seeds": [
      "Megalencephalic leukoencephalopathy with subcortical cysts 2A"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02553",
    "question": "What is associated with Curved hallux phalanx?",
    "seeds": [
      "Curved hallux phalanx"
    ],
    "gold_answer": "Abnormal hallux phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02554",
    "question": "What is associated with Parkinson disease 19a, juvenile-onset?",
    "seeds": [
      "Parkinson disease 19a, juvenile-onset"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02555",
    "question": "What is associated with N syndrome?",
    "seeds": [
      "N syndrome"
    ],
    "gold_answer": "Abnormality of the urethra",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02556",
    "question": "What is associated with Abnormal middle ear morphology?",
    "seeds": [
      "Abnormal middle ear morphology"
    ],
    "gold_answer": "Abnormality of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02557",
    "question": "What is associated with Dystonia 26, myoclonic?",
    "seeds": [
      "Dystonia 26, myoclonic"
    ],
    "gold_answer": "Abnormal eyelid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02558",
    "question": "What is associated with Bulbar palsy?",
    "seeds": [
      "Bulbar palsy"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02559",
    "question": "What is associated with Elevated circulating reverse T3 concentration?",
    "seeds": [
      "Elevated circulating reverse T3 concentration"
    ],
    "gold_answer": "Abnormal circulating thyroid hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02560",
    "question": "What is associated with Knee extension contracture?",
    "seeds": [
      "Knee extension contracture"
    ],
    "gold_answer": "Abnormal knee morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02561",
    "question": "What is associated with Decreased body fat percentage?",
    "seeds": [
      "Decreased body fat percentage"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02562",
    "question": "What is associated with Broad toe?",
    "seeds": [
      "Broad toe"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02563",
    "question": "What is associated with Otitis externa?",
    "seeds": [
      "Otitis externa"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02564",
    "question": "What is associated with Exudative vitreoretinopathy 5?",
    "seeds": [
      "Exudative vitreoretinopathy 5"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02565",
    "question": "What is associated with Decreased circulating IgG subclass concentration?",
    "seeds": [
      "Decreased circulating IgG subclass concentration"
    ],
    "gold_answer": "Decreased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02566",
    "question": "What is associated with Immunodeficiency 112?",
    "seeds": [
      "Immunodeficiency 112"
    ],
    "gold_answer": "Abnormal total T cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02567",
    "question": "What phenotype is associated with Cystic fibrosis, modifier of, 1?",
    "seeds": [
      "Cystic fibrosis, modifier of, 1"
    ],
    "gold_answer": "Chronic diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02568",
    "question": "What is associated with Fragmentation of the epiphyses of the 2nd toe?",
    "seeds": [
      "Fragmentation of the epiphyses of the 2nd toe"
    ],
    "gold_answer": "Fragmentation of the epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02569",
    "question": "What is associated with Thought broadcasting?",
    "seeds": [
      "Thought broadcasting"
    ],
    "gold_answer": "Disorder of thought control",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02570",
    "question": "What phenotype is associated with Alveolar echinococcosis?",
    "seeds": [
      "Alveolar echinococcosis"
    ],
    "gold_answer": "Bipedal edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02571",
    "question": "What is associated with Frontonasal dysplasia 3?",
    "seeds": [
      "Frontonasal dysplasia 3"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02572",
    "question": "What is associated with Myofibrillar myopathy 10?",
    "seeds": [
      "Myofibrillar myopathy 10"
    ],
    "gold_answer": "Exercise intolerance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02573",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 80?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 80"
    ],
    "gold_answer": "UBAP1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02574",
    "question": "What is associated with Triggered by fasting?",
    "seeds": [
      "Triggered by fasting"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02575",
    "question": "What is associated with Ciliary dyskinesia, primary, 46?",
    "seeds": [
      "Ciliary dyskinesia, primary, 46"
    ],
    "gold_answer": "Abnormal bronchus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02576",
    "question": "What is associated with Agenesis of mandibular premolar?",
    "seeds": [
      "Agenesis of mandibular premolar"
    ],
    "gold_answer": "Abnormality of premolar",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02577",
    "question": "What is associated with Scalp nodule?",
    "seeds": [
      "Scalp nodule"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02578",
    "question": "What phenotype is associated with Deafness, neurosensory, autosomal recessive 3?",
    "seeds": [
      "Deafness, neurosensory, autosomal recessive 3"
    ],
    "gold_answer": "Profound sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02579",
    "question": "What is associated with Melanoma, cutaneous malignant, susceptibility to, 3?",
    "seeds": [
      "Melanoma, cutaneous malignant, susceptibility to, 3"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02580",
    "question": "What phenotype is associated with MPI-CDG?",
    "seeds": [
      "MPI-CDG"
    ],
    "gold_answer": "Diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02581",
    "question": "What phenotype is associated with Alstrom syndrome?",
    "seeds": [
      "Alstrom syndrome"
    ],
    "gold_answer": "Hyperostosis frontalis interna",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02582",
    "question": "What is associated with Disproportionate tall stature?",
    "seeds": [
      "Disproportionate tall stature"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02583",
    "question": "What phenotype is associated with Hemolytic anemia due to red cell pyruvate kinase deficiency?",
    "seeds": [
      "Hemolytic anemia due to red cell pyruvate kinase deficiency"
    ],
    "gold_answer": "Small for gestational age",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02584",
    "question": "What is associated with Lack of germinal center mitotic figures?",
    "seeds": [
      "Lack of germinal center mitotic figures"
    ],
    "gold_answer": "Abnormal lymph-node follicle architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02585",
    "question": "What is associated with CSF pleocytosis?",
    "seeds": [
      "CSF pleocytosis"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02586",
    "question": "What is associated with Posterior column ataxia?",
    "seeds": [
      "Posterior column ataxia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02587",
    "question": "What is associated with Abnormal tubular basement membrane morphology?",
    "seeds": [
      "Abnormal tubular basement membrane morphology"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02588",
    "question": "What is associated with Triceps areflexia?",
    "seeds": [
      "Triceps areflexia"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02589",
    "question": "What phenotype is associated with Mayer-Rokitansky-Kuster-Hauser syndrome?",
    "seeds": [
      "Mayer-Rokitansky-Kuster-Hauser syndrome"
    ],
    "gold_answer": "Renal cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02590",
    "question": "What is associated with Adducted thumb?",
    "seeds": [
      "Adducted thumb"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02591",
    "question": "What is associated with Hypocalcemic vitamin D-dependent rickets?",
    "seeds": [
      "Hypocalcemic vitamin D-dependent rickets"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02592",
    "question": "What is associated with Nephropathy?",
    "seeds": [
      "Nephropathy"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02593",
    "question": "What is associated with Periosteal thickening of long tubular bones?",
    "seeds": [
      "Periosteal thickening of long tubular bones"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02594",
    "question": "What is associated with Intrahepatic bile duct cysts?",
    "seeds": [
      "Intrahepatic bile duct cysts"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02595",
    "question": "What is associated with Internal carotid artery dissection?",
    "seeds": [
      "Internal carotid artery dissection"
    ],
    "gold_answer": "Abnormal carotid artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02596",
    "question": "What is associated with Pelvic girdle muscle weakness?",
    "seeds": [
      "Pelvic girdle muscle weakness"
    ],
    "gold_answer": "Limb-girdle muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02597",
    "question": "What is associated with Ackerman syndrome?",
    "seeds": [
      "Ackerman syndrome"
    ],
    "gold_answer": "Abnormal dental root morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02598",
    "question": "What is associated with Extension of hair growth on temples to lateral eyebrow?",
    "seeds": [
      "Extension of hair growth on temples to lateral eyebrow"
    ],
    "gold_answer": "Abnormality of the frontal hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02599",
    "question": "What is associated with Early-onset parkinsonism-intellectual disability syndrome?",
    "seeds": [
      "Early-onset parkinsonism-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02600",
    "question": "What is associated with Tangential speech?",
    "seeds": [
      "Tangential speech"
    ],
    "gold_answer": "Abnormal lexical patterns",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02601",
    "question": "What phenotype is associated with Amelogenesis imperfecta, type IIIC?",
    "seeds": [
      "Amelogenesis imperfecta, type IIIC"
    ],
    "gold_answer": "Anterior open-bite malocclusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02602",
    "question": "What is associated with Brachydactyly, type A6?",
    "seeds": [
      "Brachydactyly, type A6"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02603",
    "question": "What is associated with Isolated absence/hypoplasia of fingers excluding thumb, unilateral?",
    "seeds": [
      "Isolated absence/hypoplasia of fingers excluding thumb, unilateral"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02604",
    "question": "What is associated with Pseudohypoaldosteronism, type IIB?",
    "seeds": [
      "Pseudohypoaldosteronism, type IIB"
    ],
    "gold_answer": "Hyperchloremic acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02605",
    "question": "What is associated with Langerhans cell histiocytosis?",
    "seeds": [
      "Langerhans cell histiocytosis"
    ],
    "gold_answer": "NRAS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02606",
    "question": "What is associated with Increased urinary glycerol?",
    "seeds": [
      "Increased urinary glycerol"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02607",
    "question": "What is associated with Interatrial communication?",
    "seeds": [
      "Interatrial communication"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02608",
    "question": "What is associated with Elevated circulating beta-glucuronidase activity?",
    "seeds": [
      "Elevated circulating beta-glucuronidase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02609",
    "question": "What is associated with Silica dust exposure?",
    "seeds": [
      "Silica dust exposure"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02610",
    "question": "What is associated with F12-related hereditary angioedema with normal C1Inh?",
    "seeds": [
      "F12-related hereditary angioedema with normal C1Inh"
    ],
    "gold_answer": "F12",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_train_02611",
    "question": "What is associated with Elevated CSF dihydrouracil concentration?",
    "seeds": [
      "Elevated CSF dihydrouracil concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02612",
    "question": "What is associated with Curved thumb phalanx?",
    "seeds": [
      "Curved thumb phalanx"
    ],
    "gold_answer": "Curved fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02613",
    "question": "What is associated with Focal segmental glomerulosclerosis 8?",
    "seeds": [
      "Focal segmental glomerulosclerosis 8"
    ],
    "gold_answer": "Chronic kidney disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02614",
    "question": "What is associated with T-wave inversion?",
    "seeds": [
      "T-wave inversion"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02615",
    "question": "What is associated with Non-convulsive status epilepticus with coma?",
    "seeds": [
      "Non-convulsive status epilepticus with coma"
    ],
    "gold_answer": "Status epilepticus without prominent motor symptoms",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02616",
    "question": "What is associated with Foveoschisis?",
    "seeds": [
      "Foveoschisis"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02617",
    "question": "What is associated with Abnormal male germ cell morphology?",
    "seeds": [
      "Abnormal male germ cell morphology"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02618",
    "question": "What is associated with Osteoarthritis of the elbow?",
    "seeds": [
      "Osteoarthritis of the elbow"
    ],
    "gold_answer": "Abnormality of upper limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02619",
    "question": "What is associated with Factor VIII deficiency?",
    "seeds": [
      "Factor VIII deficiency"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02620",
    "question": "What is associated with Alacrima, achalasia, and impaired intellectual development syndrome?",
    "seeds": [
      "Alacrima, achalasia, and impaired intellectual development syndrome"
    ],
    "gold_answer": "Abnormal upper lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02621",
    "question": "What is associated with Abnormality of body weight?",
    "seeds": [
      "Abnormality of body weight"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02622",
    "question": "What is associated with Adenocarcinoma of the colon?",
    "seeds": [
      "Adenocarcinoma of the colon"
    ],
    "gold_answer": "Adenocarcinoma of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02623",
    "question": "What is associated with Abnormal circulating hepcidin concentration?",
    "seeds": [
      "Abnormal circulating hepcidin concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02624",
    "question": "What is associated with Migraine with or without aura, susceptibility to, 1?",
    "seeds": [
      "Migraine with or without aura, susceptibility to, 1"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02625",
    "question": "What is associated with Oculomotor nerve palsy?",
    "seeds": [
      "Oculomotor nerve palsy"
    ],
    "gold_answer": "Ophthalmoparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02626",
    "question": "What is associated with Nervous tissue neoplasm?",
    "seeds": [
      "Nervous tissue neoplasm"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02627",
    "question": "What is associated with Autoimmune polyendocrine syndrome, type II?",
    "seeds": [
      "Autoimmune polyendocrine syndrome, type II"
    ],
    "gold_answer": "TNFAIP3",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_02628",
    "question": "What is associated with Combined immunodeficiency due to ZAP70 deficiency?",
    "seeds": [
      "Combined immunodeficiency due to ZAP70 deficiency"
    ],
    "gold_answer": "Opportunistic infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02629",
    "question": "What is associated with Enlarged hippocampus?",
    "seeds": [
      "Enlarged hippocampus"
    ],
    "gold_answer": "Abnormal hippocampus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02630",
    "question": "What is associated with Left posterior fascicular block?",
    "seeds": [
      "Left posterior fascicular block"
    ],
    "gold_answer": "Heart block",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02631",
    "question": "What phenotype is associated with Pruritus, hereditary localized?",
    "seeds": [
      "Pruritus, hereditary localized"
    ],
    "gold_answer": "Pruritus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02632",
    "question": "What is associated with Proteasome-associated autoinflammatory syndrome 5?",
    "seeds": [
      "Proteasome-associated autoinflammatory syndrome 5"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02633",
    "question": "What is associated with Lung fibroma?",
    "seeds": [
      "Lung fibroma"
    ],
    "gold_answer": "Neoplasm of the lung",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02634",
    "question": "What is associated with FINGERS, RELATIVE LENGTH OF?",
    "seeds": [
      "FINGERS, RELATIVE LENGTH OF"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02635",
    "question": "What is associated with Infantile choroidocerebral calcification syndrome?",
    "seeds": [
      "Infantile choroidocerebral calcification syndrome"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02636",
    "question": "What is associated with Abnormal circulating carboxylic acid concentration?",
    "seeds": [
      "Abnormal circulating carboxylic acid concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02637",
    "question": "What is associated with Polyposis, skin pigmentation, alopecia, and fingernail changes?",
    "seeds": [
      "Polyposis, skin pigmentation, alopecia, and fingernail changes"
    ],
    "gold_answer": "Malignant gastrointestinal tract tumors",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02638",
    "question": "What is associated with Focal impaired awareness sensory seizure with gustatory features?",
    "seeds": [
      "Focal impaired awareness sensory seizure with gustatory features"
    ],
    "gold_answer": "Focal sensory seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02639",
    "question": "What is associated with Increased circulating troponin T concentration?",
    "seeds": [
      "Increased circulating troponin T concentration"
    ],
    "gold_answer": "Abnormal cardiac test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02640",
    "question": "What is associated with Neoplasm of the gastrointestinal tract?",
    "seeds": [
      "Neoplasm of the gastrointestinal tract"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02641",
    "question": "What is associated with Pontocerebellar hypoplasia, type 16?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 16"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02642",
    "question": "What is associated with Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness?",
    "seeds": [
      "Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness"
    ],
    "gold_answer": "Reduced consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02643",
    "question": "What is associated with Reduced Acyl-CoA:dihydroxyacetone phosphate acyltransferase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced Acyl-CoA:dihydroxyacetone phosphate acyltransferase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal enzyme activity in cultured fibroblasts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02644",
    "question": "What is associated with Pleural cobblestoning?",
    "seeds": [
      "Pleural cobblestoning"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02645",
    "question": "What is associated with Bulbous tooth?",
    "seeds": [
      "Bulbous tooth"
    ],
    "gold_answer": "Abnormal dental morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02646",
    "question": "What is associated with Intratubular light-chain casts?",
    "seeds": [
      "Intratubular light-chain casts"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02647",
    "question": "What phenotype is associated with Multiple pterygium-malignant hyperthermia syndrome?",
    "seeds": [
      "Multiple pterygium-malignant hyperthermia syndrome"
    ],
    "gold_answer": "Exaggerated cupid's bow",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02648",
    "question": "What is associated with Epilepsia partialis continua?",
    "seeds": [
      "Epilepsia partialis continua"
    ],
    "gold_answer": "Status epilepticus with prominent motor symptoms",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02649",
    "question": "What is associated with Abnormal arm span?",
    "seeds": [
      "Abnormal arm span"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02650",
    "question": "What is associated with Limb tremor?",
    "seeds": [
      "Limb tremor"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02651",
    "question": "What is associated with Spasticity?",
    "seeds": [
      "Spasticity"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02652",
    "question": "What is associated with Abnormality of circulating fibrinogen?",
    "seeds": [
      "Abnormality of circulating fibrinogen"
    ],
    "gold_answer": "Abnormality of the common coagulation pathway",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02653",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia, X-linked, with mental deterioration?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, X-linked, with mental deterioration"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02654",
    "question": "What is associated with Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II?",
    "seeds": [
      "Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02655",
    "question": "What is associated with Abnormality of the middle phalanx of the 5th toe?",
    "seeds": [
      "Abnormality of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02656",
    "question": "What is associated with Abnormal cell proliferation?",
    "seeds": [
      "Abnormal cell proliferation"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02657",
    "question": "What is associated with Microtia?",
    "seeds": [
      "Microtia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02658",
    "question": "What is associated with Salt craving?",
    "seeds": [
      "Salt craving"
    ],
    "gold_answer": "Abnormal consumption behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02659",
    "question": "What is associated with Hypoplasia of the lower eyelids?",
    "seeds": [
      "Hypoplasia of the lower eyelids"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the eyelid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02660",
    "question": "What is associated with Patchy sclerosis of 5th toe phalanx?",
    "seeds": [
      "Patchy sclerosis of 5th toe phalanx"
    ],
    "gold_answer": "Abnormal fifth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02661",
    "question": "What is associated with Shortening of all metacarpals?",
    "seeds": [
      "Shortening of all metacarpals"
    ],
    "gold_answer": "Short metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02662",
    "question": "What phenotype is associated with Phosphoenolpyruvate carboxykinase deficiency, cytosolic?",
    "seeds": [
      "Phosphoenolpyruvate carboxykinase deficiency, cytosolic"
    ],
    "gold_answer": "Hepatic steatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02663",
    "question": "What is associated with Frontolimbic dementia?",
    "seeds": [
      "Frontolimbic dementia"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02664",
    "question": "What is associated with Binucleated visceral epithelial cells?",
    "seeds": [
      "Binucleated visceral epithelial cells"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02665",
    "question": "What is associated with ASPARTYLGLUCOSAMINURIA?",
    "seeds": [
      "ASPARTYLGLUCOSAMINURIA"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02666",
    "question": "What is associated with Asymmetric blood pressure between legs?",
    "seeds": [
      "Asymmetric blood pressure between legs"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02667",
    "question": "What is associated with Truncus arteriosus?",
    "seeds": [
      "Truncus arteriosus"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02668",
    "question": "What is associated with Feather allergy?",
    "seeds": [
      "Feather allergy"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02669",
    "question": "What is associated with Eversion of lateral third of lower eyelids?",
    "seeds": [
      "Eversion of lateral third of lower eyelids"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02670",
    "question": "What is associated with Focal impaired awareness non-motor seizure?",
    "seeds": [
      "Focal impaired awareness non-motor seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02671",
    "question": "What phenotype is associated with Diabetes mellitus, insulin-dependent, 6?",
    "seeds": [
      "Diabetes mellitus, insulin-dependent, 6"
    ],
    "gold_answer": "Diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02672",
    "question": "What phenotype is associated with Meningioma, familial, susceptibility to?",
    "seeds": [
      "Meningioma, familial, susceptibility to"
    ],
    "gold_answer": "Trigeminal neuralgia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02673",
    "question": "What is associated with Galactose intolerance?",
    "seeds": [
      "Galactose intolerance"
    ],
    "gold_answer": "Abnormal metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02674",
    "question": "What is associated with Reduced erythrocyte hexokinase activity?",
    "seeds": [
      "Reduced erythrocyte hexokinase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02675",
    "question": "What is associated with Syringomyelia, isolated?",
    "seeds": [
      "Syringomyelia, isolated"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02676",
    "question": "What is associated with EEG with photoparoxysmal response grade III?",
    "seeds": [
      "EEG with photoparoxysmal response grade III"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02677",
    "question": "What is associated with Venular insufficiency, systemic?",
    "seeds": [
      "Venular insufficiency, systemic"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02678",
    "question": "What is associated with Lethargy?",
    "seeds": [
      "Lethargy"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02679",
    "question": "What is associated with Pharyngalgia?",
    "seeds": [
      "Pharyngalgia"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02680",
    "question": "What is associated with Retinal dystrophy with leukodystrophy?",
    "seeds": [
      "Retinal dystrophy with leukodystrophy"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02681",
    "question": "What is associated with Elevated circulating apolipoprotein B concentration?",
    "seeds": [
      "Elevated circulating apolipoprotein B concentration"
    ],
    "gold_answer": "Abnormal circulating apolipoprotein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02682",
    "question": "What phenotype is associated with Focal segmental glomerulosclerosis 7?",
    "seeds": [
      "Focal segmental glomerulosclerosis 7"
    ],
    "gold_answer": "Focal segmental glomerulosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02683",
    "question": "What is associated with Congenital myopathy 21 with early respiratory failure?",
    "seeds": [
      "Congenital myopathy 21 with early respiratory failure"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02684",
    "question": "What is associated with Elevated ciculating 5-hydroxymethyluracil concentration?",
    "seeds": [
      "Elevated ciculating 5-hydroxymethyluracil concentration"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02685",
    "question": "What is associated with Positive carpal Tinel sign?",
    "seeds": [
      "Positive carpal Tinel sign"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02686",
    "question": "What is associated with Progressive distal muscular atrophy?",
    "seeds": [
      "Progressive distal muscular atrophy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02687",
    "question": "What is associated with Adrenal hypoplasia, congenital, with absent pituitary luteinizinghormone?",
    "seeds": [
      "Adrenal hypoplasia, congenital, with absent pituitary luteinizinghormone"
    ],
    "gold_answer": "Abnormal adrenal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02688",
    "question": "What is associated with Decreased immunoglobulin level in body fluid?",
    "seeds": [
      "Decreased immunoglobulin level in body fluid"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02689",
    "question": "What is associated with Exstrophy?",
    "seeds": [
      "Exstrophy"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02690",
    "question": "What phenotype is associated with C7 deficiency?",
    "seeds": [
      "C7 deficiency"
    ],
    "gold_answer": "Decreased circulating complement C7 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02691",
    "question": "What is associated with Interhemispheric cyst?",
    "seeds": [
      "Interhemispheric cyst"
    ],
    "gold_answer": "Abnormal subarachnoid space morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02692",
    "question": "What is associated with Duplication of phalanx of 2nd finger?",
    "seeds": [
      "Duplication of phalanx of 2nd finger"
    ],
    "gold_answer": "Abnormality of the phalanges of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02693",
    "question": "What phenotype is associated with Angioma serpiginosum, X-linked?",
    "seeds": [
      "Angioma serpiginosum, X-linked"
    ],
    "gold_answer": "Sparse hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02694",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 2?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 2"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02695",
    "question": "What is associated with Tendon rupture?",
    "seeds": [
      "Tendon rupture"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02696",
    "question": "What is associated with Bardet-Biedl syndrome 5?",
    "seeds": [
      "Bardet-Biedl syndrome 5"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02697",
    "question": "What is associated with Extreme axis deviation?",
    "seeds": [
      "Extreme axis deviation"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02698",
    "question": "What is associated with Agammaglobulinemia 2, autosomal recessive?",
    "seeds": [
      "Agammaglobulinemia 2, autosomal recessive"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02699",
    "question": "What is associated with Elevated circulating ghrelin concentration?",
    "seeds": [
      "Elevated circulating ghrelin concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02700",
    "question": "What is associated with Endometritis?",
    "seeds": [
      "Endometritis"
    ],
    "gold_answer": "Abnormality of the uterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02701",
    "question": "What is associated with Interictal epileptiform activity?",
    "seeds": [
      "Interictal epileptiform activity"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02702",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 9?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 9"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02703",
    "question": "What is associated with Decreased circulating epinephrine concentration?",
    "seeds": [
      "Decreased circulating epinephrine concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02704",
    "question": "What phenotype is associated with Schinzel-Giedion syndrome?",
    "seeds": [
      "Schinzel-Giedion syndrome"
    ],
    "gold_answer": "Hypsarrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02705",
    "question": "What is associated with Erythematous macule?",
    "seeds": [
      "Erythematous macule"
    ],
    "gold_answer": "Macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02706",
    "question": "What is associated with Lopes-Maciel-Rodan syndrome?",
    "seeds": [
      "Lopes-Maciel-Rodan syndrome"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02707",
    "question": "What is associated with Positive respiratory tract SARS-CoV-2 coronavirus nucleic acid test?",
    "seeds": [
      "Positive respiratory tract SARS-CoV-2 coronavirus nucleic acid test"
    ],
    "gold_answer": "Positive respiratory tract nucleic acid pathogen test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02708",
    "question": "What is associated with Rieger anomaly?",
    "seeds": [
      "Rieger anomaly"
    ],
    "gold_answer": "Hypoplasia of the iris",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02709",
    "question": "What phenotype is associated with Rudiger syndrome?",
    "seeds": [
      "Rudiger syndrome"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02710",
    "question": "What is associated with Hypoisoleucinemia?",
    "seeds": [
      "Hypoisoleucinemia"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02711",
    "question": "What is associated with Abnormal circulating interleukin 21 concentration?",
    "seeds": [
      "Abnormal circulating interleukin 21 concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02712",
    "question": "What is associated with Distal amyotrophy?",
    "seeds": [
      "Distal amyotrophy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02713",
    "question": "What is associated with Lower motor neuron syndrome with late-adult onset?",
    "seeds": [
      "Lower motor neuron syndrome with late-adult onset"
    ],
    "gold_answer": "Abnormal nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02714",
    "question": "What is associated with CHD4-related neurodevelopmental disorder?",
    "seeds": [
      "CHD4-related neurodevelopmental disorder"
    ],
    "gold_answer": "CHD4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02715",
    "question": "What is associated with Gerbode ventricular septal defect?",
    "seeds": [
      "Gerbode ventricular septal defect"
    ],
    "gold_answer": "Ventricular septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02716",
    "question": "What is associated with Widened subarachnoid space?",
    "seeds": [
      "Widened subarachnoid space"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02717",
    "question": "What is associated with Neonatal short-trunk short stature?",
    "seeds": [
      "Neonatal short-trunk short stature"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02718",
    "question": "What is associated with Alpha-gal allergy?",
    "seeds": [
      "Alpha-gal allergy"
    ],
    "gold_answer": "Immunologic hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02719",
    "question": "What phenotype is associated with 48,XXYY syndrome?",
    "seeds": [
      "48,XXYY syndrome"
    ],
    "gold_answer": "Open bite",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02720",
    "question": "What is associated with Otofaciocervical syndrome?",
    "seeds": [
      "Otofaciocervical syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02721",
    "question": "What is associated with Positive urine barbiturate test?",
    "seeds": [
      "Positive urine barbiturate test"
    ],
    "gold_answer": "Presence of xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02722",
    "question": "What is associated with Myotonia of the lower limb?",
    "seeds": [
      "Myotonia of the lower limb"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02723",
    "question": "What is associated with Fetal pyelectasis?",
    "seeds": [
      "Fetal pyelectasis"
    ],
    "gold_answer": "Fetal ultrasound soft marker",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02724",
    "question": "What is associated with Fixated interests?",
    "seeds": [
      "Fixated interests"
    ],
    "gold_answer": "Restricted or repetitive behaviors or interests",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02725",
    "question": "What is associated with Posterior communicating artery aneurysm?",
    "seeds": [
      "Posterior communicating artery aneurysm"
    ],
    "gold_answer": "Abnormal cerebral artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02726",
    "question": "What is associated with Peripheral primitive neuroectodermal neoplasm?",
    "seeds": [
      "Peripheral primitive neuroectodermal neoplasm"
    ],
    "gold_answer": "Primitive neuroectodermal tumor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02727",
    "question": "What phenotype is associated with Cutis laxa, autosomal recessive, type IIIB?",
    "seeds": [
      "Cutis laxa, autosomal recessive, type IIIB"
    ],
    "gold_answer": "Hip dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02728",
    "question": "What is associated with Growth hormone insensitivity, partial?",
    "seeds": [
      "Growth hormone insensitivity, partial"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02729",
    "question": "What is associated with Femoral artery duplication?",
    "seeds": [
      "Femoral artery duplication"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02730",
    "question": "What is associated with Aplasia of the phalanges of the toes?",
    "seeds": [
      "Aplasia of the phalanges of the toes"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02731",
    "question": "What is associated with Abnormal galactosidase enyzme activity?",
    "seeds": [
      "Abnormal galactosidase enyzme activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02732",
    "question": "What phenotype is associated with Spinocerebellar ataxia, autosomal recessive 27?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 27"
    ],
    "gold_answer": "Aggressive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02733",
    "question": "What is associated with Sacral lipoma?",
    "seeds": [
      "Sacral lipoma"
    ],
    "gold_answer": "Spinal lipoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02734",
    "question": "What is associated with Hypokalemia?",
    "seeds": [
      "Hypokalemia"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02735",
    "question": "What is associated with Torn oral frenulum?",
    "seeds": [
      "Torn oral frenulum"
    ],
    "gold_answer": "Abnormal oral frenulum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02736",
    "question": "What is associated with Papulovesicular eruption?",
    "seeds": [
      "Papulovesicular eruption"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02737",
    "question": "What is associated with Hypothyroidism due to deficient transcription factors involved in pituitary development or function?",
    "seeds": [
      "Hypothyroidism due to deficient transcription factors involved in pituitary development or function"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02738",
    "question": "What is associated with Cervical spinal canal stenosis?",
    "seeds": [
      "Cervical spinal canal stenosis"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02739",
    "question": "What is associated with Lower limb undergrowth?",
    "seeds": [
      "Lower limb undergrowth"
    ],
    "gold_answer": "Aplasia/hypoplasia of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02740",
    "question": "What is associated with Elevated circulating uroporphyrin concentration?",
    "seeds": [
      "Elevated circulating uroporphyrin concentration"
    ],
    "gold_answer": "Elevated circulating porphyrin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02741",
    "question": "What is associated with Alar cleft, isolated?",
    "seeds": [
      "Alar cleft, isolated"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02742",
    "question": "What is associated with Facial hyperostosis?",
    "seeds": [
      "Facial hyperostosis"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02743",
    "question": "What is associated with Abnormal OCT-measured macular thickness?",
    "seeds": [
      "Abnormal OCT-measured macular thickness"
    ],
    "gold_answer": "Abnormal optical coherence tomography",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02744",
    "question": "What is associated with Increased airway neuroepithelial bodies?",
    "seeds": [
      "Increased airway neuroepithelial bodies"
    ],
    "gold_answer": "Abnormal bronchus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02745",
    "question": "What is associated with Glomerular endothelial tubuloreticular inclusion?",
    "seeds": [
      "Glomerular endothelial tubuloreticular inclusion"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02746",
    "question": "What is associated with Abnormal lung lobation?",
    "seeds": [
      "Abnormal lung lobation"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02747",
    "question": "What is associated with Congenital enterovirus infection?",
    "seeds": [
      "Congenital enterovirus infection"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02748",
    "question": "What is associated with Short middle phalanx of the 5th toe?",
    "seeds": [
      "Short middle phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the middle phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02749",
    "question": "What is associated with Round spermatid arrest?",
    "seeds": [
      "Round spermatid arrest"
    ],
    "gold_answer": "Functional abnormality of male internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02750",
    "question": "What is associated with Thomsen and Becker disease?",
    "seeds": [
      "Thomsen and Becker disease"
    ],
    "gold_answer": "CLCN1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_02751",
    "question": "What is associated with Skin ulcer?",
    "seeds": [
      "Skin ulcer"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02752",
    "question": "What is associated with Atypical sensory examination of objects?",
    "seeds": [
      "Atypical sensory examination of objects"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02753",
    "question": "What is associated with Abnormal nasal dorsum morphology?",
    "seeds": [
      "Abnormal nasal dorsum morphology"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02754",
    "question": "What is associated with Amyloid deposition by anatomical site?",
    "seeds": [
      "Amyloid deposition by anatomical site"
    ],
    "gold_answer": "Amyloid deposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02755",
    "question": "What is associated with Abnormal facial shape?",
    "seeds": [
      "Abnormal facial shape"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02756",
    "question": "What is associated with Decreased methylmalonyl-CoA mutase activity?",
    "seeds": [
      "Decreased methylmalonyl-CoA mutase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02757",
    "question": "What phenotype is associated with Nabais Sa-de vries syndrome, type 2?",
    "seeds": [
      "Nabais Sa-de vries syndrome, type 2"
    ],
    "gold_answer": "Sleep apnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02758",
    "question": "What is associated with KCNQ2-related developmental and epileptic encephalopathy?",
    "seeds": [
      "KCNQ2-related developmental and epileptic encephalopathy"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02759",
    "question": "What is associated with Elevated urinary 5-hydroxymethyluracil level?",
    "seeds": [
      "Elevated urinary 5-hydroxymethyluracil level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02760",
    "question": "What is associated with Patchy sclerosis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Patchy sclerosis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Patchy osteosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02761",
    "question": "What is associated with Hypoplastic dermoepidermal hemidesmosomes?",
    "seeds": [
      "Hypoplastic dermoepidermal hemidesmosomes"
    ],
    "gold_answer": "Abnormal dermoepidermal hemidesmosome morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02762",
    "question": "What is associated with Eosinophilic ascites?",
    "seeds": [
      "Eosinophilic ascites"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02763",
    "question": "What phenotype is associated with Combined oxidative phosphorylation deficiency 8?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 8"
    ],
    "gold_answer": "Reduced left ventricular ejection fraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02764",
    "question": "What is associated with Decreased specific antibody response to vaccination?",
    "seeds": [
      "Decreased specific antibody response to vaccination"
    ],
    "gold_answer": "Decreased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02765",
    "question": "What is associated with Hematuria, benign familial?",
    "seeds": [
      "Hematuria, benign familial"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02766",
    "question": "What is associated with Tenesmus?",
    "seeds": [
      "Tenesmus"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02767",
    "question": "What is associated with Severe constriction of peripheral visual field?",
    "seeds": [
      "Severe constriction of peripheral visual field"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02768",
    "question": "What is associated with Coronary sinus enlargement?",
    "seeds": [
      "Coronary sinus enlargement"
    ],
    "gold_answer": "Abnormal coronary sinus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02769",
    "question": "What is associated with Ivory epiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Ivory epiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Ivory epiphyses of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02770",
    "question": "What is associated with Bowed forearm bones?",
    "seeds": [
      "Bowed forearm bones"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02771",
    "question": "What phenotype is associated with 13q12.3 microdeletion syndrome?",
    "seeds": [
      "13q12.3 microdeletion syndrome"
    ],
    "gold_answer": "Respiratory distress",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02772",
    "question": "What is associated with Toenail onycholysis?",
    "seeds": [
      "Toenail onycholysis"
    ],
    "gold_answer": "Onycholysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02773",
    "question": "What phenotype is associated with Familial paroxysmal ataxia?",
    "seeds": [
      "Familial paroxysmal ataxia"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02774",
    "question": "What is associated with Nijmegen breakage syndrome-like disorder?",
    "seeds": [
      "Nijmegen breakage syndrome-like disorder"
    ],
    "gold_answer": "Abnormality of chromosome stability",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02775",
    "question": "What is associated with Tufted angioma?",
    "seeds": [
      "Tufted angioma"
    ],
    "gold_answer": "Heterotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02776",
    "question": "What phenotype is associated with Wolman disease?",
    "seeds": [
      "Wolman disease"
    ],
    "gold_answer": "Vomiting",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02777",
    "question": "What is associated with Increased urine 4-hydroxy-2-oxoglutarate level?",
    "seeds": [
      "Increased urine 4-hydroxy-2-oxoglutarate level"
    ],
    "gold_answer": "Abnormal urine pH",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02778",
    "question": "What is associated with Osteolytic defects of the proximal phalanx of the hallux?",
    "seeds": [
      "Osteolytic defects of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal morphology of the proximal phalanx of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02779",
    "question": "What is associated with Caroli syndrome?",
    "seeds": [
      "Caroli syndrome"
    ],
    "gold_answer": "Renal cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02780",
    "question": "What is associated with Accessory spleen?",
    "seeds": [
      "Accessory spleen"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02781",
    "question": "What is associated with Anti-glycosylphosphatidylinositol anchored high-density lipoprotein binding protein 1 antibody positivity?",
    "seeds": [
      "Anti-glycosylphosphatidylinositol anchored high-density lipoprotein binding protein 1 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02782",
    "question": "What is associated with Club-shaped proximal femur?",
    "seeds": [
      "Club-shaped proximal femur"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02783",
    "question": "What phenotype is associated with Microphthalmia, isolated, with coloboma 6?",
    "seeds": [
      "Microphthalmia, isolated, with coloboma 6"
    ],
    "gold_answer": "Optic disc hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02784",
    "question": "What is associated with Anti-neutrophil elastase antibody positivity?",
    "seeds": [
      "Anti-neutrophil elastase antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02785",
    "question": "What is associated with Typical urticaria pigmentosa?",
    "seeds": [
      "Typical urticaria pigmentosa"
    ],
    "gold_answer": "KIT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02786",
    "question": "What is associated with Microcephaly 14, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 14, primary, autosomal recessive"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02787",
    "question": "What is associated with Auditory neuropathy, autosomal dominant, 1?",
    "seeds": [
      "Auditory neuropathy, autosomal dominant, 1"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02788",
    "question": "What is associated with Ambiguous genitalia, female?",
    "seeds": [
      "Ambiguous genitalia, female"
    ],
    "gold_answer": "Abnormal female external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02789",
    "question": "What is associated with Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies?",
    "seeds": [
      "Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies"
    ],
    "gold_answer": "Feeding difficulties in infancy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02790",
    "question": "What is associated with Systemic autoinflammation?",
    "seeds": [
      "Systemic autoinflammation"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02791",
    "question": "What is associated with Olivopontocerebellar hypoplasia?",
    "seeds": [
      "Olivopontocerebellar hypoplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02792",
    "question": "What is associated with Mitochondrial DNA depletion syndrome 16B (neuroophthalmic type)?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 16B (neuroophthalmic type)"
    ],
    "gold_answer": "Peripheral neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02793",
    "question": "What is associated with Impairment of activities of daily living?",
    "seeds": [
      "Impairment of activities of daily living"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02794",
    "question": "What phenotype is associated with Copper deficiency, familial benign?",
    "seeds": [
      "Copper deficiency, familial benign"
    ],
    "gold_answer": "Curly hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02795",
    "question": "What phenotype is associated with Johnson neuroectodermal syndrome?",
    "seeds": [
      "Johnson neuroectodermal syndrome"
    ],
    "gold_answer": "Dolichocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02796",
    "question": "What is associated with Absent lacrimal punctum?",
    "seeds": [
      "Absent lacrimal punctum"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02797",
    "question": "What is associated with Pulmonary hemosiderosis?",
    "seeds": [
      "Pulmonary hemosiderosis"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02798",
    "question": "What phenotype is associated with Primordial dwarfism-immunodeficiency-lipodystrophy syndrome?",
    "seeds": [
      "Primordial dwarfism-immunodeficiency-lipodystrophy syndrome"
    ],
    "gold_answer": "Accessory spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02799",
    "question": "What is associated with Abnormal naive CD4+ T cell proportion?",
    "seeds": [
      "Abnormal naive CD4+ T cell proportion"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02800",
    "question": "What is associated with Male urethral meatus stenosis?",
    "seeds": [
      "Male urethral meatus stenosis"
    ],
    "gold_answer": "Urethral stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02801",
    "question": "What is associated with Spondylitis?",
    "seeds": [
      "Spondylitis"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02802",
    "question": "What is associated with Long thumb?",
    "seeds": [
      "Long thumb"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02803",
    "question": "What is associated with Colpocephaly?",
    "seeds": [
      "Colpocephaly"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02804",
    "question": "What is associated with Spastic/hyperactive bladder?",
    "seeds": [
      "Spastic/hyperactive bladder"
    ],
    "gold_answer": "Abnormality of the lower urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02805",
    "question": "What is associated with Spinocerebellar ataxia 13?",
    "seeds": [
      "Spinocerebellar ataxia 13"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02806",
    "question": "What is associated with Lynch syndrome I?",
    "seeds": [
      "Lynch syndrome I"
    ],
    "gold_answer": "Neoplasm of the colon",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02807",
    "question": "What is associated with Abnormal inferior vena cava morphology?",
    "seeds": [
      "Abnormal inferior vena cava morphology"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02808",
    "question": "What phenotype is associated with Arterial calcification, generalized, of infancy, 2?",
    "seeds": [
      "Arterial calcification, generalized, of infancy, 2"
    ],
    "gold_answer": "Orthopnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02809",
    "question": "What is associated with Libman-Sacks lesions?",
    "seeds": [
      "Libman-Sacks lesions"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02810",
    "question": "What is associated with Abnormal circulating carnosine concentration?",
    "seeds": [
      "Abnormal circulating carnosine concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02811",
    "question": "What is associated with Pseudoepiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Pseudoepiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Pseudoepiphyses of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02812",
    "question": "What is associated with Extrapulmonary tuberculosis?",
    "seeds": [
      "Extrapulmonary tuberculosis"
    ],
    "gold_answer": "Opportunistic infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02813",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 23?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 23"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02814",
    "question": "What is associated with Parotitis?",
    "seeds": [
      "Parotitis"
    ],
    "gold_answer": "Abnormal salivary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02815",
    "question": "What is associated with Decreased circulating chenodeoxycholic acid concentration?",
    "seeds": [
      "Decreased circulating chenodeoxycholic acid concentration"
    ],
    "gold_answer": "Decreased serum bile acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02816",
    "question": "What phenotype is associated with Pediatric systemic lupus erythematosus?",
    "seeds": [
      "Pediatric systemic lupus erythematosus"
    ],
    "gold_answer": "Nephrotic syndrome",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02817",
    "question": "What phenotype is associated with Rubinstein-Taybi syndrome due to CREBBP mutations?",
    "seeds": [
      "Rubinstein-Taybi syndrome due to CREBBP mutations"
    ],
    "gold_answer": "Abnormality of the posterior cranial fossa",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02818",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia, Shohat type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, Shohat type"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02819",
    "question": "What phenotype is associated with Choroidal dystrophy, central areolar 3?",
    "seeds": [
      "Choroidal dystrophy, central areolar 3"
    ],
    "gold_answer": "Drusen",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02820",
    "question": "What is associated with Short middle phalanx of the 4th toe?",
    "seeds": [
      "Short middle phalanx of the 4th toe"
    ],
    "gold_answer": "Short phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02821",
    "question": "What is associated with Abnormal doll's eye reflex?",
    "seeds": [
      "Abnormal doll's eye reflex"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02822",
    "question": "What is associated with Absent epiphysis of the middle phalanx of the 5th toe?",
    "seeds": [
      "Absent epiphysis of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02823",
    "question": "What is associated with Episodic pain syndrome, familial, 1?",
    "seeds": [
      "Episodic pain syndrome, familial, 1"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02824",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2S?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2S"
    ],
    "gold_answer": "Talipes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02825",
    "question": "What is associated with Perilobar nephrogenic rest?",
    "seeds": [
      "Perilobar nephrogenic rest"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02826",
    "question": "What is associated with PEHO-like syndrome?",
    "seeds": [
      "PEHO-like syndrome"
    ],
    "gold_answer": "CCDC88A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_02827",
    "question": "What is associated with Acrodermatitis enteropathica?",
    "seeds": [
      "Acrodermatitis enteropathica"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02828",
    "question": "What is associated with Optic pathway glioma?",
    "seeds": [
      "Optic pathway glioma"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02829",
    "question": "What is associated with Persistent falcine venous sinus?",
    "seeds": [
      "Persistent falcine venous sinus"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02830",
    "question": "What is associated with Increased hemoglobin oxygen affinity?",
    "seeds": [
      "Increased hemoglobin oxygen affinity"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02831",
    "question": "What phenotype is associated with Epidermolysis bullosa simplex with mottled pigmentation?",
    "seeds": [
      "Epidermolysis bullosa simplex with mottled pigmentation"
    ],
    "gold_answer": "Oral mucosal blisters",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02832",
    "question": "What is associated with Agnathia-Otocephaly complex?",
    "seeds": [
      "Agnathia-Otocephaly complex"
    ],
    "gold_answer": "Atrial septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02833",
    "question": "What is associated with Adult hepatocellular carcinoma?",
    "seeds": [
      "Adult hepatocellular carcinoma"
    ],
    "gold_answer": "EGF",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_02834",
    "question": "What is associated with Delayed ossification of the clavicle?",
    "seeds": [
      "Delayed ossification of the clavicle"
    ],
    "gold_answer": "Abnormal clavicle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02835",
    "question": "What is associated with Thyroid carcinoma?",
    "seeds": [
      "Thyroid carcinoma"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02836",
    "question": "What is associated with Yellow nail syndrome?",
    "seeds": [
      "Yellow nail syndrome"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02837",
    "question": "What is associated with HYDROXYPROLINEMIA?",
    "seeds": [
      "HYDROXYPROLINEMIA"
    ],
    "gold_answer": "Hematuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02838",
    "question": "What is associated with Low 10-minute APGAR score?",
    "seeds": [
      "Low 10-minute APGAR score"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02839",
    "question": "What is associated with Hypoplastic left ventricle?",
    "seeds": [
      "Hypoplastic left ventricle"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02840",
    "question": "What is associated with Developmental cataract?",
    "seeds": [
      "Developmental cataract"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02841",
    "question": "What is associated with Spherocytosis?",
    "seeds": [
      "Spherocytosis"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02842",
    "question": "What is associated with Elevated circulating C-terminal telopeptide cross-link of type1 collagen concentration?",
    "seeds": [
      "Elevated circulating C-terminal telopeptide cross-link of type1 collagen concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02843",
    "question": "What is associated with Neurodegeneration with ataxia and late-onset optic atrophy?",
    "seeds": [
      "Neurodegeneration with ataxia and late-onset optic atrophy"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02844",
    "question": "What is associated with Dark choroid?",
    "seeds": [
      "Dark choroid"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02845",
    "question": "What is associated with Osteoarthritis of the distal interphalangeal joint?",
    "seeds": [
      "Osteoarthritis of the distal interphalangeal joint"
    ],
    "gold_answer": "Osteoarthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02846",
    "question": "What is associated with Globe retraction and deviation on abduction?",
    "seeds": [
      "Globe retraction and deviation on abduction"
    ],
    "gold_answer": "Abnormality of ocular abduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02847",
    "question": "What is associated with Dust particle inclusion in alveolar macrophages?",
    "seeds": [
      "Dust particle inclusion in alveolar macrophages"
    ],
    "gold_answer": "Abnormal alveolar macrophage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02848",
    "question": "What is associated with Centralopathic epilepsy?",
    "seeds": [
      "Centralopathic epilepsy"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02849",
    "question": "What is associated with Midline brain calcifications?",
    "seeds": [
      "Midline brain calcifications"
    ],
    "gold_answer": "Ectopic calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02850",
    "question": "What is associated with Acrogeria?",
    "seeds": [
      "Acrogeria"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02851",
    "question": "What is associated with Positive Dengue virus PCR test in the blood circulation?",
    "seeds": [
      "Positive Dengue virus PCR test in the blood circulation"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02852",
    "question": "What phenotype is associated with Glycerol kinase deficiency?",
    "seeds": [
      "Glycerol kinase deficiency"
    ],
    "gold_answer": "Chronic pancreatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02853",
    "question": "What is associated with Brachmann-De lange-like facial changes with microcephaly, metatarsusadductus, and developmental delay?",
    "seeds": [
      "Brachmann-De lange-like facial changes with microcephaly, metatarsusadductus, and developmental delay"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02854",
    "question": "What is associated with Autosomal dominant inheritance?",
    "seeds": [
      "Autosomal dominant inheritance"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02855",
    "question": "What is associated with Hypotension?",
    "seeds": [
      "Hypotension"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02856",
    "question": "What is associated with Expanded metacarpals with widened medullary cavities?",
    "seeds": [
      "Expanded metacarpals with widened medullary cavities"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02857",
    "question": "What is associated with Autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome?",
    "seeds": [
      "Autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome"
    ],
    "gold_answer": "Abnormal tongue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02858",
    "question": "What is associated with Jessner lymphocytic infiltration of the skin?",
    "seeds": [
      "Jessner lymphocytic infiltration of the skin"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02859",
    "question": "What is associated with Amplification of relationship seeking?",
    "seeds": [
      "Amplification of relationship seeking"
    ],
    "gold_answer": "Abnormal social behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02860",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 24?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 24"
    ],
    "gold_answer": "Abnormal nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02861",
    "question": "What is associated with Skin infectious agent?",
    "seeds": [
      "Skin infectious agent"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02862",
    "question": "What is associated with Peripheral hypermyelination?",
    "seeds": [
      "Peripheral hypermyelination"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02863",
    "question": "What is associated with Bleeding disorder, platelet-type, 13, susceptibility to?",
    "seeds": [
      "Bleeding disorder, platelet-type, 13, susceptibility to"
    ],
    "gold_answer": "Abnormal platelet morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02864",
    "question": "What is associated with Renovascular hypertension?",
    "seeds": [
      "Renovascular hypertension"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02865",
    "question": "What is associated with Decreased circulating selenium concentration?",
    "seeds": [
      "Decreased circulating selenium concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02866",
    "question": "What is associated with Hypopigmentation of the skin?",
    "seeds": [
      "Hypopigmentation of the skin"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02867",
    "question": "What is associated with Tibialis muscle weakness?",
    "seeds": [
      "Tibialis muscle weakness"
    ],
    "gold_answer": "Lower limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02868",
    "question": "What phenotype is associated with Distal deletion 10p syndrome?",
    "seeds": [
      "Distal deletion 10p syndrome"
    ],
    "gold_answer": "Intrauterine growth retardation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02869",
    "question": "What phenotype is associated with Cleft palate, cardiac defect, genital anomalies, and ectrodactyly?",
    "seeds": [
      "Cleft palate, cardiac defect, genital anomalies, and ectrodactyly"
    ],
    "gold_answer": "Macrotia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02870",
    "question": "What phenotype is associated with Kleefstra syndrome due to 9q34 microdeletion?",
    "seeds": [
      "Kleefstra syndrome due to 9q34 microdeletion"
    ],
    "gold_answer": "Cardiomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02871",
    "question": "What is associated with Salter V fracture?",
    "seeds": [
      "Salter V fracture"
    ],
    "gold_answer": "Fracture type",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02872",
    "question": "What is associated with Vitamin d-dependent rickets, type 2A?",
    "seeds": [
      "Vitamin d-dependent rickets, type 2A"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02873",
    "question": "What is associated with Abnormal optic disc vasculature morphology?",
    "seeds": [
      "Abnormal optic disc vasculature morphology"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02874",
    "question": "What is associated with Focal impaired awareness cognitive seizure with expressive dysphasia/aphasia?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with expressive dysphasia/aphasia"
    ],
    "gold_answer": "Focal impaired awareness cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02875",
    "question": "What is associated with Hallux pain?",
    "seeds": [
      "Hallux pain"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02876",
    "question": "What is associated with Wrist instability?",
    "seeds": [
      "Wrist instability"
    ],
    "gold_answer": "Abnormality of the wrist",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02877",
    "question": "What is associated with Abnormal gamma-delta T cell proportion?",
    "seeds": [
      "Abnormal gamma-delta T cell proportion"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02878",
    "question": "What is associated with Papillary renal cell carcinoma type 1?",
    "seeds": [
      "Papillary renal cell carcinoma type 1"
    ],
    "gold_answer": "Papillary renal cell carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02879",
    "question": "What is associated with Benign gastrointestinal tract tumors?",
    "seeds": [
      "Benign gastrointestinal tract tumors"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02880",
    "question": "What phenotype is associated with Corneal dystrophy, Reis-Bucklers type?",
    "seeds": [
      "Corneal dystrophy, Reis-Bucklers type"
    ],
    "gold_answer": "Corneal opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02881",
    "question": "What is associated with Aplasia/Hypoplasia of the phalanges of the 4th finger?",
    "seeds": [
      "Aplasia/Hypoplasia of the phalanges of the 4th finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02882",
    "question": "What is associated with Abnormal CNS myelination?",
    "seeds": [
      "Abnormal CNS myelination"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02883",
    "question": "What is associated with Lateral canthal tendon laxity?",
    "seeds": [
      "Lateral canthal tendon laxity"
    ],
    "gold_answer": "Abnormal eyelid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02884",
    "question": "What is associated with Triggered by exertion?",
    "seeds": [
      "Triggered by exertion"
    ],
    "gold_answer": "Triggered by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02885",
    "question": "What is associated with Encephalopathy?",
    "seeds": [
      "Encephalopathy"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02886",
    "question": "What is associated with Sclerosis of the middle phalanx of the 2nd toe?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02887",
    "question": "What is associated with Myopathic facies?",
    "seeds": [
      "Myopathic facies"
    ],
    "gold_answer": "Decreased facial expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02888",
    "question": "What is associated with Abnormality of the calf?",
    "seeds": [
      "Abnormality of the calf"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02889",
    "question": "What is associated with Elevated circulating D-dimer concentration?",
    "seeds": [
      "Elevated circulating D-dimer concentration"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02890",
    "question": "What is associated with Thumb hypoplasia grade 1?",
    "seeds": [
      "Thumb hypoplasia grade 1"
    ],
    "gold_answer": "Short finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02891",
    "question": "What is associated with Idiosyncratic gesture?",
    "seeds": [
      "Idiosyncratic gesture"
    ],
    "gold_answer": "Abnormal gesture use",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02892",
    "question": "What is associated with Dihydrolipoamide dehydrogenase deficiency?",
    "seeds": [
      "Dihydrolipoamide dehydrogenase deficiency"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02893",
    "question": "What is associated with Avascular necrosis of femoral head, primary, 2?",
    "seeds": [
      "Avascular necrosis of femoral head, primary, 2"
    ],
    "gold_answer": "Avascular necrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02894",
    "question": "What is associated with Cone-shaped epiphysis of the thumb?",
    "seeds": [
      "Cone-shaped epiphysis of the thumb"
    ],
    "gold_answer": "Phalangeal cone-shaped epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02895",
    "question": "What is associated with Patchy sclerosis of thumb phalanx?",
    "seeds": [
      "Patchy sclerosis of thumb phalanx"
    ],
    "gold_answer": "Sclerosis of thumb phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02896",
    "question": "What is associated with Acinetobacter infection?",
    "seeds": [
      "Acinetobacter infection"
    ],
    "gold_answer": "Opportunistic infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02897",
    "question": "What is associated with Irregular dentition?",
    "seeds": [
      "Irregular dentition"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02898",
    "question": "What is associated with Inferior oblique muscle underaction?",
    "seeds": [
      "Inferior oblique muscle underaction"
    ],
    "gold_answer": "Inferior oblique muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02899",
    "question": "What is associated with Aplasia/Hypoplasia involving bones of the feet?",
    "seeds": [
      "Aplasia/Hypoplasia involving bones of the feet"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02900",
    "question": "What is associated with Anti-Th/To antibody positivity?",
    "seeds": [
      "Anti-Th/To antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02901",
    "question": "What is associated with FUTCHER LINE?",
    "seeds": [
      "FUTCHER LINE"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02902",
    "question": "What is associated with Abnormality of the epiphyses of the 4th finger?",
    "seeds": [
      "Abnormality of the epiphyses of the 4th finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02903",
    "question": "What is associated with Curved distal toe phalanx?",
    "seeds": [
      "Curved distal toe phalanx"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02904",
    "question": "What is associated with Limb-mammary syndrome?",
    "seeds": [
      "Limb-mammary syndrome"
    ],
    "gold_answer": "Abnormality of the menstrual cycle",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02905",
    "question": "What is associated with Aplasia/Hypoplasia of the ulna?",
    "seeds": [
      "Aplasia/Hypoplasia of the ulna"
    ],
    "gold_answer": "Aplasia/hypoplasia involving forearm bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02906",
    "question": "What is associated with Metacarpal synostosis?",
    "seeds": [
      "Metacarpal synostosis"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02907",
    "question": "What is associated with Late-onset spinocerebellar degeneration?",
    "seeds": [
      "Late-onset spinocerebellar degeneration"
    ],
    "gold_answer": "Spinocerebellar tract degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02908",
    "question": "What is associated with Tricho-dento-osseous syndrome?",
    "seeds": [
      "Tricho-dento-osseous syndrome"
    ],
    "gold_answer": "Selective tooth agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02909",
    "question": "What is associated with Abnormality of the ocular adnexa?",
    "seeds": [
      "Abnormality of the ocular adnexa"
    ],
    "gold_answer": "Abnormality of the orbital region",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02910",
    "question": "What is associated with Focal sexual automatism seizure?",
    "seeds": [
      "Focal sexual automatism seizure"
    ],
    "gold_answer": "Focal motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02911",
    "question": "What is associated with Perineal?",
    "seeds": [
      "Perineal"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02912",
    "question": "What is associated with Positive mycobacterium CSF culture?",
    "seeds": [
      "Positive mycobacterium CSF culture"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02913",
    "question": "What is associated with Testicular teratoma?",
    "seeds": [
      "Testicular teratoma"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02914",
    "question": "What is associated with Nevus comedonicus, somatic?",
    "seeds": [
      "Nevus comedonicus, somatic"
    ],
    "gold_answer": "Nevus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02915",
    "question": "What is associated with Elevated erythrocyte sedimentation rate?",
    "seeds": [
      "Elevated erythrocyte sedimentation rate"
    ],
    "gold_answer": "Acute phase response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02916",
    "question": "What is associated with Posterior rib cupping?",
    "seeds": [
      "Posterior rib cupping"
    ],
    "gold_answer": "Cupped ribs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02917",
    "question": "What is associated with Duplication of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Duplication of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Duplication of phalanx of 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02918",
    "question": "What is associated with Febrile seizures, familial, 6?",
    "seeds": [
      "Febrile seizures, familial, 6"
    ],
    "gold_answer": "Infection-related seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02919",
    "question": "What is associated with Esophageal stricture?",
    "seeds": [
      "Esophageal stricture"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02920",
    "question": "What is associated with Striatonigral degeneration, childhood-onset?",
    "seeds": [
      "Striatonigral degeneration, childhood-onset"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02921",
    "question": "What is associated with Sertoli cell-only syndrome?",
    "seeds": [
      "Sertoli cell-only syndrome"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02922",
    "question": "What is associated with Ohdo syndrome, X-linked?",
    "seeds": [
      "Ohdo syndrome, X-linked"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the mandible",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02923",
    "question": "What is associated with Frontonasal dysplasia 3?",
    "seeds": [
      "Frontonasal dysplasia 3"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02924",
    "question": "What is associated with Dyssegmental dysplasia, Rolland-Desbuquois type?",
    "seeds": [
      "Dyssegmental dysplasia, Rolland-Desbuquois type"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02925",
    "question": "What is associated with Renal interstitial foam cells?",
    "seeds": [
      "Renal interstitial foam cells"
    ],
    "gold_answer": "Abnormal renal interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02926",
    "question": "What is associated with Ciliary body coloboma?",
    "seeds": [
      "Ciliary body coloboma"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02927",
    "question": "What is associated with Elevated urine aconitic acid level?",
    "seeds": [
      "Elevated urine aconitic acid level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02928",
    "question": "What is associated with Febrile seizure (within the age range of 3 months to 6 years)?",
    "seeds": [
      "Febrile seizure (within the age range of 3 months to 6 years)"
    ],
    "gold_answer": "Infection-related seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02929",
    "question": "What is associated with Left-right disorientation?",
    "seeds": [
      "Left-right disorientation"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02930",
    "question": "What is associated with Nystagmus, myoclonic?",
    "seeds": [
      "Nystagmus, myoclonic"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02931",
    "question": "What is associated with Elevated urinary glutarylglycine level?",
    "seeds": [
      "Elevated urinary glutarylglycine level"
    ],
    "gold_answer": "Aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02932",
    "question": "What is associated with Chronic pulmonary obstruction?",
    "seeds": [
      "Chronic pulmonary obstruction"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02933",
    "question": "What is associated with High-pitched bowel sounds?",
    "seeds": [
      "High-pitched bowel sounds"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02934",
    "question": "What is associated with Fetal ultrasound soft marker?",
    "seeds": [
      "Fetal ultrasound soft marker"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02935",
    "question": "What is associated with Peeling skin syndrome 1?",
    "seeds": [
      "Peeling skin syndrome 1"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02936",
    "question": "What is associated with Alopecia antibody deficiency?",
    "seeds": [
      "Alopecia antibody deficiency"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02937",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 76?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 76"
    ],
    "gold_answer": "Precocious puberty",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02938",
    "question": "What phenotype is associated with Dentin dysplasia, type II?",
    "seeds": [
      "Dentin dysplasia, type II"
    ],
    "gold_answer": "Thistle tube shaped pulp",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02939",
    "question": "What phenotype is associated with Factor V and factor VIII, combined deficiency of, with normal proteinc and protein C inhibitor?",
    "seeds": [
      "Factor V and factor VIII, combined deficiency of, with normal proteinc and protein C inhibitor"
    ],
    "gold_answer": "Reduced coagulation factor V activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02940",
    "question": "What is associated with Abnormal sweat electrolytes?",
    "seeds": [
      "Abnormal sweat electrolytes"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02941",
    "question": "What is associated with Abolished vibration sense?",
    "seeds": [
      "Abolished vibration sense"
    ],
    "gold_answer": "Somatic sensory dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02942",
    "question": "What is associated with Pink urine?",
    "seeds": [
      "Pink urine"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02943",
    "question": "What is associated with Altman type III sacrococcygeal teratoma?",
    "seeds": [
      "Altman type III sacrococcygeal teratoma"
    ],
    "gold_answer": "Teratoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02944",
    "question": "What is associated with Calcification of cartilage?",
    "seeds": [
      "Calcification of cartilage"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02945",
    "question": "What is associated with Anti-Gephyrin antibody?",
    "seeds": [
      "Anti-Gephyrin antibody"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02946",
    "question": "What is associated with Hypospadias?",
    "seeds": [
      "Hypospadias"
    ],
    "gold_answer": "Abnormal male urethral meatus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02947",
    "question": "What is associated with Neurodevelopmental disorder with ataxia and brain abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with ataxia and brain abnormalities"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02948",
    "question": "What is associated with Aganglionosis of the small intestine?",
    "seeds": [
      "Aganglionosis of the small intestine"
    ],
    "gold_answer": "Abnormal enteric nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02949",
    "question": "What is associated with EEM syndrome?",
    "seeds": [
      "EEM syndrome"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02950",
    "question": "What is associated with Abnormal gesture use?",
    "seeds": [
      "Abnormal gesture use"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02951",
    "question": "What phenotype is associated with Alzheimer disease 4?",
    "seeds": [
      "Alzheimer disease 4"
    ],
    "gold_answer": "Parkinsonism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02952",
    "question": "What is associated with Male infertility due to large-headed multiflagellar polyploid spermatozoa?",
    "seeds": [
      "Male infertility due to large-headed multiflagellar polyploid spermatozoa"
    ],
    "gold_answer": "AKAP3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_02953",
    "question": "What is associated with Deafness, congenital neurosensory, autosomal recessive 38?",
    "seeds": [
      "Deafness, congenital neurosensory, autosomal recessive 38"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02954",
    "question": "What is associated with Abnormal muscle fiber alpha dystroglycan?",
    "seeds": [
      "Abnormal muscle fiber alpha dystroglycan"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02955",
    "question": "What is associated with Late infantile CLN2 disease?",
    "seeds": [
      "Late infantile CLN2 disease"
    ],
    "gold_answer": "TPP1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02956",
    "question": "What is associated with Abnormal posterior semicircular canal morphology?",
    "seeds": [
      "Abnormal posterior semicircular canal morphology"
    ],
    "gold_answer": "Abnormal morphology of the vestibule of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02957",
    "question": "What is associated with Fibrillary glomerular subepithelial deposits?",
    "seeds": [
      "Fibrillary glomerular subepithelial deposits"
    ],
    "gold_answer": "Glomerular subepithelial deposits",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02958",
    "question": "What is associated with Spermatogenic failure 78?",
    "seeds": [
      "Spermatogenic failure 78"
    ],
    "gold_answer": "Abnormal preimplantation embryonic development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02959",
    "question": "What is associated with Functional abnormality of male internal genitalia?",
    "seeds": [
      "Functional abnormality of male internal genitalia"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02960",
    "question": "What is associated with Motor deterioration?",
    "seeds": [
      "Motor deterioration"
    ],
    "gold_answer": "Cognitive impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02961",
    "question": "What is associated with Aplasia of the musculature of the pelvis?",
    "seeds": [
      "Aplasia of the musculature of the pelvis"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the musculature of the pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02962",
    "question": "What is associated with Gastric intraepithelial lymphocytosis?",
    "seeds": [
      "Gastric intraepithelial lymphocytosis"
    ],
    "gold_answer": "Abnormal stomach morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02963",
    "question": "What is associated with Lunotriquetral interval widening?",
    "seeds": [
      "Lunotriquetral interval widening"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02964",
    "question": "What is associated with Temporal pattern?",
    "seeds": [
      "Temporal pattern"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02965",
    "question": "What is associated with Anomalous muscle bundle of the right ventricle?",
    "seeds": [
      "Anomalous muscle bundle of the right ventricle"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02966",
    "question": "What is associated with Absent epiphysis of the middle phalanx of the 2nd toe?",
    "seeds": [
      "Absent epiphysis of the middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Absent epiphyses of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02967",
    "question": "What is associated with Glomerular endocapillary hypercellularity?",
    "seeds": [
      "Glomerular endocapillary hypercellularity"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02968",
    "question": "What is associated with Ophthalmoplegia?",
    "seeds": [
      "Ophthalmoplegia"
    ],
    "gold_answer": "Ophthalmoparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02969",
    "question": "What phenotype is associated with Symphalangism of toes?",
    "seeds": [
      "Symphalangism of toes"
    ],
    "gold_answer": "Toe phalanx synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02970",
    "question": "What is associated with Low intraocular pressure?",
    "seeds": [
      "Low intraocular pressure"
    ],
    "gold_answer": "Abnormal intraocular pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02971",
    "question": "What is associated with Unilateral facial palsy?",
    "seeds": [
      "Unilateral facial palsy"
    ],
    "gold_answer": "Weakness of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02972",
    "question": "What is associated with Mixed phenotype acute leukemia with t(v;11q23.3)?",
    "seeds": [
      "Mixed phenotype acute leukemia with t(v;11q23.3)"
    ],
    "gold_answer": "FLT3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_02973",
    "question": "What is associated with Aplasia of the distal phalanx of the thumb?",
    "seeds": [
      "Aplasia of the distal phalanx of the thumb"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02974",
    "question": "What is associated with History of recent participation in athletics?",
    "seeds": [
      "History of recent participation in athletics"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02975",
    "question": "What phenotype is associated with Cohen-Gibson syndrome?",
    "seeds": [
      "Cohen-Gibson syndrome"
    ],
    "gold_answer": "Thin nail",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02976",
    "question": "What is associated with Lipodystrophy due to peptidic growth factors deficiency?",
    "seeds": [
      "Lipodystrophy due to peptidic growth factors deficiency"
    ],
    "gold_answer": "Abnormality of subcutaneous fat tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02977",
    "question": "What is associated with Macular pseudohole?",
    "seeds": [
      "Macular pseudohole"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02978",
    "question": "What is associated with Reduced factor XI activity?",
    "seeds": [
      "Reduced factor XI activity"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02979",
    "question": "What is associated with Cone-shaped epiphysis of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Cone-shaped epiphysis of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the proximal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02980",
    "question": "What is associated with Pseudoepiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Pseudoepiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02981",
    "question": "What is associated with Aplasia/Hypoplasia of the proximal phalanx of the thumb?",
    "seeds": [
      "Aplasia/Hypoplasia of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Abnormality of thumb phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02982",
    "question": "What is associated with Akathisia?",
    "seeds": [
      "Akathisia"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02983",
    "question": "What is associated with Elevated circulating DNAJB9 protein concentration?",
    "seeds": [
      "Elevated circulating DNAJB9 protein concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02984",
    "question": "What is associated with Arcuate artery endotheliosis?",
    "seeds": [
      "Arcuate artery endotheliosis"
    ],
    "gold_answer": "Abnormal arcuate artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02985",
    "question": "What is associated with Disseminated dermatophytosis?",
    "seeds": [
      "Disseminated dermatophytosis"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02986",
    "question": "What is associated with Frontonasal dysplasia with alar clefts?",
    "seeds": [
      "Frontonasal dysplasia with alar clefts"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02987",
    "question": "What is associated with Spastic paraplegia 64, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 64, autosomal recessive"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02988",
    "question": "What is associated with Telangiectasia, hereditary hemorrhagic, type 5?",
    "seeds": [
      "Telangiectasia, hereditary hemorrhagic, type 5"
    ],
    "gold_answer": "Abnormality of the hepatic vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02989",
    "question": "What is associated with Wrist pain?",
    "seeds": [
      "Wrist pain"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02990",
    "question": "What is associated with Thyroid agenesis?",
    "seeds": [
      "Thyroid agenesis"
    ],
    "gold_answer": "Abnormal thyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02991",
    "question": "What is associated with Histiocytosis, familial lipochrome?",
    "seeds": [
      "Histiocytosis, familial lipochrome"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02992",
    "question": "What is associated with Hereditary motor and sensory neuropathy VIA?",
    "seeds": [
      "Hereditary motor and sensory neuropathy VIA"
    ],
    "gold_answer": "Sensory neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02993",
    "question": "What is associated with Aplasia/Hypoplasia of the cerebellar vermis?",
    "seeds": [
      "Aplasia/Hypoplasia of the cerebellar vermis"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02994",
    "question": "What is associated with Meckel syndrome, type 7?",
    "seeds": [
      "Meckel syndrome, type 7"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02995",
    "question": "What is associated with Enlarged peroxisomes?",
    "seeds": [
      "Enlarged peroxisomes"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02996",
    "question": "What phenotype is associated with Proximal 5th toe symphalangism?",
    "seeds": [
      "Proximal 5th toe symphalangism"
    ],
    "gold_answer": "Finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_02997",
    "question": "What is associated with Granulomatosis with polyangiitis?",
    "seeds": [
      "Granulomatosis with polyangiitis"
    ],
    "gold_answer": "Abnormal platelet count",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02998",
    "question": "What is associated with Recurrent bronchopulmonary infections?",
    "seeds": [
      "Recurrent bronchopulmonary infections"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_02999",
    "question": "What is associated with Abnormal liver lobulation?",
    "seeds": [
      "Abnormal liver lobulation"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03000",
    "question": "What phenotype is associated with Lelis syndrome?",
    "seeds": [
      "Lelis syndrome"
    ],
    "gold_answer": "Exotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03001",
    "question": "What is associated with Elevated CSF guanidinoacetic acid concentration?",
    "seeds": [
      "Elevated CSF guanidinoacetic acid concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03002",
    "question": "What is associated with Thyrotoxicosis from ectopic thyroid tissue?",
    "seeds": [
      "Thyrotoxicosis from ectopic thyroid tissue"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03003",
    "question": "What is associated with Low-frequency hearing loss?",
    "seeds": [
      "Low-frequency hearing loss"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03004",
    "question": "What is associated with Migraine?",
    "seeds": [
      "Migraine"
    ],
    "gold_answer": "Headache",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03005",
    "question": "What is associated with Hypoplasia of mandible relative to maxilla?",
    "seeds": [
      "Hypoplasia of mandible relative to maxilla"
    ],
    "gold_answer": "Micrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03006",
    "question": "What is associated with Osteolysis of talus?",
    "seeds": [
      "Osteolysis of talus"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03007",
    "question": "What is associated with Transverse terminal lower limb defect?",
    "seeds": [
      "Transverse terminal lower limb defect"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03008",
    "question": "What is associated with Abnormal automated kinetic perimetry test?",
    "seeds": [
      "Abnormal automated kinetic perimetry test"
    ],
    "gold_answer": "Abnormal kinetic perimetry test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03009",
    "question": "What is associated with Optic atrophy 2?",
    "seeds": [
      "Optic atrophy 2"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03010",
    "question": "What is associated with Secondary hypoparathyroidism due to impaired parathormon secretion?",
    "seeds": [
      "Secondary hypoparathyroidism due to impaired parathormon secretion"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03011",
    "question": "What is associated with Developmental malformations-deafness-dystonia syndrome?",
    "seeds": [
      "Developmental malformations-deafness-dystonia syndrome"
    ],
    "gold_answer": "Ineffective esophageal peristalsis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03012",
    "question": "What is associated with Ankle swelling?",
    "seeds": [
      "Ankle swelling"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03013",
    "question": "What is associated with Reduced brain gamma-aminobutyric acid level by MRS?",
    "seeds": [
      "Reduced brain gamma-aminobutyric acid level by MRS"
    ],
    "gold_answer": "Brain imaging abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03014",
    "question": "What is associated with Pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome, neonatal lethal?",
    "seeds": [
      "Pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome, neonatal lethal"
    ],
    "gold_answer": "Abnormal penis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03015",
    "question": "What is associated with Abnormality of the curvature of the cornea?",
    "seeds": [
      "Abnormality of the curvature of the cornea"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03016",
    "question": "What phenotype is associated with Inclusion body myopathy with early-onset Paget disease without frontotemporal dementia 3?",
    "seeds": [
      "Inclusion body myopathy with early-onset Paget disease without frontotemporal dementia 3"
    ],
    "gold_answer": "Muscle fiber inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03017",
    "question": "What is associated with Small placenta?",
    "seeds": [
      "Small placenta"
    ],
    "gold_answer": "Abnormal placental size",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03018",
    "question": "What is associated with Olfactory sensory seeking?",
    "seeds": [
      "Olfactory sensory seeking"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03019",
    "question": "What is associated with Celiac artery dissection?",
    "seeds": [
      "Celiac artery dissection"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03020",
    "question": "What is associated with Positive CSF anti-measles antibody test?",
    "seeds": [
      "Positive CSF anti-measles antibody test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03021",
    "question": "What is associated with Slowly progressive?",
    "seeds": [
      "Slowly progressive"
    ],
    "gold_answer": "Progressive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03022",
    "question": "What is associated with Primary hyperoxaluria type 1?",
    "seeds": [
      "Primary hyperoxaluria type 1"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03023",
    "question": "What phenotype is associated with Spinocerebellar ataxia, autosomal recessive 7?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 7"
    ],
    "gold_answer": "Postural tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03024",
    "question": "What is associated with Anti-Gephyrin antibody?",
    "seeds": [
      "Anti-Gephyrin antibody"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03025",
    "question": "What is associated with Skin nodule?",
    "seeds": [
      "Skin nodule"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03026",
    "question": "What phenotype is associated with Vohwinkel syndrome, variant form?",
    "seeds": [
      "Vohwinkel syndrome, variant form"
    ],
    "gold_answer": "Hypergranulosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03027",
    "question": "What is associated with Generalized weakness of limb muscles?",
    "seeds": [
      "Generalized weakness of limb muscles"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03028",
    "question": "What phenotype is associated with Ichthyosis, split hairs, and amino aciduria?",
    "seeds": [
      "Ichthyosis, split hairs, and amino aciduria"
    ],
    "gold_answer": "Corneal erosion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03029",
    "question": "What phenotype is associated with Floating-Harbor syndrome?",
    "seeds": [
      "Floating-Harbor syndrome"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03030",
    "question": "What phenotype is associated with Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay?",
    "seeds": [
      "Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay"
    ],
    "gold_answer": "Profound global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03031",
    "question": "What is associated with Decreased corneal reflex?",
    "seeds": [
      "Decreased corneal reflex"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03032",
    "question": "What is associated with DK1-CDG?",
    "seeds": [
      "DK1-CDG"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03033",
    "question": "What is associated with Absent microvilli on the surface of peripheral blood lymphocytes?",
    "seeds": [
      "Absent microvilli on the surface of peripheral blood lymphocytes"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03034",
    "question": "What is associated with Medial calcification of small arteries?",
    "seeds": [
      "Medial calcification of small arteries"
    ],
    "gold_answer": "Medial arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03035",
    "question": "What is associated with Corneal neovascularization?",
    "seeds": [
      "Corneal neovascularization"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03036",
    "question": "What is associated with Meningitis?",
    "seeds": [
      "Meningitis"
    ],
    "gold_answer": "Unusual infection by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03037",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia, Aggrecan type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, Aggrecan type"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03038",
    "question": "What is associated with Curved phalanges of the hand?",
    "seeds": [
      "Curved phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03039",
    "question": "What is associated with Linear nevus sebaceus syndrome?",
    "seeds": [
      "Linear nevus sebaceus syndrome"
    ],
    "gold_answer": "Abnormal uvea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03040",
    "question": "What is associated with Fused sternal ossification centers?",
    "seeds": [
      "Fused sternal ossification centers"
    ],
    "gold_answer": "Abnormal sternal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03041",
    "question": "What is associated with Abnormal best corrected visual acuity test?",
    "seeds": [
      "Abnormal best corrected visual acuity test"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03042",
    "question": "What is associated with Decreased CSF 5-methyltetrahydrofolate concentration?",
    "seeds": [
      "Decreased CSF 5-methyltetrahydrofolate concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03043",
    "question": "What is associated with Aplasia of the vagina?",
    "seeds": [
      "Aplasia of the vagina"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the vagina",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03044",
    "question": "What is associated with Traction bronchiolectasis?",
    "seeds": [
      "Traction bronchiolectasis"
    ],
    "gold_answer": "Abnormal bronchus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03045",
    "question": "What is associated with Testicular seminoma?",
    "seeds": [
      "Testicular seminoma"
    ],
    "gold_answer": "Testicular neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03046",
    "question": "What phenotype is associated with Spinocerebellar ataxia 38?",
    "seeds": [
      "Spinocerebellar ataxia 38"
    ],
    "gold_answer": "Slow saccadic eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03047",
    "question": "What is associated with Multiple pterygia?",
    "seeds": [
      "Multiple pterygia"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03048",
    "question": "What is associated with 22q11.2 deletion syndrome?",
    "seeds": [
      "22q11.2 deletion syndrome"
    ],
    "gold_answer": "Duplication involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03049",
    "question": "What is associated with Spinal muscular atrophy, type III?",
    "seeds": [
      "Spinal muscular atrophy, type III"
    ],
    "gold_answer": "Fasciculations",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03050",
    "question": "What phenotype is associated with Non-progressive cerebellar ataxia with intellectual disability?",
    "seeds": [
      "Non-progressive cerebellar ataxia with intellectual disability"
    ],
    "gold_answer": "Short ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03051",
    "question": "What is associated with Abnormal level of lymph-node cellular CD19 expression?",
    "seeds": [
      "Abnormal level of lymph-node cellular CD19 expression"
    ],
    "gold_answer": "Abnormal lymph-node cellular B-cell marker expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03052",
    "question": "What phenotype is associated with 19q13.11 microdeletion syndrome?",
    "seeds": [
      "19q13.11 microdeletion syndrome"
    ],
    "gold_answer": "Sparse or absent eyelashes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03053",
    "question": "What is associated with Elevated circulating cholesterol sulfate concentration?",
    "seeds": [
      "Elevated circulating cholesterol sulfate concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03054",
    "question": "What is associated with Continuous spike and waves during slow sleep?",
    "seeds": [
      "Continuous spike and waves during slow sleep"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03055",
    "question": "What is associated with Myopathy, sarcoplasmic body?",
    "seeds": [
      "Myopathy, sarcoplasmic body"
    ],
    "gold_answer": "Abnormality of facial soft tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03056",
    "question": "What is associated with Compensated hypothyroidism?",
    "seeds": [
      "Compensated hypothyroidism"
    ],
    "gold_answer": "Hypothyroidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03057",
    "question": "What is associated with Bilateral acute depigmentation of the iris?",
    "seeds": [
      "Bilateral acute depigmentation of the iris"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03058",
    "question": "What is associated with Bloom syndrome?",
    "seeds": [
      "Bloom syndrome"
    ],
    "gold_answer": "Neoplasm of the stomach",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03059",
    "question": "What is associated with Splenic xanthomatosis?",
    "seeds": [
      "Splenic xanthomatosis"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03060",
    "question": "What is associated with Spondyloocular syndrome?",
    "seeds": [
      "Spondyloocular syndrome"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03061",
    "question": "What is associated with Recurrent infections due to specific granule deficiency?",
    "seeds": [
      "Recurrent infections due to specific granule deficiency"
    ],
    "gold_answer": "CEBPE",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_03062",
    "question": "What is associated with Congenital disorder of glycosylation, type IIB?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIB"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03063",
    "question": "What is associated with Salter IV fracture?",
    "seeds": [
      "Salter IV fracture"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03064",
    "question": "What is associated with Neurodevelopmental disorder with infantile epileptic spasms?",
    "seeds": [
      "Neurodevelopmental disorder with infantile epileptic spasms"
    ],
    "gold_answer": "Esodeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03065",
    "question": "What is associated with Elevated alkaline phosphatase of bone origin?",
    "seeds": [
      "Elevated alkaline phosphatase of bone origin"
    ],
    "gold_answer": "Abnormality of alkaline phosphatase level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03066",
    "question": "What is associated with Immunodeficiency 20?",
    "seeds": [
      "Immunodeficiency 20"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03067",
    "question": "What is associated with Reduced hepatic glyoxylate reductase activity?",
    "seeds": [
      "Reduced hepatic glyoxylate reductase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03068",
    "question": "What is associated with Dysplastic iliac wing?",
    "seeds": [
      "Dysplastic iliac wing"
    ],
    "gold_answer": "Abnormal hip bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03069",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 64?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 64"
    ],
    "gold_answer": "Hyperactivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03070",
    "question": "What phenotype is associated with Platelet factor 3 deficiency?",
    "seeds": [
      "Platelet factor 3 deficiency"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03071",
    "question": "What is associated with Bullet-shaped proximal phalanx of the 5th finger?",
    "seeds": [
      "Bullet-shaped proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03072",
    "question": "What is associated with Hyperplasia of the Leydig cells?",
    "seeds": [
      "Hyperplasia of the Leydig cells"
    ],
    "gold_answer": "Abnormality of the Leydig cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03073",
    "question": "What is associated with Femur, unilateral bifid, with monodactylous ectrodactyly?",
    "seeds": [
      "Femur, unilateral bifid, with monodactylous ectrodactyly"
    ],
    "gold_answer": "Abnormal tibia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03074",
    "question": "What is associated with Circulating immune complexes?",
    "seeds": [
      "Circulating immune complexes"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03075",
    "question": "What phenotype is associated with Relapsing polychondritis?",
    "seeds": [
      "Relapsing polychondritis"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03076",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03077",
    "question": "What is associated with Generalized morning stiffness?",
    "seeds": [
      "Generalized morning stiffness"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03078",
    "question": "What is associated with Decreased red blood cell count?",
    "seeds": [
      "Decreased red blood cell count"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03079",
    "question": "What is associated with Very preterm birth?",
    "seeds": [
      "Very preterm birth"
    ],
    "gold_answer": "Premature birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03080",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked syndromic, Raymond type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic, Raymond type"
    ],
    "gold_answer": "Arachnodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03081",
    "question": "What is associated with Ovarian thecoma?",
    "seeds": [
      "Ovarian thecoma"
    ],
    "gold_answer": "Ovarian sex cord-stromal tumor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03082",
    "question": "What is associated with Takotsubo cardiomyopathy?",
    "seeds": [
      "Takotsubo cardiomyopathy"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03083",
    "question": "What phenotype is associated with Cone dystrophy 3?",
    "seeds": [
      "Cone dystrophy 3"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03084",
    "question": "What is associated with Ear pain exacerbated by manipulating tragus or pinna?",
    "seeds": [
      "Ear pain exacerbated by manipulating tragus or pinna"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03085",
    "question": "What is associated with EPILEPSY-TELANGIECTASIA?",
    "seeds": [
      "EPILEPSY-TELANGIECTASIA"
    ],
    "gold_answer": "Facial hypertrichosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03086",
    "question": "What is associated with Abnormal infraorbital artery morphology?",
    "seeds": [
      "Abnormal infraorbital artery morphology"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03087",
    "question": "What is associated with Cystic hamartoma of lung and kidney?",
    "seeds": [
      "Cystic hamartoma of lung and kidney"
    ],
    "gold_answer": "Renal cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03088",
    "question": "What is associated with Gastrointestinal granulomatosis?",
    "seeds": [
      "Gastrointestinal granulomatosis"
    ],
    "gold_answer": "Abnormal macrophage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03089",
    "question": "What is associated with Pattern dystrophy of the retina?",
    "seeds": [
      "Pattern dystrophy of the retina"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03090",
    "question": "What is associated with Cortical diaphyseal thickening of the upper limbs?",
    "seeds": [
      "Cortical diaphyseal thickening of the upper limbs"
    ],
    "gold_answer": "Anomaly of the upper limb diaphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03091",
    "question": "What phenotype is associated with 8q12 microduplication syndrome?",
    "seeds": [
      "8q12 microduplication syndrome"
    ],
    "gold_answer": "Telecanthus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03092",
    "question": "What is associated with Objectification of others?",
    "seeds": [
      "Objectification of others"
    ],
    "gold_answer": "Abnormal social development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03093",
    "question": "What phenotype is associated with Cardiac rhabdoid tumor?",
    "seeds": [
      "Cardiac rhabdoid tumor"
    ],
    "gold_answer": "Internal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03094",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic 1?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic 1"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03095",
    "question": "What is associated with Extrapyramidal dyskinesia?",
    "seeds": [
      "Extrapyramidal dyskinesia"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03096",
    "question": "What is associated with Decreased pulmonary fissure count?",
    "seeds": [
      "Decreased pulmonary fissure count"
    ],
    "gold_answer": "Abnormal lung development",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03097",
    "question": "What is associated with Elevated circulating apolipoprotein C-III concentration?",
    "seeds": [
      "Elevated circulating apolipoprotein C-III concentration"
    ],
    "gold_answer": "Abnormal circulating apolipoprotein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03098",
    "question": "What is associated with Idiopathic acute eosinophilic pneumonia?",
    "seeds": [
      "Idiopathic acute eosinophilic pneumonia"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03099",
    "question": "What is associated with Spinal myoclonus?",
    "seeds": [
      "Spinal myoclonus"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03100",
    "question": "What is associated with Anti-U11/U12 RNP antibody positivity?",
    "seeds": [
      "Anti-U11/U12 RNP antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03101",
    "question": "What is associated with Spastic ataxia 3, autosomal recessive?",
    "seeds": [
      "Spastic ataxia 3, autosomal recessive"
    ],
    "gold_answer": "Abnormal cerebellar vermis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03102",
    "question": "What is associated with Agenesis of maxillary lateral incisor?",
    "seeds": [
      "Agenesis of maxillary lateral incisor"
    ],
    "gold_answer": "Agenesis of lateral incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03103",
    "question": "What is associated with Hemimacroglossia?",
    "seeds": [
      "Hemimacroglossia"
    ],
    "gold_answer": "Macroglossia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03104",
    "question": "What is associated with Atelencephaly?",
    "seeds": [
      "Atelencephaly"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03105",
    "question": "What is associated with Exencephaly?",
    "seeds": [
      "Exencephaly"
    ],
    "gold_answer": "Abnormal neural tube morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03106",
    "question": "What is associated with High axial triradius?",
    "seeds": [
      "High axial triradius"
    ],
    "gold_answer": "Abnormal skin morphology of the palm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03107",
    "question": "What phenotype is associated with Retinitis pigmentosa 63?",
    "seeds": [
      "Retinitis pigmentosa 63"
    ],
    "gold_answer": "Nyctalopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03108",
    "question": "What is associated with Gastrointestinal atresia?",
    "seeds": [
      "Gastrointestinal atresia"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03109",
    "question": "What is associated with Cardiac fibroma?",
    "seeds": [
      "Cardiac fibroma"
    ],
    "gold_answer": "Fibroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03110",
    "question": "What is associated with Hyperpyrexia?",
    "seeds": [
      "Hyperpyrexia"
    ],
    "gold_answer": "Fever",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03111",
    "question": "What is associated with Intellectual developmental disorder, X-linked, syndromic 32?",
    "seeds": [
      "Intellectual developmental disorder, X-linked, syndromic 32"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03112",
    "question": "What is associated with Multiple enchondromatosis?",
    "seeds": [
      "Multiple enchondromatosis"
    ],
    "gold_answer": "Neoplasm of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03113",
    "question": "What is associated with Rhomboid or triangular shaped 5th finger proximal phalanx?",
    "seeds": [
      "Rhomboid or triangular shaped 5th finger proximal phalanx"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03114",
    "question": "What is associated with Hydrolethalus syndrome 1?",
    "seeds": [
      "Hydrolethalus syndrome 1"
    ],
    "gold_answer": "Ventriculomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03115",
    "question": "What phenotype is associated with Radio-renal syndrome?",
    "seeds": [
      "Radio-renal syndrome"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03116",
    "question": "What is associated with Adenocarcinoma of the colon?",
    "seeds": [
      "Adenocarcinoma of the colon"
    ],
    "gold_answer": "Neoplasm of the colon",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03117",
    "question": "What is associated with Irregular epiphysis of the distal phalanx of the 4th finger?",
    "seeds": [
      "Irregular epiphysis of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the distal phalanx of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03118",
    "question": "What is associated with Idiopathic small fibers neuropathy?",
    "seeds": [
      "Idiopathic small fibers neuropathy"
    ],
    "gold_answer": "Akathisia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03119",
    "question": "What is associated with Focal impaired awareness motor seizure with paresis/paralysis?",
    "seeds": [
      "Focal impaired awareness motor seizure with paresis/paralysis"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03120",
    "question": "What phenotype is associated with Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome?",
    "seeds": [
      "Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome"
    ],
    "gold_answer": "Hypogonadotropic hypogonadism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03121",
    "question": "What is associated with Enlarged epiphyses of the 5th toe?",
    "seeds": [
      "Enlarged epiphyses of the 5th toe"
    ],
    "gold_answer": "Enlarged epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03122",
    "question": "What is associated with Elevated circulating Angiotensin-converting enzyme concentration?",
    "seeds": [
      "Elevated circulating Angiotensin-converting enzyme concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03123",
    "question": "What is associated with Abnormal third cranial nerve morphology?",
    "seeds": [
      "Abnormal third cranial nerve morphology"
    ],
    "gold_answer": "Abnormal cranial nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03124",
    "question": "What is associated with Triangular shaped middle phalanges of the hand?",
    "seeds": [
      "Triangular shaped middle phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03125",
    "question": "What phenotype is associated with SERKAL syndrome?",
    "seeds": [
      "SERKAL syndrome"
    ],
    "gold_answer": "Abnormality of the penis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03126",
    "question": "What is associated with Intestinal lymphangiectasia?",
    "seeds": [
      "Intestinal lymphangiectasia"
    ],
    "gold_answer": "Lymphangiectasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03127",
    "question": "What is associated with Duplication of phalanx of hallux?",
    "seeds": [
      "Duplication of phalanx of hallux"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03128",
    "question": "What phenotype is associated with Hereditary pheochromocytoma-paraganglioma?",
    "seeds": [
      "Hereditary pheochromocytoma-paraganglioma"
    ],
    "gold_answer": "Weight loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03129",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 80?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 80"
    ],
    "gold_answer": "Abnormal urine alpha-ketoglutarate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03130",
    "question": "What is associated with Central hypoventilation syndrome, congenital, 3?",
    "seeds": [
      "Central hypoventilation syndrome, congenital, 3"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03131",
    "question": "What is associated with Cortical radial artery hypercellularity?",
    "seeds": [
      "Cortical radial artery hypercellularity"
    ],
    "gold_answer": "Abnormal cortical radial artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03132",
    "question": "What is associated with Patchy sclerosis of the 1st metatarsal?",
    "seeds": [
      "Patchy sclerosis of the 1st metatarsal"
    ],
    "gold_answer": "Patchy sclerosis of hallux phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03133",
    "question": "What is associated with Positive bloodstream Cysticercosis antigen test?",
    "seeds": [
      "Positive bloodstream Cysticercosis antigen test"
    ],
    "gold_answer": "Positive bloodstream infectious agent antigen test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03134",
    "question": "What is associated with Autoimmune lymphoproliferative syndrome?",
    "seeds": [
      "Autoimmune lymphoproliferative syndrome"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03135",
    "question": "What is associated with Atrophy/Degeneration involving the caudate nucleus?",
    "seeds": [
      "Atrophy/Degeneration involving the caudate nucleus"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03136",
    "question": "What is associated with Vertical supranuclear gaze palsy?",
    "seeds": [
      "Vertical supranuclear gaze palsy"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03137",
    "question": "What is associated with Radial head fracture?",
    "seeds": [
      "Radial head fracture"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03138",
    "question": "What is associated with Abnormal number of hair whorls?",
    "seeds": [
      "Abnormal number of hair whorls"
    ],
    "gold_answer": "Abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03139",
    "question": "What phenotype is associated with Agammaglobulinemia, X-linked?",
    "seeds": [
      "Agammaglobulinemia, X-linked"
    ],
    "gold_answer": "Pyoderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03140",
    "question": "What is associated with Venular insufficiency, systemic?",
    "seeds": [
      "Venular insufficiency, systemic"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03141",
    "question": "What phenotype is associated with Ascites, chylous?",
    "seeds": [
      "Ascites, chylous"
    ],
    "gold_answer": "Chylous ascites",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03142",
    "question": "What is associated with Pancreatitis, hereditary?",
    "seeds": [
      "Pancreatitis, hereditary"
    ],
    "gold_answer": "Abnormality of temperature regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03143",
    "question": "What is associated with Mesangial microfibril deposition?",
    "seeds": [
      "Mesangial microfibril deposition"
    ],
    "gold_answer": "Mesangial fibril deposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03144",
    "question": "What phenotype is associated with Palmoplantar keratoderma, epidermolytic, 2?",
    "seeds": [
      "Palmoplantar keratoderma, epidermolytic, 2"
    ],
    "gold_answer": "Curly hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03145",
    "question": "What is associated with Increased sputum production?",
    "seeds": [
      "Increased sputum production"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03146",
    "question": "What is associated with Hereditary continuous muscle fiber activity?",
    "seeds": [
      "Hereditary continuous muscle fiber activity"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03147",
    "question": "What is associated with Abnormal eyelash morphology?",
    "seeds": [
      "Abnormal eyelash morphology"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03148",
    "question": "What is associated with Generalized ichthyosis?",
    "seeds": [
      "Generalized ichthyosis"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03149",
    "question": "What is associated with Anti-human immunodeficiency virus antibody positivity?",
    "seeds": [
      "Anti-human immunodeficiency virus antibody positivity"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03150",
    "question": "What phenotype is associated with Mitochondrial complex IV deficiency, nuclear type 15?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 15"
    ],
    "gold_answer": "Myoclonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03151",
    "question": "What is associated with Carpal synostosis?",
    "seeds": [
      "Carpal synostosis"
    ],
    "gold_answer": "Synostosis involving bones of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03152",
    "question": "What is associated with Increased anti-bacteria IgE antibody level?",
    "seeds": [
      "Increased anti-bacteria IgE antibody level"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03153",
    "question": "What is associated with Oculodentodigital dysplasia, autosomal recessive?",
    "seeds": [
      "Oculodentodigital dysplasia, autosomal recessive"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03154",
    "question": "What is associated with Titubation?",
    "seeds": [
      "Titubation"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03155",
    "question": "What is associated with Patellar dislocation?",
    "seeds": [
      "Patellar dislocation"
    ],
    "gold_answer": "Lower extremity joint dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03156",
    "question": "What is associated with Arteriovenous crossing sign?",
    "seeds": [
      "Arteriovenous crossing sign"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03157",
    "question": "What is associated with Finger swelling?",
    "seeds": [
      "Finger swelling"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03158",
    "question": "What is associated with Abnormal facial skeleton morphology?",
    "seeds": [
      "Abnormal facial skeleton morphology"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03159",
    "question": "What is associated with Prolonged N2 sleep?",
    "seeds": [
      "Prolonged N2 sleep"
    ],
    "gold_answer": "Prolonged NREM sleep",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03160",
    "question": "What is associated with Diminishment of relationship seeking?",
    "seeds": [
      "Diminishment of relationship seeking"
    ],
    "gold_answer": "Diminishment of social interactions",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03161",
    "question": "What is associated with Increased central memory CD8+ T cell proportion?",
    "seeds": [
      "Increased central memory CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal CD8+ T cell subset proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03162",
    "question": "What is associated with Hypoinsulinemic hypoglycemia and body hemihypertrophy?",
    "seeds": [
      "Hypoinsulinemic hypoglycemia and body hemihypertrophy"
    ],
    "gold_answer": "Abnormality of the tonsils",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03163",
    "question": "What phenotype is associated with Ring chromosome 19 syndrome?",
    "seeds": [
      "Ring chromosome 19 syndrome"
    ],
    "gold_answer": "Talipes equinovarus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03164",
    "question": "What is associated with Sacral agenesis with vertebral anomalies?",
    "seeds": [
      "Sacral agenesis with vertebral anomalies"
    ],
    "gold_answer": "Cloacal abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03165",
    "question": "What is associated with Multiple impacted teeth?",
    "seeds": [
      "Multiple impacted teeth"
    ],
    "gold_answer": "Eruption failure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03166",
    "question": "What is associated with Elfin facies?",
    "seeds": [
      "Elfin facies"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03167",
    "question": "What is associated with Hypercystinemia?",
    "seeds": [
      "Hypercystinemia"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03168",
    "question": "What is associated with Pulmonary necrosis?",
    "seeds": [
      "Pulmonary necrosis"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03169",
    "question": "What phenotype is associated with Syndactyly type 5?",
    "seeds": [
      "Syndactyly type 5"
    ],
    "gold_answer": "Camptodactyly of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03170",
    "question": "What phenotype is associated with Bone pain, periodic?",
    "seeds": [
      "Bone pain, periodic"
    ],
    "gold_answer": "Bone pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03171",
    "question": "What is associated with Lipoid congenital adrenal hyperplasia?",
    "seeds": [
      "Lipoid congenital adrenal hyperplasia"
    ],
    "gold_answer": "Abnormality of the urethra",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03172",
    "question": "What is associated with Reduced lymphocyte surface expression of CD43?",
    "seeds": [
      "Reduced lymphocyte surface expression of CD43"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03173",
    "question": "What phenotype is associated with Symphalangism, c. s. Lewis type?",
    "seeds": [
      "Symphalangism, c. s. Lewis type"
    ],
    "gold_answer": "Synostosis involving the 1st metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03174",
    "question": "What is associated with Deafness, autosomal dominant 36?",
    "seeds": [
      "Deafness, autosomal dominant 36"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03175",
    "question": "What is associated with Congenital isolated ACTH deficiency?",
    "seeds": [
      "Congenital isolated ACTH deficiency"
    ],
    "gold_answer": "Cholestasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03176",
    "question": "What phenotype is associated with Coffin-Siris syndrome 2?",
    "seeds": [
      "Coffin-Siris syndrome 2"
    ],
    "gold_answer": "Thick vermilion border",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03177",
    "question": "What is associated with Lytic defects of radial diaphysis?",
    "seeds": [
      "Lytic defects of radial diaphysis"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03178",
    "question": "What is associated with Distributed along skin tension lines?",
    "seeds": [
      "Distributed along skin tension lines"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03179",
    "question": "What is associated with Retinal degeneration and epilepsy?",
    "seeds": [
      "Retinal degeneration and epilepsy"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03180",
    "question": "What phenotype is associated with Atelosteogenesis, type I?",
    "seeds": [
      "Atelosteogenesis, type I"
    ],
    "gold_answer": "Disproportionate short-limb short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03181",
    "question": "What is associated with Abnormal atrioventricular valve morphology?",
    "seeds": [
      "Abnormal atrioventricular valve morphology"
    ],
    "gold_answer": "Abnormal heart valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03182",
    "question": "What is associated with Joubert syndrome 7?",
    "seeds": [
      "Joubert syndrome 7"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03183",
    "question": "What phenotype is associated with Dermatitis, atopic?",
    "seeds": [
      "Dermatitis, atopic"
    ],
    "gold_answer": "Facial erythema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03184",
    "question": "What is associated with Increased fecal protoporphyrin concentration?",
    "seeds": [
      "Increased fecal protoporphyrin concentration"
    ],
    "gold_answer": "Abnormal stool composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03185",
    "question": "What is associated with Elevated circulating methylglutarylcarnitine concentration?",
    "seeds": [
      "Elevated circulating methylglutarylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03186",
    "question": "What is associated with Arcuate vein medial hypertrophy?",
    "seeds": [
      "Arcuate vein medial hypertrophy"
    ],
    "gold_answer": "Abnormal arcuate vein intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03187",
    "question": "What is associated with Temple syndrome due to paternal 14q32.2 hypomethylation?",
    "seeds": [
      "Temple syndrome due to paternal 14q32.2 hypomethylation"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03188",
    "question": "What is associated with Early onset absence seizures?",
    "seeds": [
      "Early onset absence seizures"
    ],
    "gold_answer": "Generalized-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03189",
    "question": "What is associated with Pulmonary air embolism?",
    "seeds": [
      "Pulmonary air embolism"
    ],
    "gold_answer": "Pulmonary embolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03190",
    "question": "What phenotype is associated with Thrombophilia due to thrombomodulin defect?",
    "seeds": [
      "Thrombophilia due to thrombomodulin defect"
    ],
    "gold_answer": "Hypercoagulability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03191",
    "question": "What is associated with Increased level of galactitol in urine?",
    "seeds": [
      "Increased level of galactitol in urine"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03192",
    "question": "What is associated with Optic nerve hypoplasia?",
    "seeds": [
      "Optic nerve hypoplasia"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03193",
    "question": "What phenotype is associated with Sorbitol dehydrogenase deficiency with peripheral neuropathy?",
    "seeds": [
      "Sorbitol dehydrogenase deficiency with peripheral neuropathy"
    ],
    "gold_answer": "Increased serum sorbitol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03194",
    "question": "What is associated with Cutaneous collagenous vasculopathy?",
    "seeds": [
      "Cutaneous collagenous vasculopathy"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03195",
    "question": "What is associated with Tibialis muscle weakness?",
    "seeds": [
      "Tibialis muscle weakness"
    ],
    "gold_answer": "Distal lower limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03196",
    "question": "What is associated with Axenfeld-Rieger syndrome, type 1?",
    "seeds": [
      "Axenfeld-Rieger syndrome, type 1"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the fovea",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03197",
    "question": "What is associated with Lacrimal duct aplasia?",
    "seeds": [
      "Lacrimal duct aplasia"
    ],
    "gold_answer": "Abnormal nasolacrimal system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03198",
    "question": "What is associated with Lymphoblastic leukemia, acute, with lymphomatous features?",
    "seeds": [
      "Lymphoblastic leukemia, acute, with lymphomatous features"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03199",
    "question": "What is associated with Elevated tissue non-specific alkaline phosphatase?",
    "seeds": [
      "Elevated tissue non-specific alkaline phosphatase"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03200",
    "question": "What is associated with Enlarged epiphyses of the 4th finger?",
    "seeds": [
      "Enlarged epiphyses of the 4th finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03201",
    "question": "What is associated with Myopathy, centronuclear, 6, with fiber-type disproportion?",
    "seeds": [
      "Myopathy, centronuclear, 6, with fiber-type disproportion"
    ],
    "gold_answer": "Ankle contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03202",
    "question": "What is associated with Hypoglossia with situs inversus?",
    "seeds": [
      "Hypoglossia with situs inversus"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03203",
    "question": "What is associated with Decreased circulating antidiuretic hormone concentration?",
    "seeds": [
      "Decreased circulating antidiuretic hormone concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03204",
    "question": "What is associated with Narcolepsy 1?",
    "seeds": [
      "Narcolepsy 1"
    ],
    "gold_answer": "Parasomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03205",
    "question": "What is associated with Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome?",
    "seeds": [
      "Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03206",
    "question": "What is associated with Delayed femoral head ossification?",
    "seeds": [
      "Delayed femoral head ossification"
    ],
    "gold_answer": "Abnormal enchondral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03207",
    "question": "What is associated with Criss-cross heart?",
    "seeds": [
      "Criss-cross heart"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03208",
    "question": "What phenotype is associated with Tooth malformation?",
    "seeds": [
      "Tooth malformation"
    ],
    "gold_answer": "Tooth malposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03209",
    "question": "What is associated with Epidermolysis bullosa simplex 1D, generalized, intermediate or severe, autosomal recessive?",
    "seeds": [
      "Epidermolysis bullosa simplex 1D, generalized, intermediate or severe, autosomal recessive"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03210",
    "question": "What is associated with Anterior rounding of vertebral bodies?",
    "seeds": [
      "Anterior rounding of vertebral bodies"
    ],
    "gold_answer": "Ovoid vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03211",
    "question": "What is associated with Muscle hyperirritability?",
    "seeds": [
      "Muscle hyperirritability"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03212",
    "question": "What is associated with Hypoplastic anemia?",
    "seeds": [
      "Hypoplastic anemia"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03213",
    "question": "What phenotype is associated with Peroxisomal acyl-CoA oxidase deficiency?",
    "seeds": [
      "Peroxisomal acyl-CoA oxidase deficiency"
    ],
    "gold_answer": "Babinski sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03214",
    "question": "What is associated with Anoperineal fistula?",
    "seeds": [
      "Anoperineal fistula"
    ],
    "gold_answer": "Anal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03215",
    "question": "What is associated with Increased unswitched memory B cell proportion?",
    "seeds": [
      "Increased unswitched memory B cell proportion"
    ],
    "gold_answer": "Abnormal memory B cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03216",
    "question": "What is associated with Irregular chondrocostal junctions?",
    "seeds": [
      "Irregular chondrocostal junctions"
    ],
    "gold_answer": "Abnormality of the costochondral junction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03217",
    "question": "What is associated with Sandestig-Stefanova syndrome?",
    "seeds": [
      "Sandestig-Stefanova syndrome"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03218",
    "question": "What is associated with Hemihypertrophy?",
    "seeds": [
      "Hemihypertrophy"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03219",
    "question": "What is associated with Moderate myopia?",
    "seeds": [
      "Moderate myopia"
    ],
    "gold_answer": "Myopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03220",
    "question": "What is associated with Abnormal nasolacrimal system morphology?",
    "seeds": [
      "Abnormal nasolacrimal system morphology"
    ],
    "gold_answer": "Abnormality of the orbital region",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03221",
    "question": "What is associated with Severe combined immunodeficiency due to DCLRE1C deficiency?",
    "seeds": [
      "Severe combined immunodeficiency due to DCLRE1C deficiency"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03222",
    "question": "What is associated with Macrocytic dyserythropoietic anemia?",
    "seeds": [
      "Macrocytic dyserythropoietic anemia"
    ],
    "gold_answer": "Macrocytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03223",
    "question": "What phenotype is associated with Chilblain lupus?",
    "seeds": [
      "Chilblain lupus"
    ],
    "gold_answer": "Rheumatoid factor positive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03224",
    "question": "What is associated with Abnormal circulating interleukin 6 concentration?",
    "seeds": [
      "Abnormal circulating interleukin 6 concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03225",
    "question": "What is associated with Glomerular hyaline subepithelial deposits?",
    "seeds": [
      "Glomerular hyaline subepithelial deposits"
    ],
    "gold_answer": "Glomerular deposits",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03226",
    "question": "What is associated with Exposure to repetitive hand impact?",
    "seeds": [
      "Exposure to repetitive hand impact"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03227",
    "question": "What is associated with Aortic smooth muscle cell nuclei loss?",
    "seeds": [
      "Aortic smooth muscle cell nuclei loss"
    ],
    "gold_answer": "Medial degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03228",
    "question": "What is associated with Fractured middle phalanx of finger?",
    "seeds": [
      "Fractured middle phalanx of finger"
    ],
    "gold_answer": "Abnormal middle phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03229",
    "question": "What is associated with Absent bronchoalveolar dimeric surfactant-protein B?",
    "seeds": [
      "Absent bronchoalveolar dimeric surfactant-protein B"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03230",
    "question": "What is associated with Mildly reduced contrast sensitivity?",
    "seeds": [
      "Mildly reduced contrast sensitivity"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03231",
    "question": "What is associated with Clubbing of fingers?",
    "seeds": [
      "Clubbing of fingers"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03232",
    "question": "What is associated with Anti-contactin-1 antibody positivity?",
    "seeds": [
      "Anti-contactin-1 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03233",
    "question": "What is associated with Pyknoachondrogenesis?",
    "seeds": [
      "Pyknoachondrogenesis"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03234",
    "question": "What is associated with Abnormal Z disk morphology?",
    "seeds": [
      "Abnormal Z disk morphology"
    ],
    "gold_answer": "Abnormal sarcomere morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03235",
    "question": "What is associated with Increased circulating purine concentration?",
    "seeds": [
      "Increased circulating purine concentration"
    ],
    "gold_answer": "Abnormal circulating purine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03236",
    "question": "What is associated with Tangier disease?",
    "seeds": [
      "Tangier disease"
    ],
    "gold_answer": "Arteriosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03237",
    "question": "What phenotype is associated with Parkinson disease 23, autosomal recessive, early onset?",
    "seeds": [
      "Parkinson disease 23, autosomal recessive, early onset"
    ],
    "gold_answer": "Neuronal loss in central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03238",
    "question": "What is associated with Familial cold urticaria?",
    "seeds": [
      "Familial cold urticaria"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03239",
    "question": "What is associated with Corneal perforation?",
    "seeds": [
      "Corneal perforation"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03240",
    "question": "What phenotype is associated with Microcornea-posterior megalolenticonus-persistent fetal vasculature-coloboma syndrome?",
    "seeds": [
      "Microcornea-posterior megalolenticonus-persistent fetal vasculature-coloboma syndrome"
    ],
    "gold_answer": "Microcornea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03241",
    "question": "What is associated with Infantile-onset autosomal recessive nonprogressive cerebellar ataxia?",
    "seeds": [
      "Infantile-onset autosomal recessive nonprogressive cerebellar ataxia"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03242",
    "question": "What phenotype is associated with Spinal muscular atrophy, distal, autosomal recessive, 2?",
    "seeds": [
      "Spinal muscular atrophy, distal, autosomal recessive, 2"
    ],
    "gold_answer": "Pes cavus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03243",
    "question": "What is associated with Microcephaly-cervical spine fusion anomalies syndrome?",
    "seeds": [
      "Microcephaly-cervical spine fusion anomalies syndrome"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03244",
    "question": "What is associated with Epidermolysis bullosa simplex 2A, generalized severe?",
    "seeds": [
      "Epidermolysis bullosa simplex 2A, generalized severe"
    ],
    "gold_answer": "Blistering by anatomical location",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03245",
    "question": "What is associated with Lack of insight?",
    "seeds": [
      "Lack of insight"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03246",
    "question": "What is associated with Partial absence of specific antibody response to tetanus vaccine?",
    "seeds": [
      "Partial absence of specific antibody response to tetanus vaccine"
    ],
    "gold_answer": "Decreased specific antibody response to protein vaccine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03247",
    "question": "What is associated with Blepharocheilodontic syndrome 2?",
    "seeds": [
      "Blepharocheilodontic syndrome 2"
    ],
    "gold_answer": "Ectropion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03248",
    "question": "What is associated with Pulmonary tuberculosis?",
    "seeds": [
      "Pulmonary tuberculosis"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03249",
    "question": "What is associated with Mitochondrial complex IV deficiency, nuclear type 11?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 11"
    ],
    "gold_answer": "Chorea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03250",
    "question": "What is associated with Premature aging syndrome, Penttinen type?",
    "seeds": [
      "Premature aging syndrome, Penttinen type"
    ],
    "gold_answer": "Macular dots",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03251",
    "question": "What is associated with Abnormal fetal morphology?",
    "seeds": [
      "Abnormal fetal morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03252",
    "question": "What is associated with Decreased circulating fetuin A concentration?",
    "seeds": [
      "Decreased circulating fetuin A concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03253",
    "question": "What is associated with Tapered distal phalanges of finger?",
    "seeds": [
      "Tapered distal phalanges of finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03254",
    "question": "What is associated with Superior rectus muscle restriction?",
    "seeds": [
      "Superior rectus muscle restriction"
    ],
    "gold_answer": "Abnormal superior rectus muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03255",
    "question": "What is associated with Increased male libido?",
    "seeds": [
      "Increased male libido"
    ],
    "gold_answer": "Increased libido",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03256",
    "question": "What is associated with Epilepsy, familial temporal lobe, 5?",
    "seeds": [
      "Epilepsy, familial temporal lobe, 5"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03257",
    "question": "What is associated with Abnormal lymphocyte proliferation?",
    "seeds": [
      "Abnormal lymphocyte proliferation"
    ],
    "gold_answer": "Abnormal cell proliferation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03258",
    "question": "What is associated with Trichomegaly-retina pigmentary degeneration-dwarfism syndrome?",
    "seeds": [
      "Trichomegaly-retina pigmentary degeneration-dwarfism syndrome"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03259",
    "question": "What is associated with Sleep apnea?",
    "seeds": [
      "Sleep apnea"
    ],
    "gold_answer": "Sleep-related breathing disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03260",
    "question": "What is associated with Immunodeficiency 44?",
    "seeds": [
      "Immunodeficiency 44"
    ],
    "gold_answer": "Decreased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03261",
    "question": "What is associated with Pulp obliteration?",
    "seeds": [
      "Pulp obliteration"
    ],
    "gold_answer": "Abnormal dental pulp morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03262",
    "question": "What is associated with Sonographic non-visualized fetal bladder?",
    "seeds": [
      "Sonographic non-visualized fetal bladder"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03263",
    "question": "What is associated with Elevated circulating sCD25 concentration?",
    "seeds": [
      "Elevated circulating sCD25 concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03264",
    "question": "What is associated with Deafness, autosomal dominant 89?",
    "seeds": [
      "Deafness, autosomal dominant 89"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03265",
    "question": "What is associated with Fractured proximal phalanx of digit 3?",
    "seeds": [
      "Fractured proximal phalanx of digit 3"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03266",
    "question": "What is associated with Finger joint contracture?",
    "seeds": [
      "Finger joint contracture"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03267",
    "question": "What is associated with Congenital erythropoietic porphyria?",
    "seeds": [
      "Congenital erythropoietic porphyria"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03268",
    "question": "What is associated with Macular dystrophy, vitelliform, 4?",
    "seeds": [
      "Macular dystrophy, vitelliform, 4"
    ],
    "gold_answer": "Yellow/white macular lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03269",
    "question": "What is associated with Derealization?",
    "seeds": [
      "Derealization"
    ],
    "gold_answer": "Abnormal perceptual state",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03270",
    "question": "What is associated with Foot mass?",
    "seeds": [
      "Foot mass"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03271",
    "question": "What is associated with Reduced alpha-aminoadipic semialdehyde synthase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced alpha-aminoadipic semialdehyde synthase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03272",
    "question": "What is associated with Felty syndrome?",
    "seeds": [
      "Felty syndrome"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03273",
    "question": "What is associated with Prognathism, mandibular?",
    "seeds": [
      "Prognathism, mandibular"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03274",
    "question": "What is associated with Deafness, autosomal recessive 113?",
    "seeds": [
      "Deafness, autosomal recessive 113"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03275",
    "question": "What is associated with Abnormal tricuspid chordae tendinae morphology?",
    "seeds": [
      "Abnormal tricuspid chordae tendinae morphology"
    ],
    "gold_answer": "Abnormal tricuspid valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03276",
    "question": "What is associated with Complement factor H deficiency?",
    "seeds": [
      "Complement factor H deficiency"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03277",
    "question": "What is associated with HANAC syndrome?",
    "seeds": [
      "HANAC syndrome"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03278",
    "question": "What is associated with Brachioradialis areflexia?",
    "seeds": [
      "Brachioradialis areflexia"
    ],
    "gold_answer": "Areflexia of upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03279",
    "question": "What is associated with Neoplasm of the adrenal cortex?",
    "seeds": [
      "Neoplasm of the adrenal cortex"
    ],
    "gold_answer": "Neoplasm of the adrenal gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03280",
    "question": "What is associated with Yellow skin plaque?",
    "seeds": [
      "Yellow skin plaque"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03281",
    "question": "What is associated with Brain dopamine-serotonin vesicular transport disease?",
    "seeds": [
      "Brain dopamine-serotonin vesicular transport disease"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03282",
    "question": "What phenotype is associated with Radio-Tartaglia syndrome?",
    "seeds": [
      "Radio-Tartaglia syndrome"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03283",
    "question": "What is associated with Developmental retinal vascular malformation?",
    "seeds": [
      "Developmental retinal vascular malformation"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03284",
    "question": "What phenotype is associated with Abcd syndrome?",
    "seeds": [
      "Abcd syndrome"
    ],
    "gold_answer": "White eyebrow",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03285",
    "question": "What is associated with 16p13.11 microdeletion syndrome?",
    "seeds": [
      "16p13.11 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal lung development",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03286",
    "question": "What is associated with Pseudoepiphysis of the middle phalanx of the 5th toe?",
    "seeds": [
      "Pseudoepiphysis of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Pseudoepiphyses of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03287",
    "question": "What is associated with Facioscapulohumeral dystrophy?",
    "seeds": [
      "Facioscapulohumeral dystrophy"
    ],
    "gold_answer": "Lagophthalmos",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03288",
    "question": "What is associated with Burning eye sensation?",
    "seeds": [
      "Burning eye sensation"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03289",
    "question": "What phenotype is associated with Warsaw breakage syndrome?",
    "seeds": [
      "Warsaw breakage syndrome"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03290",
    "question": "What phenotype is associated with Reese retinal dysplasia?",
    "seeds": [
      "Reese retinal dysplasia"
    ],
    "gold_answer": "Retinal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03291",
    "question": "What is associated with Prolinuria?",
    "seeds": [
      "Prolinuria"
    ],
    "gold_answer": "Increased proteinogenic amino acid level in urine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03292",
    "question": "What is associated with Salter V fracture?",
    "seeds": [
      "Salter V fracture"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03293",
    "question": "What is associated with Blau syndrome?",
    "seeds": [
      "Blau syndrome"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03294",
    "question": "What is associated with Hydatidiform mole?",
    "seeds": [
      "Hydatidiform mole"
    ],
    "gold_answer": "Abnormal platelet count",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03295",
    "question": "What is associated with Amelo-onycho-hypohidrotic syndrome?",
    "seeds": [
      "Amelo-onycho-hypohidrotic syndrome"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03296",
    "question": "What is associated with Conjunctival icterus?",
    "seeds": [
      "Conjunctival icterus"
    ],
    "gold_answer": "Abnormal conjunctiva morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03297",
    "question": "What phenotype is associated with Ataxia-hypogonadism-choroidal dystrophy syndrome?",
    "seeds": [
      "Ataxia-hypogonadism-choroidal dystrophy syndrome"
    ],
    "gold_answer": "Chorioretinal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03298",
    "question": "What is associated with Abnormal shoulder morphology?",
    "seeds": [
      "Abnormal shoulder morphology"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03299",
    "question": "What is associated with Lung fibroma?",
    "seeds": [
      "Lung fibroma"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03300",
    "question": "What is associated with Anti-babesia-specific antibody positivity?",
    "seeds": [
      "Anti-babesia-specific antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03301",
    "question": "What is associated with Multifocal neonatal sequential seizure?",
    "seeds": [
      "Multifocal neonatal sequential seizure"
    ],
    "gold_answer": "Neonatal seizure with electrographic correlate",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03302",
    "question": "What is associated with Anal mucosal leukoplakia?",
    "seeds": [
      "Anal mucosal leukoplakia"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03303",
    "question": "What is associated with Ivory epiphysis of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Ivory epiphysis of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03304",
    "question": "What is associated with Calcium oxalate nephrolithiasis?",
    "seeds": [
      "Calcium oxalate nephrolithiasis"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03305",
    "question": "What is associated with Inguinal abscess?",
    "seeds": [
      "Inguinal abscess"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03306",
    "question": "What is associated with Gallbladder enlargement?",
    "seeds": [
      "Gallbladder enlargement"
    ],
    "gold_answer": "Abnormal gallbladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03307",
    "question": "What is associated with Vascular Ehlers-Danlos syndrome?",
    "seeds": [
      "Vascular Ehlers-Danlos syndrome"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03308",
    "question": "What phenotype is associated with Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome?",
    "seeds": [
      "Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome"
    ],
    "gold_answer": "Barrett esophagus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03309",
    "question": "What is associated with Limb duplication?",
    "seeds": [
      "Limb duplication"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03310",
    "question": "What phenotype is associated with Brachycephaly, trichomegaly, and developmental delay?",
    "seeds": [
      "Brachycephaly, trichomegaly, and developmental delay"
    ],
    "gold_answer": "Thin vermilion border",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03311",
    "question": "What is associated with Retinal calcification?",
    "seeds": [
      "Retinal calcification"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03312",
    "question": "What phenotype is associated with Atypical neurofibromatosis?",
    "seeds": [
      "Atypical neurofibromatosis"
    ],
    "gold_answer": "Spinal canal stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03313",
    "question": "What is associated with Nevus comedonicus?",
    "seeds": [
      "Nevus comedonicus"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03314",
    "question": "What is associated with Cerebrooculofacioskeletal syndrome 1?",
    "seeds": [
      "Cerebrooculofacioskeletal syndrome 1"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03315",
    "question": "What phenotype is associated with Short-Rib thoracic dysplasia 7 with or without polydactyly?",
    "seeds": [
      "Short-Rib thoracic dysplasia 7 with or without polydactyly"
    ],
    "gold_answer": "Flat acetabular roof",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03316",
    "question": "What is associated with Cervical agenesis?",
    "seeds": [
      "Cervical agenesis"
    ],
    "gold_answer": "Abnormality of the uterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03317",
    "question": "What is associated with Angiokeratoma circumscriptum naeviforme?",
    "seeds": [
      "Angiokeratoma circumscriptum naeviforme"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03318",
    "question": "What is associated with Retrocorneal membrane?",
    "seeds": [
      "Retrocorneal membrane"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03319",
    "question": "What phenotype is associated with Corneal dystrophy-perceptive deafness syndrome?",
    "seeds": [
      "Corneal dystrophy-perceptive deafness syndrome"
    ],
    "gold_answer": "Corneal opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03320",
    "question": "What is associated with Spina bifida occulta at L5?",
    "seeds": [
      "Spina bifida occulta at L5"
    ],
    "gold_answer": "Spina bifida",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03321",
    "question": "What is associated with Curved distal phalanx of the 5th toe?",
    "seeds": [
      "Curved distal phalanx of the 5th toe"
    ],
    "gold_answer": "Curved toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03322",
    "question": "What is associated with Adverse drug response?",
    "seeds": [
      "Adverse drug response"
    ],
    "gold_answer": "Abnormal drug response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03323",
    "question": "What is associated with Spastic paraplegia 44, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 44, autosomal recessive"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03324",
    "question": "What is associated with Renal interstitial necrotizing granulomas?",
    "seeds": [
      "Renal interstitial necrotizing granulomas"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03325",
    "question": "What is associated with Delayed puberty?",
    "seeds": [
      "Delayed puberty"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03326",
    "question": "What is associated with Neoplasm of the rectum?",
    "seeds": [
      "Neoplasm of the rectum"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03327",
    "question": "What is associated with Penile corporal blood gas ischemia?",
    "seeds": [
      "Penile corporal blood gas ischemia"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03328",
    "question": "What is associated with Osteolysis involving tarsal bones?",
    "seeds": [
      "Osteolysis involving tarsal bones"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03329",
    "question": "What is associated with Intellectual developmental disorder, X-linked 50?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 50"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03330",
    "question": "What is associated with Impaired visually enhanced vestibulo-ocular reflex?",
    "seeds": [
      "Impaired visually enhanced vestibulo-ocular reflex"
    ],
    "gold_answer": "Abnormal vestibulo-ocular reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03331",
    "question": "What phenotype is associated with Cataract 7?",
    "seeds": [
      "Cataract 7"
    ],
    "gold_answer": "Developmental cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03332",
    "question": "What phenotype is associated with Mitochondrial DNA depletion syndrome 17?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 17"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03333",
    "question": "What is associated with Dysplastic iliac wing?",
    "seeds": [
      "Dysplastic iliac wing"
    ],
    "gold_answer": "Abnormal iliac wing morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03334",
    "question": "What is associated with Reduced tissue alpha-N-acetylgalactosaminidase activity?",
    "seeds": [
      "Reduced tissue alpha-N-acetylgalactosaminidase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03335",
    "question": "What is associated with Lowe-Kohn-Cohen syndrome?",
    "seeds": [
      "Lowe-Kohn-Cohen syndrome"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03336",
    "question": "What is associated with Tarsal-carpal coalition syndrome?",
    "seeds": [
      "Tarsal-carpal coalition syndrome"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03337",
    "question": "What phenotype is associated with Noonan syndrome 13?",
    "seeds": [
      "Noonan syndrome 13"
    ],
    "gold_answer": "Head-banging",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03338",
    "question": "What is associated with Elevated right atrial pressure?",
    "seeds": [
      "Elevated right atrial pressure"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03339",
    "question": "What is associated with Autosomal dominant hyperinsulinism due to SUR1 deficiency?",
    "seeds": [
      "Autosomal dominant hyperinsulinism due to SUR1 deficiency"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03340",
    "question": "What phenotype is associated with Lipodystrophy, congenital generalized, type 4?",
    "seeds": [
      "Lipodystrophy, congenital generalized, type 4"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03341",
    "question": "What phenotype is associated with Ring chromosome 22 syndrome?",
    "seeds": [
      "Ring chromosome 22 syndrome"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03342",
    "question": "What phenotype is associated with Geleophysic dysplasia 2?",
    "seeds": [
      "Geleophysic dysplasia 2"
    ],
    "gold_answer": "Respiratory insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03343",
    "question": "What phenotype is associated with Proximal second finger symphalangism?",
    "seeds": [
      "Proximal second finger symphalangism"
    ],
    "gold_answer": "Metacarpophalangeal synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03344",
    "question": "What phenotype is associated with Short stature and microcephaly with genital anomalies?",
    "seeds": [
      "Short stature and microcephaly with genital anomalies"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03345",
    "question": "What is associated with Wieacker-Wolff syndrome, female-restricted?",
    "seeds": [
      "Wieacker-Wolff syndrome, female-restricted"
    ],
    "gold_answer": "Prenatal movement abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03346",
    "question": "What phenotype is associated with Camptodactyly syndrome, Guadalajara type 1?",
    "seeds": [
      "Camptodactyly syndrome, Guadalajara type 1"
    ],
    "gold_answer": "High palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03347",
    "question": "What is associated with Fanconi anemia, complementation group T?",
    "seeds": [
      "Fanconi anemia, complementation group T"
    ],
    "gold_answer": "Short finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03348",
    "question": "What is associated with Flared femoral metaphysis?",
    "seeds": [
      "Flared femoral metaphysis"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03349",
    "question": "What is associated with Hypouricemia?",
    "seeds": [
      "Hypouricemia"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03350",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Sclerosis of proximal phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03351",
    "question": "What is associated with Beta-thalassemia-X-linked thrombocytopenia syndrome?",
    "seeds": [
      "Beta-thalassemia-X-linked thrombocytopenia syndrome"
    ],
    "gold_answer": "Abnormal platelet count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03352",
    "question": "What is associated with Sneeze?",
    "seeds": [
      "Sneeze"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03353",
    "question": "What is associated with Wild type ATTR amyloidosis?",
    "seeds": [
      "Wild type ATTR amyloidosis"
    ],
    "gold_answer": "Impaired continence",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03354",
    "question": "What is associated with Elevated circulating S-sulfocysteine concentration?",
    "seeds": [
      "Elevated circulating S-sulfocysteine concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03355",
    "question": "What is associated with Delayed elbow epiphyseal ossification?",
    "seeds": [
      "Delayed elbow epiphyseal ossification"
    ],
    "gold_answer": "Abnormal epiphyseal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03356",
    "question": "What is associated with Pancreatitis?",
    "seeds": [
      "Pancreatitis"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03357",
    "question": "What is associated with Bicuspid aortic valve with right-noncoronary cusp fusion?",
    "seeds": [
      "Bicuspid aortic valve with right-noncoronary cusp fusion"
    ],
    "gold_answer": "Bicuspid aortic valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03358",
    "question": "What is associated with Myopathy, tubular aggregate, 1?",
    "seeds": [
      "Myopathy, tubular aggregate, 1"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03359",
    "question": "What is associated with Ectopic lacrimal punctum?",
    "seeds": [
      "Ectopic lacrimal punctum"
    ],
    "gold_answer": "Abnormal lacrimal punctum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03360",
    "question": "What is associated with Acute monoblastic/monocytic leukemia?",
    "seeds": [
      "Acute monoblastic/monocytic leukemia"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03361",
    "question": "What is associated with Increased urinary renal tubular epithelial cell count?",
    "seeds": [
      "Increased urinary renal tubular epithelial cell count"
    ],
    "gold_answer": "Abnormal urine cytology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03362",
    "question": "What phenotype is associated with Alobar holoprosencephaly?",
    "seeds": [
      "Alobar holoprosencephaly"
    ],
    "gold_answer": "Impaired visuospatial constructive cognition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03363",
    "question": "What is associated with Transient hypogammaglobulinemia of infancy?",
    "seeds": [
      "Transient hypogammaglobulinemia of infancy"
    ],
    "gold_answer": "Decreased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03364",
    "question": "What is associated with Pectus carinatum?",
    "seeds": [
      "Pectus carinatum"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03365",
    "question": "What is associated with Abnormal protein N-linked glycosylation?",
    "seeds": [
      "Abnormal protein N-linked glycosylation"
    ],
    "gold_answer": "Abnormal glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03366",
    "question": "What is associated with Bronchial diverticula?",
    "seeds": [
      "Bronchial diverticula"
    ],
    "gold_answer": "Abnormal bronchus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03367",
    "question": "What is associated with Decreased fetal abdominal circumference?",
    "seeds": [
      "Decreased fetal abdominal circumference"
    ],
    "gold_answer": "Abnormal fetal abdominal circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03368",
    "question": "What is associated with Rounded epiphyses?",
    "seeds": [
      "Rounded epiphyses"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03369",
    "question": "What is associated with Hypolipidemia?",
    "seeds": [
      "Hypolipidemia"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03370",
    "question": "What is associated with Anti-beta-2-Glycoprotein I IgM antibody positivity?",
    "seeds": [
      "Anti-beta-2-Glycoprotein I IgM antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03371",
    "question": "What is associated with Abnormal upper limb bone morphology?",
    "seeds": [
      "Abnormal upper limb bone morphology"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03372",
    "question": "What is associated with Isolated complex I deficiency?",
    "seeds": [
      "Isolated complex I deficiency"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03373",
    "question": "What phenotype is associated with Hereditary hemorrhagic telangiectasia?",
    "seeds": [
      "Hereditary hemorrhagic telangiectasia"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03374",
    "question": "What is associated with Widely patent sagittal suture?",
    "seeds": [
      "Widely patent sagittal suture"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03375",
    "question": "What phenotype is associated with Hereditary breast and/or ovarian cancer syndrome?",
    "seeds": [
      "Hereditary breast and/or ovarian cancer syndrome"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03376",
    "question": "What is associated with Intellectual disability-short stature-hypertelorism syndrome?",
    "seeds": [
      "Intellectual disability-short stature-hypertelorism syndrome"
    ],
    "gold_answer": "Abnormal zygomatic bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03377",
    "question": "What is associated with Corneal amyloidosis?",
    "seeds": [
      "Corneal amyloidosis"
    ],
    "gold_answer": "Amyloid deposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03378",
    "question": "What is associated with Abnormal intramembranous ossification?",
    "seeds": [
      "Abnormal intramembranous ossification"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03379",
    "question": "What is associated with Camptodactyly of 2nd-5th fingers?",
    "seeds": [
      "Camptodactyly of 2nd-5th fingers"
    ],
    "gold_answer": "Flexion contracture of digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03380",
    "question": "What is associated with Skin dimple over apex of long bone angulation?",
    "seeds": [
      "Skin dimple over apex of long bone angulation"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03381",
    "question": "What is associated with Intellectual developmental disorder, X-linked 93?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 93"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03382",
    "question": "What is associated with Choroid plexus cyst?",
    "seeds": [
      "Choroid plexus cyst"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03383",
    "question": "What is associated with Polyclonal elevation of IgM?",
    "seeds": [
      "Polyclonal elevation of IgM"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03384",
    "question": "What is associated with Fragile X-associated primary ovarian insufficiency?",
    "seeds": [
      "Fragile X-associated primary ovarian insufficiency"
    ],
    "gold_answer": "FMR1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03385",
    "question": "What is associated with Abnormal glomerular mesangial matrix morphology?",
    "seeds": [
      "Abnormal glomerular mesangial matrix morphology"
    ],
    "gold_answer": "Abnormal glomerular mesangium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03386",
    "question": "What is associated with Broad phalanx?",
    "seeds": [
      "Broad phalanx"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03387",
    "question": "What is associated with Neurocutaneous melanosis, somatic?",
    "seeds": [
      "Neurocutaneous melanosis, somatic"
    ],
    "gold_answer": "Abnormal affect regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03388",
    "question": "What phenotype is associated with FOXG1 syndrome?",
    "seeds": [
      "FOXG1 syndrome"
    ],
    "gold_answer": "Abnormal corpus callosum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03389",
    "question": "What is associated with Posterior vitreous detachment?",
    "seeds": [
      "Posterior vitreous detachment"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03390",
    "question": "What phenotype is associated with Gestational choriocarcinoma?",
    "seeds": [
      "Gestational choriocarcinoma"
    ],
    "gold_answer": "Spontaneous abortion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03391",
    "question": "What is associated with Microcornea?",
    "seeds": [
      "Microcornea"
    ],
    "gold_answer": "Abnormality of corneal size",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03392",
    "question": "What is associated with Neonatal electro-clinical seizure with behavior arrest?",
    "seeds": [
      "Neonatal electro-clinical seizure with behavior arrest"
    ],
    "gold_answer": "Neonatal seizure with electrographic correlate",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03393",
    "question": "What is associated with Congenital abnormal hair pattern?",
    "seeds": [
      "Congenital abnormal hair pattern"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03394",
    "question": "What phenotype is associated with Benign cephalic histiocytosis?",
    "seeds": [
      "Benign cephalic histiocytosis"
    ],
    "gold_answer": "Papule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03395",
    "question": "What is associated with Erythrocyte lactate transporter defect?",
    "seeds": [
      "Erythrocyte lactate transporter defect"
    ],
    "gold_answer": "Muscle spasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03396",
    "question": "What is associated with Self-limited neonatal epilepsy?",
    "seeds": [
      "Self-limited neonatal epilepsy"
    ],
    "gold_answer": "Abnormal facial expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03397",
    "question": "What is associated with Protein craving?",
    "seeds": [
      "Protein craving"
    ],
    "gold_answer": "Abnormal consumption behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03398",
    "question": "What is associated with Thiamine-responsive megaloblastic anemia?",
    "seeds": [
      "Thiamine-responsive megaloblastic anemia"
    ],
    "gold_answer": "Megaloblastic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03399",
    "question": "What is associated with X-linked intellectual disability-short stature-overweight syndrome?",
    "seeds": [
      "X-linked intellectual disability-short stature-overweight syndrome"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03400",
    "question": "What is associated with Acute?",
    "seeds": [
      "Acute"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03401",
    "question": "What is associated with Abnormality of ocular abduction?",
    "seeds": [
      "Abnormality of ocular abduction"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03402",
    "question": "What is associated with ACTH-independent macronodular adrenal hyperplasia 2?",
    "seeds": [
      "ACTH-independent macronodular adrenal hyperplasia 2"
    ],
    "gold_answer": "Abnormal circulating adrenocorticotropin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03403",
    "question": "What is associated with Severe combined immunodeficiency due to FOXN1 deficiency?",
    "seeds": [
      "Severe combined immunodeficiency due to FOXN1 deficiency"
    ],
    "gold_answer": "FOXN1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03404",
    "question": "What is associated with SPONDYLOLISTHESIS?",
    "seeds": [
      "SPONDYLOLISTHESIS"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03405",
    "question": "What is associated with Polycystic kidney disease 2?",
    "seeds": [
      "Polycystic kidney disease 2"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03406",
    "question": "What is associated with Deafness, mid-tone neural?",
    "seeds": [
      "Deafness, mid-tone neural"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03407",
    "question": "What is associated with Coenzyme Q10 deficiency, primary, 8?",
    "seeds": [
      "Coenzyme Q10 deficiency, primary, 8"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03408",
    "question": "What is associated with Increased mean corpuscular hemoglobin concentration?",
    "seeds": [
      "Increased mean corpuscular hemoglobin concentration"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03409",
    "question": "What is associated with Myeloschisis?",
    "seeds": [
      "Myeloschisis"
    ],
    "gold_answer": "Abnormal neural tube morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03410",
    "question": "What phenotype is associated with Macrocephaly-intellectual disability-left ventricular non compaction syndrome?",
    "seeds": [
      "Macrocephaly-intellectual disability-left ventricular non compaction syndrome"
    ],
    "gold_answer": "Poor head control",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03411",
    "question": "What phenotype is associated with Craniorachischisis?",
    "seeds": [
      "Craniorachischisis"
    ],
    "gold_answer": "Cervical spina bifida",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03412",
    "question": "What is associated with Deafness, autosomal recessive 77?",
    "seeds": [
      "Deafness, autosomal recessive 77"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03413",
    "question": "What is associated with Scalp edema?",
    "seeds": [
      "Scalp edema"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03414",
    "question": "What phenotype is associated with Neuropathy, hereditary motor, with myopathic features?",
    "seeds": [
      "Neuropathy, hereditary motor, with myopathic features"
    ],
    "gold_answer": "Motor axonal neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03415",
    "question": "What phenotype is associated with Cystic hamartoma of lung and kidney?",
    "seeds": [
      "Cystic hamartoma of lung and kidney"
    ],
    "gold_answer": "Multicystic kidney dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03416",
    "question": "What is associated with Respiratory failure requiring assisted ventilation?",
    "seeds": [
      "Respiratory failure requiring assisted ventilation"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03417",
    "question": "What is associated with Prominent interdigital folds?",
    "seeds": [
      "Prominent interdigital folds"
    ],
    "gold_answer": "Abnormal dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03418",
    "question": "What is associated with Chylous ascites?",
    "seeds": [
      "Chylous ascites"
    ],
    "gold_answer": "Abnormality of pancreas physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03419",
    "question": "What is associated with Anti-GABA(B)R antibody?",
    "seeds": [
      "Anti-GABA(B)R antibody"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03420",
    "question": "What is associated with Crossed polysyndactyly?",
    "seeds": [
      "Crossed polysyndactyly"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03421",
    "question": "What is associated with Alcohol sensitivity, acute?",
    "seeds": [
      "Alcohol sensitivity, acute"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03422",
    "question": "What is associated with Megaloblastic bone marrow?",
    "seeds": [
      "Megaloblastic bone marrow"
    ],
    "gold_answer": "Abnormal bone marrow cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03423",
    "question": "What phenotype is associated with Cryptotia, familial?",
    "seeds": [
      "Cryptotia, familial"
    ],
    "gold_answer": "Cryptotia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03424",
    "question": "What is associated with Complete diaphragmatic absence of pericardium?",
    "seeds": [
      "Complete diaphragmatic absence of pericardium"
    ],
    "gold_answer": "Congenital defect of the pericardium",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03425",
    "question": "What is associated with Neutrophilic urticarial dermatosis?",
    "seeds": [
      "Neutrophilic urticarial dermatosis"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03426",
    "question": "What is associated with Abnormal lacrimal gland morphology?",
    "seeds": [
      "Abnormal lacrimal gland morphology"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03427",
    "question": "What is associated with Complete duplication of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Complete duplication of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03428",
    "question": "What is associated with Quotidian fever?",
    "seeds": [
      "Quotidian fever"
    ],
    "gold_answer": "Recurrent fever",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03429",
    "question": "What is associated with Elevated vascular endothelial growth factor level?",
    "seeds": [
      "Elevated vascular endothelial growth factor level"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03430",
    "question": "What is associated with Allantoic cyst?",
    "seeds": [
      "Allantoic cyst"
    ],
    "gold_answer": "Abnormality of the urachus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03431",
    "question": "What is associated with Cutis laxa, autosomal dominant 2?",
    "seeds": [
      "Cutis laxa, autosomal dominant 2"
    ],
    "gold_answer": "Abnormal mitral valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03432",
    "question": "What is associated with Complete duplication of the distal phalanx of the 5th toe?",
    "seeds": [
      "Complete duplication of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Duplication of the phalanges of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03433",
    "question": "What is associated with Imagawa-Matsumoto syndrome?",
    "seeds": [
      "Imagawa-Matsumoto syndrome"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03434",
    "question": "What is associated with Alzheimer disease 3?",
    "seeds": [
      "Alzheimer disease 3"
    ],
    "gold_answer": "Abnormal spinal cord physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03435",
    "question": "What is associated with Cardiomyocyte hypertrophy?",
    "seeds": [
      "Cardiomyocyte hypertrophy"
    ],
    "gold_answer": "Abnormal cardiomyocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03436",
    "question": "What is associated with Curly eyelashes?",
    "seeds": [
      "Curly eyelashes"
    ],
    "gold_answer": "Abnormal eyelash morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03437",
    "question": "What phenotype is associated with Peters plus syndrome?",
    "seeds": [
      "Peters plus syndrome"
    ],
    "gold_answer": "Peters anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03438",
    "question": "What is associated with Prominent veins on trunk?",
    "seeds": [
      "Prominent veins on trunk"
    ],
    "gold_answer": "Prominent superficial blood vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03439",
    "question": "What is associated with SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2?",
    "seeds": [
      "SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03440",
    "question": "What is associated with Recurrent long bone fractures?",
    "seeds": [
      "Recurrent long bone fractures"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03441",
    "question": "What is associated with Cardiac rhabdomyoma?",
    "seeds": [
      "Cardiac rhabdomyoma"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03442",
    "question": "What is associated with Periapical bone loss?",
    "seeds": [
      "Periapical bone loss"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03443",
    "question": "What is associated with Craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome?",
    "seeds": [
      "Craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03444",
    "question": "What is associated with Periodic limb movements of sleep?",
    "seeds": [
      "Periodic limb movements of sleep"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03445",
    "question": "What is associated with Bilateral triphalangeal thumbs?",
    "seeds": [
      "Bilateral triphalangeal thumbs"
    ],
    "gold_answer": "Triphalangeal thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03446",
    "question": "What is associated with HbC hemoglobin?",
    "seeds": [
      "HbC hemoglobin"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03447",
    "question": "What is associated with Respiratory insufficiency?",
    "seeds": [
      "Respiratory insufficiency"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03448",
    "question": "What phenotype is associated with Hereditary pheochromocytoma-paraganglioma?",
    "seeds": [
      "Hereditary pheochromocytoma-paraganglioma"
    ],
    "gold_answer": "Adrenal pheochromocytoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03449",
    "question": "What is associated with Atrophic pituitary gland?",
    "seeds": [
      "Atrophic pituitary gland"
    ],
    "gold_answer": "Abnormal size of pituitary gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03450",
    "question": "What is associated with Amyotrophy involving the shoulder musculature?",
    "seeds": [
      "Amyotrophy involving the shoulder musculature"
    ],
    "gold_answer": "Abnormality of the musculature of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03451",
    "question": "What is associated with Delay in the acquisition of cooperative play skills?",
    "seeds": [
      "Delay in the acquisition of cooperative play skills"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03452",
    "question": "What is associated with Cogan syndrome?",
    "seeds": [
      "Cogan syndrome"
    ],
    "gold_answer": "Vasculitis by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03453",
    "question": "What is associated with Granulomatosis?",
    "seeds": [
      "Granulomatosis"
    ],
    "gold_answer": "Abnormal macrophage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03454",
    "question": "What phenotype is associated with Faciomandibular myoclonus, nocturnal?",
    "seeds": [
      "Faciomandibular myoclonus, nocturnal"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03455",
    "question": "What is associated with Anti-pituitary antibody positivity?",
    "seeds": [
      "Anti-pituitary antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03456",
    "question": "What is associated with Preaxial foot polydactyly?",
    "seeds": [
      "Preaxial foot polydactyly"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03457",
    "question": "What is associated with Hypocalcification of dental enamel?",
    "seeds": [
      "Hypocalcification of dental enamel"
    ],
    "gold_answer": "Enamel hypomineralization",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03458",
    "question": "What is associated with Stippled calcification in carpal bones?",
    "seeds": [
      "Stippled calcification in carpal bones"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03459",
    "question": "What is associated with Premature graying of body hair?",
    "seeds": [
      "Premature graying of body hair"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03460",
    "question": "What is associated with Megaloblastic erythroid hyperplasia?",
    "seeds": [
      "Megaloblastic erythroid hyperplasia"
    ],
    "gold_answer": "Erythroid hyperplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03461",
    "question": "What is associated with Ceroid lipofuscinosis, neuronal, 2?",
    "seeds": [
      "Ceroid lipofuscinosis, neuronal, 2"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03462",
    "question": "What is associated with Absent stapes?",
    "seeds": [
      "Absent stapes"
    ],
    "gold_answer": "Abnormality of the middle ear ossicles",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03463",
    "question": "What is associated with Palmoplantar keratoderma, nonepidermolytic, focal 1?",
    "seeds": [
      "Palmoplantar keratoderma, nonepidermolytic, focal 1"
    ],
    "gold_answer": "Hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03464",
    "question": "What is associated with Decreased circulating vitamin E concentration?",
    "seeds": [
      "Decreased circulating vitamin E concentration"
    ],
    "gold_answer": "Abnormal metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03465",
    "question": "What phenotype is associated with Factor X deficiency?",
    "seeds": [
      "Factor X deficiency"
    ],
    "gold_answer": "Epistaxis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03466",
    "question": "What is associated with Elevated CSF 4-hydroxybutyric acid concentration?",
    "seeds": [
      "Elevated CSF 4-hydroxybutyric acid concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03467",
    "question": "What is associated with Hemoglobin E disease?",
    "seeds": [
      "Hemoglobin E disease"
    ],
    "gold_answer": "Abnormal abdomen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03468",
    "question": "What is associated with Nephropathy, progressive tubulointerstitial, with cholestatic liverdisease?",
    "seeds": [
      "Nephropathy, progressive tubulointerstitial, with cholestatic liverdisease"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03469",
    "question": "What is associated with Rectal abscess?",
    "seeds": [
      "Rectal abscess"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03470",
    "question": "What is associated with Anti-varicella-zoster antibody positivity?",
    "seeds": [
      "Anti-varicella-zoster antibody positivity"
    ],
    "gold_answer": "Bloodstream virus-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03471",
    "question": "What is associated with Toe syndactyly?",
    "seeds": [
      "Toe syndactyly"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03472",
    "question": "What is associated with Rhabdoid tumor of the kidney?",
    "seeds": [
      "Rhabdoid tumor of the kidney"
    ],
    "gold_answer": "Renal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03473",
    "question": "What is associated with Flexion contracture of the 2nd finger?",
    "seeds": [
      "Flexion contracture of the 2nd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03474",
    "question": "What is associated with Abnormal skin adnexa morphology?",
    "seeds": [
      "Abnormal skin adnexa morphology"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03475",
    "question": "What is associated with Vulto-van Silfout-de Vries syndrome?",
    "seeds": [
      "Vulto-van Silfout-de Vries syndrome"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03476",
    "question": "What is associated with Abnormal CSF protein concentration?",
    "seeds": [
      "Abnormal CSF protein concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03477",
    "question": "What is associated with Basal ganglia calcification, idiopathic, 4?",
    "seeds": [
      "Basal ganglia calcification, idiopathic, 4"
    ],
    "gold_answer": "Disinhibition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03478",
    "question": "What phenotype is associated with X-linked intellectual disability-psychosis-macroorchidism syndrome?",
    "seeds": [
      "X-linked intellectual disability-psychosis-macroorchidism syndrome"
    ],
    "gold_answer": "Aggressive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03479",
    "question": "What is associated with Oval pupil?",
    "seeds": [
      "Oval pupil"
    ],
    "gold_answer": "Abnormal pupil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03480",
    "question": "What is associated with Arcuate vein medial hypertrophy?",
    "seeds": [
      "Arcuate vein medial hypertrophy"
    ],
    "gold_answer": "Abnormal intrarenal vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03481",
    "question": "What is associated with STT3A-CDG?",
    "seeds": [
      "STT3A-CDG"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03482",
    "question": "What phenotype is associated with Basilar impression, primary?",
    "seeds": [
      "Basilar impression, primary"
    ],
    "gold_answer": "Cervical myelopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03483",
    "question": "What is associated with Short stature, idiopathic familial?",
    "seeds": [
      "Short stature, idiopathic familial"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03484",
    "question": "What is associated with P mitrale?",
    "seeds": [
      "P mitrale"
    ],
    "gold_answer": "Abnormal P wave",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03485",
    "question": "What is associated with Ocular pruritus?",
    "seeds": [
      "Ocular pruritus"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03486",
    "question": "What phenotype is associated with Epidermolytic hyperkeratosis 2?",
    "seeds": [
      "Epidermolytic hyperkeratosis 2"
    ],
    "gold_answer": "Palmoplantar keratoderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03487",
    "question": "What phenotype is associated with Combined oxidative phosphorylation deficiency 56?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 56"
    ],
    "gold_answer": "Failure to thrive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03488",
    "question": "What is associated with Aplasia/Hypoplasia of the ovary?",
    "seeds": [
      "Aplasia/Hypoplasia of the ovary"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03489",
    "question": "What is associated with Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia?",
    "seeds": [
      "Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03490",
    "question": "What is associated with Small distal femoral epiphysis?",
    "seeds": [
      "Small distal femoral epiphysis"
    ],
    "gold_answer": "Abnormality of the distal femoral epiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03491",
    "question": "What is associated with Elevated urine hyaluronic acid level?",
    "seeds": [
      "Elevated urine hyaluronic acid level"
    ],
    "gold_answer": "Urinary glycosaminoglycan excretion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03492",
    "question": "What is associated with Multiple biliary hamartomas?",
    "seeds": [
      "Multiple biliary hamartomas"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03493",
    "question": "What is associated with Elevated circulating acetylcarnitine concentration?",
    "seeds": [
      "Elevated circulating acetylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating short-chain acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03494",
    "question": "What is associated with Decreased male libido?",
    "seeds": [
      "Decreased male libido"
    ],
    "gold_answer": "Decreased libido",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03495",
    "question": "What is associated with Periosteal new bone of humerus?",
    "seeds": [
      "Periosteal new bone of humerus"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03496",
    "question": "What is associated with Spleen hamartoma?",
    "seeds": [
      "Spleen hamartoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03497",
    "question": "What is associated with Abnormal earlobe morphology?",
    "seeds": [
      "Abnormal earlobe morphology"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03498",
    "question": "What is associated with Focal impaired awareness undressing automatism seizure?",
    "seeds": [
      "Focal impaired awareness undressing automatism seizure"
    ],
    "gold_answer": "Focal undressing automatism seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03499",
    "question": "What is associated with PGM3-CDG?",
    "seeds": [
      "PGM3-CDG"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03500",
    "question": "What is associated with Elevated circulating PINP concentration?",
    "seeds": [
      "Elevated circulating PINP concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03501",
    "question": "What is associated with Spinocerebellar ataxia type 34?",
    "seeds": [
      "Spinocerebellar ataxia type 34"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03502",
    "question": "What is associated with Fractured thoracic vertebra?",
    "seeds": [
      "Fractured thoracic vertebra"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03503",
    "question": "What is associated with Tremor, hereditary essential, 5?",
    "seeds": [
      "Tremor, hereditary essential, 5"
    ],
    "gold_answer": "Tremor by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03504",
    "question": "What phenotype is associated with Hyperlysinemia?",
    "seeds": [
      "Hyperlysinemia"
    ],
    "gold_answer": "Hematuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03505",
    "question": "What is associated with Elevated circulating succinate?",
    "seeds": [
      "Elevated circulating succinate"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03506",
    "question": "What is associated with Oculocerebrofacial syndrome, Kaufman type?",
    "seeds": [
      "Oculocerebrofacial syndrome, Kaufman type"
    ],
    "gold_answer": "Abnormality of mouth size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03507",
    "question": "What is associated with Palmoplantar cutis laxa?",
    "seeds": [
      "Palmoplantar cutis laxa"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03508",
    "question": "What is associated with Agammaglobulinemia 3, autosomal recessive?",
    "seeds": [
      "Agammaglobulinemia 3, autosomal recessive"
    ],
    "gold_answer": "Abnormal bronchus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03509",
    "question": "What is associated with Hyperprolinemia type 1?",
    "seeds": [
      "Hyperprolinemia type 1"
    ],
    "gold_answer": "PRODH",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03510",
    "question": "What is associated with Equinovarus deformity?",
    "seeds": [
      "Equinovarus deformity"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03511",
    "question": "What is associated with Calcium channel blocker exposure?",
    "seeds": [
      "Calcium channel blocker exposure"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03512",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 55?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 55"
    ],
    "gold_answer": "Talipes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03513",
    "question": "What is associated with Renal tubulopathy-encephalopathy-liver failure syndrome?",
    "seeds": [
      "Renal tubulopathy-encephalopathy-liver failure syndrome"
    ],
    "gold_answer": "BCS1L",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03514",
    "question": "What is associated with Anesthesic-triggered malignant hyperthermia?",
    "seeds": [
      "Anesthesic-triggered malignant hyperthermia"
    ],
    "gold_answer": "Malignant hyperthermia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03515",
    "question": "What is associated with Decreased pituitary glycoprotein hormone alpha subunit level?",
    "seeds": [
      "Decreased pituitary glycoprotein hormone alpha subunit level"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03516",
    "question": "What is associated with Isolated autosomal dominant hypomagnesemia, Glaudemans type?",
    "seeds": [
      "Isolated autosomal dominant hypomagnesemia, Glaudemans type"
    ],
    "gold_answer": "KCNA1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03517",
    "question": "What is associated with Pollakisuria?",
    "seeds": [
      "Pollakisuria"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03518",
    "question": "What is associated with Parkinson disease 24, autosomal dominant, susceptibility to?",
    "seeds": [
      "Parkinson disease 24, autosomal dominant, susceptibility to"
    ],
    "gold_answer": "Abnormal emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03519",
    "question": "What is associated with Non-caseating epithelioid cell granulomatosis?",
    "seeds": [
      "Non-caseating epithelioid cell granulomatosis"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03520",
    "question": "What is associated with Growth without growth hormone?",
    "seeds": [
      "Growth without growth hormone"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03521",
    "question": "What is associated with Reduced muscle fiber alpha dystroglycan?",
    "seeds": [
      "Reduced muscle fiber alpha dystroglycan"
    ],
    "gold_answer": "Abnormal muscle fiber alpha dystroglycan",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03522",
    "question": "What is associated with Sterile pyuria?",
    "seeds": [
      "Sterile pyuria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03523",
    "question": "What is associated with Short third metatarsal?",
    "seeds": [
      "Short third metatarsal"
    ],
    "gold_answer": "Abnormal metatarsal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03524",
    "question": "What is associated with Posterior capsular cataract?",
    "seeds": [
      "Posterior capsular cataract"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03525",
    "question": "What is associated with Focal segmental glomerulosclerosis 9?",
    "seeds": [
      "Focal segmental glomerulosclerosis 9"
    ],
    "gold_answer": "Nephrotic syndrome",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03526",
    "question": "What is associated with Amelogenesis imperfecta, type IIIB?",
    "seeds": [
      "Amelogenesis imperfecta, type IIIB"
    ],
    "gold_answer": "Tooth malposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03527",
    "question": "What is associated with Autoinflammatory syndrome, familial, X-linked, Behcet-like 2?",
    "seeds": [
      "Autoinflammatory syndrome, familial, X-linked, Behcet-like 2"
    ],
    "gold_answer": "Anal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03528",
    "question": "What is associated with FLNC-related handgrip and calf weakness-distal myopathy?",
    "seeds": [
      "FLNC-related handgrip and calf weakness-distal myopathy"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03529",
    "question": "What phenotype is associated with MOMO syndrome?",
    "seeds": [
      "MOMO syndrome"
    ],
    "gold_answer": "Hyperconvex nail",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03530",
    "question": "What is associated with Air crescent?",
    "seeds": [
      "Air crescent"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03531",
    "question": "What phenotype is associated with Microcephaly-micromelia syndrome?",
    "seeds": [
      "Microcephaly-micromelia syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03532",
    "question": "What is associated with Congenital hip dislocation?",
    "seeds": [
      "Congenital hip dislocation"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03533",
    "question": "What is associated with Calcified placenta?",
    "seeds": [
      "Calcified placenta"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03534",
    "question": "What is associated with Carcinoid syndrome?",
    "seeds": [
      "Carcinoid syndrome"
    ],
    "gold_answer": "Skin plaque",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03535",
    "question": "What is associated with Bleeding disorder due to P2Y12 defect?",
    "seeds": [
      "Bleeding disorder due to P2Y12 defect"
    ],
    "gold_answer": "P2RY12",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03536",
    "question": "What is associated with Thin skin?",
    "seeds": [
      "Thin skin"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03537",
    "question": "What is associated with Gastric carcinoid tumor?",
    "seeds": [
      "Gastric carcinoid tumor"
    ],
    "gold_answer": "Neuroendocrine neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03538",
    "question": "What is associated with Vaguely nodular lymph-node architecture?",
    "seeds": [
      "Vaguely nodular lymph-node architecture"
    ],
    "gold_answer": "Altered lymph-node tissue architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03539",
    "question": "What phenotype is associated with Albinism-deafness syndrome?",
    "seeds": [
      "Albinism-deafness syndrome"
    ],
    "gold_answer": "Aganglionic megacolon",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03540",
    "question": "What is associated with Acquired aphakia?",
    "seeds": [
      "Acquired aphakia"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03541",
    "question": "What is associated with Epilepsy, nocturnal frontal lobe, type 1?",
    "seeds": [
      "Epilepsy, nocturnal frontal lobe, type 1"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03542",
    "question": "What is associated with Optic atrophy from cranial nerve compression?",
    "seeds": [
      "Optic atrophy from cranial nerve compression"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03543",
    "question": "What is associated with Decreased circulating ADAMTS13 activity?",
    "seeds": [
      "Decreased circulating ADAMTS13 activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03544",
    "question": "What is associated with Abnormal dental root morphology?",
    "seeds": [
      "Abnormal dental root morphology"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03545",
    "question": "What is associated with Epidermolysis bullosa simplex 1B, generalized intermediate?",
    "seeds": [
      "Epidermolysis bullosa simplex 1B, generalized intermediate"
    ],
    "gold_answer": "Blistering by anatomical location",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03546",
    "question": "What is associated with Hermansky-Pudlak syndrome 2?",
    "seeds": [
      "Hermansky-Pudlak syndrome 2"
    ],
    "gold_answer": "Abnormal upper lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03547",
    "question": "What is associated with Lingual dystonia?",
    "seeds": [
      "Lingual dystonia"
    ],
    "gold_answer": "Craniofacial dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03548",
    "question": "What is associated with Difficulty recognizing another's emotions?",
    "seeds": [
      "Difficulty recognizing another's emotions"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03549",
    "question": "What is associated with Pancreatic cancer, susceptibility to, 2?",
    "seeds": [
      "Pancreatic cancer, susceptibility to, 2"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03550",
    "question": "What is associated with Venous varicosities of celiac and mesenteric vessels?",
    "seeds": [
      "Venous varicosities of celiac and mesenteric vessels"
    ],
    "gold_answer": "Venous insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03551",
    "question": "What is associated with Anti-GlyR antibody?",
    "seeds": [
      "Anti-GlyR antibody"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03552",
    "question": "What is associated with Vascular malformation of the lip?",
    "seeds": [
      "Vascular malformation of the lip"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03553",
    "question": "What phenotype is associated with Anaplastic thyroid carcinoma?",
    "seeds": [
      "Anaplastic thyroid carcinoma"
    ],
    "gold_answer": "Neoplasm of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03554",
    "question": "What is associated with Retinal vasculitis?",
    "seeds": [
      "Retinal vasculitis"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03555",
    "question": "What is associated with Anaplastic large-cell lymphoma?",
    "seeds": [
      "Anaplastic large-cell lymphoma"
    ],
    "gold_answer": "Non-Hodgkin lymphoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03556",
    "question": "What is associated with Abnormal fetal nasal bone visualization?",
    "seeds": [
      "Abnormal fetal nasal bone visualization"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03557",
    "question": "What is associated with Osteolytic defects of the phalanges of the toes?",
    "seeds": [
      "Osteolytic defects of the phalanges of the toes"
    ],
    "gold_answer": "Osteolysis involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03558",
    "question": "What is associated with Calcification of the small brain vessels?",
    "seeds": [
      "Calcification of the small brain vessels"
    ],
    "gold_answer": "Abnormal cerebral artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03559",
    "question": "What is associated with Cutaneous anergy?",
    "seeds": [
      "Cutaneous anergy"
    ],
    "gold_answer": "Abnormal T cell physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03560",
    "question": "What is associated with Sarcoidosis, susceptibility to, 2?",
    "seeds": [
      "Sarcoidosis, susceptibility to, 2"
    ],
    "gold_answer": "Abnormality of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03561",
    "question": "What is associated with Elevated urine 2-trans,4-cis-decadienoylcarnitine level?",
    "seeds": [
      "Elevated urine 2-trans,4-cis-decadienoylcarnitine level"
    ],
    "gold_answer": "Abnormal concentration of acylcarnitine in the urine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03562",
    "question": "What is associated with Capillary malformation of the lip?",
    "seeds": [
      "Capillary malformation of the lip"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03563",
    "question": "What is associated with Usher syndrome, type IIA?",
    "seeds": [
      "Usher syndrome, type IIA"
    ],
    "gold_answer": "Retinal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03564",
    "question": "What is associated with Basal ganglia calcification, idiopathic, 11, autosomal recessive?",
    "seeds": [
      "Basal ganglia calcification, idiopathic, 11, autosomal recessive"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03565",
    "question": "What phenotype is associated with Brachydactyly, type A6?",
    "seeds": [
      "Brachydactyly, type A6"
    ],
    "gold_answer": "Type A brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03566",
    "question": "What is associated with Entropion?",
    "seeds": [
      "Entropion"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03567",
    "question": "What is associated with Muscle weakness?",
    "seeds": [
      "Muscle weakness"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03568",
    "question": "What is associated with Cortical radial artery intima/media liquefactive necrosis?",
    "seeds": [
      "Cortical radial artery intima/media liquefactive necrosis"
    ],
    "gold_answer": "Abnormal cortical radial artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03569",
    "question": "What is associated with Cystathioninemia?",
    "seeds": [
      "Cystathioninemia"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03570",
    "question": "What is associated with Immunodeficiency 47?",
    "seeds": [
      "Immunodeficiency 47"
    ],
    "gold_answer": "Functional motor deficit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03571",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 37?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 37"
    ],
    "gold_answer": "Disinhibition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03572",
    "question": "What is associated with Limited shoulder external rotation?",
    "seeds": [
      "Limited shoulder external rotation"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03573",
    "question": "What is associated with Bronchocele?",
    "seeds": [
      "Bronchocele"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03574",
    "question": "What phenotype is associated with Renal failure, progressive, with hypertension?",
    "seeds": [
      "Renal failure, progressive, with hypertension"
    ],
    "gold_answer": "Stage 5 chronic kidney disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03575",
    "question": "What is associated with Deafness, autosomal dominant 82?",
    "seeds": [
      "Deafness, autosomal dominant 82"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03576",
    "question": "What is associated with Lissencephaly type 1 due to doublecortin gene mutation?",
    "seeds": [
      "Lissencephaly type 1 due to doublecortin gene mutation"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03577",
    "question": "What is associated with No social interaction?",
    "seeds": [
      "No social interaction"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03578",
    "question": "What is associated with Short 4th toe?",
    "seeds": [
      "Short 4th toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03579",
    "question": "What is associated with Increased level of 3-hydroxy-3-methylglutaric acid in urine?",
    "seeds": [
      "Increased level of 3-hydroxy-3-methylglutaric acid in urine"
    ],
    "gold_answer": "Dicarboxylic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03580",
    "question": "What phenotype is associated with Corneal dystrophy, Central type?",
    "seeds": [
      "Corneal dystrophy, Central type"
    ],
    "gold_answer": "Central corneal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03581",
    "question": "What is associated with Ciliary dyskinesia, primary, 46?",
    "seeds": [
      "Ciliary dyskinesia, primary, 46"
    ],
    "gold_answer": "Sinusitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03582",
    "question": "What phenotype is associated with Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis?",
    "seeds": [
      "Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis"
    ],
    "gold_answer": "Inappropriate crying",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03583",
    "question": "What is associated with Elevated circulating saccharopine concentration?",
    "seeds": [
      "Elevated circulating saccharopine concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03584",
    "question": "What is associated with Reduced erythrocyte glutathione reductase activity?",
    "seeds": [
      "Reduced erythrocyte glutathione reductase activity"
    ],
    "gold_answer": "Abnormal erythrocyte enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03585",
    "question": "What is associated with Abnormal phagocytosis?",
    "seeds": [
      "Abnormal phagocytosis"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03586",
    "question": "What is associated with Reduced granulocyte surface marker level?",
    "seeds": [
      "Reduced granulocyte surface marker level"
    ],
    "gold_answer": "Reduced cell surface marker level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03587",
    "question": "What is associated with Abnormal 2nd finger morphology?",
    "seeds": [
      "Abnormal 2nd finger morphology"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03588",
    "question": "What is associated with Upbeat nystagmus?",
    "seeds": [
      "Upbeat nystagmus"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03589",
    "question": "What is associated with Bile acid synthesis defect, congenital, 3?",
    "seeds": [
      "Bile acid synthesis defect, congenital, 3"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03590",
    "question": "What is associated with Abnormality of skeletal muscle fiber size?",
    "seeds": [
      "Abnormality of skeletal muscle fiber size"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03591",
    "question": "What is associated with Pontocerebellar hypoplasia, type 2F?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 2F"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03592",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type Iw?",
    "seeds": [
      "Congenital disorder of glycosylation, type Iw"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03593",
    "question": "What is associated with Pelvis fracture?",
    "seeds": [
      "Pelvis fracture"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03594",
    "question": "What phenotype is associated with Spastic paraplegia 42, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 42, autosomal dominant"
    ],
    "gold_answer": "Babinski sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03595",
    "question": "What is associated with Sagliker syndrome?",
    "seeds": [
      "Sagliker syndrome"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03596",
    "question": "What is associated with Variegate porphyria, childhood-onset?",
    "seeds": [
      "Variegate porphyria, childhood-onset"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03597",
    "question": "What phenotype is associated with Brugada syndrome 7?",
    "seeds": [
      "Brugada syndrome 7"
    ],
    "gold_answer": "Permanent atrial fibrillation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03598",
    "question": "What is associated with Stippling of the epiphyses of the 2nd finger?",
    "seeds": [
      "Stippling of the epiphyses of the 2nd finger"
    ],
    "gold_answer": "Abnormal epiphyseal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03599",
    "question": "What is associated with Immunodeficiency 38 with basal ganglia calcification?",
    "seeds": [
      "Immunodeficiency 38 with basal ganglia calcification"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03600",
    "question": "What is associated with Ichthyosis, spastic quadriplegia, and impaired intellectual development?",
    "seeds": [
      "Ichthyosis, spastic quadriplegia, and impaired intellectual development"
    ],
    "gold_answer": "Appendicular spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03601",
    "question": "What is associated with Febrile seizures, familial, 6?",
    "seeds": [
      "Febrile seizures, familial, 6"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03602",
    "question": "What is associated with Digital clubbing, isolated congenital?",
    "seeds": [
      "Digital clubbing, isolated congenital"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03603",
    "question": "What is associated with Developmental and epileptic encephalopathy 119?",
    "seeds": [
      "Developmental and epileptic encephalopathy 119"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03604",
    "question": "What is associated with IRVAN syndrome?",
    "seeds": [
      "IRVAN syndrome"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03605",
    "question": "What is associated with Sabinas brittle hair syndrome?",
    "seeds": [
      "Sabinas brittle hair syndrome"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03606",
    "question": "What is associated with Delayed ossification of the trapezoid bone?",
    "seeds": [
      "Delayed ossification of the trapezoid bone"
    ],
    "gold_answer": "Abnormal carpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03607",
    "question": "What is associated with Hypercholesterolemia, familial, 2?",
    "seeds": [
      "Hypercholesterolemia, familial, 2"
    ],
    "gold_answer": "Nodular changes affecting the eyelids",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03608",
    "question": "What is associated with Reduced granulocyte CD55 level?",
    "seeds": [
      "Reduced granulocyte CD55 level"
    ],
    "gold_answer": "Reduced granulocyte surface marker level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03609",
    "question": "What phenotype is associated with Spermatogenic failure 50?",
    "seeds": [
      "Spermatogenic failure 50"
    ],
    "gold_answer": "Decreased testicular size",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03610",
    "question": "What phenotype is associated with Chorea, benign hereditary?",
    "seeds": [
      "Chorea, benign hereditary"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03611",
    "question": "What is associated with Type 1 muscle fiber atrophy?",
    "seeds": [
      "Type 1 muscle fiber atrophy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03612",
    "question": "What phenotype is associated with Arnold-Chiari malformation type I?",
    "seeds": [
      "Arnold-Chiari malformation type I"
    ],
    "gold_answer": "Cranial nerve paralysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03613",
    "question": "What is associated with Progressive spinal muscular atrophy?",
    "seeds": [
      "Progressive spinal muscular atrophy"
    ],
    "gold_answer": "Spinal muscular atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03614",
    "question": "What is associated with Progressive sensorineural hearing impairment?",
    "seeds": [
      "Progressive sensorineural hearing impairment"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03615",
    "question": "What is associated with Leukemia, acute myeloid?",
    "seeds": [
      "Leukemia, acute myeloid"
    ],
    "gold_answer": "Leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03616",
    "question": "What is associated with EGF-related primary hypomagnesemia with intellectual disability?",
    "seeds": [
      "EGF-related primary hypomagnesemia with intellectual disability"
    ],
    "gold_answer": "EGF",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03617",
    "question": "What is associated with Decreased fecal pH?",
    "seeds": [
      "Decreased fecal pH"
    ],
    "gold_answer": "Abnormal stool composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03618",
    "question": "What phenotype is associated with Congenital heart defects, multiple types, 8, with or without heterotaxy?",
    "seeds": [
      "Congenital heart defects, multiple types, 8, with or without heterotaxy"
    ],
    "gold_answer": "Short nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03619",
    "question": "What is associated with Hip subluxation?",
    "seeds": [
      "Hip subluxation"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03620",
    "question": "What is associated with Reduced factor XII activity?",
    "seeds": [
      "Reduced factor XII activity"
    ],
    "gold_answer": "Abnormality of the intrinsic pathway",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03621",
    "question": "What is associated with Prominent fingertip pads?",
    "seeds": [
      "Prominent fingertip pads"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03622",
    "question": "What is associated with Talonavicular coalition?",
    "seeds": [
      "Talonavicular coalition"
    ],
    "gold_answer": "Abnormal 5th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03623",
    "question": "What phenotype is associated with Madras motor neuron disease?",
    "seeds": [
      "Madras motor neuron disease"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03624",
    "question": "What is associated with Osteolytic defects of the phalanges of the 3rd toe?",
    "seeds": [
      "Osteolytic defects of the phalanges of the 3rd toe"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03625",
    "question": "What is associated with Porphyrinuria?",
    "seeds": [
      "Porphyrinuria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03626",
    "question": "What is associated with Colonic fibrinopurulent exudate?",
    "seeds": [
      "Colonic fibrinopurulent exudate"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03627",
    "question": "What is associated with Piebald trait?",
    "seeds": [
      "Piebald trait"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03628",
    "question": "What is associated with Stiff interphalangeal joints?",
    "seeds": [
      "Stiff interphalangeal joints"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03629",
    "question": "What is associated with Achilles tendon tear?",
    "seeds": [
      "Achilles tendon tear"
    ],
    "gold_answer": "Abnormal Achilles tendon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03630",
    "question": "What phenotype is associated with Chondrodysplasia punctata, autosomal dominantchondrodysplasia punctata due to vitamin K deficiency, included?",
    "seeds": [
      "Chondrodysplasia punctata, autosomal dominantchondrodysplasia punctata due to vitamin K deficiency, included"
    ],
    "gold_answer": "Epiphyseal stippling",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03631",
    "question": "What is associated with Anti-contactin-associated protein 1 antibody positivity?",
    "seeds": [
      "Anti-contactin-associated protein 1 antibody positivity"
    ],
    "gold_answer": "Anti-contactin-1 antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03632",
    "question": "What is associated with Elevated urinary quinolinic acid level?",
    "seeds": [
      "Elevated urinary quinolinic acid level"
    ],
    "gold_answer": "Abnormal urinary pyrimidine level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03633",
    "question": "What is associated with Abnormal tissue alpha-N-acetylglucosaminidase activity?",
    "seeds": [
      "Abnormal tissue alpha-N-acetylglucosaminidase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03634",
    "question": "What is associated with Glycogen storage disease due to aldolase A deficiency?",
    "seeds": [
      "Glycogen storage disease due to aldolase A deficiency"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03635",
    "question": "What is associated with Dentin dysplasia, type I, with microdontia and misshapen teeth?",
    "seeds": [
      "Dentin dysplasia, type I, with microdontia and misshapen teeth"
    ],
    "gold_answer": "Craniofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03636",
    "question": "What is associated with Abcd syndrome?",
    "seeds": [
      "Abcd syndrome"
    ],
    "gold_answer": "Abnormality of hair pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03637",
    "question": "What is associated with Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03638",
    "question": "What is associated with Ravine syndrome?",
    "seeds": [
      "Ravine syndrome"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03639",
    "question": "What is associated with Charcot-Marie-Tooth disease type 4B3?",
    "seeds": [
      "Charcot-Marie-Tooth disease type 4B3"
    ],
    "gold_answer": "SBF1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03640",
    "question": "What is associated with Decreased circulating ceruloplasmin concentration?",
    "seeds": [
      "Decreased circulating ceruloplasmin concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03641",
    "question": "What is associated with Posterior polymorphous corneal dystrophy?",
    "seeds": [
      "Posterior polymorphous corneal dystrophy"
    ],
    "gold_answer": "Sensory hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03642",
    "question": "What is associated with Personality disorder?",
    "seeds": [
      "Personality disorder"
    ],
    "gold_answer": "Impairment in personality functioning",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03643",
    "question": "What is associated with Elbow hypertrichosis?",
    "seeds": [
      "Elbow hypertrichosis"
    ],
    "gold_answer": "Hypertrichosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03644",
    "question": "What is associated with Bilateral elbow dislocations?",
    "seeds": [
      "Bilateral elbow dislocations"
    ],
    "gold_answer": "Abnormal elbow physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03645",
    "question": "What is associated with Laryngospasm?",
    "seeds": [
      "Laryngospasm"
    ],
    "gold_answer": "Abnormal larynx physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03646",
    "question": "What is associated with Broad proximal phalanx of the 4th toe?",
    "seeds": [
      "Broad proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal fourth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03647",
    "question": "What is associated with Ptosis-vocal cord paralysis syndrome?",
    "seeds": [
      "Ptosis-vocal cord paralysis syndrome"
    ],
    "gold_answer": "Proportionate short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03648",
    "question": "What is associated with Congenital malformation of the left heart?",
    "seeds": [
      "Congenital malformation of the left heart"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03649",
    "question": "What is associated with Short phalanx of the 3rd toe?",
    "seeds": [
      "Short phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the phalanges of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03650",
    "question": "What is associated with Neonatal hypoglycemia?",
    "seeds": [
      "Neonatal hypoglycemia"
    ],
    "gold_answer": "Abnormal blood glucose concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03651",
    "question": "What is associated with Asymmetric abdominal aortic aneurysm?",
    "seeds": [
      "Asymmetric abdominal aortic aneurysm"
    ],
    "gold_answer": "Aortic aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03652",
    "question": "What is associated with Pili torti-onychodysplasia syndrome?",
    "seeds": [
      "Pili torti-onychodysplasia syndrome"
    ],
    "gold_answer": "Abnormality of hair texture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03653",
    "question": "What phenotype is associated with Intellectual developmental disorder 61?",
    "seeds": [
      "Intellectual developmental disorder 61"
    ],
    "gold_answer": "Attention deficit hyperactivity disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03654",
    "question": "What is associated with Intracranial hemorrhage?",
    "seeds": [
      "Intracranial hemorrhage"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03655",
    "question": "What is associated with Vacuolar myopathy with sarcoplasmic reticulum protein aggregates?",
    "seeds": [
      "Vacuolar myopathy with sarcoplasmic reticulum protein aggregates"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03656",
    "question": "What is associated with Pulsatile mass in extremity?",
    "seeds": [
      "Pulsatile mass in extremity"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03657",
    "question": "What is associated with Citrullinemia type II?",
    "seeds": [
      "Citrullinemia type II"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03658",
    "question": "What is associated with Anti-annexin A5 antibody positivity?",
    "seeds": [
      "Anti-annexin A5 antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03659",
    "question": "What is associated with Increased CSF citrulline concentration?",
    "seeds": [
      "Increased CSF citrulline concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03660",
    "question": "What is associated with Pseudoepiphyses of the 4th finger?",
    "seeds": [
      "Pseudoepiphyses of the 4th finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03661",
    "question": "What is associated with Spastic paraplegia-severe developmental delay-epilepsy syndrome?",
    "seeds": [
      "Spastic paraplegia-severe developmental delay-epilepsy syndrome"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03662",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type Iip?",
    "seeds": [
      "Congenital disorder of glycosylation, type Iip"
    ],
    "gold_answer": "Hepatomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03663",
    "question": "What is associated with Anemia, nonspherocytic hemolytic, associated with abnormality of redcell membrane?",
    "seeds": [
      "Anemia, nonspherocytic hemolytic, associated with abnormality of redcell membrane"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03664",
    "question": "What is associated with Hallux symphalangism?",
    "seeds": [
      "Hallux symphalangism"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03665",
    "question": "What is associated with Storage pool platelet disease?",
    "seeds": [
      "Storage pool platelet disease"
    ],
    "gold_answer": "Hematological neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03666",
    "question": "What is associated with Temporomandibular arthritis?",
    "seeds": [
      "Temporomandibular arthritis"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03667",
    "question": "What is associated with Pityriasis rubra pilaris?",
    "seeds": [
      "Pityriasis rubra pilaris"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03668",
    "question": "What phenotype is associated with Mitochondrial complex III deficiency, nuclear type 7?",
    "seeds": [
      "Mitochondrial complex III deficiency, nuclear type 7"
    ],
    "gold_answer": "Hyperuricosuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03669",
    "question": "What is associated with Broad palm?",
    "seeds": [
      "Broad palm"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03670",
    "question": "What is associated with Schwartz-Jampel syndrome?",
    "seeds": [
      "Schwartz-Jampel syndrome"
    ],
    "gold_answer": "Focal dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03671",
    "question": "What phenotype is associated with Oguchi disease 1?",
    "seeds": [
      "Oguchi disease 1"
    ],
    "gold_answer": "Early-onset non-progressive night blindness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03672",
    "question": "What is associated with Copper deficiency, familial benign?",
    "seeds": [
      "Copper deficiency, familial benign"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03673",
    "question": "What is associated with Spinal muscular atrophy, type III?",
    "seeds": [
      "Spinal muscular atrophy, type III"
    ],
    "gold_answer": "Fasciculations",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03674",
    "question": "What is associated with Abnormality of the middle phalanx of the 4th finger?",
    "seeds": [
      "Abnormality of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03675",
    "question": "What is associated with CHARGE syndrome?",
    "seeds": [
      "CHARGE syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of facial bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03676",
    "question": "What is associated with Cataract 3, multiple types?",
    "seeds": [
      "Cataract 3, multiple types"
    ],
    "gold_answer": "GJA8",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_03677",
    "question": "What phenotype is associated with Focal segmental glomerulosclerosis 9?",
    "seeds": [
      "Focal segmental glomerulosclerosis 9"
    ],
    "gold_answer": "Focal segmental glomerulosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03678",
    "question": "What is associated with Abnormal number of erythroid precursors?",
    "seeds": [
      "Abnormal number of erythroid precursors"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03679",
    "question": "What phenotype is associated with Pallister-Hall-like syndrome?",
    "seeds": [
      "Pallister-Hall-like syndrome"
    ],
    "gold_answer": "Hypothalamic hamartoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03680",
    "question": "What is associated with Urinary bladder hamartoma?",
    "seeds": [
      "Urinary bladder hamartoma"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03681",
    "question": "What is associated with Elevated circulating myoglobin concentration?",
    "seeds": [
      "Elevated circulating myoglobin concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03682",
    "question": "What is associated with Neurodevelopmental disorder with early-onset seizures, facial dysmorphism, and behavioral abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with early-onset seizures, facial dysmorphism, and behavioral abnormalities"
    ],
    "gold_answer": "Status epilepticus without prominent motor symptoms",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03683",
    "question": "What is associated with Femoroacetabular impingement?",
    "seeds": [
      "Femoroacetabular impingement"
    ],
    "gold_answer": "Abnormal hip bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03684",
    "question": "What is associated with Split-Hand/foot malformation 1?",
    "seeds": [
      "Split-Hand/foot malformation 1"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03685",
    "question": "What is associated with Episodic flaccid weakness?",
    "seeds": [
      "Episodic flaccid weakness"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03686",
    "question": "What is associated with Fetal intra-abdominal umbilical vein varix?",
    "seeds": [
      "Fetal intra-abdominal umbilical vein varix"
    ],
    "gold_answer": "Umbilical vein varix",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03687",
    "question": "What is associated with X-linked complicated spastic paraplegia type 1?",
    "seeds": [
      "X-linked complicated spastic paraplegia type 1"
    ],
    "gold_answer": "Paraplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03688",
    "question": "What is associated with Reduction of neutrophil motility?",
    "seeds": [
      "Reduction of neutrophil motility"
    ],
    "gold_answer": "Abnormal neutrophil physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03689",
    "question": "What phenotype is associated with Pyruvate kinase deficiency of red cells?",
    "seeds": [
      "Pyruvate kinase deficiency of red cells"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03690",
    "question": "What is associated with Dysgammaglobulinemia?",
    "seeds": [
      "Dysgammaglobulinemia"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03691",
    "question": "What is associated with Paradoxical splitting of the second heart sound?",
    "seeds": [
      "Paradoxical splitting of the second heart sound"
    ],
    "gold_answer": "Abnormal second heart sound",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03692",
    "question": "What is associated with Mild phosphoribosylpyrophosphate synthetase superactivity?",
    "seeds": [
      "Mild phosphoribosylpyrophosphate synthetase superactivity"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03693",
    "question": "What is associated with Immunodeficiency-Centromeric instability-facial anomalies syndrome 3?",
    "seeds": [
      "Immunodeficiency-Centromeric instability-facial anomalies syndrome 3"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03694",
    "question": "What is associated with Autoimmune polyendocrinopathy type 2?",
    "seeds": [
      "Autoimmune polyendocrinopathy type 2"
    ],
    "gold_answer": "Abnormal thyroid-stimulating hormone level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03695",
    "question": "What is associated with Enlarged humeral head?",
    "seeds": [
      "Enlarged humeral head"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03696",
    "question": "What is associated with Short finger?",
    "seeds": [
      "Short finger"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03697",
    "question": "What is associated with Elbow fracture?",
    "seeds": [
      "Elbow fracture"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03698",
    "question": "What is associated with Elevated mitochondrial citrate synthase activity?",
    "seeds": [
      "Elevated mitochondrial citrate synthase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03699",
    "question": "What is associated with Two-raphe bicuspid aortic valve?",
    "seeds": [
      "Two-raphe bicuspid aortic valve"
    ],
    "gold_answer": "Abnormal aortic valve cusp morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03700",
    "question": "What is associated with Fetal intraventricular hemorrhage without ventriculomegaly?",
    "seeds": [
      "Fetal intraventricular hemorrhage without ventriculomegaly"
    ],
    "gold_answer": "Abnormal fetal central nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03701",
    "question": "What is associated with Leukoencephalopathy?",
    "seeds": [
      "Leukoencephalopathy"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03702",
    "question": "What phenotype is associated with Monocyte chemotactic disorder?",
    "seeds": [
      "Monocyte chemotactic disorder"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03703",
    "question": "What is associated with Abnormal motor nerve conduction velocity?",
    "seeds": [
      "Abnormal motor nerve conduction velocity"
    ],
    "gold_answer": "Abnormal nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03704",
    "question": "What phenotype is associated with Aganglionosis, total intestinal?",
    "seeds": [
      "Aganglionosis, total intestinal"
    ],
    "gold_answer": "Total intestinal aganglionosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03705",
    "question": "What is associated with Tubo-ovarian abscess?",
    "seeds": [
      "Tubo-ovarian abscess"
    ],
    "gold_answer": "Abnormal peritoneum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03706",
    "question": "What is associated with Thin toenail?",
    "seeds": [
      "Thin toenail"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03707",
    "question": "What is associated with Urinary retention?",
    "seeds": [
      "Urinary retention"
    ],
    "gold_answer": "Abnormality of the lower urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03708",
    "question": "What is associated with Mucopolysaccharidosis type 6, slowly progressing?",
    "seeds": [
      "Mucopolysaccharidosis type 6, slowly progressing"
    ],
    "gold_answer": "ARSB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03709",
    "question": "What is associated with Chronic gastritis?",
    "seeds": [
      "Chronic gastritis"
    ],
    "gold_answer": "Abnormal gastric mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03710",
    "question": "What is associated with Hernia?",
    "seeds": [
      "Hernia"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03711",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 43?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 43"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03712",
    "question": "What is associated with Visual snow syndrome?",
    "seeds": [
      "Visual snow syndrome"
    ],
    "gold_answer": "Headache",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03713",
    "question": "What phenotype is associated with Autoinflammation with infantile enterocolitis?",
    "seeds": [
      "Autoinflammation with infantile enterocolitis"
    ],
    "gold_answer": "Hypofibrinogenemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03714",
    "question": "What is associated with Abnormal CSF methionine concentration?",
    "seeds": [
      "Abnormal CSF methionine concentration"
    ],
    "gold_answer": "Abnormal CSF aspartate family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03715",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 69?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 69"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03716",
    "question": "What is associated with Focal aware cognitive seizure with dyscalculia/acalculia?",
    "seeds": [
      "Focal aware cognitive seizure with dyscalculia/acalculia"
    ],
    "gold_answer": "Focal cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03717",
    "question": "What is associated with Osteolytic defects of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Osteolytic defects of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal distal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03718",
    "question": "What is associated with Rectal polyposis?",
    "seeds": [
      "Rectal polyposis"
    ],
    "gold_answer": "Large intestinal polyposis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03719",
    "question": "What is associated with Renal tubular epithelial cell hemosiderin?",
    "seeds": [
      "Renal tubular epithelial cell hemosiderin"
    ],
    "gold_answer": "Abnormal renal tubular epithelial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03720",
    "question": "What is associated with Midsystolic murmur?",
    "seeds": [
      "Midsystolic murmur"
    ],
    "gold_answer": "Systolic heart murmur",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03721",
    "question": "What is associated with Abnormal abdomen morphology?",
    "seeds": [
      "Abnormal abdomen morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03722",
    "question": "What phenotype is associated with Syntelencephaly?",
    "seeds": [
      "Syntelencephaly"
    ],
    "gold_answer": "Respiratory distress",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03723",
    "question": "What is associated with Scleromyxedema?",
    "seeds": [
      "Scleromyxedema"
    ],
    "gold_answer": "Azotemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03724",
    "question": "What phenotype is associated with CHIME syndrome?",
    "seeds": [
      "CHIME syndrome"
    ],
    "gold_answer": "Aplastic clavicles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03725",
    "question": "What is associated with Generalized myoclonic-tonic-clonic seizure?",
    "seeds": [
      "Generalized myoclonic-tonic-clonic seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03726",
    "question": "What is associated with Decreased CSF creatinine concentration?",
    "seeds": [
      "Decreased CSF creatinine concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03727",
    "question": "What is associated with Osteopetrosis, autosomal dominant 3?",
    "seeds": [
      "Osteopetrosis, autosomal dominant 3"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03728",
    "question": "What is associated with Statin exposure?",
    "seeds": [
      "Statin exposure"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03729",
    "question": "What is associated with Tubular shadows?",
    "seeds": [
      "Tubular shadows"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03730",
    "question": "What is associated with Congenital adrenal hypoplasia?",
    "seeds": [
      "Congenital adrenal hypoplasia"
    ],
    "gold_answer": "Abnormal endocrine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03731",
    "question": "What is associated with Atrial fibrillation, familial, 14?",
    "seeds": [
      "Atrial fibrillation, familial, 14"
    ],
    "gold_answer": "Atrial arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03732",
    "question": "What phenotype is associated with Posterior cortical atrophy?",
    "seeds": [
      "Posterior cortical atrophy"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03733",
    "question": "What is associated with Glomerular C3 deposition?",
    "seeds": [
      "Glomerular C3 deposition"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03734",
    "question": "What is associated with Prolonged retraction of penile foreskin?",
    "seeds": [
      "Prolonged retraction of penile foreskin"
    ],
    "gold_answer": "Recent past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03735",
    "question": "What is associated with Ocular hypertension?",
    "seeds": [
      "Ocular hypertension"
    ],
    "gold_answer": "Abnormal intraocular pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03736",
    "question": "What is associated with Reduced fetal femur/foot length ratio?",
    "seeds": [
      "Reduced fetal femur/foot length ratio"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03737",
    "question": "What is associated with Deafness, X-linked 4?",
    "seeds": [
      "Deafness, X-linked 4"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03738",
    "question": "What is associated with Punding?",
    "seeds": [
      "Punding"
    ],
    "gold_answer": "Restricted or repetitive behaviors or interests",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03739",
    "question": "What phenotype is associated with Insect stings, hypersensitivity to?",
    "seeds": [
      "Insect stings, hypersensitivity to"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03740",
    "question": "What is associated with Lipodystrophy-intellectual disability-deafness syndrome?",
    "seeds": [
      "Lipodystrophy-intellectual disability-deafness syndrome"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03741",
    "question": "What is associated with Abnormal glucagon level?",
    "seeds": [
      "Abnormal glucagon level"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03742",
    "question": "What is associated with Abnormal CSF lysine concentration?",
    "seeds": [
      "Abnormal CSF lysine concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03743",
    "question": "What is associated with Progressive vitiligo?",
    "seeds": [
      "Progressive vitiligo"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03744",
    "question": "What is associated with Abnormal immunoglobulin level in body fluid?",
    "seeds": [
      "Abnormal immunoglobulin level in body fluid"
    ],
    "gold_answer": "Abnormal leukocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03745",
    "question": "What phenotype is associated with Myelolymphatic insufficiency?",
    "seeds": [
      "Myelolymphatic insufficiency"
    ],
    "gold_answer": "Recurrent bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03746",
    "question": "What phenotype is associated with Severe combined immunodeficiency, X-linked?",
    "seeds": [
      "Severe combined immunodeficiency, X-linked"
    ],
    "gold_answer": "Abnormal fingernail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03747",
    "question": "What is associated with Developmental and epileptic encephalopathy 8?",
    "seeds": [
      "Developmental and epileptic encephalopathy 8"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03748",
    "question": "What is associated with Tessadori-van Haaften neurodevelopmental syndrome 2?",
    "seeds": [
      "Tessadori-van Haaften neurodevelopmental syndrome 2"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03749",
    "question": "What is associated with Leber optic atrophy and dystonia?",
    "seeds": [
      "Leber optic atrophy and dystonia"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03750",
    "question": "What is associated with Rudimentary fibula?",
    "seeds": [
      "Rudimentary fibula"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03751",
    "question": "What is associated with Spermatogenic failure 37?",
    "seeds": [
      "Spermatogenic failure 37"
    ],
    "gold_answer": "Abnormal sperm physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03752",
    "question": "What is associated with IgM heavy chain paraproteinemia?",
    "seeds": [
      "IgM heavy chain paraproteinemia"
    ],
    "gold_answer": "Increased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03753",
    "question": "What is associated with Brachial plexus neuropathy?",
    "seeds": [
      "Brachial plexus neuropathy"
    ],
    "gold_answer": "Abnormality of somatic nerve plexus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03754",
    "question": "What is associated with Groin pain?",
    "seeds": [
      "Groin pain"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03755",
    "question": "What is associated with Ambiguous genitalia, female?",
    "seeds": [
      "Ambiguous genitalia, female"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03756",
    "question": "What is associated with Granular casts?",
    "seeds": [
      "Granular casts"
    ],
    "gold_answer": "Cylindruria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03757",
    "question": "What is associated with Premature ovarian failure 23?",
    "seeds": [
      "Premature ovarian failure 23"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03758",
    "question": "What is associated with Ameliorated by oral zinc supplementation?",
    "seeds": [
      "Ameliorated by oral zinc supplementation"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03759",
    "question": "What is associated with Fragmented epiphyses?",
    "seeds": [
      "Fragmented epiphyses"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03760",
    "question": "What is associated with Abnormal axial skeleton morphology?",
    "seeds": [
      "Abnormal axial skeleton morphology"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03761",
    "question": "What phenotype is associated with Nuchal bleb, familial?",
    "seeds": [
      "Nuchal bleb, familial"
    ],
    "gold_answer": "Hydrops fetalis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03762",
    "question": "What is associated with Abnormal circulating tyrosine concentration?",
    "seeds": [
      "Abnormal circulating tyrosine concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03763",
    "question": "What is associated with Male infertility?",
    "seeds": [
      "Male infertility"
    ],
    "gold_answer": "Infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03764",
    "question": "What is associated with Valgus instability of the elbow?",
    "seeds": [
      "Valgus instability of the elbow"
    ],
    "gold_answer": "Elbow instability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03765",
    "question": "What is associated with Female-limited expression?",
    "seeds": [
      "Female-limited expression"
    ],
    "gold_answer": "Inheritance qualifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03766",
    "question": "What is associated with Small epiphysis of the distal phalanx of the 2nd finger?",
    "seeds": [
      "Small epiphysis of the distal phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03767",
    "question": "What is associated with Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome?",
    "seeds": [
      "Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome"
    ],
    "gold_answer": "Sudden death",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03768",
    "question": "What is associated with Absent cervical vertebra?",
    "seeds": [
      "Absent cervical vertebra"
    ],
    "gold_answer": "Absent vertebra",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03769",
    "question": "What is associated with Ventricular arrhythmia?",
    "seeds": [
      "Ventricular arrhythmia"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03770",
    "question": "What phenotype is associated with Lathosterolosis?",
    "seeds": [
      "Lathosterolosis"
    ],
    "gold_answer": "Hyperbilirubinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03771",
    "question": "What is associated with Abnormal nail surface?",
    "seeds": [
      "Abnormal nail surface"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03772",
    "question": "What is associated with Dysmenorrhea?",
    "seeds": [
      "Dysmenorrhea"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03773",
    "question": "What is associated with Plectin-related limb-girdle muscular dystrophy R17?",
    "seeds": [
      "Plectin-related limb-girdle muscular dystrophy R17"
    ],
    "gold_answer": "Abnormal tendon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03774",
    "question": "What is associated with Leber congenital amaurosis?",
    "seeds": [
      "Leber congenital amaurosis"
    ],
    "gold_answer": "Abnormal pupillary function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03775",
    "question": "What is associated with Lactescent serum?",
    "seeds": [
      "Lactescent serum"
    ],
    "gold_answer": "Hyperlipidemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03776",
    "question": "What is associated with Abnormality of the orbital region?",
    "seeds": [
      "Abnormality of the orbital region"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03777",
    "question": "What is associated with Anti-signal recognition particle antibody positivity?",
    "seeds": [
      "Anti-signal recognition particle antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03778",
    "question": "What is associated with Arcuate intimal/medial venulitis?",
    "seeds": [
      "Arcuate intimal/medial venulitis"
    ],
    "gold_answer": "Abnormal arcuate vein intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03779",
    "question": "What is associated with Late onset atopic dermatitis?",
    "seeds": [
      "Late onset atopic dermatitis"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03780",
    "question": "What is associated with Persistent falcine venous sinus?",
    "seeds": [
      "Persistent falcine venous sinus"
    ],
    "gold_answer": "Abnormal cerebral vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03781",
    "question": "What is associated with Congenital foot contraction deformities?",
    "seeds": [
      "Congenital foot contraction deformities"
    ],
    "gold_answer": "Flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03782",
    "question": "What is associated with Localized pulmonary hemorrhage?",
    "seeds": [
      "Localized pulmonary hemorrhage"
    ],
    "gold_answer": "Abnormality of blood circulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03783",
    "question": "What is associated with Vocal cord paralysis and ptosis?",
    "seeds": [
      "Vocal cord paralysis and ptosis"
    ],
    "gold_answer": "Abnormality of the voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03784",
    "question": "What is associated with Abnormal urine output?",
    "seeds": [
      "Abnormal urine output"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03785",
    "question": "What is associated with Thoracolumbar scoliosis?",
    "seeds": [
      "Thoracolumbar scoliosis"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03786",
    "question": "What is associated with Polyembryoma?",
    "seeds": [
      "Polyembryoma"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03787",
    "question": "What is associated with Sclerotic vertebral endplates?",
    "seeds": [
      "Sclerotic vertebral endplates"
    ],
    "gold_answer": "Abnormality of the vertebral endplates",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03788",
    "question": "What is associated with Reduced proximal interphalangeal joint space?",
    "seeds": [
      "Reduced proximal interphalangeal joint space"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03789",
    "question": "What is associated with Absent coronary sinus?",
    "seeds": [
      "Absent coronary sinus"
    ],
    "gold_answer": "Abnormal cardiac atrium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03790",
    "question": "What is associated with Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease?",
    "seeds": [
      "Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease"
    ],
    "gold_answer": "TNNI3K",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03791",
    "question": "What is associated with Hereditary persistence of fetal hemoglobin-intellectual disability syndrome?",
    "seeds": [
      "Hereditary persistence of fetal hemoglobin-intellectual disability syndrome"
    ],
    "gold_answer": "BCL11A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03792",
    "question": "What phenotype is associated with Proximal 5th toe symphalangism?",
    "seeds": [
      "Proximal 5th toe symphalangism"
    ],
    "gold_answer": "Elbow ankylosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03793",
    "question": "What phenotype is associated with Warburg micro syndrome 3?",
    "seeds": [
      "Warburg micro syndrome 3"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03794",
    "question": "What is associated with Congruous homonymous hemianopia?",
    "seeds": [
      "Congruous homonymous hemianopia"
    ],
    "gold_answer": "Hemianopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03795",
    "question": "What is associated with Elevated erythrocyte galactose-1-phosphate concentration?",
    "seeds": [
      "Elevated erythrocyte galactose-1-phosphate concentration"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03796",
    "question": "What is associated with Abnormal foveal morphology on macular OCT?",
    "seeds": [
      "Abnormal foveal morphology on macular OCT"
    ],
    "gold_answer": "Abnormal posterior segment imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03797",
    "question": "What is associated with Charcot-Marie-Tooth disease, recessive intermediate A?",
    "seeds": [
      "Charcot-Marie-Tooth disease, recessive intermediate A"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03798",
    "question": "What is associated with N-acetylaspartate deficiency?",
    "seeds": [
      "N-acetylaspartate deficiency"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03799",
    "question": "What is associated with Enlarged peroxisomes?",
    "seeds": [
      "Enlarged peroxisomes"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03800",
    "question": "What is associated with Pancreatitis, hereditary?",
    "seeds": [
      "Pancreatitis, hereditary"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03801",
    "question": "What is associated with Fractured distal tarsal bone 2?",
    "seeds": [
      "Fractured distal tarsal bone 2"
    ],
    "gold_answer": "Abnormality of the tarsal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03802",
    "question": "What is associated with Dahlberg-Borer-Newcomer syndrome?",
    "seeds": [
      "Dahlberg-Borer-Newcomer syndrome"
    ],
    "gold_answer": "Abnormality of the parathyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03803",
    "question": "What phenotype is associated with Leukodystrophy, hypomyelinating, 24?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 24"
    ],
    "gold_answer": "Ventriculomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03804",
    "question": "What is associated with Focal impaired awareness motor seizure with negative myoclonus?",
    "seeds": [
      "Focal impaired awareness motor seizure with negative myoclonus"
    ],
    "gold_answer": "Dialeptic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03805",
    "question": "What is associated with Osteogenesis imperfecta type 2?",
    "seeds": [
      "Osteogenesis imperfecta type 2"
    ],
    "gold_answer": "P3H1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03806",
    "question": "What is associated with Nasolacrimal sac papilloma?",
    "seeds": [
      "Nasolacrimal sac papilloma"
    ],
    "gold_answer": "Nasolacrimal sac obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03807",
    "question": "What is associated with Staring gaze?",
    "seeds": [
      "Staring gaze"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03808",
    "question": "What is associated with Biceps areflexia?",
    "seeds": [
      "Biceps areflexia"
    ],
    "gold_answer": "Areflexia of upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03809",
    "question": "What is associated with Reduced leukocyte arylsulfatase A activity?",
    "seeds": [
      "Reduced leukocyte arylsulfatase A activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03810",
    "question": "What is associated with Abnormal atrioventricular connection?",
    "seeds": [
      "Abnormal atrioventricular connection"
    ],
    "gold_answer": "Abnormal connection of the cardiac segments",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03811",
    "question": "What is associated with Anomalous rib insertion to vertebrae?",
    "seeds": [
      "Anomalous rib insertion to vertebrae"
    ],
    "gold_answer": "Abnormal rib morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03812",
    "question": "What is associated with Accessory ectopic thyroid tissue?",
    "seeds": [
      "Accessory ectopic thyroid tissue"
    ],
    "gold_answer": "Ectopic thyroid",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03813",
    "question": "What phenotype is associated with Xq12-q13.3 duplication syndrome?",
    "seeds": [
      "Xq12-q13.3 duplication syndrome"
    ],
    "gold_answer": "Cleft earlobe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03814",
    "question": "What is associated with Congenital malformation of the great arteries?",
    "seeds": [
      "Congenital malformation of the great arteries"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03815",
    "question": "What is associated with 1-minute APGAR score of 4?",
    "seeds": [
      "1-minute APGAR score of 4"
    ],
    "gold_answer": "Low 1-minute APGAR score",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03816",
    "question": "What is associated with Hypoplastic right ventricle?",
    "seeds": [
      "Hypoplastic right ventricle"
    ],
    "gold_answer": "Congenital malformation of the right heart",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03817",
    "question": "What is associated with Bronchial hemorrhage?",
    "seeds": [
      "Bronchial hemorrhage"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03818",
    "question": "What is associated with Hypervalinemia?",
    "seeds": [
      "Hypervalinemia"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03819",
    "question": "What is associated with Reduced erythrocyte porphobilinogen deaminase activity?",
    "seeds": [
      "Reduced erythrocyte porphobilinogen deaminase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03820",
    "question": "What is associated with Atrial situs ambiguous?",
    "seeds": [
      "Atrial situs ambiguous"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03821",
    "question": "What is associated with Retropharyngeal hemangioma?",
    "seeds": [
      "Retropharyngeal hemangioma"
    ],
    "gold_answer": "Vascular neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03822",
    "question": "What is associated with Abnormality of iron homeostasis?",
    "seeds": [
      "Abnormality of iron homeostasis"
    ],
    "gold_answer": "Abnormal blood ion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03823",
    "question": "What is associated with Pediculosis capitis?",
    "seeds": [
      "Pediculosis capitis"
    ],
    "gold_answer": "Positive skin infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03824",
    "question": "What is associated with Reduced total lung capacity?",
    "seeds": [
      "Reduced total lung capacity"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03825",
    "question": "What is associated with Hodgkin morphology cells?",
    "seeds": [
      "Hodgkin morphology cells"
    ],
    "gold_answer": "Abnormal lymph-node biospecimen",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03826",
    "question": "What is associated with Postorgasmic illness syndrome?",
    "seeds": [
      "Postorgasmic illness syndrome"
    ],
    "gold_answer": "Abnormality of skin adnexa physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03827",
    "question": "What is associated with Subcortical U fiber lesion?",
    "seeds": [
      "Subcortical U fiber lesion"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03828",
    "question": "What is associated with Impaired binding of factor VIII to VWF?",
    "seeds": [
      "Impaired binding of factor VIII to VWF"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03829",
    "question": "What is associated with Fatty casts?",
    "seeds": [
      "Fatty casts"
    ],
    "gold_answer": "Acellular urinary casts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03830",
    "question": "What is associated with SETD2-related microcephaly-severe intellectual disability-multiple congenital anomalies syndrome?",
    "seeds": [
      "SETD2-related microcephaly-severe intellectual disability-multiple congenital anomalies syndrome"
    ],
    "gold_answer": "SETD2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03831",
    "question": "What is associated with Decreased adipose tissue around neck?",
    "seeds": [
      "Decreased adipose tissue around neck"
    ],
    "gold_answer": "Decreased adipose tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03832",
    "question": "What is associated with Dyskeratosis congenita, autosomal recessive 8?",
    "seeds": [
      "Dyskeratosis congenita, autosomal recessive 8"
    ],
    "gold_answer": "Abnormality of the scalp hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03833",
    "question": "What is associated with Reflex tearing?",
    "seeds": [
      "Reflex tearing"
    ],
    "gold_answer": "Epiphora",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03834",
    "question": "What is associated with Polycystic kidney disease 7?",
    "seeds": [
      "Polycystic kidney disease 7"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03835",
    "question": "What is associated with Aortic aneurysm, abdominal?",
    "seeds": [
      "Aortic aneurysm, abdominal"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03836",
    "question": "What is associated with Phenotypic abnormality?",
    "seeds": [
      "Phenotypic abnormality"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03837",
    "question": "What is associated with Acth deficiency, isolated?",
    "seeds": [
      "Acth deficiency, isolated"
    ],
    "gold_answer": "Abnormality of circulating cortisol level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03838",
    "question": "What is associated with Skin pit?",
    "seeds": [
      "Skin pit"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03839",
    "question": "What is associated with EEG with focal spike waves?",
    "seeds": [
      "EEG with focal spike waves"
    ],
    "gold_answer": "EEG with focal epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03840",
    "question": "What is associated with Dilatation of celiac artery?",
    "seeds": [
      "Dilatation of celiac artery"
    ],
    "gold_answer": "Dilatation of an abdominal artery",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03841",
    "question": "What is associated with Epidermolysis bullosa, junctional 2A, intermediate?",
    "seeds": [
      "Epidermolysis bullosa, junctional 2A, intermediate"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03842",
    "question": "What is associated with Developmental and epileptic encephalopathy 89?",
    "seeds": [
      "Developmental and epileptic encephalopathy 89"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03843",
    "question": "What is associated with Lower limb dysmetria?",
    "seeds": [
      "Lower limb dysmetria"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03844",
    "question": "What is associated with Ventricular hypertrophy?",
    "seeds": [
      "Ventricular hypertrophy"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03845",
    "question": "What is associated with Peroxisome biogenesis disorder 6B?",
    "seeds": [
      "Peroxisome biogenesis disorder 6B"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03846",
    "question": "What is associated with Duodenal atresia?",
    "seeds": [
      "Duodenal atresia"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03847",
    "question": "What is associated with Bullet-shaped distal phalanx of the 2nd toe?",
    "seeds": [
      "Bullet-shaped distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal second toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03848",
    "question": "What is associated with Abnormally straight spine?",
    "seeds": [
      "Abnormally straight spine"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03849",
    "question": "What is associated with Elevated urinary N-carbamyl-beta-aminoisobutyric acid level?",
    "seeds": [
      "Elevated urinary N-carbamyl-beta-aminoisobutyric acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03850",
    "question": "What is associated with Organized thrombi within interlobular vein lumen?",
    "seeds": [
      "Organized thrombi within interlobular vein lumen"
    ],
    "gold_answer": "Abnormal intrarenal vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03851",
    "question": "What is associated with Transposition of the great arteries, dextro-looped 1?",
    "seeds": [
      "Transposition of the great arteries, dextro-looped 1"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03852",
    "question": "What is associated with Absent hand?",
    "seeds": [
      "Absent hand"
    ],
    "gold_answer": "Transverse terminal limb defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03853",
    "question": "What is associated with Hypertelorism-hypospadias-polysyndactyly syndrome?",
    "seeds": [
      "Hypertelorism-hypospadias-polysyndactyly syndrome"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03854",
    "question": "What is associated with Rhizomelic chondrodysplasia punctata type 5?",
    "seeds": [
      "Rhizomelic chondrodysplasia punctata type 5"
    ],
    "gold_answer": "PEX5",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_03855",
    "question": "What is associated with Onychoheterotopia?",
    "seeds": [
      "Onychoheterotopia"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03856",
    "question": "What is associated with Absent in utero ossification of vertebral bodies?",
    "seeds": [
      "Absent in utero ossification of vertebral bodies"
    ],
    "gold_answer": "Abnormally ossified vertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03857",
    "question": "What is associated with Abnormal oral morphology?",
    "seeds": [
      "Abnormal oral morphology"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03858",
    "question": "What is associated with Deafness, autosomal recessive 18B?",
    "seeds": [
      "Deafness, autosomal recessive 18B"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03859",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 35?",
    "seeds": [
      "Ciliary dyskinesia, primary, 35"
    ],
    "gold_answer": "Meckel diverticulum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03860",
    "question": "What is associated with Pain at the lateral aspect of the knee?",
    "seeds": [
      "Pain at the lateral aspect of the knee"
    ],
    "gold_answer": "Lower limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03861",
    "question": "What is associated with Amyloidosis, hereditary systemic 5?",
    "seeds": [
      "Amyloidosis, hereditary systemic 5"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03862",
    "question": "What is associated with Aggressive systemic mastocytosis?",
    "seeds": [
      "Aggressive systemic mastocytosis"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03863",
    "question": "What is associated with Maternal hypertension?",
    "seeds": [
      "Maternal hypertension"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03864",
    "question": "What is associated with Anterior segment dysgenesis 1?",
    "seeds": [
      "Anterior segment dysgenesis 1"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03865",
    "question": "What is associated with Reduced cystathionine beta-synthase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced cystathionine beta-synthase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03866",
    "question": "What phenotype is associated with COASY protein-associated neurodegeneration?",
    "seeds": [
      "COASY protein-associated neurodegeneration"
    ],
    "gold_answer": "Cognitive impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03867",
    "question": "What is associated with Digital constriction ring?",
    "seeds": [
      "Digital constriction ring"
    ],
    "gold_answer": "Abnormal placental membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03868",
    "question": "What is associated with Hemiplegia/hemiparesis?",
    "seeds": [
      "Hemiplegia/hemiparesis"
    ],
    "gold_answer": "Weakness due to upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03869",
    "question": "What is associated with Chronic neutrophilic leukemia?",
    "seeds": [
      "Chronic neutrophilic leukemia"
    ],
    "gold_answer": "CSF3R",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03870",
    "question": "What is associated with Vaginal stricture?",
    "seeds": [
      "Vaginal stricture"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03871",
    "question": "What is associated with Renal lymphocytic tubulitis?",
    "seeds": [
      "Renal lymphocytic tubulitis"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03872",
    "question": "What is associated with X-linked intellectual disability due to GRIA3 mutations?",
    "seeds": [
      "X-linked intellectual disability due to GRIA3 mutations"
    ],
    "gold_answer": "Abnormality of facial soft tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03873",
    "question": "What is associated with Abnormal cerebellar cortex morphology?",
    "seeds": [
      "Abnormal cerebellar cortex morphology"
    ],
    "gold_answer": "Abnormal hindbrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03874",
    "question": "What is associated with Hypoplasia of the frontal bone?",
    "seeds": [
      "Hypoplasia of the frontal bone"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03875",
    "question": "What is associated with Fanconi renotubular syndrome 1?",
    "seeds": [
      "Fanconi renotubular syndrome 1"
    ],
    "gold_answer": "Abnormality of alkaline phosphatase level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03876",
    "question": "What is associated with Increased anti-fungi IgE antibody level?",
    "seeds": [
      "Increased anti-fungi IgE antibody level"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03877",
    "question": "What is associated with 2-4 toe syndactyly?",
    "seeds": [
      "2-4 toe syndactyly"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03878",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 14?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 14"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03879",
    "question": "What is associated with Episodic ataxia, type 6?",
    "seeds": [
      "Episodic ataxia, type 6"
    ],
    "gold_answer": "Auditory hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03880",
    "question": "What is associated with Duplication of the proximal phalanx of hand?",
    "seeds": [
      "Duplication of the proximal phalanx of hand"
    ],
    "gold_answer": "Duplication of bones involving the upper extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03881",
    "question": "What is associated with Increased lymph-node cellular CD19 expression?",
    "seeds": [
      "Increased lymph-node cellular CD19 expression"
    ],
    "gold_answer": "Abnormal level of lymph-node cellular CD19 expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03882",
    "question": "What phenotype is associated with Aganglionosis, total intestinal?",
    "seeds": [
      "Aganglionosis, total intestinal"
    ],
    "gold_answer": "Total intestinal aganglionosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03883",
    "question": "What is associated with Intrahepatic cholestasis with episodic jaundice?",
    "seeds": [
      "Intrahepatic cholestasis with episodic jaundice"
    ],
    "gold_answer": "Abnormal hepatobiliary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03884",
    "question": "What is associated with Pulmonary Langerhans cell histiocytosis?",
    "seeds": [
      "Pulmonary Langerhans cell histiocytosis"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03885",
    "question": "What is associated with Delivery by Odon device?",
    "seeds": [
      "Delivery by Odon device"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03886",
    "question": "What is associated with Renal medullary interstitial inflammation?",
    "seeds": [
      "Renal medullary interstitial inflammation"
    ],
    "gold_answer": "Renal interstitial inflammation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03887",
    "question": "What is associated with Arteriovenous malformation?",
    "seeds": [
      "Arteriovenous malformation"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03888",
    "question": "What is associated with Increased circulating iron concentration?",
    "seeds": [
      "Increased circulating iron concentration"
    ],
    "gold_answer": "Abnormality of iron homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03889",
    "question": "What is associated with Pressure-induced localized lipoatrophy?",
    "seeds": [
      "Pressure-induced localized lipoatrophy"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03890",
    "question": "What is associated with FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 5?",
    "seeds": [
      "FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 5"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03891",
    "question": "What is associated with Methionine malabsorption syndrome?",
    "seeds": [
      "Methionine malabsorption syndrome"
    ],
    "gold_answer": "Hypopigmentation of hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03892",
    "question": "What phenotype is associated with Noonan syndrome 9?",
    "seeds": [
      "Noonan syndrome 9"
    ],
    "gold_answer": "Hypoplastic aortic arch",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03893",
    "question": "What is associated with Absent foot?",
    "seeds": [
      "Absent foot"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03894",
    "question": "What is associated with Increased circulating creatine kinase MM isoform?",
    "seeds": [
      "Increased circulating creatine kinase MM isoform"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03895",
    "question": "What is associated with Short REM sleep?",
    "seeds": [
      "Short REM sleep"
    ],
    "gold_answer": "Abnormal sleep architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03896",
    "question": "What is associated with Accessory spleen?",
    "seeds": [
      "Accessory spleen"
    ],
    "gold_answer": "Supernumerary spleens",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03897",
    "question": "What is associated with Apnea, obstructive sleep?",
    "seeds": [
      "Apnea, obstructive sleep"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03898",
    "question": "What is associated with Increased CSF homocarnosine concentration?",
    "seeds": [
      "Increased CSF homocarnosine concentration"
    ],
    "gold_answer": "Abnormal CSF homocarnosine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03899",
    "question": "What is associated with Fibrillar glomerular subepithelial deposits?",
    "seeds": [
      "Fibrillar glomerular subepithelial deposits"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03900",
    "question": "What is associated with Intellectual developmental disorder, X-linked 109?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 109"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03901",
    "question": "What is associated with Renal tubulopathy-encephalopathy-liver failure syndrome?",
    "seeds": [
      "Renal tubulopathy-encephalopathy-liver failure syndrome"
    ],
    "gold_answer": "BCS1L",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03902",
    "question": "What is associated with Refractory drug response?",
    "seeds": [
      "Refractory drug response"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03903",
    "question": "What is associated with Acrodysostosis 2 with or without hormone resistance?",
    "seeds": [
      "Acrodysostosis 2 with or without hormone resistance"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03904",
    "question": "What is associated with Ileal stricture?",
    "seeds": [
      "Ileal stricture"
    ],
    "gold_answer": "Abnormal ileum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03905",
    "question": "What is associated with Radial deviation of the 3rd finger?",
    "seeds": [
      "Radial deviation of the 3rd finger"
    ],
    "gold_answer": "Abnormal 3rd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03906",
    "question": "What is associated with Stapes ankylosis?",
    "seeds": [
      "Stapes ankylosis"
    ],
    "gold_answer": "Abnormal middle ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03907",
    "question": "What is associated with Abnormal circulating biopterin concentration?",
    "seeds": [
      "Abnormal circulating biopterin concentration"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03908",
    "question": "What phenotype is associated with Short-Rib thoracic dysplasia 17 with or without polydactyly?",
    "seeds": [
      "Short-Rib thoracic dysplasia 17 with or without polydactyly"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03909",
    "question": "What is associated with Anti-myelin-associated glycoprotein antibody positivity?",
    "seeds": [
      "Anti-myelin-associated glycoprotein antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03910",
    "question": "What is associated with Developmental delay-overweight-facial dysmorphism-behavioral abnormalities syndrome?",
    "seeds": [
      "Developmental delay-overweight-facial dysmorphism-behavioral abnormalities syndrome"
    ],
    "gold_answer": "SRRM2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_03911",
    "question": "What is associated with Recurrent Haemophilus influenzae infections?",
    "seeds": [
      "Recurrent Haemophilus influenzae infections"
    ],
    "gold_answer": "Recurrent bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03912",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 42?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 42"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03913",
    "question": "What is associated with Focal sensory seizure with cephalic sensation?",
    "seeds": [
      "Focal sensory seizure with cephalic sensation"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03914",
    "question": "What is associated with Congenital sensorineural hearing impairment?",
    "seeds": [
      "Congenital sensorineural hearing impairment"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03915",
    "question": "What is associated with Epilepsy, reading?",
    "seeds": [
      "Epilepsy, reading"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03916",
    "question": "What is associated with Abnormal peripheral action potential amplitude?",
    "seeds": [
      "Abnormal peripheral action potential amplitude"
    ],
    "gold_answer": "Abnormality of peripheral nerve conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03917",
    "question": "What is associated with 2-3 toe syndactyly?",
    "seeds": [
      "2-3 toe syndactyly"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03918",
    "question": "What is associated with Arrhythmogenic right ventricular dysplasia, familial, 13?",
    "seeds": [
      "Arrhythmogenic right ventricular dysplasia, familial, 13"
    ],
    "gold_answer": "Tachycardia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03919",
    "question": "What is associated with Polycythemia?",
    "seeds": [
      "Polycythemia"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03920",
    "question": "What is associated with Remnants of the hyaloid vascular system?",
    "seeds": [
      "Remnants of the hyaloid vascular system"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03921",
    "question": "What is associated with Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3?",
    "seeds": [
      "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3"
    ],
    "gold_answer": "Abnormal scapula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03922",
    "question": "What is associated with Crumpled humerus?",
    "seeds": [
      "Crumpled humerus"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03923",
    "question": "What is associated with Reticular pattern on pulmonary HRCT?",
    "seeds": [
      "Reticular pattern on pulmonary HRCT"
    ],
    "gold_answer": "Pulmonary interstitial high-resolution computed tomography abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03924",
    "question": "What is associated with Abnormal circulating glucose-6-phosphate dehydrogenase concentration?",
    "seeds": [
      "Abnormal circulating glucose-6-phosphate dehydrogenase concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03925",
    "question": "What is associated with Hemangiomas, cavernous, of face and supraumbilical midline raphe?",
    "seeds": [
      "Hemangiomas, cavernous, of face and supraumbilical midline raphe"
    ],
    "gold_answer": "Cavernous hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03926",
    "question": "What is associated with Congenital factor X deficiency?",
    "seeds": [
      "Congenital factor X deficiency"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03927",
    "question": "What phenotype is associated with Mitochondrial complex III deficiency, nuclear type 1?",
    "seeds": [
      "Mitochondrial complex III deficiency, nuclear type 1"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03928",
    "question": "What is associated with Abnormal olecranon morphology?",
    "seeds": [
      "Abnormal olecranon morphology"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03929",
    "question": "What is associated with Triangular shaped phalanges of the 5th toe?",
    "seeds": [
      "Triangular shaped phalanges of the 5th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03930",
    "question": "What is associated with GABA-transaminase deficiency?",
    "seeds": [
      "GABA-transaminase deficiency"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03931",
    "question": "What is associated with Adult idiopathic neutropenia?",
    "seeds": [
      "Adult idiopathic neutropenia"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03932",
    "question": "What is associated with Gonadotropin deficiency?",
    "seeds": [
      "Gonadotropin deficiency"
    ],
    "gold_answer": "Abnormality of the anterior pituitary",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03933",
    "question": "What is associated with Preretinal hemorrhage?",
    "seeds": [
      "Preretinal hemorrhage"
    ],
    "gold_answer": "Fundus hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03934",
    "question": "What is associated with Camptodactyly with muscular hypoplasia, skeletal dysplasia, and abnormalpalmar creases?",
    "seeds": [
      "Camptodactyly with muscular hypoplasia, skeletal dysplasia, and abnormalpalmar creases"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03935",
    "question": "What phenotype is associated with 20q11.2 microdeletion syndrome?",
    "seeds": [
      "20q11.2 microdeletion syndrome"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03936",
    "question": "What is associated with Stippling of the epiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Stippling of the epiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Epiphyseal stippling of toe phalanges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03937",
    "question": "What is associated with Deviated nasal tip?",
    "seeds": [
      "Deviated nasal tip"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03938",
    "question": "What is associated with Abnormal mesentery morphology?",
    "seeds": [
      "Abnormal mesentery morphology"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03939",
    "question": "What is associated with Wide hamate bone?",
    "seeds": [
      "Wide hamate bone"
    ],
    "gold_answer": "Large hamate bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03940",
    "question": "What is associated with Hashimoto thyroiditis?",
    "seeds": [
      "Hashimoto thyroiditis"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03941",
    "question": "What is associated with Sharp?",
    "seeds": [
      "Sharp"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03942",
    "question": "What is associated with Adrenocortical carcinoma?",
    "seeds": [
      "Adrenocortical carcinoma"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03943",
    "question": "What is associated with Increased proportion of HLA DR+ CD4+ T cells?",
    "seeds": [
      "Increased proportion of HLA DR+ CD4+ T cells"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03944",
    "question": "What is associated with Abnormal unswitched memory B cell proportion?",
    "seeds": [
      "Abnormal unswitched memory B cell proportion"
    ],
    "gold_answer": "Abnormal B cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03945",
    "question": "What is associated with Neurodevelopmental disorder with or without early-onset generalized epilepsy?",
    "seeds": [
      "Neurodevelopmental disorder with or without early-onset generalized epilepsy"
    ],
    "gold_answer": "Reduced attention regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03946",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 1?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 1"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03947",
    "question": "What is associated with Chylous ascites?",
    "seeds": [
      "Chylous ascites"
    ],
    "gold_answer": "Abnormality of pancreas physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03948",
    "question": "What is associated with Autosomal recessive axonal Charcot-Marie-Tooth disease due to copper metabolism defect?",
    "seeds": [
      "Autosomal recessive axonal Charcot-Marie-Tooth disease due to copper metabolism defect"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03949",
    "question": "What phenotype is associated with Basan syndrome?",
    "seeds": [
      "Basan syndrome"
    ],
    "gold_answer": "Epidermal acanthosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03950",
    "question": "What is associated with Hallux sesamoid injury?",
    "seeds": [
      "Hallux sesamoid injury"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03951",
    "question": "What is associated with Metaphyseal chevron deformity?",
    "seeds": [
      "Metaphyseal chevron deformity"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03952",
    "question": "What is associated with Tortuous appearance of the stomach?",
    "seeds": [
      "Tortuous appearance of the stomach"
    ],
    "gold_answer": "Abnormal stomach morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03953",
    "question": "What is associated with Cryoglobulinemia, familial mixed?",
    "seeds": [
      "Cryoglobulinemia, familial mixed"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03954",
    "question": "What is associated with Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development?",
    "seeds": [
      "Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development"
    ],
    "gold_answer": "Abnormality of the philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03955",
    "question": "What is associated with Recurrent lower respiratory tract infections?",
    "seeds": [
      "Recurrent lower respiratory tract infections"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03956",
    "question": "What is associated with Marburg hemorrhagic fever?",
    "seeds": [
      "Marburg hemorrhagic fever"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03957",
    "question": "What is associated with Hypohidrotic ectodermal dysplasia with immunodeficiency?",
    "seeds": [
      "Hypohidrotic ectodermal dysplasia with immunodeficiency"
    ],
    "gold_answer": "Hypohidrosis or hyperhidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03958",
    "question": "What is associated with Calvarial osteosclerosis?",
    "seeds": [
      "Calvarial osteosclerosis"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03959",
    "question": "What is associated with Partial atrioventricular septal defect?",
    "seeds": [
      "Partial atrioventricular septal defect"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03960",
    "question": "What is associated with Nodular-centrilobular without tree-in-bud pattern on pulmonary HRCT?",
    "seeds": [
      "Nodular-centrilobular without tree-in-bud pattern on pulmonary HRCT"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03961",
    "question": "What is associated with Nesidioblastosis?",
    "seeds": [
      "Nesidioblastosis"
    ],
    "gold_answer": "Abnormal pancreas morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03962",
    "question": "What is associated with Dysgyria with normal cortical thickness?",
    "seeds": [
      "Dysgyria with normal cortical thickness"
    ],
    "gold_answer": "Abnormal cortical gyration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03963",
    "question": "What is associated with White hair?",
    "seeds": [
      "White hair"
    ],
    "gold_answer": "Hypopigmentation of hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03964",
    "question": "What is associated with Cerebral degeneration?",
    "seeds": [
      "Cerebral degeneration"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03965",
    "question": "What phenotype is associated with Microcephaly-seizures-intellectual disability-heart disease syndrome?",
    "seeds": [
      "Microcephaly-seizures-intellectual disability-heart disease syndrome"
    ],
    "gold_answer": "Abnormal sternum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03966",
    "question": "What is associated with Carbuncle?",
    "seeds": [
      "Carbuncle"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03967",
    "question": "What phenotype is associated with Hereditary renal hypouricemia?",
    "seeds": [
      "Hereditary renal hypouricemia"
    ],
    "gold_answer": "Decreased glomerular filtration rate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03968",
    "question": "What is associated with Dopa-responsive dystonia due to sepiapterin reductase deficiency?",
    "seeds": [
      "Dopa-responsive dystonia due to sepiapterin reductase deficiency"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03969",
    "question": "What is associated with Bitemporal hemianopia?",
    "seeds": [
      "Bitemporal hemianopia"
    ],
    "gold_answer": "Hemianopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03970",
    "question": "What is associated with Altman type II sacrococcygeal teratoma?",
    "seeds": [
      "Altman type II sacrococcygeal teratoma"
    ],
    "gold_answer": "Abnormal sacrum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03971",
    "question": "What is associated with Night blindness, congenital stationary, autosomal dominant 2?",
    "seeds": [
      "Night blindness, congenital stationary, autosomal dominant 2"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03972",
    "question": "What is associated with Deafness, autosomal recessive 47?",
    "seeds": [
      "Deafness, autosomal recessive 47"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03973",
    "question": "What is associated with Dynein arm defect of respiratory motile cilia?",
    "seeds": [
      "Dynein arm defect of respiratory motile cilia"
    ],
    "gold_answer": "Abnormal respiratory motile cilium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03974",
    "question": "What is associated with Delayed elbow epiphyseal ossification?",
    "seeds": [
      "Delayed elbow epiphyseal ossification"
    ],
    "gold_answer": "Delayed upper limb epiphyseal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03975",
    "question": "What is associated with Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndrome?",
    "seeds": [
      "Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndrome"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03976",
    "question": "What is associated with Abnormal immune system morphology?",
    "seeds": [
      "Abnormal immune system morphology"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03977",
    "question": "What is associated with Schmorl's node?",
    "seeds": [
      "Schmorl's node"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03978",
    "question": "What is associated with Appendicular location?",
    "seeds": [
      "Appendicular location"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03979",
    "question": "What is associated with Craniodigital-intellectual disability syndrome?",
    "seeds": [
      "Craniodigital-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03980",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 57?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 57"
    ],
    "gold_answer": "Difficulty standing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03981",
    "question": "What phenotype is associated with Gastrointestinal stromal tumor?",
    "seeds": [
      "Gastrointestinal stromal tumor"
    ],
    "gold_answer": "Spinal canal stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03982",
    "question": "What is associated with Ridged cranial sutures?",
    "seeds": [
      "Ridged cranial sutures"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03983",
    "question": "What is associated with Anarthria?",
    "seeds": [
      "Anarthria"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03984",
    "question": "What is associated with Abnormal circulating superoxide dismutase activity?",
    "seeds": [
      "Abnormal circulating superoxide dismutase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03985",
    "question": "What is associated with Accumulation of lipid droplets in small-bowel enterocytes?",
    "seeds": [
      "Accumulation of lipid droplets in small-bowel enterocytes"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03986",
    "question": "What is associated with Gigantiform cementoma, familial?",
    "seeds": [
      "Gigantiform cementoma, familial"
    ],
    "gold_answer": "Impacted tooth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03987",
    "question": "What phenotype is associated with Dubowitz syndrome?",
    "seeds": [
      "Dubowitz syndrome"
    ],
    "gold_answer": "Constipation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_03988",
    "question": "What is associated with Decreased delta-aminolevulinate dehydratase activity?",
    "seeds": [
      "Decreased delta-aminolevulinate dehydratase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03989",
    "question": "What is associated with Noonan syndrome?",
    "seeds": [
      "Noonan syndrome"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03990",
    "question": "What is associated with Abnormal respiratory system morphology?",
    "seeds": [
      "Abnormal respiratory system morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03991",
    "question": "What is associated with Yellow fever?",
    "seeds": [
      "Yellow fever"
    ],
    "gold_answer": "Decreased urine output",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03992",
    "question": "What is associated with Amblyopia?",
    "seeds": [
      "Amblyopia"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03993",
    "question": "What is associated with Ventricular bigeminy?",
    "seeds": [
      "Ventricular bigeminy"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03994",
    "question": "What is associated with Testicular ischemia?",
    "seeds": [
      "Testicular ischemia"
    ],
    "gold_answer": "Tissue ischemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03995",
    "question": "What is associated with Keratoconjunctivitis?",
    "seeds": [
      "Keratoconjunctivitis"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03996",
    "question": "What is associated with Aplasia/Hypoplasia of the inner ear?",
    "seeds": [
      "Aplasia/Hypoplasia of the inner ear"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03997",
    "question": "What is associated with Abnormality of corneal size?",
    "seeds": [
      "Abnormality of corneal size"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03998",
    "question": "What is associated with Enuresis, nocturnal, 2?",
    "seeds": [
      "Enuresis, nocturnal, 2"
    ],
    "gold_answer": "Enuresis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_03999",
    "question": "What phenotype is associated with Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome?",
    "seeds": [
      "Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome"
    ],
    "gold_answer": "Micrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04000",
    "question": "What phenotype is associated with Major affective disorder 1?",
    "seeds": [
      "Major affective disorder 1"
    ],
    "gold_answer": "Mania",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04001",
    "question": "What is associated with Multinucleated giant chondrocytes in epiphyseal cartilage?",
    "seeds": [
      "Multinucleated giant chondrocytes in epiphyseal cartilage"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04002",
    "question": "What is associated with Increased CSF lysine concentration?",
    "seeds": [
      "Increased CSF lysine concentration"
    ],
    "gold_answer": "Abnormal CSF aspartate family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04003",
    "question": "What is associated with Decreased circulating serum insulin-like growth factor 1 concentration?",
    "seeds": [
      "Decreased circulating serum insulin-like growth factor 1 concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04004",
    "question": "What is associated with Inferior oblique muscle weakness?",
    "seeds": [
      "Inferior oblique muscle weakness"
    ],
    "gold_answer": "Abnormal extraocular muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04005",
    "question": "What is associated with Adipocyte hypertrophy?",
    "seeds": [
      "Adipocyte hypertrophy"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04006",
    "question": "What phenotype is associated with Autosomal recessive ataxia due to ubiquinone deficiency?",
    "seeds": [
      "Autosomal recessive ataxia due to ubiquinone deficiency"
    ],
    "gold_answer": "Gynecomastia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04007",
    "question": "What is associated with Atrial septal defect 1?",
    "seeds": [
      "Atrial septal defect 1"
    ],
    "gold_answer": "GDF1",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_04008",
    "question": "What is associated with Cone-shaped epiphysis of the distal phalanx of the thumb?",
    "seeds": [
      "Cone-shaped epiphysis of the distal phalanx of the thumb"
    ],
    "gold_answer": "Cone-shaped epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04009",
    "question": "What is associated with Unesterified cholesterol accumulation in cultured fibroblasts?",
    "seeds": [
      "Unesterified cholesterol accumulation in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04010",
    "question": "What is associated with Ambiguous genitalia?",
    "seeds": [
      "Ambiguous genitalia"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04011",
    "question": "What is associated with Retinal astrocytic hamartoma?",
    "seeds": [
      "Retinal astrocytic hamartoma"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04012",
    "question": "What is associated with Primary lateral sclerosis, adult?",
    "seeds": [
      "Primary lateral sclerosis, adult"
    ],
    "gold_answer": "Tetraplegia/tetraparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04013",
    "question": "What phenotype is associated with Spinocerebellar ataxia type 42?",
    "seeds": [
      "Spinocerebellar ataxia type 42"
    ],
    "gold_answer": "Dysphagia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04014",
    "question": "What is associated with Scheie syndrome?",
    "seeds": [
      "Scheie syndrome"
    ],
    "gold_answer": "Eclabion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04015",
    "question": "What is associated with Pinhole visual acuity 0.4 LogMAR?",
    "seeds": [
      "Pinhole visual acuity 0.4 LogMAR"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04016",
    "question": "What is associated with Shashi-Pena syndrome?",
    "seeds": [
      "Shashi-Pena syndrome"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04017",
    "question": "What is associated with Symphalangism, distal, with microdontia, dental pulp stones, and narrowedzygomatic arch?",
    "seeds": [
      "Symphalangism, distal, with microdontia, dental pulp stones, and narrowedzygomatic arch"
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04018",
    "question": "What is associated with Distal amyotrophy?",
    "seeds": [
      "Distal amyotrophy"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04019",
    "question": "What is associated with Spinocerebellar ataxia type 4?",
    "seeds": [
      "Spinocerebellar ataxia type 4"
    ],
    "gold_answer": "Decreased/absent ankle reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04020",
    "question": "What is associated with Congenital unilateral hypoplasia of depressor anguli oris?",
    "seeds": [
      "Congenital unilateral hypoplasia of depressor anguli oris"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04021",
    "question": "What is associated with Bone marrow myeloid vacuolization?",
    "seeds": [
      "Bone marrow myeloid vacuolization"
    ],
    "gold_answer": "Abnormal erythroid lineage cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04022",
    "question": "What is associated with Abnormal heart valve physiology?",
    "seeds": [
      "Abnormal heart valve physiology"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04023",
    "question": "What is associated with Abnormal cortical bone morphology?",
    "seeds": [
      "Abnormal cortical bone morphology"
    ],
    "gold_answer": "Abnormal bone structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04024",
    "question": "What is associated with Abnormality of umbilical vein blood flow?",
    "seeds": [
      "Abnormality of umbilical vein blood flow"
    ],
    "gold_answer": "Abnormal fetal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04025",
    "question": "What is associated with Abnormality of the phalanges of the 4th toe?",
    "seeds": [
      "Abnormality of the phalanges of the 4th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04026",
    "question": "What is associated with Congenital factor VII deficiency?",
    "seeds": [
      "Congenital factor VII deficiency"
    ],
    "gold_answer": "Prolonged bleeding following procedure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04027",
    "question": "What is associated with Osteolytic defects of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Osteolytic defects of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Osteolysis involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04028",
    "question": "What is associated with Eosinophil nuclear hypersegmentation?",
    "seeds": [
      "Eosinophil nuclear hypersegmentation"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04029",
    "question": "What is associated with Abnormal fetal heart outflow tract?",
    "seeds": [
      "Abnormal fetal heart outflow tract"
    ],
    "gold_answer": "Abnormal fetal cardiovascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04030",
    "question": "What is associated with Pseudohypoparathyroidism?",
    "seeds": [
      "Pseudohypoparathyroidism"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04031",
    "question": "What is associated with Decreased urinary metaepinephrine level?",
    "seeds": [
      "Decreased urinary metaepinephrine level"
    ],
    "gold_answer": "Decreased urinary catecholamine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04032",
    "question": "What is associated with Prolonged exposure to axillary pressure?",
    "seeds": [
      "Prolonged exposure to axillary pressure"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04033",
    "question": "What phenotype is associated with Megalencephalic leukoencephalopathy with subcortical cysts 4, remitting?",
    "seeds": [
      "Megalencephalic leukoencephalopathy with subcortical cysts 4, remitting"
    ],
    "gold_answer": "Rigidity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04034",
    "question": "What is associated with Abnormality of the radioulnar joints?",
    "seeds": [
      "Abnormality of the radioulnar joints"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04035",
    "question": "What is associated with Connective tissue nevi?",
    "seeds": [
      "Connective tissue nevi"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04036",
    "question": "What is associated with Unusual fungal infection?",
    "seeds": [
      "Unusual fungal infection"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04037",
    "question": "What is associated with Bifid distal phalanx of the thumb?",
    "seeds": [
      "Bifid distal phalanx of the thumb"
    ],
    "gold_answer": "Duplication of the distal phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04038",
    "question": "What is associated with Positive bloodstream Cysticercosis antigen test?",
    "seeds": [
      "Positive bloodstream Cysticercosis antigen test"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04039",
    "question": "What is associated with Deafness, autosomal dominant 72?",
    "seeds": [
      "Deafness, autosomal dominant 72"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04040",
    "question": "What is associated with Broad long bones?",
    "seeds": [
      "Broad long bones"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04041",
    "question": "What is associated with Generalized bone demineralization?",
    "seeds": [
      "Generalized bone demineralization"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04042",
    "question": "What phenotype is associated with Tetrasomy 9p syndrome?",
    "seeds": [
      "Tetrasomy 9p syndrome"
    ],
    "gold_answer": "Renal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04043",
    "question": "What is associated with Adult-onset night blindness?",
    "seeds": [
      "Adult-onset night blindness"
    ],
    "gold_answer": "Nyctalopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04044",
    "question": "What phenotype is associated with Dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema?",
    "seeds": [
      "Dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema"
    ],
    "gold_answer": "Conjunctival icterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04045",
    "question": "What is associated with Elevated urinary 5-hydroxyhexanoic acid level?",
    "seeds": [
      "Elevated urinary 5-hydroxyhexanoic acid level"
    ],
    "gold_answer": "Abnormal urine carboxylic acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04046",
    "question": "What is associated with Thyrotoxicosis with toxic multinodular goiter?",
    "seeds": [
      "Thyrotoxicosis with toxic multinodular goiter"
    ],
    "gold_answer": "Hyperthyroidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04047",
    "question": "What is associated with Maladaptive fear-related cognitions?",
    "seeds": [
      "Maladaptive fear-related cognitions"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04048",
    "question": "What is associated with Respiratory infections in early life?",
    "seeds": [
      "Respiratory infections in early life"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04049",
    "question": "What is associated with Crusting erythematous dermatitis?",
    "seeds": [
      "Crusting erythematous dermatitis"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04050",
    "question": "What is associated with Turricephaly?",
    "seeds": [
      "Turricephaly"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04051",
    "question": "What is associated with Posttraumatic stress symptom?",
    "seeds": [
      "Posttraumatic stress symptom"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04052",
    "question": "What is associated with Pitt-Hopkins like syndrome 1?",
    "seeds": [
      "Pitt-Hopkins like syndrome 1"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04053",
    "question": "What is associated with Anti-Zikavirus-specific antibody positivity?",
    "seeds": [
      "Anti-Zikavirus-specific antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04054",
    "question": "What is associated with Glomerular deposits?",
    "seeds": [
      "Glomerular deposits"
    ],
    "gold_answer": "Abnormal renal cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04055",
    "question": "What is associated with Nystagmus-induced head nodding?",
    "seeds": [
      "Nystagmus-induced head nodding"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04056",
    "question": "What is associated with Pubic bone dysplasia?",
    "seeds": [
      "Pubic bone dysplasia"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04057",
    "question": "What is associated with Hyperautofluorescent macular lesion?",
    "seeds": [
      "Hyperautofluorescent macular lesion"
    ],
    "gold_answer": "Hyperautofluorescent retinal lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04058",
    "question": "What is associated with Psychotic episodes?",
    "seeds": [
      "Psychotic episodes"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04059",
    "question": "What is associated with Increased susceptibility to fractures?",
    "seeds": [
      "Increased susceptibility to fractures"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04060",
    "question": "What phenotype is associated with Dysplastic cortical hyperostosis, Kozlowski-Tsuruta type?",
    "seeds": [
      "Dysplastic cortical hyperostosis, Kozlowski-Tsuruta type"
    ],
    "gold_answer": "Increased bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04061",
    "question": "What is associated with Decreased serum bile acid concentration?",
    "seeds": [
      "Decreased serum bile acid concentration"
    ],
    "gold_answer": "Abnormal circulating monocarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04062",
    "question": "What is associated with Familial hypocalciuric hypercalcemia?",
    "seeds": [
      "Familial hypocalciuric hypercalcemia"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04063",
    "question": "What is associated with Fetal scalp mass?",
    "seeds": [
      "Fetal scalp mass"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04064",
    "question": "What is associated with Abnormal morphology of right ventricular trabeculae?",
    "seeds": [
      "Abnormal morphology of right ventricular trabeculae"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04065",
    "question": "What is associated with Vitreoretinopathy with phalangeal epiphyseal dysplasia?",
    "seeds": [
      "Vitreoretinopathy with phalangeal epiphyseal dysplasia"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04066",
    "question": "What is associated with Translamellar mucoid extracellular matrix accumulation?",
    "seeds": [
      "Translamellar mucoid extracellular matrix accumulation"
    ],
    "gold_answer": "Mucoid extracellular matrix accumulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04067",
    "question": "What is associated with NYSTAGMUS, VOLUNTARY?",
    "seeds": [
      "NYSTAGMUS, VOLUNTARY"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04068",
    "question": "What is associated with Spermatogenic failure 12?",
    "seeds": [
      "Spermatogenic failure 12"
    ],
    "gold_answer": "Functional abnormality of male internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04069",
    "question": "What is associated with Tachylalia?",
    "seeds": [
      "Tachylalia"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04070",
    "question": "What is associated with Increased circulating creatine kinase BB isoform?",
    "seeds": [
      "Increased circulating creatine kinase BB isoform"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04071",
    "question": "What is associated with Friedreich ataxia?",
    "seeds": [
      "Friedreich ataxia"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04072",
    "question": "What is associated with Abnormal activity of mitochondrial respiratory chain?",
    "seeds": [
      "Abnormal activity of mitochondrial respiratory chain"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04073",
    "question": "What is associated with Areas of hypopigmentation and hyperpigmentation that do not follow Blaschko lines?",
    "seeds": [
      "Areas of hypopigmentation and hyperpigmentation that do not follow Blaschko lines"
    ],
    "gold_answer": "Hyperpigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04074",
    "question": "What is associated with Papillary dermis eosinophilic hyaline material?",
    "seeds": [
      "Papillary dermis eosinophilic hyaline material"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04075",
    "question": "What is associated with Progressive cerebellar ataxia?",
    "seeds": [
      "Progressive cerebellar ataxia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04076",
    "question": "What is associated with Pyriform sperm head?",
    "seeds": [
      "Pyriform sperm head"
    ],
    "gold_answer": "Abnormal male germ cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04077",
    "question": "What is associated with Abnormality of tensor veli palatini muscle?",
    "seeds": [
      "Abnormality of tensor veli palatini muscle"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04078",
    "question": "What is associated with Elevated circulating CCL3 concentration?",
    "seeds": [
      "Elevated circulating CCL3 concentration"
    ],
    "gold_answer": "Abnormal circulating chemokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04079",
    "question": "What is associated with Drug metabolism, altered, CES1-related?",
    "seeds": [
      "Drug metabolism, altered, CES1-related"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04080",
    "question": "What is associated with Neonatal electro-clinical motor seizure with automatism?",
    "seeds": [
      "Neonatal electro-clinical motor seizure with automatism"
    ],
    "gold_answer": "Neonatal seizure with electrographic correlate",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04081",
    "question": "What is associated with 3q29 microduplication syndrome?",
    "seeds": [
      "3q29 microduplication syndrome"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04082",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type IIg?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIg"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04083",
    "question": "What phenotype is associated with Pyloric stenosis, infantile hypertrophic 1?",
    "seeds": [
      "Pyloric stenosis, infantile hypertrophic 1"
    ],
    "gold_answer": "Projectile vomiting",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04084",
    "question": "What is associated with Decreased Arden ratio of electrooculogram?",
    "seeds": [
      "Decreased Arden ratio of electrooculogram"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04085",
    "question": "What is associated with Emery-Dreifuss muscular dystrophy 3, autosomal recessive?",
    "seeds": [
      "Emery-Dreifuss muscular dystrophy 3, autosomal recessive"
    ],
    "gold_answer": "Abnormal LDL cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04086",
    "question": "What is associated with Macroglossia?",
    "seeds": [
      "Macroglossia"
    ],
    "gold_answer": "Abnormal tongue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04087",
    "question": "What is associated with Hemangiopericytoma, malignant?",
    "seeds": [
      "Hemangiopericytoma, malignant"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04088",
    "question": "What is associated with Photopsia?",
    "seeds": [
      "Photopsia"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04089",
    "question": "What is associated with Fractured fused metatarsal bones 2-4?",
    "seeds": [
      "Fractured fused metatarsal bones 2-4"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04090",
    "question": "What is associated with Abnormality of muscle of facial expression?",
    "seeds": [
      "Abnormality of muscle of facial expression"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04091",
    "question": "What is associated with Triangular shaped distal phalanx of the 2nd finger?",
    "seeds": [
      "Triangular shaped distal phalanx of the 2nd finger"
    ],
    "gold_answer": "Triangular shaped phalanges of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04092",
    "question": "What is associated with Premature arteriosclerosis?",
    "seeds": [
      "Premature arteriosclerosis"
    ],
    "gold_answer": "Arteriosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04093",
    "question": "What is associated with Ocular albinism?",
    "seeds": [
      "Ocular albinism"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04094",
    "question": "What is associated with Primary hyperoxaluria type 3?",
    "seeds": [
      "Primary hyperoxaluria type 3"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04095",
    "question": "What is associated with Deviation of the 3rd finger?",
    "seeds": [
      "Deviation of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04096",
    "question": "What is associated with Otofacial neurodevelopmental syndrome?",
    "seeds": [
      "Otofacial neurodevelopmental syndrome"
    ],
    "gold_answer": "Abnormal nasal bridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04097",
    "question": "What is associated with Elevated circulating aspartylglucosamine concentration?",
    "seeds": [
      "Elevated circulating aspartylglucosamine concentration"
    ],
    "gold_answer": "Abnormal circulating non-proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04098",
    "question": "What is associated with Decreased size of the clitoris?",
    "seeds": [
      "Decreased size of the clitoris"
    ],
    "gold_answer": "Abnormal clitoris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04099",
    "question": "What is associated with Dilation of Virchow-Robin spaces?",
    "seeds": [
      "Dilation of Virchow-Robin spaces"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04100",
    "question": "What is associated with Plague?",
    "seeds": [
      "Plague"
    ],
    "gold_answer": "Confusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04101",
    "question": "What is associated with Renal cortical necrosis?",
    "seeds": [
      "Renal cortical necrosis"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04102",
    "question": "What is associated with Coronary artery calcification?",
    "seeds": [
      "Coronary artery calcification"
    ],
    "gold_answer": "Cardiovascular calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04103",
    "question": "What is associated with Muscular dystrophy, limb-girdle, type 2D?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, type 2D"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04104",
    "question": "What phenotype is associated with Sanjad-Sakati syndrome?",
    "seeds": [
      "Sanjad-Sakati syndrome"
    ],
    "gold_answer": "Spinal canal stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04105",
    "question": "What is associated with Complete or near-complete absence of specific antibody response to tetanus vaccine?",
    "seeds": [
      "Complete or near-complete absence of specific antibody response to tetanus vaccine"
    ],
    "gold_answer": "Decreased specific antibody response to protein vaccine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04106",
    "question": "What is associated with Tree-in-bud pattern?",
    "seeds": [
      "Tree-in-bud pattern"
    ],
    "gold_answer": "Abnormal pulmonary thoracic imaging finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04107",
    "question": "What is associated with Fibrosis of extraocular muscles, congenital, 1?",
    "seeds": [
      "Fibrosis of extraocular muscles, congenital, 1"
    ],
    "gold_answer": "Craniofacial dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04108",
    "question": "What is associated with Congenital unilateral hypoplasia of depressor anguli oris?",
    "seeds": [
      "Congenital unilateral hypoplasia of depressor anguli oris"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04109",
    "question": "What is associated with Irregular olecranon?",
    "seeds": [
      "Irregular olecranon"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04110",
    "question": "What is associated with Colorectal cancer, hereditary nonpolyposis, type 2?",
    "seeds": [
      "Colorectal cancer, hereditary nonpolyposis, type 2"
    ],
    "gold_answer": "Neoplasm of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04111",
    "question": "What is associated with Amyloid goiter?",
    "seeds": [
      "Amyloid goiter"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04112",
    "question": "What is associated with Caseous vernix-like desquamation?",
    "seeds": [
      "Caseous vernix-like desquamation"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04113",
    "question": "What is associated with Alveolar ridge overgrowth?",
    "seeds": [
      "Alveolar ridge overgrowth"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04114",
    "question": "What is associated with Reduced maximal inspiratory pressure?",
    "seeds": [
      "Reduced maximal inspiratory pressure"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04115",
    "question": "What is associated with Porokeratosis 9, multiple types?",
    "seeds": [
      "Porokeratosis 9, multiple types"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04116",
    "question": "What is associated with Decreased urinary urate?",
    "seeds": [
      "Decreased urinary urate"
    ],
    "gold_answer": "Abnormality of urinary uric acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04117",
    "question": "What is associated with Lipoma?",
    "seeds": [
      "Lipoma"
    ],
    "gold_answer": "Abnormal adipose tissue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04118",
    "question": "What is associated with Pancreatic cancer?",
    "seeds": [
      "Pancreatic cancer"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04119",
    "question": "What is associated with Anti-GQ1b IgG antibody positivity?",
    "seeds": [
      "Anti-GQ1b IgG antibody positivity"
    ],
    "gold_answer": "Anti-GQ1b antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04120",
    "question": "What is associated with Myotonia?",
    "seeds": [
      "Myotonia"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04121",
    "question": "What is associated with Ehlers-Danlos syndrome, periodontal type, 2?",
    "seeds": [
      "Ehlers-Danlos syndrome, periodontal type, 2"
    ],
    "gold_answer": "TRIP13",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_04122",
    "question": "What is associated with Pallor of dorsal columns of the spinal cord?",
    "seeds": [
      "Pallor of dorsal columns of the spinal cord"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04123",
    "question": "What phenotype is associated with Mitochondrial complex I deficiency, nuclear type 5?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 5"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04124",
    "question": "What is associated with Decreased iduronate sulfatase level?",
    "seeds": [
      "Decreased iduronate sulfatase level"
    ],
    "gold_answer": "Abnormal iduronate sulfatase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04125",
    "question": "What is associated with Porokeratosis?",
    "seeds": [
      "Porokeratosis"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04126",
    "question": "What is associated with Hand monodactyly?",
    "seeds": [
      "Hand monodactyly"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04127",
    "question": "What is associated with Scapuloperoneal syndrome, neurogenic, Kaeser type?",
    "seeds": [
      "Scapuloperoneal syndrome, neurogenic, Kaeser type"
    ],
    "gold_answer": "Abnormal Z disk morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04128",
    "question": "What is associated with Abnormal diminished volition?",
    "seeds": [
      "Abnormal diminished volition"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04129",
    "question": "What is associated with Curved middle phalanx of the 4th toe?",
    "seeds": [
      "Curved middle phalanx of the 4th toe"
    ],
    "gold_answer": "Curved 4th toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04130",
    "question": "What is associated with Immunodeficiency 134 (Epstein-Barr virus-specific)?",
    "seeds": [
      "Immunodeficiency 134 (Epstein-Barr virus-specific)"
    ],
    "gold_answer": "Abnormal CD4+ memory T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04131",
    "question": "What is associated with Abnormal metacarpal ossification?",
    "seeds": [
      "Abnormal metacarpal ossification"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04132",
    "question": "What phenotype is associated with Lateral meningocele syndrome?",
    "seeds": [
      "Lateral meningocele syndrome"
    ],
    "gold_answer": "Intestinal atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04133",
    "question": "What is associated with Broad proximal phalanx of toe?",
    "seeds": [
      "Broad proximal phalanx of toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04134",
    "question": "What is associated with Abnormal sweat electrolytes?",
    "seeds": [
      "Abnormal sweat electrolytes"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04135",
    "question": "What is associated with Pancreatic alpha-cell hyperplasia?",
    "seeds": [
      "Pancreatic alpha-cell hyperplasia"
    ],
    "gold_answer": "Pancreatic islet-cell hyperplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04136",
    "question": "What is associated with Spastic paraplegia-severe developmental delay-epilepsy syndrome?",
    "seeds": [
      "Spastic paraplegia-severe developmental delay-epilepsy syndrome"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04137",
    "question": "What is associated with Blepharospasm?",
    "seeds": [
      "Blepharospasm"
    ],
    "gold_answer": "Dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04138",
    "question": "What is associated with Spastic/hyperactive bladder?",
    "seeds": [
      "Spastic/hyperactive bladder"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04139",
    "question": "What is associated with Frontal venous angioma?",
    "seeds": [
      "Frontal venous angioma"
    ],
    "gold_answer": "Cerebral venous angioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04140",
    "question": "What is associated with Positive bloodstream influenza nucleic test?",
    "seeds": [
      "Positive bloodstream influenza nucleic test"
    ],
    "gold_answer": "Positive bloodstream nucleic acid pathogen test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04141",
    "question": "What phenotype is associated with 48,XXXY syndrome?",
    "seeds": [
      "48,XXXY syndrome"
    ],
    "gold_answer": "Clinodactyly of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04142",
    "question": "What phenotype is associated with Diamond-Blackfan anemia 20?",
    "seeds": [
      "Diamond-Blackfan anemia 20"
    ],
    "gold_answer": "Total anomalous pulmonary venous return",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04143",
    "question": "What is associated with Spastic paraplegia 18A, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 18A, autosomal dominant"
    ],
    "gold_answer": "Abnormality of the ankle",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04144",
    "question": "What is associated with Hypogonadotropic hypogonadism 15 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 15 with or without anosmia"
    ],
    "gold_answer": "Abnormal knee morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04145",
    "question": "What is associated with Lymph-node hemophagocytosis?",
    "seeds": [
      "Lymph-node hemophagocytosis"
    ],
    "gold_answer": "Hemophagocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04146",
    "question": "What is associated with Reduced alpha/beta synthesis ratio?",
    "seeds": [
      "Reduced alpha/beta synthesis ratio"
    ],
    "gold_answer": "Imbalanced hemoglobin synthesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04147",
    "question": "What is associated with Cowchock syndrome?",
    "seeds": [
      "Cowchock syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04148",
    "question": "What phenotype is associated with Thumb deformity and alopecia?",
    "seeds": [
      "Thumb deformity and alopecia"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04149",
    "question": "What is associated with Breast myxoma?",
    "seeds": [
      "Breast myxoma"
    ],
    "gold_answer": "Neoplasm of the breast",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04150",
    "question": "What phenotype is associated with Atelosteogenesis, type II?",
    "seeds": [
      "Atelosteogenesis, type II"
    ],
    "gold_answer": "Dumbbell-shaped femur",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04151",
    "question": "What is associated with Positive CSF enterovirus nucleic acid test?",
    "seeds": [
      "Positive CSF enterovirus nucleic acid test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04152",
    "question": "What is associated with Periodontitis, aggressive, 1?",
    "seeds": [
      "Periodontitis, aggressive, 1"
    ],
    "gold_answer": "Abnormal skin morphology of the palm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04153",
    "question": "What is associated with Advanced eruption of teeth?",
    "seeds": [
      "Advanced eruption of teeth"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04154",
    "question": "What is associated with Addictive spending behavior?",
    "seeds": [
      "Addictive spending behavior"
    ],
    "gold_answer": "Addictive non-substance behaviors",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04155",
    "question": "What phenotype is associated with HNF1B-related autosomal dominant tubulointerstitial kidney disease?",
    "seeds": [
      "HNF1B-related autosomal dominant tubulointerstitial kidney disease"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04156",
    "question": "What is associated with Abnormality of mucopolysaccharide metabolism?",
    "seeds": [
      "Abnormality of mucopolysaccharide metabolism"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04157",
    "question": "What is associated with Scalp defects-postaxial polydactyly syndrome?",
    "seeds": [
      "Scalp defects-postaxial polydactyly syndrome"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04158",
    "question": "What is associated with Rubber-like lump?",
    "seeds": [
      "Rubber-like lump"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04159",
    "question": "What is associated with Calcaneonavicular fusion?",
    "seeds": [
      "Calcaneonavicular fusion"
    ],
    "gold_answer": "Synostosis involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04160",
    "question": "What is associated with Supernumerary bones of the axial skeleton?",
    "seeds": [
      "Supernumerary bones of the axial skeleton"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04161",
    "question": "What phenotype is associated with Extraoral halitosis due to MTO deficiency?",
    "seeds": [
      "Extraoral halitosis due to MTO deficiency"
    ],
    "gold_answer": "Halitosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04162",
    "question": "What is associated with Primary biliary cholangitis?",
    "seeds": [
      "Primary biliary cholangitis"
    ],
    "gold_answer": "Unusual fungal infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04163",
    "question": "What is associated with History of abdominal surgery?",
    "seeds": [
      "History of abdominal surgery"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04164",
    "question": "What phenotype is associated with Deafness, neurosensory, autosomal recessive 2?",
    "seeds": [
      "Deafness, neurosensory, autosomal recessive 2"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04165",
    "question": "What is associated with Acute zonal occult outer retinopathy?",
    "seeds": [
      "Acute zonal occult outer retinopathy"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04166",
    "question": "What is associated with Epigastric pain?",
    "seeds": [
      "Epigastric pain"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04167",
    "question": "What is associated with Abnormality of urine homeostasis?",
    "seeds": [
      "Abnormality of urine homeostasis"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04168",
    "question": "What is associated with Glycogen storage disease type IXb?",
    "seeds": [
      "Glycogen storage disease type IXb"
    ],
    "gold_answer": "Abnormal muscle tissue metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04169",
    "question": "What is associated with Hypoplastic optic chiasm?",
    "seeds": [
      "Hypoplastic optic chiasm"
    ],
    "gold_answer": "Abnormal optic chiasm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04170",
    "question": "What is associated with Pinhole visual acuity 1.3 LogMAR?",
    "seeds": [
      "Pinhole visual acuity 1.3 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04171",
    "question": "What is associated with Sheldon-Hall syndrome?",
    "seeds": [
      "Sheldon-Hall syndrome"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04172",
    "question": "What is associated with Eosinophilic infiltration of the esophagus?",
    "seeds": [
      "Eosinophilic infiltration of the esophagus"
    ],
    "gold_answer": "Gastrointestinal inflammation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04173",
    "question": "What is associated with Anti-voltage-gated potassium channel antibody positivity?",
    "seeds": [
      "Anti-voltage-gated potassium channel antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04174",
    "question": "What is associated with Mandibulofacial dysostosis?",
    "seeds": [
      "Mandibulofacial dysostosis"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04175",
    "question": "What is associated with Hypoplasia of eyelid?",
    "seeds": [
      "Hypoplasia of eyelid"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04176",
    "question": "What is associated with Focal aware autonomic seizure with palpitations/tachycardia/bradycardia/asystole?",
    "seeds": [
      "Focal aware autonomic seizure with palpitations/tachycardia/bradycardia/asystole"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04177",
    "question": "What is associated with Immune dysregulation?",
    "seeds": [
      "Immune dysregulation"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04178",
    "question": "What phenotype is associated with Hyperphenylalaninemia, BH4-deficient, A?",
    "seeds": [
      "Hyperphenylalaninemia, BH4-deficient, A"
    ],
    "gold_answer": "Progressive neurologic deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04179",
    "question": "What is associated with Teeth, odd shapes oflobodontia, included?",
    "seeds": [
      "Teeth, odd shapes oflobodontia, included"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04180",
    "question": "What is associated with Abnormal Langerhans cell morphology?",
    "seeds": [
      "Abnormal Langerhans cell morphology"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04181",
    "question": "What is associated with Abnormality of thumb epiphysis?",
    "seeds": [
      "Abnormality of thumb epiphysis"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04182",
    "question": "What is associated with Onychoheterotopia?",
    "seeds": [
      "Onychoheterotopia"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04183",
    "question": "What is associated with Absent hallux epiphysis?",
    "seeds": [
      "Absent hallux epiphysis"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04184",
    "question": "What is associated with Abnormal uvula morphology?",
    "seeds": [
      "Abnormal uvula morphology"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04185",
    "question": "What is associated with Radiodense?",
    "seeds": [
      "Radiodense"
    ],
    "gold_answer": "Radiographic modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04186",
    "question": "What is associated with Right ventricular cardiomyopathy?",
    "seeds": [
      "Right ventricular cardiomyopathy"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04187",
    "question": "What is associated with SURF1-related Charcot-Marie-Tooth disease type 4?",
    "seeds": [
      "SURF1-related Charcot-Marie-Tooth disease type 4"
    ],
    "gold_answer": "SURF1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04188",
    "question": "What is associated with Chronic active Epstein-Barr virus infection?",
    "seeds": [
      "Chronic active Epstein-Barr virus infection"
    ],
    "gold_answer": "Chronic infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04189",
    "question": "What is associated with Paroxysmal ventricular tachycardia?",
    "seeds": [
      "Paroxysmal ventricular tachycardia"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04190",
    "question": "What phenotype is associated with EEM syndrome?",
    "seeds": [
      "EEM syndrome"
    ],
    "gold_answer": "Widely spaced teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04191",
    "question": "What is associated with Hydrocephalus-obesity-hypogonadism syndrome?",
    "seeds": [
      "Hydrocephalus-obesity-hypogonadism syndrome"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04192",
    "question": "What phenotype is associated with Mitochondrial complex IV deficiency, nuclear type 7?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 7"
    ],
    "gold_answer": "Myalgia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04193",
    "question": "What is associated with Increased caudate lactate level?",
    "seeds": [
      "Increased caudate lactate level"
    ],
    "gold_answer": "Abnormal basal ganglia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04194",
    "question": "What is associated with Accessory scaphoid?",
    "seeds": [
      "Accessory scaphoid"
    ],
    "gold_answer": "Abnormal wrist morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04195",
    "question": "What is associated with Congenital disorder of glycosylation, type IIw?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIw"
    ],
    "gold_answer": "Hernia of the abdominal wall",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04196",
    "question": "What is associated with Thoracoabdominal wall defect?",
    "seeds": [
      "Thoracoabdominal wall defect"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04197",
    "question": "What is associated with Oligoclonal elevated circulating IgE concentration?",
    "seeds": [
      "Oligoclonal elevated circulating IgE concentration"
    ],
    "gold_answer": "Increased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04198",
    "question": "What is associated with Sclerosis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Sclerosis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04199",
    "question": "What is associated with Tessier number 30 facial cleft?",
    "seeds": [
      "Tessier number 30 facial cleft"
    ],
    "gold_answer": "Tessier cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04200",
    "question": "What is associated with Anti-laminin antibody positivity?",
    "seeds": [
      "Anti-laminin antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04201",
    "question": "What phenotype is associated with Spastic paraplegia-Paget disease of bone syndrome?",
    "seeds": [
      "Spastic paraplegia-Paget disease of bone syndrome"
    ],
    "gold_answer": "Tongue fasciculations",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04202",
    "question": "What is associated with T-cell acute lymphoblastic leukemias?",
    "seeds": [
      "T-cell acute lymphoblastic leukemias"
    ],
    "gold_answer": "Acute lymphoblastic leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04203",
    "question": "What is associated with Renal tubular dysfunction?",
    "seeds": [
      "Renal tubular dysfunction"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04204",
    "question": "What is associated with Abnormal mandible morphology?",
    "seeds": [
      "Abnormal mandible morphology"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04205",
    "question": "What is associated with Abnormal coronary artery course?",
    "seeds": [
      "Abnormal coronary artery course"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04206",
    "question": "What is associated with Tibial deviation of the 2nd toe?",
    "seeds": [
      "Tibial deviation of the 2nd toe"
    ],
    "gold_answer": "Deviation of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04207",
    "question": "What is associated with Pseudohypoaldosteronism, type IIE?",
    "seeds": [
      "Pseudohypoaldosteronism, type IIE"
    ],
    "gold_answer": "Increased blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04208",
    "question": "What phenotype is associated with Early-onset autosomal dominant Alzheimer disease?",
    "seeds": [
      "Early-onset autosomal dominant Alzheimer disease"
    ],
    "gold_answer": "Disinhibition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04209",
    "question": "What is associated with Thoracic hypoplasia?",
    "seeds": [
      "Thoracic hypoplasia"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04210",
    "question": "What is associated with History of adrenalectomy?",
    "seeds": [
      "History of adrenalectomy"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04211",
    "question": "What is associated with Dopamine antagonist exposure?",
    "seeds": [
      "Dopamine antagonist exposure"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04212",
    "question": "What is associated with Short pointed phalanges?",
    "seeds": [
      "Short pointed phalanges"
    ],
    "gold_answer": "Short phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04213",
    "question": "What phenotype is associated with Pyoderma gangrenosum?",
    "seeds": [
      "Pyoderma gangrenosum"
    ],
    "gold_answer": "Rheumatoid factor positive",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04214",
    "question": "What is associated with Loeys-Dietz syndrome 2?",
    "seeds": [
      "Loeys-Dietz syndrome 2"
    ],
    "gold_answer": "Abnormal midface morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04215",
    "question": "What phenotype is associated with Drug reaction with eosinophilia and systemic symptoms?",
    "seeds": [
      "Drug reaction with eosinophilia and systemic symptoms"
    ],
    "gold_answer": "Erythroderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04216",
    "question": "What is associated with Abnormality of the vestibular window?",
    "seeds": [
      "Abnormality of the vestibular window"
    ],
    "gold_answer": "Abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04217",
    "question": "What is associated with Bronchoconstriction?",
    "seeds": [
      "Bronchoconstriction"
    ],
    "gold_answer": "Abnormal bronchus physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04218",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2HH?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2HH"
    ],
    "gold_answer": "Hypoesthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04219",
    "question": "What is associated with Focal aware cognitive seizure with dysgraphia/agraphia?",
    "seeds": [
      "Focal aware cognitive seizure with dysgraphia/agraphia"
    ],
    "gold_answer": "Focal aware non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04220",
    "question": "What is associated with Fractured ankle?",
    "seeds": [
      "Fractured ankle"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04221",
    "question": "What phenotype is associated with Pyruvate dehydrogenase E1-beta deficiency?",
    "seeds": [
      "Pyruvate dehydrogenase E1-beta deficiency"
    ],
    "gold_answer": "Impaired smooth pursuit",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04222",
    "question": "What is associated with Streak ovary?",
    "seeds": [
      "Streak ovary"
    ],
    "gold_answer": "Abnormal ovarian morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04223",
    "question": "What is associated with Elevated circulating medium-chain acylcarnitine concentration?",
    "seeds": [
      "Elevated circulating medium-chain acylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating fatty-acid anion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04224",
    "question": "What is associated with Focal-onset epileptic spasm?",
    "seeds": [
      "Focal-onset epileptic spasm"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04225",
    "question": "What phenotype is associated with Peroxisome biogenesis disorder 3B?",
    "seeds": [
      "Peroxisome biogenesis disorder 3B"
    ],
    "gold_answer": "Osteoporosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04226",
    "question": "What is associated with Hemolytic anemia with thermal sensitivity of red cells?",
    "seeds": [
      "Hemolytic anemia with thermal sensitivity of red cells"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04227",
    "question": "What is associated with Handgrip myotonia?",
    "seeds": [
      "Handgrip myotonia"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04228",
    "question": "What is associated with Broad diaphyses of the upper limbs?",
    "seeds": [
      "Broad diaphyses of the upper limbs"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04229",
    "question": "What is associated with Hyperaldosteronism, familial, type III?",
    "seeds": [
      "Hyperaldosteronism, familial, type III"
    ],
    "gold_answer": "Abnormal circulating renin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04230",
    "question": "What is associated with Infantile liver failure syndrome 1?",
    "seeds": [
      "Infantile liver failure syndrome 1"
    ],
    "gold_answer": "Abnormal shape of the frontal region",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04231",
    "question": "What is associated with Abnormal retinal morphology?",
    "seeds": [
      "Abnormal retinal morphology"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04232",
    "question": "What is associated with Iron overload in africa?",
    "seeds": [
      "Iron overload in africa"
    ],
    "gold_answer": "Abnormality of iron homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04233",
    "question": "What is associated with Toenail dysplasia?",
    "seeds": [
      "Toenail dysplasia"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04234",
    "question": "What is associated with Reduced tissue acetyl-CoA carboxylase activity?",
    "seeds": [
      "Reduced tissue acetyl-CoA carboxylase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04235",
    "question": "What is associated with Statin exposure?",
    "seeds": [
      "Statin exposure"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04236",
    "question": "What is associated with Lymph node necrosis?",
    "seeds": [
      "Lymph node necrosis"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04237",
    "question": "What is associated with Fragmented elastic fibers in the dermis?",
    "seeds": [
      "Fragmented elastic fibers in the dermis"
    ],
    "gold_answer": "Abnormal cutaneous elastic fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04238",
    "question": "What is associated with Progressive loss of facial adipose tissue?",
    "seeds": [
      "Progressive loss of facial adipose tissue"
    ],
    "gold_answer": "Loss of facial adipose tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04239",
    "question": "What is associated with Gonadal neoplasm?",
    "seeds": [
      "Gonadal neoplasm"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04240",
    "question": "What is associated with Multiple epiphyseal dysplasia type 4?",
    "seeds": [
      "Multiple epiphyseal dysplasia type 4"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04241",
    "question": "What is associated with Long phalanx of finger?",
    "seeds": [
      "Long phalanx of finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04242",
    "question": "What is associated with Bile acid malabsorption, primary?",
    "seeds": [
      "Bile acid malabsorption, primary"
    ],
    "gold_answer": "Abnormal digestive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04243",
    "question": "What is associated with Superficial thrombophlebitis?",
    "seeds": [
      "Superficial thrombophlebitis"
    ],
    "gold_answer": "Thrombophlebitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04244",
    "question": "What is associated with Aneurysmal bone cyst?",
    "seeds": [
      "Aneurysmal bone cyst"
    ],
    "gold_answer": "Bone cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04245",
    "question": "What is associated with Hyperapobetalipoproteinemia?",
    "seeds": [
      "Hyperapobetalipoproteinemia"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04246",
    "question": "What is associated with Yellow subcutaneous tissue covered by thin, scaly skin?",
    "seeds": [
      "Yellow subcutaneous tissue covered by thin, scaly skin"
    ],
    "gold_answer": "Abnormality of subcutaneous fat tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04247",
    "question": "What is associated with Abnormal monocyte morphology?",
    "seeds": [
      "Abnormal monocyte morphology"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04248",
    "question": "What is associated with Hypotrichosis 14?",
    "seeds": [
      "Hypotrichosis 14"
    ],
    "gold_answer": "Abnormality of the axillary hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04249",
    "question": "What is associated with Erythrocytosis 7?",
    "seeds": [
      "Erythrocytosis 7"
    ],
    "gold_answer": "Abnormal hemoglobin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04250",
    "question": "What is associated with CADINS disease?",
    "seeds": [
      "CADINS disease"
    ],
    "gold_answer": "CARD11",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_04251",
    "question": "What is associated with Sweeney-Cox syndrome?",
    "seeds": [
      "Sweeney-Cox syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the external ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04252",
    "question": "What is associated with Abnormal fucosylation of O-linked protein glycosylation?",
    "seeds": [
      "Abnormal fucosylation of O-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04253",
    "question": "What is associated with Basilar artery calcification?",
    "seeds": [
      "Basilar artery calcification"
    ],
    "gold_answer": "Intracranial arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04254",
    "question": "What is associated with Spinocerebellar ataxia 26?",
    "seeds": [
      "Spinocerebellar ataxia 26"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04255",
    "question": "What is associated with Progressive myoclonic epilepsy type 1?",
    "seeds": [
      "Progressive myoclonic epilepsy type 1"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04256",
    "question": "What is associated with Albinism, ocular, with late-onset sensorineural deafness?",
    "seeds": [
      "Albinism, ocular, with late-onset sensorineural deafness"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04257",
    "question": "What is associated with Multiple glomerular cysts?",
    "seeds": [
      "Multiple glomerular cysts"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04258",
    "question": "What is associated with Myopathy, reducing body, X-linked, childhood-onset?",
    "seeds": [
      "Myopathy, reducing body, X-linked, childhood-onset"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04259",
    "question": "What is associated with Multiple meningiomas?",
    "seeds": [
      "Multiple meningiomas"
    ],
    "gold_answer": "Heteronymous hemianopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04260",
    "question": "What is associated with Spina bifida occulta at S1?",
    "seeds": [
      "Spina bifida occulta at S1"
    ],
    "gold_answer": "Spinal dysraphism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04261",
    "question": "What is associated with Ivory epiphyses of the toes?",
    "seeds": [
      "Ivory epiphyses of the toes"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04262",
    "question": "What is associated with Ataxia with myoclonic epilepsy and presenile dementia?",
    "seeds": [
      "Ataxia with myoclonic epilepsy and presenile dementia"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04263",
    "question": "What is associated with Glomerular hyaline pseudothrombus?",
    "seeds": [
      "Glomerular hyaline pseudothrombus"
    ],
    "gold_answer": "Abnormal glomerular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04264",
    "question": "What is associated with Macroorchidism, postpubertal?",
    "seeds": [
      "Macroorchidism, postpubertal"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04265",
    "question": "What phenotype is associated with Exudative vitreoretinopathy 6?",
    "seeds": [
      "Exudative vitreoretinopathy 6"
    ],
    "gold_answer": "Esodeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04266",
    "question": "What is associated with Recurrent plantar mycosis?",
    "seeds": [
      "Recurrent plantar mycosis"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04267",
    "question": "What phenotype is associated with Paroxysmal cold hemoglobinuria?",
    "seeds": [
      "Paroxysmal cold hemoglobinuria"
    ],
    "gold_answer": "Headache",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04268",
    "question": "What is associated with Short-limb skeletal dysplasia with severe combined immunodeficiency?",
    "seeds": [
      "Short-limb skeletal dysplasia with severe combined immunodeficiency"
    ],
    "gold_answer": "Immunodeficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04269",
    "question": "What is associated with Shoulder abduction contracture?",
    "seeds": [
      "Shoulder abduction contracture"
    ],
    "gold_answer": "Abnormal shoulder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04270",
    "question": "What is associated with Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1?",
    "seeds": [
      "Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04271",
    "question": "What phenotype is associated with Nystagmus 2, congenital, autosomal dominant?",
    "seeds": [
      "Nystagmus 2, congenital, autosomal dominant"
    ],
    "gold_answer": "Mildly reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04272",
    "question": "What is associated with Irregularly shaped lymph node germinal centers?",
    "seeds": [
      "Irregularly shaped lymph node germinal centers"
    ],
    "gold_answer": "Abnormal lymph-node tissue architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04273",
    "question": "What is associated with Pseudoepiphyses of the middle phalanges of the hand?",
    "seeds": [
      "Pseudoepiphyses of the middle phalanges of the hand"
    ],
    "gold_answer": "Pseudoepiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04274",
    "question": "What is associated with Osteolytic defects of the distal phalanx of the 5th finger?",
    "seeds": [
      "Osteolytic defects of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Osteolytic defects of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04275",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 40?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 40"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04276",
    "question": "What phenotype is associated with Renal-hepatic-pancreatic dysplasia?",
    "seeds": [
      "Renal-hepatic-pancreatic dysplasia"
    ],
    "gold_answer": "Pancreatic fibrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04277",
    "question": "What is associated with Aphakia?",
    "seeds": [
      "Aphakia"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04278",
    "question": "What is associated with Osteolysis?",
    "seeds": [
      "Osteolysis"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04279",
    "question": "What is associated with Hypotrichosis 5?",
    "seeds": [
      "Hypotrichosis 5"
    ],
    "gold_answer": "Abnormal eyelash morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04280",
    "question": "What phenotype is associated with Coffin-Siris syndrome 11?",
    "seeds": [
      "Coffin-Siris syndrome 11"
    ],
    "gold_answer": "Gastroesophageal reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04281",
    "question": "What is associated with Polycystic kidney disease 6 with or without polycystic liver disease?",
    "seeds": [
      "Polycystic kidney disease 6 with or without polycystic liver disease"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04282",
    "question": "What is associated with Hyperplasia of the femoral trochanters?",
    "seeds": [
      "Hyperplasia of the femoral trochanters"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04283",
    "question": "What phenotype is associated with Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young?",
    "seeds": [
      "Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04284",
    "question": "What is associated with Ovarioleukodystrophy?",
    "seeds": [
      "Ovarioleukodystrophy"
    ],
    "gold_answer": "EIF2B2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04285",
    "question": "What is associated with Hyperphalangy of the 4th finger?",
    "seeds": [
      "Hyperphalangy of the 4th finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04286",
    "question": "What is associated with Tubular basement membrane disintegration?",
    "seeds": [
      "Tubular basement membrane disintegration"
    ],
    "gold_answer": "Abnormal tubular basement membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04287",
    "question": "What is associated with Anemia, sideroblastic, X-linked?",
    "seeds": [
      "Anemia, sideroblastic, X-linked"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04288",
    "question": "What is associated with Elevated urine malic acid level?",
    "seeds": [
      "Elevated urine malic acid level"
    ],
    "gold_answer": "Dicarboxylic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04289",
    "question": "What is associated with Nutrition history?",
    "seeds": [
      "Nutrition history"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04290",
    "question": "What is associated with Lenticular astigmatism?",
    "seeds": [
      "Lenticular astigmatism"
    ],
    "gold_answer": "Astigmatism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04291",
    "question": "What is associated with Beta 2-microglobulinuria?",
    "seeds": [
      "Beta 2-microglobulinuria"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04292",
    "question": "What is associated with Congenital pulmonary airway malformation?",
    "seeds": [
      "Congenital pulmonary airway malformation"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04293",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 113?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 113"
    ],
    "gold_answer": "Mild intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04294",
    "question": "What is associated with Elevated CSF 14-3-3 protein concentration?",
    "seeds": [
      "Elevated CSF 14-3-3 protein concentration"
    ],
    "gold_answer": "Abnormal CSF protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04295",
    "question": "What is associated with Pain at the posterior aspect of the knee?",
    "seeds": [
      "Pain at the posterior aspect of the knee"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04296",
    "question": "What is associated with Irregular epiphysis of the 1st metatarsal?",
    "seeds": [
      "Irregular epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04297",
    "question": "What is associated with Retinitis pigmentosa 83?",
    "seeds": [
      "Retinitis pigmentosa 83"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04298",
    "question": "What is associated with Symptomatic form of Coffin-Lowry syndrome in female carriers?",
    "seeds": [
      "Symptomatic form of Coffin-Lowry syndrome in female carriers"
    ],
    "gold_answer": "Conical incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04299",
    "question": "What phenotype is associated with Achromatopsia 7?",
    "seeds": [
      "Achromatopsia 7"
    ],
    "gold_answer": "Hypoplasia of the fovea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04300",
    "question": "What is associated with Gallbladder disease 1?",
    "seeds": [
      "Gallbladder disease 1"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04301",
    "question": "What is associated with Episodic abdominal pain?",
    "seeds": [
      "Episodic abdominal pain"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04302",
    "question": "What is associated with Hypsarrhythmia?",
    "seeds": [
      "Hypsarrhythmia"
    ],
    "gold_answer": "Interictal EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04303",
    "question": "What is associated with Late-onset spinocerebellar degeneration?",
    "seeds": [
      "Late-onset spinocerebellar degeneration"
    ],
    "gold_answer": "Spinocerebellar tract degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04304",
    "question": "What is associated with Elevated CSF hydroxyproline concentration?",
    "seeds": [
      "Elevated CSF hydroxyproline concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04305",
    "question": "What is associated with Meat allergen allergy?",
    "seeds": [
      "Meat allergen allergy"
    ],
    "gold_answer": "Allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04306",
    "question": "What is associated with Paroxysmal choreoathetosis?",
    "seeds": [
      "Paroxysmal choreoathetosis"
    ],
    "gold_answer": "Choreoathetosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04307",
    "question": "What is associated with Reduced lymphocyte surface expression of CD43?",
    "seeds": [
      "Reduced lymphocyte surface expression of CD43"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04308",
    "question": "What is associated with Intercrural pterygium?",
    "seeds": [
      "Intercrural pterygium"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04309",
    "question": "What is associated with Delayed speech and language development?",
    "seeds": [
      "Delayed speech and language development"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04310",
    "question": "What is associated with Abnormality of the falx cerebri?",
    "seeds": [
      "Abnormality of the falx cerebri"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04311",
    "question": "What is associated with Leprosy?",
    "seeds": [
      "Leprosy"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04312",
    "question": "What is associated with Premature closure of fontanelles?",
    "seeds": [
      "Premature closure of fontanelles"
    ],
    "gold_answer": "Abnormal cranial suture/fontanelle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04313",
    "question": "What is associated with Diet-resistant subcutaneous adipose tissue below waist?",
    "seeds": [
      "Diet-resistant subcutaneous adipose tissue below waist"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04314",
    "question": "What is associated with Abnormal greater palatine artery morphology?",
    "seeds": [
      "Abnormal greater palatine artery morphology"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04315",
    "question": "What is associated with Sarcosinemia?",
    "seeds": [
      "Sarcosinemia"
    ],
    "gold_answer": "Distal lower limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04316",
    "question": "What is associated with Decreased iduronate sulfatase level?",
    "seeds": [
      "Decreased iduronate sulfatase level"
    ],
    "gold_answer": "Abnormal iduronate sulfatase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04317",
    "question": "What phenotype is associated with Triploidy syndrome?",
    "seeds": [
      "Triploidy syndrome"
    ],
    "gold_answer": "Tetralogy of Fallot",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04318",
    "question": "What is associated with Elevated CSF dihydrothymine concentration?",
    "seeds": [
      "Elevated CSF dihydrothymine concentration"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04319",
    "question": "What is associated with Hyperkalemic metabolic acidosis?",
    "seeds": [
      "Hyperkalemic metabolic acidosis"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04320",
    "question": "What is associated with Retinal hole?",
    "seeds": [
      "Retinal hole"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04321",
    "question": "What is associated with Limited hip extension?",
    "seeds": [
      "Limited hip extension"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04322",
    "question": "What phenotype is associated with 48,XYYY syndrome?",
    "seeds": [
      "48,XYYY syndrome"
    ],
    "gold_answer": "Thick lower lip vermilion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04323",
    "question": "What phenotype is associated with Lynch syndrome I?",
    "seeds": [
      "Lynch syndrome I"
    ],
    "gold_answer": "Colon cancer",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04324",
    "question": "What is associated with Right ventricular regional wall motion abnormality?",
    "seeds": [
      "Right ventricular regional wall motion abnormality"
    ],
    "gold_answer": "Abnormal right ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04325",
    "question": "What is associated with Aplasia of the maxilla?",
    "seeds": [
      "Aplasia of the maxilla"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04326",
    "question": "What is associated with Posterior staphyloma?",
    "seeds": [
      "Posterior staphyloma"
    ],
    "gold_answer": "Abnormal sclera morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04327",
    "question": "What is associated with Cutaneous syndactyly of toes?",
    "seeds": [
      "Cutaneous syndactyly of toes"
    ],
    "gold_answer": "Syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04328",
    "question": "What is associated with Peho-Like syndrome?",
    "seeds": [
      "Peho-Like syndrome"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04329",
    "question": "What is associated with IgG4-related aortitis?",
    "seeds": [
      "IgG4-related aortitis"
    ],
    "gold_answer": "Increased circulating IgG subclass",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04330",
    "question": "What is associated with Paranoia?",
    "seeds": [
      "Paranoia"
    ],
    "gold_answer": "Disorder of thought content",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04331",
    "question": "What is associated with Glomerular pseudocrescent?",
    "seeds": [
      "Glomerular pseudocrescent"
    ],
    "gold_answer": "Abnormal Bowman capsule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04332",
    "question": "What is associated with Abnormal sputum?",
    "seeds": [
      "Abnormal sputum"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04333",
    "question": "What is associated with Central cyanosis?",
    "seeds": [
      "Central cyanosis"
    ],
    "gold_answer": "Dermatological manifestations of systemic disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04334",
    "question": "What is associated with Cervical vertebral dysplasia?",
    "seeds": [
      "Cervical vertebral dysplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04335",
    "question": "What phenotype is associated with Metaphyseal chondrodysplasia, Spahr type?",
    "seeds": [
      "Metaphyseal chondrodysplasia, Spahr type"
    ],
    "gold_answer": "Genu valgum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04336",
    "question": "What is associated with Sparse lower eyelashes?",
    "seeds": [
      "Sparse lower eyelashes"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04337",
    "question": "What is associated with Increased T cell apoptosis?",
    "seeds": [
      "Increased T cell apoptosis"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04338",
    "question": "What is associated with Rare X-linked non-syndromic sensorineural deafness type DFN?",
    "seeds": [
      "Rare X-linked non-syndromic sensorineural deafness type DFN"
    ],
    "gold_answer": "SMPX",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04339",
    "question": "What is associated with Reduced lymphocyte surface expression of CD43?",
    "seeds": [
      "Reduced lymphocyte surface expression of CD43"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04340",
    "question": "What is associated with Stippling of the epiphysis of the distal phalanx of the 2nd finger?",
    "seeds": [
      "Stippling of the epiphysis of the distal phalanx of the 2nd finger"
    ],
    "gold_answer": "Stippling of the epiphyses of the distal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04341",
    "question": "What is associated with Abnormal CSF leucine concentration?",
    "seeds": [
      "Abnormal CSF leucine concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04342",
    "question": "What is associated with Decreased circulating aspartic acid concentration?",
    "seeds": [
      "Decreased circulating aspartic acid concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04343",
    "question": "What is associated with Extracranial carotid artery aneurysm?",
    "seeds": [
      "Extracranial carotid artery aneurysm"
    ],
    "gold_answer": "Abnormal arterial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04344",
    "question": "What is associated with Squamous metaplasia?",
    "seeds": [
      "Squamous metaplasia"
    ],
    "gold_answer": "Histopathological abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04345",
    "question": "What is associated with Capillary-lymphatic-venous malformation with segmental distribution?",
    "seeds": [
      "Capillary-lymphatic-venous malformation with segmental distribution"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04346",
    "question": "What is associated with Dysplastic sacrum?",
    "seeds": [
      "Dysplastic sacrum"
    ],
    "gold_answer": "Abnormal sacrum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04347",
    "question": "What is associated with Partial duplication of the phalanx of hand?",
    "seeds": [
      "Partial duplication of the phalanx of hand"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04348",
    "question": "What is associated with Deafness, sensorineural, and male infertility?",
    "seeds": [
      "Deafness, sensorineural, and male infertility"
    ],
    "gold_answer": "Abnormal male reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04349",
    "question": "What is associated with Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease?",
    "seeds": [
      "Hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease"
    ],
    "gold_answer": "TNNI3K",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04350",
    "question": "What is associated with Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome?",
    "seeds": [
      "Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04351",
    "question": "What is associated with Increased red blood cell count?",
    "seeds": [
      "Increased red blood cell count"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04352",
    "question": "What is associated with Spermatogenic failure 37?",
    "seeds": [
      "Spermatogenic failure 37"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04353",
    "question": "What phenotype is associated with Autosomal dominant progressive external ophthalmoplegia?",
    "seeds": [
      "Autosomal dominant progressive external ophthalmoplegia"
    ],
    "gold_answer": "Dysphagia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04354",
    "question": "What phenotype is associated with Microphthalmia, syndromic 5?",
    "seeds": [
      "Microphthalmia, syndromic 5"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04355",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 31?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 31"
    ],
    "gold_answer": "Supraventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04356",
    "question": "What is associated with Familial hyperthyroidism due to mutations in TSH receptor?",
    "seeds": [
      "Familial hyperthyroidism due to mutations in TSH receptor"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04357",
    "question": "What is associated with Vertical nystagmus?",
    "seeds": [
      "Vertical nystagmus"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04358",
    "question": "What is associated with Ocular cystinosis?",
    "seeds": [
      "Ocular cystinosis"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04359",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Sclerosis of 4th toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04360",
    "question": "What phenotype is associated with Bazex syndrome?",
    "seeds": [
      "Bazex syndrome"
    ],
    "gold_answer": "Palmoplantar keratoderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04361",
    "question": "What is associated with Abnormal greater sciatic notch morphology?",
    "seeds": [
      "Abnormal greater sciatic notch morphology"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04362",
    "question": "What is associated with Platelet-Activating factor acetylhydrolase deficiency?",
    "seeds": [
      "Platelet-Activating factor acetylhydrolase deficiency"
    ],
    "gold_answer": "Abnormal level of platelet-activating factor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04363",
    "question": "What is associated with 6 metacarpals?",
    "seeds": [
      "6 metacarpals"
    ],
    "gold_answer": "Supernumerary metacarpal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04364",
    "question": "What is associated with Spondylometaepiphyseal dysplasia, short Limb-Hand type?",
    "seeds": [
      "Spondylometaepiphyseal dysplasia, short Limb-Hand type"
    ],
    "gold_answer": "Abnormal fontanelle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04365",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 53?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 53"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04366",
    "question": "What is associated with Neonatal bilateral asymmetric myoclonic seizure?",
    "seeds": [
      "Neonatal bilateral asymmetric myoclonic seizure"
    ],
    "gold_answer": "Neonatal electro-clinical motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04367",
    "question": "What is associated with Abnormal mean corpuscular hemoglobin concentration?",
    "seeds": [
      "Abnormal mean corpuscular hemoglobin concentration"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04368",
    "question": "What phenotype is associated with Joubert syndrome 30?",
    "seeds": [
      "Joubert syndrome 30"
    ],
    "gold_answer": "Superior cerebellar dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04369",
    "question": "What is associated with Spur at inferior pole of patella?",
    "seeds": [
      "Spur at inferior pole of patella"
    ],
    "gold_answer": "Abnormality of the knee",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04370",
    "question": "What is associated with Perihepatic enhancement?",
    "seeds": [
      "Perihepatic enhancement"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04371",
    "question": "What is associated with Abnormal length of corpus callosum?",
    "seeds": [
      "Abnormal length of corpus callosum"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04372",
    "question": "What is associated with Excessive sleep?",
    "seeds": [
      "Excessive sleep"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04373",
    "question": "What is associated with Abnormal effector memory CD8+ T cell proportion?",
    "seeds": [
      "Abnormal effector memory CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04374",
    "question": "What is associated with Multinucleated giant chondrocytes in epiphyseal cartilage?",
    "seeds": [
      "Multinucleated giant chondrocytes in epiphyseal cartilage"
    ],
    "gold_answer": "Abnormal chondrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04375",
    "question": "What is associated with Pelvis-Shoulder dysplasia?",
    "seeds": [
      "Pelvis-Shoulder dysplasia"
    ],
    "gold_answer": "Deviation of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04376",
    "question": "What is associated with Triangular shaped phalanges of the 5th finger?",
    "seeds": [
      "Triangular shaped phalanges of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04377",
    "question": "What is associated with Recurrent meningitis?",
    "seeds": [
      "Recurrent meningitis"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04378",
    "question": "What is associated with Morning glory anomaly?",
    "seeds": [
      "Morning glory anomaly"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04379",
    "question": "What is associated with Dystonia 2, torsion, autosomal recessive?",
    "seeds": [
      "Dystonia 2, torsion, autosomal recessive"
    ],
    "gold_answer": "Craniofacial dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04380",
    "question": "What is associated with Epilepsy, progressive myoclonic, 6?",
    "seeds": [
      "Epilepsy, progressive myoclonic, 6"
    ],
    "gold_answer": "Abnormal circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04381",
    "question": "What is associated with Vaguely nodular lymph-node architecture?",
    "seeds": [
      "Vaguely nodular lymph-node architecture"
    ],
    "gold_answer": "Abnormal lymph-node tissue architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04382",
    "question": "What is associated with Reduced hepatic beta-ureidopropionase activity?",
    "seeds": [
      "Reduced hepatic beta-ureidopropionase activity"
    ],
    "gold_answer": "Abnormal liver enzyme activity or concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04383",
    "question": "What is associated with Abnormal circulating corticosterone level?",
    "seeds": [
      "Abnormal circulating corticosterone level"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04384",
    "question": "What phenotype is associated with Aicardi-Goutieres syndrome 3?",
    "seeds": [
      "Aicardi-Goutieres syndrome 3"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04385",
    "question": "What is associated with High-pitched cry?",
    "seeds": [
      "High-pitched cry"
    ],
    "gold_answer": "Abnormality of the voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04386",
    "question": "What is associated with Renal interstitial IgG4+ plasma cell infiltration?",
    "seeds": [
      "Renal interstitial IgG4+ plasma cell infiltration"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04387",
    "question": "What is associated with Intellectual developmental disorder and retinitis pigmentosa?",
    "seeds": [
      "Intellectual developmental disorder and retinitis pigmentosa"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04388",
    "question": "What is associated with Raynaud phenomenon?",
    "seeds": [
      "Raynaud phenomenon"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04389",
    "question": "What is associated with Anti-proteinase 3 antibody positivity?",
    "seeds": [
      "Anti-proteinase 3 antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04390",
    "question": "What is associated with Bullet-shaped middle phalanx of the 5th finger?",
    "seeds": [
      "Bullet-shaped middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04391",
    "question": "What is associated with Congenital megacalycosis?",
    "seeds": [
      "Congenital megacalycosis"
    ],
    "gold_answer": "Abnormal ureter physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04392",
    "question": "What is associated with Compensatory scoliosis?",
    "seeds": [
      "Compensatory scoliosis"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04393",
    "question": "What is associated with Cyst of the ductus choledochus?",
    "seeds": [
      "Cyst of the ductus choledochus"
    ],
    "gold_answer": "Abnormal ductus choledochus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04394",
    "question": "What is associated with Triggered by excitement?",
    "seeds": [
      "Triggered by excitement"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04395",
    "question": "What phenotype is associated with Mesoaxial hexadactyly and cardiac malformation?",
    "seeds": [
      "Mesoaxial hexadactyly and cardiac malformation"
    ],
    "gold_answer": "Mild intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04396",
    "question": "What is associated with Abnormal small intestinal mucosa morphology?",
    "seeds": [
      "Abnormal small intestinal mucosa morphology"
    ],
    "gold_answer": "Abnormal small intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04397",
    "question": "What is associated with Alveolar capillary dysplasia?",
    "seeds": [
      "Alveolar capillary dysplasia"
    ],
    "gold_answer": "Abnormal pulmonary alveolar system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04398",
    "question": "What is associated with Elevated urinary homovanillic acid?",
    "seeds": [
      "Elevated urinary homovanillic acid"
    ],
    "gold_answer": "Organic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04399",
    "question": "What is associated with Neutral lipid storage disease with ichthyosis?",
    "seeds": [
      "Neutral lipid storage disease with ichthyosis"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04400",
    "question": "What is associated with Pressure-induced localized lipoatrophy?",
    "seeds": [
      "Pressure-induced localized lipoatrophy"
    ],
    "gold_answer": "Abnormal adipose tissue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04401",
    "question": "What is associated with Ventricular tachycardia, familial?",
    "seeds": [
      "Ventricular tachycardia, familial"
    ],
    "gold_answer": "Bundle branch block",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04402",
    "question": "What phenotype is associated with Parkinson disease 15, autosomal recessive early-onset?",
    "seeds": [
      "Parkinson disease 15, autosomal recessive early-onset"
    ],
    "gold_answer": "Babinski sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04403",
    "question": "What is associated with Abnormal sialylation of O-linked protein glycosylation?",
    "seeds": [
      "Abnormal sialylation of O-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04404",
    "question": "What phenotype is associated with Pili torti?",
    "seeds": [
      "Pili torti"
    ],
    "gold_answer": "Abnormality of hair texture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04405",
    "question": "What is associated with Myopia 27?",
    "seeds": [
      "Myopia 27"
    ],
    "gold_answer": "Abnormality of refraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04406",
    "question": "What is associated with Postinfectious vasculitis?",
    "seeds": [
      "Postinfectious vasculitis"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04407",
    "question": "What phenotype is associated with Spinal muscular atrophy, distal, autosomal recessive, 1?",
    "seeds": [
      "Spinal muscular atrophy, distal, autosomal recessive, 1"
    ],
    "gold_answer": "Ventilator dependence with inability to wean",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04408",
    "question": "What is associated with Ciliary dyskinesia, primary, 45?",
    "seeds": [
      "Ciliary dyskinesia, primary, 45"
    ],
    "gold_answer": "Abnormal ciliary motility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04409",
    "question": "What is associated with 6-pyruvoyl-tetrahydropterin synthase deficiency?",
    "seeds": [
      "6-pyruvoyl-tetrahydropterin synthase deficiency"
    ],
    "gold_answer": "Reduced consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04410",
    "question": "What is associated with Gordon reflex?",
    "seeds": [
      "Gordon reflex"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04411",
    "question": "What is associated with Colonic diverticula?",
    "seeds": [
      "Colonic diverticula"
    ],
    "gold_answer": "Abnormal large intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04412",
    "question": "What is associated with Glycogen storage disease XV?",
    "seeds": [
      "Glycogen storage disease XV"
    ],
    "gold_answer": "Abnormality of the shoulder girdle musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04413",
    "question": "What is associated with 1-minute APGAR score of 0?",
    "seeds": [
      "1-minute APGAR score of 0"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04414",
    "question": "What phenotype is associated with Diabetes mellitus, transient neonatal, 1?",
    "seeds": [
      "Diabetes mellitus, transient neonatal, 1"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04415",
    "question": "What is associated with Hair shaft lesion?",
    "seeds": [
      "Hair shaft lesion"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04416",
    "question": "What is associated with Echogenic fetal colon?",
    "seeds": [
      "Echogenic fetal colon"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04417",
    "question": "What is associated with Triggered by excitement?",
    "seeds": [
      "Triggered by excitement"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04418",
    "question": "What is associated with COG1-CDG?",
    "seeds": [
      "COG1-CDG"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04419",
    "question": "What is associated with Olfactory hallucination?",
    "seeds": [
      "Olfactory hallucination"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04420",
    "question": "What is associated with Broad middle phalanx of the 4th finger?",
    "seeds": [
      "Broad middle phalanx of the 4th finger"
    ],
    "gold_answer": "Broad phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04421",
    "question": "What is associated with Benign paroxysmal torticollis of infancy?",
    "seeds": [
      "Benign paroxysmal torticollis of infancy"
    ],
    "gold_answer": "Headache",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04422",
    "question": "What is associated with Tryptophanuria?",
    "seeds": [
      "Tryptophanuria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04423",
    "question": "What phenotype is associated with Dysmorphism-cleft palate-loose skin syndrome?",
    "seeds": [
      "Dysmorphism-cleft palate-loose skin syndrome"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04424",
    "question": "What is associated with Fragmentation of the epiphysis of the proximal phalanx of the hallux?",
    "seeds": [
      "Fragmentation of the epiphysis of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Fragmentation of the epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04425",
    "question": "What is associated with Adrenocortical hypoplasia?",
    "seeds": [
      "Adrenocortical hypoplasia"
    ],
    "gold_answer": "Abnormality of the adrenal glands",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04426",
    "question": "What is associated with Autosomal dominant hyperinsulinism due to SUR1 deficiency?",
    "seeds": [
      "Autosomal dominant hyperinsulinism due to SUR1 deficiency"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04427",
    "question": "What is associated with Telangiectasia of extensor surfaces?",
    "seeds": [
      "Telangiectasia of extensor surfaces"
    ],
    "gold_answer": "Telangiectasia of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04428",
    "question": "What is associated with Desmoid tumor?",
    "seeds": [
      "Desmoid tumor"
    ],
    "gold_answer": "Abnormality of the urinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04429",
    "question": "What is associated with Paget disease of bone 5, juvenile-onset?",
    "seeds": [
      "Paget disease of bone 5, juvenile-onset"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04430",
    "question": "What is associated with Anti-Sm antibody positivity?",
    "seeds": [
      "Anti-Sm antibody positivity"
    ],
    "gold_answer": "Antinuclear antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04431",
    "question": "What is associated with Tachypnea?",
    "seeds": [
      "Tachypnea"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04432",
    "question": "What is associated with Kleeblattschaedel syndrome?",
    "seeds": [
      "Kleeblattschaedel syndrome"
    ],
    "gold_answer": "Corneal erosion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04433",
    "question": "What phenotype is associated with Macular dystrophy, corneal, 1?",
    "seeds": [
      "Macular dystrophy, corneal, 1"
    ],
    "gold_answer": "Photophobia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04434",
    "question": "What is associated with Abnormal CSF guanidinoacetic acid concentration?",
    "seeds": [
      "Abnormal CSF guanidinoacetic acid concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04435",
    "question": "What phenotype is associated with Ritscher-Schinzel syndrome 3?",
    "seeds": [
      "Ritscher-Schinzel syndrome 3"
    ],
    "gold_answer": "Microphthalmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04436",
    "question": "What is associated with Cloacal abnormality?",
    "seeds": [
      "Cloacal abnormality"
    ],
    "gold_answer": "Abdominal wall defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04437",
    "question": "What phenotype is associated with Anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis?",
    "seeds": [
      "Anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04438",
    "question": "What is associated with Duplication of renal pelvis?",
    "seeds": [
      "Duplication of renal pelvis"
    ],
    "gold_answer": "Renal duplication",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04439",
    "question": "What is associated with Claustrophobia?",
    "seeds": [
      "Claustrophobia"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04440",
    "question": "What is associated with Combined immunodeficiency with granulomatosis?",
    "seeds": [
      "Combined immunodeficiency with granulomatosis"
    ],
    "gold_answer": "RAG1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04441",
    "question": "What is associated with Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia?",
    "seeds": [
      "Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04442",
    "question": "What is associated with Neurofibromatosis type 1 due to NF1 mutation or intragenic deletion?",
    "seeds": [
      "Neurofibromatosis type 1 due to NF1 mutation or intragenic deletion"
    ],
    "gold_answer": "Soft tissue sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04443",
    "question": "What is associated with Carpal synostosis?",
    "seeds": [
      "Carpal synostosis"
    ],
    "gold_answer": "Synostosis involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04444",
    "question": "What is associated with Hypoplasia of the musculature?",
    "seeds": [
      "Hypoplasia of the musculature"
    ],
    "gold_answer": "Abnormality of muscle size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04445",
    "question": "What is associated with Decreased circulating aspartic acid concentration?",
    "seeds": [
      "Decreased circulating aspartic acid concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04446",
    "question": "What is associated with Childhood onset short-limb short stature?",
    "seeds": [
      "Childhood onset short-limb short stature"
    ],
    "gold_answer": "Disproportionate short-limb short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04447",
    "question": "What is associated with Altman type I sacrococcygeal teratoma?",
    "seeds": [
      "Altman type I sacrococcygeal teratoma"
    ],
    "gold_answer": "Embryonal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04448",
    "question": "What is associated with Bilateral ductus arteriosus?",
    "seeds": [
      "Bilateral ductus arteriosus"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04449",
    "question": "What is associated with Increased urinary porphobilinogen?",
    "seeds": [
      "Increased urinary porphobilinogen"
    ],
    "gold_answer": "Dicarboxylic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04450",
    "question": "What is associated with FKRP-related limb-girdle muscular dystrophy R9?",
    "seeds": [
      "FKRP-related limb-girdle muscular dystrophy R9"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04451",
    "question": "What is associated with Immune dysregulation, neurodevelopmental defects, and colitis?",
    "seeds": [
      "Immune dysregulation, neurodevelopmental defects, and colitis"
    ],
    "gold_answer": "Anal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04452",
    "question": "What phenotype is associated with Arthrogryposis, distal, type 7?",
    "seeds": [
      "Arthrogryposis, distal, type 7"
    ],
    "gold_answer": "Micrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04453",
    "question": "What is associated with Homozygous 11p15-p14 deletion syndrome?",
    "seeds": [
      "Homozygous 11p15-p14 deletion syndrome"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04454",
    "question": "What phenotype is associated with Combined oxidative phosphorylation deficiency 18?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 18"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04455",
    "question": "What is associated with Toe syndactyly?",
    "seeds": [
      "Toe syndactyly"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04456",
    "question": "What is associated with Feeding difficulties in infancy?",
    "seeds": [
      "Feeding difficulties in infancy"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04457",
    "question": "What is associated with Early-onset non-progressive night blindness?",
    "seeds": [
      "Early-onset non-progressive night blindness"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04458",
    "question": "What is associated with Type A5 brachydactyly?",
    "seeds": [
      "Type A5 brachydactyly"
    ],
    "gold_answer": "Short digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04459",
    "question": "What is associated with Pulmonary arterial medial hypertrophy?",
    "seeds": [
      "Pulmonary arterial medial hypertrophy"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04460",
    "question": "What is associated with Abnormal central response of multifocal electroretinogram?",
    "seeds": [
      "Abnormal central response of multifocal electroretinogram"
    ],
    "gold_answer": "Abnormal electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04461",
    "question": "What is associated with Duplication of the distal phalanx of the 4th finger?",
    "seeds": [
      "Duplication of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Mesoaxial hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04462",
    "question": "What is associated with GMPPB-related limb-girdle muscular dystrophy R19?",
    "seeds": [
      "GMPPB-related limb-girdle muscular dystrophy R19"
    ],
    "gold_answer": "Distal muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04463",
    "question": "What is associated with Abnormal ocular adnexa morphology?",
    "seeds": [
      "Abnormal ocular adnexa morphology"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04464",
    "question": "What is associated with Refractory drug response?",
    "seeds": [
      "Refractory drug response"
    ],
    "gold_answer": "Abnormal drug response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04465",
    "question": "What is associated with Faciocardiomelic syndrome?",
    "seeds": [
      "Faciocardiomelic syndrome"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04466",
    "question": "What is associated with Limited elbow flexion/extension?",
    "seeds": [
      "Limited elbow flexion/extension"
    ],
    "gold_answer": "Limited elbow extension",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04467",
    "question": "What is associated with Hyperandrogenism due to cortisone reductase deficiency?",
    "seeds": [
      "Hyperandrogenism due to cortisone reductase deficiency"
    ],
    "gold_answer": "Abnormal blood monovalent inorganic cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04468",
    "question": "What phenotype is associated with Hydatidiform mole, recurrent, 1?",
    "seeds": [
      "Hydatidiform mole, recurrent, 1"
    ],
    "gold_answer": "Helicobacter pylori infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04469",
    "question": "What is associated with Increased CSF xylitol concentration?",
    "seeds": [
      "Increased CSF xylitol concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04470",
    "question": "What is associated with Salivary gland oncocytoma?",
    "seeds": [
      "Salivary gland oncocytoma"
    ],
    "gold_answer": "Abnormal salivary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04471",
    "question": "What is associated with Scapholunate interval widening?",
    "seeds": [
      "Scapholunate interval widening"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04472",
    "question": "What phenotype is associated with Regional odontodysplasia?",
    "seeds": [
      "Regional odontodysplasia"
    ],
    "gold_answer": "Abnormality of the dental root",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04473",
    "question": "What is associated with Incomplete cleft soft palate?",
    "seeds": [
      "Incomplete cleft soft palate"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04474",
    "question": "What is associated with High-pitched cry?",
    "seeds": [
      "High-pitched cry"
    ],
    "gold_answer": "Abnormal cry",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04475",
    "question": "What is associated with Decreased neutrophil oxidative burst?",
    "seeds": [
      "Decreased neutrophil oxidative burst"
    ],
    "gold_answer": "Abnormal neutrophil physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04476",
    "question": "What is associated with 10-minute APGAR score of 1?",
    "seeds": [
      "10-minute APGAR score of 1"
    ],
    "gold_answer": "Low 10-minute APGAR score",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04477",
    "question": "What is associated with Autosomal erythropoietic protoporphyria?",
    "seeds": [
      "Autosomal erythropoietic protoporphyria"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04478",
    "question": "What is associated with Myopia 9?",
    "seeds": [
      "Myopia 9"
    ],
    "gold_answer": "Abnormality of refraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04479",
    "question": "What is associated with Acute necrotizing encephalopathy?",
    "seeds": [
      "Acute necrotizing encephalopathy"
    ],
    "gold_answer": "Acute encephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04480",
    "question": "What is associated with Immunodeficiency 126?",
    "seeds": [
      "Immunodeficiency 126"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04481",
    "question": "What is associated with Absent Birbeck granules in Langerhans cells?",
    "seeds": [
      "Absent Birbeck granules in Langerhans cells"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04482",
    "question": "What is associated with Decreased light- and dark-adapted electroretinogram amplitude?",
    "seeds": [
      "Decreased light- and dark-adapted electroretinogram amplitude"
    ],
    "gold_answer": "Abnormal electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04483",
    "question": "What is associated with Bilateral parasagittal parieto-occipital polymicrogyria?",
    "seeds": [
      "Bilateral parasagittal parieto-occipital polymicrogyria"
    ],
    "gold_answer": "Abnormality of the voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04484",
    "question": "What is associated with Narrow nasal tip?",
    "seeds": [
      "Narrow nasal tip"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04485",
    "question": "What is associated with Elevated circulating porphyrin concentration?",
    "seeds": [
      "Elevated circulating porphyrin concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04486",
    "question": "What is associated with Abnormality of the common coagulation pathway?",
    "seeds": [
      "Abnormality of the common coagulation pathway"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04487",
    "question": "What is associated with Multiple mitochondrial DNA deletions?",
    "seeds": [
      "Multiple mitochondrial DNA deletions"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04488",
    "question": "What is associated with Fetal cytomegalovirus syndrome?",
    "seeds": [
      "Fetal cytomegalovirus syndrome"
    ],
    "gold_answer": "Cholestasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04489",
    "question": "What is associated with Intellectual disability-lymphoid hypertrophy-macrocephaly syndrome?",
    "seeds": [
      "Intellectual disability-lymphoid hypertrophy-macrocephaly syndrome"
    ],
    "gold_answer": "ZBTB7A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04490",
    "question": "What is associated with Curved 1st metatarsal?",
    "seeds": [
      "Curved 1st metatarsal"
    ],
    "gold_answer": "Abnormality of the first metatarsal bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04491",
    "question": "What is associated with Absent metatarsal bone?",
    "seeds": [
      "Absent metatarsal bone"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04492",
    "question": "What is associated with Short mandibular condyles?",
    "seeds": [
      "Short mandibular condyles"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04493",
    "question": "What is associated with Abnormal cellular composition of bronchoalveolar fluid?",
    "seeds": [
      "Abnormal cellular composition of bronchoalveolar fluid"
    ],
    "gold_answer": "Abnormal bronchoalveolar lavage fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04494",
    "question": "What is associated with Hyperkalemic metabolic acidosis?",
    "seeds": [
      "Hyperkalemic metabolic acidosis"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04495",
    "question": "What phenotype is associated with Iatrogenic botulism?",
    "seeds": [
      "Iatrogenic botulism"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04496",
    "question": "What phenotype is associated with Diaphragmatic hernia 2?",
    "seeds": [
      "Diaphragmatic hernia 2"
    ],
    "gold_answer": "Agenesis of the diaphragm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04497",
    "question": "What phenotype is associated with Spermatogenic failure, Y-linked, 1?",
    "seeds": [
      "Spermatogenic failure, Y-linked, 1"
    ],
    "gold_answer": "Male infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04498",
    "question": "What is associated with Mitochondrial complex III deficiency, nuclear type 8?",
    "seeds": [
      "Mitochondrial complex III deficiency, nuclear type 8"
    ],
    "gold_answer": "Brain atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04499",
    "question": "What is associated with Saccadic intrusion?",
    "seeds": [
      "Saccadic intrusion"
    ],
    "gold_answer": "Abnormal saccadic eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04500",
    "question": "What phenotype is associated with Ulnar/fibula ray defect-brachydactyly syndrome?",
    "seeds": [
      "Ulnar/fibula ray defect-brachydactyly syndrome"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04501",
    "question": "What is associated with Myopathy, myosin storage, autosomal recessive?",
    "seeds": [
      "Myopathy, myosin storage, autosomal recessive"
    ],
    "gold_answer": "Muscle hypertrophy of the lower extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04502",
    "question": "What is associated with Broad thumb?",
    "seeds": [
      "Broad thumb"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04503",
    "question": "What is associated with Hypotrichosis 3?",
    "seeds": [
      "Hypotrichosis 3"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04504",
    "question": "What is associated with GM1-ganglioside accumulation?",
    "seeds": [
      "GM1-ganglioside accumulation"
    ],
    "gold_answer": "Ganglioside accumulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04505",
    "question": "What is associated with Urinary urgency?",
    "seeds": [
      "Urinary urgency"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04506",
    "question": "What is associated with Abnormal cortical peritubular capillary morphology?",
    "seeds": [
      "Abnormal cortical peritubular capillary morphology"
    ],
    "gold_answer": "Abnormal renal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04507",
    "question": "What phenotype is associated with Question mark ears, isolated?",
    "seeds": [
      "Question mark ears, isolated"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04508",
    "question": "What is associated with Prominent subcalcaneal fat pad?",
    "seeds": [
      "Prominent subcalcaneal fat pad"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04509",
    "question": "What is associated with Atrial fibrillation?",
    "seeds": [
      "Atrial fibrillation"
    ],
    "gold_answer": "Supraventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04510",
    "question": "What phenotype is associated with Hypotrichosis 3?",
    "seeds": [
      "Hypotrichosis 3"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04511",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 39?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 39"
    ],
    "gold_answer": "Attention deficit hyperactivity disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04512",
    "question": "What is associated with Sclerosis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Sclerosis of middle phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04513",
    "question": "What is associated with Horizontal incomitant strabismus?",
    "seeds": [
      "Horizontal incomitant strabismus"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04514",
    "question": "What is associated with Methylmalonic acidemia with homocystinuria, type cblC?",
    "seeds": [
      "Methylmalonic acidemia with homocystinuria, type cblC"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04515",
    "question": "What is associated with Pubertal developmental failure in females?",
    "seeds": [
      "Pubertal developmental failure in females"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04516",
    "question": "What is associated with Anti-cytosolic-5-nucleotidase-1A antibody positivity?",
    "seeds": [
      "Anti-cytosolic-5-nucleotidase-1A antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04517",
    "question": "What is associated with Koebner Phenomenon?",
    "seeds": [
      "Koebner Phenomenon"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04518",
    "question": "What is associated with Peroxisome biogenesis disorder 10B?",
    "seeds": [
      "Peroxisome biogenesis disorder 10B"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04519",
    "question": "What is associated with Urate-Binding globulin, decrease in?",
    "seeds": [
      "Urate-Binding globulin, decrease in"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04520",
    "question": "What is associated with Beta-mannosidosis?",
    "seeds": [
      "Beta-mannosidosis"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04521",
    "question": "What phenotype is associated with Helsmoortel-van der Aa syndrome?",
    "seeds": [
      "Helsmoortel-van der Aa syndrome"
    ],
    "gold_answer": "Eyelid coloboma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04522",
    "question": "What is associated with Perineal hypospadias?",
    "seeds": [
      "Perineal hypospadias"
    ],
    "gold_answer": "Displacement of the urethral meatus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04523",
    "question": "What is associated with Angulation of penis?",
    "seeds": [
      "Angulation of penis"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04524",
    "question": "What phenotype is associated with Mannose 6-phosphate receptor recognition defect, Lebanese type?",
    "seeds": [
      "Mannose 6-phosphate receptor recognition defect, Lebanese type"
    ],
    "gold_answer": "Abnormality of lysosomal metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04525",
    "question": "What is associated with Glutathionuria?",
    "seeds": [
      "Glutathionuria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04526",
    "question": "What is associated with Facial paresis, hereditary congenital, 1?",
    "seeds": [
      "Facial paresis, hereditary congenital, 1"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04527",
    "question": "What is associated with Absent epiphysis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Absent epiphysis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal 3rd finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04528",
    "question": "What is associated with Glue ear?",
    "seeds": [
      "Glue ear"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04529",
    "question": "What is associated with Restless legs?",
    "seeds": [
      "Restless legs"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04530",
    "question": "What is associated with 6-@phosphogluconolactonase deficiency?",
    "seeds": [
      "6-@phosphogluconolactonase deficiency"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04531",
    "question": "What is associated with Irregular epiphyses of the proximal phalanges of the hand?",
    "seeds": [
      "Irregular epiphyses of the proximal phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04532",
    "question": "What phenotype is associated with Wilms tumor 6?",
    "seeds": [
      "Wilms tumor 6"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04533",
    "question": "What phenotype is associated with Spinocerebellar ataxia type 17?",
    "seeds": [
      "Spinocerebellar ataxia type 17"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04534",
    "question": "What phenotype is associated with Camptodactyly syndrome, Guadalajara type 1?",
    "seeds": [
      "Camptodactyly syndrome, Guadalajara type 1"
    ],
    "gold_answer": "Sacral dimple",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04535",
    "question": "What is associated with Hypocalcemia?",
    "seeds": [
      "Hypocalcemia"
    ],
    "gold_answer": "Abnormal blood inorganic cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04536",
    "question": "What is associated with Neurodevelopmental disorder with epilepsy and brain atrophy?",
    "seeds": [
      "Neurodevelopmental disorder with epilepsy and brain atrophy"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04537",
    "question": "What phenotype is associated with Epidermolysis bullosa simplex, Dowling-Meara type?",
    "seeds": [
      "Epidermolysis bullosa simplex, Dowling-Meara type"
    ],
    "gold_answer": "Tonofilament clumping",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04538",
    "question": "What phenotype is associated with FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 5?",
    "seeds": [
      "FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 5"
    ],
    "gold_answer": "Persistence of hemoglobin F",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04539",
    "question": "What is associated with Radial head subluxation?",
    "seeds": [
      "Radial head subluxation"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04540",
    "question": "What phenotype is associated with Preauricular fistulae, congenital?",
    "seeds": [
      "Preauricular fistulae, congenital"
    ],
    "gold_answer": "Preauricular pit",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04541",
    "question": "What is associated with Pachyonychia congenita?",
    "seeds": [
      "Pachyonychia congenita"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04542",
    "question": "What is associated with Borderline personality disorder?",
    "seeds": [
      "Borderline personality disorder"
    ],
    "gold_answer": "Personality disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04543",
    "question": "What is associated with Spectrin-associated autosomal recessive cerebellar ataxia?",
    "seeds": [
      "Spectrin-associated autosomal recessive cerebellar ataxia"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04544",
    "question": "What is associated with Hereditary cerebral amyloid angiopathy?",
    "seeds": [
      "Hereditary cerebral amyloid angiopathy"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04545",
    "question": "What is associated with Pseudoepiphysis of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Pseudoepiphysis of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Pseudoepiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04546",
    "question": "What is associated with Digital ischemia?",
    "seeds": [
      "Digital ischemia"
    ],
    "gold_answer": "Abnormal arterial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04547",
    "question": "What is associated with Metaphyseal spurs?",
    "seeds": [
      "Metaphyseal spurs"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04548",
    "question": "What is associated with Trisomy 18 syndrome?",
    "seeds": [
      "Trisomy 18 syndrome"
    ],
    "gold_answer": "FLT4",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_04549",
    "question": "What is associated with Brachyolmia type 2?",
    "seeds": [
      "Brachyolmia type 2"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04550",
    "question": "What is associated with Marginal corneal dystrophy?",
    "seeds": [
      "Marginal corneal dystrophy"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04551",
    "question": "What is associated with Flared distal tibial metaphysis?",
    "seeds": [
      "Flared distal tibial metaphysis"
    ],
    "gold_answer": "Flared lower limb metaphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04552",
    "question": "What is associated with Pelizaeus-Merzbacher disease, connatal form?",
    "seeds": [
      "Pelizaeus-Merzbacher disease, connatal form"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04553",
    "question": "What is associated with Sleep-interrupting?",
    "seeds": [
      "Sleep-interrupting"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04554",
    "question": "What phenotype is associated with Somatomammotropinoma?",
    "seeds": [
      "Somatomammotropinoma"
    ],
    "gold_answer": "Diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04555",
    "question": "What is associated with Multiple exostoses with spastic tetraparesis?",
    "seeds": [
      "Multiple exostoses with spastic tetraparesis"
    ],
    "gold_answer": "Appendicular spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04556",
    "question": "What is associated with Michaelis-Gutmann bodies?",
    "seeds": [
      "Michaelis-Gutmann bodies"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04557",
    "question": "What is associated with Thumb deformity-alopecia-pigmentation anomaly syndrome?",
    "seeds": [
      "Thumb deformity-alopecia-pigmentation anomaly syndrome"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04558",
    "question": "What is associated with Small epiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Small epiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Small epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04559",
    "question": "What phenotype is associated with SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 6?",
    "seeds": [
      "SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 6"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04560",
    "question": "What phenotype is associated with Premature ovarian failure 5?",
    "seeds": [
      "Premature ovarian failure 5"
    ],
    "gold_answer": "Reduced antral follicle count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04561",
    "question": "What is associated with Ileus?",
    "seeds": [
      "Ileus"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04562",
    "question": "What phenotype is associated with Cholestasis, progressive familial intrahepatic 4?",
    "seeds": [
      "Cholestasis, progressive familial intrahepatic 4"
    ],
    "gold_answer": "Intrahepatic cholestasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04563",
    "question": "What is associated with Ectopic accessory finger-like appendage?",
    "seeds": [
      "Ectopic accessory finger-like appendage"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04564",
    "question": "What is associated with Carney triad?",
    "seeds": [
      "Carney triad"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04565",
    "question": "What phenotype is associated with Leptin deficiency or dysfunction?",
    "seeds": [
      "Leptin deficiency or dysfunction"
    ],
    "gold_answer": "Decreased serum leptin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04566",
    "question": "What is associated with Abnormal cartilage collagen?",
    "seeds": [
      "Abnormal cartilage collagen"
    ],
    "gold_answer": "Abnormal cartilage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04567",
    "question": "What is associated with Early chronotype?",
    "seeds": [
      "Early chronotype"
    ],
    "gold_answer": "Sleep-wake cycle disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04568",
    "question": "What phenotype is associated with Basal ganglia calcification, idiopathic, 8, autosomal recessive?",
    "seeds": [
      "Basal ganglia calcification, idiopathic, 8, autosomal recessive"
    ],
    "gold_answer": "Limb ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04569",
    "question": "What phenotype is associated with Gamma-sarcoglycan-related limb-girdle muscular dystrophy R5?",
    "seeds": [
      "Gamma-sarcoglycan-related limb-girdle muscular dystrophy R5"
    ],
    "gold_answer": "Right ventricular hypertrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04570",
    "question": "What is associated with Trehalase deficiency?",
    "seeds": [
      "Trehalase deficiency"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04571",
    "question": "What is associated with Bimanual synkinesia?",
    "seeds": [
      "Bimanual synkinesia"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04572",
    "question": "What is associated with RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic?",
    "seeds": [
      "RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04573",
    "question": "What is associated with Esotropia?",
    "seeds": [
      "Esotropia"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04574",
    "question": "What is associated with Absent neutrophil lactoferrin?",
    "seeds": [
      "Absent neutrophil lactoferrin"
    ],
    "gold_answer": "Abnormal neutrophil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04575",
    "question": "What is associated with Seesaw nystagmus?",
    "seeds": [
      "Seesaw nystagmus"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04576",
    "question": "What is associated with Decreased motor nerve conduction velocity?",
    "seeds": [
      "Decreased motor nerve conduction velocity"
    ],
    "gold_answer": "Abnormal nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04577",
    "question": "What is associated with Hot water-induced seizure?",
    "seeds": [
      "Hot water-induced seizure"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04578",
    "question": "What is associated with Prominent scalp veins?",
    "seeds": [
      "Prominent scalp veins"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04579",
    "question": "What is associated with FGFR2-related bent bone dysplasia?",
    "seeds": [
      "FGFR2-related bent bone dysplasia"
    ],
    "gold_answer": "Abnormality of the calf",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04580",
    "question": "What is associated with Abnormal cricoid cartilage morphology?",
    "seeds": [
      "Abnormal cricoid cartilage morphology"
    ],
    "gold_answer": "Abnormal larynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04581",
    "question": "What is associated with Abnormal circulating membrane cofactor protein concentration?",
    "seeds": [
      "Abnormal circulating membrane cofactor protein concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04582",
    "question": "What is associated with 4H leukodystrophy?",
    "seeds": [
      "4H leukodystrophy"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04583",
    "question": "What is associated with Megaloblastic erythroid hyperplasia?",
    "seeds": [
      "Megaloblastic erythroid hyperplasia"
    ],
    "gold_answer": "Erythroid hyperplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04584",
    "question": "What phenotype is associated with Chylomicronemia, familial, due to circulating inhibitor of lipoproteinlipase?",
    "seeds": [
      "Chylomicronemia, familial, due to circulating inhibitor of lipoproteinlipase"
    ],
    "gold_answer": "Recurrent pancreatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04585",
    "question": "What is associated with INTUSSUSCEPTION?",
    "seeds": [
      "INTUSSUSCEPTION"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04586",
    "question": "What is associated with Pes planus?",
    "seeds": [
      "Pes planus"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04587",
    "question": "What is associated with Pancreatic abscess?",
    "seeds": [
      "Pancreatic abscess"
    ],
    "gold_answer": "Abnormal pancreas morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04588",
    "question": "What is associated with Progressive scapulohumeroperoneal distal myopathy?",
    "seeds": [
      "Progressive scapulohumeroperoneal distal myopathy"
    ],
    "gold_answer": "ACTA1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04589",
    "question": "What is associated with Sclerotic humeral metaphysis with longitudinal striations?",
    "seeds": [
      "Sclerotic humeral metaphysis with longitudinal striations"
    ],
    "gold_answer": "Sclerotic humeral metaphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04590",
    "question": "What is associated with Fragmentation of the epiphysis of the proximal phalanx of the thumb?",
    "seeds": [
      "Fragmentation of the epiphysis of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04591",
    "question": "What is associated with Arthrogryposis multiplex congenita, neurogenic, with agenesis of the corpus callosum?",
    "seeds": [
      "Arthrogryposis multiplex congenita, neurogenic, with agenesis of the corpus callosum"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04592",
    "question": "What is associated with Febrile status epilepticus?",
    "seeds": [
      "Febrile status epilepticus"
    ],
    "gold_answer": "Complex febrile seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04593",
    "question": "What phenotype is associated with Marbach-Schaaf neurodevelopmental syndrome?",
    "seeds": [
      "Marbach-Schaaf neurodevelopmental syndrome"
    ],
    "gold_answer": "Enuresis nocturna",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04594",
    "question": "What is associated with Juvenile rheumatoid arthritis?",
    "seeds": [
      "Juvenile rheumatoid arthritis"
    ],
    "gold_answer": "Abnormal phalangeal joint morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04595",
    "question": "What is associated with Generalized morning stiffness?",
    "seeds": [
      "Generalized morning stiffness"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04596",
    "question": "What is associated with Anti-LABD97 antibody positivity?",
    "seeds": [
      "Anti-LABD97 antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04597",
    "question": "What is associated with Microphthalmia, isolated 7?",
    "seeds": [
      "Microphthalmia, isolated 7"
    ],
    "gold_answer": "Aplasia/Hypoplasia affecting the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04598",
    "question": "What is associated with Palmoplantar cutis laxa?",
    "seeds": [
      "Palmoplantar cutis laxa"
    ],
    "gold_answer": "Cutis laxa",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04599",
    "question": "What is associated with Bethlem myopathy 1A?",
    "seeds": [
      "Bethlem myopathy 1A"
    ],
    "gold_answer": "Foot joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04600",
    "question": "What phenotype is associated with Angelman syndrome due to imprinting defect in 15q11-q13?",
    "seeds": [
      "Angelman syndrome due to imprinting defect in 15q11-q13"
    ],
    "gold_answer": "Drooling",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04601",
    "question": "What phenotype is associated with Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome?",
    "seeds": [
      "Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04602",
    "question": "What is associated with Enlarged Eustachian valve?",
    "seeds": [
      "Enlarged Eustachian valve"
    ],
    "gold_answer": "Abnormal venous morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04603",
    "question": "What is associated with Branchiootic syndrome 2?",
    "seeds": [
      "Branchiootic syndrome 2"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04604",
    "question": "What is associated with Tactile sensory seeking?",
    "seeds": [
      "Tactile sensory seeking"
    ],
    "gold_answer": "Sensory seeking",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04605",
    "question": "What is associated with Abnormal circulating amylase concentration?",
    "seeds": [
      "Abnormal circulating amylase concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04606",
    "question": "What is associated with Abnormal CSF isoleucine concentration?",
    "seeds": [
      "Abnormal CSF isoleucine concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04607",
    "question": "What is associated with Recurrent aspiration pneumonia?",
    "seeds": [
      "Recurrent aspiration pneumonia"
    ],
    "gold_answer": "Pneumonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04608",
    "question": "What phenotype is associated with Cortical blindness-intellectual disability-polydactyly syndrome?",
    "seeds": [
      "Cortical blindness-intellectual disability-polydactyly syndrome"
    ],
    "gold_answer": "Optic nerve hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04609",
    "question": "What phenotype is associated with Alsahan-Harris syndrome?",
    "seeds": [
      "Alsahan-Harris syndrome"
    ],
    "gold_answer": "Flat occiput",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04610",
    "question": "What is associated with Thickened helices?",
    "seeds": [
      "Thickened helices"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04611",
    "question": "What is associated with Dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities?",
    "seeds": [
      "Dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04612",
    "question": "What is associated with Clonal T cell receptor rearrangement?",
    "seeds": [
      "Clonal T cell receptor rearrangement"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04613",
    "question": "What is associated with Jaw mass?",
    "seeds": [
      "Jaw mass"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04614",
    "question": "What is associated with Left ventricular dilatation?",
    "seeds": [
      "Left ventricular dilatation"
    ],
    "gold_answer": "Abnormal left ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04615",
    "question": "What is associated with Reticulated skin pigmentation?",
    "seeds": [
      "Reticulated skin pigmentation"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04616",
    "question": "What is associated with Abnormal portal venous system morphology?",
    "seeds": [
      "Abnormal portal venous system morphology"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04617",
    "question": "What phenotype is associated with Lumbar stenosis, familial?",
    "seeds": [
      "Lumbar stenosis, familial"
    ],
    "gold_answer": "Lumbar spinal canal stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04618",
    "question": "What is associated with Ophthalmoplegia, progressive, with scrotal tongue and mental deficiency?",
    "seeds": [
      "Ophthalmoplegia, progressive, with scrotal tongue and mental deficiency"
    ],
    "gold_answer": "Ophthalmoparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04619",
    "question": "What phenotype is associated with Cerebral angiopathy, dysphoric?",
    "seeds": [
      "Cerebral angiopathy, dysphoric"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04620",
    "question": "What is associated with Mannosidosis, beta?",
    "seeds": [
      "Mannosidosis, beta"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04621",
    "question": "What is associated with Mucopolysaccharidosis type 3?",
    "seeds": [
      "Mucopolysaccharidosis type 3"
    ],
    "gold_answer": "Sleep-related breathing disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04622",
    "question": "What phenotype is associated with Nephronophthisis 4?",
    "seeds": [
      "Nephronophthisis 4"
    ],
    "gold_answer": "Renal tubular atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04623",
    "question": "What is associated with Positive urine Legionella pneumophila antigen test?",
    "seeds": [
      "Positive urine Legionella pneumophila antigen test"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04624",
    "question": "What is associated with Patchy reduction of bone mineral density?",
    "seeds": [
      "Patchy reduction of bone mineral density"
    ],
    "gold_answer": "Abnormal bone structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04625",
    "question": "What is associated with Spastic paraplegia 48, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 48, autosomal recessive"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04626",
    "question": "What is associated with Nailfold capillary tortuosity?",
    "seeds": [
      "Nailfold capillary tortuosity"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04627",
    "question": "What is associated with Single fiber EMG abnormality?",
    "seeds": [
      "Single fiber EMG abnormality"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04628",
    "question": "What is associated with Preretinal hemorrhage?",
    "seeds": [
      "Preretinal hemorrhage"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04629",
    "question": "What is associated with 46,xx sex reversal 3?",
    "seeds": [
      "46,xx sex reversal 3"
    ],
    "gold_answer": "Abnormal sex determination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04630",
    "question": "What is associated with Functional intestinal obstruction?",
    "seeds": [
      "Functional intestinal obstruction"
    ],
    "gold_answer": "Gastrointestinal obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04631",
    "question": "What is associated with Erythematous macule?",
    "seeds": [
      "Erythematous macule"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04632",
    "question": "What is associated with Collectionism?",
    "seeds": [
      "Collectionism"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04633",
    "question": "What is associated with Spinocerebellar ataxia 29, congenital nonprogressive?",
    "seeds": [
      "Spinocerebellar ataxia 29, congenital nonprogressive"
    ],
    "gold_answer": "Slanting of the palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04634",
    "question": "What is associated with Medial deviation of the foot?",
    "seeds": [
      "Medial deviation of the foot"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04635",
    "question": "What is associated with Digital flexor tenosynovitis?",
    "seeds": [
      "Digital flexor tenosynovitis"
    ],
    "gold_answer": "Tenosynovitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04636",
    "question": "What is associated with Increased urine isobutyrylglycine concentration?",
    "seeds": [
      "Increased urine isobutyrylglycine concentration"
    ],
    "gold_answer": "Increased urine proteinogenic amino acid derivative level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04637",
    "question": "What is associated with Abnormality of the round window?",
    "seeds": [
      "Abnormality of the round window"
    ],
    "gold_answer": "Abnormality of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04638",
    "question": "What is associated with Narrow joint spaces of the elbow?",
    "seeds": [
      "Narrow joint spaces of the elbow"
    ],
    "gold_answer": "Abnormality of the joint spaces of the elbow",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04639",
    "question": "What is associated with Severe constriction of peripheral visual field?",
    "seeds": [
      "Severe constriction of peripheral visual field"
    ],
    "gold_answer": "Constriction of peripheral visual field",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04640",
    "question": "What is associated with Combined immunodeficiency due to IL21R deficiency?",
    "seeds": [
      "Combined immunodeficiency due to IL21R deficiency"
    ],
    "gold_answer": "IL21R",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_04641",
    "question": "What phenotype is associated with Aymé-Gripp syndrome?",
    "seeds": [
      "Aymé-Gripp syndrome"
    ],
    "gold_answer": "Abnormality of primary molar morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04642",
    "question": "What phenotype is associated with Baller-Gerold syndrome?",
    "seeds": [
      "Baller-Gerold syndrome"
    ],
    "gold_answer": "Dermal atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04643",
    "question": "What is associated with Subacute cutaneous lupus erythematosus?",
    "seeds": [
      "Subacute cutaneous lupus erythematosus"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04644",
    "question": "What is associated with Insect stings, hypersensitivity to?",
    "seeds": [
      "Insect stings, hypersensitivity to"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04645",
    "question": "What is associated with Generalized hypopigmentation of hair?",
    "seeds": [
      "Generalized hypopigmentation of hair"
    ],
    "gold_answer": "Abnormality of hair pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04646",
    "question": "What is associated with NIK deficiency?",
    "seeds": [
      "NIK deficiency"
    ],
    "gold_answer": "MAP3K14",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_04647",
    "question": "What is associated with Intellectual disability-seizures-macrocephaly-obesity syndrome?",
    "seeds": [
      "Intellectual disability-seizures-macrocephaly-obesity syndrome"
    ],
    "gold_answer": "Abnormal QRS complex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04648",
    "question": "What is associated with Elevated circulating apolipoprotein A-II concentration?",
    "seeds": [
      "Elevated circulating apolipoprotein A-II concentration"
    ],
    "gold_answer": "Increased circulating apolipoprotein circulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04649",
    "question": "What is associated with Limited ankle dorsiflexion?",
    "seeds": [
      "Limited ankle dorsiflexion"
    ],
    "gold_answer": "Abnormal ankle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04650",
    "question": "What is associated with Enlarged flash visual evoked potentials?",
    "seeds": [
      "Enlarged flash visual evoked potentials"
    ],
    "gold_answer": "Abnormal flash visual evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04651",
    "question": "What is associated with Advanced tarsal ossification?",
    "seeds": [
      "Advanced tarsal ossification"
    ],
    "gold_answer": "Abnormal tarsal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04652",
    "question": "What is associated with Elevated circulating beta-mannosidase activity?",
    "seeds": [
      "Elevated circulating beta-mannosidase activity"
    ],
    "gold_answer": "Abnormal circulating beta-mannosidase activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04653",
    "question": "What is associated with Anti-angiotensin receptor type-1 antibody positivity?",
    "seeds": [
      "Anti-angiotensin receptor type-1 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04654",
    "question": "What phenotype is associated with Congenital heart defects and skeletal malformations syndrome?",
    "seeds": [
      "Congenital heart defects and skeletal malformations syndrome"
    ],
    "gold_answer": "Hypoplastic left ventricle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04655",
    "question": "What is associated with Endolymphatic sac tumor?",
    "seeds": [
      "Endolymphatic sac tumor"
    ],
    "gold_answer": "Neoplasm of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04656",
    "question": "What is associated with Abnormality of the radial head?",
    "seeds": [
      "Abnormality of the radial head"
    ],
    "gold_answer": "Abnormal morphology of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04657",
    "question": "What phenotype is associated with AICA-ribosiduria due to ATIC deficiency?",
    "seeds": [
      "AICA-ribosiduria due to ATIC deficiency"
    ],
    "gold_answer": "Wide mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04658",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 6?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 6"
    ],
    "gold_answer": "Abnormal pyramidal sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04659",
    "question": "What is associated with Partial duplication of the phalanges of the hallux?",
    "seeds": [
      "Partial duplication of the phalanges of the hallux"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04660",
    "question": "What is associated with Small epiphyses of the 5th toe?",
    "seeds": [
      "Small epiphyses of the 5th toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04661",
    "question": "What is associated with Abnormality of the epiphysis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Abnormality of the epiphysis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal middle phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04662",
    "question": "What is associated with Granulomatous arteriolitis of the arteriolar intima/media?",
    "seeds": [
      "Granulomatous arteriolitis of the arteriolar intima/media"
    ],
    "gold_answer": "Renal intimal/medial arteriolitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04663",
    "question": "What is associated with Cerebral palsy, spastic quadriplegic, 3?",
    "seeds": [
      "Cerebral palsy, spastic quadriplegic, 3"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04664",
    "question": "What is associated with Palmoplantar keratoderma, nonepidermolytic, focal 2?",
    "seeds": [
      "Palmoplantar keratoderma, nonepidermolytic, focal 2"
    ],
    "gold_answer": "Plantar hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04665",
    "question": "What is associated with Solid pulmonary nodule?",
    "seeds": [
      "Solid pulmonary nodule"
    ],
    "gold_answer": "Pulmonary nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04666",
    "question": "What is associated with NESCAV syndrome?",
    "seeds": [
      "NESCAV syndrome"
    ],
    "gold_answer": "Hyperactivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04667",
    "question": "What phenotype is associated with Polycystic kidney disease 2?",
    "seeds": [
      "Polycystic kidney disease 2"
    ],
    "gold_answer": "Multiple renal cysts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04668",
    "question": "What is associated with Increased circulating carnosine concentration?",
    "seeds": [
      "Increased circulating carnosine concentration"
    ],
    "gold_answer": "Abnormal circulating carnosine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04669",
    "question": "What is associated with Cystinosis, adult nonnephropathic?",
    "seeds": [
      "Cystinosis, adult nonnephropathic"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04670",
    "question": "What is associated with Contracture of the metacarpophalangeal joint of the 2nd finger?",
    "seeds": [
      "Contracture of the metacarpophalangeal joint of the 2nd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04671",
    "question": "What is associated with Skewed maternal X inactivation?",
    "seeds": [
      "Skewed maternal X inactivation"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04672",
    "question": "What is associated with Arthrogryposis multiplex congenita 6?",
    "seeds": [
      "Arthrogryposis multiplex congenita 6"
    ],
    "gold_answer": "Congenital contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04673",
    "question": "What phenotype is associated with Peripheral dysostosis?",
    "seeds": [
      "Peripheral dysostosis"
    ],
    "gold_answer": "Short phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04674",
    "question": "What is associated with Antiparietal cell antibody positivity?",
    "seeds": [
      "Antiparietal cell antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04675",
    "question": "What is associated with Abnormal external ear cartilage morphology?",
    "seeds": [
      "Abnormal external ear cartilage morphology"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04676",
    "question": "What is associated with Primary hepatic neuroendocrine carcinoma?",
    "seeds": [
      "Primary hepatic neuroendocrine carcinoma"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04677",
    "question": "What is associated with Long thorax?",
    "seeds": [
      "Long thorax"
    ],
    "gold_answer": "Enlarged thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04678",
    "question": "What is associated with Accessory scrotum?",
    "seeds": [
      "Accessory scrotum"
    ],
    "gold_answer": "Abnormal scrotum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04679",
    "question": "What is associated with Shiga toxin-associated hemolytic uremic syndrome?",
    "seeds": [
      "Shiga toxin-associated hemolytic uremic syndrome"
    ],
    "gold_answer": "Anorectal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04680",
    "question": "What is associated with Hippocampal sclerosis?",
    "seeds": [
      "Hippocampal sclerosis"
    ],
    "gold_answer": "Abnormal glial cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04681",
    "question": "What is associated with Elevated urinary succinylaminoimidazole carboxamide riboside level?",
    "seeds": [
      "Elevated urinary succinylaminoimidazole carboxamide riboside level"
    ],
    "gold_answer": "Abnormal urinary nucleobase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04682",
    "question": "What phenotype is associated with Deafness, congenital neurosensory, autosomal recessive 40?",
    "seeds": [
      "Deafness, congenital neurosensory, autosomal recessive 40"
    ],
    "gold_answer": "Prelingual sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04683",
    "question": "What is associated with Avoidance of emotional intimacy?",
    "seeds": [
      "Avoidance of emotional intimacy"
    ],
    "gold_answer": "Abnormal social behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04684",
    "question": "What is associated with Delayed myelination?",
    "seeds": [
      "Delayed myelination"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04685",
    "question": "What phenotype is associated with Hypoparathyroidism, familial isolated?",
    "seeds": [
      "Hypoparathyroidism, familial isolated"
    ],
    "gold_answer": "Hypocalcemic seizures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04686",
    "question": "What is associated with Abnormal limb bone morphology?",
    "seeds": [
      "Abnormal limb bone morphology"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04687",
    "question": "What is associated with Oculocutaneous albinism type 1A?",
    "seeds": [
      "Oculocutaneous albinism type 1A"
    ],
    "gold_answer": "Abnormal brain-evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04688",
    "question": "What is associated with Hyperpituitarism?",
    "seeds": [
      "Hyperpituitarism"
    ],
    "gold_answer": "Abnormal pituitary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04689",
    "question": "What is associated with Reduced circulating fibronectin level?",
    "seeds": [
      "Reduced circulating fibronectin level"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04690",
    "question": "What is associated with Anti-SEZ6L2 antibody?",
    "seeds": [
      "Anti-SEZ6L2 antibody"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04691",
    "question": "What phenotype is associated with Mitochondrial myopathy with reversible cytochrome C oxidase deficiency?",
    "seeds": [
      "Mitochondrial myopathy with reversible cytochrome C oxidase deficiency"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04692",
    "question": "What is associated with Ear antitragus, tag at base of?",
    "seeds": [
      "Ear antitragus, tag at base of"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04693",
    "question": "What phenotype is associated with Lissencephaly 3?",
    "seeds": [
      "Lissencephaly 3"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04694",
    "question": "What is associated with Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1?",
    "seeds": [
      "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1"
    ],
    "gold_answer": "Tremor by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04695",
    "question": "What is associated with Tooth agenesis, selective, 4?",
    "seeds": [
      "Tooth agenesis, selective, 4"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04696",
    "question": "What is associated with Congenital finger flexion contractures?",
    "seeds": [
      "Congenital finger flexion contractures"
    ],
    "gold_answer": "Abnormal phalangeal joint morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04697",
    "question": "What is associated with Focal autonomic seizure with pupillary dilation/constriction?",
    "seeds": [
      "Focal autonomic seizure with pupillary dilation/constriction"
    ],
    "gold_answer": "Focal autonomic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04698",
    "question": "What is associated with Cervical clear cell adenocarcinoma?",
    "seeds": [
      "Cervical clear cell adenocarcinoma"
    ],
    "gold_answer": "Vaginal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04699",
    "question": "What is associated with Pemphigoid gestationis?",
    "seeds": [
      "Pemphigoid gestationis"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04700",
    "question": "What is associated with Ankyloblepharon filiforme adnatum and cleft palate?",
    "seeds": [
      "Ankyloblepharon filiforme adnatum and cleft palate"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04701",
    "question": "What phenotype is associated with Kleefstra syndrome 2?",
    "seeds": [
      "Kleefstra syndrome 2"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04702",
    "question": "What is associated with Barrel-shaped chest?",
    "seeds": [
      "Barrel-shaped chest"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04703",
    "question": "What is associated with Constant exotropia?",
    "seeds": [
      "Constant exotropia"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04704",
    "question": "What is associated with Episodic ataxia type 1?",
    "seeds": [
      "Episodic ataxia type 1"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04705",
    "question": "What is associated with Bronchial atresia?",
    "seeds": [
      "Bronchial atresia"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04706",
    "question": "What is associated with Aplasia/Hypoplasia of the cerebrum?",
    "seeds": [
      "Aplasia/Hypoplasia of the cerebrum"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04707",
    "question": "What is associated with Retinitis pigmentosa 32?",
    "seeds": [
      "Retinitis pigmentosa 32"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04708",
    "question": "What is associated with Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies?",
    "seeds": [
      "Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies"
    ],
    "gold_answer": "Hyperbilirubinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04709",
    "question": "What is associated with Elevated urine propionylglycine level?",
    "seeds": [
      "Elevated urine propionylglycine level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04710",
    "question": "What is associated with Hopelessness?",
    "seeds": [
      "Hopelessness"
    ],
    "gold_answer": "Abnormal preoccupation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04711",
    "question": "What is associated with Malignant epithelial tumor of salivary glands?",
    "seeds": [
      "Malignant epithelial tumor of salivary glands"
    ],
    "gold_answer": "PRKD1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04712",
    "question": "What is associated with Short middle phalanx of the 4th toe?",
    "seeds": [
      "Short middle phalanx of the 4th toe"
    ],
    "gold_answer": "Short phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04713",
    "question": "What is associated with Ulnar translocation of the carpus?",
    "seeds": [
      "Ulnar translocation of the carpus"
    ],
    "gold_answer": "Abnormal carpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04714",
    "question": "What is associated with Symphalangism, proximal, 1B?",
    "seeds": [
      "Symphalangism, proximal, 1B"
    ],
    "gold_answer": "Proximal finger symphalangism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04715",
    "question": "What is associated with Abnormal nasal mucosa morphology?",
    "seeds": [
      "Abnormal nasal mucosa morphology"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04716",
    "question": "What is associated with Self-biting?",
    "seeds": [
      "Self-biting"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04717",
    "question": "What phenotype is associated with Thyroid hormone resistance, generalized, autosomal recessive?",
    "seeds": [
      "Thyroid hormone resistance, generalized, autosomal recessive"
    ],
    "gold_answer": "Increased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04718",
    "question": "What is associated with Cervical C5/C6 vertebrae fusion?",
    "seeds": [
      "Cervical C5/C6 vertebrae fusion"
    ],
    "gold_answer": "Vertebral fusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04719",
    "question": "What is associated with Parietal encephalocele?",
    "seeds": [
      "Parietal encephalocele"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04720",
    "question": "What is associated with Dorsal flexion contracture of the ankle?",
    "seeds": [
      "Dorsal flexion contracture of the ankle"
    ],
    "gold_answer": "Abnormal ankle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04721",
    "question": "What is associated with Abnormality of the cochlear nerve?",
    "seeds": [
      "Abnormality of the cochlear nerve"
    ],
    "gold_answer": "Abnormal inner ear nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04722",
    "question": "What is associated with Positive CSF JC-virus antibody positivity?",
    "seeds": [
      "Positive CSF JC-virus antibody positivity"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04723",
    "question": "What is associated with Fibrous syngnathia?",
    "seeds": [
      "Fibrous syngnathia"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04724",
    "question": "What is associated with Transverse terminal lower limb defect?",
    "seeds": [
      "Transverse terminal lower limb defect"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04725",
    "question": "What is associated with Fatigable weakness of swallowing muscles?",
    "seeds": [
      "Fatigable weakness of swallowing muscles"
    ],
    "gold_answer": "Fatigable weakness of bulbar muscles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04726",
    "question": "What is associated with Corneal transplant history?",
    "seeds": [
      "Corneal transplant history"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04727",
    "question": "What is associated with Abnormal transition from sleep to wakefulness?",
    "seeds": [
      "Abnormal transition from sleep to wakefulness"
    ],
    "gold_answer": "Sleep-wake transition abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04728",
    "question": "What is associated with Polysyndactyly with cardiac malformation?",
    "seeds": [
      "Polysyndactyly with cardiac malformation"
    ],
    "gold_answer": "Abnormal nostril morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04729",
    "question": "What is associated with Decreased prothrombin time?",
    "seeds": [
      "Decreased prothrombin time"
    ],
    "gold_answer": "Abnormal prothrombin time",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04730",
    "question": "What is associated with Left ventricular noncompaction cardiomyopathy?",
    "seeds": [
      "Left ventricular noncompaction cardiomyopathy"
    ],
    "gold_answer": "Noncompaction cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04731",
    "question": "What phenotype is associated with Pulmonary bullae causing pneumothorax?",
    "seeds": [
      "Pulmonary bullae causing pneumothorax"
    ],
    "gold_answer": "Repeated pneumothoraces",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04732",
    "question": "What phenotype is associated with Microcephaly-brain defect-spasticity-hypernatremia syndrome?",
    "seeds": [
      "Microcephaly-brain defect-spasticity-hypernatremia syndrome"
    ],
    "gold_answer": "Holoprosencephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04733",
    "question": "What is associated with Spermatogenic failure 49?",
    "seeds": [
      "Spermatogenic failure 49"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04734",
    "question": "What is associated with Decreased circulating ACTH concentration?",
    "seeds": [
      "Decreased circulating ACTH concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04735",
    "question": "What phenotype is associated with Glycogen storage disease Ic?",
    "seeds": [
      "Glycogen storage disease Ic"
    ],
    "gold_answer": "Hematuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04736",
    "question": "What is associated with Cutaneous mastocytosis-deafness-microtia syndrome?",
    "seeds": [
      "Cutaneous mastocytosis-deafness-microtia syndrome"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04737",
    "question": "What phenotype is associated with Plasminogen deficiency, type I?",
    "seeds": [
      "Plasminogen deficiency, type I"
    ],
    "gold_answer": "Macrocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04738",
    "question": "What is associated with Frontotemporal dementia and/or amyotrophic lateral sclerosis 6?",
    "seeds": [
      "Frontotemporal dementia and/or amyotrophic lateral sclerosis 6"
    ],
    "gold_answer": "NEFH",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_04739",
    "question": "What is associated with Disseminated cutaneous warts?",
    "seeds": [
      "Disseminated cutaneous warts"
    ],
    "gold_answer": "Papilloma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04740",
    "question": "What is associated with Complement component 4B deficiency?",
    "seeds": [
      "Complement component 4B deficiency"
    ],
    "gold_answer": "Pneumonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04741",
    "question": "What is associated with Familial episodic pain syndrome with predominantly upper body involvement?",
    "seeds": [
      "Familial episodic pain syndrome with predominantly upper body involvement"
    ],
    "gold_answer": "TRPA1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_train_04742",
    "question": "What is associated with Abnormal metabolic brain imaging by MRS?",
    "seeds": [
      "Abnormal metabolic brain imaging by MRS"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04743",
    "question": "What is associated with Isoniazid exposure?",
    "seeds": [
      "Isoniazid exposure"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04744",
    "question": "What is associated with Abnormality of the pulmonary artery?",
    "seeds": [
      "Abnormality of the pulmonary artery"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04745",
    "question": "What is associated with Renal atrophy?",
    "seeds": [
      "Renal atrophy"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04746",
    "question": "What is associated with Neoplasm of the peripheral nervous system?",
    "seeds": [
      "Neoplasm of the peripheral nervous system"
    ],
    "gold_answer": "Abnormal peripheral nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04747",
    "question": "What phenotype is associated with Cystic disease of lung?",
    "seeds": [
      "Cystic disease of lung"
    ],
    "gold_answer": "Spontaneous neonatal pneumothorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04748",
    "question": "What is associated with Refractory macrocytic anemia?",
    "seeds": [
      "Refractory macrocytic anemia"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04749",
    "question": "What is associated with Hypertrophic osteoarthropathy, primary, autosomal recessive 1?",
    "seeds": [
      "Hypertrophic osteoarthropathy, primary, autosomal recessive 1"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04750",
    "question": "What is associated with Positive fecal parasite test?",
    "seeds": [
      "Positive fecal parasite test"
    ],
    "gold_answer": "Abnormal stool composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04751",
    "question": "What is associated with Large radial epiphyses?",
    "seeds": [
      "Large radial epiphyses"
    ],
    "gold_answer": "Enlarged epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04752",
    "question": "What phenotype is associated with Cystic angiomatosis of bone, diffuse?",
    "seeds": [
      "Cystic angiomatosis of bone, diffuse"
    ],
    "gold_answer": "Cystic angiomatosis of bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04753",
    "question": "What is associated with Severe demyelination of the white matter?",
    "seeds": [
      "Severe demyelination of the white matter"
    ],
    "gold_answer": "CNS demyelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04754",
    "question": "What is associated with Congenital hypertrophy of retinal pigment epithelium?",
    "seeds": [
      "Congenital hypertrophy of retinal pigment epithelium"
    ],
    "gold_answer": "Abnormal fundus pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04755",
    "question": "What is associated with Extramedullary hematopoiesis?",
    "seeds": [
      "Extramedullary hematopoiesis"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04756",
    "question": "What phenotype is associated with Inflammatory bowel disease 11?",
    "seeds": [
      "Inflammatory bowel disease 11"
    ],
    "gold_answer": "Diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04757",
    "question": "What is associated with Malaligned philtral ridges?",
    "seeds": [
      "Malaligned philtral ridges"
    ],
    "gold_answer": "Abnormality of the philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04758",
    "question": "What is associated with Abnormality of uvular muscle?",
    "seeds": [
      "Abnormality of uvular muscle"
    ],
    "gold_answer": "Abnormality of musculature of soft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04759",
    "question": "What is associated with Increased urine harderoporphyrin level?",
    "seeds": [
      "Increased urine harderoporphyrin level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04760",
    "question": "What phenotype is associated with Tuberous sclerosis-2?",
    "seeds": [
      "Tuberous sclerosis-2"
    ],
    "gold_answer": "Ventriculomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04761",
    "question": "What phenotype is associated with Spondyloepimetaphyseal dysplasia, Krakow type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, Krakow type"
    ],
    "gold_answer": "Immunodeficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04762",
    "question": "What is associated with Hydronephrosis?",
    "seeds": [
      "Hydronephrosis"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04763",
    "question": "What is associated with Absent epiphysis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Absent epiphysis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Absent epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04764",
    "question": "What is associated with Elevated CSF 5-hydroxymethyluracil concentration?",
    "seeds": [
      "Elevated CSF 5-hydroxymethyluracil concentration"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04765",
    "question": "What is associated with Decreased CSF homovanillic acid concentration?",
    "seeds": [
      "Decreased CSF homovanillic acid concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04766",
    "question": "What is associated with Anti-H2A antibody positivity?",
    "seeds": [
      "Anti-H2A antibody positivity"
    ],
    "gold_answer": "Antinuclear antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04767",
    "question": "What is associated with Mesomelic dysplasia-digital anomalies-intellectual disability syndrome?",
    "seeds": [
      "Mesomelic dysplasia-digital anomalies-intellectual disability syndrome"
    ],
    "gold_answer": "AFF3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04768",
    "question": "What is associated with Vaginal myxoma?",
    "seeds": [
      "Vaginal myxoma"
    ],
    "gold_answer": "Vaginal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04769",
    "question": "What is associated with Orofacial dyskinesia?",
    "seeds": [
      "Orofacial dyskinesia"
    ],
    "gold_answer": "Dyskinesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04770",
    "question": "What is associated with Cockayne syndrome?",
    "seeds": [
      "Cockayne syndrome"
    ],
    "gold_answer": "Hypoplasia of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04771",
    "question": "What is associated with Vertical orbital dystopia?",
    "seeds": [
      "Vertical orbital dystopia"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04772",
    "question": "What is associated with Gemination?",
    "seeds": [
      "Gemination"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04773",
    "question": "What is associated with Short stature, microcephaly, and endocrine dysfunction?",
    "seeds": [
      "Short stature, microcephaly, and endocrine dysfunction"
    ],
    "gold_answer": "Aplasia/hypoplasia involving the skeleton",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04774",
    "question": "What is associated with Paraproteinemia?",
    "seeds": [
      "Paraproteinemia"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04775",
    "question": "What is associated with Dorsal forearm pain?",
    "seeds": [
      "Dorsal forearm pain"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04776",
    "question": "What is associated with Plaque-like facial hemangioma?",
    "seeds": [
      "Plaque-like facial hemangioma"
    ],
    "gold_answer": "Facial hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04777",
    "question": "What is associated with Decreased hepatic echogenicity?",
    "seeds": [
      "Decreased hepatic echogenicity"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04778",
    "question": "What is associated with Positive respiratory tract infectious agent test?",
    "seeds": [
      "Positive respiratory tract infectious agent test"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04779",
    "question": "What is associated with Bloodstream antifungal antibody positivity?",
    "seeds": [
      "Bloodstream antifungal antibody positivity"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04780",
    "question": "What is associated with Dorsal flexion contracture of the ankle?",
    "seeds": [
      "Dorsal flexion contracture of the ankle"
    ],
    "gold_answer": "Abnormality of the ankle",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04781",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 55?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 55"
    ],
    "gold_answer": "Absent speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04782",
    "question": "What is associated with Charcot-Marie-Tooth disease, X-linked recessive, 2?",
    "seeds": [
      "Charcot-Marie-Tooth disease, X-linked recessive, 2"
    ],
    "gold_answer": "Abnormal nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04783",
    "question": "What is associated with Fluctuance on palpation?",
    "seeds": [
      "Fluctuance on palpation"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04784",
    "question": "What is associated with Bent bone dysplasia syndrome 2?",
    "seeds": [
      "Bent bone dysplasia syndrome 2"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04785",
    "question": "What is associated with Progressive macrocephaly?",
    "seeds": [
      "Progressive macrocephaly"
    ],
    "gold_answer": "Macrocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04786",
    "question": "What phenotype is associated with Imperforate oropharynx-costovertebral anomalies syndrome?",
    "seeds": [
      "Imperforate oropharynx-costovertebral anomalies syndrome"
    ],
    "gold_answer": "Subglottic stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04787",
    "question": "What phenotype is associated with Coxoauricular syndrome?",
    "seeds": [
      "Coxoauricular syndrome"
    ],
    "gold_answer": "Abnormality of the urinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04788",
    "question": "What is associated with Leukoencephalopathy, progressive, infantile-onset, with or without deafness?",
    "seeds": [
      "Leukoencephalopathy, progressive, infantile-onset, with or without deafness"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04789",
    "question": "What is associated with Parotidomegaly, hereditary bilateral?",
    "seeds": [
      "Parotidomegaly, hereditary bilateral"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04790",
    "question": "What is associated with Abnormal liver enzyme activity or concentration?",
    "seeds": [
      "Abnormal liver enzyme activity or concentration"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04791",
    "question": "What is associated with Spurs of radial diaphysis?",
    "seeds": [
      "Spurs of radial diaphysis"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04792",
    "question": "What is associated with Roifman syndrome?",
    "seeds": [
      "Roifman syndrome"
    ],
    "gold_answer": "Abnormal ventricular septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04793",
    "question": "What is associated with Duplication of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Duplication of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal 2nd toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04794",
    "question": "What is associated with Mild postnatal growth retardation?",
    "seeds": [
      "Mild postnatal growth retardation"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04795",
    "question": "What is associated with Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete?",
    "seeds": [
      "Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete"
    ],
    "gold_answer": "Abnormality of adrenal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04796",
    "question": "What is associated with Osteochondral lesion of talus?",
    "seeds": [
      "Osteochondral lesion of talus"
    ],
    "gold_answer": "Abnormality of the tarsal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04797",
    "question": "What is associated with Enlarged epiphysis of the distal phalanx of the 5th toe?",
    "seeds": [
      "Enlarged epiphysis of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the distal phalanx of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04798",
    "question": "What is associated with Autosomal dominant neovascular inflammatory vitreoretinopathy?",
    "seeds": [
      "Autosomal dominant neovascular inflammatory vitreoretinopathy"
    ],
    "gold_answer": "CAPN5",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04799",
    "question": "What is associated with Arcuate artery intima/media arteriitis?",
    "seeds": [
      "Arcuate artery intima/media arteriitis"
    ],
    "gold_answer": "Abnormal intrarenal artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04800",
    "question": "What is associated with Decreased level of histidine-rich glycoprotein?",
    "seeds": [
      "Decreased level of histidine-rich glycoprotein"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04801",
    "question": "What is associated with Cytoplasmic antineutrophil antibody positivity?",
    "seeds": [
      "Cytoplasmic antineutrophil antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04802",
    "question": "What phenotype is associated with Isolated proximal femoral focal deficiency?",
    "seeds": [
      "Isolated proximal femoral focal deficiency"
    ],
    "gold_answer": "Aplasia/hypoplasia of the femur",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04803",
    "question": "What is associated with Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracicsomite anomalies?",
    "seeds": [
      "Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracicsomite anomalies"
    ],
    "gold_answer": "Increased blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04804",
    "question": "What phenotype is associated with Neutropenia, nonimmune chronic idiopathic, of adults?",
    "seeds": [
      "Neutropenia, nonimmune chronic idiopathic, of adults"
    ],
    "gold_answer": "Decreased total neutrophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04805",
    "question": "What is associated with Neoplasm?",
    "seeds": [
      "Neoplasm"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04806",
    "question": "What is associated with Focal cortical dysplasia type IIa?",
    "seeds": [
      "Focal cortical dysplasia type IIa"
    ],
    "gold_answer": "Cortical dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04807",
    "question": "What is associated with Triglyceride storage disease, type II?",
    "seeds": [
      "Triglyceride storage disease, type II"
    ],
    "gold_answer": "Increased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04808",
    "question": "What is associated with Spinocerebellar ataxia type 42?",
    "seeds": [
      "Spinocerebellar ataxia type 42"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04809",
    "question": "What is associated with Decreased maximal oxygen uptake?",
    "seeds": [
      "Decreased maximal oxygen uptake"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04810",
    "question": "What is associated with Vitreous haze?",
    "seeds": [
      "Vitreous haze"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04811",
    "question": "What phenotype is associated with Myotonia, potassium-aggravated?",
    "seeds": [
      "Myotonia, potassium-aggravated"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04812",
    "question": "What is associated with Abnormal B cell physiology?",
    "seeds": [
      "Abnormal B cell physiology"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04813",
    "question": "What is associated with Abnormal atrioventricular conduction?",
    "seeds": [
      "Abnormal atrioventricular conduction"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04814",
    "question": "What is associated with Pyriform aperture stenosis?",
    "seeds": [
      "Pyriform aperture stenosis"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04815",
    "question": "What is associated with Positive synovial fluid alpha-defensin?",
    "seeds": [
      "Positive synovial fluid alpha-defensin"
    ],
    "gold_answer": "Positive synonvial fluid infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04816",
    "question": "What is associated with Thyroid cancer, nonmedullary, 5?",
    "seeds": [
      "Thyroid cancer, nonmedullary, 5"
    ],
    "gold_answer": "Thyroid carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04817",
    "question": "What is associated with Abnormal muscle tissue enzyme activity or level?",
    "seeds": [
      "Abnormal muscle tissue enzyme activity or level"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04818",
    "question": "What is associated with Prolonged bleeding after surgery?",
    "seeds": [
      "Prolonged bleeding after surgery"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04819",
    "question": "What phenotype is associated with Leg, absence deformity of, with congenital cataract?",
    "seeds": [
      "Leg, absence deformity of, with congenital cataract"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04820",
    "question": "What is associated with Fatty streak?",
    "seeds": [
      "Fatty streak"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04821",
    "question": "What is associated with Pleuritic chest pain?",
    "seeds": [
      "Pleuritic chest pain"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04822",
    "question": "What is associated with Chronic monilial nail infection?",
    "seeds": [
      "Chronic monilial nail infection"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04823",
    "question": "What is associated with Ivory epiphysis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Ivory epiphysis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Sclerosis of finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04824",
    "question": "What is associated with Short syndrome?",
    "seeds": [
      "Short syndrome"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04825",
    "question": "What is associated with Cataract 1, multiple types?",
    "seeds": [
      "Cataract 1, multiple types"
    ],
    "gold_answer": "CRYBB1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04826",
    "question": "What is associated with Osteolytic defects of the middle phalanges of the hand?",
    "seeds": [
      "Osteolytic defects of the middle phalanges of the hand"
    ],
    "gold_answer": "Osteolysis involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04827",
    "question": "What is associated with 2nd-5th toe middle phalangeal hypoplasia?",
    "seeds": [
      "2nd-5th toe middle phalangeal hypoplasia"
    ],
    "gold_answer": "Short digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04828",
    "question": "What is associated with Diabetes insipidus, nephrogenic, 2?",
    "seeds": [
      "Diabetes insipidus, nephrogenic, 2"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04829",
    "question": "What phenotype is associated with Cataract 44?",
    "seeds": [
      "Cataract 44"
    ],
    "gold_answer": "Developmental cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04830",
    "question": "What is associated with Mitochondrial complex II deficiency?",
    "seeds": [
      "Mitochondrial complex II deficiency"
    ],
    "gold_answer": "MYBPC3",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "candidate_gene_tested_in"
    }
  },
  {
    "query_id": "orph_train_04831",
    "question": "What is associated with Ataxia-Oculomotor apraxia 3?",
    "seeds": [
      "Ataxia-Oculomotor apraxia 3"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04832",
    "question": "What is associated with Intercrural pterygium?",
    "seeds": [
      "Intercrural pterygium"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04833",
    "question": "What is associated with Almond-shaped palpebral fissure?",
    "seeds": [
      "Almond-shaped palpebral fissure"
    ],
    "gold_answer": "Abnormal shape of the palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04834",
    "question": "What is associated with Bronchial artery dilatation?",
    "seeds": [
      "Bronchial artery dilatation"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04835",
    "question": "What is associated with Epidermolysis bullosa simplex 1D, generalized, intermediate or severe, autosomal recessive?",
    "seeds": [
      "Epidermolysis bullosa simplex 1D, generalized, intermediate or severe, autosomal recessive"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04836",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 16?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 16"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04837",
    "question": "What is associated with Encephalopathy due to sulfite oxidase deficiency?",
    "seeds": [
      "Encephalopathy due to sulfite oxidase deficiency"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04838",
    "question": "What is associated with Duplication of the upper lip?",
    "seeds": [
      "Duplication of the upper lip"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04839",
    "question": "What is associated with Thyrotoxicosis from ectopic thyroid tissue?",
    "seeds": [
      "Thyrotoxicosis from ectopic thyroid tissue"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04840",
    "question": "What is associated with Hyperpigmented nodule?",
    "seeds": [
      "Hyperpigmented nodule"
    ],
    "gold_answer": "Skin nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04841",
    "question": "What is associated with Incyclophoria?",
    "seeds": [
      "Incyclophoria"
    ],
    "gold_answer": "Cyclodeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04842",
    "question": "What is associated with Reduced circulating 6-pyruvoyltetrahydropterin synthase activity?",
    "seeds": [
      "Reduced circulating 6-pyruvoyltetrahydropterin synthase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04843",
    "question": "What is associated with Dry hair?",
    "seeds": [
      "Dry hair"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04844",
    "question": "What is associated with Poorly formed metencephalon?",
    "seeds": [
      "Poorly formed metencephalon"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04845",
    "question": "What is associated with Retinal astrocytic hamartoma?",
    "seeds": [
      "Retinal astrocytic hamartoma"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04846",
    "question": "What is associated with Laryngeal cartilage malformation?",
    "seeds": [
      "Laryngeal cartilage malformation"
    ],
    "gold_answer": "Abnormal larynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04847",
    "question": "What is associated with Vascular hamartoma?",
    "seeds": [
      "Vascular hamartoma"
    ],
    "gold_answer": "Hamartoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04848",
    "question": "What is associated with Infantile liver failure syndrome 3?",
    "seeds": [
      "Infantile liver failure syndrome 3"
    ],
    "gold_answer": "Abnormal hip joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04849",
    "question": "What phenotype is associated with Bronchogenic cyst?",
    "seeds": [
      "Bronchogenic cyst"
    ],
    "gold_answer": "Neck pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04850",
    "question": "What is associated with Cerebroretinal microangiopathy with calcifications and cysts 1?",
    "seeds": [
      "Cerebroretinal microangiopathy with calcifications and cysts 1"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04851",
    "question": "What is associated with Ameliorated by ethanol ingestion?",
    "seeds": [
      "Ameliorated by ethanol ingestion"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04852",
    "question": "What phenotype is associated with Distichiasis with congenital anomalies of the heart and peripheral?",
    "seeds": [
      "Distichiasis with congenital anomalies of the heart and peripheral"
    ],
    "gold_answer": "Peripheral arterial stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04853",
    "question": "What is associated with Neurofacioskeletal syndrome with or without renal agenesis?",
    "seeds": [
      "Neurofacioskeletal syndrome with or without renal agenesis"
    ],
    "gold_answer": "Thin vermilion border",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04854",
    "question": "What is associated with Facial expressions not directed to others?",
    "seeds": [
      "Facial expressions not directed to others"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04855",
    "question": "What is associated with ZMYND11-related developmental delay-speech delay-seizures-behavioral abnormalities-craniofacial dysmorphism syndrome due to 10p15.3 microdeletion?",
    "seeds": [
      "ZMYND11-related developmental delay-speech delay-seizures-behavioral abnormalities-craniofacial dysmorphism syndrome due to 10p15.3 microdeletion"
    ],
    "gold_answer": "ZMYND11",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "role_in_the_phenotype_of"
    }
  },
  {
    "query_id": "orph_train_04856",
    "question": "What is associated with Impaired neutrophil chemotaxis?",
    "seeds": [
      "Impaired neutrophil chemotaxis"
    ],
    "gold_answer": "Reduction of neutrophil motility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04857",
    "question": "What is associated with X-linked dystonia-parkinsonism?",
    "seeds": [
      "X-linked dystonia-parkinsonism"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04858",
    "question": "What is associated with Hypovolemia?",
    "seeds": [
      "Hypovolemia"
    ],
    "gold_answer": "Abnormality of blood circulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04859",
    "question": "What phenotype is associated with GONADOBLASTOMA?",
    "seeds": [
      "GONADOBLASTOMA"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04860",
    "question": "What is associated with Congenital malformation of the great arteries?",
    "seeds": [
      "Congenital malformation of the great arteries"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04861",
    "question": "What is associated with Pili torti-onychodysplasia syndrome?",
    "seeds": [
      "Pili torti-onychodysplasia syndrome"
    ],
    "gold_answer": "Atypical scarring of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04862",
    "question": "What is associated with 4-5 finger cutaneous syndactyly?",
    "seeds": [
      "4-5 finger cutaneous syndactyly"
    ],
    "gold_answer": "Cutaneous finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04863",
    "question": "What phenotype is associated with Seborrhea-Like dermatitis with psoriasiform elements?",
    "seeds": [
      "Seborrhea-Like dermatitis with psoriasiform elements"
    ],
    "gold_answer": "Keratosis pilaris",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04864",
    "question": "What is associated with Cone-shaped epiphysis of the distal phalanx of the 5th finger?",
    "seeds": [
      "Cone-shaped epiphysis of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04865",
    "question": "What is associated with Dysbetalipoproteinemia?",
    "seeds": [
      "Dysbetalipoproteinemia"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04866",
    "question": "What is associated with Deafness, autosomal dominant 40?",
    "seeds": [
      "Deafness, autosomal dominant 40"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04867",
    "question": "What is associated with Long hallux?",
    "seeds": [
      "Long hallux"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04868",
    "question": "What is associated with Camptodactyly of finger?",
    "seeds": [
      "Camptodactyly of finger"
    ],
    "gold_answer": "Flexion contracture of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04869",
    "question": "What is associated with Absent axon flare response after intradermal histamine injection?",
    "seeds": [
      "Absent axon flare response after intradermal histamine injection"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04870",
    "question": "What is associated with Anemia, hypochromic microcytic, with iron overload 1?",
    "seeds": [
      "Anemia, hypochromic microcytic, with iron overload 1"
    ],
    "gold_answer": "Abnormal number of erythroid precursors",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04871",
    "question": "What is associated with Increased heart rate variability?",
    "seeds": [
      "Increased heart rate variability"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04872",
    "question": "What is associated with Craniometadiaphyseal dysplasia?",
    "seeds": [
      "Craniometadiaphyseal dysplasia"
    ],
    "gold_answer": "Increased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04873",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 43?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 43"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04874",
    "question": "What is associated with Short proximal phalanx of finger?",
    "seeds": [
      "Short proximal phalanx of finger"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04875",
    "question": "What is associated with Leukodystrophy?",
    "seeds": [
      "Leukodystrophy"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04876",
    "question": "What is associated with Costovertebral angle tenderness?",
    "seeds": [
      "Costovertebral angle tenderness"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04877",
    "question": "What phenotype is associated with Episodic pain syndrome, familial, 2?",
    "seeds": [
      "Episodic pain syndrome, familial, 2"
    ],
    "gold_answer": "Dysesthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04878",
    "question": "What is associated with Myelopathy?",
    "seeds": [
      "Myelopathy"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04879",
    "question": "What is associated with Tuberous xanthoma?",
    "seeds": [
      "Tuberous xanthoma"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04880",
    "question": "What phenotype is associated with Infantile Krabbe disease?",
    "seeds": [
      "Infantile Krabbe disease"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04881",
    "question": "What is associated with Cone-shaped epiphyses of the hallux?",
    "seeds": [
      "Cone-shaped epiphyses of the hallux"
    ],
    "gold_answer": "Abnormality of the epiphyses of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04882",
    "question": "What is associated with Increased level of 3-hydroxy-3-methylglutaric acid in urine?",
    "seeds": [
      "Increased level of 3-hydroxy-3-methylglutaric acid in urine"
    ],
    "gold_answer": "Abnormal urine carboxylic acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04883",
    "question": "What is associated with Reduced tissue aspartylglucosaminidase activity?",
    "seeds": [
      "Reduced tissue aspartylglucosaminidase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04884",
    "question": "What is associated with Spermatogenic failure 1?",
    "seeds": [
      "Spermatogenic failure 1"
    ],
    "gold_answer": "Infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04885",
    "question": "What is associated with Abnormality of lower eyelashes?",
    "seeds": [
      "Abnormality of lower eyelashes"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04886",
    "question": "What is associated with Nocturnal hypoventilation?",
    "seeds": [
      "Nocturnal hypoventilation"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04887",
    "question": "What is associated with Scleritis?",
    "seeds": [
      "Scleritis"
    ],
    "gold_answer": "Inflammatory abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04888",
    "question": "What is associated with Elevated urine 3-hydroxypropionic acid level?",
    "seeds": [
      "Elevated urine 3-hydroxypropionic acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04889",
    "question": "What phenotype is associated with Aromatase deficiency?",
    "seeds": [
      "Aromatase deficiency"
    ],
    "gold_answer": "Hepatic steatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04890",
    "question": "What phenotype is associated with Deafness, autosomal dominant 80?",
    "seeds": [
      "Deafness, autosomal dominant 80"
    ],
    "gold_answer": "Abnormal semicircular canal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04891",
    "question": "What is associated with Coloboma of choroid and retina?",
    "seeds": [
      "Coloboma of choroid and retina"
    ],
    "gold_answer": "ABCB6",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04892",
    "question": "What is associated with 1p36 deletion syndrome?",
    "seeds": [
      "1p36 deletion syndrome"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04893",
    "question": "What is associated with Abnormal breast physiology?",
    "seeds": [
      "Abnormal breast physiology"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04894",
    "question": "What is associated with Arcuate artery endoarterial foam cell hypercellularity?",
    "seeds": [
      "Arcuate artery endoarterial foam cell hypercellularity"
    ],
    "gold_answer": "Abnormal arcuate artery endothelium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04895",
    "question": "What is associated with Exposure to repetitive hand impact?",
    "seeds": [
      "Exposure to repetitive hand impact"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04896",
    "question": "What phenotype is associated with ACTH-independent macronodular adrenal hyperplasia 2?",
    "seeds": [
      "ACTH-independent macronodular adrenal hyperplasia 2"
    ],
    "gold_answer": "Hyperglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04897",
    "question": "What is associated with Rickets?",
    "seeds": [
      "Rickets"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04898",
    "question": "What is associated with Orthostatic hypotension?",
    "seeds": [
      "Orthostatic hypotension"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04899",
    "question": "What phenotype is associated with Felty syndrome?",
    "seeds": [
      "Felty syndrome"
    ],
    "gold_answer": "Peripheral neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04900",
    "question": "What is associated with Renal tubular epithelial cell swelling?",
    "seeds": [
      "Renal tubular epithelial cell swelling"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04901",
    "question": "What is associated with Osteogenesis imperfecta, type IX?",
    "seeds": [
      "Osteogenesis imperfecta, type IX"
    ],
    "gold_answer": "Abnormality of primary teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04902",
    "question": "What is associated with Small bowel atresia?",
    "seeds": [
      "Small bowel atresia"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04903",
    "question": "What is associated with Elevated vascular endothelial growth factor level?",
    "seeds": [
      "Elevated vascular endothelial growth factor level"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04904",
    "question": "What is associated with Broad nail?",
    "seeds": [
      "Broad nail"
    ],
    "gold_answer": "Nail dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04905",
    "question": "What is associated with Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies?",
    "seeds": [
      "Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04906",
    "question": "What is associated with Intellectual developmental disorder, X-linked 91?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 91"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04907",
    "question": "What is associated with Deafness, neurosensory, autosomal recessive 42?",
    "seeds": [
      "Deafness, neurosensory, autosomal recessive 42"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04908",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 12?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 12"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04909",
    "question": "What is associated with Reduced granulocyte CD16 level?",
    "seeds": [
      "Reduced granulocyte CD16 level"
    ],
    "gold_answer": "Abnormal flow cytometry test result",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04910",
    "question": "What is associated with Anti-phosphatidyl serine antibody positivity?",
    "seeds": [
      "Anti-phosphatidyl serine antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04911",
    "question": "What is associated with Abnormal peripheral nerve morphology by anatomical site?",
    "seeds": [
      "Abnormal peripheral nerve morphology by anatomical site"
    ],
    "gold_answer": "Abnormal peripheral nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04912",
    "question": "What is associated with Abnormal fetal pulmonary morphology?",
    "seeds": [
      "Abnormal fetal pulmonary morphology"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04913",
    "question": "What phenotype is associated with Primary ciliary dyskinesia?",
    "seeds": [
      "Primary ciliary dyskinesia"
    ],
    "gold_answer": "Conductive hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04914",
    "question": "What is associated with Stomatocytosis?",
    "seeds": [
      "Stomatocytosis"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04915",
    "question": "What is associated with Deafness, autosomal recessive 28?",
    "seeds": [
      "Deafness, autosomal recessive 28"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04916",
    "question": "What is associated with Increased total granulocyte count?",
    "seeds": [
      "Increased total granulocyte count"
    ],
    "gold_answer": "Abnormal leukocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04917",
    "question": "What is associated with Scaling skin on fingertip?",
    "seeds": [
      "Scaling skin on fingertip"
    ],
    "gold_answer": "Scaling skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04918",
    "question": "What is associated with Cervical spinal canal stenosis?",
    "seeds": [
      "Cervical spinal canal stenosis"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04919",
    "question": "What is associated with Deafness with labyrinthine aplasia, microtia, and microdontia?",
    "seeds": [
      "Deafness with labyrinthine aplasia, microtia, and microdontia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the external ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04920",
    "question": "What is associated with Flaujeac factor deficiency?",
    "seeds": [
      "Flaujeac factor deficiency"
    ],
    "gold_answer": "Abnormality of the intrinsic pathway",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04921",
    "question": "What is associated with Spondylitis?",
    "seeds": [
      "Spondylitis"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04922",
    "question": "What is associated with Chronic decreased circulating IgG2?",
    "seeds": [
      "Chronic decreased circulating IgG2"
    ],
    "gold_answer": "Decreased circulating IgG subclass concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04923",
    "question": "What is associated with Transitional cell carcinoma of the bladder?",
    "seeds": [
      "Transitional cell carcinoma of the bladder"
    ],
    "gold_answer": "Urinary tract neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04924",
    "question": "What phenotype is associated with Developmental delay, impaired speech, and behavioral abnormalities?",
    "seeds": [
      "Developmental delay, impaired speech, and behavioral abnormalities"
    ],
    "gold_answer": "Spinal neurofibromas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04925",
    "question": "What is associated with Arterial fibromuscular dysplasia?",
    "seeds": [
      "Arterial fibromuscular dysplasia"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04926",
    "question": "What is associated with Renal cortical adenoma?",
    "seeds": [
      "Renal cortical adenoma"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04927",
    "question": "What is associated with Porphyria, congenital erythropoietic?",
    "seeds": [
      "Porphyria, congenital erythropoietic"
    ],
    "gold_answer": "Abnormality of dental color",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04928",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 23?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 23"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04929",
    "question": "What is associated with Zimmermann-Laband syndrome 1?",
    "seeds": [
      "Zimmermann-Laband syndrome 1"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04930",
    "question": "What is associated with Focal emotional seizure with paranoia?",
    "seeds": [
      "Focal emotional seizure with paranoia"
    ],
    "gold_answer": "Non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04931",
    "question": "What is associated with Partial duplication of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Partial duplication of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Duplication of the distal phalanx of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04932",
    "question": "What is associated with Pseudoarthrosis?",
    "seeds": [
      "Pseudoarthrosis"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04933",
    "question": "What is associated with Anterior segment dysgenesis 5, multiple subtypes?",
    "seeds": [
      "Anterior segment dysgenesis 5, multiple subtypes"
    ],
    "gold_answer": "Abnormal anterior chamber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04934",
    "question": "What is associated with Abnormality of chromosome stability?",
    "seeds": [
      "Abnormality of chromosome stability"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04935",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 3?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 3"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04936",
    "question": "What is associated with Chordoma?",
    "seeds": [
      "Chordoma"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04937",
    "question": "What phenotype is associated with Lipoid congenital adrenal hyperplasia?",
    "seeds": [
      "Lipoid congenital adrenal hyperplasia"
    ],
    "gold_answer": "Hypospadias",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04938",
    "question": "What phenotype is associated with Monosomy 18q syndrome?",
    "seeds": [
      "Monosomy 18q syndrome"
    ],
    "gold_answer": "Myopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04939",
    "question": "What is associated with Accumulation of muscle fiber myotilin?",
    "seeds": [
      "Accumulation of muscle fiber myotilin"
    ],
    "gold_answer": "Abnormal muscle fiber myotilin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04940",
    "question": "What is associated with Increased blood pressure?",
    "seeds": [
      "Increased blood pressure"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04941",
    "question": "What is associated with Small epiphyses of the 3rd toe?",
    "seeds": [
      "Small epiphyses of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04942",
    "question": "What is associated with Angelman syndrome due to imprinting defect in 15q11-q13?",
    "seeds": [
      "Angelman syndrome due to imprinting defect in 15q11-q13"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04943",
    "question": "What is associated with Impaired vibratory sensation?",
    "seeds": [
      "Impaired vibratory sensation"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04944",
    "question": "What is associated with Mesomelic/rhizomelic limb shortening?",
    "seeds": [
      "Mesomelic/rhizomelic limb shortening"
    ],
    "gold_answer": "Rhizomelia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04945",
    "question": "What is associated with Neonatal short-limb short stature?",
    "seeds": [
      "Neonatal short-limb short stature"
    ],
    "gold_answer": "Disproportionate short-limb short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04946",
    "question": "What is associated with Gelatinous drop-like dystrophic cornea?",
    "seeds": [
      "Gelatinous drop-like dystrophic cornea"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04947",
    "question": "What is associated with Back pain?",
    "seeds": [
      "Back pain"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04948",
    "question": "What is associated with Complete duplication of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Complete duplication of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Duplication of phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04949",
    "question": "What is associated with Lactescent serum?",
    "seeds": [
      "Lactescent serum"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04950",
    "question": "What is associated with Diaphanospondylodysostosis?",
    "seeds": [
      "Diaphanospondylodysostosis"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04951",
    "question": "What is associated with Sensorimotor polyneuropathy affecting arms more than legs?",
    "seeds": [
      "Sensorimotor polyneuropathy affecting arms more than legs"
    ],
    "gold_answer": "Peripheral neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04952",
    "question": "What is associated with Eyelid myokymia?",
    "seeds": [
      "Eyelid myokymia"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04953",
    "question": "What is associated with Bone cyst?",
    "seeds": [
      "Bone cyst"
    ],
    "gold_answer": "Abnormal bone structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04954",
    "question": "What is associated with Hip dysplasia, Beukes type?",
    "seeds": [
      "Hip dysplasia, Beukes type"
    ],
    "gold_answer": "Wide femoral metaphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04955",
    "question": "What is associated with Delayed scintigraphic gallbladder filling?",
    "seeds": [
      "Delayed scintigraphic gallbladder filling"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04956",
    "question": "What is associated with Long foot?",
    "seeds": [
      "Long foot"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04957",
    "question": "What is associated with Postexertional symptom exacerbation?",
    "seeds": [
      "Postexertional symptom exacerbation"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04958",
    "question": "What is associated with Spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome?",
    "seeds": [
      "Spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04959",
    "question": "What is associated with Short middle phalanx of the 2nd finger?",
    "seeds": [
      "Short middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04960",
    "question": "What is associated with Sparse eyelashes?",
    "seeds": [
      "Sparse eyelashes"
    ],
    "gold_answer": "Sparse or absent eyelashes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04961",
    "question": "What is associated with Rete ridge flattening?",
    "seeds": [
      "Rete ridge flattening"
    ],
    "gold_answer": "Abnormal epidermal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04962",
    "question": "What is associated with Mitochondrial hypertrophy?",
    "seeds": [
      "Mitochondrial hypertrophy"
    ],
    "gold_answer": "Abnormality of the mitochondrion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04963",
    "question": "What is associated with Weak anal sphincter tone?",
    "seeds": [
      "Weak anal sphincter tone"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04964",
    "question": "What is associated with Finely dispersed lymph node lymphocyte chromatin?",
    "seeds": [
      "Finely dispersed lymph node lymphocyte chromatin"
    ],
    "gold_answer": "Abnormal lymph-node lymphoctye nuclear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04965",
    "question": "What is associated with Congenital disorder of deglycosylation 2?",
    "seeds": [
      "Congenital disorder of deglycosylation 2"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04966",
    "question": "What is associated with Cholestasis, intrahepatic, of pregnancy, 1?",
    "seeds": [
      "Cholestasis, intrahepatic, of pregnancy, 1"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04967",
    "question": "What is associated with Neurodevelopmental disorder with seizures and joint laxity?",
    "seeds": [
      "Neurodevelopmental disorder with seizures and joint laxity"
    ],
    "gold_answer": "Craniofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04968",
    "question": "What is associated with NFKB1-related immune dysregulation?",
    "seeds": [
      "NFKB1-related immune dysregulation"
    ],
    "gold_answer": "NFKB1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04969",
    "question": "What is associated with Torus palatinus?",
    "seeds": [
      "Torus palatinus"
    ],
    "gold_answer": "Abnormal hard palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04970",
    "question": "What is associated with Double inlet to single ventricle with two atrioventricular valves?",
    "seeds": [
      "Double inlet to single ventricle with two atrioventricular valves"
    ],
    "gold_answer": "Double inlet atrioventricular connection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04971",
    "question": "What is associated with Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome?",
    "seeds": [
      "Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04972",
    "question": "What is associated with Increased circulating interleukin 5 concentration?",
    "seeds": [
      "Increased circulating interleukin 5 concentration"
    ],
    "gold_answer": "Abnormal immune serum protein physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04973",
    "question": "What is associated with Nephrotic syndrome, type 6?",
    "seeds": [
      "Nephrotic syndrome, type 6"
    ],
    "gold_answer": "Abnormal circulating albumin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04974",
    "question": "What is associated with Cryptococcal meningitis?",
    "seeds": [
      "Cryptococcal meningitis"
    ],
    "gold_answer": "Meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04975",
    "question": "What is associated with Split-Hand/foot malformation 1?",
    "seeds": [
      "Split-Hand/foot malformation 1"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04976",
    "question": "What is associated with Purpura?",
    "seeds": [
      "Purpura"
    ],
    "gold_answer": "Subcutaneous hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04977",
    "question": "What is associated with Increased urinary mucus?",
    "seeds": [
      "Increased urinary mucus"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04978",
    "question": "What phenotype is associated with Brain-lung-thyroid syndrome?",
    "seeds": [
      "Brain-lung-thyroid syndrome"
    ],
    "gold_answer": "Cavum septum pellucidum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04979",
    "question": "What is associated with Reduced sympathoneural responses to the cold pressor test?",
    "seeds": [
      "Reduced sympathoneural responses to the cold pressor test"
    ],
    "gold_answer": "Abnormality of the autonomic nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04980",
    "question": "What is associated with Double inlet to single ventricle of indeterminate morphology?",
    "seeds": [
      "Double inlet to single ventricle of indeterminate morphology"
    ],
    "gold_answer": "Single ventricle",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04981",
    "question": "What is associated with Broad phalanges of the 4th finger?",
    "seeds": [
      "Broad phalanges of the 4th finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04982",
    "question": "What is associated with Autosomal dominant Charcot-Marie-Tooth disease type 2O?",
    "seeds": [
      "Autosomal dominant Charcot-Marie-Tooth disease type 2O"
    ],
    "gold_answer": "DYNC1H1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_04983",
    "question": "What phenotype is associated with Deafness, autosomal recessive 88?",
    "seeds": [
      "Deafness, autosomal recessive 88"
    ],
    "gold_answer": "Mixed hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04984",
    "question": "What is associated with Contracture of the distal interphalangeal joint of the 2nd toe?",
    "seeds": [
      "Contracture of the distal interphalangeal joint of the 2nd toe"
    ],
    "gold_answer": "Flexion contracture of digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04985",
    "question": "What is associated with Coxa magna?",
    "seeds": [
      "Coxa magna"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04986",
    "question": "What is associated with Flexion contracture of the 4th toe?",
    "seeds": [
      "Flexion contracture of the 4th toe"
    ],
    "gold_answer": "Flexion contracture of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04987",
    "question": "What is associated with Impulsivity?",
    "seeds": [
      "Impulsivity"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04988",
    "question": "What is associated with Abnormal CSF carboxylic acid concentration?",
    "seeds": [
      "Abnormal CSF carboxylic acid concentration"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04989",
    "question": "What is associated with Mesomelic dwarfism-cleft palate-camptodactyly syndrome?",
    "seeds": [
      "Mesomelic dwarfism-cleft palate-camptodactyly syndrome"
    ],
    "gold_answer": "Joint dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04990",
    "question": "What is associated with Abnormal circulating aldosterone concentration?",
    "seeds": [
      "Abnormal circulating aldosterone concentration"
    ],
    "gold_answer": "Abnormality of renin-angiotensin system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04991",
    "question": "What is associated with Abnormal circulating retinol-binding protein concentration?",
    "seeds": [
      "Abnormal circulating retinol-binding protein concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04992",
    "question": "What is associated with Anterior basal encephalocele?",
    "seeds": [
      "Anterior basal encephalocele"
    ],
    "gold_answer": "Open neural tube defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04993",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 26?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 26"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_04994",
    "question": "What is associated with Multinucleated giant chondrocytes in epiphyseal cartilage?",
    "seeds": [
      "Multinucleated giant chondrocytes in epiphyseal cartilage"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04995",
    "question": "What is associated with Alport syndrome?",
    "seeds": [
      "Alport syndrome"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04996",
    "question": "What is associated with Short columella?",
    "seeds": [
      "Short columella"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04997",
    "question": "What is associated with Iris hypoperfusion?",
    "seeds": [
      "Iris hypoperfusion"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04998",
    "question": "What is associated with Spermatogenic failure 39?",
    "seeds": [
      "Spermatogenic failure 39"
    ],
    "gold_answer": "Abnormal sperm physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_04999",
    "question": "What is associated with Mesangial cell loss?",
    "seeds": [
      "Mesangial cell loss"
    ],
    "gold_answer": "Abnormal glomerular mesangium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05000",
    "question": "What is associated with Vitreomacular adhesion?",
    "seeds": [
      "Vitreomacular adhesion"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05001",
    "question": "What is associated with Cortical radial artery intima/media liquefactive necrosis?",
    "seeds": [
      "Cortical radial artery intima/media liquefactive necrosis"
    ],
    "gold_answer": "Abnormal cortical radial artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05002",
    "question": "What is associated with Pain at the lateral aspect of the knee?",
    "seeds": [
      "Pain at the lateral aspect of the knee"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05003",
    "question": "What is associated with Abnormal CSF alpha-aminobutyrate concentration?",
    "seeds": [
      "Abnormal CSF alpha-aminobutyrate concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05004",
    "question": "What is associated with Radial bowing?",
    "seeds": [
      "Radial bowing"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05005",
    "question": "What is associated with Craniosynostosis 2?",
    "seeds": [
      "Craniosynostosis 2"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05006",
    "question": "What is associated with Comedonal acne?",
    "seeds": [
      "Comedonal acne"
    ],
    "gold_answer": "Acne",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05007",
    "question": "What phenotype is associated with Optic atrophy 3, autosomal dominant?",
    "seeds": [
      "Optic atrophy 3, autosomal dominant"
    ],
    "gold_answer": "Optic disc pallor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05008",
    "question": "What phenotype is associated with HEC syndrome?",
    "seeds": [
      "HEC syndrome"
    ],
    "gold_answer": "Congestive heart failure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05009",
    "question": "What is associated with Midline central nervous system lipomas?",
    "seeds": [
      "Midline central nervous system lipomas"
    ],
    "gold_answer": "Multiple central nervous system lipomas",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05010",
    "question": "What is associated with Translamellar aortic medial fibrosis?",
    "seeds": [
      "Translamellar aortic medial fibrosis"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05011",
    "question": "What is associated with Reduced granulocyte CD18 level?",
    "seeds": [
      "Reduced granulocyte CD18 level"
    ],
    "gold_answer": "Reduced cell surface marker level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05012",
    "question": "What is associated with Fractured proximal phalanx of digit 4?",
    "seeds": [
      "Fractured proximal phalanx of digit 4"
    ],
    "gold_answer": "Long-bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05013",
    "question": "What is associated with Abnormal circulating potassium concentration?",
    "seeds": [
      "Abnormal circulating potassium concentration"
    ],
    "gold_answer": "Abnormal blood ion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05014",
    "question": "What is associated with Impaired horizontal smooth pursuit?",
    "seeds": [
      "Impaired horizontal smooth pursuit"
    ],
    "gold_answer": "Abnormality of ocular smooth pursuit",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05015",
    "question": "What is associated with Macrocytic dyserythropoietic anemia?",
    "seeds": [
      "Macrocytic dyserythropoietic anemia"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05016",
    "question": "What is associated with Calciphylaxis?",
    "seeds": [
      "Calciphylaxis"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05017",
    "question": "What is associated with Complete atrioventricular septal defect?",
    "seeds": [
      "Complete atrioventricular septal defect"
    ],
    "gold_answer": "Cardiac conduction abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05018",
    "question": "What is associated with Autophagic vacuoles?",
    "seeds": [
      "Autophagic vacuoles"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05019",
    "question": "What phenotype is associated with Spermatogenic failure 11?",
    "seeds": [
      "Spermatogenic failure 11"
    ],
    "gold_answer": "Oligozoospermia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05020",
    "question": "What is associated with Dravet syndrome?",
    "seeds": [
      "Dravet syndrome"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05021",
    "question": "What is associated with Aortic aneurysm, familial thoracic 8?",
    "seeds": [
      "Aortic aneurysm, familial thoracic 8"
    ],
    "gold_answer": "Abnormal coronary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05022",
    "question": "What is associated with Pulmonary hyperplasia?",
    "seeds": [
      "Pulmonary hyperplasia"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05023",
    "question": "What is associated with Monilethrix 3?",
    "seeds": [
      "Monilethrix 3"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05024",
    "question": "What phenotype is associated with Nephrolithiasis, calcium oxalate?",
    "seeds": [
      "Nephrolithiasis, calcium oxalate"
    ],
    "gold_answer": "Acute kidney injury",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05025",
    "question": "What phenotype is associated with Spastic paraplegia 42, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 42, autosomal dominant"
    ],
    "gold_answer": "Spastic paraplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05026",
    "question": "What is associated with Subcortical localization?",
    "seeds": [
      "Subcortical localization"
    ],
    "gold_answer": "Brain localization",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05027",
    "question": "What is associated with Prolonged QTc interval?",
    "seeds": [
      "Prolonged QTc interval"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05028",
    "question": "What is associated with Intellectual developmental disorder with severe speech and ambulation defects?",
    "seeds": [
      "Intellectual developmental disorder with severe speech and ambulation defects"
    ],
    "gold_answer": "Epileptic spasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05029",
    "question": "What is associated with Abnormality of the spleen?",
    "seeds": [
      "Abnormality of the spleen"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05030",
    "question": "What is associated with Abnormal urine sebacic acid concentration?",
    "seeds": [
      "Abnormal urine sebacic acid concentration"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05031",
    "question": "What is associated with Portosystemic collateral veins?",
    "seeds": [
      "Portosystemic collateral veins"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05032",
    "question": "What is associated with Bracket epiphysis of the distal phalanx of the hallux?",
    "seeds": [
      "Bracket epiphysis of the distal phalanx of the hallux"
    ],
    "gold_answer": "Bracket epiphyses of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05033",
    "question": "What is associated with Intellectual developmental disorder with autism and speech delay?",
    "seeds": [
      "Intellectual developmental disorder with autism and speech delay"
    ],
    "gold_answer": "Autistic behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05034",
    "question": "What is associated with Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant?",
    "seeds": [
      "Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05035",
    "question": "What is associated with Acquired abnormal hair pattern?",
    "seeds": [
      "Acquired abnormal hair pattern"
    ],
    "gold_answer": "Abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05036",
    "question": "What is associated with Hordeolum externum?",
    "seeds": [
      "Hordeolum externum"
    ],
    "gold_answer": "Nodular changes affecting the eyelids",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05037",
    "question": "What is associated with Foveal photoreceptor outer segment loss on macular OCT?",
    "seeds": [
      "Foveal photoreceptor outer segment loss on macular OCT"
    ],
    "gold_answer": "Abnormal optical coherence tomography",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05038",
    "question": "What is associated with Mandibuloacral dysplasia progeroid syndrome?",
    "seeds": [
      "Mandibuloacral dysplasia progeroid syndrome"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05039",
    "question": "What is associated with Long QT syndrome 6?",
    "seeds": [
      "Long QT syndrome 6"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05040",
    "question": "What is associated with Paraganglioma?",
    "seeds": [
      "Paraganglioma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05041",
    "question": "What is associated with Epilepsy, progressive myoclonic, 12?",
    "seeds": [
      "Epilepsy, progressive myoclonic, 12"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05042",
    "question": "What is associated with Partial absence of foot?",
    "seeds": [
      "Partial absence of foot"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05043",
    "question": "What is associated with Calcification of the interosseus membrane of the forearm?",
    "seeds": [
      "Calcification of the interosseus membrane of the forearm"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05044",
    "question": "What is associated with Facial paresis, hereditary congenital, 2?",
    "seeds": [
      "Facial paresis, hereditary congenital, 2"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05045",
    "question": "What is associated with Intellectual developmental disorder, X-linked syndromic, Christianson type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic, Christianson type"
    ],
    "gold_answer": "Abnormal demeanor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05046",
    "question": "What is associated with Congenital blindness?",
    "seeds": [
      "Congenital blindness"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05047",
    "question": "What is associated with Panniculitis?",
    "seeds": [
      "Panniculitis"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05048",
    "question": "What is associated with 48,XXYY syndrome?",
    "seeds": [
      "48,XXYY syndrome"
    ],
    "gold_answer": "Abnormal esophagus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05049",
    "question": "What is associated with Spinocerebellar ataxia 11?",
    "seeds": [
      "Spinocerebellar ataxia 11"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05050",
    "question": "What is associated with Presence of uterus in 46,XY individual?",
    "seeds": [
      "Presence of uterus in 46,XY individual"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05051",
    "question": "What is associated with Benign prostatic hyperplasia?",
    "seeds": [
      "Benign prostatic hyperplasia"
    ],
    "gold_answer": "Abnormal prostate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05052",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 69?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 69"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05053",
    "question": "What phenotype is associated with Leopard syndrome 1?",
    "seeds": [
      "Leopard syndrome 1"
    ],
    "gold_answer": "Ureteral agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05054",
    "question": "What is associated with Limited extraocular movements?",
    "seeds": [
      "Limited extraocular movements"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05055",
    "question": "What is associated with Infantile liver failure syndrome 1?",
    "seeds": [
      "Infantile liver failure syndrome 1"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05056",
    "question": "What is associated with Advance sleep phase syndrome, familial, 4?",
    "seeds": [
      "Advance sleep phase syndrome, familial, 4"
    ],
    "gold_answer": "Sleep-wake cycle disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05057",
    "question": "What is associated with Pseudoepiphysis of the distal phalanx of the hallux?",
    "seeds": [
      "Pseudoepiphysis of the distal phalanx of the hallux"
    ],
    "gold_answer": "Pseudoepiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05058",
    "question": "What is associated with Aortic annulus calcification?",
    "seeds": [
      "Aortic annulus calcification"
    ],
    "gold_answer": "Cardiac valve calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05059",
    "question": "What is associated with Basal cell nevus syndrome 2?",
    "seeds": [
      "Basal cell nevus syndrome 2"
    ],
    "gold_answer": "Fibrous tissue neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05060",
    "question": "What is associated with Echolalia?",
    "seeds": [
      "Echolalia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05061",
    "question": "What phenotype is associated with Epidermolysis bullosa simplex, Weber-Cockayne type?",
    "seeds": [
      "Epidermolysis bullosa simplex, Weber-Cockayne type"
    ],
    "gold_answer": "Palmoplantar blistering",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05062",
    "question": "What is associated with Freeman-Sheldon syndrome?",
    "seeds": [
      "Freeman-Sheldon syndrome"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05063",
    "question": "What is associated with Developmental and epileptic encephalopathy 109?",
    "seeds": [
      "Developmental and epileptic encephalopathy 109"
    ],
    "gold_answer": "Generalized non-motor (absence) seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05064",
    "question": "What phenotype is associated with Thyroid hemiagenesis?",
    "seeds": [
      "Thyroid hemiagenesis"
    ],
    "gold_answer": "Thyroid adenoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05065",
    "question": "What is associated with Unilateral microphthalmos?",
    "seeds": [
      "Unilateral microphthalmos"
    ],
    "gold_answer": "Aplasia/Hypoplasia affecting the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05066",
    "question": "What is associated with Rigors?",
    "seeds": [
      "Rigors"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05067",
    "question": "What is associated with Abnormal fetal nasal bone visualization?",
    "seeds": [
      "Abnormal fetal nasal bone visualization"
    ],
    "gold_answer": "Abnormal fetal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05068",
    "question": "What is associated with 19p13.12 microdeletion syndrome?",
    "seeds": [
      "19p13.12 microdeletion syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05069",
    "question": "What is associated with Short iliac bones?",
    "seeds": [
      "Short iliac bones"
    ],
    "gold_answer": "Abnormal hip bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05070",
    "question": "What is associated with Polycystic kidney disease 6 with or without polycystic liver disease?",
    "seeds": [
      "Polycystic kidney disease 6 with or without polycystic liver disease"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05071",
    "question": "What is associated with Congenital abnormal hair pattern?",
    "seeds": [
      "Congenital abnormal hair pattern"
    ],
    "gold_answer": "Abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05072",
    "question": "What is associated with CD5 expression?",
    "seeds": [
      "CD5 expression"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05073",
    "question": "What is associated with Thrombocythemia 3?",
    "seeds": [
      "Thrombocythemia 3"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05074",
    "question": "What is associated with Aplasia/hypoplasia involving the skeleton?",
    "seeds": [
      "Aplasia/hypoplasia involving the skeleton"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05075",
    "question": "What is associated with Abdominal aortic aneurysm?",
    "seeds": [
      "Abdominal aortic aneurysm"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05076",
    "question": "What is associated with Glomerular proteinuria?",
    "seeds": [
      "Glomerular proteinuria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05077",
    "question": "What is associated with Inlet ventricular septal defect?",
    "seeds": [
      "Inlet ventricular septal defect"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05078",
    "question": "What is associated with Cataract 35?",
    "seeds": [
      "Cataract 35"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05079",
    "question": "What is associated with Patchy sclerosis of proximal phalanx of finger?",
    "seeds": [
      "Patchy sclerosis of proximal phalanx of finger"
    ],
    "gold_answer": "Sclerosis of proximal phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05080",
    "question": "What is associated with Limited hip extension?",
    "seeds": [
      "Limited hip extension"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05081",
    "question": "What is associated with Anti-tyrosine phosphatase region of islet antigen-2 antibody positivity?",
    "seeds": [
      "Anti-tyrosine phosphatase region of islet antigen-2 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05082",
    "question": "What phenotype is associated with Hypogonadotropic hypogonadism 20 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 20 with or without anosmia"
    ],
    "gold_answer": "Delayed puberty",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05083",
    "question": "What is associated with Abnormal number of teeth?",
    "seeds": [
      "Abnormal number of teeth"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05084",
    "question": "What is associated with Hyaloid vascular remnant and retrolental mass?",
    "seeds": [
      "Hyaloid vascular remnant and retrolental mass"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05085",
    "question": "What is associated with Hyperproteinemia?",
    "seeds": [
      "Hyperproteinemia"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05086",
    "question": "What is associated with Lower eyelid retraction?",
    "seeds": [
      "Lower eyelid retraction"
    ],
    "gold_answer": "Eyelid retraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05087",
    "question": "What is associated with Short distal phalanx of toe?",
    "seeds": [
      "Short distal phalanx of toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the distal phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05088",
    "question": "What is associated with Hemisacrum?",
    "seeds": [
      "Hemisacrum"
    ],
    "gold_answer": "Sacral segmentation defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05089",
    "question": "What is associated with Hydroureter?",
    "seeds": [
      "Hydroureter"
    ],
    "gold_answer": "Abnormal ureter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05090",
    "question": "What is associated with Abnormal horizontal rectus muscle physiology?",
    "seeds": [
      "Abnormal horizontal rectus muscle physiology"
    ],
    "gold_answer": "Abnormal rectus muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05091",
    "question": "What is associated with Decreased size of nerve terminals?",
    "seeds": [
      "Decreased size of nerve terminals"
    ],
    "gold_answer": "Abnormal peripheral nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05092",
    "question": "What is associated with Recent past medical history?",
    "seeds": [
      "Recent past medical history"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05093",
    "question": "What is associated with Abnormal tibia morphology?",
    "seeds": [
      "Abnormal tibia morphology"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05094",
    "question": "What is associated with Midline hand movements?",
    "seeds": [
      "Midline hand movements"
    ],
    "gold_answer": "Stereotypic upper-extremity movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05095",
    "question": "What is associated with Unesterified cholesterol accumulation in cultured fibroblasts?",
    "seeds": [
      "Unesterified cholesterol accumulation in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05096",
    "question": "What is associated with X-linked severe congenital neutropenia?",
    "seeds": [
      "X-linked severe congenital neutropenia"
    ],
    "gold_answer": "Abnormal total neutrophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05097",
    "question": "What is associated with Broad distal phalanx of the 4th finger?",
    "seeds": [
      "Broad distal phalanx of the 4th finger"
    ],
    "gold_answer": "Broad phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05098",
    "question": "What is associated with Head tremor?",
    "seeds": [
      "Head tremor"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05099",
    "question": "What phenotype is associated with Deafness, autosomal recessive 28?",
    "seeds": [
      "Deafness, autosomal recessive 28"
    ],
    "gold_answer": "Severe sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05100",
    "question": "What is associated with Central opacification of the cornea?",
    "seeds": [
      "Central opacification of the cornea"
    ],
    "gold_answer": "Opacification of the corneal stroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05101",
    "question": "What is associated with Enlarged metacarpal epiphyses?",
    "seeds": [
      "Enlarged metacarpal epiphyses"
    ],
    "gold_answer": "Abnormal metacarpal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05102",
    "question": "What is associated with Stippling of the epiphysis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Stippling of the epiphysis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the distal phalanx of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05103",
    "question": "What is associated with Intrahepatic bile duct dilatation?",
    "seeds": [
      "Intrahepatic bile duct dilatation"
    ],
    "gold_answer": "Abnormal intrahepatic bile duct morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05104",
    "question": "What is associated with Mitochondrial complex IV deficiency, nuclear type 15?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 15"
    ],
    "gold_answer": "Abnormal CSF lactate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05105",
    "question": "What is associated with Elevated urine octanoic acid level?",
    "seeds": [
      "Elevated urine octanoic acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05106",
    "question": "What is associated with Partial duplication of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Partial duplication of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal distal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05107",
    "question": "What is associated with Abnormality of salivation?",
    "seeds": [
      "Abnormality of salivation"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05108",
    "question": "What is associated with Impulsivity?",
    "seeds": [
      "Impulsivity"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05109",
    "question": "What is associated with Generalized aminoaciduria?",
    "seeds": [
      "Generalized aminoaciduria"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05110",
    "question": "What is associated with Paget disease of bone 6?",
    "seeds": [
      "Paget disease of bone 6"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05111",
    "question": "What is associated with COG8-CDG?",
    "seeds": [
      "COG8-CDG"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05112",
    "question": "What is associated with Foveal photoreceptor layer loss on macular OCT?",
    "seeds": [
      "Foveal photoreceptor layer loss on macular OCT"
    ],
    "gold_answer": "Abnormal retinal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05113",
    "question": "What is associated with Delayed speech and language development?",
    "seeds": [
      "Delayed speech and language development"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05114",
    "question": "What is associated with Widow's peak?",
    "seeds": [
      "Widow's peak"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05115",
    "question": "What is associated with Rahman syndrome?",
    "seeds": [
      "Rahman syndrome"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05116",
    "question": "What is associated with Arcuate vein lumen organized thrombi?",
    "seeds": [
      "Arcuate vein lumen organized thrombi"
    ],
    "gold_answer": "Abnormal arcuate vein lumen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05117",
    "question": "What is associated with Arcuate vein intimal mucoid edema?",
    "seeds": [
      "Arcuate vein intimal mucoid edema"
    ],
    "gold_answer": "Abnormal arcuate vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05118",
    "question": "What is associated with Placenta accreta?",
    "seeds": [
      "Placenta accreta"
    ],
    "gold_answer": "Abnormal placenta morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05119",
    "question": "What phenotype is associated with Renal hypoplasia, bilateral?",
    "seeds": [
      "Renal hypoplasia, bilateral"
    ],
    "gold_answer": "Glycosuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05120",
    "question": "What is associated with Irregular hyperpigmentation?",
    "seeds": [
      "Irregular hyperpigmentation"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05121",
    "question": "What is associated with Dysraphism-cleft lip/palate-limb reduction defects syndrome?",
    "seeds": [
      "Dysraphism-cleft lip/palate-limb reduction defects syndrome"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05122",
    "question": "What phenotype is associated with Parenteral nutrition-associated cholestasis?",
    "seeds": [
      "Parenteral nutrition-associated cholestasis"
    ],
    "gold_answer": "Elevated circulating hepatic transaminase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05123",
    "question": "What is associated with Granulocytic hyperplasia?",
    "seeds": [
      "Granulocytic hyperplasia"
    ],
    "gold_answer": "Abnormal granulocytopoietic cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05124",
    "question": "What is associated with Hippocampal sclerosis?",
    "seeds": [
      "Hippocampal sclerosis"
    ],
    "gold_answer": "Gliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05125",
    "question": "What is associated with Nutrition history?",
    "seeds": [
      "Nutrition history"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05126",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Sclerosis of proximal phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05127",
    "question": "What phenotype is associated with Robinow-Sorauf syndrome?",
    "seeds": [
      "Robinow-Sorauf syndrome"
    ],
    "gold_answer": "Pansynostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05128",
    "question": "What is associated with Abnormal CSF protein concentration?",
    "seeds": [
      "Abnormal CSF protein concentration"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05129",
    "question": "What phenotype is associated with Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2?",
    "seeds": [
      "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2"
    ],
    "gold_answer": "Cytochrome C oxidase-negative muscle fibers",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05130",
    "question": "What is associated with Molybdenum cofactor deficiency, type B2?",
    "seeds": [
      "Molybdenum cofactor deficiency, type B2"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05131",
    "question": "What is associated with Increased circulating T4 concentration?",
    "seeds": [
      "Increased circulating T4 concentration"
    ],
    "gold_answer": "Abnormal circulating thyroid hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05132",
    "question": "What is associated with Renal interstitial calcium phosphate deposits?",
    "seeds": [
      "Renal interstitial calcium phosphate deposits"
    ],
    "gold_answer": "Renal interstitial deposits",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05133",
    "question": "What is associated with Beta-alaninuria?",
    "seeds": [
      "Beta-alaninuria"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05134",
    "question": "What is associated with Irregular epiphysis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Irregular epiphysis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Irregular epiphyses of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05135",
    "question": "What is associated with Cigarette-paper scars?",
    "seeds": [
      "Cigarette-paper scars"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05136",
    "question": "What is associated with Intratubular calcium phosphate casts?",
    "seeds": [
      "Intratubular calcium phosphate casts"
    ],
    "gold_answer": "Renal intratubular casts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05137",
    "question": "What is associated with Postauricular pit?",
    "seeds": [
      "Postauricular pit"
    ],
    "gold_answer": "Periauricular skin pits",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05138",
    "question": "What is associated with Posterior vertebral body notching?",
    "seeds": [
      "Posterior vertebral body notching"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05139",
    "question": "What is associated with Increased urine phenylacetylglutamine level?",
    "seeds": [
      "Increased urine phenylacetylglutamine level"
    ],
    "gold_answer": "Increased urine proteinogenic amino acid derivative level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05140",
    "question": "What is associated with Elevated circulating reticulated platelet count?",
    "seeds": [
      "Elevated circulating reticulated platelet count"
    ],
    "gold_answer": "Abnormal platelet morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05141",
    "question": "What is associated with Decreased mixed venous oxygen saturation?",
    "seeds": [
      "Decreased mixed venous oxygen saturation"
    ],
    "gold_answer": "Abnormal mixed venous oxygen saturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05142",
    "question": "What is associated with Complete duplication of the first metacarpal?",
    "seeds": [
      "Complete duplication of the first metacarpal"
    ],
    "gold_answer": "Complete duplication of the proximal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05143",
    "question": "What is associated with Positive mycobacterium CSF microscopy?",
    "seeds": [
      "Positive mycobacterium CSF microscopy"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05144",
    "question": "What is associated with Ectodermal dysplasia 4, hair/nail type?",
    "seeds": [
      "Ectodermal dysplasia 4, hair/nail type"
    ],
    "gold_answer": "Abnormal eyelash morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05145",
    "question": "What is associated with Ulna metaphyseal dysplasia syndrome?",
    "seeds": [
      "Ulna metaphyseal dysplasia syndrome"
    ],
    "gold_answer": "Abnormal circulating calcium concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05146",
    "question": "What is associated with Periapical bone loss?",
    "seeds": [
      "Periapical bone loss"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05147",
    "question": "What is associated with Osteolytic defects of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Osteolytic defects of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Osteolytic defects of the phalanges of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05148",
    "question": "What is associated with Fixed head retroflexion?",
    "seeds": [
      "Fixed head retroflexion"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05149",
    "question": "What phenotype is associated with O'donnell-Luria-Rodan syndrome?",
    "seeds": [
      "O'donnell-Luria-Rodan syndrome"
    ],
    "gold_answer": "Abnormal corpus callosum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05150",
    "question": "What is associated with Hyperparathyroidism, transient neonatal?",
    "seeds": [
      "Hyperparathyroidism, transient neonatal"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05151",
    "question": "What is associated with Frontotemporal dementia and/or amyotrophic lateral sclerosis 4?",
    "seeds": [
      "Frontotemporal dementia and/or amyotrophic lateral sclerosis 4"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05152",
    "question": "What phenotype is associated with Chromosome 16p13.2 deletion syndrome?",
    "seeds": [
      "Chromosome 16p13.2 deletion syndrome"
    ],
    "gold_answer": "Premature adrenarche",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05153",
    "question": "What is associated with Abnormal anus morphology?",
    "seeds": [
      "Abnormal anus morphology"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05154",
    "question": "What is associated with Cortical radial artery intraluminal thrombi?",
    "seeds": [
      "Cortical radial artery intraluminal thrombi"
    ],
    "gold_answer": "Abnormal cortical radial artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05155",
    "question": "What is associated with Hip joint hypermobility?",
    "seeds": [
      "Hip joint hypermobility"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05156",
    "question": "What is associated with Synostosis involving bones of the upper limbs?",
    "seeds": [
      "Synostosis involving bones of the upper limbs"
    ],
    "gold_answer": "Abnormality of upper limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05157",
    "question": "What is associated with Non-caseating epithelioid cell granulomatosis?",
    "seeds": [
      "Non-caseating epithelioid cell granulomatosis"
    ],
    "gold_answer": "Abnormal macrophage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05158",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 59?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 59"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05159",
    "question": "What is associated with Abnormal leukocyte morphology?",
    "seeds": [
      "Abnormal leukocyte morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05160",
    "question": "What is associated with Microphthalmia, syndromic 13?",
    "seeds": [
      "Microphthalmia, syndromic 13"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05161",
    "question": "What is associated with Osteolytic defects of the proximal phalanx of the 3rd toe?",
    "seeds": [
      "Osteolytic defects of the proximal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal third toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05162",
    "question": "What is associated with Ovarian papillary adenocarcinoma?",
    "seeds": [
      "Ovarian papillary adenocarcinoma"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05163",
    "question": "What is associated with Asymmetric septal hypertrophy?",
    "seeds": [
      "Asymmetric septal hypertrophy"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05164",
    "question": "What is associated with Camptodactyly?",
    "seeds": [
      "Camptodactyly"
    ],
    "gold_answer": "Flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05165",
    "question": "What is associated with Enhanced neurotoxicity of vincristine?",
    "seeds": [
      "Enhanced neurotoxicity of vincristine"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05166",
    "question": "What is associated with MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome?",
    "seeds": [
      "MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome"
    ],
    "gold_answer": "Abnormal mitochondrial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05167",
    "question": "What is associated with Spermatogenic failure 52?",
    "seeds": [
      "Spermatogenic failure 52"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05168",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 2?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 2"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05169",
    "question": "What is associated with Aplasia/Hypoplasia of the 4th metacarpal?",
    "seeds": [
      "Aplasia/Hypoplasia of the 4th metacarpal"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05170",
    "question": "What is associated with Decreased circulating inhibin B concentration?",
    "seeds": [
      "Decreased circulating inhibin B concentration"
    ],
    "gold_answer": "Abnormal circulating inhibin B concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05171",
    "question": "What is associated with Anterior bowing of long bones?",
    "seeds": [
      "Anterior bowing of long bones"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05172",
    "question": "What phenotype is associated with Acrorenal-Mandibular syndrome?",
    "seeds": [
      "Acrorenal-Mandibular syndrome"
    ],
    "gold_answer": "Hypoplasia of the ulna",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05173",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 8?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 8"
    ],
    "gold_answer": "Abnormality of pancreas physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05174",
    "question": "What is associated with Distal lower limb amyotrophy?",
    "seeds": [
      "Distal lower limb amyotrophy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05175",
    "question": "What is associated with Autosomal dominant mitochondrial myopathy with exercise intolerance?",
    "seeds": [
      "Autosomal dominant mitochondrial myopathy with exercise intolerance"
    ],
    "gold_answer": "Abnormality of facial soft tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05176",
    "question": "What is associated with Partial duplication of the distal phalanx of the 4th finger?",
    "seeds": [
      "Partial duplication of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05177",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 50?",
    "seeds": [
      "Ciliary dyskinesia, primary, 50"
    ],
    "gold_answer": "Reduced sperm motility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05178",
    "question": "What is associated with Abnormal nail growth?",
    "seeds": [
      "Abnormal nail growth"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05179",
    "question": "What is associated with Epidermoid cyst?",
    "seeds": [
      "Epidermoid cyst"
    ],
    "gold_answer": "Cutaneous cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05180",
    "question": "What is associated with Oval macrocytosis?",
    "seeds": [
      "Oval macrocytosis"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05181",
    "question": "What is associated with Cerebellar ataxia-ectodermal dysplasia syndrome?",
    "seeds": [
      "Cerebellar ataxia-ectodermal dysplasia syndrome"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05182",
    "question": "What is associated with Cataract, crystalline coralliform?",
    "seeds": [
      "Cataract, crystalline coralliform"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05183",
    "question": "What is associated with Diamond-Blackfan anemia 21?",
    "seeds": [
      "Diamond-Blackfan anemia 21"
    ],
    "gold_answer": "Preaxial polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05184",
    "question": "What is associated with Hypodeviation?",
    "seeds": [
      "Hypodeviation"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05185",
    "question": "What is associated with Auditory sensory seeking?",
    "seeds": [
      "Auditory sensory seeking"
    ],
    "gold_answer": "Sensory seeking",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05186",
    "question": "What phenotype is associated with Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2?",
    "seeds": [
      "Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2"
    ],
    "gold_answer": "Leukoencephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05187",
    "question": "What is associated with Atrial tachyarrhythmia with short pr interval?",
    "seeds": [
      "Atrial tachyarrhythmia with short pr interval"
    ],
    "gold_answer": "Paroxysmal supraventricular tachycardia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05188",
    "question": "What is associated with Dysmorphic inferior cerebellar vermis?",
    "seeds": [
      "Dysmorphic inferior cerebellar vermis"
    ],
    "gold_answer": "Abnormal cerebellar vermis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05189",
    "question": "What is associated with Abnormal morphology of left ventricular trabeculae?",
    "seeds": [
      "Abnormal morphology of left ventricular trabeculae"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05190",
    "question": "What is associated with Adiposis dolorosa?",
    "seeds": [
      "Adiposis dolorosa"
    ],
    "gold_answer": "Abnormal oral physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05191",
    "question": "What is associated with DIASTEMATOMYELIA?",
    "seeds": [
      "DIASTEMATOMYELIA"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05192",
    "question": "What is associated with Lytic defects of ulnar metaphysis?",
    "seeds": [
      "Lytic defects of ulnar metaphysis"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05193",
    "question": "What is associated with Tubular shadows?",
    "seeds": [
      "Tubular shadows"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05194",
    "question": "What is associated with Spastic ataxia 9, autosomal recessive?",
    "seeds": [
      "Spastic ataxia 9, autosomal recessive"
    ],
    "gold_answer": "Functional motor deficit",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05195",
    "question": "What is associated with Reduced circulating complement concentration?",
    "seeds": [
      "Reduced circulating complement concentration"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05196",
    "question": "What is associated with Urate-Binding globulin, decrease in?",
    "seeds": [
      "Urate-Binding globulin, decrease in"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05197",
    "question": "What is associated with Metacarpophalangeal thumb joint contracture?",
    "seeds": [
      "Metacarpophalangeal thumb joint contracture"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05198",
    "question": "What is associated with Posterior-predominant lissencephaly-broad flat pons and medulla-midline crossing defects syndrome?",
    "seeds": [
      "Posterior-predominant lissencephaly-broad flat pons and medulla-midline crossing defects syndrome"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05199",
    "question": "What is associated with Pseudo-fractures?",
    "seeds": [
      "Pseudo-fractures"
    ],
    "gold_answer": "Abnormal cortical bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05200",
    "question": "What is associated with Abnormal geniohyoid muscle morphology?",
    "seeds": [
      "Abnormal geniohyoid muscle morphology"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05201",
    "question": "What is associated with Abnormal 5th metacarpal epiphysis morphology?",
    "seeds": [
      "Abnormal 5th metacarpal epiphysis morphology"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05202",
    "question": "What is associated with Prominent frontal sinuses?",
    "seeds": [
      "Prominent frontal sinuses"
    ],
    "gold_answer": "Abnormality of the upper respiratory tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05203",
    "question": "What is associated with Nodular subcortical heterotopia in peritrigonal regions?",
    "seeds": [
      "Nodular subcortical heterotopia in peritrigonal regions"
    ],
    "gold_answer": "Subcortical heterotopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05204",
    "question": "What phenotype is associated with Proteasome-associated autoinflammatory syndrome 6?",
    "seeds": [
      "Proteasome-associated autoinflammatory syndrome 6"
    ],
    "gold_answer": "Increased circulating interferon-gamma concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05205",
    "question": "What is associated with Abnormal retinal morphology on macular OCT?",
    "seeds": [
      "Abnormal retinal morphology on macular OCT"
    ],
    "gold_answer": "Abnormal posterior segment imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05206",
    "question": "What is associated with Macular cotton wool spot?",
    "seeds": [
      "Macular cotton wool spot"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05207",
    "question": "What is associated with Serpentine fibula?",
    "seeds": [
      "Serpentine fibula"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05208",
    "question": "What is associated with Intestinal perforation?",
    "seeds": [
      "Intestinal perforation"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05209",
    "question": "What is associated with Cranium bifidum occultum?",
    "seeds": [
      "Cranium bifidum occultum"
    ],
    "gold_answer": "Encephalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05210",
    "question": "What is associated with Hypnagogic hallucination?",
    "seeds": [
      "Hypnagogic hallucination"
    ],
    "gold_answer": "Sleep-wake transition abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05211",
    "question": "What is associated with Severe limb shortening?",
    "seeds": [
      "Severe limb shortening"
    ],
    "gold_answer": "Limb undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05212",
    "question": "What is associated with Charcot-Marie-Tooth disease type 4G?",
    "seeds": [
      "Charcot-Marie-Tooth disease type 4G"
    ],
    "gold_answer": "Talipes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05213",
    "question": "What is associated with Osteolytic defects of the middle phalanx of the 5th toe?",
    "seeds": [
      "Osteolytic defects of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Osteolytic defects of the phalanges of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05214",
    "question": "What is associated with Fetal subependymal hemorrhage?",
    "seeds": [
      "Fetal subependymal hemorrhage"
    ],
    "gold_answer": "Abnormal fetal central nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05215",
    "question": "What phenotype is associated with Parkinson disease 21?",
    "seeds": [
      "Parkinson disease 21"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05216",
    "question": "What is associated with Circumscribed palmoplantar hypokeratosis?",
    "seeds": [
      "Circumscribed palmoplantar hypokeratosis"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05217",
    "question": "What is associated with Lithium transport?",
    "seeds": [
      "Lithium transport"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05218",
    "question": "What is associated with Inspiratory crackles?",
    "seeds": [
      "Inspiratory crackles"
    ],
    "gold_answer": "Abnormal breath sound",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05219",
    "question": "What is associated with Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay?",
    "seeds": [
      "Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay"
    ],
    "gold_answer": "Sensory neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05220",
    "question": "What is associated with Second trimester onset?",
    "seeds": [
      "Second trimester onset"
    ],
    "gold_answer": "Fetal onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05221",
    "question": "What is associated with Ulnar radial head dislocation?",
    "seeds": [
      "Ulnar radial head dislocation"
    ],
    "gold_answer": "Dislocated radial head",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05222",
    "question": "What is associated with Neurocardiorenal malformation syndrome?",
    "seeds": [
      "Neurocardiorenal malformation syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05223",
    "question": "What is associated with Dystonia 25?",
    "seeds": [
      "Dystonia 25"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05224",
    "question": "What is associated with Limitation of neck motion?",
    "seeds": [
      "Limitation of neck motion"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05225",
    "question": "What is associated with Gingival bleeding?",
    "seeds": [
      "Gingival bleeding"
    ],
    "gold_answer": "Abnormality of the gingiva",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05226",
    "question": "What is associated with Maturity-onset diabetes of the young, type 12?",
    "seeds": [
      "Maturity-onset diabetes of the young, type 12"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05227",
    "question": "What is associated with Primrose syndrome?",
    "seeds": [
      "Primrose syndrome"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05228",
    "question": "What is associated with Osteoma of middle ear?",
    "seeds": [
      "Osteoma of middle ear"
    ],
    "gold_answer": "Neoplasm of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05229",
    "question": "What is associated with Coproporphyria?",
    "seeds": [
      "Coproporphyria"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05230",
    "question": "What is associated with Arcuate intimal/medial venulitis?",
    "seeds": [
      "Arcuate intimal/medial venulitis"
    ],
    "gold_answer": "Abnormal intrarenal vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05231",
    "question": "What is associated with Classical Ehlers-Danlos syndrome?",
    "seeds": [
      "Classical Ehlers-Danlos syndrome"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05232",
    "question": "What is associated with Hypertrichosis cubiti?",
    "seeds": [
      "Hypertrichosis cubiti"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05233",
    "question": "What is associated with Abnormal CSF phenylalanine concentration?",
    "seeds": [
      "Abnormal CSF phenylalanine concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05234",
    "question": "What is associated with Beckwith-Wiedemann syndrome due to imprinting defect of 11p15?",
    "seeds": [
      "Beckwith-Wiedemann syndrome due to imprinting defect of 11p15"
    ],
    "gold_answer": "H19",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "role_in_the_phenotype_of"
    }
  },
  {
    "query_id": "orph_train_05235",
    "question": "What is associated with Anterior ankle pain?",
    "seeds": [
      "Anterior ankle pain"
    ],
    "gold_answer": "Lower limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05236",
    "question": "What is associated with Middle cerebral artery stenosis?",
    "seeds": [
      "Middle cerebral artery stenosis"
    ],
    "gold_answer": "Abnormal cerebral artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05237",
    "question": "What is associated with Developmental and epileptic encephalopathy 47?",
    "seeds": [
      "Developmental and epileptic encephalopathy 47"
    ],
    "gold_answer": "Reduced attention regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05238",
    "question": "What phenotype is associated with Retinitis pigmentosa 20?",
    "seeds": [
      "Retinitis pigmentosa 20"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05239",
    "question": "What is associated with Abnormal psychotic pattern?",
    "seeds": [
      "Abnormal psychotic pattern"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05240",
    "question": "What is associated with Abnormal electroretinogram?",
    "seeds": [
      "Abnormal electroretinogram"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05241",
    "question": "What is associated with Osteochondroma?",
    "seeds": [
      "Osteochondroma"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05242",
    "question": "What is associated with Macroorchidism?",
    "seeds": [
      "Macroorchidism"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05243",
    "question": "What is associated with Immunodeficiency 94 with autoinflammation and dysmorphic facies?",
    "seeds": [
      "Immunodeficiency 94 with autoinflammation and dysmorphic facies"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05244",
    "question": "What is associated with Abnormality of the epiphyses of the 2nd finger?",
    "seeds": [
      "Abnormality of the epiphyses of the 2nd finger"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05245",
    "question": "What is associated with Neonatal Marfan syndrome?",
    "seeds": [
      "Neonatal Marfan syndrome"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05246",
    "question": "What phenotype is associated with Hypobetalipoproteinemia, familial, 2?",
    "seeds": [
      "Hypobetalipoproteinemia, familial, 2"
    ],
    "gold_answer": "Hypotriglyceridemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05247",
    "question": "What is associated with Deficit at segmental level?",
    "seeds": [
      "Deficit at segmental level"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05248",
    "question": "What is associated with Tooth malformation?",
    "seeds": [
      "Tooth malformation"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05249",
    "question": "What is associated with Hair follicle neoplasm?",
    "seeds": [
      "Hair follicle neoplasm"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05250",
    "question": "What is associated with Abnormal urinary purine level?",
    "seeds": [
      "Abnormal urinary purine level"
    ],
    "gold_answer": "Abnormal urinary nucleobase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05251",
    "question": "What is associated with Wide distal femoral metaphysis?",
    "seeds": [
      "Wide distal femoral metaphysis"
    ],
    "gold_answer": "Abnormal femoral metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05252",
    "question": "What is associated with Autosomal dominant congenital benign spinal muscular atrophy?",
    "seeds": [
      "Autosomal dominant congenital benign spinal muscular atrophy"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05253",
    "question": "What is associated with Abnormal circulating pyruvate family amino acid concentration?",
    "seeds": [
      "Abnormal circulating pyruvate family amino acid concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid derivative concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05254",
    "question": "What is associated with Gurrieri syndrome?",
    "seeds": [
      "Gurrieri syndrome"
    ],
    "gold_answer": "Abnormal iliac wing morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05255",
    "question": "What phenotype is associated with Complement component c1s deficiency?",
    "seeds": [
      "Complement component c1s deficiency"
    ],
    "gold_answer": "Raynaud phenomenon",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05256",
    "question": "What is associated with Myopathy, distal 3?",
    "seeds": [
      "Myopathy, distal 3"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05257",
    "question": "What phenotype is associated with Neurodegeneration, childhood-onset, with ataxia, tremor, optic atrophy, and cognitive decline?",
    "seeds": [
      "Neurodegeneration, childhood-onset, with ataxia, tremor, optic atrophy, and cognitive decline"
    ],
    "gold_answer": "Bowel incontinence",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05258",
    "question": "What is associated with Abnormal urinary nitrogen compound level?",
    "seeds": [
      "Abnormal urinary nitrogen compound level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05259",
    "question": "What is associated with Calcification of joints and arteries?",
    "seeds": [
      "Calcification of joints and arteries"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05260",
    "question": "What phenotype is associated with Microtia, third degree?",
    "seeds": [
      "Microtia, third degree"
    ],
    "gold_answer": "Macrotia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05261",
    "question": "What is associated with Abnormal vena cava physiology?",
    "seeds": [
      "Abnormal vena cava physiology"
    ],
    "gold_answer": "Abnormality of venous physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05262",
    "question": "What is associated with Positive nasopharyngeal corynebacterium diphtheriae nucleic acid test?",
    "seeds": [
      "Positive nasopharyngeal corynebacterium diphtheriae nucleic acid test"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05263",
    "question": "What is associated with Osteolytic defects of the phalanges of the 4th finger?",
    "seeds": [
      "Osteolytic defects of the phalanges of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05264",
    "question": "What is associated with KDM5C-related syndromic X-linked intellectual disability?",
    "seeds": [
      "KDM5C-related syndromic X-linked intellectual disability"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05265",
    "question": "What is associated with Nemaline myopathy 4?",
    "seeds": [
      "Nemaline myopathy 4"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05266",
    "question": "What is associated with Polyarticular chondrocalcinosis?",
    "seeds": [
      "Polyarticular chondrocalcinosis"
    ],
    "gold_answer": "Chondrocalcinosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05267",
    "question": "What is associated with Absent zona pellucida?",
    "seeds": [
      "Absent zona pellucida"
    ],
    "gold_answer": "Abnormal oocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05268",
    "question": "What is associated with Tracheal agenesis?",
    "seeds": [
      "Tracheal agenesis"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05269",
    "question": "What is associated with Fundic gland polyposis?",
    "seeds": [
      "Fundic gland polyposis"
    ],
    "gold_answer": "Neoplasm of the stomach",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05270",
    "question": "What is associated with FKRP-related limb-girdle muscular dystrophy R9?",
    "seeds": [
      "FKRP-related limb-girdle muscular dystrophy R9"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05271",
    "question": "What is associated with Near exotropia?",
    "seeds": [
      "Near exotropia"
    ],
    "gold_answer": "Exotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05272",
    "question": "What is associated with Optic atrophy 1?",
    "seeds": [
      "Optic atrophy 1"
    ],
    "gold_answer": "Color vision defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05273",
    "question": "What is associated with Arthrogryposis-Like hand anomaly and sensorineural deafness?",
    "seeds": [
      "Arthrogryposis-Like hand anomaly and sensorineural deafness"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05274",
    "question": "What is associated with Abnormality of the epiphysis of the middle phalanx of the 5th toe?",
    "seeds": [
      "Abnormality of the epiphysis of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05275",
    "question": "What is associated with Parietal hypometabolism in FDG PET?",
    "seeds": [
      "Parietal hypometabolism in FDG PET"
    ],
    "gold_answer": "Brain imaging abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05276",
    "question": "What is associated with Polyendocrine-polyneuropathy syndrome?",
    "seeds": [
      "Polyendocrine-polyneuropathy syndrome"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05277",
    "question": "What is associated with Progressive supranuclear palsy?",
    "seeds": [
      "Progressive supranuclear palsy"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05278",
    "question": "What is associated with EEG with frontal sharp waves?",
    "seeds": [
      "EEG with frontal sharp waves"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05279",
    "question": "What is associated with Enteric anendocrinosis?",
    "seeds": [
      "Enteric anendocrinosis"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05280",
    "question": "What is associated with Irregular RR interval?",
    "seeds": [
      "Irregular RR interval"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05281",
    "question": "What is associated with Pancreatic colipase deficiency?",
    "seeds": [
      "Pancreatic colipase deficiency"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05282",
    "question": "What is associated with Radio-Tartaglia syndrome?",
    "seeds": [
      "Radio-Tartaglia syndrome"
    ],
    "gold_answer": "Abnormal fetal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05283",
    "question": "What is associated with Posterior embryotoxon?",
    "seeds": [
      "Posterior embryotoxon"
    ],
    "gold_answer": "Abnormal line of Schwalbe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05284",
    "question": "What is associated with Spinal myoclonus?",
    "seeds": [
      "Spinal myoclonus"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05285",
    "question": "What is associated with Bruising susceptibility?",
    "seeds": [
      "Bruising susceptibility"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05286",
    "question": "What is associated with Slanting of the palpebral fissure?",
    "seeds": [
      "Slanting of the palpebral fissure"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05287",
    "question": "What is associated with Cartilaginous ossification of larynx?",
    "seeds": [
      "Cartilaginous ossification of larynx"
    ],
    "gold_answer": "Abnormality of the larynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05288",
    "question": "What is associated with Complete duplication of proximal phalanx of the thumb?",
    "seeds": [
      "Complete duplication of proximal phalanx of the thumb"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05289",
    "question": "What is associated with Absent zona pellucida?",
    "seeds": [
      "Absent zona pellucida"
    ],
    "gold_answer": "Abnormal zona pellucida morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05290",
    "question": "What is associated with Reduced factor VII activity?",
    "seeds": [
      "Reduced factor VII activity"
    ],
    "gold_answer": "Abnormality of the extrinsic pathway",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05291",
    "question": "What is associated with Hyperammonemia due to N-acetylglutamate synthase deficiency?",
    "seeds": [
      "Hyperammonemia due to N-acetylglutamate synthase deficiency"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05292",
    "question": "What is associated with Left ventricular thrombus?",
    "seeds": [
      "Left ventricular thrombus"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05293",
    "question": "What is associated with Granulomatosis with polyangiitis?",
    "seeds": [
      "Granulomatosis with polyangiitis"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05294",
    "question": "What phenotype is associated with Glutathione peroxidase deficiency?",
    "seeds": [
      "Glutathione peroxidase deficiency"
    ],
    "gold_answer": "Compensated hemolytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05295",
    "question": "What is associated with Lupus erythematosus tumidus?",
    "seeds": [
      "Lupus erythematosus tumidus"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05296",
    "question": "What is associated with Dopamine antagonist exposure?",
    "seeds": [
      "Dopamine antagonist exposure"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05297",
    "question": "What is associated with Craniocervical junction constriction?",
    "seeds": [
      "Craniocervical junction constriction"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05298",
    "question": "What is associated with Hawkinsinuria?",
    "seeds": [
      "Hawkinsinuria"
    ],
    "gold_answer": "Dicarboxylic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05299",
    "question": "What is associated with Abnormal class-switched memory B cell proportion?",
    "seeds": [
      "Abnormal class-switched memory B cell proportion"
    ],
    "gold_answer": "Abnormal B cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05300",
    "question": "What is associated with Focal cognitive seizure with forced thinking?",
    "seeds": [
      "Focal cognitive seizure with forced thinking"
    ],
    "gold_answer": "Psychic epileptic aura",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05301",
    "question": "What is associated with Elevated urinary 2,4-dihydroxybutyric acid level?",
    "seeds": [
      "Elevated urinary 2,4-dihydroxybutyric acid level"
    ],
    "gold_answer": "Organic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05302",
    "question": "What is associated with Broad phalanx?",
    "seeds": [
      "Broad phalanx"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05303",
    "question": "What phenotype is associated with Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia?",
    "seeds": [
      "Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia"
    ],
    "gold_answer": "Lewy bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05304",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 39?",
    "seeds": [
      "Ciliary dyskinesia, primary, 39"
    ],
    "gold_answer": "Tachypnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05305",
    "question": "What is associated with Uric acid urolithiasis independent of gout?",
    "seeds": [
      "Uric acid urolithiasis independent of gout"
    ],
    "gold_answer": "Uric acid nephrolithiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05306",
    "question": "What is associated with Kleefstra syndrome 2?",
    "seeds": [
      "Kleefstra syndrome 2"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05307",
    "question": "What is associated with Neuromuscular dysphagia?",
    "seeds": [
      "Neuromuscular dysphagia"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05308",
    "question": "What is associated with Hypoplastic pulmonary veins?",
    "seeds": [
      "Hypoplastic pulmonary veins"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05309",
    "question": "What phenotype is associated with Temtamy syndrome?",
    "seeds": [
      "Temtamy syndrome"
    ],
    "gold_answer": "Convex nasal ridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05310",
    "question": "What is associated with Food intolerance?",
    "seeds": [
      "Food intolerance"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05311",
    "question": "What is associated with Neuropathy, hereditary sensory and autonomic, type II?",
    "seeds": [
      "Neuropathy, hereditary sensory and autonomic, type II"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05312",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 37?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 37"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05313",
    "question": "What is associated with Congenital horizontal nystagmus?",
    "seeds": [
      "Congenital horizontal nystagmus"
    ],
    "gold_answer": "Congenital nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05314",
    "question": "What is associated with Reduced tissue argininosuccinate synthetase activity?",
    "seeds": [
      "Reduced tissue argininosuccinate synthetase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05315",
    "question": "What is associated with Difficulty floating in water?",
    "seeds": [
      "Difficulty floating in water"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05316",
    "question": "What is associated with Multinodular goiter?",
    "seeds": [
      "Multinodular goiter"
    ],
    "gold_answer": "Abnormal thyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05317",
    "question": "What phenotype is associated with ALACRIMA?",
    "seeds": [
      "ALACRIMA"
    ],
    "gold_answer": "Punctate corneal epithelial erosions",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05318",
    "question": "What is associated with Exudative vitreoretinopathy 8?",
    "seeds": [
      "Exudative vitreoretinopathy 8"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05319",
    "question": "What is associated with Abnormally low-pitched voice?",
    "seeds": [
      "Abnormally low-pitched voice"
    ],
    "gold_answer": "Abnormal prosody",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05320",
    "question": "What is associated with Abnormality of adrenal physiology?",
    "seeds": [
      "Abnormality of adrenal physiology"
    ],
    "gold_answer": "Abnormality of the adrenal glands",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05321",
    "question": "What is associated with Focal myositis?",
    "seeds": [
      "Focal myositis"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05322",
    "question": "What is associated with Non-syndromic agammaglobulinemia?",
    "seeds": [
      "Non-syndromic agammaglobulinemia"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05323",
    "question": "What is associated with Transient decreased circulating IgE concentration?",
    "seeds": [
      "Transient decreased circulating IgE concentration"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05324",
    "question": "What is associated with Elevated CSF beta-alanine concentration?",
    "seeds": [
      "Elevated CSF beta-alanine concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05325",
    "question": "What is associated with Hereditary angioedema type 1?",
    "seeds": [
      "Hereditary angioedema type 1"
    ],
    "gold_answer": "Abnormal pharynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05326",
    "question": "What is associated with Generalized arterial tortuosity?",
    "seeds": [
      "Generalized arterial tortuosity"
    ],
    "gold_answer": "Arterial tortuosity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05327",
    "question": "What phenotype is associated with Tuberous sclerosis-2?",
    "seeds": [
      "Tuberous sclerosis-2"
    ],
    "gold_answer": "Ventriculomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05328",
    "question": "What is associated with Wide space between 4th and 5th toe?",
    "seeds": [
      "Wide space between 4th and 5th toe"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05329",
    "question": "What is associated with Scoliosis, isolated, susceptibility to, 6?",
    "seeds": [
      "Scoliosis, isolated, susceptibility to, 6"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05330",
    "question": "What is associated with Abnormality of the premaxilla?",
    "seeds": [
      "Abnormality of the premaxilla"
    ],
    "gold_answer": "Abnormal maxilla morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05331",
    "question": "What phenotype is associated with Li-Takada-Miyake syndrome?",
    "seeds": [
      "Li-Takada-Miyake syndrome"
    ],
    "gold_answer": "Enuresis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05332",
    "question": "What is associated with Intellectual disability-myopathy-short stature-endocrine defect syndrome?",
    "seeds": [
      "Intellectual disability-myopathy-short stature-endocrine defect syndrome"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05333",
    "question": "What is associated with Xanthogranulomatous pyelonephritis?",
    "seeds": [
      "Xanthogranulomatous pyelonephritis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05334",
    "question": "What is associated with Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies?",
    "seeds": [
      "Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05335",
    "question": "What is associated with Skin plaque?",
    "seeds": [
      "Skin plaque"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05336",
    "question": "What is associated with Reduced insulin-like factor 3 level?",
    "seeds": [
      "Reduced insulin-like factor 3 level"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05337",
    "question": "What phenotype is associated with Immunodeficiency 62?",
    "seeds": [
      "Immunodeficiency 62"
    ],
    "gold_answer": "Autoimmune thrombocytopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05338",
    "question": "What is associated with Bullet-shaped proximal toe phalanx?",
    "seeds": [
      "Bullet-shaped proximal toe phalanx"
    ],
    "gold_answer": "Bullet-shaped toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05339",
    "question": "What is associated with Coarctation in the transverse aortic arch?",
    "seeds": [
      "Coarctation in the transverse aortic arch"
    ],
    "gold_answer": "Hypoplastic ventricle",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05340",
    "question": "What is associated with Short stature with nonspecific skeletal abnormalities?",
    "seeds": [
      "Short stature with nonspecific skeletal abnormalities"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05341",
    "question": "What is associated with Postductal coarctation of the aorta?",
    "seeds": [
      "Postductal coarctation of the aorta"
    ],
    "gold_answer": "Abnormal aortic arch morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05342",
    "question": "What phenotype is associated with Corneal dystrophy, fuchs endothelial, 1?",
    "seeds": [
      "Corneal dystrophy, fuchs endothelial, 1"
    ],
    "gold_answer": "Corneal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05343",
    "question": "What is associated with Ciliary dyskinesia, primary, 18?",
    "seeds": [
      "Ciliary dyskinesia, primary, 18"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05344",
    "question": "What is associated with Renal arteriole intima/media liquefactive necrosis?",
    "seeds": [
      "Renal arteriole intima/media liquefactive necrosis"
    ],
    "gold_answer": "Abnormal renal arteriole morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05345",
    "question": "What is associated with Recurrent protozoan infections?",
    "seeds": [
      "Recurrent protozoan infections"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05346",
    "question": "What is associated with Distal sensory impairment of all modalities?",
    "seeds": [
      "Distal sensory impairment of all modalities"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05347",
    "question": "What is associated with Aplasia/Hypoplasia of the 3rd finger?",
    "seeds": [
      "Aplasia/Hypoplasia of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05348",
    "question": "What is associated with Addictive cocaine use?",
    "seeds": [
      "Addictive cocaine use"
    ],
    "gold_answer": "Addictive substance use",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05349",
    "question": "What is associated with Spinocerebellar ataxia, X-linked 2?",
    "seeds": [
      "Spinocerebellar ataxia, X-linked 2"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05350",
    "question": "What phenotype is associated with Mitochondrial complex I deficiency, nuclear type 10?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 10"
    ],
    "gold_answer": "Dysphagia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05351",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanx of the hallux?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal hallux phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05352",
    "question": "What is associated with Abnormal anterior fontanelle morphology?",
    "seeds": [
      "Abnormal anterior fontanelle morphology"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05353",
    "question": "What is associated with Ameliorated by colchicine?",
    "seeds": [
      "Ameliorated by colchicine"
    ],
    "gold_answer": "Ameliorated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05354",
    "question": "What is associated with Abnormal circulating gastrin concentration?",
    "seeds": [
      "Abnormal circulating gastrin concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05355",
    "question": "What phenotype is associated with Dystonia 22, adult-onset?",
    "seeds": [
      "Dystonia 22, adult-onset"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05356",
    "question": "What is associated with Abnormality of palatoglossus muscle?",
    "seeds": [
      "Abnormality of palatoglossus muscle"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05357",
    "question": "What is associated with Anti-P/Q-type VGCC antibody positivity?",
    "seeds": [
      "Anti-P/Q-type VGCC antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05358",
    "question": "What is associated with Follicular hyperkeratosis?",
    "seeds": [
      "Follicular hyperkeratosis"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05359",
    "question": "What is associated with Oral cavity telangiectasia?",
    "seeds": [
      "Oral cavity telangiectasia"
    ],
    "gold_answer": "Telangiectasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05360",
    "question": "What phenotype is associated with Deafness, autosomal dominant 65?",
    "seeds": [
      "Deafness, autosomal dominant 65"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05361",
    "question": "What is associated with Euthyroid hyperthyroxinemia?",
    "seeds": [
      "Euthyroid hyperthyroxinemia"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05362",
    "question": "What is associated with Delusions of infestation?",
    "seeds": [
      "Delusions of infestation"
    ],
    "gold_answer": "Delusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05363",
    "question": "What is associated with Pontocerebellar hypoplasia, type 14?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 14"
    ],
    "gold_answer": "Abnormal cortical gyration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05364",
    "question": "What is associated with Shortened outer dynein arms?",
    "seeds": [
      "Shortened outer dynein arms"
    ],
    "gold_answer": "Abnormal respiratory motile cilium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05365",
    "question": "What phenotype is associated with Undifferentiated connective tissue syndrome?",
    "seeds": [
      "Undifferentiated connective tissue syndrome"
    ],
    "gold_answer": "Anti-ribosome Po antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05366",
    "question": "What is associated with Erythrokeratodermia variabilis?",
    "seeds": [
      "Erythrokeratodermia variabilis"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05367",
    "question": "What phenotype is associated with Intellectual disability syndrome due to a DYRK1A point mutation?",
    "seeds": [
      "Intellectual disability syndrome due to a DYRK1A point mutation"
    ],
    "gold_answer": "Autistic behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05368",
    "question": "What is associated with Asymmetric thickening of the nipple-areolar complex?",
    "seeds": [
      "Asymmetric thickening of the nipple-areolar complex"
    ],
    "gold_answer": "Abnormality of the breast",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05369",
    "question": "What is associated with Facial diplegia?",
    "seeds": [
      "Facial diplegia"
    ],
    "gold_answer": "Facial palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05370",
    "question": "What is associated with Dent disease type 2?",
    "seeds": [
      "Dent disease type 2"
    ],
    "gold_answer": "OCRL",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_05371",
    "question": "What is associated with Hypoplasia of the vagina?",
    "seeds": [
      "Hypoplasia of the vagina"
    ],
    "gold_answer": "Abnormal vagina morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05372",
    "question": "What is associated with Carnitine palmitoyl transferase II deficiency, myopathic form?",
    "seeds": [
      "Carnitine palmitoyl transferase II deficiency, myopathic form"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05373",
    "question": "What is associated with Hypertrichosis lanuginosa congenita?",
    "seeds": [
      "Hypertrichosis lanuginosa congenita"
    ],
    "gold_answer": "Abnormality of the gingiva",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05374",
    "question": "What phenotype is associated with Spastic paraplegia 44, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 44, autosomal recessive"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05375",
    "question": "What is associated with Viral encephalitis?",
    "seeds": [
      "Viral encephalitis"
    ],
    "gold_answer": "Severe infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05376",
    "question": "What is associated with Posterior rib cupping?",
    "seeds": [
      "Posterior rib cupping"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05377",
    "question": "What is associated with Elevated imprint of the transverse sinuses?",
    "seeds": [
      "Elevated imprint of the transverse sinuses"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05378",
    "question": "What is associated with Optic pit?",
    "seeds": [
      "Optic pit"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05379",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 116?",
    "seeds": [
      "Developmental and epileptic encephalopathy 116"
    ],
    "gold_answer": "CNS hypomyelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05380",
    "question": "What is associated with Abnormal sex determination?",
    "seeds": [
      "Abnormal sex determination"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05381",
    "question": "What is associated with Right sided atrium to left ventricle and absent left sided atrioventricular connection?",
    "seeds": [
      "Right sided atrium to left ventricle and absent left sided atrioventricular connection"
    ],
    "gold_answer": "Abnormal connection of the cardiac segments",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05382",
    "question": "What is associated with Abnormality of the ureter?",
    "seeds": [
      "Abnormality of the ureter"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05383",
    "question": "What is associated with Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth?",
    "seeds": [
      "Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05384",
    "question": "What is associated with Sparse lower eyelashes?",
    "seeds": [
      "Sparse lower eyelashes"
    ],
    "gold_answer": "Sparse or absent eyelashes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05385",
    "question": "What is associated with Paraplegia?",
    "seeds": [
      "Paraplegia"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05386",
    "question": "What phenotype is associated with 2p15p16.1 microdeletion syndrome?",
    "seeds": [
      "2p15p16.1 microdeletion syndrome"
    ],
    "gold_answer": "Prominent nasal tip",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05387",
    "question": "What phenotype is associated with Hypobetalipoproteinemia, familial, 1?",
    "seeds": [
      "Hypobetalipoproteinemia, familial, 1"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05388",
    "question": "What is associated with Sepsis?",
    "seeds": [
      "Sepsis"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05389",
    "question": "What is associated with Branchiootic syndrome 3?",
    "seeds": [
      "Branchiootic syndrome 3"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05390",
    "question": "What phenotype is associated with Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay?",
    "seeds": [
      "Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay"
    ],
    "gold_answer": "Insomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05391",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 18?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 18"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05392",
    "question": "What is associated with Colon perforation?",
    "seeds": [
      "Colon perforation"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05393",
    "question": "What is associated with Eczematoid dermatitis?",
    "seeds": [
      "Eczematoid dermatitis"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05394",
    "question": "What is associated with Abnormal amplitude of dark-adapted dim flash electroretinogram?",
    "seeds": [
      "Abnormal amplitude of dark-adapted dim flash electroretinogram"
    ],
    "gold_answer": "Abnormal dark-adapted dim flash electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05395",
    "question": "What is associated with Hereditary angioedema with normal C1Inh?",
    "seeds": [
      "Hereditary angioedema with normal C1Inh"
    ],
    "gold_answer": "Abnormality of complement system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05396",
    "question": "What is associated with Hypoplastic fifth toenail?",
    "seeds": [
      "Hypoplastic fifth toenail"
    ],
    "gold_answer": "Hypoplastic toenails",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05397",
    "question": "What phenotype is associated with Rhabdomyolysis, susceptibility to, 1?",
    "seeds": [
      "Rhabdomyolysis, susceptibility to, 1"
    ],
    "gold_answer": "Rhabdomyolysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05398",
    "question": "What is associated with Prolonged bleeding following circumcision?",
    "seeds": [
      "Prolonged bleeding following circumcision"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05399",
    "question": "What phenotype is associated with Hemoglobin-Delta locus?",
    "seeds": [
      "Hemoglobin-Delta locus"
    ],
    "gold_answer": "Imbalanced hemoglobin synthesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05400",
    "question": "What is associated with Hereditary pheochromocytoma-paraganglioma?",
    "seeds": [
      "Hereditary pheochromocytoma-paraganglioma"
    ],
    "gold_answer": "Abnormality of chorioretinal pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05401",
    "question": "What is associated with Spinocerebellar tract degeneration?",
    "seeds": [
      "Spinocerebellar tract degeneration"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05402",
    "question": "What is associated with Abnormal circulating chemokine concentration?",
    "seeds": [
      "Abnormal circulating chemokine concentration"
    ],
    "gold_answer": "Abnormal immune serum protein physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05403",
    "question": "What is associated with Abnormal circulating thromboxane concentration?",
    "seeds": [
      "Abnormal circulating thromboxane concentration"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05404",
    "question": "What is associated with Seizures, benign familial infantile, 5?",
    "seeds": [
      "Seizures, benign familial infantile, 5"
    ],
    "gold_answer": "Dialeptic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05405",
    "question": "What is associated with Abnormal sperm head morphology?",
    "seeds": [
      "Abnormal sperm head morphology"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05406",
    "question": "What is associated with Upper extremity joint dislocation?",
    "seeds": [
      "Upper extremity joint dislocation"
    ],
    "gold_answer": "Joint dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05407",
    "question": "What is associated with Right ventricular thrombus?",
    "seeds": [
      "Right ventricular thrombus"
    ],
    "gold_answer": "Abnormal right ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05408",
    "question": "What phenotype is associated with Hyperphosphatasia with impaired intellectual development syndrome 1?",
    "seeds": [
      "Hyperphosphatasia with impaired intellectual development syndrome 1"
    ],
    "gold_answer": "Wide nasal bridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05409",
    "question": "What is associated with Nephropathy?",
    "seeds": [
      "Nephropathy"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05410",
    "question": "What is associated with Diffuse cerebral sclerosis?",
    "seeds": [
      "Diffuse cerebral sclerosis"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05411",
    "question": "What is associated with Positive fecal Clostridium botulinum test?",
    "seeds": [
      "Positive fecal Clostridium botulinum test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05412",
    "question": "What phenotype is associated with Triokinase and FMN cyclase deficiency syndrome?",
    "seeds": [
      "Triokinase and FMN cyclase deficiency syndrome"
    ],
    "gold_answer": "Pancreatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05413",
    "question": "What is associated with Monoclonal elevation of IgG?",
    "seeds": [
      "Monoclonal elevation of IgG"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05414",
    "question": "What is associated with Abnormality of hair texture?",
    "seeds": [
      "Abnormality of hair texture"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05415",
    "question": "What is associated with Lymphatic malformation 14?",
    "seeds": [
      "Lymphatic malformation 14"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05416",
    "question": "What phenotype is associated with Usher syndrome, type IC?",
    "seeds": [
      "Usher syndrome, type IC"
    ],
    "gold_answer": "Vestibular hyporeflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05417",
    "question": "What is associated with Aortic arch aneurysm?",
    "seeds": [
      "Aortic arch aneurysm"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05418",
    "question": "What is associated with Congenital malformation of the right heart?",
    "seeds": [
      "Congenital malformation of the right heart"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05419",
    "question": "What is associated with Deafness, autosomal recessive 29?",
    "seeds": [
      "Deafness, autosomal recessive 29"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05420",
    "question": "What phenotype is associated with Spastic paraplegia 14, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 14, autosomal recessive"
    ],
    "gold_answer": "Pes cavus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05421",
    "question": "What is associated with Aplasia/Hypoplasia involving the nose?",
    "seeds": [
      "Aplasia/Hypoplasia involving the nose"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05422",
    "question": "What is associated with Increased glucose-6-phosphate dehydrogenase level in blood?",
    "seeds": [
      "Increased glucose-6-phosphate dehydrogenase level in blood"
    ],
    "gold_answer": "Abnormal circulating glucose-6-phosphate dehydrogenase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05423",
    "question": "What is associated with Corpus callosum, agenesis of?",
    "seeds": [
      "Corpus callosum, agenesis of"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05424",
    "question": "What is associated with Generalized clonic seizure?",
    "seeds": [
      "Generalized clonic seizure"
    ],
    "gold_answer": "Generalized-onset motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05425",
    "question": "What is associated with Partial duplication of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Partial duplication of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal morphology of the proximal phalanx of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05426",
    "question": "What is associated with Cardiofaciocutaneous syndrome 3?",
    "seeds": [
      "Cardiofaciocutaneous syndrome 3"
    ],
    "gold_answer": "Abnormality of temperature regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05427",
    "question": "What is associated with Low maternal circulating estriol concentration?",
    "seeds": [
      "Low maternal circulating estriol concentration"
    ],
    "gold_answer": "Abnormal maternal serum screening",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05428",
    "question": "What phenotype is associated with Nasopharyngeal carcinoma, susceptibility to, 3?",
    "seeds": [
      "Nasopharyngeal carcinoma, susceptibility to, 3"
    ],
    "gold_answer": "Neoplasia of the nasopharynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05429",
    "question": "What is associated with Hypogonadotropic hypogonadism 21 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 21 with or without anosmia"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05430",
    "question": "What is associated with Meningocele?",
    "seeds": [
      "Meningocele"
    ],
    "gold_answer": "Neural tube defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05431",
    "question": "What is associated with Kariminejad neurodevelopmental syndrome?",
    "seeds": [
      "Kariminejad neurodevelopmental syndrome"
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05432",
    "question": "What is associated with Decreased response to growth hormone stimulation test?",
    "seeds": [
      "Decreased response to growth hormone stimulation test"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05433",
    "question": "What phenotype is associated with Braddock syndrome?",
    "seeds": [
      "Braddock syndrome"
    ],
    "gold_answer": "Blepharophimosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05434",
    "question": "What is associated with Anti-arbovirus antibody positivity?",
    "seeds": [
      "Anti-arbovirus antibody positivity"
    ],
    "gold_answer": "Bloodstream virus-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05435",
    "question": "What is associated with Vascular compression of the eighth cranial nerve?",
    "seeds": [
      "Vascular compression of the eighth cranial nerve"
    ],
    "gold_answer": "Abnormal vestibulocochlear nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05436",
    "question": "What is associated with Abnormal erythrocyte metabolite concentration?",
    "seeds": [
      "Abnormal erythrocyte metabolite concentration"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05437",
    "question": "What is associated with Triggered by fava bean ingestion?",
    "seeds": [
      "Triggered by fava bean ingestion"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05438",
    "question": "What is associated with Stapes ankylosis?",
    "seeds": [
      "Stapes ankylosis"
    ],
    "gold_answer": "Abnormality of the middle ear ossicles",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05439",
    "question": "What is associated with Scleral schwannoma?",
    "seeds": [
      "Scleral schwannoma"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05440",
    "question": "What is associated with Primary immunodeficiency syndrome due to P14/LAMTOR2 deficiency?",
    "seeds": [
      "Primary immunodeficiency syndrome due to P14/LAMTOR2 deficiency"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05441",
    "question": "What is associated with Postcoital vaginal bleeding?",
    "seeds": [
      "Postcoital vaginal bleeding"
    ],
    "gold_answer": "Abnormal vaginal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05442",
    "question": "What is associated with Rh deficiency syndrome?",
    "seeds": [
      "Rh deficiency syndrome"
    ],
    "gold_answer": "Abnormal circulating bilirubin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05443",
    "question": "What is associated with Ectopic gallstone?",
    "seeds": [
      "Ectopic gallstone"
    ],
    "gold_answer": "Abnormality of the gallbladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05444",
    "question": "What is associated with Recurrent fractures?",
    "seeds": [
      "Recurrent fractures"
    ],
    "gold_answer": "Increased susceptibility to fractures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05445",
    "question": "What is associated with Heterozygous beta-thalassemia intermedia with supernumerary alpha-globin gene?",
    "seeds": [
      "Heterozygous beta-thalassemia intermedia with supernumerary alpha-globin gene"
    ],
    "gold_answer": "HBA2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "role_in_the_phenotype_of"
    }
  },
  {
    "query_id": "orph_train_05446",
    "question": "What phenotype is associated with Hypomagnesemia 7, renal, with or without dilated cardiomyopathy?",
    "seeds": [
      "Hypomagnesemia 7, renal, with or without dilated cardiomyopathy"
    ],
    "gold_answer": "Reduced left ventricular ejection fraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05447",
    "question": "What is associated with Absent middle phalanx of 5th finger?",
    "seeds": [
      "Absent middle phalanx of 5th finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05448",
    "question": "What is associated with Proprioceptive-induced seizure?",
    "seeds": [
      "Proprioceptive-induced seizure"
    ],
    "gold_answer": "Reflex seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05449",
    "question": "What is associated with Clavicular pseudarthrosis?",
    "seeds": [
      "Clavicular pseudarthrosis"
    ],
    "gold_answer": "Abnormal clavicle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05450",
    "question": "What phenotype is associated with TOOTH SIZE?",
    "seeds": [
      "TOOTH SIZE"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05451",
    "question": "What is associated with Dilatation of celiac artery?",
    "seeds": [
      "Dilatation of celiac artery"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05452",
    "question": "What is associated with Aplasia of posterior communicating artery?",
    "seeds": [
      "Aplasia of posterior communicating artery"
    ],
    "gold_answer": "Abnormal posterior circulating artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05453",
    "question": "What is associated with Flaring of rib cage?",
    "seeds": [
      "Flaring of rib cage"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05454",
    "question": "What is associated with Amelogenesis imperfecta?",
    "seeds": [
      "Amelogenesis imperfecta"
    ],
    "gold_answer": "Abnormal dental enamel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05455",
    "question": "What phenotype is associated with X-linked spastic paraplegia type 34?",
    "seeds": [
      "X-linked spastic paraplegia type 34"
    ],
    "gold_answer": "Impaired vibration sensation in the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05456",
    "question": "What is associated with Neurodevelopmental disorder and language delay with or without structural brain abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder and language delay with or without structural brain abnormalities"
    ],
    "gold_answer": "Non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05457",
    "question": "What is associated with Transposition of the great arteries, dextro-looped 1?",
    "seeds": [
      "Transposition of the great arteries, dextro-looped 1"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05458",
    "question": "What is associated with Thin clavicles?",
    "seeds": [
      "Thin clavicles"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05459",
    "question": "What is associated with Helix syndrome?",
    "seeds": [
      "Helix syndrome"
    ],
    "gold_answer": "Abnormality of the parathyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05460",
    "question": "What is associated with Transient hyperphenylalaninemia?",
    "seeds": [
      "Transient hyperphenylalaninemia"
    ],
    "gold_answer": "Abnormal circulating phenylalanine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05461",
    "question": "What is associated with Severe growth deficiency-strabismus-extensive dermal melanocytosis-intellectual disability syndrome?",
    "seeds": [
      "Severe growth deficiency-strabismus-extensive dermal melanocytosis-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05462",
    "question": "What phenotype is associated with 8q21.11 microdeletion syndrome?",
    "seeds": [
      "8q21.11 microdeletion syndrome"
    ],
    "gold_answer": "Microphthalmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05463",
    "question": "What phenotype is associated with Hepatitis, fulminant viral, susceptibility to?",
    "seeds": [
      "Hepatitis, fulminant viral, susceptibility to"
    ],
    "gold_answer": "Fatigue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05464",
    "question": "What is associated with Susceptibility to coronavirus 229e?",
    "seeds": [
      "Susceptibility to coronavirus 229e"
    ],
    "gold_answer": "Recurrent viral infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05465",
    "question": "What is associated with Hyperbeta-alaninemia?",
    "seeds": [
      "Hyperbeta-alaninemia"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05466",
    "question": "What is associated with Contracture of the distal interphalangeal joint of the fingers?",
    "seeds": [
      "Contracture of the distal interphalangeal joint of the fingers"
    ],
    "gold_answer": "Finger joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05467",
    "question": "What is associated with Impaired tandem gait?",
    "seeds": [
      "Impaired tandem gait"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05468",
    "question": "What is associated with Kahrizi syndrome?",
    "seeds": [
      "Kahrizi syndrome"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05469",
    "question": "What is associated with Congenital vertical talus, unilateral?",
    "seeds": [
      "Congenital vertical talus, unilateral"
    ],
    "gold_answer": "HOXD10",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_05470",
    "question": "What is associated with Caesarean section?",
    "seeds": [
      "Caesarean section"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05471",
    "question": "What phenotype is associated with Atrial fibrillation, familial, 2?",
    "seeds": [
      "Atrial fibrillation, familial, 2"
    ],
    "gold_answer": "Atrial fibrillation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05472",
    "question": "What is associated with Inflammation of the large intestine?",
    "seeds": [
      "Inflammation of the large intestine"
    ],
    "gold_answer": "Gastrointestinal inflammation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05473",
    "question": "What is associated with Decreased pituitary glycoprotein hormone alpha subunit level?",
    "seeds": [
      "Decreased pituitary glycoprotein hormone alpha subunit level"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05474",
    "question": "What phenotype is associated with MYT1L-related developmental delay-intellectual disability-obesity syndrome?",
    "seeds": [
      "MYT1L-related developmental delay-intellectual disability-obesity syndrome"
    ],
    "gold_answer": "Maternal diabetes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05475",
    "question": "What is associated with Methylmalonic aciduria and homocystinuria, Cblj type?",
    "seeds": [
      "Methylmalonic aciduria and homocystinuria, Cblj type"
    ],
    "gold_answer": "Abnormal cardiac atrium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05476",
    "question": "What is associated with Increased muscle fatiguability?",
    "seeds": [
      "Increased muscle fatiguability"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05477",
    "question": "What is associated with Anti-NR2A antibody positivity?",
    "seeds": [
      "Anti-NR2A antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05478",
    "question": "What is associated with Obesity?",
    "seeds": [
      "Obesity"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05479",
    "question": "What is associated with Sandal gap?",
    "seeds": [
      "Sandal gap"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05480",
    "question": "What is associated with Microcephaly 8, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 8, primary, autosomal recessive"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05481",
    "question": "What is associated with Coloboma?",
    "seeds": [
      "Coloboma"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05482",
    "question": "What is associated with Hypotrichosis and recurrent skin vesicles?",
    "seeds": [
      "Hypotrichosis and recurrent skin vesicles"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05483",
    "question": "What phenotype is associated with Fetal akinesia deformation sequence 3?",
    "seeds": [
      "Fetal akinesia deformation sequence 3"
    ],
    "gold_answer": "Short neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05484",
    "question": "What is associated with Radiculomegaly?",
    "seeds": [
      "Radiculomegaly"
    ],
    "gold_answer": "Abnormal dental root morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05485",
    "question": "What is associated with Lactescent serum?",
    "seeds": [
      "Lactescent serum"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05486",
    "question": "What phenotype is associated with Sertoli cell-only syndrome?",
    "seeds": [
      "Sertoli cell-only syndrome"
    ],
    "gold_answer": "Sertoli cell-only phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05487",
    "question": "What is associated with 9q31.1q31.3 microdeletion syndrome?",
    "seeds": [
      "9q31.1q31.3 microdeletion syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05488",
    "question": "What is associated with Nuclear cataract?",
    "seeds": [
      "Nuclear cataract"
    ],
    "gold_answer": "Zonular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05489",
    "question": "What is associated with Mitochondrial complex II deficiency, nuclear type 4?",
    "seeds": [
      "Mitochondrial complex II deficiency, nuclear type 4"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05490",
    "question": "What is associated with Addictive methylphenidate use?",
    "seeds": [
      "Addictive methylphenidate use"
    ],
    "gold_answer": "Addictive stimulant use",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05491",
    "question": "What is associated with Diminished circulating hyaluronidase activity?",
    "seeds": [
      "Diminished circulating hyaluronidase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05492",
    "question": "What is associated with Schnitzler syndrome?",
    "seeds": [
      "Schnitzler syndrome"
    ],
    "gold_answer": "Hematological neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05493",
    "question": "What is associated with Toe phalanx fracture?",
    "seeds": [
      "Toe phalanx fracture"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05494",
    "question": "What phenotype is associated with Spermatogenic failure, X-linked, 7?",
    "seeds": [
      "Spermatogenic failure, X-linked, 7"
    ],
    "gold_answer": "Multiflagellar spermatozoa",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05495",
    "question": "What is associated with Insulin-Like growth factor I deficiency?",
    "seeds": [
      "Insulin-Like growth factor I deficiency"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05496",
    "question": "What is associated with X-linked intellectual disability-cubitus valgus-dysmorphism syndrome?",
    "seeds": [
      "X-linked intellectual disability-cubitus valgus-dysmorphism syndrome"
    ],
    "gold_answer": "Slanting of the palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05497",
    "question": "What is associated with Neonatal bilateral clonic seizure?",
    "seeds": [
      "Neonatal bilateral clonic seizure"
    ],
    "gold_answer": "Neonatal electro-clinical seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05498",
    "question": "What is associated with Patchy osteosclerosis?",
    "seeds": [
      "Patchy osteosclerosis"
    ],
    "gold_answer": "Patchy changes of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05499",
    "question": "What is associated with MHC class I deficiency 2?",
    "seeds": [
      "MHC class I deficiency 2"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05500",
    "question": "What is associated with Scapuloperoneal spinal muscular atrophy?",
    "seeds": [
      "Scapuloperoneal spinal muscular atrophy"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05501",
    "question": "What is associated with Acrodermatitis continua of Hallopeau?",
    "seeds": [
      "Acrodermatitis continua of Hallopeau"
    ],
    "gold_answer": "IL36RN",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_05502",
    "question": "What is associated with Perilobular?",
    "seeds": [
      "Perilobular"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05503",
    "question": "What is associated with Mitochondrial complex II deficiency, nuclear type 4?",
    "seeds": [
      "Mitochondrial complex II deficiency, nuclear type 4"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05504",
    "question": "What phenotype is associated with Schizophrenia 4?",
    "seeds": [
      "Schizophrenia 4"
    ],
    "gold_answer": "Hyperprolinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05505",
    "question": "What phenotype is associated with Bile acid synthesis defect, congenital, 5?",
    "seeds": [
      "Bile acid synthesis defect, congenital, 5"
    ],
    "gold_answer": "Prolonged partial thromboplastin time",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05506",
    "question": "What phenotype is associated with BRESEK syndrome?",
    "seeds": [
      "BRESEK syndrome"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05507",
    "question": "What is associated with Spastic paraplegia 53, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 53, autosomal recessive"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05508",
    "question": "What is associated with History of high-pressure injection injury of the hand?",
    "seeds": [
      "History of high-pressure injection injury of the hand"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05509",
    "question": "What is associated with Aplasia/Hypoplasia of the 3rd toe?",
    "seeds": [
      "Aplasia/Hypoplasia of the 3rd toe"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05510",
    "question": "What is associated with Zygomycosis?",
    "seeds": [
      "Zygomycosis"
    ],
    "gold_answer": "Abnormal glucose homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05511",
    "question": "What is associated with Prominent nasal septum?",
    "seeds": [
      "Prominent nasal septum"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05512",
    "question": "What is associated with Decreased circulating transcobalamin II concentration?",
    "seeds": [
      "Decreased circulating transcobalamin II concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05513",
    "question": "What is associated with Supernumerary metacarpal bones?",
    "seeds": [
      "Supernumerary metacarpal bones"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05514",
    "question": "What is associated with Usher syndrome, type IF?",
    "seeds": [
      "Usher syndrome, type IF"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05515",
    "question": "What is associated with Abnormality of the epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Abnormality of the epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05516",
    "question": "What is associated with 2p25.3 microduplication syndrome?",
    "seeds": [
      "2p25.3 microduplication syndrome"
    ],
    "gold_answer": "MYT1L",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "role_in_the_phenotype_of"
    }
  },
  {
    "query_id": "orph_train_05517",
    "question": "What is associated with Triggered by allopurinol?",
    "seeds": [
      "Triggered by allopurinol"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05518",
    "question": "What is associated with Paroxysmal dyspnea?",
    "seeds": [
      "Paroxysmal dyspnea"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05519",
    "question": "What is associated with Elevated double-negative T cell proportion?",
    "seeds": [
      "Elevated double-negative T cell proportion"
    ],
    "gold_answer": "Abnormal double-negative T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05520",
    "question": "What is associated with Primary immunodeficiency syndrome due to P14/LAMTOR2 deficiency?",
    "seeds": [
      "Primary immunodeficiency syndrome due to P14/LAMTOR2 deficiency"
    ],
    "gold_answer": "Abnormal neutrophil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05521",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 89?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 89"
    ],
    "gold_answer": "Generalized myoclonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05522",
    "question": "What is associated with Palmaris longus muscle, absence of?",
    "seeds": [
      "Palmaris longus muscle, absence of"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05523",
    "question": "What is associated with Pulmonary nodule?",
    "seeds": [
      "Pulmonary nodule"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05524",
    "question": "What is associated with Chronic hemolytic anemia?",
    "seeds": [
      "Chronic hemolytic anemia"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05525",
    "question": "What is associated with Round humeral epiphyses?",
    "seeds": [
      "Round humeral epiphyses"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05526",
    "question": "What is associated with Warsaw breakage syndrome?",
    "seeds": [
      "Warsaw breakage syndrome"
    ],
    "gold_answer": "Syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05527",
    "question": "What is associated with Precocious puberty?",
    "seeds": [
      "Precocious puberty"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05528",
    "question": "What is associated with Hallux valgus?",
    "seeds": [
      "Hallux valgus"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05529",
    "question": "What is associated with Abnormal glomerular filtration rate?",
    "seeds": [
      "Abnormal glomerular filtration rate"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05530",
    "question": "What is associated with Generalized juvenile polyposis/juvenile polyposis coli?",
    "seeds": [
      "Generalized juvenile polyposis/juvenile polyposis coli"
    ],
    "gold_answer": "Bloody diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05531",
    "question": "What is associated with Decreased glucosephosphate isomerase level?",
    "seeds": [
      "Decreased glucosephosphate isomerase level"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05532",
    "question": "What is associated with Elevated urine 3-hydroxypropionic acid level?",
    "seeds": [
      "Elevated urine 3-hydroxypropionic acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05533",
    "question": "What is associated with Progressive calcification of costochondral cartilage?",
    "seeds": [
      "Progressive calcification of costochondral cartilage"
    ],
    "gold_answer": "Calcification of cartilage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05534",
    "question": "What phenotype is associated with Neutropenia, severe congenital, 8, autosomal dominant?",
    "seeds": [
      "Neutropenia, severe congenital, 8, autosomal dominant"
    ],
    "gold_answer": "Exocrine pancreatic insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05535",
    "question": "What is associated with Anti-centromere antibody positivity?",
    "seeds": [
      "Anti-centromere antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05536",
    "question": "What is associated with Radioulnar synostosis-microcephaly-scoliosis syndrome?",
    "seeds": [
      "Radioulnar synostosis-microcephaly-scoliosis syndrome"
    ],
    "gold_answer": "Limited elbow movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05537",
    "question": "What is associated with Elevated circulating sebacic acid concentration?",
    "seeds": [
      "Elevated circulating sebacic acid concentration"
    ],
    "gold_answer": "Abnormal circulating dicarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05538",
    "question": "What is associated with Absent aortic valve cusps?",
    "seeds": [
      "Absent aortic valve cusps"
    ],
    "gold_answer": "Abnormal aortic valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05539",
    "question": "What is associated with Lethal Kniest-like dysplasia?",
    "seeds": [
      "Lethal Kniest-like dysplasia"
    ],
    "gold_answer": "Limb undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05540",
    "question": "What is associated with Mowat-Wilson syndrome?",
    "seeds": [
      "Mowat-Wilson syndrome"
    ],
    "gold_answer": "Non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05541",
    "question": "What is associated with Chiari malformation?",
    "seeds": [
      "Chiari malformation"
    ],
    "gold_answer": "Abnormal hindbrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05542",
    "question": "What is associated with Parageusia?",
    "seeds": [
      "Parageusia"
    ],
    "gold_answer": "Abnormality of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05543",
    "question": "What is associated with Spastic triplegia?",
    "seeds": [
      "Spastic triplegia"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05544",
    "question": "What is associated with Cortical radial artery hypercellularity?",
    "seeds": [
      "Cortical radial artery hypercellularity"
    ],
    "gold_answer": "Abnormal intrarenal artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05545",
    "question": "What phenotype is associated with Kasabach-Merritt phenomenon?",
    "seeds": [
      "Kasabach-Merritt phenomenon"
    ],
    "gold_answer": "Hypertrichosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05546",
    "question": "What is associated with Increased pulmonary capillary wedge pressure?",
    "seeds": [
      "Increased pulmonary capillary wedge pressure"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05547",
    "question": "What is associated with Abnormal cellular physiology?",
    "seeds": [
      "Abnormal cellular physiology"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05548",
    "question": "What is associated with Ophthalmoparesis?",
    "seeds": [
      "Ophthalmoparesis"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05549",
    "question": "What is associated with Abnormality of the pancreatic islet cells?",
    "seeds": [
      "Abnormality of the pancreatic islet cells"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05550",
    "question": "What is associated with Increased fibular diameter?",
    "seeds": [
      "Increased fibular diameter"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05551",
    "question": "What is associated with Reduced circulating aspartate aminotransferase concentration?",
    "seeds": [
      "Reduced circulating aspartate aminotransferase concentration"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05552",
    "question": "What phenotype is associated with Congenital syphilis?",
    "seeds": [
      "Congenital syphilis"
    ],
    "gold_answer": "Petechiae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05553",
    "question": "What phenotype is associated with Microcephaly-cardiac defect-lung malsegmentation syndrome?",
    "seeds": [
      "Microcephaly-cardiac defect-lung malsegmentation syndrome"
    ],
    "gold_answer": "Abnormal lung lobation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05554",
    "question": "What is associated with Cold-induced sweating?",
    "seeds": [
      "Cold-induced sweating"
    ],
    "gold_answer": "Abnormality of skin adnexa physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05555",
    "question": "What is associated with Increased female libido?",
    "seeds": [
      "Increased female libido"
    ],
    "gold_answer": "Abnormal female reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05556",
    "question": "What is associated with Cervical myelopathy?",
    "seeds": [
      "Cervical myelopathy"
    ],
    "gold_answer": "Closed neural tube defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05557",
    "question": "What is associated with Unstable beta globin chain variant disease?",
    "seeds": [
      "Unstable beta globin chain variant disease"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05558",
    "question": "What is associated with Stage 5 chronic kidney disease?",
    "seeds": [
      "Stage 5 chronic kidney disease"
    ],
    "gold_answer": "Renal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05559",
    "question": "What phenotype is associated with Xp22.3 microdeletion syndrome?",
    "seeds": [
      "Xp22.3 microdeletion syndrome"
    ],
    "gold_answer": "Ectopic anus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05560",
    "question": "What is associated with Post-vaccination polio?",
    "seeds": [
      "Post-vaccination polio"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05561",
    "question": "What is associated with Aplasia/Hypoplasia of the maxilla?",
    "seeds": [
      "Aplasia/Hypoplasia of the maxilla"
    ],
    "gold_answer": "Abnormal maxilla morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05562",
    "question": "What is associated with Pulmonary arterial atherosclerosis?",
    "seeds": [
      "Pulmonary arterial atherosclerosis"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05563",
    "question": "What is associated with Spondylocostal dysostosis 3, autosomal recessive?",
    "seeds": [
      "Spondylocostal dysostosis 3, autosomal recessive"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05564",
    "question": "What is associated with Abnormality of cerebrosidase metabolism?",
    "seeds": [
      "Abnormality of cerebrosidase metabolism"
    ],
    "gold_answer": "Abnormality of glycolipid metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05565",
    "question": "What is associated with Severe cytomegalovirus infection?",
    "seeds": [
      "Severe cytomegalovirus infection"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05566",
    "question": "What is associated with Symphalangism, proximal, 1A?",
    "seeds": [
      "Symphalangism, proximal, 1A"
    ],
    "gold_answer": "Short metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05567",
    "question": "What phenotype is associated with Autoimmune disease, susceptibility to, 1?",
    "seeds": [
      "Autoimmune disease, susceptibility to, 1"
    ],
    "gold_answer": "Hashimoto thyroiditis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05568",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 44?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 44"
    ],
    "gold_answer": "Abnormality of peripheral nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05569",
    "question": "What phenotype is associated with Agenesis of corpus callosum, cardiac, ocular, and genital syndrome?",
    "seeds": [
      "Agenesis of corpus callosum, cardiac, ocular, and genital syndrome"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05570",
    "question": "What is associated with Laryngeal stenosis?",
    "seeds": [
      "Laryngeal stenosis"
    ],
    "gold_answer": "Abnormality of the larynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05571",
    "question": "What is associated with Premature ovarian failure 8?",
    "seeds": [
      "Premature ovarian failure 8"
    ],
    "gold_answer": "Hyperpituitarism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05572",
    "question": "What is associated with Abnormal lymph-node marginal or mantle zone morphology?",
    "seeds": [
      "Abnormal lymph-node marginal or mantle zone morphology"
    ],
    "gold_answer": "Abnormal lymph-node biospecimen",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05573",
    "question": "What is associated with Glomerular basement membrane lamellation?",
    "seeds": [
      "Glomerular basement membrane lamellation"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05574",
    "question": "What is associated with Autism-epilepsy syndrome due to branched chain ketoacid dehydrogenase kinase deficiency?",
    "seeds": [
      "Autism-epilepsy syndrome due to branched chain ketoacid dehydrogenase kinase deficiency"
    ],
    "gold_answer": "BCKDK",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_05575",
    "question": "What is associated with Decreased circulating complement component 1s concentration?",
    "seeds": [
      "Decreased circulating complement component 1s concentration"
    ],
    "gold_answer": "Reduced circulating complement concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05576",
    "question": "What phenotype is associated with Oocyte/zygote/embryo maturation arrest 24?",
    "seeds": [
      "Oocyte/zygote/embryo maturation arrest 24"
    ],
    "gold_answer": "Embryo developmental arrest",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05577",
    "question": "What is associated with Atypical absence status epilepticus?",
    "seeds": [
      "Atypical absence status epilepticus"
    ],
    "gold_answer": "Status epilepticus without prominent motor symptoms",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05578",
    "question": "What is associated with Wieacker-Wolff syndrome?",
    "seeds": [
      "Wieacker-Wolff syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05579",
    "question": "What is associated with X-linked combined immunodeficiency due to SASH3 deficiency?",
    "seeds": [
      "X-linked combined immunodeficiency due to SASH3 deficiency"
    ],
    "gold_answer": "SASH3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_05580",
    "question": "What is associated with Enlarged semicircular canal?",
    "seeds": [
      "Enlarged semicircular canal"
    ],
    "gold_answer": "Abnormal inner ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05581",
    "question": "What is associated with Very long chain acyl-CoA dehydrogenase deficiency?",
    "seeds": [
      "Very long chain acyl-CoA dehydrogenase deficiency"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05582",
    "question": "What is associated with Sarcoma?",
    "seeds": [
      "Sarcoma"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05583",
    "question": "What is associated with Increased QRS voltage?",
    "seeds": [
      "Increased QRS voltage"
    ],
    "gold_answer": "Abnormal QRS complex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05584",
    "question": "What is associated with Narrow maxilla?",
    "seeds": [
      "Narrow maxilla"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05585",
    "question": "What is associated with Skeletal muscle fibrosis?",
    "seeds": [
      "Skeletal muscle fibrosis"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05586",
    "question": "What is associated with Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1?",
    "seeds": [
      "Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05587",
    "question": "What is associated with Sandhoff disease, infantile form?",
    "seeds": [
      "Sandhoff disease, infantile form"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05588",
    "question": "What is associated with Pyknoachondrogenesis?",
    "seeds": [
      "Pyknoachondrogenesis"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05589",
    "question": "What is associated with Renal interstitial plasma cell infiltration?",
    "seeds": [
      "Renal interstitial plasma cell infiltration"
    ],
    "gold_answer": "Abnormal renal interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05590",
    "question": "What is associated with Facial nerve compression?",
    "seeds": [
      "Facial nerve compression"
    ],
    "gold_answer": "Abnormal cranial nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05591",
    "question": "What phenotype is associated with Hemolytic anemia due to glutathione reductase deficiency?",
    "seeds": [
      "Hemolytic anemia due to glutathione reductase deficiency"
    ],
    "gold_answer": "Fava bean-induced hemolytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05592",
    "question": "What is associated with Abnormal finger flexion crease?",
    "seeds": [
      "Abnormal finger flexion crease"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05593",
    "question": "What is associated with Subendothelial glomerular basement membrane electron dense deposits?",
    "seeds": [
      "Subendothelial glomerular basement membrane electron dense deposits"
    ],
    "gold_answer": "Glomerular basement membrane electron dense deposits",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05594",
    "question": "What is associated with Vulto-van Silfout-de Vries syndrome?",
    "seeds": [
      "Vulto-van Silfout-de Vries syndrome"
    ],
    "gold_answer": "Sacrococcygeal pilonidal abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05595",
    "question": "What is associated with Polycystic kidney disease 4 with or without polycystic liver disease?",
    "seeds": [
      "Polycystic kidney disease 4 with or without polycystic liver disease"
    ],
    "gold_answer": "Abnormal abdomen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05596",
    "question": "What phenotype is associated with Dopamine beta-hydroxylase, plasma, thermolability of?",
    "seeds": [
      "Dopamine beta-hydroxylase, plasma, thermolability of"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05597",
    "question": "What is associated with Aplasia/Hypoplasia of the biceps?",
    "seeds": [
      "Aplasia/Hypoplasia of the biceps"
    ],
    "gold_answer": "Abnormality of the musculature of the upper arm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05598",
    "question": "What is associated with Abnormal metacarpal ossification?",
    "seeds": [
      "Abnormal metacarpal ossification"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05599",
    "question": "What is associated with Triggered by nickel?",
    "seeds": [
      "Triggered by nickel"
    ],
    "gold_answer": "Triggered by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05600",
    "question": "What is associated with Postinfectious vasculitis?",
    "seeds": [
      "Postinfectious vasculitis"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05601",
    "question": "What is associated with Positive bloodstream plasmodium falciparum nucleic acid pathogen test?",
    "seeds": [
      "Positive bloodstream plasmodium falciparum nucleic acid pathogen test"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05602",
    "question": "What is associated with Bradypnea?",
    "seeds": [
      "Bradypnea"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05603",
    "question": "What is associated with Abnormal central sensory function?",
    "seeds": [
      "Abnormal central sensory function"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05604",
    "question": "What is associated with Phalangeal dislocation?",
    "seeds": [
      "Phalangeal dislocation"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05605",
    "question": "What phenotype is associated with Long QT syndrome 1?",
    "seeds": [
      "Long QT syndrome 1"
    ],
    "gold_answer": "Syncope",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05606",
    "question": "What phenotype is associated with Febrile seizures, familial, 8?",
    "seeds": [
      "Febrile seizures, familial, 8"
    ],
    "gold_answer": "Generalized non-motor (absence) seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05607",
    "question": "What is associated with Abnormal cardiac catheterization?",
    "seeds": [
      "Abnormal cardiac catheterization"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05608",
    "question": "What is associated with Abnormal sweat homeostasis?",
    "seeds": [
      "Abnormal sweat homeostasis"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05609",
    "question": "What phenotype is associated with Thrombophilia, hereditary, due to protein S deficiency, autosomal?",
    "seeds": [
      "Thrombophilia, hereditary, due to protein S deficiency, autosomal"
    ],
    "gold_answer": "Cerebral venous thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05610",
    "question": "What is associated with Patchy sclerosis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Patchy sclerosis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal distal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05611",
    "question": "What is associated with Hereditary late-onset Parkinson disease?",
    "seeds": [
      "Hereditary late-onset Parkinson disease"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05612",
    "question": "What is associated with Abnormal sweat electrolytes?",
    "seeds": [
      "Abnormal sweat electrolytes"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05613",
    "question": "What is associated with Medially deviated second toe?",
    "seeds": [
      "Medially deviated second toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05614",
    "question": "What is associated with Duplication of the 1st metatarsal?",
    "seeds": [
      "Duplication of the 1st metatarsal"
    ],
    "gold_answer": "Duplication of metatarsal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05615",
    "question": "What is associated with Abnormal circulating sarcosine concentration?",
    "seeds": [
      "Abnormal circulating sarcosine concentration"
    ],
    "gold_answer": "Abnormal circulating serine family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05616",
    "question": "What is associated with Congenital cataracts-facial dysmorphism-neuropathy syndrome?",
    "seeds": [
      "Congenital cataracts-facial dysmorphism-neuropathy syndrome"
    ],
    "gold_answer": "Kinetic tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05617",
    "question": "What is associated with Abnormality of the abdominal organs?",
    "seeds": [
      "Abnormality of the abdominal organs"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05618",
    "question": "What is associated with Short greater sciatic notch?",
    "seeds": [
      "Short greater sciatic notch"
    ],
    "gold_answer": "Abnormal greater sciatic notch morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05619",
    "question": "What is associated with Curved middle phalanx of the 2nd toe?",
    "seeds": [
      "Curved middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05620",
    "question": "What is associated with Agenesis of pulmonary vessels?",
    "seeds": [
      "Agenesis of pulmonary vessels"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05621",
    "question": "What is associated with Germinal centers with absent marginal zones?",
    "seeds": [
      "Germinal centers with absent marginal zones"
    ],
    "gold_answer": "Abnormal lymph-node marginal or mantle zone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05622",
    "question": "What is associated with Abnormal brain morphology?",
    "seeds": [
      "Abnormal brain morphology"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05623",
    "question": "What phenotype is associated with Neutropenia, severe congenital, X-linked?",
    "seeds": [
      "Neutropenia, severe congenital, X-linked"
    ],
    "gold_answer": "Decreased total monocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05624",
    "question": "What is associated with Abnormal form of the vertebral bodies?",
    "seeds": [
      "Abnormal form of the vertebral bodies"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05625",
    "question": "What phenotype is associated with Cyclic vomiting syndrome?",
    "seeds": [
      "Cyclic vomiting syndrome"
    ],
    "gold_answer": "Pallor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05626",
    "question": "What phenotype is associated with Chromosome 20q11-q12 deletion syndrome?",
    "seeds": [
      "Chromosome 20q11-q12 deletion syndrome"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05627",
    "question": "What phenotype is associated with Atrioventricular septal defect 5?",
    "seeds": [
      "Atrioventricular septal defect 5"
    ],
    "gold_answer": "Muscular ventricular septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05628",
    "question": "What is associated with Positive Quantiferon tuberculosis test?",
    "seeds": [
      "Positive Quantiferon tuberculosis test"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05629",
    "question": "What is associated with Elevated CSF myelin basic protein concentration?",
    "seeds": [
      "Elevated CSF myelin basic protein concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05630",
    "question": "What is associated with Abnormal radial metaphysis morphology?",
    "seeds": [
      "Abnormal radial metaphysis morphology"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05631",
    "question": "What is associated with Pachydermodactyly, familial?",
    "seeds": [
      "Pachydermodactyly, familial"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05632",
    "question": "What is associated with Cardiomyopathy?",
    "seeds": [
      "Cardiomyopathy"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05633",
    "question": "What is associated with von Willebrand disease, type 3?",
    "seeds": [
      "von Willebrand disease, type 3"
    ],
    "gold_answer": "Prolonged bleeding following procedure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05634",
    "question": "What is associated with Agenesis of maxillary incisor?",
    "seeds": [
      "Agenesis of maxillary incisor"
    ],
    "gold_answer": "Abnormal number of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05635",
    "question": "What is associated with Microcephaly 4, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 4, primary, autosomal recessive"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05636",
    "question": "What is associated with Prostate cancer, hereditary, X-linked 1?",
    "seeds": [
      "Prostate cancer, hereditary, X-linked 1"
    ],
    "gold_answer": "Prostate neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05637",
    "question": "What is associated with Conjunctival fornix foreshortening?",
    "seeds": [
      "Conjunctival fornix foreshortening"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05638",
    "question": "What is associated with Neutropenia, severe congenital, 1, autosomal dominant?",
    "seeds": [
      "Neutropenia, severe congenital, 1, autosomal dominant"
    ],
    "gold_answer": "Abnormal total eosinophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05639",
    "question": "What is associated with Right ventricular noncompaction cardiomyopathy?",
    "seeds": [
      "Right ventricular noncompaction cardiomyopathy"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05640",
    "question": "What is associated with Mitochondrial complex IV deficiency, nuclear type 5, (French-Canadian)?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 5, (French-Canadian)"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05641",
    "question": "What is associated with Freckling?",
    "seeds": [
      "Freckling"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05642",
    "question": "What is associated with Inferior lens subluxation?",
    "seeds": [
      "Inferior lens subluxation"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05643",
    "question": "What is associated with Decreased level of platelet-activating factor?",
    "seeds": [
      "Decreased level of platelet-activating factor"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05644",
    "question": "What is associated with Renal arteriole intima/media necrosis?",
    "seeds": [
      "Renal arteriole intima/media necrosis"
    ],
    "gold_answer": "Abnormal renal arteriole morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05645",
    "question": "What is associated with Abnormality of the middle ear ossicles?",
    "seeds": [
      "Abnormality of the middle ear ossicles"
    ],
    "gold_answer": "Abnormal middle ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05646",
    "question": "What phenotype is associated with Nevus flammeus of nape of neck?",
    "seeds": [
      "Nevus flammeus of nape of neck"
    ],
    "gold_answer": "Nevus flammeus nuchae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05647",
    "question": "What phenotype is associated with Pontocerebellar hypoplasia, type 2A?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 2A"
    ],
    "gold_answer": "Optic atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05648",
    "question": "What is associated with Circulating immune complexes?",
    "seeds": [
      "Circulating immune complexes"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05649",
    "question": "What phenotype is associated with Fanconi anemia, complementation group S?",
    "seeds": [
      "Fanconi anemia, complementation group S"
    ],
    "gold_answer": "Low anterior hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05650",
    "question": "What is associated with Urinary bladder mass?",
    "seeds": [
      "Urinary bladder mass"
    ],
    "gold_answer": "Abnormal bladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05651",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 18, with or without epilepsy?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 18, with or without epilepsy"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05652",
    "question": "What is associated with Glioma susceptibility 2?",
    "seeds": [
      "Glioma susceptibility 2"
    ],
    "gold_answer": "Ophthalmoparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05653",
    "question": "What is associated with Reduced respiratory ciliary beating frequency?",
    "seeds": [
      "Reduced respiratory ciliary beating frequency"
    ],
    "gold_answer": "Abnormal respiratory motile cilium physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05654",
    "question": "What is associated with Irregular respiration?",
    "seeds": [
      "Irregular respiration"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05655",
    "question": "What is associated with Absent scaphoid?",
    "seeds": [
      "Absent scaphoid"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05656",
    "question": "What is associated with Neurodevelopmental disorder with seizures and speech and walking impairment?",
    "seeds": [
      "Neurodevelopmental disorder with seizures and speech and walking impairment"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05657",
    "question": "What is associated with Spastic paraplegia 30, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 30, autosomal recessive"
    ],
    "gold_answer": "Impaired vibratory sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05658",
    "question": "What is associated with ANDROSTENONE, ABILITY TO SMELL?",
    "seeds": [
      "ANDROSTENONE, ABILITY TO SMELL"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05659",
    "question": "What is associated with Vaginal hydrocele?",
    "seeds": [
      "Vaginal hydrocele"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05660",
    "question": "What phenotype is associated with Microcephalic osteodysplastic primordial dwarfism types I and III?",
    "seeds": [
      "Microcephalic osteodysplastic primordial dwarfism types I and III"
    ],
    "gold_answer": "Cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05661",
    "question": "What is associated with Atrial fibrillation, familial, 13?",
    "seeds": [
      "Atrial fibrillation, familial, 13"
    ],
    "gold_answer": "Atrial arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05662",
    "question": "What is associated with Hypokalemic hypochloremic metabolic alkalosis?",
    "seeds": [
      "Hypokalemic hypochloremic metabolic alkalosis"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05663",
    "question": "What is associated with Attenuation of retinal blood vessels?",
    "seeds": [
      "Attenuation of retinal blood vessels"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05664",
    "question": "What is associated with Focal aware motor seizure with dystonia?",
    "seeds": [
      "Focal aware motor seizure with dystonia"
    ],
    "gold_answer": "Focal aware motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05665",
    "question": "What is associated with Rapidly progressive?",
    "seeds": [
      "Rapidly progressive"
    ],
    "gold_answer": "Progressive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05666",
    "question": "What phenotype is associated with Immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias?",
    "seeds": [
      "Immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias"
    ],
    "gold_answer": "Absent specific antibody response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05667",
    "question": "What is associated with Tessier number 5 facial cleft?",
    "seeds": [
      "Tessier number 5 facial cleft"
    ],
    "gold_answer": "Tessier cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05668",
    "question": "What is associated with Abnormality of Krebs cycle metabolism?",
    "seeds": [
      "Abnormality of Krebs cycle metabolism"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05669",
    "question": "What is associated with Holster sign?",
    "seeds": [
      "Holster sign"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05670",
    "question": "What is associated with Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin?",
    "seeds": [
      "Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05671",
    "question": "What phenotype is associated with Complement component 8 deficiency, type I?",
    "seeds": [
      "Complement component 8 deficiency, type I"
    ],
    "gold_answer": "Thrombocytopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05672",
    "question": "What phenotype is associated with Pseudoatrophoderma colli?",
    "seeds": [
      "Pseudoatrophoderma colli"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05673",
    "question": "What is associated with White streaks/specks on enamel.?",
    "seeds": [
      "White streaks/specks on enamel."
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05674",
    "question": "What is associated with Abnormal blood carbon dioxide level?",
    "seeds": [
      "Abnormal blood carbon dioxide level"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05675",
    "question": "What phenotype is associated with Autosomal recessive centronuclear myopathy?",
    "seeds": [
      "Autosomal recessive centronuclear myopathy"
    ],
    "gold_answer": "Long fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05676",
    "question": "What is associated with Metaphyseal dysplasia?",
    "seeds": [
      "Metaphyseal dysplasia"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05677",
    "question": "What is associated with Intellectual developmental disorder, X-linked syndromic, Raymond type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic, Raymond type"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05678",
    "question": "What is associated with Tessadori-van Haaften neurodevelopmental syndrome 2?",
    "seeds": [
      "Tessadori-van Haaften neurodevelopmental syndrome 2"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05679",
    "question": "What is associated with Metaphyseal chondromatosis of ulna?",
    "seeds": [
      "Metaphyseal chondromatosis of ulna"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05680",
    "question": "What is associated with Cardiomyopathy, dilated, with woolly hair and keratoderma?",
    "seeds": [
      "Cardiomyopathy, dilated, with woolly hair and keratoderma"
    ],
    "gold_answer": "Hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05681",
    "question": "What phenotype is associated with Autosomal dominant progressive external ophthalmoplegia?",
    "seeds": [
      "Autosomal dominant progressive external ophthalmoplegia"
    ],
    "gold_answer": "Difficulty climbing stairs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05682",
    "question": "What is associated with Elevated urinary pipecolic acid level?",
    "seeds": [
      "Elevated urinary pipecolic acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05683",
    "question": "What phenotype is associated with Presynaptic congenital myasthenic syndromes?",
    "seeds": [
      "Presynaptic congenital myasthenic syndromes"
    ],
    "gold_answer": "Motor polyneuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05684",
    "question": "What is associated with Class I glucose-6-phosphate dehydrogenase deficiency?",
    "seeds": [
      "Class I glucose-6-phosphate dehydrogenase deficiency"
    ],
    "gold_answer": "G6PD",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_05685",
    "question": "What is associated with Cone-shaped epiphyses of the phalanges of the hand?",
    "seeds": [
      "Cone-shaped epiphyses of the phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05686",
    "question": "What is associated with Developmental and epileptic encephalopathy 109?",
    "seeds": [
      "Developmental and epileptic encephalopathy 109"
    ],
    "gold_answer": "Focal motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05687",
    "question": "What is associated with 3-methylglutaconic aciduria, type IX?",
    "seeds": [
      "3-methylglutaconic aciduria, type IX"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05688",
    "question": "What is associated with 3-4 toe cutaneous syndactyly?",
    "seeds": [
      "3-4 toe cutaneous syndactyly"
    ],
    "gold_answer": "Cutaneous syndactyly of toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05689",
    "question": "What is associated with Ash-leaf spot?",
    "seeds": [
      "Ash-leaf spot"
    ],
    "gold_answer": "Hypopigmented macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05690",
    "question": "What is associated with Vaginal hernia?",
    "seeds": [
      "Vaginal hernia"
    ],
    "gold_answer": "Abnormal vagina morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05691",
    "question": "What is associated with Long palm?",
    "seeds": [
      "Long palm"
    ],
    "gold_answer": "Abnormal palm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05692",
    "question": "What is associated with Spermatogenic failure 102?",
    "seeds": [
      "Spermatogenic failure 102"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05693",
    "question": "What is associated with Anomalous origin of coronary artery from the pulmonary artery?",
    "seeds": [
      "Anomalous origin of coronary artery from the pulmonary artery"
    ],
    "gold_answer": "Abnormal coronary artery origin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05694",
    "question": "What is associated with Abnormal cellular immune system morphology?",
    "seeds": [
      "Abnormal cellular immune system morphology"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05695",
    "question": "What is associated with Gastroesophageal reflux?",
    "seeds": [
      "Gastroesophageal reflux"
    ],
    "gold_answer": "Neoplasm of head and neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05696",
    "question": "What is associated with Neurite dystrophy?",
    "seeds": [
      "Neurite dystrophy"
    ],
    "gold_answer": "Abnormal neuron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05697",
    "question": "What phenotype is associated with Mucopolysaccharidosis type IVB (Morquio)?",
    "seeds": [
      "Mucopolysaccharidosis type IVB (Morquio)"
    ],
    "gold_answer": "Cervical subluxation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05698",
    "question": "What is associated with Hypersegmentation of proximal phalanx of third finger?",
    "seeds": [
      "Hypersegmentation of proximal phalanx of third finger"
    ],
    "gold_answer": "Abnormality of the proximal phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05699",
    "question": "What is associated with Arcuate vein intima/medial amyloidosis?",
    "seeds": [
      "Arcuate vein intima/medial amyloidosis"
    ],
    "gold_answer": "Abnormal arcuate vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05700",
    "question": "What is associated with Abnormal KCO?",
    "seeds": [
      "Abnormal KCO"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05701",
    "question": "What is associated with Meier-Gorlin syndrome 8?",
    "seeds": [
      "Meier-Gorlin syndrome 8"
    ],
    "gold_answer": "Abnormal localization of kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05702",
    "question": "What is associated with Anti-SARS-CoV-2 coronavirus antibody positivity?",
    "seeds": [
      "Anti-SARS-CoV-2 coronavirus antibody positivity"
    ],
    "gold_answer": "Bloodstream virus-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05703",
    "question": "What is associated with Oxoglutarate dehydrogenase deficiency?",
    "seeds": [
      "Oxoglutarate dehydrogenase deficiency"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05704",
    "question": "What is associated with Bowing of limbs due to multiple fractures?",
    "seeds": [
      "Bowing of limbs due to multiple fractures"
    ],
    "gold_answer": "Increased susceptibility to fractures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05705",
    "question": "What is associated with Myopathy, myofibrillar, 3?",
    "seeds": [
      "Myopathy, myofibrillar, 3"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05706",
    "question": "What phenotype is associated with Microcephaly 8, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 8, primary, autosomal recessive"
    ],
    "gold_answer": "Retrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05707",
    "question": "What phenotype is associated with Complete androgen insensitivity syndrome?",
    "seeds": [
      "Complete androgen insensitivity syndrome"
    ],
    "gold_answer": "Male infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05708",
    "question": "What is associated with Sterile arthritis?",
    "seeds": [
      "Sterile arthritis"
    ],
    "gold_answer": "Arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05709",
    "question": "What phenotype is associated with Cowden syndrome 6?",
    "seeds": [
      "Cowden syndrome 6"
    ],
    "gold_answer": "Breast carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05710",
    "question": "What is associated with Insulin-dependent but ketosis-resistant diabetes?",
    "seeds": [
      "Insulin-dependent but ketosis-resistant diabetes"
    ],
    "gold_answer": "Diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05711",
    "question": "What is associated with Wilms tumor 5?",
    "seeds": [
      "Wilms tumor 5"
    ],
    "gold_answer": "H19",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "role_in_the_phenotype_of"
    }
  },
  {
    "query_id": "orph_train_05712",
    "question": "What is associated with Triangular shaped proximal phalanx of the thumb?",
    "seeds": [
      "Triangular shaped proximal phalanx of the thumb"
    ],
    "gold_answer": "Triangular shaped middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05713",
    "question": "What is associated with Houge-Janssens syndrome 4?",
    "seeds": [
      "Houge-Janssens syndrome 4"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05714",
    "question": "What is associated with Localized soft-tissue swelling on extremity?",
    "seeds": [
      "Localized soft-tissue swelling on extremity"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05715",
    "question": "What is associated with Pancreatic pseudocyst?",
    "seeds": [
      "Pancreatic pseudocyst"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05716",
    "question": "What is associated with Fractured proximal phalanx of pedal digit 1?",
    "seeds": [
      "Fractured proximal phalanx of pedal digit 1"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05717",
    "question": "What phenotype is associated with Parathyroid carcinoma?",
    "seeds": [
      "Parathyroid carcinoma"
    ],
    "gold_answer": "Nephroblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05718",
    "question": "What is associated with Second finger symphalangism?",
    "seeds": [
      "Second finger symphalangism"
    ],
    "gold_answer": "Abnormality of the phalanges of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05719",
    "question": "What is associated with Anti-GD1a IgM antibody positivity?",
    "seeds": [
      "Anti-GD1a IgM antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05720",
    "question": "What is associated with Reduced impulse control?",
    "seeds": [
      "Reduced impulse control"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05721",
    "question": "What is associated with Tetraplegia?",
    "seeds": [
      "Tetraplegia"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05722",
    "question": "What is associated with Hypogonadotropic hypogonadism 10 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 10 with or without anosmia"
    ],
    "gold_answer": "Abnormal circulating testosterone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05723",
    "question": "What is associated with Agammaglobulinemia 9, autosomal recessive?",
    "seeds": [
      "Agammaglobulinemia 9, autosomal recessive"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05724",
    "question": "What is associated with Popcorn calcification?",
    "seeds": [
      "Popcorn calcification"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05725",
    "question": "What is associated with Contractural arachnodactyly, congenital?",
    "seeds": [
      "Contractural arachnodactyly, congenital"
    ],
    "gold_answer": "Abnormal atrioventricular valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05726",
    "question": "What is associated with Epilepsy, progressive myoclonic 7?",
    "seeds": [
      "Epilepsy, progressive myoclonic 7"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05727",
    "question": "What is associated with Elevated bone scintigraphy uptake?",
    "seeds": [
      "Elevated bone scintigraphy uptake"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05728",
    "question": "What phenotype is associated with Respiratory papillomatosis, juvenile recurrent, congenital?",
    "seeds": [
      "Respiratory papillomatosis, juvenile recurrent, congenital"
    ],
    "gold_answer": "Laryngeal papilloma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05729",
    "question": "What phenotype is associated with Pulmonary nodular lymphoid hyperplasia?",
    "seeds": [
      "Pulmonary nodular lymphoid hyperplasia"
    ],
    "gold_answer": "Chest pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05730",
    "question": "What phenotype is associated with Velocardiofacial syndrome?",
    "seeds": [
      "Velocardiofacial syndrome"
    ],
    "gold_answer": "Preauricular pit",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05731",
    "question": "What is associated with Lipid-laden lymph node macrophages?",
    "seeds": [
      "Lipid-laden lymph node macrophages"
    ],
    "gold_answer": "Abnormal lymph node cell composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05732",
    "question": "What is associated with Ichthyosis, congenital, autosomal recessive 9?",
    "seeds": [
      "Ichthyosis, congenital, autosomal recessive 9"
    ],
    "gold_answer": "Hypohidrosis or hyperhidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05733",
    "question": "What is associated with Distal anoctaminopathy?",
    "seeds": [
      "Distal anoctaminopathy"
    ],
    "gold_answer": "Elevated circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05734",
    "question": "What is associated with Auditory hypersensitivity?",
    "seeds": [
      "Auditory hypersensitivity"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05735",
    "question": "What is associated with Night blindness, congenital stationary, autosomal dominant 3?",
    "seeds": [
      "Night blindness, congenital stationary, autosomal dominant 3"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05736",
    "question": "What phenotype is associated with Ribbing disease?",
    "seeds": [
      "Ribbing disease"
    ],
    "gold_answer": "Diaphyseal sclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05737",
    "question": "What phenotype is associated with Calcification of joints and arteries?",
    "seeds": [
      "Calcification of joints and arteries"
    ],
    "gold_answer": "Iliac arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05738",
    "question": "What is associated with Focal aware sensory seizure?",
    "seeds": [
      "Focal aware sensory seizure"
    ],
    "gold_answer": "Focal aware non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05739",
    "question": "What is associated with Gottron sign?",
    "seeds": [
      "Gottron sign"
    ],
    "gold_answer": "Macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05740",
    "question": "What is associated with Cone-shaped epiphysis of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Cone-shaped epiphysis of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormal 2nd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05741",
    "question": "What is associated with Focal impaired awareness sensory seizure with auditory features?",
    "seeds": [
      "Focal impaired awareness sensory seizure with auditory features"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05742",
    "question": "What phenotype is associated with Keratoendotheliitis fugax hereditaria?",
    "seeds": [
      "Keratoendotheliitis fugax hereditaria"
    ],
    "gold_answer": "Conjunctival hyperemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05743",
    "question": "What is associated with Abnormal morphology of the chest musculature?",
    "seeds": [
      "Abnormal morphology of the chest musculature"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05744",
    "question": "What is associated with Fetal methamphetamine exposure?",
    "seeds": [
      "Fetal methamphetamine exposure"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05745",
    "question": "What is associated with Abnormal iliac wing morphology?",
    "seeds": [
      "Abnormal iliac wing morphology"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05746",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia, Li-Shao-Li type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, Li-Shao-Li type"
    ],
    "gold_answer": "Abnormality of the vertebral endplates",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05747",
    "question": "What is associated with Autosomal dominant intermediate Charcot-Marie-Tooth disease with neuropathic pain?",
    "seeds": [
      "Autosomal dominant intermediate Charcot-Marie-Tooth disease with neuropathic pain"
    ],
    "gold_answer": "MPZ",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_05748",
    "question": "What is associated with Bilateral choanal atresia?",
    "seeds": [
      "Bilateral choanal atresia"
    ],
    "gold_answer": "Abnormal eating behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05749",
    "question": "What is associated with Aminoaciduria?",
    "seeds": [
      "Aminoaciduria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05750",
    "question": "What is associated with Gastric lymphoma?",
    "seeds": [
      "Gastric lymphoma"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05751",
    "question": "What is associated with Decreased circulating ceruloplasmin concentration?",
    "seeds": [
      "Decreased circulating ceruloplasmin concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05752",
    "question": "What is associated with Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy?",
    "seeds": [
      "Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy"
    ],
    "gold_answer": "Atrophy/Degeneration involving the caudate nucleus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05753",
    "question": "What is associated with Cardiomyopathy, dilated, 1R?",
    "seeds": [
      "Cardiomyopathy, dilated, 1R"
    ],
    "gold_answer": "Abnormal left ventricular end-diastolic volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05754",
    "question": "What is associated with Exodeviation?",
    "seeds": [
      "Exodeviation"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05755",
    "question": "What is associated with Postmenopausal bleeding?",
    "seeds": [
      "Postmenopausal bleeding"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05756",
    "question": "What is associated with Spondylomegaepiphyseal dysplasia with upper limb mesomelia, punctatecalcifications, and deafness?",
    "seeds": [
      "Spondylomegaepiphyseal dysplasia with upper limb mesomelia, punctatecalcifications, and deafness"
    ],
    "gold_answer": "Abnormal epiphyseal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05757",
    "question": "What is associated with Czech dysplasia, Metatarsal type?",
    "seeds": [
      "Czech dysplasia, Metatarsal type"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the femoral head and neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05758",
    "question": "What is associated with Abnormal premolar morphology?",
    "seeds": [
      "Abnormal premolar morphology"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05759",
    "question": "What is associated with Non-specific autoimmune supratentorial encephalitis with characteristic antibodies?",
    "seeds": [
      "Non-specific autoimmune supratentorial encephalitis with characteristic antibodies"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05760",
    "question": "What is associated with Enamel pearls?",
    "seeds": [
      "Enamel pearls"
    ],
    "gold_answer": "Abnormal dental enamel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05761",
    "question": "What is associated with Triangular epiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Triangular epiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Triangular epiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05762",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2B?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2B"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05763",
    "question": "What is associated with Loud snoring?",
    "seeds": [
      "Loud snoring"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05764",
    "question": "What is associated with Bracket epiphysis of the 1st metacarpal?",
    "seeds": [
      "Bracket epiphysis of the 1st metacarpal"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05765",
    "question": "What is associated with Derealization?",
    "seeds": [
      "Derealization"
    ],
    "gold_answer": "Abnormal perceptual state",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05766",
    "question": "What phenotype is associated with Rhabdomyosarcoma, embryonal, 2?",
    "seeds": [
      "Rhabdomyosarcoma, embryonal, 2"
    ],
    "gold_answer": "Ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05767",
    "question": "What is associated with Congenital heart defects, multiple types, 4?",
    "seeds": [
      "Congenital heart defects, multiple types, 4"
    ],
    "gold_answer": "Congenital malformation of the great arteries",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05768",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 6?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 6"
    ],
    "gold_answer": "Abnormality of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05769",
    "question": "What is associated with Decorticate rigidity?",
    "seeds": [
      "Decorticate rigidity"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05770",
    "question": "What is associated with Hydroxylysinuria?",
    "seeds": [
      "Hydroxylysinuria"
    ],
    "gold_answer": "Increased aspartate family amino acid level in urine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05771",
    "question": "What is associated with Ameliorated by pyridoxal phosphate?",
    "seeds": [
      "Ameliorated by pyridoxal phosphate"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05772",
    "question": "What phenotype is associated with Late-onset distal myopathy, Markesbery-Griggs type?",
    "seeds": [
      "Late-onset distal myopathy, Markesbery-Griggs type"
    ],
    "gold_answer": "Foot dorsiflexor weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05773",
    "question": "What is associated with Myopia-3?",
    "seeds": [
      "Myopia-3"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05774",
    "question": "What is associated with Squamous metaplasia?",
    "seeds": [
      "Squamous metaplasia"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05775",
    "question": "What is associated with Aphakia?",
    "seeds": [
      "Aphakia"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05776",
    "question": "What is associated with Ullrich congenital muscular dystrophy?",
    "seeds": [
      "Ullrich congenital muscular dystrophy"
    ],
    "gold_answer": "Limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05777",
    "question": "What is associated with Eye poking?",
    "seeds": [
      "Eye poking"
    ],
    "gold_answer": "Stereotypic movements of face and head",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05778",
    "question": "What is associated with Intellectual disability-facial dysmorphism-hand anomalies syndrome?",
    "seeds": [
      "Intellectual disability-facial dysmorphism-hand anomalies syndrome"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05779",
    "question": "What is associated with Muscular dystrophy, limb-girdle, type 2D?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, type 2D"
    ],
    "gold_answer": "Myopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05780",
    "question": "What is associated with Frontal encephalocele?",
    "seeds": [
      "Frontal encephalocele"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05781",
    "question": "What is associated with Erythrocyte inclusion bodies?",
    "seeds": [
      "Erythrocyte inclusion bodies"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05782",
    "question": "What is associated with Increased level of hexanoylglycine in urine?",
    "seeds": [
      "Increased level of hexanoylglycine in urine"
    ],
    "gold_answer": "Abnormal urine hexanoylglycine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05783",
    "question": "What is associated with Hyperpigmented genitalia?",
    "seeds": [
      "Hyperpigmented genitalia"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05784",
    "question": "What is associated with Genu recurvatum?",
    "seeds": [
      "Genu recurvatum"
    ],
    "gold_answer": "Abnormality of the knee",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05785",
    "question": "What is associated with Focal autonomic seizure with pallor/flushing?",
    "seeds": [
      "Focal autonomic seizure with pallor/flushing"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05786",
    "question": "What is associated with Reduced imaginative play skills?",
    "seeds": [
      "Reduced imaginative play skills"
    ],
    "gold_answer": "Abnormal play",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05787",
    "question": "What is associated with Triggered by volatile organic compounds?",
    "seeds": [
      "Triggered by volatile organic compounds"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05788",
    "question": "What is associated with Abnormal number of erythroid precursors?",
    "seeds": [
      "Abnormal number of erythroid precursors"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05789",
    "question": "What phenotype is associated with Spinocerebellar degeneration with macular corneal dystrophy, congenitalcataracts, and myopia?",
    "seeds": [
      "Spinocerebellar degeneration with macular corneal dystrophy, congenitalcataracts, and myopia"
    ],
    "gold_answer": "Spastic ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05790",
    "question": "What is associated with 1q21.1 microdeletion syndrome?",
    "seeds": [
      "1q21.1 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05791",
    "question": "What is associated with Congenital megacalycosis?",
    "seeds": [
      "Congenital megacalycosis"
    ],
    "gold_answer": "Abnormality of the ureter",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05792",
    "question": "What is associated with Best corrected visual acuity 0.9 LogMAR?",
    "seeds": [
      "Best corrected visual acuity 0.9 LogMAR"
    ],
    "gold_answer": "Abnormal best corrected visual acuity test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05793",
    "question": "What phenotype is associated with Neuropathy, hereditary motor, with myopathic features?",
    "seeds": [
      "Neuropathy, hereditary motor, with myopathic features"
    ],
    "gold_answer": "Distal lower limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05794",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 43?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 43"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05795",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 18, with or without epilepsy?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 18, with or without epilepsy"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05796",
    "question": "What is associated with Vitamin B12-unresponsive methylmalonic acidemia type mut-?",
    "seeds": [
      "Vitamin B12-unresponsive methylmalonic acidemia type mut-"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05797",
    "question": "What is associated with EMG abnormality?",
    "seeds": [
      "EMG abnormality"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05798",
    "question": "What is associated with 2-3 toe cutaneous syndactyly?",
    "seeds": [
      "2-3 toe cutaneous syndactyly"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05799",
    "question": "What is associated with Low 1-minute APGAR score?",
    "seeds": [
      "Low 1-minute APGAR score"
    ],
    "gold_answer": "Low APGAR score",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05800",
    "question": "What is associated with Mesial parasagittal subcortical heterotopia?",
    "seeds": [
      "Mesial parasagittal subcortical heterotopia"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05801",
    "question": "What is associated with Familial cold autoinflammatory syndrome 4?",
    "seeds": [
      "Familial cold autoinflammatory syndrome 4"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05802",
    "question": "What is associated with Discoid lupus erythematosus?",
    "seeds": [
      "Discoid lupus erythematosus"
    ],
    "gold_answer": "Telangiectasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05803",
    "question": "What is associated with Hypochondriac delusion?",
    "seeds": [
      "Hypochondriac delusion"
    ],
    "gold_answer": "Delusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05804",
    "question": "What is associated with Abnormality of the proximal humeral epiphysis?",
    "seeds": [
      "Abnormality of the proximal humeral epiphysis"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05805",
    "question": "What is associated with Volvulus of midgut?",
    "seeds": [
      "Volvulus of midgut"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05806",
    "question": "What is associated with Septate gallbladder?",
    "seeds": [
      "Septate gallbladder"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05807",
    "question": "What is associated with High myopia?",
    "seeds": [
      "High myopia"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05808",
    "question": "What is associated with Intention tremor?",
    "seeds": [
      "Intention tremor"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05809",
    "question": "What is associated with Combined immunodeficiency due to DOCK8 deficiency?",
    "seeds": [
      "Combined immunodeficiency due to DOCK8 deficiency"
    ],
    "gold_answer": "Papilloma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05810",
    "question": "What phenotype is associated with Non-syndromic unicoronal craniosynostosis?",
    "seeds": [
      "Non-syndromic unicoronal craniosynostosis"
    ],
    "gold_answer": "Papilledema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05811",
    "question": "What phenotype is associated with Acne inversa, familial, 2, with or without dowling-degos disease?",
    "seeds": [
      "Acne inversa, familial, 2, with or without dowling-degos disease"
    ],
    "gold_answer": "Squamous cell carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05812",
    "question": "What is associated with Abnormal glomerular parietal epithelial cell morphology?",
    "seeds": [
      "Abnormal glomerular parietal epithelial cell morphology"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05813",
    "question": "What is associated with Hypoganglionosis?",
    "seeds": [
      "Hypoganglionosis"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05814",
    "question": "What is associated with Intraaxonal accumulation of curvilinear autofluorescent lipopigment storage material?",
    "seeds": [
      "Intraaxonal accumulation of curvilinear autofluorescent lipopigment storage material"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05815",
    "question": "What is associated with Congenital disorder of glycosylation, type IIh?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIh"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the mandible",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05816",
    "question": "What is associated with Angiosarcoma?",
    "seeds": [
      "Angiosarcoma"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05817",
    "question": "What is associated with Focal impaired awareness sensory seizure with gustatory features?",
    "seeds": [
      "Focal impaired awareness sensory seizure with gustatory features"
    ],
    "gold_answer": "Focal impaired awareness seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05818",
    "question": "What is associated with Agammaglobulinemia 8, autosomal dominant?",
    "seeds": [
      "Agammaglobulinemia 8, autosomal dominant"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05819",
    "question": "What is associated with Abnormal motor neuron morphology?",
    "seeds": [
      "Abnormal motor neuron morphology"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05820",
    "question": "What is associated with Radius, aplasia of, with cleft lip/palate?",
    "seeds": [
      "Radius, aplasia of, with cleft lip/palate"
    ],
    "gold_answer": "Aplasia involving forearm bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05821",
    "question": "What is associated with Hypotrichosis-Lymphedema-Telangiectasia-Renal defect syndrome?",
    "seeds": [
      "Hypotrichosis-Lymphedema-Telangiectasia-Renal defect syndrome"
    ],
    "gold_answer": "Abnormal scalp morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05822",
    "question": "What is associated with Atypical pulmonary carcinoid tumor?",
    "seeds": [
      "Atypical pulmonary carcinoid tumor"
    ],
    "gold_answer": "Carcinoid tumor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05823",
    "question": "What is associated with Acute necrotizing encephalopathy?",
    "seeds": [
      "Acute necrotizing encephalopathy"
    ],
    "gold_answer": "Encephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05824",
    "question": "What is associated with Abnormal amyloid beta 40 peptide CSF concentration?",
    "seeds": [
      "Abnormal amyloid beta 40 peptide CSF concentration"
    ],
    "gold_answer": "Abnormal amyloid beta peptide CSF concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05825",
    "question": "What phenotype is associated with Epidermolysis bullosa acquisita?",
    "seeds": [
      "Epidermolysis bullosa acquisita"
    ],
    "gold_answer": "Abdominal pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05826",
    "question": "What is associated with Small cervical vertebral bodies?",
    "seeds": [
      "Small cervical vertebral bodies"
    ],
    "gold_answer": "Hypoplastic vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05827",
    "question": "What is associated with Bilateral microphthalmos?",
    "seeds": [
      "Bilateral microphthalmos"
    ],
    "gold_answer": "Aplasia/Hypoplasia affecting the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05828",
    "question": "What is associated with Distal deletion 10q syndrome?",
    "seeds": [
      "Distal deletion 10q syndrome"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05829",
    "question": "What is associated with Abnormal skull base morphology?",
    "seeds": [
      "Abnormal skull base morphology"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05830",
    "question": "What is associated with Delayed calcaneal ossification?",
    "seeds": [
      "Delayed calcaneal ossification"
    ],
    "gold_answer": "Abnormal tarsal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05831",
    "question": "What is associated with Ameliorated by carbohydrate ingestion?",
    "seeds": [
      "Ameliorated by carbohydrate ingestion"
    ],
    "gold_answer": "Ameliorated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05832",
    "question": "What is associated with Motor delay?",
    "seeds": [
      "Motor delay"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05833",
    "question": "What is associated with Abnormal nasal cartilage morphology?",
    "seeds": [
      "Abnormal nasal cartilage morphology"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05834",
    "question": "What is associated with Short distal phalanx of hallux?",
    "seeds": [
      "Short distal phalanx of hallux"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05835",
    "question": "What is associated with Episodic hypoventilation?",
    "seeds": [
      "Episodic hypoventilation"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05836",
    "question": "What is associated with Optic atrophy 7 with or without auditory neuropathy?",
    "seeds": [
      "Optic atrophy 7 with or without auditory neuropathy"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05837",
    "question": "What is associated with Focal aware cognitive seizure with anomia?",
    "seeds": [
      "Focal aware cognitive seizure with anomia"
    ],
    "gold_answer": "Focal aware seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05838",
    "question": "What phenotype is associated with Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism"
    ],
    "gold_answer": "Thin corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05839",
    "question": "What is associated with Triangular epiphysis of the middle phalanx of the 4th toe?",
    "seeds": [
      "Triangular epiphysis of the middle phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the middle phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05840",
    "question": "What is associated with Lessel-Kubisch syndrome?",
    "seeds": [
      "Lessel-Kubisch syndrome"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05841",
    "question": "What is associated with Bifid sternum?",
    "seeds": [
      "Bifid sternum"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05842",
    "question": "What is associated with Abnormal syntax?",
    "seeds": [
      "Abnormal syntax"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05843",
    "question": "What is associated with Retinitis pigmentosa 49?",
    "seeds": [
      "Retinitis pigmentosa 49"
    ],
    "gold_answer": "Abnormal retinal pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05844",
    "question": "What is associated with Pseudoepiphyses of the toes?",
    "seeds": [
      "Pseudoepiphyses of the toes"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05845",
    "question": "What is associated with Microcephaly, epilepsy, and diabetes syndrome 2?",
    "seeds": [
      "Microcephaly, epilepsy, and diabetes syndrome 2"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05846",
    "question": "What is associated with Elevated imprint of the transverse sinuses?",
    "seeds": [
      "Elevated imprint of the transverse sinuses"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05847",
    "question": "What is associated with Abnormal circulating interleukin 6 concentration?",
    "seeds": [
      "Abnormal circulating interleukin 6 concentration"
    ],
    "gold_answer": "Abnormal immune serum protein physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05848",
    "question": "What is associated with Increased circulating precipitin level?",
    "seeds": [
      "Increased circulating precipitin level"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05849",
    "question": "What phenotype is associated with Developmental delay with variable cardiac and renal congenital anomalies and dysmorphic facies?",
    "seeds": [
      "Developmental delay with variable cardiac and renal congenital anomalies and dysmorphic facies"
    ],
    "gold_answer": "Craniosynostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05850",
    "question": "What is associated with Low serum osmolality?",
    "seeds": [
      "Low serum osmolality"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05851",
    "question": "What is associated with Febrile seizures, familial, 5?",
    "seeds": [
      "Febrile seizures, familial, 5"
    ],
    "gold_answer": "Seizure precipitated by febrile infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05852",
    "question": "What is associated with Embryonal onset?",
    "seeds": [
      "Embryonal onset"
    ],
    "gold_answer": "Onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05853",
    "question": "What is associated with Skin vesicle?",
    "seeds": [
      "Skin vesicle"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05854",
    "question": "What is associated with Broad ulna?",
    "seeds": [
      "Broad ulna"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05855",
    "question": "What is associated with Toe phalanx synostosis?",
    "seeds": [
      "Toe phalanx synostosis"
    ],
    "gold_answer": "Synostosis involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05856",
    "question": "What is associated with Tall lumbar vertebral bodies?",
    "seeds": [
      "Tall lumbar vertebral bodies"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05857",
    "question": "What is associated with Unilateral multifocal epileptiform discharges?",
    "seeds": [
      "Unilateral multifocal epileptiform discharges"
    ],
    "gold_answer": "EEG with focal epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05858",
    "question": "What is associated with Thin proximal phalanges with broad epiphyses of the hand?",
    "seeds": [
      "Thin proximal phalanges with broad epiphyses of the hand"
    ],
    "gold_answer": "Abnormal hand epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05859",
    "question": "What is associated with Increased circulating thyroglobulin concentration?",
    "seeds": [
      "Increased circulating thyroglobulin concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05860",
    "question": "What is associated with Hermansky-Pudlak syndrome due to AP3B1 deficiency?",
    "seeds": [
      "Hermansky-Pudlak syndrome due to AP3B1 deficiency"
    ],
    "gold_answer": "AP3B1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_05861",
    "question": "What is associated with Scapholunate interval widening?",
    "seeds": [
      "Scapholunate interval widening"
    ],
    "gold_answer": "Abnormal wrist morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05862",
    "question": "What is associated with Tufted angioma?",
    "seeds": [
      "Tufted angioma"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05863",
    "question": "What is associated with Lower extremity peripheral arterial calcification?",
    "seeds": [
      "Lower extremity peripheral arterial calcification"
    ],
    "gold_answer": "Arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05864",
    "question": "What is associated with Acetyl-CoA carboxylase deficiency?",
    "seeds": [
      "Acetyl-CoA carboxylase deficiency"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05865",
    "question": "What is associated with Recurrent mycobacterial infections?",
    "seeds": [
      "Recurrent mycobacterial infections"
    ],
    "gold_answer": "Recurrent bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05866",
    "question": "What is associated with Bullet-shaped toe phalanx?",
    "seeds": [
      "Bullet-shaped toe phalanx"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05867",
    "question": "What phenotype is associated with Vitamin D-dependent rickets, type I?",
    "seeds": [
      "Vitamin D-dependent rickets, type I"
    ],
    "gold_answer": "Renal phosphate wasting",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05868",
    "question": "What is associated with Increased cotinine level?",
    "seeds": [
      "Increased cotinine level"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05869",
    "question": "What is associated with Abnormal left ventricular endsystolic diameter?",
    "seeds": [
      "Abnormal left ventricular endsystolic diameter"
    ],
    "gold_answer": "Abnormal cardiac ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05870",
    "question": "What is associated with Fibrous dysplasia of bone?",
    "seeds": [
      "Fibrous dysplasia of bone"
    ],
    "gold_answer": "Abnormality of the ovary",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05871",
    "question": "What is associated with Abnormal brainstem morphology?",
    "seeds": [
      "Abnormal brainstem morphology"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05872",
    "question": "What is associated with Chronic urticaria?",
    "seeds": [
      "Chronic urticaria"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05873",
    "question": "What is associated with Prolonged electroretinal response suppression 1?",
    "seeds": [
      "Prolonged electroretinal response suppression 1"
    ],
    "gold_answer": "RGS9BP",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_05874",
    "question": "What is associated with Hypoplasia of the fallopian tube?",
    "seeds": [
      "Hypoplasia of the fallopian tube"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05875",
    "question": "What phenotype is associated with B-cell expansion with NFKB and T-cell anergy?",
    "seeds": [
      "B-cell expansion with NFKB and T-cell anergy"
    ],
    "gold_answer": "Increased total B cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05876",
    "question": "What is associated with Kayser-Fleischer ring?",
    "seeds": [
      "Kayser-Fleischer ring"
    ],
    "gold_answer": "Corneal opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05877",
    "question": "What is associated with Absent muscle fiber dysferlin?",
    "seeds": [
      "Absent muscle fiber dysferlin"
    ],
    "gold_answer": "Abnormal muscle fiber dysferlin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05878",
    "question": "What is associated with Oocyte maturation defect 5?",
    "seeds": [
      "Oocyte maturation defect 5"
    ],
    "gold_answer": "Infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05879",
    "question": "What is associated with Neurodevelopmental disorder with epilepsy and hemochromatosis?",
    "seeds": [
      "Neurodevelopmental disorder with epilepsy and hemochromatosis"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05880",
    "question": "What is associated with Diaphragmatic hernia 2?",
    "seeds": [
      "Diaphragmatic hernia 2"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05881",
    "question": "What is associated with Late young adult onset?",
    "seeds": [
      "Late young adult onset"
    ],
    "gold_answer": "Onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05882",
    "question": "What is associated with Horizontal opticokinetic nystagmus?",
    "seeds": [
      "Horizontal opticokinetic nystagmus"
    ],
    "gold_answer": "Horizontal nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05883",
    "question": "What phenotype is associated with Myeloproliferative syndrome, transient?",
    "seeds": [
      "Myeloproliferative syndrome, transient"
    ],
    "gold_answer": "Increased total leukocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05884",
    "question": "What is associated with Exacerbated by pulmonary vasodilator exposure?",
    "seeds": [
      "Exacerbated by pulmonary vasodilator exposure"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05885",
    "question": "What is associated with Medial ankle pain?",
    "seeds": [
      "Medial ankle pain"
    ],
    "gold_answer": "Ankle pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05886",
    "question": "What is associated with Chronic hiccup?",
    "seeds": [
      "Chronic hiccup"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05887",
    "question": "What is associated with Dowling-Degos disease 3?",
    "seeds": [
      "Dowling-Degos disease 3"
    ],
    "gold_answer": "Mixed hypo- and hyperpigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05888",
    "question": "What is associated with Amelia involving the lower limbs?",
    "seeds": [
      "Amelia involving the lower limbs"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05889",
    "question": "What is associated with Abnormal epididymis morphology?",
    "seeds": [
      "Abnormal epididymis morphology"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05890",
    "question": "What is associated with Abnormal insertion of umbilical cord?",
    "seeds": [
      "Abnormal insertion of umbilical cord"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05891",
    "question": "What phenotype is associated with Deafness, sensorineural, with peripheral neuropathy and arterial disease?",
    "seeds": [
      "Deafness, sensorineural, with peripheral neuropathy and arterial disease"
    ],
    "gold_answer": "Peripheral arterial stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05892",
    "question": "What phenotype is associated with Oculoectodermal syndrome?",
    "seeds": [
      "Oculoectodermal syndrome"
    ],
    "gold_answer": "Diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05893",
    "question": "What phenotype is associated with Congenital hemidysplasia with ichthyosiform erythroderma and limb defects?",
    "seeds": [
      "Congenital hemidysplasia with ichthyosiform erythroderma and limb defects"
    ],
    "gold_answer": "Single ventricle",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05894",
    "question": "What is associated with Cataract-hypertrichosis-intellectual disability syndrome?",
    "seeds": [
      "Cataract-hypertrichosis-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05895",
    "question": "What phenotype is associated with Neonatal adrenoleukodystrophy?",
    "seeds": [
      "Neonatal adrenoleukodystrophy"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05896",
    "question": "What phenotype is associated with Dyggve-Melchior-Clausen disease?",
    "seeds": [
      "Dyggve-Melchior-Clausen disease"
    ],
    "gold_answer": "Hypoplastic facial bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05897",
    "question": "What is associated with Impaired renal concentrating ability?",
    "seeds": [
      "Impaired renal concentrating ability"
    ],
    "gold_answer": "Renal tubular dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05898",
    "question": "What is associated with Rib fusion?",
    "seeds": [
      "Rib fusion"
    ],
    "gold_answer": "Abnormal rib morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05899",
    "question": "What is associated with Anemia, dyserythropoietic congenital, type II?",
    "seeds": [
      "Anemia, dyserythropoietic congenital, type II"
    ],
    "gold_answer": "Abnormality of the gallbladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05900",
    "question": "What is associated with Cone-Rod dystrophy 18?",
    "seeds": [
      "Cone-Rod dystrophy 18"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05901",
    "question": "What is associated with Abnormal pancreas size?",
    "seeds": [
      "Abnormal pancreas size"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05902",
    "question": "What is associated with Bracket epiphysis of the proximal phalanx of the hallux?",
    "seeds": [
      "Bracket epiphysis of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Bracket epiphyses of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05903",
    "question": "What is associated with Decreased erythrocyte fructose-1,6-bisphosphate aldolase activity?",
    "seeds": [
      "Decreased erythrocyte fructose-1,6-bisphosphate aldolase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05904",
    "question": "What is associated with Time agnosia?",
    "seeds": [
      "Time agnosia"
    ],
    "gold_answer": "Disturbed perception with a stimulus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05905",
    "question": "What is associated with Bleeding requiring red cell transfusion?",
    "seeds": [
      "Bleeding requiring red cell transfusion"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05906",
    "question": "What is associated with Cone-shaped epiphysis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Cone-shaped epiphysis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Phalangeal cone-shaped epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05907",
    "question": "What is associated with Arima syndrome?",
    "seeds": [
      "Arima syndrome"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05908",
    "question": "What is associated with Delayed ossification of the scaphoid?",
    "seeds": [
      "Delayed ossification of the scaphoid"
    ],
    "gold_answer": "Delayed ossification of carpal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05909",
    "question": "What is associated with Renal tubular adenovirus inclusions?",
    "seeds": [
      "Renal tubular adenovirus inclusions"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05910",
    "question": "What is associated with Elevated circulating complement C3 concentration?",
    "seeds": [
      "Elevated circulating complement C3 concentration"
    ],
    "gold_answer": "Elevated circulating complement component concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05911",
    "question": "What is associated with Albinism, oculocutaneous, type V?",
    "seeds": [
      "Albinism, oculocutaneous, type V"
    ],
    "gold_answer": "Generalized hypopigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05912",
    "question": "What is associated with Extensor tendons of finger anomalies?",
    "seeds": [
      "Extensor tendons of finger anomalies"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05913",
    "question": "What is associated with Blepharophimosis-impaired intellectual development syndrome?",
    "seeds": [
      "Blepharophimosis-impaired intellectual development syndrome"
    ],
    "gold_answer": "Abnormal toenail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05914",
    "question": "What is associated with Hereditary sick sinus syndrome?",
    "seeds": [
      "Hereditary sick sinus syndrome"
    ],
    "gold_answer": "HCN4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_05915",
    "question": "What is associated with Endocardial fibroelastosis?",
    "seeds": [
      "Endocardial fibroelastosis"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05916",
    "question": "What is associated with Weak anal sphincter tone?",
    "seeds": [
      "Weak anal sphincter tone"
    ],
    "gold_answer": "Abnormality of the anus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05917",
    "question": "What is associated with Broad middle phalanx of the 5th toe?",
    "seeds": [
      "Broad middle phalanx of the 5th toe"
    ],
    "gold_answer": "Broad phalanx of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05918",
    "question": "What is associated with Currarino syndrome?",
    "seeds": [
      "Currarino syndrome"
    ],
    "gold_answer": "Abnormal anus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05919",
    "question": "What is associated with Decreased mannosylation of N-linked protein glycosylation?",
    "seeds": [
      "Decreased mannosylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05920",
    "question": "What is associated with Hypoplasia of the semicircular canal?",
    "seeds": [
      "Hypoplasia of the semicircular canal"
    ],
    "gold_answer": "Abnormal semicircular canal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05921",
    "question": "What is associated with Decreased circulating antimullerian hormone circulation?",
    "seeds": [
      "Decreased circulating antimullerian hormone circulation"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05922",
    "question": "What is associated with Lymphatic malformation 14?",
    "seeds": [
      "Lymphatic malformation 14"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05923",
    "question": "What is associated with Crackles?",
    "seeds": [
      "Crackles"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05924",
    "question": "What is associated with Fumarase deficiency?",
    "seeds": [
      "Fumarase deficiency"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05925",
    "question": "What is associated with Exercise-induced myoglobinuria?",
    "seeds": [
      "Exercise-induced myoglobinuria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05926",
    "question": "What is associated with Fractured coccyx?",
    "seeds": [
      "Fractured coccyx"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05927",
    "question": "What is associated with Abnormal fundus autofluorescence imaging?",
    "seeds": [
      "Abnormal fundus autofluorescence imaging"
    ],
    "gold_answer": "Abnormal posterior segment imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05928",
    "question": "What is associated with Phakomatosis pigmentokeratotica?",
    "seeds": [
      "Phakomatosis pigmentokeratotica"
    ],
    "gold_answer": "Sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05929",
    "question": "What is associated with Cervical C2/C3 vertebral fusion?",
    "seeds": [
      "Cervical C2/C3 vertebral fusion"
    ],
    "gold_answer": "Vertebral fusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05930",
    "question": "What is associated with Elevated urinary thymidine level?",
    "seeds": [
      "Elevated urinary thymidine level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05931",
    "question": "What phenotype is associated with Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies?",
    "seeds": [
      "Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies"
    ],
    "gold_answer": "Thickening of the glomerular basement membrane",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05932",
    "question": "What is associated with Increased urine glutamate level?",
    "seeds": [
      "Increased urine glutamate level"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05933",
    "question": "What is associated with Ring chromosome 22 syndrome?",
    "seeds": [
      "Ring chromosome 22 syndrome"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05934",
    "question": "What is associated with Positive meconium methadone test?",
    "seeds": [
      "Positive meconium methadone test"
    ],
    "gold_answer": "Meconium xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05935",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 1?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 1"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05936",
    "question": "What is associated with Cortical radial artery hypercellularity?",
    "seeds": [
      "Cortical radial artery hypercellularity"
    ],
    "gold_answer": "Abnormal intrarenal artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05937",
    "question": "What phenotype is associated with Li-Fraumeni syndrome 2?",
    "seeds": [
      "Li-Fraumeni syndrome 2"
    ],
    "gold_answer": "Vascular tortuosity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05938",
    "question": "What is associated with Abnormal emotional state?",
    "seeds": [
      "Abnormal emotional state"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05939",
    "question": "What phenotype is associated with Amniotic band syndrome?",
    "seeds": [
      "Amniotic band syndrome"
    ],
    "gold_answer": "Hydrocephalus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05940",
    "question": "What is associated with Abnormal mandible morphology?",
    "seeds": [
      "Abnormal mandible morphology"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05941",
    "question": "What is associated with Hypoplasia of the prostate?",
    "seeds": [
      "Hypoplasia of the prostate"
    ],
    "gold_answer": "Abnormal male internal genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05942",
    "question": "What is associated with Absent bronchoalveolar surfactant-protein C?",
    "seeds": [
      "Absent bronchoalveolar surfactant-protein C"
    ],
    "gold_answer": "Abnormal bronchoalveolar fluid protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05943",
    "question": "What is associated with Abnormal genital pigmentation?",
    "seeds": [
      "Abnormal genital pigmentation"
    ],
    "gold_answer": "Abnormal external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05944",
    "question": "What is associated with Glycosylphosphatidylinositol deficiency?",
    "seeds": [
      "Glycosylphosphatidylinositol deficiency"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05945",
    "question": "What is associated with Abnormal multifocal electroretinogram?",
    "seeds": [
      "Abnormal multifocal electroretinogram"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05946",
    "question": "What is associated with Pseudoxanthoma elasticum, forme fruste?",
    "seeds": [
      "Pseudoxanthoma elasticum, forme fruste"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05947",
    "question": "What is associated with Elevated urinary mevalonate lactone level?",
    "seeds": [
      "Elevated urinary mevalonate lactone level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05948",
    "question": "What is associated with Decreased myocardial glycogen content?",
    "seeds": [
      "Decreased myocardial glycogen content"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05949",
    "question": "What is associated with Fusion of gums?",
    "seeds": [
      "Fusion of gums"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05950",
    "question": "What is associated with Mosaic trisomy 12 syndrome?",
    "seeds": [
      "Mosaic trisomy 12 syndrome"
    ],
    "gold_answer": "Abnormality of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05951",
    "question": "What phenotype is associated with Retinitis pigmentosa 27?",
    "seeds": [
      "Retinitis pigmentosa 27"
    ],
    "gold_answer": "Rod-cone dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05952",
    "question": "What is associated with Cerebral venous sinus thrombosis?",
    "seeds": [
      "Cerebral venous sinus thrombosis"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05953",
    "question": "What is associated with Atrophoderma vermiculata?",
    "seeds": [
      "Atrophoderma vermiculata"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05954",
    "question": "What is associated with Lymph-node follicular sclerosis?",
    "seeds": [
      "Lymph-node follicular sclerosis"
    ],
    "gold_answer": "Abnormal lymph-node biospecimen",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05955",
    "question": "What is associated with Cervical vertebral agenesis?",
    "seeds": [
      "Cervical vertebral agenesis"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05956",
    "question": "What is associated with Renal amyloidosis?",
    "seeds": [
      "Renal amyloidosis"
    ],
    "gold_answer": "Amyloid deposition by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05957",
    "question": "What is associated with Interlobular septal thickening?",
    "seeds": [
      "Interlobular septal thickening"
    ],
    "gold_answer": "Pulmonary interstitial high-resolution computed tomography abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05958",
    "question": "What is associated with Thymic cyst?",
    "seeds": [
      "Thymic cyst"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05959",
    "question": "What is associated with Fusion of the caudate and putamen?",
    "seeds": [
      "Fusion of the caudate and putamen"
    ],
    "gold_answer": "Abnormal basal ganglia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05960",
    "question": "What is associated with 5q35 microduplication syndrome?",
    "seeds": [
      "5q35 microduplication syndrome"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05961",
    "question": "What is associated with Atrial septal defect 8?",
    "seeds": [
      "Atrial septal defect 8"
    ],
    "gold_answer": "Abnormal atrial septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05962",
    "question": "What is associated with Rubinstein-Taybi syndrome?",
    "seeds": [
      "Rubinstein-Taybi syndrome"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05963",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 19?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 19"
    ],
    "gold_answer": "Elevated circulating hepatic transaminase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05964",
    "question": "What is associated with Chorioretinal dystrophy?",
    "seeds": [
      "Chorioretinal dystrophy"
    ],
    "gold_answer": "Abnormal uvea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05965",
    "question": "What phenotype is associated with Autosomal spastic paraplegia type 58?",
    "seeds": [
      "Autosomal spastic paraplegia type 58"
    ],
    "gold_answer": "Peripheral demyelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05966",
    "question": "What is associated with Fibrosis of extraocular muscles, congenital, 3A, with or without extraocularinvolvement?",
    "seeds": [
      "Fibrosis of extraocular muscles, congenital, 3A, with or without extraocularinvolvement"
    ],
    "gold_answer": "Compensatory head posture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05967",
    "question": "What is associated with Macular dystrophy, patterned, 3?",
    "seeds": [
      "Macular dystrophy, patterned, 3"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05968",
    "question": "What is associated with Elevated fraction exhaled nitric oxide?",
    "seeds": [
      "Elevated fraction exhaled nitric oxide"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05969",
    "question": "What is associated with Intramuscular lipoma?",
    "seeds": [
      "Intramuscular lipoma"
    ],
    "gold_answer": "Lipoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05970",
    "question": "What phenotype is associated with Fusariosis?",
    "seeds": [
      "Fusariosis"
    ],
    "gold_answer": "Hypersensitivity pneumonitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05971",
    "question": "What is associated with Hypoplasia of the semicircular canal?",
    "seeds": [
      "Hypoplasia of the semicircular canal"
    ],
    "gold_answer": "Abnormal morphology of the vestibule of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05972",
    "question": "What is associated with Focal aware cognitive seizure with anomia?",
    "seeds": [
      "Focal aware cognitive seizure with anomia"
    ],
    "gold_answer": "Focal aware cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05973",
    "question": "What is associated with Lethal congenital contracture syndrome 4?",
    "seeds": [
      "Lethal congenital contracture syndrome 4"
    ],
    "gold_answer": "Congenital contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05974",
    "question": "What is associated with Anti-GT1a IgM antibody positivity?",
    "seeds": [
      "Anti-GT1a IgM antibody positivity"
    ],
    "gold_answer": "Anti-ganglioside antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05975",
    "question": "What is associated with Gonadal dysgenesis with female appearance, male?",
    "seeds": [
      "Gonadal dysgenesis with female appearance, male"
    ],
    "gold_answer": "Gonadal dysgenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05976",
    "question": "What is associated with Harel-Yoon syndrome?",
    "seeds": [
      "Harel-Yoon syndrome"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05977",
    "question": "What is associated with 5-oxoprolinase deficiency?",
    "seeds": [
      "5-oxoprolinase deficiency"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05978",
    "question": "What is associated with Phenobarbital embryopathy?",
    "seeds": [
      "Phenobarbital embryopathy"
    ],
    "gold_answer": "GATA4",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_05979",
    "question": "What is associated with Hypotrichosis and recurrent skin vesicles?",
    "seeds": [
      "Hypotrichosis and recurrent skin vesicles"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05980",
    "question": "What is associated with Onychogryphosis?",
    "seeds": [
      "Onychogryphosis"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05981",
    "question": "What is associated with Rhizomelic dysplasia, Patterson-Lowry type?",
    "seeds": [
      "Rhizomelic dysplasia, Patterson-Lowry type"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05982",
    "question": "What phenotype is associated with Perioral myoclonia with absences?",
    "seeds": [
      "Perioral myoclonia with absences"
    ],
    "gold_answer": "Chin myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05983",
    "question": "What is associated with Periodic fever, menstrual cycle-dependent?",
    "seeds": [
      "Periodic fever, menstrual cycle-dependent"
    ],
    "gold_answer": "Headache",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05984",
    "question": "What phenotype is associated with Macular dystrophy, vitelliform, 4?",
    "seeds": [
      "Macular dystrophy, vitelliform, 4"
    ],
    "gold_answer": "Moderately reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05985",
    "question": "What is associated with Impaired arachidonic acid-induced platelet aggregation?",
    "seeds": [
      "Impaired arachidonic acid-induced platelet aggregation"
    ],
    "gold_answer": "Impaired platelet aggregation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05986",
    "question": "What is associated with Duplication of phalanx of 2nd finger?",
    "seeds": [
      "Duplication of phalanx of 2nd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05987",
    "question": "What is associated with Increased KCO?",
    "seeds": [
      "Increased KCO"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05988",
    "question": "What is associated with Sugarman brachydactyly?",
    "seeds": [
      "Sugarman brachydactyly"
    ],
    "gold_answer": "Proximal symphalangism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05989",
    "question": "What phenotype is associated with Short stature, auditory canal atresia, mandibular hypoplasia, andskeletal abnormalities?",
    "seeds": [
      "Short stature, auditory canal atresia, mandibular hypoplasia, andskeletal abnormalities"
    ],
    "gold_answer": "Flared metaphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05990",
    "question": "What phenotype is associated with Severe intellectual disability-progressive postnatal microcephaly-midline stereotypic hand movements syndrome?",
    "seeds": [
      "Severe intellectual disability-progressive postnatal microcephaly-midline stereotypic hand movements syndrome"
    ],
    "gold_answer": "Progressive microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05991",
    "question": "What is associated with Shock?",
    "seeds": [
      "Shock"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05992",
    "question": "What is associated with Familial hypocalciuric hypercalcemia?",
    "seeds": [
      "Familial hypocalciuric hypercalcemia"
    ],
    "gold_answer": "Episodic pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05993",
    "question": "What is associated with Constricted radial neck?",
    "seeds": [
      "Constricted radial neck"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05994",
    "question": "What is associated with Joubert syndrome 23?",
    "seeds": [
      "Joubert syndrome 23"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05995",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 61?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 61"
    ],
    "gold_answer": "Disinhibition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05996",
    "question": "What is associated with Diffuse swelling of cerebral white matter?",
    "seeds": [
      "Diffuse swelling of cerebral white matter"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05997",
    "question": "What phenotype is associated with Syndromic multisystem autoimmune disease due to Itch deficiency?",
    "seeds": [
      "Syndromic multisystem autoimmune disease due to Itch deficiency"
    ],
    "gold_answer": "Dolichocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_05998",
    "question": "What is associated with Camptodactyly-tall stature-scoliosis-hearing loss syndrome?",
    "seeds": [
      "Camptodactyly-tall stature-scoliosis-hearing loss syndrome"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_05999",
    "question": "What is associated with Silent hypoxemia?",
    "seeds": [
      "Silent hypoxemia"
    ],
    "gold_answer": "Hypoxemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06000",
    "question": "What is associated with Elevated hemoglobin A1c?",
    "seeds": [
      "Elevated hemoglobin A1c"
    ],
    "gold_answer": "Abnormal hemoglobin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06001",
    "question": "What phenotype is associated with Paget disease of bone 5, juvenile-onset?",
    "seeds": [
      "Paget disease of bone 5, juvenile-onset"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06002",
    "question": "What is associated with Unaided visual acuity 0.7 LogMAR?",
    "seeds": [
      "Unaided visual acuity 0.7 LogMAR"
    ],
    "gold_answer": "Abnormal unaided visual acuity test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06003",
    "question": "What is associated with Gerstmann-Straussler-Scheinker syndrome?",
    "seeds": [
      "Gerstmann-Straussler-Scheinker syndrome"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06004",
    "question": "What is associated with Ascending aortic dissection?",
    "seeds": [
      "Ascending aortic dissection"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06005",
    "question": "What is associated with Thymic carcinoid tumor?",
    "seeds": [
      "Thymic carcinoid tumor"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06006",
    "question": "What is associated with Monosomy 7 myelodysplasia and leukemia syndrome 2?",
    "seeds": [
      "Monosomy 7 myelodysplasia and leukemia syndrome 2"
    ],
    "gold_answer": "Abnormal bone marrow cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06007",
    "question": "What is associated with Inferior oblique muscle overaction?",
    "seeds": [
      "Inferior oblique muscle overaction"
    ],
    "gold_answer": "Abnormal extraocular muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06008",
    "question": "What phenotype is associated with Cyanide-induced parkinsonism-dystonia?",
    "seeds": [
      "Cyanide-induced parkinsonism-dystonia"
    ],
    "gold_answer": "Dysarthria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06009",
    "question": "What phenotype is associated with Thumbs, stiff, with brachydactyly type A1 and developmental delay?",
    "seeds": [
      "Thumbs, stiff, with brachydactyly type A1 and developmental delay"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06010",
    "question": "What is associated with Esophoria?",
    "seeds": [
      "Esophoria"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06011",
    "question": "What is associated with Neural tube defect?",
    "seeds": [
      "Neural tube defect"
    ],
    "gold_answer": "Abnormal neural tube morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06012",
    "question": "What is associated with Subretinal hyporeflective spaces on macular OCT?",
    "seeds": [
      "Subretinal hyporeflective spaces on macular OCT"
    ],
    "gold_answer": "Abnormal retinal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06013",
    "question": "What phenotype is associated with Acquired hypertrichosis lanuginosa?",
    "seeds": [
      "Acquired hypertrichosis lanuginosa"
    ],
    "gold_answer": "Acanthosis nigricans",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06014",
    "question": "What phenotype is associated with Brachydactyly-syndactyly, Zhao type?",
    "seeds": [
      "Brachydactyly-syndactyly, Zhao type"
    ],
    "gold_answer": "Hallux valgus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06015",
    "question": "What phenotype is associated with Infant botulism?",
    "seeds": [
      "Infant botulism"
    ],
    "gold_answer": "Constipation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06016",
    "question": "What is associated with Glomerular endocapillary hypercellularity?",
    "seeds": [
      "Glomerular endocapillary hypercellularity"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06017",
    "question": "What is associated with Renal duplication?",
    "seeds": [
      "Renal duplication"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06018",
    "question": "What is associated with Intrauterine growth retardation with increased mitomycin C sensitivity?",
    "seeds": [
      "Intrauterine growth retardation with increased mitomycin C sensitivity"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06019",
    "question": "What is associated with Overlapping fingers?",
    "seeds": [
      "Overlapping fingers"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06020",
    "question": "What is associated with Abnormal morphology of the radius?",
    "seeds": [
      "Abnormal morphology of the radius"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06021",
    "question": "What is associated with Hyperphalangy of the 2nd finger?",
    "seeds": [
      "Hyperphalangy of the 2nd finger"
    ],
    "gold_answer": "Finger hyperphalangy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06022",
    "question": "What is associated with Microcoria?",
    "seeds": [
      "Microcoria"
    ],
    "gold_answer": "Abnormal pupil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06023",
    "question": "What is associated with Extraskeletal Ewing sarcoma?",
    "seeds": [
      "Extraskeletal Ewing sarcoma"
    ],
    "gold_answer": "ERG",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_06024",
    "question": "What is associated with Abnormal spermatogenesis?",
    "seeds": [
      "Abnormal spermatogenesis"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06025",
    "question": "What is associated with Familial paroxysmal ataxia?",
    "seeds": [
      "Familial paroxysmal ataxia"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06026",
    "question": "What is associated with Pain at the posterior aspect of the elbow?",
    "seeds": [
      "Pain at the posterior aspect of the elbow"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06027",
    "question": "What is associated with Oligosacchariduria?",
    "seeds": [
      "Oligosacchariduria"
    ],
    "gold_answer": "Abnormal urine carbohydrate level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06028",
    "question": "What is associated with Hypoplasia of fetal nasal bone?",
    "seeds": [
      "Hypoplasia of fetal nasal bone"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06029",
    "question": "What is associated with Abnormal pattern electroretinogram?",
    "seeds": [
      "Abnormal pattern electroretinogram"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06030",
    "question": "What is associated with Triangular shaped proximal phalanx of the hallux?",
    "seeds": [
      "Triangular shaped proximal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06031",
    "question": "What is associated with Ectodermal dysplasia 13, Hair/tooth type?",
    "seeds": [
      "Ectodermal dysplasia 13, Hair/tooth type"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06032",
    "question": "What phenotype is associated with Fibrous cardiac diverticulum?",
    "seeds": [
      "Fibrous cardiac diverticulum"
    ],
    "gold_answer": "Coronaryartery atherosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06033",
    "question": "What phenotype is associated with Card11 immunodeficiency?",
    "seeds": [
      "Card11 immunodeficiency"
    ],
    "gold_answer": "Pneumocystis jirovecii pneumonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06034",
    "question": "What is associated with Familial scaphocephaly syndrome, McGillivray type?",
    "seeds": [
      "Familial scaphocephaly syndrome, McGillivray type"
    ],
    "gold_answer": "Abnormal cerebral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06035",
    "question": "What is associated with Anomalous origin of left coronary artery from the pulmonary artery?",
    "seeds": [
      "Anomalous origin of left coronary artery from the pulmonary artery"
    ],
    "gold_answer": "Abnormal coronary artery origin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06036",
    "question": "What is associated with Increased circulating nicotinurate level?",
    "seeds": [
      "Increased circulating nicotinurate level"
    ],
    "gold_answer": "Abnormal circulating nicotinurate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06037",
    "question": "What is associated with Short stature-craniofacial anomalies-genital hypoplasia syndrome?",
    "seeds": [
      "Short stature-craniofacial anomalies-genital hypoplasia syndrome"
    ],
    "gold_answer": "Abnormal neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06038",
    "question": "What is associated with Disordered steroidogenesis due to cytochrome P450 oxidoreductase?",
    "seeds": [
      "Disordered steroidogenesis due to cytochrome P450 oxidoreductase"
    ],
    "gold_answer": "Abnormal circulating adrenocorticotropin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06039",
    "question": "What phenotype is associated with Holoprosencephaly with fetal akinesia/hypokinesia sequence?",
    "seeds": [
      "Holoprosencephaly with fetal akinesia/hypokinesia sequence"
    ],
    "gold_answer": "Macrotia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06040",
    "question": "What is associated with Tzanck smear with multinucleated giant cells?",
    "seeds": [
      "Tzanck smear with multinucleated giant cells"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06041",
    "question": "What is associated with Anti-acetylcholine receptor antibody positivity?",
    "seeds": [
      "Anti-acetylcholine receptor antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06042",
    "question": "What phenotype is associated with Kleefstra syndrome 2?",
    "seeds": [
      "Kleefstra syndrome 2"
    ],
    "gold_answer": "Nasal, dysarthic speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06043",
    "question": "What is associated with Decreased tear drainage?",
    "seeds": [
      "Decreased tear drainage"
    ],
    "gold_answer": "Epiphora",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06044",
    "question": "What is associated with Bladder trabeculation?",
    "seeds": [
      "Bladder trabeculation"
    ],
    "gold_answer": "Abnormal bladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06045",
    "question": "What is associated with Hypersensitivity pneumonitis?",
    "seeds": [
      "Hypersensitivity pneumonitis"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06046",
    "question": "What is associated with Hao-Fountain syndrome due to USP7 mutation?",
    "seeds": [
      "Hao-Fountain syndrome due to USP7 mutation"
    ],
    "gold_answer": "USP7",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06047",
    "question": "What is associated with Abnormal urine urobilinogen level?",
    "seeds": [
      "Abnormal urine urobilinogen level"
    ],
    "gold_answer": "Abnormal urinary organic compound level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06048",
    "question": "What is associated with Hypoplastic nipples?",
    "seeds": [
      "Hypoplastic nipples"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the nipples",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06049",
    "question": "What is associated with Abnormal antihelix morphology?",
    "seeds": [
      "Abnormal antihelix morphology"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06050",
    "question": "What is associated with Female pseudohermaphroditism?",
    "seeds": [
      "Female pseudohermaphroditism"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06051",
    "question": "What is associated with Abnormal mitral valve physiology?",
    "seeds": [
      "Abnormal mitral valve physiology"
    ],
    "gold_answer": "Abnormal heart valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06052",
    "question": "What is associated with Lower-limb metaphyseal irregularity?",
    "seeds": [
      "Lower-limb metaphyseal irregularity"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06053",
    "question": "What is associated with Epithelioid hemangioma?",
    "seeds": [
      "Epithelioid hemangioma"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06054",
    "question": "What is associated with Sebaceous gland hyperplasia, familial presenile?",
    "seeds": [
      "Sebaceous gland hyperplasia, familial presenile"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06055",
    "question": "What is associated with Lymphoproliferative disorder?",
    "seeds": [
      "Lymphoproliferative disorder"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06056",
    "question": "What is associated with Osteolytic defects of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Osteolytic defects of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06057",
    "question": "What is associated with Absent thumb?",
    "seeds": [
      "Absent thumb"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06058",
    "question": "What is associated with Distal myopathy, Welander type?",
    "seeds": [
      "Distal myopathy, Welander type"
    ],
    "gold_answer": "Abnormality of the musculature of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06059",
    "question": "What is associated with Left bundle branch block?",
    "seeds": [
      "Left bundle branch block"
    ],
    "gold_answer": "Cardiac conduction abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06060",
    "question": "What is associated with Aerophagia?",
    "seeds": [
      "Aerophagia"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06061",
    "question": "What is associated with Dicarboxylic aminoaciduria?",
    "seeds": [
      "Dicarboxylic aminoaciduria"
    ],
    "gold_answer": "SLC1A1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_06062",
    "question": "What is associated with Primary angiitis of the central nervous system?",
    "seeds": [
      "Primary angiitis of the central nervous system"
    ],
    "gold_answer": "Internal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06063",
    "question": "What is associated with Epilepsy with myoclonic-atonic seizures?",
    "seeds": [
      "Epilepsy with myoclonic-atonic seizures"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06064",
    "question": "What is associated with Heparan sulfate excretion in urine?",
    "seeds": [
      "Heparan sulfate excretion in urine"
    ],
    "gold_answer": "Mucopolysacchariduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06065",
    "question": "What is associated with Sclerotic foci of metaphyses of the elbow?",
    "seeds": [
      "Sclerotic foci of metaphyses of the elbow"
    ],
    "gold_answer": "Sclerosis of metaphyses of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06066",
    "question": "What phenotype is associated with Kleeblattschaedel syndrome?",
    "seeds": [
      "Kleeblattschaedel syndrome"
    ],
    "gold_answer": "Craniosynostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06067",
    "question": "What is associated with Ruminations?",
    "seeds": [
      "Ruminations"
    ],
    "gold_answer": "Abnormal preoccupation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06068",
    "question": "What is associated with Teebi hypertelorism syndrome 2?",
    "seeds": [
      "Teebi hypertelorism syndrome 2"
    ],
    "gold_answer": "Abnormal upper lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06069",
    "question": "What is associated with Hermansky-Pudlak syndrome 1?",
    "seeds": [
      "Hermansky-Pudlak syndrome 1"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06070",
    "question": "What is associated with Neutrophilic urticarial dermatosis?",
    "seeds": [
      "Neutrophilic urticarial dermatosis"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06071",
    "question": "What phenotype is associated with Peutz-Jeghers syndrome?",
    "seeds": [
      "Peutz-Jeghers syndrome"
    ],
    "gold_answer": "Uterine neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06072",
    "question": "What is associated with Brachydactyly-arterial hypertension syndrome?",
    "seeds": [
      "Brachydactyly-arterial hypertension syndrome"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06073",
    "question": "What phenotype is associated with Encephalopathy, progressive, early-onset, with episodic rhabdomyolysis?",
    "seeds": [
      "Encephalopathy, progressive, early-onset, with episodic rhabdomyolysis"
    ],
    "gold_answer": "Tetraplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06074",
    "question": "What is associated with Epidermolysis bullosa dystrophica neurotrophica?",
    "seeds": [
      "Epidermolysis bullosa dystrophica neurotrophica"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06075",
    "question": "What is associated with Temple syndrome due to paternal 14q32.2 hypomethylation?",
    "seeds": [
      "Temple syndrome due to paternal 14q32.2 hypomethylation"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06076",
    "question": "What is associated with IgG4-related dacryoadenitis and sialadenitis?",
    "seeds": [
      "IgG4-related dacryoadenitis and sialadenitis"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06077",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 18?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 18"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06078",
    "question": "What is associated with Increased CSF urate concentration?",
    "seeds": [
      "Increased CSF urate concentration"
    ],
    "gold_answer": "Abnormal CSF urate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06079",
    "question": "What is associated with Neurofibromatosis, familial spinal?",
    "seeds": [
      "Neurofibromatosis, familial spinal"
    ],
    "gold_answer": "Neoplasm of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06080",
    "question": "What is associated with Mandibulofacial dysostosis with ptosis, autosomal dominant?",
    "seeds": [
      "Mandibulofacial dysostosis with ptosis, autosomal dominant"
    ],
    "gold_answer": "Tooth malposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06081",
    "question": "What is associated with Abnormal spinal cord dorsal column morphology?",
    "seeds": [
      "Abnormal spinal cord dorsal column morphology"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06082",
    "question": "What is associated with Myopathy, centronuclear, 2?",
    "seeds": [
      "Myopathy, centronuclear, 2"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06083",
    "question": "What is associated with Marginal umbilical cord insertion?",
    "seeds": [
      "Marginal umbilical cord insertion"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06084",
    "question": "What is associated with Coronary sinus diverticulum?",
    "seeds": [
      "Coronary sinus diverticulum"
    ],
    "gold_answer": "Abnormal coronary sinus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06085",
    "question": "What phenotype is associated with Robinow syndrome?",
    "seeds": [
      "Robinow syndrome"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06086",
    "question": "What is associated with Recurrent parasitic infections?",
    "seeds": [
      "Recurrent parasitic infections"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06087",
    "question": "What is associated with High altitude exposure?",
    "seeds": [
      "High altitude exposure"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06088",
    "question": "What phenotype is associated with Camptomelic syndrome, Long-Limb type?",
    "seeds": [
      "Camptomelic syndrome, Long-Limb type"
    ],
    "gold_answer": "Bowing of the long bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06089",
    "question": "What phenotype is associated with Growth hormone deficiency, isolated, type IV?",
    "seeds": [
      "Growth hormone deficiency, isolated, type IV"
    ],
    "gold_answer": "Severe short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06090",
    "question": "What is associated with Second trimester onset?",
    "seeds": [
      "Second trimester onset"
    ],
    "gold_answer": "Onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06091",
    "question": "What is associated with Talonavicular coalition?",
    "seeds": [
      "Talonavicular coalition"
    ],
    "gold_answer": "Absent toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06092",
    "question": "What is associated with Ocular cystine crystal deposition?",
    "seeds": [
      "Ocular cystine crystal deposition"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06093",
    "question": "What phenotype is associated with Cataract 49?",
    "seeds": [
      "Cataract 49"
    ],
    "gold_answer": "Posterior cortical cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06094",
    "question": "What is associated with Medium chain acyl-CoA dehydrogenase deficiency?",
    "seeds": [
      "Medium chain acyl-CoA dehydrogenase deficiency"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06095",
    "question": "What phenotype is associated with TELO2-related intellectual disability-neurodevelopmental disorder?",
    "seeds": [
      "TELO2-related intellectual disability-neurodevelopmental disorder"
    ],
    "gold_answer": "Joint hypermobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06096",
    "question": "What is associated with Sclerosis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Sclerosis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Sclerosis of 3rd finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06097",
    "question": "What is associated with Hypomagnesemia?",
    "seeds": [
      "Hypomagnesemia"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06098",
    "question": "What is associated with Erythrokeratodermia variabilis et progressiva 3?",
    "seeds": [
      "Erythrokeratodermia variabilis et progressiva 3"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06099",
    "question": "What is associated with Patchy changes of bone mineral density?",
    "seeds": [
      "Patchy changes of bone mineral density"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06100",
    "question": "What is associated with Gonadal dysgenesis, male?",
    "seeds": [
      "Gonadal dysgenesis, male"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06101",
    "question": "What is associated with Familial cold autoinflammatory syndrome 4?",
    "seeds": [
      "Familial cold autoinflammatory syndrome 4"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06102",
    "question": "What is associated with Erythrokeratodermia variabilis et progressiva 4?",
    "seeds": [
      "Erythrokeratodermia variabilis et progressiva 4"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06103",
    "question": "What phenotype is associated with X-linked intellectual disability-acromegaly-hyperactivity syndrome?",
    "seeds": [
      "X-linked intellectual disability-acromegaly-hyperactivity syndrome"
    ],
    "gold_answer": "Folate-dependent fragile site at Xq28",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06104",
    "question": "What is associated with Pseudoepiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Pseudoepiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06105",
    "question": "What phenotype is associated with Salla disease?",
    "seeds": [
      "Salla disease"
    ],
    "gold_answer": "Exotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06106",
    "question": "What is associated with Intellectual developmental disorder, X-linked 73?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 73"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06107",
    "question": "What is associated with Intestinal worm?",
    "seeds": [
      "Intestinal worm"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06108",
    "question": "What is associated with Shoulder subluxation?",
    "seeds": [
      "Shoulder subluxation"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06109",
    "question": "What is associated with Isolated absence of upper arm and forearm with hand present?",
    "seeds": [
      "Isolated absence of upper arm and forearm with hand present"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06110",
    "question": "What is associated with Fractured distal phalanx of manual digit 5?",
    "seeds": [
      "Fractured distal phalanx of manual digit 5"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06111",
    "question": "What is associated with Recurrent viral skin infections?",
    "seeds": [
      "Recurrent viral skin infections"
    ],
    "gold_answer": "Recurrent viral infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06112",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 43?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 43"
    ],
    "gold_answer": "Knee flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06113",
    "question": "What is associated with Agenesis of permanent mandibular central incisor?",
    "seeds": [
      "Agenesis of permanent mandibular central incisor"
    ],
    "gold_answer": "Agenesis of mandibular central incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06114",
    "question": "What is associated with 5p13 microduplication syndrome?",
    "seeds": [
      "5p13 microduplication syndrome"
    ],
    "gold_answer": "NIPBL",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "role_in_the_phenotype_of"
    }
  },
  {
    "query_id": "orph_train_06115",
    "question": "What is associated with Osseous finger syndactyly?",
    "seeds": [
      "Osseous finger syndactyly"
    ],
    "gold_answer": "Finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06116",
    "question": "What is associated with Posterior fusion of lumbosacral vertebrae?",
    "seeds": [
      "Posterior fusion of lumbosacral vertebrae"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06117",
    "question": "What is associated with Pterygium colli-intellectual disability-digital anomalies syndrome?",
    "seeds": [
      "Pterygium colli-intellectual disability-digital anomalies syndrome"
    ],
    "gold_answer": "Enlarged joints",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06118",
    "question": "What is associated with Oculogastrointestinal neurodevelopmental syndrome?",
    "seeds": [
      "Oculogastrointestinal neurodevelopmental syndrome"
    ],
    "gold_answer": "Abnormality of the anus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06119",
    "question": "What phenotype is associated with Woolly hair-skin fragility syndrome?",
    "seeds": [
      "Woolly hair-skin fragility syndrome"
    ],
    "gold_answer": "Slow-growing hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06120",
    "question": "What is associated with Ivory epiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Ivory epiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Sclerosis of 4th finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06121",
    "question": "What is associated with Delayed elbow epiphyseal ossification?",
    "seeds": [
      "Delayed elbow epiphyseal ossification"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06122",
    "question": "What is associated with Pharyngeal exudate?",
    "seeds": [
      "Pharyngeal exudate"
    ],
    "gold_answer": "Abnormal pharynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06123",
    "question": "What is associated with Abnormal lymph-node lymphoctye nuclear morphology?",
    "seeds": [
      "Abnormal lymph-node lymphoctye nuclear morphology"
    ],
    "gold_answer": "Abnormal lymph-node cellular finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06124",
    "question": "What is associated with ALG11-CDG?",
    "seeds": [
      "ALG11-CDG"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06125",
    "question": "What is associated with Small trapezoid bone?",
    "seeds": [
      "Small trapezoid bone"
    ],
    "gold_answer": "Abnormal wrist morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06126",
    "question": "What phenotype is associated with Elliptocytosis 2?",
    "seeds": [
      "Elliptocytosis 2"
    ],
    "gold_answer": "Reticulocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06127",
    "question": "What is associated with Asternia?",
    "seeds": [
      "Asternia"
    ],
    "gold_answer": "Abnormal sternum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06128",
    "question": "What is associated with Aggravated by sun exposure?",
    "seeds": [
      "Aggravated by sun exposure"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06129",
    "question": "What is associated with Long eyelashes?",
    "seeds": [
      "Long eyelashes"
    ],
    "gold_answer": "Abnormal eyelash morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06130",
    "question": "What phenotype is associated with Premature aging syndrome, Penttinen type?",
    "seeds": [
      "Premature aging syndrome, Penttinen type"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06131",
    "question": "What is associated with Horner syndrome?",
    "seeds": [
      "Horner syndrome"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06132",
    "question": "What is associated with Noonan syndrome-like disorder with loose anagen hair?",
    "seeds": [
      "Noonan syndrome-like disorder with loose anagen hair"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06133",
    "question": "What is associated with Enlarged posterior fossa?",
    "seeds": [
      "Enlarged posterior fossa"
    ],
    "gold_answer": "Abnormal skull base morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06134",
    "question": "What is associated with Abnormal palmar dermal ridges?",
    "seeds": [
      "Abnormal palmar dermal ridges"
    ],
    "gold_answer": "Abnormal palm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06135",
    "question": "What is associated with Beemer-Ertbruggen syndrome?",
    "seeds": [
      "Beemer-Ertbruggen syndrome"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06136",
    "question": "What is associated with Asynergia?",
    "seeds": [
      "Asynergia"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06137",
    "question": "What is associated with Type 2 schizencephaly?",
    "seeds": [
      "Type 2 schizencephaly"
    ],
    "gold_answer": "Hemiplegia/hemiparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06138",
    "question": "What is associated with Myelocystocele?",
    "seeds": [
      "Myelocystocele"
    ],
    "gold_answer": "Neural tube defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06139",
    "question": "What is associated with Undetectable visual evoked potentials?",
    "seeds": [
      "Undetectable visual evoked potentials"
    ],
    "gold_answer": "Abnormal brain-evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06140",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 22?",
    "seeds": [
      "Ciliary dyskinesia, primary, 22"
    ],
    "gold_answer": "Webbed neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06141",
    "question": "What phenotype is associated with Corneal dystrophy, Fuchs endothelial, 4?",
    "seeds": [
      "Corneal dystrophy, Fuchs endothelial, 4"
    ],
    "gold_answer": "Corneal guttata",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06142",
    "question": "What is associated with Triangular tongue?",
    "seeds": [
      "Triangular tongue"
    ],
    "gold_answer": "Abnormality of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06143",
    "question": "What is associated with Decreased fucosylation of N-linked protein glycosylation?",
    "seeds": [
      "Decreased fucosylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein N-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06144",
    "question": "What phenotype is associated with Periventricular nodular heterotopia 7?",
    "seeds": [
      "Periventricular nodular heterotopia 7"
    ],
    "gold_answer": "Myopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06145",
    "question": "What is associated with Trichothiodystrophy 7, nonphotosensitive?",
    "seeds": [
      "Trichothiodystrophy 7, nonphotosensitive"
    ],
    "gold_answer": "SULT2B1",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06146",
    "question": "What is associated with Homozygous familial hypercholesterolemia?",
    "seeds": [
      "Homozygous familial hypercholesterolemia"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06147",
    "question": "What is associated with Decreased amplitude of sensory action potentials?",
    "seeds": [
      "Decreased amplitude of sensory action potentials"
    ],
    "gold_answer": "Abnormality of peripheral nerve conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06148",
    "question": "What is associated with Calcific stippling of infantile cartilaginous skeleton?",
    "seeds": [
      "Calcific stippling of infantile cartilaginous skeleton"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06149",
    "question": "What is associated with Arthrogryposis and ectodermal dysplasia?",
    "seeds": [
      "Arthrogryposis and ectodermal dysplasia"
    ],
    "gold_answer": "Upper-limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06150",
    "question": "What is associated with Pulmonary parenchymal band?",
    "seeds": [
      "Pulmonary parenchymal band"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06151",
    "question": "What is associated with Pulmonary arterial hypertension with positive acute response to NO challenge?",
    "seeds": [
      "Pulmonary arterial hypertension with positive acute response to NO challenge"
    ],
    "gold_answer": "Pulmonary arterial hypertension",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06152",
    "question": "What is associated with Reduced imaginative play skills?",
    "seeds": [
      "Reduced imaginative play skills"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06153",
    "question": "What is associated with Congenital factor XII deficiency?",
    "seeds": [
      "Congenital factor XII deficiency"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06154",
    "question": "What is associated with Opsismodysplasia?",
    "seeds": [
      "Opsismodysplasia"
    ],
    "gold_answer": "Abdominal distention",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06155",
    "question": "What is associated with Global proximal tubulopathy?",
    "seeds": [
      "Global proximal tubulopathy"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06156",
    "question": "What is associated with Limitation of joint mobility?",
    "seeds": [
      "Limitation of joint mobility"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06157",
    "question": "What is associated with Urethral sphincter sclerosis?",
    "seeds": [
      "Urethral sphincter sclerosis"
    ],
    "gold_answer": "Urethral stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06158",
    "question": "What is associated with Palmar telangiectasia?",
    "seeds": [
      "Palmar telangiectasia"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06159",
    "question": "What is associated with Ullrich congenital muscular dystrophy 2?",
    "seeds": [
      "Ullrich congenital muscular dystrophy 2"
    ],
    "gold_answer": "Joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06160",
    "question": "What is associated with Reduced beta-hexosaminidase A activity?",
    "seeds": [
      "Reduced beta-hexosaminidase A activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06161",
    "question": "What is associated with Absent dermal elastic fibers?",
    "seeds": [
      "Absent dermal elastic fibers"
    ],
    "gold_answer": "Abnormal cutaneous elastic fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06162",
    "question": "What is associated with Clumping of elastic fibers in the dermis?",
    "seeds": [
      "Clumping of elastic fibers in the dermis"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06163",
    "question": "What is associated with Frontotemporal dementia and/or amyotrophic lateral sclerosis 2?",
    "seeds": [
      "Frontotemporal dementia and/or amyotrophic lateral sclerosis 2"
    ],
    "gold_answer": "CHCHD10",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06164",
    "question": "What is associated with Generalized ichthyosis?",
    "seeds": [
      "Generalized ichthyosis"
    ],
    "gold_answer": "Ichthyosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06165",
    "question": "What is associated with Solitary fibrous tumor?",
    "seeds": [
      "Solitary fibrous tumor"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06166",
    "question": "What is associated with Patchy sclerosis of the distal phalanx of the 5th toe?",
    "seeds": [
      "Patchy sclerosis of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Patchy osteosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06167",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the hallux?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06168",
    "question": "What is associated with Congenital heart defects, multiple types, 2?",
    "seeds": [
      "Congenital heart defects, multiple types, 2"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06169",
    "question": "What phenotype is associated with Severe oculo-renal-cerebellar syndrome?",
    "seeds": [
      "Severe oculo-renal-cerebellar syndrome"
    ],
    "gold_answer": "Hypoplasia of the zygomatic bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06170",
    "question": "What is associated with Shortened inner dynein arms?",
    "seeds": [
      "Shortened inner dynein arms"
    ],
    "gold_answer": "Abnormal respiratory motile cilium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06171",
    "question": "What is associated with Sacralization of the fifth lumbar vertebra?",
    "seeds": [
      "Sacralization of the fifth lumbar vertebra"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06172",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease-deafness-intellectual disability syndrome?",
    "seeds": [
      "Charcot-Marie-Tooth disease-deafness-intellectual disability syndrome"
    ],
    "gold_answer": "Upper limb amyotrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06173",
    "question": "What is associated with Abnormal circulating carnitine concentration?",
    "seeds": [
      "Abnormal circulating carnitine concentration"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06174",
    "question": "What is associated with 4-5 toe syndactyly?",
    "seeds": [
      "4-5 toe syndactyly"
    ],
    "gold_answer": "Syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06175",
    "question": "What is associated with Capillary malformation of the lip?",
    "seeds": [
      "Capillary malformation of the lip"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06176",
    "question": "What is associated with Premature posterior fontanelle closure?",
    "seeds": [
      "Premature posterior fontanelle closure"
    ],
    "gold_answer": "Premature closure of fontanelles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06177",
    "question": "What is associated with Jejunitis?",
    "seeds": [
      "Jejunitis"
    ],
    "gold_answer": "Abnormal small intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06178",
    "question": "What is associated with Anterior encephalocele?",
    "seeds": [
      "Anterior encephalocele"
    ],
    "gold_answer": "Encephalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06179",
    "question": "What is associated with Decreased mannosylation of N-linked protein glycosylation?",
    "seeds": [
      "Decreased mannosylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06180",
    "question": "What is associated with Autosomal dominant adult-onset proximal spinal muscular atrophy?",
    "seeds": [
      "Autosomal dominant adult-onset proximal spinal muscular atrophy"
    ],
    "gold_answer": "Limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06181",
    "question": "What is associated with Recent steroid exposure?",
    "seeds": [
      "Recent steroid exposure"
    ],
    "gold_answer": "Medication history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06182",
    "question": "What is associated with Depressed glabella?",
    "seeds": [
      "Depressed glabella"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06183",
    "question": "What is associated with Temple-Baraitser syndrome?",
    "seeds": [
      "Temple-Baraitser syndrome"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06184",
    "question": "What is associated with Specific anosmia?",
    "seeds": [
      "Specific anosmia"
    ],
    "gold_answer": "Abnormality of the sense of smell",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06185",
    "question": "What is associated with Tibial torsion?",
    "seeds": [
      "Tibial torsion"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06186",
    "question": "What phenotype is associated with Lipid storage myopathy due to flavin adenine dinucleotide synthetase deficiency?",
    "seeds": [
      "Lipid storage myopathy due to flavin adenine dinucleotide synthetase deficiency"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06187",
    "question": "What phenotype is associated with Microcephaly 9, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 9, primary, autosomal recessive"
    ],
    "gold_answer": "Impulsivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06188",
    "question": "What is associated with Abnormality of the periorbital region?",
    "seeds": [
      "Abnormality of the periorbital region"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06189",
    "question": "What is associated with Malonyl-CoA decarboxylase deficiency?",
    "seeds": [
      "Malonyl-CoA decarboxylase deficiency"
    ],
    "gold_answer": "Abnormal blood glucose concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06190",
    "question": "What is associated with Increased size of the clitoris?",
    "seeds": [
      "Increased size of the clitoris"
    ],
    "gold_answer": "Abnormal size of the clitoris",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06191",
    "question": "What is associated with Abnormal foveal pigmentation?",
    "seeds": [
      "Abnormal foveal pigmentation"
    ],
    "gold_answer": "Abnormal foveal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06192",
    "question": "What phenotype is associated with Progressive familial intrahepatic cholestasis?",
    "seeds": [
      "Progressive familial intrahepatic cholestasis"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06193",
    "question": "What is associated with Abnormal urine cytology?",
    "seeds": [
      "Abnormal urine cytology"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06194",
    "question": "What is associated with Glycogen storage disease due to liver phosphorylase kinase deficiency?",
    "seeds": [
      "Glycogen storage disease due to liver phosphorylase kinase deficiency"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06195",
    "question": "What is associated with Abnormality of hair texture?",
    "seeds": [
      "Abnormality of hair texture"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06196",
    "question": "What is associated with Epidermodysplasia verruciformis 2?",
    "seeds": [
      "Epidermodysplasia verruciformis 2"
    ],
    "gold_answer": "Verrucae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06197",
    "question": "What is associated with Neonatal focal clonic seizure?",
    "seeds": [
      "Neonatal focal clonic seizure"
    ],
    "gold_answer": "Neonatal electro-clinical motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06198",
    "question": "What is associated with Speech apraxia?",
    "seeds": [
      "Speech apraxia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06199",
    "question": "What is associated with Broad phalanges of the 5th toe?",
    "seeds": [
      "Broad phalanges of the 5th toe"
    ],
    "gold_answer": "Broad phalanx of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06200",
    "question": "What is associated with Open neural tube defect?",
    "seeds": [
      "Open neural tube defect"
    ],
    "gold_answer": "Abnormal neural tube morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06201",
    "question": "What is associated with Renal vein thrombosis?",
    "seeds": [
      "Renal vein thrombosis"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06202",
    "question": "What is associated with Paraspinal muscle hypertrophy?",
    "seeds": [
      "Paraspinal muscle hypertrophy"
    ],
    "gold_answer": "Abnormality of muscle size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06203",
    "question": "What is associated with Increased level of ribitol in urine?",
    "seeds": [
      "Increased level of ribitol in urine"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06204",
    "question": "What is associated with Iminoglycinuria?",
    "seeds": [
      "Iminoglycinuria"
    ],
    "gold_answer": "Increased proteinogenic amino acid level in urine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06205",
    "question": "What is associated with Praxis-induced seizure?",
    "seeds": [
      "Praxis-induced seizure"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06206",
    "question": "What is associated with Band heterotopia?",
    "seeds": [
      "Band heterotopia"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06207",
    "question": "What is associated with Abnormal morphology of the olfactory bulb?",
    "seeds": [
      "Abnormal morphology of the olfactory bulb"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06208",
    "question": "What is associated with Recurrent pneumonia?",
    "seeds": [
      "Recurrent pneumonia"
    ],
    "gold_answer": "Pneumonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06209",
    "question": "What is associated with Myeloproliferative/lymphoproliferative neoplasms, familial (multiple types), susceptibility to?",
    "seeds": [
      "Myeloproliferative/lymphoproliferative neoplasms, familial (multiple types), susceptibility to"
    ],
    "gold_answer": "Abnormal pericardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06210",
    "question": "What is associated with Partial absence of foot?",
    "seeds": [
      "Partial absence of foot"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06211",
    "question": "What is associated with Abnormal scaphoid morphology?",
    "seeds": [
      "Abnormal scaphoid morphology"
    ],
    "gold_answer": "Abnormality of the wrist",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06212",
    "question": "What is associated with C2-C3 subluxation?",
    "seeds": [
      "C2-C3 subluxation"
    ],
    "gold_answer": "Joint subluxation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06213",
    "question": "What is associated with Increased hepatitis A virus antibody level?",
    "seeds": [
      "Increased hepatitis A virus antibody level"
    ],
    "gold_answer": "Increased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06214",
    "question": "What phenotype is associated with Parkinsonism-Dystonia, infantile, 1?",
    "seeds": [
      "Parkinsonism-Dystonia, infantile, 1"
    ],
    "gold_answer": "Chorea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06215",
    "question": "What is associated with Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive?",
    "seeds": [
      "Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive"
    ],
    "gold_answer": "Prematurely aged appearance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06216",
    "question": "What phenotype is associated with Hypothyroidism, congenital, nongoitrous, 5?",
    "seeds": [
      "Hypothyroidism, congenital, nongoitrous, 5"
    ],
    "gold_answer": "Thyroid hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06217",
    "question": "What is associated with Occupational exposure to raw nonsynthetic textiles?",
    "seeds": [
      "Occupational exposure to raw nonsynthetic textiles"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06218",
    "question": "What is associated with Short esophagus?",
    "seeds": [
      "Short esophagus"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06219",
    "question": "What is associated with Joint subluxation?",
    "seeds": [
      "Joint subluxation"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06220",
    "question": "What is associated with Fasting hyperinsulinemia?",
    "seeds": [
      "Fasting hyperinsulinemia"
    ],
    "gold_answer": "Hyperinsulinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06221",
    "question": "What is associated with Multicentric osteolysis, nodulosis, and arthropathy?",
    "seeds": [
      "Multicentric osteolysis, nodulosis, and arthropathy"
    ],
    "gold_answer": "C1-C2 vertebral abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06222",
    "question": "What phenotype is associated with Microcephaly 29, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 29, primary, autosomal recessive"
    ],
    "gold_answer": "High forehead",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06223",
    "question": "What is associated with Air crescent?",
    "seeds": [
      "Air crescent"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06224",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 40?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 40"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06225",
    "question": "What is associated with Cervical aortic arch?",
    "seeds": [
      "Cervical aortic arch"
    ],
    "gold_answer": "Abnormal branching pattern of the aortic arch",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06226",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 29?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 29"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06227",
    "question": "What is associated with Increased level of gamma-aminobutyric acid in urine?",
    "seeds": [
      "Increased level of gamma-aminobutyric acid in urine"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06228",
    "question": "What is associated with Positive Hawkins test?",
    "seeds": [
      "Positive Hawkins test"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06229",
    "question": "What is associated with Proximal 16p11.2 microdeletion syndrome?",
    "seeds": [
      "Proximal 16p11.2 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06230",
    "question": "What is associated with Cervical instability?",
    "seeds": [
      "Cervical instability"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06231",
    "question": "What is associated with Ivory epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Ivory epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06232",
    "question": "What is associated with Generalized abnormality of skin?",
    "seeds": [
      "Generalized abnormality of skin"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06233",
    "question": "What is associated with Bundle branch block, familial isolated complete right?",
    "seeds": [
      "Bundle branch block, familial isolated complete right"
    ],
    "gold_answer": "Heart block",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06234",
    "question": "What is associated with Elevated urinary 2-oxoisocaproic level?",
    "seeds": [
      "Elevated urinary 2-oxoisocaproic level"
    ],
    "gold_answer": "Increased urine proteinogenic amino acid derivative level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06235",
    "question": "What phenotype is associated with Thymoma, familial?",
    "seeds": [
      "Thymoma, familial"
    ],
    "gold_answer": "Leukopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06236",
    "question": "What phenotype is associated with X-linked dystonia-parkinsonism?",
    "seeds": [
      "X-linked dystonia-parkinsonism"
    ],
    "gold_answer": "Frequent falls",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06237",
    "question": "What is associated with Autoamputation of digits?",
    "seeds": [
      "Autoamputation of digits"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06238",
    "question": "What is associated with Corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome?",
    "seeds": [
      "Corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome"
    ],
    "gold_answer": "Abnormal neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06239",
    "question": "What is associated with Reduced fecal osmolality?",
    "seeds": [
      "Reduced fecal osmolality"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06240",
    "question": "What is associated with Subarterial ventricular septal defect?",
    "seeds": [
      "Subarterial ventricular septal defect"
    ],
    "gold_answer": "Abnormal ventricular septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06241",
    "question": "What is associated with Scheuermann disease?",
    "seeds": [
      "Scheuermann disease"
    ],
    "gold_answer": "Avascular necrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06242",
    "question": "What is associated with Cortical sclerosis?",
    "seeds": [
      "Cortical sclerosis"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06243",
    "question": "What is associated with Cardiac rhabdomyoma?",
    "seeds": [
      "Cardiac rhabdomyoma"
    ],
    "gold_answer": "Neoplasm of the heart",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06244",
    "question": "What phenotype is associated with MELAS?",
    "seeds": [
      "MELAS"
    ],
    "gold_answer": "Nephropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06245",
    "question": "What phenotype is associated with Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome?",
    "seeds": [
      "Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome"
    ],
    "gold_answer": "Large fleshy ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06246",
    "question": "What is associated with Blue rubber bleb nevus?",
    "seeds": [
      "Blue rubber bleb nevus"
    ],
    "gold_answer": "TEK",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06247",
    "question": "What is associated with Intrauterine fetal demise of one twin after midgestation?",
    "seeds": [
      "Intrauterine fetal demise of one twin after midgestation"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06248",
    "question": "What is associated with Increased Z-disc width?",
    "seeds": [
      "Increased Z-disc width"
    ],
    "gold_answer": "Abnormal sarcomere morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06249",
    "question": "What is associated with Parastremmatic dwarfism?",
    "seeds": [
      "Parastremmatic dwarfism"
    ],
    "gold_answer": "Abnormal neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06250",
    "question": "What is associated with Fractured fused sacrum?",
    "seeds": [
      "Fractured fused sacrum"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06251",
    "question": "What is associated with Pathologic fracture?",
    "seeds": [
      "Pathologic fracture"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06252",
    "question": "What is associated with Upper motor neuron dysfunction?",
    "seeds": [
      "Upper motor neuron dysfunction"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06253",
    "question": "What is associated with Glaucoma 1, open angle, O?",
    "seeds": [
      "Glaucoma 1, open angle, O"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06254",
    "question": "What phenotype is associated with Amelogenesis imperfecta?",
    "seeds": [
      "Amelogenesis imperfecta"
    ],
    "gold_answer": "Widely spaced teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06255",
    "question": "What is associated with Positive brain-tissue rabies nucleic acid test?",
    "seeds": [
      "Positive brain-tissue rabies nucleic acid test"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06256",
    "question": "What is associated with Muscle fiber intracytoplasmic reducing inclusion bodies?",
    "seeds": [
      "Muscle fiber intracytoplasmic reducing inclusion bodies"
    ],
    "gold_answer": "Muscle fiber cytoplasmatic inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06257",
    "question": "What is associated with Paramolar tubercle of bolk?",
    "seeds": [
      "Paramolar tubercle of bolk"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06258",
    "question": "What is associated with Brain parenchymal tuberculoma?",
    "seeds": [
      "Brain parenchymal tuberculoma"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06259",
    "question": "What is associated with Chondrosarcoma?",
    "seeds": [
      "Chondrosarcoma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06260",
    "question": "What is associated with Prominent occiput?",
    "seeds": [
      "Prominent occiput"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06261",
    "question": "What is associated with Neuropathy, hereditary, with liability to pressure palsies?",
    "seeds": [
      "Neuropathy, hereditary, with liability to pressure palsies"
    ],
    "gold_answer": "Peripheral demyelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06262",
    "question": "What is associated with Hypnopompic sleep paralysis?",
    "seeds": [
      "Hypnopompic sleep paralysis"
    ],
    "gold_answer": "REM parasomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06263",
    "question": "What phenotype is associated with Blindness-scoliosis-arachnodactyly syndrome?",
    "seeds": [
      "Blindness-scoliosis-arachnodactyly syndrome"
    ],
    "gold_answer": "Arachnodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06264",
    "question": "What phenotype is associated with Severe hemophilia A?",
    "seeds": [
      "Severe hemophilia A"
    ],
    "gold_answer": "Limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06265",
    "question": "What is associated with Abnormality of primary teeth?",
    "seeds": [
      "Abnormality of primary teeth"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06266",
    "question": "What is associated with Episodic kinesigenic dyskinesia 1?",
    "seeds": [
      "Episodic kinesigenic dyskinesia 1"
    ],
    "gold_answer": "Choreoathetosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06267",
    "question": "What is associated with Increased glucose-6-phosphate dehydrogenase level in dried blood spot?",
    "seeds": [
      "Increased glucose-6-phosphate dehydrogenase level in dried blood spot"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06268",
    "question": "What phenotype is associated with Craniometadiaphyseal osteosclerosis with hip dysplasia?",
    "seeds": [
      "Craniometadiaphyseal osteosclerosis with hip dysplasia"
    ],
    "gold_answer": "Abnormal pulmonary valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06269",
    "question": "What is associated with Gaze-evoked horizontal nystagmus?",
    "seeds": [
      "Gaze-evoked horizontal nystagmus"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06270",
    "question": "What is associated with Small acrosomal area?",
    "seeds": [
      "Small acrosomal area"
    ],
    "gold_answer": "Abnormal sperm head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06271",
    "question": "What is associated with Decreased circulating plasmalogen concentration?",
    "seeds": [
      "Decreased circulating plasmalogen concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06272",
    "question": "What is associated with EEG with polyspike wave complexes?",
    "seeds": [
      "EEG with polyspike wave complexes"
    ],
    "gold_answer": "EEG with generalized epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06273",
    "question": "What is associated with 3-methylcrotonyl-CoA carboxylase deficiency?",
    "seeds": [
      "3-methylcrotonyl-CoA carboxylase deficiency"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06274",
    "question": "What is associated with Forceps delivery?",
    "seeds": [
      "Forceps delivery"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06275",
    "question": "What is associated with Impaired cytokine signaling?",
    "seeds": [
      "Impaired cytokine signaling"
    ],
    "gold_answer": "Abnormal cytokine signaling",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06276",
    "question": "What is associated with COFS syndrome?",
    "seeds": [
      "COFS syndrome"
    ],
    "gold_answer": "Flexion contracture of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06277",
    "question": "What is associated with Caribbean parkinsonism?",
    "seeds": [
      "Caribbean parkinsonism"
    ],
    "gold_answer": "Abnormality of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06278",
    "question": "What is associated with Hyperinsulinemia?",
    "seeds": [
      "Hyperinsulinemia"
    ],
    "gold_answer": "Abnormal circulating insulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06279",
    "question": "What is associated with Advanced sleep phase syndrome, familial, 2?",
    "seeds": [
      "Advanced sleep phase syndrome, familial, 2"
    ],
    "gold_answer": "Headache",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06280",
    "question": "What is associated with Hyperphosphaturia?",
    "seeds": [
      "Hyperphosphaturia"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06281",
    "question": "What is associated with Abnormality of the distal phalanx of the 5th toe?",
    "seeds": [
      "Abnormality of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06282",
    "question": "What is associated with Broad middle phalanx of the 5th toe?",
    "seeds": [
      "Broad middle phalanx of the 5th toe"
    ],
    "gold_answer": "Broad phalanges of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06283",
    "question": "What is associated with Enlarged epiphyses of the 2nd toe?",
    "seeds": [
      "Enlarged epiphyses of the 2nd toe"
    ],
    "gold_answer": "Enlarged epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06284",
    "question": "What is associated with RECON progeroid syndrome?",
    "seeds": [
      "RECON progeroid syndrome"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06285",
    "question": "What phenotype is associated with Microphthalmia, syndromic 13?",
    "seeds": [
      "Microphthalmia, syndromic 13"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06286",
    "question": "What is associated with Hypogonadotropic hypogonadism 2 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 2 with or without anosmia"
    ],
    "gold_answer": "Abnormal eating behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06287",
    "question": "What is associated with Thrombophilia, hereditary, due to protein S deficiency, autosomal?",
    "seeds": [
      "Thrombophilia, hereditary, due to protein S deficiency, autosomal"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06288",
    "question": "What phenotype is associated with Heparin cofactor II deficiency?",
    "seeds": [
      "Heparin cofactor II deficiency"
    ],
    "gold_answer": "Recurrent deep vein thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06289",
    "question": "What is associated with Increased serum zinc?",
    "seeds": [
      "Increased serum zinc"
    ],
    "gold_answer": "Abnormal blood transition element cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06290",
    "question": "What is associated with Reduced contrast sensitivity?",
    "seeds": [
      "Reduced contrast sensitivity"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06291",
    "question": "What is associated with Infantile onset?",
    "seeds": [
      "Infantile onset"
    ],
    "gold_answer": "Pediatric onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06292",
    "question": "What phenotype is associated with Ehlers-Danlos syndrome, arthrochalasia type, 1?",
    "seeds": [
      "Ehlers-Danlos syndrome, arthrochalasia type, 1"
    ],
    "gold_answer": "Congenital bilateral hip dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06293",
    "question": "What is associated with Elevated haptoglobin level?",
    "seeds": [
      "Elevated haptoglobin level"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06294",
    "question": "What is associated with Personality changes?",
    "seeds": [
      "Personality changes"
    ],
    "gold_answer": "Impairment in personality functioning",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06295",
    "question": "What is associated with Hepatic melanin-like lysosomal pigmentation?",
    "seeds": [
      "Hepatic melanin-like lysosomal pigmentation"
    ],
    "gold_answer": "Abnormal hepatocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06296",
    "question": "What is associated with Decreased RV/TLC ratio?",
    "seeds": [
      "Decreased RV/TLC ratio"
    ],
    "gold_answer": "Abnormal RV/TLC ratio",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06297",
    "question": "What is associated with Pericardial late gadolinium enhancement?",
    "seeds": [
      "Pericardial late gadolinium enhancement"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06298",
    "question": "What is associated with C1-C2 subluxation?",
    "seeds": [
      "C1-C2 subluxation"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06299",
    "question": "What phenotype is associated with Brachytelephalangy-dysmorphism-Kallmann syndrome?",
    "seeds": [
      "Brachytelephalangy-dysmorphism-Kallmann syndrome"
    ],
    "gold_answer": "Hypoplasia of the zygomatic bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06300",
    "question": "What is associated with Salivary gland neoplasm?",
    "seeds": [
      "Salivary gland neoplasm"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06301",
    "question": "What is associated with Mesenteric venous thrombosis?",
    "seeds": [
      "Mesenteric venous thrombosis"
    ],
    "gold_answer": "Venous thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06302",
    "question": "What is associated with Osteolytic defects of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Osteolytic defects of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Osteolytic defects of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06303",
    "question": "What is associated with Pseudoaneurysm?",
    "seeds": [
      "Pseudoaneurysm"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06304",
    "question": "What is associated with Niemann-Pick disease type C, juvenile neurologic onset?",
    "seeds": [
      "Niemann-Pick disease type C, juvenile neurologic onset"
    ],
    "gold_answer": "NPC1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06305",
    "question": "What is associated with Increased HLA DR+ CD8+ T cell proportion?",
    "seeds": [
      "Increased HLA DR+ CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal CD8+ T cell subset proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06306",
    "question": "What is associated with Neutropenia, severe congenital, 12, autosomal recessive?",
    "seeds": [
      "Neutropenia, severe congenital, 12, autosomal recessive"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06307",
    "question": "What is associated with Distal clavicular thinning?",
    "seeds": [
      "Distal clavicular thinning"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06308",
    "question": "What is associated with Optic atrophy 3, autosomal dominant?",
    "seeds": [
      "Optic atrophy 3, autosomal dominant"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06309",
    "question": "What is associated with Fixed facial expression?",
    "seeds": [
      "Fixed facial expression"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06310",
    "question": "What is associated with Severe sensorineural hearing impairment?",
    "seeds": [
      "Severe sensorineural hearing impairment"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06311",
    "question": "What is associated with Persistent mullerian duct syndrome, types I and II?",
    "seeds": [
      "Persistent mullerian duct syndrome, types I and II"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06312",
    "question": "What is associated with Ciliary dyskinesia, primary, 15?",
    "seeds": [
      "Ciliary dyskinesia, primary, 15"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06313",
    "question": "What is associated with Morning glory anomaly?",
    "seeds": [
      "Morning glory anomaly"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06314",
    "question": "What is associated with Renal arteriolar intraluminal thrombi?",
    "seeds": [
      "Renal arteriolar intraluminal thrombi"
    ],
    "gold_answer": "Abnormal renal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06315",
    "question": "What phenotype is associated with Inflammatory bowel disease 25, early onset, autosomal recessive?",
    "seeds": [
      "Inflammatory bowel disease 25, early onset, autosomal recessive"
    ],
    "gold_answer": "Folliculitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06316",
    "question": "What is associated with Severe toxoplasmosis?",
    "seeds": [
      "Severe toxoplasmosis"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06317",
    "question": "What is associated with Reduced circulating erythropoietin concentration?",
    "seeds": [
      "Reduced circulating erythropoietin concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06318",
    "question": "What is associated with Hepatoencephalopathy due to combined oxidative phosphorylation defect type 1?",
    "seeds": [
      "Hepatoencephalopathy due to combined oxidative phosphorylation defect type 1"
    ],
    "gold_answer": "Abnormal corpus callosum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06319",
    "question": "What is associated with Pink urine?",
    "seeds": [
      "Pink urine"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06320",
    "question": "What is associated with Stippling of the epiphyses of the distal phalanges of the hand?",
    "seeds": [
      "Stippling of the epiphyses of the distal phalanges of the hand"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06321",
    "question": "What phenotype is associated with Brown-Vialetto-Van Laere syndrome 1?",
    "seeds": [
      "Brown-Vialetto-Van Laere syndrome 1"
    ],
    "gold_answer": "External ophthalmoplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06322",
    "question": "What is associated with Spatulate thumbs?",
    "seeds": [
      "Spatulate thumbs"
    ],
    "gold_answer": "Broad phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06323",
    "question": "What phenotype is associated with Cardiac valvular defect, developmental?",
    "seeds": [
      "Cardiac valvular defect, developmental"
    ],
    "gold_answer": "Atrial septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06324",
    "question": "What phenotype is associated with Muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 3?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 3"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06325",
    "question": "What is associated with Reduced muscle dystrophin expression?",
    "seeds": [
      "Reduced muscle dystrophin expression"
    ],
    "gold_answer": "Abnormal muscle fiber dystrophin expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06326",
    "question": "What is associated with Primary congenital glaucoma?",
    "seeds": [
      "Primary congenital glaucoma"
    ],
    "gold_answer": "Developmental glaucoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06327",
    "question": "What is associated with Spinocerebellar ataxia 49?",
    "seeds": [
      "Spinocerebellar ataxia 49"
    ],
    "gold_answer": "Inability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06328",
    "question": "What phenotype is associated with Systemic lupus erythematosus 16?",
    "seeds": [
      "Systemic lupus erythematosus 16"
    ],
    "gold_answer": "Chorea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06329",
    "question": "What is associated with White forelock with malformations?",
    "seeds": [
      "White forelock with malformations"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06330",
    "question": "What is associated with Extension of hair growth on temples to lateral eyebrow?",
    "seeds": [
      "Extension of hair growth on temples to lateral eyebrow"
    ],
    "gold_answer": "Abnormality of the frontal hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06331",
    "question": "What is associated with Metabolic alkalosis?",
    "seeds": [
      "Metabolic alkalosis"
    ],
    "gold_answer": "Alkalosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06332",
    "question": "What is associated with Cardiomyopathy, dilated, 1BB?",
    "seeds": [
      "Cardiomyopathy, dilated, 1BB"
    ],
    "gold_answer": "Heart block",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06333",
    "question": "What is associated with Neoplasm by histology?",
    "seeds": [
      "Neoplasm by histology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06334",
    "question": "What is associated with 1-2 toe syndactyly?",
    "seeds": [
      "1-2 toe syndactyly"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06335",
    "question": "What is associated with Aplastic/Hypoplastic nasopharyngeal adenoids?",
    "seeds": [
      "Aplastic/Hypoplastic nasopharyngeal adenoids"
    ],
    "gold_answer": "Abnormal pharynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06336",
    "question": "What is associated with Bleeding disorder, platelet-type, 13, susceptibility to?",
    "seeds": [
      "Bleeding disorder, platelet-type, 13, susceptibility to"
    ],
    "gold_answer": "Macular purpura",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06337",
    "question": "What phenotype is associated with Global developmental delay-visual anomalies-progressive cerebellar atrophy-truncal hypotonia syndrome?",
    "seeds": [
      "Global developmental delay-visual anomalies-progressive cerebellar atrophy-truncal hypotonia syndrome"
    ],
    "gold_answer": "Retinal arteriolar tortuosity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06338",
    "question": "What is associated with Elevated circulating glutaric acid concentration?",
    "seeds": [
      "Elevated circulating glutaric acid concentration"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06339",
    "question": "What is associated with Abdominal ectopia cordis?",
    "seeds": [
      "Abdominal ectopia cordis"
    ],
    "gold_answer": "Abnormal anatomic location of the heart",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06340",
    "question": "What is associated with Enlarged lunula?",
    "seeds": [
      "Enlarged lunula"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06341",
    "question": "What is associated with Hypercholanemia, familial 2?",
    "seeds": [
      "Hypercholanemia, familial 2"
    ],
    "gold_answer": "Abnormal circulating monocarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06342",
    "question": "What is associated with Thickened mitral valve cusp?",
    "seeds": [
      "Thickened mitral valve cusp"
    ],
    "gold_answer": "Abnormal mitral valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06343",
    "question": "What is associated with Thickened cortex of the ulna?",
    "seeds": [
      "Thickened cortex of the ulna"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06344",
    "question": "What is associated with Reduced tissue thymidine phosphorylase activity?",
    "seeds": [
      "Reduced tissue thymidine phosphorylase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06345",
    "question": "What is associated with Rimmed vacuoles?",
    "seeds": [
      "Rimmed vacuoles"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06346",
    "question": "What is associated with Reduced tissue palmitoyl-protein thioesterase activity?",
    "seeds": [
      "Reduced tissue palmitoyl-protein thioesterase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06347",
    "question": "What is associated with Antineutrophil antibody positivity?",
    "seeds": [
      "Antineutrophil antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06348",
    "question": "What is associated with CAMPTOBRACHYDACTYLY?",
    "seeds": [
      "CAMPTOBRACHYDACTYLY"
    ],
    "gold_answer": "Polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06349",
    "question": "What is associated with Medial/intimal arcuate venosclerosis?",
    "seeds": [
      "Medial/intimal arcuate venosclerosis"
    ],
    "gold_answer": "Abnormal arcuate vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06350",
    "question": "What phenotype is associated with Nuchal bleb, familial?",
    "seeds": [
      "Nuchal bleb, familial"
    ],
    "gold_answer": "Hydrops fetalis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06351",
    "question": "What is associated with Neurodevelopmental disorder with cerebellar atrophy and motor dysfunction?",
    "seeds": [
      "Neurodevelopmental disorder with cerebellar atrophy and motor dysfunction"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06352",
    "question": "What is associated with Small distal femoral epiphysis?",
    "seeds": [
      "Small distal femoral epiphysis"
    ],
    "gold_answer": "Abnormal lower limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06353",
    "question": "What is associated with Spondylocostal dysostosis 5?",
    "seeds": [
      "Spondylocostal dysostosis 5"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06354",
    "question": "What is associated with Chromosome 3q29 deletion syndrome?",
    "seeds": [
      "Chromosome 3q29 deletion syndrome"
    ],
    "gold_answer": "Abnormality of upper lip vermillion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06355",
    "question": "What phenotype is associated with Intellectual disability-muscle weakness-short stature-facial dysmorphism syndrome?",
    "seeds": [
      "Intellectual disability-muscle weakness-short stature-facial dysmorphism syndrome"
    ],
    "gold_answer": "Broad columella",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06356",
    "question": "What is associated with Okihiro syndrome due to 20q13 microdeletion?",
    "seeds": [
      "Okihiro syndrome due to 20q13 microdeletion"
    ],
    "gold_answer": "SALL4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "role_in_the_phenotype_of"
    }
  },
  {
    "query_id": "orph_train_06357",
    "question": "What is associated with Abnormal buccal mucosa morphology?",
    "seeds": [
      "Abnormal buccal mucosa morphology"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06358",
    "question": "What is associated with Pareidolia?",
    "seeds": [
      "Pareidolia"
    ],
    "gold_answer": "Disturbed perception with a stimulus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06359",
    "question": "What is associated with Increased urinary 11-deoxycortisol level?",
    "seeds": [
      "Increased urinary 11-deoxycortisol level"
    ],
    "gold_answer": "Abnormal urine hormone level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06360",
    "question": "What phenotype is associated with Arterial tortuosity syndrome?",
    "seeds": [
      "Arterial tortuosity syndrome"
    ],
    "gold_answer": "Hiatus hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06361",
    "question": "What is associated with Fast-growing nails?",
    "seeds": [
      "Fast-growing nails"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06362",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 71?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 71"
    ],
    "gold_answer": "Simplified gyral pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06363",
    "question": "What is associated with Osteosclerotic metaphyseal dysplasia?",
    "seeds": [
      "Osteosclerotic metaphyseal dysplasia"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06364",
    "question": "What phenotype is associated with Colorectal cancer, susceptibility to, 12?",
    "seeds": [
      "Colorectal cancer, susceptibility to, 12"
    ],
    "gold_answer": "Carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06365",
    "question": "What is associated with Partial abdominal muscle agenesis?",
    "seeds": [
      "Partial abdominal muscle agenesis"
    ],
    "gold_answer": "Abnormal morphology of the abdominal musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06366",
    "question": "What is associated with Trichothiodystrophy 1, photosensitive?",
    "seeds": [
      "Trichothiodystrophy 1, photosensitive"
    ],
    "gold_answer": "Joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06367",
    "question": "What is associated with Aortic smooth muscle cell nuclei loss?",
    "seeds": [
      "Aortic smooth muscle cell nuclei loss"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06368",
    "question": "What is associated with Hypoplasia of maxilla relative to mandible?",
    "seeds": [
      "Hypoplasia of maxilla relative to mandible"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06369",
    "question": "What is associated with Paraganglioma of head and neck?",
    "seeds": [
      "Paraganglioma of head and neck"
    ],
    "gold_answer": "Paraganglioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06370",
    "question": "What is associated with Cone-shaped epiphysis of the distal phalanx of the 5th finger?",
    "seeds": [
      "Cone-shaped epiphysis of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Cone-shaped epiphyses of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06371",
    "question": "What is associated with STING-associated vasculopathy with onset in infancy?",
    "seeds": [
      "STING-associated vasculopathy with onset in infancy"
    ],
    "gold_answer": "STING1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_train_06372",
    "question": "What is associated with Sulfocysteinuria?",
    "seeds": [
      "Sulfocysteinuria"
    ],
    "gold_answer": "Increased proteinogenic amino acid level in urine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06373",
    "question": "What is associated with Lumbar spinal canal stenosis?",
    "seeds": [
      "Lumbar spinal canal stenosis"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06374",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 106?",
    "seeds": [
      "Developmental and epileptic encephalopathy 106"
    ],
    "gold_answer": "Cerebellar hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06375",
    "question": "What is associated with Arrhythmogenic right ventricular dysplasia, familial, 14?",
    "seeds": [
      "Arrhythmogenic right ventricular dysplasia, familial, 14"
    ],
    "gold_answer": "Ventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06376",
    "question": "What is associated with Localized osteoporosis?",
    "seeds": [
      "Localized osteoporosis"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06377",
    "question": "What is associated with Bitemporal hollowing?",
    "seeds": [
      "Bitemporal hollowing"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06378",
    "question": "What is associated with Oocyte maturation defect 7?",
    "seeds": [
      "Oocyte maturation defect 7"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06379",
    "question": "What is associated with Advanced eruption of teeth?",
    "seeds": [
      "Advanced eruption of teeth"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06380",
    "question": "What phenotype is associated with Porokeratosis of Mibelli?",
    "seeds": [
      "Porokeratosis of Mibelli"
    ],
    "gold_answer": "Hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06381",
    "question": "What is associated with Decreased post-bronchodilator forced expiratory volume in one second?",
    "seeds": [
      "Decreased post-bronchodilator forced expiratory volume in one second"
    ],
    "gold_answer": "Reduced forced expiratory volume in one second",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06382",
    "question": "What is associated with Short middle phalanx of the 5th toe?",
    "seeds": [
      "Short middle phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06383",
    "question": "What is associated with Crome syndrome?",
    "seeds": [
      "Crome syndrome"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06384",
    "question": "What is associated with Elevated circulating cartilage oligomeric matrix protein concentration?",
    "seeds": [
      "Elevated circulating cartilage oligomeric matrix protein concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06385",
    "question": "What is associated with Positive stool glutamate dehydrogenase test?",
    "seeds": [
      "Positive stool glutamate dehydrogenase test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06386",
    "question": "What is associated with Polymicrogyria with optic nerve hypoplasia?",
    "seeds": [
      "Polymicrogyria with optic nerve hypoplasia"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06387",
    "question": "What is associated with Atherosclerosis-deafness-diabetes-epilepsy-nephropathy syndrome?",
    "seeds": [
      "Atherosclerosis-deafness-diabetes-epilepsy-nephropathy syndrome"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06388",
    "question": "What is associated with Spinocerebellar ataxia 29, congenital nonprogressive?",
    "seeds": [
      "Spinocerebellar ataxia 29, congenital nonprogressive"
    ],
    "gold_answer": "Hyperactivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06389",
    "question": "What is associated with Papillon-Lefèvre syndrome?",
    "seeds": [
      "Papillon-Lefèvre syndrome"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06390",
    "question": "What is associated with Increased circulating beta-carotene concentration?",
    "seeds": [
      "Increased circulating beta-carotene concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06391",
    "question": "What is associated with Immunodeficiency 39?",
    "seeds": [
      "Immunodeficiency 39"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06392",
    "question": "What phenotype is associated with Cocaine embryofetopathy?",
    "seeds": [
      "Cocaine embryofetopathy"
    ],
    "gold_answer": "Encephalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06393",
    "question": "What is associated with Extramammary Paget disease?",
    "seeds": [
      "Extramammary Paget disease"
    ],
    "gold_answer": "ERBB2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06394",
    "question": "What phenotype is associated with Primary ciliary dyskinesia?",
    "seeds": [
      "Primary ciliary dyskinesia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the thymus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06395",
    "question": "What phenotype is associated with Central areolar choroidal dystrophy?",
    "seeds": [
      "Central areolar choroidal dystrophy"
    ],
    "gold_answer": "Choriocapillaris atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06396",
    "question": "What is associated with Glomerular capillary congestion?",
    "seeds": [
      "Glomerular capillary congestion"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06397",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 102?",
    "seeds": [
      "Developmental and epileptic encephalopathy 102"
    ],
    "gold_answer": "Gastroesophageal reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06398",
    "question": "What is associated with Abnormal capillary physiology?",
    "seeds": [
      "Abnormal capillary physiology"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06399",
    "question": "What is associated with Enlarged joints?",
    "seeds": [
      "Enlarged joints"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06400",
    "question": "What is associated with Whole-immunoglobulin paraproteinemia?",
    "seeds": [
      "Whole-immunoglobulin paraproteinemia"
    ],
    "gold_answer": "Increased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06401",
    "question": "What phenotype is associated with Thanatophoric dysplasia, type II?",
    "seeds": [
      "Thanatophoric dysplasia, type II"
    ],
    "gold_answer": "Cloverleaf skull",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06402",
    "question": "What is associated with Abnormal stereopsis?",
    "seeds": [
      "Abnormal stereopsis"
    ],
    "gold_answer": "Abnormality of binocular vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06403",
    "question": "What is associated with Fullness of paranasal tissue?",
    "seeds": [
      "Fullness of paranasal tissue"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06404",
    "question": "What phenotype is associated with Muscular dystrophy, limb-girdle, type 2H?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, type 2H"
    ],
    "gold_answer": "Areflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06405",
    "question": "What is associated with Perinephric abscess?",
    "seeds": [
      "Perinephric abscess"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06406",
    "question": "What is associated with Diminished neutrophil myeloperoxidase activity?",
    "seeds": [
      "Diminished neutrophil myeloperoxidase activity"
    ],
    "gold_answer": "Abnormal granulocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06407",
    "question": "What is associated with Tracheal tug on inspiration?",
    "seeds": [
      "Tracheal tug on inspiration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06408",
    "question": "What is associated with Small acrosomal area?",
    "seeds": [
      "Small acrosomal area"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06409",
    "question": "What is associated with Abnormal circulating estrogen level?",
    "seeds": [
      "Abnormal circulating estrogen level"
    ],
    "gold_answer": "Abnormal circulating sex hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06410",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 56?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 56"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06411",
    "question": "What is associated with Broad lateral eyebrow?",
    "seeds": [
      "Broad lateral eyebrow"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06412",
    "question": "What is associated with Depletion of mitochondrial DNA in muscle tissue?",
    "seeds": [
      "Depletion of mitochondrial DNA in muscle tissue"
    ],
    "gold_answer": "Abnormality of the mitochondrion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06413",
    "question": "What is associated with Positive trunk flexion test?",
    "seeds": [
      "Positive trunk flexion test"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06414",
    "question": "What is associated with Slow pupillary light response?",
    "seeds": [
      "Slow pupillary light response"
    ],
    "gold_answer": "Abnormal pupillary function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06415",
    "question": "What is associated with Hyperpigmentation in sun-exposed areas?",
    "seeds": [
      "Hyperpigmentation in sun-exposed areas"
    ],
    "gold_answer": "Hyperpigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06416",
    "question": "What is associated with Vascular hamartoma?",
    "seeds": [
      "Vascular hamartoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06417",
    "question": "What is associated with Epilepsy, familial adult myoclonic, 2?",
    "seeds": [
      "Epilepsy, familial adult myoclonic, 2"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06418",
    "question": "What is associated with Leber congenital amaurosis 13?",
    "seeds": [
      "Leber congenital amaurosis 13"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06419",
    "question": "What is associated with Vitiligo-Associated multiple autoimmune disease susceptibility 1?",
    "seeds": [
      "Vitiligo-Associated multiple autoimmune disease susceptibility 1"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06420",
    "question": "What is associated with Upper eyelid edema?",
    "seeds": [
      "Upper eyelid edema"
    ],
    "gold_answer": "Palpebral edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06421",
    "question": "What phenotype is associated with Immunodeficiency 79?",
    "seeds": [
      "Immunodeficiency 79"
    ],
    "gold_answer": "Disseminated cutaneous warts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06422",
    "question": "What is associated with Loose body in joint?",
    "seeds": [
      "Loose body in joint"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06423",
    "question": "What phenotype is associated with Deafness, autosomal dominant 37?",
    "seeds": [
      "Deafness, autosomal dominant 37"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06424",
    "question": "What is associated with Decreased FOXP3-expressing T cell count?",
    "seeds": [
      "Decreased FOXP3-expressing T cell count"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06425",
    "question": "What is associated with Anti-Hu antibody positivity?",
    "seeds": [
      "Anti-Hu antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06426",
    "question": "What is associated with Increased serum estradiol?",
    "seeds": [
      "Increased serum estradiol"
    ],
    "gold_answer": "Abnormal serum estradiol",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06427",
    "question": "What phenotype is associated with Amelogenesis imperfecta, type IF?",
    "seeds": [
      "Amelogenesis imperfecta, type IF"
    ],
    "gold_answer": "Amelogenesis imperfecta",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06428",
    "question": "What is associated with Short stature, auditory canal atresia, mandibular hypoplasia, andskeletal abnormalities?",
    "seeds": [
      "Short stature, auditory canal atresia, mandibular hypoplasia, andskeletal abnormalities"
    ],
    "gold_answer": "Upper limb undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06429",
    "question": "What is associated with Menkes disease?",
    "seeds": [
      "Menkes disease"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06430",
    "question": "What is associated with Iris coloboma?",
    "seeds": [
      "Iris coloboma"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06431",
    "question": "What is associated with Reduced circulating interleukin 12 concentration?",
    "seeds": [
      "Reduced circulating interleukin 12 concentration"
    ],
    "gold_answer": "Abnormal circulating interleukin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06432",
    "question": "What is associated with Oral leukoplakia?",
    "seeds": [
      "Oral leukoplakia"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06433",
    "question": "What phenotype is associated with Attention deficit-hyperactivity disorder 8?",
    "seeds": [
      "Attention deficit-hyperactivity disorder 8"
    ],
    "gold_answer": "Attention deficit hyperactivity disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06434",
    "question": "What is associated with Ureterovesical stenosis?",
    "seeds": [
      "Ureterovesical stenosis"
    ],
    "gold_answer": "Abnormal ureter physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06435",
    "question": "What is associated with Focal absence of the external ear?",
    "seeds": [
      "Focal absence of the external ear"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06436",
    "question": "What is associated with 11q22.2q22.3 microdeletion syndrome?",
    "seeds": [
      "11q22.2q22.3 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06437",
    "question": "What is associated with Venous thrombosis?",
    "seeds": [
      "Venous thrombosis"
    ],
    "gold_answer": "Abnormal thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06438",
    "question": "What is associated with Immunodeficiency 13?",
    "seeds": [
      "Immunodeficiency 13"
    ],
    "gold_answer": "Abnormal leukocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06439",
    "question": "What is associated with Plasmacytoma?",
    "seeds": [
      "Plasmacytoma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06440",
    "question": "What phenotype is associated with Spermatogenic failure 23?",
    "seeds": [
      "Spermatogenic failure 23"
    ],
    "gold_answer": "Male infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06441",
    "question": "What is associated with Pancreatic fistula?",
    "seeds": [
      "Pancreatic fistula"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06442",
    "question": "What is associated with Gastric lymphoma?",
    "seeds": [
      "Gastric lymphoma"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06443",
    "question": "What is associated with Abnormal brain morphology?",
    "seeds": [
      "Abnormal brain morphology"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06444",
    "question": "What is associated with T-cell large granular lymphocyte leukemia?",
    "seeds": [
      "T-cell large granular lymphocyte leukemia"
    ],
    "gold_answer": "STAT3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06445",
    "question": "What is associated with Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4?",
    "seeds": [
      "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06446",
    "question": "What is associated with Reduced TSH response to thyrotrophin-releasing hormone stimulation test?",
    "seeds": [
      "Reduced TSH response to thyrotrophin-releasing hormone stimulation test"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06447",
    "question": "What is associated with Neurodevelopmental disorder with seizures and brain abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with seizures and brain abnormalities"
    ],
    "gold_answer": "Diagnostic behavioral phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06448",
    "question": "What is associated with Ulnar metaphyseal irregularity?",
    "seeds": [
      "Ulnar metaphyseal irregularity"
    ],
    "gold_answer": "Metaphyseal irregularity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06449",
    "question": "What is associated with Abnormal vascular physiology?",
    "seeds": [
      "Abnormal vascular physiology"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06450",
    "question": "What is associated with Stercoral ulcer?",
    "seeds": [
      "Stercoral ulcer"
    ],
    "gold_answer": "Abnormal digestive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06451",
    "question": "What is associated with Thick growth plates?",
    "seeds": [
      "Thick growth plates"
    ],
    "gold_answer": "Abnormal growth plate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06452",
    "question": "What is associated with Benign hereditary chorea?",
    "seeds": [
      "Benign hereditary chorea"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06453",
    "question": "What is associated with Abnormal flow cytometry test result?",
    "seeds": [
      "Abnormal flow cytometry test result"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06454",
    "question": "What is associated with Deafness-craniofacial syndrome?",
    "seeds": [
      "Deafness-craniofacial syndrome"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06455",
    "question": "What is associated with Trapezoidal vertebral body?",
    "seeds": [
      "Trapezoidal vertebral body"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06456",
    "question": "What is associated with Neoplasm of the thymus?",
    "seeds": [
      "Neoplasm of the thymus"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06457",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease type 2B1?",
    "seeds": [
      "Charcot-Marie-Tooth disease type 2B1"
    ],
    "gold_answer": "Proximal muscle weakness in lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06458",
    "question": "What is associated with Renal medullary pyramid hypoplasia?",
    "seeds": [
      "Renal medullary pyramid hypoplasia"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06459",
    "question": "What is associated with Decreased FOXP3-expressing T cell count?",
    "seeds": [
      "Decreased FOXP3-expressing T cell count"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06460",
    "question": "What is associated with Bracket epiphyses of the hallux?",
    "seeds": [
      "Bracket epiphyses of the hallux"
    ],
    "gold_answer": "Bracket epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06461",
    "question": "What phenotype is associated with Cranioectodermal dysplasia 2?",
    "seeds": [
      "Cranioectodermal dysplasia 2"
    ],
    "gold_answer": "Cystic hygroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06462",
    "question": "What is associated with Enlarged epididymis?",
    "seeds": [
      "Enlarged epididymis"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06463",
    "question": "What is associated with Secondary Caesarian section?",
    "seeds": [
      "Secondary Caesarian section"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06464",
    "question": "What is associated with Curved distal phalanx of the 2nd toe?",
    "seeds": [
      "Curved distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal 2nd toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06465",
    "question": "What is associated with Trichinellosis?",
    "seeds": [
      "Trichinellosis"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06466",
    "question": "What is associated with Uric acid nephrolithiasis?",
    "seeds": [
      "Uric acid nephrolithiasis"
    ],
    "gold_answer": "Nephrolithiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06467",
    "question": "What is associated with Fractured proximal phalanx of digit 5?",
    "seeds": [
      "Fractured proximal phalanx of digit 5"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06468",
    "question": "What is associated with Spastic paraplegia 36, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 36, autosomal dominant"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06469",
    "question": "What is associated with Hepatic lipase deficiency?",
    "seeds": [
      "Hepatic lipase deficiency"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06470",
    "question": "What is associated with Splenopancreatic fusion?",
    "seeds": [
      "Splenopancreatic fusion"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06471",
    "question": "What is associated with Coronary artery spasm?",
    "seeds": [
      "Coronary artery spasm"
    ],
    "gold_answer": "Abnormal arterial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06472",
    "question": "What is associated with Postaxial hand polydactyly?",
    "seeds": [
      "Postaxial hand polydactyly"
    ],
    "gold_answer": "Duplication of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06473",
    "question": "What phenotype is associated with Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia?",
    "seeds": [
      "Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia"
    ],
    "gold_answer": "Limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06474",
    "question": "What phenotype is associated with Noduli cutanei, multiple, with urinary tract abnormalities?",
    "seeds": [
      "Noduli cutanei, multiple, with urinary tract abnormalities"
    ],
    "gold_answer": "Duplicated collecting system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06475",
    "question": "What is associated with Sclerosis of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06476",
    "question": "What is associated with Increased fetal head circumference?",
    "seeds": [
      "Increased fetal head circumference"
    ],
    "gold_answer": "Abnormal fetal head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06477",
    "question": "What is associated with Dermal ridges, nelson syndrome?",
    "seeds": [
      "Dermal ridges, nelson syndrome"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06478",
    "question": "What is associated with Triangular shaped distal phalanx of the 5th toe?",
    "seeds": [
      "Triangular shaped distal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the phalanges of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06479",
    "question": "What is associated with Nephrotic syndrome, type 15?",
    "seeds": [
      "Nephrotic syndrome, type 15"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06480",
    "question": "What phenotype is associated with Developmental delay-facial dysmorphism syndrome due to MED13L deficiency?",
    "seeds": [
      "Developmental delay-facial dysmorphism syndrome due to MED13L deficiency"
    ],
    "gold_answer": "Downturned corners of mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06481",
    "question": "What is associated with Pure ground-glass pulmonary nodule?",
    "seeds": [
      "Pure ground-glass pulmonary nodule"
    ],
    "gold_answer": "Subsolid pulmonary nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06482",
    "question": "What is associated with Focal aware vocal automatism seizure?",
    "seeds": [
      "Focal aware vocal automatism seizure"
    ],
    "gold_answer": "Focal aware automatism seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06483",
    "question": "What is associated with Arcuate intimal/medial granulomatous venulitis?",
    "seeds": [
      "Arcuate intimal/medial granulomatous venulitis"
    ],
    "gold_answer": "Abnormal arcuate vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06484",
    "question": "What is associated with FLNC-related handgrip and calf weakness-distal myopathy?",
    "seeds": [
      "FLNC-related handgrip and calf weakness-distal myopathy"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06485",
    "question": "What is associated with Distal fifth finger symphalangism?",
    "seeds": [
      "Distal fifth finger symphalangism"
    ],
    "gold_answer": "Finger symphalangism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06486",
    "question": "What is associated with Congenital muscular dystrophy with integrin alpha-7 deficiency?",
    "seeds": [
      "Congenital muscular dystrophy with integrin alpha-7 deficiency"
    ],
    "gold_answer": "ITGA7",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06487",
    "question": "What is associated with Immunodeficiency, common variable, 14?",
    "seeds": [
      "Immunodeficiency, common variable, 14"
    ],
    "gold_answer": "Decreased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06488",
    "question": "What is associated with Hyperphosphatasia-intellectual disability syndrome?",
    "seeds": [
      "Hyperphosphatasia-intellectual disability syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the nails",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06489",
    "question": "What is associated with BRESEK syndrome?",
    "seeds": [
      "BRESEK syndrome"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06490",
    "question": "What is associated with Reduced muscle enolase activity?",
    "seeds": [
      "Reduced muscle enolase activity"
    ],
    "gold_answer": "Abnormal enzyme activity in muscle tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06491",
    "question": "What is associated with Palmar hyperlinearity?",
    "seeds": [
      "Palmar hyperlinearity"
    ],
    "gold_answer": "Abnormal palm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06492",
    "question": "What is associated with Retinitis pigmentosa 25?",
    "seeds": [
      "Retinitis pigmentosa 25"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06493",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 43?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 43"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06494",
    "question": "What is associated with Exercise-induced hemolysis?",
    "seeds": [
      "Exercise-induced hemolysis"
    ],
    "gold_answer": "Hemolytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06495",
    "question": "What is associated with Myoclonic spasms?",
    "seeds": [
      "Myoclonic spasms"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06496",
    "question": "What is associated with Epilepsy, nocturnal frontal lobe, 5?",
    "seeds": [
      "Epilepsy, nocturnal frontal lobe, 5"
    ],
    "gold_answer": "Abnormal psychotic pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06497",
    "question": "What is associated with Bullet-shaped middle phalanx of toe?",
    "seeds": [
      "Bullet-shaped middle phalanx of toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06498",
    "question": "What is associated with Abnormal platelet membrane protein expression?",
    "seeds": [
      "Abnormal platelet membrane protein expression"
    ],
    "gold_answer": "Abnormal platelet function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06499",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 12?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 12"
    ],
    "gold_answer": "Generalized-onset motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06500",
    "question": "What phenotype is associated with Dyserythropoiesis, congenital, with ultrastructurally normal erythroblastheterochromatin?",
    "seeds": [
      "Dyserythropoiesis, congenital, with ultrastructurally normal erythroblastheterochromatin"
    ],
    "gold_answer": "Anisocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06501",
    "question": "What phenotype is associated with Perrault syndrome 5?",
    "seeds": [
      "Perrault syndrome 5"
    ],
    "gold_answer": "Primary amenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06502",
    "question": "What is associated with Thick anterior alveolar ridges?",
    "seeds": [
      "Thick anterior alveolar ridges"
    ],
    "gold_answer": "Alveolar ridge overgrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06503",
    "question": "What is associated with Trichothiodystrophy 9, nonphotosensitive?",
    "seeds": [
      "Trichothiodystrophy 9, nonphotosensitive"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06504",
    "question": "What is associated with Complete duplication of hallux phalanx?",
    "seeds": [
      "Complete duplication of hallux phalanx"
    ],
    "gold_answer": "Duplication of phalanx of hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06505",
    "question": "What is associated with Coma?",
    "seeds": [
      "Coma"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06506",
    "question": "What is associated with Glaucoma 3, primary congenital, A?",
    "seeds": [
      "Glaucoma 3, primary congenital, A"
    ],
    "gold_answer": "Abnormally large globe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06507",
    "question": "What is associated with Hypoperistalsis?",
    "seeds": [
      "Hypoperistalsis"
    ],
    "gold_answer": "Abnormal gastrointestinal motility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06508",
    "question": "What is associated with Descending aortic dissection?",
    "seeds": [
      "Descending aortic dissection"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06509",
    "question": "What phenotype is associated with Microsporidiosis?",
    "seeds": [
      "Microsporidiosis"
    ],
    "gold_answer": "Sinusitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06510",
    "question": "What is associated with Abnormal circulating serine concentration?",
    "seeds": [
      "Abnormal circulating serine concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06511",
    "question": "What is associated with Penile freckling?",
    "seeds": [
      "Penile freckling"
    ],
    "gold_answer": "Abnormal penis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06512",
    "question": "What is associated with Developmental and epileptic encephalopathy 112?",
    "seeds": [
      "Developmental and epileptic encephalopathy 112"
    ],
    "gold_answer": "Disinhibition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06513",
    "question": "What is associated with Oval macrocytosis?",
    "seeds": [
      "Oval macrocytosis"
    ],
    "gold_answer": "Poikilocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06514",
    "question": "What is associated with Parkinsonism-dystonia, infantile, 2?",
    "seeds": [
      "Parkinsonism-dystonia, infantile, 2"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06515",
    "question": "What is associated with Typically de novo?",
    "seeds": [
      "Typically de novo"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06516",
    "question": "What is associated with Maintenance insomnia?",
    "seeds": [
      "Maintenance insomnia"
    ],
    "gold_answer": "Insomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06517",
    "question": "What is associated with Hyperechogenic pancreas?",
    "seeds": [
      "Hyperechogenic pancreas"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06518",
    "question": "What phenotype is associated with Thyroid hormonogenesis, genetic defect in, 4?",
    "seeds": [
      "Thyroid hormonogenesis, genetic defect in, 4"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06519",
    "question": "What is associated with Atresia of the Eustachian tube?",
    "seeds": [
      "Atresia of the Eustachian tube"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06520",
    "question": "What is associated with Cutis laxa, autosomal recessive, type IIA?",
    "seeds": [
      "Cutis laxa, autosomal recessive, type IIA"
    ],
    "gold_answer": "Intracranial cystic lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06521",
    "question": "What is associated with Abnormal mandibular ramus morphology?",
    "seeds": [
      "Abnormal mandibular ramus morphology"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06522",
    "question": "What is associated with Abnormal auditory evoked potentials?",
    "seeds": [
      "Abnormal auditory evoked potentials"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06523",
    "question": "What is associated with Collagenoma, familial cutaneous?",
    "seeds": [
      "Collagenoma, familial cutaneous"
    ],
    "gold_answer": "Atrioventricular valve regurgitation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06524",
    "question": "What phenotype is associated with Leukoencephalopathy, progressive, infantile-onset, with or without deafness?",
    "seeds": [
      "Leukoencephalopathy, progressive, infantile-onset, with or without deafness"
    ],
    "gold_answer": "Congenital sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06525",
    "question": "What is associated with Subretinal hyporeflective spaces on macular OCT?",
    "seeds": [
      "Subretinal hyporeflective spaces on macular OCT"
    ],
    "gold_answer": "Abnormal retinal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06526",
    "question": "What is associated with Interlobular vein medial hypertrophy?",
    "seeds": [
      "Interlobular vein medial hypertrophy"
    ],
    "gold_answer": "Abnormal interlobular vein intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06527",
    "question": "What is associated with Increased urinary cortisol level?",
    "seeds": [
      "Increased urinary cortisol level"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06528",
    "question": "What phenotype is associated with Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3?",
    "seeds": [
      "Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3"
    ],
    "gold_answer": "Sparse pubic hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06529",
    "question": "What is associated with Fractured shoulder?",
    "seeds": [
      "Fractured shoulder"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06530",
    "question": "What is associated with Cleft helix?",
    "seeds": [
      "Cleft helix"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06531",
    "question": "What is associated with Spontaneous lens capsule rupture?",
    "seeds": [
      "Spontaneous lens capsule rupture"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06532",
    "question": "What is associated with C3 nephritic factor positivity?",
    "seeds": [
      "C3 nephritic factor positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06533",
    "question": "What is associated with Reduced phytanic acid oxidase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced phytanic acid oxidase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06534",
    "question": "What is associated with Glycinuria with or without oxalate urolithiasis?",
    "seeds": [
      "Glycinuria with or without oxalate urolithiasis"
    ],
    "gold_answer": "Nephrolithiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06535",
    "question": "What phenotype is associated with Ramos-Arroyo syndrome?",
    "seeds": [
      "Ramos-Arroyo syndrome"
    ],
    "gold_answer": "Keratitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06536",
    "question": "What is associated with Ambiguous genitalia, female?",
    "seeds": [
      "Ambiguous genitalia, female"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06537",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 62?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 62"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06538",
    "question": "What is associated with SUSCEPTIBILITY TO LYSIS BY ALLOREACTIVE NATURAL KILLER CELLS?",
    "seeds": [
      "SUSCEPTIBILITY TO LYSIS BY ALLOREACTIVE NATURAL KILLER CELLS"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06539",
    "question": "What is associated with Abnormal circulating retinol-binding protein concentration?",
    "seeds": [
      "Abnormal circulating retinol-binding protein concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06540",
    "question": "What is associated with Bullet-shaped middle phalanx of the 3rd finger?",
    "seeds": [
      "Bullet-shaped middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Bullet-shaped middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06541",
    "question": "What is associated with Expanded terminal portion of crus of helix?",
    "seeds": [
      "Expanded terminal portion of crus of helix"
    ],
    "gold_answer": "Abnormal cartilage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06542",
    "question": "What is associated with SIMHA syndrome?",
    "seeds": [
      "SIMHA syndrome"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06543",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 53?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 53"
    ],
    "gold_answer": "Abnormal bowel sounds",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06544",
    "question": "What is associated with Aortic elastic fiber thinning?",
    "seeds": [
      "Aortic elastic fiber thinning"
    ],
    "gold_answer": "Medial degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06545",
    "question": "What is associated with Patella alta?",
    "seeds": [
      "Patella alta"
    ],
    "gold_answer": "Abnormal patella morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06546",
    "question": "What is associated with Abnormality of the shoulder girdle musculature?",
    "seeds": [
      "Abnormality of the shoulder girdle musculature"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06547",
    "question": "What is associated with Abnormal prostate morphology?",
    "seeds": [
      "Abnormal prostate morphology"
    ],
    "gold_answer": "Abnormal male internal genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06548",
    "question": "What is associated with Elevated CSF beta-alanine concentration?",
    "seeds": [
      "Elevated CSF beta-alanine concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06549",
    "question": "What is associated with Decreased platelet glycoprotein Ib-IX-V?",
    "seeds": [
      "Decreased platelet glycoprotein Ib-IX-V"
    ],
    "gold_answer": "Abnormal platelet function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06550",
    "question": "What is associated with Recurrent urinary tract infections?",
    "seeds": [
      "Recurrent urinary tract infections"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06551",
    "question": "What is associated with Abnormal lexical patterns?",
    "seeds": [
      "Abnormal lexical patterns"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06552",
    "question": "What phenotype is associated with Cortical blindness-intellectual disability-polydactyly syndrome?",
    "seeds": [
      "Cortical blindness-intellectual disability-polydactyly syndrome"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06553",
    "question": "What is associated with Spinocerebellar ataxia type 10?",
    "seeds": [
      "Spinocerebellar ataxia type 10"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06554",
    "question": "What is associated with Anti-desmoplakin II antibody positivity?",
    "seeds": [
      "Anti-desmoplakin II antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06555",
    "question": "What is associated with Elevated circulating dodecenoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating dodecenoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06556",
    "question": "What is associated with Beta-ureidopropionase deficiency?",
    "seeds": [
      "Beta-ureidopropionase deficiency"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06557",
    "question": "What phenotype is associated with Premature ovarian failure 5?",
    "seeds": [
      "Premature ovarian failure 5"
    ],
    "gold_answer": "Primary amenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06558",
    "question": "What is associated with Malan syndrome?",
    "seeds": [
      "Malan syndrome"
    ],
    "gold_answer": "Increased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06559",
    "question": "What is associated with Telangiectasia, hereditary hemorrhagic, type 2?",
    "seeds": [
      "Telangiectasia, hereditary hemorrhagic, type 2"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06560",
    "question": "What phenotype is associated with Keppen-Lubinsky syndrome?",
    "seeds": [
      "Keppen-Lubinsky syndrome"
    ],
    "gold_answer": "Febrile seizure (within the age range of 3 months to 6 years)",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06561",
    "question": "What is associated with Avian influenza?",
    "seeds": [
      "Avian influenza"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06562",
    "question": "What is associated with Glutaric aciduria III?",
    "seeds": [
      "Glutaric aciduria III"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06563",
    "question": "What is associated with Dysorthography?",
    "seeds": [
      "Dysorthography"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06564",
    "question": "What is associated with Complement component c1r deficiency?",
    "seeds": [
      "Complement component c1r deficiency"
    ],
    "gold_answer": "Abnormality of complement system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06565",
    "question": "What is associated with Renal chloride wasting?",
    "seeds": [
      "Renal chloride wasting"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06566",
    "question": "What is associated with Abnormality of facial soft tissue?",
    "seeds": [
      "Abnormality of facial soft tissue"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06567",
    "question": "What is associated with Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis?",
    "seeds": [
      "Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06568",
    "question": "What is associated with Bietti crystalline dystrophy?",
    "seeds": [
      "Bietti crystalline dystrophy"
    ],
    "gold_answer": "Abnormal light- and dark-adapted electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06569",
    "question": "What is associated with Left Isomerism?",
    "seeds": [
      "Left Isomerism"
    ],
    "gold_answer": "Isomerism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06570",
    "question": "What is associated with Neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities"
    ],
    "gold_answer": "Abnormal location of ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06571",
    "question": "What is associated with Hypoplastic nasal bridge?",
    "seeds": [
      "Hypoplastic nasal bridge"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06572",
    "question": "What is associated with Refsum disease?",
    "seeds": [
      "Refsum disease"
    ],
    "gold_answer": "Abnormality of the urinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06573",
    "question": "What is associated with Bounding pulse?",
    "seeds": [
      "Bounding pulse"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06574",
    "question": "What is associated with Cerebrooculofacioskeletal syndrome 1?",
    "seeds": [
      "Cerebrooculofacioskeletal syndrome 1"
    ],
    "gold_answer": "Abnormality of globe location",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06575",
    "question": "What is associated with Broad 5th toe?",
    "seeds": [
      "Broad 5th toe"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06576",
    "question": "What is associated with Global proximal tubulopathy?",
    "seeds": [
      "Global proximal tubulopathy"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06577",
    "question": "What is associated with Tongue telangiectasia?",
    "seeds": [
      "Tongue telangiectasia"
    ],
    "gold_answer": "Oral cavity telangiectasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06578",
    "question": "What is associated with Pseudoepiphysis of the 3rd metacarpal?",
    "seeds": [
      "Pseudoepiphysis of the 3rd metacarpal"
    ],
    "gold_answer": "Pseudoepiphyses of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06579",
    "question": "What is associated with Response to drugs acting on neuromuscular transmission?",
    "seeds": [
      "Response to drugs acting on neuromuscular transmission"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06580",
    "question": "What is associated with Autosomal erythropoietic protoporphyria?",
    "seeds": [
      "Autosomal erythropoietic protoporphyria"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06581",
    "question": "What is associated with Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome?",
    "seeds": [
      "Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06582",
    "question": "What is associated with Gastrointestinal stroma tumor?",
    "seeds": [
      "Gastrointestinal stroma tumor"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06583",
    "question": "What is associated with Auditory hypersensitivity?",
    "seeds": [
      "Auditory hypersensitivity"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06584",
    "question": "What is associated with Retinitis pigmentosa-hearing loss-premature aging-short stature-facial dysmorphism syndrome?",
    "seeds": [
      "Retinitis pigmentosa-hearing loss-premature aging-short stature-facial dysmorphism syndrome"
    ],
    "gold_answer": "EXOSC2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06585",
    "question": "What is associated with Severely reduced left ventricular ejection fraction?",
    "seeds": [
      "Severely reduced left ventricular ejection fraction"
    ],
    "gold_answer": "Abnormal left ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06586",
    "question": "What is associated with Low tetrahydrocortisol (THF) plus 5-alpha-THF/tetrahydrocortisone (THE) ratio?",
    "seeds": [
      "Low tetrahydrocortisol (THF) plus 5-alpha-THF/tetrahydrocortisone (THE) ratio"
    ],
    "gold_answer": "Abnormality of circulating cortisol level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06587",
    "question": "What phenotype is associated with Johanson-Blizzard syndrome?",
    "seeds": [
      "Johanson-Blizzard syndrome"
    ],
    "gold_answer": "Agenesis of central incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06588",
    "question": "What phenotype is associated with Growth delay-intellectual disability-hepatopathy syndrome?",
    "seeds": [
      "Growth delay-intellectual disability-hepatopathy syndrome"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06589",
    "question": "What is associated with Hyperglycerolemia?",
    "seeds": [
      "Hyperglycerolemia"
    ],
    "gold_answer": "Abnormal circulating glycerol level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06590",
    "question": "What is associated with Abnormality of the epiphysis of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Abnormality of the epiphysis of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06591",
    "question": "What is associated with Femur-fibula-ulna complex?",
    "seeds": [
      "Femur-fibula-ulna complex"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06592",
    "question": "What is associated with Nail dysplasia?",
    "seeds": [
      "Nail dysplasia"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06593",
    "question": "What is associated with Pretragal ectopia?",
    "seeds": [
      "Pretragal ectopia"
    ],
    "gold_answer": "Abnormal midface morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06594",
    "question": "What is associated with Migraine?",
    "seeds": [
      "Migraine"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06595",
    "question": "What is associated with Abnormal urinary uromodulin level?",
    "seeds": [
      "Abnormal urinary uromodulin level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06596",
    "question": "What is associated with Renal interstitial edema?",
    "seeds": [
      "Renal interstitial edema"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06597",
    "question": "What is associated with CNS foam cells?",
    "seeds": [
      "CNS foam cells"
    ],
    "gold_answer": "Foam cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06598",
    "question": "What is associated with Rectal perforation?",
    "seeds": [
      "Rectal perforation"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06599",
    "question": "What phenotype is associated with Mitochondrial DNA depletion syndrome 12A (cardiomyopathic type), autosomal dominant?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 12A (cardiomyopathic type), autosomal dominant"
    ],
    "gold_answer": "Lactic acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06600",
    "question": "What phenotype is associated with IgG4-related retroperitoneal fibrosis?",
    "seeds": [
      "IgG4-related retroperitoneal fibrosis"
    ],
    "gold_answer": "Constipation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06601",
    "question": "What is associated with Transient decreased circulating IgA?",
    "seeds": [
      "Transient decreased circulating IgA"
    ],
    "gold_answer": "Decreased circulating IgA concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06602",
    "question": "What phenotype is associated with Sagliker syndrome?",
    "seeds": [
      "Sagliker syndrome"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06603",
    "question": "What is associated with Histidinuria due to A renal tubular defect?",
    "seeds": [
      "Histidinuria due to A renal tubular defect"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06604",
    "question": "What phenotype is associated with Epidermodysplasia verruciformis 2?",
    "seeds": [
      "Epidermodysplasia verruciformis 2"
    ],
    "gold_answer": "Verruca plana",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06605",
    "question": "What is associated with Abnormality of the distal phalanx of the 5th toe?",
    "seeds": [
      "Abnormality of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06606",
    "question": "What is associated with Aplasia/Hypoplasia of the middle phalanx of the 2nd toe?",
    "seeds": [
      "Aplasia/Hypoplasia of the middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06607",
    "question": "What is associated with Portal hypertension, noncirrhotic?",
    "seeds": [
      "Portal hypertension, noncirrhotic"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06608",
    "question": "What is associated with Mitochondrial respiratory chain defects?",
    "seeds": [
      "Mitochondrial respiratory chain defects"
    ],
    "gold_answer": "Abnormality of the mitochondrion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06609",
    "question": "What phenotype is associated with Atrial septal defect, ostium primum type?",
    "seeds": [
      "Atrial septal defect, ostium primum type"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06610",
    "question": "What is associated with Fractured proximal epiphysis of first metacarpal bone?",
    "seeds": [
      "Fractured proximal epiphysis of first metacarpal bone"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06611",
    "question": "What is associated with Reduced fibroblast CD16 level?",
    "seeds": [
      "Reduced fibroblast CD16 level"
    ],
    "gold_answer": "Reduced cell surface marker level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06612",
    "question": "What is associated with Aplasia of the distal phalanx of the thumb?",
    "seeds": [
      "Aplasia of the distal phalanx of the thumb"
    ],
    "gold_answer": "Aplasia involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06613",
    "question": "What phenotype is associated with Immunodeficiency 106, susceptibility to viral infections?",
    "seeds": [
      "Immunodeficiency 106, susceptibility to viral infections"
    ],
    "gold_answer": "Post-vaccination yellow fever",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06614",
    "question": "What phenotype is associated with Glycogen storage disease VII?",
    "seeds": [
      "Glycogen storage disease VII"
    ],
    "gold_answer": "Exercise-induced muscle fatigue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06615",
    "question": "What is associated with Hypoplastic right ventricle?",
    "seeds": [
      "Hypoplastic right ventricle"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06616",
    "question": "What is associated with Anti-glomerular basement membrane-antibody positivity?",
    "seeds": [
      "Anti-glomerular basement membrane-antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06617",
    "question": "What is associated with Periorbital fullness?",
    "seeds": [
      "Periorbital fullness"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06618",
    "question": "What is associated with EEG with 4-5/second background activity?",
    "seeds": [
      "EEG with 4-5/second background activity"
    ],
    "gold_answer": "EEG with constitutional variants",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06619",
    "question": "What is associated with Abnormal auditory canal morphology?",
    "seeds": [
      "Abnormal auditory canal morphology"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06620",
    "question": "What is associated with Coronary artery aneurysm?",
    "seeds": [
      "Coronary artery aneurysm"
    ],
    "gold_answer": "Abnormal coronary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06621",
    "question": "What phenotype is associated with Periventricular nodular heterotopia?",
    "seeds": [
      "Periventricular nodular heterotopia"
    ],
    "gold_answer": "Aortic aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06622",
    "question": "What is associated with Elevated urine 3-hydroxysebacic acid level?",
    "seeds": [
      "Elevated urine 3-hydroxysebacic acid level"
    ],
    "gold_answer": "Aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06623",
    "question": "What is associated with Irregularly shaped keratohyaline granules?",
    "seeds": [
      "Irregularly shaped keratohyaline granules"
    ],
    "gold_answer": "Abnormal epidermal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06624",
    "question": "What is associated with Axillary epidermoid cyst?",
    "seeds": [
      "Axillary epidermoid cyst"
    ],
    "gold_answer": "Epidermoid cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06625",
    "question": "What is associated with 3-methylglutaconic aciduria, type I?",
    "seeds": [
      "3-methylglutaconic aciduria, type I"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06626",
    "question": "What is associated with Pseudoepiphysis of the distal phalanx of the 2nd finger?",
    "seeds": [
      "Pseudoepiphysis of the distal phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06627",
    "question": "What phenotype is associated with Dentin dysplasia, type II?",
    "seeds": [
      "Dentin dysplasia, type II"
    ],
    "gold_answer": "Generalized hypoplasia of dental enamel",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06628",
    "question": "What is associated with Eversion of lateral third of lower eyelids?",
    "seeds": [
      "Eversion of lateral third of lower eyelids"
    ],
    "gold_answer": "Ectropion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06629",
    "question": "What is associated with Thickened tricuspid valve cusp?",
    "seeds": [
      "Thickened tricuspid valve cusp"
    ],
    "gold_answer": "Abnormal heart valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06630",
    "question": "What is associated with Absent frontal sinuses?",
    "seeds": [
      "Absent frontal sinuses"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the frontal sinuses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06631",
    "question": "What is associated with Peripheral neuroepithelioma?",
    "seeds": [
      "Peripheral neuroepithelioma"
    ],
    "gold_answer": "Neoplasm of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06632",
    "question": "What is associated with Retinal arteritis?",
    "seeds": [
      "Retinal arteritis"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06633",
    "question": "What is associated with Right ventricular failure?",
    "seeds": [
      "Right ventricular failure"
    ],
    "gold_answer": "Abnormal right ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06634",
    "question": "What is associated with Elevated mitochondrial citrate synthase activity?",
    "seeds": [
      "Elevated mitochondrial citrate synthase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06635",
    "question": "What is associated with IgA deposition in the glomerulus?",
    "seeds": [
      "IgA deposition in the glomerulus"
    ],
    "gold_answer": "Glomerular deposits",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06636",
    "question": "What is associated with Decreased CSF albumin concentration?",
    "seeds": [
      "Decreased CSF albumin concentration"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06637",
    "question": "What is associated with Adrenocorticotropin receptor defect?",
    "seeds": [
      "Adrenocorticotropin receptor defect"
    ],
    "gold_answer": "Central adrenal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06638",
    "question": "What is associated with Oromotor apraxia?",
    "seeds": [
      "Oromotor apraxia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06639",
    "question": "What is associated with Broad radius?",
    "seeds": [
      "Broad radius"
    ],
    "gold_answer": "Abnormal morphology of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06640",
    "question": "What is associated with Abnormal central microtubular pair morphology of respiratory motile cilia?",
    "seeds": [
      "Abnormal central microtubular pair morphology of respiratory motile cilia"
    ],
    "gold_answer": "Abnormal respiratory motile cilium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06641",
    "question": "What is associated with Focal aware emotional seizure?",
    "seeds": [
      "Focal aware emotional seizure"
    ],
    "gold_answer": "Focal aware non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06642",
    "question": "What is associated with Syncope?",
    "seeds": [
      "Syncope"
    ],
    "gold_answer": "Reduced consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06643",
    "question": "What is associated with Difficulty understanding humor?",
    "seeds": [
      "Difficulty understanding humor"
    ],
    "gold_answer": "Reduced social insight",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06644",
    "question": "What is associated with Spastic paraplegia-precocious puberty syndrome?",
    "seeds": [
      "Spastic paraplegia-precocious puberty syndrome"
    ],
    "gold_answer": "Abnormality of the Leydig cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06645",
    "question": "What is associated with Cone-Rod dystrophy 8?",
    "seeds": [
      "Cone-Rod dystrophy 8"
    ],
    "gold_answer": "Retinal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06646",
    "question": "What is associated with Absent patellar reflexes?",
    "seeds": [
      "Absent patellar reflexes"
    ],
    "gold_answer": "Areflexia of lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06647",
    "question": "What is associated with Abnormal ureter physiology?",
    "seeds": [
      "Abnormal ureter physiology"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06648",
    "question": "What is associated with Dwarfism, proportionate, with hip dislocation?",
    "seeds": [
      "Dwarfism, proportionate, with hip dislocation"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06649",
    "question": "What is associated with Narrow nasal tip?",
    "seeds": [
      "Narrow nasal tip"
    ],
    "gold_answer": "Abnormal nasal tip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06650",
    "question": "What is associated with Hypertriglyceridemia, familial?",
    "seeds": [
      "Hypertriglyceridemia, familial"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06651",
    "question": "What is associated with Abnormal drug response?",
    "seeds": [
      "Abnormal drug response"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06652",
    "question": "What is associated with Osteolytic defects of the middle phalanx of the 5th toe?",
    "seeds": [
      "Osteolytic defects of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Osteolysis involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06653",
    "question": "What is associated with Short first metatarsal?",
    "seeds": [
      "Short first metatarsal"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06654",
    "question": "What is associated with Reduced circulating interleukin 7 concentration?",
    "seeds": [
      "Reduced circulating interleukin 7 concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06655",
    "question": "What is associated with Fractured scapula?",
    "seeds": [
      "Fractured scapula"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06656",
    "question": "What is associated with Anti-rubella antibody positivity?",
    "seeds": [
      "Anti-rubella antibody positivity"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06657",
    "question": "What is associated with Yellow subcutaneous tissue covered by thin, scaly skin?",
    "seeds": [
      "Yellow subcutaneous tissue covered by thin, scaly skin"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06658",
    "question": "What is associated with Preimplantation embryonic lethality 2?",
    "seeds": [
      "Preimplantation embryonic lethality 2"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06659",
    "question": "What is associated with Low femoral bone density?",
    "seeds": [
      "Low femoral bone density"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06660",
    "question": "What is associated with Abnormality of masseter muscle?",
    "seeds": [
      "Abnormality of masseter muscle"
    ],
    "gold_answer": "Abnormality of masticatory muscle",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06661",
    "question": "What is associated with Absent nares?",
    "seeds": [
      "Absent nares"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06662",
    "question": "What is associated with Anti-cytomegalovirus antibody positivity?",
    "seeds": [
      "Anti-cytomegalovirus antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06663",
    "question": "What phenotype is associated with Atrial fibrillation, familial, 15?",
    "seeds": [
      "Atrial fibrillation, familial, 15"
    ],
    "gold_answer": "Atrial flutter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06664",
    "question": "What is associated with Cerebellar calcifications?",
    "seeds": [
      "Cerebellar calcifications"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06665",
    "question": "What is associated with Hypoplasia of the gallbladder?",
    "seeds": [
      "Hypoplasia of the gallbladder"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the gallbladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06666",
    "question": "What is associated with Short-Rib thoracic dysplasia 6 with or without polydactyly?",
    "seeds": [
      "Short-Rib thoracic dysplasia 6 with or without polydactyly"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06667",
    "question": "What is associated with Orbital margin, hypoplasia of?",
    "seeds": [
      "Orbital margin, hypoplasia of"
    ],
    "gold_answer": "Abnormality of the extraocular muscles",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06668",
    "question": "What is associated with Bronchomalacia?",
    "seeds": [
      "Bronchomalacia"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06669",
    "question": "What is associated with Agenesis of first permanent molar tooth?",
    "seeds": [
      "Agenesis of first permanent molar tooth"
    ],
    "gold_answer": "Abnormality of molar",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06670",
    "question": "What is associated with Cerebral cortical hemiatrophy?",
    "seeds": [
      "Cerebral cortical hemiatrophy"
    ],
    "gold_answer": "Cerebral atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06671",
    "question": "What is associated with T2 hypointense basal ganglia?",
    "seeds": [
      "T2 hypointense basal ganglia"
    ],
    "gold_answer": "Abnormal basal ganglia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06672",
    "question": "What is associated with Congenital plasminogen activator inhibitor type 1 deficiency?",
    "seeds": [
      "Congenital plasminogen activator inhibitor type 1 deficiency"
    ],
    "gold_answer": "Abnormality of the menstrual cycle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06673",
    "question": "What is associated with Fatty replacement of skeletal muscle?",
    "seeds": [
      "Fatty replacement of skeletal muscle"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06674",
    "question": "What is associated with Goldmann-Favre syndrome?",
    "seeds": [
      "Goldmann-Favre syndrome"
    ],
    "gold_answer": "NR2E3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06675",
    "question": "What is associated with Collagenoma, familial cutaneous?",
    "seeds": [
      "Collagenoma, familial cutaneous"
    ],
    "gold_answer": "Atrial arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06676",
    "question": "What is associated with Malaligned carpal bone?",
    "seeds": [
      "Malaligned carpal bone"
    ],
    "gold_answer": "Abnormal carpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06677",
    "question": "What is associated with Short 5th metacarpal?",
    "seeds": [
      "Short 5th metacarpal"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the 5th metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06678",
    "question": "What phenotype is associated with Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation"
    ],
    "gold_answer": "Flat occiput",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06679",
    "question": "What is associated with Elevated urinary saccharopine level?",
    "seeds": [
      "Elevated urinary saccharopine level"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06680",
    "question": "What is associated with Axillary epidermoid cyst?",
    "seeds": [
      "Axillary epidermoid cyst"
    ],
    "gold_answer": "Epidermoid cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06681",
    "question": "What is associated with Oocyte maturation defect 2?",
    "seeds": [
      "Oocyte maturation defect 2"
    ],
    "gold_answer": "Decreased fertility in females",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06682",
    "question": "What is associated with Absent internal genitalia?",
    "seeds": [
      "Absent internal genitalia"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06683",
    "question": "What is associated with Non-infectious meningitis?",
    "seeds": [
      "Non-infectious meningitis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06684",
    "question": "What is associated with Focal aware sensory seizure with auditory features?",
    "seeds": [
      "Focal aware sensory seizure with auditory features"
    ],
    "gold_answer": "Focal sensory seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06685",
    "question": "What is associated with Arteries, anomalies of?",
    "seeds": [
      "Arteries, anomalies of"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06686",
    "question": "What is associated with Isolated cerebellar agenesis?",
    "seeds": [
      "Isolated cerebellar agenesis"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06687",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 29?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 29"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06688",
    "question": "What is associated with Macule?",
    "seeds": [
      "Macule"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06689",
    "question": "What is associated with Respiratory failure?",
    "seeds": [
      "Respiratory failure"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06690",
    "question": "What is associated with Latent hypermetropia?",
    "seeds": [
      "Latent hypermetropia"
    ],
    "gold_answer": "Hypermetropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06691",
    "question": "What is associated with Autosomal recessive distal renal tubular acidosis?",
    "seeds": [
      "Autosomal recessive distal renal tubular acidosis"
    ],
    "gold_answer": "ATP6V1B1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06692",
    "question": "What is associated with Congenital disorder of glycosylation, type Ig?",
    "seeds": [
      "Congenital disorder of glycosylation, type Ig"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06693",
    "question": "What phenotype is associated with Retinitis pigmentosa 44?",
    "seeds": [
      "Retinitis pigmentosa 44"
    ],
    "gold_answer": "Attenuation of retinal blood vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06694",
    "question": "What is associated with Acanthosis nigricans?",
    "seeds": [
      "Acanthosis nigricans"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06695",
    "question": "What is associated with Enlarged epiphysis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Enlarged epiphysis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Enlarged epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06696",
    "question": "What is associated with Weight loss?",
    "seeds": [
      "Weight loss"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06697",
    "question": "What is associated with Nasolacrimal sac epithelial papillary carcinoma?",
    "seeds": [
      "Nasolacrimal sac epithelial papillary carcinoma"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06698",
    "question": "What is associated with Nodular neuronal heterotopia?",
    "seeds": [
      "Nodular neuronal heterotopia"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06699",
    "question": "What is associated with Palmoplantar keratoderma-deafness syndrome?",
    "seeds": [
      "Palmoplantar keratoderma-deafness syndrome"
    ],
    "gold_answer": "GJB2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06700",
    "question": "What is associated with Renal duplication?",
    "seeds": [
      "Renal duplication"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06701",
    "question": "What is associated with Decreased sensitivity to hypoxemia?",
    "seeds": [
      "Decreased sensitivity to hypoxemia"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06702",
    "question": "What is associated with Abnormal renal tubular epithelial morphology?",
    "seeds": [
      "Abnormal renal tubular epithelial morphology"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06703",
    "question": "What phenotype is associated with Familial atrial myxoma?",
    "seeds": [
      "Familial atrial myxoma"
    ],
    "gold_answer": "Pulmonic valve myxoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06704",
    "question": "What is associated with Symptomatic seizures?",
    "seeds": [
      "Symptomatic seizures"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06705",
    "question": "What is associated with Vaginal birth after Caesarean?",
    "seeds": [
      "Vaginal birth after Caesarean"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06706",
    "question": "What phenotype is associated with Spinocerebellar ataxia 49?",
    "seeds": [
      "Spinocerebellar ataxia 49"
    ],
    "gold_answer": "Cerebellar atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06707",
    "question": "What is associated with Insect allergy?",
    "seeds": [
      "Insect allergy"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06708",
    "question": "What phenotype is associated with Deafness, autosomal dominant nonsyndromic sensorineural 10?",
    "seeds": [
      "Deafness, autosomal dominant nonsyndromic sensorineural 10"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06709",
    "question": "What is associated with Arthrogryposis multiplex congenita 6?",
    "seeds": [
      "Arthrogryposis multiplex congenita 6"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06710",
    "question": "What is associated with Sarcoplasmic bodies?",
    "seeds": [
      "Sarcoplasmic bodies"
    ],
    "gold_answer": "Pathological inclusion body",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06711",
    "question": "What is associated with Absent brainstem auditory responses?",
    "seeds": [
      "Absent brainstem auditory responses"
    ],
    "gold_answer": "Abnormal brain-evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06712",
    "question": "What is associated with Esophageal hemangioma?",
    "seeds": [
      "Esophageal hemangioma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06713",
    "question": "What is associated with Epidermolysis bullosa, lethal acantholytic?",
    "seeds": [
      "Epidermolysis bullosa, lethal acantholytic"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06714",
    "question": "What is associated with Hepatic foam cells?",
    "seeds": [
      "Hepatic foam cells"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06715",
    "question": "What is associated with Triangular epiphysis of the distal phalanx of the 2nd finger?",
    "seeds": [
      "Triangular epiphysis of the distal phalanx of the 2nd finger"
    ],
    "gold_answer": "Triangular epiphyses of the distal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06716",
    "question": "What phenotype is associated with Temple-Baraitser syndrome?",
    "seeds": [
      "Temple-Baraitser syndrome"
    ],
    "gold_answer": "Proximal placement of thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06717",
    "question": "What is associated with Mobile lump?",
    "seeds": [
      "Mobile lump"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06718",
    "question": "What is associated with Abnormal lacrimal duct morphology?",
    "seeds": [
      "Abnormal lacrimal duct morphology"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06719",
    "question": "What is associated with STAG1-related intellectual disability-facial dysmorphism-gastroesophageal reflux syndrome?",
    "seeds": [
      "STAG1-related intellectual disability-facial dysmorphism-gastroesophageal reflux syndrome"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06720",
    "question": "What is associated with 1-3 toe syndactyly?",
    "seeds": [
      "1-3 toe syndactyly"
    ],
    "gold_answer": "Toe syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06721",
    "question": "What phenotype is associated with Cerebral cavernous malformations 2?",
    "seeds": [
      "Cerebral cavernous malformations 2"
    ],
    "gold_answer": "Cerebral hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06722",
    "question": "What is associated with Axenfeld anomaly?",
    "seeds": [
      "Axenfeld anomaly"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06723",
    "question": "What is associated with Cutis laxa, autosomal recessive, type IIIB?",
    "seeds": [
      "Cutis laxa, autosomal recessive, type IIIB"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06724",
    "question": "What is associated with Scimitar anomaly?",
    "seeds": [
      "Scimitar anomaly"
    ],
    "gold_answer": "Partial anomalous pulmonary venous return",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06725",
    "question": "What phenotype is associated with Lymphoblastic transformation, intrinsic defect in?",
    "seeds": [
      "Lymphoblastic transformation, intrinsic defect in"
    ],
    "gold_answer": "Abnormality of dental enamel",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06726",
    "question": "What is associated with Central nail canal?",
    "seeds": [
      "Central nail canal"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06727",
    "question": "What is associated with Abnormal penis morphology?",
    "seeds": [
      "Abnormal penis morphology"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06728",
    "question": "What is associated with Richieri Costa-da Silva syndrome?",
    "seeds": [
      "Richieri Costa-da Silva syndrome"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06729",
    "question": "What phenotype is associated with Ataxia, deafness, and cardiomyopathy?",
    "seeds": [
      "Ataxia, deafness, and cardiomyopathy"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06730",
    "question": "What is associated with Impaired renal tubular reabsorption of glucose?",
    "seeds": [
      "Impaired renal tubular reabsorption of glucose"
    ],
    "gold_answer": "Abnormal renal tubular resorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06731",
    "question": "What phenotype is associated with Hereditary neurocutaneous malformation?",
    "seeds": [
      "Hereditary neurocutaneous malformation"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06732",
    "question": "What is associated with Peroneal nerve, accessory deep?",
    "seeds": [
      "Peroneal nerve, accessory deep"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06733",
    "question": "What is associated with Ivory epiphysis of the distal phalanx of the hallux?",
    "seeds": [
      "Ivory epiphysis of the distal phalanx of the hallux"
    ],
    "gold_answer": "Ivory epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06734",
    "question": "What is associated with 11 pairs of ribs?",
    "seeds": [
      "11 pairs of ribs"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the ribs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06735",
    "question": "What is associated with Fanconi anemia, complementation group I?",
    "seeds": [
      "Fanconi anemia, complementation group I"
    ],
    "gold_answer": "Short long bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06736",
    "question": "What is associated with Aplasia of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Aplasia of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the proximal phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06737",
    "question": "What is associated with Cystinosis, late-onset juvenile or adolescent nephropathic?",
    "seeds": [
      "Cystinosis, late-onset juvenile or adolescent nephropathic"
    ],
    "gold_answer": "Corneal opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06738",
    "question": "What is associated with Reduced circulating interleukin 7 concentration?",
    "seeds": [
      "Reduced circulating interleukin 7 concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06739",
    "question": "What phenotype is associated with Tuberous sclerosis-1?",
    "seeds": [
      "Tuberous sclerosis-1"
    ],
    "gold_answer": "Angiofibromas",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06740",
    "question": "What is associated with Retinal flecks?",
    "seeds": [
      "Retinal flecks"
    ],
    "gold_answer": "Yellow/white retinal lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06741",
    "question": "What is associated with Decreased finger mobility?",
    "seeds": [
      "Decreased finger mobility"
    ],
    "gold_answer": "Abnormality of hand joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06742",
    "question": "What is associated with Myotonia fluctuans?",
    "seeds": [
      "Myotonia fluctuans"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06743",
    "question": "What is associated with Aplasia of the left hemidiaphragm?",
    "seeds": [
      "Aplasia of the left hemidiaphragm"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06744",
    "question": "What is associated with Focal aware autonomic seizure with pupillary dilation/constriction?",
    "seeds": [
      "Focal aware autonomic seizure with pupillary dilation/constriction"
    ],
    "gold_answer": "Focal autonomic seizure with pupillary dilation/constriction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06745",
    "question": "What is associated with Abnormal nasolabial region morphology?",
    "seeds": [
      "Abnormal nasolabial region morphology"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06746",
    "question": "What is associated with Intrahepatic biliary dysgenesis?",
    "seeds": [
      "Intrahepatic biliary dysgenesis"
    ],
    "gold_answer": "Abnormal biliary tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06747",
    "question": "What is associated with Cold-Induced sweating syndrome 2?",
    "seeds": [
      "Cold-Induced sweating syndrome 2"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06748",
    "question": "What is associated with Glaucoma 1, open angle, H?",
    "seeds": [
      "Glaucoma 1, open angle, H"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06749",
    "question": "What is associated with Infantile osteopetrosis with neuroaxonal dysplasia?",
    "seeds": [
      "Infantile osteopetrosis with neuroaxonal dysplasia"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06750",
    "question": "What is associated with Congenital patella dislocation?",
    "seeds": [
      "Congenital patella dislocation"
    ],
    "gold_answer": "Lower extremity joint dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06751",
    "question": "What is associated with Abnormal branching pattern of the aortic arch?",
    "seeds": [
      "Abnormal branching pattern of the aortic arch"
    ],
    "gold_answer": "Abnormal aortic arch morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06752",
    "question": "What is associated with Airway hyperresponsiveness?",
    "seeds": [
      "Airway hyperresponsiveness"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06753",
    "question": "What is associated with Seborrheic keratosis?",
    "seeds": [
      "Seborrheic keratosis"
    ],
    "gold_answer": "Neoplasm of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06754",
    "question": "What is associated with Oculocutaneous albinism type 5?",
    "seeds": [
      "Oculocutaneous albinism type 5"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06755",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 64?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 64"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06756",
    "question": "What is associated with Medial rectus muscle restriction?",
    "seeds": [
      "Medial rectus muscle restriction"
    ],
    "gold_answer": "Abnormal horizontal rectus muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06757",
    "question": "What is associated with Abnormal sialylation of O-linked protein glycosylation?",
    "seeds": [
      "Abnormal sialylation of O-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06758",
    "question": "What is associated with 12q14 microdeletion syndrome?",
    "seeds": [
      "12q14 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06759",
    "question": "What is associated with Prominent eyelashes?",
    "seeds": [
      "Prominent eyelashes"
    ],
    "gold_answer": "Abnormal eyelash morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06760",
    "question": "What is associated with Bilateral renal agenesis?",
    "seeds": [
      "Bilateral renal agenesis"
    ],
    "gold_answer": "Facial shape deformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06761",
    "question": "What is associated with Dysspondyloenchondromatosis?",
    "seeds": [
      "Dysspondyloenchondromatosis"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06762",
    "question": "What is associated with Cleft at the superior portion of the pinna?",
    "seeds": [
      "Cleft at the superior portion of the pinna"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06763",
    "question": "What is associated with Aplasia of the musculature of the pelvis?",
    "seeds": [
      "Aplasia of the musculature of the pelvis"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the musculature of the pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06764",
    "question": "What is associated with Amyoplasia?",
    "seeds": [
      "Amyoplasia"
    ],
    "gold_answer": "Aplasia of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06765",
    "question": "What is associated with Spinocerebellar ataxia 45?",
    "seeds": [
      "Spinocerebellar ataxia 45"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06766",
    "question": "What phenotype is associated with Temtamy syndrome?",
    "seeds": [
      "Temtamy syndrome"
    ],
    "gold_answer": "Thick corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06767",
    "question": "What is associated with Fish odor?",
    "seeds": [
      "Fish odor"
    ],
    "gold_answer": "Body odor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06768",
    "question": "What is associated with Biliary cirrhosis?",
    "seeds": [
      "Biliary cirrhosis"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06769",
    "question": "What phenotype is associated with Retinal degeneration, late-onset, autosomal dominant?",
    "seeds": [
      "Retinal degeneration, late-onset, autosomal dominant"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06770",
    "question": "What is associated with Third degree atrioventricular block?",
    "seeds": [
      "Third degree atrioventricular block"
    ],
    "gold_answer": "Abnormal atrioventricular conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06771",
    "question": "What is associated with Floating gallbladder?",
    "seeds": [
      "Floating gallbladder"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06772",
    "question": "What is associated with Difficulty standing?",
    "seeds": [
      "Difficulty standing"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06773",
    "question": "What phenotype is associated with Von willebrand disease, type 2?",
    "seeds": [
      "Von willebrand disease, type 2"
    ],
    "gold_answer": "Menorrhagia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06774",
    "question": "What is associated with Positive calf squeeze test?",
    "seeds": [
      "Positive calf squeeze test"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06775",
    "question": "What is associated with Jejunal adenocarcinoma?",
    "seeds": [
      "Jejunal adenocarcinoma"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06776",
    "question": "What is associated with 4-5 toe syndactyly?",
    "seeds": [
      "4-5 toe syndactyly"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06777",
    "question": "What is associated with Radioulnar synostosis with amegakaryocytic thrombocytopenia?",
    "seeds": [
      "Radioulnar synostosis with amegakaryocytic thrombocytopenia"
    ],
    "gold_answer": "Pancytopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06778",
    "question": "What is associated with Pontocerebellar hypoplasia, type 2E?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 2E"
    ],
    "gold_answer": "Abnormal emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06779",
    "question": "What is associated with Fingernail dysplasia?",
    "seeds": [
      "Fingernail dysplasia"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06780",
    "question": "What is associated with Broad uvula?",
    "seeds": [
      "Broad uvula"
    ],
    "gold_answer": "Abnormal uvula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06781",
    "question": "What is associated with Decrease in high molecular weight von Willebrand factor Multimers?",
    "seeds": [
      "Decrease in high molecular weight von Willebrand factor Multimers"
    ],
    "gold_answer": "Abnormality of von Willebrand factor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06782",
    "question": "What is associated with Ring chromosome 15 syndrome?",
    "seeds": [
      "Ring chromosome 15 syndrome"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06783",
    "question": "What is associated with Abnormal urine phosphate concentration?",
    "seeds": [
      "Abnormal urine phosphate concentration"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06784",
    "question": "What is associated with Transient erythroblastopenia of childhood?",
    "seeds": [
      "Transient erythroblastopenia of childhood"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06785",
    "question": "What phenotype is associated with Lissencephaly, X-linked, 1?",
    "seeds": [
      "Lissencephaly, X-linked, 1"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06786",
    "question": "What is associated with Basal ganglia calcification, idiopathic, 6?",
    "seeds": [
      "Basal ganglia calcification, idiopathic, 6"
    ],
    "gold_answer": "Abnormal basal ganglia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06787",
    "question": "What is associated with Deletion 5q35 syndrome?",
    "seeds": [
      "Deletion 5q35 syndrome"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06788",
    "question": "What is associated with Abnormal location of the eyebrow?",
    "seeds": [
      "Abnormal location of the eyebrow"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06789",
    "question": "What is associated with Wide cavum septum pellucidum?",
    "seeds": [
      "Wide cavum septum pellucidum"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06790",
    "question": "What is associated with Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits?",
    "seeds": [
      "Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06791",
    "question": "What is associated with Decreased esterified to free carnitine ratio?",
    "seeds": [
      "Decreased esterified to free carnitine ratio"
    ],
    "gold_answer": "Abnormal esterified to free carnitine ratio",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06792",
    "question": "What is associated with Interlobular vein intima/media multilamellation?",
    "seeds": [
      "Interlobular vein intima/media multilamellation"
    ],
    "gold_answer": "Abnormal interlobular vein intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06793",
    "question": "What is associated with Miliary?",
    "seeds": [
      "Miliary"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06794",
    "question": "What is associated with Polymicrogyria, bilateral frontoparietal?",
    "seeds": [
      "Polymicrogyria, bilateral frontoparietal"
    ],
    "gold_answer": "Clonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06795",
    "question": "What phenotype is associated with SLC35A2-CDG?",
    "seeds": [
      "SLC35A2-CDG"
    ],
    "gold_answer": "Paroxysmal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06796",
    "question": "What is associated with Superficial dermal perivascular inflammatory infiltrate?",
    "seeds": [
      "Superficial dermal perivascular inflammatory infiltrate"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06797",
    "question": "What is associated with Oligodontia of primary teeth?",
    "seeds": [
      "Oligodontia of primary teeth"
    ],
    "gold_answer": "Abnormal oral physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06798",
    "question": "What is associated with Pendred syndrome?",
    "seeds": [
      "Pendred syndrome"
    ],
    "gold_answer": "Neoplasm of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06799",
    "question": "What is associated with Delayed fine motor development?",
    "seeds": [
      "Delayed fine motor development"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06800",
    "question": "What phenotype is associated with Autosomal recessive ataxia, Beauce type?",
    "seeds": [
      "Autosomal recessive ataxia, Beauce type"
    ],
    "gold_answer": "Impaired smooth pursuit",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06801",
    "question": "What is associated with Intratubular myoglobin cast?",
    "seeds": [
      "Intratubular myoglobin cast"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06802",
    "question": "What is associated with Craniofacial osteosclerosis?",
    "seeds": [
      "Craniofacial osteosclerosis"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06803",
    "question": "What is associated with Multiple epiphyseal dysplasia type 1?",
    "seeds": [
      "Multiple epiphyseal dysplasia type 1"
    ],
    "gold_answer": "Abnormality of the calf",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06804",
    "question": "What is associated with Decreased coracohumeral distance?",
    "seeds": [
      "Decreased coracohumeral distance"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06805",
    "question": "What phenotype is associated with Holoprosencephaly-craniosynostosis syndrome?",
    "seeds": [
      "Holoprosencephaly-craniosynostosis syndrome"
    ],
    "gold_answer": "Hydrocephalus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06806",
    "question": "What is associated with Supracardiac total anomalous pulmonary venous connection?",
    "seeds": [
      "Supracardiac total anomalous pulmonary venous connection"
    ],
    "gold_answer": "Total anomalous pulmonary venous return",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06807",
    "question": "What is associated with Midnasal atresia?",
    "seeds": [
      "Midnasal atresia"
    ],
    "gold_answer": "Midnasal stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06808",
    "question": "What is associated with Distal widening of metacarpals?",
    "seeds": [
      "Distal widening of metacarpals"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06809",
    "question": "What is associated with Toe phalanx fracture?",
    "seeds": [
      "Toe phalanx fracture"
    ],
    "gold_answer": "Fractured hindlimb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06810",
    "question": "What is associated with Decreased number of vertebrae?",
    "seeds": [
      "Decreased number of vertebrae"
    ],
    "gold_answer": "Abnormal number of vertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06811",
    "question": "What is associated with Corneal stromal edema?",
    "seeds": [
      "Corneal stromal edema"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06812",
    "question": "What is associated with Foot pain?",
    "seeds": [
      "Foot pain"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06813",
    "question": "What is associated with Abnormal lymph node cell composition?",
    "seeds": [
      "Abnormal lymph node cell composition"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06814",
    "question": "What is associated with Paget disease of bone 2, early-onset?",
    "seeds": [
      "Paget disease of bone 2, early-onset"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06815",
    "question": "What is associated with Dysplastic sacrum?",
    "seeds": [
      "Dysplastic sacrum"
    ],
    "gold_answer": "Abnormal sacrum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06816",
    "question": "What phenotype is associated with 3-methylglutaconic aciduria, type V?",
    "seeds": [
      "3-methylglutaconic aciduria, type V"
    ],
    "gold_answer": "Mild intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06817",
    "question": "What is associated with Hyperphalangy of the 3rd finger?",
    "seeds": [
      "Hyperphalangy of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06818",
    "question": "What phenotype is associated with Holoprosencephaly 7?",
    "seeds": [
      "Holoprosencephaly 7"
    ],
    "gold_answer": "Flat face",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06819",
    "question": "What is associated with Nijmegen breakage syndrome-like disorder?",
    "seeds": [
      "Nijmegen breakage syndrome-like disorder"
    ],
    "gold_answer": "Abnormal B cell physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06820",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 23?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 23"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06821",
    "question": "What is associated with Macular scar?",
    "seeds": [
      "Macular scar"
    ],
    "gold_answer": "Scarring",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06822",
    "question": "What is associated with Abnormal pectoral muscle morphology?",
    "seeds": [
      "Abnormal pectoral muscle morphology"
    ],
    "gold_answer": "Abnormality of the musculature of the thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06823",
    "question": "What phenotype is associated with Nephronophthisis 13?",
    "seeds": [
      "Nephronophthisis 13"
    ],
    "gold_answer": "Renal hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06824",
    "question": "What is associated with X-linked dominant chondrodysplasia punctata?",
    "seeds": [
      "X-linked dominant chondrodysplasia punctata"
    ],
    "gold_answer": "Cephalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06825",
    "question": "What is associated with Limb dystonia?",
    "seeds": [
      "Limb dystonia"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06826",
    "question": "What phenotype is associated with Macular dystrophy, butterfly-shaped pigmentary, 2?",
    "seeds": [
      "Macular dystrophy, butterfly-shaped pigmentary, 2"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06827",
    "question": "What is associated with Bilateral superior vena cava with bridging vein?",
    "seeds": [
      "Bilateral superior vena cava with bridging vein"
    ],
    "gold_answer": "Abnormal superior vena cava morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06828",
    "question": "What is associated with Recurrent patellar dislocation?",
    "seeds": [
      "Recurrent patellar dislocation"
    ],
    "gold_answer": "Abnormal knee morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06829",
    "question": "What is associated with Facial myokymia?",
    "seeds": [
      "Facial myokymia"
    ],
    "gold_answer": "Abnormality of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06830",
    "question": "What is associated with Bouchard node?",
    "seeds": [
      "Bouchard node"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06831",
    "question": "What is associated with Femoral osteopoikilosis?",
    "seeds": [
      "Femoral osteopoikilosis"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06832",
    "question": "What is associated with Pendular nystagmus?",
    "seeds": [
      "Pendular nystagmus"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06833",
    "question": "What is associated with Foveal hyporeflective spaces on macular OCT?",
    "seeds": [
      "Foveal hyporeflective spaces on macular OCT"
    ],
    "gold_answer": "Abnormal foveal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06834",
    "question": "What is associated with Abnormal Humphrey SITA 10-2 perimetry test?",
    "seeds": [
      "Abnormal Humphrey SITA 10-2 perimetry test"
    ],
    "gold_answer": "Abnormal static perimetry test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06835",
    "question": "What is associated with Chronic lactic acidosis?",
    "seeds": [
      "Chronic lactic acidosis"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06836",
    "question": "What is associated with Corpus callosum agenesis-macrocephaly-hypertelorism syndrome?",
    "seeds": [
      "Corpus callosum agenesis-macrocephaly-hypertelorism syndrome"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06837",
    "question": "What is associated with Abnormal renal calyx morphology?",
    "seeds": [
      "Abnormal renal calyx morphology"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06838",
    "question": "What phenotype is associated with Duodenal ulcer, hyperpepsinogenemic I?",
    "seeds": [
      "Duodenal ulcer, hyperpepsinogenemic I"
    ],
    "gold_answer": "Duodenal ulcer",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06839",
    "question": "What is associated with Congenital disorder of glycosylation, type IIB?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIB"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06840",
    "question": "What is associated with Trisomy 4p syndrome?",
    "seeds": [
      "Trisomy 4p syndrome"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06841",
    "question": "What is associated with Fragmentation of thumb epiphysis?",
    "seeds": [
      "Fragmentation of thumb epiphysis"
    ],
    "gold_answer": "Fragmented upper limb epiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06842",
    "question": "What phenotype is associated with Dystonia 15, myoclonic?",
    "seeds": [
      "Dystonia 15, myoclonic"
    ],
    "gold_answer": "Dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06843",
    "question": "What is associated with Aminopterin syndrome sine aminopterin?",
    "seeds": [
      "Aminopterin syndrome sine aminopterin"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06844",
    "question": "What is associated with Glomerular subendothelial widening?",
    "seeds": [
      "Glomerular subendothelial widening"
    ],
    "gold_answer": "Abnormal glomerular basement membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06845",
    "question": "What is associated with Abnormal blood monovalent inorganic cation concentration?",
    "seeds": [
      "Abnormal blood monovalent inorganic cation concentration"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06846",
    "question": "What is associated with Hypoplasia of the dental root?",
    "seeds": [
      "Hypoplasia of the dental root"
    ],
    "gold_answer": "Abnormal dental morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06847",
    "question": "What is associated with Duplication of middle phalanx of toe?",
    "seeds": [
      "Duplication of middle phalanx of toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06848",
    "question": "What phenotype is associated with X-linked neurodegenerative syndrome, Hamel type?",
    "seeds": [
      "X-linked neurodegenerative syndrome, Hamel type"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06849",
    "question": "What is associated with Post-vaccination polio?",
    "seeds": [
      "Post-vaccination polio"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06850",
    "question": "What is associated with Abnormal memory T cell proportion?",
    "seeds": [
      "Abnormal memory T cell proportion"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06851",
    "question": "What is associated with Peripheral cone dystrophy?",
    "seeds": [
      "Peripheral cone dystrophy"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06852",
    "question": "What is associated with Joubert syndrome 27?",
    "seeds": [
      "Joubert syndrome 27"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06853",
    "question": "What is associated with Stenosis of the Eustachian tube?",
    "seeds": [
      "Stenosis of the Eustachian tube"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06854",
    "question": "What is associated with Anti-histone antibody positivity?",
    "seeds": [
      "Anti-histone antibody positivity"
    ],
    "gold_answer": "Antinuclear antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06855",
    "question": "What is associated with Triangular epiphysis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Triangular epiphysis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Triangular epiphyses of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06856",
    "question": "What phenotype is associated with Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies, somatic mosaic?",
    "seeds": [
      "Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies, somatic mosaic"
    ],
    "gold_answer": "Persistence of primary teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06857",
    "question": "What is associated with Dependency on parenteral nutrition?",
    "seeds": [
      "Dependency on parenteral nutrition"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06858",
    "question": "What is associated with Increased level of galactitol in plasma?",
    "seeds": [
      "Increased level of galactitol in plasma"
    ],
    "gold_answer": "Abnormal circulating carbohydrate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06859",
    "question": "What phenotype is associated with Language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia?",
    "seeds": [
      "Language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia"
    ],
    "gold_answer": "Bradycardia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06860",
    "question": "What is associated with Posteriorly placed tongue?",
    "seeds": [
      "Posteriorly placed tongue"
    ],
    "gold_answer": "Abnormality of the mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06861",
    "question": "What is associated with Chiari type III malformation?",
    "seeds": [
      "Chiari type III malformation"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06862",
    "question": "What phenotype is associated with Prader-Willi syndrome?",
    "seeds": [
      "Prader-Willi syndrome"
    ],
    "gold_answer": "Acromicria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06863",
    "question": "What is associated with Epidermolysis bullosa simplex with muscular dystrophy?",
    "seeds": [
      "Epidermolysis bullosa simplex with muscular dystrophy"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06864",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 58?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 58"
    ],
    "gold_answer": "Obstructive sleep apnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06865",
    "question": "What is associated with Positive bursa fluid gram stain?",
    "seeds": [
      "Positive bursa fluid gram stain"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06866",
    "question": "What is associated with Sinus node disease and myopia?",
    "seeds": [
      "Sinus node disease and myopia"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06867",
    "question": "What is associated with Spondylometaphyseal dysplasia, 'corner fracture' type?",
    "seeds": [
      "Spondylometaphyseal dysplasia, 'corner fracture' type"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06868",
    "question": "What is associated with Elevated circulating CK-MB concentration?",
    "seeds": [
      "Elevated circulating CK-MB concentration"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06869",
    "question": "What is associated with Elevated CSF neopterin level?",
    "seeds": [
      "Elevated CSF neopterin level"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06870",
    "question": "What is associated with Ovarian dysgenesis 1?",
    "seeds": [
      "Ovarian dysgenesis 1"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06871",
    "question": "What is associated with Elevated urinary vanillylmandelic acid?",
    "seeds": [
      "Elevated urinary vanillylmandelic acid"
    ],
    "gold_answer": "Aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06872",
    "question": "What is associated with Biceps areflexia?",
    "seeds": [
      "Biceps areflexia"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06873",
    "question": "What is associated with Bronchial atresia?",
    "seeds": [
      "Bronchial atresia"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06874",
    "question": "What phenotype is associated with Spinocerebellar ataxia, X-linked 2?",
    "seeds": [
      "Spinocerebellar ataxia, X-linked 2"
    ],
    "gold_answer": "Abnormality of extrapyramidal motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06875",
    "question": "What is associated with Left anterior fascicular block?",
    "seeds": [
      "Left anterior fascicular block"
    ],
    "gold_answer": "Left bundle branch block",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06876",
    "question": "What is associated with Muscle glycogenosis, X-linked?",
    "seeds": [
      "Muscle glycogenosis, X-linked"
    ],
    "gold_answer": "Proximal muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06877",
    "question": "What is associated with Craniosynostosis 2?",
    "seeds": [
      "Craniosynostosis 2"
    ],
    "gold_answer": "Abnormal frontal bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06878",
    "question": "What phenotype is associated with Congenital disorder of glycosylation type 1EE with or without immunodeficiency?",
    "seeds": [
      "Congenital disorder of glycosylation type 1EE with or without immunodeficiency"
    ],
    "gold_answer": "Decreased total lymphocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06879",
    "question": "What is associated with History of recent viral illness?",
    "seeds": [
      "History of recent viral illness"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06880",
    "question": "What is associated with Hyaline membranes?",
    "seeds": [
      "Hyaline membranes"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06881",
    "question": "What is associated with Stickler syndrome type 1?",
    "seeds": [
      "Stickler syndrome type 1"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06882",
    "question": "What is associated with Abnormal glomerular capillary morphology?",
    "seeds": [
      "Abnormal glomerular capillary morphology"
    ],
    "gold_answer": "Abnormal renal cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06883",
    "question": "What is associated with Central retinal vein occlusion?",
    "seeds": [
      "Central retinal vein occlusion"
    ],
    "gold_answer": "Fundus hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06884",
    "question": "What is associated with Localized to the penis?",
    "seeds": [
      "Localized to the penis"
    ],
    "gold_answer": "Localized",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06885",
    "question": "What is associated with Paronychia?",
    "seeds": [
      "Paronychia"
    ],
    "gold_answer": "Abnormal periungual morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06886",
    "question": "What is associated with Abnormal humeral epiphysis morphology?",
    "seeds": [
      "Abnormal humeral epiphysis morphology"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06887",
    "question": "What is associated with Spinal muscular atrophy, segmental?",
    "seeds": [
      "Spinal muscular atrophy, segmental"
    ],
    "gold_answer": "Abnormality of the musculature of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06888",
    "question": "What is associated with Varus instability of the elbow?",
    "seeds": [
      "Varus instability of the elbow"
    ],
    "gold_answer": "Elbow instability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06889",
    "question": "What is associated with Increased HDL3c concentration?",
    "seeds": [
      "Increased HDL3c concentration"
    ],
    "gold_answer": "Abnormal HDL subfraction concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06890",
    "question": "What is associated with Two carpal ossification centers present at birth?",
    "seeds": [
      "Two carpal ossification centers present at birth"
    ],
    "gold_answer": "Abnormal hand bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06891",
    "question": "What is associated with Abnormal blood chloride concentration?",
    "seeds": [
      "Abnormal blood chloride concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06892",
    "question": "What is associated with Infratentorial superficial CNS hemosiderin deposition?",
    "seeds": [
      "Infratentorial superficial CNS hemosiderin deposition"
    ],
    "gold_answer": "Superficial CNS hemosiderin deposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06893",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 3?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 3"
    ],
    "gold_answer": "Lower limb amyotrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06894",
    "question": "What is associated with Neurodevelopmental disorder with poor growth, absent speech, progressive ataxia, and dysmorphic facies?",
    "seeds": [
      "Neurodevelopmental disorder with poor growth, absent speech, progressive ataxia, and dysmorphic facies"
    ],
    "gold_answer": "Talipes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06895",
    "question": "What is associated with Anterior chamber cells?",
    "seeds": [
      "Anterior chamber cells"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06896",
    "question": "What is associated with Primitive reflex?",
    "seeds": [
      "Primitive reflex"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06897",
    "question": "What is associated with Partial atrioventricular septal defect without ventricular hypoplasia?",
    "seeds": [
      "Partial atrioventricular septal defect without ventricular hypoplasia"
    ],
    "gold_answer": "CRELD1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_06898",
    "question": "What is associated with Idiopathic juvenile osteoporosis?",
    "seeds": [
      "Idiopathic juvenile osteoporosis"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06899",
    "question": "What is associated with Premature ovarian insufficiency?",
    "seeds": [
      "Premature ovarian insufficiency"
    ],
    "gold_answer": "Abnormal ovarian physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06900",
    "question": "What is associated with Lung fibroma?",
    "seeds": [
      "Lung fibroma"
    ],
    "gold_answer": "Neoplasm of the lung",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06901",
    "question": "What is associated with Craniosynostosis 2?",
    "seeds": [
      "Craniosynostosis 2"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06902",
    "question": "What is associated with Increased incisura length?",
    "seeds": [
      "Increased incisura length"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06903",
    "question": "What is associated with Aplasia of the 2nd finger?",
    "seeds": [
      "Aplasia of the 2nd finger"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06904",
    "question": "What is associated with Drowsiness?",
    "seeds": [
      "Drowsiness"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06905",
    "question": "What phenotype is associated with Deafness, autosomal dominant 65?",
    "seeds": [
      "Deafness, autosomal dominant 65"
    ],
    "gold_answer": "Progressive hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06906",
    "question": "What is associated with Tremor, hereditary essential, 4?",
    "seeds": [
      "Tremor, hereditary essential, 4"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06907",
    "question": "What is associated with Usher syndrome type 3?",
    "seeds": [
      "Usher syndrome type 3"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06908",
    "question": "What is associated with Reduced tissue delta-1-pyrroline-5-carboxylate dehydrogenase activity?",
    "seeds": [
      "Reduced tissue delta-1-pyrroline-5-carboxylate dehydrogenase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06909",
    "question": "What is associated with Congenital hypertrophy of retinal pigment epithelium?",
    "seeds": [
      "Congenital hypertrophy of retinal pigment epithelium"
    ],
    "gold_answer": "Abnormal fundus pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06910",
    "question": "What is associated with Poor recognition of injustice?",
    "seeds": [
      "Poor recognition of injustice"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06911",
    "question": "What is associated with Acrokeratosis verruciformis of Hopf?",
    "seeds": [
      "Acrokeratosis verruciformis of Hopf"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06912",
    "question": "What is associated with Abnormal nipple morphology?",
    "seeds": [
      "Abnormal nipple morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06913",
    "question": "What is associated with Posterior vertebral body notching?",
    "seeds": [
      "Posterior vertebral body notching"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06914",
    "question": "What is associated with Congenital autosomal recessive small-platelet thrombocytopenia?",
    "seeds": [
      "Congenital autosomal recessive small-platelet thrombocytopenia"
    ],
    "gold_answer": "FYB1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06915",
    "question": "What is associated with Hyperpigmented genitalia?",
    "seeds": [
      "Hyperpigmented genitalia"
    ],
    "gold_answer": "Abnormal genital pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06916",
    "question": "What is associated with Peripheral neuropathy, ataxia, focal necrotizing encephalopathy, and?",
    "seeds": [
      "Peripheral neuropathy, ataxia, focal necrotizing encephalopathy, and"
    ],
    "gold_answer": "Peripheral neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06917",
    "question": "What is associated with Temporal cortical atrophy?",
    "seeds": [
      "Temporal cortical atrophy"
    ],
    "gold_answer": "Cerebral atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06918",
    "question": "What is associated with Radial head subluxation?",
    "seeds": [
      "Radial head subluxation"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06919",
    "question": "What is associated with Spastic paraplegia 52, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 52, autosomal recessive"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06920",
    "question": "What is associated with Abnormal pulmonary interstitial morphology?",
    "seeds": [
      "Abnormal pulmonary interstitial morphology"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06921",
    "question": "What is associated with Abnormal cerebral vein morphology?",
    "seeds": [
      "Abnormal cerebral vein morphology"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06922",
    "question": "What is associated with Muscle fiber polyglucosan inclusion bodies?",
    "seeds": [
      "Muscle fiber polyglucosan inclusion bodies"
    ],
    "gold_answer": "Muscle fiber inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06923",
    "question": "What is associated with Meckel syndrome 13?",
    "seeds": [
      "Meckel syndrome 13"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06924",
    "question": "What is associated with Cardiac hemangioma?",
    "seeds": [
      "Cardiac hemangioma"
    ],
    "gold_answer": "Vascular neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06925",
    "question": "What is associated with Elevated CSF alpha-ketoglutarate concentration?",
    "seeds": [
      "Elevated CSF alpha-ketoglutarate concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06926",
    "question": "What is associated with Impaired cytokine signaling?",
    "seeds": [
      "Impaired cytokine signaling"
    ],
    "gold_answer": "Abnormal cytokine signaling",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06927",
    "question": "What is associated with Alcohol sensitivity, acute?",
    "seeds": [
      "Alcohol sensitivity, acute"
    ],
    "gold_answer": "Flushing",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06928",
    "question": "What is associated with Small epiphysis of the proximal phalanx of the hallux?",
    "seeds": [
      "Small epiphysis of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06929",
    "question": "What is associated with Neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06930",
    "question": "What is associated with X-linked adrenal hypoplasia congenita?",
    "seeds": [
      "X-linked adrenal hypoplasia congenita"
    ],
    "gold_answer": "Abnormality of the adrenal glands",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06931",
    "question": "What is associated with Decreased naive CD4+ T cell proportion?",
    "seeds": [
      "Decreased naive CD4+ T cell proportion"
    ],
    "gold_answer": "Abnormal naive CD4+ T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06932",
    "question": "What is associated with Night blindness, congenital stationary, type 1I?",
    "seeds": [
      "Night blindness, congenital stationary, type 1I"
    ],
    "gold_answer": "Anomalous trichromacy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06933",
    "question": "What is associated with Calcium oxalate crystalluria?",
    "seeds": [
      "Calcium oxalate crystalluria"
    ],
    "gold_answer": "Crystalluria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06934",
    "question": "What is associated with Reduced circulating vitamin B6 circulating?",
    "seeds": [
      "Reduced circulating vitamin B6 circulating"
    ],
    "gold_answer": "Abnormal circulating vitamin B6 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06935",
    "question": "What is associated with Coronary artery aneurysm?",
    "seeds": [
      "Coronary artery aneurysm"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06936",
    "question": "What is associated with Fatiguable weakness of proximal limb muscles?",
    "seeds": [
      "Fatiguable weakness of proximal limb muscles"
    ],
    "gold_answer": "Abnormal synaptic transmission at the neuromuscular junction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06937",
    "question": "What is associated with Renal tubular dysfunction?",
    "seeds": [
      "Renal tubular dysfunction"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06938",
    "question": "What is associated with Falciform retinal fold?",
    "seeds": [
      "Falciform retinal fold"
    ],
    "gold_answer": "Retinal fold",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06939",
    "question": "What is associated with Body odor?",
    "seeds": [
      "Body odor"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06940",
    "question": "What is associated with Upper extremity akinesia?",
    "seeds": [
      "Upper extremity akinesia"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06941",
    "question": "What phenotype is associated with Primary angiitis of the central nervous system?",
    "seeds": [
      "Primary angiitis of the central nervous system"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06942",
    "question": "What is associated with Inferior pubic ramus hypoplasia?",
    "seeds": [
      "Inferior pubic ramus hypoplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the pubic bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06943",
    "question": "What is associated with Floating-Harbor syndrome?",
    "seeds": [
      "Floating-Harbor syndrome"
    ],
    "gold_answer": "Abnormal dental enamel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06944",
    "question": "What is associated with Optic neuropathy?",
    "seeds": [
      "Optic neuropathy"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06945",
    "question": "What is associated with Short proximal phalanx of the 2nd toe?",
    "seeds": [
      "Short proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Absent toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06946",
    "question": "What is associated with Anti-salivary protein antibody positivity?",
    "seeds": [
      "Anti-salivary protein antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06947",
    "question": "What phenotype is associated with Epidermolysis bullosa acquisita?",
    "seeds": [
      "Epidermolysis bullosa acquisita"
    ],
    "gold_answer": "Atypical scarring of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06948",
    "question": "What is associated with Decreased mixed venous oxygen saturation?",
    "seeds": [
      "Decreased mixed venous oxygen saturation"
    ],
    "gold_answer": "Abnormal mixed venous oxygen saturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06949",
    "question": "What is associated with Forward facing earlobe?",
    "seeds": [
      "Forward facing earlobe"
    ],
    "gold_answer": "Abnormal earlobe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06950",
    "question": "What is associated with Lipodystrophy?",
    "seeds": [
      "Lipodystrophy"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06951",
    "question": "What is associated with Absent epiphysis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Absent epiphysis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06952",
    "question": "What phenotype is associated with Rothmund-Thomson syndrome?",
    "seeds": [
      "Rothmund-Thomson syndrome"
    ],
    "gold_answer": "Cellulitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06953",
    "question": "What is associated with Testicular torsion?",
    "seeds": [
      "Testicular torsion"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06954",
    "question": "What phenotype is associated with Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction?",
    "seeds": [
      "Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06955",
    "question": "What is associated with Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome?",
    "seeds": [
      "Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome"
    ],
    "gold_answer": "TKFC",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06956",
    "question": "What is associated with Extrahepatic portal hypertension?",
    "seeds": [
      "Extrahepatic portal hypertension"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06957",
    "question": "What is associated with Recurrent infections?",
    "seeds": [
      "Recurrent infections"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06958",
    "question": "What is associated with Dry skin?",
    "seeds": [
      "Dry skin"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06959",
    "question": "What is associated with Epidermolytic hyperkeratosis 2B, autosomal recessive?",
    "seeds": [
      "Epidermolytic hyperkeratosis 2B, autosomal recessive"
    ],
    "gold_answer": "ALOX12B",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_06960",
    "question": "What phenotype is associated with SATB2-associated syndrome due to a chromosomal rearrangement?",
    "seeds": [
      "SATB2-associated syndrome due to a chromosomal rearrangement"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06961",
    "question": "What is associated with Anti-factor H antibody positivity?",
    "seeds": [
      "Anti-factor H antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06962",
    "question": "What phenotype is associated with Intellectual disability-muscle weakness-short stature-facial dysmorphism syndrome?",
    "seeds": [
      "Intellectual disability-muscle weakness-short stature-facial dysmorphism syndrome"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06963",
    "question": "What is associated with Absent vestibular function?",
    "seeds": [
      "Absent vestibular function"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06964",
    "question": "What is associated with Prostate mass?",
    "seeds": [
      "Prostate mass"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06965",
    "question": "What phenotype is associated with Neurodevelopmental disorder with or without seizures and gait abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with or without seizures and gait abnormalities"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06966",
    "question": "What phenotype is associated with Trichorhinophalangeal syndrome type 1?",
    "seeds": [
      "Trichorhinophalangeal syndrome type 1"
    ],
    "gold_answer": "Fragile nails",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06967",
    "question": "What is associated with Isolated absence of upper arm and forearm with hand present?",
    "seeds": [
      "Isolated absence of upper arm and forearm with hand present"
    ],
    "gold_answer": "Abnormal bladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06968",
    "question": "What is associated with Abnormal CSF serine concentration?",
    "seeds": [
      "Abnormal CSF serine concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06969",
    "question": "What phenotype is associated with Subacute cutaneous lupus erythematosus?",
    "seeds": [
      "Subacute cutaneous lupus erythematosus"
    ],
    "gold_answer": "Annular cutaneous lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06970",
    "question": "What is associated with 9q21.13 microdeletion syndrome?",
    "seeds": [
      "9q21.13 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06971",
    "question": "What is associated with Interlobular vein medial hypertrophy?",
    "seeds": [
      "Interlobular vein medial hypertrophy"
    ],
    "gold_answer": "Abnormal interlobular vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06972",
    "question": "What phenotype is associated with Familial hyperaldosteronism type I?",
    "seeds": [
      "Familial hyperaldosteronism type I"
    ],
    "gold_answer": "Dexamethasone-suppresible primary hyperaldosteronism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06973",
    "question": "What is associated with Livedo racemosa?",
    "seeds": [
      "Livedo racemosa"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06974",
    "question": "What is associated with Zygotic cleavage failure?",
    "seeds": [
      "Zygotic cleavage failure"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06975",
    "question": "What is associated with Reduced muscle fiber lamin A/C?",
    "seeds": [
      "Reduced muscle fiber lamin A/C"
    ],
    "gold_answer": "Abnormal muscle fiber protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06976",
    "question": "What is associated with Cervical ribs?",
    "seeds": [
      "Cervical ribs"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06977",
    "question": "What is associated with Elevated hemoglobin A1c?",
    "seeds": [
      "Elevated hemoglobin A1c"
    ],
    "gold_answer": "Abnormal hemoglobin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06978",
    "question": "What is associated with Abnormal thalamic size?",
    "seeds": [
      "Abnormal thalamic size"
    ],
    "gold_answer": "Abnormal diencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06979",
    "question": "What is associated with Ivory epiphysis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Ivory epiphysis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Ivory epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06980",
    "question": "What is associated with Reduced radioactive iodine uptake?",
    "seeds": [
      "Reduced radioactive iodine uptake"
    ],
    "gold_answer": "Abnormal radioactive iodine uptake test result",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06981",
    "question": "What phenotype is associated with Dosage-Sensitive sex reversal?",
    "seeds": [
      "Dosage-Sensitive sex reversal"
    ],
    "gold_answer": "Sex reversal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06982",
    "question": "What is associated with Hemophagocytic syndrome associated with an infection?",
    "seeds": [
      "Hemophagocytic syndrome associated with an infection"
    ],
    "gold_answer": "Abnormal total neutrophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06983",
    "question": "What is associated with Congenital myopathy 28 with rigid spine?",
    "seeds": [
      "Congenital myopathy 28 with rigid spine"
    ],
    "gold_answer": "Abnormal scapula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06984",
    "question": "What is associated with Spermatocele?",
    "seeds": [
      "Spermatocele"
    ],
    "gold_answer": "Abnormal epididymis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06985",
    "question": "What is associated with Glutaric acidemia type 3?",
    "seeds": [
      "Glutaric acidemia type 3"
    ],
    "gold_answer": "Dicarboxylic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06986",
    "question": "What phenotype is associated with Hypogonadotropic hypogonadism 10 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 10 with or without anosmia"
    ],
    "gold_answer": "Decreased serum testosterone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06987",
    "question": "What is associated with Sphincter of Oddi dyskinesia?",
    "seeds": [
      "Sphincter of Oddi dyskinesia"
    ],
    "gold_answer": "Biliary dyskinesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06988",
    "question": "What phenotype is associated with Cortical dysplasia, complex, with other brain malformations 9?",
    "seeds": [
      "Cortical dysplasia, complex, with other brain malformations 9"
    ],
    "gold_answer": "Reduced cerebral white matter volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_06989",
    "question": "What is associated with Angiomatosis, diffuse corticomeningeal, of divry and van bogaert?",
    "seeds": [
      "Angiomatosis, diffuse corticomeningeal, of divry and van bogaert"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06990",
    "question": "What is associated with Decreased circulating fetuin A concentration?",
    "seeds": [
      "Decreased circulating fetuin A concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06991",
    "question": "What is associated with Abnormal neuron branching?",
    "seeds": [
      "Abnormal neuron branching"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06992",
    "question": "What is associated with Abnormality of tensor veli palatini muscle?",
    "seeds": [
      "Abnormality of tensor veli palatini muscle"
    ],
    "gold_answer": "Abnormal soft palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06993",
    "question": "What is associated with Iga nephropathy, susceptibility to, 3?",
    "seeds": [
      "Iga nephropathy, susceptibility to, 3"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06994",
    "question": "What is associated with Facial wrinkling?",
    "seeds": [
      "Facial wrinkling"
    ],
    "gold_answer": "Prematurely aged appearance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06995",
    "question": "What is associated with Lateral thrust?",
    "seeds": [
      "Lateral thrust"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06996",
    "question": "What is associated with Cataract, anterior polar, 1?",
    "seeds": [
      "Cataract, anterior polar, 1"
    ],
    "gold_answer": "Polar cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06997",
    "question": "What is associated with Increased length of the tibia?",
    "seeds": [
      "Increased length of the tibia"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06998",
    "question": "What is associated with Abnormal hallux morphology?",
    "seeds": [
      "Abnormal hallux morphology"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_06999",
    "question": "What is associated with Lacunar stroke?",
    "seeds": [
      "Lacunar stroke"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07000",
    "question": "What is associated with Myoclonus, intractable, neonatal?",
    "seeds": [
      "Myoclonus, intractable, neonatal"
    ],
    "gold_answer": "Cerebral ischemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07001",
    "question": "What is associated with Chronic lymphocytic meningitis?",
    "seeds": [
      "Chronic lymphocytic meningitis"
    ],
    "gold_answer": "Meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07002",
    "question": "What is associated with Aplasia/Hypoplasia of the liver?",
    "seeds": [
      "Aplasia/Hypoplasia of the liver"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07003",
    "question": "What is associated with Abnormal palm morphology?",
    "seeds": [
      "Abnormal palm morphology"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07004",
    "question": "What is associated with Saccadic oscillation?",
    "seeds": [
      "Saccadic oscillation"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07005",
    "question": "What is associated with Bone marrow failure syndrome 4?",
    "seeds": [
      "Bone marrow failure syndrome 4"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07006",
    "question": "What is associated with Frequent falls?",
    "seeds": [
      "Frequent falls"
    ],
    "gold_answer": "Functional motor deficit",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07007",
    "question": "What is associated with Retinopathy, pericentral pigmentary, dominant?",
    "seeds": [
      "Retinopathy, pericentral pigmentary, dominant"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07008",
    "question": "What is associated with Birk-Barel syndrome?",
    "seeds": [
      "Birk-Barel syndrome"
    ],
    "gold_answer": "Peripheral axonal neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07009",
    "question": "What is associated with Abnormality of the lymphatic system?",
    "seeds": [
      "Abnormality of the lymphatic system"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07010",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 7?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 7"
    ],
    "gold_answer": "Tetraplegia/tetraparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07011",
    "question": "What is associated with Diffuse hepatic steatosis?",
    "seeds": [
      "Diffuse hepatic steatosis"
    ],
    "gold_answer": "Lipid accumulation in hepatocytes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07012",
    "question": "What is associated with Multiple tumor-associated chromosome region 1?",
    "seeds": [
      "Multiple tumor-associated chromosome region 1"
    ],
    "gold_answer": "Displacement of the urethral meatus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07013",
    "question": "What is associated with Broad radial metaphysis?",
    "seeds": [
      "Broad radial metaphysis"
    ],
    "gold_answer": "Abnormal radial metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07014",
    "question": "What is associated with Iron-Refractory iron deficiency anemia?",
    "seeds": [
      "Iron-Refractory iron deficiency anemia"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07015",
    "question": "What is associated with Familial pseudohyperkalemia?",
    "seeds": [
      "Familial pseudohyperkalemia"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07016",
    "question": "What is associated with Flat face-microstomia-ear anomaly syndrome?",
    "seeds": [
      "Flat face-microstomia-ear anomaly syndrome"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07017",
    "question": "What is associated with Osteolytic defects of the phalanges of the 4th finger?",
    "seeds": [
      "Osteolytic defects of the phalanges of the 4th finger"
    ],
    "gold_answer": "Osteolytic defects of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07018",
    "question": "What is associated with Recurrent aphthous stomatitis?",
    "seeds": [
      "Recurrent aphthous stomatitis"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07019",
    "question": "What is associated with Increased body weight?",
    "seeds": [
      "Increased body weight"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07020",
    "question": "What is associated with Aplasia of the maxilla?",
    "seeds": [
      "Aplasia of the maxilla"
    ],
    "gold_answer": "Aplasia/Hypoplasia of facial bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07021",
    "question": "What is associated with Pierre-Robin sequence?",
    "seeds": [
      "Pierre-Robin sequence"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07022",
    "question": "What is associated with Joint laxity, short stature, and myopia?",
    "seeds": [
      "Joint laxity, short stature, and myopia"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07023",
    "question": "What is associated with Wild type ATTR amyloidosis?",
    "seeds": [
      "Wild type ATTR amyloidosis"
    ],
    "gold_answer": "Impaired continence",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07024",
    "question": "What is associated with Acrokeratosis verruciformis?",
    "seeds": [
      "Acrokeratosis verruciformis"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07025",
    "question": "What is associated with Prenatal death?",
    "seeds": [
      "Prenatal death"
    ],
    "gold_answer": "Clinical course",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07026",
    "question": "What is associated with Decreased circulating C1q concentration?",
    "seeds": [
      "Decreased circulating C1q concentration"
    ],
    "gold_answer": "Reduced circulating complement concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07027",
    "question": "What is associated with Abnormal circulating protein concentration?",
    "seeds": [
      "Abnormal circulating protein concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07028",
    "question": "What is associated with Brachydactyly type A1?",
    "seeds": [
      "Brachydactyly type A1"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07029",
    "question": "What is associated with Waardenburg-Shah syndrome?",
    "seeds": [
      "Waardenburg-Shah syndrome"
    ],
    "gold_answer": "Prematurely aged appearance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07030",
    "question": "What phenotype is associated with Sporadic fetal brain disruption sequence?",
    "seeds": [
      "Sporadic fetal brain disruption sequence"
    ],
    "gold_answer": "Intellectual disability, progressive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07031",
    "question": "What phenotype is associated with Intellectual developmental disorder and microcephaly with pontine and cerebellar hypoplasia?",
    "seeds": [
      "Intellectual developmental disorder and microcephaly with pontine and cerebellar hypoplasia"
    ],
    "gold_answer": "Dilated fourth ventricle",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07032",
    "question": "What phenotype is associated with Diarrhea 7, protein-losing Enteropathy type?",
    "seeds": [
      "Diarrhea 7, protein-losing Enteropathy type"
    ],
    "gold_answer": "Hyperlipidemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07033",
    "question": "What is associated with Microcephaly, cataracts, impaired intellectual development, and dystonia with abnormal striatum?",
    "seeds": [
      "Microcephaly, cataracts, impaired intellectual development, and dystonia with abnormal striatum"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07034",
    "question": "What is associated with Warburg micro syndrome 1?",
    "seeds": [
      "Warburg micro syndrome 1"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07035",
    "question": "What is associated with Hyperdense pulmonary mass?",
    "seeds": [
      "Hyperdense pulmonary mass"
    ],
    "gold_answer": "Abnormal pulmonary thoracic imaging finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07036",
    "question": "What is associated with Increased vertical cup-to-disc ratio - 1.0?",
    "seeds": [
      "Increased vertical cup-to-disc ratio - 1.0"
    ],
    "gold_answer": "Increased cup-to-disc ratio",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07037",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 58?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 58"
    ],
    "gold_answer": "Aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07038",
    "question": "What is associated with Abnormal morphology of myocardial trabeculae?",
    "seeds": [
      "Abnormal morphology of myocardial trabeculae"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07039",
    "question": "What is associated with Abnormal synovial bursa morphology?",
    "seeds": [
      "Abnormal synovial bursa morphology"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07040",
    "question": "What is associated with Absent fetal nasal bone?",
    "seeds": [
      "Absent fetal nasal bone"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07041",
    "question": "What is associated with Simplified gyral pattern?",
    "seeds": [
      "Simplified gyral pattern"
    ],
    "gold_answer": "Abnormal cortical gyration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07042",
    "question": "What is associated with Retinopathy of prematurity stage 2?",
    "seeds": [
      "Retinopathy of prematurity stage 2"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07043",
    "question": "What is associated with Elevated circulating beta-CTX concentration?",
    "seeds": [
      "Elevated circulating beta-CTX concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07044",
    "question": "What is associated with Placidity?",
    "seeds": [
      "Placidity"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07045",
    "question": "What is associated with Myotonic dystrophy 1?",
    "seeds": [
      "Myotonic dystrophy 1"
    ],
    "gold_answer": "Brain atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07046",
    "question": "What is associated with Abnormality of the face?",
    "seeds": [
      "Abnormality of the face"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07047",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 67?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 67"
    ],
    "gold_answer": "Myoclonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07048",
    "question": "What is associated with Forward facing earlobe?",
    "seeds": [
      "Forward facing earlobe"
    ],
    "gold_answer": "Abnormal earlobe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07049",
    "question": "What phenotype is associated with Cholestasis, progressive familial intrahepatic, 8?",
    "seeds": [
      "Cholestasis, progressive familial intrahepatic, 8"
    ],
    "gold_answer": "Increased serum bile acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07050",
    "question": "What is associated with Reading-induced seizure?",
    "seeds": [
      "Reading-induced seizure"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07051",
    "question": "What is associated with Epidermolysis bullosa, junctional 2B, severe?",
    "seeds": [
      "Epidermolysis bullosa, junctional 2B, severe"
    ],
    "gold_answer": "Blistering by anatomical location",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07052",
    "question": "What is associated with Increased circulating insulin-like growth factor 1 concentration?",
    "seeds": [
      "Increased circulating insulin-like growth factor 1 concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07053",
    "question": "What is associated with Dermatochalasis?",
    "seeds": [
      "Dermatochalasis"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07054",
    "question": "What is associated with Thrombocytopenia-absent radius syndrome?",
    "seeds": [
      "Thrombocytopenia-absent radius syndrome"
    ],
    "gold_answer": "Abnormal 5th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07055",
    "question": "What is associated with Autonomic bladder dysfunction?",
    "seeds": [
      "Autonomic bladder dysfunction"
    ],
    "gold_answer": "Abnormality of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07056",
    "question": "What phenotype is associated with Stevenson-Carey syndrome?",
    "seeds": [
      "Stevenson-Carey syndrome"
    ],
    "gold_answer": "Recurrent urinary tract infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07057",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 51?",
    "seeds": [
      "Ciliary dyskinesia, primary, 51"
    ],
    "gold_answer": "Hydrocephalus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07058",
    "question": "What is associated with Arthrogryposis and ectodermal dysplasia?",
    "seeds": [
      "Arthrogryposis and ectodermal dysplasia"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07059",
    "question": "What is associated with Acute disseminated encephalomyelitis?",
    "seeds": [
      "Acute disseminated encephalomyelitis"
    ],
    "gold_answer": "Abnormal CNS myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07060",
    "question": "What is associated with Decreased total B cell count?",
    "seeds": [
      "Decreased total B cell count"
    ],
    "gold_answer": "Abnormal B cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07061",
    "question": "What is associated with Multicentric ossification of proximal femoral epiphyses?",
    "seeds": [
      "Multicentric ossification of proximal femoral epiphyses"
    ],
    "gold_answer": "Abnormal enchondral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07062",
    "question": "What is associated with Robin sequence, distinctive facial appearance, and brachydactyly?",
    "seeds": [
      "Robin sequence, distinctive facial appearance, and brachydactyly"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the nails",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07063",
    "question": "What is associated with Myopathy and diabetes mellitus?",
    "seeds": [
      "Myopathy and diabetes mellitus"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07064",
    "question": "What is associated with Absent upper eyelashes?",
    "seeds": [
      "Absent upper eyelashes"
    ],
    "gold_answer": "Abnormal eyelash morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07065",
    "question": "What is associated with Abnormality of the hip-girdle musculature?",
    "seeds": [
      "Abnormality of the hip-girdle musculature"
    ],
    "gold_answer": "Abnormal morphology of the pelvis musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07066",
    "question": "What is associated with Abnormal location of ears?",
    "seeds": [
      "Abnormal location of ears"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07067",
    "question": "What is associated with Polydactyly, postaxial, type A2?",
    "seeds": [
      "Polydactyly, postaxial, type A2"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07068",
    "question": "What is associated with Odontochondrodysplasia?",
    "seeds": [
      "Odontochondrodysplasia"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07069",
    "question": "What is associated with Tobacco use history?",
    "seeds": [
      "Tobacco use history"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07070",
    "question": "What is associated with Congenital heart defects and ectodermal dysplasia?",
    "seeds": [
      "Congenital heart defects and ectodermal dysplasia"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07071",
    "question": "What is associated with Abnormal platelet function?",
    "seeds": [
      "Abnormal platelet function"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07072",
    "question": "What is associated with Elevated circulating carcinoma antigen 125 concentration?",
    "seeds": [
      "Elevated circulating carcinoma antigen 125 concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07073",
    "question": "What is associated with Fibular deviation of the 3rd toe?",
    "seeds": [
      "Fibular deviation of the 3rd toe"
    ],
    "gold_answer": "Deviation of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07074",
    "question": "What is associated with Oculocutaneous albinism type 5?",
    "seeds": [
      "Oculocutaneous albinism type 5"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07075",
    "question": "What is associated with Calcium carbonate crystalluria?",
    "seeds": [
      "Calcium carbonate crystalluria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07076",
    "question": "What phenotype is associated with Neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima?",
    "seeds": [
      "Neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima"
    ],
    "gold_answer": "Abnormal circulating adrenocorticotropin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07077",
    "question": "What is associated with Charcot-Marie-Tooth disease, dominant intermediate G?",
    "seeds": [
      "Charcot-Marie-Tooth disease, dominant intermediate G"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07078",
    "question": "What is associated with DK1-CDG?",
    "seeds": [
      "DK1-CDG"
    ],
    "gold_answer": "Abnormal cardiomyocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07079",
    "question": "What is associated with Optic atrophy 6?",
    "seeds": [
      "Optic atrophy 6"
    ],
    "gold_answer": "Abnormal optic disc morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07080",
    "question": "What is associated with Multiple enchondromatosis, Maffucci type?",
    "seeds": [
      "Multiple enchondromatosis, Maffucci type"
    ],
    "gold_answer": "EXT1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "candidate_gene_tested_in"
    }
  },
  {
    "query_id": "orph_train_07081",
    "question": "What is associated with ALK-positive anaplastic large cell lymphoma?",
    "seeds": [
      "ALK-positive anaplastic large cell lymphoma"
    ],
    "gold_answer": "ALK",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07082",
    "question": "What is associated with Spinocerebellar ataxia type 21?",
    "seeds": [
      "Spinocerebellar ataxia type 21"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07083",
    "question": "What is associated with Asymmetry of the mouth?",
    "seeds": [
      "Asymmetry of the mouth"
    ],
    "gold_answer": "Abnormality of mouth shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07084",
    "question": "What is associated with Abnormal substantia nigra morphology?",
    "seeds": [
      "Abnormal substantia nigra morphology"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07085",
    "question": "What phenotype is associated with Neurodevelopmental disorder with or without anomalies of the brain, eye, or heart?",
    "seeds": [
      "Neurodevelopmental disorder with or without anomalies of the brain, eye, or heart"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07086",
    "question": "What is associated with Focal cortical dysplasia type Ia?",
    "seeds": [
      "Focal cortical dysplasia type Ia"
    ],
    "gold_answer": "Focal cortical dysplasia type I",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07087",
    "question": "What is associated with Decreased platelet glycoprotein VI?",
    "seeds": [
      "Decreased platelet glycoprotein VI"
    ],
    "gold_answer": "Abnormal platelet membrane protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07088",
    "question": "What is associated with Reduced circulating lactate dehydrogenase concentration?",
    "seeds": [
      "Reduced circulating lactate dehydrogenase concentration"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07089",
    "question": "What is associated with Abnormal respiratory system morphology?",
    "seeds": [
      "Abnormal respiratory system morphology"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07090",
    "question": "What is associated with Painless mass?",
    "seeds": [
      "Painless mass"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07091",
    "question": "What is associated with Stippling of the epiphysis of the proximal phalanx of the hallux?",
    "seeds": [
      "Stippling of the epiphysis of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07092",
    "question": "What is associated with Orofaciodigital syndrome XIV?",
    "seeds": [
      "Orofaciodigital syndrome XIV"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07093",
    "question": "What is associated with Reduced phosphoserine phosphatase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced phosphoserine phosphatase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal enzyme activity in cultured fibroblasts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07094",
    "question": "What is associated with Abnormal dental root morphology?",
    "seeds": [
      "Abnormal dental root morphology"
    ],
    "gold_answer": "Abnormal dental morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07095",
    "question": "What is associated with Increased ratio of VWF propeptide to VWF antigen?",
    "seeds": [
      "Increased ratio of VWF propeptide to VWF antigen"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07096",
    "question": "What is associated with Severe platyspondyly?",
    "seeds": [
      "Severe platyspondyly"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07097",
    "question": "What is associated with Late first trimester onset?",
    "seeds": [
      "Late first trimester onset"
    ],
    "gold_answer": "Fetal onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07098",
    "question": "What phenotype is associated with Neutropenia, chronic familial?",
    "seeds": [
      "Neutropenia, chronic familial"
    ],
    "gold_answer": "Clubbing of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07099",
    "question": "What is associated with Maternal diabetes?",
    "seeds": [
      "Maternal diabetes"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07100",
    "question": "What is associated with Ocular motor apraxia?",
    "seeds": [
      "Ocular motor apraxia"
    ],
    "gold_answer": "Apraxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07101",
    "question": "What is associated with Progressive myoclonic epilepsy type 8?",
    "seeds": [
      "Progressive myoclonic epilepsy type 8"
    ],
    "gold_answer": "CERS1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07102",
    "question": "What is associated with Ataxia-oculomotor apraxia type 1?",
    "seeds": [
      "Ataxia-oculomotor apraxia type 1"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07103",
    "question": "What is associated with Absent nasal cartilage?",
    "seeds": [
      "Absent nasal cartilage"
    ],
    "gold_answer": "Abnormal nasal cartilage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07104",
    "question": "What is associated with Posterior fossa mass lesion?",
    "seeds": [
      "Posterior fossa mass lesion"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07105",
    "question": "What phenotype is associated with Spinocerebellar ataxia type 14?",
    "seeds": [
      "Spinocerebellar ataxia type 14"
    ],
    "gold_answer": "Saccadic smooth pursuit",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07106",
    "question": "What is associated with Joubert syndrome 37?",
    "seeds": [
      "Joubert syndrome 37"
    ],
    "gold_answer": "Abnormal frontal bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07107",
    "question": "What is associated with Decreased anti-CD3/28-induced T-cell proliferation?",
    "seeds": [
      "Decreased anti-CD3/28-induced T-cell proliferation"
    ],
    "gold_answer": "Abnormal T cell physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07108",
    "question": "What is associated with Retinal telangiectasia?",
    "seeds": [
      "Retinal telangiectasia"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07109",
    "question": "What is associated with Adenocarcinoma of the small intestine?",
    "seeds": [
      "Adenocarcinoma of the small intestine"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07110",
    "question": "What is associated with Wide radioulnar joints?",
    "seeds": [
      "Wide radioulnar joints"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07111",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 30?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 30"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07112",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the thumb?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Sclerosis of middle phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07113",
    "question": "What is associated with Spinal muscular atrophy?",
    "seeds": [
      "Spinal muscular atrophy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07114",
    "question": "What is associated with Multiple rib fractures?",
    "seeds": [
      "Multiple rib fractures"
    ],
    "gold_answer": "Abnormal rib morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07115",
    "question": "What is associated with Balanitis?",
    "seeds": [
      "Balanitis"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07116",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, demyelinating, type 1J?",
    "seeds": [
      "Charcot-Marie-Tooth disease, demyelinating, type 1J"
    ],
    "gold_answer": "Decreased motor nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07117",
    "question": "What is associated with Anti-Kelch like protein 11 antibody positivity?",
    "seeds": [
      "Anti-Kelch like protein 11 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07118",
    "question": "What is associated with Speech apraxia?",
    "seeds": [
      "Speech apraxia"
    ],
    "gold_answer": "Apraxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07119",
    "question": "What phenotype is associated with 6-pyruvoyl-tetrahydropterin synthase deficiency?",
    "seeds": [
      "6-pyruvoyl-tetrahydropterin synthase deficiency"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07120",
    "question": "What is associated with Congenitally uncorrected transposition of the great arteries with cardiac malformation?",
    "seeds": [
      "Congenitally uncorrected transposition of the great arteries with cardiac malformation"
    ],
    "gold_answer": "CFC1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "candidate_gene_tested_in"
    }
  },
  {
    "query_id": "orph_train_07121",
    "question": "What is associated with Abnormal transitional B cell proportion?",
    "seeds": [
      "Abnormal transitional B cell proportion"
    ],
    "gold_answer": "Abnormal B cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07122",
    "question": "What is associated with Posterior corneal stroma punctiform multicolored opacities?",
    "seeds": [
      "Posterior corneal stroma punctiform multicolored opacities"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07123",
    "question": "What is associated with CLOVES syndrome?",
    "seeds": [
      "CLOVES syndrome"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07124",
    "question": "What is associated with Hip flexor weakness?",
    "seeds": [
      "Hip flexor weakness"
    ],
    "gold_answer": "Limb-girdle muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07125",
    "question": "What is associated with Discrete fundus hypopigmentation?",
    "seeds": [
      "Discrete fundus hypopigmentation"
    ],
    "gold_answer": "Fundus hypopigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07126",
    "question": "What is associated with Lymphatic malformation 3?",
    "seeds": [
      "Lymphatic malformation 3"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07127",
    "question": "What is associated with Broad-based gait?",
    "seeds": [
      "Broad-based gait"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07128",
    "question": "What is associated with Nodular melanoma?",
    "seeds": [
      "Nodular melanoma"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07129",
    "question": "What is associated with Superior rectus atrophy?",
    "seeds": [
      "Superior rectus atrophy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07130",
    "question": "What is associated with Elevated urinary cytidine?",
    "seeds": [
      "Elevated urinary cytidine"
    ],
    "gold_answer": "Abnormal urinary pyrimidine level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07131",
    "question": "What is associated with Focal aware cognitive seizure with conduction dysphasia/aphasia?",
    "seeds": [
      "Focal aware cognitive seizure with conduction dysphasia/aphasia"
    ],
    "gold_answer": "Focal aware seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07132",
    "question": "What is associated with Metaphyseal chondromatosis of humerus?",
    "seeds": [
      "Metaphyseal chondromatosis of humerus"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07133",
    "question": "What is associated with Median pseudocleft lip?",
    "seeds": [
      "Median pseudocleft lip"
    ],
    "gold_answer": "Abnormal upper lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07134",
    "question": "What is associated with Corneal dystrophy, Fuchs endothelial, 4?",
    "seeds": [
      "Corneal dystrophy, Fuchs endothelial, 4"
    ],
    "gold_answer": "Abnormal corneal endothelium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07135",
    "question": "What is associated with Absent nasal septal cartilage?",
    "seeds": [
      "Absent nasal septal cartilage"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07136",
    "question": "What is associated with Preretinal hemorrhage?",
    "seeds": [
      "Preretinal hemorrhage"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07137",
    "question": "What is associated with Charcot-Marie-Tooth disease, dominant intermediate E?",
    "seeds": [
      "Charcot-Marie-Tooth disease, dominant intermediate E"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07138",
    "question": "What is associated with Dementia?",
    "seeds": [
      "Dementia"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07139",
    "question": "What is associated with Melanoma, uveal, susceptibility to, 2?",
    "seeds": [
      "Melanoma, uveal, susceptibility to, 2"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07140",
    "question": "What is associated with Oligodontia of primary teeth?",
    "seeds": [
      "Oligodontia of primary teeth"
    ],
    "gold_answer": "Oligodontia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07141",
    "question": "What is associated with Hypoketotic hypoglycemia?",
    "seeds": [
      "Hypoketotic hypoglycemia"
    ],
    "gold_answer": "Abnormal blood glucose concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07142",
    "question": "What is associated with Decreased CSF N-acetyl-aspartyl-glutamate concentration?",
    "seeds": [
      "Decreased CSF N-acetyl-aspartyl-glutamate concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07143",
    "question": "What is associated with Increased red blood cell count?",
    "seeds": [
      "Increased red blood cell count"
    ],
    "gold_answer": "Abnormal red blood cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07144",
    "question": "What is associated with Intellectual developmental disorder with seizures and language delay?",
    "seeds": [
      "Intellectual developmental disorder with seizures and language delay"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07145",
    "question": "What is associated with Cataract 1, multiple types?",
    "seeds": [
      "Cataract 1, multiple types"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07146",
    "question": "What is associated with ANOSMIA?",
    "seeds": [
      "ANOSMIA"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07147",
    "question": "What is associated with Usher syndrome, type IIC?",
    "seeds": [
      "Usher syndrome, type IIC"
    ],
    "gold_answer": "Retinal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07148",
    "question": "What is associated with Oculopharyngodistal myopathy?",
    "seeds": [
      "Oculopharyngodistal myopathy"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07149",
    "question": "What is associated with Abnormal pancreatic acinus morphology?",
    "seeds": [
      "Abnormal pancreatic acinus morphology"
    ],
    "gold_answer": "Abnormal pancreas morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07150",
    "question": "What is associated with Pai syndrome?",
    "seeds": [
      "Pai syndrome"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07151",
    "question": "What is associated with Epilepsy, familial temporal lobe, 4?",
    "seeds": [
      "Epilepsy, familial temporal lobe, 4"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07152",
    "question": "What is associated with Agenesis of lateral incisor?",
    "seeds": [
      "Agenesis of lateral incisor"
    ],
    "gold_answer": "Abnormal number of incisors",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07153",
    "question": "What is associated with Modic type III vertebral endplate changes?",
    "seeds": [
      "Modic type III vertebral endplate changes"
    ],
    "gold_answer": "Modic type vertebral endplate changes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07154",
    "question": "What is associated with Woronets trait?",
    "seeds": [
      "Woronets trait"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07155",
    "question": "What is associated with Fanconi anemia, complementation group V?",
    "seeds": [
      "Fanconi anemia, complementation group V"
    ],
    "gold_answer": "Abnormal circulating alpha-fetoprotein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07156",
    "question": "What is associated with Nasolacrimal sac obstruction?",
    "seeds": [
      "Nasolacrimal sac obstruction"
    ],
    "gold_answer": "Abnormal lacrimal sac morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07157",
    "question": "What is associated with Paroxysmal rectal pain?",
    "seeds": [
      "Paroxysmal rectal pain"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07158",
    "question": "What is associated with Fragmentation of the epiphyses of the 4th finger?",
    "seeds": [
      "Fragmentation of the epiphyses of the 4th finger"
    ],
    "gold_answer": "Abnormal hand epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07159",
    "question": "What is associated with Plaque-form urticaria pigmentosa?",
    "seeds": [
      "Plaque-form urticaria pigmentosa"
    ],
    "gold_answer": "KIT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07160",
    "question": "What is associated with Hypocapnia in cord blood?",
    "seeds": [
      "Hypocapnia in cord blood"
    ],
    "gold_answer": "Abnormal cord blood measurement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07161",
    "question": "What is associated with Nephronophthisis 18?",
    "seeds": [
      "Nephronophthisis 18"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07162",
    "question": "What is associated with Diminishment of sexual behavior?",
    "seeds": [
      "Diminishment of sexual behavior"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07163",
    "question": "What is associated with Diabetes mellitus, insulin-dependent, 15?",
    "seeds": [
      "Diabetes mellitus, insulin-dependent, 15"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07164",
    "question": "What is associated with Abnormal hematocrit?",
    "seeds": [
      "Abnormal hematocrit"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07165",
    "question": "What is associated with Curved phalanges of the hand?",
    "seeds": [
      "Curved phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07166",
    "question": "What is associated with Mitochondrial complex V (ATP synthase) deficiency, nuclear type 2?",
    "seeds": [
      "Mitochondrial complex V (ATP synthase) deficiency, nuclear type 2"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07167",
    "question": "What phenotype is associated with Myasthenic syndrome, congenital, 25, presynaptic?",
    "seeds": [
      "Myasthenic syndrome, congenital, 25, presynaptic"
    ],
    "gold_answer": "Severe muscular hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07168",
    "question": "What is associated with Positive Coombs test?",
    "seeds": [
      "Positive Coombs test"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07169",
    "question": "What is associated with Paraseptal?",
    "seeds": [
      "Paraseptal"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07170",
    "question": "What is associated with Torsion of appendix of testis?",
    "seeds": [
      "Torsion of appendix of testis"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07171",
    "question": "What is associated with Fanconi anemia, complementation group O?",
    "seeds": [
      "Fanconi anemia, complementation group O"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07172",
    "question": "What is associated with Anti-lamin C antibody positivity?",
    "seeds": [
      "Anti-lamin C antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07173",
    "question": "What is associated with Abnormality of the gastrointestinal tract?",
    "seeds": [
      "Abnormality of the gastrointestinal tract"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07174",
    "question": "What phenotype is associated with VACTERL with hydrocephalus?",
    "seeds": [
      "VACTERL with hydrocephalus"
    ],
    "gold_answer": "Morphological abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07175",
    "question": "What phenotype is associated with Variegate porphyria, childhood-onset?",
    "seeds": [
      "Variegate porphyria, childhood-onset"
    ],
    "gold_answer": "Fragile skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07176",
    "question": "What is associated with Decreased acrosin in sperm head?",
    "seeds": [
      "Decreased acrosin in sperm head"
    ],
    "gold_answer": "Abnormal sperm head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07177",
    "question": "What is associated with Retinal astrocytic hamartoma?",
    "seeds": [
      "Retinal astrocytic hamartoma"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07178",
    "question": "What is associated with Bracket epiphysis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Bracket epiphysis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07179",
    "question": "What is associated with Fractured proximal epiphysis of middle phalanx of manual digit 3?",
    "seeds": [
      "Fractured proximal epiphysis of middle phalanx of manual digit 3"
    ],
    "gold_answer": "Fragmentation of the epiphyses of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07180",
    "question": "What is associated with Hermansky-Pudlak syndrome 9?",
    "seeds": [
      "Hermansky-Pudlak syndrome 9"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07181",
    "question": "What phenotype is associated with Congenitally corrected transposition of the great arteries?",
    "seeds": [
      "Congenitally corrected transposition of the great arteries"
    ],
    "gold_answer": "Pulmonary artery stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07182",
    "question": "What is associated with Proximal spinal muscular atrophy type 4?",
    "seeds": [
      "Proximal spinal muscular atrophy type 4"
    ],
    "gold_answer": "SMN1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07183",
    "question": "What is associated with Cholestasis, progressive familial intrahepatic 2?",
    "seeds": [
      "Cholestasis, progressive familial intrahepatic 2"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07184",
    "question": "What is associated with Reduced proximal interphalangeal joint space?",
    "seeds": [
      "Reduced proximal interphalangeal joint space"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07185",
    "question": "What is associated with Enlarged epiphysis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Enlarged epiphysis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07186",
    "question": "What phenotype is associated with Acrokeratoelastoidosis of Costa?",
    "seeds": [
      "Acrokeratoelastoidosis of Costa"
    ],
    "gold_answer": "Skin plaque",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07187",
    "question": "What is associated with Absent cavum septum pellucidum?",
    "seeds": [
      "Absent cavum septum pellucidum"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07188",
    "question": "What phenotype is associated with Alagille syndrome 2?",
    "seeds": [
      "Alagille syndrome 2"
    ],
    "gold_answer": "Cholestatic liver disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07189",
    "question": "What is associated with Xanthinuria?",
    "seeds": [
      "Xanthinuria"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07190",
    "question": "What is associated with Motor tics?",
    "seeds": [
      "Motor tics"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07191",
    "question": "What is associated with Focal behavior arrest seizure?",
    "seeds": [
      "Focal behavior arrest seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07192",
    "question": "What is associated with Hepatitis?",
    "seeds": [
      "Hepatitis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07193",
    "question": "What is associated with Delayed tarsal ossification?",
    "seeds": [
      "Delayed tarsal ossification"
    ],
    "gold_answer": "Abnormality of the tarsal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07194",
    "question": "What is associated with Reduced red cell pyruvate kinase level?",
    "seeds": [
      "Reduced red cell pyruvate kinase level"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07195",
    "question": "What is associated with Retinal arteriolar occlusion?",
    "seeds": [
      "Retinal arteriolar occlusion"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07196",
    "question": "What is associated with Anti-glomerular basement membrane disease?",
    "seeds": [
      "Anti-glomerular basement membrane disease"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07197",
    "question": "What is associated with Viral hepatitis?",
    "seeds": [
      "Viral hepatitis"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07198",
    "question": "What is associated with Essential fructosuria?",
    "seeds": [
      "Essential fructosuria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07199",
    "question": "What is associated with Transient decreased circulating IgG3?",
    "seeds": [
      "Transient decreased circulating IgG3"
    ],
    "gold_answer": "Decreased circulating IgG3 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07200",
    "question": "What phenotype is associated with Parkinson disease 13?",
    "seeds": [
      "Parkinson disease 13"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07201",
    "question": "What is associated with Hypotonia, ataxia, and delayed development syndrome?",
    "seeds": [
      "Hypotonia, ataxia, and delayed development syndrome"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07202",
    "question": "What is associated with Absent knee epiphyses?",
    "seeds": [
      "Absent knee epiphyses"
    ],
    "gold_answer": "Absent epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07203",
    "question": "What is associated with Enlarged amygdala?",
    "seeds": [
      "Enlarged amygdala"
    ],
    "gold_answer": "Abnormal amygdala morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07204",
    "question": "What is associated with Osteopathia striata?",
    "seeds": [
      "Osteopathia striata"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07205",
    "question": "What is associated with Keratoconjunctivitis sicca?",
    "seeds": [
      "Keratoconjunctivitis sicca"
    ],
    "gold_answer": "Keratoconjunctivitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07206",
    "question": "What is associated with Prolonged bleeding time?",
    "seeds": [
      "Prolonged bleeding time"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07207",
    "question": "What is associated with Andersen cardiodysrhythmic periodic paralysis?",
    "seeds": [
      "Andersen cardiodysrhythmic periodic paralysis"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07208",
    "question": "What is associated with Adactyly?",
    "seeds": [
      "Adactyly"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07209",
    "question": "What phenotype is associated with Joubert syndrome with Jeune asphyxiating thoracic dystrophy?",
    "seeds": [
      "Joubert syndrome with Jeune asphyxiating thoracic dystrophy"
    ],
    "gold_answer": "Dysgenesis of the cerebellar vermis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07210",
    "question": "What is associated with Anterior mediastinal mass?",
    "seeds": [
      "Anterior mediastinal mass"
    ],
    "gold_answer": "Inferior mediastinal mass",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07211",
    "question": "What phenotype is associated with Neonatal alloimmune neutropenia?",
    "seeds": [
      "Neonatal alloimmune neutropenia"
    ],
    "gold_answer": "Maternal diabetes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07212",
    "question": "What phenotype is associated with Pulmonary fibrosis, idiopathic?",
    "seeds": [
      "Pulmonary fibrosis, idiopathic"
    ],
    "gold_answer": "Elevated bronchoalveolar lavage fluid neutrophil proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07213",
    "question": "What is associated with Interstitial dermal edema?",
    "seeds": [
      "Interstitial dermal edema"
    ],
    "gold_answer": "Abnormal dermis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07214",
    "question": "What is associated with Superficial blush-like subcutaneous fatty lesions?",
    "seeds": [
      "Superficial blush-like subcutaneous fatty lesions"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07215",
    "question": "What phenotype is associated with Deafness, autosomal recessive 6?",
    "seeds": [
      "Deafness, autosomal recessive 6"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07216",
    "question": "What is associated with Drug-sensitive hemolytic anemia?",
    "seeds": [
      "Drug-sensitive hemolytic anemia"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07217",
    "question": "What is associated with Pulmonary histoplasmosis?",
    "seeds": [
      "Pulmonary histoplasmosis"
    ],
    "gold_answer": "Histoplasmosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07218",
    "question": "What is associated with Abnormal Descemet membrane morphology?",
    "seeds": [
      "Abnormal Descemet membrane morphology"
    ],
    "gold_answer": "Abnormal corneal endothelium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07219",
    "question": "What is associated with High-frequency sensorineural hearing impairment?",
    "seeds": [
      "High-frequency sensorineural hearing impairment"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07220",
    "question": "What phenotype is associated with Homozygous familial hypercholesterolemia?",
    "seeds": [
      "Homozygous familial hypercholesterolemia"
    ],
    "gold_answer": "Hyperlipidemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07221",
    "question": "What phenotype is associated with Pulmonary alveolar proteinosis with hypogammaglobulinemia?",
    "seeds": [
      "Pulmonary alveolar proteinosis with hypogammaglobulinemia"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07222",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 18?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 18"
    ],
    "gold_answer": "Supraventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07223",
    "question": "What phenotype is associated with Pontocerebellar hypoplasia type 10?",
    "seeds": [
      "Pontocerebellar hypoplasia type 10"
    ],
    "gold_answer": "Abnormality of the cerebral cortex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07224",
    "question": "What is associated with Large basal ganglia?",
    "seeds": [
      "Large basal ganglia"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07225",
    "question": "What is associated with Rounded epiphyses?",
    "seeds": [
      "Rounded epiphyses"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07226",
    "question": "What is associated with Popliteal synovial cyst?",
    "seeds": [
      "Popliteal synovial cyst"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07227",
    "question": "What is associated with Severe SARS-CoV-2 infection?",
    "seeds": [
      "Severe SARS-CoV-2 infection"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07228",
    "question": "What phenotype is associated with Retinal dystrophy with or without extraocular anomalies?",
    "seeds": [
      "Retinal dystrophy with or without extraocular anomalies"
    ],
    "gold_answer": "Retinal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07229",
    "question": "What is associated with Renal arteriolar lumen cholesterol emboli?",
    "seeds": [
      "Renal arteriolar lumen cholesterol emboli"
    ],
    "gold_answer": "Abnormal renal arteriole lumen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07230",
    "question": "What is associated with Aplasia of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Aplasia of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal fifth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07231",
    "question": "What is associated with Anti-streptococcus deoxyribonuclease-B antibody positivity?",
    "seeds": [
      "Anti-streptococcus deoxyribonuclease-B antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07232",
    "question": "What phenotype is associated with Retinitis pigmentosa 90?",
    "seeds": [
      "Retinitis pigmentosa 90"
    ],
    "gold_answer": "Attenuation of retinal blood vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07233",
    "question": "What is associated with Obtuse angle of mandible?",
    "seeds": [
      "Obtuse angle of mandible"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07234",
    "question": "What phenotype is associated with Gaucher disease, type II?",
    "seeds": [
      "Gaucher disease, type II"
    ],
    "gold_answer": "Esophageal ulceration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07235",
    "question": "What is associated with Two-raphe bicuspid aortic valve?",
    "seeds": [
      "Two-raphe bicuspid aortic valve"
    ],
    "gold_answer": "Bicuspid aortic valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07236",
    "question": "What is associated with Solitary congenital hypertrophy of retinal pigment epithelium?",
    "seeds": [
      "Solitary congenital hypertrophy of retinal pigment epithelium"
    ],
    "gold_answer": "Abnormal fundus pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07237",
    "question": "What is associated with Pure red cell aplasia?",
    "seeds": [
      "Pure red cell aplasia"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07238",
    "question": "What is associated with Colorectal cancer, susceptibility to, 12?",
    "seeds": [
      "Colorectal cancer, susceptibility to, 12"
    ],
    "gold_answer": "Neoplasm of the rectum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07239",
    "question": "What is associated with Triggered by food ingestion?",
    "seeds": [
      "Triggered by food ingestion"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07240",
    "question": "What is associated with Abnormal pulmonary artery morphology?",
    "seeds": [
      "Abnormal pulmonary artery morphology"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07241",
    "question": "What is associated with Dysplasia of the femoral head?",
    "seeds": [
      "Dysplasia of the femoral head"
    ],
    "gold_answer": "Abnormal femoral head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07242",
    "question": "What is associated with Aphakia?",
    "seeds": [
      "Aphakia"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07243",
    "question": "What is associated with Poor appetite?",
    "seeds": [
      "Poor appetite"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07244",
    "question": "What is associated with Gingival cleft?",
    "seeds": [
      "Gingival cleft"
    ],
    "gold_answer": "Abnormality of the gingiva",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07245",
    "question": "What phenotype is associated with Dyskinesia with orofacial involvement, autosomal recessive?",
    "seeds": [
      "Dyskinesia with orofacial involvement, autosomal recessive"
    ],
    "gold_answer": "Dysarthria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07246",
    "question": "What is associated with Bullet-shaped 5th toe phalanx?",
    "seeds": [
      "Bullet-shaped 5th toe phalanx"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07247",
    "question": "What is associated with Vegan diet?",
    "seeds": [
      "Vegan diet"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07248",
    "question": "What phenotype is associated with Asparagine synthetase deficiency?",
    "seeds": [
      "Asparagine synthetase deficiency"
    ],
    "gold_answer": "Optic nerve aplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07249",
    "question": "What is associated with Abnormality of the epiphysis of the middle phalanx of the 4th toe?",
    "seeds": [
      "Abnormality of the epiphysis of the middle phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07250",
    "question": "What is associated with Adrenal medullary hypoplasia?",
    "seeds": [
      "Adrenal medullary hypoplasia"
    ],
    "gold_answer": "Adrenal hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07251",
    "question": "What is associated with Hyperpyrexia?",
    "seeds": [
      "Hyperpyrexia"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07252",
    "question": "What is associated with Bilateral parasagittal parieto-occipital polymicrogyria?",
    "seeds": [
      "Bilateral parasagittal parieto-occipital polymicrogyria"
    ],
    "gold_answer": "Disorder of thought content",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07253",
    "question": "What is associated with Garg-Mishra progeroid syndrome?",
    "seeds": [
      "Garg-Mishra progeroid syndrome"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07254",
    "question": "What phenotype is associated with Deafness, autosomal dominant 53?",
    "seeds": [
      "Deafness, autosomal dominant 53"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07255",
    "question": "What is associated with Pontocerebellar hypoplasia, type 8?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 8"
    ],
    "gold_answer": "Abnormal social behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07256",
    "question": "What is associated with Pelvic mass?",
    "seeds": [
      "Pelvic mass"
    ],
    "gold_answer": "Abnormal abdomen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07257",
    "question": "What is associated with Sparse axillary hair?",
    "seeds": [
      "Sparse axillary hair"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07258",
    "question": "What is associated with Carcinoid syndrome?",
    "seeds": [
      "Carcinoid syndrome"
    ],
    "gold_answer": "Abdominal pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07259",
    "question": "What phenotype is associated with Ankyloblepharon filiforme adnatum and cleft palate?",
    "seeds": [
      "Ankyloblepharon filiforme adnatum and cleft palate"
    ],
    "gold_answer": "Ankyloblepharon",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07260",
    "question": "What phenotype is associated with X-linked dominant chondrodysplasia punctata?",
    "seeds": [
      "X-linked dominant chondrodysplasia punctata"
    ],
    "gold_answer": "Paraparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07261",
    "question": "What is associated with Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 10?",
    "seeds": [
      "Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 10"
    ],
    "gold_answer": "Severe infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07262",
    "question": "What is associated with Torsion of the penis?",
    "seeds": [
      "Torsion of the penis"
    ],
    "gold_answer": "Abnormal penis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07263",
    "question": "What phenotype is associated with Citrulline transport defect?",
    "seeds": [
      "Citrulline transport defect"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07264",
    "question": "What is associated with ERG: Reduced dark-adapted b-wave amplitude?",
    "seeds": [
      "ERG: Reduced dark-adapted b-wave amplitude"
    ],
    "gold_answer": "Abnormal dark-adapted bright flash electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07265",
    "question": "What is associated with Charcot-Marie-Tooth disease type 1B?",
    "seeds": [
      "Charcot-Marie-Tooth disease type 1B"
    ],
    "gold_answer": "Peripheral axonal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07266",
    "question": "What is associated with Extension of hair growth on temples to lateral eyebrow?",
    "seeds": [
      "Extension of hair growth on temples to lateral eyebrow"
    ],
    "gold_answer": "Abnormality of the frontal hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07267",
    "question": "What is associated with Retinitis pigmentosa 96, autosomal dominant?",
    "seeds": [
      "Retinitis pigmentosa 96, autosomal dominant"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07268",
    "question": "What is associated with Hemolytic uremic syndrome, atypical, susceptibility to, 3?",
    "seeds": [
      "Hemolytic uremic syndrome, atypical, susceptibility to, 3"
    ],
    "gold_answer": "Decreased urine output",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07269",
    "question": "What is associated with Facial tics?",
    "seeds": [
      "Facial tics"
    ],
    "gold_answer": "Disturbance of facial expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07270",
    "question": "What is associated with Elevated cancer Ag 19-9 level?",
    "seeds": [
      "Elevated cancer Ag 19-9 level"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07271",
    "question": "What is associated with Medulloepithelioma?",
    "seeds": [
      "Medulloepithelioma"
    ],
    "gold_answer": "Central primitive neuroectodermal tumor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07272",
    "question": "What phenotype is associated with Osteopetrosis, autosomal recessive 2?",
    "seeds": [
      "Osteopetrosis, autosomal recessive 2"
    ],
    "gold_answer": "Hydrocephalus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07273",
    "question": "What is associated with 46,XY complete gonadal dysgenesis?",
    "seeds": [
      "46,XY complete gonadal dysgenesis"
    ],
    "gold_answer": "Ovarian cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07274",
    "question": "What is associated with Celiac disease, susceptibility to, 1?",
    "seeds": [
      "Celiac disease, susceptibility to, 1"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07275",
    "question": "What is associated with Abnormality of the epiphysis of the distal phalanx of the thumb?",
    "seeds": [
      "Abnormality of the epiphysis of the distal phalanx of the thumb"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07276",
    "question": "What is associated with Mitochondrial DNA depletion syndrome 4A (Alpers type)?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 4A (Alpers type)"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07277",
    "question": "What is associated with Retinal pigment epithelial mottling?",
    "seeds": [
      "Retinal pigment epithelial mottling"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07278",
    "question": "What is associated with Nephrotic syndrome, type 16?",
    "seeds": [
      "Nephrotic syndrome, type 16"
    ],
    "gold_answer": "Abnormal urine cytology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07279",
    "question": "What is associated with Akathisia?",
    "seeds": [
      "Akathisia"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07280",
    "question": "What is associated with Epidermolysis bullosa simplex 1B, generalized intermediate?",
    "seeds": [
      "Epidermolysis bullosa simplex 1B, generalized intermediate"
    ],
    "gold_answer": "Abnormality of the plantar skin of foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07281",
    "question": "What phenotype is associated with Combined immunodeficiency due to DOCK8 deficiency?",
    "seeds": [
      "Combined immunodeficiency due to DOCK8 deficiency"
    ],
    "gold_answer": "Recurrent sinusitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07282",
    "question": "What is associated with Spiculated?",
    "seeds": [
      "Spiculated"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07283",
    "question": "What is associated with Curry-Jones syndrome?",
    "seeds": [
      "Curry-Jones syndrome"
    ],
    "gold_answer": "Abnormality of globe size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07284",
    "question": "What is associated with White streaks/specks on enamel.?",
    "seeds": [
      "White streaks/specks on enamel."
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07285",
    "question": "What is associated with Glycogen storage disease 0, liver?",
    "seeds": [
      "Glycogen storage disease 0, liver"
    ],
    "gold_answer": "Abnormal blood glucose concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07286",
    "question": "What is associated with Familial Mediterranean fever?",
    "seeds": [
      "Familial Mediterranean fever"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07287",
    "question": "What is associated with Autoimmune interstitial lung, joint, and kidney disease?",
    "seeds": [
      "Autoimmune interstitial lung, joint, and kidney disease"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07288",
    "question": "What is associated with Chronic otitis media?",
    "seeds": [
      "Chronic otitis media"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07289",
    "question": "What is associated with Abnormal urinary electrolyte concentration?",
    "seeds": [
      "Abnormal urinary electrolyte concentration"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07290",
    "question": "What is associated with Increased circulating hemoglobin concentration?",
    "seeds": [
      "Increased circulating hemoglobin concentration"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07291",
    "question": "What is associated with Malignant hyperthermia, susceptibility to, 2?",
    "seeds": [
      "Malignant hyperthermia, susceptibility to, 2"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07292",
    "question": "What phenotype is associated with Muckle-Wells syndrome?",
    "seeds": [
      "Muckle-Wells syndrome"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07293",
    "question": "What is associated with Thoracolaryngopelvic dysplasia?",
    "seeds": [
      "Thoracolaryngopelvic dysplasia"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07294",
    "question": "What is associated with Hypermelanotic macule?",
    "seeds": [
      "Hypermelanotic macule"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07295",
    "question": "What is associated with Distal deletion 9p syndrome?",
    "seeds": [
      "Distal deletion 9p syndrome"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07296",
    "question": "What is associated with Aplasia/Hypoplasia involving the metacarpal bones?",
    "seeds": [
      "Aplasia/Hypoplasia involving the metacarpal bones"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07297",
    "question": "What is associated with 46,xy sex reversal 7?",
    "seeds": [
      "46,xy sex reversal 7"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the ovary",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07298",
    "question": "What phenotype is associated with Acrofacial dysostosis, Rodríguez type?",
    "seeds": [
      "Acrofacial dysostosis, Rodríguez type"
    ],
    "gold_answer": "Fibular hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07299",
    "question": "What is associated with Portal vein hypoplasia?",
    "seeds": [
      "Portal vein hypoplasia"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07300",
    "question": "What is associated with Increased vertical cup-to-disc ratio - 1.0?",
    "seeds": [
      "Increased vertical cup-to-disc ratio - 1.0"
    ],
    "gold_answer": "Abnormal optic disc morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07301",
    "question": "What phenotype is associated with Macrodactyly, somatic?",
    "seeds": [
      "Macrodactyly, somatic"
    ],
    "gold_answer": "Macrodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07302",
    "question": "What phenotype is associated with Bifid uvula?",
    "seeds": [
      "Bifid uvula"
    ],
    "gold_answer": "Submucous cleft soft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07303",
    "question": "What is associated with Potassium-wasting diuretic exposure?",
    "seeds": [
      "Potassium-wasting diuretic exposure"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07304",
    "question": "What is associated with Vulvar abscess?",
    "seeds": [
      "Vulvar abscess"
    ],
    "gold_answer": "Abnormal immune system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07305",
    "question": "What is associated with Emphysema?",
    "seeds": [
      "Emphysema"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07306",
    "question": "What is associated with Abnormality of the epiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Abnormality of the epiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal second toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07307",
    "question": "What is associated with Midline notch of upper alveolar ridge?",
    "seeds": [
      "Midline notch of upper alveolar ridge"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07308",
    "question": "What phenotype is associated with Oculoectodermal syndrome?",
    "seeds": [
      "Oculoectodermal syndrome"
    ],
    "gold_answer": "Synophrys",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07309",
    "question": "What is associated with Osteochondral lesion of talus?",
    "seeds": [
      "Osteochondral lesion of talus"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07310",
    "question": "What is associated with Abnormality of the proximal phalanx of the thumb?",
    "seeds": [
      "Abnormality of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Abnormality of thumb phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07311",
    "question": "What is associated with Osteolytic defects of the phalanges of the 4th finger?",
    "seeds": [
      "Osteolytic defects of the phalanges of the 4th finger"
    ],
    "gold_answer": "Osteolytic defects of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07312",
    "question": "What phenotype is associated with Tularemia?",
    "seeds": [
      "Tularemia"
    ],
    "gold_answer": "Meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07313",
    "question": "What is associated with Increased circulating mead acid level?",
    "seeds": [
      "Increased circulating mead acid level"
    ],
    "gold_answer": "Elevated circulating long chain fatty acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07314",
    "question": "What is associated with Abnormal circulating enzyme concentration?",
    "seeds": [
      "Abnormal circulating enzyme concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07315",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 10?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 10"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07316",
    "question": "What is associated with Sebaceous hyperplasia?",
    "seeds": [
      "Sebaceous hyperplasia"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07317",
    "question": "What is associated with Hypocitraturia?",
    "seeds": [
      "Hypocitraturia"
    ],
    "gold_answer": "Abnormal urine citrate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07318",
    "question": "What is associated with Hidrotic ectodermal dysplasia, Christianson-Fourie type?",
    "seeds": [
      "Hidrotic ectodermal dysplasia, Christianson-Fourie type"
    ],
    "gold_answer": "Absent hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07319",
    "question": "What is associated with Lumbar spondylosis?",
    "seeds": [
      "Lumbar spondylosis"
    ],
    "gold_answer": "Abnormal lumbar spine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07320",
    "question": "What is associated with Harel-Yoon syndrome?",
    "seeds": [
      "Harel-Yoon syndrome"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07321",
    "question": "What is associated with Immunodeficiency 124, severe combined?",
    "seeds": [
      "Immunodeficiency 124, severe combined"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07322",
    "question": "What is associated with Atrial septal defect-atrioventricular conduction defects syndrome?",
    "seeds": [
      "Atrial septal defect-atrioventricular conduction defects syndrome"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07323",
    "question": "What is associated with Pseudo-Von willebrand disease?",
    "seeds": [
      "Pseudo-Von willebrand disease"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07324",
    "question": "What is associated with Pontocerebellar hypoplasia, type 2C?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 2C"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07325",
    "question": "What is associated with Spherocytosis, type 2?",
    "seeds": [
      "Spherocytosis, type 2"
    ],
    "gold_answer": "Abnormal abdomen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07326",
    "question": "What is associated with Fractured sternoclavicular joint?",
    "seeds": [
      "Fractured sternoclavicular joint"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07327",
    "question": "What is associated with Abnormal circulating amylase concentration?",
    "seeds": [
      "Abnormal circulating amylase concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07328",
    "question": "What is associated with Reduced sterol 27-hydroxylase activity?",
    "seeds": [
      "Reduced sterol 27-hydroxylase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07329",
    "question": "What is associated with Abnormality of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Abnormality of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07330",
    "question": "What is associated with Cerebral amyloid angiopathy, APP-related?",
    "seeds": [
      "Cerebral amyloid angiopathy, APP-related"
    ],
    "gold_answer": "Abnormal cerebral artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07331",
    "question": "What is associated with Medially flattened radial epiphyses?",
    "seeds": [
      "Medially flattened radial epiphyses"
    ],
    "gold_answer": "Flattened radial epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07332",
    "question": "What is associated with Thyroid hormonogenesis, genetic defect in, 3?",
    "seeds": [
      "Thyroid hormonogenesis, genetic defect in, 3"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07333",
    "question": "What is associated with Increased monosialylated core 1 O-glycan level?",
    "seeds": [
      "Increased monosialylated core 1 O-glycan level"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07334",
    "question": "What is associated with Elevated CSF neopterin level?",
    "seeds": [
      "Elevated CSF neopterin level"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07335",
    "question": "What is associated with Early-onset severe Hermansky-Pudlak syndrome with hearing loss, due to AP3D1 deficiency?",
    "seeds": [
      "Early-onset severe Hermansky-Pudlak syndrome with hearing loss, due to AP3D1 deficiency"
    ],
    "gold_answer": "AP3D1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07336",
    "question": "What phenotype is associated with Jessner lymphocytic infiltration of the skin?",
    "seeds": [
      "Jessner lymphocytic infiltration of the skin"
    ],
    "gold_answer": "Cutaneous photosensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07337",
    "question": "What is associated with Global developmental delay, lung cysts, overgrowth, and wilms tumor?",
    "seeds": [
      "Global developmental delay, lung cysts, overgrowth, and wilms tumor"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the iris",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07338",
    "question": "What is associated with Shortening of all phalanges of fingers?",
    "seeds": [
      "Shortening of all phalanges of fingers"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07339",
    "question": "What is associated with Ullrich congenital muscular dystrophy?",
    "seeds": [
      "Ullrich congenital muscular dystrophy"
    ],
    "gold_answer": "COL6A3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07340",
    "question": "What is associated with Jaw pain?",
    "seeds": [
      "Jaw pain"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07341",
    "question": "What is associated with Long eyelashes?",
    "seeds": [
      "Long eyelashes"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07342",
    "question": "What is associated with Patchy sclerosis of 3rd toe phalanx?",
    "seeds": [
      "Patchy sclerosis of 3rd toe phalanx"
    ],
    "gold_answer": "Patchy sclerosis of toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07343",
    "question": "What is associated with Carpal displacement?",
    "seeds": [
      "Carpal displacement"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07344",
    "question": "What phenotype is associated with MEHMO syndrome?",
    "seeds": [
      "MEHMO syndrome"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07345",
    "question": "What is associated with Bone marrow granuloma?",
    "seeds": [
      "Bone marrow granuloma"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07346",
    "question": "What is associated with Ochronosis?",
    "seeds": [
      "Ochronosis"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07347",
    "question": "What is associated with Retinitis pigmentosa 33?",
    "seeds": [
      "Retinitis pigmentosa 33"
    ],
    "gold_answer": "Pigmentary retinopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07348",
    "question": "What is associated with Increased mannosylation of N-linked protein glycosylation?",
    "seeds": [
      "Increased mannosylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein N-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07349",
    "question": "What is associated with DEAFNESS, Y-LINKED 2?",
    "seeds": [
      "DEAFNESS, Y-LINKED 2"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07350",
    "question": "What is associated with Abnormal corneal epithelium morphology?",
    "seeds": [
      "Abnormal corneal epithelium morphology"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07351",
    "question": "What is associated with 5-minute APGAR score of 6?",
    "seeds": [
      "5-minute APGAR score of 6"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07352",
    "question": "What is associated with Sclerosis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Sclerosis of 2nd finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07353",
    "question": "What is associated with Posterior staphyloma?",
    "seeds": [
      "Posterior staphyloma"
    ],
    "gold_answer": "Scleral staphyloma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07354",
    "question": "What is associated with Palatal edema?",
    "seeds": [
      "Palatal edema"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07355",
    "question": "What is associated with Hemiballismus?",
    "seeds": [
      "Hemiballismus"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07356",
    "question": "What is associated with Restrictive external ophthalmoplegia?",
    "seeds": [
      "Restrictive external ophthalmoplegia"
    ],
    "gold_answer": "External ophthalmoplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07357",
    "question": "What is associated with Cutis laxa, autosomal recessive, type IIIB?",
    "seeds": [
      "Cutis laxa, autosomal recessive, type IIIB"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07358",
    "question": "What is associated with OSTEOMESOPYKNOSIS?",
    "seeds": [
      "OSTEOMESOPYKNOSIS"
    ],
    "gold_answer": "Back pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07359",
    "question": "What is associated with Abnormality of inferior crus of antihelix?",
    "seeds": [
      "Abnormality of inferior crus of antihelix"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07360",
    "question": "What is associated with Absent antitragus?",
    "seeds": [
      "Absent antitragus"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07361",
    "question": "What is associated with Impaired gluconeogenesis?",
    "seeds": [
      "Impaired gluconeogenesis"
    ],
    "gold_answer": "Abnormal glucose homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07362",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 10?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 10"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07363",
    "question": "What is associated with Renal tubular epithelial cell simplification?",
    "seeds": [
      "Renal tubular epithelial cell simplification"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07364",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanx of the 4th toe?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07365",
    "question": "What is associated with Hypoparathyroidism?",
    "seeds": [
      "Hypoparathyroidism"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07366",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 47?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 47"
    ],
    "gold_answer": "Mitral valve prolapse",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07367",
    "question": "What is associated with Multiple suture craniosynostosis?",
    "seeds": [
      "Multiple suture craniosynostosis"
    ],
    "gold_answer": "Abnormal cranial suture/fontanelle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07368",
    "question": "What is associated with New medication added in recent weeks?",
    "seeds": [
      "New medication added in recent weeks"
    ],
    "gold_answer": "Recent past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07369",
    "question": "What is associated with Temporal pattern?",
    "seeds": [
      "Temporal pattern"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07370",
    "question": "What is associated with Increased urinary glycerol?",
    "seeds": [
      "Increased urinary glycerol"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07371",
    "question": "What phenotype is associated with Hypertrophic cardiomyopathy with kidney anomalies due to mitochondrial DNA mutation?",
    "seeds": [
      "Hypertrophic cardiomyopathy with kidney anomalies due to mitochondrial DNA mutation"
    ],
    "gold_answer": "Increased CSF lactate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07372",
    "question": "What phenotype is associated with Osteogenesis imperfecta, type VII?",
    "seeds": [
      "Osteogenesis imperfecta, type VII"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07373",
    "question": "What is associated with Hernia, double inguinal?",
    "seeds": [
      "Hernia, double inguinal"
    ],
    "gold_answer": "Hernia of the abdominal wall",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07374",
    "question": "What is associated with Afibrinogenemia, congenitalhypofibrinogenemia, congenital, included?",
    "seeds": [
      "Afibrinogenemia, congenitalhypofibrinogenemia, congenital, included"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07375",
    "question": "What is associated with Spinocerebellar atrophy?",
    "seeds": [
      "Spinocerebellar atrophy"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07376",
    "question": "What phenotype is associated with Diamond-Blackfan anemia 22?",
    "seeds": [
      "Diamond-Blackfan anemia 22"
    ],
    "gold_answer": "Cellular hypersensitivity to mitomycin C",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07377",
    "question": "What is associated with Broad middle phalanx of the 5th finger?",
    "seeds": [
      "Broad middle phalanx of the 5th finger"
    ],
    "gold_answer": "Broad middle phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07378",
    "question": "What is associated with Idiopathic bronchiectasis?",
    "seeds": [
      "Idiopathic bronchiectasis"
    ],
    "gold_answer": "Weight loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07379",
    "question": "What is associated with Abnormal epidermis stratum granulosum morphology?",
    "seeds": [
      "Abnormal epidermis stratum granulosum morphology"
    ],
    "gold_answer": "Abnormal epidermal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07380",
    "question": "What phenotype is associated with Carey-Fineman-Ziter syndrome?",
    "seeds": [
      "Carey-Fineman-Ziter syndrome"
    ],
    "gold_answer": "Esophageal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07381",
    "question": "What is associated with Vasculitis in the skin?",
    "seeds": [
      "Vasculitis in the skin"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07382",
    "question": "What phenotype is associated with Immune defect due to absence of thymus?",
    "seeds": [
      "Immune defect due to absence of thymus"
    ],
    "gold_answer": "Reduced delayed hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07383",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 1?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 1"
    ],
    "gold_answer": "Abnormal tendon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07384",
    "question": "What is associated with Abnormal premolar morphology?",
    "seeds": [
      "Abnormal premolar morphology"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07385",
    "question": "What phenotype is associated with Retinitis pigmentosa 55?",
    "seeds": [
      "Retinitis pigmentosa 55"
    ],
    "gold_answer": "Rod-cone dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07386",
    "question": "What is associated with Osteolytic defects of the middle phalanx of the 2nd toe?",
    "seeds": [
      "Osteolytic defects of the middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal second toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07387",
    "question": "What is associated with Abnormal respiratory motile cilium morphology?",
    "seeds": [
      "Abnormal respiratory motile cilium morphology"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07388",
    "question": "What is associated with Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies?",
    "seeds": [
      "Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07389",
    "question": "What is associated with Methicillin-resistant Staphylococcus aureus infection?",
    "seeds": [
      "Methicillin-resistant Staphylococcus aureus infection"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07390",
    "question": "What phenotype is associated with VACTERL association, X-linked?",
    "seeds": [
      "VACTERL association, X-linked"
    ],
    "gold_answer": "Hydronephrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07391",
    "question": "What is associated with Reduced aromatase activity?",
    "seeds": [
      "Reduced aromatase activity"
    ],
    "gold_answer": "Abnormal aromatase activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07392",
    "question": "What is associated with Hypotrichosis 5?",
    "seeds": [
      "Hypotrichosis 5"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07393",
    "question": "What is associated with Displacement of the extensor tendon in metacarpophalangeal joint?",
    "seeds": [
      "Displacement of the extensor tendon in metacarpophalangeal joint"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07394",
    "question": "What is associated with Cardiorespiratory arrest?",
    "seeds": [
      "Cardiorespiratory arrest"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07395",
    "question": "What is associated with Aplasia/Hypoplasia of the 5th toe?",
    "seeds": [
      "Aplasia/Hypoplasia of the 5th toe"
    ],
    "gold_answer": "Absent toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07396",
    "question": "What is associated with Increased hemoglobin oxygen affinity?",
    "seeds": [
      "Increased hemoglobin oxygen affinity"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07397",
    "question": "What is associated with Male-limited expression?",
    "seeds": [
      "Male-limited expression"
    ],
    "gold_answer": "Sex-limited expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07398",
    "question": "What is associated with X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome?",
    "seeds": [
      "X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07399",
    "question": "What is associated with Calcification of cartilage?",
    "seeds": [
      "Calcification of cartilage"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07400",
    "question": "What is associated with Ectodermal dysplasia 7, Hair/nail type?",
    "seeds": [
      "Ectodermal dysplasia 7, Hair/nail type"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07401",
    "question": "What is associated with Abnormal CSF aromatic amino acid concentration?",
    "seeds": [
      "Abnormal CSF aromatic amino acid concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07402",
    "question": "What is associated with Spermatogenic failure, X-linked, 4?",
    "seeds": [
      "Spermatogenic failure, X-linked, 4"
    ],
    "gold_answer": "Decreased circulating androgen concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07403",
    "question": "What is associated with Congenital hypertrophy of retinal pigment epithelium?",
    "seeds": [
      "Congenital hypertrophy of retinal pigment epithelium"
    ],
    "gold_answer": "Fundus hyperpigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07404",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 34?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 34"
    ],
    "gold_answer": "Delayed CNS myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07405",
    "question": "What is associated with Immunodeficiency, common variable, 11?",
    "seeds": [
      "Immunodeficiency, common variable, 11"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07406",
    "question": "What is associated with Spastic paraplegia 51, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 51, autosomal recessive"
    ],
    "gold_answer": "Cerebral palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07407",
    "question": "What is associated with Abnormal circulating proteinogenic amino acid concentration?",
    "seeds": [
      "Abnormal circulating proteinogenic amino acid concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07408",
    "question": "What is associated with Bifid proximal phalanx of the thumb?",
    "seeds": [
      "Bifid proximal phalanx of the thumb"
    ],
    "gold_answer": "Duplication of the middle phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07409",
    "question": "What is associated with Elevated circulating membrane cofactor protein concentration?",
    "seeds": [
      "Elevated circulating membrane cofactor protein concentration"
    ],
    "gold_answer": "Abnormal circulating membrane cofactor protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07410",
    "question": "What is associated with Neoplasm of the adrenal gland?",
    "seeds": [
      "Neoplasm of the adrenal gland"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07411",
    "question": "What is associated with Increased cerebral lipofuscin?",
    "seeds": [
      "Increased cerebral lipofuscin"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07412",
    "question": "What is associated with Sudden cardiac failure, infantile?",
    "seeds": [
      "Sudden cardiac failure, infantile"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07413",
    "question": "What is associated with Cervical (neck)?",
    "seeds": [
      "Cervical (neck)"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07414",
    "question": "What phenotype is associated with Adult intestinal botulism?",
    "seeds": [
      "Adult intestinal botulism"
    ],
    "gold_answer": "Respiratory insufficiency due to muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07415",
    "question": "What is associated with Abnormal sella turcica morphology?",
    "seeds": [
      "Abnormal sella turcica morphology"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07416",
    "question": "What is associated with Renpenning syndrome?",
    "seeds": [
      "Renpenning syndrome"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07417",
    "question": "What is associated with Cortical subperiosteal resorption of humeral metaphyses?",
    "seeds": [
      "Cortical subperiosteal resorption of humeral metaphyses"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07418",
    "question": "What is associated with Sclerosis of metaphyses of the upper limbs?",
    "seeds": [
      "Sclerosis of metaphyses of the upper limbs"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07419",
    "question": "What is associated with Cortical radial artery leukocyte hypercellularity?",
    "seeds": [
      "Cortical radial artery leukocyte hypercellularity"
    ],
    "gold_answer": "Abnormal cortical radial artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07420",
    "question": "What is associated with Multicentric ossification of proximal femoral epiphyses?",
    "seeds": [
      "Multicentric ossification of proximal femoral epiphyses"
    ],
    "gold_answer": "Abnormal femoral head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07421",
    "question": "What is associated with Spastic paraplegia 72B, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 72B, autosomal recessive"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07422",
    "question": "What is associated with Positive stool giardia antigen?",
    "seeds": [
      "Positive stool giardia antigen"
    ],
    "gold_answer": "Abnormal stool composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07423",
    "question": "What is associated with Anterior segment dysgenesis 3?",
    "seeds": [
      "Anterior segment dysgenesis 3"
    ],
    "gold_answer": "Abnormal pupil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07424",
    "question": "What is associated with Neurodevelopmental disorder with dystonia and seizures?",
    "seeds": [
      "Neurodevelopmental disorder with dystonia and seizures"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07425",
    "question": "What is associated with Ceroid lipofuscinosis, neuronal, 6?",
    "seeds": [
      "Ceroid lipofuscinosis, neuronal, 6"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07426",
    "question": "What is associated with Immune dysregulation?",
    "seeds": [
      "Immune dysregulation"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07427",
    "question": "What is associated with Lateral rectus muscle weakness?",
    "seeds": [
      "Lateral rectus muscle weakness"
    ],
    "gold_answer": "Abnormal lateral rectus muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07428",
    "question": "What is associated with Split-Hand/foot malformation 2?",
    "seeds": [
      "Split-Hand/foot malformation 2"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07429",
    "question": "What is associated with Abnormal chylomicron concentration?",
    "seeds": [
      "Abnormal chylomicron concentration"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07430",
    "question": "What is associated with Contracture of the metatarsophalangeal joint of the 5th toe?",
    "seeds": [
      "Contracture of the metatarsophalangeal joint of the 5th toe"
    ],
    "gold_answer": "Flexion contracture of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07431",
    "question": "What is associated with Blotching pigmentation of the skin?",
    "seeds": [
      "Blotching pigmentation of the skin"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07432",
    "question": "What is associated with Lateral rectus muscle weakness?",
    "seeds": [
      "Lateral rectus muscle weakness"
    ],
    "gold_answer": "Abnormal horizontal rectus muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07433",
    "question": "What is associated with Secondary hypercortisolism?",
    "seeds": [
      "Secondary hypercortisolism"
    ],
    "gold_answer": "Abnormality of adrenal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07434",
    "question": "What is associated with Retinal peau d'orange?",
    "seeds": [
      "Retinal peau d'orange"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07435",
    "question": "What is associated with Elevated circulating phosphoethanolamine concentration?",
    "seeds": [
      "Elevated circulating phosphoethanolamine concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07436",
    "question": "What is associated with Cone-shaped epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Cone-shaped epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Cone-shaped epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07437",
    "question": "What is associated with Inguinal freckling?",
    "seeds": [
      "Inguinal freckling"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07438",
    "question": "What is associated with Vagal paraganglioma?",
    "seeds": [
      "Vagal paraganglioma"
    ],
    "gold_answer": "Paraganglioma of head and neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07439",
    "question": "What is associated with Spastic paraparesis-deafness syndrome?",
    "seeds": [
      "Spastic paraparesis-deafness syndrome"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07440",
    "question": "What is associated with Focal aware emotional seizure with anger?",
    "seeds": [
      "Focal aware emotional seizure with anger"
    ],
    "gold_answer": "Focal emotional seizure with anger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07441",
    "question": "What is associated with Neurodevelopmental disorder with microcephaly, absent speech, and hypotonia?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, absent speech, and hypotonia"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07442",
    "question": "What is associated with Irregular tarsal ossification?",
    "seeds": [
      "Irregular tarsal ossification"
    ],
    "gold_answer": "Abnormal tarsal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07443",
    "question": "What is associated with Salivary basal cell adenoma?",
    "seeds": [
      "Salivary basal cell adenoma"
    ],
    "gold_answer": "Neoplasm of the oral cavity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07444",
    "question": "What is associated with Abnormal proximal phalanx morphology of the hand?",
    "seeds": [
      "Abnormal proximal phalanx morphology of the hand"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07445",
    "question": "What is associated with Thiamine-responsive maple syrup urine disease?",
    "seeds": [
      "Thiamine-responsive maple syrup urine disease"
    ],
    "gold_answer": "DBT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_07446",
    "question": "What is associated with Lupus nephritis?",
    "seeds": [
      "Lupus nephritis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07447",
    "question": "What is associated with Abnormal gastrointestinal transit time?",
    "seeds": [
      "Abnormal gastrointestinal transit time"
    ],
    "gold_answer": "Abnormal gastrointestinal motility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07448",
    "question": "What is associated with Abnormal reproductive system morphology?",
    "seeds": [
      "Abnormal reproductive system morphology"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07449",
    "question": "What phenotype is associated with Autoinflammatory syndrome, familial, with or without immunodeficiency?",
    "seeds": [
      "Autoinflammatory syndrome, familial, with or without immunodeficiency"
    ],
    "gold_answer": "Lymphadenopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07450",
    "question": "What is associated with Chronic lymphatic leukemia?",
    "seeds": [
      "Chronic lymphatic leukemia"
    ],
    "gold_answer": "Hematological neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07451",
    "question": "What is associated with Meier-Gorlin syndrome 1?",
    "seeds": [
      "Meier-Gorlin syndrome 1"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07452",
    "question": "What is associated with Anticardiolipin IgG antibody positivity?",
    "seeds": [
      "Anticardiolipin IgG antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07453",
    "question": "What is associated with Abnormal pulmonary fissure count?",
    "seeds": [
      "Abnormal pulmonary fissure count"
    ],
    "gold_answer": "Abnormal pulmonary fissure morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07454",
    "question": "What is associated with Diamond-Blackfan anemia 4?",
    "seeds": [
      "Diamond-Blackfan anemia 4"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07455",
    "question": "What is associated with Enlarged epiphyses of the 4th finger?",
    "seeds": [
      "Enlarged epiphyses of the 4th finger"
    ],
    "gold_answer": "Enlarged epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07456",
    "question": "What phenotype is associated with Inflammatory bowel disease 28, early onset, autosomal recessive?",
    "seeds": [
      "Inflammatory bowel disease 28, early onset, autosomal recessive"
    ],
    "gold_answer": "Crohn's disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07457",
    "question": "What is associated with Deafness, autosomal recessive 91?",
    "seeds": [
      "Deafness, autosomal recessive 91"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07458",
    "question": "What is associated with Cranial asymmetry?",
    "seeds": [
      "Cranial asymmetry"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07459",
    "question": "What is associated with Ehlers-danlos syndrome, Hypermobility type?",
    "seeds": [
      "Ehlers-danlos syndrome, Hypermobility type"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07460",
    "question": "What is associated with Confusion?",
    "seeds": [
      "Confusion"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07461",
    "question": "What is associated with Specific anosmia?",
    "seeds": [
      "Specific anosmia"
    ],
    "gold_answer": "Abnormality of the sense of smell",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07462",
    "question": "What is associated with Abnormality of the epiphysis of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Abnormality of the epiphysis of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal third toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07463",
    "question": "What is associated with Complex palmar dermatoglyphic pattern?",
    "seeds": [
      "Complex palmar dermatoglyphic pattern"
    ],
    "gold_answer": "Abnormal palmar dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07464",
    "question": "What is associated with Chest pain triggered by palpation?",
    "seeds": [
      "Chest pain triggered by palpation"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07465",
    "question": "What phenotype is associated with Centrifugal lipodystrophy?",
    "seeds": [
      "Centrifugal lipodystrophy"
    ],
    "gold_answer": "Erythema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07466",
    "question": "What phenotype is associated with Idiopathic panuveitis?",
    "seeds": [
      "Idiopathic panuveitis"
    ],
    "gold_answer": "Vitreous haze",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07467",
    "question": "What phenotype is associated with Facial clefting, oblique, 1?",
    "seeds": [
      "Facial clefting, oblique, 1"
    ],
    "gold_answer": "Talipes calcaneovalgus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07468",
    "question": "What is associated with Abnormal pulmonary vein physiology?",
    "seeds": [
      "Abnormal pulmonary vein physiology"
    ],
    "gold_answer": "Abnormality of the pulmonary veins",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07469",
    "question": "What is associated with Abnormal femoral epiphysis morphology?",
    "seeds": [
      "Abnormal femoral epiphysis morphology"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07470",
    "question": "What is associated with Bardet-Biedl syndrome 14?",
    "seeds": [
      "Bardet-Biedl syndrome 14"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07471",
    "question": "What is associated with FLNA-related X-linked myxomatous valvular dysplasia?",
    "seeds": [
      "FLNA-related X-linked myxomatous valvular dysplasia"
    ],
    "gold_answer": "FLNA",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07472",
    "question": "What is associated with Anti-recoverin antibody positivity?",
    "seeds": [
      "Anti-recoverin antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07473",
    "question": "What is associated with Partial absence of foot?",
    "seeds": [
      "Partial absence of foot"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07474",
    "question": "What is associated with Saccadic smooth pursuit interruptions?",
    "seeds": [
      "Saccadic smooth pursuit interruptions"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07475",
    "question": "What phenotype is associated with Immunodeficiency 84?",
    "seeds": [
      "Immunodeficiency 84"
    ],
    "gold_answer": "Decreased total B cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07476",
    "question": "What is associated with Hypophoria?",
    "seeds": [
      "Hypophoria"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07477",
    "question": "What is associated with Vestibulopathy, familial?",
    "seeds": [
      "Vestibulopathy, familial"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07478",
    "question": "What is associated with Out-toeing?",
    "seeds": [
      "Out-toeing"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07479",
    "question": "What is associated with Delayed ability to roll over?",
    "seeds": [
      "Delayed ability to roll over"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07480",
    "question": "What phenotype is associated with Dental radicular dysplasia?",
    "seeds": [
      "Dental radicular dysplasia"
    ],
    "gold_answer": "Hypoplasia of the dental root",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07481",
    "question": "What is associated with Premature ovarian failure 15?",
    "seeds": [
      "Premature ovarian failure 15"
    ],
    "gold_answer": "Amenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07482",
    "question": "What is associated with Cerebral cortical atrophy?",
    "seeds": [
      "Cerebral cortical atrophy"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07483",
    "question": "What is associated with Oliver syndrome?",
    "seeds": [
      "Oliver syndrome"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07484",
    "question": "What is associated with Increased circulating free T3?",
    "seeds": [
      "Increased circulating free T3"
    ],
    "gold_answer": "Abnormal circulating free T3 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07485",
    "question": "What is associated with Auriculocondylar syndrome 3?",
    "seeds": [
      "Auriculocondylar syndrome 3"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07486",
    "question": "What phenotype is associated with Deafness, sensorineural, with pituitary dwarfism?",
    "seeds": [
      "Deafness, sensorineural, with pituitary dwarfism"
    ],
    "gold_answer": "Gonadotropin deficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07487",
    "question": "What is associated with Congenital myopathy 26?",
    "seeds": [
      "Congenital myopathy 26"
    ],
    "gold_answer": "Lower limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07488",
    "question": "What is associated with Immunodeficiency 42?",
    "seeds": [
      "Immunodeficiency 42"
    ],
    "gold_answer": "Stomatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07489",
    "question": "What is associated with Pseudoaminopterin syndrome?",
    "seeds": [
      "Pseudoaminopterin syndrome"
    ],
    "gold_answer": "Conductive hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07490",
    "question": "What is associated with Hereditary sensory and autonomic neuropathy type 6?",
    "seeds": [
      "Hereditary sensory and autonomic neuropathy type 6"
    ],
    "gold_answer": "DST",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07491",
    "question": "What is associated with Autosomal dominant brachyolmia?",
    "seeds": [
      "Autosomal dominant brachyolmia"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07492",
    "question": "What is associated with Gallbladder biliary sludging?",
    "seeds": [
      "Gallbladder biliary sludging"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07493",
    "question": "What is associated with Reduced circulating aldolase concentration?",
    "seeds": [
      "Reduced circulating aldolase concentration"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07494",
    "question": "What is associated with Iris hyperemia?",
    "seeds": [
      "Iris hyperemia"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07495",
    "question": "What is associated with Myelodysplasia and leukemia syndrome with monosomy 7?",
    "seeds": [
      "Myelodysplasia and leukemia syndrome with monosomy 7"
    ],
    "gold_answer": "Abnormal mean corpuscular volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07496",
    "question": "What is associated with Wiedemann-Rautenstrauch syndrome?",
    "seeds": [
      "Wiedemann-Rautenstrauch syndrome"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07497",
    "question": "What is associated with Recurrent herpes?",
    "seeds": [
      "Recurrent herpes"
    ],
    "gold_answer": "Unusual viral infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07498",
    "question": "What is associated with Deafness, autosomal recessive 16?",
    "seeds": [
      "Deafness, autosomal recessive 16"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07499",
    "question": "What is associated with Hypertonia?",
    "seeds": [
      "Hypertonia"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07500",
    "question": "What is associated with Thick anterior alveolar ridges?",
    "seeds": [
      "Thick anterior alveolar ridges"
    ],
    "gold_answer": "Abnormal alveolar ridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07501",
    "question": "What is associated with Radiation sensitivity of natural killer activity?",
    "seeds": [
      "Radiation sensitivity of natural killer activity"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07502",
    "question": "What is associated with Nasal bones, absence of?",
    "seeds": [
      "Nasal bones, absence of"
    ],
    "gold_answer": "Abnormal columella morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07503",
    "question": "What is associated with ALG8-CDG?",
    "seeds": [
      "ALG8-CDG"
    ],
    "gold_answer": "Abnormal placental size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07504",
    "question": "What is associated with Lack of pupillary response to hydroxyamphetamine?",
    "seeds": [
      "Lack of pupillary response to hydroxyamphetamine"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07505",
    "question": "What is associated with Vascular granular osmiophilic material deposition?",
    "seeds": [
      "Vascular granular osmiophilic material deposition"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07506",
    "question": "What is associated with Unossified vertebral bodies?",
    "seeds": [
      "Unossified vertebral bodies"
    ],
    "gold_answer": "Abnormal enchondral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07507",
    "question": "What is associated with Aplasia/Hypoplasia of the calvaria?",
    "seeds": [
      "Aplasia/Hypoplasia of the calvaria"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07508",
    "question": "What is associated with Short sleep, familial natural, 2?",
    "seeds": [
      "Short sleep, familial natural, 2"
    ],
    "gold_answer": "Sleep-wake cycle disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07509",
    "question": "What is associated with Nance-Horan syndrome?",
    "seeds": [
      "Nance-Horan syndrome"
    ],
    "gold_answer": "Tooth malposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07510",
    "question": "What is associated with Anti-muscle-specific tyrosine kinase antibody?",
    "seeds": [
      "Anti-muscle-specific tyrosine kinase antibody"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07511",
    "question": "What is associated with Aminoaciduria?",
    "seeds": [
      "Aminoaciduria"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07512",
    "question": "What is associated with Anomalous origin of right pulmonary artery from ascending aorta?",
    "seeds": [
      "Anomalous origin of right pulmonary artery from ascending aorta"
    ],
    "gold_answer": "Abnormal pulmonary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07513",
    "question": "What is associated with Nuclear cataract?",
    "seeds": [
      "Nuclear cataract"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07514",
    "question": "What is associated with Bronchial telangiectasia?",
    "seeds": [
      "Bronchial telangiectasia"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07515",
    "question": "What is associated with Speech articulation difficulties?",
    "seeds": [
      "Speech articulation difficulties"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07516",
    "question": "What is associated with Wrist ganglion?",
    "seeds": [
      "Wrist ganglion"
    ],
    "gold_answer": "Abnormality of the wrist",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07517",
    "question": "What is associated with Posterior Y-sutural cataract?",
    "seeds": [
      "Posterior Y-sutural cataract"
    ],
    "gold_answer": "Sutural cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07518",
    "question": "What is associated with AIDS wasting syndrome?",
    "seeds": [
      "AIDS wasting syndrome"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07519",
    "question": "What is associated with Achalasia, familial esophageal?",
    "seeds": [
      "Achalasia, familial esophageal"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07520",
    "question": "What is associated with Highly elevated creatine kinase?",
    "seeds": [
      "Highly elevated creatine kinase"
    ],
    "gold_answer": "Elevated circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07521",
    "question": "What is associated with Jaw claudication?",
    "seeds": [
      "Jaw claudication"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07522",
    "question": "What is associated with Deafness, autosomal recessive 116?",
    "seeds": [
      "Deafness, autosomal recessive 116"
    ],
    "gold_answer": "Somatic sensory dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07523",
    "question": "What phenotype is associated with Kaya-Barakat-Masson syndrome?",
    "seeds": [
      "Kaya-Barakat-Masson syndrome"
    ],
    "gold_answer": "Spastic tetraplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07524",
    "question": "What is associated with Dysgyria with normal cortical thickness?",
    "seeds": [
      "Dysgyria with normal cortical thickness"
    ],
    "gold_answer": "Abnormal cortical gyration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07525",
    "question": "What is associated with Pleural cyst?",
    "seeds": [
      "Pleural cyst"
    ],
    "gold_answer": "Abnormal pleura morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07526",
    "question": "What is associated with Ehlers-Danlos syndrome, arthrochalasia type, 1?",
    "seeds": [
      "Ehlers-Danlos syndrome, arthrochalasia type, 1"
    ],
    "gold_answer": "Knee dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07527",
    "question": "What is associated with Limited Repertoire of gestures?",
    "seeds": [
      "Limited Repertoire of gestures"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07528",
    "question": "What is associated with Male hypogonadism?",
    "seeds": [
      "Male hypogonadism"
    ],
    "gold_answer": "Functional abnormality of male internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07529",
    "question": "What is associated with Unilateral lung agenesis?",
    "seeds": [
      "Unilateral lung agenesis"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07530",
    "question": "What phenotype is associated with Hypogonadotropic hypogonadism 10 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 10 with or without anosmia"
    ],
    "gold_answer": "Primary amenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07531",
    "question": "What is associated with Class I obesity?",
    "seeds": [
      "Class I obesity"
    ],
    "gold_answer": "Increased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07532",
    "question": "What is associated with Localized along nerve distribution?",
    "seeds": [
      "Localized along nerve distribution"
    ],
    "gold_answer": "Localized",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07533",
    "question": "What phenotype is associated with Spondyloocular syndrome?",
    "seeds": [
      "Spondyloocular syndrome"
    ],
    "gold_answer": "Abnormal sclera morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07534",
    "question": "What phenotype is associated with Ascites, chylous?",
    "seeds": [
      "Ascites, chylous"
    ],
    "gold_answer": "Pancreatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07535",
    "question": "What is associated with Acetabular erosions?",
    "seeds": [
      "Acetabular erosions"
    ],
    "gold_answer": "Abnormal hip joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07536",
    "question": "What is associated with Motor axonal neuropathy?",
    "seeds": [
      "Motor axonal neuropathy"
    ],
    "gold_answer": "Abnormal peripheral nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07537",
    "question": "What phenotype is associated with Thrombotic thrombocytopenic purpura?",
    "seeds": [
      "Thrombotic thrombocytopenic purpura"
    ],
    "gold_answer": "Acute kidney injury",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07538",
    "question": "What is associated with Isolated asymptomatic elevation of creatine phosphokinase?",
    "seeds": [
      "Isolated asymptomatic elevation of creatine phosphokinase"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07539",
    "question": "What is associated with Aplasia/Hypoplasia of the 3rd metacarpal?",
    "seeds": [
      "Aplasia/Hypoplasia of the 3rd metacarpal"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07540",
    "question": "What is associated with Neuronal loss in the cerebral cortex?",
    "seeds": [
      "Neuronal loss in the cerebral cortex"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07541",
    "question": "What is associated with Multifocal epileptiform discharges?",
    "seeds": [
      "Multifocal epileptiform discharges"
    ],
    "gold_answer": "EEG with focal epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07542",
    "question": "What is associated with Optic nerve misrouting?",
    "seeds": [
      "Optic nerve misrouting"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07543",
    "question": "What is associated with Chronic hepatic encephalopathy?",
    "seeds": [
      "Chronic hepatic encephalopathy"
    ],
    "gold_answer": "Encephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07544",
    "question": "What is associated with Growth hormone deficiency, isolated partial?",
    "seeds": [
      "Growth hormone deficiency, isolated partial"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07545",
    "question": "What phenotype is associated with Epidermolytic hyperkeratosis 2B, autosomal recessive?",
    "seeds": [
      "Epidermolytic hyperkeratosis 2B, autosomal recessive"
    ],
    "gold_answer": "Keratinocyte vacuolization",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07546",
    "question": "What is associated with Lymph node abscess?",
    "seeds": [
      "Lymph node abscess"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07547",
    "question": "What is associated with Abnormal CSF lysine concentration?",
    "seeds": [
      "Abnormal CSF lysine concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07548",
    "question": "What is associated with Postaxial tetramelic oligodactyly?",
    "seeds": [
      "Postaxial tetramelic oligodactyly"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07549",
    "question": "What is associated with Abnormal cry?",
    "seeds": [
      "Abnormal cry"
    ],
    "gold_answer": "Abnormality of the voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07550",
    "question": "What is associated with Short eyelashes?",
    "seeds": [
      "Short eyelashes"
    ],
    "gold_answer": "Abnormal eyelash morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07551",
    "question": "What is associated with Decreased galactosylation of N-linked protein glycosylation?",
    "seeds": [
      "Decreased galactosylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein N-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07552",
    "question": "What is associated with Renal atrophy?",
    "seeds": [
      "Renal atrophy"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07553",
    "question": "What is associated with Abnormality of vitamin K metabolism?",
    "seeds": [
      "Abnormality of vitamin K metabolism"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07554",
    "question": "What is associated with Genetic transient congenital hypothyroidism?",
    "seeds": [
      "Genetic transient congenital hypothyroidism"
    ],
    "gold_answer": "Abnormality of muscle size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07555",
    "question": "What is associated with Robinow syndrome, autosomal dominant 2?",
    "seeds": [
      "Robinow syndrome, autosomal dominant 2"
    ],
    "gold_answer": "Craniofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07556",
    "question": "What phenotype is associated with Pancreatic agenesis-holoprosencephaly syndrome?",
    "seeds": [
      "Pancreatic agenesis-holoprosencephaly syndrome"
    ],
    "gold_answer": "Gastroesophageal reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07557",
    "question": "What is associated with Sclerosis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Sclerosis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07558",
    "question": "What is associated with Prominent superficial veins?",
    "seeds": [
      "Prominent superficial veins"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07559",
    "question": "What is associated with Osteolytic defects of the phalanges of the 3rd toe?",
    "seeds": [
      "Osteolytic defects of the phalanges of the 3rd toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07560",
    "question": "What is associated with Latex allergy?",
    "seeds": [
      "Latex allergy"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07561",
    "question": "What is associated with Posterior blepharitis?",
    "seeds": [
      "Posterior blepharitis"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07562",
    "question": "What phenotype is associated with Temporal arteritis?",
    "seeds": [
      "Temporal arteritis"
    ],
    "gold_answer": "Elevated erythrocyte sedimentation rate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07563",
    "question": "What is associated with Prolonged prothrombin time?",
    "seeds": [
      "Prolonged prothrombin time"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07564",
    "question": "What is associated with Abnormal epididymis morphology?",
    "seeds": [
      "Abnormal epididymis morphology"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07565",
    "question": "What is associated with Renal interstitial eosinophil infiltration?",
    "seeds": [
      "Renal interstitial eosinophil infiltration"
    ],
    "gold_answer": "Abnormal renal interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07566",
    "question": "What is associated with Immunodeficiency, X-linked, with deficiency of 115,000 dalton surfaceglycoprotein?",
    "seeds": [
      "Immunodeficiency, X-linked, with deficiency of 115,000 dalton surfaceglycoprotein"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07567",
    "question": "What is associated with Deafness, autosomal recessive 59?",
    "seeds": [
      "Deafness, autosomal recessive 59"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07568",
    "question": "What is associated with Nonspherocytic hemolytic anemia?",
    "seeds": [
      "Nonspherocytic hemolytic anemia"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07569",
    "question": "What is associated with Reduced T cell CD40 expression?",
    "seeds": [
      "Reduced T cell CD40 expression"
    ],
    "gold_answer": "Abnormal lymphocyte surface marker expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07570",
    "question": "What is associated with Decreased circulating complement factor H concentration?",
    "seeds": [
      "Decreased circulating complement factor H concentration"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07571",
    "question": "What is associated with Decreased lymph node lymphocyte cytoplasm?",
    "seeds": [
      "Decreased lymph node lymphocyte cytoplasm"
    ],
    "gold_answer": "Abnormal lymph-node cellular finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07572",
    "question": "What is associated with Coiled sperm flagella?",
    "seeds": [
      "Coiled sperm flagella"
    ],
    "gold_answer": "Abnormal male germ cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07573",
    "question": "What phenotype is associated with Cornelia de Lange syndrome 1?",
    "seeds": [
      "Cornelia de Lange syndrome 1"
    ],
    "gold_answer": "Abnormal incisura morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07574",
    "question": "What is associated with Hooded upper eyelid?",
    "seeds": [
      "Hooded upper eyelid"
    ],
    "gold_answer": "Hooded eyelid",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07575",
    "question": "What is associated with Widened distal phalanges?",
    "seeds": [
      "Widened distal phalanges"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07576",
    "question": "What is associated with IgG4-related submandibular gland disease?",
    "seeds": [
      "IgG4-related submandibular gland disease"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07577",
    "question": "What is associated with Positive cutaneous herpes simplex virus nucleic acid test?",
    "seeds": [
      "Positive cutaneous herpes simplex virus nucleic acid test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07578",
    "question": "What is associated with Lumbar interpedicular narrowing?",
    "seeds": [
      "Lumbar interpedicular narrowing"
    ],
    "gold_answer": "Vertebral arch anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07579",
    "question": "What is associated with Dermal atrophy?",
    "seeds": [
      "Dermal atrophy"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07580",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 30?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 30"
    ],
    "gold_answer": "Ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07581",
    "question": "What is associated with Whistling appearance?",
    "seeds": [
      "Whistling appearance"
    ],
    "gold_answer": "Abnormality of mouth shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07582",
    "question": "What is associated with Abnormal mitochondrial number?",
    "seeds": [
      "Abnormal mitochondrial number"
    ],
    "gold_answer": "Abnormality of the mitochondrion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07583",
    "question": "What is associated with Modic type vertebral endplate changes?",
    "seeds": [
      "Modic type vertebral endplate changes"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07584",
    "question": "What is associated with NK-cell enteropathy?",
    "seeds": [
      "NK-cell enteropathy"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07585",
    "question": "What is associated with Fountain syndrome?",
    "seeds": [
      "Fountain syndrome"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07586",
    "question": "What is associated with Flattened metacarpal heads?",
    "seeds": [
      "Flattened metacarpal heads"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07587",
    "question": "What is associated with Chronic gastritis?",
    "seeds": [
      "Chronic gastritis"
    ],
    "gold_answer": "Abnormal stomach morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07588",
    "question": "What is associated with Wiedemann-Rautenstrauch syndrome?",
    "seeds": [
      "Wiedemann-Rautenstrauch syndrome"
    ],
    "gold_answer": "Abnormality of dental eruption",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07589",
    "question": "What phenotype is associated with Diffuse palmoplantar keratoderma-acrocyanosis syndrome?",
    "seeds": [
      "Diffuse palmoplantar keratoderma-acrocyanosis syndrome"
    ],
    "gold_answer": "Acrocyanosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07590",
    "question": "What is associated with Alcohol-induced rhabdomyolysis?",
    "seeds": [
      "Alcohol-induced rhabdomyolysis"
    ],
    "gold_answer": "Rhabdomyolysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07591",
    "question": "What is associated with Neonatal epileptic encephalopathy due to glutaminase deficiency?",
    "seeds": [
      "Neonatal epileptic encephalopathy due to glutaminase deficiency"
    ],
    "gold_answer": "GLS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_07592",
    "question": "What is associated with B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome?",
    "seeds": [
      "B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07593",
    "question": "What is associated with Reduced alpha-methylacyl-CoA racemase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced alpha-methylacyl-CoA racemase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07594",
    "question": "What is associated with Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome?",
    "seeds": [
      "Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome"
    ],
    "gold_answer": "Abnormal circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07595",
    "question": "What is associated with Abnormality of hair pigmentation?",
    "seeds": [
      "Abnormality of hair pigmentation"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07596",
    "question": "What is associated with Incisors, rotation of upper central?",
    "seeds": [
      "Incisors, rotation of upper central"
    ],
    "gold_answer": "Abnormality of the incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07597",
    "question": "What is associated with Pear-shaped vertebrae?",
    "seeds": [
      "Pear-shaped vertebrae"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07598",
    "question": "What is associated with Anti-FGFR3 antibody positivity?",
    "seeds": [
      "Anti-FGFR3 antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07599",
    "question": "What is associated with Thoracic cage flatness?",
    "seeds": [
      "Thoracic cage flatness"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07600",
    "question": "What is associated with Extrahepatic bile duct fibrosis?",
    "seeds": [
      "Extrahepatic bile duct fibrosis"
    ],
    "gold_answer": "Abnormal extrahepatic bile duct morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07601",
    "question": "What phenotype is associated with Intellectual developmental disorder with dysmorphic facies, speech delay, and T-cell abnormalities?",
    "seeds": [
      "Intellectual developmental disorder with dysmorphic facies, speech delay, and T-cell abnormalities"
    ],
    "gold_answer": "Agenesis of maxillary lateral incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07602",
    "question": "What is associated with Acrocapitofemoral dysplasia?",
    "seeds": [
      "Acrocapitofemoral dysplasia"
    ],
    "gold_answer": "Abnormal rib morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07603",
    "question": "What is associated with Sclerosis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07604",
    "question": "What phenotype is associated with Paramolar tubercle of bolk?",
    "seeds": [
      "Paramolar tubercle of bolk"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07605",
    "question": "What is associated with Excessive eye contact?",
    "seeds": [
      "Excessive eye contact"
    ],
    "gold_answer": "Abnormal nonverbal communicative behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07606",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 110?",
    "seeds": [
      "Developmental and epileptic encephalopathy 110"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07607",
    "question": "What is associated with Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8?",
    "seeds": [
      "Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8"
    ],
    "gold_answer": "Decreased liver function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07608",
    "question": "What is associated with Myofiber disarray?",
    "seeds": [
      "Myofiber disarray"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07609",
    "question": "What phenotype is associated with MGAT2-CDG?",
    "seeds": [
      "MGAT2-CDG"
    ],
    "gold_answer": "Barrett esophagus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07610",
    "question": "What phenotype is associated with Fetal Gaucher disease?",
    "seeds": [
      "Fetal Gaucher disease"
    ],
    "gold_answer": "Pericardial effusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07611",
    "question": "What is associated with X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome?",
    "seeds": [
      "X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome"
    ],
    "gold_answer": "Abnormal nasal bridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07612",
    "question": "What is associated with Exostoses-anetodermia-brachydactyly type E syndrome?",
    "seeds": [
      "Exostoses-anetodermia-brachydactyly type E syndrome"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07613",
    "question": "What is associated with Polychromasia?",
    "seeds": [
      "Polychromasia"
    ],
    "gold_answer": "Abnormal reticulocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07614",
    "question": "What is associated with Isolated congenital laryngeal web?",
    "seeds": [
      "Isolated congenital laryngeal web"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07615",
    "question": "What is associated with Peritonitis?",
    "seeds": [
      "Peritonitis"
    ],
    "gold_answer": "Abnormal peritoneum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07616",
    "question": "What is associated with Inclusion body myositis?",
    "seeds": [
      "Inclusion body myositis"
    ],
    "gold_answer": "Abnormal circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07617",
    "question": "What phenotype is associated with Rolandic epilepsy-speech dyspraxia syndrome?",
    "seeds": [
      "Rolandic epilepsy-speech dyspraxia syndrome"
    ],
    "gold_answer": "Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07618",
    "question": "What phenotype is associated with SCHIZENCEPHALY?",
    "seeds": [
      "SCHIZENCEPHALY"
    ],
    "gold_answer": "Cerebral cortical atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07619",
    "question": "What is associated with Elevated circulating 2-trans,4-cis-decadienoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating 2-trans,4-cis-decadienoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating medium-chain acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07620",
    "question": "What is associated with Social disinhibition?",
    "seeds": [
      "Social disinhibition"
    ],
    "gold_answer": "Abnormal social behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07621",
    "question": "What is associated with Neonatal cholestatic liver disease?",
    "seeds": [
      "Neonatal cholestatic liver disease"
    ],
    "gold_answer": "Cholestatic liver disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07622",
    "question": "What is associated with Portal fibrosis?",
    "seeds": [
      "Portal fibrosis"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07623",
    "question": "What phenotype is associated with Spondyloepiphyseal dysplasia, Kondo-Fu type?",
    "seeds": [
      "Spondyloepiphyseal dysplasia, Kondo-Fu type"
    ],
    "gold_answer": "Inguinal hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07624",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 71, with behavioral abnormalities?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 71, with behavioral abnormalities"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07625",
    "question": "What is associated with Cutis verticis gyrata and mental deficiency?",
    "seeds": [
      "Cutis verticis gyrata and mental deficiency"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07626",
    "question": "What phenotype is associated with 1q41q42 microdeletion syndrome?",
    "seeds": [
      "1q41q42 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07627",
    "question": "What is associated with Incomplete unilateral cleft lip?",
    "seeds": [
      "Incomplete unilateral cleft lip"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07628",
    "question": "What is associated with Abnormal sensory nerve conduction velocity?",
    "seeds": [
      "Abnormal sensory nerve conduction velocity"
    ],
    "gold_answer": "Abnormality of peripheral nerve conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07629",
    "question": "What phenotype is associated with 15q11q13 microduplication syndrome?",
    "seeds": [
      "15q11q13 microduplication syndrome"
    ],
    "gold_answer": "Finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07630",
    "question": "What is associated with Abnormal pinhole visual acuity test?",
    "seeds": [
      "Abnormal pinhole visual acuity test"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07631",
    "question": "What is associated with Placental infarction?",
    "seeds": [
      "Placental infarction"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07632",
    "question": "What is associated with Neck pain?",
    "seeds": [
      "Neck pain"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07633",
    "question": "What is associated with Thoracic hemivertebrae?",
    "seeds": [
      "Thoracic hemivertebrae"
    ],
    "gold_answer": "Vertebral segmentation defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07634",
    "question": "What is associated with Hypodipsia?",
    "seeds": [
      "Hypodipsia"
    ],
    "gold_answer": "Abnormal consumption behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07635",
    "question": "What is associated with Bardet-Biedl syndrome 16?",
    "seeds": [
      "Bardet-Biedl syndrome 16"
    ],
    "gold_answer": "Abnormality of the amniotic fluid",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07636",
    "question": "What is associated with Isovaleric acid, inability to smell?",
    "seeds": [
      "Isovaleric acid, inability to smell"
    ],
    "gold_answer": "Abnormality of the sense of smell",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07637",
    "question": "What phenotype is associated with Bilateral polymicrogyria?",
    "seeds": [
      "Bilateral polymicrogyria"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07638",
    "question": "What is associated with Dilatation of Inferior mesenteric artery?",
    "seeds": [
      "Dilatation of Inferior mesenteric artery"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07639",
    "question": "What is associated with Maternal thrombophilia?",
    "seeds": [
      "Maternal thrombophilia"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07640",
    "question": "What is associated with Pigmented nodular adrenocortical disease, primary, 1?",
    "seeds": [
      "Pigmented nodular adrenocortical disease, primary, 1"
    ],
    "gold_answer": "Increased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07641",
    "question": "What is associated with Abnormal circulating testosterone concentration?",
    "seeds": [
      "Abnormal circulating testosterone concentration"
    ],
    "gold_answer": "Abnormal circulating sex hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07642",
    "question": "What is associated with Abnormal ear morphology?",
    "seeds": [
      "Abnormal ear morphology"
    ],
    "gold_answer": "Abnormality of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07643",
    "question": "What is associated with Palate telangiectasia?",
    "seeds": [
      "Palate telangiectasia"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07644",
    "question": "What is associated with Complete cleft maxillary alveolar ridge?",
    "seeds": [
      "Complete cleft maxillary alveolar ridge"
    ],
    "gold_answer": "Cleft maxillary alveolar ridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07645",
    "question": "What is associated with Sporadic pheochromocytoma/secreting paraganglioma?",
    "seeds": [
      "Sporadic pheochromocytoma/secreting paraganglioma"
    ],
    "gold_answer": "SDHB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_07646",
    "question": "What is associated with Hypoplasia of the femoral head?",
    "seeds": [
      "Hypoplasia of the femoral head"
    ],
    "gold_answer": "Abnormal femoral head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07647",
    "question": "What is associated with Bardet-Biedl syndrome 7?",
    "seeds": [
      "Bardet-Biedl syndrome 7"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07648",
    "question": "What is associated with Positive Hawkins test?",
    "seeds": [
      "Positive Hawkins test"
    ],
    "gold_answer": "Abnormal shoulder physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07649",
    "question": "What is associated with Immunodeficiency 53?",
    "seeds": [
      "Immunodeficiency 53"
    ],
    "gold_answer": "Abnormal neutrophil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07650",
    "question": "What phenotype is associated with Autosomal recessive cerebellar ataxia due to STUB1 deficiency?",
    "seeds": [
      "Autosomal recessive cerebellar ataxia due to STUB1 deficiency"
    ],
    "gold_answer": "Pancreatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07651",
    "question": "What is associated with Atrioventricular septal defect 5?",
    "seeds": [
      "Atrioventricular septal defect 5"
    ],
    "gold_answer": "Ventricular septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07652",
    "question": "What is associated with Pseudoautosomal recessive inheritance?",
    "seeds": [
      "Pseudoautosomal recessive inheritance"
    ],
    "gold_answer": "Mendelian inheritance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07653",
    "question": "What is associated with Partial duplication of the distal phalanx of the 5th finger?",
    "seeds": [
      "Partial duplication of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Partial duplication of the distal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07654",
    "question": "What is associated with Nonarteritic anterior ischemic optic neuropathy?",
    "seeds": [
      "Nonarteritic anterior ischemic optic neuropathy"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07655",
    "question": "What is associated with Positive Mazzotti test?",
    "seeds": [
      "Positive Mazzotti test"
    ],
    "gold_answer": "Positive skin infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07656",
    "question": "What is associated with Abnormal platelet ATP dense granule secretion?",
    "seeds": [
      "Abnormal platelet ATP dense granule secretion"
    ],
    "gold_answer": "Abnormal platelet function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07657",
    "question": "What is associated with Pseudoarthrosis?",
    "seeds": [
      "Pseudoarthrosis"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07658",
    "question": "What is associated with Abnormal cortical radial artery intima/media morphology?",
    "seeds": [
      "Abnormal cortical radial artery intima/media morphology"
    ],
    "gold_answer": "Abnormal renal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07659",
    "question": "What is associated with Focal autonomic seizure with pallor/flushing?",
    "seeds": [
      "Focal autonomic seizure with pallor/flushing"
    ],
    "gold_answer": "Focal autonomic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07660",
    "question": "What is associated with Decreased fertility in females?",
    "seeds": [
      "Decreased fertility in females"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07661",
    "question": "What is associated with Abnormal cutaneous elastic fiber morphology?",
    "seeds": [
      "Abnormal cutaneous elastic fiber morphology"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07662",
    "question": "What phenotype is associated with Seizures, benign familial infantile, 5?",
    "seeds": [
      "Seizures, benign familial infantile, 5"
    ],
    "gold_answer": "Paroxysmal dyskinesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07663",
    "question": "What is associated with Hypotrichosis with juvenile macular degeneration?",
    "seeds": [
      "Hypotrichosis with juvenile macular degeneration"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07664",
    "question": "What is associated with Monosomy 7 myelodysplasia and leukemia syndrome 2?",
    "seeds": [
      "Monosomy 7 myelodysplasia and leukemia syndrome 2"
    ],
    "gold_answer": "Hematological neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07665",
    "question": "What is associated with Subcortical localization?",
    "seeds": [
      "Subcortical localization"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07666",
    "question": "What phenotype is associated with Parkinsonism-dystonia 3, childhood-onset?",
    "seeds": [
      "Parkinsonism-dystonia 3, childhood-onset"
    ],
    "gold_answer": "Stooped posture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07667",
    "question": "What is associated with Hepatic vein thrombosis?",
    "seeds": [
      "Hepatic vein thrombosis"
    ],
    "gold_answer": "Abnormal thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07668",
    "question": "What is associated with Keratoderma, palmoplantar, punctate type IB?",
    "seeds": [
      "Keratoderma, palmoplantar, punctate type IB"
    ],
    "gold_answer": "Palmoplantar hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07669",
    "question": "What is associated with Isolated multiple intestinal atresia?",
    "seeds": [
      "Isolated multiple intestinal atresia"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07670",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 41?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 41"
    ],
    "gold_answer": "Long palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07671",
    "question": "What phenotype is associated with Melanoma, cutaneous malignant, susceptibility to, 3?",
    "seeds": [
      "Melanoma, cutaneous malignant, susceptibility to, 3"
    ],
    "gold_answer": "Atypical nevus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07672",
    "question": "What is associated with Anti-sp100 antibody positivity?",
    "seeds": [
      "Anti-sp100 antibody positivity"
    ],
    "gold_answer": "Anti-multiple nuclear dots antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07673",
    "question": "What is associated with Amniotic constriction ring?",
    "seeds": [
      "Amniotic constriction ring"
    ],
    "gold_answer": "Abnormal placental membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07674",
    "question": "What is associated with Nonopposable triphalangeal thumb?",
    "seeds": [
      "Nonopposable triphalangeal thumb"
    ],
    "gold_answer": "Triphalangeal thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07675",
    "question": "What is associated with Retinitis pigmentosa 55?",
    "seeds": [
      "Retinitis pigmentosa 55"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07676",
    "question": "What is associated with Absent circulating T cells?",
    "seeds": [
      "Absent circulating T cells"
    ],
    "gold_answer": "Abnormal lymphocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07677",
    "question": "What is associated with PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome?",
    "seeds": [
      "PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome"
    ],
    "gold_answer": "Abnormal morphology of the nasal alae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07678",
    "question": "What is associated with Panuveitis?",
    "seeds": [
      "Panuveitis"
    ],
    "gold_answer": "Inflammatory abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07679",
    "question": "What is associated with Elevated circulating insulin:C-peptide ratio?",
    "seeds": [
      "Elevated circulating insulin:C-peptide ratio"
    ],
    "gold_answer": "Abnormal circulating insulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07680",
    "question": "What is associated with Cochlear nerve aplasia?",
    "seeds": [
      "Cochlear nerve aplasia"
    ],
    "gold_answer": "Abnormality of the cochlear nerve",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07681",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 63, with macrocephaly?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 63, with macrocephaly"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07682",
    "question": "What is associated with Laryngeal abductor paralysis-intellectual disability syndrome?",
    "seeds": [
      "Laryngeal abductor paralysis-intellectual disability syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07683",
    "question": "What is associated with Anterior chamber cells grade 1+?",
    "seeds": [
      "Anterior chamber cells grade 1+"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07684",
    "question": "What is associated with Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency"
    ],
    "gold_answer": "DGUOK",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07685",
    "question": "What is associated with Interlobular bile duct destruction?",
    "seeds": [
      "Interlobular bile duct destruction"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07686",
    "question": "What is associated with Abnormality of external jugular vein?",
    "seeds": [
      "Abnormality of external jugular vein"
    ],
    "gold_answer": "Abnormal jugular vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07687",
    "question": "What is associated with Placenta percreta?",
    "seeds": [
      "Placenta percreta"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07688",
    "question": "What is associated with Periventricular laminar heterotopia?",
    "seeds": [
      "Periventricular laminar heterotopia"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07689",
    "question": "What phenotype is associated with Postencephalitic parkinsonism?",
    "seeds": [
      "Postencephalitic parkinsonism"
    ],
    "gold_answer": "Abnormal pyramidal sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07690",
    "question": "What is associated with Abasia?",
    "seeds": [
      "Abasia"
    ],
    "gold_answer": "Gait ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07691",
    "question": "What is associated with Focal impaired awareness autonomic seizure with erection?",
    "seeds": [
      "Focal impaired awareness autonomic seizure with erection"
    ],
    "gold_answer": "Focal impaired awareness autonomic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07692",
    "question": "What is associated with Cutaneous mastocytosis?",
    "seeds": [
      "Cutaneous mastocytosis"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07693",
    "question": "What is associated with Maxillary lateral incisor microdontia?",
    "seeds": [
      "Maxillary lateral incisor microdontia"
    ],
    "gold_answer": "Microdontia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07694",
    "question": "What is associated with Vertebra plana?",
    "seeds": [
      "Vertebra plana"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07695",
    "question": "What is associated with Steroid dehydrogenase deficiency-dental anomalies syndrome?",
    "seeds": [
      "Steroid dehydrogenase deficiency-dental anomalies syndrome"
    ],
    "gold_answer": "Abnormal number of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07696",
    "question": "What is associated with Elevated urinary 2,4-dihydroxyglutarate level?",
    "seeds": [
      "Elevated urinary 2,4-dihydroxyglutarate level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07697",
    "question": "What is associated with Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome?",
    "seeds": [
      "Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07698",
    "question": "What is associated with Reduced circulating reticulated platelet count?",
    "seeds": [
      "Reduced circulating reticulated platelet count"
    ],
    "gold_answer": "Abnormal platelet count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07699",
    "question": "What is associated with Abnormal circulating ethanolamine concentration?",
    "seeds": [
      "Abnormal circulating ethanolamine concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07700",
    "question": "What is associated with Adamantinoma of long bones?",
    "seeds": [
      "Adamantinoma of long bones"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07701",
    "question": "What is associated with Pigmented nodular adrenocortical disease, primary, 2?",
    "seeds": [
      "Pigmented nodular adrenocortical disease, primary, 2"
    ],
    "gold_answer": "Increased blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07702",
    "question": "What is associated with Irreversible airflow obstruction?",
    "seeds": [
      "Irreversible airflow obstruction"
    ],
    "gold_answer": "Airway obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07703",
    "question": "What is associated with Blepharophimosis-ptosis-epicanthus inversus syndrome?",
    "seeds": [
      "Blepharophimosis-ptosis-epicanthus inversus syndrome"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07704",
    "question": "What is associated with Unilateral absence of pectoralis major muscle?",
    "seeds": [
      "Unilateral absence of pectoralis major muscle"
    ],
    "gold_answer": "Abnormality of the musculature of the thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07705",
    "question": "What is associated with Subcutaneous ossification?",
    "seeds": [
      "Subcutaneous ossification"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07706",
    "question": "What is associated with Rib segmentation abnormalities?",
    "seeds": [
      "Rib segmentation abnormalities"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07707",
    "question": "What is associated with Empty sella turcica?",
    "seeds": [
      "Empty sella turcica"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07708",
    "question": "What is associated with Kaposiform hemangioendothelioma?",
    "seeds": [
      "Kaposiform hemangioendothelioma"
    ],
    "gold_answer": "Abnormality of skin adnexa physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07709",
    "question": "What is associated with Anti-Ro/SS-A antibody positivity?",
    "seeds": [
      "Anti-Ro/SS-A antibody positivity"
    ],
    "gold_answer": "Extractable nuclear antigen positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07710",
    "question": "What is associated with Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation?",
    "seeds": [
      "Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation"
    ],
    "gold_answer": "KIF5A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07711",
    "question": "What is associated with Lactescent serum?",
    "seeds": [
      "Lactescent serum"
    ],
    "gold_answer": "Hyperlipidemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07712",
    "question": "What is associated with Profound global developmental delay?",
    "seeds": [
      "Profound global developmental delay"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07713",
    "question": "What is associated with Vaginal hematocele?",
    "seeds": [
      "Vaginal hematocele"
    ],
    "gold_answer": "Abnormal scrotum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07714",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 76?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 76"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07715",
    "question": "What phenotype is associated with Conotruncal heart malformations?",
    "seeds": [
      "Conotruncal heart malformations"
    ],
    "gold_answer": "Stroke",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07716",
    "question": "What phenotype is associated with Neurodevelopmental disorder with microcephaly, ataxia, and seizures?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, ataxia, and seizures"
    ],
    "gold_answer": "Moderate intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07717",
    "question": "What is associated with Wide nasal bridge?",
    "seeds": [
      "Wide nasal bridge"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07718",
    "question": "What is associated with Digital extensor muscle aplasia-polyneuropathy?",
    "seeds": [
      "Digital extensor muscle aplasia-polyneuropathy"
    ],
    "gold_answer": "Interphalangeal joint contracture of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07719",
    "question": "What is associated with Cardiac amyloidosis?",
    "seeds": [
      "Cardiac amyloidosis"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07720",
    "question": "What is associated with Abnormal scapula morphology?",
    "seeds": [
      "Abnormal scapula morphology"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07721",
    "question": "What is associated with Spermatogonial maturation arrest?",
    "seeds": [
      "Spermatogonial maturation arrest"
    ],
    "gold_answer": "Spermatogenesis maturation arrest",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07722",
    "question": "What is associated with Periorbital dermoid cyst?",
    "seeds": [
      "Periorbital dermoid cyst"
    ],
    "gold_answer": "Orbital cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07723",
    "question": "What is associated with Aromatase deficiency?",
    "seeds": [
      "Aromatase deficiency"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07724",
    "question": "What is associated with Generalized neonatal hypotonia?",
    "seeds": [
      "Generalized neonatal hypotonia"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07725",
    "question": "What is associated with Combined cystic and ground-glass pattern on pulmonary HRCT?",
    "seeds": [
      "Combined cystic and ground-glass pattern on pulmonary HRCT"
    ],
    "gold_answer": "Pulmonary opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07726",
    "question": "What is associated with Lateral displacement of patellae?",
    "seeds": [
      "Lateral displacement of patellae"
    ],
    "gold_answer": "Abnormal patella morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07727",
    "question": "What is associated with Aplasia/Hypoplasia of the 2nd finger?",
    "seeds": [
      "Aplasia/Hypoplasia of the 2nd finger"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07728",
    "question": "What is associated with Abnormality of the distal fibular epiphysis?",
    "seeds": [
      "Abnormality of the distal fibular epiphysis"
    ],
    "gold_answer": "Abnormal lower limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07729",
    "question": "What is associated with Aplasia of the pyramids of the medulla oblongata?",
    "seeds": [
      "Aplasia of the pyramids of the medulla oblongata"
    ],
    "gold_answer": "Abnormal hindbrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07730",
    "question": "What phenotype is associated with Congenital heart defects, multiple types, 8, with or without heterotaxy?",
    "seeds": [
      "Congenital heart defects, multiple types, 8, with or without heterotaxy"
    ],
    "gold_answer": "Left superior vena cava draining directly to the left atrium",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07731",
    "question": "What phenotype is associated with Split-Hand/foot malformation 2?",
    "seeds": [
      "Split-Hand/foot malformation 2"
    ],
    "gold_answer": "Split hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07732",
    "question": "What is associated with Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8?",
    "seeds": [
      "Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8"
    ],
    "gold_answer": "Severe infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07733",
    "question": "What is associated with Spermatogenic failure 8?",
    "seeds": [
      "Spermatogenic failure 8"
    ],
    "gold_answer": "Abnormal spermatogenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07734",
    "question": "What is associated with Abnormality of skin physiology?",
    "seeds": [
      "Abnormality of skin physiology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07735",
    "question": "What is associated with Absent smooth pursuit?",
    "seeds": [
      "Absent smooth pursuit"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07736",
    "question": "What is associated with Calcaneal epiphyseal stippling?",
    "seeds": [
      "Calcaneal epiphyseal stippling"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07737",
    "question": "What is associated with Lipoyltransferase 1 deficiency?",
    "seeds": [
      "Lipoyltransferase 1 deficiency"
    ],
    "gold_answer": "Tetraplegia/tetraparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07738",
    "question": "What is associated with Sclerosis of 3rd finger phalanx?",
    "seeds": [
      "Sclerosis of 3rd finger phalanx"
    ],
    "gold_answer": "Abnormal 3rd finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07739",
    "question": "What is associated with Focal impaired awareness emotional seizure with anger?",
    "seeds": [
      "Focal impaired awareness emotional seizure with anger"
    ],
    "gold_answer": "Focal impaired awareness non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07740",
    "question": "What is associated with Abnormal adrenal morphology?",
    "seeds": [
      "Abnormal adrenal morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07741",
    "question": "What is associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome 4?",
    "seeds": [
      "Megacystis-microcolon-intestinal hypoperistalsis syndrome 4"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07742",
    "question": "What is associated with Decreased urine urobilinogen?",
    "seeds": [
      "Decreased urine urobilinogen"
    ],
    "gold_answer": "Abnormal urinary organic compound level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07743",
    "question": "What is associated with Hypouricemia, renal, 2?",
    "seeds": [
      "Hypouricemia, renal, 2"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07744",
    "question": "What phenotype is associated with Acetazolamide-responsive myotonia?",
    "seeds": [
      "Acetazolamide-responsive myotonia"
    ],
    "gold_answer": "Hypothyroidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07745",
    "question": "What is associated with Ceroid lipofuscinosis, neuronal, 6B (Kufs type)?",
    "seeds": [
      "Ceroid lipofuscinosis, neuronal, 6B (Kufs type)"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07746",
    "question": "What is associated with Increased neutrophil mitochondria?",
    "seeds": [
      "Increased neutrophil mitochondria"
    ],
    "gold_answer": "Abnormality of neutrophils",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07747",
    "question": "What is associated with Supravalvular aortic stenosis?",
    "seeds": [
      "Supravalvular aortic stenosis"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07748",
    "question": "What is associated with Low tissue non-specific alkaline phosphatase?",
    "seeds": [
      "Low tissue non-specific alkaline phosphatase"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07749",
    "question": "What is associated with Streak gonad?",
    "seeds": [
      "Streak gonad"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07750",
    "question": "What is associated with Acute bronchitis?",
    "seeds": [
      "Acute bronchitis"
    ],
    "gold_answer": "Bronchitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07751",
    "question": "What is associated with Quadriceps muscle weakness?",
    "seeds": [
      "Quadriceps muscle weakness"
    ],
    "gold_answer": "Proximal muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07752",
    "question": "What is associated with Spina bifida occulta?",
    "seeds": [
      "Spina bifida occulta"
    ],
    "gold_answer": "Spinal dysraphism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07753",
    "question": "What is associated with Chronic beryllium disease?",
    "seeds": [
      "Chronic beryllium disease"
    ],
    "gold_answer": "Abnormal pharynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07754",
    "question": "What is associated with Lunotriquetral ligament tear?",
    "seeds": [
      "Lunotriquetral ligament tear"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07755",
    "question": "What is associated with Arcuate vein medial/intimal liquefactive necrosis?",
    "seeds": [
      "Arcuate vein medial/intimal liquefactive necrosis"
    ],
    "gold_answer": "Abnormal arcuate vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07756",
    "question": "What is associated with Macroorchidism, postpubertal?",
    "seeds": [
      "Macroorchidism, postpubertal"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07757",
    "question": "What is associated with Elevated osmolality gap?",
    "seeds": [
      "Elevated osmolality gap"
    ],
    "gold_answer": "Abnormal serum osmolality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07758",
    "question": "What is associated with Ambiguous genitalia?",
    "seeds": [
      "Ambiguous genitalia"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07759",
    "question": "What is associated with Abnormal morphology of the limbic system?",
    "seeds": [
      "Abnormal morphology of the limbic system"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07760",
    "question": "What is associated with Adams-Oliver syndrome 4?",
    "seeds": [
      "Adams-Oliver syndrome 4"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07761",
    "question": "What phenotype is associated with Immunodeficiency due to defect in mapbp-interacting protein?",
    "seeds": [
      "Immunodeficiency due to defect in mapbp-interacting protein"
    ],
    "gold_answer": "Decreased circulating total IgM",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07762",
    "question": "What is associated with Ornithine transcarbamylase deficiency, hyperammonemia due to?",
    "seeds": [
      "Ornithine transcarbamylase deficiency, hyperammonemia due to"
    ],
    "gold_answer": "Abnormal emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07763",
    "question": "What is associated with Deafness, autosomal dominant 88?",
    "seeds": [
      "Deafness, autosomal dominant 88"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07764",
    "question": "What is associated with Coiled sperm flagella?",
    "seeds": [
      "Coiled sperm flagella"
    ],
    "gold_answer": "Abnormal male germ cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07765",
    "question": "What phenotype is associated with Short stature, Dauber-Argente type?",
    "seeds": [
      "Short stature, Dauber-Argente type"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07766",
    "question": "What is associated with Joubert syndrome 3?",
    "seeds": [
      "Joubert syndrome 3"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07767",
    "question": "What phenotype is associated with Pelvis-shoulder dysplasia?",
    "seeds": [
      "Pelvis-shoulder dysplasia"
    ],
    "gold_answer": "Spastic diplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07768",
    "question": "What is associated with Accessory navicular bone?",
    "seeds": [
      "Accessory navicular bone"
    ],
    "gold_answer": "Abnormality of the tarsal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07769",
    "question": "What is associated with Sneeze?",
    "seeds": [
      "Sneeze"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07770",
    "question": "What is associated with Anti-factor IX antibody positivity?",
    "seeds": [
      "Anti-factor IX antibody positivity"
    ],
    "gold_answer": "Anti-coagulation factor antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07771",
    "question": "What is associated with Distal femoral bowing?",
    "seeds": [
      "Distal femoral bowing"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07772",
    "question": "What is associated with Leukoencephalopathy with calcifications and cysts?",
    "seeds": [
      "Leukoencephalopathy with calcifications and cysts"
    ],
    "gold_answer": "Intracranial hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07773",
    "question": "What is associated with Peroxisome biogenesis disorder 1A (Zellweger)?",
    "seeds": [
      "Peroxisome biogenesis disorder 1A (Zellweger)"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07774",
    "question": "What is associated with 2-4 finger cutaneous syndactyly?",
    "seeds": [
      "2-4 finger cutaneous syndactyly"
    ],
    "gold_answer": "Cutaneous finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07775",
    "question": "What is associated with Excessive cerumen?",
    "seeds": [
      "Excessive cerumen"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07776",
    "question": "What is associated with Early onset of sexual maturation?",
    "seeds": [
      "Early onset of sexual maturation"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07777",
    "question": "What is associated with Elevated urinary isovaleric acid level?",
    "seeds": [
      "Elevated urinary isovaleric acid level"
    ],
    "gold_answer": "Abnormal urine pH",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07778",
    "question": "What is associated with Secondary Caesarian section?",
    "seeds": [
      "Secondary Caesarian section"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07779",
    "question": "What is associated with Immunodeficiency 25?",
    "seeds": [
      "Immunodeficiency 25"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07780",
    "question": "What phenotype is associated with Shashi-Pena syndrome?",
    "seeds": [
      "Shashi-Pena syndrome"
    ],
    "gold_answer": "Mild fetal ventriculomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07781",
    "question": "What is associated with Pulmonary nodular lymphoid hyperplasia?",
    "seeds": [
      "Pulmonary nodular lymphoid hyperplasia"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07782",
    "question": "What is associated with Paralysis?",
    "seeds": [
      "Paralysis"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07783",
    "question": "What is associated with Atrial septal defect, ostium secundum type?",
    "seeds": [
      "Atrial septal defect, ostium secundum type"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07784",
    "question": "What is associated with Abnormal P50/N95 ratio of pattern electroretinogram?",
    "seeds": [
      "Abnormal P50/N95 ratio of pattern electroretinogram"
    ],
    "gold_answer": "Abnormal pattern electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07785",
    "question": "What is associated with Vascular calcification?",
    "seeds": [
      "Vascular calcification"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07786",
    "question": "What phenotype is associated with Patterson-Stevenson-Fontaine syndrome?",
    "seeds": [
      "Patterson-Stevenson-Fontaine syndrome"
    ],
    "gold_answer": "Dental crowding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07787",
    "question": "What is associated with Cone dystrophy 4?",
    "seeds": [
      "Cone dystrophy 4"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07788",
    "question": "What is associated with Polydactyly affecting the 2nd finger?",
    "seeds": [
      "Polydactyly affecting the 2nd finger"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07789",
    "question": "What is associated with Neonatal inspiratory stridor?",
    "seeds": [
      "Neonatal inspiratory stridor"
    ],
    "gold_answer": "Stridor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07790",
    "question": "What is associated with Neologism?",
    "seeds": [
      "Neologism"
    ],
    "gold_answer": "Abnormal semantics",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07791",
    "question": "What phenotype is associated with Pseudohypoaldosteronism, type IID?",
    "seeds": [
      "Pseudohypoaldosteronism, type IID"
    ],
    "gold_answer": "Pseudohypoaldosteronism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07792",
    "question": "What is associated with Familial dilated cardiomyopathy with conduction defect due to LMNA mutation?",
    "seeds": [
      "Familial dilated cardiomyopathy with conduction defect due to LMNA mutation"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07793",
    "question": "What phenotype is associated with Aicardi-Goutières syndrome?",
    "seeds": [
      "Aicardi-Goutières syndrome"
    ],
    "gold_answer": "Prolonged neonatal jaundice",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07794",
    "question": "What is associated with Left ventricular dilatation?",
    "seeds": [
      "Left ventricular dilatation"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07795",
    "question": "What is associated with Behavioral variant of frontotemporal dementia?",
    "seeds": [
      "Behavioral variant of frontotemporal dementia"
    ],
    "gold_answer": "VCP",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_07796",
    "question": "What is associated with Abnormality of palatopharyngeus muscle?",
    "seeds": [
      "Abnormality of palatopharyngeus muscle"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07797",
    "question": "What is associated with Elevated serum 11-deoxycortisol?",
    "seeds": [
      "Elevated serum 11-deoxycortisol"
    ],
    "gold_answer": "Abnormality of adrenal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07798",
    "question": "What is associated with Prominent antitragus?",
    "seeds": [
      "Prominent antitragus"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07799",
    "question": "What is associated with Combined hamartoma of the retina and retinal pigment epithelium?",
    "seeds": [
      "Combined hamartoma of the retina and retinal pigment epithelium"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07800",
    "question": "What is associated with Duplication of phalanx of toe?",
    "seeds": [
      "Duplication of phalanx of toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07801",
    "question": "What is associated with Abnormal vena cava morphology?",
    "seeds": [
      "Abnormal vena cava morphology"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07802",
    "question": "What phenotype is associated with Ohdo syndrome, X-linked?",
    "seeds": [
      "Ohdo syndrome, X-linked"
    ],
    "gold_answer": "Posteriorly rotated ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07803",
    "question": "What is associated with Increased total T cell count?",
    "seeds": [
      "Increased total T cell count"
    ],
    "gold_answer": "Abnormal total T cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07804",
    "question": "What is associated with Ileal adenocarcinoma?",
    "seeds": [
      "Ileal adenocarcinoma"
    ],
    "gold_answer": "Gastrointestinal carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07805",
    "question": "What is associated with Multiple joint contractures?",
    "seeds": [
      "Multiple joint contractures"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07806",
    "question": "What is associated with Abnormal heart valve physiology?",
    "seeds": [
      "Abnormal heart valve physiology"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07807",
    "question": "What is associated with Hypoplastic lacrimal duct?",
    "seeds": [
      "Hypoplastic lacrimal duct"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07808",
    "question": "What is associated with Cyclic neutropenia?",
    "seeds": [
      "Cyclic neutropenia"
    ],
    "gold_answer": "Inflammation of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07809",
    "question": "What is associated with Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome?",
    "seeds": [
      "Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07810",
    "question": "What phenotype is associated with Deafness, autosomal recessive 115?",
    "seeds": [
      "Deafness, autosomal recessive 115"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07811",
    "question": "What is associated with Juvenile nephropathic cystinosis?",
    "seeds": [
      "Juvenile nephropathic cystinosis"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07812",
    "question": "What is associated with Fibrosis, neurodegeneration, and cerebral angiomatosis?",
    "seeds": [
      "Fibrosis, neurodegeneration, and cerebral angiomatosis"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07813",
    "question": "What phenotype is associated with Zollinger-Ellison syndrome?",
    "seeds": [
      "Zollinger-Ellison syndrome"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07814",
    "question": "What is associated with Pili canaliculi?",
    "seeds": [
      "Pili canaliculi"
    ],
    "gold_answer": "Abnormal hairshaft morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07815",
    "question": "What phenotype is associated with Immunodeficiency 11B with atopic dermatitis?",
    "seeds": [
      "Immunodeficiency 11B with atopic dermatitis"
    ],
    "gold_answer": "Bronchiectasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07816",
    "question": "What phenotype is associated with Aspergillosis?",
    "seeds": [
      "Aspergillosis"
    ],
    "gold_answer": "Abnormality of long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07817",
    "question": "What is associated with Cerulean cataract?",
    "seeds": [
      "Cerulean cataract"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07818",
    "question": "What is associated with Tooth malformation?",
    "seeds": [
      "Tooth malformation"
    ],
    "gold_answer": "Abnormal number of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07819",
    "question": "What phenotype is associated with Brachydactyly-Ectrodactyly with fibular aplasia or hypoplasia?",
    "seeds": [
      "Brachydactyly-Ectrodactyly with fibular aplasia or hypoplasia"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07820",
    "question": "What is associated with Elevated urinary thymine level?",
    "seeds": [
      "Elevated urinary thymine level"
    ],
    "gold_answer": "Abnormal urinary pyrimidine level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07821",
    "question": "What is associated with Fractured hand bones?",
    "seeds": [
      "Fractured hand bones"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07822",
    "question": "What is associated with Retropharyngeal hemangioma?",
    "seeds": [
      "Retropharyngeal hemangioma"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07823",
    "question": "What is associated with EEG with generalized slow activity grade 3?",
    "seeds": [
      "EEG with generalized slow activity grade 3"
    ],
    "gold_answer": "EEG with generalized slow activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07824",
    "question": "What phenotype is associated with Phosphohydroxylysinuria?",
    "seeds": [
      "Phosphohydroxylysinuria"
    ],
    "gold_answer": "Elevated urinary phosphohydroxylysine level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07825",
    "question": "What is associated with Silver-Russell syndrome due to 11p15 microduplication?",
    "seeds": [
      "Silver-Russell syndrome due to 11p15 microduplication"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07826",
    "question": "What phenotype is associated with Crigler-Najjar syndrome type 1?",
    "seeds": [
      "Crigler-Najjar syndrome type 1"
    ],
    "gold_answer": "Memory impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07827",
    "question": "What is associated with Ainhum?",
    "seeds": [
      "Ainhum"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07828",
    "question": "What phenotype is associated with Familial focal epilepsy with variable foci?",
    "seeds": [
      "Familial focal epilepsy with variable foci"
    ],
    "gold_answer": "Flushing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07829",
    "question": "What phenotype is associated with Orofaciodigital syndrome VI?",
    "seeds": [
      "Orofaciodigital syndrome VI"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07830",
    "question": "What is associated with Proliferating trichilemmal cyst?",
    "seeds": [
      "Proliferating trichilemmal cyst"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07831",
    "question": "What is associated with Abnormal horizontal rectus muscle physiology?",
    "seeds": [
      "Abnormal horizontal rectus muscle physiology"
    ],
    "gold_answer": "Abnormal extraocular muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07832",
    "question": "What is associated with Familial Alzheimer-like prion disease?",
    "seeds": [
      "Familial Alzheimer-like prion disease"
    ],
    "gold_answer": "Short term memory impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07833",
    "question": "What is associated with Reflex tearing?",
    "seeds": [
      "Reflex tearing"
    ],
    "gold_answer": "Lacrimation abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07834",
    "question": "What is associated with Cryptogenic multifocal ulcerous stenosing enteritis?",
    "seeds": [
      "Cryptogenic multifocal ulcerous stenosing enteritis"
    ],
    "gold_answer": "PLA2G4A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_07835",
    "question": "What is associated with Elevated brain creatine level by MRS?",
    "seeds": [
      "Elevated brain creatine level by MRS"
    ],
    "gold_answer": "Brain imaging abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07836",
    "question": "What is associated with Otosclerosis 4?",
    "seeds": [
      "Otosclerosis 4"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07837",
    "question": "What is associated with Aplasia/Hypoplasia of the cochlea?",
    "seeds": [
      "Aplasia/Hypoplasia of the cochlea"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07838",
    "question": "What is associated with Narrow nasal ridge?",
    "seeds": [
      "Narrow nasal ridge"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07839",
    "question": "What is associated with Unaided visual acuity 0.7 LogMAR?",
    "seeds": [
      "Unaided visual acuity 0.7 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07840",
    "question": "What is associated with Disproportionate tall stature?",
    "seeds": [
      "Disproportionate tall stature"
    ],
    "gold_answer": "Tall stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07841",
    "question": "What phenotype is associated with Herpes simplex virus encephalitis?",
    "seeds": [
      "Herpes simplex virus encephalitis"
    ],
    "gold_answer": "Alcoholism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07842",
    "question": "What is associated with Truncus arteriosus?",
    "seeds": [
      "Truncus arteriosus"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07843",
    "question": "What is associated with Abnormality of primary teeth?",
    "seeds": [
      "Abnormality of primary teeth"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07844",
    "question": "What is associated with Abnormal ossification of the sacrum?",
    "seeds": [
      "Abnormal ossification of the sacrum"
    ],
    "gold_answer": "Abnormal sacrum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07845",
    "question": "What is associated with Triose phosphate-isomerase deficiency?",
    "seeds": [
      "Triose phosphate-isomerase deficiency"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07846",
    "question": "What is associated with Abnormal metaphyseal vascular invasion?",
    "seeds": [
      "Abnormal metaphyseal vascular invasion"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07847",
    "question": "What phenotype is associated with Coronary artery dissection, spontaneous?",
    "seeds": [
      "Coronary artery dissection, spontaneous"
    ],
    "gold_answer": "Cystic medial necrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07848",
    "question": "What is associated with Trichothiodystrophy 1, photosensitive?",
    "seeds": [
      "Trichothiodystrophy 1, photosensitive"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07849",
    "question": "What is associated with Verrucous papule?",
    "seeds": [
      "Verrucous papule"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07850",
    "question": "What is associated with Increased globoside Gb4 level?",
    "seeds": [
      "Increased globoside Gb4 level"
    ],
    "gold_answer": "Abnormal glycosphingolipid metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07851",
    "question": "What is associated with Hydropic placenta?",
    "seeds": [
      "Hydropic placenta"
    ],
    "gold_answer": "Abnormal placental size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07852",
    "question": "What is associated with Bacteriuria?",
    "seeds": [
      "Bacteriuria"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07853",
    "question": "What phenotype is associated with Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development?",
    "seeds": [
      "Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development"
    ],
    "gold_answer": "Simplified gyral pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07854",
    "question": "What is associated with Decreased fecal pH?",
    "seeds": [
      "Decreased fecal pH"
    ],
    "gold_answer": "Abnormal stool composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07855",
    "question": "What is associated with Focal sensory seizure with somatosensory features?",
    "seeds": [
      "Focal sensory seizure with somatosensory features"
    ],
    "gold_answer": "Focal sensory seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07856",
    "question": "What is associated with Spastic ataxia?",
    "seeds": [
      "Spastic ataxia"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07857",
    "question": "What is associated with Intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism?",
    "seeds": [
      "Intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07858",
    "question": "What is associated with Intraepidermal microabscess formation?",
    "seeds": [
      "Intraepidermal microabscess formation"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07859",
    "question": "What is associated with Hypoplastic pubic ramus?",
    "seeds": [
      "Hypoplastic pubic ramus"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07860",
    "question": "What is associated with Delayed femoral head ossification?",
    "seeds": [
      "Delayed femoral head ossification"
    ],
    "gold_answer": "Abnormal enchondral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07861",
    "question": "What is associated with Partial duplication of the distal phalanx of the 2nd finger?",
    "seeds": [
      "Partial duplication of the distal phalanx of the 2nd finger"
    ],
    "gold_answer": "Partial duplication of the phalanges of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07862",
    "question": "What is associated with Abnormal TSH response to thyrotrophin-releasing hormone stimulation test?",
    "seeds": [
      "Abnormal TSH response to thyrotrophin-releasing hormone stimulation test"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07863",
    "question": "What is associated with Anti-ganglioside antibody positivity?",
    "seeds": [
      "Anti-ganglioside antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07864",
    "question": "What is associated with Familial calcium pyrophosphate deposition?",
    "seeds": [
      "Familial calcium pyrophosphate deposition"
    ],
    "gold_answer": "Abnormality of temperature regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07865",
    "question": "What is associated with Tongue, pigmented fungiform papillae of?",
    "seeds": [
      "Tongue, pigmented fungiform papillae of"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07866",
    "question": "What is associated with Abnormal pubic bone morphology?",
    "seeds": [
      "Abnormal pubic bone morphology"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07867",
    "question": "What phenotype is associated with D-2-hydroxyglutaric aciduria 2?",
    "seeds": [
      "D-2-hydroxyglutaric aciduria 2"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07868",
    "question": "What is associated with Nephronophthisis?",
    "seeds": [
      "Nephronophthisis"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07869",
    "question": "What is associated with Burkitt lymphoma?",
    "seeds": [
      "Burkitt lymphoma"
    ],
    "gold_answer": "Non-Hodgkin lymphoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07870",
    "question": "What phenotype is associated with Lipodystrophy, congenital generalized, type 4?",
    "seeds": [
      "Lipodystrophy, congenital generalized, type 4"
    ],
    "gold_answer": "Flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07871",
    "question": "What is associated with Cutis laxa, autosomal recessive, type ID?",
    "seeds": [
      "Cutis laxa, autosomal recessive, type ID"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07872",
    "question": "What is associated with Psychotic episodes?",
    "seeds": [
      "Psychotic episodes"
    ],
    "gold_answer": "Abnormal psychotic pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07873",
    "question": "What is associated with Warty dyskeratoma?",
    "seeds": [
      "Warty dyskeratoma"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07874",
    "question": "What is associated with Bowdler spurs?",
    "seeds": [
      "Bowdler spurs"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07875",
    "question": "What is associated with Irregular epiphyses?",
    "seeds": [
      "Irregular epiphyses"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07876",
    "question": "What is associated with Trigger thumb?",
    "seeds": [
      "Trigger thumb"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07877",
    "question": "What is associated with Abnormal platelet dense granule secretion?",
    "seeds": [
      "Abnormal platelet dense granule secretion"
    ],
    "gold_answer": "Abnormality of thrombocytes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07878",
    "question": "What is associated with Arthrogryposis multiplex congenita 7, X-linked?",
    "seeds": [
      "Arthrogryposis multiplex congenita 7, X-linked"
    ],
    "gold_answer": "Craniofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07879",
    "question": "What is associated with Elevated circulating glutaric acid concentration?",
    "seeds": [
      "Elevated circulating glutaric acid concentration"
    ],
    "gold_answer": "Abnormal circulating dicarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07880",
    "question": "What is associated with Ulnar deviation of the 2nd finger?",
    "seeds": [
      "Ulnar deviation of the 2nd finger"
    ],
    "gold_answer": "Ulnar deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07881",
    "question": "What phenotype is associated with Localized junctional epidermolysis bullosa?",
    "seeds": [
      "Localized junctional epidermolysis bullosa"
    ],
    "gold_answer": "Acral blistering",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07882",
    "question": "What is associated with Impaired cerebroside sulfate hydrolysis?",
    "seeds": [
      "Impaired cerebroside sulfate hydrolysis"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07883",
    "question": "What is associated with Abnormal response to insulin tolerance test?",
    "seeds": [
      "Abnormal response to insulin tolerance test"
    ],
    "gold_answer": "Abnormal endocrine physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07884",
    "question": "What is associated with Positive direct antiglobulin test?",
    "seeds": [
      "Positive direct antiglobulin test"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07885",
    "question": "What phenotype is associated with Malignant peritoneal mesothelioma?",
    "seeds": [
      "Malignant peritoneal mesothelioma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07886",
    "question": "What phenotype is associated with Warburg micro syndrome 3?",
    "seeds": [
      "Warburg micro syndrome 3"
    ],
    "gold_answer": "Hypoplastic labia minora",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07887",
    "question": "What is associated with Immunodeficiency 62?",
    "seeds": [
      "Immunodeficiency 62"
    ],
    "gold_answer": "Abnormal total B cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07888",
    "question": "What is associated with Malignant hyperthermia, susceptibility to, 2?",
    "seeds": [
      "Malignant hyperthermia, susceptibility to, 2"
    ],
    "gold_answer": "Abnormal circulating potassium concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07889",
    "question": "What is associated with Hand pain?",
    "seeds": [
      "Hand pain"
    ],
    "gold_answer": "Upper limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07890",
    "question": "What is associated with Deafness, autosomal recessive 97?",
    "seeds": [
      "Deafness, autosomal recessive 97"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07891",
    "question": "What is associated with Abnormal bladder morphology?",
    "seeds": [
      "Abnormal bladder morphology"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07892",
    "question": "What phenotype is associated with Epithelial recurrent erosion dystrophy?",
    "seeds": [
      "Epithelial recurrent erosion dystrophy"
    ],
    "gold_answer": "Recurrent corneal erosions",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07893",
    "question": "What is associated with Xeroderma pigmentosum, variant type?",
    "seeds": [
      "Xeroderma pigmentosum, variant type"
    ],
    "gold_answer": "Melanoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07894",
    "question": "What is associated with Triangular shaped middle phalanx of the 2nd toe?",
    "seeds": [
      "Triangular shaped middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal 2nd toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07895",
    "question": "What is associated with Reduced antral follicle count?",
    "seeds": [
      "Reduced antral follicle count"
    ],
    "gold_answer": "Abnormal female reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07896",
    "question": "What is associated with Recurrent lower respiratory tract infections?",
    "seeds": [
      "Recurrent lower respiratory tract infections"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07897",
    "question": "What is associated with Positive stool giardia antigen?",
    "seeds": [
      "Positive stool giardia antigen"
    ],
    "gold_answer": "Abnormal stool composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07898",
    "question": "What is associated with Hypoplasia of the corpus callosum?",
    "seeds": [
      "Hypoplasia of the corpus callosum"
    ],
    "gold_answer": "Thin corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07899",
    "question": "What is associated with Abnormality of the temporomandibular joint?",
    "seeds": [
      "Abnormality of the temporomandibular joint"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07900",
    "question": "What phenotype is associated with Parkinsonism-dystonia 3, childhood-onset?",
    "seeds": [
      "Parkinsonism-dystonia 3, childhood-onset"
    ],
    "gold_answer": "Global brain atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07901",
    "question": "What is associated with Broad radius?",
    "seeds": [
      "Broad radius"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07902",
    "question": "What is associated with Accelerated atherosclerosis?",
    "seeds": [
      "Accelerated atherosclerosis"
    ],
    "gold_answer": "Arteriosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07903",
    "question": "What phenotype is associated with Immunodeficiency 112?",
    "seeds": [
      "Immunodeficiency 112"
    ],
    "gold_answer": "Hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07904",
    "question": "What is associated with Portal hypertension?",
    "seeds": [
      "Portal hypertension"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07905",
    "question": "What phenotype is associated with Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity?",
    "seeds": [
      "Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity"
    ],
    "gold_answer": "Dysarthria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07906",
    "question": "What is associated with Drowsiness?",
    "seeds": [
      "Drowsiness"
    ],
    "gold_answer": "Reduced consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07907",
    "question": "What is associated with Olivopontocerebellar hypoplasia?",
    "seeds": [
      "Olivopontocerebellar hypoplasia"
    ],
    "gold_answer": "Cerebellar hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07908",
    "question": "What is associated with Spontaneous periodic hypothermia?",
    "seeds": [
      "Spontaneous periodic hypothermia"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07909",
    "question": "What is associated with Palmar hyperkeratosis?",
    "seeds": [
      "Palmar hyperkeratosis"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07910",
    "question": "What is associated with Late-onset distal muscle weakness?",
    "seeds": [
      "Late-onset distal muscle weakness"
    ],
    "gold_answer": "Distal muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07911",
    "question": "What is associated with Cerebellar dysfunction with variable cognitive and behavioral abnormalities?",
    "seeds": [
      "Cerebellar dysfunction with variable cognitive and behavioral abnormalities"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07912",
    "question": "What is associated with Hamartoma of tongue?",
    "seeds": [
      "Hamartoma of tongue"
    ],
    "gold_answer": "Neoplasm of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07913",
    "question": "What is associated with GROWTH CONTROL, Y-CHROMOSOME INFLUENCED?",
    "seeds": [
      "GROWTH CONTROL, Y-CHROMOSOME INFLUENCED"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07914",
    "question": "What is associated with Olfactory lobe agenesis?",
    "seeds": [
      "Olfactory lobe agenesis"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07915",
    "question": "What is associated with Mast syndrome?",
    "seeds": [
      "Mast syndrome"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07916",
    "question": "What is associated with Curry-Jones syndrome?",
    "seeds": [
      "Curry-Jones syndrome"
    ],
    "gold_answer": "AKT3",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07917",
    "question": "What is associated with Diabetes insipidus, Neurohypophyseal type?",
    "seeds": [
      "Diabetes insipidus, Neurohypophyseal type"
    ],
    "gold_answer": "Abnormality of globe location",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07918",
    "question": "What is associated with Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 3?",
    "seeds": [
      "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 3"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07919",
    "question": "What is associated with Ectodermal dysplasia 7, Hair/nail type?",
    "seeds": [
      "Ectodermal dysplasia 7, Hair/nail type"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07920",
    "question": "What is associated with Renal hamartoma?",
    "seeds": [
      "Renal hamartoma"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07921",
    "question": "What is associated with Abnormality of the epiphysis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Abnormality of the epiphysis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07922",
    "question": "What is associated with Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection?",
    "seeds": [
      "Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection"
    ],
    "gold_answer": "IFNAR2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_07923",
    "question": "What is associated with Cortical myoclonus?",
    "seeds": [
      "Cortical myoclonus"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07924",
    "question": "What phenotype is associated with Lymphedema-distichiasis syndrome?",
    "seeds": [
      "Lymphedema-distichiasis syndrome"
    ],
    "gold_answer": "Diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07925",
    "question": "What is associated with 1-minute APGAR score of 3?",
    "seeds": [
      "1-minute APGAR score of 3"
    ],
    "gold_answer": "Low APGAR score",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07926",
    "question": "What is associated with Maculopapular exanthema?",
    "seeds": [
      "Maculopapular exanthema"
    ],
    "gold_answer": "Exanthem",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07927",
    "question": "What is associated with Sick sinus syndrome 2?",
    "seeds": [
      "Sick sinus syndrome 2"
    ],
    "gold_answer": "Supraventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07928",
    "question": "What is associated with Pilomatrixoma?",
    "seeds": [
      "Pilomatrixoma"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07929",
    "question": "What is associated with Rhabdomyosarcoma 1?",
    "seeds": [
      "Rhabdomyosarcoma 1"
    ],
    "gold_answer": "NF1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07930",
    "question": "What is associated with Renal arteriole endoarterial hypercellularity?",
    "seeds": [
      "Renal arteriole endoarterial hypercellularity"
    ],
    "gold_answer": "Abnormal renal arteriole endothelium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07931",
    "question": "What is associated with Increased sialylated N-glycan level?",
    "seeds": [
      "Increased sialylated N-glycan level"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07932",
    "question": "What is associated with Solitary congenital hypertrophy of retinal pigment epithelium?",
    "seeds": [
      "Solitary congenital hypertrophy of retinal pigment epithelium"
    ],
    "gold_answer": "Congenital hypertrophy of retinal pigment epithelium",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07933",
    "question": "What is associated with Esophagitis, eosinophilic, 2?",
    "seeds": [
      "Esophagitis, eosinophilic, 2"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07934",
    "question": "What phenotype is associated with Cerebroretinal microangiopathy with calcifications and cysts 3?",
    "seeds": [
      "Cerebroretinal microangiopathy with calcifications and cysts 3"
    ],
    "gold_answer": "Gastrointestinal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07935",
    "question": "What is associated with Pontocerebellar hypoplasia, type 9?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 9"
    ],
    "gold_answer": "Slanting of the palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07936",
    "question": "What is associated with Hypoplasia of the iris?",
    "seeds": [
      "Hypoplasia of the iris"
    ],
    "gold_answer": "Abnormal uvea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07937",
    "question": "What is associated with Coronary cameral fistula?",
    "seeds": [
      "Coronary cameral fistula"
    ],
    "gold_answer": "Coronary artery fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07938",
    "question": "What phenotype is associated with Chronic inflammatory demyelinating polyneuropathy?",
    "seeds": [
      "Chronic inflammatory demyelinating polyneuropathy"
    ],
    "gold_answer": "Abnormal nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07939",
    "question": "What is associated with Retinal peau d'orange?",
    "seeds": [
      "Retinal peau d'orange"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07940",
    "question": "What is associated with Neuropathy, hereditary sensory, X-linked?",
    "seeds": [
      "Neuropathy, hereditary sensory, X-linked"
    ],
    "gold_answer": "Abnormal peripheral myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07941",
    "question": "What phenotype is associated with Spastic paraplegia 79A, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 79A, autosomal dominant"
    ],
    "gold_answer": "Dysarthria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07942",
    "question": "What is associated with Toe phalanx synostosis?",
    "seeds": [
      "Toe phalanx synostosis"
    ],
    "gold_answer": "Synostosis involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07943",
    "question": "What is associated with Abnormal transferrin saturation?",
    "seeds": [
      "Abnormal transferrin saturation"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07944",
    "question": "What is associated with Hypoplasia of deltoid muscle?",
    "seeds": [
      "Hypoplasia of deltoid muscle"
    ],
    "gold_answer": "Hypoplasia of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07945",
    "question": "What phenotype is associated with Lichen planus pemphigoides?",
    "seeds": [
      "Lichen planus pemphigoides"
    ],
    "gold_answer": "Blepharitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07946",
    "question": "What is associated with REN-related autosomal dominant tubulointerstitial kidney disease?",
    "seeds": [
      "REN-related autosomal dominant tubulointerstitial kidney disease"
    ],
    "gold_answer": "REN",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_07947",
    "question": "What is associated with Panner disease?",
    "seeds": [
      "Panner disease"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07948",
    "question": "What phenotype is associated with Adams-Oliver syndrome 4?",
    "seeds": [
      "Adams-Oliver syndrome 4"
    ],
    "gold_answer": "Patent ductus arteriosus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07949",
    "question": "What is associated with Iliac arterial calcification?",
    "seeds": [
      "Iliac arterial calcification"
    ],
    "gold_answer": "Lower extremity peripheral arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07950",
    "question": "What is associated with Hypoplasia of the capital femoral epiphysis?",
    "seeds": [
      "Hypoplasia of the capital femoral epiphysis"
    ],
    "gold_answer": "Abnormal femoral head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07951",
    "question": "What is associated with Atypical nevus?",
    "seeds": [
      "Atypical nevus"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07952",
    "question": "What is associated with EEG with photoparoxysmal response grade IV?",
    "seeds": [
      "EEG with photoparoxysmal response grade IV"
    ],
    "gold_answer": "EEG with photoparoxysmal response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07953",
    "question": "What is associated with Bone marrow failure syndrome 2?",
    "seeds": [
      "Bone marrow failure syndrome 2"
    ],
    "gold_answer": "Abnormal bone marrow cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07954",
    "question": "What is associated with Multiple central nervous system lipomas?",
    "seeds": [
      "Multiple central nervous system lipomas"
    ],
    "gold_answer": "Neoplasm of the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07955",
    "question": "What phenotype is associated with Toriello-Carey syndrome?",
    "seeds": [
      "Toriello-Carey syndrome"
    ],
    "gold_answer": "Hypoplastic left heart",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07956",
    "question": "What is associated with Multiple pulmonary cysts?",
    "seeds": [
      "Multiple pulmonary cysts"
    ],
    "gold_answer": "Pulmonary cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07957",
    "question": "What is associated with Decreased circulating alkaline phosphatase activity?",
    "seeds": [
      "Decreased circulating alkaline phosphatase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07958",
    "question": "What is associated with Sonographic renal salt and pepper pattern?",
    "seeds": [
      "Sonographic renal salt and pepper pattern"
    ],
    "gold_answer": "Abnormal renal echogenicity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07959",
    "question": "What is associated with Intolerance to protein?",
    "seeds": [
      "Intolerance to protein"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07960",
    "question": "What is associated with Beta-alaninuria?",
    "seeds": [
      "Beta-alaninuria"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07961",
    "question": "What is associated with Lissencephaly 2?",
    "seeds": [
      "Lissencephaly 2"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07962",
    "question": "What is associated with Glycosylphosphatidylinositol biosynthesis defect 16?",
    "seeds": [
      "Glycosylphosphatidylinositol biosynthesis defect 16"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07963",
    "question": "What phenotype is associated with Ring chromosome 13 syndrome?",
    "seeds": [
      "Ring chromosome 13 syndrome"
    ],
    "gold_answer": "Vitreous hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07964",
    "question": "What is associated with Erythrokeratodermia veriabilis et progressiva 6?",
    "seeds": [
      "Erythrokeratodermia veriabilis et progressiva 6"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07965",
    "question": "What is associated with Delayed early-childhood social milestone development?",
    "seeds": [
      "Delayed early-childhood social milestone development"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07966",
    "question": "What is associated with Pyruvate carboxylase deficiency?",
    "seeds": [
      "Pyruvate carboxylase deficiency"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07967",
    "question": "What is associated with Episodic?",
    "seeds": [
      "Episodic"
    ],
    "gold_answer": "Recurrent",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07968",
    "question": "What is associated with Elevated creatine kinase after exercise?",
    "seeds": [
      "Elevated creatine kinase after exercise"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07969",
    "question": "What is associated with Hypertelorism and other facial dysmorphism, brachydactyly, genital abnormalities, impaired intellectual development, and recurrent inflammatory episodes?",
    "seeds": [
      "Hypertelorism and other facial dysmorphism, brachydactyly, genital abnormalities, impaired intellectual development, and recurrent inflammatory episodes"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07970",
    "question": "What is associated with Secondary vesicoureteral reflux?",
    "seeds": [
      "Secondary vesicoureteral reflux"
    ],
    "gold_answer": "Vesicoureteral reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07971",
    "question": "What is associated with Spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07972",
    "question": "What is associated with Narrow nose?",
    "seeds": [
      "Narrow nose"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07973",
    "question": "What is associated with Absent nail of hallux?",
    "seeds": [
      "Absent nail of hallux"
    ],
    "gold_answer": "Anonychia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07974",
    "question": "What is associated with 17q24.2 microdeletion syndrome?",
    "seeds": [
      "17q24.2 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal affect regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07975",
    "question": "What is associated with Immunodeficiency 112?",
    "seeds": [
      "Immunodeficiency 112"
    ],
    "gold_answer": "IL17RC",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_07976",
    "question": "What is associated with Diminished MLH1 expression?",
    "seeds": [
      "Diminished MLH1 expression"
    ],
    "gold_answer": "Abnormal marker expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07977",
    "question": "What is associated with Hydrocephalus-obesity-hypogonadism syndrome?",
    "seeds": [
      "Hydrocephalus-obesity-hypogonadism syndrome"
    ],
    "gold_answer": "Short long bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07978",
    "question": "What is associated with Maldevelopment of radioulnar joint?",
    "seeds": [
      "Maldevelopment of radioulnar joint"
    ],
    "gold_answer": "Abnormality of the radioulnar joints",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07979",
    "question": "What is associated with Maternal anticardiolipin antibody positive?",
    "seeds": [
      "Maternal anticardiolipin antibody positive"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07980",
    "question": "What is associated with Pain in head and neck region?",
    "seeds": [
      "Pain in head and neck region"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07981",
    "question": "What phenotype is associated with Spastic paraplegia-nephritis-deafness syndrome?",
    "seeds": [
      "Spastic paraplegia-nephritis-deafness syndrome"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07982",
    "question": "What is associated with Bronchitis?",
    "seeds": [
      "Bronchitis"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07983",
    "question": "What is associated with Spinocerebellar ataxia type 20?",
    "seeds": [
      "Spinocerebellar ataxia type 20"
    ],
    "gold_answer": "Long-tract sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07984",
    "question": "What phenotype is associated with Pituitary dermoid and epidermoid cysts?",
    "seeds": [
      "Pituitary dermoid and epidermoid cysts"
    ],
    "gold_answer": "Meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_07985",
    "question": "What is associated with Bleeding disorder, platelet-type, 11?",
    "seeds": [
      "Bleeding disorder, platelet-type, 11"
    ],
    "gold_answer": "Impaired platelet aggregation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07986",
    "question": "What is associated with Frequent falls?",
    "seeds": [
      "Frequent falls"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07987",
    "question": "What is associated with Spinocerebellar degeneration and corneal dystrophy?",
    "seeds": [
      "Spinocerebellar degeneration and corneal dystrophy"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07988",
    "question": "What is associated with Reduced tissue carnitine O-palmitoyltransferase 2 activity?",
    "seeds": [
      "Reduced tissue carnitine O-palmitoyltransferase 2 activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07989",
    "question": "What is associated with Pressure-induced localized lipoatrophy?",
    "seeds": [
      "Pressure-induced localized lipoatrophy"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07990",
    "question": "What is associated with Dilatation of the renal pelvis?",
    "seeds": [
      "Dilatation of the renal pelvis"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07991",
    "question": "What is associated with Os trigonum?",
    "seeds": [
      "Os trigonum"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07992",
    "question": "What is associated with EEG with periodic complexes?",
    "seeds": [
      "EEG with periodic complexes"
    ],
    "gold_answer": "EEG with generalized polymorphic epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07993",
    "question": "What is associated with Vasculitis?",
    "seeds": [
      "Vasculitis"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07994",
    "question": "What is associated with Bleeding disorder, platelet-type, 13, susceptibility to?",
    "seeds": [
      "Bleeding disorder, platelet-type, 13, susceptibility to"
    ],
    "gold_answer": "Abnormal platelet aggregation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07995",
    "question": "What is associated with Osteosclerosis-ichthyosis-premature ovarian failure syndrome?",
    "seeds": [
      "Osteosclerosis-ichthyosis-premature ovarian failure syndrome"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07996",
    "question": "What is associated with Podocytic mitochondrial proliferation?",
    "seeds": [
      "Podocytic mitochondrial proliferation"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07997",
    "question": "What is associated with Benign chronic pemphigus?",
    "seeds": [
      "Benign chronic pemphigus"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07998",
    "question": "What is associated with Spurred ulnar metaphysis?",
    "seeds": [
      "Spurred ulnar metaphysis"
    ],
    "gold_answer": "Metaphyseal spurs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_07999",
    "question": "What is associated with Mandibular prognathia?",
    "seeds": [
      "Mandibular prognathia"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08000",
    "question": "What is associated with Split-Hand/foot malformation 1?",
    "seeds": [
      "Split-Hand/foot malformation 1"
    ],
    "gold_answer": "Aplasia/Hypoplasia of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08001",
    "question": "What is associated with Axillary epidermoid cyst?",
    "seeds": [
      "Axillary epidermoid cyst"
    ],
    "gold_answer": "Epidermoid cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08002",
    "question": "What is associated with Absent spinous processes of lower thoracic and lumbar vertebrae?",
    "seeds": [
      "Absent spinous processes of lower thoracic and lumbar vertebrae"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08003",
    "question": "What is associated with Neurodevelopmental disorder with seizures and brain abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with seizures and brain abnormalities"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08004",
    "question": "What is associated with Abnormal nervous system morphology?",
    "seeds": [
      "Abnormal nervous system morphology"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08005",
    "question": "What is associated with Familial renal glucosuria?",
    "seeds": [
      "Familial renal glucosuria"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08006",
    "question": "What phenotype is associated with Microtia-eye coloboma-imperforation of the nasolacrimal duct syndrome?",
    "seeds": [
      "Microtia-eye coloboma-imperforation of the nasolacrimal duct syndrome"
    ],
    "gold_answer": "Cryptorchidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08007",
    "question": "What is associated with Monoclonal elevation of circulating IgA?",
    "seeds": [
      "Monoclonal elevation of circulating IgA"
    ],
    "gold_answer": "Abnormal circulating IgA concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08008",
    "question": "What phenotype is associated with Deafness, congenital neurosensory, autosomal recessive 39?",
    "seeds": [
      "Deafness, congenital neurosensory, autosomal recessive 39"
    ],
    "gold_answer": "Prelingual sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08009",
    "question": "What is associated with Volvulus?",
    "seeds": [
      "Volvulus"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08010",
    "question": "What is associated with Tympanic membrane bulging?",
    "seeds": [
      "Tympanic membrane bulging"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08011",
    "question": "What is associated with Inverted CD4:CD8 ratio?",
    "seeds": [
      "Inverted CD4:CD8 ratio"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08012",
    "question": "What is associated with Pontocerebellar hypoplasia type 3?",
    "seeds": [
      "Pontocerebellar hypoplasia type 3"
    ],
    "gold_answer": "PCLO",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08013",
    "question": "What is associated with Dihydrolipoamide dehydrogenase deficiency?",
    "seeds": [
      "Dihydrolipoamide dehydrogenase deficiency"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08014",
    "question": "What is associated with Generalized?",
    "seeds": [
      "Generalized"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08015",
    "question": "What is associated with EPHB4-related lymphatic-related hydrops fetalis?",
    "seeds": [
      "EPHB4-related lymphatic-related hydrops fetalis"
    ],
    "gold_answer": "EPHB4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08016",
    "question": "What is associated with Steroid-sensitive nephrotic syndrome with frequent relapses?",
    "seeds": [
      "Steroid-sensitive nephrotic syndrome with frequent relapses"
    ],
    "gold_answer": "Steroid-sensitive nephrotic syndrome",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08017",
    "question": "What is associated with Tropical calcific pancreatitis?",
    "seeds": [
      "Tropical calcific pancreatitis"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08018",
    "question": "What is associated with Enterocutaneous fistula?",
    "seeds": [
      "Enterocutaneous fistula"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08019",
    "question": "What is associated with Non-motor seizure?",
    "seeds": [
      "Non-motor seizure"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08020",
    "question": "What is associated with Multiminicore myopathy?",
    "seeds": [
      "Multiminicore myopathy"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08021",
    "question": "What phenotype is associated with NPHP3-related Meckel-like syndrome?",
    "seeds": [
      "NPHP3-related Meckel-like syndrome"
    ],
    "gold_answer": "Oligohydramnios",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08022",
    "question": "What phenotype is associated with Short sleep, familial natural, 2?",
    "seeds": [
      "Short sleep, familial natural, 2"
    ],
    "gold_answer": "Shortened sleep phase",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08023",
    "question": "What is associated with Cyclophoria?",
    "seeds": [
      "Cyclophoria"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08024",
    "question": "What is associated with Cerebral hemorrhage?",
    "seeds": [
      "Cerebral hemorrhage"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08025",
    "question": "What is associated with Catecholaminergic polymorphic ventricular tachycardia?",
    "seeds": [
      "Catecholaminergic polymorphic ventricular tachycardia"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08026",
    "question": "What is associated with Jumping frenchman of maine?",
    "seeds": [
      "Jumping frenchman of maine"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08027",
    "question": "What is associated with Peroneus tertius muscle, absence of?",
    "seeds": [
      "Peroneus tertius muscle, absence of"
    ],
    "gold_answer": "Limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08028",
    "question": "What is associated with Decreased CD69 upregulation upon TCR activation?",
    "seeds": [
      "Decreased CD69 upregulation upon TCR activation"
    ],
    "gold_answer": "Abnormal T cell activation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08029",
    "question": "What is associated with Ureterocele?",
    "seeds": [
      "Ureterocele"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08030",
    "question": "What is associated with Hoyeraal-Hreidarsson syndrome?",
    "seeds": [
      "Hoyeraal-Hreidarsson syndrome"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08031",
    "question": "What is associated with Ophthalmic artery occlusion?",
    "seeds": [
      "Ophthalmic artery occlusion"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08032",
    "question": "What is associated with Spurred ulnar metaphysis?",
    "seeds": [
      "Spurred ulnar metaphysis"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08033",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 17?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 17"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08034",
    "question": "What is associated with Precocious puberty, central?",
    "seeds": [
      "Precocious puberty, central"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08035",
    "question": "What is associated with Deafness, X-linked 3?",
    "seeds": [
      "Deafness, X-linked 3"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08036",
    "question": "What is associated with Chin with vertical crease?",
    "seeds": [
      "Chin with vertical crease"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08037",
    "question": "What is associated with Obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay syndrome?",
    "seeds": [
      "Obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay syndrome"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08038",
    "question": "What is associated with Spastic paraplegia with associated extrapyramidal signs?",
    "seeds": [
      "Spastic paraplegia with associated extrapyramidal signs"
    ],
    "gold_answer": "Paraplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08039",
    "question": "What is associated with Mitochondrial DNA depletion syndrome 18?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 18"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08040",
    "question": "What is associated with Abnormal interpretation of external stimuli?",
    "seeds": [
      "Abnormal interpretation of external stimuli"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08041",
    "question": "What is associated with Renal-hepatic-pancreatic dysplasia 1?",
    "seeds": [
      "Renal-hepatic-pancreatic dysplasia 1"
    ],
    "gold_answer": "Abnormality of the hepatic vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08042",
    "question": "What is associated with Congenital disorder of glycosylation, type In?",
    "seeds": [
      "Congenital disorder of glycosylation, type In"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08043",
    "question": "What is associated with Deafness-vitiligo-achalasia syndrome?",
    "seeds": [
      "Deafness-vitiligo-achalasia syndrome"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08044",
    "question": "What phenotype is associated with Ohdo syndrome?",
    "seeds": [
      "Ohdo syndrome"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08045",
    "question": "What is associated with Soft skin?",
    "seeds": [
      "Soft skin"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08046",
    "question": "What phenotype is associated with Hemoglobin C-beta-thalassemia syndrome?",
    "seeds": [
      "Hemoglobin C-beta-thalassemia syndrome"
    ],
    "gold_answer": "Microcytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08047",
    "question": "What is associated with Abnormal limb epiphysis morphology?",
    "seeds": [
      "Abnormal limb epiphysis morphology"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08048",
    "question": "What is associated with Prolonged use of tightly fitting footwear?",
    "seeds": [
      "Prolonged use of tightly fitting footwear"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08049",
    "question": "What is associated with Nodular subcortical heterotopia in peritrigonal regions?",
    "seeds": [
      "Nodular subcortical heterotopia in peritrigonal regions"
    ],
    "gold_answer": "Subcortical heterotopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08050",
    "question": "What is associated with Abnormality of the hairline?",
    "seeds": [
      "Abnormality of the hairline"
    ],
    "gold_answer": "Abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08051",
    "question": "What is associated with Autism, susceptibility to, X-linked 6?",
    "seeds": [
      "Autism, susceptibility to, X-linked 6"
    ],
    "gold_answer": "Autistic behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08052",
    "question": "What is associated with Decreased circulating T4 concentration?",
    "seeds": [
      "Decreased circulating T4 concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08053",
    "question": "What is associated with Woolly hair nevus?",
    "seeds": [
      "Woolly hair nevus"
    ],
    "gold_answer": "Abnormal pupil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08054",
    "question": "What is associated with Microscopic polyangiitis?",
    "seeds": [
      "Microscopic polyangiitis"
    ],
    "gold_answer": "Abnormality of blood circulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08055",
    "question": "What is associated with Decreased CSF N-acetyl-aspartyl-glutamate concentration?",
    "seeds": [
      "Decreased CSF N-acetyl-aspartyl-glutamate concentration"
    ],
    "gold_answer": "Abnormal CSF protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08056",
    "question": "What is associated with Cerebellar calcifications?",
    "seeds": [
      "Cerebellar calcifications"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08057",
    "question": "What is associated with Anorectal abscess?",
    "seeds": [
      "Anorectal abscess"
    ],
    "gold_answer": "Abscess",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08058",
    "question": "What is associated with Saccadic oscillation?",
    "seeds": [
      "Saccadic oscillation"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08059",
    "question": "What is associated with Nodular melanoma?",
    "seeds": [
      "Nodular melanoma"
    ],
    "gold_answer": "Cutaneous melanoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08060",
    "question": "What is associated with Absence of intrinsic factor?",
    "seeds": [
      "Absence of intrinsic factor"
    ],
    "gold_answer": "Abnormal stomach morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08061",
    "question": "What is associated with Interstitial nephritis, karyomegalic?",
    "seeds": [
      "Interstitial nephritis, karyomegalic"
    ],
    "gold_answer": "Abnormal urine cytology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08062",
    "question": "What is associated with Focal hyperpigmented area associated with subretinal scar tissue?",
    "seeds": [
      "Focal hyperpigmented area associated with subretinal scar tissue"
    ],
    "gold_answer": "Abnormal fundus pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08063",
    "question": "What is associated with Folate-responsive megaloblastic anemia?",
    "seeds": [
      "Folate-responsive megaloblastic anemia"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08064",
    "question": "What is associated with Alazami syndrome?",
    "seeds": [
      "Alazami syndrome"
    ],
    "gold_answer": "Abnormality of mouth size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08065",
    "question": "What phenotype is associated with Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities?",
    "seeds": [
      "Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08066",
    "question": "What is associated with Medial arterial calcification?",
    "seeds": [
      "Medial arterial calcification"
    ],
    "gold_answer": "Arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08067",
    "question": "What is associated with Venous malformations, multiple cutaneous and mucosal?",
    "seeds": [
      "Venous malformations, multiple cutaneous and mucosal"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08068",
    "question": "What is associated with Glycogen accumulation in muscle fiber lysosomes?",
    "seeds": [
      "Glycogen accumulation in muscle fiber lysosomes"
    ],
    "gold_answer": "Abnormal muscle tissue metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08069",
    "question": "What is associated with Spermatogenic failure 66?",
    "seeds": [
      "Spermatogenic failure 66"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08070",
    "question": "What phenotype is associated with Circumvallate placenta syndrome?",
    "seeds": [
      "Circumvallate placenta syndrome"
    ],
    "gold_answer": "Intracranial hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08071",
    "question": "What is associated with Vitreous floaters?",
    "seeds": [
      "Vitreous floaters"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08072",
    "question": "What is associated with Platelet antibody positive?",
    "seeds": [
      "Platelet antibody positive"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08073",
    "question": "What is associated with Bicoronal synostosis?",
    "seeds": [
      "Bicoronal synostosis"
    ],
    "gold_answer": "Coronal craniosynostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08074",
    "question": "What is associated with Primary CD59 deficiency?",
    "seeds": [
      "Primary CD59 deficiency"
    ],
    "gold_answer": "CD59",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08075",
    "question": "What is associated with Membranous ventricular septal aneurysm?",
    "seeds": [
      "Membranous ventricular septal aneurysm"
    ],
    "gold_answer": "Abnormal cardiac septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08076",
    "question": "What is associated with Cylindruria?",
    "seeds": [
      "Cylindruria"
    ],
    "gold_answer": "Abnormal urine cytology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08077",
    "question": "What is associated with Spastic paraplegia 82, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 82, autosomal recessive"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08078",
    "question": "What phenotype is associated with DYSTELEPHALANGY?",
    "seeds": [
      "DYSTELEPHALANGY"
    ],
    "gold_answer": "Curved distal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08079",
    "question": "What phenotype is associated with Cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia?",
    "seeds": [
      "Cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia"
    ],
    "gold_answer": "Metaphyseal irregularity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08080",
    "question": "What phenotype is associated with Spastic ataxia 1, autosomal dominant?",
    "seeds": [
      "Spastic ataxia 1, autosomal dominant"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08081",
    "question": "What is associated with Gonadotropin deficiency?",
    "seeds": [
      "Gonadotropin deficiency"
    ],
    "gold_answer": "Anterior hypopituitarism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08082",
    "question": "What is associated with Developmental and epileptic encephalopathy 89?",
    "seeds": [
      "Developmental and epileptic encephalopathy 89"
    ],
    "gold_answer": "Micrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08083",
    "question": "What is associated with Mulberry molar?",
    "seeds": [
      "Mulberry molar"
    ],
    "gold_answer": "Supernumerary cusp",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08084",
    "question": "What is associated with Prenatal double bubble sign?",
    "seeds": [
      "Prenatal double bubble sign"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08085",
    "question": "What is associated with Regional left ventricular wall motion abnormality?",
    "seeds": [
      "Regional left ventricular wall motion abnormality"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08086",
    "question": "What is associated with Greig cephalopolysyndactyly syndrome?",
    "seeds": [
      "Greig cephalopolysyndactyly syndrome"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08087",
    "question": "What is associated with Autosomal dominant severe congenital neutropenia?",
    "seeds": [
      "Autosomal dominant severe congenital neutropenia"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08088",
    "question": "What is associated with Stippling of the epiphysis of the distal phalanx of the thumb?",
    "seeds": [
      "Stippling of the epiphysis of the distal phalanx of the thumb"
    ],
    "gold_answer": "Stippling of the epiphyses of the distal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08089",
    "question": "What is associated with Elevated circulating apolipoprotein A-IV concentration?",
    "seeds": [
      "Elevated circulating apolipoprotein A-IV concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08090",
    "question": "What is associated with Synophrys?",
    "seeds": [
      "Synophrys"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08091",
    "question": "What is associated with Short stature, optic nerve atrophy, and pelger-huet anomaly?",
    "seeds": [
      "Short stature, optic nerve atrophy, and pelger-huet anomaly"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08092",
    "question": "What is associated with Attention deficit-hyperactivity disorder?",
    "seeds": [
      "Attention deficit-hyperactivity disorder"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08093",
    "question": "What phenotype is associated with Bilateral parasagittal parieto-occipital polymicrogyria?",
    "seeds": [
      "Bilateral parasagittal parieto-occipital polymicrogyria"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08094",
    "question": "What is associated with Luo-Schoch-Yamamoto syndrome?",
    "seeds": [
      "Luo-Schoch-Yamamoto syndrome"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08095",
    "question": "What is associated with Myocardial fibrosis?",
    "seeds": [
      "Myocardial fibrosis"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08096",
    "question": "What is associated with Cochlear nerve aplasia?",
    "seeds": [
      "Cochlear nerve aplasia"
    ],
    "gold_answer": "Abnormal inner ear nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08097",
    "question": "What phenotype is associated with Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2?",
    "seeds": [
      "Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2"
    ],
    "gold_answer": "Exocrine pancreatic insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08098",
    "question": "What phenotype is associated with Absent radius-anogenital anomalies syndrome?",
    "seeds": [
      "Absent radius-anogenital anomalies syndrome"
    ],
    "gold_answer": "Ectrodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08099",
    "question": "What is associated with 1-minute APGAR score of 4?",
    "seeds": [
      "1-minute APGAR score of 4"
    ],
    "gold_answer": "Low APGAR score",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08100",
    "question": "What is associated with Diarrhea?",
    "seeds": [
      "Diarrhea"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08101",
    "question": "What is associated with Oocyte maturation defect 12?",
    "seeds": [
      "Oocyte maturation defect 12"
    ],
    "gold_answer": "Abnormal embryonic development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08102",
    "question": "What is associated with Unfavorable response of muscle weakness to acetylcholine esterase inhibitors?",
    "seeds": [
      "Unfavorable response of muscle weakness to acetylcholine esterase inhibitors"
    ],
    "gold_answer": "Response to drugs acting on neuromuscular transmission",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08103",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 73?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 73"
    ],
    "gold_answer": "Hypoglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08104",
    "question": "What is associated with Congenital disorder of glycosylation, type IIr?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIr"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08105",
    "question": "What is associated with Progressive vitiligo?",
    "seeds": [
      "Progressive vitiligo"
    ],
    "gold_answer": "Vitiligo",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08106",
    "question": "What phenotype is associated with Hemochromatosis, type 2B?",
    "seeds": [
      "Hemochromatosis, type 2B"
    ],
    "gold_answer": "Congestive heart failure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08107",
    "question": "What is associated with Meconium aspiration syndrome?",
    "seeds": [
      "Meconium aspiration syndrome"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08108",
    "question": "What phenotype is associated with EPICANTHUS?",
    "seeds": [
      "EPICANTHUS"
    ],
    "gold_answer": "Epicanthus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08109",
    "question": "What phenotype is associated with Hypodontia-dysplasia of nails syndrome?",
    "seeds": [
      "Hypodontia-dysplasia of nails syndrome"
    ],
    "gold_answer": "Polycystic ovaries",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08110",
    "question": "What phenotype is associated with Leg, absence deformity of, with congenital cataract?",
    "seeds": [
      "Leg, absence deformity of, with congenital cataract"
    ],
    "gold_answer": "Developmental cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08111",
    "question": "What is associated with Subependymal giant-cell astrocytoma?",
    "seeds": [
      "Subependymal giant-cell astrocytoma"
    ],
    "gold_answer": "Abnormal glial cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08112",
    "question": "What is associated with KLHL7-related Bohring-Opitz-like and Crisponi/Cold-induced sweating-like overlap syndrome?",
    "seeds": [
      "KLHL7-related Bohring-Opitz-like and Crisponi/Cold-induced sweating-like overlap syndrome"
    ],
    "gold_answer": "KLHL7",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08113",
    "question": "What is associated with Tibiotalar synostosis?",
    "seeds": [
      "Tibiotalar synostosis"
    ],
    "gold_answer": "Synostosis involving the fibula",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08114",
    "question": "What is associated with Cataract-hypertrichosis-intellectual disability syndrome?",
    "seeds": [
      "Cataract-hypertrichosis-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08115",
    "question": "What is associated with Craniofacial asymmetry?",
    "seeds": [
      "Craniofacial asymmetry"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08116",
    "question": "What is associated with Hypernatriuria?",
    "seeds": [
      "Hypernatriuria"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08117",
    "question": "What is associated with Malrotation of colon?",
    "seeds": [
      "Malrotation of colon"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08118",
    "question": "What is associated with Focal impaired awareness manual automatism seizure?",
    "seeds": [
      "Focal impaired awareness manual automatism seizure"
    ],
    "gold_answer": "Focal automatism seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08119",
    "question": "What is associated with Unusual gastrointestinal infection?",
    "seeds": [
      "Unusual gastrointestinal infection"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08120",
    "question": "What phenotype is associated with Myoclonic epilepsy, juvenile, 2?",
    "seeds": [
      "Myoclonic epilepsy, juvenile, 2"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08121",
    "question": "What phenotype is associated with AICA-ribosiduria?",
    "seeds": [
      "AICA-ribosiduria"
    ],
    "gold_answer": "Low-set ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08122",
    "question": "What is associated with Anti-factor VII antibody positivity?",
    "seeds": [
      "Anti-factor VII antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08123",
    "question": "What is associated with Indifference to pain, congenital, autosomal recessive?",
    "seeds": [
      "Indifference to pain, congenital, autosomal recessive"
    ],
    "gold_answer": "Abnormality of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08124",
    "question": "What is associated with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency?",
    "seeds": [
      "3-hydroxy-3-methylglutaryl-CoA lyase deficiency"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08125",
    "question": "What is associated with Reduced beta-hexosaminidase B activity?",
    "seeds": [
      "Reduced beta-hexosaminidase B activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08126",
    "question": "What is associated with Scoliosis?",
    "seeds": [
      "Scoliosis"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08127",
    "question": "What is associated with Continuous heart murmur?",
    "seeds": [
      "Continuous heart murmur"
    ],
    "gold_answer": "Abnormal heart sound",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08128",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanx of the hallux?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanx of the hallux"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08129",
    "question": "What is associated with Symmetric great toe depigmentation?",
    "seeds": [
      "Symmetric great toe depigmentation"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08130",
    "question": "What phenotype is associated with Chromosome 14q11-q22 deletion syndrome?",
    "seeds": [
      "Chromosome 14q11-q22 deletion syndrome"
    ],
    "gold_answer": "Barrett esophagus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08131",
    "question": "What is associated with Thyroid atypical adenoma?",
    "seeds": [
      "Thyroid atypical adenoma"
    ],
    "gold_answer": "Neoplasm of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08132",
    "question": "What is associated with Short 4th metacarpal?",
    "seeds": [
      "Short 4th metacarpal"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the metacarpal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08133",
    "question": "What is associated with Part-solid pulmonary nodule?",
    "seeds": [
      "Part-solid pulmonary nodule"
    ],
    "gold_answer": "Abnormal pulmonary thoracic imaging finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08134",
    "question": "What phenotype is associated with Familial congenital mirror movements?",
    "seeds": [
      "Familial congenital mirror movements"
    ],
    "gold_answer": "Poor fine motor coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08135",
    "question": "What is associated with Alpha-B crystallin-related late-onset myopathy?",
    "seeds": [
      "Alpha-B crystallin-related late-onset myopathy"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08136",
    "question": "What is associated with Sudden cardiac failure, alcohol-induced?",
    "seeds": [
      "Sudden cardiac failure, alcohol-induced"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08137",
    "question": "What is associated with Delayed tarsal ossification?",
    "seeds": [
      "Delayed tarsal ossification"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08138",
    "question": "What is associated with Decreased circulating complement component 1s concentration?",
    "seeds": [
      "Decreased circulating complement component 1s concentration"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08139",
    "question": "What is associated with Intratubular hemoglobin casts?",
    "seeds": [
      "Intratubular hemoglobin casts"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08140",
    "question": "What is associated with Abnormal conjugate eye movement?",
    "seeds": [
      "Abnormal conjugate eye movement"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08141",
    "question": "What is associated with Bilateral cryptorchidism?",
    "seeds": [
      "Bilateral cryptorchidism"
    ],
    "gold_answer": "Cryptorchidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08142",
    "question": "What is associated with Cerebellar atrophy?",
    "seeds": [
      "Cerebellar atrophy"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08143",
    "question": "What is associated with Myoclonus-cerebellar ataxia-deafness syndrome?",
    "seeds": [
      "Myoclonus-cerebellar ataxia-deafness syndrome"
    ],
    "gold_answer": "EMG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08144",
    "question": "What phenotype is associated with Congenital pulmonary lymphangiectasia?",
    "seeds": [
      "Congenital pulmonary lymphangiectasia"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08145",
    "question": "What is associated with Abnormality of inferior oblique extraocular muscle?",
    "seeds": [
      "Abnormality of inferior oblique extraocular muscle"
    ],
    "gold_answer": "Abnormality of the extraocular muscles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08146",
    "question": "What is associated with Elevated urinary N-tau-ribosylhistidine level?",
    "seeds": [
      "Elevated urinary N-tau-ribosylhistidine level"
    ],
    "gold_answer": "Increased urine proteinogenic amino acid derivative level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08147",
    "question": "What is associated with Quadriceps aplasia?",
    "seeds": [
      "Quadriceps aplasia"
    ],
    "gold_answer": "Abnormality of muscle size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08148",
    "question": "What is associated with Abnormality of the middle ear ossicles?",
    "seeds": [
      "Abnormality of the middle ear ossicles"
    ],
    "gold_answer": "Abnormal middle ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08149",
    "question": "What is associated with Focal aware cognitive seizure with expressive dysphasia/aphasia?",
    "seeds": [
      "Focal aware cognitive seizure with expressive dysphasia/aphasia"
    ],
    "gold_answer": "Focal aware non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08150",
    "question": "What is associated with Plantar telangiectasia?",
    "seeds": [
      "Plantar telangiectasia"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08151",
    "question": "What is associated with Primary condylar hyperplasia?",
    "seeds": [
      "Primary condylar hyperplasia"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08152",
    "question": "What is associated with Elevated urine 2-methylacetoacetic acid level?",
    "seeds": [
      "Elevated urine 2-methylacetoacetic acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08153",
    "question": "What is associated with Increased proportion of CD8+ TEMRA T cells?",
    "seeds": [
      "Increased proportion of CD8+ TEMRA T cells"
    ],
    "gold_answer": "Abnormal memory CD8+ T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08154",
    "question": "What is associated with Gombo syndrome?",
    "seeds": [
      "Gombo syndrome"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08155",
    "question": "What is associated with Elevated circulating hyaluronic acid concentration?",
    "seeds": [
      "Elevated circulating hyaluronic acid concentration"
    ],
    "gold_answer": "Abnormal circulating polysaccharide concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08156",
    "question": "What is associated with Hemoglobin Barts?",
    "seeds": [
      "Hemoglobin Barts"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08157",
    "question": "What phenotype is associated with Chromosome 15q11.2 deletion syndrome?",
    "seeds": [
      "Chromosome 15q11.2 deletion syndrome"
    ],
    "gold_answer": "Elevated circulating C-reactive protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08158",
    "question": "What is associated with Subcutaneous ossification?",
    "seeds": [
      "Subcutaneous ossification"
    ],
    "gold_answer": "Ectopic ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08159",
    "question": "What is associated with Developmental dysplasia of the hip 3?",
    "seeds": [
      "Developmental dysplasia of the hip 3"
    ],
    "gold_answer": "Abnormal hip joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08160",
    "question": "What is associated with Acute otitis media?",
    "seeds": [
      "Acute otitis media"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08161",
    "question": "What is associated with Bronchial neoplasm?",
    "seeds": [
      "Bronchial neoplasm"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08162",
    "question": "What is associated with Niemann-Pick disease type C, severe perinatal form?",
    "seeds": [
      "Niemann-Pick disease type C, severe perinatal form"
    ],
    "gold_answer": "NPC2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08163",
    "question": "What is associated with Urethral fistula?",
    "seeds": [
      "Urethral fistula"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08164",
    "question": "What is associated with Beta-thalassemia intermedia?",
    "seeds": [
      "Beta-thalassemia intermedia"
    ],
    "gold_answer": "Pre-capillary pulmonary hypertension",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08165",
    "question": "What is associated with Chronic bronchitis?",
    "seeds": [
      "Chronic bronchitis"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08166",
    "question": "What is associated with Polydactyly, postaxial, type A7?",
    "seeds": [
      "Polydactyly, postaxial, type A7"
    ],
    "gold_answer": "Abnormal fifth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08167",
    "question": "What is associated with Hypoplasia of the epiglottis?",
    "seeds": [
      "Hypoplasia of the epiglottis"
    ],
    "gold_answer": "Abnormal epiglottis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08168",
    "question": "What is associated with Stippled calcification of hand bones?",
    "seeds": [
      "Stippled calcification of hand bones"
    ],
    "gold_answer": "Irregular ossification of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08169",
    "question": "What phenotype is associated with Torticollis, keloids, cryptorchidism, and renal dysplasia?",
    "seeds": [
      "Torticollis, keloids, cryptorchidism, and renal dysplasia"
    ],
    "gold_answer": "Unilateral renal atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08170",
    "question": "What is associated with Eosinophilic lymph node infiltration?",
    "seeds": [
      "Eosinophilic lymph node infiltration"
    ],
    "gold_answer": "Abnormal lymph node cell composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08171",
    "question": "What is associated with Abnormal subungual morphology?",
    "seeds": [
      "Abnormal subungual morphology"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08172",
    "question": "What is associated with Fragmented finger phalanx epiphysis?",
    "seeds": [
      "Fragmented finger phalanx epiphysis"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08173",
    "question": "What is associated with Autosomal recessive bestrophinopathy?",
    "seeds": [
      "Autosomal recessive bestrophinopathy"
    ],
    "gold_answer": "BEST1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08174",
    "question": "What is associated with Cerebral calcification?",
    "seeds": [
      "Cerebral calcification"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08175",
    "question": "What is associated with 46,XX difference of sex development-skeletal anomalies syndrome?",
    "seeds": [
      "46,XX difference of sex development-skeletal anomalies syndrome"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08176",
    "question": "What is associated with Olivopontocerebellar atrophy?",
    "seeds": [
      "Olivopontocerebellar atrophy"
    ],
    "gold_answer": "Abnormal hindbrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08177",
    "question": "What is associated with Emphysema, congenital lobar?",
    "seeds": [
      "Emphysema, congenital lobar"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08178",
    "question": "What is associated with 9q33.3q34.11 microdeletion syndrome?",
    "seeds": [
      "9q33.3q34.11 microdeletion syndrome"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08179",
    "question": "What is associated with Neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities, autosomal dominant?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities, autosomal dominant"
    ],
    "gold_answer": "Bilateral tonic-clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08180",
    "question": "What is associated with Familial porphyria cutanea tarda?",
    "seeds": [
      "Familial porphyria cutanea tarda"
    ],
    "gold_answer": "UROD",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_08181",
    "question": "What is associated with Delayed ability to roll over?",
    "seeds": [
      "Delayed ability to roll over"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08182",
    "question": "What phenotype is associated with Epidermolysis bullosa simplex, Dowling-Meara type?",
    "seeds": [
      "Epidermolysis bullosa simplex, Dowling-Meara type"
    ],
    "gold_answer": "Milia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08183",
    "question": "What is associated with Increased RBC distribution width?",
    "seeds": [
      "Increased RBC distribution width"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08184",
    "question": "What is associated with Small epiphyses of the 2nd finger?",
    "seeds": [
      "Small epiphyses of the 2nd finger"
    ],
    "gold_answer": "Small epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08185",
    "question": "What is associated with Maturity-onset diabetes of the young, type 13?",
    "seeds": [
      "Maturity-onset diabetes of the young, type 13"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08186",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Patchy sclerosis of 2nd finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08187",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 38?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 38"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08188",
    "question": "What is associated with Renal interstitial xanthogranulomatous inflammation?",
    "seeds": [
      "Renal interstitial xanthogranulomatous inflammation"
    ],
    "gold_answer": "Abnormal renal interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08189",
    "question": "What phenotype is associated with Skraban-Deardorff syndrome?",
    "seeds": [
      "Skraban-Deardorff syndrome"
    ],
    "gold_answer": "Small hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08190",
    "question": "What is associated with Reduced Acyl-CoA:dihydroxyacetone phosphate acyltransferase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced Acyl-CoA:dihydroxyacetone phosphate acyltransferase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal enzyme activity in cultured fibroblasts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08191",
    "question": "What is associated with Focal aware motor seizure with dysarthria/anarthria?",
    "seeds": [
      "Focal aware motor seizure with dysarthria/anarthria"
    ],
    "gold_answer": "Focal aware motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08192",
    "question": "What phenotype is associated with Renpenning syndrome?",
    "seeds": [
      "Renpenning syndrome"
    ],
    "gold_answer": "Narrow foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08193",
    "question": "What phenotype is associated with Chromosome 20q11-q12 deletion syndrome?",
    "seeds": [
      "Chromosome 20q11-q12 deletion syndrome"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08194",
    "question": "What is associated with Fusiform cerebral aneurysm?",
    "seeds": [
      "Fusiform cerebral aneurysm"
    ],
    "gold_answer": "Abnormal cerebral artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08195",
    "question": "What is associated with Abnormal aortic valve cusp morphology?",
    "seeds": [
      "Abnormal aortic valve cusp morphology"
    ],
    "gold_answer": "Abnormal aortic valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08196",
    "question": "What is associated with Fractured fibula?",
    "seeds": [
      "Fractured fibula"
    ],
    "gold_answer": "Fractured hindlimb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08197",
    "question": "What is associated with Aniridia 2?",
    "seeds": [
      "Aniridia 2"
    ],
    "gold_answer": "Abnormal optic disc morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08198",
    "question": "What is associated with Malar prominence?",
    "seeds": [
      "Malar prominence"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08199",
    "question": "What is associated with Reduced haptoglobin level?",
    "seeds": [
      "Reduced haptoglobin level"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08200",
    "question": "What is associated with PR segment depression?",
    "seeds": [
      "PR segment depression"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08201",
    "question": "What is associated with Positive blood lead test?",
    "seeds": [
      "Positive blood lead test"
    ],
    "gold_answer": "Blood xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08202",
    "question": "What is associated with Multiple rib fractures?",
    "seeds": [
      "Multiple rib fractures"
    ],
    "gold_answer": "Abnormal rib morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08203",
    "question": "What is associated with Square-wave jerks?",
    "seeds": [
      "Square-wave jerks"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08204",
    "question": "What is associated with Unilateral renal atrophy?",
    "seeds": [
      "Unilateral renal atrophy"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08205",
    "question": "What is associated with Abnormal palate morphology?",
    "seeds": [
      "Abnormal palate morphology"
    ],
    "gold_answer": "Abnormality of the mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08206",
    "question": "What phenotype is associated with Lacrimoauriculodentodigital syndrome-2?",
    "seeds": [
      "Lacrimoauriculodentodigital syndrome-2"
    ],
    "gold_answer": "Deeply set eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08207",
    "question": "What is associated with Cortical sclerosis?",
    "seeds": [
      "Cortical sclerosis"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08208",
    "question": "What is associated with Aortic arch anomaly-facial dysmorphism-intellectual disability syndrome?",
    "seeds": [
      "Aortic arch anomaly-facial dysmorphism-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08209",
    "question": "What phenotype is associated with Cerebellar hypoplasia-tapetoretinal degeneration syndrome?",
    "seeds": [
      "Cerebellar hypoplasia-tapetoretinal degeneration syndrome"
    ],
    "gold_answer": "Abnormal electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08210",
    "question": "What phenotype is associated with Doyne honeycomb retinal dystrophy?",
    "seeds": [
      "Doyne honeycomb retinal dystrophy"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08211",
    "question": "What is associated with Osteosclerosis of the ulna?",
    "seeds": [
      "Osteosclerosis of the ulna"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08212",
    "question": "What is associated with Ectodermal dysplasia 14, hair/tooth type with or without hypohidrosis?",
    "seeds": [
      "Ectodermal dysplasia 14, hair/tooth type with or without hypohidrosis"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08213",
    "question": "What is associated with Triangular epiphysis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Triangular epiphysis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08214",
    "question": "What is associated with Menke-Hennekam syndrome 1?",
    "seeds": [
      "Menke-Hennekam syndrome 1"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08215",
    "question": "What is associated with Amelogenesis imperfecta, hypomaturation type, iia3?",
    "seeds": [
      "Amelogenesis imperfecta, hypomaturation type, iia3"
    ],
    "gold_answer": "Abnormal oral physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08216",
    "question": "What is associated with Bleeding disorder in hemophilia A carriers?",
    "seeds": [
      "Bleeding disorder in hemophilia A carriers"
    ],
    "gold_answer": "Abnormality of the menstrual cycle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08217",
    "question": "What is associated with Abnormal coronary artery course?",
    "seeds": [
      "Abnormal coronary artery course"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08218",
    "question": "What phenotype is associated with Zttk syndrome?",
    "seeds": [
      "Zttk syndrome"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08219",
    "question": "What is associated with Impaired ability to organize?",
    "seeds": [
      "Impaired ability to organize"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08220",
    "question": "What is associated with Neurodevelopmental disorder with hyperkinetic movements and dyskinesia?",
    "seeds": [
      "Neurodevelopmental disorder with hyperkinetic movements and dyskinesia"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08221",
    "question": "What is associated with Synostosis involving the 1st metatarsal?",
    "seeds": [
      "Synostosis involving the 1st metatarsal"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08222",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 7?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 7"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08223",
    "question": "What is associated with Cerebral berry aneurysm?",
    "seeds": [
      "Cerebral berry aneurysm"
    ],
    "gold_answer": "Abnormal cerebral artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08224",
    "question": "What is associated with Ectopic accessory toe-like appendage?",
    "seeds": [
      "Ectopic accessory toe-like appendage"
    ],
    "gold_answer": "Foot polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08225",
    "question": "What is associated with Urachal diverticulum?",
    "seeds": [
      "Urachal diverticulum"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08226",
    "question": "What is associated with Supernumerary lacrimal punctum?",
    "seeds": [
      "Supernumerary lacrimal punctum"
    ],
    "gold_answer": "Abnormal lacrimal punctum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08227",
    "question": "What is associated with Bidirectional ventricular ectopy?",
    "seeds": [
      "Bidirectional ventricular ectopy"
    ],
    "gold_answer": "Premature ventricular contraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08228",
    "question": "What is associated with Poliosis?",
    "seeds": [
      "Poliosis"
    ],
    "gold_answer": "Abnormality of hair pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08229",
    "question": "What is associated with Ciliary dyskinesia, primary, 19?",
    "seeds": [
      "Ciliary dyskinesia, primary, 19"
    ],
    "gold_answer": "Decreased fertility in males",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08230",
    "question": "What is associated with Lymphatic malformation 1?",
    "seeds": [
      "Lymphatic malformation 1"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08231",
    "question": "What is associated with Cone-Rod dystrophy 2?",
    "seeds": [
      "Cone-Rod dystrophy 2"
    ],
    "gold_answer": "Retinal atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08232",
    "question": "What is associated with Anti-Ma1 antibody positivity?",
    "seeds": [
      "Anti-Ma1 antibody positivity"
    ],
    "gold_answer": "Anti-Ma antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08233",
    "question": "What is associated with Oocyte maturation defect 11?",
    "seeds": [
      "Oocyte maturation defect 11"
    ],
    "gold_answer": "Infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08234",
    "question": "What is associated with Absent epiphyses of the 2nd finger?",
    "seeds": [
      "Absent epiphyses of the 2nd finger"
    ],
    "gold_answer": "Absent epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08235",
    "question": "What phenotype is associated with Transketolase deficiency?",
    "seeds": [
      "Transketolase deficiency"
    ],
    "gold_answer": "Type I diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08236",
    "question": "What is associated with Weiss-Kruszka syndrome?",
    "seeds": [
      "Weiss-Kruszka syndrome"
    ],
    "gold_answer": "Abnormality of the metopic suture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08237",
    "question": "What is associated with Vaginal foreign body sensation?",
    "seeds": [
      "Vaginal foreign body sensation"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08238",
    "question": "What is associated with Nephropathy, progressive tubulointerstitial, with cholestatic liverdisease?",
    "seeds": [
      "Nephropathy, progressive tubulointerstitial, with cholestatic liverdisease"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08239",
    "question": "What is associated with Abnormality of intracranial pressure?",
    "seeds": [
      "Abnormality of intracranial pressure"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08240",
    "question": "What is associated with Fibroadenoma of the breast?",
    "seeds": [
      "Fibroadenoma of the breast"
    ],
    "gold_answer": "Sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08241",
    "question": "What is associated with Platelet antibody positive?",
    "seeds": [
      "Platelet antibody positive"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08242",
    "question": "What is associated with Dystonia 22, adult-onset?",
    "seeds": [
      "Dystonia 22, adult-onset"
    ],
    "gold_answer": "Tremor by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08243",
    "question": "What is associated with Vestibulocochlear dysfunction, progressive?",
    "seeds": [
      "Vestibulocochlear dysfunction, progressive"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08244",
    "question": "What is associated with Sickle cell-beta plus-thalassemia?",
    "seeds": [
      "Sickle cell-beta plus-thalassemia"
    ],
    "gold_answer": "HBB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08245",
    "question": "What is associated with Breath-holding spell?",
    "seeds": [
      "Breath-holding spell"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08246",
    "question": "What is associated with Tetraamelia?",
    "seeds": [
      "Tetraamelia"
    ],
    "gold_answer": "Aplasia/hypoplasia of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08247",
    "question": "What is associated with Absent lower eyelashes?",
    "seeds": [
      "Absent lower eyelashes"
    ],
    "gold_answer": "Absent hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08248",
    "question": "What is associated with Priapism?",
    "seeds": [
      "Priapism"
    ],
    "gold_answer": "Male sexual dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08249",
    "question": "What is associated with Increased total neutrophil count?",
    "seeds": [
      "Increased total neutrophil count"
    ],
    "gold_answer": "Abnormal neutrophil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08250",
    "question": "What is associated with Developmental and epileptic encephalopathy with spike-wave activation in sleep?",
    "seeds": [
      "Developmental and epileptic encephalopathy with spike-wave activation in sleep"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08251",
    "question": "What phenotype is associated with Alpha-B crystallin-related late-onset myopathy?",
    "seeds": [
      "Alpha-B crystallin-related late-onset myopathy"
    ],
    "gold_answer": "Dysphonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08252",
    "question": "What is associated with Gonadal dysgenesis, male?",
    "seeds": [
      "Gonadal dysgenesis, male"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08253",
    "question": "What is associated with Giant cell hepatitis?",
    "seeds": [
      "Giant cell hepatitis"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08254",
    "question": "What is associated with Increased cardiac output?",
    "seeds": [
      "Increased cardiac output"
    ],
    "gold_answer": "Abnormal cardiac output",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08255",
    "question": "What is associated with Decreased RV/TLC ratio?",
    "seeds": [
      "Decreased RV/TLC ratio"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08256",
    "question": "What is associated with Eyelid fasciculation?",
    "seeds": [
      "Eyelid fasciculation"
    ],
    "gold_answer": "Abnormal eyelid movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08257",
    "question": "What is associated with Lymph node xanthomatosis?",
    "seeds": [
      "Lymph node xanthomatosis"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08258",
    "question": "What phenotype is associated with Isolated hemihyperplasia?",
    "seeds": [
      "Isolated hemihyperplasia"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08259",
    "question": "What is associated with Abnormal mitochondrial number?",
    "seeds": [
      "Abnormal mitochondrial number"
    ],
    "gold_answer": "Abnormal mitochondrial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08260",
    "question": "What is associated with Elevated circulating interleukin 1 receptor antagonist concentration?",
    "seeds": [
      "Elevated circulating interleukin 1 receptor antagonist concentration"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08261",
    "question": "What is associated with Asymmetry of the position of the ears?",
    "seeds": [
      "Asymmetry of the position of the ears"
    ],
    "gold_answer": "Asymmetry of the ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08262",
    "question": "What is associated with Elevated urine suberylglycine level?",
    "seeds": [
      "Elevated urine suberylglycine level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08263",
    "question": "What is associated with Ichthyosis vulgaris?",
    "seeds": [
      "Ichthyosis vulgaris"
    ],
    "gold_answer": "Abnormal epidermis stratum granulosum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08264",
    "question": "What phenotype is associated with Monosomy 9q22.3 syndrome?",
    "seeds": [
      "Monosomy 9q22.3 syndrome"
    ],
    "gold_answer": "Delayed eruption of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08265",
    "question": "What is associated with Increased circulating metamyelocyte count?",
    "seeds": [
      "Increased circulating metamyelocyte count"
    ],
    "gold_answer": "Increased circulating immature neutrophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08266",
    "question": "What phenotype is associated with Osteoarthritis with mild chondrodysplasia?",
    "seeds": [
      "Osteoarthritis with mild chondrodysplasia"
    ],
    "gold_answer": "Joint stiffness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08267",
    "question": "What is associated with Immunodeficiency 14?",
    "seeds": [
      "Immunodeficiency 14"
    ],
    "gold_answer": "Abnormal transitional B cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08268",
    "question": "What is associated with Black pigment gallstones?",
    "seeds": [
      "Black pigment gallstones"
    ],
    "gold_answer": "Pigment gallstones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08269",
    "question": "What is associated with Abnormality of superoxide metabolism?",
    "seeds": [
      "Abnormality of superoxide metabolism"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08270",
    "question": "What is associated with Ataxia-Oculomotor apraxia 3?",
    "seeds": [
      "Ataxia-Oculomotor apraxia 3"
    ],
    "gold_answer": "Peripheral axonal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08271",
    "question": "What is associated with CSF anti-myelin oligodendrocyte glycoprotein antibody positivity?",
    "seeds": [
      "CSF anti-myelin oligodendrocyte glycoprotein antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08272",
    "question": "What phenotype is associated with Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis?",
    "seeds": [
      "Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis"
    ],
    "gold_answer": "Knee flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08273",
    "question": "What is associated with Bifid first metacarpal?",
    "seeds": [
      "Bifid first metacarpal"
    ],
    "gold_answer": "Duplication of the 1st metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08274",
    "question": "What is associated with Abnormal muscle physiology?",
    "seeds": [
      "Abnormal muscle physiology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08275",
    "question": "What is associated with Colonic eosinophilia?",
    "seeds": [
      "Colonic eosinophilia"
    ],
    "gold_answer": "Inflammation of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08276",
    "question": "What is associated with Diabetes mellitus, transient neonatal, 1?",
    "seeds": [
      "Diabetes mellitus, transient neonatal, 1"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08277",
    "question": "What is associated with Type I truncus arteriosus?",
    "seeds": [
      "Type I truncus arteriosus"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08278",
    "question": "What is associated with Abnormal endocrine physiology?",
    "seeds": [
      "Abnormal endocrine physiology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08279",
    "question": "What is associated with Cone-shaped epiphyses of the phalanges of the hand?",
    "seeds": [
      "Cone-shaped epiphyses of the phalanges of the hand"
    ],
    "gold_answer": "Abnormal hand epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08280",
    "question": "What is associated with Secondary non-traumatic avascular necrosis?",
    "seeds": [
      "Secondary non-traumatic avascular necrosis"
    ],
    "gold_answer": "TNIP1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_08281",
    "question": "What is associated with Eggshell calcification of lymph nodes?",
    "seeds": [
      "Eggshell calcification of lymph nodes"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08282",
    "question": "What is associated with Hyperbilirubinemia, familial transient neonatal?",
    "seeds": [
      "Hyperbilirubinemia, familial transient neonatal"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08283",
    "question": "What is associated with Peripheral schwannoma?",
    "seeds": [
      "Peripheral schwannoma"
    ],
    "gold_answer": "Schwannoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08284",
    "question": "What is associated with Transillumination test shows high light transmission?",
    "seeds": [
      "Transillumination test shows high light transmission"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08285",
    "question": "What is associated with Pretibial blistering?",
    "seeds": [
      "Pretibial blistering"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08286",
    "question": "What is associated with Abnormality of the hypothenar eminence?",
    "seeds": [
      "Abnormality of the hypothenar eminence"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08287",
    "question": "What phenotype is associated with Opticocochleodentate degeneration?",
    "seeds": [
      "Opticocochleodentate degeneration"
    ],
    "gold_answer": "Visual loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08288",
    "question": "What is associated with Carey-Fineman-Ziter syndrome 2?",
    "seeds": [
      "Carey-Fineman-Ziter syndrome 2"
    ],
    "gold_answer": "Narrow palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08289",
    "question": "What is associated with Thyrotoxicosis with diffuse goiter?",
    "seeds": [
      "Thyrotoxicosis with diffuse goiter"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08290",
    "question": "What is associated with Spastic paraparesis and deafness?",
    "seeds": [
      "Spastic paraparesis and deafness"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08291",
    "question": "What is associated with Cervix cancer?",
    "seeds": [
      "Cervix cancer"
    ],
    "gold_answer": "Cervical neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08292",
    "question": "What phenotype is associated with Hypotrichosis 12?",
    "seeds": [
      "Hypotrichosis 12"
    ],
    "gold_answer": "Sparse axillary hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08293",
    "question": "What is associated with Everted upper lip vermilion?",
    "seeds": [
      "Everted upper lip vermilion"
    ],
    "gold_answer": "Abnormality of upper lip vermillion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08294",
    "question": "What is associated with Alport syndrome, X-linked?",
    "seeds": [
      "Alport syndrome, X-linked"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08295",
    "question": "What is associated with Abnormal dura mater morphology?",
    "seeds": [
      "Abnormal dura mater morphology"
    ],
    "gold_answer": "Abnormal meningeal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08296",
    "question": "What is associated with Complete breech presentation?",
    "seeds": [
      "Complete breech presentation"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08297",
    "question": "What phenotype is associated with Drug reaction with eosinophilia and systemic symptoms?",
    "seeds": [
      "Drug reaction with eosinophilia and systemic symptoms"
    ],
    "gold_answer": "Weight loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08298",
    "question": "What is associated with Anti-GM4 antibody positivity?",
    "seeds": [
      "Anti-GM4 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08299",
    "question": "What is associated with Hypogonadotropic hypogonadism 22 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 22 with or without anosmia"
    ],
    "gold_answer": "External genital hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08300",
    "question": "What is associated with Costovertebral angle tenderness?",
    "seeds": [
      "Costovertebral angle tenderness"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08301",
    "question": "What is associated with Ultra-low vision with no light perception?",
    "seeds": [
      "Ultra-low vision with no light perception"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08302",
    "question": "What is associated with Abnormality of the urethra?",
    "seeds": [
      "Abnormality of the urethra"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08303",
    "question": "What is associated with Moyamoya disease 7?",
    "seeds": [
      "Moyamoya disease 7"
    ],
    "gold_answer": "Weakness due to upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08304",
    "question": "What is associated with Neuritis?",
    "seeds": [
      "Neuritis"
    ],
    "gold_answer": "Abnormal peripheral nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08305",
    "question": "What phenotype is associated with TMEM70-related mitochondrial encephalo-cardio-myopathy?",
    "seeds": [
      "TMEM70-related mitochondrial encephalo-cardio-myopathy"
    ],
    "gold_answer": "Abnormal aortic valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08306",
    "question": "What is associated with Cold-Induced sweating syndrome 2?",
    "seeds": [
      "Cold-Induced sweating syndrome 2"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08307",
    "question": "What is associated with Myopathy with exercise intolerance, Swedish type?",
    "seeds": [
      "Myopathy with exercise intolerance, Swedish type"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08308",
    "question": "What is associated with ACTH-independent macronodular adrenal hyperplasia?",
    "seeds": [
      "ACTH-independent macronodular adrenal hyperplasia"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08309",
    "question": "What is associated with Recurrent cystitis?",
    "seeds": [
      "Recurrent cystitis"
    ],
    "gold_answer": "Recurrent urinary tract infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08310",
    "question": "What phenotype is associated with Dystonia 32?",
    "seeds": [
      "Dystonia 32"
    ],
    "gold_answer": "Limb dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08311",
    "question": "What is associated with Focal impaired awareness head nodding automatism seizure?",
    "seeds": [
      "Focal impaired awareness head nodding automatism seizure"
    ],
    "gold_answer": "Focal impaired awareness seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08312",
    "question": "What is associated with Curvilinear subcortical heterotopia?",
    "seeds": [
      "Curvilinear subcortical heterotopia"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08313",
    "question": "What is associated with Decreased platelet glycoprotein Ib-IX-V?",
    "seeds": [
      "Decreased platelet glycoprotein Ib-IX-V"
    ],
    "gold_answer": "Abnormality of thrombocytes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08314",
    "question": "What is associated with Congenital disorder of glycosylation, type IIh?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIh"
    ],
    "gold_answer": "Abnormal femoral neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08315",
    "question": "What is associated with Juvenile temporal arteritis?",
    "seeds": [
      "Juvenile temporal arteritis"
    ],
    "gold_answer": "Immunologic hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08316",
    "question": "What is associated with Isolated atrial standstill?",
    "seeds": [
      "Isolated atrial standstill"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08317",
    "question": "What phenotype is associated with Autosomal dominant mitochondrial myopathy with exercise intolerance?",
    "seeds": [
      "Autosomal dominant mitochondrial myopathy with exercise intolerance"
    ],
    "gold_answer": "Neck flexor weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08318",
    "question": "What is associated with Entamoeba histolytica antibody positive in stool?",
    "seeds": [
      "Entamoeba histolytica antibody positive in stool"
    ],
    "gold_answer": "Positive stool infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08319",
    "question": "What is associated with Aplasia of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Aplasia of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the proximal phalanx of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08320",
    "question": "What is associated with Absent radius-anogenital anomalies syndrome?",
    "seeds": [
      "Absent radius-anogenital anomalies syndrome"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08321",
    "question": "What is associated with Reduced granulocyte CD59 level?",
    "seeds": [
      "Reduced granulocyte CD59 level"
    ],
    "gold_answer": "Reduced granulocyte surface marker level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08322",
    "question": "What is associated with Benign Samaritan congenital myopathy?",
    "seeds": [
      "Benign Samaritan congenital myopathy"
    ],
    "gold_answer": "Abnormality of mouth size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08323",
    "question": "What is associated with Proximal tubulopathy?",
    "seeds": [
      "Proximal tubulopathy"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08324",
    "question": "What is associated with Neuronopathy, distal hereditary motor, type IID?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, type IID"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08325",
    "question": "What phenotype is associated with Spinocerebellar ataxia type 41?",
    "seeds": [
      "Spinocerebellar ataxia type 41"
    ],
    "gold_answer": "Gait ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08326",
    "question": "What phenotype is associated with Immunodeficiency 59 and hypoglycemia?",
    "seeds": [
      "Immunodeficiency 59 and hypoglycemia"
    ],
    "gold_answer": "Arteritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08327",
    "question": "What is associated with Absent epiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Absent epiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the middle phalanx of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08328",
    "question": "What is associated with Autosomal recessive cutis laxa type 2A?",
    "seeds": [
      "Autosomal recessive cutis laxa type 2A"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08329",
    "question": "What is associated with Functional motor deficit?",
    "seeds": [
      "Functional motor deficit"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08330",
    "question": "What is associated with Postexertional symptom exacerbation?",
    "seeds": [
      "Postexertional symptom exacerbation"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08331",
    "question": "What is associated with Localized to the lower eyelid?",
    "seeds": [
      "Localized to the lower eyelid"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08332",
    "question": "What is associated with Flexion contracture?",
    "seeds": [
      "Flexion contracture"
    ],
    "gold_answer": "Joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08333",
    "question": "What phenotype is associated with Kaposiform lymphangiomatosis?",
    "seeds": [
      "Kaposiform lymphangiomatosis"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08334",
    "question": "What is associated with Abnormal antitragus morphology?",
    "seeds": [
      "Abnormal antitragus morphology"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08335",
    "question": "What is associated with Arterial calcification?",
    "seeds": [
      "Arterial calcification"
    ],
    "gold_answer": "Cardiovascular calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08336",
    "question": "What is associated with Triangular epiphyses of the 4th finger?",
    "seeds": [
      "Triangular epiphyses of the 4th finger"
    ],
    "gold_answer": "Triangular epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08337",
    "question": "What is associated with Fibromatosis, gingival, 1?",
    "seeds": [
      "Fibromatosis, gingival, 1"
    ],
    "gold_answer": "Soft tissue sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08338",
    "question": "What phenotype is associated with Spastic paraplegia 9B, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 9B, autosomal recessive"
    ],
    "gold_answer": "Absent speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08339",
    "question": "What is associated with Abnormality of the epiphysis of the middle phalanx of the 2nd toe?",
    "seeds": [
      "Abnormality of the epiphysis of the middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08340",
    "question": "What is associated with Open comedo?",
    "seeds": [
      "Open comedo"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08341",
    "question": "What is associated with Triangular shaped proximal phalanx of the 2nd finger?",
    "seeds": [
      "Triangular shaped proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Triangular shaped proximal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08342",
    "question": "What is associated with Abnormal liver sonography?",
    "seeds": [
      "Abnormal liver sonography"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08343",
    "question": "What is associated with Abnormal ventricular filling?",
    "seeds": [
      "Abnormal ventricular filling"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08344",
    "question": "What is associated with Syndactyly-Polydactyly-Earlobe syndrome?",
    "seeds": [
      "Syndactyly-Polydactyly-Earlobe syndrome"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08345",
    "question": "What is associated with Facial expressions not directed to others?",
    "seeds": [
      "Facial expressions not directed to others"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08346",
    "question": "What phenotype is associated with Tatton-Brown-Rahman syndrome?",
    "seeds": [
      "Tatton-Brown-Rahman syndrome"
    ],
    "gold_answer": "Short toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08347",
    "question": "What is associated with Abnormal septum pellucidum morphology?",
    "seeds": [
      "Abnormal septum pellucidum morphology"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08348",
    "question": "What is associated with Abnormality of the thyroid gland?",
    "seeds": [
      "Abnormality of the thyroid gland"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08349",
    "question": "What is associated with Sonographic non-visualized fetal bladder?",
    "seeds": [
      "Sonographic non-visualized fetal bladder"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08350",
    "question": "What phenotype is associated with Amyloidosis, cutaneous bullous?",
    "seeds": [
      "Amyloidosis, cutaneous bullous"
    ],
    "gold_answer": "Amyloid deposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08351",
    "question": "What is associated with Migratory erythematous plaque?",
    "seeds": [
      "Migratory erythematous plaque"
    ],
    "gold_answer": "Erythema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08352",
    "question": "What is associated with Gombo syndrome?",
    "seeds": [
      "Gombo syndrome"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08353",
    "question": "What is associated with Increased CSF D-threitol concentration?",
    "seeds": [
      "Increased CSF D-threitol concentration"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08354",
    "question": "What is associated with Hypoplasia of facial musculature?",
    "seeds": [
      "Hypoplasia of facial musculature"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08355",
    "question": "What phenotype is associated with NTHL1-related polyposis?",
    "seeds": [
      "NTHL1-related polyposis"
    ],
    "gold_answer": "Non-Hodgkin lymphoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08356",
    "question": "What is associated with Abnormality of the epiphysis of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Abnormality of the epiphysis of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08357",
    "question": "What phenotype is associated with Triphalangeal thumb-polysyndactyly syndrome?",
    "seeds": [
      "Triphalangeal thumb-polysyndactyly syndrome"
    ],
    "gold_answer": "Preaxial hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08358",
    "question": "What is associated with Abnormal ventriculoarterial connection?",
    "seeds": [
      "Abnormal ventriculoarterial connection"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08359",
    "question": "What phenotype is associated with Fetal valproate spectrum disorder?",
    "seeds": [
      "Fetal valproate spectrum disorder"
    ],
    "gold_answer": "Narrow mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08360",
    "question": "What is associated with Partial absence of specific antibody response to unconjugated pneumococcus vaccine?",
    "seeds": [
      "Partial absence of specific antibody response to unconjugated pneumococcus vaccine"
    ],
    "gold_answer": "Decreased specific antibody response to polysaccharide vaccine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08361",
    "question": "What is associated with Abnormal ulnar epiphysis morphology?",
    "seeds": [
      "Abnormal ulnar epiphysis morphology"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08362",
    "question": "What is associated with Squamous metaplasia?",
    "seeds": [
      "Squamous metaplasia"
    ],
    "gold_answer": "Histopathological abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08363",
    "question": "What is associated with Ameliorated by acetazolamide?",
    "seeds": [
      "Ameliorated by acetazolamide"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08364",
    "question": "What is associated with Abnormal total natural killer cell count?",
    "seeds": [
      "Abnormal total natural killer cell count"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08365",
    "question": "What is associated with Fulminant hepatitis?",
    "seeds": [
      "Fulminant hepatitis"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08366",
    "question": "What is associated with Nonossified fifth metatarsal?",
    "seeds": [
      "Nonossified fifth metatarsal"
    ],
    "gold_answer": "Abnormal metatarsal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08367",
    "question": "What is associated with Splenic hemophagocytosis?",
    "seeds": [
      "Splenic hemophagocytosis"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08368",
    "question": "What is associated with Congenital tricuspid valve dysplasia?",
    "seeds": [
      "Congenital tricuspid valve dysplasia"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08369",
    "question": "What is associated with Cervical (neck)?",
    "seeds": [
      "Cervical (neck)"
    ],
    "gold_answer": "Localized",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08370",
    "question": "What is associated with Broad 3rd toe?",
    "seeds": [
      "Broad 3rd toe"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08371",
    "question": "What phenotype is associated with Macular dystrophy, vitelliform, 4?",
    "seeds": [
      "Macular dystrophy, vitelliform, 4"
    ],
    "gold_answer": "Drusen",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08372",
    "question": "What is associated with Premature epimetaphyseal fusion in fibula?",
    "seeds": [
      "Premature epimetaphyseal fusion in fibula"
    ],
    "gold_answer": "Premature epimetaphyseal fusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08373",
    "question": "What is associated with Ectopic respiratory mucosa?",
    "seeds": [
      "Ectopic respiratory mucosa"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08374",
    "question": "What phenotype is associated with Flat face-microstomia-ear anomaly syndrome?",
    "seeds": [
      "Flat face-microstomia-ear anomaly syndrome"
    ],
    "gold_answer": "Inguinal hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08375",
    "question": "What phenotype is associated with Immunodeficiency 19?",
    "seeds": [
      "Immunodeficiency 19"
    ],
    "gold_answer": "Decreased total T cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08376",
    "question": "What is associated with Velo-facial-skeletal syndrome?",
    "seeds": [
      "Velo-facial-skeletal syndrome"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08377",
    "question": "What is associated with Recurrent bacterial skin infections?",
    "seeds": [
      "Recurrent bacterial skin infections"
    ],
    "gold_answer": "Recurrent skin infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08378",
    "question": "What is associated with Sloping forehead?",
    "seeds": [
      "Sloping forehead"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08379",
    "question": "What is associated with Highly elevated creatine kinase?",
    "seeds": [
      "Highly elevated creatine kinase"
    ],
    "gold_answer": "Elevated circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08380",
    "question": "What is associated with Histiocytosis-lymphadenopathy plus syndrome?",
    "seeds": [
      "Histiocytosis-lymphadenopathy plus syndrome"
    ],
    "gold_answer": "Hypopituitarism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08381",
    "question": "What is associated with Open neural tube defect?",
    "seeds": [
      "Open neural tube defect"
    ],
    "gold_answer": "Abnormal neural tube morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08382",
    "question": "What is associated with Deviation of finger?",
    "seeds": [
      "Deviation of finger"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08383",
    "question": "What is associated with Unilateral radial aplasia?",
    "seeds": [
      "Unilateral radial aplasia"
    ],
    "gold_answer": "Abnormal morphology of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08384",
    "question": "What is associated with Primary dystonia, DYT21 type?",
    "seeds": [
      "Primary dystonia, DYT21 type"
    ],
    "gold_answer": "Dysphonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08385",
    "question": "What is associated with Absent zona pellucida?",
    "seeds": [
      "Absent zona pellucida"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08386",
    "question": "What is associated with Centronuclear myopathy 1?",
    "seeds": [
      "Centronuclear myopathy 1"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08387",
    "question": "What is associated with Epidermolytic palmoplantar keratoderma?",
    "seeds": [
      "Epidermolytic palmoplantar keratoderma"
    ],
    "gold_answer": "Abnormality of the plantar skin of foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08388",
    "question": "What is associated with Preauricular skin tag?",
    "seeds": [
      "Preauricular skin tag"
    ],
    "gold_answer": "Abnormal periauricular region morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08389",
    "question": "What is associated with Hydrocephalus-costovertebral dysplasia-Sprengel anomaly syndrome?",
    "seeds": [
      "Hydrocephalus-costovertebral dysplasia-Sprengel anomaly syndrome"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08390",
    "question": "What is associated with Spermatogenic failure, X-linked, 5?",
    "seeds": [
      "Spermatogenic failure, X-linked, 5"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08391",
    "question": "What is associated with Short distal phalanx of the 4th finger?",
    "seeds": [
      "Short distal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08392",
    "question": "What is associated with Developmental delay-language impairment-dopa responsive dystonia-parkinsonism syndrome due to 2q24 microdeletion?",
    "seeds": [
      "Developmental delay-language impairment-dopa responsive dystonia-parkinsonism syndrome due to 2q24 microdeletion"
    ],
    "gold_answer": "Abnormality of the philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08393",
    "question": "What is associated with Increased circulating very long-chain fatty acid concentration?",
    "seeds": [
      "Increased circulating very long-chain fatty acid concentration"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08394",
    "question": "What is associated with Protruding tongue?",
    "seeds": [
      "Protruding tongue"
    ],
    "gold_answer": "Abnormality of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08395",
    "question": "What is associated with Alzheimer disease 2?",
    "seeds": [
      "Alzheimer disease 2"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08396",
    "question": "What is associated with Shukla-Vernon syndrome?",
    "seeds": [
      "Shukla-Vernon syndrome"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08397",
    "question": "What is associated with Lipomas of eyelids?",
    "seeds": [
      "Lipomas of eyelids"
    ],
    "gold_answer": "Lipoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08398",
    "question": "What is associated with Cardiofaciocutaneous syndrome 1?",
    "seeds": [
      "Cardiofaciocutaneous syndrome 1"
    ],
    "gold_answer": "Hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08399",
    "question": "What is associated with Abnormal Humphrey SITA 10-2 perimetry test?",
    "seeds": [
      "Abnormal Humphrey SITA 10-2 perimetry test"
    ],
    "gold_answer": "Abnormal static automated perimetry test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08400",
    "question": "What is associated with Xeroderma pigmentosum, variant type?",
    "seeds": [
      "Xeroderma pigmentosum, variant type"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08401",
    "question": "What is associated with Intestinal lymphoid nodular hyperplasia?",
    "seeds": [
      "Intestinal lymphoid nodular hyperplasia"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08402",
    "question": "What is associated with Abnormal CSF branched chain amino acid concentration?",
    "seeds": [
      "Abnormal CSF branched chain amino acid concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08403",
    "question": "What is associated with Palate telangiectasia?",
    "seeds": [
      "Palate telangiectasia"
    ],
    "gold_answer": "Telangiectasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08404",
    "question": "What is associated with Unilateral facial palsy?",
    "seeds": [
      "Unilateral facial palsy"
    ],
    "gold_answer": "Facial palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08405",
    "question": "What is associated with Enlarged epiphysis of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Enlarged epiphysis of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08406",
    "question": "What is associated with Abnormal gamma-delta T cell proportion?",
    "seeds": [
      "Abnormal gamma-delta T cell proportion"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08407",
    "question": "What is associated with Lipoatrophy?",
    "seeds": [
      "Lipoatrophy"
    ],
    "gold_answer": "Lipodystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08408",
    "question": "What is associated with Aplasia of the vestibular nerve?",
    "seeds": [
      "Aplasia of the vestibular nerve"
    ],
    "gold_answer": "Abnormal inner ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08409",
    "question": "What is associated with Anti-MAP1B antibody?",
    "seeds": [
      "Anti-MAP1B antibody"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08410",
    "question": "What is associated with Duplication of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Duplication of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Mesoaxial hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08411",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 43?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 43"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08412",
    "question": "What is associated with Decreased biparietal diameter?",
    "seeds": [
      "Decreased biparietal diameter"
    ],
    "gold_answer": "Abnormal biparietal diameter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08413",
    "question": "What is associated with Dyslexia, susceptibility to, 8?",
    "seeds": [
      "Dyslexia, susceptibility to, 8"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08414",
    "question": "What is associated with Aortic aneurysm, familial thoracic 10?",
    "seeds": [
      "Aortic aneurysm, familial thoracic 10"
    ],
    "gold_answer": "Aortic aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08415",
    "question": "What is associated with Cyanotic episode?",
    "seeds": [
      "Cyanotic episode"
    ],
    "gold_answer": "Cyanosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08416",
    "question": "What is associated with Thought echo?",
    "seeds": [
      "Thought echo"
    ],
    "gold_answer": "Disordered formal thought process",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08417",
    "question": "What is associated with Foveal degeneration?",
    "seeds": [
      "Foveal degeneration"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08418",
    "question": "What is associated with Elevated brain glutamine level by MRS?",
    "seeds": [
      "Elevated brain glutamine level by MRS"
    ],
    "gold_answer": "Abnormal metabolic brain imaging by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08419",
    "question": "What phenotype is associated with Schizophrenia 3?",
    "seeds": [
      "Schizophrenia 3"
    ],
    "gold_answer": "Schizophrenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08420",
    "question": "What is associated with Decreased circulating vitamin B8 concentration?",
    "seeds": [
      "Decreased circulating vitamin B8 concentration"
    ],
    "gold_answer": "Abnormality of vitamin metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08421",
    "question": "What is associated with Parotitis?",
    "seeds": [
      "Parotitis"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08422",
    "question": "What is associated with Pancreatic cancer, susceptibility to, 1?",
    "seeds": [
      "Pancreatic cancer, susceptibility to, 1"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08423",
    "question": "What is associated with Hereditary painful callosities?",
    "seeds": [
      "Hereditary painful callosities"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08424",
    "question": "What is associated with Dystrophic epidermolysis bullosa pruriginosa?",
    "seeds": [
      "Dystrophic epidermolysis bullosa pruriginosa"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08425",
    "question": "What is associated with Reduced MHC II cell surface expression?",
    "seeds": [
      "Reduced MHC II cell surface expression"
    ],
    "gold_answer": "Abnormal MHC surface expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08426",
    "question": "What is associated with Sebaceous gland hyperplasia, familial presenile?",
    "seeds": [
      "Sebaceous gland hyperplasia, familial presenile"
    ],
    "gold_answer": "Abnormal sebaceous gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08427",
    "question": "What is associated with Congenital lobar overinflation?",
    "seeds": [
      "Congenital lobar overinflation"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08428",
    "question": "What is associated with Spondyloepiphyseal dysplasia congenita?",
    "seeds": [
      "Spondyloepiphyseal dysplasia congenita"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08429",
    "question": "What is associated with Progressive leg bowing?",
    "seeds": [
      "Progressive leg bowing"
    ],
    "gold_answer": "Bowing of the long bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08430",
    "question": "What phenotype is associated with Heme oxygenase-1 deficiency?",
    "seeds": [
      "Heme oxygenase-1 deficiency"
    ],
    "gold_answer": "Hepatomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08431",
    "question": "What is associated with Fragmentation of the epiphysis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Fragmentation of the epiphysis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Fragmentation of the epiphyses of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08432",
    "question": "What is associated with 17q11 microdeletion syndrome?",
    "seeds": [
      "17q11 microdeletion syndrome"
    ],
    "gold_answer": "JAG1",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08433",
    "question": "What is associated with Deafness, autosomal dominant nonsyndromic sensorineural 49?",
    "seeds": [
      "Deafness, autosomal dominant nonsyndromic sensorineural 49"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08434",
    "question": "What is associated with Idiopathic bilateral vestibulopathy?",
    "seeds": [
      "Idiopathic bilateral vestibulopathy"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08435",
    "question": "What is associated with Triphalangeal thumb with double phalanges?",
    "seeds": [
      "Triphalangeal thumb with double phalanges"
    ],
    "gold_answer": "Complete duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08436",
    "question": "What is associated with Increased airway neuroendocrine cells?",
    "seeds": [
      "Increased airway neuroendocrine cells"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08437",
    "question": "What is associated with Anti-Epstein-Barr virus-specific antibody positivity?",
    "seeds": [
      "Anti-Epstein-Barr virus-specific antibody positivity"
    ],
    "gold_answer": "Bloodstream virus-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08438",
    "question": "What phenotype is associated with Developmental delay with short stature, dysmorphic facial features, and sparse hair 2?",
    "seeds": [
      "Developmental delay with short stature, dysmorphic facial features, and sparse hair 2"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08439",
    "question": "What is associated with Hypertrichotic hyperpigmented patch?",
    "seeds": [
      "Hypertrichotic hyperpigmented patch"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08440",
    "question": "What is associated with Abnormal sacral segmentation?",
    "seeds": [
      "Abnormal sacral segmentation"
    ],
    "gold_answer": "Vertebral segmentation defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08441",
    "question": "What is associated with Autosomal dominant adult-onset proximal spinal muscular atrophy?",
    "seeds": [
      "Autosomal dominant adult-onset proximal spinal muscular atrophy"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08442",
    "question": "What is associated with Primary dystonia, DYT27 type?",
    "seeds": [
      "Primary dystonia, DYT27 type"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08443",
    "question": "What is associated with Thin corpus callosum?",
    "seeds": [
      "Thin corpus callosum"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08444",
    "question": "What phenotype is associated with Deafness, autosomal recessive 18B?",
    "seeds": [
      "Deafness, autosomal recessive 18B"
    ],
    "gold_answer": "Vestibular hyporeflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08445",
    "question": "What is associated with Ectopic thymus tissue?",
    "seeds": [
      "Ectopic thymus tissue"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08446",
    "question": "What is associated with Ureteral polyp?",
    "seeds": [
      "Ureteral polyp"
    ],
    "gold_answer": "Neoplasm of the genitourinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08447",
    "question": "What is associated with Hyperchromasia of renal tubular epithelial cells?",
    "seeds": [
      "Hyperchromasia of renal tubular epithelial cells"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08448",
    "question": "What is associated with Decreased circulating hydroxyproline concentration?",
    "seeds": [
      "Decreased circulating hydroxyproline concentration"
    ],
    "gold_answer": "Abnormal circulating proline concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08449",
    "question": "What is associated with Appendiceal mucinous neoplasm?",
    "seeds": [
      "Appendiceal mucinous neoplasm"
    ],
    "gold_answer": "Glandular cell neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08450",
    "question": "What is associated with Holocarboxylase synthetase deficiency?",
    "seeds": [
      "Holocarboxylase synthetase deficiency"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08451",
    "question": "What is associated with Fetal cyclophosphamide exposure?",
    "seeds": [
      "Fetal cyclophosphamide exposure"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08452",
    "question": "What is associated with Increased urinary zinc level?",
    "seeds": [
      "Increased urinary zinc level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08453",
    "question": "What is associated with Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset?",
    "seeds": [
      "Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08454",
    "question": "What is associated with Skin tenting due to fracture?",
    "seeds": [
      "Skin tenting due to fracture"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08455",
    "question": "What is associated with Abnormality of glycosaminoglycan metabolism?",
    "seeds": [
      "Abnormality of glycosaminoglycan metabolism"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08456",
    "question": "What is associated with Tan-Almurshedi syndrome?",
    "seeds": [
      "Tan-Almurshedi syndrome"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08457",
    "question": "What is associated with Hypotrichosis-intellectual disability, Lopes type?",
    "seeds": [
      "Hypotrichosis-intellectual disability, Lopes type"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08458",
    "question": "What is associated with Acrorenal syndrome?",
    "seeds": [
      "Acrorenal syndrome"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08459",
    "question": "What is associated with Asymmetric blood pressure between arms?",
    "seeds": [
      "Asymmetric blood pressure between arms"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08460",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, X-linked dominant, 6?",
    "seeds": [
      "Charcot-Marie-Tooth disease, X-linked dominant, 6"
    ],
    "gold_answer": "Distal lower limb amyotrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08461",
    "question": "What phenotype is associated with Myopathy, sarcoplasmic body?",
    "seeds": [
      "Myopathy, sarcoplasmic body"
    ],
    "gold_answer": "Weakness of the intrinsic hand muscles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08462",
    "question": "What is associated with Edema?",
    "seeds": [
      "Edema"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08463",
    "question": "What phenotype is associated with Hypoparathyroidism-sensorineural deafness-renal disease syndrome?",
    "seeds": [
      "Hypoparathyroidism-sensorineural deafness-renal disease syndrome"
    ],
    "gold_answer": "Vaginal atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08464",
    "question": "What is associated with Ankle swelling?",
    "seeds": [
      "Ankle swelling"
    ],
    "gold_answer": "Abnormality of the ankle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08465",
    "question": "What is associated with Alaninuria?",
    "seeds": [
      "Alaninuria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08466",
    "question": "What is associated with Decreased iduronate sulfatase level?",
    "seeds": [
      "Decreased iduronate sulfatase level"
    ],
    "gold_answer": "Abnormal iduronate sulfatase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08467",
    "question": "What is associated with Profound hearing impairment?",
    "seeds": [
      "Profound hearing impairment"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08468",
    "question": "What phenotype is associated with Cranial nerves, congenital paresis of?",
    "seeds": [
      "Cranial nerves, congenital paresis of"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08469",
    "question": "What is associated with Mycobacterial and viral infections, susceptibility to, autosomal recessive?",
    "seeds": [
      "Mycobacterial and viral infections, susceptibility to, autosomal recessive"
    ],
    "gold_answer": "Infectious encephalitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08470",
    "question": "What is associated with Cone-shaped epiphyses of the hallux?",
    "seeds": [
      "Cone-shaped epiphyses of the hallux"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08471",
    "question": "What phenotype is associated with Mitochondrial DNA depletion syndrome 2 (myopathic type)?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 2 (myopathic type)"
    ],
    "gold_answer": "Decreased activity of mitochondrial ATP synthase complex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08472",
    "question": "What is associated with Recurrent infection of the gastrointestinal tract?",
    "seeds": [
      "Recurrent infection of the gastrointestinal tract"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08473",
    "question": "What is associated with Widened cerebellar subarachnoid space?",
    "seeds": [
      "Widened cerebellar subarachnoid space"
    ],
    "gold_answer": "Widened subarachnoid space",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08474",
    "question": "What is associated with Spastic ataxia 11, autosomal dominant?",
    "seeds": [
      "Spastic ataxia 11, autosomal dominant"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08475",
    "question": "What is associated with Spinocerebellar ataxia 23?",
    "seeds": [
      "Spinocerebellar ataxia 23"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08476",
    "question": "What is associated with Bifid antitragus?",
    "seeds": [
      "Bifid antitragus"
    ],
    "gold_answer": "Abnormal antitragus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08477",
    "question": "What is associated with Short stature-delayed bone age due to thyroid hormone metabolism deficiency?",
    "seeds": [
      "Short stature-delayed bone age due to thyroid hormone metabolism deficiency"
    ],
    "gold_answer": "Proximal muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08478",
    "question": "What is associated with Posterior corneal stroma punctiform multicolored opacities?",
    "seeds": [
      "Posterior corneal stroma punctiform multicolored opacities"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08479",
    "question": "What is associated with Ciliary dyskinesia, primary, 28?",
    "seeds": [
      "Ciliary dyskinesia, primary, 28"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08480",
    "question": "What is associated with Increased mean platelet volume?",
    "seeds": [
      "Increased mean platelet volume"
    ],
    "gold_answer": "Abnormality of thrombocytes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08481",
    "question": "What is associated with Abnormality of coordination?",
    "seeds": [
      "Abnormality of coordination"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08482",
    "question": "What phenotype is associated with Autosomal recessive palmoplantar keratoderma and congenital alopecia?",
    "seeds": [
      "Autosomal recessive palmoplantar keratoderma and congenital alopecia"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08483",
    "question": "What is associated with Nemaline myopathy 5C, autosomal dominant?",
    "seeds": [
      "Nemaline myopathy 5C, autosomal dominant"
    ],
    "gold_answer": "Abnormal scapula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08484",
    "question": "What phenotype is associated with Macrocephaly, alopecia, cutis laxa, and scoliosis?",
    "seeds": [
      "Macrocephaly, alopecia, cutis laxa, and scoliosis"
    ],
    "gold_answer": "Palpebral edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08485",
    "question": "What is associated with Pulmonary situs ambiguus with bilateral morphologic left lungs?",
    "seeds": [
      "Pulmonary situs ambiguus with bilateral morphologic left lungs"
    ],
    "gold_answer": "Abnormal pulmonary situs morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08486",
    "question": "What is associated with Prominent nasolabial fold?",
    "seeds": [
      "Prominent nasolabial fold"
    ],
    "gold_answer": "Abnormal nasolabial region morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08487",
    "question": "What is associated with Diaphragmatic eventration?",
    "seeds": [
      "Diaphragmatic eventration"
    ],
    "gold_answer": "Abnormality of the diaphragm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08488",
    "question": "What is associated with Isolated focal cortical dysplasia type IIb?",
    "seeds": [
      "Isolated focal cortical dysplasia type IIb"
    ],
    "gold_answer": "TSC2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08489",
    "question": "What phenotype is associated with Deafness, autosomal recessive 53?",
    "seeds": [
      "Deafness, autosomal recessive 53"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08490",
    "question": "What is associated with Abnormality of the epiphysis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Abnormality of the epiphysis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal 3rd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08491",
    "question": "What is associated with Warburg micro syndrome 3?",
    "seeds": [
      "Warburg micro syndrome 3"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08492",
    "question": "What is associated with Postprandial fullness?",
    "seeds": [
      "Postprandial fullness"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08493",
    "question": "What is associated with DUODENAL ULCER DUE TO ANTRAL G-CELL HYPERFUNCTION?",
    "seeds": [
      "DUODENAL ULCER DUE TO ANTRAL G-CELL HYPERFUNCTION"
    ],
    "gold_answer": "Abnormal duodenum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08494",
    "question": "What is associated with Osteogenesis imperfecta, type XXIII?",
    "seeds": [
      "Osteogenesis imperfecta, type XXIII"
    ],
    "gold_answer": "Abnormal femoral head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08495",
    "question": "What is associated with Increased circulating interleukin 1beta concentration?",
    "seeds": [
      "Increased circulating interleukin 1beta concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08496",
    "question": "What is associated with Abnormal HLA DR+ CD8+ T cell proportion?",
    "seeds": [
      "Abnormal HLA DR+ CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08497",
    "question": "What is associated with Poliomyelitis?",
    "seeds": [
      "Poliomyelitis"
    ],
    "gold_answer": "Abnormal nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08498",
    "question": "What is associated with Neonatal multifocal clonic seizure?",
    "seeds": [
      "Neonatal multifocal clonic seizure"
    ],
    "gold_answer": "Neonatal electro-clinical motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08499",
    "question": "What is associated with Thyroid atypical adenoma?",
    "seeds": [
      "Thyroid atypical adenoma"
    ],
    "gold_answer": "Neoplasm of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08500",
    "question": "What is associated with Cataract 13 with adult i phenotype?",
    "seeds": [
      "Cataract 13 with adult i phenotype"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08501",
    "question": "What is associated with Comedo?",
    "seeds": [
      "Comedo"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08502",
    "question": "What phenotype is associated with Van den bosch syndrome?",
    "seeds": [
      "Van den bosch syndrome"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08503",
    "question": "What is associated with Asymmetry of the position of the ears?",
    "seeds": [
      "Asymmetry of the position of the ears"
    ],
    "gold_answer": "Asymmetry of the ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08504",
    "question": "What is associated with Hyperserinemia?",
    "seeds": [
      "Hyperserinemia"
    ],
    "gold_answer": "Abnormal circulating serine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08505",
    "question": "What is associated with Pulmonary artery hypoplasia?",
    "seeds": [
      "Pulmonary artery hypoplasia"
    ],
    "gold_answer": "Abnormality of the pulmonary vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08506",
    "question": "What is associated with Histiocytosis-lymphadenopathy plus syndrome?",
    "seeds": [
      "Histiocytosis-lymphadenopathy plus syndrome"
    ],
    "gold_answer": "Abnormal morphology of the nasal alae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08507",
    "question": "What is associated with Subretinal hemorrhage?",
    "seeds": [
      "Subretinal hemorrhage"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08508",
    "question": "What phenotype is associated with Hyperparathyroidism, neonatal severe?",
    "seeds": [
      "Hyperparathyroidism, neonatal severe"
    ],
    "gold_answer": "Hypercalciuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08509",
    "question": "What is associated with Chronic recurrent multifocal osteomyelitis?",
    "seeds": [
      "Chronic recurrent multifocal osteomyelitis"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08510",
    "question": "What is associated with Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome?",
    "seeds": [
      "Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08511",
    "question": "What is associated with Vascular dilatation?",
    "seeds": [
      "Vascular dilatation"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08512",
    "question": "What is associated with Indomethacin embryofetopathy?",
    "seeds": [
      "Indomethacin embryofetopathy"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08513",
    "question": "What is associated with Vesicoallantoic abdominal wall defect?",
    "seeds": [
      "Vesicoallantoic abdominal wall defect"
    ],
    "gold_answer": "Abnormal bladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08514",
    "question": "What is associated with Bronchogenic cyst?",
    "seeds": [
      "Bronchogenic cyst"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08515",
    "question": "What is associated with Idiopathic aplastic anemia?",
    "seeds": [
      "Idiopathic aplastic anemia"
    ],
    "gold_answer": "TERT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_08516",
    "question": "What is associated with Intellectual disability?",
    "seeds": [
      "Intellectual disability"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08517",
    "question": "What is associated with Nasal flaring?",
    "seeds": [
      "Nasal flaring"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08518",
    "question": "What is associated with Vaginal birth after Caesarean?",
    "seeds": [
      "Vaginal birth after Caesarean"
    ],
    "gold_answer": "Abnormal delivery",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08519",
    "question": "What phenotype is associated with Dopamine beta-hydroxylase deficiency?",
    "seeds": [
      "Dopamine beta-hydroxylase deficiency"
    ],
    "gold_answer": "Hypoglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08520",
    "question": "What is associated with Ichthyosis, follicular, with atrichia and photophobia syndrome 2?",
    "seeds": [
      "Ichthyosis, follicular, with atrichia and photophobia syndrome 2"
    ],
    "gold_answer": "Ichthyosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08521",
    "question": "What is associated with Aplastic/hypoplastic lacrimal glands?",
    "seeds": [
      "Aplastic/hypoplastic lacrimal glands"
    ],
    "gold_answer": "Abnormal lacrimal gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08522",
    "question": "What is associated with Retinal dystrophy and microvillus inclusion disease?",
    "seeds": [
      "Retinal dystrophy and microvillus inclusion disease"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08523",
    "question": "What is associated with Delusion?",
    "seeds": [
      "Delusion"
    ],
    "gold_answer": "Abnormal cognitive process",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08524",
    "question": "What is associated with Infratentorial superficial CNS hemosiderin deposition?",
    "seeds": [
      "Infratentorial superficial CNS hemosiderin deposition"
    ],
    "gold_answer": "Superficial CNS hemosiderin deposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08525",
    "question": "What phenotype is associated with Saethre-Chotzen syndrome?",
    "seeds": [
      "Saethre-Chotzen syndrome"
    ],
    "gold_answer": "Flat forehead",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08526",
    "question": "What is associated with Diminishment of relationship seeking?",
    "seeds": [
      "Diminishment of relationship seeking"
    ],
    "gold_answer": "Abnormal change in social behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08527",
    "question": "What is associated with Neurodevelopmental disorder with microcephaly, seizures, and brain atrophy?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, seizures, and brain atrophy"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08528",
    "question": "What phenotype is associated with Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation?",
    "seeds": [
      "Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08529",
    "question": "What is associated with Spinocerebellar ataxia type 19/22?",
    "seeds": [
      "Spinocerebellar ataxia type 19/22"
    ],
    "gold_answer": "Impaired vibratory sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08530",
    "question": "What is associated with Aplasia of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Aplasia of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the proximal phalanx of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08531",
    "question": "What is associated with Abnormal arcuate vein intima/media morphology?",
    "seeds": [
      "Abnormal arcuate vein intima/media morphology"
    ],
    "gold_answer": "Abnormal arcuate vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08532",
    "question": "What is associated with Abnormal muscle fiber laminin beta 1?",
    "seeds": [
      "Abnormal muscle fiber laminin beta 1"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08533",
    "question": "What is associated with Large radial epiphyses?",
    "seeds": [
      "Large radial epiphyses"
    ],
    "gold_answer": "Enlarged epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08534",
    "question": "What is associated with Low neutrophil alkaline phosphatase?",
    "seeds": [
      "Low neutrophil alkaline phosphatase"
    ],
    "gold_answer": "Abnormality of alkaline phosphatase level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08535",
    "question": "What is associated with Fractured epiphysis of third metacarpal bone?",
    "seeds": [
      "Fractured epiphysis of third metacarpal bone"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08536",
    "question": "What is associated with Reverse typical atrial flutter?",
    "seeds": [
      "Reverse typical atrial flutter"
    ],
    "gold_answer": "Atrial arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08537",
    "question": "What is associated with Pain at the medial aspect of the knee?",
    "seeds": [
      "Pain at the medial aspect of the knee"
    ],
    "gold_answer": "Knee pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08538",
    "question": "What is associated with Diabetes mellitus, insulin-dependent, 2?",
    "seeds": [
      "Diabetes mellitus, insulin-dependent, 2"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08539",
    "question": "What is associated with Deafness, autosomal recessive 1B?",
    "seeds": [
      "Deafness, autosomal recessive 1B"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08540",
    "question": "What is associated with Abnormality of the pulmonary veins?",
    "seeds": [
      "Abnormality of the pulmonary veins"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08541",
    "question": "What is associated with Severe giardiasis?",
    "seeds": [
      "Severe giardiasis"
    ],
    "gold_answer": "Unusual protozoan infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08542",
    "question": "What is associated with Septic embolism?",
    "seeds": [
      "Septic embolism"
    ],
    "gold_answer": "Abnormal thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08543",
    "question": "What is associated with Increased fetal movement?",
    "seeds": [
      "Increased fetal movement"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08544",
    "question": "What phenotype is associated with Verrucous hemangioma?",
    "seeds": [
      "Verrucous hemangioma"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08545",
    "question": "What is associated with Temple syndrome due to paternal 14q32.2 microdeletion?",
    "seeds": [
      "Temple syndrome due to paternal 14q32.2 microdeletion"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08546",
    "question": "What is associated with Obesity and hypopigmentation?",
    "seeds": [
      "Obesity and hypopigmentation"
    ],
    "gold_answer": "Abnormal consumption behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08547",
    "question": "What is associated with Microtia with meatal atresia and conductive deafness?",
    "seeds": [
      "Microtia with meatal atresia and conductive deafness"
    ],
    "gold_answer": "Functional abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08548",
    "question": "What is associated with High-frequency hearing impairment?",
    "seeds": [
      "High-frequency hearing impairment"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08549",
    "question": "What is associated with Peripheral arteriovenous fistula?",
    "seeds": [
      "Peripheral arteriovenous fistula"
    ],
    "gold_answer": "Arteriovenous malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08550",
    "question": "What is associated with Small epiphysis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Small epiphysis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Small epiphyses of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08551",
    "question": "What is associated with Urethral stricture?",
    "seeds": [
      "Urethral stricture"
    ],
    "gold_answer": "Abnormality of the urethra",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08552",
    "question": "What is associated with Abnormal alpha granule content?",
    "seeds": [
      "Abnormal alpha granule content"
    ],
    "gold_answer": "Abnormal alpha granules",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08553",
    "question": "What phenotype is associated with Dyskeratosis congenita, digenic?",
    "seeds": [
      "Dyskeratosis congenita, digenic"
    ],
    "gold_answer": "Esophageal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08554",
    "question": "What is associated with Increased CD8+ T cell proportion?",
    "seeds": [
      "Increased CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08555",
    "question": "What is associated with Keratosis palmoplantaris striata I?",
    "seeds": [
      "Keratosis palmoplantaris striata I"
    ],
    "gold_answer": "Abnormality of skin adnexa physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08556",
    "question": "What is associated with Arthropathy?",
    "seeds": [
      "Arthropathy"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08557",
    "question": "What is associated with Focal aware autonomic seizure with hypoventilation/hyperventilation/altered respiration?",
    "seeds": [
      "Focal aware autonomic seizure with hypoventilation/hyperventilation/altered respiration"
    ],
    "gold_answer": "Focal aware non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08558",
    "question": "What is associated with Muscular dystrophy, limb-girdle, autosomal recessive 10?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, autosomal recessive 10"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08559",
    "question": "What is associated with Increased circulating interleukin 2 concentration?",
    "seeds": [
      "Increased circulating interleukin 2 concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08560",
    "question": "What is associated with L-looping of the right ventricle?",
    "seeds": [
      "L-looping of the right ventricle"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08561",
    "question": "What phenotype is associated with Neuroendocrine tumor of anal canal?",
    "seeds": [
      "Neuroendocrine tumor of anal canal"
    ],
    "gold_answer": "Protracted diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08562",
    "question": "What is associated with Chromosome 16p12.2-p11.2 deletion syndrome, 7.1- to 8.7-mb?",
    "seeds": [
      "Chromosome 16p12.2-p11.2 deletion syndrome, 7.1- to 8.7-mb"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08563",
    "question": "What is associated with Decreased CSF 3-methoxy-4-hydroxyphenylglycolaldehyde concentration?",
    "seeds": [
      "Decreased CSF 3-methoxy-4-hydroxyphenylglycolaldehyde concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08564",
    "question": "What is associated with Decreased DLCO?",
    "seeds": [
      "Decreased DLCO"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08565",
    "question": "What phenotype is associated with MEDULLOBLASTOMA?",
    "seeds": [
      "MEDULLOBLASTOMA"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08566",
    "question": "What is associated with Aplasia of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Aplasia of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Finger aplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08567",
    "question": "What is associated with Frontotemporal dementia and/or amyotrophic lateral sclerosis 5?",
    "seeds": [
      "Frontotemporal dementia and/or amyotrophic lateral sclerosis 5"
    ],
    "gold_answer": "Abnormal superficial reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08568",
    "question": "What is associated with Heyn-Sproul-Jackson syndrome?",
    "seeds": [
      "Heyn-Sproul-Jackson syndrome"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08569",
    "question": "What is associated with Bacteremia?",
    "seeds": [
      "Bacteremia"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08570",
    "question": "What phenotype is associated with Epilepsy with auditory features?",
    "seeds": [
      "Epilepsy with auditory features"
    ],
    "gold_answer": "Auditory hallucinations",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08571",
    "question": "What is associated with Abnormality of the phalanges of the 5th toe?",
    "seeds": [
      "Abnormality of the phalanges of the 5th toe"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08572",
    "question": "What is associated with Bilateral basal ganglia lesions?",
    "seeds": [
      "Bilateral basal ganglia lesions"
    ],
    "gold_answer": "Abnormal basal ganglia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08573",
    "question": "What is associated with Chondrodysplasia punctata, Tibia-Metacarpal type?",
    "seeds": [
      "Chondrodysplasia punctata, Tibia-Metacarpal type"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08574",
    "question": "What phenotype is associated with Intellectual developmental disorder with epilepsy, behavioral abnormalities, and coarse facies?",
    "seeds": [
      "Intellectual developmental disorder with epilepsy, behavioral abnormalities, and coarse facies"
    ],
    "gold_answer": "Hyperactivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08575",
    "question": "What is associated with Sternocleidomastoid amyotrophy?",
    "seeds": [
      "Sternocleidomastoid amyotrophy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08576",
    "question": "What phenotype is associated with Spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome?",
    "seeds": [
      "Spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome"
    ],
    "gold_answer": "Wide nasal bridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08577",
    "question": "What is associated with Mild receptive language delay?",
    "seeds": [
      "Mild receptive language delay"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08578",
    "question": "What is associated with Decreased circulating adenosylcobalamin concentration?",
    "seeds": [
      "Decreased circulating adenosylcobalamin concentration"
    ],
    "gold_answer": "Abnormality of vitamin B12 metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08579",
    "question": "What is associated with Thick hair?",
    "seeds": [
      "Thick hair"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08580",
    "question": "What is associated with Monoclonal elevation of IgG?",
    "seeds": [
      "Monoclonal elevation of IgG"
    ],
    "gold_answer": "Increased circulating IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08581",
    "question": "What is associated with Coronary artery fistula?",
    "seeds": [
      "Coronary artery fistula"
    ],
    "gold_answer": "Abnormal coronary artery course",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08582",
    "question": "What is associated with Focal aware cognitive seizure with deja vu/jamais vu?",
    "seeds": [
      "Focal aware cognitive seizure with deja vu/jamais vu"
    ],
    "gold_answer": "Focal aware non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08583",
    "question": "What phenotype is associated with Leukodystrophy, childhood-onset, remitting?",
    "seeds": [
      "Leukodystrophy, childhood-onset, remitting"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08584",
    "question": "What is associated with Olivopontocerebellar atrophy?",
    "seeds": [
      "Olivopontocerebellar atrophy"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08585",
    "question": "What is associated with Class I obesity?",
    "seeds": [
      "Class I obesity"
    ],
    "gold_answer": "Increased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08586",
    "question": "What is associated with Iris nevus?",
    "seeds": [
      "Iris nevus"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08587",
    "question": "What is associated with Hyperemesis gravidarum?",
    "seeds": [
      "Hyperemesis gravidarum"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08588",
    "question": "What is associated with Increased circulating octadecanoate level?",
    "seeds": [
      "Increased circulating octadecanoate level"
    ],
    "gold_answer": "Abnormal circulating long-chain fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08589",
    "question": "What is associated with Spastic paraplegia 12, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 12, autosomal dominant"
    ],
    "gold_answer": "Limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08590",
    "question": "What is associated with Renal medullary pyramid hypoplasia?",
    "seeds": [
      "Renal medullary pyramid hypoplasia"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08591",
    "question": "What phenotype is associated with Retinopathy of prematurity stage 1?",
    "seeds": [
      "Retinopathy of prematurity stage 1"
    ],
    "gold_answer": "Blindness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08592",
    "question": "What is associated with Anomalous origin of left coronary artery from the pulmonary artery?",
    "seeds": [
      "Anomalous origin of left coronary artery from the pulmonary artery"
    ],
    "gold_answer": "Anomalous origin of coronary artery from the pulmonary artery",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08593",
    "question": "What is associated with Abnormal memory B cell proportion?",
    "seeds": [
      "Abnormal memory B cell proportion"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08594",
    "question": "What is associated with Cementum hypoplasia?",
    "seeds": [
      "Cementum hypoplasia"
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08595",
    "question": "What is associated with Alfadhel syndrome?",
    "seeds": [
      "Alfadhel syndrome"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08596",
    "question": "What is associated with Anti-beta fodrin antibody positivity?",
    "seeds": [
      "Anti-beta fodrin antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08597",
    "question": "What is associated with Hordeolum internum?",
    "seeds": [
      "Hordeolum internum"
    ],
    "gold_answer": "Hordeolum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08598",
    "question": "What is associated with Antimitochondrial antibody positivity?",
    "seeds": [
      "Antimitochondrial antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08599",
    "question": "What phenotype is associated with Spastic paraplegia-Paget disease of bone syndrome?",
    "seeds": [
      "Spastic paraplegia-Paget disease of bone syndrome"
    ],
    "gold_answer": "Tongue fasciculations",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08600",
    "question": "What is associated with Ureteric stricture?",
    "seeds": [
      "Ureteric stricture"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08601",
    "question": "What is associated with Myopathy, congenital proximal, with minicore lesions?",
    "seeds": [
      "Myopathy, congenital proximal, with minicore lesions"
    ],
    "gold_answer": "Abnormality of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08602",
    "question": "What phenotype is associated with Distal deletion 3p syndrome?",
    "seeds": [
      "Distal deletion 3p syndrome"
    ],
    "gold_answer": "Abnormal vestibulo-ocular reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08603",
    "question": "What is associated with Cone-shaped epiphysis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Cone-shaped epiphysis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal 3rd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08604",
    "question": "What is associated with Myelocystocele?",
    "seeds": [
      "Myelocystocele"
    ],
    "gold_answer": "Closed neural tube defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08605",
    "question": "What is associated with Decreased specific antibody response to protein-conjugated polysaccharide vaccine?",
    "seeds": [
      "Decreased specific antibody response to protein-conjugated polysaccharide vaccine"
    ],
    "gold_answer": "Decreased circulating level of specific antibody",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08606",
    "question": "What is associated with Decreased total monocyte count?",
    "seeds": [
      "Decreased total monocyte count"
    ],
    "gold_answer": "Abnormal monocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08607",
    "question": "What is associated with Renal tubular karyomegaly?",
    "seeds": [
      "Renal tubular karyomegaly"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08608",
    "question": "What is associated with Uterine rupture?",
    "seeds": [
      "Uterine rupture"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08609",
    "question": "What phenotype is associated with Spermatogenic failure 49?",
    "seeds": [
      "Spermatogenic failure 49"
    ],
    "gold_answer": "Absent sperm flagella",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08610",
    "question": "What is associated with Oculovertebral syndrome?",
    "seeds": [
      "Oculovertebral syndrome"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08611",
    "question": "What is associated with Hypotension?",
    "seeds": [
      "Hypotension"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08612",
    "question": "What is associated with Dyskinesia, seizures, and intellectual developmental disorder?",
    "seeds": [
      "Dyskinesia, seizures, and intellectual developmental disorder"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08613",
    "question": "What is associated with Myxoid liposarcoma?",
    "seeds": [
      "Myxoid liposarcoma"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08614",
    "question": "What is associated with Spermatogenic failure 82?",
    "seeds": [
      "Spermatogenic failure 82"
    ],
    "gold_answer": "Decreased fertility in males",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08615",
    "question": "What is associated with Non-restrictive ventricular septal defect?",
    "seeds": [
      "Non-restrictive ventricular septal defect"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08616",
    "question": "What is associated with Deformed humeral heads?",
    "seeds": [
      "Deformed humeral heads"
    ],
    "gold_answer": "Deformed humerus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08617",
    "question": "What is associated with Polyneuritis?",
    "seeds": [
      "Polyneuritis"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08618",
    "question": "What is associated with Decreased total granulocyte count?",
    "seeds": [
      "Decreased total granulocyte count"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08619",
    "question": "What is associated with Myasthenic syndrome, congenital, 4A, slow-channel?",
    "seeds": [
      "Myasthenic syndrome, congenital, 4A, slow-channel"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08620",
    "question": "What is associated with Bacteria allergy?",
    "seeds": [
      "Bacteria allergy"
    ],
    "gold_answer": "Immunologic hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08621",
    "question": "What phenotype is associated with Schuurs-Hoeijmakers syndrome?",
    "seeds": [
      "Schuurs-Hoeijmakers syndrome"
    ],
    "gold_answer": "Single transverse palmar crease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08622",
    "question": "What is associated with Increased mean corpuscular hemoglobin concentration?",
    "seeds": [
      "Increased mean corpuscular hemoglobin concentration"
    ],
    "gold_answer": "Abnormal mean corpuscular hemoglobin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08623",
    "question": "What is associated with Necrolytic migratory erythema?",
    "seeds": [
      "Necrolytic migratory erythema"
    ],
    "gold_answer": "Erythema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08624",
    "question": "What is associated with Abnormal lymph-node lymphocyte cytoplasm morphology?",
    "seeds": [
      "Abnormal lymph-node lymphocyte cytoplasm morphology"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08625",
    "question": "What is associated with Hyaline casts?",
    "seeds": [
      "Hyaline casts"
    ],
    "gold_answer": "Cylindruria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08626",
    "question": "What phenotype is associated with ICF syndrome?",
    "seeds": [
      "ICF syndrome"
    ],
    "gold_answer": "Umbilical hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08627",
    "question": "What is associated with Pleomorphic xanthoastrocytoma?",
    "seeds": [
      "Pleomorphic xanthoastrocytoma"
    ],
    "gold_answer": "Abnormal astrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08628",
    "question": "What is associated with Hypoketotic hypoglycemia?",
    "seeds": [
      "Hypoketotic hypoglycemia"
    ],
    "gold_answer": "Hypoglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08629",
    "question": "What is associated with Familial cold autoinflammatory syndrome 3?",
    "seeds": [
      "Familial cold autoinflammatory syndrome 3"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08630",
    "question": "What is associated with Direct antiglobulin test positive for IgM?",
    "seeds": [
      "Direct antiglobulin test positive for IgM"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08631",
    "question": "What is associated with Facial palsy?",
    "seeds": [
      "Facial palsy"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08632",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, axonal, type 2W?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2W"
    ],
    "gold_answer": "Absent Achilles reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08633",
    "question": "What is associated with Abnormal skull base morphology?",
    "seeds": [
      "Abnormal skull base morphology"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08634",
    "question": "What phenotype is associated with Pompe disease, late-onset?",
    "seeds": [
      "Pompe disease, late-onset"
    ],
    "gold_answer": "Elevated circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08635",
    "question": "What is associated with Enlarged thalamic volume?",
    "seeds": [
      "Enlarged thalamic volume"
    ],
    "gold_answer": "Abnormal thalamic size",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08636",
    "question": "What is associated with Tropical calcific pancreatitis?",
    "seeds": [
      "Tropical calcific pancreatitis"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08637",
    "question": "What is associated with Total absence of the pericardium?",
    "seeds": [
      "Total absence of the pericardium"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08638",
    "question": "What is associated with Focal aware emotional seizure with paranoia?",
    "seeds": [
      "Focal aware emotional seizure with paranoia"
    ],
    "gold_answer": "Focal aware non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08639",
    "question": "What phenotype is associated with Spinocerebellar ataxia, X-linked 2?",
    "seeds": [
      "Spinocerebellar ataxia, X-linked 2"
    ],
    "gold_answer": "Abnormality of extrapyramidal motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08640",
    "question": "What is associated with Arthrogryposis, distal, type 4?",
    "seeds": [
      "Arthrogryposis, distal, type 4"
    ],
    "gold_answer": "Talipes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08641",
    "question": "What is associated with Progressive familial heart block, type IB?",
    "seeds": [
      "Progressive familial heart block, type IB"
    ],
    "gold_answer": "Reduced consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08642",
    "question": "What phenotype is associated with Rothmund-Thomson syndrome type 1?",
    "seeds": [
      "Rothmund-Thomson syndrome type 1"
    ],
    "gold_answer": "Abnormality of the radial head",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08643",
    "question": "What is associated with Abnormality of the thenar eminence?",
    "seeds": [
      "Abnormality of the thenar eminence"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08644",
    "question": "What is associated with Cerebral germinoma?",
    "seeds": [
      "Cerebral germinoma"
    ],
    "gold_answer": "Neoplasm of the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08645",
    "question": "What is associated with Abnormal fetal genitourinary system morphology?",
    "seeds": [
      "Abnormal fetal genitourinary system morphology"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08646",
    "question": "What is associated with Abnormal lens capsule morphology?",
    "seeds": [
      "Abnormal lens capsule morphology"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08647",
    "question": "What is associated with Li-Campeau syndrome?",
    "seeds": [
      "Li-Campeau syndrome"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08648",
    "question": "What is associated with Prominent tragus?",
    "seeds": [
      "Prominent tragus"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08649",
    "question": "What phenotype is associated with SCHIZENCEPHALY?",
    "seeds": [
      "SCHIZENCEPHALY"
    ],
    "gold_answer": "Agenesis of corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08650",
    "question": "What is associated with Renal intimal/medial arteriolitis?",
    "seeds": [
      "Renal intimal/medial arteriolitis"
    ],
    "gold_answer": "Abnormal renal arteriole morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08651",
    "question": "What is associated with Broad proximal phalanx of the thumb?",
    "seeds": [
      "Broad proximal phalanx of the thumb"
    ],
    "gold_answer": "Abnormal middle phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08652",
    "question": "What is associated with Aneurysm, intracranial berry, 1?",
    "seeds": [
      "Aneurysm, intracranial berry, 1"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08653",
    "question": "What phenotype is associated with Camptodactyly-joint contractures-facial skeletal defects syndrome?",
    "seeds": [
      "Camptodactyly-joint contractures-facial skeletal defects syndrome"
    ],
    "gold_answer": "Abnormality of the hip bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08654",
    "question": "What is associated with Scalloped appearance of liver surface?",
    "seeds": [
      "Scalloped appearance of liver surface"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08655",
    "question": "What phenotype is associated with 17q24.2 microdeletion syndrome?",
    "seeds": [
      "17q24.2 microdeletion syndrome"
    ],
    "gold_answer": "Median cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08656",
    "question": "What is associated with Retrocollis?",
    "seeds": [
      "Retrocollis"
    ],
    "gold_answer": "Abnormal morphology of the musculature of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08657",
    "question": "What phenotype is associated with Hereditary bullous dystrophy, macular type?",
    "seeds": [
      "Hereditary bullous dystrophy, macular type"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08658",
    "question": "What is associated with Abnormal B cell physiology?",
    "seeds": [
      "Abnormal B cell physiology"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08659",
    "question": "What is associated with Focal segmental glomerulosclerosis 10?",
    "seeds": [
      "Focal segmental glomerulosclerosis 10"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08660",
    "question": "What is associated with Decreased CSF lysine concentration?",
    "seeds": [
      "Decreased CSF lysine concentration"
    ],
    "gold_answer": "Abnormal CSF aspartate family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08661",
    "question": "What phenotype is associated with Immune-mediated necrotizing myopathy?",
    "seeds": [
      "Immune-mediated necrotizing myopathy"
    ],
    "gold_answer": "Elevated circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08662",
    "question": "What is associated with Pelizaeus-Merzbacher-like disease due to HSPD1 mutation?",
    "seeds": [
      "Pelizaeus-Merzbacher-like disease due to HSPD1 mutation"
    ],
    "gold_answer": "HSPD1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08663",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 13?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 13"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08664",
    "question": "What is associated with Vestibular nystagmus?",
    "seeds": [
      "Vestibular nystagmus"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08665",
    "question": "What is associated with Hyperkinetic movements?",
    "seeds": [
      "Hyperkinetic movements"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08666",
    "question": "What phenotype is associated with Complement component 4B deficiency?",
    "seeds": [
      "Complement component 4B deficiency"
    ],
    "gold_answer": "Meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08667",
    "question": "What is associated with Testicular tumor, somatic?",
    "seeds": [
      "Testicular tumor, somatic"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08668",
    "question": "What is associated with Gastric pseudomass?",
    "seeds": [
      "Gastric pseudomass"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08669",
    "question": "What is associated with Patchy sclerosis of 3rd finger phalanx?",
    "seeds": [
      "Patchy sclerosis of 3rd finger phalanx"
    ],
    "gold_answer": "Abnormal 3rd finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08670",
    "question": "What is associated with Paracentral hyper-autofluorecence?",
    "seeds": [
      "Paracentral hyper-autofluorecence"
    ],
    "gold_answer": "Abnormal posterior segment imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08671",
    "question": "What is associated with Periorbital hyperpigmentation?",
    "seeds": [
      "Periorbital hyperpigmentation"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08672",
    "question": "What is associated with Motion sickness?",
    "seeds": [
      "Motion sickness"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08673",
    "question": "What is associated with Hypermethioninemia due to glycine N-methyltransferase deficiency?",
    "seeds": [
      "Hypermethioninemia due to glycine N-methyltransferase deficiency"
    ],
    "gold_answer": "GNMT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_08674",
    "question": "What is associated with Exacerbated by tobacco use?",
    "seeds": [
      "Exacerbated by tobacco use"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08675",
    "question": "What is associated with Woolly scalp hair?",
    "seeds": [
      "Woolly scalp hair"
    ],
    "gold_answer": "Abnormality of hair texture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08676",
    "question": "What is associated with Arrhythmogenic right ventricular dysplasia 1?",
    "seeds": [
      "Arrhythmogenic right ventricular dysplasia 1"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08677",
    "question": "What is associated with Abnormal heart valve physiology?",
    "seeds": [
      "Abnormal heart valve physiology"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08678",
    "question": "What is associated with Exudative pleural effusion?",
    "seeds": [
      "Exudative pleural effusion"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08679",
    "question": "What is associated with Restrictive external ophthalmoplegia?",
    "seeds": [
      "Restrictive external ophthalmoplegia"
    ],
    "gold_answer": "Ophthalmoplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08680",
    "question": "What is associated with Loss of gluteal subcutaneous adipose tissue?",
    "seeds": [
      "Loss of gluteal subcutaneous adipose tissue"
    ],
    "gold_answer": "Adipose tissue loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08681",
    "question": "What is associated with Atypical Rett syndrome?",
    "seeds": [
      "Atypical Rett syndrome"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08682",
    "question": "What is associated with Metaphyseal striations?",
    "seeds": [
      "Metaphyseal striations"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08683",
    "question": "What is associated with Transthyretin amyloid deposition?",
    "seeds": [
      "Transthyretin amyloid deposition"
    ],
    "gold_answer": "Amyloid deposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08684",
    "question": "What is associated with Abnormal dental morphology?",
    "seeds": [
      "Abnormal dental morphology"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08685",
    "question": "What is associated with Abnormal knee physiology?",
    "seeds": [
      "Abnormal knee physiology"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08686",
    "question": "What is associated with Small epiphysis of the proximal phalanx of the 3rd toe?",
    "seeds": [
      "Small epiphysis of the proximal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08687",
    "question": "What is associated with Dyscalculia?",
    "seeds": [
      "Dyscalculia"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08688",
    "question": "What is associated with Abnormal circulating adrenocorticotropin concentration?",
    "seeds": [
      "Abnormal circulating adrenocorticotropin concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08689",
    "question": "What is associated with Oculocerebrofacial syndrome, Kaufman type?",
    "seeds": [
      "Oculocerebrofacial syndrome, Kaufman type"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08690",
    "question": "What is associated with Short toe?",
    "seeds": [
      "Short toe"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08691",
    "question": "What is associated with Uninodular goiter?",
    "seeds": [
      "Uninodular goiter"
    ],
    "gold_answer": "Nodular goiter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08692",
    "question": "What is associated with Waardenburg syndrome, type 4B?",
    "seeds": [
      "Waardenburg syndrome, type 4B"
    ],
    "gold_answer": "Megacolon",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08693",
    "question": "What is associated with Chromosome 10q26 deletion syndrome?",
    "seeds": [
      "Chromosome 10q26 deletion syndrome"
    ],
    "gold_answer": "Deviation of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08694",
    "question": "What is associated with Iron overload, susceptibility to?",
    "seeds": [
      "Iron overload, susceptibility to"
    ],
    "gold_answer": "Abnormal hepatic iron concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08695",
    "question": "What is associated with Hemolacria?",
    "seeds": [
      "Hemolacria"
    ],
    "gold_answer": "Lacrimation abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08696",
    "question": "What is associated with CSF polymorphonuclear pleocytosis?",
    "seeds": [
      "CSF polymorphonuclear pleocytosis"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08697",
    "question": "What is associated with Sparse or absent eyelashes?",
    "seeds": [
      "Sparse or absent eyelashes"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08698",
    "question": "What is associated with Intrauterine fetal demise of one twin after midgestation?",
    "seeds": [
      "Intrauterine fetal demise of one twin after midgestation"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08699",
    "question": "What is associated with Pelvic bone exostoses?",
    "seeds": [
      "Pelvic bone exostoses"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08700",
    "question": "What phenotype is associated with X-linked intellectual disability, Snyder type?",
    "seeds": [
      "X-linked intellectual disability, Snyder type"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08701",
    "question": "What is associated with Bowman capsular hyaline drops?",
    "seeds": [
      "Bowman capsular hyaline drops"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08702",
    "question": "What is associated with Abnormality of the pancreas?",
    "seeds": [
      "Abnormality of the pancreas"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08703",
    "question": "What is associated with Absent epiphysis of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Absent epiphysis of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Absent epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08704",
    "question": "What phenotype is associated with Neuronopathy, distal hereditary motor, autosomal dominant 15?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, autosomal dominant 15"
    ],
    "gold_answer": "Fiber type grouping",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08705",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 26?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 26"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08706",
    "question": "What is associated with Autosomal dominant hypocalcemia?",
    "seeds": [
      "Autosomal dominant hypocalcemia"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08707",
    "question": "What is associated with Severe recurrent varicella?",
    "seeds": [
      "Severe recurrent varicella"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08708",
    "question": "What is associated with Elevated erythrocyte AICA-ribotide concentration?",
    "seeds": [
      "Elevated erythrocyte AICA-ribotide concentration"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08709",
    "question": "What is associated with Achondrogenesis, type II?",
    "seeds": [
      "Achondrogenesis, type II"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08710",
    "question": "What is associated with Abnormal antihelix morphology?",
    "seeds": [
      "Abnormal antihelix morphology"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08711",
    "question": "What phenotype is associated with Osteopetrosis, autosomal dominant 1?",
    "seeds": [
      "Osteopetrosis, autosomal dominant 1"
    ],
    "gold_answer": "Mandibular pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08712",
    "question": "What is associated with Thyroid nodule?",
    "seeds": [
      "Thyroid nodule"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08713",
    "question": "What phenotype is associated with Glucocorticoid deficiency 4 with or without mineralocorticoid deficiency?",
    "seeds": [
      "Glucocorticoid deficiency 4 with or without mineralocorticoid deficiency"
    ],
    "gold_answer": "Failure to thrive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08714",
    "question": "What is associated with Orbital craniosynostosis?",
    "seeds": [
      "Orbital craniosynostosis"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08715",
    "question": "What is associated with Spastic paraplegia 90B, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 90B, autosomal recessive"
    ],
    "gold_answer": "Excessive salivation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08716",
    "question": "What is associated with Lower limb amyotrophy?",
    "seeds": [
      "Lower limb amyotrophy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08717",
    "question": "What is associated with Temporal bossing?",
    "seeds": [
      "Temporal bossing"
    ],
    "gold_answer": "Abnormal temporal bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08718",
    "question": "What is associated with Abnormality of the epiphyses of the distal phalanx of finger?",
    "seeds": [
      "Abnormality of the epiphyses of the distal phalanx of finger"
    ],
    "gold_answer": "Abnormal distal phalanx morphology of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08719",
    "question": "What is associated with Hypoprolinemia?",
    "seeds": [
      "Hypoprolinemia"
    ],
    "gold_answer": "Abnormal circulating glutamine family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08720",
    "question": "What is associated with Elevated circulating alpha-ketoglutarate concentration?",
    "seeds": [
      "Elevated circulating alpha-ketoglutarate concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08721",
    "question": "What is associated with Minor finding?",
    "seeds": [
      "Minor finding"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08722",
    "question": "What is associated with CSF infectious agent?",
    "seeds": [
      "CSF infectious agent"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08723",
    "question": "What is associated with Blepharospasm?",
    "seeds": [
      "Blepharospasm"
    ],
    "gold_answer": "Craniofacial dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08724",
    "question": "What is associated with Atypical sorting?",
    "seeds": [
      "Atypical sorting"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08725",
    "question": "What is associated with Decreased fumarate hydratase activity?",
    "seeds": [
      "Decreased fumarate hydratase activity"
    ],
    "gold_answer": "Abnormality of Krebs cycle metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08726",
    "question": "What is associated with Duplication of the distal phalanx of the 4th finger?",
    "seeds": [
      "Duplication of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08727",
    "question": "What is associated with Cerebral cortex with spongiform changes?",
    "seeds": [
      "Cerebral cortex with spongiform changes"
    ],
    "gold_answer": "Abnormal cerebral cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08728",
    "question": "What is associated with Focal aware cognitive seizure with neglect?",
    "seeds": [
      "Focal aware cognitive seizure with neglect"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08729",
    "question": "What is associated with Focal aware tonic seizure?",
    "seeds": [
      "Focal aware tonic seizure"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08730",
    "question": "What is associated with Lobular carcinoma in situ?",
    "seeds": [
      "Lobular carcinoma in situ"
    ],
    "gold_answer": "Abnormality of the breast",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08731",
    "question": "What is associated with Thin upper lip vermilion?",
    "seeds": [
      "Thin upper lip vermilion"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08732",
    "question": "What is associated with Total anosmia?",
    "seeds": [
      "Total anosmia"
    ],
    "gold_answer": "Anosmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08733",
    "question": "What is associated with Duodenal atrophy?",
    "seeds": [
      "Duodenal atrophy"
    ],
    "gold_answer": "Abnormal small intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08734",
    "question": "What is associated with Microscopic polyangiitis?",
    "seeds": [
      "Microscopic polyangiitis"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08735",
    "question": "What is associated with Neuralgia?",
    "seeds": [
      "Neuralgia"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08736",
    "question": "What is associated with Metaphyseal chondromatosis of radius?",
    "seeds": [
      "Metaphyseal chondromatosis of radius"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08737",
    "question": "What is associated with Lower extremity peripheral arterial calcification?",
    "seeds": [
      "Lower extremity peripheral arterial calcification"
    ],
    "gold_answer": "Peripheral arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08738",
    "question": "What is associated with Large sternal ossification centers?",
    "seeds": [
      "Large sternal ossification centers"
    ],
    "gold_answer": "Abnormal sternal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08739",
    "question": "What phenotype is associated with Glycerol kinase deficiency?",
    "seeds": [
      "Glycerol kinase deficiency"
    ],
    "gold_answer": "Increased circulating lactate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08740",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the thumb?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Patchy osteosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08741",
    "question": "What is associated with Hypoplastic distal radial epiphyses?",
    "seeds": [
      "Hypoplastic distal radial epiphyses"
    ],
    "gold_answer": "Abnormal radial epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08742",
    "question": "What phenotype is associated with Anauxetic dysplasia 1?",
    "seeds": [
      "Anauxetic dysplasia 1"
    ],
    "gold_answer": "Flared metaphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08743",
    "question": "What is associated with EEG with temporal slowing?",
    "seeds": [
      "EEG with temporal slowing"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08744",
    "question": "What is associated with Cardiac conduction disease with or without cardiomyopathy 2?",
    "seeds": [
      "Cardiac conduction disease with or without cardiomyopathy 2"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08745",
    "question": "What is associated with Focal epithelial hyperplasia of oral mucosa?",
    "seeds": [
      "Focal epithelial hyperplasia of oral mucosa"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08746",
    "question": "What is associated with Developmental delay-immunodeficiency-leukoencephalopathy-hypohomocysteinemia syndrome?",
    "seeds": [
      "Developmental delay-immunodeficiency-leukoencephalopathy-hypohomocysteinemia syndrome"
    ],
    "gold_answer": "NFE2L2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08747",
    "question": "What is associated with Abnormality of the epiphysis of the proximal phalanx of the 3rd toe?",
    "seeds": [
      "Abnormality of the epiphysis of the proximal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal third toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08748",
    "question": "What is associated with Deafness, autosomal recessive 93?",
    "seeds": [
      "Deafness, autosomal recessive 93"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08749",
    "question": "What is associated with Cupped radial metaphyses?",
    "seeds": [
      "Cupped radial metaphyses"
    ],
    "gold_answer": "Metaphyseal cupping",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08750",
    "question": "What is associated with Atrial fibrillation, familial, 11?",
    "seeds": [
      "Atrial fibrillation, familial, 11"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08751",
    "question": "What is associated with Meconium aspiration syndrome?",
    "seeds": [
      "Meconium aspiration syndrome"
    ],
    "gold_answer": "Abnormal blood gas level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08752",
    "question": "What is associated with Bulging epiphyses?",
    "seeds": [
      "Bulging epiphyses"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08753",
    "question": "What is associated with Gait instability, worse in the dark?",
    "seeds": [
      "Gait instability, worse in the dark"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08754",
    "question": "What phenotype is associated with Myoclonic epilepsy of Lafora 2?",
    "seeds": [
      "Myoclonic epilepsy of Lafora 2"
    ],
    "gold_answer": "Progressive neurologic deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08755",
    "question": "What is associated with Medium chain acyl-CoA dehydrogenase deficiency?",
    "seeds": [
      "Medium chain acyl-CoA dehydrogenase deficiency"
    ],
    "gold_answer": "Seizure precipitated by febrile infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08756",
    "question": "What is associated with Abnormal muscle fiber morphology?",
    "seeds": [
      "Abnormal muscle fiber morphology"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08757",
    "question": "What is associated with Permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome?",
    "seeds": [
      "Permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08758",
    "question": "What phenotype is associated with Young syndrome?",
    "seeds": [
      "Young syndrome"
    ],
    "gold_answer": "Reduced forced vital capacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08759",
    "question": "What is associated with Reduced tissue gamma-glutamyltransferase activity?",
    "seeds": [
      "Reduced tissue gamma-glutamyltransferase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08760",
    "question": "What is associated with Abnormal elbow epiphysis morphology?",
    "seeds": [
      "Abnormal elbow epiphysis morphology"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08761",
    "question": "What is associated with Bifid nail?",
    "seeds": [
      "Bifid nail"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08762",
    "question": "What phenotype is associated with Multiple congenital anomalies-neurodevelopmental syndrome, X-linked?",
    "seeds": [
      "Multiple congenital anomalies-neurodevelopmental syndrome, X-linked"
    ],
    "gold_answer": "Talipes equinovarus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08763",
    "question": "What is associated with X-linked inheritance?",
    "seeds": [
      "X-linked inheritance"
    ],
    "gold_answer": "Mendelian inheritance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08764",
    "question": "What is associated with Enlarged proximal interphalangeal joints?",
    "seeds": [
      "Enlarged proximal interphalangeal joints"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08765",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 38?",
    "seeds": [
      "Ciliary dyskinesia, primary, 38"
    ],
    "gold_answer": "Intestinal malrotation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08766",
    "question": "What is associated with Reduced blood folate concentration?",
    "seeds": [
      "Reduced blood folate concentration"
    ],
    "gold_answer": "Abnormality of folate metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08767",
    "question": "What is associated with Nephrotic syndrome, type 26?",
    "seeds": [
      "Nephrotic syndrome, type 26"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08768",
    "question": "What is associated with Renal cyst?",
    "seeds": [
      "Renal cyst"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08769",
    "question": "What is associated with Schwannomatosis?",
    "seeds": [
      "Schwannomatosis"
    ],
    "gold_answer": "Neoplasm of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08770",
    "question": "What phenotype is associated with Leukocyte nuclear appendages, hereditary prevalence of?",
    "seeds": [
      "Leukocyte nuclear appendages, hereditary prevalence of"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08771",
    "question": "What is associated with Absent Bell phenomenon?",
    "seeds": [
      "Absent Bell phenomenon"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08772",
    "question": "What is associated with Bracket epiphyses of the middle phalanges of the hand?",
    "seeds": [
      "Bracket epiphyses of the middle phalanges of the hand"
    ],
    "gold_answer": "Abnormal middle phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08773",
    "question": "What is associated with Abnormal pancreatic duct morphology?",
    "seeds": [
      "Abnormal pancreatic duct morphology"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08774",
    "question": "What is associated with Iridescent posterior subcapsular cataract?",
    "seeds": [
      "Iridescent posterior subcapsular cataract"
    ],
    "gold_answer": "Posterior subcapsular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08775",
    "question": "What is associated with Recurrent fungal infections?",
    "seeds": [
      "Recurrent fungal infections"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08776",
    "question": "What is associated with Abnormal finger phalanx morphology?",
    "seeds": [
      "Abnormal finger phalanx morphology"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08777",
    "question": "What is associated with Abnormal paranasal sinus morphology?",
    "seeds": [
      "Abnormal paranasal sinus morphology"
    ],
    "gold_answer": "Abnormality of the upper respiratory tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08778",
    "question": "What is associated with Hyperpigmented papule?",
    "seeds": [
      "Hyperpigmented papule"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08779",
    "question": "What is associated with Decreased circulating mannose-binding protein concentration?",
    "seeds": [
      "Decreased circulating mannose-binding protein concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08780",
    "question": "What is associated with Osteolytic defects of the middle phalanx of the 2nd toe?",
    "seeds": [
      "Osteolytic defects of the middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Osteolysis involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08781",
    "question": "What phenotype is associated with Pallister-Hall syndrome?",
    "seeds": [
      "Pallister-Hall syndrome"
    ],
    "gold_answer": "Intestinal malrotation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08782",
    "question": "What is associated with Developmental and epileptic encephalopathy 48?",
    "seeds": [
      "Developmental and epileptic encephalopathy 48"
    ],
    "gold_answer": "Abnormal eye contact",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08783",
    "question": "What phenotype is associated with Neurodevelopmental disorder with seizures and gingival overgrowth?",
    "seeds": [
      "Neurodevelopmental disorder with seizures and gingival overgrowth"
    ],
    "gold_answer": "Slurred speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08784",
    "question": "What is associated with Adenocarcinoma of the small intestine?",
    "seeds": [
      "Adenocarcinoma of the small intestine"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08785",
    "question": "What is associated with Ectrodactyly-polydactyly syndrome?",
    "seeds": [
      "Ectrodactyly-polydactyly syndrome"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08786",
    "question": "What phenotype is associated with Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4?",
    "seeds": [
      "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4"
    ],
    "gold_answer": "Corpus callosum atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08787",
    "question": "What is associated with Delusion of love?",
    "seeds": [
      "Delusion of love"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08788",
    "question": "What is associated with Hereditary myopathy with early respiratory failure?",
    "seeds": [
      "Hereditary myopathy with early respiratory failure"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08789",
    "question": "What is associated with Epiphyseal dysplasia, multiple, with myopia and conductive deafness?",
    "seeds": [
      "Epiphyseal dysplasia, multiple, with myopia and conductive deafness"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08790",
    "question": "What is associated with Exostoses of the ulna?",
    "seeds": [
      "Exostoses of the ulna"
    ],
    "gold_answer": "Exostoses of the forearm bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08791",
    "question": "What is associated with DUODENAL ULCER DUE TO ANTRAL G-CELL HYPERFUNCTION?",
    "seeds": [
      "DUODENAL ULCER DUE TO ANTRAL G-CELL HYPERFUNCTION"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08792",
    "question": "What is associated with Left Isomerism?",
    "seeds": [
      "Left Isomerism"
    ],
    "gold_answer": "Heterotaxy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08793",
    "question": "What is associated with Bleeding into skin lesions?",
    "seeds": [
      "Bleeding into skin lesions"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08794",
    "question": "What is associated with Pleural mass?",
    "seeds": [
      "Pleural mass"
    ],
    "gold_answer": "Mass on thoracic imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08795",
    "question": "What is associated with Maxillonasal dysplasia, Binder type?",
    "seeds": [
      "Maxillonasal dysplasia, Binder type"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08796",
    "question": "What is associated with Multiflagellar spermatozoa?",
    "seeds": [
      "Multiflagellar spermatozoa"
    ],
    "gold_answer": "Abnormal sperm tail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08797",
    "question": "What is associated with Prekallikrein deficiency?",
    "seeds": [
      "Prekallikrein deficiency"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08798",
    "question": "What is associated with Focal impaired awareness hemifacial clonic seizure?",
    "seeds": [
      "Focal impaired awareness hemifacial clonic seizure"
    ],
    "gold_answer": "Clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08799",
    "question": "What is associated with Insulin-Like growth factor I, resistance to?",
    "seeds": [
      "Insulin-Like growth factor I, resistance to"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08800",
    "question": "What phenotype is associated with Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay?",
    "seeds": [
      "Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay"
    ],
    "gold_answer": "Myoclonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08801",
    "question": "What is associated with Autoinflammation with infantile enterocolitis?",
    "seeds": [
      "Autoinflammation with infantile enterocolitis"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08802",
    "question": "What is associated with Freckled genitalia?",
    "seeds": [
      "Freckled genitalia"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08803",
    "question": "What is associated with Decreased skull base length?",
    "seeds": [
      "Decreased skull base length"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08804",
    "question": "What is associated with Ivory epiphysis of the proximal phalanx of the thumb?",
    "seeds": [
      "Ivory epiphysis of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Abnormality of the epiphyses of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08805",
    "question": "What is associated with Phosphoglycerate mutase, muscle, deficiency of?",
    "seeds": [
      "Phosphoglycerate mutase, muscle, deficiency of"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08806",
    "question": "What is associated with Decreased circulating beta-mannosidase activity?",
    "seeds": [
      "Decreased circulating beta-mannosidase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08807",
    "question": "What is associated with Aplasia/Hypoplasia of the brainstem?",
    "seeds": [
      "Aplasia/Hypoplasia of the brainstem"
    ],
    "gold_answer": "Abnormal brainstem morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08808",
    "question": "What is associated with Proximal placement of hallux?",
    "seeds": [
      "Proximal placement of hallux"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08809",
    "question": "What is associated with Abnormal CSF urate concentration?",
    "seeds": [
      "Abnormal CSF urate concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08810",
    "question": "What is associated with Follicular lymphoma?",
    "seeds": [
      "Follicular lymphoma"
    ],
    "gold_answer": "HLA-DRB1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_08811",
    "question": "What is associated with Autoimmunity?",
    "seeds": [
      "Autoimmunity"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08812",
    "question": "What phenotype is associated with Distal 7q11.23 microdeletion syndrome?",
    "seeds": [
      "Distal 7q11.23 microdeletion syndrome"
    ],
    "gold_answer": "Attention deficit hyperactivity disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08813",
    "question": "What is associated with DEFECTIVE INTERFERING PARTICLE INDUCTION, CONTROL OF?",
    "seeds": [
      "DEFECTIVE INTERFERING PARTICLE INDUCTION, CONTROL OF"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08814",
    "question": "What is associated with Abnormal lower-limb metaphysis morphology?",
    "seeds": [
      "Abnormal lower-limb metaphysis morphology"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08815",
    "question": "What is associated with Anti-contactin-associated protein 1 antibody positivity?",
    "seeds": [
      "Anti-contactin-associated protein 1 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08816",
    "question": "What is associated with Paraspinal neurofibroma?",
    "seeds": [
      "Paraspinal neurofibroma"
    ],
    "gold_answer": "Neurofibroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08817",
    "question": "What is associated with Craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 2?",
    "seeds": [
      "Craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 2"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08818",
    "question": "What phenotype is associated with Hypothyroidism, congenital, nongoitrous, 1?",
    "seeds": [
      "Hypothyroidism, congenital, nongoitrous, 1"
    ],
    "gold_answer": "Jaundice",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08819",
    "question": "What phenotype is associated with 46XY sex reversal 5?",
    "seeds": [
      "46XY sex reversal 5"
    ],
    "gold_answer": "Sex reversal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08820",
    "question": "What is associated with Carotid sinus syncope?",
    "seeds": [
      "Carotid sinus syncope"
    ],
    "gold_answer": "Reduced consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08821",
    "question": "What is associated with Cataract 3, multiple types?",
    "seeds": [
      "Cataract 3, multiple types"
    ],
    "gold_answer": "CRYBB1",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08822",
    "question": "What is associated with Mandibular cyst?",
    "seeds": [
      "Mandibular cyst"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08823",
    "question": "What phenotype is associated with Drug metabolism, altered, CES1-related?",
    "seeds": [
      "Drug metabolism, altered, CES1-related"
    ],
    "gold_answer": "Abnormal drug response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08824",
    "question": "What is associated with Abnormal high-mannose N-glycan level?",
    "seeds": [
      "Abnormal high-mannose N-glycan level"
    ],
    "gold_answer": "Abnormal protein N-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08825",
    "question": "What is associated with Clavicular pseudarthrosis?",
    "seeds": [
      "Clavicular pseudarthrosis"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08826",
    "question": "What is associated with Bone marrow maturation arrest?",
    "seeds": [
      "Bone marrow maturation arrest"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08827",
    "question": "What is associated with Deafness, autosomal recessive 55?",
    "seeds": [
      "Deafness, autosomal recessive 55"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08828",
    "question": "What is associated with Convulsive disorder, familial, with prenatal or early onset?",
    "seeds": [
      "Convulsive disorder, familial, with prenatal or early onset"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08829",
    "question": "What is associated with Rickets?",
    "seeds": [
      "Rickets"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08830",
    "question": "What is associated with White appearance of duodenal mucosa?",
    "seeds": [
      "White appearance of duodenal mucosa"
    ],
    "gold_answer": "Abnormal duodenum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08831",
    "question": "What is associated with 7p22.1 microduplication syndrome?",
    "seeds": [
      "7p22.1 microduplication syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08832",
    "question": "What is associated with Fetal tetracycline exposure?",
    "seeds": [
      "Fetal tetracycline exposure"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08833",
    "question": "What is associated with Anti-tyrosine phosphatase region of islet antigen-2 antibody positivity?",
    "seeds": [
      "Anti-tyrosine phosphatase region of islet antigen-2 antibody positivity"
    ],
    "gold_answer": "Anti-islet antigen-2 antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08834",
    "question": "What is associated with Increased CSF uracil concentration?",
    "seeds": [
      "Increased CSF uracil concentration"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08835",
    "question": "What is associated with Humeral pseudarthrosis?",
    "seeds": [
      "Humeral pseudarthrosis"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08836",
    "question": "What is associated with Hyperinsulinism due to HNF1A deficiency?",
    "seeds": [
      "Hyperinsulinism due to HNF1A deficiency"
    ],
    "gold_answer": "Abnormal eating behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08837",
    "question": "What is associated with Lower limb amyotrophy?",
    "seeds": [
      "Lower limb amyotrophy"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08838",
    "question": "What is associated with Maternal teratogenic exposure?",
    "seeds": [
      "Maternal teratogenic exposure"
    ],
    "gold_answer": "Pregnancy exposure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08839",
    "question": "What is associated with Decreased proportion of HLA DR+ CD4+ T cells?",
    "seeds": [
      "Decreased proportion of HLA DR+ CD4+ T cells"
    ],
    "gold_answer": "Abnormal CD4+ T cell subset proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08840",
    "question": "What is associated with Carpometacarpal thumb joint contracture?",
    "seeds": [
      "Carpometacarpal thumb joint contracture"
    ],
    "gold_answer": "Thumb contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08841",
    "question": "What is associated with Prolonged N1 sleep?",
    "seeds": [
      "Prolonged N1 sleep"
    ],
    "gold_answer": "Abnormal sleep architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08842",
    "question": "What is associated with Pulmonary pneumatocele?",
    "seeds": [
      "Pulmonary pneumatocele"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08843",
    "question": "What phenotype is associated with Infundibulopelvic dysgenesis?",
    "seeds": [
      "Infundibulopelvic dysgenesis"
    ],
    "gold_answer": "Abdominal pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08844",
    "question": "What is associated with Pancreatic fibrosis?",
    "seeds": [
      "Pancreatic fibrosis"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08845",
    "question": "What is associated with Central nervous system cyst?",
    "seeds": [
      "Central nervous system cyst"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08846",
    "question": "What is associated with Visual snow syndrome?",
    "seeds": [
      "Visual snow syndrome"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08847",
    "question": "What is associated with Intellectual developmental disorder, X-linked syndromic, Billuart type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic, Billuart type"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08848",
    "question": "What phenotype is associated with Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay?",
    "seeds": [
      "Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay"
    ],
    "gold_answer": "Mask-like facies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08849",
    "question": "What phenotype is associated with Microphthalmia, isolated, with coloboma 9?",
    "seeds": [
      "Microphthalmia, isolated, with coloboma 9"
    ],
    "gold_answer": "Narrow palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08850",
    "question": "What is associated with Acute constipation?",
    "seeds": [
      "Acute constipation"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08851",
    "question": "What phenotype is associated with Crimean-Congo hemorrhagic fever?",
    "seeds": [
      "Crimean-Congo hemorrhagic fever"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08852",
    "question": "What is associated with Lytic defects of radial diaphysis?",
    "seeds": [
      "Lytic defects of radial diaphysis"
    ],
    "gold_answer": "Abnormal morphology of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08853",
    "question": "What is associated with Abnormal interest?",
    "seeds": [
      "Abnormal interest"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08854",
    "question": "What is associated with Hartnup disorder?",
    "seeds": [
      "Hartnup disorder"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08855",
    "question": "What is associated with Penis uncircumcised?",
    "seeds": [
      "Penis uncircumcised"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08856",
    "question": "What is associated with Amyloid goiter?",
    "seeds": [
      "Amyloid goiter"
    ],
    "gold_answer": "Goiter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08857",
    "question": "What is associated with Abnormality of the incisor?",
    "seeds": [
      "Abnormality of the incisor"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08858",
    "question": "What is associated with Barking cough?",
    "seeds": [
      "Barking cough"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08859",
    "question": "What is associated with Macular pseudocoloboma?",
    "seeds": [
      "Macular pseudocoloboma"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08860",
    "question": "What is associated with Oculoauricular syndrome, Schorderet type?",
    "seeds": [
      "Oculoauricular syndrome, Schorderet type"
    ],
    "gold_answer": "HMX1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_08861",
    "question": "What is associated with Focal autonomic seizure with piloerection?",
    "seeds": [
      "Focal autonomic seizure with piloerection"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08862",
    "question": "What is associated with Succinic acidemia?",
    "seeds": [
      "Succinic acidemia"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08863",
    "question": "What is associated with Bladder polyp?",
    "seeds": [
      "Bladder polyp"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08864",
    "question": "What is associated with Hereditary geniospasm?",
    "seeds": [
      "Hereditary geniospasm"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08865",
    "question": "What phenotype is associated with Familial digital arthropathy-brachydactyly?",
    "seeds": [
      "Familial digital arthropathy-brachydactyly"
    ],
    "gold_answer": "Shortening of all middle phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08866",
    "question": "What is associated with Cervical C6/C7 vertebrae fusion?",
    "seeds": [
      "Cervical C6/C7 vertebrae fusion"
    ],
    "gold_answer": "Vertebral fusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08867",
    "question": "What is associated with Limited vertical extraocular movement?",
    "seeds": [
      "Limited vertical extraocular movement"
    ],
    "gold_answer": "Limited extraocular movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08868",
    "question": "What is associated with Underdeveloped superior crus of antihelix?",
    "seeds": [
      "Underdeveloped superior crus of antihelix"
    ],
    "gold_answer": "Abnormal antihelix morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08869",
    "question": "What is associated with Dilatation of the bladder?",
    "seeds": [
      "Dilatation of the bladder"
    ],
    "gold_answer": "Abnormal bladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08870",
    "question": "What is associated with Abnormal 5th finger morphology?",
    "seeds": [
      "Abnormal 5th finger morphology"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08871",
    "question": "What is associated with Reduced erythrocyte glutathione peroxidase?",
    "seeds": [
      "Reduced erythrocyte glutathione peroxidase"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08872",
    "question": "What is associated with Oppenheim reflex?",
    "seeds": [
      "Oppenheim reflex"
    ],
    "gold_answer": "Long-tract sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08873",
    "question": "What is associated with Ivory epiphyses of the 3rd toe?",
    "seeds": [
      "Ivory epiphyses of the 3rd toe"
    ],
    "gold_answer": "Ivory epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08874",
    "question": "What is associated with Ciliary dyskinesia, primary, 45?",
    "seeds": [
      "Ciliary dyskinesia, primary, 45"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08875",
    "question": "What is associated with Abnormality of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Abnormality of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormal 2nd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08876",
    "question": "What is associated with Elevated CSF myelin basic protein concentration?",
    "seeds": [
      "Elevated CSF myelin basic protein concentration"
    ],
    "gold_answer": "Abnormal CSF protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08877",
    "question": "What is associated with Renal tubular viral cytopathic changes?",
    "seeds": [
      "Renal tubular viral cytopathic changes"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08878",
    "question": "What is associated with Streak ovary?",
    "seeds": [
      "Streak ovary"
    ],
    "gold_answer": "Hypoplasia of the ovary",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08879",
    "question": "What is associated with B Acute Lymphoblastic Leukemia?",
    "seeds": [
      "B Acute Lymphoblastic Leukemia"
    ],
    "gold_answer": "Acute lymphoblastic leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08880",
    "question": "What is associated with Neurodevelopmental disorder with language impairment and behavioral abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with language impairment and behavioral abnormalities"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08881",
    "question": "What is associated with Pituitary hormone deficiency, combined, 2?",
    "seeds": [
      "Pituitary hormone deficiency, combined, 2"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08882",
    "question": "What is associated with IMAGe syndrome?",
    "seeds": [
      "IMAGe syndrome"
    ],
    "gold_answer": "Abnormal adrenal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08883",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type IIO?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIO"
    ],
    "gold_answer": "Decreased circulating ceruloplasmin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08884",
    "question": "What is associated with Abnormal metabolism?",
    "seeds": [
      "Abnormal metabolism"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08885",
    "question": "What phenotype is associated with Trichohepatoneurodevelopmental syndrome?",
    "seeds": [
      "Trichohepatoneurodevelopmental syndrome"
    ],
    "gold_answer": "Curly hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08886",
    "question": "What is associated with Abnormal ductus choledochus morphology?",
    "seeds": [
      "Abnormal ductus choledochus morphology"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08887",
    "question": "What phenotype is associated with Thyroid hormonogenesis, genetic defect in, 2A?",
    "seeds": [
      "Thyroid hormonogenesis, genetic defect in, 2A"
    ],
    "gold_answer": "Goiter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08888",
    "question": "What is associated with Iliac artery aneurysm?",
    "seeds": [
      "Iliac artery aneurysm"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08889",
    "question": "What is associated with Nasolacrimal sac epithelial papillary carcinoma?",
    "seeds": [
      "Nasolacrimal sac epithelial papillary carcinoma"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08890",
    "question": "What is associated with Morphological central nervous system abnormality?",
    "seeds": [
      "Morphological central nervous system abnormality"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08891",
    "question": "What phenotype is associated with Hydroxylysinuria?",
    "seeds": [
      "Hydroxylysinuria"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08892",
    "question": "What is associated with Facial-lingual fasciculations?",
    "seeds": [
      "Facial-lingual fasciculations"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08893",
    "question": "What is associated with Congenital malformation of the left heart?",
    "seeds": [
      "Congenital malformation of the left heart"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08894",
    "question": "What is associated with Severe muscular hypotonia?",
    "seeds": [
      "Severe muscular hypotonia"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08895",
    "question": "What is associated with Charcot-Marie-Tooth disease and deafness?",
    "seeds": [
      "Charcot-Marie-Tooth disease and deafness"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08896",
    "question": "What is associated with Hyperhistidinemia?",
    "seeds": [
      "Hyperhistidinemia"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08897",
    "question": "What is associated with Sternocleidomastoid amyotrophy?",
    "seeds": [
      "Sternocleidomastoid amyotrophy"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08898",
    "question": "What is associated with Bidirectional ventricular ectopy?",
    "seeds": [
      "Bidirectional ventricular ectopy"
    ],
    "gold_answer": "Ventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08899",
    "question": "What is associated with Retinitis pigmentosa 59?",
    "seeds": [
      "Retinitis pigmentosa 59"
    ],
    "gold_answer": "Abnormal penis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08900",
    "question": "What is associated with Kappa Bence Jones proteinuria?",
    "seeds": [
      "Kappa Bence Jones proteinuria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08901",
    "question": "What is associated with Abnormal septum pellucidum morphology?",
    "seeds": [
      "Abnormal septum pellucidum morphology"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08902",
    "question": "What phenotype is associated with Gyrate atrophy of choroid and retina?",
    "seeds": [
      "Gyrate atrophy of choroid and retina"
    ],
    "gold_answer": "Chorioretinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08903",
    "question": "What is associated with Overhydrated hereditary stomatocytosis?",
    "seeds": [
      "Overhydrated hereditary stomatocytosis"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08904",
    "question": "What is associated with Synovial granuloma?",
    "seeds": [
      "Synovial granuloma"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08905",
    "question": "What is associated with Cerebellar cyst?",
    "seeds": [
      "Cerebellar cyst"
    ],
    "gold_answer": "Intracranial cystic lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08906",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 31?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 31"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08907",
    "question": "What is associated with Immediate Echolalia?",
    "seeds": [
      "Immediate Echolalia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08908",
    "question": "What phenotype is associated with Hypogonadotropic hypogonadism 5 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 5 with or without anosmia"
    ],
    "gold_answer": "Hypogonadotropic hypogonadism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08909",
    "question": "What is associated with Aplasia/Hypoplasia involving the femoral head and neck?",
    "seeds": [
      "Aplasia/Hypoplasia involving the femoral head and neck"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08910",
    "question": "What is associated with Hypomagnesemia 3, renal?",
    "seeds": [
      "Hypomagnesemia 3, renal"
    ],
    "gold_answer": "Abnormal drinking behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08911",
    "question": "What is associated with Spinocerebellar ataxia type 42?",
    "seeds": [
      "Spinocerebellar ataxia type 42"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08912",
    "question": "What is associated with Monorchism?",
    "seeds": [
      "Monorchism"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08913",
    "question": "What is associated with Postmenopausal onset?",
    "seeds": [
      "Postmenopausal onset"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08914",
    "question": "What is associated with Hypoplastic optic chiasm?",
    "seeds": [
      "Hypoplastic optic chiasm"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08915",
    "question": "What is associated with Retinal calcification?",
    "seeds": [
      "Retinal calcification"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08916",
    "question": "What is associated with Premature fusion of phalangeal epiphyses?",
    "seeds": [
      "Premature fusion of phalangeal epiphyses"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08917",
    "question": "What is associated with Abnormality of premolar?",
    "seeds": [
      "Abnormality of premolar"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08918",
    "question": "What is associated with Potocki-Lupski syndrome?",
    "seeds": [
      "Potocki-Lupski syndrome"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08919",
    "question": "What is associated with Abnormality of the epiphyses of the feet?",
    "seeds": [
      "Abnormality of the epiphyses of the feet"
    ],
    "gold_answer": "Abnormal lower limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08920",
    "question": "What is associated with Balanced double aortic arch?",
    "seeds": [
      "Balanced double aortic arch"
    ],
    "gold_answer": "Abnormal branching pattern of the aortic arch",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08921",
    "question": "What phenotype is associated with Earring holes, natural?",
    "seeds": [
      "Earring holes, natural"
    ],
    "gold_answer": "Congenital earlobe sinuses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08922",
    "question": "What is associated with Anterior pituitary dysgenesis?",
    "seeds": [
      "Anterior pituitary dysgenesis"
    ],
    "gold_answer": "Abnormality of the anterior pituitary",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08923",
    "question": "What is associated with Osteoporotic humerus?",
    "seeds": [
      "Osteoporotic humerus"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08924",
    "question": "What is associated with Microcystic stromal tumor?",
    "seeds": [
      "Microcystic stromal tumor"
    ],
    "gold_answer": "CTNNB1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "candidate_gene_tested_in"
    }
  },
  {
    "query_id": "orph_train_08925",
    "question": "What is associated with Common atrium?",
    "seeds": [
      "Common atrium"
    ],
    "gold_answer": "Abnormal cardiac atrium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08926",
    "question": "What is associated with Bullous pemphigoid?",
    "seeds": [
      "Bullous pemphigoid"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08927",
    "question": "What is associated with Paroxysmal extreme pain disorder?",
    "seeds": [
      "Paroxysmal extreme pain disorder"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08928",
    "question": "What is associated with Herpetiform?",
    "seeds": [
      "Herpetiform"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08929",
    "question": "What is associated with Dystonia, early-onset, and/or spastic paraplegia?",
    "seeds": [
      "Dystonia, early-onset, and/or spastic paraplegia"
    ],
    "gold_answer": "Dysphonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08930",
    "question": "What is associated with Deformed tarsal bones?",
    "seeds": [
      "Deformed tarsal bones"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08931",
    "question": "What is associated with Tarsal synostosis?",
    "seeds": [
      "Tarsal synostosis"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08932",
    "question": "What phenotype is associated with Arthrogryposis multiplex congenita 3, myogenic type?",
    "seeds": [
      "Arthrogryposis multiplex congenita 3, myogenic type"
    ],
    "gold_answer": "Hypermetropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08933",
    "question": "What is associated with Abnormality of the cervical spine?",
    "seeds": [
      "Abnormality of the cervical spine"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08934",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 44?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 44"
    ],
    "gold_answer": "CNS hypomyelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08935",
    "question": "What is associated with Pain at the anterior aspect of the elbow?",
    "seeds": [
      "Pain at the anterior aspect of the elbow"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08936",
    "question": "What is associated with Absent epiphyses of the 4th toe?",
    "seeds": [
      "Absent epiphyses of the 4th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08937",
    "question": "What is associated with Mitochondrial complex IV deficiency, nuclear type 23?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 23"
    ],
    "gold_answer": "Hernia of the abdominal wall",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08938",
    "question": "What is associated with EEG with focal sharp slow waves?",
    "seeds": [
      "EEG with focal sharp slow waves"
    ],
    "gold_answer": "Interictal EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08939",
    "question": "What is associated with Abnormal tongue physiology?",
    "seeds": [
      "Abnormal tongue physiology"
    ],
    "gold_answer": "Abnormal oral physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08940",
    "question": "What phenotype is associated with Combined immunodeficiency-multiple intestinal atresia?",
    "seeds": [
      "Combined immunodeficiency-multiple intestinal atresia"
    ],
    "gold_answer": "Intestinal malrotation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08941",
    "question": "What is associated with Abnormal glomerular mesangial cellularity?",
    "seeds": [
      "Abnormal glomerular mesangial cellularity"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08942",
    "question": "What is associated with Reduced tissue fructose-1,6-bisphosphatase activity?",
    "seeds": [
      "Reduced tissue fructose-1,6-bisphosphatase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08943",
    "question": "What is associated with Weak voice?",
    "seeds": [
      "Weak voice"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08944",
    "question": "What is associated with Reduced erythrocyte galactokinase activity?",
    "seeds": [
      "Reduced erythrocyte galactokinase activity"
    ],
    "gold_answer": "Abnormal erythrocyte enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08945",
    "question": "What is associated with Blindness?",
    "seeds": [
      "Blindness"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08946",
    "question": "What is associated with Subsolid pulmonary nodule?",
    "seeds": [
      "Subsolid pulmonary nodule"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08947",
    "question": "What phenotype is associated with Hand-foot-uterus syndrome?",
    "seeds": [
      "Hand-foot-uterus syndrome"
    ],
    "gold_answer": "Micropenis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08948",
    "question": "What is associated with Organized thrombi within interlobular vein lumen?",
    "seeds": [
      "Organized thrombi within interlobular vein lumen"
    ],
    "gold_answer": "Abnormal interlobular vein lumen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08949",
    "question": "What is associated with Monocular horizontal nystagmus?",
    "seeds": [
      "Monocular horizontal nystagmus"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08950",
    "question": "What is associated with Abnormal pulmonary artery physiology?",
    "seeds": [
      "Abnormal pulmonary artery physiology"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08951",
    "question": "What is associated with Tetraphocomelia?",
    "seeds": [
      "Tetraphocomelia"
    ],
    "gold_answer": "Phocomelia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08952",
    "question": "What is associated with Paraseptal?",
    "seeds": [
      "Paraseptal"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08953",
    "question": "What phenotype is associated with Hypertrophic neuropathy of dejerine-sottas?",
    "seeds": [
      "Hypertrophic neuropathy of dejerine-sottas"
    ],
    "gold_answer": "Hyporeflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08954",
    "question": "What is associated with Glomerular proteinuria?",
    "seeds": [
      "Glomerular proteinuria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08955",
    "question": "What phenotype is associated with Aniridia-renal agenesis-psychomotor retardation syndrome?",
    "seeds": [
      "Aniridia-renal agenesis-psychomotor retardation syndrome"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08956",
    "question": "What is associated with Cardiorespiratory arrest?",
    "seeds": [
      "Cardiorespiratory arrest"
    ],
    "gold_answer": "Respiratory arrest",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08957",
    "question": "What is associated with Periorbital hyperpigmentation?",
    "seeds": [
      "Periorbital hyperpigmentation"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08958",
    "question": "What is associated with Bilateral basilar pulmonary fibrosis?",
    "seeds": [
      "Bilateral basilar pulmonary fibrosis"
    ],
    "gold_answer": "Pulmonary fibrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08959",
    "question": "What is associated with Mitochondrial DNA depletion syndrome, hepatocerebrorenal form?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome, hepatocerebrorenal form"
    ],
    "gold_answer": "TWNK",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_08960",
    "question": "What is associated with EEG with parietal epileptiform discharges?",
    "seeds": [
      "EEG with parietal epileptiform discharges"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08961",
    "question": "What phenotype is associated with Solitary median maxillary central incisor?",
    "seeds": [
      "Solitary median maxillary central incisor"
    ],
    "gold_answer": "Choanal atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08962",
    "question": "What is associated with Richards-Rundle syndrome?",
    "seeds": [
      "Richards-Rundle syndrome"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08963",
    "question": "What is associated with Xq21 microdeletion syndrome?",
    "seeds": [
      "Xq21 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08964",
    "question": "What is associated with Thrombophiliavenous thromboembolism, included?",
    "seeds": [
      "Thrombophiliavenous thromboembolism, included"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08965",
    "question": "What is associated with Aplasia/Hypoplasia of the tragus?",
    "seeds": [
      "Aplasia/Hypoplasia of the tragus"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08966",
    "question": "What is associated with Melasma?",
    "seeds": [
      "Melasma"
    ],
    "gold_answer": "Hyperpigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08967",
    "question": "What is associated with Positive meconium methadone test?",
    "seeds": [
      "Positive meconium methadone test"
    ],
    "gold_answer": "Stool xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08968",
    "question": "What is associated with Renal medullary interstitial inflammation?",
    "seeds": [
      "Renal medullary interstitial inflammation"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08969",
    "question": "What is associated with Aortopulmonary collateral arteries?",
    "seeds": [
      "Aortopulmonary collateral arteries"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08970",
    "question": "What is associated with Blood group antigen abnormality?",
    "seeds": [
      "Blood group antigen abnormality"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08971",
    "question": "What is associated with Complete duplication of the middle phalanx of the 5th toe?",
    "seeds": [
      "Complete duplication of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Duplication of the middle phalanx of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08972",
    "question": "What is associated with Brain malformation-congenital heart disease-postaxial polydactyly syndrome?",
    "seeds": [
      "Brain malformation-congenital heart disease-postaxial polydactyly syndrome"
    ],
    "gold_answer": "Hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08973",
    "question": "What phenotype is associated with Idiopathic steroid-resistant nephrotic syndrome?",
    "seeds": [
      "Idiopathic steroid-resistant nephrotic syndrome"
    ],
    "gold_answer": "Minimal change glomerulonephritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08974",
    "question": "What is associated with Ureteral obstruction?",
    "seeds": [
      "Ureteral obstruction"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08975",
    "question": "What phenotype is associated with Bone mineral density QTL 15?",
    "seeds": [
      "Bone mineral density QTL 15"
    ],
    "gold_answer": "Recurrent fractures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08976",
    "question": "What is associated with Increased fecal isocoproporphyrin?",
    "seeds": [
      "Increased fecal isocoproporphyrin"
    ],
    "gold_answer": "Increased fecal porphyrin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08977",
    "question": "What is associated with Fibromuscular dysplasia, multifocal?",
    "seeds": [
      "Fibromuscular dysplasia, multifocal"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08978",
    "question": "What phenotype is associated with Congenital myopathy 10B, mild variant?",
    "seeds": [
      "Congenital myopathy 10B, mild variant"
    ],
    "gold_answer": "Difficulty climbing stairs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08979",
    "question": "What is associated with Abnormality of the distal phalanx of the 5th toe?",
    "seeds": [
      "Abnormality of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08980",
    "question": "What is associated with Atrophodermia vermiculata?",
    "seeds": [
      "Atrophodermia vermiculata"
    ],
    "gold_answer": "Scarring",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08981",
    "question": "What is associated with Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies?",
    "seeds": [
      "Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies"
    ],
    "gold_answer": "Abnormality of the curvature of the cornea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08982",
    "question": "What is associated with Abnormality of inferior alveolar nerve?",
    "seeds": [
      "Abnormality of inferior alveolar nerve"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08983",
    "question": "What phenotype is associated with Hyperparathyroidism, transient neonatal?",
    "seeds": [
      "Hyperparathyroidism, transient neonatal"
    ],
    "gold_answer": "Subperiosteal bone formation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08984",
    "question": "What is associated with PRUNE1-related neurological syndrome?",
    "seeds": [
      "PRUNE1-related neurological syndrome"
    ],
    "gold_answer": "Cortical dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08985",
    "question": "What is associated with Glomerular fibronectin deposits?",
    "seeds": [
      "Glomerular fibronectin deposits"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08986",
    "question": "What is associated with Glycopeptiduria?",
    "seeds": [
      "Glycopeptiduria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08987",
    "question": "What is associated with Subcutaneous emphysema?",
    "seeds": [
      "Subcutaneous emphysema"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08988",
    "question": "What is associated with Sorsby fundus dystrophy?",
    "seeds": [
      "Sorsby fundus dystrophy"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08989",
    "question": "What phenotype is associated with Ichthyosis-intellectual disability-dwarfism-renal impairment syndrome?",
    "seeds": [
      "Ichthyosis-intellectual disability-dwarfism-renal impairment syndrome"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08990",
    "question": "What is associated with Frequent Giardia lamblia infestation?",
    "seeds": [
      "Frequent Giardia lamblia infestation"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08991",
    "question": "What is associated with Generalized clonic seizure?",
    "seeds": [
      "Generalized clonic seizure"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08992",
    "question": "What is associated with Idiopathic anaphylaxis?",
    "seeds": [
      "Idiopathic anaphylaxis"
    ],
    "gold_answer": "Anaphylactic shock",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08993",
    "question": "What is associated with Deviation of the hand or of fingers of the hand?",
    "seeds": [
      "Deviation of the hand or of fingers of the hand"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08994",
    "question": "What is associated with Amelogenesis imperfecta, type IIA5?",
    "seeds": [
      "Amelogenesis imperfecta, type IIA5"
    ],
    "gold_answer": "Abnormal dental morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08995",
    "question": "What is associated with Polyclonal elevated circulating IgE concentration?",
    "seeds": [
      "Polyclonal elevated circulating IgE concentration"
    ],
    "gold_answer": "Increased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08996",
    "question": "What is associated with Renal fibrosis?",
    "seeds": [
      "Renal fibrosis"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08997",
    "question": "What phenotype is associated with Alcohol sensitivity, acute?",
    "seeds": [
      "Alcohol sensitivity, acute"
    ],
    "gold_answer": "Reduced acetaldehyde dehydrogenase level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_08998",
    "question": "What is associated with Anal canal squamous cell carcinoma?",
    "seeds": [
      "Anal canal squamous cell carcinoma"
    ],
    "gold_answer": "Neoplasm of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_08999",
    "question": "What is associated with Placental abruption?",
    "seeds": [
      "Placental abruption"
    ],
    "gold_answer": "Abnormal placenta morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09000",
    "question": "What is associated with Intellectual developmental disorder, X-linked 90?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 90"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09001",
    "question": "What phenotype is associated with Rett syndrome?",
    "seeds": [
      "Rett syndrome"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09002",
    "question": "What is associated with Irregular epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Irregular epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09003",
    "question": "What is associated with Webbed penis?",
    "seeds": [
      "Webbed penis"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09004",
    "question": "What is associated with IgA NEPHROPATHY, SUSCEPTIBILITY TO, 2?",
    "seeds": [
      "IgA NEPHROPATHY, SUSCEPTIBILITY TO, 2"
    ],
    "gold_answer": "Abnormal urine cytology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09005",
    "question": "What is associated with Exudative vitreoretinopathy 3?",
    "seeds": [
      "Exudative vitreoretinopathy 3"
    ],
    "gold_answer": "Retinal perforation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09006",
    "question": "What is associated with Chromosome 3q29 duplication syndrome?",
    "seeds": [
      "Chromosome 3q29 duplication syndrome"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09007",
    "question": "What phenotype is associated with Microphthalmia, isolated, with coloboma 9?",
    "seeds": [
      "Microphthalmia, isolated, with coloboma 9"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09008",
    "question": "What is associated with Absent nasal septal cartilage?",
    "seeds": [
      "Absent nasal septal cartilage"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09009",
    "question": "What phenotype is associated with Leukemia, acute lymphocytic, susceptibility to, 1?",
    "seeds": [
      "Leukemia, acute lymphocytic, susceptibility to, 1"
    ],
    "gold_answer": "Acute lymphoblastic leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09010",
    "question": "What is associated with Positive anterior drawer test?",
    "seeds": [
      "Positive anterior drawer test"
    ],
    "gold_answer": "Abnormality of the ankle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09011",
    "question": "What is associated with Odonto-onycho dysplasia-alopecia syndrome?",
    "seeds": [
      "Odonto-onycho dysplasia-alopecia syndrome"
    ],
    "gold_answer": "Abnormal toenail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09012",
    "question": "What is associated with Coronary cameral fistula to right ventricle?",
    "seeds": [
      "Coronary cameral fistula to right ventricle"
    ],
    "gold_answer": "Coronary artery fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09013",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 76?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 76"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09014",
    "question": "What is associated with Ambiguous genitalia, male?",
    "seeds": [
      "Ambiguous genitalia, male"
    ],
    "gold_answer": "Abnormal external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09015",
    "question": "What is associated with Jaw contracture?",
    "seeds": [
      "Jaw contracture"
    ],
    "gold_answer": "Joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09016",
    "question": "What is associated with Neurodevelopmental disorder with spasticity, seizures, and brain abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with spasticity, seizures, and brain abnormalities"
    ],
    "gold_answer": "Abnormal cerebral cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09017",
    "question": "What is associated with Hydrolethalus syndrome 1?",
    "seeds": [
      "Hydrolethalus syndrome 1"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09018",
    "question": "What is associated with Spinocerebellar ataxia 13?",
    "seeds": [
      "Spinocerebellar ataxia 13"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09019",
    "question": "What is associated with Hypodysplasia of the corpus callosum?",
    "seeds": [
      "Hypodysplasia of the corpus callosum"
    ],
    "gold_answer": "Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09020",
    "question": "What is associated with Nematode in retina?",
    "seeds": [
      "Nematode in retina"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09021",
    "question": "What phenotype is associated with Antithrombin III deficiency?",
    "seeds": [
      "Antithrombin III deficiency"
    ],
    "gold_answer": "Recurrent thrombophlebitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09022",
    "question": "What phenotype is associated with Heterotaxy, visceral, 1, X-linked?",
    "seeds": [
      "Heterotaxy, visceral, 1, X-linked"
    ],
    "gold_answer": "Abnormality of pulmonary situs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09023",
    "question": "What is associated with Decreased renal tubular phosphate excretion?",
    "seeds": [
      "Decreased renal tubular phosphate excretion"
    ],
    "gold_answer": "Abnormality of renal excretion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09024",
    "question": "What phenotype is associated with Immunodeficiency 93 and hypertrophic cardiomyopathy?",
    "seeds": [
      "Immunodeficiency 93 and hypertrophic cardiomyopathy"
    ],
    "gold_answer": "Palpitations",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09025",
    "question": "What is associated with Limb joint contracture?",
    "seeds": [
      "Limb joint contracture"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09026",
    "question": "What is associated with Marshall-Smith syndrome?",
    "seeds": [
      "Marshall-Smith syndrome"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09027",
    "question": "What phenotype is associated with Chronic granulomatous disease 2, autosomal recessive?",
    "seeds": [
      "Chronic granulomatous disease 2, autosomal recessive"
    ],
    "gold_answer": "Axillary lymphadenopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09028",
    "question": "What is associated with Physical urticaria?",
    "seeds": [
      "Physical urticaria"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09029",
    "question": "What is associated with Rest dyspnea?",
    "seeds": [
      "Rest dyspnea"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09030",
    "question": "What is associated with Abnormality of the testis size?",
    "seeds": [
      "Abnormality of the testis size"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09031",
    "question": "What is associated with Increased circulating IgD concentration?",
    "seeds": [
      "Increased circulating IgD concentration"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09032",
    "question": "What is associated with Abnormal pulmonary valve physiology?",
    "seeds": [
      "Abnormal pulmonary valve physiology"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09033",
    "question": "What is associated with Arthrogryposis, distal, type 1A?",
    "seeds": [
      "Arthrogryposis, distal, type 1A"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09034",
    "question": "What is associated with Abnormal ulnar styloid process morphology?",
    "seeds": [
      "Abnormal ulnar styloid process morphology"
    ],
    "gold_answer": "Abnormal ulnar epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09035",
    "question": "What is associated with Mandibular condyle hypoplasia?",
    "seeds": [
      "Mandibular condyle hypoplasia"
    ],
    "gold_answer": "Micrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09036",
    "question": "What is associated with Absent lanugo?",
    "seeds": [
      "Absent lanugo"
    ],
    "gold_answer": "Abnormal fetal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09037",
    "question": "What is associated with Microspherophakia?",
    "seeds": [
      "Microspherophakia"
    ],
    "gold_answer": "Aplasia/Hypoplasia affecting the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09038",
    "question": "What is associated with Epilepsy, early-onset, 3, with or without developmental delay?",
    "seeds": [
      "Epilepsy, early-onset, 3, with or without developmental delay"
    ],
    "gold_answer": "Infection-related seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09039",
    "question": "What is associated with Distal symphalangism?",
    "seeds": [
      "Distal symphalangism"
    ],
    "gold_answer": "Synostosis of joints",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09040",
    "question": "What is associated with Social anxiety?",
    "seeds": [
      "Social anxiety"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09041",
    "question": "What is associated with Renal arteriole medial atrophy?",
    "seeds": [
      "Renal arteriole medial atrophy"
    ],
    "gold_answer": "Abnormal renal arteriole intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09042",
    "question": "What is associated with Abnormal circulating dicarboxylic acid concentration?",
    "seeds": [
      "Abnormal circulating dicarboxylic acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09043",
    "question": "What is associated with Hyperparathyroidism 1?",
    "seeds": [
      "Hyperparathyroidism 1"
    ],
    "gold_answer": "Abnormality of the parathyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09044",
    "question": "What is associated with Urinary bladder sphincter dysfunction?",
    "seeds": [
      "Urinary bladder sphincter dysfunction"
    ],
    "gold_answer": "Abnormality of the lower urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09045",
    "question": "What is associated with Partial absence of specific antibody response to unconjugated pneumococcus vaccine?",
    "seeds": [
      "Partial absence of specific antibody response to unconjugated pneumococcus vaccine"
    ],
    "gold_answer": "Decreased circulating level of specific antibody",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09046",
    "question": "What is associated with Scheuermann-like vertebral changes?",
    "seeds": [
      "Scheuermann-like vertebral changes"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09047",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 62?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 62"
    ],
    "gold_answer": "Lower limb spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09048",
    "question": "What is associated with Florid cemento-osseous dysplasia?",
    "seeds": [
      "Florid cemento-osseous dysplasia"
    ],
    "gold_answer": "Bone cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09049",
    "question": "What is associated with Cementum hypoplasia?",
    "seeds": [
      "Cementum hypoplasia"
    ],
    "gold_answer": "Abnormal cementum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09050",
    "question": "What is associated with Facial hemangioma?",
    "seeds": [
      "Facial hemangioma"
    ],
    "gold_answer": "Vascular neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09051",
    "question": "What is associated with Short iliac bones?",
    "seeds": [
      "Short iliac bones"
    ],
    "gold_answer": "Abnormal hip bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09052",
    "question": "What is associated with Reduced contraction of the left ventricular apex?",
    "seeds": [
      "Reduced contraction of the left ventricular apex"
    ],
    "gold_answer": "Abnormal cardiac ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09053",
    "question": "What is associated with Immunodeficiency 133 with autoimmunity and autoinflammation?",
    "seeds": [
      "Immunodeficiency 133 with autoimmunity and autoinflammation"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09054",
    "question": "What is associated with Fragile teeth?",
    "seeds": [
      "Fragile teeth"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09055",
    "question": "What is associated with Vici syndrome?",
    "seeds": [
      "Vici syndrome"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09056",
    "question": "What is associated with Oral-pharyngeal dysphagia?",
    "seeds": [
      "Oral-pharyngeal dysphagia"
    ],
    "gold_answer": "Dysphagia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09057",
    "question": "What is associated with Abnormality of vitamin metabolism?",
    "seeds": [
      "Abnormality of vitamin metabolism"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09058",
    "question": "What is associated with Elevated circulating linoleylcarnitine concentration?",
    "seeds": [
      "Elevated circulating linoleylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09059",
    "question": "What is associated with Anti-tissue transglutaminase antibody positivity?",
    "seeds": [
      "Anti-tissue transglutaminase antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09060",
    "question": "What is associated with Retinal capillary hemangioma?",
    "seeds": [
      "Retinal capillary hemangioma"
    ],
    "gold_answer": "Hemangioblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09061",
    "question": "What is associated with Fractured manual digit bone?",
    "seeds": [
      "Fractured manual digit bone"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09062",
    "question": "What is associated with Paraparesis?",
    "seeds": [
      "Paraparesis"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09063",
    "question": "What phenotype is associated with PLEC-related intermediate epidermolysis bullosa simplex without extracutaneous involvement?",
    "seeds": [
      "PLEC-related intermediate epidermolysis bullosa simplex without extracutaneous involvement"
    ],
    "gold_answer": "Palmoplantar blistering",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09064",
    "question": "What phenotype is associated with Arachnoid cyst?",
    "seeds": [
      "Arachnoid cyst"
    ],
    "gold_answer": "Respiratory insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09065",
    "question": "What is associated with Enlarged joints?",
    "seeds": [
      "Enlarged joints"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09066",
    "question": "What is associated with Splayed fingers?",
    "seeds": [
      "Splayed fingers"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09067",
    "question": "What is associated with Cold-induced muscle cramps?",
    "seeds": [
      "Cold-induced muscle cramps"
    ],
    "gold_answer": "Muscle spasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09068",
    "question": "What is associated with Bacteria allergy?",
    "seeds": [
      "Bacteria allergy"
    ],
    "gold_answer": "Allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09069",
    "question": "What phenotype is associated with Immunodeficiency 48?",
    "seeds": [
      "Immunodeficiency 48"
    ],
    "gold_answer": "Chronic diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09070",
    "question": "What is associated with Distal deletion 10p syndrome?",
    "seeds": [
      "Distal deletion 10p syndrome"
    ],
    "gold_answer": "Abnormality of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09071",
    "question": "What is associated with Lip hyperpigmentation?",
    "seeds": [
      "Lip hyperpigmentation"
    ],
    "gold_answer": "Abnormal lip pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09072",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 57?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 57"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09073",
    "question": "What phenotype is associated with Pentalogy of Cantrell?",
    "seeds": [
      "Pentalogy of Cantrell"
    ],
    "gold_answer": "Vesicoureteral reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09074",
    "question": "What is associated with Recombinant 8 syndrome?",
    "seeds": [
      "Recombinant 8 syndrome"
    ],
    "gold_answer": "Abnormality of the gingiva",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09075",
    "question": "What is associated with Medial humerus epicondyle avulsion fracture?",
    "seeds": [
      "Medial humerus epicondyle avulsion fracture"
    ],
    "gold_answer": "Abnormal medial epicondyle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09076",
    "question": "What is associated with Nephropathy?",
    "seeds": [
      "Nephropathy"
    ],
    "gold_answer": "Abnormality of the urinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09077",
    "question": "What is associated with Abnormal erythroid lineage cell morphology?",
    "seeds": [
      "Abnormal erythroid lineage cell morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09078",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09079",
    "question": "What phenotype is associated with Arterial dissection-lentiginosis syndrome?",
    "seeds": [
      "Arterial dissection-lentiginosis syndrome"
    ],
    "gold_answer": "Hemiparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09080",
    "question": "What phenotype is associated with Autism spectrum disorder due to AUTS2 deficiency?",
    "seeds": [
      "Autism spectrum disorder due to AUTS2 deficiency"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09081",
    "question": "What is associated with Toxemia of pregnancy?",
    "seeds": [
      "Toxemia of pregnancy"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09082",
    "question": "What is associated with Thyrotoxic periodic paralysis, susceptibility to, 1?",
    "seeds": [
      "Thyrotoxic periodic paralysis, susceptibility to, 1"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09083",
    "question": "What is associated with Hiker's feet?",
    "seeds": [
      "Hiker's feet"
    ],
    "gold_answer": "Abnormality of the plantar skin of foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09084",
    "question": "What is associated with X-linked intellectual disability-limb spasticity-retinal dystrophy-arginine vasopressin deficiency?",
    "seeds": [
      "X-linked intellectual disability-limb spasticity-retinal dystrophy-arginine vasopressin deficiency"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09085",
    "question": "What is associated with Huriez syndrome?",
    "seeds": [
      "Huriez syndrome"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09086",
    "question": "What phenotype is associated with Hypogonadotropic hypogonadism 14 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 14 with or without anosmia"
    ],
    "gold_answer": "Primary amenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09087",
    "question": "What is associated with Pathological inclusion body by anatomical location?",
    "seeds": [
      "Pathological inclusion body by anatomical location"
    ],
    "gold_answer": "Pathological inclusion body",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09088",
    "question": "What is associated with Diaphyseal medullary stenosis-bone malignancy syndrome?",
    "seeds": [
      "Diaphyseal medullary stenosis-bone malignancy syndrome"
    ],
    "gold_answer": "MTAP",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09089",
    "question": "What is associated with Foveal retinal pigment epithelial loss on macular OCT?",
    "seeds": [
      "Foveal retinal pigment epithelial loss on macular OCT"
    ],
    "gold_answer": "Abnormal retinal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09090",
    "question": "What is associated with Progressive bifocal chorioretinal atrophy?",
    "seeds": [
      "Progressive bifocal chorioretinal atrophy"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09091",
    "question": "What is associated with Abnormality of the xiphoid process?",
    "seeds": [
      "Abnormality of the xiphoid process"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09092",
    "question": "What phenotype is associated with CHIME syndrome?",
    "seeds": [
      "CHIME syndrome"
    ],
    "gold_answer": "Thin corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09093",
    "question": "What is associated with Labial adhesion?",
    "seeds": [
      "Labial adhesion"
    ],
    "gold_answer": "Abnormal labia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09094",
    "question": "What phenotype is associated with Spastic paraplegia 36, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 36, autosomal dominant"
    ],
    "gold_answer": "Pes cavus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09095",
    "question": "What is associated with Panhypopituitarism, X-linked?",
    "seeds": [
      "Panhypopituitarism, X-linked"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09096",
    "question": "What is associated with Chronic hepatitis due to cryptosporidium infection?",
    "seeds": [
      "Chronic hepatitis due to cryptosporidium infection"
    ],
    "gold_answer": "Hepatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09097",
    "question": "What is associated with Automatic atrial tachycardia?",
    "seeds": [
      "Automatic atrial tachycardia"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09098",
    "question": "What is associated with Abnormality of the first metatarsal bone?",
    "seeds": [
      "Abnormality of the first metatarsal bone"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09099",
    "question": "What is associated with Intestinal perforation?",
    "seeds": [
      "Intestinal perforation"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09100",
    "question": "What is associated with Anti-annexin-V antibody positivity?",
    "seeds": [
      "Anti-annexin-V antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09101",
    "question": "What is associated with Spinal cord tumor?",
    "seeds": [
      "Spinal cord tumor"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09102",
    "question": "What is associated with Fractured thoracic vertebra?",
    "seeds": [
      "Fractured thoracic vertebra"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09103",
    "question": "What is associated with Methylmalonyl-Coa epimerase deficiency?",
    "seeds": [
      "Methylmalonyl-Coa epimerase deficiency"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09104",
    "question": "What is associated with Hypothyroidism, congenital, nongoitrous, 7?",
    "seeds": [
      "Hypothyroidism, congenital, nongoitrous, 7"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09105",
    "question": "What is associated with Mucolipidosis IV?",
    "seeds": [
      "Mucolipidosis IV"
    ],
    "gold_answer": "Sensory behavioral abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09106",
    "question": "What is associated with Myxomatous mitral valve degeneration?",
    "seeds": [
      "Myxomatous mitral valve degeneration"
    ],
    "gold_answer": "Abnormal atrioventricular valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09107",
    "question": "What is associated with Symptomatic seizures?",
    "seeds": [
      "Symptomatic seizures"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09108",
    "question": "What is associated with Fractured patella?",
    "seeds": [
      "Fractured patella"
    ],
    "gold_answer": "Abnormality of the knee",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09109",
    "question": "What phenotype is associated with Wilms tumor 5?",
    "seeds": [
      "Wilms tumor 5"
    ],
    "gold_answer": "Nephroblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09110",
    "question": "What is associated with Decreased specific anti-polysaccharide antibody level?",
    "seeds": [
      "Decreased specific anti-polysaccharide antibody level"
    ],
    "gold_answer": "Decreased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09111",
    "question": "What is associated with Elevated leukocyte alkaline phosphatase?",
    "seeds": [
      "Elevated leukocyte alkaline phosphatase"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09112",
    "question": "What phenotype is associated with Mosaic trisomy 15 syndrome?",
    "seeds": [
      "Mosaic trisomy 15 syndrome"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09113",
    "question": "What is associated with Glomerular subendothelial electron-dense deposits?",
    "seeds": [
      "Glomerular subendothelial electron-dense deposits"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09114",
    "question": "What is associated with Pustulosis palmaris et plantaris?",
    "seeds": [
      "Pustulosis palmaris et plantaris"
    ],
    "gold_answer": "IL36RN",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09115",
    "question": "What is associated with Limb duplication?",
    "seeds": [
      "Limb duplication"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09116",
    "question": "What is associated with Dysostosis multiplex?",
    "seeds": [
      "Dysostosis multiplex"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09117",
    "question": "What is associated with Hypothyroidism due to deficient transcription factors involved in pituitary development or function?",
    "seeds": [
      "Hypothyroidism due to deficient transcription factors involved in pituitary development or function"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09118",
    "question": "What is associated with High anterior hairline?",
    "seeds": [
      "High anterior hairline"
    ],
    "gold_answer": "Abnormality of the hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09119",
    "question": "What phenotype is associated with Hydrocephalus, endocardial fibroelastosis, and cataracts?",
    "seeds": [
      "Hydrocephalus, endocardial fibroelastosis, and cataracts"
    ],
    "gold_answer": "Endocardial fibroelastosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09120",
    "question": "What is associated with Slender middle phalanx of finger?",
    "seeds": [
      "Slender middle phalanx of finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09121",
    "question": "What is associated with Increased endomysial connective tissue?",
    "seeds": [
      "Increased endomysial connective tissue"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09122",
    "question": "What is associated with Hypoplastic ventricle?",
    "seeds": [
      "Hypoplastic ventricle"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09123",
    "question": "What is associated with Increased serum sorbitol concentration?",
    "seeds": [
      "Increased serum sorbitol concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09124",
    "question": "What is associated with Japanese encephalitis?",
    "seeds": [
      "Japanese encephalitis"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09125",
    "question": "What is associated with Reduced branched-chain alpha-keto acid dehydrogenase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced branched-chain alpha-keto acid dehydrogenase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09126",
    "question": "What is associated with Short intermamillary distance?",
    "seeds": [
      "Short intermamillary distance"
    ],
    "gold_answer": "Abnormal nipple morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09127",
    "question": "What is associated with Corneal crystals?",
    "seeds": [
      "Corneal crystals"
    ],
    "gold_answer": "Opacification of the corneal stroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09128",
    "question": "What is associated with Abnormality of hair growth?",
    "seeds": [
      "Abnormality of hair growth"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09129",
    "question": "What is associated with Metachromatic leukodystrophy, adult form?",
    "seeds": [
      "Metachromatic leukodystrophy, adult form"
    ],
    "gold_answer": "ARSA",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_09130",
    "question": "What is associated with Growth hormone deficiency, isolated, type IB?",
    "seeds": [
      "Growth hormone deficiency, isolated, type IB"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09131",
    "question": "What is associated with Abnormal distal ulnar epiphysis morphology?",
    "seeds": [
      "Abnormal distal ulnar epiphysis morphology"
    ],
    "gold_answer": "Abnormal ulnar epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09132",
    "question": "What phenotype is associated with Autosomal dominant severe congenital neutropenia?",
    "seeds": [
      "Autosomal dominant severe congenital neutropenia"
    ],
    "gold_answer": "Leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09133",
    "question": "What is associated with Fetal distress?",
    "seeds": [
      "Fetal distress"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09134",
    "question": "What is associated with Metaphyseal undermodelling?",
    "seeds": [
      "Metaphyseal undermodelling"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09135",
    "question": "What is associated with Pleural plaque?",
    "seeds": [
      "Pleural plaque"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09136",
    "question": "What is associated with Pinhole visual acuity 1.2 LogMAR?",
    "seeds": [
      "Pinhole visual acuity 1.2 LogMAR"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09137",
    "question": "What is associated with Infantile LAD-like disease due to RAC2 deficiency?",
    "seeds": [
      "Infantile LAD-like disease due to RAC2 deficiency"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09138",
    "question": "What phenotype is associated with Lethal hemolytic anemia-genital anomalies syndrome?",
    "seeds": [
      "Lethal hemolytic anemia-genital anomalies syndrome"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09139",
    "question": "What is associated with Flared metaphysis?",
    "seeds": [
      "Flared metaphysis"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09140",
    "question": "What is associated with Abnormal pectoral muscle morphology?",
    "seeds": [
      "Abnormal pectoral muscle morphology"
    ],
    "gold_answer": "Abnormality of the musculature of the thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09141",
    "question": "What is associated with Spinocerebellar ataxia 19?",
    "seeds": [
      "Spinocerebellar ataxia 19"
    ],
    "gold_answer": "Gaze-evoked nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09142",
    "question": "What is associated with Otospondylomegaepiphyseal dysplasia?",
    "seeds": [
      "Otospondylomegaepiphyseal dysplasia"
    ],
    "gold_answer": "Abnormality of the mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09143",
    "question": "What is associated with Androgen insufficiency?",
    "seeds": [
      "Androgen insufficiency"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09144",
    "question": "What is associated with Bifid clitoris?",
    "seeds": [
      "Bifid clitoris"
    ],
    "gold_answer": "Abnormal female external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09145",
    "question": "What is associated with Aplasia/hypoplasia of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Aplasia/hypoplasia of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09146",
    "question": "What is associated with Broad ischia?",
    "seeds": [
      "Broad ischia"
    ],
    "gold_answer": "Abnormal hip bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09147",
    "question": "What is associated with Undetectable light- and dark-adapted electroretinogram?",
    "seeds": [
      "Undetectable light- and dark-adapted electroretinogram"
    ],
    "gold_answer": "Abnormal electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09148",
    "question": "What is associated with Small finger?",
    "seeds": [
      "Small finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09149",
    "question": "What is associated with Posterior mediastinal mass?",
    "seeds": [
      "Posterior mediastinal mass"
    ],
    "gold_answer": "Inferior mediastinal mass",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09150",
    "question": "What is associated with Elevated circulating medium-chain acylcarnitine concentration?",
    "seeds": [
      "Elevated circulating medium-chain acylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09151",
    "question": "What is associated with Glomerular endocapillary leukocyte hypercellularity?",
    "seeds": [
      "Glomerular endocapillary leukocyte hypercellularity"
    ],
    "gold_answer": "Abnormal glomerular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09152",
    "question": "What is associated with Abnormal wrist physiology?",
    "seeds": [
      "Abnormal wrist physiology"
    ],
    "gold_answer": "Abnormality of the wrist",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09153",
    "question": "What is associated with Decreased plasma free carnitine?",
    "seeds": [
      "Decreased plasma free carnitine"
    ],
    "gold_answer": "Decreased circulating carnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09154",
    "question": "What is associated with Healthy?",
    "seeds": [
      "Healthy"
    ],
    "gold_answer": "Health status",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09155",
    "question": "What is associated with Pigment incontinence?",
    "seeds": [
      "Pigment incontinence"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09156",
    "question": "What is associated with Mild hemophilia A?",
    "seeds": [
      "Mild hemophilia A"
    ],
    "gold_answer": "F8",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09157",
    "question": "What is associated with Celiac disease, susceptibility to, 1?",
    "seeds": [
      "Celiac disease, susceptibility to, 1"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09158",
    "question": "What is associated with Abnormal natural killer cell morphology?",
    "seeds": [
      "Abnormal natural killer cell morphology"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09159",
    "question": "What is associated with Progressive supranuclear palsy-progressive non-fluent aphasia syndrome?",
    "seeds": [
      "Progressive supranuclear palsy-progressive non-fluent aphasia syndrome"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09160",
    "question": "What phenotype is associated with Episodic ataxia, type 8?",
    "seeds": [
      "Episodic ataxia, type 8"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09161",
    "question": "What is associated with Rib gap?",
    "seeds": [
      "Rib gap"
    ],
    "gold_answer": "Abnormal rib morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09162",
    "question": "What is associated with Joubert syndrome 9?",
    "seeds": [
      "Joubert syndrome 9"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09163",
    "question": "What is associated with Intra-epidermal blistering?",
    "seeds": [
      "Intra-epidermal blistering"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09164",
    "question": "What is associated with Hypopigmentation-punctate palmoplantar keratoderma syndrome?",
    "seeds": [
      "Hypopigmentation-punctate palmoplantar keratoderma syndrome"
    ],
    "gold_answer": "ENPP1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09165",
    "question": "What is associated with Optic disc coloboma?",
    "seeds": [
      "Optic disc coloboma"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09166",
    "question": "What phenotype is associated with Microcephaly, epilepsy, and diabetes syndrome 2?",
    "seeds": [
      "Microcephaly, epilepsy, and diabetes syndrome 2"
    ],
    "gold_answer": "Bilateral tonic-clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09167",
    "question": "What is associated with Nasal mucosa vasculitis?",
    "seeds": [
      "Nasal mucosa vasculitis"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09168",
    "question": "What is associated with Cutis laxa, autosomal recessive, type IIB?",
    "seeds": [
      "Cutis laxa, autosomal recessive, type IIB"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09169",
    "question": "What is associated with Osteogenesis imperfecta, type VI?",
    "seeds": [
      "Osteogenesis imperfecta, type VI"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09170",
    "question": "What is associated with Spinocerebellar ataxia 31?",
    "seeds": [
      "Spinocerebellar ataxia 31"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09171",
    "question": "What is associated with Aplasia/Hypoplasia of the vertebrae?",
    "seeds": [
      "Aplasia/Hypoplasia of the vertebrae"
    ],
    "gold_answer": "Aplasia/hypoplasia involving the skeleton",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09172",
    "question": "What is associated with Prolonged bleeding time?",
    "seeds": [
      "Prolonged bleeding time"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09173",
    "question": "What is associated with Macrophthalmia, colobomatous, with microcornea?",
    "seeds": [
      "Macrophthalmia, colobomatous, with microcornea"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09174",
    "question": "What is associated with Decreased muscle caveolin-3 level?",
    "seeds": [
      "Decreased muscle caveolin-3 level"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09175",
    "question": "What is associated with Hyperextensible skin of chest?",
    "seeds": [
      "Hyperextensible skin of chest"
    ],
    "gold_answer": "Focal hyperextensible skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09176",
    "question": "What is associated with Irregular epiphysis of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Irregular epiphysis of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Irregular epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09177",
    "question": "What is associated with Mesenteric torsion?",
    "seeds": [
      "Mesenteric torsion"
    ],
    "gold_answer": "Abnormal mesentery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09178",
    "question": "What is associated with Deja vu aura?",
    "seeds": [
      "Deja vu aura"
    ],
    "gold_answer": "Psychic epileptic aura",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09179",
    "question": "What is associated with Yellow-brown discoloration of the teeth?",
    "seeds": [
      "Yellow-brown discoloration of the teeth"
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09180",
    "question": "What is associated with Dust particle inclusion in alveolar macrophages?",
    "seeds": [
      "Dust particle inclusion in alveolar macrophages"
    ],
    "gold_answer": "Abnormal cellular composition of bronchoalveolar fluid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09181",
    "question": "What is associated with Megalencephaly with dysmyelination?",
    "seeds": [
      "Megalencephaly with dysmyelination"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09182",
    "question": "What phenotype is associated with Deafness, autosomal recessive 115?",
    "seeds": [
      "Deafness, autosomal recessive 115"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09183",
    "question": "What phenotype is associated with Congenital alopecia totalis?",
    "seeds": [
      "Congenital alopecia totalis"
    ],
    "gold_answer": "Fragile nails",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09184",
    "question": "What phenotype is associated with Cornelia de Lange syndrome 3?",
    "seeds": [
      "Cornelia de Lange syndrome 3"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09185",
    "question": "What is associated with Oligoclonal elevation of circulating IgM?",
    "seeds": [
      "Oligoclonal elevation of circulating IgM"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09186",
    "question": "What is associated with 10q22.3q23.3 microduplication syndrome?",
    "seeds": [
      "10q22.3q23.3 microduplication syndrome"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09187",
    "question": "What is associated with Auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome?",
    "seeds": [
      "Auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09188",
    "question": "What is associated with Muscular ventricular septal defect?",
    "seeds": [
      "Muscular ventricular septal defect"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09189",
    "question": "What is associated with Distal 5th toe symphalangism?",
    "seeds": [
      "Distal 5th toe symphalangism"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09190",
    "question": "What is associated with Maternal uniparental disomy of chromosome X syndrome?",
    "seeds": [
      "Maternal uniparental disomy of chromosome X syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09191",
    "question": "What phenotype is associated with Diarrhea 13?",
    "seeds": [
      "Diarrhea 13"
    ],
    "gold_answer": "Recurrent hypoglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09192",
    "question": "What is associated with Urethral stricture?",
    "seeds": [
      "Urethral stricture"
    ],
    "gold_answer": "Urethral obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09193",
    "question": "What is associated with Corticospinal tract atrophy?",
    "seeds": [
      "Corticospinal tract atrophy"
    ],
    "gold_answer": "Atrophy/Degeneration involving the corticospinal tracts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09194",
    "question": "What is associated with Abnormal caudate nucleus morphology?",
    "seeds": [
      "Abnormal caudate nucleus morphology"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09195",
    "question": "What is associated with Elevated urinary thymine level?",
    "seeds": [
      "Elevated urinary thymine level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09196",
    "question": "What is associated with Generalized bone demineralization?",
    "seeds": [
      "Generalized bone demineralization"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09197",
    "question": "What phenotype is associated with 3-methylglutaconic aciduria type 9?",
    "seeds": [
      "3-methylglutaconic aciduria type 9"
    ],
    "gold_answer": "3-Methylglutaconic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09198",
    "question": "What is associated with Arthrogryposis multiplex congenita with whistling face?",
    "seeds": [
      "Arthrogryposis multiplex congenita with whistling face"
    ],
    "gold_answer": "Abnormality of mouth shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09199",
    "question": "What is associated with Paroxysmal cold hemoglobinuria?",
    "seeds": [
      "Paroxysmal cold hemoglobinuria"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09200",
    "question": "What is associated with Paroxysmal non-kinesigenic dyskinesia?",
    "seeds": [
      "Paroxysmal non-kinesigenic dyskinesia"
    ],
    "gold_answer": "Abnormal neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09201",
    "question": "What is associated with Asymmetry of the breasts?",
    "seeds": [
      "Asymmetry of the breasts"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09202",
    "question": "What is associated with Muscle fiber actin filament accumulation?",
    "seeds": [
      "Muscle fiber actin filament accumulation"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09203",
    "question": "What is associated with Jaw swelling?",
    "seeds": [
      "Jaw swelling"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09204",
    "question": "What is associated with Complex renal cyst?",
    "seeds": [
      "Complex renal cyst"
    ],
    "gold_answer": "Renal cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09205",
    "question": "What is associated with EEG with generalized epileptiform discharges?",
    "seeds": [
      "EEG with generalized epileptiform discharges"
    ],
    "gold_answer": "Interictal EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09206",
    "question": "What is associated with Neoplasm of the genitourinary tract?",
    "seeds": [
      "Neoplasm of the genitourinary tract"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09207",
    "question": "What is associated with Athabaskan brainstem dysgenesis syndrome?",
    "seeds": [
      "Athabaskan brainstem dysgenesis syndrome"
    ],
    "gold_answer": "Hypoventilation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09208",
    "question": "What is associated with Pear-shaped nose?",
    "seeds": [
      "Pear-shaped nose"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09209",
    "question": "What phenotype is associated with Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency?",
    "seeds": [
      "Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency"
    ],
    "gold_answer": "Hemolytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09210",
    "question": "What is associated with Intraretinal hemorrhage?",
    "seeds": [
      "Intraretinal hemorrhage"
    ],
    "gold_answer": "Retinal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09211",
    "question": "What is associated with Anterior synechiae of the anterior chamber?",
    "seeds": [
      "Anterior synechiae of the anterior chamber"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09212",
    "question": "What is associated with Epiphyseal stippling of finger phalanges?",
    "seeds": [
      "Epiphyseal stippling of finger phalanges"
    ],
    "gold_answer": "Abnormal hand bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09213",
    "question": "What is associated with Abnormal synovial cavity morphology?",
    "seeds": [
      "Abnormal synovial cavity morphology"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09214",
    "question": "What phenotype is associated with Tumor predisposition syndrome 2?",
    "seeds": [
      "Tumor predisposition syndrome 2"
    ],
    "gold_answer": "Colon cancer",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09215",
    "question": "What is associated with Dermatitis herpetiformis, familial?",
    "seeds": [
      "Dermatitis herpetiformis, familial"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09216",
    "question": "What is associated with Binasal hemianopia?",
    "seeds": [
      "Binasal hemianopia"
    ],
    "gold_answer": "Hemianopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09217",
    "question": "What phenotype is associated with Cutis laxa, autosomal recessive, type IID?",
    "seeds": [
      "Cutis laxa, autosomal recessive, type IID"
    ],
    "gold_answer": "Ventricular septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09218",
    "question": "What is associated with Porokeratosis 6, disseminated superficial Actinic type?",
    "seeds": [
      "Porokeratosis 6, disseminated superficial Actinic type"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09219",
    "question": "What is associated with Abnormal oral mucosa morphology?",
    "seeds": [
      "Abnormal oral mucosa morphology"
    ],
    "gold_answer": "Abnormality of the mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09220",
    "question": "What is associated with Chromosome 2q37 deletion syndrome?",
    "seeds": [
      "Chromosome 2q37 deletion syndrome"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09221",
    "question": "What is associated with Osteoglophonic dysplasia?",
    "seeds": [
      "Osteoglophonic dysplasia"
    ],
    "gold_answer": "Abnormal neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09222",
    "question": "What is associated with Osteogenesis imperfecta type 2?",
    "seeds": [
      "Osteogenesis imperfecta type 2"
    ],
    "gold_answer": "PPIB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09223",
    "question": "What is associated with Iliac vein compression?",
    "seeds": [
      "Iliac vein compression"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09224",
    "question": "What is associated with Scrotal hyperpigmentation?",
    "seeds": [
      "Scrotal hyperpigmentation"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09225",
    "question": "What is associated with Kaposiform hemangioendothelioma?",
    "seeds": [
      "Kaposiform hemangioendothelioma"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09226",
    "question": "What phenotype is associated with Immunodeficiency 15?",
    "seeds": [
      "Immunodeficiency 15"
    ],
    "gold_answer": "Reduced total natural killer cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09227",
    "question": "What is associated with Lactic acidosis, chronic adult form?",
    "seeds": [
      "Lactic acidosis, chronic adult form"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09228",
    "question": "What is associated with Unusual infection?",
    "seeds": [
      "Unusual infection"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09229",
    "question": "What is associated with Short 3rd metacarpal?",
    "seeds": [
      "Short 3rd metacarpal"
    ],
    "gold_answer": "Abnormal 3rd metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09230",
    "question": "What is associated with Distal ulnar epiphyseal stippling?",
    "seeds": [
      "Distal ulnar epiphyseal stippling"
    ],
    "gold_answer": "Abnormal ulnar epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09231",
    "question": "What is associated with Elevated circulating growth hormone concentration?",
    "seeds": [
      "Elevated circulating growth hormone concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09232",
    "question": "What is associated with Macular dystrophy, butterfly-shaped pigmentary, 2?",
    "seeds": [
      "Macular dystrophy, butterfly-shaped pigmentary, 2"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09233",
    "question": "What is associated with Benign hereditary chorea?",
    "seeds": [
      "Benign hereditary chorea"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09234",
    "question": "What is associated with Tented philtrum?",
    "seeds": [
      "Tented philtrum"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09235",
    "question": "What is associated with Focal aware pedal automatism seizure?",
    "seeds": [
      "Focal aware pedal automatism seizure"
    ],
    "gold_answer": "Focal automatism seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09236",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic 27?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic 27"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09237",
    "question": "What is associated with Distal lower limb muscle weakness?",
    "seeds": [
      "Distal lower limb muscle weakness"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09238",
    "question": "What is associated with Abnormal circulating potassium concentration?",
    "seeds": [
      "Abnormal circulating potassium concentration"
    ],
    "gold_answer": "Abnormal blood ion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09239",
    "question": "What phenotype is associated with Tetraploidy syndrome?",
    "seeds": [
      "Tetraploidy syndrome"
    ],
    "gold_answer": "Cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09240",
    "question": "What is associated with Atelis syndrome 2?",
    "seeds": [
      "Atelis syndrome 2"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09241",
    "question": "What is associated with Abnormal brain creatine level by MRS?",
    "seeds": [
      "Abnormal brain creatine level by MRS"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09242",
    "question": "What is associated with Flattened epiphysis?",
    "seeds": [
      "Flattened epiphysis"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09243",
    "question": "What phenotype is associated with Peroxisome biogenesis disorder 13A (Zellweger)?",
    "seeds": [
      "Peroxisome biogenesis disorder 13A (Zellweger)"
    ],
    "gold_answer": "Dolichocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09244",
    "question": "What is associated with Maceration?",
    "seeds": [
      "Maceration"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09245",
    "question": "What is associated with Abnormal response to ACTH stimulation test?",
    "seeds": [
      "Abnormal response to ACTH stimulation test"
    ],
    "gold_answer": "Abnormal endocrine physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09246",
    "question": "What is associated with Absent epiphysis of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Absent epiphysis of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Absent epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09247",
    "question": "What is associated with Abnormal blood cation concentration?",
    "seeds": [
      "Abnormal blood cation concentration"
    ],
    "gold_answer": "Abnormal blood ion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09248",
    "question": "What is associated with Pituitary gonadotropic cell adenoma?",
    "seeds": [
      "Pituitary gonadotropic cell adenoma"
    ],
    "gold_answer": "Neoplasm of the pituitary gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09249",
    "question": "What phenotype is associated with Cataract, crystalline aculeiform?",
    "seeds": [
      "Cataract, crystalline aculeiform"
    ],
    "gold_answer": "Developmental cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09250",
    "question": "What is associated with Displaced anterior fontanelle?",
    "seeds": [
      "Displaced anterior fontanelle"
    ],
    "gold_answer": "Abnormal cranial suture/fontanelle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09251",
    "question": "What is associated with Recurrent Staphylococcus aureus infections?",
    "seeds": [
      "Recurrent Staphylococcus aureus infections"
    ],
    "gold_answer": "Recurrent bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09252",
    "question": "What is associated with Abnormal pulmonary valve physiology?",
    "seeds": [
      "Abnormal pulmonary valve physiology"
    ],
    "gold_answer": "Abnormal heart valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09253",
    "question": "What is associated with Neurodevelopmental disorder with speech delay and behavioral abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with speech delay and behavioral abnormalities"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09254",
    "question": "What is associated with Joubert syndrome 16?",
    "seeds": [
      "Joubert syndrome 16"
    ],
    "gold_answer": "Cerebellar cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09255",
    "question": "What is associated with Anterior rib cupping?",
    "seeds": [
      "Anterior rib cupping"
    ],
    "gold_answer": "Cupped ribs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09256",
    "question": "What is associated with Reduced quantity of Von Willebrand factor?",
    "seeds": [
      "Reduced quantity of Von Willebrand factor"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09257",
    "question": "What phenotype is associated with Distal hereditary motor neuropathy type 5?",
    "seeds": [
      "Distal hereditary motor neuropathy type 5"
    ],
    "gold_answer": "First dorsal interossei muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09258",
    "question": "What is associated with Abnormality of skin adnexa physiology?",
    "seeds": [
      "Abnormality of skin adnexa physiology"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09259",
    "question": "What is associated with Malar flattening?",
    "seeds": [
      "Malar flattening"
    ],
    "gold_answer": "Abnormal zygomatic bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09260",
    "question": "What is associated with Laryngeal cleft?",
    "seeds": [
      "Laryngeal cleft"
    ],
    "gold_answer": "Abnormal larynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09261",
    "question": "What is associated with Cardiomyopathy, dilated, 1QQ?",
    "seeds": [
      "Cardiomyopathy, dilated, 1QQ"
    ],
    "gold_answer": "Abnormal left ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09262",
    "question": "What is associated with Febrile seizure outside the age of 3 months to 6 years?",
    "seeds": [
      "Febrile seizure outside the age of 3 months to 6 years"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09263",
    "question": "What is associated with Clumping of elastic fibers in the dermis?",
    "seeds": [
      "Clumping of elastic fibers in the dermis"
    ],
    "gold_answer": "Abnormal cutaneous elastic fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09264",
    "question": "What is associated with Hemochromatosis, type 3?",
    "seeds": [
      "Hemochromatosis, type 3"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09265",
    "question": "What is associated with Autosomal spastic paraplegia type 30?",
    "seeds": [
      "Autosomal spastic paraplegia type 30"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09266",
    "question": "What is associated with Myopathic Ehlers-Danlos syndrome?",
    "seeds": [
      "Myopathic Ehlers-Danlos syndrome"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09267",
    "question": "What is associated with Conjunctival papillae?",
    "seeds": [
      "Conjunctival papillae"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09268",
    "question": "What is associated with Multifocal neonatal sequential seizure?",
    "seeds": [
      "Multifocal neonatal sequential seizure"
    ],
    "gold_answer": "Neonatal electro-clinical seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09269",
    "question": "What phenotype is associated with Neurodevelopmental disorder with language impairment and behavioral abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with language impairment and behavioral abnormalities"
    ],
    "gold_answer": "Self-injurious behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09270",
    "question": "What is associated with Bullet-shaped distal phalanges of the hand?",
    "seeds": [
      "Bullet-shaped distal phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09271",
    "question": "What is associated with Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome?",
    "seeds": [
      "Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome"
    ],
    "gold_answer": "Premature ventricular contraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09272",
    "question": "What is associated with Clinodactyly of the 2nd toe?",
    "seeds": [
      "Clinodactyly of the 2nd toe"
    ],
    "gold_answer": "Abnormal second toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09273",
    "question": "What phenotype is associated with Locked-in syndrome?",
    "seeds": [
      "Locked-in syndrome"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09274",
    "question": "What is associated with Congenital cataracts, facial dysmorphism, and neuropathy?",
    "seeds": [
      "Congenital cataracts, facial dysmorphism, and neuropathy"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09275",
    "question": "What is associated with White forelock?",
    "seeds": [
      "White forelock"
    ],
    "gold_answer": "Patchy hypopigmentation of hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09276",
    "question": "What is associated with Lower extremity subcutanous fat hypertrophy?",
    "seeds": [
      "Lower extremity subcutanous fat hypertrophy"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09277",
    "question": "What is associated with Aortic valve calcification?",
    "seeds": [
      "Aortic valve calcification"
    ],
    "gold_answer": "Cardiovascular calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09278",
    "question": "What phenotype is associated with RAPADILINO syndrome?",
    "seeds": [
      "RAPADILINO syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the patella",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09279",
    "question": "What phenotype is associated with Central incisors, absence of?",
    "seeds": [
      "Central incisors, absence of"
    ],
    "gold_answer": "Agenesis of central incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09280",
    "question": "What is associated with Fibrodysplasia ossificans progressiva?",
    "seeds": [
      "Fibrodysplasia ossificans progressiva"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09281",
    "question": "What is associated with Single coronary artery origin?",
    "seeds": [
      "Single coronary artery origin"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09282",
    "question": "What is associated with Moderate hearing impairment?",
    "seeds": [
      "Moderate hearing impairment"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09283",
    "question": "What is associated with Supernumerary tracheal bronchus?",
    "seeds": [
      "Supernumerary tracheal bronchus"
    ],
    "gold_answer": "Abnormal bronchus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09284",
    "question": "What is associated with Anti-Mi2 antibody positivity?",
    "seeds": [
      "Anti-Mi2 antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09285",
    "question": "What is associated with APUdoma?",
    "seeds": [
      "APUdoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09286",
    "question": "What is associated with Hypoplastic areola?",
    "seeds": [
      "Hypoplastic areola"
    ],
    "gold_answer": "Abnormal areolar morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09287",
    "question": "What is associated with Glomerular hyaline subepithelial deposits?",
    "seeds": [
      "Glomerular hyaline subepithelial deposits"
    ],
    "gold_answer": "Glomerular deposits",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09288",
    "question": "What is associated with Autosomal dominant intellectual disability-craniofacial dysmorphism-macrocephaly-hypotonia syndrome due to H1-4 mutation?",
    "seeds": [
      "Autosomal dominant intellectual disability-craniofacial dysmorphism-macrocephaly-hypotonia syndrome due to H1-4 mutation"
    ],
    "gold_answer": "H1-4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09289",
    "question": "What is associated with Bracket epiphysis of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Bracket epiphysis of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09290",
    "question": "What is associated with Amyloidosis, primary localized cutaneous, 3?",
    "seeds": [
      "Amyloidosis, primary localized cutaneous, 3"
    ],
    "gold_answer": "Macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09291",
    "question": "What is associated with 46,XX difference of sex development-skeletal anomalies syndrome?",
    "seeds": [
      "46,XX difference of sex development-skeletal anomalies syndrome"
    ],
    "gold_answer": "Abnormality of the humeroradial joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09292",
    "question": "What is associated with Axial dystonia?",
    "seeds": [
      "Axial dystonia"
    ],
    "gold_answer": "Dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09293",
    "question": "What is associated with Decreased FOXP3-expressing T cell count?",
    "seeds": [
      "Decreased FOXP3-expressing T cell count"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09294",
    "question": "What is associated with Avoidance of stimuli associated with traumatic event?",
    "seeds": [
      "Avoidance of stimuli associated with traumatic event"
    ],
    "gold_answer": "Abnormal fear-induced behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09295",
    "question": "What is associated with Cerebral degeneration?",
    "seeds": [
      "Cerebral degeneration"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09296",
    "question": "What is associated with Radiation proctitis?",
    "seeds": [
      "Radiation proctitis"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09297",
    "question": "What is associated with Spinocerebellar ataxia type 32?",
    "seeds": [
      "Spinocerebellar ataxia type 32"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09298",
    "question": "What phenotype is associated with Muscular dystrophy, congenital, with cataracts and intellectual disability?",
    "seeds": [
      "Muscular dystrophy, congenital, with cataracts and intellectual disability"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09299",
    "question": "What is associated with Difficulty floating in water?",
    "seeds": [
      "Difficulty floating in water"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09300",
    "question": "What is associated with Formiminotransferase deficiency?",
    "seeds": [
      "Formiminotransferase deficiency"
    ],
    "gold_answer": "Abnormal circulating phenylalanine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09301",
    "question": "What is associated with Peripapillary exudate?",
    "seeds": [
      "Peripapillary exudate"
    ],
    "gold_answer": "Retinal exudate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09302",
    "question": "What is associated with Anti-desmoglein-3 antibody positivity?",
    "seeds": [
      "Anti-desmoglein-3 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09303",
    "question": "What is associated with Abnormal erythrocyte adenosine deaminase activity?",
    "seeds": [
      "Abnormal erythrocyte adenosine deaminase activity"
    ],
    "gold_answer": "Abnormal erythrocyte enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09304",
    "question": "What phenotype is associated with Deafness, autosomal dominant 3B?",
    "seeds": [
      "Deafness, autosomal dominant 3B"
    ],
    "gold_answer": "Adult onset sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09305",
    "question": "What is associated with Abnormal branching pattern of the aortic arch?",
    "seeds": [
      "Abnormal branching pattern of the aortic arch"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09306",
    "question": "What is associated with Abnormality of intrinsic muscle of tongue?",
    "seeds": [
      "Abnormality of intrinsic muscle of tongue"
    ],
    "gold_answer": "Abnormality of the tongue muscle",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09307",
    "question": "What phenotype is associated with Dyskeratosis congenita, autosomal dominant 3?",
    "seeds": [
      "Dyskeratosis congenita, autosomal dominant 3"
    ],
    "gold_answer": "Esophageal stricture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09308",
    "question": "What is associated with Hyperconvex nail?",
    "seeds": [
      "Hyperconvex nail"
    ],
    "gold_answer": "Nail dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09309",
    "question": "What is associated with Elevated urinary 3-aminoisobutyric acid?",
    "seeds": [
      "Elevated urinary 3-aminoisobutyric acid"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09310",
    "question": "What is associated with Bartter syndrome type 5?",
    "seeds": [
      "Bartter syndrome type 5"
    ],
    "gold_answer": "MAGED2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09311",
    "question": "What is associated with Supraumbilical raphe?",
    "seeds": [
      "Supraumbilical raphe"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09312",
    "question": "What is associated with Secondary vesicoureteral reflux?",
    "seeds": [
      "Secondary vesicoureteral reflux"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09313",
    "question": "What is associated with Closed fracture?",
    "seeds": [
      "Closed fracture"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09314",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 24?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 24"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09315",
    "question": "What is associated with Acute disseminated encephalomyelitis?",
    "seeds": [
      "Acute disseminated encephalomyelitis"
    ],
    "gold_answer": "Infection following live vaccination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09316",
    "question": "What is associated with Abnormal Esterman grid perimetry test?",
    "seeds": [
      "Abnormal Esterman grid perimetry test"
    ],
    "gold_answer": "Abnormal static automated perimetry test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09317",
    "question": "What is associated with Urethral fistula?",
    "seeds": [
      "Urethral fistula"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09318",
    "question": "What is associated with Delta-beta-thalassemia?",
    "seeds": [
      "Delta-beta-thalassemia"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09319",
    "question": "What is associated with Myopia 28, autosomal recessive?",
    "seeds": [
      "Myopia 28, autosomal recessive"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09320",
    "question": "What is associated with Abnormal distal toe phalanx morphology?",
    "seeds": [
      "Abnormal distal toe phalanx morphology"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09321",
    "question": "What is associated with 46,XX sex reversal 2?",
    "seeds": [
      "46,XX sex reversal 2"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09322",
    "question": "What is associated with Triangular epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Triangular epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Triangular epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09323",
    "question": "What is associated with Intellectual developmental disorder, X-linked syndromic, Claes-Jensen type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic, Claes-Jensen type"
    ],
    "gold_answer": "Abnormal tongue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09324",
    "question": "What is associated with Tibial arterial calcification?",
    "seeds": [
      "Tibial arterial calcification"
    ],
    "gold_answer": "Arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09325",
    "question": "What is associated with Cholestasis, progressive familial intrahepatic 1?",
    "seeds": [
      "Cholestasis, progressive familial intrahepatic 1"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09326",
    "question": "What phenotype is associated with Chromosome 22q13 duplication syndrome?",
    "seeds": [
      "Chromosome 22q13 duplication syndrome"
    ],
    "gold_answer": "Upslanted palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09327",
    "question": "What is associated with Extraskeletal Ewing sarcoma?",
    "seeds": [
      "Extraskeletal Ewing sarcoma"
    ],
    "gold_answer": "FLI1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_09328",
    "question": "What is associated with Hypoplastic pelvis?",
    "seeds": [
      "Hypoplastic pelvis"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09329",
    "question": "What is associated with ISPD-related limb-girdle muscular dystrophy R20?",
    "seeds": [
      "ISPD-related limb-girdle muscular dystrophy R20"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09330",
    "question": "What is associated with Elevated CSF apolipoprotein B concentration?",
    "seeds": [
      "Elevated CSF apolipoprotein B concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09331",
    "question": "What is associated with Discontinuous ascending root of helix?",
    "seeds": [
      "Discontinuous ascending root of helix"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09332",
    "question": "What is associated with GM1-gangliosidosis, type II?",
    "seeds": [
      "GM1-gangliosidosis, type II"
    ],
    "gold_answer": "Brain atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09333",
    "question": "What phenotype is associated with Microphthalmia, syndromic 7?",
    "seeds": [
      "Microphthalmia, syndromic 7"
    ],
    "gold_answer": "Premature birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09334",
    "question": "What is associated with Abnormal hair whorl?",
    "seeds": [
      "Abnormal hair whorl"
    ],
    "gold_answer": "Congenital abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09335",
    "question": "What is associated with Transient hypophosphatemia?",
    "seeds": [
      "Transient hypophosphatemia"
    ],
    "gold_answer": "Abnormal blood phosphate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09336",
    "question": "What is associated with Elevated circulating 3-hydroxyanthranilic acid concentration?",
    "seeds": [
      "Elevated circulating 3-hydroxyanthranilic acid concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09337",
    "question": "What is associated with Right ventricular regional dyskinesia?",
    "seeds": [
      "Right ventricular regional dyskinesia"
    ],
    "gold_answer": "Abnormal right ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09338",
    "question": "What is associated with Short proximal phalanx of the 5th toe?",
    "seeds": [
      "Short proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Absent toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09339",
    "question": "What is associated with Right atrial enlargement?",
    "seeds": [
      "Right atrial enlargement"
    ],
    "gold_answer": "Abnormal cardiac atrium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09340",
    "question": "What is associated with Flatulence?",
    "seeds": [
      "Flatulence"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09341",
    "question": "What phenotype is associated with Hyper-IgE recurrent infection syndrome?",
    "seeds": [
      "Hyper-IgE recurrent infection syndrome"
    ],
    "gold_answer": "Abnormal toenail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09342",
    "question": "What is associated with Polymorphic and polytopic ventricular extrasystoles?",
    "seeds": [
      "Polymorphic and polytopic ventricular extrasystoles"
    ],
    "gold_answer": "Ventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09343",
    "question": "What is associated with Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal?",
    "seeds": [
      "Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal"
    ],
    "gold_answer": "Abnormality of the plantar skin of foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09344",
    "question": "What is associated with Positive brain-tissue rabies nucleic acid test?",
    "seeds": [
      "Positive brain-tissue rabies nucleic acid test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09345",
    "question": "What is associated with Cone-shaped epiphysis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Cone-shaped epiphysis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Phalangeal cone-shaped epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09346",
    "question": "What is associated with Anti-parotid secretory protein antibody positivity?",
    "seeds": [
      "Anti-parotid secretory protein antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09347",
    "question": "What phenotype is associated with Heart-hand syndrome, Slovenian type?",
    "seeds": [
      "Heart-hand syndrome, Slovenian type"
    ],
    "gold_answer": "Aplasia of the middle phalanx of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09348",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 41?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 41"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09349",
    "question": "What is associated with Arcuate artery intima/media granulomatous arteriitis?",
    "seeds": [
      "Arcuate artery intima/media granulomatous arteriitis"
    ],
    "gold_answer": "Abnormal arcuate artery intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09350",
    "question": "What is associated with Autism susceptibility 1?",
    "seeds": [
      "Autism susceptibility 1"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09351",
    "question": "What is associated with Autism spectrum disorder due to AUTS2 deficiency?",
    "seeds": [
      "Autism spectrum disorder due to AUTS2 deficiency"
    ],
    "gold_answer": "Abnormal nostril morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09352",
    "question": "What is associated with Fragmented sleep?",
    "seeds": [
      "Fragmented sleep"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09353",
    "question": "What is associated with Abnormality of the pancreas?",
    "seeds": [
      "Abnormality of the pancreas"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09354",
    "question": "What is associated with Grade II vesicoureteral reflux?",
    "seeds": [
      "Grade II vesicoureteral reflux"
    ],
    "gold_answer": "Vesicoureteral reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09355",
    "question": "What is associated with Small epiphyses of the 3rd finger?",
    "seeds": [
      "Small epiphyses of the 3rd finger"
    ],
    "gold_answer": "Small epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09356",
    "question": "What is associated with Abnormal sarcomere morphology?",
    "seeds": [
      "Abnormal sarcomere morphology"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09357",
    "question": "What phenotype is associated with Microcephaly and chorioretinopathy, autosomal recessive, 2?",
    "seeds": [
      "Microcephaly and chorioretinopathy, autosomal recessive, 2"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09358",
    "question": "What is associated with Abnormality of frontal process of maxilla?",
    "seeds": [
      "Abnormality of frontal process of maxilla"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09359",
    "question": "What is associated with Wrist pain?",
    "seeds": [
      "Wrist pain"
    ],
    "gold_answer": "Upper limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09360",
    "question": "What is associated with Alsahan-Harris syndrome?",
    "seeds": [
      "Alsahan-Harris syndrome"
    ],
    "gold_answer": "Disproportionate short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09361",
    "question": "What phenotype is associated with Epilepsy idiopathic generalized, susceptibility to, 8?",
    "seeds": [
      "Epilepsy idiopathic generalized, susceptibility to, 8"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09362",
    "question": "What is associated with Telangiectases producing 'marbled' skin?",
    "seeds": [
      "Telangiectases producing 'marbled' skin"
    ],
    "gold_answer": "Telangiectasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09363",
    "question": "What is associated with Syndactyly, mesoaxial synostotic, with phalangeal reduction?",
    "seeds": [
      "Syndactyly, mesoaxial synostotic, with phalangeal reduction"
    ],
    "gold_answer": "Abnormality of the phalanges of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09364",
    "question": "What is associated with Multifocal epileptiform discharges?",
    "seeds": [
      "Multifocal epileptiform discharges"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09365",
    "question": "What is associated with Shield chest?",
    "seeds": [
      "Shield chest"
    ],
    "gold_answer": "Enlarged thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09366",
    "question": "What phenotype is associated with Hydroxykynureninuria?",
    "seeds": [
      "Hydroxykynureninuria"
    ],
    "gold_answer": "Headache",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09367",
    "question": "What is associated with Mesangial matrix expansion?",
    "seeds": [
      "Mesangial matrix expansion"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09368",
    "question": "What is associated with Hepatocellular adenoma?",
    "seeds": [
      "Hepatocellular adenoma"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09369",
    "question": "What phenotype is associated with Marfanoid habitus-autosomal recessive intellectual disability syndrome?",
    "seeds": [
      "Marfanoid habitus-autosomal recessive intellectual disability syndrome"
    ],
    "gold_answer": "Broad philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09370",
    "question": "What is associated with Optic nerve glioma?",
    "seeds": [
      "Optic nerve glioma"
    ],
    "gold_answer": "Glioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09371",
    "question": "What is associated with Diffuse cerebral atrophy?",
    "seeds": [
      "Diffuse cerebral atrophy"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09372",
    "question": "What is associated with Rajab interstitial lung disease with brain calcifications 2?",
    "seeds": [
      "Rajab interstitial lung disease with brain calcifications 2"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09373",
    "question": "What is associated with Pelvic organ prolapse?",
    "seeds": [
      "Pelvic organ prolapse"
    ],
    "gold_answer": "Abnormal large intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09374",
    "question": "What is associated with Diarrhea 9?",
    "seeds": [
      "Diarrhea 9"
    ],
    "gold_answer": "Abnormal small intestinal mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09375",
    "question": "What is associated with Central retinal vessel vascular tortuosity?",
    "seeds": [
      "Central retinal vessel vascular tortuosity"
    ],
    "gold_answer": "Retinal arterial tortuosity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09376",
    "question": "What is associated with Aplasia/Hypoplasia involving the corticospinal tracts?",
    "seeds": [
      "Aplasia/Hypoplasia involving the corticospinal tracts"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09377",
    "question": "What is associated with Abnormality of renal excretion?",
    "seeds": [
      "Abnormality of renal excretion"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09378",
    "question": "What phenotype is associated with Fragile site 16q22?",
    "seeds": [
      "Fragile site 16q22"
    ],
    "gold_answer": "Infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09379",
    "question": "What is associated with Abnormal visual field test?",
    "seeds": [
      "Abnormal visual field test"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09380",
    "question": "What is associated with EEG with generalized spikes?",
    "seeds": [
      "EEG with generalized spikes"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09381",
    "question": "What is associated with 48,XYYY syndrome?",
    "seeds": [
      "48,XYYY syndrome"
    ],
    "gold_answer": "Impairment in personality functioning",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09382",
    "question": "What phenotype is associated with Martsolf syndrome 1?",
    "seeds": [
      "Martsolf syndrome 1"
    ],
    "gold_answer": "Constipation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09383",
    "question": "What is associated with Abnormal pelvic girdle bone morphology?",
    "seeds": [
      "Abnormal pelvic girdle bone morphology"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09384",
    "question": "What is associated with Local paresthesia at bite site?",
    "seeds": [
      "Local paresthesia at bite site"
    ],
    "gold_answer": "Paresthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09385",
    "question": "What is associated with Ivory epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Ivory epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Ivory epiphyses of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09386",
    "question": "What is associated with PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome?",
    "seeds": [
      "PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome"
    ],
    "gold_answer": "Abnormality of the philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09387",
    "question": "What is associated with Neurodevelopmental disorder with progressive spasticity and brain abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with progressive spasticity and brain abnormalities"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09388",
    "question": "What is associated with Deficient ossification of hand bones?",
    "seeds": [
      "Deficient ossification of hand bones"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09389",
    "question": "What is associated with Polydactyly, postaxial, types A1 and B?",
    "seeds": [
      "Polydactyly, postaxial, types A1 and B"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09390",
    "question": "What is associated with Ichthyosis, congenital, autosomal recessive 4B?",
    "seeds": [
      "Ichthyosis, congenital, autosomal recessive 4B"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09391",
    "question": "What is associated with Insulin autoimmune syndrome?",
    "seeds": [
      "Insulin autoimmune syndrome"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09392",
    "question": "What phenotype is associated with Early infantile developmental and epileptic encephalopathy?",
    "seeds": [
      "Early infantile developmental and epileptic encephalopathy"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09393",
    "question": "What is associated with Abnormal protein N-linked glycosylation?",
    "seeds": [
      "Abnormal protein N-linked glycosylation"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09394",
    "question": "What phenotype is associated with Immunodeficiency 88?",
    "seeds": [
      "Immunodeficiency 88"
    ],
    "gold_answer": "Increased total eosinophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09395",
    "question": "What is associated with Cenani-Lenz syndrome?",
    "seeds": [
      "Cenani-Lenz syndrome"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09396",
    "question": "What is associated with Premature coronary artery atherosclerosis?",
    "seeds": [
      "Premature coronary artery atherosclerosis"
    ],
    "gold_answer": "Arteriosclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09397",
    "question": "What is associated with Olmsted syndrome 2?",
    "seeds": [
      "Olmsted syndrome 2"
    ],
    "gold_answer": "Palmar hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09398",
    "question": "What is associated with Cartilaginous ossification of nose?",
    "seeds": [
      "Cartilaginous ossification of nose"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09399",
    "question": "What is associated with Microcephaly-seizures-intellectual disability-heart disease syndrome?",
    "seeds": [
      "Microcephaly-seizures-intellectual disability-heart disease syndrome"
    ],
    "gold_answer": "Esodeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09400",
    "question": "What phenotype is associated with Epidermolysis bullosa simplex 1D, generalized, intermediate or severe, autosomal recessive?",
    "seeds": [
      "Epidermolysis bullosa simplex 1D, generalized, intermediate or severe, autosomal recessive"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09401",
    "question": "What is associated with Hypertropia?",
    "seeds": [
      "Hypertropia"
    ],
    "gold_answer": "Hyperdeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09402",
    "question": "What is associated with Elevated circulating thymine concentration?",
    "seeds": [
      "Elevated circulating thymine concentration"
    ],
    "gold_answer": "Abnormal circulating pyrimidine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09403",
    "question": "What phenotype is associated with Orofaciodigital syndrome XIV?",
    "seeds": [
      "Orofaciodigital syndrome XIV"
    ],
    "gold_answer": "Holoprosencephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09404",
    "question": "What is associated with Cluster headache, familial?",
    "seeds": [
      "Cluster headache, familial"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09405",
    "question": "What is associated with Palmoplantar keratoderma, epidermolytic?",
    "seeds": [
      "Palmoplantar keratoderma, epidermolytic"
    ],
    "gold_answer": "Abnormal circulating IgE concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09406",
    "question": "What is associated with Enlarged metacarpal epiphyses?",
    "seeds": [
      "Enlarged metacarpal epiphyses"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09407",
    "question": "What is associated with Calcium phosphate nephrolithiasis?",
    "seeds": [
      "Calcium phosphate nephrolithiasis"
    ],
    "gold_answer": "Calcium nephrolithiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09408",
    "question": "What is associated with Premature pubarche?",
    "seeds": [
      "Premature pubarche"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09409",
    "question": "What is associated with Focal cortical dysplasia type Ic?",
    "seeds": [
      "Focal cortical dysplasia type Ic"
    ],
    "gold_answer": "Focal cortical dysplasia type Ib",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09410",
    "question": "What is associated with Abnormal total T cell count?",
    "seeds": [
      "Abnormal total T cell count"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09411",
    "question": "What is associated with Myopathy, lactic acidosis, and sideroblastic anemia 1?",
    "seeds": [
      "Myopathy, lactic acidosis, and sideroblastic anemia 1"
    ],
    "gold_answer": "Erythrocyte inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09412",
    "question": "What is associated with Partial duplication of the phalanx of hand?",
    "seeds": [
      "Partial duplication of the phalanx of hand"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09413",
    "question": "What is associated with Decreased stool elastase level?",
    "seeds": [
      "Decreased stool elastase level"
    ],
    "gold_answer": "Abnormal stool composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09414",
    "question": "What is associated with Podocytic mitochondrial proliferation?",
    "seeds": [
      "Podocytic mitochondrial proliferation"
    ],
    "gold_answer": "Abnormal glomerular visceral epithelial cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09415",
    "question": "What is associated with Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia?",
    "seeds": [
      "Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09416",
    "question": "What is associated with Reticular pattern on pulmonary HRCT?",
    "seeds": [
      "Reticular pattern on pulmonary HRCT"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09417",
    "question": "What is associated with Spinocerebellar ataxia type 17?",
    "seeds": [
      "Spinocerebellar ataxia type 17"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09418",
    "question": "What is associated with Fractured vertebra?",
    "seeds": [
      "Fractured vertebra"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09419",
    "question": "What is associated with Spastic paraplegia type 7?",
    "seeds": [
      "Spastic paraplegia type 7"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09420",
    "question": "What is associated with Impaired ocular abduction?",
    "seeds": [
      "Impaired ocular abduction"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09421",
    "question": "What is associated with Abnormality of the radioulnar joints?",
    "seeds": [
      "Abnormality of the radioulnar joints"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09422",
    "question": "What is associated with Diminished MSH6 expression?",
    "seeds": [
      "Diminished MSH6 expression"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09423",
    "question": "What is associated with Amelia involving the upper limbs?",
    "seeds": [
      "Amelia involving the upper limbs"
    ],
    "gold_answer": "Aplasia/hypoplasia of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09424",
    "question": "What is associated with Spastic paraplegia 42, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 42, autosomal dominant"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09425",
    "question": "What is associated with Uhl's anomaly?",
    "seeds": [
      "Uhl's anomaly"
    ],
    "gold_answer": "Congenital malformation of the right heart",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09426",
    "question": "What is associated with Growth abnormality?",
    "seeds": [
      "Growth abnormality"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09427",
    "question": "What is associated with Hereditary nonpolyposis colorectal carcinoma?",
    "seeds": [
      "Hereditary nonpolyposis colorectal carcinoma"
    ],
    "gold_answer": "Abnormal large intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09428",
    "question": "What is associated with Pancreatic squamous cell carcinoma?",
    "seeds": [
      "Pancreatic squamous cell carcinoma"
    ],
    "gold_answer": "Neoplasm of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09429",
    "question": "What phenotype is associated with Adult-onset cervical dystonia, DYT23 type?",
    "seeds": [
      "Adult-onset cervical dystonia, DYT23 type"
    ],
    "gold_answer": "Writer's cramp",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09430",
    "question": "What is associated with Bounding pulse?",
    "seeds": [
      "Bounding pulse"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09431",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 9A?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 9A"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09432",
    "question": "What is associated with Deafness, neurosensory, autosomal recessive 7?",
    "seeds": [
      "Deafness, neurosensory, autosomal recessive 7"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09433",
    "question": "What is associated with Abnormal distribution of CD56 bright/dim natural killer cells?",
    "seeds": [
      "Abnormal distribution of CD56 bright/dim natural killer cells"
    ],
    "gold_answer": "Abnormal natural killer subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09434",
    "question": "What phenotype is associated with Retinal dystrophy, iris coloboma, and comedogenic acne syndrome?",
    "seeds": [
      "Retinal dystrophy, iris coloboma, and comedogenic acne syndrome"
    ],
    "gold_answer": "Decreased circulating retinol-binding protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09435",
    "question": "What is associated with Central?",
    "seeds": [
      "Central"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09436",
    "question": "What is associated with Emery-Dreifuss muscular dystrophy 7, autosomal dominant?",
    "seeds": [
      "Emery-Dreifuss muscular dystrophy 7, autosomal dominant"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09437",
    "question": "What is associated with Focal dystonia?",
    "seeds": [
      "Focal dystonia"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09438",
    "question": "What is associated with Aspiration pneumonia?",
    "seeds": [
      "Aspiration pneumonia"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09439",
    "question": "What phenotype is associated with Rafiq syndrome?",
    "seeds": [
      "Rafiq syndrome"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09440",
    "question": "What is associated with Wolfram syndrome?",
    "seeds": [
      "Wolfram syndrome"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09441",
    "question": "What is associated with Fanconi anemia, complementation group J?",
    "seeds": [
      "Fanconi anemia, complementation group J"
    ],
    "gold_answer": "Chromosome breakage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09442",
    "question": "What is associated with Hallermann-Streiff syndrome?",
    "seeds": [
      "Hallermann-Streiff syndrome"
    ],
    "gold_answer": "Sleep-related breathing disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09443",
    "question": "What is associated with Progressive visual loss?",
    "seeds": [
      "Progressive visual loss"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09444",
    "question": "What is associated with Delayed eruption of primary teeth?",
    "seeds": [
      "Delayed eruption of primary teeth"
    ],
    "gold_answer": "Abnormality of primary teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09445",
    "question": "What is associated with Squamous Papilloma?",
    "seeds": [
      "Squamous Papilloma"
    ],
    "gold_answer": "Neoplasm of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09446",
    "question": "What is associated with Cone-shaped capital femoral epiphysis?",
    "seeds": [
      "Cone-shaped capital femoral epiphysis"
    ],
    "gold_answer": "Abnormal femoral epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09447",
    "question": "What is associated with Chronic noninfectious lymphadenopathy?",
    "seeds": [
      "Chronic noninfectious lymphadenopathy"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09448",
    "question": "What is associated with Genetic anticipation with paternal anticipation bias?",
    "seeds": [
      "Genetic anticipation with paternal anticipation bias"
    ],
    "gold_answer": "Genetic anticipation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09449",
    "question": "What is associated with Hypergranulosis?",
    "seeds": [
      "Hypergranulosis"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09450",
    "question": "What is associated with Doll-like facies?",
    "seeds": [
      "Doll-like facies"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09451",
    "question": "What phenotype is associated with Microphthalmia, syndromic 1?",
    "seeds": [
      "Microphthalmia, syndromic 1"
    ],
    "gold_answer": "Decreased numbers of nephrons",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09452",
    "question": "What phenotype is associated with Acute encephalopathy with biphasic seizures and late reduced diffusion?",
    "seeds": [
      "Acute encephalopathy with biphasic seizures and late reduced diffusion"
    ],
    "gold_answer": "Takotsubo cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09453",
    "question": "What is associated with Aplasia/Hypoplasia of the tibia?",
    "seeds": [
      "Aplasia/Hypoplasia of the tibia"
    ],
    "gold_answer": "Aplasia/hypoplasia of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09454",
    "question": "What is associated with Embryonal neoplasm?",
    "seeds": [
      "Embryonal neoplasm"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09455",
    "question": "What is associated with Abnormal fundus fluorescein angiography?",
    "seeds": [
      "Abnormal fundus fluorescein angiography"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09456",
    "question": "What is associated with Abnormal serum osmolality?",
    "seeds": [
      "Abnormal serum osmolality"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09457",
    "question": "What is associated with Developmental delay with variable intellectual impairment and behavioral abnormalities?",
    "seeds": [
      "Developmental delay with variable intellectual impairment and behavioral abnormalities"
    ],
    "gold_answer": "Abnormality of upper lip vermillion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09458",
    "question": "What is associated with Abnormal CSF glycine concentration?",
    "seeds": [
      "Abnormal CSF glycine concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09459",
    "question": "What phenotype is associated with Ataxia-telangiectasia-like disorder 2?",
    "seeds": [
      "Ataxia-telangiectasia-like disorder 2"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09460",
    "question": "What is associated with Erythrokeratoderma ''en cocardes''?",
    "seeds": [
      "Erythrokeratoderma ''en cocardes''"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09461",
    "question": "What is associated with 46,XY difference of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency?",
    "seeds": [
      "46,XY difference of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency"
    ],
    "gold_answer": "External genital hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09462",
    "question": "What phenotype is associated with Night blindness, congenital stationary, type 1I?",
    "seeds": [
      "Night blindness, congenital stationary, type 1I"
    ],
    "gold_answer": "Tritanomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09463",
    "question": "What is associated with Repeated focal motor seizures?",
    "seeds": [
      "Repeated focal motor seizures"
    ],
    "gold_answer": "Status epilepticus with prominent motor symptoms",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09464",
    "question": "What is associated with Lytic defects of humeral diaphysis?",
    "seeds": [
      "Lytic defects of humeral diaphysis"
    ],
    "gold_answer": "Abnormal humeral diaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09465",
    "question": "What is associated with Developmental retinal vascular malformation?",
    "seeds": [
      "Developmental retinal vascular malformation"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09466",
    "question": "What is associated with Abnormal Th17 T cell proportion?",
    "seeds": [
      "Abnormal Th17 T cell proportion"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09467",
    "question": "What is associated with Argininosuccinic aciduria?",
    "seeds": [
      "Argininosuccinic aciduria"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09468",
    "question": "What is associated with Abnormal vasa vasorum morphology?",
    "seeds": [
      "Abnormal vasa vasorum morphology"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09469",
    "question": "What is associated with Delusional atmosphere?",
    "seeds": [
      "Delusional atmosphere"
    ],
    "gold_answer": "Delusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09470",
    "question": "What phenotype is associated with Activated PI3K-delta syndrome 1?",
    "seeds": [
      "Activated PI3K-delta syndrome 1"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09471",
    "question": "What is associated with History of gastric bypass surgery?",
    "seeds": [
      "History of gastric bypass surgery"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09472",
    "question": "What phenotype is associated with ALG8-CDG?",
    "seeds": [
      "ALG8-CDG"
    ],
    "gold_answer": "Abnormality of subcutaneous fat tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09473",
    "question": "What is associated with Reduced tissue galactocerebrosidase activity?",
    "seeds": [
      "Reduced tissue galactocerebrosidase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09474",
    "question": "What is associated with Pituitary dwarfism?",
    "seeds": [
      "Pituitary dwarfism"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09475",
    "question": "What is associated with Dyskeratosis, hereditary benign intraepithelial?",
    "seeds": [
      "Dyskeratosis, hereditary benign intraepithelial"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09476",
    "question": "What is associated with Periventricular laminar heterotopia?",
    "seeds": [
      "Periventricular laminar heterotopia"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09477",
    "question": "What is associated with CODAS syndrome?",
    "seeds": [
      "CODAS syndrome"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09478",
    "question": "What is associated with Reduced granulocyte CD59 level?",
    "seeds": [
      "Reduced granulocyte CD59 level"
    ],
    "gold_answer": "Reduced granulocyte surface marker level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09479",
    "question": "What is associated with Decreased 3-hydroxyisobutyrate dehydrogenase activity?",
    "seeds": [
      "Decreased 3-hydroxyisobutyrate dehydrogenase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09480",
    "question": "What is associated with Chondroitin-6-Sulfaturia, defective cellular immunity, nephrotic syndrome?",
    "seeds": [
      "Chondroitin-6-Sulfaturia, defective cellular immunity, nephrotic syndrome"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09481",
    "question": "What is associated with Spinocerebellar ataxia type 41?",
    "seeds": [
      "Spinocerebellar ataxia type 41"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09482",
    "question": "What is associated with Dermoodontodysplasia?",
    "seeds": [
      "Dermoodontodysplasia"
    ],
    "gold_answer": "Abnormality of the chin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09483",
    "question": "What phenotype is associated with Globulin anomaly involving beta (2a)-globulin?",
    "seeds": [
      "Globulin anomaly involving beta (2a)-globulin"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09484",
    "question": "What is associated with Eosinophil nuclear hypersegmentation?",
    "seeds": [
      "Eosinophil nuclear hypersegmentation"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09485",
    "question": "What phenotype is associated with Congenital disorder of deglycosylation 1?",
    "seeds": [
      "Congenital disorder of deglycosylation 1"
    ],
    "gold_answer": "Brachycephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09486",
    "question": "What is associated with Contracture of the proximal interphalangeal joint of the 3rd toe?",
    "seeds": [
      "Contracture of the proximal interphalangeal joint of the 3rd toe"
    ],
    "gold_answer": "Foot joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09487",
    "question": "What phenotype is associated with Immunodeficiency, common variable, 12?",
    "seeds": [
      "Immunodeficiency, common variable, 12"
    ],
    "gold_answer": "Inflammation of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09488",
    "question": "What is associated with Spondyloperipheral dysplasia-short ulna syndrome?",
    "seeds": [
      "Spondyloperipheral dysplasia-short ulna syndrome"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09489",
    "question": "What is associated with Tachyphagia?",
    "seeds": [
      "Tachyphagia"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09490",
    "question": "What phenotype is associated with Sulfhemoglobinemia, congenital?",
    "seeds": [
      "Sulfhemoglobinemia, congenital"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09491",
    "question": "What is associated with Spasticity, childhood-onset, with hyperglycinemia?",
    "seeds": [
      "Spasticity, childhood-onset, with hyperglycinemia"
    ],
    "gold_answer": "Abnormal spinal cord physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09492",
    "question": "What is associated with Abnormality of the radial head?",
    "seeds": [
      "Abnormality of the radial head"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09493",
    "question": "What is associated with Empty sella turcica?",
    "seeds": [
      "Empty sella turcica"
    ],
    "gold_answer": "Abnormal sella turcica morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09494",
    "question": "What is associated with Weakness of the intrinsic hand muscles?",
    "seeds": [
      "Weakness of the intrinsic hand muscles"
    ],
    "gold_answer": "Abnormality of the musculature of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09495",
    "question": "What is associated with Limitation of knee mobility?",
    "seeds": [
      "Limitation of knee mobility"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09496",
    "question": "What is associated with PR segment elevation?",
    "seeds": [
      "PR segment elevation"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09497",
    "question": "What phenotype is associated with Optic atrophy--spastic paraplegia syndrome?",
    "seeds": [
      "Optic atrophy--spastic paraplegia syndrome"
    ],
    "gold_answer": "Abnormal oral glucose tolerance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09498",
    "question": "What is associated with Abnormality of somatosensory evoked potentials?",
    "seeds": [
      "Abnormality of somatosensory evoked potentials"
    ],
    "gold_answer": "Abnormality of peripheral nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09499",
    "question": "What is associated with Abnormal uvea morphology?",
    "seeds": [
      "Abnormal uvea morphology"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09500",
    "question": "What is associated with X-linked inheritance?",
    "seeds": [
      "X-linked inheritance"
    ],
    "gold_answer": "Mendelian inheritance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09501",
    "question": "What phenotype is associated with Muscle glycogenosis, X-linked?",
    "seeds": [
      "Muscle glycogenosis, X-linked"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09502",
    "question": "What is associated with Elevated circulating biliverdin concentration?",
    "seeds": [
      "Elevated circulating biliverdin concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09503",
    "question": "What phenotype is associated with Cochleosaccular degeneration-cataract syndrome?",
    "seeds": [
      "Cochleosaccular degeneration-cataract syndrome"
    ],
    "gold_answer": "Progressive sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09504",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Patchy sclerosis of proximal toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09505",
    "question": "What is associated with Multifocal neonatal sequential seizure?",
    "seeds": [
      "Multifocal neonatal sequential seizure"
    ],
    "gold_answer": "Neonatal electro-clinical sequential seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09506",
    "question": "What is associated with Myxoma, intracardiac?",
    "seeds": [
      "Myxoma, intracardiac"
    ],
    "gold_answer": "Abnormal heart valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09507",
    "question": "What is associated with Corneal guttata?",
    "seeds": [
      "Corneal guttata"
    ],
    "gold_answer": "Abnormal Descemet membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09508",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type IQ?",
    "seeds": [
      "Congenital disorder of glycosylation, type IQ"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09509",
    "question": "What is associated with Generalized non-motor (absence) seizure?",
    "seeds": [
      "Generalized non-motor (absence) seizure"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09510",
    "question": "What is associated with Decreased circulating hydroxyproline concentration?",
    "seeds": [
      "Decreased circulating hydroxyproline concentration"
    ],
    "gold_answer": "Abnormal circulating glutamine family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09511",
    "question": "What is associated with Atherosclerosis?",
    "seeds": [
      "Atherosclerosis"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09512",
    "question": "What is associated with Alpha-methylacetoacetic aciduria?",
    "seeds": [
      "Alpha-methylacetoacetic aciduria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09513",
    "question": "What is associated with Isolated humero-radial synostosis?",
    "seeds": [
      "Isolated humero-radial synostosis"
    ],
    "gold_answer": "Coloboma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09514",
    "question": "What is associated with Increased effector memory CD8+ T cell proportion?",
    "seeds": [
      "Increased effector memory CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal CD8+ T cell subset proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09515",
    "question": "What is associated with Abnormal circulating IgD concentration?",
    "seeds": [
      "Abnormal circulating IgD concentration"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09516",
    "question": "What is associated with Alkaline urine?",
    "seeds": [
      "Alkaline urine"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09517",
    "question": "What is associated with Thickened ribs?",
    "seeds": [
      "Thickened ribs"
    ],
    "gold_answer": "Abnormal rib morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09518",
    "question": "What is associated with Third ray metacarpophalangeal synostosis?",
    "seeds": [
      "Third ray metacarpophalangeal synostosis"
    ],
    "gold_answer": "Metacarpal synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09519",
    "question": "What phenotype is associated with Pontocerebellar hypoplasia, type 2D?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 2D"
    ],
    "gold_answer": "Irritability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09520",
    "question": "What phenotype is associated with Myasthenic syndrome, congenital, 4B, fast-channel?",
    "seeds": [
      "Myasthenic syndrome, congenital, 4B, fast-channel"
    ],
    "gold_answer": "Ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09521",
    "question": "What phenotype is associated with Nemaline myopathy 8?",
    "seeds": [
      "Nemaline myopathy 8"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09522",
    "question": "What is associated with Paravertebral mass?",
    "seeds": [
      "Paravertebral mass"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09523",
    "question": "What is associated with Pituitary hormone deficiency, combined or isolated, 7?",
    "seeds": [
      "Pituitary hormone deficiency, combined or isolated, 7"
    ],
    "gold_answer": "Obesity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09524",
    "question": "What is associated with Reduced MHC II cell surface expression?",
    "seeds": [
      "Reduced MHC II cell surface expression"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09525",
    "question": "What is associated with Pulmonary carcinoid tumor?",
    "seeds": [
      "Pulmonary carcinoid tumor"
    ],
    "gold_answer": "Neuroendocrine neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09526",
    "question": "What phenotype is associated with Vesicoureteral reflux 8?",
    "seeds": [
      "Vesicoureteral reflux 8"
    ],
    "gold_answer": "Joint hypermobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09527",
    "question": "What is associated with Bleeding disorder, platelet-type, 24, autosomal dominant?",
    "seeds": [
      "Bleeding disorder, platelet-type, 24, autosomal dominant"
    ],
    "gold_answer": "Abnormal platelet count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09528",
    "question": "What is associated with Focal aware emotional seizure with anger?",
    "seeds": [
      "Focal aware emotional seizure with anger"
    ],
    "gold_answer": "Focal aware emotional seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09529",
    "question": "What is associated with Methioninuria?",
    "seeds": [
      "Methioninuria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09530",
    "question": "What phenotype is associated with Hypercalciuria, absorptive, susceptibility to?",
    "seeds": [
      "Hypercalciuria, absorptive, susceptibility to"
    ],
    "gold_answer": "Calcium oxalate nephrolithiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09531",
    "question": "What is associated with Clinodactyly of the 5th finger?",
    "seeds": [
      "Clinodactyly of the 5th finger"
    ],
    "gold_answer": "Deviation of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09532",
    "question": "What is associated with Retinal vasculitis?",
    "seeds": [
      "Retinal vasculitis"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09533",
    "question": "What is associated with Electronic cigarette exposure history?",
    "seeds": [
      "Electronic cigarette exposure history"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09534",
    "question": "What is associated with Multiple bilateral pneumothoraces?",
    "seeds": [
      "Multiple bilateral pneumothoraces"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09535",
    "question": "What is associated with Abnormality of lateral rectus extra-ocular muscle?",
    "seeds": [
      "Abnormality of lateral rectus extra-ocular muscle"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09536",
    "question": "What phenotype is associated with Neurodevelopmental disorder with microcephaly and gray sclerae?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly and gray sclerae"
    ],
    "gold_answer": "Lower limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09537",
    "question": "What is associated with Fractured talus?",
    "seeds": [
      "Fractured talus"
    ],
    "gold_answer": "Fractured tarsal bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09538",
    "question": "What is associated with Joint contracture of the 5th finger?",
    "seeds": [
      "Joint contracture of the 5th finger"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09539",
    "question": "What is associated with Exocrine pancreatic insufficiency?",
    "seeds": [
      "Exocrine pancreatic insufficiency"
    ],
    "gold_answer": "Abnormality of exocrine pancreas physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09540",
    "question": "What is associated with Abnormal urinary pyrimidine level?",
    "seeds": [
      "Abnormal urinary pyrimidine level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09541",
    "question": "What is associated with Increased CD4+ memory T cell proportion?",
    "seeds": [
      "Increased CD4+ memory T cell proportion"
    ],
    "gold_answer": "Abnormal memory T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09542",
    "question": "What is associated with Congenital posterior occipital alopecia?",
    "seeds": [
      "Congenital posterior occipital alopecia"
    ],
    "gold_answer": "Congenital abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09543",
    "question": "What phenotype is associated with Bent bone dysplasia syndrome?",
    "seeds": [
      "Bent bone dysplasia syndrome"
    ],
    "gold_answer": "Bell-shaped thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09544",
    "question": "What is associated with Femoral osteopoikilosis?",
    "seeds": [
      "Femoral osteopoikilosis"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09545",
    "question": "What is associated with Malformation of mandibular premolar?",
    "seeds": [
      "Malformation of mandibular premolar"
    ],
    "gold_answer": "Abnormal dental morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09546",
    "question": "What phenotype is associated with Periventricular nodular heterotopia 9?",
    "seeds": [
      "Periventricular nodular heterotopia 9"
    ],
    "gold_answer": "Anotia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09547",
    "question": "What is associated with Hyperkalemia?",
    "seeds": [
      "Hyperkalemia"
    ],
    "gold_answer": "Abnormal blood monovalent inorganic cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09548",
    "question": "What is associated with Fractured scapula?",
    "seeds": [
      "Fractured scapula"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09549",
    "question": "What is associated with Broad distal phalanx of the 2nd toe?",
    "seeds": [
      "Broad distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Broad phalanx of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09550",
    "question": "What is associated with Myotonia of the jaw?",
    "seeds": [
      "Myotonia of the jaw"
    ],
    "gold_answer": "Myotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09551",
    "question": "What is associated with Medial calcification of medium-sized arteries?",
    "seeds": [
      "Medial calcification of medium-sized arteries"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09552",
    "question": "What is associated with Neoplasm of the central nervous system?",
    "seeds": [
      "Neoplasm of the central nervous system"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09553",
    "question": "What is associated with Noonan syndrome 5?",
    "seeds": [
      "Noonan syndrome 5"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09554",
    "question": "What is associated with Vasculitis by anatomical site?",
    "seeds": [
      "Vasculitis by anatomical site"
    ],
    "gold_answer": "Vasculitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09555",
    "question": "What is associated with Partial duplication of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Partial duplication of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Duplication of phalanx of 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09556",
    "question": "What is associated with Triceps aplasia?",
    "seeds": [
      "Triceps aplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the triceps",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09557",
    "question": "What is associated with Parastremmatic dwarfism?",
    "seeds": [
      "Parastremmatic dwarfism"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09558",
    "question": "What phenotype is associated with Spinal muscular atrophy, Jokela type?",
    "seeds": [
      "Spinal muscular atrophy, Jokela type"
    ],
    "gold_answer": "Elevated circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09559",
    "question": "What is associated with Cross-fusion of the forearm bones?",
    "seeds": [
      "Cross-fusion of the forearm bones"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09560",
    "question": "What is associated with Osteolytic defects of the phalanges of the 5th toe?",
    "seeds": [
      "Osteolytic defects of the phalanges of the 5th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09561",
    "question": "What phenotype is associated with Premature ovarian failure 14?",
    "seeds": [
      "Premature ovarian failure 14"
    ],
    "gold_answer": "Primary amenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09562",
    "question": "What is associated with Penoscrotal hypospadias?",
    "seeds": [
      "Penoscrotal hypospadias"
    ],
    "gold_answer": "Hypospadias",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09563",
    "question": "What phenotype is associated with Arthrogryposis, distal, type 12?",
    "seeds": [
      "Arthrogryposis, distal, type 12"
    ],
    "gold_answer": "Agenesis of maxillary incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09564",
    "question": "What is associated with Anti-glomerular basement membrane-antibody positivity?",
    "seeds": [
      "Anti-glomerular basement membrane-antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09565",
    "question": "What is associated with Elevated residual volume?",
    "seeds": [
      "Elevated residual volume"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09566",
    "question": "What is associated with Frontal polymicrogyria?",
    "seeds": [
      "Frontal polymicrogyria"
    ],
    "gold_answer": "Abnormal cerebral cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09567",
    "question": "What is associated with Absence of the pulmonary valve?",
    "seeds": [
      "Absence of the pulmonary valve"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09568",
    "question": "What is associated with Choroid hemorrhage?",
    "seeds": [
      "Choroid hemorrhage"
    ],
    "gold_answer": "Hemorrhage of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09569",
    "question": "What phenotype is associated with X-LINKED intellectual disability, Abidi type?",
    "seeds": [
      "X-LINKED intellectual disability, Abidi type"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09570",
    "question": "What phenotype is associated with Mitochondrial complex I deficiency, nuclear type 5?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 5"
    ],
    "gold_answer": "Developmental regression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09571",
    "question": "What phenotype is associated with Glycogen storage disease, type IXa1?",
    "seeds": [
      "Glycogen storage disease, type IXa1"
    ],
    "gold_answer": "Elevated circulating hepatic transaminase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09572",
    "question": "What is associated with Jung syndrome?",
    "seeds": [
      "Jung syndrome"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09573",
    "question": "What is associated with Delayed cranial suture closure?",
    "seeds": [
      "Delayed cranial suture closure"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09574",
    "question": "What is associated with Charcot-Marie-Tooth disease, recessive intermediate C?",
    "seeds": [
      "Charcot-Marie-Tooth disease, recessive intermediate C"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09575",
    "question": "What is associated with Glucocorticoid deficiency 1?",
    "seeds": [
      "Glucocorticoid deficiency 1"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09576",
    "question": "What phenotype is associated with Tuberous sclerosis-2?",
    "seeds": [
      "Tuberous sclerosis-2"
    ],
    "gold_answer": "Subungual fibromas",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09577",
    "question": "What is associated with Sclerosis of 2nd toe phalanx?",
    "seeds": [
      "Sclerosis of 2nd toe phalanx"
    ],
    "gold_answer": "Sclerosis of foot bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09578",
    "question": "What is associated with Lithoptysis?",
    "seeds": [
      "Lithoptysis"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09579",
    "question": "What is associated with Glossitis?",
    "seeds": [
      "Glossitis"
    ],
    "gold_answer": "Abnormal tongue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09580",
    "question": "What is associated with Pontocerebellar hypoplasia, type 5?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 5"
    ],
    "gold_answer": "Hypoplasia of the pons",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09581",
    "question": "What is associated with Psychomotor deterioration?",
    "seeds": [
      "Psychomotor deterioration"
    ],
    "gold_answer": "Cognitive impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09582",
    "question": "What is associated with Lactase deficiency, congenital?",
    "seeds": [
      "Lactase deficiency, congenital"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09583",
    "question": "What is associated with Sclerotic foci of the humerus?",
    "seeds": [
      "Sclerotic foci of the humerus"
    ],
    "gold_answer": "Humeral sclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09584",
    "question": "What is associated with ANK3-related intellectual disability-sleep disturbance syndrome?",
    "seeds": [
      "ANK3-related intellectual disability-sleep disturbance syndrome"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09585",
    "question": "What is associated with Scimitar anomaly?",
    "seeds": [
      "Scimitar anomaly"
    ],
    "gold_answer": "Anomalous pulmonary venous return",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09586",
    "question": "What is associated with Abnormal cardiac output?",
    "seeds": [
      "Abnormal cardiac output"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09587",
    "question": "What is associated with Abnormal 5th metacarpal morphology?",
    "seeds": [
      "Abnormal 5th metacarpal morphology"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09588",
    "question": "What phenotype is associated with Spermatogenic failure 91?",
    "seeds": [
      "Spermatogenic failure 91"
    ],
    "gold_answer": "Oligozoospermia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09589",
    "question": "What is associated with Ovarian sex cord-stromal tumor?",
    "seeds": [
      "Ovarian sex cord-stromal tumor"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09590",
    "question": "What is associated with Abnormal fecal osmolality?",
    "seeds": [
      "Abnormal fecal osmolality"
    ],
    "gold_answer": "Abnormal stool composition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09591",
    "question": "What is associated with Paget disease of bone 2, early-onset?",
    "seeds": [
      "Paget disease of bone 2, early-onset"
    ],
    "gold_answer": "Abnormal brainstem morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09592",
    "question": "What is associated with Edema of the dorsum of feet?",
    "seeds": [
      "Edema of the dorsum of feet"
    ],
    "gold_answer": "Pedal edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09593",
    "question": "What is associated with Lessel-Kreienkamp syndrome?",
    "seeds": [
      "Lessel-Kreienkamp syndrome"
    ],
    "gold_answer": "Short attention span",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09594",
    "question": "What is associated with Metacarpal pseudoepiphysis?",
    "seeds": [
      "Metacarpal pseudoepiphysis"
    ],
    "gold_answer": "Pseudoepiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09595",
    "question": "What is associated with Nephrotic syndrome, type 26?",
    "seeds": [
      "Nephrotic syndrome, type 26"
    ],
    "gold_answer": "Glomerular sclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09596",
    "question": "What is associated with Sternocleidomastoid amyotrophy?",
    "seeds": [
      "Sternocleidomastoid amyotrophy"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09597",
    "question": "What is associated with Radial deviation of finger?",
    "seeds": [
      "Radial deviation of finger"
    ],
    "gold_answer": "Radial deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09598",
    "question": "What is associated with Uterine adenofibroma?",
    "seeds": [
      "Uterine adenofibroma"
    ],
    "gold_answer": "Abnormal uterus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09599",
    "question": "What is associated with X-linked progressive cerebellar ataxia?",
    "seeds": [
      "X-linked progressive cerebellar ataxia"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09600",
    "question": "What is associated with Secondary amenorrhea?",
    "seeds": [
      "Secondary amenorrhea"
    ],
    "gold_answer": "Amenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09601",
    "question": "What is associated with Reduced circulating reticulated platelet count?",
    "seeds": [
      "Reduced circulating reticulated platelet count"
    ],
    "gold_answer": "Abnormality of thrombocytes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09602",
    "question": "What is associated with Recessive mitochondrial ataxia syndrome?",
    "seeds": [
      "Recessive mitochondrial ataxia syndrome"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09603",
    "question": "What is associated with Long face?",
    "seeds": [
      "Long face"
    ],
    "gold_answer": "Large face",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09604",
    "question": "What is associated with Abnormal intervertebral disk morphology?",
    "seeds": [
      "Abnormal intervertebral disk morphology"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09605",
    "question": "What is associated with Asymmetry of the nares?",
    "seeds": [
      "Asymmetry of the nares"
    ],
    "gold_answer": "Abnormal nostril morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09606",
    "question": "What is associated with Elevated circulating tiglylcarnitine concentration?",
    "seeds": [
      "Elevated circulating tiglylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating C5 acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09607",
    "question": "What is associated with Von Willebrand disease type 2A?",
    "seeds": [
      "Von Willebrand disease type 2A"
    ],
    "gold_answer": "VWF",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09608",
    "question": "What is associated with Fetal neck mass?",
    "seeds": [
      "Fetal neck mass"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09609",
    "question": "What is associated with Synostosis involving bones of the feet?",
    "seeds": [
      "Synostosis involving bones of the feet"
    ],
    "gold_answer": "Synostosis involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09610",
    "question": "What is associated with Congenital brain dysgenesis due to glutamine synthetase deficiency?",
    "seeds": [
      "Congenital brain dysgenesis due to glutamine synthetase deficiency"
    ],
    "gold_answer": "GLUL",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_09611",
    "question": "What is associated with Fingerpad telangiectases?",
    "seeds": [
      "Fingerpad telangiectases"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09612",
    "question": "What is associated with Spina bifida occulta at S1?",
    "seeds": [
      "Spina bifida occulta at S1"
    ],
    "gold_answer": "Spina bifida",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09613",
    "question": "What is associated with 1-5 toe syndactyly?",
    "seeds": [
      "1-5 toe syndactyly"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09614",
    "question": "What is associated with Liberfarb syndrome?",
    "seeds": [
      "Liberfarb syndrome"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09615",
    "question": "What is associated with Limited foot inversion?",
    "seeds": [
      "Limited foot inversion"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09616",
    "question": "What is associated with PULMONARY ARTERIOVENOUS FISTULAS?",
    "seeds": [
      "PULMONARY ARTERIOVENOUS FISTULAS"
    ],
    "gold_answer": "Abnormal fingertip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09617",
    "question": "What is associated with Xeroderma pigmentosum, group C?",
    "seeds": [
      "Xeroderma pigmentosum, group C"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09618",
    "question": "What is associated with Autosomal recessive myogenic arthrogryposis multiplex congenita?",
    "seeds": [
      "Autosomal recessive myogenic arthrogryposis multiplex congenita"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09619",
    "question": "What is associated with Epidermolytic hyperkeratosis 2?",
    "seeds": [
      "Epidermolytic hyperkeratosis 2"
    ],
    "gold_answer": "Palmar hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09620",
    "question": "What is associated with Complete duplication of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Complete duplication of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Complete duplication of the proximal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09621",
    "question": "What is associated with Embryonal renal neoplasm?",
    "seeds": [
      "Embryonal renal neoplasm"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09622",
    "question": "What is associated with Spondylometaphyseal dysplasia-cone-rod dystrophy syndrome?",
    "seeds": [
      "Spondylometaphyseal dysplasia-cone-rod dystrophy syndrome"
    ],
    "gold_answer": "Abnormal femoral neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09623",
    "question": "What is associated with Buphthalmos?",
    "seeds": [
      "Buphthalmos"
    ],
    "gold_answer": "Developmental glaucoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09624",
    "question": "What phenotype is associated with Cardiomyopathy, dilated, 1M?",
    "seeds": [
      "Cardiomyopathy, dilated, 1M"
    ],
    "gold_answer": "Impaired myocardial contractility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09625",
    "question": "What is associated with Adult-onset night blindness?",
    "seeds": [
      "Adult-onset night blindness"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09626",
    "question": "What is associated with Familial steroid-resistant nephrotic syndrome with sensorineural deafness?",
    "seeds": [
      "Familial steroid-resistant nephrotic syndrome with sensorineural deafness"
    ],
    "gold_answer": "COQ6",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09627",
    "question": "What is associated with Hypergonadotropic hypogonadism?",
    "seeds": [
      "Hypergonadotropic hypogonadism"
    ],
    "gold_answer": "Hypogonadism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09628",
    "question": "What is associated with Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 6?",
    "seeds": [
      "Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 6"
    ],
    "gold_answer": "Erosion of oral mucosa",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09629",
    "question": "What is associated with Increased CSF lactate?",
    "seeds": [
      "Increased CSF lactate"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09630",
    "question": "What is associated with Anemia due to reduced life span of red cells?",
    "seeds": [
      "Anemia due to reduced life span of red cells"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09631",
    "question": "What is associated with Abnormal large intestinal mucosa morphology?",
    "seeds": [
      "Abnormal large intestinal mucosa morphology"
    ],
    "gold_answer": "Abnormal large intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09632",
    "question": "What is associated with Anti-microfilaria antibody positivity?",
    "seeds": [
      "Anti-microfilaria antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09633",
    "question": "What is associated with Chromhidrosis?",
    "seeds": [
      "Chromhidrosis"
    ],
    "gold_answer": "Abnormal sweat gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09634",
    "question": "What is associated with Abnormal thorax morphology?",
    "seeds": [
      "Abnormal thorax morphology"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09635",
    "question": "What is associated with Recurrent otitis media?",
    "seeds": [
      "Recurrent otitis media"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09636",
    "question": "What is associated with Macule?",
    "seeds": [
      "Macule"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09637",
    "question": "What is associated with Pear-shaped nose?",
    "seeds": [
      "Pear-shaped nose"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09638",
    "question": "What phenotype is associated with Hypoparathyroidism, X-linked?",
    "seeds": [
      "Hypoparathyroidism, X-linked"
    ],
    "gold_answer": "Congenital hypoparathyroidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09639",
    "question": "What is associated with Bone marrow failure syndrome 5?",
    "seeds": [
      "Bone marrow failure syndrome 5"
    ],
    "gold_answer": "Abnormal chromosome morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09640",
    "question": "What is associated with Autosomal recessive methemoglobinemia?",
    "seeds": [
      "Autosomal recessive methemoglobinemia"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09641",
    "question": "What phenotype is associated with Bamforth-Lazarus syndrome?",
    "seeds": [
      "Bamforth-Lazarus syndrome"
    ],
    "gold_answer": "Bilateral choanal atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09642",
    "question": "What is associated with Aplasia of the 5th finger?",
    "seeds": [
      "Aplasia of the 5th finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09643",
    "question": "What is associated with Hypotrophy of the small hand muscles?",
    "seeds": [
      "Hypotrophy of the small hand muscles"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09644",
    "question": "What is associated with Salmonella osteomyelitis?",
    "seeds": [
      "Salmonella osteomyelitis"
    ],
    "gold_answer": "Osteomyelitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09645",
    "question": "What is associated with Growth hormone deficiency, isolated partial?",
    "seeds": [
      "Growth hormone deficiency, isolated partial"
    ],
    "gold_answer": "Anterior hypopituitarism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09646",
    "question": "What is associated with Aplasia/Hypoplasia of the colon?",
    "seeds": [
      "Aplasia/Hypoplasia of the colon"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09647",
    "question": "What is associated with Anti-thyroid-stimulating hormone receptor antibody positivity?",
    "seeds": [
      "Anti-thyroid-stimulating hormone receptor antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09648",
    "question": "What is associated with Increased circulating interleukin 21 concentration?",
    "seeds": [
      "Increased circulating interleukin 21 concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09649",
    "question": "What is associated with Episodic muscle weakness, X-linked?",
    "seeds": [
      "Episodic muscle weakness, X-linked"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09650",
    "question": "What is associated with Choroidal melanoma?",
    "seeds": [
      "Choroidal melanoma"
    ],
    "gold_answer": "Abnormal ciliary body morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09651",
    "question": "What phenotype is associated with MALT lymphoma?",
    "seeds": [
      "MALT lymphoma"
    ],
    "gold_answer": "Nausea and vomiting",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09652",
    "question": "What is associated with Parkinson disease 7, autosomal recessive early-onset?",
    "seeds": [
      "Parkinson disease 7, autosomal recessive early-onset"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09653",
    "question": "What is associated with Brachymorphism-onychodysplasia-dysphalangism syndrome?",
    "seeds": [
      "Brachymorphism-onychodysplasia-dysphalangism syndrome"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09654",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 29?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 29"
    ],
    "gold_answer": "Periorbital fullness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09655",
    "question": "What is associated with Leber congenital amaurosis 14?",
    "seeds": [
      "Leber congenital amaurosis 14"
    ],
    "gold_answer": "Abnormal electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09656",
    "question": "What is associated with Intellectual developmental disorder, X-linked 99, syndromic, female-restricted?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 99, syndromic, female-restricted"
    ],
    "gold_answer": "Cleft soft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09657",
    "question": "What is associated with Mandibulofacial dysostosis-microcephaly syndrome?",
    "seeds": [
      "Mandibulofacial dysostosis-microcephaly syndrome"
    ],
    "gold_answer": "Abnormal maxilla morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09658",
    "question": "What is associated with Abnormal muscle fiber alpha sarcoglycan?",
    "seeds": [
      "Abnormal muscle fiber alpha sarcoglycan"
    ],
    "gold_answer": "Abnormal muscle fiber protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09659",
    "question": "What is associated with Aplasia of the eccrine sweat glands?",
    "seeds": [
      "Aplasia of the eccrine sweat glands"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the sweat glands",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09660",
    "question": "What is associated with Clinodactyly of the thumb?",
    "seeds": [
      "Clinodactyly of the thumb"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09661",
    "question": "What phenotype is associated with Deafness, autosomal dominant 25?",
    "seeds": [
      "Deafness, autosomal dominant 25"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09662",
    "question": "What is associated with Renal arteriolar lumen cholesterol emboli?",
    "seeds": [
      "Renal arteriolar lumen cholesterol emboli"
    ],
    "gold_answer": "Abnormal renal arteriole lumen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09663",
    "question": "What is associated with Nevus flammeus of nape of neck?",
    "seeds": [
      "Nevus flammeus of nape of neck"
    ],
    "gold_answer": "Nevus flammeus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09664",
    "question": "What is associated with Gallbladder dysfunction?",
    "seeds": [
      "Gallbladder dysfunction"
    ],
    "gold_answer": "Abnormal gallbladder physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09665",
    "question": "What is associated with Anxiety?",
    "seeds": [
      "Anxiety"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09666",
    "question": "What is associated with Focal impaired awareness emotional seizure?",
    "seeds": [
      "Focal impaired awareness emotional seizure"
    ],
    "gold_answer": "Focal impaired awareness seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09667",
    "question": "What is associated with Rhinitis?",
    "seeds": [
      "Rhinitis"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09668",
    "question": "What is associated with Decreased transferrin saturation?",
    "seeds": [
      "Decreased transferrin saturation"
    ],
    "gold_answer": "Abnormal blood transition element cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09669",
    "question": "What is associated with Abnormal plasma cell count?",
    "seeds": [
      "Abnormal plasma cell count"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09670",
    "question": "What is associated with Flattened epiphysis?",
    "seeds": [
      "Flattened epiphysis"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09671",
    "question": "What is associated with Facial wrinkling?",
    "seeds": [
      "Facial wrinkling"
    ],
    "gold_answer": "Premature skin wrinkling",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09672",
    "question": "What is associated with Congenital hypertrophy of left ventricle?",
    "seeds": [
      "Congenital hypertrophy of left ventricle"
    ],
    "gold_answer": "Left ventricular hypertrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09673",
    "question": "What is associated with Mesangial matrix expansion?",
    "seeds": [
      "Mesangial matrix expansion"
    ],
    "gold_answer": "Abnormal glomerular mesangium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09674",
    "question": "What is associated with Cutaneous mastocytosis-deafness-microtia syndrome?",
    "seeds": [
      "Cutaneous mastocytosis-deafness-microtia syndrome"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09675",
    "question": "What is associated with Elevated circulating carcinoma antigen 125 concentration?",
    "seeds": [
      "Elevated circulating carcinoma antigen 125 concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09676",
    "question": "What is associated with Paracentral scotoma?",
    "seeds": [
      "Paracentral scotoma"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09677",
    "question": "What is associated with Nodular-perilymphatic pattern on pulmonary HRCT?",
    "seeds": [
      "Nodular-perilymphatic pattern on pulmonary HRCT"
    ],
    "gold_answer": "Pulmonary interstitial high-resolution computed tomography abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09678",
    "question": "What is associated with Ehlers-Danlos syndrome, classic-like, 2?",
    "seeds": [
      "Ehlers-Danlos syndrome, classic-like, 2"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the eyebrow",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09679",
    "question": "What phenotype is associated with Dystonia 28, childhood-onset?",
    "seeds": [
      "Dystonia 28, childhood-onset"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09680",
    "question": "What is associated with Increased size of the mandible?",
    "seeds": [
      "Increased size of the mandible"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09681",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 1?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 1"
    ],
    "gold_answer": "Abnormal hepatobiliary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09682",
    "question": "What is associated with Macrocephaly-developmental delay syndrome?",
    "seeds": [
      "Macrocephaly-developmental delay syndrome"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09683",
    "question": "What is associated with Intellectual disability syndrome due to a DYRK1A point mutation?",
    "seeds": [
      "Intellectual disability syndrome due to a DYRK1A point mutation"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09684",
    "question": "What is associated with Peroneal nerve, accessory deep?",
    "seeds": [
      "Peroneal nerve, accessory deep"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09685",
    "question": "What is associated with Primary condylar hyperplasia?",
    "seeds": [
      "Primary condylar hyperplasia"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09686",
    "question": "What is associated with Hypoargininemia?",
    "seeds": [
      "Hypoargininemia"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09687",
    "question": "What is associated with Increased circulating interleukin 13 concentration?",
    "seeds": [
      "Increased circulating interleukin 13 concentration"
    ],
    "gold_answer": "Abnormal circulating interleukin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09688",
    "question": "What is associated with History of recent contralateral injury?",
    "seeds": [
      "History of recent contralateral injury"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09689",
    "question": "What is associated with Abnormal ureter physiology?",
    "seeds": [
      "Abnormal ureter physiology"
    ],
    "gold_answer": "Abnormality of the ureter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09690",
    "question": "What phenotype is associated with Porphyria, congenital erythropoietic?",
    "seeds": [
      "Porphyria, congenital erythropoietic"
    ],
    "gold_answer": "Hypertrichosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09691",
    "question": "What is associated with Abnormal coagulation factor V activity?",
    "seeds": [
      "Abnormal coagulation factor V activity"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09692",
    "question": "What is associated with Complete duplication of the phalanges of the 2nd finger?",
    "seeds": [
      "Complete duplication of the phalanges of the 2nd finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09693",
    "question": "What is associated with Papillomatosis, familial cutaneous?",
    "seeds": [
      "Papillomatosis, familial cutaneous"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09694",
    "question": "What is associated with Pneumocystosis?",
    "seeds": [
      "Pneumocystosis"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09695",
    "question": "What is associated with Focal impaired awareness emotional seizure with crying?",
    "seeds": [
      "Focal impaired awareness emotional seizure with crying"
    ],
    "gold_answer": "Focal impaired awareness emotional seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09696",
    "question": "What is associated with Abnormal middle ear reflexes?",
    "seeds": [
      "Abnormal middle ear reflexes"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09697",
    "question": "What is associated with Angelman syndrome due to maternal 15q11q13 deletion?",
    "seeds": [
      "Angelman syndrome due to maternal 15q11q13 deletion"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09698",
    "question": "What phenotype is associated with Mucopolysaccharidosis type IX?",
    "seeds": [
      "Mucopolysaccharidosis type IX"
    ],
    "gold_answer": "Ankle pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09699",
    "question": "What is associated with Hyperpigmented nevi and streak?",
    "seeds": [
      "Hyperpigmented nevi and streak"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09700",
    "question": "What is associated with Anomalous origin of right coronary artery from the pulmonary artery?",
    "seeds": [
      "Anomalous origin of right coronary artery from the pulmonary artery"
    ],
    "gold_answer": "Abnormal coronary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09701",
    "question": "What phenotype is associated with Myasthenic syndrome, congenital, with tubular aggregates 1?",
    "seeds": [
      "Myasthenic syndrome, congenital, with tubular aggregates 1"
    ],
    "gold_answer": "Ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09702",
    "question": "What is associated with Retinal dystrophy with or without macular staphyloma?",
    "seeds": [
      "Retinal dystrophy with or without macular staphyloma"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09703",
    "question": "What is associated with Abnormal circulating pyrimidine concentration?",
    "seeds": [
      "Abnormal circulating pyrimidine concentration"
    ],
    "gold_answer": "Abnormal circulating nucleobase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09704",
    "question": "What is associated with Abnormal labia minora morphology?",
    "seeds": [
      "Abnormal labia minora morphology"
    ],
    "gold_answer": "Abnormal labia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09705",
    "question": "What is associated with Hemangiomatosis?",
    "seeds": [
      "Hemangiomatosis"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09706",
    "question": "What phenotype is associated with Transient erythroblastopenia of childhood?",
    "seeds": [
      "Transient erythroblastopenia of childhood"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09707",
    "question": "What is associated with Acephalic spermatozoa?",
    "seeds": [
      "Acephalic spermatozoa"
    ],
    "gold_answer": "Abnormal sperm head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09708",
    "question": "What is associated with Renal interstitial IgG4+ plasma cell infiltration?",
    "seeds": [
      "Renal interstitial IgG4+ plasma cell infiltration"
    ],
    "gold_answer": "Abnormal renal interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09709",
    "question": "What is associated with Colobomatous microphthalmia-rhizomelic dysplasia syndrome?",
    "seeds": [
      "Colobomatous microphthalmia-rhizomelic dysplasia syndrome"
    ],
    "gold_answer": "MAB21L2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09710",
    "question": "What is associated with Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness?",
    "seeds": [
      "Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09711",
    "question": "What is associated with Anterior cutaneous nerve entrapment syndrome?",
    "seeds": [
      "Anterior cutaneous nerve entrapment syndrome"
    ],
    "gold_answer": "Hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09712",
    "question": "What is associated with Mitochondrial phosphate carrier deficiency?",
    "seeds": [
      "Mitochondrial phosphate carrier deficiency"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09713",
    "question": "What is associated with Aspiration?",
    "seeds": [
      "Aspiration"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09714",
    "question": "What is associated with Aphasia?",
    "seeds": [
      "Aphasia"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09715",
    "question": "What is associated with Calvarial doughnut lesions with bone fragility?",
    "seeds": [
      "Calvarial doughnut lesions with bone fragility"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09716",
    "question": "What is associated with Irregular epiphyses of the 3rd finger?",
    "seeds": [
      "Irregular epiphyses of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09717",
    "question": "What is associated with Meige disease?",
    "seeds": [
      "Meige disease"
    ],
    "gold_answer": "Abnormal pleura morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09718",
    "question": "What is associated with Conus terminalis arteriovenous malformation?",
    "seeds": [
      "Conus terminalis arteriovenous malformation"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09719",
    "question": "What is associated with Hyperapobetalipoproteinemia?",
    "seeds": [
      "Hyperapobetalipoproteinemia"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09720",
    "question": "What is associated with Early balding?",
    "seeds": [
      "Early balding"
    ],
    "gold_answer": "Acquired abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09721",
    "question": "What is associated with Spermatogenic failure, Y-linked, 2?",
    "seeds": [
      "Spermatogenic failure, Y-linked, 2"
    ],
    "gold_answer": "Abnormal spermatogenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09722",
    "question": "What is associated with Abnormal foveal pit on macular OCT?",
    "seeds": [
      "Abnormal foveal pit on macular OCT"
    ],
    "gold_answer": "Abnormal optical coherence tomography",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09723",
    "question": "What is associated with Dairy allergy?",
    "seeds": [
      "Dairy allergy"
    ],
    "gold_answer": "Allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09724",
    "question": "What phenotype is associated with Immunodeficiency 102?",
    "seeds": [
      "Immunodeficiency 102"
    ],
    "gold_answer": "Chronic rhinitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09725",
    "question": "What is associated with White matter hypoplasia-corpus callosum agenesis-intellectual disability syndrome?",
    "seeds": [
      "White matter hypoplasia-corpus callosum agenesis-intellectual disability syndrome"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09726",
    "question": "What is associated with Narrow greater sciatic notch?",
    "seeds": [
      "Narrow greater sciatic notch"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09727",
    "question": "What is associated with Abnormal vaginal physiology?",
    "seeds": [
      "Abnormal vaginal physiology"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09728",
    "question": "What is associated with Osteolysis involving bones of the lower limbs?",
    "seeds": [
      "Osteolysis involving bones of the lower limbs"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09729",
    "question": "What is associated with Decreased cardiac index?",
    "seeds": [
      "Decreased cardiac index"
    ],
    "gold_answer": "Abnormal cardiac output",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09730",
    "question": "What is associated with Tendons, extensor, of fingers, anomalous insertion of?",
    "seeds": [
      "Tendons, extensor, of fingers, anomalous insertion of"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09731",
    "question": "What is associated with Naevus flammeus of the eyelid?",
    "seeds": [
      "Naevus flammeus of the eyelid"
    ],
    "gold_answer": "Nevus flammeus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09732",
    "question": "What is associated with Areas of hypopigmentation and hyperpigmentation that follow Blaschko lines?",
    "seeds": [
      "Areas of hypopigmentation and hyperpigmentation that follow Blaschko lines"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09733",
    "question": "What is associated with Pericardial effusion?",
    "seeds": [
      "Pericardial effusion"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09734",
    "question": "What is associated with Spondylometaphyseal dysplasia, axial?",
    "seeds": [
      "Spondylometaphyseal dysplasia, axial"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09735",
    "question": "What is associated with Acrofacial dysostosis 1, Nager type?",
    "seeds": [
      "Acrofacial dysostosis 1, Nager type"
    ],
    "gold_answer": "Abnormal nasal bridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09736",
    "question": "What is associated with Wrist instability?",
    "seeds": [
      "Wrist instability"
    ],
    "gold_answer": "Abnormal wrist physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09737",
    "question": "What is associated with Glenoid fracture?",
    "seeds": [
      "Glenoid fracture"
    ],
    "gold_answer": "Fractured shoulder bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09738",
    "question": "What is associated with Decreased forced expiratory flow 25-75%?",
    "seeds": [
      "Decreased forced expiratory flow 25-75%"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09739",
    "question": "What is associated with Masseter muscular weakness?",
    "seeds": [
      "Masseter muscular weakness"
    ],
    "gold_answer": "Abnormal oral physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09740",
    "question": "What is associated with Nasal chondritis?",
    "seeds": [
      "Nasal chondritis"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09741",
    "question": "What is associated with Tubular accumulation of uromodulin?",
    "seeds": [
      "Tubular accumulation of uromodulin"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09742",
    "question": "What phenotype is associated with Myopathy with extrapyramidal signs?",
    "seeds": [
      "Myopathy with extrapyramidal signs"
    ],
    "gold_answer": "Gastroesophageal reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09743",
    "question": "What phenotype is associated with Greenberg dysplasia?",
    "seeds": [
      "Greenberg dysplasia"
    ],
    "gold_answer": "Micromelia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09744",
    "question": "What is associated with Seizures, scoliosis, and macrocephaly/microcephaly syndrome?",
    "seeds": [
      "Seizures, scoliosis, and macrocephaly/microcephaly syndrome"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09745",
    "question": "What is associated with Bicornuate uterus?",
    "seeds": [
      "Bicornuate uterus"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09746",
    "question": "What is associated with Elevated CSF myelin basic protein concentration?",
    "seeds": [
      "Elevated CSF myelin basic protein concentration"
    ],
    "gold_answer": "Abnormal CSF protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09747",
    "question": "What is associated with Palatopharyngeal incompetence?",
    "seeds": [
      "Palatopharyngeal incompetence"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09748",
    "question": "What is associated with Nodular-centrilobular without tree-in-bud pattern on pulmonary HRCT?",
    "seeds": [
      "Nodular-centrilobular without tree-in-bud pattern on pulmonary HRCT"
    ],
    "gold_answer": "Pulmonary interstitial high-resolution computed tomography abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09749",
    "question": "What is associated with Juvenile absence epilepsy?",
    "seeds": [
      "Juvenile absence epilepsy"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09750",
    "question": "What is associated with Inappropriate antidiuretic hormone secretion?",
    "seeds": [
      "Inappropriate antidiuretic hormone secretion"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09751",
    "question": "What is associated with Non-insulinoma pancreatogenous hypoglycemia syndrome?",
    "seeds": [
      "Non-insulinoma pancreatogenous hypoglycemia syndrome"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09752",
    "question": "What phenotype is associated with Systemic capillary leak syndrome?",
    "seeds": [
      "Systemic capillary leak syndrome"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09753",
    "question": "What is associated with Pituitary blastoma?",
    "seeds": [
      "Pituitary blastoma"
    ],
    "gold_answer": "Neoplasm of the pituitary gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09754",
    "question": "What is associated with Hypoplasia of serratus anterior muscle?",
    "seeds": [
      "Hypoplasia of serratus anterior muscle"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09755",
    "question": "What is associated with Partial-complete absence of 5th phalanges?",
    "seeds": [
      "Partial-complete absence of 5th phalanges"
    ],
    "gold_answer": "Abnormal 5th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09756",
    "question": "What is associated with Cone-Rod dystrophy 16?",
    "seeds": [
      "Cone-Rod dystrophy 16"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09757",
    "question": "What phenotype is associated with Hypothyroidism, congenital, nongoitrous, 4?",
    "seeds": [
      "Hypothyroidism, congenital, nongoitrous, 4"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09758",
    "question": "What phenotype is associated with X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome?",
    "seeds": [
      "X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome"
    ],
    "gold_answer": "Protruding ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09759",
    "question": "What is associated with Ascending aortic dissection?",
    "seeds": [
      "Ascending aortic dissection"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09760",
    "question": "What is associated with Paroxysmal atrial tachycardia?",
    "seeds": [
      "Paroxysmal atrial tachycardia"
    ],
    "gold_answer": "Supraventricular tachycardia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09761",
    "question": "What is associated with Generalized neonatal hypotonia?",
    "seeds": [
      "Generalized neonatal hypotonia"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09762",
    "question": "What is associated with Bile duct proliferation?",
    "seeds": [
      "Bile duct proliferation"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09763",
    "question": "What phenotype is associated with Oculocerebral syndrome with hypopigmentation?",
    "seeds": [
      "Oculocerebral syndrome with hypopigmentation"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09764",
    "question": "What is associated with Axial dystonia?",
    "seeds": [
      "Axial dystonia"
    ],
    "gold_answer": "Dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09765",
    "question": "What is associated with Arcuate scotoma?",
    "seeds": [
      "Arcuate scotoma"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09766",
    "question": "What is associated with Aspirin-induced asthma?",
    "seeds": [
      "Aspirin-induced asthma"
    ],
    "gold_answer": "Asthma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09767",
    "question": "What is associated with Thrombocytopenic purpura, autoimmune?",
    "seeds": [
      "Thrombocytopenic purpura, autoimmune"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09768",
    "question": "What is associated with Hypoammonemia?",
    "seeds": [
      "Hypoammonemia"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09769",
    "question": "What phenotype is associated with Alopecia-intellectual disability syndrome 1?",
    "seeds": [
      "Alopecia-intellectual disability syndrome 1"
    ],
    "gold_answer": "Alopecia universalis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09770",
    "question": "What is associated with Vaginal mass?",
    "seeds": [
      "Vaginal mass"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09771",
    "question": "What is associated with Recurrent Burkholderia cepacia infections?",
    "seeds": [
      "Recurrent Burkholderia cepacia infections"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09772",
    "question": "What is associated with Increased tear production?",
    "seeds": [
      "Increased tear production"
    ],
    "gold_answer": "Epiphora",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09773",
    "question": "What is associated with Abnormal renal interstitial morphology?",
    "seeds": [
      "Abnormal renal interstitial morphology"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09774",
    "question": "What is associated with Interosseus muscle atrophy?",
    "seeds": [
      "Interosseus muscle atrophy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09775",
    "question": "What is associated with Nasal secretion eosinophilia?",
    "seeds": [
      "Nasal secretion eosinophilia"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09776",
    "question": "What is associated with Acromelic frontonasal dysplasia?",
    "seeds": [
      "Acromelic frontonasal dysplasia"
    ],
    "gold_answer": "Talipes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09777",
    "question": "What is associated with Reduced insulin-like factor 3 level?",
    "seeds": [
      "Reduced insulin-like factor 3 level"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09778",
    "question": "What is associated with Photoreceptor outer segment loss on macular OCT?",
    "seeds": [
      "Photoreceptor outer segment loss on macular OCT"
    ],
    "gold_answer": "Abnormal posterior segment imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09779",
    "question": "What phenotype is associated with Ceroid lipofuscinosis, neuronal, 10?",
    "seeds": [
      "Ceroid lipofuscinosis, neuronal, 10"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09780",
    "question": "What is associated with Elevated urinary N-butyrylglycine?",
    "seeds": [
      "Elevated urinary N-butyrylglycine"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09781",
    "question": "What is associated with Focal cortical dysplasia type Ib?",
    "seeds": [
      "Focal cortical dysplasia type Ib"
    ],
    "gold_answer": "Focal cortical dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09782",
    "question": "What is associated with Nail pits?",
    "seeds": [
      "Nail pits"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09783",
    "question": "What is associated with Dysregulated negative emotional state?",
    "seeds": [
      "Dysregulated negative emotional state"
    ],
    "gold_answer": "Abnormal emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09784",
    "question": "What is associated with Cortical radial artery medial/intimal arteriitis?",
    "seeds": [
      "Cortical radial artery medial/intimal arteriitis"
    ],
    "gold_answer": "Abnormal cortical radial artery intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09785",
    "question": "What phenotype is associated with Neurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiency?",
    "seeds": [
      "Neurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiency"
    ],
    "gold_answer": "Encephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09786",
    "question": "What phenotype is associated with Beta-ureidopropionase deficiency?",
    "seeds": [
      "Beta-ureidopropionase deficiency"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09787",
    "question": "What is associated with Congenital Horner syndrome?",
    "seeds": [
      "Congenital Horner syndrome"
    ],
    "gold_answer": "Horner syndrome",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09788",
    "question": "What phenotype is associated with Cortical blindness-intellectual disability-polydactyly syndrome?",
    "seeds": [
      "Cortical blindness-intellectual disability-polydactyly syndrome"
    ],
    "gold_answer": "Long philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09789",
    "question": "What is associated with Abnormal lung morphology?",
    "seeds": [
      "Abnormal lung morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09790",
    "question": "What is associated with Cervical clear cell adenocarcinoma?",
    "seeds": [
      "Cervical clear cell adenocarcinoma"
    ],
    "gold_answer": "Abnormal vagina morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09791",
    "question": "What is associated with Renal arteriolar lumen cholesterol emboli?",
    "seeds": [
      "Renal arteriolar lumen cholesterol emboli"
    ],
    "gold_answer": "Abnormal renal arteriole lumen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09792",
    "question": "What is associated with Elevated urine guanidinoacetic acid level?",
    "seeds": [
      "Elevated urine guanidinoacetic acid level"
    ],
    "gold_answer": "Increased urine proteinogenic amino acid derivative level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09793",
    "question": "What is associated with Prolonged G2 phase of cell cycle?",
    "seeds": [
      "Prolonged G2 phase of cell cycle"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09794",
    "question": "What is associated with Ritscher-Schinzel syndrome 2?",
    "seeds": [
      "Ritscher-Schinzel syndrome 2"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09795",
    "question": "What is associated with Synostosis involving the 1st metacarpal?",
    "seeds": [
      "Synostosis involving the 1st metacarpal"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09796",
    "question": "What is associated with Achondrogenesis?",
    "seeds": [
      "Achondrogenesis"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09797",
    "question": "What is associated with Unaided visual acuity 0.5 LogMAR?",
    "seeds": [
      "Unaided visual acuity 0.5 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09798",
    "question": "What phenotype is associated with Multiple synostoses syndrome 4?",
    "seeds": [
      "Multiple synostoses syndrome 4"
    ],
    "gold_answer": "Broad foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09799",
    "question": "What is associated with Premature adrenarche?",
    "seeds": [
      "Premature adrenarche"
    ],
    "gold_answer": "Early onset of sexual maturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09800",
    "question": "What phenotype is associated with Urachal sinus?",
    "seeds": [
      "Urachal sinus"
    ],
    "gold_answer": "Abdominal pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09801",
    "question": "What phenotype is associated with Deafness, autosomal dominant 83?",
    "seeds": [
      "Deafness, autosomal dominant 83"
    ],
    "gold_answer": "Bilateral sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09802",
    "question": "What is associated with Immunodeficiency 72 with autoinflammation?",
    "seeds": [
      "Immunodeficiency 72 with autoinflammation"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09803",
    "question": "What is associated with Paroxysmal nonkinesigenic dyskinesia 1?",
    "seeds": [
      "Paroxysmal nonkinesigenic dyskinesia 1"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09804",
    "question": "What is associated with X-linked reticulate pigmentary disorder?",
    "seeds": [
      "X-linked reticulate pigmentary disorder"
    ],
    "gold_answer": "POLA1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_09805",
    "question": "What is associated with Paraplegia-intellectual disability-hyperkeratosis syndrome?",
    "seeds": [
      "Paraplegia-intellectual disability-hyperkeratosis syndrome"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09806",
    "question": "What is associated with Sclerotic foci of humeral diaphysis?",
    "seeds": [
      "Sclerotic foci of humeral diaphysis"
    ],
    "gold_answer": "Abnormal humeral diaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09807",
    "question": "What is associated with Upper-limb joint contracture?",
    "seeds": [
      "Upper-limb joint contracture"
    ],
    "gold_answer": "Joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09808",
    "question": "What is associated with Neurodevelopmental disorder with seizures, hypotonia, and variable spasticity?",
    "seeds": [
      "Neurodevelopmental disorder with seizures, hypotonia, and variable spasticity"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09809",
    "question": "What phenotype is associated with Unstable beta globin chain variant disease?",
    "seeds": [
      "Unstable beta globin chain variant disease"
    ],
    "gold_answer": "Arthralgia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09810",
    "question": "What is associated with Anti-GFAP antibody?",
    "seeds": [
      "Anti-GFAP antibody"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09811",
    "question": "What is associated with Bent long bone?",
    "seeds": [
      "Bent long bone"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09812",
    "question": "What is associated with Asymmetry of the mandible?",
    "seeds": [
      "Asymmetry of the mandible"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09813",
    "question": "What is associated with Calcified placenta?",
    "seeds": [
      "Calcified placenta"
    ],
    "gold_answer": "Abnormal placenta morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09814",
    "question": "What phenotype is associated with Brachydactyly-syndactyly, Zhao type?",
    "seeds": [
      "Brachydactyly-syndactyly, Zhao type"
    ],
    "gold_answer": "Symphalangism affecting the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09815",
    "question": "What phenotype is associated with Cardiac valvular dysplasia 2?",
    "seeds": [
      "Cardiac valvular dysplasia 2"
    ],
    "gold_answer": "Pulmonic stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09816",
    "question": "What is associated with Hypovolemia?",
    "seeds": [
      "Hypovolemia"
    ],
    "gold_answer": "Abnormality of blood volume homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09817",
    "question": "What is associated with Notched primary central incisor?",
    "seeds": [
      "Notched primary central incisor"
    ],
    "gold_answer": "Abnormality of the incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09818",
    "question": "What is associated with McDonough syndrome?",
    "seeds": [
      "McDonough syndrome"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09819",
    "question": "What is associated with Cerebral palsy, ataxic, autosomal recessive?",
    "seeds": [
      "Cerebral palsy, ataxic, autosomal recessive"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09820",
    "question": "What is associated with Anti-neuromuscular Junction acetylcholine receptor antibody positivity?",
    "seeds": [
      "Anti-neuromuscular Junction acetylcholine receptor antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09821",
    "question": "What is associated with Neutrophilic dermatosis, acute febrile?",
    "seeds": [
      "Neutrophilic dermatosis, acute febrile"
    ],
    "gold_answer": "Abnormal circulating C-reactive protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09822",
    "question": "What is associated with Mitochondrial DNA depletion syndrome 20 (MNGIE type)?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 20 (MNGIE type)"
    ],
    "gold_answer": "Abnormal esophagus physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09823",
    "question": "What phenotype is associated with Epidermolytic hyperkeratosis 2?",
    "seeds": [
      "Epidermolytic hyperkeratosis 2"
    ],
    "gold_answer": "Congenital nonbullous ichthyosiform erythroderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09824",
    "question": "What is associated with Sudden infant death-dysgenesis of the testes syndrome?",
    "seeds": [
      "Sudden infant death-dysgenesis of the testes syndrome"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09825",
    "question": "What is associated with Increased urinary sulfite level?",
    "seeds": [
      "Increased urinary sulfite level"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09826",
    "question": "What is associated with Combined immunodeficiency due to RELB deficiency?",
    "seeds": [
      "Combined immunodeficiency due to RELB deficiency"
    ],
    "gold_answer": "RELB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_09827",
    "question": "What is associated with Facial diplegia?",
    "seeds": [
      "Facial diplegia"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09828",
    "question": "What is associated with Ceroid lipofuscinosis, neuronal, 10?",
    "seeds": [
      "Ceroid lipofuscinosis, neuronal, 10"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09829",
    "question": "What is associated with Substantia nigra dopaminergic neuron loss?",
    "seeds": [
      "Substantia nigra dopaminergic neuron loss"
    ],
    "gold_answer": "Abnormal substantia nigra morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09830",
    "question": "What is associated with Partial duplication of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Partial duplication of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09831",
    "question": "What is associated with Reduced peroxisomal glutaryl-CoA oxidase activity?",
    "seeds": [
      "Reduced peroxisomal glutaryl-CoA oxidase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09832",
    "question": "What is associated with Tubular aggregate myopathy?",
    "seeds": [
      "Tubular aggregate myopathy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09833",
    "question": "What is associated with Poikiloderma, hereditary sclerosing?",
    "seeds": [
      "Poikiloderma, hereditary sclerosing"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09834",
    "question": "What is associated with Cerebellar ataxia associated with quadrupedal gait?",
    "seeds": [
      "Cerebellar ataxia associated with quadrupedal gait"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09835",
    "question": "What phenotype is associated with Sporadic fetal brain disruption sequence?",
    "seeds": [
      "Sporadic fetal brain disruption sequence"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09836",
    "question": "What phenotype is associated with Immunodeficiency 47?",
    "seeds": [
      "Immunodeficiency 47"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09837",
    "question": "What is associated with Thyroid crisis?",
    "seeds": [
      "Thyroid crisis"
    ],
    "gold_answer": "Hyperthyroidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09838",
    "question": "What is associated with Abnormal erythrocyte enzyme concentration or activity?",
    "seeds": [
      "Abnormal erythrocyte enzyme concentration or activity"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09839",
    "question": "What is associated with Renal tubular herpes simplex virus inclusions?",
    "seeds": [
      "Renal tubular herpes simplex virus inclusions"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09840",
    "question": "What phenotype is associated with Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 5?",
    "seeds": [
      "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 5"
    ],
    "gold_answer": "Dysphonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09841",
    "question": "What is associated with Fractured patella?",
    "seeds": [
      "Fractured patella"
    ],
    "gold_answer": "Fractured hindlimb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09842",
    "question": "What is associated with Absent muscle fiber merosin?",
    "seeds": [
      "Absent muscle fiber merosin"
    ],
    "gold_answer": "Abnormal muscle fiber merosin expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09843",
    "question": "What is associated with Giant cell granuloma of mandible?",
    "seeds": [
      "Giant cell granuloma of mandible"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09844",
    "question": "What is associated with Complete duplication of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Complete duplication of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Complete duplication of the phalanges of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09845",
    "question": "What phenotype is associated with Immunodeficiency 89 and autoimmunity?",
    "seeds": [
      "Immunodeficiency 89 and autoimmunity"
    ],
    "gold_answer": "Reduced circulating interleukin 10 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09846",
    "question": "What is associated with Recurrent meningitis?",
    "seeds": [
      "Recurrent meningitis"
    ],
    "gold_answer": "Unusual CNS infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09847",
    "question": "What is associated with Hengel-Maroofian-Schols syndrome?",
    "seeds": [
      "Hengel-Maroofian-Schols syndrome"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09848",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type Ij?",
    "seeds": [
      "Congenital disorder of glycosylation, type Ij"
    ],
    "gold_answer": "Reduced antithrombin III activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09849",
    "question": "What is associated with Therapeutic abortion?",
    "seeds": [
      "Therapeutic abortion"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09850",
    "question": "What is associated with Skin-picking?",
    "seeds": [
      "Skin-picking"
    ],
    "gold_answer": "Self-injurious behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09851",
    "question": "What phenotype is associated with Pterygium colli-intellectual disability-digital anomalies syndrome?",
    "seeds": [
      "Pterygium colli-intellectual disability-digital anomalies syndrome"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09852",
    "question": "What is associated with Epidermodysplasia verruciformis, susceptibility to, 5?",
    "seeds": [
      "Epidermodysplasia verruciformis, susceptibility to, 5"
    ],
    "gold_answer": "Abnormal leukocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09853",
    "question": "What is associated with Mobitz II atrioventricular block?",
    "seeds": [
      "Mobitz II atrioventricular block"
    ],
    "gold_answer": "Abnormal atrioventricular conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09854",
    "question": "What is associated with Abnormal 5th finger phalanx morphology?",
    "seeds": [
      "Abnormal 5th finger phalanx morphology"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09855",
    "question": "What is associated with Frontal polymicrogyria?",
    "seeds": [
      "Frontal polymicrogyria"
    ],
    "gold_answer": "Abnormal cortical gyration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09856",
    "question": "What is associated with Sensory exotropia?",
    "seeds": [
      "Sensory exotropia"
    ],
    "gold_answer": "Exotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09857",
    "question": "What is associated with Female sexual dysfunction?",
    "seeds": [
      "Female sexual dysfunction"
    ],
    "gold_answer": "Abnormal female reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09858",
    "question": "What is associated with Slanting of the palpebral fissure?",
    "seeds": [
      "Slanting of the palpebral fissure"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09859",
    "question": "What is associated with Short REM sleep?",
    "seeds": [
      "Short REM sleep"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09860",
    "question": "What is associated with Osteolytic defects of the phalanges of the 4th toe?",
    "seeds": [
      "Osteolytic defects of the phalanges of the 4th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09861",
    "question": "What is associated with Abnormal enteric neuron morphology?",
    "seeds": [
      "Abnormal enteric neuron morphology"
    ],
    "gold_answer": "Abnormal enteric nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09862",
    "question": "What phenotype is associated with Hydatidiform mole, recurrent, 3?",
    "seeds": [
      "Hydatidiform mole, recurrent, 3"
    ],
    "gold_answer": "Hydatidiform mole",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09863",
    "question": "What is associated with Small intestinal adenoma?",
    "seeds": [
      "Small intestinal adenoma"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09864",
    "question": "What is associated with Actinomyopathy-associated syndromic thrombocytopenia?",
    "seeds": [
      "Actinomyopathy-associated syndromic thrombocytopenia"
    ],
    "gold_answer": "ACTB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09865",
    "question": "What is associated with Elevated circulating calprotectin concentration?",
    "seeds": [
      "Elevated circulating calprotectin concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09866",
    "question": "What phenotype is associated with Peroxisomal fatty acyl-CoA reductase 1 disorder?",
    "seeds": [
      "Peroxisomal fatty acyl-CoA reductase 1 disorder"
    ],
    "gold_answer": "Cerebral atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09867",
    "question": "What is associated with Abnormal renal tubular epithelial morphology?",
    "seeds": [
      "Abnormal renal tubular epithelial morphology"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09868",
    "question": "What is associated with Abnormal right ventricle morphology?",
    "seeds": [
      "Abnormal right ventricle morphology"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09869",
    "question": "What is associated with Enlarged epiphysis of the middle phalanx of the 4th toe?",
    "seeds": [
      "Enlarged epiphysis of the middle phalanx of the 4th toe"
    ],
    "gold_answer": "Enlarged epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09870",
    "question": "What is associated with Late-onset retinal degeneration?",
    "seeds": [
      "Late-onset retinal degeneration"
    ],
    "gold_answer": "C1QTNF5",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09871",
    "question": "What is associated with Rouleaux formation?",
    "seeds": [
      "Rouleaux formation"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09872",
    "question": "What is associated with Bullet-shaped proximal phalanx of the 4th finger?",
    "seeds": [
      "Bullet-shaped proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09873",
    "question": "What is associated with Aminoacylase 1 deficiency?",
    "seeds": [
      "Aminoacylase 1 deficiency"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09874",
    "question": "What is associated with Pelizaeus-Merzbacher disease in female carriers?",
    "seeds": [
      "Pelizaeus-Merzbacher disease in female carriers"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09875",
    "question": "What is associated with Onychogryphosis of toenails?",
    "seeds": [
      "Onychogryphosis of toenails"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09876",
    "question": "What phenotype is associated with Epilepsy, familial adult myoclonic, 1?",
    "seeds": [
      "Epilepsy, familial adult myoclonic, 1"
    ],
    "gold_answer": "Jerk-locked premyoclonus spikes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09877",
    "question": "What is associated with Chronic acidosis?",
    "seeds": [
      "Chronic acidosis"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09878",
    "question": "What is associated with Ehlers-Danlos syndrome with platelet dysfunction from fibronectin abnormality?",
    "seeds": [
      "Ehlers-Danlos syndrome with platelet dysfunction from fibronectin abnormality"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09879",
    "question": "What is associated with Elevated circulating deoxypyridinoline concentration?",
    "seeds": [
      "Elevated circulating deoxypyridinoline concentration"
    ],
    "gold_answer": "Abnormal circulating collagen degradation product concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09880",
    "question": "What is associated with Mammary duct ectasia?",
    "seeds": [
      "Mammary duct ectasia"
    ],
    "gold_answer": "Abnormal breast morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09881",
    "question": "What is associated with Anomalous origin of the left common carotid artery from the main pulmonary artery?",
    "seeds": [
      "Anomalous origin of the left common carotid artery from the main pulmonary artery"
    ],
    "gold_answer": "Abnormal common carotid artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09882",
    "question": "What is associated with Steatorrhea?",
    "seeds": [
      "Steatorrhea"
    ],
    "gold_answer": "Fat malabsorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09883",
    "question": "What is associated with Hengel-Maroofian-Schols syndrome?",
    "seeds": [
      "Hengel-Maroofian-Schols syndrome"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09884",
    "question": "What is associated with Rhizomelic arm shortening?",
    "seeds": [
      "Rhizomelic arm shortening"
    ],
    "gold_answer": "Limb undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09885",
    "question": "What is associated with Decreased QRS voltage?",
    "seeds": [
      "Decreased QRS voltage"
    ],
    "gold_answer": "Abnormal QRS complex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09886",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 76?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 76"
    ],
    "gold_answer": "Early onset of sexual maturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09887",
    "question": "What is associated with Hypoparathyroidism-retardation-dysmorphism syndrome?",
    "seeds": [
      "Hypoparathyroidism-retardation-dysmorphism syndrome"
    ],
    "gold_answer": "Abnormal location of ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09888",
    "question": "What is associated with Hydrolethalus syndrome 2?",
    "seeds": [
      "Hydrolethalus syndrome 2"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09889",
    "question": "What is associated with Immune defect due to absence of thymus?",
    "seeds": [
      "Immune defect due to absence of thymus"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09890",
    "question": "What is associated with Dementia?",
    "seeds": [
      "Dementia"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09891",
    "question": "What is associated with Reduced muscle carnitine level?",
    "seeds": [
      "Reduced muscle carnitine level"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09892",
    "question": "What is associated with Occupational exposure to frequent kneeling?",
    "seeds": [
      "Occupational exposure to frequent kneeling"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09893",
    "question": "What is associated with Triangular epiphysis of the 1st metacarpal?",
    "seeds": [
      "Triangular epiphysis of the 1st metacarpal"
    ],
    "gold_answer": "Abnormality of thumb epiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09894",
    "question": "What is associated with Ichthyosis-prematurity syndrome?",
    "seeds": [
      "Ichthyosis-prematurity syndrome"
    ],
    "gold_answer": "Respiratory insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09895",
    "question": "What is associated with Deafness, autosomal dominant 23?",
    "seeds": [
      "Deafness, autosomal dominant 23"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09896",
    "question": "What is associated with Hypoplastic acetabulae?",
    "seeds": [
      "Hypoplastic acetabulae"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09897",
    "question": "What phenotype is associated with TRACHEOBRONCHOMEGALY?",
    "seeds": [
      "TRACHEOBRONCHOMEGALY"
    ],
    "gold_answer": "Recurrent bronchopulmonary infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09898",
    "question": "What is associated with Bilineage myelodysplasia?",
    "seeds": [
      "Bilineage myelodysplasia"
    ],
    "gold_answer": "Myelodysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09899",
    "question": "What phenotype is associated with Lissencephaly type 3-metacarpal bone dysplasia syndrome?",
    "seeds": [
      "Lissencephaly type 3-metacarpal bone dysplasia syndrome"
    ],
    "gold_answer": "Pulmonary hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09900",
    "question": "What is associated with Bracket epiphyses of the 5th toe?",
    "seeds": [
      "Bracket epiphyses of the 5th toe"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09901",
    "question": "What is associated with Reduced tendon reflexes?",
    "seeds": [
      "Reduced tendon reflexes"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09902",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanx of the 5th toe?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the distal phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09903",
    "question": "What is associated with Central diabetes insipidus?",
    "seeds": [
      "Central diabetes insipidus"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09904",
    "question": "What phenotype is associated with Adrenocortical carcinoma, pediatric?",
    "seeds": [
      "Adrenocortical carcinoma, pediatric"
    ],
    "gold_answer": "Adrenocortical carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09905",
    "question": "What is associated with Biconcave vertebral bodies?",
    "seeds": [
      "Biconcave vertebral bodies"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09906",
    "question": "What is associated with Plantar flexion contracture?",
    "seeds": [
      "Plantar flexion contracture"
    ],
    "gold_answer": "Lower-limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09907",
    "question": "What is associated with Microphthalmia, syndromic 3?",
    "seeds": [
      "Microphthalmia, syndromic 3"
    ],
    "gold_answer": "Congenital malformation of the great arteries",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09908",
    "question": "What is associated with Rolandic epilepsy-paroxysmal exercise-induced dystonia-writer's cramp syndrome?",
    "seeds": [
      "Rolandic epilepsy-paroxysmal exercise-induced dystonia-writer's cramp syndrome"
    ],
    "gold_answer": "EEG with parietal epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09909",
    "question": "What is associated with Neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosum?",
    "seeds": [
      "Neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosum"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09910",
    "question": "What is associated with Vestibulocochlear dysfunction, progressive?",
    "seeds": [
      "Vestibulocochlear dysfunction, progressive"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09911",
    "question": "What is associated with Freckles in sun-exposed areas?",
    "seeds": [
      "Freckles in sun-exposed areas"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09912",
    "question": "What phenotype is associated with Turner syndrome?",
    "seeds": [
      "Turner syndrome"
    ],
    "gold_answer": "Micrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09913",
    "question": "What is associated with Infantile nephropathic cystinosis?",
    "seeds": [
      "Infantile nephropathic cystinosis"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09914",
    "question": "What is associated with Dysplastic tricuspid valve?",
    "seeds": [
      "Dysplastic tricuspid valve"
    ],
    "gold_answer": "Abnormal heart valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09915",
    "question": "What is associated with Protrusio acetabuli?",
    "seeds": [
      "Protrusio acetabuli"
    ],
    "gold_answer": "Lower-limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09916",
    "question": "What is associated with Abnormal psychotic pattern?",
    "seeds": [
      "Abnormal psychotic pattern"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09917",
    "question": "What is associated with Familial Alzheimer-like prion disease?",
    "seeds": [
      "Familial Alzheimer-like prion disease"
    ],
    "gold_answer": "Memory impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09918",
    "question": "What is associated with Multiple pterygia?",
    "seeds": [
      "Multiple pterygia"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09919",
    "question": "What is associated with HbS hemoglobin?",
    "seeds": [
      "HbS hemoglobin"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09920",
    "question": "What phenotype is associated with Brachydactyly, type e, with atrial septal defect, type II?",
    "seeds": [
      "Brachydactyly, type e, with atrial septal defect, type II"
    ],
    "gold_answer": "Atrial septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09921",
    "question": "What is associated with Decreased erythrocyte nicotinamide adenine dinucleotide-cytochrome b5 reductase activity?",
    "seeds": [
      "Decreased erythrocyte nicotinamide adenine dinucleotide-cytochrome b5 reductase activity"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09922",
    "question": "What is associated with Primary unilateral adrenal hyperplasia?",
    "seeds": [
      "Primary unilateral adrenal hyperplasia"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09923",
    "question": "What is associated with Ichthyosis?",
    "seeds": [
      "Ichthyosis"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09924",
    "question": "What is associated with Generalized myoclonic-atonic seizure?",
    "seeds": [
      "Generalized myoclonic-atonic seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09925",
    "question": "What is associated with Abnormal toe morphology?",
    "seeds": [
      "Abnormal toe morphology"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09926",
    "question": "What phenotype is associated with White sponge nevus 2?",
    "seeds": [
      "White sponge nevus 2"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09927",
    "question": "What is associated with Cortical peritubular capillary intraluminal thrombi?",
    "seeds": [
      "Cortical peritubular capillary intraluminal thrombi"
    ],
    "gold_answer": "Abnormal cortical peritubular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09928",
    "question": "What is associated with Total anomalous pulmonary venous return 1?",
    "seeds": [
      "Total anomalous pulmonary venous return 1"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09929",
    "question": "What is associated with Late infantile CLN2 disease?",
    "seeds": [
      "Late infantile CLN2 disease"
    ],
    "gold_answer": "TPP1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_09930",
    "question": "What is associated with Onychoheterotopia?",
    "seeds": [
      "Onychoheterotopia"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09931",
    "question": "What is associated with Pulverulent cataract?",
    "seeds": [
      "Pulverulent cataract"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09932",
    "question": "What is associated with Spinocerebellar ataxia 40?",
    "seeds": [
      "Spinocerebellar ataxia 40"
    ],
    "gold_answer": "Abnormal brainstem morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09933",
    "question": "What is associated with Distal tibial bowing?",
    "seeds": [
      "Distal tibial bowing"
    ],
    "gold_answer": "Abnormality of the ankle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09934",
    "question": "What phenotype is associated with Deafness, aminoglycoside-induced?",
    "seeds": [
      "Deafness, aminoglycoside-induced"
    ],
    "gold_answer": "Aminoglycoside-induced hearing loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09935",
    "question": "What is associated with Tracheal cartilaginous sleeve?",
    "seeds": [
      "Tracheal cartilaginous sleeve"
    ],
    "gold_answer": "Anomalous tracheal cartilage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09936",
    "question": "What is associated with Mitochondrial neurogastrointestinal encephalomyopathy?",
    "seeds": [
      "Mitochondrial neurogastrointestinal encephalomyopathy"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09937",
    "question": "What is associated with Triggered by fructose ingestion?",
    "seeds": [
      "Triggered by fructose ingestion"
    ],
    "gold_answer": "Triggered by carbohydrate ingestion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09938",
    "question": "What is associated with Generalized opacification of the cornea?",
    "seeds": [
      "Generalized opacification of the cornea"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09939",
    "question": "What is associated with Ovarian dysgenesis 4?",
    "seeds": [
      "Ovarian dysgenesis 4"
    ],
    "gold_answer": "Abnormal serum estradiol",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09940",
    "question": "What is associated with Pulmonary pseudocavity?",
    "seeds": [
      "Pulmonary pseudocavity"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09941",
    "question": "What is associated with Distal lower limb muscle weakness?",
    "seeds": [
      "Distal lower limb muscle weakness"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09942",
    "question": "What is associated with Fractured manual digit?",
    "seeds": [
      "Fractured manual digit"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09943",
    "question": "What is associated with Fragmentation of the epiphyses of the middle phalanges of the hand?",
    "seeds": [
      "Fragmentation of the epiphyses of the middle phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09944",
    "question": "What is associated with Argininosuccinic aciduria?",
    "seeds": [
      "Argininosuccinic aciduria"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09945",
    "question": "What is associated with Bleeding requiring red cell transfusion?",
    "seeds": [
      "Bleeding requiring red cell transfusion"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09946",
    "question": "What is associated with Feeding difficulties?",
    "seeds": [
      "Feeding difficulties"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09947",
    "question": "What is associated with Abnormal left ventricular function?",
    "seeds": [
      "Abnormal left ventricular function"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09948",
    "question": "What phenotype is associated with Abruzzo-Erickson syndrome?",
    "seeds": [
      "Abruzzo-Erickson syndrome"
    ],
    "gold_answer": "Toe syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09949",
    "question": "What is associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction?",
    "seeds": [
      "Hirschsprung disease, cardiac defects, and autonomic dysfunction"
    ],
    "gold_answer": "Abnormal enteric ganglion morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09950",
    "question": "What is associated with Ribbonlike corneal degeneration?",
    "seeds": [
      "Ribbonlike corneal degeneration"
    ],
    "gold_answer": "Corneal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09951",
    "question": "What phenotype is associated with Febrile seizures, familial, 1?",
    "seeds": [
      "Febrile seizures, familial, 1"
    ],
    "gold_answer": "Febrile seizure (within the age range of 3 months to 6 years)",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09952",
    "question": "What is associated with Herpes simplex virus stromal keratitis?",
    "seeds": [
      "Herpes simplex virus stromal keratitis"
    ],
    "gold_answer": "Abnormal corneal endothelium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09953",
    "question": "What is associated with Tubulointerstitial bacterial infiltration?",
    "seeds": [
      "Tubulointerstitial bacterial infiltration"
    ],
    "gold_answer": "Abnormal renal interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09954",
    "question": "What is associated with Elevated circulating D-glyceric acid concentration?",
    "seeds": [
      "Elevated circulating D-glyceric acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09955",
    "question": "What is associated with Abnormal muscle fiber dystrophin expression?",
    "seeds": [
      "Abnormal muscle fiber dystrophin expression"
    ],
    "gold_answer": "Abnormal muscle fiber protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09956",
    "question": "What is associated with Urinary hesitancy?",
    "seeds": [
      "Urinary hesitancy"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09957",
    "question": "What is associated with Inflammatory poikiloderma with hair abnormalities and acral keratoses?",
    "seeds": [
      "Inflammatory poikiloderma with hair abnormalities and acral keratoses"
    ],
    "gold_answer": "Sparse hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09958",
    "question": "What is associated with Acromicria?",
    "seeds": [
      "Acromicria"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09959",
    "question": "What is associated with Occupational silver exposure?",
    "seeds": [
      "Occupational silver exposure"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09960",
    "question": "What phenotype is associated with Immunodeficiency, common variable, 7?",
    "seeds": [
      "Immunodeficiency, common variable, 7"
    ],
    "gold_answer": "Chronic (near) absent circulating IgG4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09961",
    "question": "What is associated with Hyperpigmented/hypopigmented macules?",
    "seeds": [
      "Hyperpigmented/hypopigmented macules"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09962",
    "question": "What is associated with Spherocytosis, autosomal recessive?",
    "seeds": [
      "Spherocytosis, autosomal recessive"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09963",
    "question": "What phenotype is associated with IVIC syndrome?",
    "seeds": [
      "IVIC syndrome"
    ],
    "gold_answer": "Aplastic clavicles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09964",
    "question": "What is associated with Hypotrichosis-Lymphedema-Telangiectasia-Renal defect syndrome?",
    "seeds": [
      "Hypotrichosis-Lymphedema-Telangiectasia-Renal defect syndrome"
    ],
    "gold_answer": "Abnormal adipose tissue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09965",
    "question": "What is associated with Iris hypoperfusion?",
    "seeds": [
      "Iris hypoperfusion"
    ],
    "gold_answer": "Abnormal iris vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09966",
    "question": "What is associated with Short uvula?",
    "seeds": [
      "Short uvula"
    ],
    "gold_answer": "Abnormal soft palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09967",
    "question": "What is associated with Aortic arch calcification?",
    "seeds": [
      "Aortic arch calcification"
    ],
    "gold_answer": "Arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09968",
    "question": "What is associated with Intraluminal meconium calcification?",
    "seeds": [
      "Intraluminal meconium calcification"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09969",
    "question": "What is associated with Complement factor H deficiency?",
    "seeds": [
      "Complement factor H deficiency"
    ],
    "gold_answer": "Reduced circulating complement concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09970",
    "question": "What is associated with Abnormal 5th metacarpal morphology?",
    "seeds": [
      "Abnormal 5th metacarpal morphology"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09971",
    "question": "What is associated with Abnormal fallopian tube morphology?",
    "seeds": [
      "Abnormal fallopian tube morphology"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09972",
    "question": "What is associated with Spinocerebellar ataxia, X-linked 2?",
    "seeds": [
      "Spinocerebellar ataxia, X-linked 2"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09973",
    "question": "What is associated with Monomelic amyotrophy?",
    "seeds": [
      "Monomelic amyotrophy"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09974",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 37?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 37"
    ],
    "gold_answer": "Diminished movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09975",
    "question": "What is associated with Cardiac lipoma?",
    "seeds": [
      "Cardiac lipoma"
    ],
    "gold_answer": "Lipoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09976",
    "question": "What phenotype is associated with Hyperlipoproteinemia, type ID?",
    "seeds": [
      "Hyperlipoproteinemia, type ID"
    ],
    "gold_answer": "Hypertriglyceridemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09977",
    "question": "What is associated with Discoid adrenal gland?",
    "seeds": [
      "Discoid adrenal gland"
    ],
    "gold_answer": "Abnormal endocrine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09978",
    "question": "What is associated with Failure to thrive?",
    "seeds": [
      "Failure to thrive"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09979",
    "question": "What is associated with Diabetes mellitus, insulin-resistant, with acanthosis nigricans?",
    "seeds": [
      "Diabetes mellitus, insulin-resistant, with acanthosis nigricans"
    ],
    "gold_answer": "Hyperglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09980",
    "question": "What is associated with Dentin dysplasia, type II?",
    "seeds": [
      "Dentin dysplasia, type II"
    ],
    "gold_answer": "Abnormal dental pulp morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09981",
    "question": "What is associated with Broad proximal phalanx of toe?",
    "seeds": [
      "Broad proximal phalanx of toe"
    ],
    "gold_answer": "Abnormality of toe proximal phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09982",
    "question": "What is associated with Resistance to activated protein C?",
    "seeds": [
      "Resistance to activated protein C"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09983",
    "question": "What is associated with Agenesis of second permanent molar?",
    "seeds": [
      "Agenesis of second permanent molar"
    ],
    "gold_answer": "Selective tooth agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09984",
    "question": "What is associated with Abnormality of the genitourinary system?",
    "seeds": [
      "Abnormality of the genitourinary system"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09985",
    "question": "What phenotype is associated with Juvenile polyposis of infancy?",
    "seeds": [
      "Juvenile polyposis of infancy"
    ],
    "gold_answer": "Mandibular pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09986",
    "question": "What is associated with Positive blood 1,3 beta glucan test?",
    "seeds": [
      "Positive blood 1,3 beta glucan test"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09987",
    "question": "What is associated with Ichthyosis, hystrix-like, with deafness?",
    "seeds": [
      "Ichthyosis, hystrix-like, with deafness"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09988",
    "question": "What is associated with Kabuki syndrome?",
    "seeds": [
      "Kabuki syndrome"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09989",
    "question": "What is associated with Elevated urinary indican level?",
    "seeds": [
      "Elevated urinary indican level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09990",
    "question": "What is associated with Sporadic infantile bilateral striatal necrosis?",
    "seeds": [
      "Sporadic infantile bilateral striatal necrosis"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09991",
    "question": "What is associated with Hemimacroglossia?",
    "seeds": [
      "Hemimacroglossia"
    ],
    "gold_answer": "Macroglossia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09992",
    "question": "What phenotype is associated with DOORS syndrome?",
    "seeds": [
      "DOORS syndrome"
    ],
    "gold_answer": "Widely spaced teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_09993",
    "question": "What is associated with Decreased thyroid-stimulating hormone level?",
    "seeds": [
      "Decreased thyroid-stimulating hormone level"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09994",
    "question": "What is associated with Absence of labia majora?",
    "seeds": [
      "Absence of labia majora"
    ],
    "gold_answer": "Abnormal labia majora morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09995",
    "question": "What is associated with Elbow flexion contracture?",
    "seeds": [
      "Elbow flexion contracture"
    ],
    "gold_answer": "Abnormality of the elbow",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09996",
    "question": "What is associated with Prolonged bleeding after surgery?",
    "seeds": [
      "Prolonged bleeding after surgery"
    ],
    "gold_answer": "Prolonged bleeding following procedure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09997",
    "question": "What is associated with Deep episcleral hyperemia?",
    "seeds": [
      "Deep episcleral hyperemia"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09998",
    "question": "What is associated with Fetal narcotic exposure?",
    "seeds": [
      "Fetal narcotic exposure"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_09999",
    "question": "What is associated with Acromelic frontonasal dysplasia?",
    "seeds": [
      "Acromelic frontonasal dysplasia"
    ],
    "gold_answer": "Intracranial cystic lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10000",
    "question": "What is associated with Cardiac valvular dysplasia 2?",
    "seeds": [
      "Cardiac valvular dysplasia 2"
    ],
    "gold_answer": "Cyanosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10001",
    "question": "What is associated with Irregular epiphysis of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Irregular epiphysis of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10002",
    "question": "What phenotype is associated with Rhizomelic chondrodysplasia punctata, type 3?",
    "seeds": [
      "Rhizomelic chondrodysplasia punctata, type 3"
    ],
    "gold_answer": "Epiphyseal stippling",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10003",
    "question": "What is associated with Anti-integrin antibody positivity?",
    "seeds": [
      "Anti-integrin antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10004",
    "question": "What phenotype is associated with Amyotrophic lateral sclerosis 22 with or without frontotemporal dementia?",
    "seeds": [
      "Amyotrophic lateral sclerosis 22 with or without frontotemporal dementia"
    ],
    "gold_answer": "Frontotemporal dementia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10005",
    "question": "What is associated with Intention tremor?",
    "seeds": [
      "Intention tremor"
    ],
    "gold_answer": "Kinetic tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10006",
    "question": "What phenotype is associated with Hyperproinsulinemia?",
    "seeds": [
      "Hyperproinsulinemia"
    ],
    "gold_answer": "Hyperinsulinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10007",
    "question": "What phenotype is associated with Scott syndrome?",
    "seeds": [
      "Scott syndrome"
    ],
    "gold_answer": "Prolonged bleeding after surgery",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10008",
    "question": "What is associated with Hypersarcosinuria?",
    "seeds": [
      "Hypersarcosinuria"
    ],
    "gold_answer": "Increased proteinogenic amino acid level in urine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10009",
    "question": "What is associated with Conjunctival lipoma?",
    "seeds": [
      "Conjunctival lipoma"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10010",
    "question": "What is associated with Sonographic renal salt and pepper pattern?",
    "seeds": [
      "Sonographic renal salt and pepper pattern"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10011",
    "question": "What is associated with Ovarian dysgenesis 2?",
    "seeds": [
      "Ovarian dysgenesis 2"
    ],
    "gold_answer": "Hypogonadism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10012",
    "question": "What phenotype is associated with Bardet-Biedl syndrome 18?",
    "seeds": [
      "Bardet-Biedl syndrome 18"
    ],
    "gold_answer": "Rod-cone dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10013",
    "question": "What is associated with Amelogenesis imperfecta, type IA?",
    "seeds": [
      "Amelogenesis imperfecta, type IA"
    ],
    "gold_answer": "Abnormal dental morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10014",
    "question": "What phenotype is associated with Welander distal myopathy?",
    "seeds": [
      "Welander distal myopathy"
    ],
    "gold_answer": "Mildly elevated creatine kinase",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10015",
    "question": "What phenotype is associated with Myopathy, X-linked, with postural muscle atrophy?",
    "seeds": [
      "Myopathy, X-linked, with postural muscle atrophy"
    ],
    "gold_answer": "Short neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10016",
    "question": "What is associated with Penile swelling?",
    "seeds": [
      "Penile swelling"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10017",
    "question": "What is associated with Hypermobility of distal interphalangeal joints?",
    "seeds": [
      "Hypermobility of distal interphalangeal joints"
    ],
    "gold_answer": "Hypermobility of interphalangeal joints",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10018",
    "question": "What phenotype is associated with Autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)?",
    "seeds": [
      "Autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)"
    ],
    "gold_answer": "Diffuse demyelination of the cerebral white matter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10019",
    "question": "What is associated with Exercise-induced malignant hyperthermia?",
    "seeds": [
      "Exercise-induced malignant hyperthermia"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10020",
    "question": "What is associated with Fatigable weakness?",
    "seeds": [
      "Fatigable weakness"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10021",
    "question": "What is associated with Decreased T cell apoptosis?",
    "seeds": [
      "Decreased T cell apoptosis"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10022",
    "question": "What is associated with Hypotrichosis 15?",
    "seeds": [
      "Hypotrichosis 15"
    ],
    "gold_answer": "Sparse hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10023",
    "question": "What is associated with Reduced CD95-induced lymphocyte apoptosis?",
    "seeds": [
      "Reduced CD95-induced lymphocyte apoptosis"
    ],
    "gold_answer": "Decreased T cell apoptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10024",
    "question": "What is associated with Cervical vertebral bodies with decreased anteroposterior diameter?",
    "seeds": [
      "Cervical vertebral bodies with decreased anteroposterior diameter"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10025",
    "question": "What is associated with Hyporeflective spaces on macular OCT?",
    "seeds": [
      "Hyporeflective spaces on macular OCT"
    ],
    "gold_answer": "Abnormal retinal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10026",
    "question": "What is associated with Asynergia?",
    "seeds": [
      "Asynergia"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10027",
    "question": "What is associated with Contracture of the proximal interphalangeal joint of the 4th finger?",
    "seeds": [
      "Contracture of the proximal interphalangeal joint of the 4th finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10028",
    "question": "What is associated with Increased circulating creatine kinase MM isoform?",
    "seeds": [
      "Increased circulating creatine kinase MM isoform"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10029",
    "question": "What is associated with Fungal meningitis?",
    "seeds": [
      "Fungal meningitis"
    ],
    "gold_answer": "Meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10030",
    "question": "What phenotype is associated with Migraine with or without aura, susceptibility to, 3?",
    "seeds": [
      "Migraine with or without aura, susceptibility to, 3"
    ],
    "gold_answer": "Phonophobia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10031",
    "question": "What is associated with Increased CSF aspartate concentration?",
    "seeds": [
      "Increased CSF aspartate concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10032",
    "question": "What is associated with Hypoganglionosis?",
    "seeds": [
      "Hypoganglionosis"
    ],
    "gold_answer": "Abnormal enteric ganglion morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10033",
    "question": "What is associated with Pectus carinatum?",
    "seeds": [
      "Pectus carinatum"
    ],
    "gold_answer": "Abnormal sternum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10034",
    "question": "What is associated with Chronic fatigue?",
    "seeds": [
      "Chronic fatigue"
    ],
    "gold_answer": "Fatigue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10035",
    "question": "What is associated with Heinz body anemia?",
    "seeds": [
      "Heinz body anemia"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10036",
    "question": "What is associated with Early chronotype?",
    "seeds": [
      "Early chronotype"
    ],
    "gold_answer": "Sleep-wake cycle disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10037",
    "question": "What is associated with Poor gross motor coordination?",
    "seeds": [
      "Poor gross motor coordination"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10038",
    "question": "What is associated with Pulmonary pseudocavity?",
    "seeds": [
      "Pulmonary pseudocavity"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10039",
    "question": "What is associated with Hypoplastic fifth toenail?",
    "seeds": [
      "Hypoplastic fifth toenail"
    ],
    "gold_answer": "Abnormal toenail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10040",
    "question": "What is associated with Cowden syndrome 6?",
    "seeds": [
      "Cowden syndrome 6"
    ],
    "gold_answer": "Neoplasm of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10041",
    "question": "What is associated with Spastic paraplegia 53, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 53, autosomal recessive"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10042",
    "question": "What is associated with Primary condylar hyperplasia?",
    "seeds": [
      "Primary condylar hyperplasia"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10043",
    "question": "What is associated with Renal lymphocytic tubulitis?",
    "seeds": [
      "Renal lymphocytic tubulitis"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10044",
    "question": "What is associated with Fatigable weakness of speech muscles?",
    "seeds": [
      "Fatigable weakness of speech muscles"
    ],
    "gold_answer": "Fatigable weakness of bulbar muscles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10045",
    "question": "What is associated with Hyperuricemic nephropathy, familial juvenile, 2?",
    "seeds": [
      "Hyperuricemic nephropathy, familial juvenile, 2"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10046",
    "question": "What is associated with Recurrent interdigital mycosis?",
    "seeds": [
      "Recurrent interdigital mycosis"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10047",
    "question": "What is associated with Diffuse cerebral calcification?",
    "seeds": [
      "Diffuse cerebral calcification"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10048",
    "question": "What is associated with Distal renal tubular acidosis?",
    "seeds": [
      "Distal renal tubular acidosis"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10049",
    "question": "What is associated with Acrosomal hypoplasia?",
    "seeds": [
      "Acrosomal hypoplasia"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10050",
    "question": "What is associated with Severe acute respiratory syndrome?",
    "seeds": [
      "Severe acute respiratory syndrome"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10051",
    "question": "What is associated with High renal tubular epithelial cell N/C ratio?",
    "seeds": [
      "High renal tubular epithelial cell N/C ratio"
    ],
    "gold_answer": "Abnormal renal tubular epithelial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10052",
    "question": "What phenotype is associated with Congenital primary aphakia?",
    "seeds": [
      "Congenital primary aphakia"
    ],
    "gold_answer": "Chorioretinal hypopigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10053",
    "question": "What is associated with Nuchal cord?",
    "seeds": [
      "Nuchal cord"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10054",
    "question": "What is associated with Laryngeal carcinoma?",
    "seeds": [
      "Laryngeal carcinoma"
    ],
    "gold_answer": "Neoplasm of the larynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10055",
    "question": "What is associated with Spiral fracture?",
    "seeds": [
      "Spiral fracture"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10056",
    "question": "What is associated with Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome?",
    "seeds": [
      "Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10057",
    "question": "What is associated with 1-4 finger cutaneous syndactyly?",
    "seeds": [
      "1-4 finger cutaneous syndactyly"
    ],
    "gold_answer": "Finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10058",
    "question": "What is associated with Abnormal lung lobation?",
    "seeds": [
      "Abnormal lung lobation"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10059",
    "question": "What is associated with Increased urinary multiantennary sialylated oligosaccharide?",
    "seeds": [
      "Increased urinary multiantennary sialylated oligosaccharide"
    ],
    "gold_answer": "Abnormal urine carbohydrate level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10060",
    "question": "What phenotype is associated with Isolated thyroid-stimulating hormone deficiency?",
    "seeds": [
      "Isolated thyroid-stimulating hormone deficiency"
    ],
    "gold_answer": "Delayed proximal femoral epiphyseal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10061",
    "question": "What is associated with Sloping ulnar metaphysis?",
    "seeds": [
      "Sloping ulnar metaphysis"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10062",
    "question": "What is associated with Anonychia-microcephaly syndrome?",
    "seeds": [
      "Anonychia-microcephaly syndrome"
    ],
    "gold_answer": "Single transverse palmar crease",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10063",
    "question": "What is associated with Abnormality of the proximal humeral epiphysis?",
    "seeds": [
      "Abnormality of the proximal humeral epiphysis"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10064",
    "question": "What is associated with First dorsal interossei muscle atrophy?",
    "seeds": [
      "First dorsal interossei muscle atrophy"
    ],
    "gold_answer": "Interosseus muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10065",
    "question": "What is associated with Abnormal circulating properdin level?",
    "seeds": [
      "Abnormal circulating properdin level"
    ],
    "gold_answer": "Abnormal circulating beta globulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10066",
    "question": "What is associated with Xeroderma pigmentosum, complementation group F?",
    "seeds": [
      "Xeroderma pigmentosum, complementation group F"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10067",
    "question": "What phenotype is associated with Panencephalitis, subacute sclerosing?",
    "seeds": [
      "Panencephalitis, subacute sclerosing"
    ],
    "gold_answer": "Infectious encephalitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10068",
    "question": "What is associated with Localized to the lower eyelid?",
    "seeds": [
      "Localized to the lower eyelid"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10069",
    "question": "What is associated with Focal impaired awareness cognitive seizure with forced thinking?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with forced thinking"
    ],
    "gold_answer": "Psychic epileptic aura",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10070",
    "question": "What is associated with Pancreatic lymphangiectasis?",
    "seeds": [
      "Pancreatic lymphangiectasis"
    ],
    "gold_answer": "Lymphangiectasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10071",
    "question": "What is associated with Positive gastric CMV intranuclear inclusions?",
    "seeds": [
      "Positive gastric CMV intranuclear inclusions"
    ],
    "gold_answer": "Pathological inclusion body by subcellular location",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10072",
    "question": "What is associated with Diminished urine glutamine level?",
    "seeds": [
      "Diminished urine glutamine level"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10073",
    "question": "What is associated with Deafness, autosomal recessive 108?",
    "seeds": [
      "Deafness, autosomal recessive 108"
    ],
    "gold_answer": "Coloboma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10074",
    "question": "What phenotype is associated with Neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities"
    ],
    "gold_answer": "High palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10075",
    "question": "What is associated with Abnormality of the gastrointestinal tract?",
    "seeds": [
      "Abnormality of the gastrointestinal tract"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10076",
    "question": "What is associated with Glycosylphosphatidylinositol biosynthesis defect 18?",
    "seeds": [
      "Glycosylphosphatidylinositol biosynthesis defect 18"
    ],
    "gold_answer": "Hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10077",
    "question": "What phenotype is associated with Lymphoproliferative syndrome 3?",
    "seeds": [
      "Lymphoproliferative syndrome 3"
    ],
    "gold_answer": "Severe varicella zoster infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10078",
    "question": "What is associated with Post-partum hemorrhage?",
    "seeds": [
      "Post-partum hemorrhage"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10079",
    "question": "What is associated with Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency?",
    "seeds": [
      "Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10080",
    "question": "What is associated with Decreased CSF valine concentration?",
    "seeds": [
      "Decreased CSF valine concentration"
    ],
    "gold_answer": "Abnormal CSF valine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10081",
    "question": "What is associated with Focal impaired awareness epileptic spasm?",
    "seeds": [
      "Focal impaired awareness epileptic spasm"
    ],
    "gold_answer": "Focal-onset epileptic spasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10082",
    "question": "What is associated with Abnormal small intestinal mucosa morphology?",
    "seeds": [
      "Abnormal small intestinal mucosa morphology"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10083",
    "question": "What is associated with Moderate multiminicore disease with hand involvement?",
    "seeds": [
      "Moderate multiminicore disease with hand involvement"
    ],
    "gold_answer": "Abnormality of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10084",
    "question": "What is associated with Type 1 and type 2 muscle fiber minicore regions?",
    "seeds": [
      "Type 1 and type 2 muscle fiber minicore regions"
    ],
    "gold_answer": "Minicore myopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10085",
    "question": "What is associated with Apical muscular ventricular septal defect?",
    "seeds": [
      "Apical muscular ventricular septal defect"
    ],
    "gold_answer": "Abnormal ventricular septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10086",
    "question": "What is associated with Thistle tube shaped pulp?",
    "seeds": [
      "Thistle tube shaped pulp"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10087",
    "question": "What is associated with Decreased skin turgor?",
    "seeds": [
      "Decreased skin turgor"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10088",
    "question": "What is associated with Hypotrichosis 13?",
    "seeds": [
      "Hypotrichosis 13"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10089",
    "question": "What is associated with Basal ganglia gliosis?",
    "seeds": [
      "Basal ganglia gliosis"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10090",
    "question": "What is associated with Left ventricular outflow tract obstruction?",
    "seeds": [
      "Left ventricular outflow tract obstruction"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10091",
    "question": "What is associated with Seizures, benign familial infantile, 2?",
    "seeds": [
      "Seizures, benign familial infantile, 2"
    ],
    "gold_answer": "Infection-related seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10092",
    "question": "What is associated with Endometrial carcinoma?",
    "seeds": [
      "Endometrial carcinoma"
    ],
    "gold_answer": "Genital neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10093",
    "question": "What is associated with Pseudoepiphysis of the distal phalanx of the 5th toe?",
    "seeds": [
      "Pseudoepiphysis of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Pseudoepiphyses of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10094",
    "question": "What is associated with Small thumb epiphysis?",
    "seeds": [
      "Small thumb epiphysis"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10095",
    "question": "What is associated with Increased pulmonary capillary wedge pressure?",
    "seeds": [
      "Increased pulmonary capillary wedge pressure"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10096",
    "question": "What is associated with Nasopharyngeal carcinoma, susceptibility to, 2?",
    "seeds": [
      "Nasopharyngeal carcinoma, susceptibility to, 2"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10097",
    "question": "What is associated with Cor triatriatum sinister?",
    "seeds": [
      "Cor triatriatum sinister"
    ],
    "gold_answer": "Abnormal cardiac atrium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10098",
    "question": "What is associated with Anterior wedging of T12?",
    "seeds": [
      "Anterior wedging of T12"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10099",
    "question": "What is associated with Intellectual developmental disorder with cardiac arrhythmia?",
    "seeds": [
      "Intellectual developmental disorder with cardiac arrhythmia"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10100",
    "question": "What is associated with Triggered by head trauma?",
    "seeds": [
      "Triggered by head trauma"
    ],
    "gold_answer": "Triggered by physical trauma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10101",
    "question": "What is associated with Spastic paralysis, infantile-onset ascending?",
    "seeds": [
      "Spastic paralysis, infantile-onset ascending"
    ],
    "gold_answer": "Abnormal peripheral nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10102",
    "question": "What phenotype is associated with Hereditary hyperferritinemia-cataract syndrome?",
    "seeds": [
      "Hereditary hyperferritinemia-cataract syndrome"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10103",
    "question": "What is associated with Calcium channel antibody positivity?",
    "seeds": [
      "Calcium channel antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10104",
    "question": "What is associated with Bracket epiphyses of the middle phalanges of the hand?",
    "seeds": [
      "Bracket epiphyses of the middle phalanges of the hand"
    ],
    "gold_answer": "Abnormal hand epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10105",
    "question": "What is associated with Abnormal circulating hormone concentration?",
    "seeds": [
      "Abnormal circulating hormone concentration"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10106",
    "question": "What is associated with Abnormal cochlea morphology?",
    "seeds": [
      "Abnormal cochlea morphology"
    ],
    "gold_answer": "Abnormal inner ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10107",
    "question": "What is associated with Axial?",
    "seeds": [
      "Axial"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10108",
    "question": "What is associated with Sneddon syndrome?",
    "seeds": [
      "Sneddon syndrome"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10109",
    "question": "What is associated with Histiocytosis-lymphadenopathy plus syndrome?",
    "seeds": [
      "Histiocytosis-lymphadenopathy plus syndrome"
    ],
    "gold_answer": "Hypoplasia of penis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10110",
    "question": "What is associated with Supernumerary nostril?",
    "seeds": [
      "Supernumerary nostril"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10111",
    "question": "What is associated with Autoimmune hemolytic anemia?",
    "seeds": [
      "Autoimmune hemolytic anemia"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10112",
    "question": "What is associated with Esophageal diverticulum?",
    "seeds": [
      "Esophageal diverticulum"
    ],
    "gold_answer": "Abnormal esophagus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10113",
    "question": "What is associated with Excessively loud speech?",
    "seeds": [
      "Excessively loud speech"
    ],
    "gold_answer": "Abnormal speech volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10114",
    "question": "What is associated with Exstrophy?",
    "seeds": [
      "Exstrophy"
    ],
    "gold_answer": "Abnormal abdominal wall morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10115",
    "question": "What is associated with Keratinocyte vacuolization?",
    "seeds": [
      "Keratinocyte vacuolization"
    ],
    "gold_answer": "Abnormal epidermal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10116",
    "question": "What is associated with Acquired partial lipodystrophy?",
    "seeds": [
      "Acquired partial lipodystrophy"
    ],
    "gold_answer": "Prematurely aged appearance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10117",
    "question": "What is associated with Lymphangiectasis?",
    "seeds": [
      "Lymphangiectasis"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10118",
    "question": "What is associated with X-linked Charcot-Marie-Tooth disease type 2?",
    "seeds": [
      "X-linked Charcot-Marie-Tooth disease type 2"
    ],
    "gold_answer": "Abnormality of the musculature of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10119",
    "question": "What phenotype is associated with Spermatogenic failure 82?",
    "seeds": [
      "Spermatogenic failure 82"
    ],
    "gold_answer": "Short sperm flagella",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10120",
    "question": "What phenotype is associated with Hemolytic anemia, congenital, X-linked?",
    "seeds": [
      "Hemolytic anemia, congenital, X-linked"
    ],
    "gold_answer": "Hemolytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10121",
    "question": "What is associated with Abnormal fetal femur length?",
    "seeds": [
      "Abnormal fetal femur length"
    ],
    "gold_answer": "Abnormal fetal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10122",
    "question": "What is associated with Reduced glutathione synthetase level?",
    "seeds": [
      "Reduced glutathione synthetase level"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10123",
    "question": "What is associated with Elevated circulating glucosylsphingosine concentration?",
    "seeds": [
      "Elevated circulating glucosylsphingosine concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10124",
    "question": "What is associated with Rhizomelic chondrodysplasia punctata, type 5?",
    "seeds": [
      "Rhizomelic chondrodysplasia punctata, type 5"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10125",
    "question": "What is associated with Primary failure of tooth eruption?",
    "seeds": [
      "Primary failure of tooth eruption"
    ],
    "gold_answer": "PTH1R",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_10126",
    "question": "What phenotype is associated with Cole-Carpenter syndrome 2?",
    "seeds": [
      "Cole-Carpenter syndrome 2"
    ],
    "gold_answer": "Dentinogenesis imperfecta",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10127",
    "question": "What is associated with Hypotrichosis 2?",
    "seeds": [
      "Hypotrichosis 2"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10128",
    "question": "What is associated with Impaired Ig class switch recombination?",
    "seeds": [
      "Impaired Ig class switch recombination"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10129",
    "question": "What is associated with Short stature-deafness-neutrophil dysfunction-dysmorphism syndrome?",
    "seeds": [
      "Short stature-deafness-neutrophil dysfunction-dysmorphism syndrome"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10130",
    "question": "What is associated with Anti-PM-Scl100 antibody positivity?",
    "seeds": [
      "Anti-PM-Scl100 antibody positivity"
    ],
    "gold_answer": "Anti-PM-Scl antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10131",
    "question": "What is associated with Aplastic pubic bone?",
    "seeds": [
      "Aplastic pubic bone"
    ],
    "gold_answer": "Abnormal hip bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10132",
    "question": "What is associated with Anti-soluble liver antigen/liver pancreas antibody positivity?",
    "seeds": [
      "Anti-soluble liver antigen/liver pancreas antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10133",
    "question": "What is associated with Spastic paraplegia-glaucoma-intellectual disability syndrome?",
    "seeds": [
      "Spastic paraplegia-glaucoma-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10134",
    "question": "What is associated with Congenital onychodystrophy?",
    "seeds": [
      "Congenital onychodystrophy"
    ],
    "gold_answer": "Nail dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10135",
    "question": "What phenotype is associated with Skin creases, congenital symmetric circumferential, 2?",
    "seeds": [
      "Skin creases, congenital symmetric circumferential, 2"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10136",
    "question": "What is associated with Hypoplastic pubic ramus?",
    "seeds": [
      "Hypoplastic pubic ramus"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the pubic bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10137",
    "question": "What is associated with Oculocerebral hypopigmentation syndrome, Cross type?",
    "seeds": [
      "Oculocerebral hypopigmentation syndrome, Cross type"
    ],
    "gold_answer": "Macular thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10138",
    "question": "What is associated with RELA fusion-positive ependymoma?",
    "seeds": [
      "RELA fusion-positive ependymoma"
    ],
    "gold_answer": "RELA",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_10139",
    "question": "What is associated with Cardiomyopathy, dilated, 1H?",
    "seeds": [
      "Cardiomyopathy, dilated, 1H"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10140",
    "question": "What phenotype is associated with Facial clefting, oblique, 1?",
    "seeds": [
      "Facial clefting, oblique, 1"
    ],
    "gold_answer": "Talipes calcaneovalgus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10141",
    "question": "What is associated with Coronary arterial fistula?",
    "seeds": [
      "Coronary arterial fistula"
    ],
    "gold_answer": "Abnormal atrial septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10142",
    "question": "What is associated with Infantile onset?",
    "seeds": [
      "Infantile onset"
    ],
    "gold_answer": "Pediatric onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10143",
    "question": "What is associated with Fibromatosis, gingival, 1?",
    "seeds": [
      "Fibromatosis, gingival, 1"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10144",
    "question": "What is associated with Disturbance of facial expression?",
    "seeds": [
      "Disturbance of facial expression"
    ],
    "gold_answer": "Abnormal facial expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10145",
    "question": "What is associated with Estrogen resistance?",
    "seeds": [
      "Estrogen resistance"
    ],
    "gold_answer": "Elevated tissue non-specific alkaline phosphatase",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10146",
    "question": "What is associated with Glutamine deficiency, congenital?",
    "seeds": [
      "Glutamine deficiency, congenital"
    ],
    "gold_answer": "Limb undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10147",
    "question": "What is associated with ACCES syndrome?",
    "seeds": [
      "ACCES syndrome"
    ],
    "gold_answer": "BMS1",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10148",
    "question": "What is associated with Aplasia/hypoplasia of the humerus?",
    "seeds": [
      "Aplasia/hypoplasia of the humerus"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10149",
    "question": "What phenotype is associated with Situs inversus totalis?",
    "seeds": [
      "Situs inversus totalis"
    ],
    "gold_answer": "Neuroblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10150",
    "question": "What is associated with Red skin pigment anomaly of new guinea?",
    "seeds": [
      "Red skin pigment anomaly of new guinea"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10151",
    "question": "What is associated with Focal aware cognitive seizure with receptive dysphasia/aphasia?",
    "seeds": [
      "Focal aware cognitive seizure with receptive dysphasia/aphasia"
    ],
    "gold_answer": "Focal aware seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10152",
    "question": "What is associated with Micronodular cirrhosis?",
    "seeds": [
      "Micronodular cirrhosis"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10153",
    "question": "What is associated with Salty tasting skin?",
    "seeds": [
      "Salty tasting skin"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10154",
    "question": "What is associated with Isolated cerebellar agenesis?",
    "seeds": [
      "Isolated cerebellar agenesis"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10155",
    "question": "What is associated with Carnitinuria?",
    "seeds": [
      "Carnitinuria"
    ],
    "gold_answer": "Abnormal urine carboxylic acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10156",
    "question": "What phenotype is associated with Macdermot-Winter syndrome?",
    "seeds": [
      "Macdermot-Winter syndrome"
    ],
    "gold_answer": "Wide intermamillary distance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10157",
    "question": "What is associated with Osteopenia-intellectual disability-sparse hair syndrome?",
    "seeds": [
      "Osteopenia-intellectual disability-sparse hair syndrome"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10158",
    "question": "What is associated with Increased density of long bone diaphyses?",
    "seeds": [
      "Increased density of long bone diaphyses"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10159",
    "question": "What is associated with Broad 5th toe?",
    "seeds": [
      "Broad 5th toe"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10160",
    "question": "What is associated with Oligodontia?",
    "seeds": [
      "Oligodontia"
    ],
    "gold_answer": "Abnormal dental pulp morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10161",
    "question": "What is associated with Exacerbated by amiodarone exposure?",
    "seeds": [
      "Exacerbated by amiodarone exposure"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10162",
    "question": "What is associated with Increased vertical cup-to-disc ratio?",
    "seeds": [
      "Increased vertical cup-to-disc ratio"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10163",
    "question": "What phenotype is associated with Cardiofaciocutaneous syndrome 1?",
    "seeds": [
      "Cardiofaciocutaneous syndrome 1"
    ],
    "gold_answer": "Gastroesophageal reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10164",
    "question": "What is associated with Reduced social reciprocity?",
    "seeds": [
      "Reduced social reciprocity"
    ],
    "gold_answer": "Abnormal social development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10165",
    "question": "What is associated with Craniofacial dysostosis-diaphyseal hyperplasia syndrome?",
    "seeds": [
      "Craniofacial dysostosis-diaphyseal hyperplasia syndrome"
    ],
    "gold_answer": "Limb undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10166",
    "question": "What is associated with Abnormal alpha granule distribution?",
    "seeds": [
      "Abnormal alpha granule distribution"
    ],
    "gold_answer": "Abnormal platelet morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10167",
    "question": "What is associated with Cone-Rod dystrophy, X-linked, 2?",
    "seeds": [
      "Cone-Rod dystrophy, X-linked, 2"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10168",
    "question": "What is associated with Secondary Caesarian section?",
    "seeds": [
      "Secondary Caesarian section"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10169",
    "question": "What is associated with Drusen?",
    "seeds": [
      "Drusen"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10170",
    "question": "What is associated with Absence of labia majora?",
    "seeds": [
      "Absence of labia majora"
    ],
    "gold_answer": "Abnormal labia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10171",
    "question": "What is associated with Decreased sensory nerve conduction velocity?",
    "seeds": [
      "Decreased sensory nerve conduction velocity"
    ],
    "gold_answer": "Decreased nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10172",
    "question": "What is associated with Dysmetric vertical saccades?",
    "seeds": [
      "Dysmetric vertical saccades"
    ],
    "gold_answer": "Dysmetric saccades",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10173",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 77?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 77"
    ],
    "gold_answer": "Unsteady gait",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10174",
    "question": "What is associated with Absent humeral epiphyseal ossification?",
    "seeds": [
      "Absent humeral epiphyseal ossification"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10175",
    "question": "What is associated with Elevated circulating sCD25 concentration?",
    "seeds": [
      "Elevated circulating sCD25 concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10176",
    "question": "What phenotype is associated with Obesity, susceptibility to, BMIQ14?",
    "seeds": [
      "Obesity, susceptibility to, BMIQ14"
    ],
    "gold_answer": "Obesity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10177",
    "question": "What is associated with Robinow syndrome, autosomal dominant 2?",
    "seeds": [
      "Robinow syndrome, autosomal dominant 2"
    ],
    "gold_answer": "Abnormal soft palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10178",
    "question": "What is associated with Fractured thumb phalanx?",
    "seeds": [
      "Fractured thumb phalanx"
    ],
    "gold_answer": "Fractured finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10179",
    "question": "What is associated with Abnormal reticulocyte morphology?",
    "seeds": [
      "Abnormal reticulocyte morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10180",
    "question": "What is associated with Xeroderma pigmentosum variant?",
    "seeds": [
      "Xeroderma pigmentosum variant"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10181",
    "question": "What is associated with Adult Refsum disease?",
    "seeds": [
      "Adult Refsum disease"
    ],
    "gold_answer": "Abnormal abdomen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10182",
    "question": "What is associated with Spermatogenic failure 58?",
    "seeds": [
      "Spermatogenic failure 58"
    ],
    "gold_answer": "Abnormal spermatogenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10183",
    "question": "What is associated with Fractured pisiform bone?",
    "seeds": [
      "Fractured pisiform bone"
    ],
    "gold_answer": "Fractured carpal bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10184",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy"
    ],
    "gold_answer": "Abnormal peripheral nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10185",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type IIl?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIl"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10186",
    "question": "What is associated with Aplasia of the phalanges of the 5th toe?",
    "seeds": [
      "Aplasia of the phalanges of the 5th toe"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10187",
    "question": "What is associated with Unicoronal synostosis?",
    "seeds": [
      "Unicoronal synostosis"
    ],
    "gold_answer": "Craniosynostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10188",
    "question": "What is associated with GLUCOGLYCINURIA?",
    "seeds": [
      "GLUCOGLYCINURIA"
    ],
    "gold_answer": "Increased proteinogenic amino acid level in urine",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10189",
    "question": "What is associated with Abnormality of globe location?",
    "seeds": [
      "Abnormality of globe location"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10190",
    "question": "What is associated with Idiopathic bilateral vestibulopathy?",
    "seeds": [
      "Idiopathic bilateral vestibulopathy"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10191",
    "question": "What is associated with Abnormality of the radial head?",
    "seeds": [
      "Abnormality of the radial head"
    ],
    "gold_answer": "Abnormal morphology of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10192",
    "question": "What is associated with Premature epimetaphyseal fusion in radius?",
    "seeds": [
      "Premature epimetaphyseal fusion in radius"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10193",
    "question": "What phenotype is associated with Spinal muscular atrophy, type II?",
    "seeds": [
      "Spinal muscular atrophy, type II"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10194",
    "question": "What is associated with Abnormal CSF dopamine concentration?",
    "seeds": [
      "Abnormal CSF dopamine concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10195",
    "question": "What phenotype is associated with Bronchiolitis obliterans?",
    "seeds": [
      "Bronchiolitis obliterans"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10196",
    "question": "What is associated with Grayish enamel?",
    "seeds": [
      "Grayish enamel"
    ],
    "gold_answer": "Abnormal dental enamel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10197",
    "question": "What is associated with Abnormal shoulder physiology?",
    "seeds": [
      "Abnormal shoulder physiology"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10198",
    "question": "What is associated with Chronic constipation?",
    "seeds": [
      "Chronic constipation"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10199",
    "question": "What is associated with Renal interstitial amyloid deposits?",
    "seeds": [
      "Renal interstitial amyloid deposits"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10200",
    "question": "What is associated with Abnormal ocular adnexa morphology?",
    "seeds": [
      "Abnormal ocular adnexa morphology"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10201",
    "question": "What is associated with Fragile X tremor/ataxia syndrome?",
    "seeds": [
      "Fragile X tremor/ataxia syndrome"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10202",
    "question": "What is associated with Myopia 22, autosomal dominant?",
    "seeds": [
      "Myopia 22, autosomal dominant"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10203",
    "question": "What is associated with Gait ataxia?",
    "seeds": [
      "Gait ataxia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10204",
    "question": "What is associated with Abnormal R wave?",
    "seeds": [
      "Abnormal R wave"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10205",
    "question": "What is associated with Fifth finger symphalangism?",
    "seeds": [
      "Fifth finger symphalangism"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10206",
    "question": "What is associated with Focal aware cognitive seizure with forced thinking?",
    "seeds": [
      "Focal aware cognitive seizure with forced thinking"
    ],
    "gold_answer": "Focal cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10207",
    "question": "What is associated with ALDH18A1-related De Barsy syndrome?",
    "seeds": [
      "ALDH18A1-related De Barsy syndrome"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10208",
    "question": "What is associated with Hypogonadotropic hypogonadism 27 without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 27 without anosmia"
    ],
    "gold_answer": "Decreased circulating gonadotropin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10209",
    "question": "What phenotype is associated with Polydactyly, preaxial III?",
    "seeds": [
      "Polydactyly, preaxial III"
    ],
    "gold_answer": "Triphalangeal thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10210",
    "question": "What is associated with Aniridia-renal agenesis-psychomotor retardation syndrome?",
    "seeds": [
      "Aniridia-renal agenesis-psychomotor retardation syndrome"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10211",
    "question": "What is associated with Facial paresis, hereditary congenital, 3?",
    "seeds": [
      "Facial paresis, hereditary congenital, 3"
    ],
    "gold_answer": "Abnormality of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10212",
    "question": "What phenotype is associated with Peroxisome biogenesis disorder 12A (Zellweger)?",
    "seeds": [
      "Peroxisome biogenesis disorder 12A (Zellweger)"
    ],
    "gold_answer": "Pseudocoarctation of the aorta",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10213",
    "question": "What is associated with Adenocarcinoma of the small intestine?",
    "seeds": [
      "Adenocarcinoma of the small intestine"
    ],
    "gold_answer": "Gastrointestinal carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10214",
    "question": "What is associated with Mycobacterium bacteremia?",
    "seeds": [
      "Mycobacterium bacteremia"
    ],
    "gold_answer": "Bloodstream infectious agent",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10215",
    "question": "What phenotype is associated with Kaposi sarcoma?",
    "seeds": [
      "Kaposi sarcoma"
    ],
    "gold_answer": "Skin nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10216",
    "question": "What phenotype is associated with Hirschsprung disease, susceptibility to, 4?",
    "seeds": [
      "Hirschsprung disease, susceptibility to, 4"
    ],
    "gold_answer": "Aganglionic megacolon",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10217",
    "question": "What is associated with Congenital bilateral ptosis?",
    "seeds": [
      "Congenital bilateral ptosis"
    ],
    "gold_answer": "Congenital ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10218",
    "question": "What is associated with Scapuloperoneal amyotrophy?",
    "seeds": [
      "Scapuloperoneal amyotrophy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10219",
    "question": "What is associated with Small humeral epiphyses?",
    "seeds": [
      "Small humeral epiphyses"
    ],
    "gold_answer": "Abnormal humeral epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10220",
    "question": "What is associated with Abnormal Humphrey SITA 10-2 perimetry test?",
    "seeds": [
      "Abnormal Humphrey SITA 10-2 perimetry test"
    ],
    "gold_answer": "Abnormal visual field test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10221",
    "question": "What is associated with Lethal congenital contracture syndrome 8?",
    "seeds": [
      "Lethal congenital contracture syndrome 8"
    ],
    "gold_answer": "Somatic sensory dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10222",
    "question": "What is associated with Tetraplegia/tetraparesis?",
    "seeds": [
      "Tetraplegia/tetraparesis"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10223",
    "question": "What is associated with Status post organ transplantation?",
    "seeds": [
      "Status post organ transplantation"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10224",
    "question": "What is associated with Abnormal urinary nitrogen compound level?",
    "seeds": [
      "Abnormal urinary nitrogen compound level"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10225",
    "question": "What is associated with Anti-GlyR antibody?",
    "seeds": [
      "Anti-GlyR antibody"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10226",
    "question": "What is associated with Episodic paroxysmal anxiety?",
    "seeds": [
      "Episodic paroxysmal anxiety"
    ],
    "gold_answer": "Anxiety",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10227",
    "question": "What is associated with Ventral shortening of foreskin?",
    "seeds": [
      "Ventral shortening of foreskin"
    ],
    "gold_answer": "Abnormal preputium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10228",
    "question": "What phenotype is associated with Vitreoretinopathy, neovascular inflammatory?",
    "seeds": [
      "Vitreoretinopathy, neovascular inflammatory"
    ],
    "gold_answer": "Vitreoretinopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10229",
    "question": "What is associated with Pseudohypoparathyroidism?",
    "seeds": [
      "Pseudohypoparathyroidism"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10230",
    "question": "What is associated with Lethal acantholytic erosive disorder?",
    "seeds": [
      "Lethal acantholytic erosive disorder"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10231",
    "question": "What is associated with Microvillus inclusion disease?",
    "seeds": [
      "Microvillus inclusion disease"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10232",
    "question": "What is associated with Diabetes mellitus, permanent neonatal 4?",
    "seeds": [
      "Diabetes mellitus, permanent neonatal 4"
    ],
    "gold_answer": "Diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10233",
    "question": "What phenotype is associated with Sveinsson chorioretinal atrophy?",
    "seeds": [
      "Sveinsson chorioretinal atrophy"
    ],
    "gold_answer": "Astigmatism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10234",
    "question": "What is associated with Microcephalic primordial dwarfism, Montreal type?",
    "seeds": [
      "Microcephalic primordial dwarfism, Montreal type"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10235",
    "question": "What phenotype is associated with Acrofrontofacionasal dysostosis 2?",
    "seeds": [
      "Acrofrontofacionasal dysostosis 2"
    ],
    "gold_answer": "Posteriorly rotated ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10236",
    "question": "What is associated with Hyperglutaminemia?",
    "seeds": [
      "Hyperglutaminemia"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10237",
    "question": "What phenotype is associated with Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities"
    ],
    "gold_answer": "Long eyelashes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10238",
    "question": "What is associated with Cerebrooculonasal syndrome?",
    "seeds": [
      "Cerebrooculonasal syndrome"
    ],
    "gold_answer": "External genital hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10239",
    "question": "What is associated with Abnormal CSF glycine concentration?",
    "seeds": [
      "Abnormal CSF glycine concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10240",
    "question": "What is associated with Elevated circulating medium-chain acylcarnitine concentration?",
    "seeds": [
      "Elevated circulating medium-chain acylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating fatty-acid anion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10241",
    "question": "What is associated with Intermediate atrioventricular canal defect?",
    "seeds": [
      "Intermediate atrioventricular canal defect"
    ],
    "gold_answer": "Atrioventricular canal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10242",
    "question": "What is associated with Knee joint effusion?",
    "seeds": [
      "Knee joint effusion"
    ],
    "gold_answer": "Abnormality of the knee",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10243",
    "question": "What is associated with Very long chain acyl-CoA dehydrogenase deficiency?",
    "seeds": [
      "Very long chain acyl-CoA dehydrogenase deficiency"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10244",
    "question": "What is associated with Autotopagnosia?",
    "seeds": [
      "Autotopagnosia"
    ],
    "gold_answer": "Abnormal interpretation of external stimuli",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10245",
    "question": "What is associated with Onychauxis?",
    "seeds": [
      "Onychauxis"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10246",
    "question": "What is associated with Decreased fibular diameter?",
    "seeds": [
      "Decreased fibular diameter"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10247",
    "question": "What is associated with Anterior segment dysgenesis 8?",
    "seeds": [
      "Anterior segment dysgenesis 8"
    ],
    "gold_answer": "Aplasia/Hypoplasia affecting the uvea",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10248",
    "question": "What is associated with Melanoma-Pancreatic cancer syndrome?",
    "seeds": [
      "Melanoma-Pancreatic cancer syndrome"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10249",
    "question": "What is associated with Unbalanced atrioventricular canal defect?",
    "seeds": [
      "Unbalanced atrioventricular canal defect"
    ],
    "gold_answer": "Abnormal cardiac septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10250",
    "question": "What is associated with Cataract 15, multiple types?",
    "seeds": [
      "Cataract 15, multiple types"
    ],
    "gold_answer": "Zonular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10251",
    "question": "What is associated with Corner fracture of metaphysis?",
    "seeds": [
      "Corner fracture of metaphysis"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10252",
    "question": "What is associated with Zebra body myopathy?",
    "seeds": [
      "Zebra body myopathy"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10253",
    "question": "What is associated with Activated PI3K-delta syndrome?",
    "seeds": [
      "Activated PI3K-delta syndrome"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10254",
    "question": "What is associated with Overfolded helix?",
    "seeds": [
      "Overfolded helix"
    ],
    "gold_answer": "Abnormal helix morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10255",
    "question": "What is associated with Neurodevelopmental disorder with epilepsy and hemochromatosis?",
    "seeds": [
      "Neurodevelopmental disorder with epilepsy and hemochromatosis"
    ],
    "gold_answer": "Action tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10256",
    "question": "What phenotype is associated with Primary myelofibrosis?",
    "seeds": [
      "Primary myelofibrosis"
    ],
    "gold_answer": "Hepatomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10257",
    "question": "What is associated with Severe postnatal growth retardation?",
    "seeds": [
      "Severe postnatal growth retardation"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10258",
    "question": "What is associated with Greenberg skeletal dysplasia?",
    "seeds": [
      "Greenberg skeletal dysplasia"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10259",
    "question": "What is associated with Tricuspid valve prolapse?",
    "seeds": [
      "Tricuspid valve prolapse"
    ],
    "gold_answer": "Abnormal atrioventricular valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10260",
    "question": "What is associated with Distally placed thumb?",
    "seeds": [
      "Distally placed thumb"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10261",
    "question": "What phenotype is associated with Alpha-mannosidosis?",
    "seeds": [
      "Alpha-mannosidosis"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10262",
    "question": "What is associated with Orthostatic hypotension 2?",
    "seeds": [
      "Orthostatic hypotension 2"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10263",
    "question": "What is associated with Breath-holding spell?",
    "seeds": [
      "Breath-holding spell"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10264",
    "question": "What is associated with Abnormal CD69 upregulation upon TCR activation?",
    "seeds": [
      "Abnormal CD69 upregulation upon TCR activation"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10265",
    "question": "What is associated with Hepatic arteriovenous malformation?",
    "seeds": [
      "Hepatic arteriovenous malformation"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10266",
    "question": "What is associated with Impaired glucose tolerance?",
    "seeds": [
      "Impaired glucose tolerance"
    ],
    "gold_answer": "Glucose intolerance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10267",
    "question": "What is associated with Bowing of the legs?",
    "seeds": [
      "Bowing of the legs"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10268",
    "question": "What is associated with Abnormality of the submandibular region?",
    "seeds": [
      "Abnormality of the submandibular region"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10269",
    "question": "What is associated with Glomerular endocapillary neutrophil hypercellularity?",
    "seeds": [
      "Glomerular endocapillary neutrophil hypercellularity"
    ],
    "gold_answer": "Abnormal glomerular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10270",
    "question": "What is associated with Reduced fetal femur/foot length ratio?",
    "seeds": [
      "Reduced fetal femur/foot length ratio"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10271",
    "question": "What is associated with Metacarpal diaphyseal endosteal sclerosis?",
    "seeds": [
      "Metacarpal diaphyseal endosteal sclerosis"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10272",
    "question": "What is associated with Pemphigus vulgaris?",
    "seeds": [
      "Pemphigus vulgaris"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10273",
    "question": "What is associated with Bilateral triphalangeal thumbs?",
    "seeds": [
      "Bilateral triphalangeal thumbs"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10274",
    "question": "What is associated with Caudal appendage?",
    "seeds": [
      "Caudal appendage"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10275",
    "question": "What phenotype is associated with 3p25.3 microdeletion syndrome?",
    "seeds": [
      "3p25.3 microdeletion syndrome"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10276",
    "question": "What is associated with Abnormal humeral metaphysis morphology?",
    "seeds": [
      "Abnormal humeral metaphysis morphology"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10277",
    "question": "What is associated with Osteogenesis imperfecta, type XIX?",
    "seeds": [
      "Osteogenesis imperfecta, type XIX"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10278",
    "question": "What is associated with Ivory epiphysis of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Ivory epiphysis of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10279",
    "question": "What phenotype is associated with Porencephaly?",
    "seeds": [
      "Porencephaly"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10280",
    "question": "What is associated with Rhabdoid tumor of the kidney?",
    "seeds": [
      "Rhabdoid tumor of the kidney"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10281",
    "question": "What is associated with Hereditary spherocytosis?",
    "seeds": [
      "Hereditary spherocytosis"
    ],
    "gold_answer": "Abnormal mean corpuscular hemoglobin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10282",
    "question": "What is associated with Abnormal external nose morphology?",
    "seeds": [
      "Abnormal external nose morphology"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10283",
    "question": "What is associated with Anti-NMDA receptor antibody positivity?",
    "seeds": [
      "Anti-NMDA receptor antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10284",
    "question": "What is associated with Cotard delusion?",
    "seeds": [
      "Cotard delusion"
    ],
    "gold_answer": "Delusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10285",
    "question": "What is associated with Anti-phosphatidyl serine antibody positivity?",
    "seeds": [
      "Anti-phosphatidyl serine antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10286",
    "question": "What is associated with Increased fetal long bone echogenicity?",
    "seeds": [
      "Increased fetal long bone echogenicity"
    ],
    "gold_answer": "Abnormal fetal long-bone echogenicity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10287",
    "question": "What is associated with Aquagenic urticaria?",
    "seeds": [
      "Aquagenic urticaria"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10288",
    "question": "What is associated with Absent lanugo?",
    "seeds": [
      "Absent lanugo"
    ],
    "gold_answer": "Abnormal fetal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10289",
    "question": "What is associated with Abnormal sixth cranial nerve morphology?",
    "seeds": [
      "Abnormal sixth cranial nerve morphology"
    ],
    "gold_answer": "Abnormal cranial nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10290",
    "question": "What phenotype is associated with Impacted teeth, multiple?",
    "seeds": [
      "Impacted teeth, multiple"
    ],
    "gold_answer": "Supernumerary tooth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10291",
    "question": "What is associated with Decreased urinary neopterin level?",
    "seeds": [
      "Decreased urinary neopterin level"
    ],
    "gold_answer": "Abnormal urinary nitrogen compound level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10292",
    "question": "What is associated with Ocular pterygium-digital keloid dysplasia syndrome?",
    "seeds": [
      "Ocular pterygium-digital keloid dysplasia syndrome"
    ],
    "gold_answer": "Soft tissue sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10293",
    "question": "What is associated with Ventricular arrhythmia?",
    "seeds": [
      "Ventricular arrhythmia"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10294",
    "question": "What is associated with Aplasia/Hypoplasia of the phalanges of the 4th finger?",
    "seeds": [
      "Aplasia/Hypoplasia of the phalanges of the 4th finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10295",
    "question": "What is associated with Decreased RTE CD4+ T cell proportion?",
    "seeds": [
      "Decreased RTE CD4+ T cell proportion"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10296",
    "question": "What is associated with Abnormally shaped carpal bones?",
    "seeds": [
      "Abnormally shaped carpal bones"
    ],
    "gold_answer": "Abnormal wrist morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10297",
    "question": "What is associated with Uncombable hair syndrome 1?",
    "seeds": [
      "Uncombable hair syndrome 1"
    ],
    "gold_answer": "Abnormality of hair texture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10298",
    "question": "What is associated with Triangular epiphyses of the 4th toe?",
    "seeds": [
      "Triangular epiphyses of the 4th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10299",
    "question": "What is associated with Hypergranulosis?",
    "seeds": [
      "Hypergranulosis"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10300",
    "question": "What is associated with L-Arginine:glycine amidinotransferase deficiency?",
    "seeds": [
      "L-Arginine:glycine amidinotransferase deficiency"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10301",
    "question": "What is associated with Melanoma-Pancreatic cancer syndrome?",
    "seeds": [
      "Melanoma-Pancreatic cancer syndrome"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10302",
    "question": "What is associated with Aplasia of the phalanges of the hallux?",
    "seeds": [
      "Aplasia of the phalanges of the hallux"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10303",
    "question": "What is associated with Meleda disease?",
    "seeds": [
      "Meleda disease"
    ],
    "gold_answer": "Abnormality of skin adnexa physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10304",
    "question": "What is associated with Increased red cell osmotic resistance?",
    "seeds": [
      "Increased red cell osmotic resistance"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10305",
    "question": "What is associated with Impaired transferring ability?",
    "seeds": [
      "Impaired transferring ability"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10306",
    "question": "What is associated with Focal hemiclonic seizure?",
    "seeds": [
      "Focal hemiclonic seizure"
    ],
    "gold_answer": "Focal clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10307",
    "question": "What is associated with Large cafe-au-lait macules with irregular margins?",
    "seeds": [
      "Large cafe-au-lait macules with irregular margins"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10308",
    "question": "What is associated with Severe platyspondyly?",
    "seeds": [
      "Severe platyspondyly"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10309",
    "question": "What is associated with Distal radioulnar joint space widening?",
    "seeds": [
      "Distal radioulnar joint space widening"
    ],
    "gold_answer": "Abnormal forearm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10310",
    "question": "What phenotype is associated with Focal segmental glomerulosclerosis and neurodevelopmental syndrome?",
    "seeds": [
      "Focal segmental glomerulosclerosis and neurodevelopmental syndrome"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10311",
    "question": "What is associated with Hyperglycerolemia?",
    "seeds": [
      "Hyperglycerolemia"
    ],
    "gold_answer": "Abnormal circulating carbohydrate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10312",
    "question": "What is associated with Abnormal fifth cranial nerve physiology?",
    "seeds": [
      "Abnormal fifth cranial nerve physiology"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10313",
    "question": "What phenotype is associated with Complement component 8 deficiency, type I?",
    "seeds": [
      "Complement component 8 deficiency, type I"
    ],
    "gold_answer": "Retinopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10314",
    "question": "What is associated with Decreased HLA DR+ CD8+ T cell proportion?",
    "seeds": [
      "Decreased HLA DR+ CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal HLA DR+ CD8+ T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10315",
    "question": "What phenotype is associated with Teeth, odd shapes oflobodontia, included?",
    "seeds": [
      "Teeth, odd shapes oflobodontia, included"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10316",
    "question": "What is associated with Tube feeding?",
    "seeds": [
      "Tube feeding"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10317",
    "question": "What is associated with Hypoglycemia of infancy, leucine-sensitive?",
    "seeds": [
      "Hypoglycemia of infancy, leucine-sensitive"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10318",
    "question": "What phenotype is associated with Deafness, X-linked 4?",
    "seeds": [
      "Deafness, X-linked 4"
    ],
    "gold_answer": "High-frequency hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10319",
    "question": "What is associated with Lymphangiosarcoma?",
    "seeds": [
      "Lymphangiosarcoma"
    ],
    "gold_answer": "Vascular neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10320",
    "question": "What is associated with Evans syndrome?",
    "seeds": [
      "Evans syndrome"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10321",
    "question": "What is associated with History of gastric bypass surgery?",
    "seeds": [
      "History of gastric bypass surgery"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10322",
    "question": "What is associated with Mitochondrial complex IV deficiency, nuclear type 20?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 20"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10323",
    "question": "What is associated with Mismatch repair cancer syndrome 3?",
    "seeds": [
      "Mismatch repair cancer syndrome 3"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10324",
    "question": "What is associated with Absent cupid's bow?",
    "seeds": [
      "Absent cupid's bow"
    ],
    "gold_answer": "Abnormality of upper lip vermillion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10325",
    "question": "What is associated with Dystonia with cerebellar atrophy?",
    "seeds": [
      "Dystonia with cerebellar atrophy"
    ],
    "gold_answer": "Abnormal esophagus physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10326",
    "question": "What is associated with Abnormal circulating thyroglobulin concentration?",
    "seeds": [
      "Abnormal circulating thyroglobulin concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10327",
    "question": "What is associated with Silent hypoxemia?",
    "seeds": [
      "Silent hypoxemia"
    ],
    "gold_answer": "Hypoxemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10328",
    "question": "What is associated with Parkinson disease 14, autosomal recessive?",
    "seeds": [
      "Parkinson disease 14, autosomal recessive"
    ],
    "gold_answer": "DAO",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10329",
    "question": "What is associated with Abnormal CSF guanidinoacetic acid concentration?",
    "seeds": [
      "Abnormal CSF guanidinoacetic acid concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10330",
    "question": "What is associated with Increased circulating cortisol level?",
    "seeds": [
      "Increased circulating cortisol level"
    ],
    "gold_answer": "Abnormality of adrenal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10331",
    "question": "What is associated with Eosinophilic pneumonia?",
    "seeds": [
      "Eosinophilic pneumonia"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10332",
    "question": "What is associated with Autoimmune limbic encephalitis?",
    "seeds": [
      "Autoimmune limbic encephalitis"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10333",
    "question": "What is associated with Positive norpropoxyphene blood test?",
    "seeds": [
      "Positive norpropoxyphene blood test"
    ],
    "gold_answer": "Blood xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10334",
    "question": "What phenotype is associated with Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome?",
    "seeds": [
      "Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome"
    ],
    "gold_answer": "Micropenis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10335",
    "question": "What is associated with Asthma?",
    "seeds": [
      "Asthma"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10336",
    "question": "What is associated with Nephroblastomatosis?",
    "seeds": [
      "Nephroblastomatosis"
    ],
    "gold_answer": "Renal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10337",
    "question": "What is associated with Anti-NMDA receptor antibody positivity?",
    "seeds": [
      "Anti-NMDA receptor antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10338",
    "question": "What is associated with Atypical mycobacteriosis, familial, X-linked 2?",
    "seeds": [
      "Atypical mycobacteriosis, familial, X-linked 2"
    ],
    "gold_answer": "Recurrent bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10339",
    "question": "What is associated with Reticular dysgenesia?",
    "seeds": [
      "Reticular dysgenesia"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10340",
    "question": "What phenotype is associated with Microtia, first degree?",
    "seeds": [
      "Microtia, first degree"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10341",
    "question": "What phenotype is associated with Congenital heart defects, multiple types, 3?",
    "seeds": [
      "Congenital heart defects, multiple types, 3"
    ],
    "gold_answer": "Tachycardia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10342",
    "question": "What is associated with Lymphadenopathy?",
    "seeds": [
      "Lymphadenopathy"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10343",
    "question": "What is associated with Immunodeficiency, common variable, 15?",
    "seeds": [
      "Immunodeficiency, common variable, 15"
    ],
    "gold_answer": "Abnormality of the tonsils",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10344",
    "question": "What is associated with Grandiosity?",
    "seeds": [
      "Grandiosity"
    ],
    "gold_answer": "Abnormal preoccupation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10345",
    "question": "What is associated with Joint swelling?",
    "seeds": [
      "Joint swelling"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10346",
    "question": "What is associated with MHC class II deficiency 2?",
    "seeds": [
      "MHC class II deficiency 2"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10347",
    "question": "What is associated with Absent proximal phalanx of the 3rd toe?",
    "seeds": [
      "Absent proximal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal morphology of the proximal phalanx of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10348",
    "question": "What is associated with Ectodermal dysplasia 11A, hypohidrotic/hair/tooth type, autosomal dominant?",
    "seeds": [
      "Ectodermal dysplasia 11A, hypohidrotic/hair/tooth type, autosomal dominant"
    ],
    "gold_answer": "Abnormal dental root morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10349",
    "question": "What is associated with Wide penis?",
    "seeds": [
      "Wide penis"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10350",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 64?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 64"
    ],
    "gold_answer": "Slurred speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10351",
    "question": "What is associated with Aplasia/Hypoplasia of the pancreas?",
    "seeds": [
      "Aplasia/Hypoplasia of the pancreas"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10352",
    "question": "What is associated with Transposition of the great arteries?",
    "seeds": [
      "Transposition of the great arteries"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10353",
    "question": "What phenotype is associated with Dyskeratosis congenita, autosomal recessive 1?",
    "seeds": [
      "Dyskeratosis congenita, autosomal recessive 1"
    ],
    "gold_answer": "Pancytopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10354",
    "question": "What is associated with Atrioventricular septal defect 4?",
    "seeds": [
      "Atrioventricular septal defect 4"
    ],
    "gold_answer": "Abnormal atrial septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10355",
    "question": "What is associated with Abnormal common tendinous ring morphology?",
    "seeds": [
      "Abnormal common tendinous ring morphology"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10356",
    "question": "What is associated with Chronic lymphoproliferative disorder of natural killer cells?",
    "seeds": [
      "Chronic lymphoproliferative disorder of natural killer cells"
    ],
    "gold_answer": "STAT3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10357",
    "question": "What is associated with Posterior mediastinal mass?",
    "seeds": [
      "Posterior mediastinal mass"
    ],
    "gold_answer": "Mediastinal mass",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10358",
    "question": "What is associated with Myopathy, congenital, with fiber-type disproportion?",
    "seeds": [
      "Myopathy, congenital, with fiber-type disproportion"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10359",
    "question": "What is associated with Phacoanaphylactic uveitis?",
    "seeds": [
      "Phacoanaphylactic uveitis"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10360",
    "question": "What is associated with Autism with high cognitive abilities?",
    "seeds": [
      "Autism with high cognitive abilities"
    ],
    "gold_answer": "Autistic behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10361",
    "question": "What is associated with Fanconi anemia, complementation group D1?",
    "seeds": [
      "Fanconi anemia, complementation group D1"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10362",
    "question": "What is associated with Epilepsy, nocturnal frontal lobe, type 1?",
    "seeds": [
      "Epilepsy, nocturnal frontal lobe, type 1"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10363",
    "question": "What phenotype is associated with Leukoencephalopathy, porphyria-related?",
    "seeds": [
      "Leukoencephalopathy, porphyria-related"
    ],
    "gold_answer": "Sensorimotor neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10364",
    "question": "What phenotype is associated with Retinitis pigmentosa 4?",
    "seeds": [
      "Retinitis pigmentosa 4"
    ],
    "gold_answer": "Pigmentary retinopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10365",
    "question": "What is associated with Abnormal scaphoid morphology?",
    "seeds": [
      "Abnormal scaphoid morphology"
    ],
    "gold_answer": "Abnormal wrist morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10366",
    "question": "What is associated with Flattened metatarsal heads?",
    "seeds": [
      "Flattened metatarsal heads"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10367",
    "question": "What is associated with Neurodevelopmental disorder with dystonia and seizures?",
    "seeds": [
      "Neurodevelopmental disorder with dystonia and seizures"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10368",
    "question": "What is associated with Abnormal circulating carnitine concentration?",
    "seeds": [
      "Abnormal circulating carnitine concentration"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10369",
    "question": "What is associated with Square humeral metaphysis?",
    "seeds": [
      "Square humeral metaphysis"
    ],
    "gold_answer": "Abnormal upper limb metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10370",
    "question": "What phenotype is associated with Hypermethioninemia due to adenosine kinase deficiency?",
    "seeds": [
      "Hypermethioninemia due to adenosine kinase deficiency"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10371",
    "question": "What is associated with Waardenburg syndrome type 2?",
    "seeds": [
      "Waardenburg syndrome type 2"
    ],
    "gold_answer": "Abnormal enteric ganglion morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10372",
    "question": "What is associated with Best corrected visual acuity 0.5 LogMAR?",
    "seeds": [
      "Best corrected visual acuity 0.5 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10373",
    "question": "What is associated with Familial isolated hypoparathyroidism due to agenesis of parathyroid gland?",
    "seeds": [
      "Familial isolated hypoparathyroidism due to agenesis of parathyroid gland"
    ],
    "gold_answer": "Abnormal magnesium concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10374",
    "question": "What is associated with Neuromuscular dysphagia?",
    "seeds": [
      "Neuromuscular dysphagia"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10375",
    "question": "What is associated with Clumping of lymph node lymphocyte chromatin?",
    "seeds": [
      "Clumping of lymph node lymphocyte chromatin"
    ],
    "gold_answer": "Abnormal lymph-node lymphoctye nuclear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10376",
    "question": "What is associated with Cone dystrophy 3?",
    "seeds": [
      "Cone dystrophy 3"
    ],
    "gold_answer": "Sensory behavioral abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10377",
    "question": "What is associated with Pulmonary hypertension, primary, 2?",
    "seeds": [
      "Pulmonary hypertension, primary, 2"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10378",
    "question": "What is associated with Positive respiratory tract SARS-CoV-2 coronavirus nucleic acid test?",
    "seeds": [
      "Positive respiratory tract SARS-CoV-2 coronavirus nucleic acid test"
    ],
    "gold_answer": "Positive respiratory tract nucleic acid pathogen test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10379",
    "question": "What phenotype is associated with Spermatogenic failure 44?",
    "seeds": [
      "Spermatogenic failure 44"
    ],
    "gold_answer": "Male infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10380",
    "question": "What is associated with Lymphangioleiomyomatosis?",
    "seeds": [
      "Lymphangioleiomyomatosis"
    ],
    "gold_answer": "Neoplasm of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10381",
    "question": "What is associated with Infantile systemic hyalinosis?",
    "seeds": [
      "Infantile systemic hyalinosis"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10382",
    "question": "What is associated with Abnormal nonverbal communicative behavior?",
    "seeds": [
      "Abnormal nonverbal communicative behavior"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10383",
    "question": "What is associated with Microscopic hematuria?",
    "seeds": [
      "Microscopic hematuria"
    ],
    "gold_answer": "Abnormal urine cytology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10384",
    "question": "What is associated with Myelodysplasia?",
    "seeds": [
      "Myelodysplasia"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10385",
    "question": "What is associated with Decreased circulating vitamin C concentration?",
    "seeds": [
      "Decreased circulating vitamin C concentration"
    ],
    "gold_answer": "Abnormality of vitamin C metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10386",
    "question": "What is associated with ALG13-CDG?",
    "seeds": [
      "ALG13-CDG"
    ],
    "gold_answer": "EEG with generalized epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10387",
    "question": "What is associated with Reduced social responsiveness?",
    "seeds": [
      "Reduced social responsiveness"
    ],
    "gold_answer": "Abnormal social development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10388",
    "question": "What is associated with Sloping radial epiphyses?",
    "seeds": [
      "Sloping radial epiphyses"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10389",
    "question": "What is associated with Brain malformation renal syndrome?",
    "seeds": [
      "Brain malformation renal syndrome"
    ],
    "gold_answer": "Glaucoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10390",
    "question": "What is associated with Elevated brain creatine level by MRS?",
    "seeds": [
      "Elevated brain creatine level by MRS"
    ],
    "gold_answer": "Brain imaging abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10391",
    "question": "What is associated with Neurenteric cyst?",
    "seeds": [
      "Neurenteric cyst"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10392",
    "question": "What is associated with Congenital bilateral ptosis?",
    "seeds": [
      "Congenital bilateral ptosis"
    ],
    "gold_answer": "Bilateral ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10393",
    "question": "What phenotype is associated with Immunodeficiency 134 (Epstein-Barr virus-specific)?",
    "seeds": [
      "Immunodeficiency 134 (Epstein-Barr virus-specific)"
    ],
    "gold_answer": "Pharyngalgia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10394",
    "question": "What is associated with Acheiropody?",
    "seeds": [
      "Acheiropody"
    ],
    "gold_answer": "Abnormal forearm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10395",
    "question": "What is associated with Abnormal motor nerve conduction velocity?",
    "seeds": [
      "Abnormal motor nerve conduction velocity"
    ],
    "gold_answer": "Abnormality of peripheral nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10396",
    "question": "What is associated with Decreased circulating carboxypeptidase N activity?",
    "seeds": [
      "Decreased circulating carboxypeptidase N activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10397",
    "question": "What is associated with Elevated serum acid phosphatase?",
    "seeds": [
      "Elevated serum acid phosphatase"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10398",
    "question": "What is associated with Abnormal circulating IgD concentration?",
    "seeds": [
      "Abnormal circulating IgD concentration"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10399",
    "question": "What is associated with Eccrine syringofibroadenoma?",
    "seeds": [
      "Eccrine syringofibroadenoma"
    ],
    "gold_answer": "Neoplasm of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10400",
    "question": "What is associated with Decreased CSF glutamine concentration?",
    "seeds": [
      "Decreased CSF glutamine concentration"
    ],
    "gold_answer": "Abnormal CSF glutamine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10401",
    "question": "What is associated with Mitochondrial complex III deficiency, nuclear type 2?",
    "seeds": [
      "Mitochondrial complex III deficiency, nuclear type 2"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10402",
    "question": "What is associated with Spherocytosis, type 2?",
    "seeds": [
      "Spherocytosis, type 2"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10403",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2D?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2D"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10404",
    "question": "What is associated with Beemer-Ertbruggen syndrome?",
    "seeds": [
      "Beemer-Ertbruggen syndrome"
    ],
    "gold_answer": "Abnormality of the philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10405",
    "question": "What is associated with Microcephaly 26, primary, autosomal dominant?",
    "seeds": [
      "Microcephaly 26, primary, autosomal dominant"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10406",
    "question": "What is associated with Abnormal pulmonary vein physiology?",
    "seeds": [
      "Abnormal pulmonary vein physiology"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10407",
    "question": "What is associated with Dull?",
    "seeds": [
      "Dull"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10408",
    "question": "What is associated with Osteochondromyxoma?",
    "seeds": [
      "Osteochondromyxoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10409",
    "question": "What is associated with Follicular lymphoma?",
    "seeds": [
      "Follicular lymphoma"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10410",
    "question": "What is associated with Abnormal muscle succinate dehydrogenase staining?",
    "seeds": [
      "Abnormal muscle succinate dehydrogenase staining"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10411",
    "question": "What is associated with Abnormal neck physiology?",
    "seeds": [
      "Abnormal neck physiology"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10412",
    "question": "What is associated with Lymph-node capsular invasion by lymphocytes?",
    "seeds": [
      "Lymph-node capsular invasion by lymphocytes"
    ],
    "gold_answer": "Abnormal lymph-node tissue architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10413",
    "question": "What phenotype is associated with DIASTEMATOMYELIA?",
    "seeds": [
      "DIASTEMATOMYELIA"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10414",
    "question": "What is associated with Perseverative thought?",
    "seeds": [
      "Perseverative thought"
    ],
    "gold_answer": "Abnormal cognitive process",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10415",
    "question": "What is associated with Pulmonary carcinoid tumor?",
    "seeds": [
      "Pulmonary carcinoid tumor"
    ],
    "gold_answer": "Carcinoid tumor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10416",
    "question": "What is associated with Metaphyseal spurs?",
    "seeds": [
      "Metaphyseal spurs"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10417",
    "question": "What is associated with EMG: axonal abnormality?",
    "seeds": [
      "EMG: axonal abnormality"
    ],
    "gold_answer": "EMG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10418",
    "question": "What is associated with Cortical radial artery intraluminal thrombi?",
    "seeds": [
      "Cortical radial artery intraluminal thrombi"
    ],
    "gold_answer": "Abnormal cortical radial artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10419",
    "question": "What is associated with Omphalocele?",
    "seeds": [
      "Omphalocele"
    ],
    "gold_answer": "Abnormal abdominal wall morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10420",
    "question": "What is associated with Hypodontia?",
    "seeds": [
      "Hypodontia"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10421",
    "question": "What is associated with Severe influenza infection?",
    "seeds": [
      "Severe influenza infection"
    ],
    "gold_answer": "Severe infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10422",
    "question": "What is associated with Oculocutaneous albinism type 1A?",
    "seeds": [
      "Oculocutaneous albinism type 1A"
    ],
    "gold_answer": "Generalized hypopigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10423",
    "question": "What is associated with Straight clavicles?",
    "seeds": [
      "Straight clavicles"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10424",
    "question": "What is associated with Elevated circulating C-terminal fibroblast growth factor 23 concentration?",
    "seeds": [
      "Elevated circulating C-terminal fibroblast growth factor 23 concentration"
    ],
    "gold_answer": "Abnormal circulating fibroblast growth factor 23 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10425",
    "question": "What phenotype is associated with KINSSHIP syndrome?",
    "seeds": [
      "KINSSHIP syndrome"
    ],
    "gold_answer": "Polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10426",
    "question": "What is associated with Renal cortical necrosis?",
    "seeds": [
      "Renal cortical necrosis"
    ],
    "gold_answer": "Abnormal renal cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10427",
    "question": "What is associated with Abnormal cortical radial artery endothelium morphology?",
    "seeds": [
      "Abnormal cortical radial artery endothelium morphology"
    ],
    "gold_answer": "Abnormal intrarenal artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10428",
    "question": "What is associated with Partial duplication of phalanx of the 2nd toe?",
    "seeds": [
      "Partial duplication of phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal 2nd toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10429",
    "question": "What is associated with Pontocerebellar hypoplasia type 3?",
    "seeds": [
      "Pontocerebellar hypoplasia type 3"
    ],
    "gold_answer": "PCLO",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10430",
    "question": "What is associated with Contracture of the proximal interphalangeal joint of the 4th toe?",
    "seeds": [
      "Contracture of the proximal interphalangeal joint of the 4th toe"
    ],
    "gold_answer": "Toe joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10431",
    "question": "What phenotype is associated with Atelosteogenesis, type III?",
    "seeds": [
      "Atelosteogenesis, type III"
    ],
    "gold_answer": "Widened distal phalanges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10432",
    "question": "What is associated with Fragmentation of the epiphysis of the 1st metacarpal?",
    "seeds": [
      "Fragmentation of the epiphysis of the 1st metacarpal"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10433",
    "question": "What phenotype is associated with Agammaglobulinemia 9, autosomal recessive?",
    "seeds": [
      "Agammaglobulinemia 9, autosomal recessive"
    ],
    "gold_answer": "Absent circulating B cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10434",
    "question": "What is associated with Delayed eruption of primary teeth?",
    "seeds": [
      "Delayed eruption of primary teeth"
    ],
    "gold_answer": "Delayed eruption of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10435",
    "question": "What is associated with Abnormality of tumor necrosis factor secretion?",
    "seeds": [
      "Abnormality of tumor necrosis factor secretion"
    ],
    "gold_answer": "Abnormality of cytokine secretion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10436",
    "question": "What is associated with Basilar impression, primary?",
    "seeds": [
      "Basilar impression, primary"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10437",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 76?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 76"
    ],
    "gold_answer": "Renal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10438",
    "question": "What is associated with Low intraocular pressure?",
    "seeds": [
      "Low intraocular pressure"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10439",
    "question": "What is associated with Supernumerary vertebrae?",
    "seeds": [
      "Supernumerary vertebrae"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10440",
    "question": "What is associated with Morbus Kienboeck?",
    "seeds": [
      "Morbus Kienboeck"
    ],
    "gold_answer": "Avascular necrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10441",
    "question": "What is associated with Parathyroid carcinoma?",
    "seeds": [
      "Parathyroid carcinoma"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10442",
    "question": "What is associated with Hypoplastic cervical vertebrae?",
    "seeds": [
      "Hypoplastic cervical vertebrae"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10443",
    "question": "What phenotype is associated with Arthrogryposis multiplex congenita 3, myogenic type?",
    "seeds": [
      "Arthrogryposis multiplex congenita 3, myogenic type"
    ],
    "gold_answer": "Talipes equinovarus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10444",
    "question": "What is associated with Posterior embryotoxon?",
    "seeds": [
      "Posterior embryotoxon"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10445",
    "question": "What is associated with Microspherocytosis?",
    "seeds": [
      "Microspherocytosis"
    ],
    "gold_answer": "Poikilocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10446",
    "question": "What phenotype is associated with Lowe-Kohn-Cohen syndrome?",
    "seeds": [
      "Lowe-Kohn-Cohen syndrome"
    ],
    "gold_answer": "Anal atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10447",
    "question": "What is associated with Abnormal ocular alignment?",
    "seeds": [
      "Abnormal ocular alignment"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10448",
    "question": "What is associated with Brain stem compression?",
    "seeds": [
      "Brain stem compression"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10449",
    "question": "What is associated with 4-layered lissencephaly?",
    "seeds": [
      "4-layered lissencephaly"
    ],
    "gold_answer": "Lissencephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10450",
    "question": "What is associated with Enlarged epiphyses of the 3rd finger?",
    "seeds": [
      "Enlarged epiphyses of the 3rd finger"
    ],
    "gold_answer": "Enlarged epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10451",
    "question": "What is associated with Retinitis pigmentosa 83?",
    "seeds": [
      "Retinitis pigmentosa 83"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10452",
    "question": "What is associated with Intranuclear cardiomyocyte mitochondria?",
    "seeds": [
      "Intranuclear cardiomyocyte mitochondria"
    ],
    "gold_answer": "Abnormal cardiomyocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10453",
    "question": "What is associated with Episodic quadriplegia?",
    "seeds": [
      "Episodic quadriplegia"
    ],
    "gold_answer": "Weakness due to upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10454",
    "question": "What is associated with Limited repertoire of facial expression?",
    "seeds": [
      "Limited repertoire of facial expression"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10455",
    "question": "What is associated with Prominent calcaneus?",
    "seeds": [
      "Prominent calcaneus"
    ],
    "gold_answer": "Abnormality of the calcaneus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10456",
    "question": "What phenotype is associated with Phosphoenolpyruvate carboxykinase 2, mitochondrial?",
    "seeds": [
      "Phosphoenolpyruvate carboxykinase 2, mitochondrial"
    ],
    "gold_answer": "Hepatic steatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10457",
    "question": "What phenotype is associated with Proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis?",
    "seeds": [
      "Proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis"
    ],
    "gold_answer": "Hyposthenuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10458",
    "question": "What is associated with Reticular dystrophy of the retinal pigment epithelium?",
    "seeds": [
      "Reticular dystrophy of the retinal pigment epithelium"
    ],
    "gold_answer": "RCBTB1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10459",
    "question": "What is associated with Trichothiodystrophy 4, nonphotosensitive?",
    "seeds": [
      "Trichothiodystrophy 4, nonphotosensitive"
    ],
    "gold_answer": "Agenesis of corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10460",
    "question": "What is associated with Generalized clonic seizure?",
    "seeds": [
      "Generalized clonic seizure"
    ],
    "gold_answer": "Generalized-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10461",
    "question": "What is associated with Hemoglobin-Delta locus?",
    "seeds": [
      "Hemoglobin-Delta locus"
    ],
    "gold_answer": "Abnormal hemoglobin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10462",
    "question": "What is associated with Abnormal urinary sulfate concentration?",
    "seeds": [
      "Abnormal urinary sulfate concentration"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10463",
    "question": "What is associated with Macular agenesis?",
    "seeds": [
      "Macular agenesis"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10464",
    "question": "What is associated with Kyrle disease?",
    "seeds": [
      "Kyrle disease"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10465",
    "question": "What is associated with Charcot-Marie-Tooth disease, X-linked recessive, 3?",
    "seeds": [
      "Charcot-Marie-Tooth disease, X-linked recessive, 3"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10466",
    "question": "What is associated with Thickened tibial cortex?",
    "seeds": [
      "Thickened tibial cortex"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10467",
    "question": "What is associated with Hereditary spherocytosis?",
    "seeds": [
      "Hereditary spherocytosis"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10468",
    "question": "What is associated with Abnormal circulating isoleucine concentration?",
    "seeds": [
      "Abnormal circulating isoleucine concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10469",
    "question": "What is associated with Thickened cortex of the clavicle?",
    "seeds": [
      "Thickened cortex of the clavicle"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10470",
    "question": "What is associated with Duplication of the middle phalanx of the 5th toe?",
    "seeds": [
      "Duplication of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the middle phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10471",
    "question": "What is associated with Acromegaloid facial appearance syndrome?",
    "seeds": [
      "Acromegaloid facial appearance syndrome"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10472",
    "question": "What is associated with Peripheral demyelinating neuropathy, central dysmyelination, Waardenburg syndrome, and Hirschsprung disease?",
    "seeds": [
      "Peripheral demyelinating neuropathy, central dysmyelination, Waardenburg syndrome, and Hirschsprung disease"
    ],
    "gold_answer": "Paraparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10473",
    "question": "What is associated with Osteolytic defects of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Osteolytic defects of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the proximal phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10474",
    "question": "What is associated with Excessive checking?",
    "seeds": [
      "Excessive checking"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10475",
    "question": "What is associated with Sick sinus syndrome 4?",
    "seeds": [
      "Sick sinus syndrome 4"
    ],
    "gold_answer": "Cardiac arrest",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10476",
    "question": "What is associated with Bleeding disorder, platelet-type, 16?",
    "seeds": [
      "Bleeding disorder, platelet-type, 16"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10477",
    "question": "What is associated with Accessory oral frenulum?",
    "seeds": [
      "Accessory oral frenulum"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10478",
    "question": "What is associated with Parathyroid dysgenesis?",
    "seeds": [
      "Parathyroid dysgenesis"
    ],
    "gold_answer": "Abnormal parathyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10479",
    "question": "What is associated with Absent ray?",
    "seeds": [
      "Absent ray"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10480",
    "question": "What is associated with Spermatogenic failure 10?",
    "seeds": [
      "Spermatogenic failure 10"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10481",
    "question": "What is associated with Adult onset?",
    "seeds": [
      "Adult onset"
    ],
    "gold_answer": "Onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10482",
    "question": "What is associated with Delayed brainstem auditory evoked response conduction time?",
    "seeds": [
      "Delayed brainstem auditory evoked response conduction time"
    ],
    "gold_answer": "Abnormal auditory evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10483",
    "question": "What is associated with Glomerular proteinuria?",
    "seeds": [
      "Glomerular proteinuria"
    ],
    "gold_answer": "Proteinuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10484",
    "question": "What is associated with Unusual protozoan infection?",
    "seeds": [
      "Unusual protozoan infection"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10485",
    "question": "What is associated with Upper limb phocomelia?",
    "seeds": [
      "Upper limb phocomelia"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10486",
    "question": "What is associated with Left ventricular noncompaction 8?",
    "seeds": [
      "Left ventricular noncompaction 8"
    ],
    "gold_answer": "Abnormal morphology of myocardial trabeculae",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10487",
    "question": "What is associated with Limited elbow flexion?",
    "seeds": [
      "Limited elbow flexion"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10488",
    "question": "What phenotype is associated with Cholangiocarcinoma?",
    "seeds": [
      "Cholangiocarcinoma"
    ],
    "gold_answer": "Acholic stools",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10489",
    "question": "What is associated with Palmoplantar keratoderma, epidermolytic?",
    "seeds": [
      "Palmoplantar keratoderma, epidermolytic"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10490",
    "question": "What phenotype is associated with Retinitis pigmentosa 36?",
    "seeds": [
      "Retinitis pigmentosa 36"
    ],
    "gold_answer": "Macular degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10491",
    "question": "What is associated with Congenital disorder of glycosylation, type Iip?",
    "seeds": [
      "Congenital disorder of glycosylation, type Iip"
    ],
    "gold_answer": "Abnormal abdomen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10492",
    "question": "What is associated with Abnormal fibular epiphysis morphology?",
    "seeds": [
      "Abnormal fibular epiphysis morphology"
    ],
    "gold_answer": "Abnormal limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10493",
    "question": "What is associated with Ivory epiphyses?",
    "seeds": [
      "Ivory epiphyses"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10494",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 14?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 14"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10495",
    "question": "What is associated with Focal impaired awareness motor seizure with paresis/paralysis?",
    "seeds": [
      "Focal impaired awareness motor seizure with paresis/paralysis"
    ],
    "gold_answer": "Focal motor seizure with paresis/paralysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10496",
    "question": "What is associated with Open fracture?",
    "seeds": [
      "Open fracture"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10497",
    "question": "What is associated with Hyperkalemia?",
    "seeds": [
      "Hyperkalemia"
    ],
    "gold_answer": "Abnormal blood monovalent inorganic cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10498",
    "question": "What is associated with Flat face-microstomia-ear anomaly syndrome?",
    "seeds": [
      "Flat face-microstomia-ear anomaly syndrome"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10499",
    "question": "What is associated with Reduced anterior scleral thickness?",
    "seeds": [
      "Reduced anterior scleral thickness"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10500",
    "question": "What is associated with Neoplasm of the peripheral nervous system?",
    "seeds": [
      "Neoplasm of the peripheral nervous system"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10501",
    "question": "What is associated with Enlarged sagittal diameter of the cervical canal?",
    "seeds": [
      "Enlarged sagittal diameter of the cervical canal"
    ],
    "gold_answer": "Abnormality of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10502",
    "question": "What is associated with Telangiectasia, hereditary hemorrhagic, type 5?",
    "seeds": [
      "Telangiectasia, hereditary hemorrhagic, type 5"
    ],
    "gold_answer": "Epistaxis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10503",
    "question": "What is associated with Podocyte foot process effacement?",
    "seeds": [
      "Podocyte foot process effacement"
    ],
    "gold_answer": "Abnormal glomerular visceral epithelial cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10504",
    "question": "What is associated with Hereditary mixed polyposis syndrome?",
    "seeds": [
      "Hereditary mixed polyposis syndrome"
    ],
    "gold_answer": "Intestinal polyposis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10505",
    "question": "What is associated with Von Willebrand disease?",
    "seeds": [
      "Von Willebrand disease"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10506",
    "question": "What phenotype is associated with Short stature-wormian bones-dextrocardia syndrome?",
    "seeds": [
      "Short stature-wormian bones-dextrocardia syndrome"
    ],
    "gold_answer": "Anemic pallor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10507",
    "question": "What is associated with Caseous vernix-like desquamation?",
    "seeds": [
      "Caseous vernix-like desquamation"
    ],
    "gold_answer": "Abnormal fetal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10508",
    "question": "What is associated with Polyembryoma?",
    "seeds": [
      "Polyembryoma"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10509",
    "question": "What is associated with Dark cerumen?",
    "seeds": [
      "Dark cerumen"
    ],
    "gold_answer": "Abnormal auditory canal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10510",
    "question": "What is associated with Absent nares?",
    "seeds": [
      "Absent nares"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10511",
    "question": "What is associated with Decreased glucose-6-phosphate dehydrogenase level in tissue?",
    "seeds": [
      "Decreased glucose-6-phosphate dehydrogenase level in tissue"
    ],
    "gold_answer": "Abnormal glucose-6-phosphate dehydrogenase level in tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10512",
    "question": "What is associated with Impairment of galactose metabolism?",
    "seeds": [
      "Impairment of galactose metabolism"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10513",
    "question": "What is associated with Body odor?",
    "seeds": [
      "Body odor"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10514",
    "question": "What is associated with Abnormal CSF protein concentration?",
    "seeds": [
      "Abnormal CSF protein concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10515",
    "question": "What is associated with Cardiac polyglucosan accumulation?",
    "seeds": [
      "Cardiac polyglucosan accumulation"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10516",
    "question": "What is associated with Ameliorated by nitroglycerin?",
    "seeds": [
      "Ameliorated by nitroglycerin"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10517",
    "question": "What is associated with Abnormal vaginal physiology?",
    "seeds": [
      "Abnormal vaginal physiology"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10518",
    "question": "What is associated with Neurocutaneous melanocytosis?",
    "seeds": [
      "Neurocutaneous melanocytosis"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10519",
    "question": "What is associated with Colon cancer?",
    "seeds": [
      "Colon cancer"
    ],
    "gold_answer": "Neoplasm of the colon",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10520",
    "question": "What phenotype is associated with Meckel syndrome, type 9?",
    "seeds": [
      "Meckel syndrome, type 9"
    ],
    "gold_answer": "Occipital encephalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10521",
    "question": "What is associated with Pancreatic cysts?",
    "seeds": [
      "Pancreatic cysts"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10522",
    "question": "What phenotype is associated with Complement component 8 deficiency, type I?",
    "seeds": [
      "Complement component 8 deficiency, type I"
    ],
    "gold_answer": "Weight loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10523",
    "question": "What is associated with Fundus dystrophy, pseudoinflammatory, recessive form?",
    "seeds": [
      "Fundus dystrophy, pseudoinflammatory, recessive form"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10524",
    "question": "What is associated with Pelizaeus-Merzbacher-like disease?",
    "seeds": [
      "Pelizaeus-Merzbacher-like disease"
    ],
    "gold_answer": "MAL",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10525",
    "question": "What is associated with Leber congenital amaurosis 14?",
    "seeds": [
      "Leber congenital amaurosis 14"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10526",
    "question": "What is associated with Cystinosis, late-onset juvenile or adolescent nephropathic?",
    "seeds": [
      "Cystinosis, late-onset juvenile or adolescent nephropathic"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10527",
    "question": "What is associated with Pontocerebellar hypoplasia, type 2E?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 2E"
    ],
    "gold_answer": "Joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10528",
    "question": "What is associated with Allergic bronchopulmonary aspergillosis?",
    "seeds": [
      "Allergic bronchopulmonary aspergillosis"
    ],
    "gold_answer": "Pre-capillary pulmonary hypertension",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10529",
    "question": "What is associated with MELAS?",
    "seeds": [
      "MELAS"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10530",
    "question": "What is associated with Curved proximal phalanges of the hand?",
    "seeds": [
      "Curved proximal phalanges of the hand"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10531",
    "question": "What is associated with Metatarsus adductus?",
    "seeds": [
      "Metatarsus adductus"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10532",
    "question": "What is associated with Atherosclerosis?",
    "seeds": [
      "Atherosclerosis"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10533",
    "question": "What is associated with Small epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Small epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10534",
    "question": "What is associated with Short humerus?",
    "seeds": [
      "Short humerus"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10535",
    "question": "What is associated with Abnormality of the distal phalanx of the 4th toe?",
    "seeds": [
      "Abnormality of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10536",
    "question": "What is associated with Abnormality of vision?",
    "seeds": [
      "Abnormality of vision"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10537",
    "question": "What is associated with Epilepsy, progressive myoclonic, 10?",
    "seeds": [
      "Epilepsy, progressive myoclonic, 10"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10538",
    "question": "What is associated with Frontal encephalocele?",
    "seeds": [
      "Frontal encephalocele"
    ],
    "gold_answer": "Cephalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10539",
    "question": "What is associated with VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 1?",
    "seeds": [
      "VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 1"
    ],
    "gold_answer": "Ectopic calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10540",
    "question": "What is associated with Hepatic agenesis?",
    "seeds": [
      "Hepatic agenesis"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10541",
    "question": "What phenotype is associated with Edinburgh malformation syndrome?",
    "seeds": [
      "Edinburgh malformation syndrome"
    ],
    "gold_answer": "Subglottic stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10542",
    "question": "What is associated with Enlarged distal tibial epiphysis?",
    "seeds": [
      "Enlarged distal tibial epiphysis"
    ],
    "gold_answer": "Abnormality of tibial epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10543",
    "question": "What is associated with Aplasia of the right hemidiaphragm?",
    "seeds": [
      "Aplasia of the right hemidiaphragm"
    ],
    "gold_answer": "Abnormal right hemidiaphragm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10544",
    "question": "What is associated with Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15?",
    "seeds": [
      "Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15"
    ],
    "gold_answer": "Hypoplastic female external genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10545",
    "question": "What phenotype is associated with Isolated arrhinia?",
    "seeds": [
      "Isolated arrhinia"
    ],
    "gold_answer": "Cyclopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10546",
    "question": "What is associated with Galactosemia IV?",
    "seeds": [
      "Galactosemia IV"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10547",
    "question": "What is associated with Diffuse cerebral sclerosis?",
    "seeds": [
      "Diffuse cerebral sclerosis"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10548",
    "question": "What is associated with Increased peripheral myelin thickness?",
    "seeds": [
      "Increased peripheral myelin thickness"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10549",
    "question": "What is associated with Deviation of toes?",
    "seeds": [
      "Deviation of toes"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10550",
    "question": "What is associated with Porphyria, acute hepatic?",
    "seeds": [
      "Porphyria, acute hepatic"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10551",
    "question": "What is associated with Encopresis?",
    "seeds": [
      "Encopresis"
    ],
    "gold_answer": "Impairment of activities of daily living",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10552",
    "question": "What phenotype is associated with Agenesis of cerebral white matter?",
    "seeds": [
      "Agenesis of cerebral white matter"
    ],
    "gold_answer": "Cerebral white matter agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10553",
    "question": "What phenotype is associated with Kaposi sarcoma, susceptibility to?",
    "seeds": [
      "Kaposi sarcoma, susceptibility to"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10554",
    "question": "What is associated with Uvular swelling?",
    "seeds": [
      "Uvular swelling"
    ],
    "gold_answer": "Abnormal uvula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10555",
    "question": "What phenotype is associated with Laryngeal adductor paralysis?",
    "seeds": [
      "Laryngeal adductor paralysis"
    ],
    "gold_answer": "Hoarse voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10556",
    "question": "What is associated with Aplasia/Hypoplasia of the brainstem?",
    "seeds": [
      "Aplasia/Hypoplasia of the brainstem"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10557",
    "question": "What is associated with Foveal photoreceptor layer loss on macular OCT?",
    "seeds": [
      "Foveal photoreceptor layer loss on macular OCT"
    ],
    "gold_answer": "Abnormal foveal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10558",
    "question": "What is associated with Blepharophimosis-ptosis-epicanthus inversus syndrome?",
    "seeds": [
      "Blepharophimosis-ptosis-epicanthus inversus syndrome"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10559",
    "question": "What is associated with Recurrent bacterial upper respiratory tract infections?",
    "seeds": [
      "Recurrent bacterial upper respiratory tract infections"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10560",
    "question": "What phenotype is associated with Muscular dystrophy, limb-girdle, type 2W?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, type 2W"
    ],
    "gold_answer": "Increased connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10561",
    "question": "What is associated with Aplasia/Hypoplasia of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Aplasia/Hypoplasia of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10562",
    "question": "What phenotype is associated with Thymoma, familial?",
    "seeds": [
      "Thymoma, familial"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10563",
    "question": "What is associated with Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder?",
    "seeds": [
      "Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder"
    ],
    "gold_answer": "Abnormality of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10564",
    "question": "What is associated with Enlarged epiphyses of the 3rd finger?",
    "seeds": [
      "Enlarged epiphyses of the 3rd finger"
    ],
    "gold_answer": "Abnormal 3rd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10565",
    "question": "What is associated with Desmoplastic/nodular medulloblastoma?",
    "seeds": [
      "Desmoplastic/nodular medulloblastoma"
    ],
    "gold_answer": "SUFU",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_10566",
    "question": "What is associated with Alobar holoprosencephaly?",
    "seeds": [
      "Alobar holoprosencephaly"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10567",
    "question": "What is associated with Transitional atrioventricular canal defect?",
    "seeds": [
      "Transitional atrioventricular canal defect"
    ],
    "gold_answer": "Atrioventricular canal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10568",
    "question": "What phenotype is associated with Ataxia-pancytopenia syndrome?",
    "seeds": [
      "Ataxia-pancytopenia syndrome"
    ],
    "gold_answer": "Abnormality of the gingiva",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10569",
    "question": "What is associated with Arthrogryposis, distal, type 1B?",
    "seeds": [
      "Arthrogryposis, distal, type 1B"
    ],
    "gold_answer": "Abnormal talus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10570",
    "question": "What is associated with Noonan syndrome?",
    "seeds": [
      "Noonan syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the mandible",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10571",
    "question": "What phenotype is associated with Acute lung injury?",
    "seeds": [
      "Acute lung injury"
    ],
    "gold_answer": "Hypoxemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10572",
    "question": "What phenotype is associated with Constricting bands, congenital?",
    "seeds": [
      "Constricting bands, congenital"
    ],
    "gold_answer": "Gastroschisis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10573",
    "question": "What is associated with Incomplete partition of the cochlea?",
    "seeds": [
      "Incomplete partition of the cochlea"
    ],
    "gold_answer": "Cochlear malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10574",
    "question": "What is associated with Neurodevelopmental disorder with visual defects and brain anomalies?",
    "seeds": [
      "Neurodevelopmental disorder with visual defects and brain anomalies"
    ],
    "gold_answer": "Abnormal cerebral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10575",
    "question": "What is associated with Cerebral infarct?",
    "seeds": [
      "Cerebral infarct"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10576",
    "question": "What is associated with Helicobacter pylori infection, susceptibility to?",
    "seeds": [
      "Helicobacter pylori infection, susceptibility to"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10577",
    "question": "What is associated with Ductal bile plugs?",
    "seeds": [
      "Ductal bile plugs"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10578",
    "question": "What is associated with Anti-GlyR antibody?",
    "seeds": [
      "Anti-GlyR antibody"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10579",
    "question": "What is associated with Migraine with or without aura, susceptibility to, 6?",
    "seeds": [
      "Migraine with or without aura, susceptibility to, 6"
    ],
    "gold_answer": "Sensory hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10580",
    "question": "What is associated with Congenital bullous ichthyosiform erythroderma?",
    "seeds": [
      "Congenital bullous ichthyosiform erythroderma"
    ],
    "gold_answer": "Ichthyosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10581",
    "question": "What is associated with Buerger disease?",
    "seeds": [
      "Buerger disease"
    ],
    "gold_answer": "Abnormality of skin adnexa physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10582",
    "question": "What phenotype is associated with Albinism-deafness syndrome?",
    "seeds": [
      "Albinism-deafness syndrome"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10583",
    "question": "What phenotype is associated with Congenital pulmonary lymphangiectasia?",
    "seeds": [
      "Congenital pulmonary lymphangiectasia"
    ],
    "gold_answer": "Capillary leak",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10584",
    "question": "What phenotype is associated with Macular dystrophy, retinal, 1, north Carolina type?",
    "seeds": [
      "Macular dystrophy, retinal, 1, north Carolina type"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10585",
    "question": "What is associated with Compression-fractured thoracic vertebra?",
    "seeds": [
      "Compression-fractured thoracic vertebra"
    ],
    "gold_answer": "Fractured thoracic vertebra",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10586",
    "question": "What phenotype is associated with Isolated osteopoikilosis?",
    "seeds": [
      "Isolated osteopoikilosis"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10587",
    "question": "What is associated with Increased muscle fatiguability?",
    "seeds": [
      "Increased muscle fatiguability"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10588",
    "question": "What is associated with Sclerosis of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Sclerosis of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10589",
    "question": "What is associated with Upper extremity hypokinesia?",
    "seeds": [
      "Upper extremity hypokinesia"
    ],
    "gold_answer": "Hypokinesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10590",
    "question": "What is associated with Developmental and epileptic encephalopathy 106?",
    "seeds": [
      "Developmental and epileptic encephalopathy 106"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10591",
    "question": "What is associated with Superiorly displaced ears?",
    "seeds": [
      "Superiorly displaced ears"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10592",
    "question": "What is associated with High intestinal obstruction?",
    "seeds": [
      "High intestinal obstruction"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10593",
    "question": "What is associated with Dilated vas deferens?",
    "seeds": [
      "Dilated vas deferens"
    ],
    "gold_answer": "Abnormal vas deferens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10594",
    "question": "What is associated with Elevated circulating hexanoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating hexanoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating C6 acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10595",
    "question": "What phenotype is associated with Proximal 16p11.2 microdeletion syndrome?",
    "seeds": [
      "Proximal 16p11.2 microdeletion syndrome"
    ],
    "gold_answer": "Cranial nerve paralysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10596",
    "question": "What is associated with ACROOSTEOLYSIS?",
    "seeds": [
      "ACROOSTEOLYSIS"
    ],
    "gold_answer": "Osteolytic defects of the hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10597",
    "question": "What is associated with Long-chain dicarboxylic aciduria?",
    "seeds": [
      "Long-chain dicarboxylic aciduria"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10598",
    "question": "What is associated with Reduced CD95-induced lymphocyte apoptosis?",
    "seeds": [
      "Reduced CD95-induced lymphocyte apoptosis"
    ],
    "gold_answer": "Abnormal T cell apoptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10599",
    "question": "What is associated with Maceration?",
    "seeds": [
      "Maceration"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10600",
    "question": "What is associated with EEG with central sharp slow waves?",
    "seeds": [
      "EEG with central sharp slow waves"
    ],
    "gold_answer": "EEG with focal sharp slow waves",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10601",
    "question": "What is associated with Part-solid pulmonary nodule?",
    "seeds": [
      "Part-solid pulmonary nodule"
    ],
    "gold_answer": "Pulmonary nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10602",
    "question": "What is associated with Incessant infant ventricular tachycardia?",
    "seeds": [
      "Incessant infant ventricular tachycardia"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10603",
    "question": "What phenotype is associated with Mast cell sarcoma?",
    "seeds": [
      "Mast cell sarcoma"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10604",
    "question": "What is associated with Femoral bowing present at birth, straightening with time?",
    "seeds": [
      "Femoral bowing present at birth, straightening with time"
    ],
    "gold_answer": "Bowing of the long bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10605",
    "question": "What is associated with Eclampsia?",
    "seeds": [
      "Eclampsia"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10606",
    "question": "What is associated with Spondylocostal dysostosis 6, autosomal recessive?",
    "seeds": [
      "Spondylocostal dysostosis 6, autosomal recessive"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10607",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 46?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 46"
    ],
    "gold_answer": "Abnormal activity of mitochondrial respiratory chain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10608",
    "question": "What is associated with Elevated circulating vitamin B12 concentration?",
    "seeds": [
      "Elevated circulating vitamin B12 concentration"
    ],
    "gold_answer": "Abnormal circulating vitamin B12 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10609",
    "question": "What is associated with Abnormal double-negative T cell proportion?",
    "seeds": [
      "Abnormal double-negative T cell proportion"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10610",
    "question": "What phenotype is associated with Deafness, autosomal recessive 70?",
    "seeds": [
      "Deafness, autosomal recessive 70"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10611",
    "question": "What is associated with Spinocerebellar ataxia type 19/22?",
    "seeds": [
      "Spinocerebellar ataxia type 19/22"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10612",
    "question": "What is associated with Polyglucosan body myopathy type 2?",
    "seeds": [
      "Polyglucosan body myopathy type 2"
    ],
    "gold_answer": "GYG1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_10613",
    "question": "What is associated with Loss of gluteal subcutaneous adipose tissue?",
    "seeds": [
      "Loss of gluteal subcutaneous adipose tissue"
    ],
    "gold_answer": "Decreased adipose tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10614",
    "question": "What is associated with Nephronophthisis 4?",
    "seeds": [
      "Nephronophthisis 4"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10615",
    "question": "What is associated with Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism?",
    "seeds": [
      "Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10616",
    "question": "What is associated with Pleural cobblestoning?",
    "seeds": [
      "Pleural cobblestoning"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10617",
    "question": "What is associated with Fractured proximal phalanx of manual digit 1?",
    "seeds": [
      "Fractured proximal phalanx of manual digit 1"
    ],
    "gold_answer": "Fractured finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10618",
    "question": "What phenotype is associated with Ichthyosis-alopecia-eclabion-ectropion-intellectual disability syndrome?",
    "seeds": [
      "Ichthyosis-alopecia-eclabion-ectropion-intellectual disability syndrome"
    ],
    "gold_answer": "Inflammation of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10619",
    "question": "What is associated with Bracket epiphysis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Bracket epiphysis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10620",
    "question": "What is associated with Globe retraction and deviation on abduction?",
    "seeds": [
      "Globe retraction and deviation on abduction"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10621",
    "question": "What is associated with True anophthalmia?",
    "seeds": [
      "True anophthalmia"
    ],
    "gold_answer": "Abnormality of globe size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10622",
    "question": "What is associated with Abnormal circulating ferritin concentration?",
    "seeds": [
      "Abnormal circulating ferritin concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10623",
    "question": "What is associated with Aplasia/Hypoplasia of the proximal phalanx of the thumb?",
    "seeds": [
      "Aplasia/Hypoplasia of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10624",
    "question": "What is associated with Increased hepatitis A virus antibody level?",
    "seeds": [
      "Increased hepatitis A virus antibody level"
    ],
    "gold_answer": "Increased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10625",
    "question": "What is associated with Reduced intrathoracic adipose tissue?",
    "seeds": [
      "Reduced intrathoracic adipose tissue"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10626",
    "question": "What is associated with Multinucleated neuron?",
    "seeds": [
      "Multinucleated neuron"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10627",
    "question": "What is associated with Hyperinsulinemic hypoglycemia, familial, 2?",
    "seeds": [
      "Hyperinsulinemic hypoglycemia, familial, 2"
    ],
    "gold_answer": "Abnormal pancreas morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10628",
    "question": "What phenotype is associated with Spastic paraplegia 29, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 29, autosomal dominant"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10629",
    "question": "What is associated with Abnormal myelination?",
    "seeds": [
      "Abnormal myelination"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10630",
    "question": "What is associated with Progressive truncal ataxia?",
    "seeds": [
      "Progressive truncal ataxia"
    ],
    "gold_answer": "Truncal ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10631",
    "question": "What is associated with Retinopathy of prematurity stage 3?",
    "seeds": [
      "Retinopathy of prematurity stage 3"
    ],
    "gold_answer": "Retinopathy of prematurity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10632",
    "question": "What is associated with Abnormal circulating heparan sulfate level?",
    "seeds": [
      "Abnormal circulating heparan sulfate level"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10633",
    "question": "What is associated with Torus palatinus?",
    "seeds": [
      "Torus palatinus"
    ],
    "gold_answer": "Abnormal hard palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10634",
    "question": "What is associated with Posttussive emesis?",
    "seeds": [
      "Posttussive emesis"
    ],
    "gold_answer": "Vomiting",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10635",
    "question": "What is associated with Branchial sinus?",
    "seeds": [
      "Branchial sinus"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10636",
    "question": "What is associated with Spastic paraplegia-precocious puberty syndrome?",
    "seeds": [
      "Spastic paraplegia-precocious puberty syndrome"
    ],
    "gold_answer": "Paraplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10637",
    "question": "What is associated with Irregular, rachitic-like metaphyses?",
    "seeds": [
      "Irregular, rachitic-like metaphyses"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10638",
    "question": "What is associated with Low tetrahydrocortisol (THF) plus 5-alpha-THF/tetrahydrocortisone (THE) ratio?",
    "seeds": [
      "Low tetrahydrocortisol (THF) plus 5-alpha-THF/tetrahydrocortisone (THE) ratio"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10639",
    "question": "What is associated with Renal cell carcinoma, xp11-associated?",
    "seeds": [
      "Renal cell carcinoma, xp11-associated"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10640",
    "question": "What is associated with Excessive eructation?",
    "seeds": [
      "Excessive eructation"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10641",
    "question": "What is associated with Decreased alveolar volume?",
    "seeds": [
      "Decreased alveolar volume"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10642",
    "question": "What is associated with Horizontal ribs?",
    "seeds": [
      "Horizontal ribs"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10643",
    "question": "What is associated with Inferiorly positioned umbilicus?",
    "seeds": [
      "Inferiorly positioned umbilicus"
    ],
    "gold_answer": "Abnormal abdominal wall morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10644",
    "question": "What is associated with Elevated circulating insulin:C-peptide ratio?",
    "seeds": [
      "Elevated circulating insulin:C-peptide ratio"
    ],
    "gold_answer": "Abnormal circulating insulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10645",
    "question": "What is associated with Broad femoral head?",
    "seeds": [
      "Broad femoral head"
    ],
    "gold_answer": "Abnormal femoral neck/head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10646",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 60?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 60"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10647",
    "question": "What is associated with Periostosis?",
    "seeds": [
      "Periostosis"
    ],
    "gold_answer": "Abnormal periosteum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10648",
    "question": "What is associated with Abnormal hand cortical bone morphology?",
    "seeds": [
      "Abnormal hand cortical bone morphology"
    ],
    "gold_answer": "Abnormal cortical bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10649",
    "question": "What is associated with Cerebroretinal microangiopathy with calcifications and cysts 2?",
    "seeds": [
      "Cerebroretinal microangiopathy with calcifications and cysts 2"
    ],
    "gold_answer": "Increased blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10650",
    "question": "What is associated with Atrial fibrillation, familial, 11?",
    "seeds": [
      "Atrial fibrillation, familial, 11"
    ],
    "gold_answer": "Abnormal left ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10651",
    "question": "What phenotype is associated with Polydactyly, postaxial, type A6?",
    "seeds": [
      "Polydactyly, postaxial, type A6"
    ],
    "gold_answer": "Abnormal sweat gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10652",
    "question": "What is associated with Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality?",
    "seeds": [
      "Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10653",
    "question": "What is associated with Reduced plantar creases?",
    "seeds": [
      "Reduced plantar creases"
    ],
    "gold_answer": "Abnormality of the plantar skin of foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10654",
    "question": "What is associated with Tongue nodules?",
    "seeds": [
      "Tongue nodules"
    ],
    "gold_answer": "Abnormal tongue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10655",
    "question": "What phenotype is associated with Proximal 3rd toe symphalangism?",
    "seeds": [
      "Proximal 3rd toe symphalangism"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10656",
    "question": "What phenotype is associated with Cole-Carpenter syndrome?",
    "seeds": [
      "Cole-Carpenter syndrome"
    ],
    "gold_answer": "Midface retrusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10657",
    "question": "What is associated with Severe periodontitis?",
    "seeds": [
      "Severe periodontitis"
    ],
    "gold_answer": "Periodontitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10658",
    "question": "What is associated with Elevated urine L-alloisoleucine level?",
    "seeds": [
      "Elevated urine L-alloisoleucine level"
    ],
    "gold_answer": "Increased urine proteinogenic amino acid derivative level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10659",
    "question": "What is associated with Chromosome 14q11-q22 deletion syndrome?",
    "seeds": [
      "Chromosome 14q11-q22 deletion syndrome"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10660",
    "question": "What is associated with Pain on the lateral aspect of the foot?",
    "seeds": [
      "Pain on the lateral aspect of the foot"
    ],
    "gold_answer": "Lower limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10661",
    "question": "What is associated with Extrasystoles-short stature-hyperpigmentation-microcephaly syndrome?",
    "seeds": [
      "Extrasystoles-short stature-hyperpigmentation-microcephaly syndrome"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10662",
    "question": "What is associated with Dysharmonic maturation of the hand bones?",
    "seeds": [
      "Dysharmonic maturation of the hand bones"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10663",
    "question": "What is associated with Long ulna?",
    "seeds": [
      "Long ulna"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10664",
    "question": "What is associated with Autosomal dominant spastic ataxia type 1?",
    "seeds": [
      "Autosomal dominant spastic ataxia type 1"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10665",
    "question": "What is associated with Decreased erythrocyte UDP glucose-4-epimerase concentration?",
    "seeds": [
      "Decreased erythrocyte UDP glucose-4-epimerase concentration"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10666",
    "question": "What is associated with Abnormal distal humeral epiphysis morphology?",
    "seeds": [
      "Abnormal distal humeral epiphysis morphology"
    ],
    "gold_answer": "Abnormal elbow epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10667",
    "question": "What is associated with Euthyroid multinodular goiter?",
    "seeds": [
      "Euthyroid multinodular goiter"
    ],
    "gold_answer": "Abnormal thyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10668",
    "question": "What is associated with Elevated circulating acetylcarnitine concentration?",
    "seeds": [
      "Elevated circulating acetylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10669",
    "question": "What is associated with Fibular aplasia-complex brachydactyly syndrome?",
    "seeds": [
      "Fibular aplasia-complex brachydactyly syndrome"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10670",
    "question": "What is associated with Non-motor seizure?",
    "seeds": [
      "Non-motor seizure"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10671",
    "question": "What is associated with Lymphedema, hereditary, II?",
    "seeds": [
      "Lymphedema, hereditary, II"
    ],
    "gold_answer": "Craniofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10672",
    "question": "What is associated with Asymmetrical distribution of flash visual evoked potentials?",
    "seeds": [
      "Asymmetrical distribution of flash visual evoked potentials"
    ],
    "gold_answer": "Abnormal flash visual evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10673",
    "question": "What is associated with Systemic autoinflammation?",
    "seeds": [
      "Systemic autoinflammation"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10674",
    "question": "What is associated with Elevated sweat chloride?",
    "seeds": [
      "Elevated sweat chloride"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10675",
    "question": "What is associated with Recurrent sinusitis?",
    "seeds": [
      "Recurrent sinusitis"
    ],
    "gold_answer": "Sinusitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10676",
    "question": "What is associated with Distally placed thumb?",
    "seeds": [
      "Distally placed thumb"
    ],
    "gold_answer": "Deviation of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10677",
    "question": "What phenotype is associated with Osteosclerosis-developmental delay-craniosynostosis syndrome?",
    "seeds": [
      "Osteosclerosis-developmental delay-craniosynostosis syndrome"
    ],
    "gold_answer": "High forehead",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10678",
    "question": "What is associated with Jumping?",
    "seeds": [
      "Jumping"
    ],
    "gold_answer": "Sensory behavioral abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10679",
    "question": "What is associated with Abnormal natural killer cell morphology?",
    "seeds": [
      "Abnormal natural killer cell morphology"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10680",
    "question": "What is associated with Ductus venosus agenesis with intrahepatic drainage?",
    "seeds": [
      "Ductus venosus agenesis with intrahepatic drainage"
    ],
    "gold_answer": "Ductus venosus agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10681",
    "question": "What is associated with Positive talar tilt test?",
    "seeds": [
      "Positive talar tilt test"
    ],
    "gold_answer": "Abnormality of the ankle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10682",
    "question": "What is associated with Absence of the third cerebral ventricle?",
    "seeds": [
      "Absence of the third cerebral ventricle"
    ],
    "gold_answer": "Abnormal third ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10683",
    "question": "What is associated with Abnormal atrioventricular valve morphology?",
    "seeds": [
      "Abnormal atrioventricular valve morphology"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10684",
    "question": "What is associated with Periodic paralysis?",
    "seeds": [
      "Periodic paralysis"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10685",
    "question": "What is associated with Cortical radial artery medial hypertrophy?",
    "seeds": [
      "Cortical radial artery medial hypertrophy"
    ],
    "gold_answer": "Abnormal cortical radial artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10686",
    "question": "What is associated with Cerebral ventricular adhesions?",
    "seeds": [
      "Cerebral ventricular adhesions"
    ],
    "gold_answer": "Abnormal cerebral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10687",
    "question": "What is associated with Morbilliform?",
    "seeds": [
      "Morbilliform"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10688",
    "question": "What is associated with Orthokeratosis?",
    "seeds": [
      "Orthokeratosis"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10689",
    "question": "What is associated with Charcot-Marie-Tooth disease, type 4B3?",
    "seeds": [
      "Charcot-Marie-Tooth disease, type 4B3"
    ],
    "gold_answer": "Distal muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10690",
    "question": "What phenotype is associated with Ulnar-mammary syndrome?",
    "seeds": [
      "Ulnar-mammary syndrome"
    ],
    "gold_answer": "Obesity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10691",
    "question": "What is associated with Retinal phlebitis?",
    "seeds": [
      "Retinal phlebitis"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10692",
    "question": "What is associated with Pericentral scotoma?",
    "seeds": [
      "Pericentral scotoma"
    ],
    "gold_answer": "Scotoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10693",
    "question": "What is associated with Cholesteatoma?",
    "seeds": [
      "Cholesteatoma"
    ],
    "gold_answer": "Abnormal middle ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10694",
    "question": "What is associated with Cardiac teratoma?",
    "seeds": [
      "Cardiac teratoma"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10695",
    "question": "What is associated with Congenital alopecia totalis?",
    "seeds": [
      "Congenital alopecia totalis"
    ],
    "gold_answer": "Alopecia totalis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10696",
    "question": "What is associated with Posterior staphyloma?",
    "seeds": [
      "Posterior staphyloma"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10697",
    "question": "What is associated with Ameliorated by vitamin B12?",
    "seeds": [
      "Ameliorated by vitamin B12"
    ],
    "gold_answer": "Ameliorated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10698",
    "question": "What is associated with Metacarpal fracture?",
    "seeds": [
      "Metacarpal fracture"
    ],
    "gold_answer": "Fractured hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10699",
    "question": "What phenotype is associated with DEGCAGS syndrome?",
    "seeds": [
      "DEGCAGS syndrome"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10700",
    "question": "What is associated with Amyotrophic lateral sclerosis 21?",
    "seeds": [
      "Amyotrophic lateral sclerosis 21"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10701",
    "question": "What is associated with Decreased circulating gonadotropin concentration?",
    "seeds": [
      "Decreased circulating gonadotropin concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10702",
    "question": "What is associated with Unilateral radial aplasia?",
    "seeds": [
      "Unilateral radial aplasia"
    ],
    "gold_answer": "Absent radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10703",
    "question": "What is associated with Ungual fibroma?",
    "seeds": [
      "Ungual fibroma"
    ],
    "gold_answer": "Sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10704",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 5A?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 5A"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10705",
    "question": "What phenotype is associated with HJV or HAMP-related hemochromatosis?",
    "seeds": [
      "HJV or HAMP-related hemochromatosis"
    ],
    "gold_answer": "Elevated circulating hepatic transaminase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10706",
    "question": "What is associated with Delayed distal femoral epiphyseal ossification?",
    "seeds": [
      "Delayed distal femoral epiphyseal ossification"
    ],
    "gold_answer": "Abnormality of the distal femoral epiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10707",
    "question": "What is associated with Aplasia/Hypoplasia affecting the anterior segment of the eye?",
    "seeds": [
      "Aplasia/Hypoplasia affecting the anterior segment of the eye"
    ],
    "gold_answer": "Ocular anterior segment dysgenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10708",
    "question": "What is associated with Allergic rhinitis?",
    "seeds": [
      "Allergic rhinitis"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10709",
    "question": "What is associated with Facial paresis, hereditary congenital, 1?",
    "seeds": [
      "Facial paresis, hereditary congenital, 1"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10710",
    "question": "What is associated with Abnormal circulating beta-CTX concentration?",
    "seeds": [
      "Abnormal circulating beta-CTX concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10711",
    "question": "What is associated with X-linked dystonia-parkinsonism?",
    "seeds": [
      "X-linked dystonia-parkinsonism"
    ],
    "gold_answer": "Abnormal eyelid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10712",
    "question": "What is associated with Molar tooth sign on MRI?",
    "seeds": [
      "Molar tooth sign on MRI"
    ],
    "gold_answer": "Abnormal midbrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10713",
    "question": "What is associated with Osteochondrosis of the tarsal bone?",
    "seeds": [
      "Osteochondrosis of the tarsal bone"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10714",
    "question": "What is associated with Coronary artery disease, autosomal dominant 2?",
    "seeds": [
      "Coronary artery disease, autosomal dominant 2"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10715",
    "question": "What phenotype is associated with Dentinogenesis imperfecta?",
    "seeds": [
      "Dentinogenesis imperfecta"
    ],
    "gold_answer": "Abnormality of the dental pulp",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10716",
    "question": "What is associated with Leukonychia totalis?",
    "seeds": [
      "Leukonychia totalis"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10717",
    "question": "What phenotype is associated with Posterior polymorphous corneal dystrophy?",
    "seeds": [
      "Posterior polymorphous corneal dystrophy"
    ],
    "gold_answer": "Ocular pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10718",
    "question": "What is associated with Li-Fraumeni syndrome?",
    "seeds": [
      "Li-Fraumeni syndrome"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10719",
    "question": "What is associated with Goiter, multinodular 2?",
    "seeds": [
      "Goiter, multinodular 2"
    ],
    "gold_answer": "Goiter",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10720",
    "question": "What is associated with Agoraphobia?",
    "seeds": [
      "Agoraphobia"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10721",
    "question": "What phenotype is associated with Infantile Krabbe disease?",
    "seeds": [
      "Infantile Krabbe disease"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10722",
    "question": "What is associated with Urinary bladder neurofibroma?",
    "seeds": [
      "Urinary bladder neurofibroma"
    ],
    "gold_answer": "Urinary tract neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10723",
    "question": "What is associated with Thymic cyst?",
    "seeds": [
      "Thymic cyst"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10724",
    "question": "What is associated with Abnormal left ventricular ejection fraction?",
    "seeds": [
      "Abnormal left ventricular ejection fraction"
    ],
    "gold_answer": "Abnormal cardiac ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10725",
    "question": "What is associated with Intellectual developmental disorder, X-linked 84?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 84"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10726",
    "question": "What is associated with Polydactyly affecting the 4th finger?",
    "seeds": [
      "Polydactyly affecting the 4th finger"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10727",
    "question": "What phenotype is associated with Pouchitis?",
    "seeds": [
      "Pouchitis"
    ],
    "gold_answer": "Abdominal cramps",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10728",
    "question": "What is associated with Hypoplasia of the fallopian tube?",
    "seeds": [
      "Hypoplasia of the fallopian tube"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the fallopian tube",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10729",
    "question": "What is associated with Sleep-related hypermotor epilepsy?",
    "seeds": [
      "Sleep-related hypermotor epilepsy"
    ],
    "gold_answer": "Abnormal psychotic pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10730",
    "question": "What is associated with Avulsion fractured epiphysis of femur?",
    "seeds": [
      "Avulsion fractured epiphysis of femur"
    ],
    "gold_answer": "Fractured epiphysis of femur",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10731",
    "question": "What phenotype is associated with Myopathy, distal 3?",
    "seeds": [
      "Myopathy, distal 3"
    ],
    "gold_answer": "Muscular dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10732",
    "question": "What phenotype is associated with IgG4-related retroperitoneal fibrosis?",
    "seeds": [
      "IgG4-related retroperitoneal fibrosis"
    ],
    "gold_answer": "Elevated circulating creatinine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10733",
    "question": "What is associated with Cone-shaped epiphyses of the 5th toe?",
    "seeds": [
      "Cone-shaped epiphyses of the 5th toe"
    ],
    "gold_answer": "Cone-shaped epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10734",
    "question": "What is associated with Shaheen syndrome?",
    "seeds": [
      "Shaheen syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10735",
    "question": "What is associated with Radial artery aplasia?",
    "seeds": [
      "Radial artery aplasia"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10736",
    "question": "What is associated with Mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency?",
    "seeds": [
      "Mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency"
    ],
    "gold_answer": "RORC",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10737",
    "question": "What is associated with Anti-Septin-5 antibody?",
    "seeds": [
      "Anti-Septin-5 antibody"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10738",
    "question": "What phenotype is associated with Congenital ichthyosis-microcephalus-tetraplegia syndrome?",
    "seeds": [
      "Congenital ichthyosis-microcephalus-tetraplegia syndrome"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10739",
    "question": "What is associated with Abnormal DLCO?",
    "seeds": [
      "Abnormal DLCO"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10740",
    "question": "What is associated with Pseudohypoaldosteronism, type IIC?",
    "seeds": [
      "Pseudohypoaldosteronism, type IIC"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10741",
    "question": "What is associated with Normal interictal EEG?",
    "seeds": [
      "Normal interictal EEG"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10742",
    "question": "What is associated with Cerebral ischemia?",
    "seeds": [
      "Cerebral ischemia"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10743",
    "question": "What is associated with Focal aware autonomic seizure with urge to urinate/defecate?",
    "seeds": [
      "Focal aware autonomic seizure with urge to urinate/defecate"
    ],
    "gold_answer": "Focal aware autonomic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10744",
    "question": "What is associated with Testes, rudimentary?",
    "seeds": [
      "Testes, rudimentary"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10745",
    "question": "What is associated with Earlobes, thickened, with conductive deafness from incudostapedialabnormalities?",
    "seeds": [
      "Earlobes, thickened, with conductive deafness from incudostapedialabnormalities"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the mandible",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10746",
    "question": "What is associated with Isolated Klippel-Feil syndrome?",
    "seeds": [
      "Isolated Klippel-Feil syndrome"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10747",
    "question": "What phenotype is associated with Atrioventricular septal defect, partial, with heterotaxy syndrome?",
    "seeds": [
      "Atrioventricular septal defect, partial, with heterotaxy syndrome"
    ],
    "gold_answer": "Intestinal malrotation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10748",
    "question": "What is associated with Abnormal CD69 upregulation upon TCR activation?",
    "seeds": [
      "Abnormal CD69 upregulation upon TCR activation"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10749",
    "question": "What phenotype is associated with Fanconi renotubular syndrome 1?",
    "seeds": [
      "Fanconi renotubular syndrome 1"
    ],
    "gold_answer": "Metabolic acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10750",
    "question": "What is associated with Diffuse cerebral atrophy?",
    "seeds": [
      "Diffuse cerebral atrophy"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10751",
    "question": "What is associated with Hemolytic anemia with thermal sensitivity of red cells?",
    "seeds": [
      "Hemolytic anemia with thermal sensitivity of red cells"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10752",
    "question": "What is associated with Dislocated radial head?",
    "seeds": [
      "Dislocated radial head"
    ],
    "gold_answer": "Abnormal elbow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10753",
    "question": "What is associated with Laryngeal papilloma?",
    "seeds": [
      "Laryngeal papilloma"
    ],
    "gold_answer": "Neoplasm of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10754",
    "question": "What is associated with Neuronopathy, distal hereditary motor, type X?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, type X"
    ],
    "gold_answer": "Abnormality of the musculature of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10755",
    "question": "What is associated with Parotid gland adenocarcinoma?",
    "seeds": [
      "Parotid gland adenocarcinoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10756",
    "question": "What is associated with Sebaceous gland carcinoma?",
    "seeds": [
      "Sebaceous gland carcinoma"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10757",
    "question": "What phenotype is associated with Deafness-Oligodontia syndrome?",
    "seeds": [
      "Deafness-Oligodontia syndrome"
    ],
    "gold_answer": "Eclabion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10758",
    "question": "What is associated with Reduced muscle 2,4-dienoyl-CoA reductase activity?",
    "seeds": [
      "Reduced muscle 2,4-dienoyl-CoA reductase activity"
    ],
    "gold_answer": "Abnormal enzyme activity in muscle tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10759",
    "question": "What phenotype is associated with Dandy-Walker syndrome?",
    "seeds": [
      "Dandy-Walker syndrome"
    ],
    "gold_answer": "Partial absence of cerebellar vermis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10760",
    "question": "What phenotype is associated with Mandibulofacial dysostosis-microcephaly syndrome?",
    "seeds": [
      "Mandibulofacial dysostosis-microcephaly syndrome"
    ],
    "gold_answer": "Choanal atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10761",
    "question": "What is associated with Abnormal circulating progesterone level?",
    "seeds": [
      "Abnormal circulating progesterone level"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10762",
    "question": "What is associated with Positive urine cocaine test?",
    "seeds": [
      "Positive urine cocaine test"
    ],
    "gold_answer": "Presence of xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10763",
    "question": "What is associated with Ulnar/fibula ray defect-brachydactyly syndrome?",
    "seeds": [
      "Ulnar/fibula ray defect-brachydactyly syndrome"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10764",
    "question": "What is associated with Reduced residual volume?",
    "seeds": [
      "Reduced residual volume"
    ],
    "gold_answer": "Abnormal residual volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10765",
    "question": "What is associated with Congenital amegakaryocytic thrombocytopenia?",
    "seeds": [
      "Congenital amegakaryocytic thrombocytopenia"
    ],
    "gold_answer": "Nevus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10766",
    "question": "What is associated with Carney-Stratakis syndrome?",
    "seeds": [
      "Carney-Stratakis syndrome"
    ],
    "gold_answer": "SDHC",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_10767",
    "question": "What phenotype is associated with Orofaciodigital syndrome XI?",
    "seeds": [
      "Orofaciodigital syndrome XI"
    ],
    "gold_answer": "Esophagitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10768",
    "question": "What is associated with Chromosome 9P deletion syndrome?",
    "seeds": [
      "Chromosome 9P deletion syndrome"
    ],
    "gold_answer": "Abnormal neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10769",
    "question": "What is associated with Inner retinal layer loss on macular OCT?",
    "seeds": [
      "Inner retinal layer loss on macular OCT"
    ],
    "gold_answer": "Abnormal optical coherence tomography",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10770",
    "question": "What is associated with Partial duplication of thumb phalanx?",
    "seeds": [
      "Partial duplication of thumb phalanx"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10771",
    "question": "What phenotype is associated with Spastic paraplegia 26, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 26, autosomal recessive"
    ],
    "gold_answer": "Dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10772",
    "question": "What is associated with Grade V vesicoureteral reflux?",
    "seeds": [
      "Grade V vesicoureteral reflux"
    ],
    "gold_answer": "High-grade vesicoureteral reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10773",
    "question": "What is associated with Fragile X-associated primary ovarian insufficiency?",
    "seeds": [
      "Fragile X-associated primary ovarian insufficiency"
    ],
    "gold_answer": "FMR1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10774",
    "question": "What is associated with Nipple tenderness?",
    "seeds": [
      "Nipple tenderness"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10775",
    "question": "What is associated with Epileptic aura?",
    "seeds": [
      "Epileptic aura"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10776",
    "question": "What is associated with C1-C2 subluxation?",
    "seeds": [
      "C1-C2 subluxation"
    ],
    "gold_answer": "C1-C2 vertebral abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10777",
    "question": "What is associated with Dysmetria?",
    "seeds": [
      "Dysmetria"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10778",
    "question": "What is associated with Weakness of muscles of respiration?",
    "seeds": [
      "Weakness of muscles of respiration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10779",
    "question": "What is associated with Elevated brain guanidinoacetate level by MRS?",
    "seeds": [
      "Elevated brain guanidinoacetate level by MRS"
    ],
    "gold_answer": "Abnormal metabolic brain imaging by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10780",
    "question": "What is associated with Saddle-back type ST segment elevation?",
    "seeds": [
      "Saddle-back type ST segment elevation"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10781",
    "question": "What is associated with Decreased Th17 T cell proportion?",
    "seeds": [
      "Decreased Th17 T cell proportion"
    ],
    "gold_answer": "Abnormal T cell physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10782",
    "question": "What phenotype is associated with Microvillus inclusion disease?",
    "seeds": [
      "Microvillus inclusion disease"
    ],
    "gold_answer": "Diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10783",
    "question": "What is associated with Absent sternal ossification?",
    "seeds": [
      "Absent sternal ossification"
    ],
    "gold_answer": "Abnormal sternum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10784",
    "question": "What is associated with Acatalasemia?",
    "seeds": [
      "Acatalasemia"
    ],
    "gold_answer": "Abnormality of the upper respiratory tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10785",
    "question": "What is associated with Abnormal middle ear reflexes?",
    "seeds": [
      "Abnormal middle ear reflexes"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10786",
    "question": "What is associated with Accessory carpal bones?",
    "seeds": [
      "Accessory carpal bones"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10787",
    "question": "What is associated with Midperipheral?",
    "seeds": [
      "Midperipheral"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10788",
    "question": "What is associated with EEG with localized low amplitude activity?",
    "seeds": [
      "EEG with localized low amplitude activity"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10789",
    "question": "What is associated with Tooth ankylosis?",
    "seeds": [
      "Tooth ankylosis"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10790",
    "question": "What is associated with Ivory epiphysis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Ivory epiphysis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Ivory epiphyses of the distal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10791",
    "question": "What is associated with Alpha-N-acetylgalactosaminidase deficiency type 2?",
    "seeds": [
      "Alpha-N-acetylgalactosaminidase deficiency type 2"
    ],
    "gold_answer": "Abnormal corneal stroma morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10792",
    "question": "What is associated with Decreased urinary potassium?",
    "seeds": [
      "Decreased urinary potassium"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10793",
    "question": "What phenotype is associated with Cerebrocostomandibular syndrome?",
    "seeds": [
      "Cerebrocostomandibular syndrome"
    ],
    "gold_answer": "Anteriorly placed anus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10794",
    "question": "What phenotype is associated with Cervical vertebral dysplasia?",
    "seeds": [
      "Cervical vertebral dysplasia"
    ],
    "gold_answer": "Cervical vertebral facet hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10795",
    "question": "What is associated with Increased adipose tissue?",
    "seeds": [
      "Increased adipose tissue"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10796",
    "question": "What is associated with Increased female libido?",
    "seeds": [
      "Increased female libido"
    ],
    "gold_answer": "Abnormal sexual behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10797",
    "question": "What is associated with Hydroxyprolinemia?",
    "seeds": [
      "Hydroxyprolinemia"
    ],
    "gold_answer": "Abnormal circulating proline concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10798",
    "question": "What is associated with Abnormal nasolabial region morphology?",
    "seeds": [
      "Abnormal nasolabial region morphology"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10799",
    "question": "What is associated with Decreased circulating vitamin D concentration?",
    "seeds": [
      "Decreased circulating vitamin D concentration"
    ],
    "gold_answer": "Abnormal metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10800",
    "question": "What phenotype is associated with Hennekam lymphangiectasia-lymphedema syndrome?",
    "seeds": [
      "Hennekam lymphangiectasia-lymphedema syndrome"
    ],
    "gold_answer": "Talipes equinovarus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10801",
    "question": "What is associated with Increased urinary taurine?",
    "seeds": [
      "Increased urinary taurine"
    ],
    "gold_answer": "Increased urine proteinogenic amino acid derivative level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10802",
    "question": "What is associated with Taurodontia?",
    "seeds": [
      "Taurodontia"
    ],
    "gold_answer": "Abnormal dental morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10803",
    "question": "What is associated with Parkinson disease 6, autosomal recessive early-onset?",
    "seeds": [
      "Parkinson disease 6, autosomal recessive early-onset"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10804",
    "question": "What is associated with Axenfeld-rieger syndrome, type 2?",
    "seeds": [
      "Axenfeld-rieger syndrome, type 2"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10805",
    "question": "What phenotype is associated with Solitary fibrous tumor?",
    "seeds": [
      "Solitary fibrous tumor"
    ],
    "gold_answer": "Soft tissue neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10806",
    "question": "What is associated with Hypertrichosis terminalis, generalized, with or without gingival hyperplasia?",
    "seeds": [
      "Hypertrichosis terminalis, generalized, with or without gingival hyperplasia"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10807",
    "question": "What is associated with Empty sella turcica?",
    "seeds": [
      "Empty sella turcica"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10808",
    "question": "What is associated with Increased RBC distribution width?",
    "seeds": [
      "Increased RBC distribution width"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10809",
    "question": "What phenotype is associated with Cardiomyopathy, familial restrictive, 6?",
    "seeds": [
      "Cardiomyopathy, familial restrictive, 6"
    ],
    "gold_answer": "Pulmonic regurgitation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10810",
    "question": "What is associated with Delayed ability to walk with support?",
    "seeds": [
      "Delayed ability to walk with support"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10811",
    "question": "What is associated with Immunodeficiency 38 with basal ganglia calcification?",
    "seeds": [
      "Immunodeficiency 38 with basal ganglia calcification"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10812",
    "question": "What is associated with Atypical hemolytic uremic syndrome?",
    "seeds": [
      "Atypical hemolytic uremic syndrome"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10813",
    "question": "What is associated with Steatorrhea?",
    "seeds": [
      "Steatorrhea"
    ],
    "gold_answer": "Malabsorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10814",
    "question": "What is associated with Ectopia cordis?",
    "seeds": [
      "Ectopia cordis"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10815",
    "question": "What is associated with High, narrow palate?",
    "seeds": [
      "High, narrow palate"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10816",
    "question": "What is associated with CSF mycobacteria?",
    "seeds": [
      "CSF mycobacteria"
    ],
    "gold_answer": "Bacteria in cerebrospinal fluid",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10817",
    "question": "What is associated with Absent hallux?",
    "seeds": [
      "Absent hallux"
    ],
    "gold_answer": "Absent toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10818",
    "question": "What is associated with Anti-p53 antibody positivity?",
    "seeds": [
      "Anti-p53 antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10819",
    "question": "What is associated with Focal bilateral motor seizure?",
    "seeds": [
      "Focal bilateral motor seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10820",
    "question": "What is associated with Hemorrhage of the eye?",
    "seeds": [
      "Hemorrhage of the eye"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10821",
    "question": "What is associated with Direct antiglobulin test positive for C3d?",
    "seeds": [
      "Direct antiglobulin test positive for C3d"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10822",
    "question": "What is associated with Ventouse delivery?",
    "seeds": [
      "Ventouse delivery"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10823",
    "question": "What is associated with Agenesis of corpus callosum?",
    "seeds": [
      "Agenesis of corpus callosum"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10824",
    "question": "What is associated with Focal aware automatism seizure?",
    "seeds": [
      "Focal aware automatism seizure"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10825",
    "question": "What is associated with Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome?",
    "seeds": [
      "Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10826",
    "question": "What is associated with Spastic paraplegia 73, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 73, autosomal dominant"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10827",
    "question": "What is associated with Chronic atrial and intestinal dysrhythmia?",
    "seeds": [
      "Chronic atrial and intestinal dysrhythmia"
    ],
    "gold_answer": "Abnormal atrioventricular valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10828",
    "question": "What is associated with Anti-lipoprotein lipase autoantibody positivity?",
    "seeds": [
      "Anti-lipoprotein lipase autoantibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10829",
    "question": "What is associated with Anti-von Willebrand factor antibody positivity?",
    "seeds": [
      "Anti-von Willebrand factor antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10830",
    "question": "What is associated with Chromosome 19p13.13 deletion syndrome?",
    "seeds": [
      "Chromosome 19p13.13 deletion syndrome"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10831",
    "question": "What is associated with Bleeding disorder, platelet-type, 15?",
    "seeds": [
      "Bleeding disorder, platelet-type, 15"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10832",
    "question": "What is associated with Aortic dissection?",
    "seeds": [
      "Aortic dissection"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10833",
    "question": "What is associated with Abnormal epiglottis morphology?",
    "seeds": [
      "Abnormal epiglottis morphology"
    ],
    "gold_answer": "Abnormality of the larynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10834",
    "question": "What is associated with Abnormal MHC II cell surface expression?",
    "seeds": [
      "Abnormal MHC II cell surface expression"
    ],
    "gold_answer": "Abnormal MHC surface expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10835",
    "question": "What is associated with Epiphyseal dysplasia, multiple, 1?",
    "seeds": [
      "Epiphyseal dysplasia, multiple, 1"
    ],
    "gold_answer": "Abnormal femoral epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10836",
    "question": "What is associated with Cognitive function 1, social?",
    "seeds": [
      "Cognitive function 1, social"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10837",
    "question": "What is associated with Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction?",
    "seeds": [
      "Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction"
    ],
    "gold_answer": "Constipation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10838",
    "question": "What is associated with Abnormal hemoglobin?",
    "seeds": [
      "Abnormal hemoglobin"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10839",
    "question": "What is associated with Aplasia/Hypoplasia affecting the anterior segment of the eye?",
    "seeds": [
      "Aplasia/Hypoplasia affecting the anterior segment of the eye"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10840",
    "question": "What is associated with Cone-shaped epiphysis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Cone-shaped epiphysis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Cone-shaped epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10841",
    "question": "What is associated with Elevated tissue non-specific alkaline phosphatase?",
    "seeds": [
      "Elevated tissue non-specific alkaline phosphatase"
    ],
    "gold_answer": "Elevated circulating alkaline phosphatase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10842",
    "question": "What is associated with Mild neurosensory hearing impairment?",
    "seeds": [
      "Mild neurosensory hearing impairment"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10843",
    "question": "What is associated with Abnormal circulating porphyrin concentration?",
    "seeds": [
      "Abnormal circulating porphyrin concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10844",
    "question": "What is associated with Premature separation of centromeric heterochromatin?",
    "seeds": [
      "Premature separation of centromeric heterochromatin"
    ],
    "gold_answer": "Abnormality of chromosome segregation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10845",
    "question": "What is associated with Decreased libido?",
    "seeds": [
      "Decreased libido"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10846",
    "question": "What is associated with Perilobar nephroblastomatosis?",
    "seeds": [
      "Perilobar nephroblastomatosis"
    ],
    "gold_answer": "Nephroblastomatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10847",
    "question": "What is associated with NKX6-2-related autosomal recessive hypomyelinating leukodystrophy?",
    "seeds": [
      "NKX6-2-related autosomal recessive hypomyelinating leukodystrophy"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10848",
    "question": "What is associated with Brachyolmia type 1, Toledo type?",
    "seeds": [
      "Brachyolmia type 1, Toledo type"
    ],
    "gold_answer": "Kyphosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10849",
    "question": "What is associated with 3-5 toe syndactyly?",
    "seeds": [
      "3-5 toe syndactyly"
    ],
    "gold_answer": "Toe syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10850",
    "question": "What phenotype is associated with Brachyolmia type 1, Hobaek type?",
    "seeds": [
      "Brachyolmia type 1, Hobaek type"
    ],
    "gold_answer": "Corneal opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10851",
    "question": "What is associated with Abnormal zygomatic bone morphology?",
    "seeds": [
      "Abnormal zygomatic bone morphology"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10852",
    "question": "What is associated with Abnormality of eye movement?",
    "seeds": [
      "Abnormality of eye movement"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10853",
    "question": "What is associated with Alopecia, androgenetic, 1?",
    "seeds": [
      "Alopecia, androgenetic, 1"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10854",
    "question": "What is associated with Symmetrical progressive peripheral demyelination?",
    "seeds": [
      "Symmetrical progressive peripheral demyelination"
    ],
    "gold_answer": "Abnormal peripheral myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10855",
    "question": "What is associated with Abnormal peripheral nerve morphology by anatomical site?",
    "seeds": [
      "Abnormal peripheral nerve morphology by anatomical site"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10856",
    "question": "What is associated with Elevated circulating proinsulin concentration?",
    "seeds": [
      "Elevated circulating proinsulin concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10857",
    "question": "What is associated with Mesomelia-synostoses syndrome?",
    "seeds": [
      "Mesomelia-synostoses syndrome"
    ],
    "gold_answer": "Deviation of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10858",
    "question": "What is associated with Achalasia-Microcephaly syndrome?",
    "seeds": [
      "Achalasia-Microcephaly syndrome"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10859",
    "question": "What phenotype is associated with Specific language impairment 2?",
    "seeds": [
      "Specific language impairment 2"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10860",
    "question": "What is associated with Profound?",
    "seeds": [
      "Profound"
    ],
    "gold_answer": "Severity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10861",
    "question": "What is associated with Dementia, lewy body?",
    "seeds": [
      "Dementia, lewy body"
    ],
    "gold_answer": "Abnormal cognitive process",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10862",
    "question": "What is associated with Bone marrow failure syndrome 3?",
    "seeds": [
      "Bone marrow failure syndrome 3"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10863",
    "question": "What is associated with Absent isohemagglutinin level?",
    "seeds": [
      "Absent isohemagglutinin level"
    ],
    "gold_answer": "Decreased circulating level of specific antibody",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10864",
    "question": "What is associated with Synostosis of joints?",
    "seeds": [
      "Synostosis of joints"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10865",
    "question": "What is associated with Hair-pulling?",
    "seeds": [
      "Hair-pulling"
    ],
    "gold_answer": "Self-injurious behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10866",
    "question": "What is associated with Diminished tissue dihydropteridine reductase activity?",
    "seeds": [
      "Diminished tissue dihydropteridine reductase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10867",
    "question": "What is associated with Pituitary dwarfism?",
    "seeds": [
      "Pituitary dwarfism"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10868",
    "question": "What is associated with Cervical ectropion?",
    "seeds": [
      "Cervical ectropion"
    ],
    "gold_answer": "Abnormality of the uterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10869",
    "question": "What phenotype is associated with SPONDYLOEPIMETAPHYSEAL DYSPLASIA, MICROMELIC?",
    "seeds": [
      "SPONDYLOEPIMETAPHYSEAL DYSPLASIA, MICROMELIC"
    ],
    "gold_answer": "Short neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10870",
    "question": "What is associated with Vitreous haze?",
    "seeds": [
      "Vitreous haze"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10871",
    "question": "What is associated with Increased mean platelet volume?",
    "seeds": [
      "Increased mean platelet volume"
    ],
    "gold_answer": "Abnormal platelet morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10872",
    "question": "What is associated with Vasculitis, lymphocytic, nodular?",
    "seeds": [
      "Vasculitis, lymphocytic, nodular"
    ],
    "gold_answer": "Vasculitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10873",
    "question": "What is associated with Cerebrooculonasal syndrome?",
    "seeds": [
      "Cerebrooculonasal syndrome"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10874",
    "question": "What is associated with Developmental stagnation?",
    "seeds": [
      "Developmental stagnation"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10875",
    "question": "What is associated with Tooth agenesis, selective, X-linked, 1?",
    "seeds": [
      "Tooth agenesis, selective, X-linked, 1"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10876",
    "question": "What is associated with Platelet factor 3 deficiency?",
    "seeds": [
      "Platelet factor 3 deficiency"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10877",
    "question": "What is associated with Pseudodiastrophic dysplasia?",
    "seeds": [
      "Pseudodiastrophic dysplasia"
    ],
    "gold_answer": "Abnormal maternal serum screening",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10878",
    "question": "What is associated with Sandal gap?",
    "seeds": [
      "Sandal gap"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10879",
    "question": "What phenotype is associated with Neutropenia, severe congenital, 10, autosomal recessive?",
    "seeds": [
      "Neutropenia, severe congenital, 10, autosomal recessive"
    ],
    "gold_answer": "Dysplastic granulopoesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10880",
    "question": "What is associated with Abnormal arcuate vein morphology?",
    "seeds": [
      "Abnormal arcuate vein morphology"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10881",
    "question": "What is associated with Delayed closure of the anterior fontanelle?",
    "seeds": [
      "Delayed closure of the anterior fontanelle"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10882",
    "question": "What phenotype is associated with Myoclonic epilepsy, familial infantile?",
    "seeds": [
      "Myoclonic epilepsy, familial infantile"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10883",
    "question": "What is associated with Loose anagen hair?",
    "seeds": [
      "Loose anagen hair"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10884",
    "question": "What is associated with Retinal microaneurysm?",
    "seeds": [
      "Retinal microaneurysm"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10885",
    "question": "What phenotype is associated with Jacobsen syndrome?",
    "seeds": [
      "Jacobsen syndrome"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10886",
    "question": "What phenotype is associated with NAIL LOW-SULFUR PROTEIN?",
    "seeds": [
      "NAIL LOW-SULFUR PROTEIN"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10887",
    "question": "What is associated with Epidermal nevus?",
    "seeds": [
      "Epidermal nevus"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10888",
    "question": "What is associated with Elevated urine erythritol level?",
    "seeds": [
      "Elevated urine erythritol level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10889",
    "question": "What is associated with Small epiphyses?",
    "seeds": [
      "Small epiphyses"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10890",
    "question": "What phenotype is associated with Myopathy, distal, infantile-onset?",
    "seeds": [
      "Myopathy, distal, infantile-onset"
    ],
    "gold_answer": "Steppage gait",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10891",
    "question": "What is associated with Paroxysmal choreoathetosis?",
    "seeds": [
      "Paroxysmal choreoathetosis"
    ],
    "gold_answer": "Chorea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10892",
    "question": "What is associated with Urethrocele?",
    "seeds": [
      "Urethrocele"
    ],
    "gold_answer": "Abnormality of the lower urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10893",
    "question": "What is associated with Glycogen storage disease due to muscle phosphofructokinase deficiency?",
    "seeds": [
      "Glycogen storage disease due to muscle phosphofructokinase deficiency"
    ],
    "gold_answer": "Abnormal circulating nucleobase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10894",
    "question": "What is associated with Capillary malformation of the lip?",
    "seeds": [
      "Capillary malformation of the lip"
    ],
    "gold_answer": "Vascular malformation of the lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10895",
    "question": "What is associated with Focal impaired awareness sensory seizure with gustatory features?",
    "seeds": [
      "Focal impaired awareness sensory seizure with gustatory features"
    ],
    "gold_answer": "Focal impaired awareness sensory seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10896",
    "question": "What is associated with Microphthalmia, syndromic 6?",
    "seeds": [
      "Microphthalmia, syndromic 6"
    ],
    "gold_answer": "Clinodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10897",
    "question": "What phenotype is associated with Cone-Rod synaptic disorder, congenital nonprogressive?",
    "seeds": [
      "Cone-Rod synaptic disorder, congenital nonprogressive"
    ],
    "gold_answer": "ERG: Reduced dark-adapted b-wave amplitude",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10898",
    "question": "What is associated with Idiopathic/heritable pulmonary arterial hypertension?",
    "seeds": [
      "Idiopathic/heritable pulmonary arterial hypertension"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10899",
    "question": "What phenotype is associated with Warburg micro syndrome 4?",
    "seeds": [
      "Warburg micro syndrome 4"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10900",
    "question": "What phenotype is associated with Lethal congenital contracture syndrome 7?",
    "seeds": [
      "Lethal congenital contracture syndrome 7"
    ],
    "gold_answer": "Polyhydramnios",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10901",
    "question": "What is associated with Glucocorticoid deficiency 4 with or without mineralocorticoid deficiency?",
    "seeds": [
      "Glucocorticoid deficiency 4 with or without mineralocorticoid deficiency"
    ],
    "gold_answer": "Abnormality of circulating glucocorticoid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10902",
    "question": "What is associated with Abnormal conjunctiva morphology?",
    "seeds": [
      "Abnormal conjunctiva morphology"
    ],
    "gold_answer": "Abnormality of the orbital region",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10903",
    "question": "What phenotype is associated with Chanarin-Dorfman syndrome?",
    "seeds": [
      "Chanarin-Dorfman syndrome"
    ],
    "gold_answer": "Hypoplasia of penis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10904",
    "question": "What is associated with Femoral-facial syndrome?",
    "seeds": [
      "Femoral-facial syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10905",
    "question": "What is associated with Ameliorated by vitamin D?",
    "seeds": [
      "Ameliorated by vitamin D"
    ],
    "gold_answer": "Ameliorated by exposure to medication",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10906",
    "question": "What is associated with Endosteal hyperostosis, Worth type?",
    "seeds": [
      "Endosteal hyperostosis, Worth type"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10907",
    "question": "What is associated with Noonan syndrome 14?",
    "seeds": [
      "Noonan syndrome 14"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10908",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2B?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2B"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10909",
    "question": "What is associated with Distal arthrogryposis type 1?",
    "seeds": [
      "Distal arthrogryposis type 1"
    ],
    "gold_answer": "MYBPC1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10910",
    "question": "What is associated with Familial Mediterranean fever, AR?",
    "seeds": [
      "Familial Mediterranean fever, AR"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10911",
    "question": "What is associated with Tibialis anterior muscle atrophy?",
    "seeds": [
      "Tibialis anterior muscle atrophy"
    ],
    "gold_answer": "Distal lower limb amyotrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10912",
    "question": "What is associated with Hepatorenocardiac degenerative fibrosis?",
    "seeds": [
      "Hepatorenocardiac degenerative fibrosis"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10913",
    "question": "What is associated with Anesthetic-induced rhabdomylosis?",
    "seeds": [
      "Anesthetic-induced rhabdomylosis"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10914",
    "question": "What phenotype is associated with Frontonasal dysplasia 2?",
    "seeds": [
      "Frontonasal dysplasia 2"
    ],
    "gold_answer": "Craniosynostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10915",
    "question": "What is associated with Palmoplantar cutis gyrata?",
    "seeds": [
      "Palmoplantar cutis gyrata"
    ],
    "gold_answer": "Abnormal skin morphology of the palm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10916",
    "question": "What phenotype is associated with Folate malabsorption, hereditary?",
    "seeds": [
      "Folate malabsorption, hereditary"
    ],
    "gold_answer": "Folate-responsive megaloblastic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10917",
    "question": "What is associated with Limb-girdle muscular dystrophy due to POMK deficiency?",
    "seeds": [
      "Limb-girdle muscular dystrophy due to POMK deficiency"
    ],
    "gold_answer": "POMK",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_10918",
    "question": "What is associated with Prominent protruding coccyx?",
    "seeds": [
      "Prominent protruding coccyx"
    ],
    "gold_answer": "Abnormal coccyx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10919",
    "question": "What is associated with Duplication of the distal phalanx of the thumb?",
    "seeds": [
      "Duplication of the distal phalanx of the thumb"
    ],
    "gold_answer": "Duplication of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10920",
    "question": "What is associated with Tibial aplasia-ectrodactyly syndrome?",
    "seeds": [
      "Tibial aplasia-ectrodactyly syndrome"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10921",
    "question": "What is associated with Simplified gyral pattern?",
    "seeds": [
      "Simplified gyral pattern"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10922",
    "question": "What is associated with Cardiac lipoma?",
    "seeds": [
      "Cardiac lipoma"
    ],
    "gold_answer": "Lipoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10923",
    "question": "What is associated with Marfanoid habitus-autosomal recessive intellectual disability syndrome?",
    "seeds": [
      "Marfanoid habitus-autosomal recessive intellectual disability syndrome"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10924",
    "question": "What is associated with Idiopathic hypereosinophilic syndrome?",
    "seeds": [
      "Idiopathic hypereosinophilic syndrome"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10925",
    "question": "What is associated with Asymmetry of the nares?",
    "seeds": [
      "Asymmetry of the nares"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10926",
    "question": "What phenotype is associated with Seckel syndrome?",
    "seeds": [
      "Seckel syndrome"
    ],
    "gold_answer": "Cachexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10927",
    "question": "What is associated with Congenital thrombotic thrombocytopenic purpura?",
    "seeds": [
      "Congenital thrombotic thrombocytopenic purpura"
    ],
    "gold_answer": "ADAMTS13",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_10928",
    "question": "What is associated with Hyperglycinuria?",
    "seeds": [
      "Hyperglycinuria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10929",
    "question": "What phenotype is associated with Hypomandibular faciocranial dysostosis?",
    "seeds": [
      "Hypomandibular faciocranial dysostosis"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10930",
    "question": "What is associated with TYROSINOSIS?",
    "seeds": [
      "TYROSINOSIS"
    ],
    "gold_answer": "Abnormal circulating aromatic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10931",
    "question": "What is associated with Pseudoepiphyses of the phalanges of the hand?",
    "seeds": [
      "Pseudoepiphyses of the phalanges of the hand"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10932",
    "question": "What phenotype is associated with Spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis?",
    "seeds": [
      "Spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10933",
    "question": "What is associated with Spleen hamartoma?",
    "seeds": [
      "Spleen hamartoma"
    ],
    "gold_answer": "Hamartoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10934",
    "question": "What is associated with Eosinophil nuclear hypersegmentation?",
    "seeds": [
      "Eosinophil nuclear hypersegmentation"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10935",
    "question": "What is associated with Intestinal dysmotility syndrome?",
    "seeds": [
      "Intestinal dysmotility syndrome"
    ],
    "gold_answer": "Abnormality of the amniotic fluid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10936",
    "question": "What is associated with Bowed humerus?",
    "seeds": [
      "Bowed humerus"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10937",
    "question": "What is associated with Ring chromosome 13 syndrome?",
    "seeds": [
      "Ring chromosome 13 syndrome"
    ],
    "gold_answer": "Thin corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10938",
    "question": "What is associated with Irregular epiphyses of the 3rd finger?",
    "seeds": [
      "Irregular epiphyses of the 3rd finger"
    ],
    "gold_answer": "Irregular epiphyses of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10939",
    "question": "What is associated with Elevated circulating aspartate aminotransferase concentration?",
    "seeds": [
      "Elevated circulating aspartate aminotransferase concentration"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10940",
    "question": "What is associated with Squamous metaplasia?",
    "seeds": [
      "Squamous metaplasia"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10941",
    "question": "What is associated with Elevated urinary N-tau-ribosylhistidine level?",
    "seeds": [
      "Elevated urinary N-tau-ribosylhistidine level"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10942",
    "question": "What is associated with Melanoma-Astrocytoma syndrome?",
    "seeds": [
      "Melanoma-Astrocytoma syndrome"
    ],
    "gold_answer": "Malignant neoplasm of the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10943",
    "question": "What is associated with Right ventricular regional wall motion abnormality?",
    "seeds": [
      "Right ventricular regional wall motion abnormality"
    ],
    "gold_answer": "Abnormal right ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10944",
    "question": "What phenotype is associated with Epilepsy, nocturnal frontal lobe, type 1?",
    "seeds": [
      "Epilepsy, nocturnal frontal lobe, type 1"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10945",
    "question": "What is associated with Highly arched eyebrow?",
    "seeds": [
      "Highly arched eyebrow"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10946",
    "question": "What phenotype is associated with Congenital dyserythropoietic anemia type III?",
    "seeds": [
      "Congenital dyserythropoietic anemia type III"
    ],
    "gold_answer": "Abnormal proerythroblast morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10947",
    "question": "What phenotype is associated with Immunodeficiency 131?",
    "seeds": [
      "Immunodeficiency 131"
    ],
    "gold_answer": "Recurrent sinusitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10948",
    "question": "What is associated with Reduced epidermal collagen XVII protein expression?",
    "seeds": [
      "Reduced epidermal collagen XVII protein expression"
    ],
    "gold_answer": "Abnormal epidermal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10949",
    "question": "What is associated with Abnormal timing of light-adapted single flash electroretinogram?",
    "seeds": [
      "Abnormal timing of light-adapted single flash electroretinogram"
    ],
    "gold_answer": "Abnormal full-field electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10950",
    "question": "What is associated with Prolactinoma?",
    "seeds": [
      "Prolactinoma"
    ],
    "gold_answer": "Decreased response to growth hormone stimulation test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10951",
    "question": "What is associated with Patchy sclerosis of thumb phalanx?",
    "seeds": [
      "Patchy sclerosis of thumb phalanx"
    ],
    "gold_answer": "Increased bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10952",
    "question": "What is associated with Placental infarction?",
    "seeds": [
      "Placental infarction"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10953",
    "question": "What is associated with MBD4-related tumor predisposition syndrome?",
    "seeds": [
      "MBD4-related tumor predisposition syndrome"
    ],
    "gold_answer": "MBD4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10954",
    "question": "What is associated with Sex-limited expression?",
    "seeds": [
      "Sex-limited expression"
    ],
    "gold_answer": "Inheritance qualifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10955",
    "question": "What phenotype is associated with Cardiomyopathy, dilated, 1D?",
    "seeds": [
      "Cardiomyopathy, dilated, 1D"
    ],
    "gold_answer": "Incomplete right bundle branch block",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10956",
    "question": "What is associated with Broad forearm bones?",
    "seeds": [
      "Broad forearm bones"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10957",
    "question": "What is associated with White appearance of duodenal mucosa?",
    "seeds": [
      "White appearance of duodenal mucosa"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10958",
    "question": "What is associated with Bracket metacarpal epiphyses?",
    "seeds": [
      "Bracket metacarpal epiphyses"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10959",
    "question": "What is associated with Grade V vesicoureteral reflux?",
    "seeds": [
      "Grade V vesicoureteral reflux"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10960",
    "question": "What phenotype is associated with Prenatal bowing?",
    "seeds": [
      "Prenatal bowing"
    ],
    "gold_answer": "Bowing of the long bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10961",
    "question": "What phenotype is associated with Adult intestinal botulism?",
    "seeds": [
      "Adult intestinal botulism"
    ],
    "gold_answer": "Cerebral palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10962",
    "question": "What is associated with Greater auricular nerve thickening?",
    "seeds": [
      "Greater auricular nerve thickening"
    ],
    "gold_answer": "Abnormal great auricular nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10963",
    "question": "What is associated with Small epiphyses of the metacarpals?",
    "seeds": [
      "Small epiphyses of the metacarpals"
    ],
    "gold_answer": "Abnormal hand epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10964",
    "question": "What is associated with Anti-Bartonella henselae antibody positivity?",
    "seeds": [
      "Anti-Bartonella henselae antibody positivity"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10965",
    "question": "What is associated with Broad phalanges of the 3rd finger?",
    "seeds": [
      "Broad phalanges of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10966",
    "question": "What is associated with Osteosarcoma?",
    "seeds": [
      "Osteosarcoma"
    ],
    "gold_answer": "Abnormality of globe location",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10967",
    "question": "What is associated with Congenital hydrocele?",
    "seeds": [
      "Congenital hydrocele"
    ],
    "gold_answer": "Hydrocele testis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10968",
    "question": "What phenotype is associated with Vesicoureteral reflux 2?",
    "seeds": [
      "Vesicoureteral reflux 2"
    ],
    "gold_answer": "Renal hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10969",
    "question": "What is associated with Encephalopathy, acute, infection-induced, susceptibility to, 9?",
    "seeds": [
      "Encephalopathy, acute, infection-induced, susceptibility to, 9"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10970",
    "question": "What is associated with Deafness, autosomal recessive 125?",
    "seeds": [
      "Deafness, autosomal recessive 125"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10971",
    "question": "What is associated with Osteolytic defects of the phalanges of the hallux?",
    "seeds": [
      "Osteolytic defects of the phalanges of the hallux"
    ],
    "gold_answer": "Abnormal hallux phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10972",
    "question": "What is associated with Undetectable light- and dark-adapted electroretinogram?",
    "seeds": [
      "Undetectable light- and dark-adapted electroretinogram"
    ],
    "gold_answer": "Abnormal light- and dark-adapted electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10973",
    "question": "What is associated with Diamond-Blackfan anemia 11?",
    "seeds": [
      "Diamond-Blackfan anemia 11"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10974",
    "question": "What is associated with KELOIDS?",
    "seeds": [
      "KELOIDS"
    ],
    "gold_answer": "Atypical scarring of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10975",
    "question": "What is associated with Thoracoabdominal ectopia cordis?",
    "seeds": [
      "Thoracoabdominal ectopia cordis"
    ],
    "gold_answer": "Ectopia cordis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10976",
    "question": "What is associated with Common variable immunodeficiency phenotype due to homozygous TACI deficiency?",
    "seeds": [
      "Common variable immunodeficiency phenotype due to homozygous TACI deficiency"
    ],
    "gold_answer": "TNFRSF13B",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_10977",
    "question": "What is associated with Hepatorenocardiac degenerative fibrosis?",
    "seeds": [
      "Hepatorenocardiac degenerative fibrosis"
    ],
    "gold_answer": "Hepatic fibrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10978",
    "question": "What is associated with Aplasia of the optic tract?",
    "seeds": [
      "Aplasia of the optic tract"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the optic tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10979",
    "question": "What phenotype is associated with Deafness, autosomal recessive 21?",
    "seeds": [
      "Deafness, autosomal recessive 21"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10980",
    "question": "What is associated with Pseudoepiphysis of the 5th metacarpal?",
    "seeds": [
      "Pseudoepiphysis of the 5th metacarpal"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10981",
    "question": "What is associated with Slender forearm bones?",
    "seeds": [
      "Slender forearm bones"
    ],
    "gold_answer": "Abnormal forearm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10982",
    "question": "What is associated with Arcuate artery endoarterial foam cell hypercellularity?",
    "seeds": [
      "Arcuate artery endoarterial foam cell hypercellularity"
    ],
    "gold_answer": "Arcuate artery endoarterial leukocyte hypercellularity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10983",
    "question": "What is associated with Aortic aneurysm, familial thoracic 11, susceptibility to?",
    "seeds": [
      "Aortic aneurysm, familial thoracic 11, susceptibility to"
    ],
    "gold_answer": "Vascular dilatation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10984",
    "question": "What is associated with Abnormal erythrocyte physiology?",
    "seeds": [
      "Abnormal erythrocyte physiology"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10985",
    "question": "What phenotype is associated with Platelet disorder, familial, with associated myeloid malignancy?",
    "seeds": [
      "Platelet disorder, familial, with associated myeloid malignancy"
    ],
    "gold_answer": "Petechiae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10986",
    "question": "What is associated with Anti-Zinc transporter 8 antibody positivity?",
    "seeds": [
      "Anti-Zinc transporter 8 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10987",
    "question": "What is associated with Esophageal leukoplakia?",
    "seeds": [
      "Esophageal leukoplakia"
    ],
    "gold_answer": "Abnormal esophagus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10988",
    "question": "What is associated with 3-methylglutaconic aciduria, type III?",
    "seeds": [
      "3-methylglutaconic aciduria, type III"
    ],
    "gold_answer": "Abnormal pyramidal sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10989",
    "question": "What is associated with Abnormal tongue physiology?",
    "seeds": [
      "Abnormal tongue physiology"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10990",
    "question": "What phenotype is associated with Spastic paraplegia 84, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 84, autosomal recessive"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10991",
    "question": "What phenotype is associated with Pituitary adenoma 5, multiple types?",
    "seeds": [
      "Pituitary adenoma 5, multiple types"
    ],
    "gold_answer": "Pituitary adenoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10992",
    "question": "What is associated with Abnormality of the urinary system physiology?",
    "seeds": [
      "Abnormality of the urinary system physiology"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10993",
    "question": "What is associated with Sneddon syndrome?",
    "seeds": [
      "Sneddon syndrome"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10994",
    "question": "What is associated with Meier-Gorlin syndrome 5?",
    "seeds": [
      "Meier-Gorlin syndrome 5"
    ],
    "gold_answer": "Abnormal elbow physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10995",
    "question": "What is associated with Autosomal dominant spastic paraplegia type 73?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 73"
    ],
    "gold_answer": "Abnormal corticospinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10996",
    "question": "What phenotype is associated with Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8?",
    "seeds": [
      "Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_10997",
    "question": "What is associated with HbH hemoglobin?",
    "seeds": [
      "HbH hemoglobin"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10998",
    "question": "What is associated with Focal impaired awareness pedal automatism seizure?",
    "seeds": [
      "Focal impaired awareness pedal automatism seizure"
    ],
    "gold_answer": "Focal impaired awareness motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_10999",
    "question": "What is associated with Absent earlobe?",
    "seeds": [
      "Absent earlobe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the earlobes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11000",
    "question": "What is associated with Koeppe nodules?",
    "seeds": [
      "Koeppe nodules"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11001",
    "question": "What phenotype is associated with Heterotaxy, visceral, 10, autosomal, with male infertility?",
    "seeds": [
      "Heterotaxy, visceral, 10, autosomal, with male infertility"
    ],
    "gold_answer": "Cough",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11002",
    "question": "What is associated with Acute basophilic leukemia?",
    "seeds": [
      "Acute basophilic leukemia"
    ],
    "gold_answer": "GATA1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_11003",
    "question": "What phenotype is associated with Calciphylaxis?",
    "seeds": [
      "Calciphylaxis"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11004",
    "question": "What is associated with Skin fragility with non-scarring blistering?",
    "seeds": [
      "Skin fragility with non-scarring blistering"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11005",
    "question": "What is associated with Bracket epiphysis of the distal phalanx of the 4th finger?",
    "seeds": [
      "Bracket epiphysis of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal distal phalanx morphology of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11006",
    "question": "What is associated with Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements?",
    "seeds": [
      "Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements"
    ],
    "gold_answer": "Unusual infection by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11007",
    "question": "What is associated with Elevated urinary collagen degradation products?",
    "seeds": [
      "Elevated urinary collagen degradation products"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11008",
    "question": "What is associated with Thenar muscle atrophy?",
    "seeds": [
      "Thenar muscle atrophy"
    ],
    "gold_answer": "Distal upper limb amyotrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11009",
    "question": "What is associated with High urinary gonadotropin level?",
    "seeds": [
      "High urinary gonadotropin level"
    ],
    "gold_answer": "Abnormal urine hormone level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11010",
    "question": "What phenotype is associated with Bruck syndrome 2?",
    "seeds": [
      "Bruck syndrome 2"
    ],
    "gold_answer": "Flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11011",
    "question": "What is associated with Uterine leiomyosarcoma?",
    "seeds": [
      "Uterine leiomyosarcoma"
    ],
    "gold_answer": "Uterine neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11012",
    "question": "What is associated with Cutis laxa, autosomal recessive, type IIIB?",
    "seeds": [
      "Cutis laxa, autosomal recessive, type IIIB"
    ],
    "gold_answer": "Abnormal nasal dorsum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11013",
    "question": "What is associated with Prenatal benign hypophosphatasia?",
    "seeds": [
      "Prenatal benign hypophosphatasia"
    ],
    "gold_answer": "ALPL",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_11014",
    "question": "What phenotype is associated with Arrhythmogenic right ventricular dysplasia 1?",
    "seeds": [
      "Arrhythmogenic right ventricular dysplasia 1"
    ],
    "gold_answer": "Sudden cardiac death",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11015",
    "question": "What is associated with Supernormal dark-adapted bright flash electroretinogram b-wave?",
    "seeds": [
      "Supernormal dark-adapted bright flash electroretinogram b-wave"
    ],
    "gold_answer": "Abnormal dark-adapted electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11016",
    "question": "What is associated with Antidromic atrioventricular reentrant tachycardia?",
    "seeds": [
      "Antidromic atrioventricular reentrant tachycardia"
    ],
    "gold_answer": "Atrioventricular reentrant tachycardia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11017",
    "question": "What is associated with Absent soft palate?",
    "seeds": [
      "Absent soft palate"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11018",
    "question": "What is associated with Abnormal cardiac septum morphology?",
    "seeds": [
      "Abnormal cardiac septum morphology"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11019",
    "question": "What is associated with PR segment elevation?",
    "seeds": [
      "PR segment elevation"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11020",
    "question": "What phenotype is associated with Insulinomatosis and diabetes mellitus?",
    "seeds": [
      "Insulinomatosis and diabetes mellitus"
    ],
    "gold_answer": "Insulinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11021",
    "question": "What is associated with BCGitis?",
    "seeds": [
      "BCGitis"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11022",
    "question": "What is associated with Advanced ossification of carpal bones?",
    "seeds": [
      "Advanced ossification of carpal bones"
    ],
    "gold_answer": "Abnormality of carpal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11023",
    "question": "What is associated with Chronic decreased circulating IgG3?",
    "seeds": [
      "Chronic decreased circulating IgG3"
    ],
    "gold_answer": "Decreased circulating IgG subclass concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11024",
    "question": "What is associated with Long QT syndrome 16?",
    "seeds": [
      "Long QT syndrome 16"
    ],
    "gold_answer": "Abnormal QT interval",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11025",
    "question": "What is associated with Schisis association?",
    "seeds": [
      "Schisis association"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11026",
    "question": "What phenotype is associated with Alexander disease type II?",
    "seeds": [
      "Alexander disease type II"
    ],
    "gold_answer": "Sleep abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11027",
    "question": "What phenotype is associated with Dystonia with cerebellar atrophy?",
    "seeds": [
      "Dystonia with cerebellar atrophy"
    ],
    "gold_answer": "Gaze-evoked horizontal nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11028",
    "question": "What is associated with 3-M syndrome 3?",
    "seeds": [
      "3-M syndrome 3"
    ],
    "gold_answer": "Abnormality of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11029",
    "question": "What is associated with Abnormal 2nd toe phalanx morphology?",
    "seeds": [
      "Abnormal 2nd toe phalanx morphology"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11030",
    "question": "What is associated with Deafness, autosomal dominant nonsyndromic sensorineural 11?",
    "seeds": [
      "Deafness, autosomal dominant nonsyndromic sensorineural 11"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11031",
    "question": "What is associated with Fungi allergy?",
    "seeds": [
      "Fungi allergy"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11032",
    "question": "What is associated with Low-frequency sensorineural hearing impairment?",
    "seeds": [
      "Low-frequency sensorineural hearing impairment"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11033",
    "question": "What is associated with Reduced epidermal keratin protein expression?",
    "seeds": [
      "Reduced epidermal keratin protein expression"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11034",
    "question": "What is associated with Broad middle phalanx of the 5th toe?",
    "seeds": [
      "Broad middle phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal fifth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11035",
    "question": "What phenotype is associated with HNF1B-related autosomal dominant tubulointerstitial kidney disease?",
    "seeds": [
      "HNF1B-related autosomal dominant tubulointerstitial kidney disease"
    ],
    "gold_answer": "Horseshoe kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11036",
    "question": "What is associated with Nephronophthisis 11?",
    "seeds": [
      "Nephronophthisis 11"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11037",
    "question": "What is associated with Decreased circulating alpha-mannosidase activity?",
    "seeds": [
      "Decreased circulating alpha-mannosidase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11038",
    "question": "What is associated with Pinhole visual acuity 1.2 LogMAR?",
    "seeds": [
      "Pinhole visual acuity 1.2 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11039",
    "question": "What is associated with Familial thoracic aortic aneurysm and aortic dissection?",
    "seeds": [
      "Familial thoracic aortic aneurysm and aortic dissection"
    ],
    "gold_answer": "Narrow palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11040",
    "question": "What is associated with Generalized muscle weakness?",
    "seeds": [
      "Generalized muscle weakness"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11041",
    "question": "What is associated with Perivascular myocardial immune cell infiltration?",
    "seeds": [
      "Perivascular myocardial immune cell infiltration"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11042",
    "question": "What is associated with Abnormality of the nervous system?",
    "seeds": [
      "Abnormality of the nervous system"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11043",
    "question": "What phenotype is associated with Lead poisoning?",
    "seeds": [
      "Lead poisoning"
    ],
    "gold_answer": "Preeclampsia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11044",
    "question": "What is associated with Hypoglycemic seizures?",
    "seeds": [
      "Hypoglycemic seizures"
    ],
    "gold_answer": "Hypoglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11045",
    "question": "What is associated with Follicular hyperplasia?",
    "seeds": [
      "Follicular hyperplasia"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11046",
    "question": "What is associated with 19p13.12 microdeletion syndrome?",
    "seeds": [
      "19p13.12 microdeletion syndrome"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11047",
    "question": "What is associated with Horner syndrome?",
    "seeds": [
      "Horner syndrome"
    ],
    "gold_answer": "Abnormality of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11048",
    "question": "What is associated with Congenital cataracts-facial dysmorphism-neuropathy syndrome?",
    "seeds": [
      "Congenital cataracts-facial dysmorphism-neuropathy syndrome"
    ],
    "gold_answer": "Abnormal nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11049",
    "question": "What phenotype is associated with Atrichia with papular lesions?",
    "seeds": [
      "Atrichia with papular lesions"
    ],
    "gold_answer": "Generalized papillary lesions",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11050",
    "question": "What is associated with Glutaricaciduria, type I?",
    "seeds": [
      "Glutaricaciduria, type I"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11051",
    "question": "What is associated with Male urethral meatus stenosis?",
    "seeds": [
      "Male urethral meatus stenosis"
    ],
    "gold_answer": "Abnormal male urethral meatus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11052",
    "question": "What is associated with Hypercitraturia?",
    "seeds": [
      "Hypercitraturia"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11053",
    "question": "What is associated with Maintenance insomnia?",
    "seeds": [
      "Maintenance insomnia"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11054",
    "question": "What is associated with Leucine crystalluria?",
    "seeds": [
      "Leucine crystalluria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11055",
    "question": "What is associated with Stage 3 chronic kidney disease?",
    "seeds": [
      "Stage 3 chronic kidney disease"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11056",
    "question": "What phenotype is associated with Graves disease?",
    "seeds": [
      "Graves disease"
    ],
    "gold_answer": "Onycholysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11057",
    "question": "What phenotype is associated with Microcephaly 8, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 8, primary, autosomal recessive"
    ],
    "gold_answer": "Severe intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11058",
    "question": "What is associated with Abnormal 5th finger morphology?",
    "seeds": [
      "Abnormal 5th finger morphology"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11059",
    "question": "What is associated with Type II lissencephaly?",
    "seeds": [
      "Type II lissencephaly"
    ],
    "gold_answer": "Lissencephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11060",
    "question": "What phenotype is associated with Amyotrophic lateral sclerosis 4, juvenile?",
    "seeds": [
      "Amyotrophic lateral sclerosis 4, juvenile"
    ],
    "gold_answer": "Babinski sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11061",
    "question": "What is associated with Tuberous sclerosis complex?",
    "seeds": [
      "Tuberous sclerosis complex"
    ],
    "gold_answer": "Fibrous tissue neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11062",
    "question": "What is associated with Congenital microcoria?",
    "seeds": [
      "Congenital microcoria"
    ],
    "gold_answer": "Asymmetry of intraocular pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11063",
    "question": "What is associated with Multicentric osteolysis-nodulosis-arthropathy spectrum?",
    "seeds": [
      "Multicentric osteolysis-nodulosis-arthropathy spectrum"
    ],
    "gold_answer": "Abnormal aortic arch morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11064",
    "question": "What is associated with Cardiomyopathy, dilated, 2H?",
    "seeds": [
      "Cardiomyopathy, dilated, 2H"
    ],
    "gold_answer": "Respiratory arrest",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11065",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 67?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 67"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebellar vermis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11066",
    "question": "What is associated with Abnormal vestibular saccule morphology?",
    "seeds": [
      "Abnormal vestibular saccule morphology"
    ],
    "gold_answer": "Abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11067",
    "question": "What is associated with Increased size of the clitoris?",
    "seeds": [
      "Increased size of the clitoris"
    ],
    "gold_answer": "Abnormal clitoris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11068",
    "question": "What is associated with Mottled pigmentation of photoexposed areas?",
    "seeds": [
      "Mottled pigmentation of photoexposed areas"
    ],
    "gold_answer": "Mottled pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11069",
    "question": "What phenotype is associated with Periventricular nodular heterotopia 9?",
    "seeds": [
      "Periventricular nodular heterotopia 9"
    ],
    "gold_answer": "Unilateral conductive hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11070",
    "question": "What is associated with Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome?",
    "seeds": [
      "Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome"
    ],
    "gold_answer": "Palmoplantar hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11071",
    "question": "What is associated with Aplasia/Hypoplasia of the 4th toe?",
    "seeds": [
      "Aplasia/Hypoplasia of the 4th toe"
    ],
    "gold_answer": "Absent toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11072",
    "question": "What is associated with Dysorthography?",
    "seeds": [
      "Dysorthography"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11073",
    "question": "What is associated with Small epiphysis of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Small epiphysis of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the proximal phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11074",
    "question": "What is associated with Increased CSF threonine concentration?",
    "seeds": [
      "Increased CSF threonine concentration"
    ],
    "gold_answer": "Abnormal CSF threonine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11075",
    "question": "What is associated with Abnormal circulating insulin concentration?",
    "seeds": [
      "Abnormal circulating insulin concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11076",
    "question": "What is associated with Bile acid conjugation defect 1?",
    "seeds": [
      "Bile acid conjugation defect 1"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11077",
    "question": "What is associated with Alopecia-intellectual disability syndrome 4?",
    "seeds": [
      "Alopecia-intellectual disability syndrome 4"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11078",
    "question": "What is associated with Positive urine opioid test?",
    "seeds": [
      "Positive urine opioid test"
    ],
    "gold_answer": "Urine xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11079",
    "question": "What is associated with Positive tuberculin skin test?",
    "seeds": [
      "Positive tuberculin skin test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11080",
    "question": "What is associated with Chilblains?",
    "seeds": [
      "Chilblains"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11081",
    "question": "What is associated with Distal widening of metacarpals?",
    "seeds": [
      "Distal widening of metacarpals"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11082",
    "question": "What is associated with Alcohol sensitivity, acute?",
    "seeds": [
      "Alcohol sensitivity, acute"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11083",
    "question": "What phenotype is associated with 46,XY difference of sex development due to 5-alpha-reductase 2 deficiency?",
    "seeds": [
      "46,XY difference of sex development due to 5-alpha-reductase 2 deficiency"
    ],
    "gold_answer": "Small scrotum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11084",
    "question": "What is associated with Uruguay faciocardiomusculoskeletal syndrome?",
    "seeds": [
      "Uruguay faciocardiomusculoskeletal syndrome"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11085",
    "question": "What is associated with Superior rib anomalies?",
    "seeds": [
      "Superior rib anomalies"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11086",
    "question": "What is associated with Cutaneous anergy?",
    "seeds": [
      "Cutaneous anergy"
    ],
    "gold_answer": "Abnormal T cell physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11087",
    "question": "What is associated with Non-polarized lymph node germinal centers?",
    "seeds": [
      "Non-polarized lymph node germinal centers"
    ],
    "gold_answer": "Abnormal lymph-node tissue architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11088",
    "question": "What is associated with Type 1 congenital pulmonary airway malformation?",
    "seeds": [
      "Type 1 congenital pulmonary airway malformation"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11089",
    "question": "What is associated with Esophageal web?",
    "seeds": [
      "Esophageal web"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11090",
    "question": "What phenotype is associated with Maternal uniparental disomy of chromosome 2 syndrome?",
    "seeds": [
      "Maternal uniparental disomy of chromosome 2 syndrome"
    ],
    "gold_answer": "Renal hypoplasia/aplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11091",
    "question": "What is associated with Bartter syndrome, type 1, antenatal?",
    "seeds": [
      "Bartter syndrome, type 1, antenatal"
    ],
    "gold_answer": "Abnormality of the parathyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11092",
    "question": "What is associated with Limb apraxia?",
    "seeds": [
      "Limb apraxia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11093",
    "question": "What phenotype is associated with Craniotubular dysplasia, Ikegawa type?",
    "seeds": [
      "Craniotubular dysplasia, Ikegawa type"
    ],
    "gold_answer": "Broad ischia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11094",
    "question": "What is associated with Intervertebral disk calcification?",
    "seeds": [
      "Intervertebral disk calcification"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11095",
    "question": "What is associated with Ectopic ureteral orifice?",
    "seeds": [
      "Ectopic ureteral orifice"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11096",
    "question": "What is associated with Meningocele?",
    "seeds": [
      "Meningocele"
    ],
    "gold_answer": "Closed neural tube defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11097",
    "question": "What is associated with Dilatation of celiac artery?",
    "seeds": [
      "Dilatation of celiac artery"
    ],
    "gold_answer": "Dilatation of an abdominal artery",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11098",
    "question": "What phenotype is associated with Congenital respiratory-biliary fistula?",
    "seeds": [
      "Congenital respiratory-biliary fistula"
    ],
    "gold_answer": "Tracheal stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11099",
    "question": "What is associated with Focal cortical dysplasia type II?",
    "seeds": [
      "Focal cortical dysplasia type II"
    ],
    "gold_answer": "Cortical dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11100",
    "question": "What is associated with Abnormal brainstem morphology?",
    "seeds": [
      "Abnormal brainstem morphology"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11101",
    "question": "What phenotype is associated with Lethal congenital contracture syndrome 1?",
    "seeds": [
      "Lethal congenital contracture syndrome 1"
    ],
    "gold_answer": "Hypoplasia of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11102",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Sclerosis of proximal phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11103",
    "question": "What is associated with Intermittent hyperventilation?",
    "seeds": [
      "Intermittent hyperventilation"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11104",
    "question": "What is associated with Combined immunodeficiency-multiple intestinal atresia?",
    "seeds": [
      "Combined immunodeficiency-multiple intestinal atresia"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11105",
    "question": "What is associated with Abnormality of the respiratory system?",
    "seeds": [
      "Abnormality of the respiratory system"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11106",
    "question": "What is associated with Abnormal circulating nitrogen compound concentration?",
    "seeds": [
      "Abnormal circulating nitrogen compound concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11107",
    "question": "What is associated with Abnormal nasal bone morphology?",
    "seeds": [
      "Abnormal nasal bone morphology"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11108",
    "question": "What is associated with Tenesmus?",
    "seeds": [
      "Tenesmus"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11109",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 2?",
    "seeds": [
      "Ciliary dyskinesia, primary, 2"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11110",
    "question": "What is associated with Seckel syndrome 6?",
    "seeds": [
      "Seckel syndrome 6"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11111",
    "question": "What is associated with Desmoplastic/nodular medulloblastoma?",
    "seeds": [
      "Desmoplastic/nodular medulloblastoma"
    ],
    "gold_answer": "SUFU",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_11112",
    "question": "What is associated with Spheroid bodies?",
    "seeds": [
      "Spheroid bodies"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11113",
    "question": "What phenotype is associated with Anemia, sideroblastic, X-linked?",
    "seeds": [
      "Anemia, sideroblastic, X-linked"
    ],
    "gold_answer": "Hypochromic microcytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11114",
    "question": "What is associated with Penile freckling?",
    "seeds": [
      "Penile freckling"
    ],
    "gold_answer": "Abnormal penis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11115",
    "question": "What is associated with Cone-shaped epiphysis of the 1st metacarpal?",
    "seeds": [
      "Cone-shaped epiphysis of the 1st metacarpal"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11116",
    "question": "What is associated with Anotia?",
    "seeds": [
      "Anotia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the external ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11117",
    "question": "What is associated with Complete duplication of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Complete duplication of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Complete duplication of the phalanges of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11118",
    "question": "What phenotype is associated with Osteogenesis imperfecta, type IX?",
    "seeds": [
      "Osteogenesis imperfecta, type IX"
    ],
    "gold_answer": "Hyperextensibility at elbow",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11119",
    "question": "What is associated with Craniosynostosis with fibular aplasia?",
    "seeds": [
      "Craniosynostosis with fibular aplasia"
    ],
    "gold_answer": "Abnormal fibula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11120",
    "question": "What is associated with Elongated femoral neck?",
    "seeds": [
      "Elongated femoral neck"
    ],
    "gold_answer": "Abnormal femoral neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11121",
    "question": "What is associated with Abnormality of the extraocular muscles?",
    "seeds": [
      "Abnormality of the extraocular muscles"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11122",
    "question": "What is associated with Spoken word recognition deficit?",
    "seeds": [
      "Spoken word recognition deficit"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11123",
    "question": "What is associated with Tetany?",
    "seeds": [
      "Tetany"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11124",
    "question": "What is associated with Chromosome 22q11.2 deletion syndrome, distal?",
    "seeds": [
      "Chromosome 22q11.2 deletion syndrome, distal"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11125",
    "question": "What is associated with Spermatogenic failure 92?",
    "seeds": [
      "Spermatogenic failure 92"
    ],
    "gold_answer": "Decreased fertility in males",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11126",
    "question": "What is associated with Reduced euglobulin clot lysis time?",
    "seeds": [
      "Reduced euglobulin clot lysis time"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11127",
    "question": "What is associated with Absent cervical vertebra?",
    "seeds": [
      "Absent cervical vertebra"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the vertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11128",
    "question": "What is associated with Anauxetic dysplasia 2?",
    "seeds": [
      "Anauxetic dysplasia 2"
    ],
    "gold_answer": "Macrocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11129",
    "question": "What is associated with Sertoli cell hyperplasia?",
    "seeds": [
      "Sertoli cell hyperplasia"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11130",
    "question": "What is associated with Anemia, dyserythropoietic congenital, type IV?",
    "seeds": [
      "Anemia, dyserythropoietic congenital, type IV"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11131",
    "question": "What is associated with Bilateral superior vena cava with no bridging vein?",
    "seeds": [
      "Bilateral superior vena cava with no bridging vein"
    ],
    "gold_answer": "Persistent left superior vena cava",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11132",
    "question": "What is associated with Sinus bradycardia?",
    "seeds": [
      "Sinus bradycardia"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11133",
    "question": "What is associated with Enlarged humeral metaphyses?",
    "seeds": [
      "Enlarged humeral metaphyses"
    ],
    "gold_answer": "Abnormal upper limb metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11134",
    "question": "What is associated with Wieacker-Wolff syndrome?",
    "seeds": [
      "Wieacker-Wolff syndrome"
    ],
    "gold_answer": "Limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11135",
    "question": "What phenotype is associated with Congenital myopathy 18 due to dihydropyridine receptor defect?",
    "seeds": [
      "Congenital myopathy 18 due to dihydropyridine receptor defect"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11136",
    "question": "What is associated with Wet voice?",
    "seeds": [
      "Wet voice"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11137",
    "question": "What is associated with Exercise-induced muscle cramps?",
    "seeds": [
      "Exercise-induced muscle cramps"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11138",
    "question": "What is associated with Absent proximal phalanx of thumb?",
    "seeds": [
      "Absent proximal phalanx of thumb"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11139",
    "question": "What is associated with Autosomal dominant prognathism?",
    "seeds": [
      "Autosomal dominant prognathism"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11140",
    "question": "What is associated with Hypoornithinemia?",
    "seeds": [
      "Hypoornithinemia"
    ],
    "gold_answer": "Abnormal circulating non-proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11141",
    "question": "What is associated with Epidermolysis bullosa pruriginosa?",
    "seeds": [
      "Epidermolysis bullosa pruriginosa"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11142",
    "question": "What is associated with Membranous vitreous appearance?",
    "seeds": [
      "Membranous vitreous appearance"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11143",
    "question": "What phenotype is associated with Insulinoma?",
    "seeds": [
      "Insulinoma"
    ],
    "gold_answer": "Hypokalemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11144",
    "question": "What is associated with Positive urine cocaine test?",
    "seeds": [
      "Positive urine cocaine test"
    ],
    "gold_answer": "Urine xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11145",
    "question": "What is associated with Schwannomatosis?",
    "seeds": [
      "Schwannomatosis"
    ],
    "gold_answer": "Central hypothyroidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11146",
    "question": "What is associated with Rabson-Mendenhall syndrome?",
    "seeds": [
      "Rabson-Mendenhall syndrome"
    ],
    "gold_answer": "Increased size of the clitoris",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11147",
    "question": "What is associated with Broad phalanx?",
    "seeds": [
      "Broad phalanx"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11148",
    "question": "What is associated with Progressive flexion contractures?",
    "seeds": [
      "Progressive flexion contractures"
    ],
    "gold_answer": "Flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11149",
    "question": "What is associated with Asymmetrical gluteal crease?",
    "seeds": [
      "Asymmetrical gluteal crease"
    ],
    "gold_answer": "Abnormality of the musculature of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11150",
    "question": "What is associated with Limited shoulder internal rotation?",
    "seeds": [
      "Limited shoulder internal rotation"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11151",
    "question": "What is associated with Sclerosis of the distal phalanx of the 4th finger?",
    "seeds": [
      "Sclerosis of the distal phalanx of the 4th finger"
    ],
    "gold_answer": "Sclerosis of 4th finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11152",
    "question": "What is associated with Abnormal morphology of the proximal phalanx of the hallux?",
    "seeds": [
      "Abnormal morphology of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11153",
    "question": "What is associated with Clinodactyly?",
    "seeds": [
      "Clinodactyly"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11154",
    "question": "What is associated with Recurrent bacterial vaginosis?",
    "seeds": [
      "Recurrent bacterial vaginosis"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11155",
    "question": "What is associated with Iris cyst?",
    "seeds": [
      "Iris cyst"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11156",
    "question": "What is associated with Abnormality of glycosaminoglycan metabolism?",
    "seeds": [
      "Abnormality of glycosaminoglycan metabolism"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11157",
    "question": "What phenotype is associated with Amelogenesis imperfecta, hypoplastic/hypomaturation, X-linked 2?",
    "seeds": [
      "Amelogenesis imperfecta, hypoplastic/hypomaturation, X-linked 2"
    ],
    "gold_answer": "Amelogenesis imperfecta",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11158",
    "question": "What is associated with Decreased nerve conduction velocity?",
    "seeds": [
      "Decreased nerve conduction velocity"
    ],
    "gold_answer": "Abnormality of peripheral nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11159",
    "question": "What is associated with CD38 expression?",
    "seeds": [
      "CD38 expression"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11160",
    "question": "What is associated with Abnormal circulating inhibin B concentration?",
    "seeds": [
      "Abnormal circulating inhibin B concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11161",
    "question": "What is associated with Bothnia retinal dystrophy?",
    "seeds": [
      "Bothnia retinal dystrophy"
    ],
    "gold_answer": "Visual loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11162",
    "question": "What is associated with Microcephalic osteodysplastic primordial dwarfism, type II?",
    "seeds": [
      "Microcephalic osteodysplastic primordial dwarfism, type II"
    ],
    "gold_answer": "Short phalanx of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11163",
    "question": "What is associated with Nephrotic syndrome, type 4?",
    "seeds": [
      "Nephrotic syndrome, type 4"
    ],
    "gold_answer": "Glomerular sclerosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11164",
    "question": "What is associated with Complete congenital stationary night blindness, Schubert-Bornschein type?",
    "seeds": [
      "Complete congenital stationary night blindness, Schubert-Bornschein type"
    ],
    "gold_answer": "TRPM1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_11165",
    "question": "What is associated with Positive respiratory tract infectious agent test?",
    "seeds": [
      "Positive respiratory tract infectious agent test"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11166",
    "question": "What phenotype is associated with Turnpenny-Fry syndrome?",
    "seeds": [
      "Turnpenny-Fry syndrome"
    ],
    "gold_answer": "Constipation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11167",
    "question": "What is associated with Complete duplication of the phalanges of the 2nd toe?",
    "seeds": [
      "Complete duplication of the phalanges of the 2nd toe"
    ],
    "gold_answer": "Abnormal second toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11168",
    "question": "What is associated with Dermoid cyst?",
    "seeds": [
      "Dermoid cyst"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11169",
    "question": "What is associated with Atelencephaly?",
    "seeds": [
      "Atelencephaly"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11170",
    "question": "What is associated with Limited repertoire of facial expression?",
    "seeds": [
      "Limited repertoire of facial expression"
    ],
    "gold_answer": "Abnormal nonverbal communicative behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11171",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type IR?",
    "seeds": [
      "Congenital disorder of glycosylation, type IR"
    ],
    "gold_answer": "Failure to thrive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11172",
    "question": "What is associated with Hypocalcemic vitamin D-resistant rickets?",
    "seeds": [
      "Hypocalcemic vitamin D-resistant rickets"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11173",
    "question": "What is associated with Methylmalonic aciduria, vitamin B12-responsive, cblA type?",
    "seeds": [
      "Methylmalonic aciduria, vitamin B12-responsive, cblA type"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11174",
    "question": "What phenotype is associated with Tooth agenesis, selective, 9?",
    "seeds": [
      "Tooth agenesis, selective, 9"
    ],
    "gold_answer": "Microdontia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11175",
    "question": "What is associated with Jaw pain?",
    "seeds": [
      "Jaw pain"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11176",
    "question": "What is associated with Reduced erythrocyte 2,3-diphosphoglycerate concentration?",
    "seeds": [
      "Reduced erythrocyte 2,3-diphosphoglycerate concentration"
    ],
    "gold_answer": "Abnormal erythrocyte metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11177",
    "question": "What phenotype is associated with Migraine without aura, susceptibility to, 4?",
    "seeds": [
      "Migraine without aura, susceptibility to, 4"
    ],
    "gold_answer": "Nausea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11178",
    "question": "What is associated with Hydronephrosis?",
    "seeds": [
      "Hydronephrosis"
    ],
    "gold_answer": "Dilatation of the renal pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11179",
    "question": "What is associated with Cerebral perivascular enhancement pattern?",
    "seeds": [
      "Cerebral perivascular enhancement pattern"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11180",
    "question": "What is associated with Stickler syndrome, type I?",
    "seeds": [
      "Stickler syndrome, type I"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11181",
    "question": "What is associated with Abnormal sperm mid-piece morphology?",
    "seeds": [
      "Abnormal sperm mid-piece morphology"
    ],
    "gold_answer": "Abnormal germ cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11182",
    "question": "What is associated with Hypoglycemia?",
    "seeds": [
      "Hypoglycemia"
    ],
    "gold_answer": "Abnormal glucose homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11183",
    "question": "What is associated with 48,XXYY syndrome?",
    "seeds": [
      "48,XXYY syndrome"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11184",
    "question": "What is associated with Autosomal recessive Emery-Dreifuss muscular dystrophy?",
    "seeds": [
      "Autosomal recessive Emery-Dreifuss muscular dystrophy"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11185",
    "question": "What is associated with Hypoplastic facial bones?",
    "seeds": [
      "Hypoplastic facial bones"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11186",
    "question": "What is associated with Cone-shaped capital femoral epiphysis?",
    "seeds": [
      "Cone-shaped capital femoral epiphysis"
    ],
    "gold_answer": "Abnormality of the epiphysis of the femoral head",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11187",
    "question": "What phenotype is associated with Lactate dehydrogenase B deficiency?",
    "seeds": [
      "Lactate dehydrogenase B deficiency"
    ],
    "gold_answer": "Reduced circulating lactate dehydrogenase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11188",
    "question": "What is associated with Brain neoplasm?",
    "seeds": [
      "Brain neoplasm"
    ],
    "gold_answer": "Neoplasm of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11189",
    "question": "What is associated with Recent foraged mushroom consumption?",
    "seeds": [
      "Recent foraged mushroom consumption"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11190",
    "question": "What is associated with Reduced circulating interleukin 27 concentration?",
    "seeds": [
      "Reduced circulating interleukin 27 concentration"
    ],
    "gold_answer": "Abnormal circulating interleukin 27 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11191",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked syndromic, Cabezas type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic, Cabezas type"
    ],
    "gold_answer": "Micropenis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11192",
    "question": "What is associated with Parasite allergy?",
    "seeds": [
      "Parasite allergy"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11193",
    "question": "What is associated with Paraplegia?",
    "seeds": [
      "Paraplegia"
    ],
    "gold_answer": "Weakness due to upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11194",
    "question": "What is associated with X-linked adrenoleukodystrophy?",
    "seeds": [
      "X-linked adrenoleukodystrophy"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11195",
    "question": "What is associated with Branchial sinus?",
    "seeds": [
      "Branchial sinus"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11196",
    "question": "What phenotype is associated with Hyperostosis cranialis interna?",
    "seeds": [
      "Hyperostosis cranialis interna"
    ],
    "gold_answer": "Occipital horn",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11197",
    "question": "What is associated with Abnormal circulating nucleobase concentration?",
    "seeds": [
      "Abnormal circulating nucleobase concentration"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11198",
    "question": "What phenotype is associated with Centronuclear myopathy 5?",
    "seeds": [
      "Centronuclear myopathy 5"
    ],
    "gold_answer": "Mitral regurgitation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11199",
    "question": "What is associated with Reduced residual volume?",
    "seeds": [
      "Reduced residual volume"
    ],
    "gold_answer": "Abnormal residual volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11200",
    "question": "What is associated with Mitochondrial DNA-related cardiomyopathy and hearing loss?",
    "seeds": [
      "Mitochondrial DNA-related cardiomyopathy and hearing loss"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11201",
    "question": "What is associated with Compensated hemolytic anemia?",
    "seeds": [
      "Compensated hemolytic anemia"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11202",
    "question": "What is associated with APUdoma?",
    "seeds": [
      "APUdoma"
    ],
    "gold_answer": "Neoplasm of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11203",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 11?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 11"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11204",
    "question": "What is associated with Mitochondrial complex IV deficiency, nuclear type 3?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 3"
    ],
    "gold_answer": "Visceromegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11205",
    "question": "What is associated with Abnormal epiphysis morphology?",
    "seeds": [
      "Abnormal epiphysis morphology"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11206",
    "question": "What is associated with Abnormality of the epiphysis of the proximal phalanx of the 3rd toe?",
    "seeds": [
      "Abnormality of the epiphysis of the proximal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal third toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11207",
    "question": "What is associated with X-linked hypohidrotic ectodermal dysplasia?",
    "seeds": [
      "X-linked hypohidrotic ectodermal dysplasia"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11208",
    "question": "What is associated with Osteochondromyxoma?",
    "seeds": [
      "Osteochondromyxoma"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11209",
    "question": "What is associated with Congenital facial diplegia?",
    "seeds": [
      "Congenital facial diplegia"
    ],
    "gold_answer": "Facial palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11210",
    "question": "What is associated with Elevanted carboxysterol concentration in cultured lymphoblasts?",
    "seeds": [
      "Elevanted carboxysterol concentration in cultured lymphoblasts"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11211",
    "question": "What phenotype is associated with Ulerythema ophryogenesis?",
    "seeds": [
      "Ulerythema ophryogenesis"
    ],
    "gold_answer": "Abnormality of the chin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11212",
    "question": "What is associated with Riboflavin deficiency?",
    "seeds": [
      "Riboflavin deficiency"
    ],
    "gold_answer": "Abnormal circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11213",
    "question": "What is associated with Absent ossification of calvaria?",
    "seeds": [
      "Absent ossification of calvaria"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11214",
    "question": "What is associated with Intestinal inflammation?",
    "seeds": [
      "Intestinal inflammation"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11215",
    "question": "What is associated with Cerebellar hypoplasia-tapetoretinal degeneration syndrome?",
    "seeds": [
      "Cerebellar hypoplasia-tapetoretinal degeneration syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11216",
    "question": "What is associated with Defective B cell differentiation?",
    "seeds": [
      "Defective B cell differentiation"
    ],
    "gold_answer": "Abnormal B cell physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11217",
    "question": "What phenotype is associated with Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria"
    ],
    "gold_answer": "Methylmalonic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11218",
    "question": "What phenotype is associated with Spondylometaphyseal dysplasia with cone-rod dystrophy?",
    "seeds": [
      "Spondylometaphyseal dysplasia with cone-rod dystrophy"
    ],
    "gold_answer": "Postnatal growth retardation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11219",
    "question": "What is associated with Multiple small vertebral fractures?",
    "seeds": [
      "Multiple small vertebral fractures"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11220",
    "question": "What is associated with Increased LH response to gonadotropin-releasing hormone stimulation test?",
    "seeds": [
      "Increased LH response to gonadotropin-releasing hormone stimulation test"
    ],
    "gold_answer": "Abnormal response to endocrine stimulation test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11221",
    "question": "What is associated with Elevated circulating carcinoma antigen 125 concentration?",
    "seeds": [
      "Elevated circulating carcinoma antigen 125 concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11222",
    "question": "What is associated with Fractured forearm bone?",
    "seeds": [
      "Fractured forearm bone"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11223",
    "question": "What is associated with Rib osteolysis?",
    "seeds": [
      "Rib osteolysis"
    ],
    "gold_answer": "Osteolysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11224",
    "question": "What is associated with Otosclerosis 12?",
    "seeds": [
      "Otosclerosis 12"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11225",
    "question": "What is associated with Synostosis involving the elbow?",
    "seeds": [
      "Synostosis involving the elbow"
    ],
    "gold_answer": "Synostosis of joints",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11226",
    "question": "What is associated with Decreased circulating 17-hydroxyprogesterone concentration?",
    "seeds": [
      "Decreased circulating 17-hydroxyprogesterone concentration"
    ],
    "gold_answer": "Decreased circulating progesterone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11227",
    "question": "What is associated with Autosomal recessive methemoglobinemia?",
    "seeds": [
      "Autosomal recessive methemoglobinemia"
    ],
    "gold_answer": "Esodeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11228",
    "question": "What is associated with Decreased circulating ferritin concentration?",
    "seeds": [
      "Decreased circulating ferritin concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11229",
    "question": "What is associated with First dorsal interossei muscle atrophy?",
    "seeds": [
      "First dorsal interossei muscle atrophy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11230",
    "question": "What is associated with Abnormal visual electrophysiology?",
    "seeds": [
      "Abnormal visual electrophysiology"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11231",
    "question": "What phenotype is associated with Neurodevelopmental disorder with language impairment, autism, and attention deficit-hyperactivity disorder?",
    "seeds": [
      "Neurodevelopmental disorder with language impairment, autism, and attention deficit-hyperactivity disorder"
    ],
    "gold_answer": "Thin upper lip vermilion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11232",
    "question": "What phenotype is associated with Vitamin K antagonist embryofetopathy?",
    "seeds": [
      "Vitamin K antagonist embryofetopathy"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11233",
    "question": "What is associated with Hyperphenylalaninemia, bh4-deficient, C?",
    "seeds": [
      "Hyperphenylalaninemia, bh4-deficient, C"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11234",
    "question": "What is associated with Cleft lip/palate-deafness-sacral lipoma syndrome?",
    "seeds": [
      "Cleft lip/palate-deafness-sacral lipoma syndrome"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11235",
    "question": "What is associated with Abnormal lacrimal gland morphology?",
    "seeds": [
      "Abnormal lacrimal gland morphology"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11236",
    "question": "What is associated with White forelock with malformations?",
    "seeds": [
      "White forelock with malformations"
    ],
    "gold_answer": "Abnormality of skeletal maturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11237",
    "question": "What is associated with FANCONI ANEMIA, COMPLEMENTATION GROUP U?",
    "seeds": [
      "FANCONI ANEMIA, COMPLEMENTATION GROUP U"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11238",
    "question": "What is associated with Advanced sleep phase syndrome, familial, 1?",
    "seeds": [
      "Advanced sleep phase syndrome, familial, 1"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11239",
    "question": "What phenotype is associated with Bardet-Biedl syndrome 16?",
    "seeds": [
      "Bardet-Biedl syndrome 16"
    ],
    "gold_answer": "Ureteral atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11240",
    "question": "What is associated with Sclerosis of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Sclerosis of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11241",
    "question": "What is associated with Mixed cirrhosis?",
    "seeds": [
      "Mixed cirrhosis"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11242",
    "question": "What phenotype is associated with Lissencephaly 8?",
    "seeds": [
      "Lissencephaly 8"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11243",
    "question": "What is associated with Congenital blindness?",
    "seeds": [
      "Congenital blindness"
    ],
    "gold_answer": "Blindness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11244",
    "question": "What is associated with Reduced respiratory ciliary beating frequency?",
    "seeds": [
      "Reduced respiratory ciliary beating frequency"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11245",
    "question": "What is associated with Increased CSF tryptophan concentration?",
    "seeds": [
      "Increased CSF tryptophan concentration"
    ],
    "gold_answer": "Abnormal CSF tryptophan concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11246",
    "question": "What is associated with Corneal guttata?",
    "seeds": [
      "Corneal guttata"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11247",
    "question": "What is associated with Malalignment of the great toenail?",
    "seeds": [
      "Malalignment of the great toenail"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11248",
    "question": "What is associated with Ehlers-Danlos syndrome, spondylodysplastic type, 2?",
    "seeds": [
      "Ehlers-Danlos syndrome, spondylodysplastic type, 2"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11249",
    "question": "What is associated with Irregular ossification at anterior rib ends?",
    "seeds": [
      "Irregular ossification at anterior rib ends"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11250",
    "question": "What phenotype is associated with Chromosome 16p12.2-p11.2 deletion syndrome, 7.1- to 8.7-mb?",
    "seeds": [
      "Chromosome 16p12.2-p11.2 deletion syndrome, 7.1- to 8.7-mb"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11251",
    "question": "What is associated with Mild receptive language delay?",
    "seeds": [
      "Mild receptive language delay"
    ],
    "gold_answer": "Receptive language delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11252",
    "question": "What is associated with Abnormality of humoral immunity?",
    "seeds": [
      "Abnormality of humoral immunity"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11253",
    "question": "What is associated with Hypermethioninemia due to adenosine kinase deficiency?",
    "seeds": [
      "Hypermethioninemia due to adenosine kinase deficiency"
    ],
    "gold_answer": "GATA6",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_11254",
    "question": "What phenotype is associated with Idiopathic hypersomnia?",
    "seeds": [
      "Idiopathic hypersomnia"
    ],
    "gold_answer": "Hypnopompic hallucinations",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11255",
    "question": "What is associated with Parkinson disease 15, autosomal recessive early-onset?",
    "seeds": [
      "Parkinson disease 15, autosomal recessive early-onset"
    ],
    "gold_answer": "Appendicular spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11256",
    "question": "What is associated with Impairment of the reflex of the tensor tympani muscle?",
    "seeds": [
      "Impairment of the reflex of the tensor tympani muscle"
    ],
    "gold_answer": "Abnormality of the reflex of the tensor tympani muscle",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11257",
    "question": "What is associated with Mediastinal mass?",
    "seeds": [
      "Mediastinal mass"
    ],
    "gold_answer": "Mass on thoracic imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11258",
    "question": "What is associated with Progressive hypotonia-intellectual disability-facial dysmorphism syndrome due to FYVE-defective RBSN?",
    "seeds": [
      "Progressive hypotonia-intellectual disability-facial dysmorphism syndrome due to FYVE-defective RBSN"
    ],
    "gold_answer": "RBSN",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_11259",
    "question": "What is associated with Elevated brain choline level by MRS?",
    "seeds": [
      "Elevated brain choline level by MRS"
    ],
    "gold_answer": "Abnormal brain choline level by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11260",
    "question": "What is associated with Alveolar process hypoplasia?",
    "seeds": [
      "Alveolar process hypoplasia"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11261",
    "question": "What phenotype is associated with Spermatogenic failure 64?",
    "seeds": [
      "Spermatogenic failure 64"
    ],
    "gold_answer": "Abnormal sperm head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11262",
    "question": "What is associated with Elevated urine 3-hydroxyglutaric level?",
    "seeds": [
      "Elevated urine 3-hydroxyglutaric level"
    ],
    "gold_answer": "Organic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11263",
    "question": "What is associated with Discrete 2 to 5-mm hyper- and hypopigmented macules?",
    "seeds": [
      "Discrete 2 to 5-mm hyper- and hypopigmented macules"
    ],
    "gold_answer": "Hyperpigmented/hypopigmented macules",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11264",
    "question": "What phenotype is associated with Congenital anomalies of kidney and urinary tract 2?",
    "seeds": [
      "Congenital anomalies of kidney and urinary tract 2"
    ],
    "gold_answer": "Renal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11265",
    "question": "What is associated with Reduced succinyl-CoA:3-oxoacid-CoA transferase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced succinyl-CoA:3-oxoacid-CoA transferase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11266",
    "question": "What is associated with Distortion of the anterior part of the interhemispheric fissure?",
    "seeds": [
      "Distortion of the anterior part of the interhemispheric fissure"
    ],
    "gold_answer": "Abnormal subarachnoid space morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11267",
    "question": "What is associated with Mitochondrial complex IV deficiency, nuclear type 20?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 20"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11268",
    "question": "What is associated with Drug-sensitive hemolytic anemia?",
    "seeds": [
      "Drug-sensitive hemolytic anemia"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11269",
    "question": "What is associated with Duplicated collecting system?",
    "seeds": [
      "Duplicated collecting system"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11270",
    "question": "What is associated with Fibular deviation of the 4th toe?",
    "seeds": [
      "Fibular deviation of the 4th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11271",
    "question": "What is associated with Mucolipidosis III gamma?",
    "seeds": [
      "Mucolipidosis III gamma"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11272",
    "question": "What is associated with Aphalangia, partial, with syndactyly and duplication of metatarsaliv?",
    "seeds": [
      "Aphalangia, partial, with syndactyly and duplication of metatarsaliv"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11273",
    "question": "What phenotype is associated with Melanoma, malignant familial intraocular?",
    "seeds": [
      "Melanoma, malignant familial intraocular"
    ],
    "gold_answer": "Uveal melanoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11274",
    "question": "What is associated with Reduced circulating acetylcarnitine concentration?",
    "seeds": [
      "Reduced circulating acetylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11275",
    "question": "What is associated with Spastic paraplegia 42, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 42, autosomal dominant"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11276",
    "question": "What is associated with Cortical radial artery neutrophil hypercellularity?",
    "seeds": [
      "Cortical radial artery neutrophil hypercellularity"
    ],
    "gold_answer": "Cortical radial artery leukocyte hypercellularity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11277",
    "question": "What phenotype is associated with Spermatogenic failure 74?",
    "seeds": [
      "Spermatogenic failure 74"
    ],
    "gold_answer": "Male infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11278",
    "question": "What is associated with Abnormal metatarsal morphology?",
    "seeds": [
      "Abnormal metatarsal morphology"
    ],
    "gold_answer": "Abnormality of limb bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11279",
    "question": "What is associated with 3M syndrome?",
    "seeds": [
      "3M syndrome"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11280",
    "question": "What phenotype is associated with Congenital herpes simplex virus infection?",
    "seeds": [
      "Congenital herpes simplex virus infection"
    ],
    "gold_answer": "Intrauterine growth retardation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11281",
    "question": "What is associated with Idiopathic intracranial hypertension?",
    "seeds": [
      "Idiopathic intracranial hypertension"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11282",
    "question": "What is associated with Absent muscle fiber beta sarcoglycan?",
    "seeds": [
      "Absent muscle fiber beta sarcoglycan"
    ],
    "gold_answer": "Abnormal muscle fiber protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11283",
    "question": "What is associated with Congenital short QT syndrome?",
    "seeds": [
      "Congenital short QT syndrome"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11284",
    "question": "What is associated with Adams-Oliver syndrome 1?",
    "seeds": [
      "Adams-Oliver syndrome 1"
    ],
    "gold_answer": "Elevated pulmonary artery pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11285",
    "question": "What is associated with Tenesmus?",
    "seeds": [
      "Tenesmus"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11286",
    "question": "What is associated with Neuroepithelial neoplasm?",
    "seeds": [
      "Neuroepithelial neoplasm"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11287",
    "question": "What phenotype is associated with Marbach-Schaaf neurodevelopmental syndrome?",
    "seeds": [
      "Marbach-Schaaf neurodevelopmental syndrome"
    ],
    "gold_answer": "Hemidystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11288",
    "question": "What is associated with Irregularly shaped lymph node germinal centers?",
    "seeds": [
      "Irregularly shaped lymph node germinal centers"
    ],
    "gold_answer": "Abnormal lymph-node germinal center morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11289",
    "question": "What is associated with Meconium pseudocyst?",
    "seeds": [
      "Meconium pseudocyst"
    ],
    "gold_answer": "Abnormal fetal gastrointestinal system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11290",
    "question": "What is associated with Femoral bowing?",
    "seeds": [
      "Femoral bowing"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11291",
    "question": "What is associated with Long nose?",
    "seeds": [
      "Long nose"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11292",
    "question": "What is associated with Pain at the medial aspect of the elbow?",
    "seeds": [
      "Pain at the medial aspect of the elbow"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11293",
    "question": "What phenotype is associated with Angelman syndrome?",
    "seeds": [
      "Angelman syndrome"
    ],
    "gold_answer": "Generalized hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11294",
    "question": "What phenotype is associated with Craniosynostosis 1?",
    "seeds": [
      "Craniosynostosis 1"
    ],
    "gold_answer": "Right unicoronal synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11295",
    "question": "What phenotype is associated with Short stature, hearing loss, retinitis pigmentosa, and distinctive facies?",
    "seeds": [
      "Short stature, hearing loss, retinitis pigmentosa, and distinctive facies"
    ],
    "gold_answer": "Long philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11296",
    "question": "What is associated with 10-minute APGAR score of 0?",
    "seeds": [
      "10-minute APGAR score of 0"
    ],
    "gold_answer": "Low APGAR score",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11297",
    "question": "What is associated with Abnormal blood transition element cation concentration?",
    "seeds": [
      "Abnormal blood transition element cation concentration"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11298",
    "question": "What is associated with Four-vessel umbilical cord?",
    "seeds": [
      "Four-vessel umbilical cord"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11299",
    "question": "What phenotype is associated with Severe combined immunodeficiency, X-linked?",
    "seeds": [
      "Severe combined immunodeficiency, X-linked"
    ],
    "gold_answer": "Abnormal fingernail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11300",
    "question": "What phenotype is associated with Growth hormone deficiency, isolated, type IA?",
    "seeds": [
      "Growth hormone deficiency, isolated, type IA"
    ],
    "gold_answer": "Persistent open anterior fontanelle",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11301",
    "question": "What is associated with Violet lip discoloration?",
    "seeds": [
      "Violet lip discoloration"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11302",
    "question": "What is associated with Abnormal interest?",
    "seeds": [
      "Abnormal interest"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11303",
    "question": "What is associated with Ulnar deviation of thumb?",
    "seeds": [
      "Ulnar deviation of thumb"
    ],
    "gold_answer": "Deviation of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11304",
    "question": "What is associated with Duplication of middle phalanx of toe?",
    "seeds": [
      "Duplication of middle phalanx of toe"
    ],
    "gold_answer": "Abnormality of the middle phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11305",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 64?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 64"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11306",
    "question": "What is associated with Pleural mesothelioma?",
    "seeds": [
      "Pleural mesothelioma"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11307",
    "question": "What is associated with Increased total basophil count?",
    "seeds": [
      "Increased total basophil count"
    ],
    "gold_answer": "Abnormal total basophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11308",
    "question": "What is associated with Progressive spinal muscular atrophy?",
    "seeds": [
      "Progressive spinal muscular atrophy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11309",
    "question": "What is associated with Focal impaired awareness sensory seizure with gustatory features?",
    "seeds": [
      "Focal impaired awareness sensory seizure with gustatory features"
    ],
    "gold_answer": "Focal impaired awareness sensory seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11310",
    "question": "What is associated with Fractured epiphysis of second metacarpal bone?",
    "seeds": [
      "Fractured epiphysis of second metacarpal bone"
    ],
    "gold_answer": "Fractured epiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11311",
    "question": "What is associated with Intrarenal reflux?",
    "seeds": [
      "Intrarenal reflux"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11312",
    "question": "What phenotype is associated with Multiple endocrine neoplasia type 1?",
    "seeds": [
      "Multiple endocrine neoplasia type 1"
    ],
    "gold_answer": "Pituitary hypothyroidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11313",
    "question": "What is associated with Unaided visual acuity 0.4 LogMAR?",
    "seeds": [
      "Unaided visual acuity 0.4 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11314",
    "question": "What is associated with Perivascular small intestinal hyaline deposition?",
    "seeds": [
      "Perivascular small intestinal hyaline deposition"
    ],
    "gold_answer": "Abnormal small intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11315",
    "question": "What is associated with Enlarged humeral metaphyses?",
    "seeds": [
      "Enlarged humeral metaphyses"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11316",
    "question": "What is associated with Adenylosuccinase deficiency?",
    "seeds": [
      "Adenylosuccinase deficiency"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11317",
    "question": "What is associated with Splenic hemophagocytosis?",
    "seeds": [
      "Splenic hemophagocytosis"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11318",
    "question": "What is associated with Necrotizing pulmonary granulomatosis?",
    "seeds": [
      "Necrotizing pulmonary granulomatosis"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11319",
    "question": "What is associated with Humeral metaphyseal irregularity?",
    "seeds": [
      "Humeral metaphyseal irregularity"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11320",
    "question": "What is associated with Avoidance of emotional intimacy?",
    "seeds": [
      "Avoidance of emotional intimacy"
    ],
    "gold_answer": "Abnormal social development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11321",
    "question": "What is associated with Bullet-shaped distal phalanx of the 3rd finger?",
    "seeds": [
      "Bullet-shaped distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11322",
    "question": "What is associated with S-shaped palpebral fissures?",
    "seeds": [
      "S-shaped palpebral fissures"
    ],
    "gold_answer": "Abnormal shape of the palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11323",
    "question": "What is associated with Enlarged epiphysis of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Enlarged epiphysis of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11324",
    "question": "What is associated with Extremities cold to touch?",
    "seeds": [
      "Extremities cold to touch"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11325",
    "question": "What phenotype is associated with Ige responsiveness, atopic?",
    "seeds": [
      "Ige responsiveness, atopic"
    ],
    "gold_answer": "Allergic rhinitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11326",
    "question": "What is associated with Stage 3 chronic kidney disease?",
    "seeds": [
      "Stage 3 chronic kidney disease"
    ],
    "gold_answer": "Renal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11327",
    "question": "What is associated with Focal emotional seizure with crying?",
    "seeds": [
      "Focal emotional seizure with crying"
    ],
    "gold_answer": "Focal emotional seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11328",
    "question": "What is associated with Osteolytic defects of the distal phalanges of the toes?",
    "seeds": [
      "Osteolytic defects of the distal phalanges of the toes"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11329",
    "question": "What is associated with Dilation of Virchow-Robin spaces?",
    "seeds": [
      "Dilation of Virchow-Robin spaces"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11330",
    "question": "What phenotype is associated with 3-M syndrome 1?",
    "seeds": [
      "3-M syndrome 1"
    ],
    "gold_answer": "Small for gestational age",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11331",
    "question": "What is associated with Abnormality of central retinal artery?",
    "seeds": [
      "Abnormality of central retinal artery"
    ],
    "gold_answer": "Abnormal internal carotid artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11332",
    "question": "What is associated with Alkalemia?",
    "seeds": [
      "Alkalemia"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11333",
    "question": "What phenotype is associated with Ichthyosis, congenital, autosomal recessive 5?",
    "seeds": [
      "Ichthyosis, congenital, autosomal recessive 5"
    ],
    "gold_answer": "Palmar hyperlinearity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11334",
    "question": "What phenotype is associated with Cataract 33, multiple types?",
    "seeds": [
      "Cataract 33, multiple types"
    ],
    "gold_answer": "Nuclear cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11335",
    "question": "What phenotype is associated with Seckel syndrome 6?",
    "seeds": [
      "Seckel syndrome 6"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11336",
    "question": "What is associated with Anomalous origin of left coronary artery from the pulmonary artery?",
    "seeds": [
      "Anomalous origin of left coronary artery from the pulmonary artery"
    ],
    "gold_answer": "Abnormal coronary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11337",
    "question": "What is associated with Developmental delay-immunodeficiency-leukoencephalopathy-hypohomocysteinemia syndrome?",
    "seeds": [
      "Developmental delay-immunodeficiency-leukoencephalopathy-hypohomocysteinemia syndrome"
    ],
    "gold_answer": "NFE2L2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_11338",
    "question": "What is associated with Lethal faciocardiomelic dysplasia?",
    "seeds": [
      "Lethal faciocardiomelic dysplasia"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11339",
    "question": "What is associated with Brachydactyly, type C?",
    "seeds": [
      "Brachydactyly, type C"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11340",
    "question": "What is associated with Nonaka myopathy?",
    "seeds": [
      "Nonaka myopathy"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11341",
    "question": "What is associated with Transient nephrotic syndrome?",
    "seeds": [
      "Transient nephrotic syndrome"
    ],
    "gold_answer": "Nephrotic syndrome",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11342",
    "question": "What is associated with Aphalangy-hemivertebrae-urogenital-intestinal dysgenesis syndrome?",
    "seeds": [
      "Aphalangy-hemivertebrae-urogenital-intestinal dysgenesis syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the lungs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11343",
    "question": "What is associated with Abnormal forebrain morphology?",
    "seeds": [
      "Abnormal forebrain morphology"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11344",
    "question": "What is associated with Axonal degeneration/regeneration?",
    "seeds": [
      "Axonal degeneration/regeneration"
    ],
    "gold_answer": "Peripheral axonal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11345",
    "question": "What is associated with Decreased thalamic volume?",
    "seeds": [
      "Decreased thalamic volume"
    ],
    "gold_answer": "Abnormal thalamus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11346",
    "question": "What is associated with Anorectal abscess?",
    "seeds": [
      "Anorectal abscess"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11347",
    "question": "What is associated with Reduced contrast sensitivity?",
    "seeds": [
      "Reduced contrast sensitivity"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11348",
    "question": "What phenotype is associated with Noonan syndrome 2?",
    "seeds": [
      "Noonan syndrome 2"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11349",
    "question": "What is associated with Axenfeld-Rieger syndrome, type 3?",
    "seeds": [
      "Axenfeld-Rieger syndrome, type 3"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11350",
    "question": "What phenotype is associated with Ichthyosis, lamellar, autosomal dominant?",
    "seeds": [
      "Ichthyosis, lamellar, autosomal dominant"
    ],
    "gold_answer": "Pruritus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11351",
    "question": "What is associated with Osteoblastoma?",
    "seeds": [
      "Osteoblastoma"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11352",
    "question": "What phenotype is associated with Wilms tumor 1?",
    "seeds": [
      "Wilms tumor 1"
    ],
    "gold_answer": "Nephroblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11353",
    "question": "What is associated with Reduced platelet dense granules?",
    "seeds": [
      "Reduced platelet dense granules"
    ],
    "gold_answer": "Abnormal platelet granules",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11354",
    "question": "What is associated with Neonatal seizure with bilateral symmetric automatism?",
    "seeds": [
      "Neonatal seizure with bilateral symmetric automatism"
    ],
    "gold_answer": "Neonatal electro-clinical motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11355",
    "question": "What phenotype is associated with X-linked Charcot-Marie-Tooth disease type 3?",
    "seeds": [
      "X-linked Charcot-Marie-Tooth disease type 3"
    ],
    "gold_answer": "Inability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11356",
    "question": "What is associated with Abnormal buccal fat pad morphology?",
    "seeds": [
      "Abnormal buccal fat pad morphology"
    ],
    "gold_answer": "Abnormal midface morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11357",
    "question": "What is associated with Cubitus valgus?",
    "seeds": [
      "Cubitus valgus"
    ],
    "gold_answer": "Abnormal elbow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11358",
    "question": "What is associated with Abnormal electrooculogram?",
    "seeds": [
      "Abnormal electrooculogram"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11359",
    "question": "What is associated with Sclerosis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Sclerosis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Sclerosis of 2nd toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11360",
    "question": "What is associated with Tendon pain?",
    "seeds": [
      "Tendon pain"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11361",
    "question": "What is associated with Intellectual disability-short stature-hypertelorism syndrome?",
    "seeds": [
      "Intellectual disability-short stature-hypertelorism syndrome"
    ],
    "gold_answer": "Abnormal frontal bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11362",
    "question": "What is associated with Increased circulating creatine kinase MM isoform?",
    "seeds": [
      "Increased circulating creatine kinase MM isoform"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11363",
    "question": "What is associated with Cutis laxa, autosomal recessive, type IID?",
    "seeds": [
      "Cutis laxa, autosomal recessive, type IID"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11364",
    "question": "What is associated with Angel-shaped phalanx?",
    "seeds": [
      "Angel-shaped phalanx"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11365",
    "question": "What is associated with Positive cutaneous herpes simplex virus nucleic acid test?",
    "seeds": [
      "Positive cutaneous herpes simplex virus nucleic acid test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11366",
    "question": "What is associated with Transcobalamin I deficiency?",
    "seeds": [
      "Transcobalamin I deficiency"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11367",
    "question": "What phenotype is associated with IMAGe syndrome?",
    "seeds": [
      "IMAGe syndrome"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11368",
    "question": "What is associated with Reduced tissue galactocerebrosidase activity?",
    "seeds": [
      "Reduced tissue galactocerebrosidase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11369",
    "question": "What is associated with Nevoid hypermelanosis, linear and whorled?",
    "seeds": [
      "Nevoid hypermelanosis, linear and whorled"
    ],
    "gold_answer": "Abnormal granulocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11370",
    "question": "What is associated with Pulmonary fibrosis, idiopathic?",
    "seeds": [
      "Pulmonary fibrosis, idiopathic"
    ],
    "gold_answer": "Abnormal DLCO",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11371",
    "question": "What is associated with Pulmonary edema?",
    "seeds": [
      "Pulmonary edema"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11372",
    "question": "What is associated with Erythematous plaque?",
    "seeds": [
      "Erythematous plaque"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11373",
    "question": "What is associated with Unaided visual acuity 3.0 LogMAR?",
    "seeds": [
      "Unaided visual acuity 3.0 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11374",
    "question": "What phenotype is associated with Hydatidiform mole, recurrent, 2?",
    "seeds": [
      "Hydatidiform mole, recurrent, 2"
    ],
    "gold_answer": "Hydatidiform mole",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11375",
    "question": "What is associated with Absent muscle fiber emerin?",
    "seeds": [
      "Absent muscle fiber emerin"
    ],
    "gold_answer": "Abnormal muscle fiber emerin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11376",
    "question": "What is associated with Reduced tissue neuraminidase activity?",
    "seeds": [
      "Reduced tissue neuraminidase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11377",
    "question": "What is associated with Elevated urinary 3-hydroxypentanoic acid level?",
    "seeds": [
      "Elevated urinary 3-hydroxypentanoic acid level"
    ],
    "gold_answer": "Monocarboxylic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11378",
    "question": "What is associated with Aplasia/Hypoplasia of the thyroid gland?",
    "seeds": [
      "Aplasia/Hypoplasia of the thyroid gland"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11379",
    "question": "What is associated with Gracile bone dysplasia?",
    "seeds": [
      "Gracile bone dysplasia"
    ],
    "gold_answer": "Abnormal penis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11380",
    "question": "What is associated with Auditory neuropathy, autosomal dominant 2?",
    "seeds": [
      "Auditory neuropathy, autosomal dominant 2"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11381",
    "question": "What is associated with Peters plus syndrome?",
    "seeds": [
      "Peters plus syndrome"
    ],
    "gold_answer": "Abnormal renal pelvis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11382",
    "question": "What is associated with Pseudoepiphysis of the proximal phalanx of the hallux?",
    "seeds": [
      "Pseudoepiphysis of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Pseudoepiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11383",
    "question": "What is associated with Fragmented epiphyses?",
    "seeds": [
      "Fragmented epiphyses"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11384",
    "question": "What is associated with Ichthyosis, congenital, autosomal recessive 11?",
    "seeds": [
      "Ichthyosis, congenital, autosomal recessive 11"
    ],
    "gold_answer": "Abnormality of hair texture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11385",
    "question": "What phenotype is associated with Ullrich congenital muscular dystrophy 1B?",
    "seeds": [
      "Ullrich congenital muscular dystrophy 1B"
    ],
    "gold_answer": "Kyphosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11386",
    "question": "What is associated with Auricular pit?",
    "seeds": [
      "Auricular pit"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11387",
    "question": "What is associated with Fragile site 16q22?",
    "seeds": [
      "Fragile site 16q22"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11388",
    "question": "What is associated with Absent tragus?",
    "seeds": [
      "Absent tragus"
    ],
    "gold_answer": "Abnormal tragus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11389",
    "question": "What is associated with Megaloblastic anemia?",
    "seeds": [
      "Megaloblastic anemia"
    ],
    "gold_answer": "Macrocytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11390",
    "question": "What phenotype is associated with Epilepsy, juvenile absence?",
    "seeds": [
      "Epilepsy, juvenile absence"
    ],
    "gold_answer": "Generalized myoclonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11391",
    "question": "What is associated with Postaxial polysyndactyly of foot?",
    "seeds": [
      "Postaxial polysyndactyly of foot"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11392",
    "question": "What is associated with Chronic mucocutaneous candidiasis?",
    "seeds": [
      "Chronic mucocutaneous candidiasis"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11393",
    "question": "What is associated with Myopathic Ehlers-Danlos syndrome?",
    "seeds": [
      "Myopathic Ehlers-Danlos syndrome"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11394",
    "question": "What is associated with Foveal intraretinal hyporeflective spaces on macular OCT?",
    "seeds": [
      "Foveal intraretinal hyporeflective spaces on macular OCT"
    ],
    "gold_answer": "Foveal hyporeflective spaces on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11395",
    "question": "What phenotype is associated with Hypermethioninemia due to adenosine kinase deficiency?",
    "seeds": [
      "Hypermethioninemia due to adenosine kinase deficiency"
    ],
    "gold_answer": "Poor speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11396",
    "question": "What is associated with Curved 1st metatarsal?",
    "seeds": [
      "Curved 1st metatarsal"
    ],
    "gold_answer": "Abnormality of the first metatarsal bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11397",
    "question": "What is associated with Cerebral calcification?",
    "seeds": [
      "Cerebral calcification"
    ],
    "gold_answer": "Ectopic calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11398",
    "question": "What is associated with Arteriovenous fistula?",
    "seeds": [
      "Arteriovenous fistula"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11399",
    "question": "What is associated with Elevated circulating C-triol concentration?",
    "seeds": [
      "Elevated circulating C-triol concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11400",
    "question": "What is associated with Elevated urinary dolichol level?",
    "seeds": [
      "Elevated urinary dolichol level"
    ],
    "gold_answer": "Abnormal urinary organic compound level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11401",
    "question": "What is associated with Abnormal urine cytology?",
    "seeds": [
      "Abnormal urine cytology"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11402",
    "question": "What is associated with Accessory scaphoid?",
    "seeds": [
      "Accessory scaphoid"
    ],
    "gold_answer": "Abnormal carpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11403",
    "question": "What is associated with Abdominal obesity-metabolic syndrome 1?",
    "seeds": [
      "Abdominal obesity-metabolic syndrome 1"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11404",
    "question": "What phenotype is associated with Metaphyseal chondrodysplasia, Spahr type?",
    "seeds": [
      "Metaphyseal chondrodysplasia, Spahr type"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11405",
    "question": "What is associated with Cervical vertebral facet hypoplasia?",
    "seeds": [
      "Cervical vertebral facet hypoplasia"
    ],
    "gold_answer": "Abnormality of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11406",
    "question": "What is associated with Reduced epidermal keratin protein expression?",
    "seeds": [
      "Reduced epidermal keratin protein expression"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11407",
    "question": "What is associated with Monoclonal elevation of IgG light chain?",
    "seeds": [
      "Monoclonal elevation of IgG light chain"
    ],
    "gold_answer": "Monoclonal elevation of IgG",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11408",
    "question": "What is associated with Irregular ossification of hand bones?",
    "seeds": [
      "Irregular ossification of hand bones"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11409",
    "question": "What is associated with Decreased naive CD4+ T cell proportion?",
    "seeds": [
      "Decreased naive CD4+ T cell proportion"
    ],
    "gold_answer": "Abnormal naive CD4+ T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11410",
    "question": "What is associated with Carotid artery dissection?",
    "seeds": [
      "Carotid artery dissection"
    ],
    "gold_answer": "Abnormal carotid artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11411",
    "question": "What is associated with Small posterior fossa?",
    "seeds": [
      "Small posterior fossa"
    ],
    "gold_answer": "Abnormal skull base morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11412",
    "question": "What is associated with Focal cognitive seizure with left-right confusion?",
    "seeds": [
      "Focal cognitive seizure with left-right confusion"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11413",
    "question": "What is associated with Motor seizure?",
    "seeds": [
      "Motor seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11414",
    "question": "What is associated with Eruptive vellus hair cyst?",
    "seeds": [
      "Eruptive vellus hair cyst"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11415",
    "question": "What is associated with Oculomaxillofacial dysostosis?",
    "seeds": [
      "Oculomaxillofacial dysostosis"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11416",
    "question": "What is associated with Cutaneous mastocytosis, conductive hearing loss, and microtia?",
    "seeds": [
      "Cutaneous mastocytosis, conductive hearing loss, and microtia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the external ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11417",
    "question": "What is associated with Fibular aplasia, tibial campomelia, and oligosyndactyly syndrome?",
    "seeds": [
      "Fibular aplasia, tibial campomelia, and oligosyndactyly syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11418",
    "question": "What is associated with Synostosis involving digits?",
    "seeds": [
      "Synostosis involving digits"
    ],
    "gold_answer": "Synostosis of joints",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11419",
    "question": "What is associated with Abnormal Humphrey SITA 10-2 perimetry test?",
    "seeds": [
      "Abnormal Humphrey SITA 10-2 perimetry test"
    ],
    "gold_answer": "Abnormal static perimetry test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11420",
    "question": "What is associated with Leukoencephalopathy, porphyria-related?",
    "seeds": [
      "Leukoencephalopathy, porphyria-related"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11421",
    "question": "What is associated with Depersonalization?",
    "seeds": [
      "Depersonalization"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11422",
    "question": "What phenotype is associated with Elliptocytosis 2?",
    "seeds": [
      "Elliptocytosis 2"
    ],
    "gold_answer": "Neonatal hyperbilirubinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11423",
    "question": "What is associated with Decreased Th17 T cell proportion?",
    "seeds": [
      "Decreased Th17 T cell proportion"
    ],
    "gold_answer": "Abnormal Th17 T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11424",
    "question": "What is associated with Synotia?",
    "seeds": [
      "Synotia"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11425",
    "question": "What is associated with Chronic rhinitis?",
    "seeds": [
      "Chronic rhinitis"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11426",
    "question": "What is associated with Calcified ovarian cyst?",
    "seeds": [
      "Calcified ovarian cyst"
    ],
    "gold_answer": "Abnormal ovarian morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11427",
    "question": "What phenotype is associated with Metaphyseal dysplasia with maxillary hypoplasia and brachydactyly?",
    "seeds": [
      "Metaphyseal dysplasia with maxillary hypoplasia and brachydactyly"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11428",
    "question": "What is associated with Exercise-induced muscle stiffness?",
    "seeds": [
      "Exercise-induced muscle stiffness"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11429",
    "question": "What is associated with Pfeiffer syndrome type 2?",
    "seeds": [
      "Pfeiffer syndrome type 2"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11430",
    "question": "What is associated with Upper-limb joint contracture?",
    "seeds": [
      "Upper-limb joint contracture"
    ],
    "gold_answer": "Abnormal tendon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11431",
    "question": "What is associated with Clubbing of fingers?",
    "seeds": [
      "Clubbing of fingers"
    ],
    "gold_answer": "Abnormal fingertip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11432",
    "question": "What is associated with Marfan syndrome type 2?",
    "seeds": [
      "Marfan syndrome type 2"
    ],
    "gold_answer": "TGFBR2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_11433",
    "question": "What is associated with Amelia involving the upper limbs?",
    "seeds": [
      "Amelia involving the upper limbs"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11434",
    "question": "What phenotype is associated with Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis?",
    "seeds": [
      "Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis"
    ],
    "gold_answer": "Dilated cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11435",
    "question": "What is associated with Glomerular endothelial tubuloreticular inclusion?",
    "seeds": [
      "Glomerular endothelial tubuloreticular inclusion"
    ],
    "gold_answer": "Abnormal glomerular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11436",
    "question": "What is associated with Shellfish allergy?",
    "seeds": [
      "Shellfish allergy"
    ],
    "gold_answer": "Seafood allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11437",
    "question": "What is associated with Osteoglosphonic dysplasia?",
    "seeds": [
      "Osteoglosphonic dysplasia"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11438",
    "question": "What phenotype is associated with Systemic lupus erythematosus 18?",
    "seeds": [
      "Systemic lupus erythematosus 18"
    ],
    "gold_answer": "Anorexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11439",
    "question": "What is associated with Asymmetric bilateral cleft lip?",
    "seeds": [
      "Asymmetric bilateral cleft lip"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11440",
    "question": "What is associated with Developmental and epileptic encephalopathy 26?",
    "seeds": [
      "Developmental and epileptic encephalopathy 26"
    ],
    "gold_answer": "Stereotypic upper-extremity movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11441",
    "question": "What is associated with Chromosome 13q14 deletion syndrome?",
    "seeds": [
      "Chromosome 13q14 deletion syndrome"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11442",
    "question": "What is associated with Superior pectus carinatum?",
    "seeds": [
      "Superior pectus carinatum"
    ],
    "gold_answer": "Abnormal sternum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11443",
    "question": "What is associated with Abnormal urine guanidinoacetic acid level?",
    "seeds": [
      "Abnormal urine guanidinoacetic acid level"
    ],
    "gold_answer": "Increased urine proteinogenic amino acid derivative level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11444",
    "question": "What is associated with Increased intraabdominal fat?",
    "seeds": [
      "Increased intraabdominal fat"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11445",
    "question": "What is associated with Prelingual sensorineural hearing impairment?",
    "seeds": [
      "Prelingual sensorineural hearing impairment"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11446",
    "question": "What is associated with Petechiae?",
    "seeds": [
      "Petechiae"
    ],
    "gold_answer": "Subcutaneous hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11447",
    "question": "What phenotype is associated with Simpson-Golabi-Behmel syndrome, type 1?",
    "seeds": [
      "Simpson-Golabi-Behmel syndrome, type 1"
    ],
    "gold_answer": "Corneal neovascularization",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11448",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 52?",
    "seeds": [
      "Ciliary dyskinesia, primary, 52"
    ],
    "gold_answer": "Ventricular septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11449",
    "question": "What is associated with Positive bloodstream VDRL test?",
    "seeds": [
      "Positive bloodstream VDRL test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11450",
    "question": "What is associated with Trismus?",
    "seeds": [
      "Trismus"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11451",
    "question": "What phenotype is associated with Hepatocellular carcinoma?",
    "seeds": [
      "Hepatocellular carcinoma"
    ],
    "gold_answer": "Subacute progressive viral hepatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11452",
    "question": "What is associated with Jaw contracture?",
    "seeds": [
      "Jaw contracture"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11453",
    "question": "What is associated with Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis?",
    "seeds": [
      "Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11454",
    "question": "What is associated with Aniridia-ptosis-intellectual disability-familial obesity syndrome?",
    "seeds": [
      "Aniridia-ptosis-intellectual disability-familial obesity syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia affecting the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11455",
    "question": "What is associated with Postmenopausal onset?",
    "seeds": [
      "Postmenopausal onset"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11456",
    "question": "What is associated with Snail-like ilia?",
    "seeds": [
      "Snail-like ilia"
    ],
    "gold_answer": "Abnormal ilium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11457",
    "question": "What is associated with Focal impaired awareness autonomic seizure with pallor/flushing?",
    "seeds": [
      "Focal impaired awareness autonomic seizure with pallor/flushing"
    ],
    "gold_answer": "Focal autonomic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11458",
    "question": "What is associated with Aplasia of the vestibule?",
    "seeds": [
      "Aplasia of the vestibule"
    ],
    "gold_answer": "Abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11459",
    "question": "What is associated with Pyknotic bone marrow neutrophils?",
    "seeds": [
      "Pyknotic bone marrow neutrophils"
    ],
    "gold_answer": "Abnormal granulocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11460",
    "question": "What is associated with Achilles tendon calcification?",
    "seeds": [
      "Achilles tendon calcification"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11461",
    "question": "What is associated with Pulmonary artery aneurysm?",
    "seeds": [
      "Pulmonary artery aneurysm"
    ],
    "gold_answer": "Abnormality of the pulmonary artery",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11462",
    "question": "What is associated with Reduced leukocyte alpha-L-fucosidase activity?",
    "seeds": [
      "Reduced leukocyte alpha-L-fucosidase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11463",
    "question": "What is associated with Coffin-Siris syndrome 5?",
    "seeds": [
      "Coffin-Siris syndrome 5"
    ],
    "gold_answer": "Thick vermilion border",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11464",
    "question": "What is associated with Cataract-hypertrichosis-intellectual disability syndrome?",
    "seeds": [
      "Cataract-hypertrichosis-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11465",
    "question": "What is associated with Abnormality of neutrophil morphology in CSF?",
    "seeds": [
      "Abnormality of neutrophil morphology in CSF"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11466",
    "question": "What is associated with Early infantile developmental and epileptic encephalopathy?",
    "seeds": [
      "Early infantile developmental and epileptic encephalopathy"
    ],
    "gold_answer": "Abnormal morphology of the nasal alae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11467",
    "question": "What is associated with Impaired renal tubular reabsorption of uric acid?",
    "seeds": [
      "Impaired renal tubular reabsorption of uric acid"
    ],
    "gold_answer": "Renal tubular dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11468",
    "question": "What is associated with Aplasia of the thymus?",
    "seeds": [
      "Aplasia of the thymus"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the thymus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11469",
    "question": "What is associated with Abnormal circulating amino acid concentration?",
    "seeds": [
      "Abnormal circulating amino acid concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11470",
    "question": "What is associated with Low placental alkaline phosphatase?",
    "seeds": [
      "Low placental alkaline phosphatase"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11471",
    "question": "What is associated with Arterial tortuosity-bone fragility syndrome?",
    "seeds": [
      "Arterial tortuosity-bone fragility syndrome"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11472",
    "question": "What is associated with Abnormal mandible coronoid process morphology?",
    "seeds": [
      "Abnormal mandible coronoid process morphology"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11473",
    "question": "What is associated with Chiari type II malformation?",
    "seeds": [
      "Chiari type II malformation"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11474",
    "question": "What is associated with Broad phalanges of the 3rd finger?",
    "seeds": [
      "Broad phalanges of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11475",
    "question": "What is associated with Abnormal Bowman capsule morphology?",
    "seeds": [
      "Abnormal Bowman capsule morphology"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11476",
    "question": "What is associated with Lethal acantholytic erosive disorder?",
    "seeds": [
      "Lethal acantholytic erosive disorder"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11477",
    "question": "What is associated with Intestinal ischemia?",
    "seeds": [
      "Intestinal ischemia"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11478",
    "question": "What phenotype is associated with Congenital myopathy 26?",
    "seeds": [
      "Congenital myopathy 26"
    ],
    "gold_answer": "Fiber type grouping",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11479",
    "question": "What is associated with Splayed epiphyses?",
    "seeds": [
      "Splayed epiphyses"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11480",
    "question": "What is associated with MENOPAUSE, NATURAL, AGE AT, QUANTITATIVE TRAIT LOCUS 1?",
    "seeds": [
      "MENOPAUSE, NATURAL, AGE AT, QUANTITATIVE TRAIT LOCUS 1"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11481",
    "question": "What is associated with Developmental glaucoma?",
    "seeds": [
      "Developmental glaucoma"
    ],
    "gold_answer": "Glaucoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11482",
    "question": "What is associated with Angioma serpentinum?",
    "seeds": [
      "Angioma serpentinum"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11483",
    "question": "What is associated with Foot asymmetry?",
    "seeds": [
      "Foot asymmetry"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11484",
    "question": "What is associated with Hypotonia-cystinuria syndrome?",
    "seeds": [
      "Hypotonia-cystinuria syndrome"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11485",
    "question": "What is associated with Attention deficit-hyperactivity disorder 8?",
    "seeds": [
      "Attention deficit-hyperactivity disorder 8"
    ],
    "gold_answer": "Hyperactivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11486",
    "question": "What is associated with Mucolipidosis type III?",
    "seeds": [
      "Mucolipidosis type III"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11487",
    "question": "What is associated with EEG with polyspike wave complexes?",
    "seeds": [
      "EEG with polyspike wave complexes"
    ],
    "gold_answer": "EEG with generalized epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11488",
    "question": "What is associated with Abnormal 3rd metacarpal epiphysis morphology?",
    "seeds": [
      "Abnormal 3rd metacarpal epiphysis morphology"
    ],
    "gold_answer": "Abnormal 3rd metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11489",
    "question": "What is associated with Martsolf syndrome 2?",
    "seeds": [
      "Martsolf syndrome 2"
    ],
    "gold_answer": "Flexion contracture of digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11490",
    "question": "What is associated with Hypermanganesemia?",
    "seeds": [
      "Hypermanganesemia"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11491",
    "question": "What is associated with Cutis gyrata of scalp?",
    "seeds": [
      "Cutis gyrata of scalp"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11492",
    "question": "What is associated with Decreased specific pneumococcal antibody level?",
    "seeds": [
      "Decreased specific pneumococcal antibody level"
    ],
    "gold_answer": "Decreased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11493",
    "question": "What is associated with Frailty?",
    "seeds": [
      "Frailty"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11494",
    "question": "What is associated with Stippling of the epiphysis of the 1st metatarsal?",
    "seeds": [
      "Stippling of the epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Abnormality of the epiphyses of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11495",
    "question": "What is associated with Hyperpigmented streaks?",
    "seeds": [
      "Hyperpigmented streaks"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11496",
    "question": "What is associated with Nemaline myopathy 3?",
    "seeds": [
      "Nemaline myopathy 3"
    ],
    "gold_answer": "Functional motor deficit",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11497",
    "question": "What is associated with Unaided visual acuity 3.0 LogMAR?",
    "seeds": [
      "Unaided visual acuity 3.0 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11498",
    "question": "What is associated with Hypothermia?",
    "seeds": [
      "Hypothermia"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11499",
    "question": "What is associated with Radial head fracture?",
    "seeds": [
      "Radial head fracture"
    ],
    "gold_answer": "Fractured radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11500",
    "question": "What is associated with Visual gaze preference?",
    "seeds": [
      "Visual gaze preference"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11501",
    "question": "What is associated with Fractured lower limb segment?",
    "seeds": [
      "Fractured lower limb segment"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11502",
    "question": "What is associated with Narrow femoral neck?",
    "seeds": [
      "Narrow femoral neck"
    ],
    "gold_answer": "Abnormal femoral neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11503",
    "question": "What is associated with Auroneurodental syndrome?",
    "seeds": [
      "Auroneurodental syndrome"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11504",
    "question": "What is associated with Abnormal urine amino acid level?",
    "seeds": [
      "Abnormal urine amino acid level"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11505",
    "question": "What phenotype is associated with Nephronophthisis 20?",
    "seeds": [
      "Nephronophthisis 20"
    ],
    "gold_answer": "Stage 5 chronic kidney disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11506",
    "question": "What is associated with Cupped ear?",
    "seeds": [
      "Cupped ear"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11507",
    "question": "What is associated with Mercury poisoning?",
    "seeds": [
      "Mercury poisoning"
    ],
    "gold_answer": "Respiratory insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11508",
    "question": "What is associated with Ameliorated by colchicine?",
    "seeds": [
      "Ameliorated by colchicine"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11509",
    "question": "What is associated with Increased fetal long bone echogenicity?",
    "seeds": [
      "Increased fetal long bone echogenicity"
    ],
    "gold_answer": "Abnormal fetal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11510",
    "question": "What is associated with Bartter syndrome, type 3?",
    "seeds": [
      "Bartter syndrome, type 3"
    ],
    "gold_answer": "Alkalosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11511",
    "question": "What is associated with Focal orofacial automatism seizure?",
    "seeds": [
      "Focal orofacial automatism seizure"
    ],
    "gold_answer": "Motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11512",
    "question": "What is associated with Geophagia?",
    "seeds": [
      "Geophagia"
    ],
    "gold_answer": "Abnormal consumption behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11513",
    "question": "What is associated with Supernumerary vertebral ossification centers?",
    "seeds": [
      "Supernumerary vertebral ossification centers"
    ],
    "gold_answer": "Abnormally ossified vertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11514",
    "question": "What is associated with Cerebral dysmyelination?",
    "seeds": [
      "Cerebral dysmyelination"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11515",
    "question": "What is associated with Spontaneous pain sensation?",
    "seeds": [
      "Spontaneous pain sensation"
    ],
    "gold_answer": "Abnormality of pain sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11516",
    "question": "What is associated with Tetralogy of Fallot with pulmonary atresia and major aortopulmonary collateral arteries?",
    "seeds": [
      "Tetralogy of Fallot with pulmonary atresia and major aortopulmonary collateral arteries"
    ],
    "gold_answer": "Tetralogy of Fallot with pulmonary atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11517",
    "question": "What is associated with Fibular aplasia-complex brachydactyly syndrome?",
    "seeds": [
      "Fibular aplasia-complex brachydactyly syndrome"
    ],
    "gold_answer": "Carpal synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11518",
    "question": "What phenotype is associated with Mucolipidosis IV?",
    "seeds": [
      "Mucolipidosis IV"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11519",
    "question": "What is associated with Pulmonary arterial atherosclerosis?",
    "seeds": [
      "Pulmonary arterial atherosclerosis"
    ],
    "gold_answer": "Abnormal pulmonary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11520",
    "question": "What is associated with Deformed rib cage?",
    "seeds": [
      "Deformed rib cage"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11521",
    "question": "What is associated with Spinal neurenteric cyst?",
    "seeds": [
      "Spinal neurenteric cyst"
    ],
    "gold_answer": "Central nervous system cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11522",
    "question": "What is associated with Glycine encephalopathy 2?",
    "seeds": [
      "Glycine encephalopathy 2"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11523",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2HH?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2HH"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11524",
    "question": "What is associated with Elevated circulating acetylcarnitine concentration?",
    "seeds": [
      "Elevated circulating acetylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11525",
    "question": "What is associated with Lissencephaly due to TUBA1A mutation?",
    "seeds": [
      "Lissencephaly due to TUBA1A mutation"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11526",
    "question": "What is associated with Abnormal circulating transferrin concentration?",
    "seeds": [
      "Abnormal circulating transferrin concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11527",
    "question": "What is associated with Auriculitis?",
    "seeds": [
      "Auriculitis"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11528",
    "question": "What is associated with Acquired schizencephaly?",
    "seeds": [
      "Acquired schizencephaly"
    ],
    "gold_answer": "SIX3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_11529",
    "question": "What is associated with Patchy sclerosis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Patchy sclerosis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal distal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11530",
    "question": "What phenotype is associated with Kabuki syndrome 1?",
    "seeds": [
      "Kabuki syndrome 1"
    ],
    "gold_answer": "Clinodactyly of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11531",
    "question": "What is associated with Piezogenic pedal papules?",
    "seeds": [
      "Piezogenic pedal papules"
    ],
    "gold_answer": "Papule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11532",
    "question": "What is associated with Oculopharyngodistal myopathy 4?",
    "seeds": [
      "Oculopharyngodistal myopathy 4"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11533",
    "question": "What is associated with Neurodevelopmental disorder with hypotonia, poor growth, dysmorphic facies, and agammaglobulinemia?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia, poor growth, dysmorphic facies, and agammaglobulinemia"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11534",
    "question": "What is associated with Short telomere length?",
    "seeds": [
      "Short telomere length"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11535",
    "question": "What is associated with Li-Fraumeni syndrome?",
    "seeds": [
      "Li-Fraumeni syndrome"
    ],
    "gold_answer": "Male reproductive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11536",
    "question": "What phenotype is associated with Spastic paraplegia 12, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 12, autosomal dominant"
    ],
    "gold_answer": "Impaired vibration sensation in the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11537",
    "question": "What is associated with Epidermolysis bullosa, junctional 5A, intermediate?",
    "seeds": [
      "Epidermolysis bullosa, junctional 5A, intermediate"
    ],
    "gold_answer": "Absent hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11538",
    "question": "What is associated with Anisocoria?",
    "seeds": [
      "Anisocoria"
    ],
    "gold_answer": "Abnormal pupil morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11539",
    "question": "What is associated with Follicular thyroid carcinoma?",
    "seeds": [
      "Follicular thyroid carcinoma"
    ],
    "gold_answer": "Neoplasm of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11540",
    "question": "What is associated with Sclerosis of the distal phalanx of the hallux?",
    "seeds": [
      "Sclerosis of the distal phalanx of the hallux"
    ],
    "gold_answer": "Sclerosis of toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11541",
    "question": "What is associated with Spermatogenic failure, X-linked, 8, susceptibility to?",
    "seeds": [
      "Spermatogenic failure, X-linked, 8, susceptibility to"
    ],
    "gold_answer": "Abnormal sperm tail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11542",
    "question": "What is associated with Vertebral artery hypoplasia?",
    "seeds": [
      "Vertebral artery hypoplasia"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11543",
    "question": "What phenotype is associated with Microphthalmia, isolated, with coloboma 6?",
    "seeds": [
      "Microphthalmia, isolated, with coloboma 6"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11544",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 34?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 34"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11545",
    "question": "What is associated with Fractured middle phalanx of pedal digit 3?",
    "seeds": [
      "Fractured middle phalanx of pedal digit 3"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11546",
    "question": "What is associated with X-linked intellectual disability, Shrimpton type?",
    "seeds": [
      "X-linked intellectual disability, Shrimpton type"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11547",
    "question": "What is associated with Anti-U11/U12 RNP antibody positivity?",
    "seeds": [
      "Anti-U11/U12 RNP antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11548",
    "question": "What is associated with Renal tubular karyomegaly?",
    "seeds": [
      "Renal tubular karyomegaly"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11549",
    "question": "What is associated with Abnormal fibula morphology?",
    "seeds": [
      "Abnormal fibula morphology"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11550",
    "question": "What is associated with Chronic fatigue?",
    "seeds": [
      "Chronic fatigue"
    ],
    "gold_answer": "Fatigue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11551",
    "question": "What is associated with Ovarian mass?",
    "seeds": [
      "Ovarian mass"
    ],
    "gold_answer": "Abnormality of the ovary",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11552",
    "question": "What is associated with Neurodevelopmental abnormality?",
    "seeds": [
      "Neurodevelopmental abnormality"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11553",
    "question": "What is associated with Stippling of the epiphyses of the 3rd finger?",
    "seeds": [
      "Stippling of the epiphyses of the 3rd finger"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11554",
    "question": "What is associated with Iris cyst?",
    "seeds": [
      "Iris cyst"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11555",
    "question": "What is associated with Elevated circulating creatine kinase concentration?",
    "seeds": [
      "Elevated circulating creatine kinase concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11556",
    "question": "What is associated with Short 4th toe?",
    "seeds": [
      "Short 4th toe"
    ],
    "gold_answer": "Short toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11557",
    "question": "What is associated with Osteosclerosis of ribs?",
    "seeds": [
      "Osteosclerosis of ribs"
    ],
    "gold_answer": "Abnormal enchondral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11558",
    "question": "What is associated with Tibiofibular diastasis?",
    "seeds": [
      "Tibiofibular diastasis"
    ],
    "gold_answer": "Abnormal tibia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11559",
    "question": "What is associated with Anti-Japanese encephalitis virus-specific antibody positivity?",
    "seeds": [
      "Anti-Japanese encephalitis virus-specific antibody positivity"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11560",
    "question": "What phenotype is associated with Combined oxidative phosphorylation deficiency 60?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 60"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11561",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 92?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 92"
    ],
    "gold_answer": "Blepharophimosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11562",
    "question": "What phenotype is associated with Nephrotic syndrome, type 26?",
    "seeds": [
      "Nephrotic syndrome, type 26"
    ],
    "gold_answer": "Steroid-resistant nephrotic syndrome",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11563",
    "question": "What is associated with Pyknoachondrogenesis?",
    "seeds": [
      "Pyknoachondrogenesis"
    ],
    "gold_answer": "Abnormal nasal dorsum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11564",
    "question": "What phenotype is associated with Tyrosinemia type 2?",
    "seeds": [
      "Tyrosinemia type 2"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11565",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 104?",
    "seeds": [
      "Developmental and epileptic encephalopathy 104"
    ],
    "gold_answer": "Bilateral tonic-clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11566",
    "question": "What is associated with Spastic paraplegia 64, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 64, autosomal recessive"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11567",
    "question": "What is associated with Adrenal xanthomatosis?",
    "seeds": [
      "Adrenal xanthomatosis"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11568",
    "question": "What is associated with Spondyloepiphyseal dysplasia?",
    "seeds": [
      "Spondyloepiphyseal dysplasia"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11569",
    "question": "What is associated with EEG with irregular generalized spike and wave complexes?",
    "seeds": [
      "EEG with irregular generalized spike and wave complexes"
    ],
    "gold_answer": "EEG with generalized epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11570",
    "question": "What is associated with Increased neutrophil ribosomes?",
    "seeds": [
      "Increased neutrophil ribosomes"
    ],
    "gold_answer": "Abnormality of neutrophils",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11571",
    "question": "What is associated with Usher syndrome type 1?",
    "seeds": [
      "Usher syndrome type 1"
    ],
    "gold_answer": "Retinal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11572",
    "question": "What is associated with Bowed humerus?",
    "seeds": [
      "Bowed humerus"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11573",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 96?",
    "seeds": [
      "Developmental and epileptic encephalopathy 96"
    ],
    "gold_answer": "Epileptic encephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11574",
    "question": "What is associated with Hypoplasia of the ovary?",
    "seeds": [
      "Hypoplasia of the ovary"
    ],
    "gold_answer": "Abnormality of the ovary",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11575",
    "question": "What phenotype is associated with Short-Rib thoracic dysplasia 14 with polydactyly?",
    "seeds": [
      "Short-Rib thoracic dysplasia 14 with polydactyly"
    ],
    "gold_answer": "Aplasia of the olfactory bulb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11576",
    "question": "What phenotype is associated with Brachyolmia, Maroteaux type?",
    "seeds": [
      "Brachyolmia, Maroteaux type"
    ],
    "gold_answer": "Wide intermamillary distance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11577",
    "question": "What is associated with Polyarticular arthritis?",
    "seeds": [
      "Polyarticular arthritis"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11578",
    "question": "What is associated with Diverticulosis of trachea?",
    "seeds": [
      "Diverticulosis of trachea"
    ],
    "gold_answer": "Abnormal tracheobronchial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11579",
    "question": "What is associated with Atlantoaxial dislocation?",
    "seeds": [
      "Atlantoaxial dislocation"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11580",
    "question": "What is associated with Increased circulating inosine concentration?",
    "seeds": [
      "Increased circulating inosine concentration"
    ],
    "gold_answer": "Abnormal circulating purine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11581",
    "question": "What is associated with Positive urine infectious agent test?",
    "seeds": [
      "Positive urine infectious agent test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11582",
    "question": "What is associated with Insulin receptor antibody positivity?",
    "seeds": [
      "Insulin receptor antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11583",
    "question": "What is associated with Short middle phalanx of the 5th finger?",
    "seeds": [
      "Short middle phalanx of the 5th finger"
    ],
    "gold_answer": "Short middle phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11584",
    "question": "What is associated with Increased sputum production?",
    "seeds": [
      "Increased sputum production"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11585",
    "question": "What is associated with KLHL7-related Crisponi/cold-induced sweating-like syndrome?",
    "seeds": [
      "KLHL7-related Crisponi/cold-induced sweating-like syndrome"
    ],
    "gold_answer": "KLHL7",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_11586",
    "question": "What is associated with Paranoia?",
    "seeds": [
      "Paranoia"
    ],
    "gold_answer": "Cognitive distortion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11587",
    "question": "What is associated with Mucopolysaccharidosis, type II?",
    "seeds": [
      "Mucopolysaccharidosis, type II"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11588",
    "question": "What phenotype is associated with Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency?",
    "seeds": [
      "Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency"
    ],
    "gold_answer": "Type I diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11589",
    "question": "What is associated with Facial paresis, hereditary congenital, 2?",
    "seeds": [
      "Facial paresis, hereditary congenital, 2"
    ],
    "gold_answer": "Abnormality of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11590",
    "question": "What is associated with Collier's sign?",
    "seeds": [
      "Collier's sign"
    ],
    "gold_answer": "Eyelid retraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11591",
    "question": "What is associated with Anti-TRIM46 antibody?",
    "seeds": [
      "Anti-TRIM46 antibody"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11592",
    "question": "What is associated with Lipodystrophy, familial partial, type 3?",
    "seeds": [
      "Lipodystrophy, familial partial, type 3"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11593",
    "question": "What is associated with Mosaic monosomy X syndrome?",
    "seeds": [
      "Mosaic monosomy X syndrome"
    ],
    "gold_answer": "Abnormal diminished volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11594",
    "question": "What is associated with Anhidrotic ectodermal dysplasia?",
    "seeds": [
      "Anhidrotic ectodermal dysplasia"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11595",
    "question": "What is associated with Focal aware cognitive seizure with receptive dysphasia/aphasia?",
    "seeds": [
      "Focal aware cognitive seizure with receptive dysphasia/aphasia"
    ],
    "gold_answer": "Focal cognitive seizure with receptive dysphasia/aphasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11596",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 44?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 44"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11597",
    "question": "What is associated with 9q21.13 microdeletion syndrome?",
    "seeds": [
      "9q21.13 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11598",
    "question": "What is associated with Pigmented nodular adrenocortical disease, primary, 2?",
    "seeds": [
      "Pigmented nodular adrenocortical disease, primary, 2"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11599",
    "question": "What is associated with SIX2-related frontonasal dysplasia?",
    "seeds": [
      "SIX2-related frontonasal dysplasia"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11600",
    "question": "What is associated with Koebner Phenomenon?",
    "seeds": [
      "Koebner Phenomenon"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11601",
    "question": "What is associated with Hypoplastic anterior commissure?",
    "seeds": [
      "Hypoplastic anterior commissure"
    ],
    "gold_answer": "Abnormality of the anterior commissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11602",
    "question": "What is associated with Cartilage-hair hypoplasia?",
    "seeds": [
      "Cartilage-hair hypoplasia"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11603",
    "question": "What is associated with Focal-onset seizure evolving into bilateral convulsive status epilepticus?",
    "seeds": [
      "Focal-onset seizure evolving into bilateral convulsive status epilepticus"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11604",
    "question": "What phenotype is associated with Thyroid hormone metabolism, abnormal, 3?",
    "seeds": [
      "Thyroid hormone metabolism, abnormal, 3"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11605",
    "question": "What is associated with Osteolytic defect of thumb phalanx?",
    "seeds": [
      "Osteolytic defect of thumb phalanx"
    ],
    "gold_answer": "Abnormality of thumb phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11606",
    "question": "What is associated with Iliac arterial calcification?",
    "seeds": [
      "Iliac arterial calcification"
    ],
    "gold_answer": "Arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11607",
    "question": "What is associated with Small epiphyses of the 5th toe?",
    "seeds": [
      "Small epiphyses of the 5th toe"
    ],
    "gold_answer": "Small epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11608",
    "question": "What is associated with Alopecia, neurologic defects, and endocrinopathy syndrome?",
    "seeds": [
      "Alopecia, neurologic defects, and endocrinopathy syndrome"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11609",
    "question": "What is associated with Aspirin-induced asthma?",
    "seeds": [
      "Aspirin-induced asthma"
    ],
    "gold_answer": "Immunologic hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11610",
    "question": "What is associated with Microcephaly, short stature, and impaired glucose metabolism 2?",
    "seeds": [
      "Microcephaly, short stature, and impaired glucose metabolism 2"
    ],
    "gold_answer": "Hypoglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11611",
    "question": "What phenotype is associated with Thiel-Behnke corneal dystrophy?",
    "seeds": [
      "Thiel-Behnke corneal dystrophy"
    ],
    "gold_answer": "Astigmatism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11612",
    "question": "What is associated with Ectopic ovary?",
    "seeds": [
      "Ectopic ovary"
    ],
    "gold_answer": "Abnormality of the ovary",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11613",
    "question": "What is associated with Variant ABeta2M amyloidosis?",
    "seeds": [
      "Variant ABeta2M amyloidosis"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11614",
    "question": "What is associated with Jaw hyporeflexia?",
    "seeds": [
      "Jaw hyporeflexia"
    ],
    "gold_answer": "Abnormality of jaw muscles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11615",
    "question": "What is associated with Venom allergy?",
    "seeds": [
      "Venom allergy"
    ],
    "gold_answer": "Immunologic hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11616",
    "question": "What is associated with Increased circulating interleukin 23 concentration?",
    "seeds": [
      "Increased circulating interleukin 23 concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11617",
    "question": "What phenotype is associated with Congenital primary aphakia?",
    "seeds": [
      "Congenital primary aphakia"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11618",
    "question": "What is associated with Hyaline fibromatosis syndrome?",
    "seeds": [
      "Hyaline fibromatosis syndrome"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11619",
    "question": "What is associated with Thrombocytosis?",
    "seeds": [
      "Thrombocytosis"
    ],
    "gold_answer": "Abnormality of thrombocytes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11620",
    "question": "What is associated with Focal impaired awareness cognitive seizure with deja vu/jamais vu?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with deja vu/jamais vu"
    ],
    "gold_answer": "Focal cognitive seizure with deja vu/jamais vu",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11621",
    "question": "What is associated with Leber congenital amaurosis, type I?",
    "seeds": [
      "Leber congenital amaurosis, type I"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11622",
    "question": "What is associated with Precocious puberty in males?",
    "seeds": [
      "Precocious puberty in males"
    ],
    "gold_answer": "Early onset of sexual maturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11623",
    "question": "What is associated with Headache?",
    "seeds": [
      "Headache"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11624",
    "question": "What is associated with Lichtenstein-Knorr syndrome?",
    "seeds": [
      "Lichtenstein-Knorr syndrome"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11625",
    "question": "What is associated with Congenital onset?",
    "seeds": [
      "Congenital onset"
    ],
    "gold_answer": "Clinical course",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11626",
    "question": "What is associated with Chin with vertical crease?",
    "seeds": [
      "Chin with vertical crease"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11627",
    "question": "What is associated with Congenital hydrocephalus?",
    "seeds": [
      "Congenital hydrocephalus"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11628",
    "question": "What is associated with Fetal nuchal edema?",
    "seeds": [
      "Fetal nuchal edema"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11629",
    "question": "What is associated with Abnormal gonadotropin-releasing hormone concentration?",
    "seeds": [
      "Abnormal gonadotropin-releasing hormone concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11630",
    "question": "What is associated with Enlarged flash visual evoked potentials?",
    "seeds": [
      "Enlarged flash visual evoked potentials"
    ],
    "gold_answer": "Abnormality of visual evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11631",
    "question": "What is associated with Slowed horizontal saccades?",
    "seeds": [
      "Slowed horizontal saccades"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11632",
    "question": "What is associated with Autosomal dominant Charcot-Marie-Tooth disease type 2B?",
    "seeds": [
      "Autosomal dominant Charcot-Marie-Tooth disease type 2B"
    ],
    "gold_answer": "RAB7A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_11633",
    "question": "What is associated with Pancreatic agenesis and congenital heart defects?",
    "seeds": [
      "Pancreatic agenesis and congenital heart defects"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11634",
    "question": "What is associated with Positive bloodstream Borrelia miyamotoi nucleic acid test?",
    "seeds": [
      "Positive bloodstream Borrelia miyamotoi nucleic acid test"
    ],
    "gold_answer": "Positive bloodstream nucleic acid pathogen test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11635",
    "question": "What is associated with Hyperostosis?",
    "seeds": [
      "Hyperostosis"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11636",
    "question": "What is associated with Cystic pattern on pulmonary HRCT?",
    "seeds": [
      "Cystic pattern on pulmonary HRCT"
    ],
    "gold_answer": "Pulmonary interstitial high-resolution computed tomography abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11637",
    "question": "What phenotype is associated with Aneurysm, intracranial berry, 1?",
    "seeds": [
      "Aneurysm, intracranial berry, 1"
    ],
    "gold_answer": "Intracranial hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11638",
    "question": "What is associated with Congenital plasminogen activator inhibitor type 1 deficiency?",
    "seeds": [
      "Congenital plasminogen activator inhibitor type 1 deficiency"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11639",
    "question": "What is associated with Hypoglycemia of infancy, leucine-sensitive?",
    "seeds": [
      "Hypoglycemia of infancy, leucine-sensitive"
    ],
    "gold_answer": "Reduced consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11640",
    "question": "What is associated with Toe syndactyly?",
    "seeds": [
      "Toe syndactyly"
    ],
    "gold_answer": "Syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11641",
    "question": "What phenotype is associated with Hawkinsinuria?",
    "seeds": [
      "Hawkinsinuria"
    ],
    "gold_answer": "Abnormality of tyrosine metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11642",
    "question": "What is associated with Partial hyposmia?",
    "seeds": [
      "Partial hyposmia"
    ],
    "gold_answer": "Abnormality of the sense of smell",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11643",
    "question": "What is associated with Chess-pawn distal phalanges?",
    "seeds": [
      "Chess-pawn distal phalanges"
    ],
    "gold_answer": "Abnormal distal phalanx morphology of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11644",
    "question": "What is associated with Fixated interest with abnormal intensity?",
    "seeds": [
      "Fixated interest with abnormal intensity"
    ],
    "gold_answer": "Restricted or repetitive behaviors or interests",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11645",
    "question": "What is associated with Glaucoma - sleep apnea?",
    "seeds": [
      "Glaucoma - sleep apnea"
    ],
    "gold_answer": "Sleep-related breathing disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11646",
    "question": "What is associated with Absent ossification of the trapezium?",
    "seeds": [
      "Absent ossification of the trapezium"
    ],
    "gold_answer": "Abnormal trapezium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11647",
    "question": "What is associated with Thickened elastic fibers in the dermis?",
    "seeds": [
      "Thickened elastic fibers in the dermis"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11648",
    "question": "What is associated with Dwarfism with tall vertebrae?",
    "seeds": [
      "Dwarfism with tall vertebrae"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11649",
    "question": "What is associated with Abnormal vestibulo-ocular reflex?",
    "seeds": [
      "Abnormal vestibulo-ocular reflex"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11650",
    "question": "What is associated with Status post organ transplantation?",
    "seeds": [
      "Status post organ transplantation"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11651",
    "question": "What is associated with Protein avoidance?",
    "seeds": [
      "Protein avoidance"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11652",
    "question": "What is associated with Dimple chin?",
    "seeds": [
      "Dimple chin"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11653",
    "question": "What is associated with Breast mass?",
    "seeds": [
      "Breast mass"
    ],
    "gold_answer": "Abnormal breast morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11654",
    "question": "What is associated with Chronic metabolic acidosis?",
    "seeds": [
      "Chronic metabolic acidosis"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11655",
    "question": "What is associated with Decreased circulating free T4 concentration?",
    "seeds": [
      "Decreased circulating free T4 concentration"
    ],
    "gold_answer": "Abnormal circulating free T4 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11656",
    "question": "What is associated with Abnormal fifth toe morphology?",
    "seeds": [
      "Abnormal fifth toe morphology"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11657",
    "question": "What is associated with Gastric hypertrophy?",
    "seeds": [
      "Gastric hypertrophy"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11658",
    "question": "What is associated with Elevated circulating alpha-oxoadipic acid concentration?",
    "seeds": [
      "Elevated circulating alpha-oxoadipic acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11659",
    "question": "What is associated with Hyperpolarized transepithelial nasal potential difference?",
    "seeds": [
      "Hyperpolarized transepithelial nasal potential difference"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11660",
    "question": "What is associated with Facial erythema?",
    "seeds": [
      "Facial erythema"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11661",
    "question": "What phenotype is associated with Nephrotic syndrome, type 13?",
    "seeds": [
      "Nephrotic syndrome, type 13"
    ],
    "gold_answer": "Stage 5 chronic kidney disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11662",
    "question": "What is associated with Increased size of nasopharyngeal adenoids?",
    "seeds": [
      "Increased size of nasopharyngeal adenoids"
    ],
    "gold_answer": "Abnormal size of nasopharyngeal adenoids",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11663",
    "question": "What is associated with Trichothiodystrophy 6, nonphotosensitive?",
    "seeds": [
      "Trichothiodystrophy 6, nonphotosensitive"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11664",
    "question": "What is associated with Optic disc drusen?",
    "seeds": [
      "Optic disc drusen"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11665",
    "question": "What phenotype is associated with Colobomatous microphthalmia-obesity-hypogenitalism-intellectual disability syndrome?",
    "seeds": [
      "Colobomatous microphthalmia-obesity-hypogenitalism-intellectual disability syndrome"
    ],
    "gold_answer": "Nausea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11666",
    "question": "What is associated with Hereditary fibrosing poikiloderma-tendon contractures-myopathy-pulmonary fibrosis syndrome?",
    "seeds": [
      "Hereditary fibrosing poikiloderma-tendon contractures-myopathy-pulmonary fibrosis syndrome"
    ],
    "gold_answer": "FAM111B",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_11667",
    "question": "What is associated with HSPB8-related autosomal dominant distal axonal motor neuropathy-myofibrillar myopathy syndrome?",
    "seeds": [
      "HSPB8-related autosomal dominant distal axonal motor neuropathy-myofibrillar myopathy syndrome"
    ],
    "gold_answer": "HSPB8",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_11668",
    "question": "What is associated with Male sexual dysfunction?",
    "seeds": [
      "Male sexual dysfunction"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11669",
    "question": "What is associated with Indurated nodule?",
    "seeds": [
      "Indurated nodule"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11670",
    "question": "What is associated with Supraauricular pit?",
    "seeds": [
      "Supraauricular pit"
    ],
    "gold_answer": "Periauricular skin pits",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11671",
    "question": "What is associated with Hypomagnesiuria?",
    "seeds": [
      "Hypomagnesiuria"
    ],
    "gold_answer": "Abnormal urine magnesium concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11672",
    "question": "What is associated with Ectodermal dysplasia 11B, hypohidrotic/hair/tooth type, autosomal recessive?",
    "seeds": [
      "Ectodermal dysplasia 11B, hypohidrotic/hair/tooth type, autosomal recessive"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11673",
    "question": "What is associated with Bacterial encephalitis?",
    "seeds": [
      "Bacterial encephalitis"
    ],
    "gold_answer": "Unusual CNS infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11674",
    "question": "What is associated with Lipodystrophy, familial partial, type 4?",
    "seeds": [
      "Lipodystrophy, familial partial, type 4"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11675",
    "question": "What is associated with Focal motor seizure?",
    "seeds": [
      "Focal motor seizure"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11676",
    "question": "What phenotype is associated with Premature ovarian failure 14?",
    "seeds": [
      "Premature ovarian failure 14"
    ],
    "gold_answer": "Primary amenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11677",
    "question": "What phenotype is associated with Maturity-onset diabetes of the young, type III?",
    "seeds": [
      "Maturity-onset diabetes of the young, type III"
    ],
    "gold_answer": "Type II diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11678",
    "question": "What is associated with Speech development, delayed, with facial asymmetry, strabismus, andtransverse earlobe crease?",
    "seeds": [
      "Speech development, delayed, with facial asymmetry, strabismus, andtransverse earlobe crease"
    ],
    "gold_answer": "Abnormal location of ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11679",
    "question": "What phenotype is associated with Severe combined immunodeficiency due to complete RAG1/2 deficiency?",
    "seeds": [
      "Severe combined immunodeficiency due to complete RAG1/2 deficiency"
    ],
    "gold_answer": "Lymphadenitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11680",
    "question": "What is associated with Peroxisome biogenesis disorder 5B?",
    "seeds": [
      "Peroxisome biogenesis disorder 5B"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11681",
    "question": "What is associated with Talipes varus?",
    "seeds": [
      "Talipes varus"
    ],
    "gold_answer": "Abnormality of the ankle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11682",
    "question": "What phenotype is associated with Palmoplantar keratoderma-esophageal carcinoma syndrome?",
    "seeds": [
      "Palmoplantar keratoderma-esophageal carcinoma syndrome"
    ],
    "gold_answer": "Abnormal esophagus physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11683",
    "question": "What is associated with Congenital hypothyroidism?",
    "seeds": [
      "Congenital hypothyroidism"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11684",
    "question": "What is associated with Hyperlipoproteinemia?",
    "seeds": [
      "Hyperlipoproteinemia"
    ],
    "gold_answer": "Abnormality of lipoprotein cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11685",
    "question": "What is associated with 3-methylglutaconic aciduria type 9?",
    "seeds": [
      "3-methylglutaconic aciduria type 9"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11686",
    "question": "What phenotype is associated with Spondylo-ocular syndrome?",
    "seeds": [
      "Spondylo-ocular syndrome"
    ],
    "gold_answer": "Myopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11687",
    "question": "What is associated with Macular hole?",
    "seeds": [
      "Macular hole"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11688",
    "question": "What is associated with Microphthalmia/coloboma 13?",
    "seeds": [
      "Microphthalmia/coloboma 13"
    ],
    "gold_answer": "Abnormality of corneal size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11689",
    "question": "What is associated with Short-rib thoracic dysplasia 21 without polydactyly?",
    "seeds": [
      "Short-rib thoracic dysplasia 21 without polydactyly"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11690",
    "question": "What is associated with Anterior cervical hypertrichosis?",
    "seeds": [
      "Anterior cervical hypertrichosis"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11691",
    "question": "What is associated with Small epiphyses?",
    "seeds": [
      "Small epiphyses"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11692",
    "question": "What phenotype is associated with Non-distal duplication 13q syndrome?",
    "seeds": [
      "Non-distal duplication 13q syndrome"
    ],
    "gold_answer": "Thin vermilion border",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11693",
    "question": "What is associated with Duplication of the distal phalanx of the 5th finger?",
    "seeds": [
      "Duplication of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11694",
    "question": "What is associated with Peeling skin syndrome 3?",
    "seeds": [
      "Peeling skin syndrome 3"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11695",
    "question": "What is associated with Fractured metatarsal bone of digit 1?",
    "seeds": [
      "Fractured metatarsal bone of digit 1"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11696",
    "question": "What is associated with Inferior cerebellar vermis hypoplasia?",
    "seeds": [
      "Inferior cerebellar vermis hypoplasia"
    ],
    "gold_answer": "Cerebellar hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11697",
    "question": "What is associated with Brachytelephalangic chondrodysplasia punctata?",
    "seeds": [
      "Brachytelephalangic chondrodysplasia punctata"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11698",
    "question": "What is associated with Abnormality of the vitamin B3 metabolism?",
    "seeds": [
      "Abnormality of the vitamin B3 metabolism"
    ],
    "gold_answer": "Abnormality of vitamin B metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11699",
    "question": "What is associated with Low phospholipid-associated cholelithiasis?",
    "seeds": [
      "Low phospholipid-associated cholelithiasis"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11700",
    "question": "What is associated with Proximal symphalangism?",
    "seeds": [
      "Proximal symphalangism"
    ],
    "gold_answer": "Abnormal elbow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11701",
    "question": "What is associated with Abnormal conjugate eye movement?",
    "seeds": [
      "Abnormal conjugate eye movement"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11702",
    "question": "What is associated with Decreased CSF amyloid concentration?",
    "seeds": [
      "Decreased CSF amyloid concentration"
    ],
    "gold_answer": "Abnormal CSF amyloid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11703",
    "question": "What is associated with Abnormal number of tubercles?",
    "seeds": [
      "Abnormal number of tubercles"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11704",
    "question": "What is associated with Positive bloodstream adenovirus nucleic acid test?",
    "seeds": [
      "Positive bloodstream adenovirus nucleic acid test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11705",
    "question": "What is associated with Reduced ratio of renal calcium clearance to creatinine clearance?",
    "seeds": [
      "Reduced ratio of renal calcium clearance to creatinine clearance"
    ],
    "gold_answer": "Abnormality of urine calcium concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11706",
    "question": "What is associated with Charcot-Marie-Tooth disease type 2B2?",
    "seeds": [
      "Charcot-Marie-Tooth disease type 2B2"
    ],
    "gold_answer": "PNKP",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_11707",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 5?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 5"
    ],
    "gold_answer": "Myoglobinuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11708",
    "question": "What is associated with Abnormal naive T cell proportion?",
    "seeds": [
      "Abnormal naive T cell proportion"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11709",
    "question": "What is associated with Small epiphyses of the 2nd finger?",
    "seeds": [
      "Small epiphyses of the 2nd finger"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11710",
    "question": "What is associated with Rahman syndrome?",
    "seeds": [
      "Rahman syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11711",
    "question": "What is associated with Verrucous cell carcinoma of the tongue?",
    "seeds": [
      "Verrucous cell carcinoma of the tongue"
    ],
    "gold_answer": "Abnormality of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11712",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 20?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 20"
    ],
    "gold_answer": "EEG with generalized epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11713",
    "question": "What is associated with Osteogenesis imperfecta type 5?",
    "seeds": [
      "Osteogenesis imperfecta type 5"
    ],
    "gold_answer": "IFITM5",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_11714",
    "question": "What is associated with Alzheimer disease 9, susceptibility to?",
    "seeds": [
      "Alzheimer disease 9, susceptibility to"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11715",
    "question": "What is associated with Penile thrush?",
    "seeds": [
      "Penile thrush"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11716",
    "question": "What is associated with Increased hepatic glycogen content?",
    "seeds": [
      "Increased hepatic glycogen content"
    ],
    "gold_answer": "Abnormal hepatic glycogen storage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11717",
    "question": "What is associated with Bleeding disorder, vascular-type?",
    "seeds": [
      "Bleeding disorder, vascular-type"
    ],
    "gold_answer": "Abnormal female reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11718",
    "question": "What is associated with Abnormal oral mucosa morphology?",
    "seeds": [
      "Abnormal oral mucosa morphology"
    ],
    "gold_answer": "Abnormality of the mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11719",
    "question": "What is associated with Elevated CSF DOPA concentration?",
    "seeds": [
      "Elevated CSF DOPA concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11720",
    "question": "What is associated with Muscle fiber actin filament accumulation?",
    "seeds": [
      "Muscle fiber actin filament accumulation"
    ],
    "gold_answer": "Pathological inclusion body",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11721",
    "question": "What is associated with Elevated circulating E selectin level?",
    "seeds": [
      "Elevated circulating E selectin level"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11722",
    "question": "What is associated with Partial duplication of the phalanges of the 5th finger?",
    "seeds": [
      "Partial duplication of the phalanges of the 5th finger"
    ],
    "gold_answer": "Partial duplication of the phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11723",
    "question": "What is associated with POMT2-related limb-girdle muscular dystrophy R14?",
    "seeds": [
      "POMT2-related limb-girdle muscular dystrophy R14"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11724",
    "question": "What is associated with Aortic medial fibrosis?",
    "seeds": [
      "Aortic medial fibrosis"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11725",
    "question": "What phenotype is associated with Seizures, benign familial neonatal, 1?",
    "seeds": [
      "Seizures, benign familial neonatal, 1"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11726",
    "question": "What phenotype is associated with D-lactic aciduria with susceptibility to gout?",
    "seeds": [
      "D-lactic aciduria with susceptibility to gout"
    ],
    "gold_answer": "Aniridia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11727",
    "question": "What is associated with Retinal degeneration-nanophthalmos-glaucoma syndrome?",
    "seeds": [
      "Retinal degeneration-nanophthalmos-glaucoma syndrome"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11728",
    "question": "What phenotype is associated with Night blindness, congenital stationary, autosomal dominant 3?",
    "seeds": [
      "Night blindness, congenital stationary, autosomal dominant 3"
    ],
    "gold_answer": "Early-onset non-progressive night blindness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11729",
    "question": "What is associated with Abnormality of the epiphyses of the 4th finger?",
    "seeds": [
      "Abnormality of the epiphyses of the 4th finger"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11730",
    "question": "What is associated with Prader-Willi syndrome due to paternal 15q11q13 deletion?",
    "seeds": [
      "Prader-Willi syndrome due to paternal 15q11q13 deletion"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11731",
    "question": "What is associated with Posterior scalloping of vertebral bodies?",
    "seeds": [
      "Posterior scalloping of vertebral bodies"
    ],
    "gold_answer": "Biconcave vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11732",
    "question": "What is associated with Partial absence of finger?",
    "seeds": [
      "Partial absence of finger"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11733",
    "question": "What is associated with Slender nose?",
    "seeds": [
      "Slender nose"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11734",
    "question": "What is associated with Testicular teratoma?",
    "seeds": [
      "Testicular teratoma"
    ],
    "gold_answer": "Genital neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11735",
    "question": "What is associated with Elevated urine propionic acid level?",
    "seeds": [
      "Elevated urine propionic acid level"
    ],
    "gold_answer": "Organic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11736",
    "question": "What is associated with Distal radial epiphyseal osteolysis?",
    "seeds": [
      "Distal radial epiphyseal osteolysis"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11737",
    "question": "What is associated with Segmental fracture?",
    "seeds": [
      "Segmental fracture"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11738",
    "question": "What is associated with Auditory sensitivity?",
    "seeds": [
      "Auditory sensitivity"
    ],
    "gold_answer": "Sensory behavioral abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11739",
    "question": "What is associated with Gallop rhythm?",
    "seeds": [
      "Gallop rhythm"
    ],
    "gold_answer": "Abnormal heart sound",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11740",
    "question": "What is associated with Hirschsprung disease, susceptibility to, 5?",
    "seeds": [
      "Hirschsprung disease, susceptibility to, 5"
    ],
    "gold_answer": "Abnormal large intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11741",
    "question": "What is associated with Megalencephalic leukoencephalopathy with subcortical cysts 1?",
    "seeds": [
      "Megalencephalic leukoencephalopathy with subcortical cysts 1"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11742",
    "question": "What is associated with Anti-GM4 antibody positivity?",
    "seeds": [
      "Anti-GM4 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11743",
    "question": "What is associated with Conjunctival follicles?",
    "seeds": [
      "Conjunctival follicles"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11744",
    "question": "What is associated with Cortical radial artery foam cell hypercellularity?",
    "seeds": [
      "Cortical radial artery foam cell hypercellularity"
    ],
    "gold_answer": "Cortical radial artery leukocyte hypercellularity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11745",
    "question": "What phenotype is associated with Encephalopathy, familial, with neuroserpin inclusion bodies?",
    "seeds": [
      "Encephalopathy, familial, with neuroserpin inclusion bodies"
    ],
    "gold_answer": "Distal sensory impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11746",
    "question": "What is associated with Vitamin K antagonist embryofetopathy?",
    "seeds": [
      "Vitamin K antagonist embryofetopathy"
    ],
    "gold_answer": "Open neural tube defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11747",
    "question": "What is associated with Decreased proportion of marginal zone B cells?",
    "seeds": [
      "Decreased proportion of marginal zone B cells"
    ],
    "gold_answer": "Abnormal memory B cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11748",
    "question": "What is associated with Abnormality of cervical plexus?",
    "seeds": [
      "Abnormality of cervical plexus"
    ],
    "gold_answer": "Abnormality of somatic nerve plexus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11749",
    "question": "What is associated with Amyloidosis, cutaneous bullous?",
    "seeds": [
      "Amyloidosis, cutaneous bullous"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11750",
    "question": "What is associated with Focal autonomic seizure?",
    "seeds": [
      "Focal autonomic seizure"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11751",
    "question": "What is associated with Angel-Shaped phalangoepiphyseal dysplasia?",
    "seeds": [
      "Angel-Shaped phalangoepiphyseal dysplasia"
    ],
    "gold_answer": "Osteoarthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11752",
    "question": "What is associated with Acrorenal-Mandibular syndrome?",
    "seeds": [
      "Acrorenal-Mandibular syndrome"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11753",
    "question": "What is associated with Cleft, median, of upper lip with polyps of facial skin and nasal mucosa?",
    "seeds": [
      "Cleft, median, of upper lip with polyps of facial skin and nasal mucosa"
    ],
    "gold_answer": "Abnormality of globe location",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11754",
    "question": "What is associated with Hyporeflexia?",
    "seeds": [
      "Hyporeflexia"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11755",
    "question": "What phenotype is associated with CAOP syndrome?",
    "seeds": [
      "CAOP syndrome"
    ],
    "gold_answer": "Myopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11756",
    "question": "What is associated with Typified by incomplete penetrance?",
    "seeds": [
      "Typified by incomplete penetrance"
    ],
    "gold_answer": "Inheritance qualifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11757",
    "question": "What is associated with Retinal gliosis?",
    "seeds": [
      "Retinal gliosis"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11758",
    "question": "What is associated with Widely spaced teeth?",
    "seeds": [
      "Widely spaced teeth"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11759",
    "question": "What is associated with Female external genitalia in individual with 46,XY karyotype?",
    "seeds": [
      "Female external genitalia in individual with 46,XY karyotype"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11760",
    "question": "What is associated with Impaired cortisol response to insulin stimulation test?",
    "seeds": [
      "Impaired cortisol response to insulin stimulation test"
    ],
    "gold_answer": "Abnormal response to insulin tolerance test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11761",
    "question": "What is associated with Spondylometaphyseal dysplasia, Kozlowski type?",
    "seeds": [
      "Spondylometaphyseal dysplasia, Kozlowski type"
    ],
    "gold_answer": "Skeletal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11762",
    "question": "What phenotype is associated with Loeys-Dietz syndrome 5?",
    "seeds": [
      "Loeys-Dietz syndrome 5"
    ],
    "gold_answer": "Long palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11763",
    "question": "What is associated with Dilatation of celiac artery?",
    "seeds": [
      "Dilatation of celiac artery"
    ],
    "gold_answer": "Dilatation of an abdominal artery",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11764",
    "question": "What is associated with Abnormal buccal mucosa cell morphology?",
    "seeds": [
      "Abnormal buccal mucosa cell morphology"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11765",
    "question": "What is associated with Centrally nucleated skeletal muscle fibers?",
    "seeds": [
      "Centrally nucleated skeletal muscle fibers"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11766",
    "question": "What is associated with Neuropathy, hereditary sensory, type ID?",
    "seeds": [
      "Neuropathy, hereditary sensory, type ID"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11767",
    "question": "What is associated with Ameliorated by ethanol ingestion?",
    "seeds": [
      "Ameliorated by ethanol ingestion"
    ],
    "gold_answer": "Ameliorated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11768",
    "question": "What is associated with Renal cortical microcysts?",
    "seeds": [
      "Renal cortical microcysts"
    ],
    "gold_answer": "Renal cortical cysts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11769",
    "question": "What is associated with Anti-alanyl-tRNA synthetase antibody positivity?",
    "seeds": [
      "Anti-alanyl-tRNA synthetase antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11770",
    "question": "What is associated with Bitemporal hollowing?",
    "seeds": [
      "Bitemporal hollowing"
    ],
    "gold_answer": "Abnormality of the periorbital region",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11771",
    "question": "What is associated with Abnormal endocrine morphology?",
    "seeds": [
      "Abnormal endocrine morphology"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11772",
    "question": "What is associated with Osteochondromyxoma?",
    "seeds": [
      "Osteochondromyxoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11773",
    "question": "What is associated with Mitochondrial complex III deficiency, nuclear type 6?",
    "seeds": [
      "Mitochondrial complex III deficiency, nuclear type 6"
    ],
    "gold_answer": "Decreased liver function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11774",
    "question": "What is associated with Muscular dystrophy, limb-girdle, type 2A?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, type 2A"
    ],
    "gold_answer": "Abnormal seventh cranial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11775",
    "question": "What is associated with Aplasia of the left hemidiaphragm?",
    "seeds": [
      "Aplasia of the left hemidiaphragm"
    ],
    "gold_answer": "Congenital diaphragmatic hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11776",
    "question": "What is associated with Congenital disorder of glycosylation with defective fucosylation 2?",
    "seeds": [
      "Congenital disorder of glycosylation with defective fucosylation 2"
    ],
    "gold_answer": "Aggravated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11777",
    "question": "What is associated with Premature epimetaphyseal fusion in tibia?",
    "seeds": [
      "Premature epimetaphyseal fusion in tibia"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11778",
    "question": "What is associated with Aland island eye disease?",
    "seeds": [
      "Aland island eye disease"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11779",
    "question": "What phenotype is associated with Muenke syndrome?",
    "seeds": [
      "Muenke syndrome"
    ],
    "gold_answer": "Radial deviation of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11780",
    "question": "What is associated with Decreased mixed venous oxygen saturation?",
    "seeds": [
      "Decreased mixed venous oxygen saturation"
    ],
    "gold_answer": "Abnormal blood oxygen level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11781",
    "question": "What is associated with Use of intrauterine device?",
    "seeds": [
      "Use of intrauterine device"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11782",
    "question": "What phenotype is associated with Symphalangism with multiple anomalies of hands and feet?",
    "seeds": [
      "Symphalangism with multiple anomalies of hands and feet"
    ],
    "gold_answer": "Abnormal dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11783",
    "question": "What is associated with Abnormal mitochondrial number?",
    "seeds": [
      "Abnormal mitochondrial number"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11784",
    "question": "What is associated with Bracket epiphysis of the distal phalanx of the thumb?",
    "seeds": [
      "Bracket epiphysis of the distal phalanx of the thumb"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11785",
    "question": "What phenotype is associated with Camptodactyly with muscular hypoplasia, skeletal dysplasia, and abnormalpalmar creases?",
    "seeds": [
      "Camptodactyly with muscular hypoplasia, skeletal dysplasia, and abnormalpalmar creases"
    ],
    "gold_answer": "Mitral valve prolapse",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11786",
    "question": "What is associated with Fractured cervical vertebra?",
    "seeds": [
      "Fractured cervical vertebra"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11787",
    "question": "What is associated with Hypoplasia of the radius?",
    "seeds": [
      "Hypoplasia of the radius"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11788",
    "question": "What is associated with Disseminated cryptosporidium infection?",
    "seeds": [
      "Disseminated cryptosporidium infection"
    ],
    "gold_answer": "Opportunistic infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11789",
    "question": "What is associated with Neurodevelopmental disorder with spastic diplegia and visual defects?",
    "seeds": [
      "Neurodevelopmental disorder with spastic diplegia and visual defects"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11790",
    "question": "What is associated with Hyperactivity?",
    "seeds": [
      "Hyperactivity"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11791",
    "question": "What is associated with Gamma-sarcoglycan-related limb-girdle muscular dystrophy R5?",
    "seeds": [
      "Gamma-sarcoglycan-related limb-girdle muscular dystrophy R5"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11792",
    "question": "What is associated with Facial synkinesis?",
    "seeds": [
      "Facial synkinesis"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11793",
    "question": "What is associated with Symmetric great toe depigmentation?",
    "seeds": [
      "Symmetric great toe depigmentation"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11794",
    "question": "What is associated with Loss of consciousness?",
    "seeds": [
      "Loss of consciousness"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11795",
    "question": "What is associated with Loss of facial adipose tissue?",
    "seeds": [
      "Loss of facial adipose tissue"
    ],
    "gold_answer": "Adipose tissue loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11796",
    "question": "What is associated with Craniosynostosis, Philadelphia type?",
    "seeds": [
      "Craniosynostosis, Philadelphia type"
    ],
    "gold_answer": "Abnormal cranial suture/fontanelle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11797",
    "question": "What is associated with Spastic ataxia 11, autosomal dominant?",
    "seeds": [
      "Spastic ataxia 11, autosomal dominant"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11798",
    "question": "What is associated with Small posterior fossa?",
    "seeds": [
      "Small posterior fossa"
    ],
    "gold_answer": "Abnormal posterior cranial fossa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11799",
    "question": "What is associated with Congenital lactic acidosis?",
    "seeds": [
      "Congenital lactic acidosis"
    ],
    "gold_answer": "Lactic acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11800",
    "question": "What is associated with Imperforate atrioventricular valve?",
    "seeds": [
      "Imperforate atrioventricular valve"
    ],
    "gold_answer": "Abnormal heart valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11801",
    "question": "What is associated with Pseudobulbar affect?",
    "seeds": [
      "Pseudobulbar affect"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11802",
    "question": "What is associated with Multiple prenatal fractures?",
    "seeds": [
      "Multiple prenatal fractures"
    ],
    "gold_answer": "Increased susceptibility to fractures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11803",
    "question": "What is associated with 19p13.12 microdeletion syndrome?",
    "seeds": [
      "19p13.12 microdeletion syndrome"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11804",
    "question": "What is associated with Septo-optic dysplasia spectrum?",
    "seeds": [
      "Septo-optic dysplasia spectrum"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11805",
    "question": "What is associated with Abnormal tympanic membrane morphology?",
    "seeds": [
      "Abnormal tympanic membrane morphology"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11806",
    "question": "What is associated with Cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies?",
    "seeds": [
      "Cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies"
    ],
    "gold_answer": "LTBP4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_train_11807",
    "question": "What phenotype is associated with Arima syndrome?",
    "seeds": [
      "Arima syndrome"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11808",
    "question": "What is associated with Anti-Iglon5 antibody?",
    "seeds": [
      "Anti-Iglon5 antibody"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11809",
    "question": "What is associated with Elevated circulating butyrylcarnitine concentration?",
    "seeds": [
      "Elevated circulating butyrylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating C4 acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11810",
    "question": "What is associated with Aplasia/Hypoplasia of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Aplasia/Hypoplasia of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11811",
    "question": "What is associated with Spermatogenic failure 13?",
    "seeds": [
      "Spermatogenic failure 13"
    ],
    "gold_answer": "Abnormal spermatogenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11812",
    "question": "What is associated with Accumulation of muscle fiber myotilin?",
    "seeds": [
      "Accumulation of muscle fiber myotilin"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11813",
    "question": "What is associated with Skeletal muscle hypertrophy?",
    "seeds": [
      "Skeletal muscle hypertrophy"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11814",
    "question": "What is associated with Amyloidosis, Finnish type?",
    "seeds": [
      "Amyloidosis, Finnish type"
    ],
    "gold_answer": "Hypotension",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11815",
    "question": "What is associated with Pigment incontinence?",
    "seeds": [
      "Pigment incontinence"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11816",
    "question": "What is associated with Abnormal cognitive process?",
    "seeds": [
      "Abnormal cognitive process"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11817",
    "question": "What is associated with Abnormal male internal genitalia morphology?",
    "seeds": [
      "Abnormal male internal genitalia morphology"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11818",
    "question": "What is associated with Oculocerebrofacial syndrome, Kaufman type?",
    "seeds": [
      "Oculocerebrofacial syndrome, Kaufman type"
    ],
    "gold_answer": "Increased size of the clitoris",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11819",
    "question": "What phenotype is associated with Spondyloepimetaphyseal dysplasia, Faden-Alkuraya type?",
    "seeds": [
      "Spondyloepimetaphyseal dysplasia, Faden-Alkuraya type"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11820",
    "question": "What is associated with Spinocerebellar tract degeneration?",
    "seeds": [
      "Spinocerebellar tract degeneration"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11821",
    "question": "What is associated with Spinal muscular atrophy, Jokela type?",
    "seeds": [
      "Spinal muscular atrophy, Jokela type"
    ],
    "gold_answer": "Muscle hypertrophy of the lower extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11822",
    "question": "What is associated with Methylmalonic aciduria, transient, due to transcobalamin receptor defect?",
    "seeds": [
      "Methylmalonic aciduria, transient, due to transcobalamin receptor defect"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11823",
    "question": "What is associated with Vulval varicose vein?",
    "seeds": [
      "Vulval varicose vein"
    ],
    "gold_answer": "Abnormal female external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11824",
    "question": "What is associated with Abnormal pancreas size?",
    "seeds": [
      "Abnormal pancreas size"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11825",
    "question": "What is associated with Speech apraxia?",
    "seeds": [
      "Speech apraxia"
    ],
    "gold_answer": "Apraxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11826",
    "question": "What is associated with Rubinstein-Taybi syndrome 1?",
    "seeds": [
      "Rubinstein-Taybi syndrome 1"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11827",
    "question": "What is associated with Decreased circulating gonadotropin concentration?",
    "seeds": [
      "Decreased circulating gonadotropin concentration"
    ],
    "gold_answer": "Abnormal circulating gonadotropin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11828",
    "question": "What is associated with Stankiewicz-Isidor syndrome?",
    "seeds": [
      "Stankiewicz-Isidor syndrome"
    ],
    "gold_answer": "Agenesis of permanent molar",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11829",
    "question": "What is associated with Multiple bilateral pneumothoraces?",
    "seeds": [
      "Multiple bilateral pneumothoraces"
    ],
    "gold_answer": "Pneumothorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11830",
    "question": "What is associated with Chronic bilirubin encephalopathy?",
    "seeds": [
      "Chronic bilirubin encephalopathy"
    ],
    "gold_answer": "Dermatological manifestations of systemic disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11831",
    "question": "What is associated with Increased CSF methionine concentration?",
    "seeds": [
      "Increased CSF methionine concentration"
    ],
    "gold_answer": "Abnormal CSF aspartate family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11832",
    "question": "What phenotype is associated with Developmental malformations-deafness-dystonia syndrome?",
    "seeds": [
      "Developmental malformations-deafness-dystonia syndrome"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11833",
    "question": "What is associated with Elevated mitochondrial citrate synthase activity?",
    "seeds": [
      "Elevated mitochondrial citrate synthase activity"
    ],
    "gold_answer": "Abnormal enzyme activity in muscle tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11834",
    "question": "What is associated with Widened metacarpal shaft?",
    "seeds": [
      "Widened metacarpal shaft"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11835",
    "question": "What is associated with Alveolar ridge overgrowth?",
    "seeds": [
      "Alveolar ridge overgrowth"
    ],
    "gold_answer": "Abnormal alveolar ridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11836",
    "question": "What is associated with Repetitive compulsive behavior?",
    "seeds": [
      "Repetitive compulsive behavior"
    ],
    "gold_answer": "Restricted or repetitive behaviors or interests",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11837",
    "question": "What is associated with Abnormal circulating heparan sulfate level?",
    "seeds": [
      "Abnormal circulating heparan sulfate level"
    ],
    "gold_answer": "Abnormal circulating carbohydrate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11838",
    "question": "What is associated with Narrow pelvis bone?",
    "seeds": [
      "Narrow pelvis bone"
    ],
    "gold_answer": "Abnormal pelvis bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11839",
    "question": "What is associated with Central scotoma?",
    "seeds": [
      "Central scotoma"
    ],
    "gold_answer": "Scotoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11840",
    "question": "What is associated with Elevated urinary indoleacetic acid level?",
    "seeds": [
      "Elevated urinary indoleacetic acid level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11841",
    "question": "What is associated with Limited foot inversion?",
    "seeds": [
      "Limited foot inversion"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11842",
    "question": "What is associated with Superficial CNS hemosiderin deposition?",
    "seeds": [
      "Superficial CNS hemosiderin deposition"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11843",
    "question": "What phenotype is associated with Robin sequence-oligodactyly syndrome?",
    "seeds": [
      "Robin sequence-oligodactyly syndrome"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11844",
    "question": "What is associated with Abnormal lateral semicircular canal morphology?",
    "seeds": [
      "Abnormal lateral semicircular canal morphology"
    ],
    "gold_answer": "Abnormal inner ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11845",
    "question": "What is associated with Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter?",
    "seeds": [
      "Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11846",
    "question": "What is associated with Discordant atrioventricular connection?",
    "seeds": [
      "Discordant atrioventricular connection"
    ],
    "gold_answer": "Abnormal connection of the cardiac segments",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11847",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease type 1B?",
    "seeds": [
      "Charcot-Marie-Tooth disease type 1B"
    ],
    "gold_answer": "Peripheral axonal neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11848",
    "question": "What is associated with Vaginal fish odor?",
    "seeds": [
      "Vaginal fish odor"
    ],
    "gold_answer": "Body odor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11849",
    "question": "What is associated with Sandal gap?",
    "seeds": [
      "Sandal gap"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11850",
    "question": "What is associated with Abnormality of fibrinolysis?",
    "seeds": [
      "Abnormality of fibrinolysis"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11851",
    "question": "What is associated with Complete duplication of the phalanges of the 3rd finger?",
    "seeds": [
      "Complete duplication of the phalanges of the 3rd finger"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11852",
    "question": "What phenotype is associated with Multiple system atrophy 1, susceptibility to?",
    "seeds": [
      "Multiple system atrophy 1, susceptibility to"
    ],
    "gold_answer": "Urinary incontinence",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11853",
    "question": "What is associated with Waardenburg syndrome type 3?",
    "seeds": [
      "Waardenburg syndrome type 3"
    ],
    "gold_answer": "Generalized hypopigmentation of hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11854",
    "question": "What is associated with Elevated cancer Ag 19-9 level?",
    "seeds": [
      "Elevated cancer Ag 19-9 level"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11855",
    "question": "What is associated with Myositis?",
    "seeds": [
      "Myositis"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11856",
    "question": "What is associated with Pontine tegmental cap?",
    "seeds": [
      "Pontine tegmental cap"
    ],
    "gold_answer": "Abnormal pons morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11857",
    "question": "What phenotype is associated with Osteopetrosis, autosomal recessive 3?",
    "seeds": [
      "Osteopetrosis, autosomal recessive 3"
    ],
    "gold_answer": "Dental malocclusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11858",
    "question": "What phenotype is associated with Autoinflammation, panniculitis, and dermatosis syndrome?",
    "seeds": [
      "Autoinflammation, panniculitis, and dermatosis syndrome"
    ],
    "gold_answer": "Increased CD4+ T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11859",
    "question": "What phenotype is associated with Microphthalmia, syndromic 3?",
    "seeds": [
      "Microphthalmia, syndromic 3"
    ],
    "gold_answer": "Hemivertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11860",
    "question": "What is associated with Aplasia of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Aplasia of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Aplasia/hypoplasia of proximal toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11861",
    "question": "What is associated with Addictive amphetamine use?",
    "seeds": [
      "Addictive amphetamine use"
    ],
    "gold_answer": "Addictive substance use",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11862",
    "question": "What is associated with Progressive myoclonic epilepsy with dystonia?",
    "seeds": [
      "Progressive myoclonic epilepsy with dystonia"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11863",
    "question": "What is associated with Talipes equinovarus?",
    "seeds": [
      "Talipes equinovarus"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11864",
    "question": "What phenotype is associated with Neutrophilic dermatosis, acute febrile?",
    "seeds": [
      "Neutrophilic dermatosis, acute febrile"
    ],
    "gold_answer": "Skin vesicle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11865",
    "question": "What is associated with Glaucoma 1, open angle, F?",
    "seeds": [
      "Glaucoma 1, open angle, F"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11866",
    "question": "What is associated with Scanning speech?",
    "seeds": [
      "Scanning speech"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11867",
    "question": "What is associated with Diminished PMS2 expression?",
    "seeds": [
      "Diminished PMS2 expression"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11868",
    "question": "What is associated with Spermatogenic failure 15?",
    "seeds": [
      "Spermatogenic failure 15"
    ],
    "gold_answer": "Abnormal circulating sex hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11869",
    "question": "What is associated with Neuropathy, hereditary sensory and autonomic, type II?",
    "seeds": [
      "Neuropathy, hereditary sensory and autonomic, type II"
    ],
    "gold_answer": "Increased susceptibility to fractures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11870",
    "question": "What is associated with Conjugated hyperbilirubinemia?",
    "seeds": [
      "Conjugated hyperbilirubinemia"
    ],
    "gold_answer": "Hyperbilirubinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11871",
    "question": "What phenotype is associated with Dihydropyrimidine dehydrogenase deficiency?",
    "seeds": [
      "Dihydropyrimidine dehydrogenase deficiency"
    ],
    "gold_answer": "Reduced dihydropyrimidine dehydrogenase level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11872",
    "question": "What is associated with ANK3-related intellectual disability-sleep disturbance syndrome?",
    "seeds": [
      "ANK3-related intellectual disability-sleep disturbance syndrome"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11873",
    "question": "What is associated with Mitral valve leaflet calcification?",
    "seeds": [
      "Mitral valve leaflet calcification"
    ],
    "gold_answer": "Cardiac valve calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11874",
    "question": "What is associated with Lymphocytic infiltration of the parotid gland?",
    "seeds": [
      "Lymphocytic infiltration of the parotid gland"
    ],
    "gold_answer": "Abnormal parotid gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11875",
    "question": "What is associated with Reduced bone mineral density?",
    "seeds": [
      "Reduced bone mineral density"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11876",
    "question": "What is associated with Round radial epiphyses?",
    "seeds": [
      "Round radial epiphyses"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11877",
    "question": "What is associated with Ear exostoses?",
    "seeds": [
      "Ear exostoses"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11878",
    "question": "What is associated with Abnormal scalp morphology?",
    "seeds": [
      "Abnormal scalp morphology"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11879",
    "question": "What is associated with Abnormal respiratory system physiology?",
    "seeds": [
      "Abnormal respiratory system physiology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11880",
    "question": "What is associated with Hyperinsulinism due to UCP2 deficiency?",
    "seeds": [
      "Hyperinsulinism due to UCP2 deficiency"
    ],
    "gold_answer": "Hypohidrosis or hyperhidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11881",
    "question": "What is associated with Charcot-Marie-Tooth disease, demyelinating, type 1G?",
    "seeds": [
      "Charcot-Marie-Tooth disease, demyelinating, type 1G"
    ],
    "gold_answer": "Abnormality of peripheral nerve conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11882",
    "question": "What is associated with Central retinal exudate?",
    "seeds": [
      "Central retinal exudate"
    ],
    "gold_answer": "Yellow/white retinal lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11883",
    "question": "What is associated with Abnormal capitate bone morphology?",
    "seeds": [
      "Abnormal capitate bone morphology"
    ],
    "gold_answer": "Abnormal carpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11884",
    "question": "What is associated with X-linked Charcot-Marie-Tooth disease type 6?",
    "seeds": [
      "X-linked Charcot-Marie-Tooth disease type 6"
    ],
    "gold_answer": "Abnormality of the musculature of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11885",
    "question": "What is associated with Abnormality of angular artery?",
    "seeds": [
      "Abnormality of angular artery"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11886",
    "question": "What is associated with Abnormal circulating retinol-binding protein concentration?",
    "seeds": [
      "Abnormal circulating retinol-binding protein concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11887",
    "question": "What is associated with Maturity-onset diabetes of the young, type 10?",
    "seeds": [
      "Maturity-onset diabetes of the young, type 10"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11888",
    "question": "What is associated with Social anxiety?",
    "seeds": [
      "Social anxiety"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11889",
    "question": "What is associated with Atypical nevi in non-sun exposed areas?",
    "seeds": [
      "Atypical nevi in non-sun exposed areas"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11890",
    "question": "What phenotype is associated with Megaloblastic anemia 1?",
    "seeds": [
      "Megaloblastic anemia 1"
    ],
    "gold_answer": "Paresthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11891",
    "question": "What is associated with Decreased memory T cell proportion?",
    "seeds": [
      "Decreased memory T cell proportion"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11892",
    "question": "What is associated with Abnormality of the wrist?",
    "seeds": [
      "Abnormality of the wrist"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11893",
    "question": "What is associated with Berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification?",
    "seeds": [
      "Berry aneurysm, cirrhosis, pulmonary emphysema, and cerebral calcification"
    ],
    "gold_answer": "Cerebral calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11894",
    "question": "What is associated with Invasive pulmonary aspergillosis?",
    "seeds": [
      "Invasive pulmonary aspergillosis"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11895",
    "question": "What is associated with Abnormal full-field electroretinogram?",
    "seeds": [
      "Abnormal full-field electroretinogram"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11896",
    "question": "What is associated with Rib spur?",
    "seeds": [
      "Rib spur"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11897",
    "question": "What is associated with Abnormal total natural killer cell count?",
    "seeds": [
      "Abnormal total natural killer cell count"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11898",
    "question": "What is associated with Increased circulating N-acetylaspartic acid concentration?",
    "seeds": [
      "Increased circulating N-acetylaspartic acid concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11899",
    "question": "What is associated with Neurodevelopmental disorder with language delay and variable cognitive abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with language delay and variable cognitive abnormalities"
    ],
    "gold_answer": "Finger clinodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11900",
    "question": "What is associated with Reduced beta/alpha synthesis ratio?",
    "seeds": [
      "Reduced beta/alpha synthesis ratio"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11901",
    "question": "What is associated with Urticaria, aquagenic?",
    "seeds": [
      "Urticaria, aquagenic"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11902",
    "question": "What is associated with Medial rotation of the medial malleolus?",
    "seeds": [
      "Medial rotation of the medial malleolus"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11903",
    "question": "What phenotype is associated with Intellectual disability-hypotonic facies syndrome, X-linked?",
    "seeds": [
      "Intellectual disability-hypotonic facies syndrome, X-linked"
    ],
    "gold_answer": "Tapered finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11904",
    "question": "What is associated with Clavicular pseudarthrosis?",
    "seeds": [
      "Clavicular pseudarthrosis"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11905",
    "question": "What is associated with Early young adult onset?",
    "seeds": [
      "Early young adult onset"
    ],
    "gold_answer": "Young adult onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11906",
    "question": "What is associated with Triphalangeal thumb?",
    "seeds": [
      "Triphalangeal thumb"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11907",
    "question": "What is associated with Cutaneous syndactyly?",
    "seeds": [
      "Cutaneous syndactyly"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11908",
    "question": "What is associated with Decreased circulating fetuin A concentration?",
    "seeds": [
      "Decreased circulating fetuin A concentration"
    ],
    "gold_answer": "Abnormal circulating fetuin A concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11909",
    "question": "What is associated with Dysharmonic delayed bone age?",
    "seeds": [
      "Dysharmonic delayed bone age"
    ],
    "gold_answer": "Abnormality of skeletal maturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11910",
    "question": "What is associated with Generalized morning stiffness?",
    "seeds": [
      "Generalized morning stiffness"
    ],
    "gold_answer": "Joint stiffness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11911",
    "question": "What is associated with Retinitis pigmentosa 51?",
    "seeds": [
      "Retinitis pigmentosa 51"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11912",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 112?",
    "seeds": [
      "Developmental and epileptic encephalopathy 112"
    ],
    "gold_answer": "Chiari type I malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11913",
    "question": "What is associated with Abnormal dental enamel morphology?",
    "seeds": [
      "Abnormal dental enamel morphology"
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11914",
    "question": "What is associated with Lymph node abscess?",
    "seeds": [
      "Lymph node abscess"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11915",
    "question": "What is associated with Reduced left ventricular ejection fraction?",
    "seeds": [
      "Reduced left ventricular ejection fraction"
    ],
    "gold_answer": "Abnormal left ventricular ejection fraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11916",
    "question": "What is associated with Brugada syndrome 1?",
    "seeds": [
      "Brugada syndrome 1"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11917",
    "question": "What is associated with Retinal arteriolar tortuosity?",
    "seeds": [
      "Retinal arteriolar tortuosity"
    ],
    "gold_answer": "Retinal vascular tortuosity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11918",
    "question": "What is associated with Lack of pupillary response to hydroxyamphetamine?",
    "seeds": [
      "Lack of pupillary response to hydroxyamphetamine"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11919",
    "question": "What is associated with Large vessel vasculitis?",
    "seeds": [
      "Large vessel vasculitis"
    ],
    "gold_answer": "Vasculitis by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11920",
    "question": "What is associated with Diabetic ketoacidosis?",
    "seeds": [
      "Diabetic ketoacidosis"
    ],
    "gold_answer": "Diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11921",
    "question": "What is associated with 3-Methylglutaric aciduria?",
    "seeds": [
      "3-Methylglutaric aciduria"
    ],
    "gold_answer": "Abnormal urine carboxylic acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11922",
    "question": "What is associated with Aplasia/Hypoplasia of the ovary?",
    "seeds": [
      "Aplasia/Hypoplasia of the ovary"
    ],
    "gold_answer": "Abnormality of the ovary",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11923",
    "question": "What is associated with Ectodermal dysplasia-natal teeth-skin abscesses-plantar hyperkeratosis-hearing impairment?",
    "seeds": [
      "Ectodermal dysplasia-natal teeth-skin abscesses-plantar hyperkeratosis-hearing impairment"
    ],
    "gold_answer": "IRF6",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_11924",
    "question": "What is associated with Ameliorated by ketogenic diet?",
    "seeds": [
      "Ameliorated by ketogenic diet"
    ],
    "gold_answer": "Ameliorated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11925",
    "question": "What is associated with Abnormal cardiac catheterization?",
    "seeds": [
      "Abnormal cardiac catheterization"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11926",
    "question": "What is associated with Curvilinear pericallosal lipoma?",
    "seeds": [
      "Curvilinear pericallosal lipoma"
    ],
    "gold_answer": "Midline central nervous system lipomas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11927",
    "question": "What is associated with Low femoral bone density?",
    "seeds": [
      "Low femoral bone density"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11928",
    "question": "What phenotype is associated with 46,xx sex reversal 4?",
    "seeds": [
      "46,xx sex reversal 4"
    ],
    "gold_answer": "Ovotestis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11929",
    "question": "What is associated with Unbalanced atrioventricular canal defect?",
    "seeds": [
      "Unbalanced atrioventricular canal defect"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11930",
    "question": "What is associated with Proteinuria?",
    "seeds": [
      "Proteinuria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11931",
    "question": "What is associated with Atrophic fundus lesion?",
    "seeds": [
      "Atrophic fundus lesion"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11932",
    "question": "What is associated with Triangular shaped proximal phalanx of the 5th finger?",
    "seeds": [
      "Triangular shaped proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Triangular shaped phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11933",
    "question": "What phenotype is associated with Congenital myopathy 5 with cardiomyopathy?",
    "seeds": [
      "Congenital myopathy 5 with cardiomyopathy"
    ],
    "gold_answer": "Increased endomysial connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11934",
    "question": "What is associated with Elevated circulating acetylcarnitine concentration?",
    "seeds": [
      "Elevated circulating acetylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11935",
    "question": "What is associated with Gastrostomy tube feeding in infancy?",
    "seeds": [
      "Gastrostomy tube feeding in infancy"
    ],
    "gold_answer": "Tube feeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11936",
    "question": "What is associated with Inappropriately low concentration of acetoacetate?",
    "seeds": [
      "Inappropriately low concentration of acetoacetate"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11937",
    "question": "What is associated with Double first metacarpals?",
    "seeds": [
      "Double first metacarpals"
    ],
    "gold_answer": "Supernumerary metacarpal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11938",
    "question": "What is associated with Clumping of lymph node lymphocyte chromatin?",
    "seeds": [
      "Clumping of lymph node lymphocyte chromatin"
    ],
    "gold_answer": "Abnormal lymph-node cellular finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11939",
    "question": "What is associated with Orange discolored tonsils?",
    "seeds": [
      "Orange discolored tonsils"
    ],
    "gold_answer": "Abnormality of the tonsils",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11940",
    "question": "What is associated with Leber optic atrophy and dystonia?",
    "seeds": [
      "Leber optic atrophy and dystonia"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11941",
    "question": "What is associated with Biconvex vertebral bodies?",
    "seeds": [
      "Biconvex vertebral bodies"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11942",
    "question": "What is associated with Epilepsy, familial adult myoclonic, 7?",
    "seeds": [
      "Epilepsy, familial adult myoclonic, 7"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11943",
    "question": "What is associated with Abnormal distribution of CD56 bright/dim natural killer cells?",
    "seeds": [
      "Abnormal distribution of CD56 bright/dim natural killer cells"
    ],
    "gold_answer": "Abnormal natural killer subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11944",
    "question": "What is associated with Abnormal waist to hip ratio?",
    "seeds": [
      "Abnormal waist to hip ratio"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11945",
    "question": "What is associated with Mandibuloacral dysplasia with type B lipodystrophy?",
    "seeds": [
      "Mandibuloacral dysplasia with type B lipodystrophy"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11946",
    "question": "What phenotype is associated with Neuropathy, hereditary sensory, type ID?",
    "seeds": [
      "Neuropathy, hereditary sensory, type ID"
    ],
    "gold_answer": "Autoamputation of digits",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11947",
    "question": "What is associated with Elevated placental alkaline phosphatase?",
    "seeds": [
      "Elevated placental alkaline phosphatase"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11948",
    "question": "What is associated with Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome due to TPP2 deficiency?",
    "seeds": [
      "Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome due to TPP2 deficiency"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11949",
    "question": "What phenotype is associated with 2-methylbutyryl-CoA dehydrogenase deficiency?",
    "seeds": [
      "2-methylbutyryl-CoA dehydrogenase deficiency"
    ],
    "gold_answer": "Elevated circulating C5 acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11950",
    "question": "What is associated with Lunate-triquetral fusion?",
    "seeds": [
      "Lunate-triquetral fusion"
    ],
    "gold_answer": "Abnormal lunate bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11951",
    "question": "What is associated with Anotia?",
    "seeds": [
      "Anotia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the external ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11952",
    "question": "What is associated with Gonadal hypoplasia?",
    "seeds": [
      "Gonadal hypoplasia"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11953",
    "question": "What is associated with Keratoconus 9?",
    "seeds": [
      "Keratoconus 9"
    ],
    "gold_answer": "Abnormality of the curvature of the cornea",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11954",
    "question": "What is associated with Lateral neck mass?",
    "seeds": [
      "Lateral neck mass"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11955",
    "question": "What is associated with Ullrich congenital muscular dystrophy?",
    "seeds": [
      "Ullrich congenital muscular dystrophy"
    ],
    "gold_answer": "Abnormal knee morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11956",
    "question": "What is associated with Testicular neoplasm?",
    "seeds": [
      "Testicular neoplasm"
    ],
    "gold_answer": "Neoplasm of the genitourinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11957",
    "question": "What is associated with Pseudoepiphysis of the 2nd finger?",
    "seeds": [
      "Pseudoepiphysis of the 2nd finger"
    ],
    "gold_answer": "Pseudoepiphyses of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11958",
    "question": "What is associated with Triggered by menstruation?",
    "seeds": [
      "Triggered by menstruation"
    ],
    "gold_answer": "Triggered by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11959",
    "question": "What is associated with Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome?",
    "seeds": [
      "Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the mandible",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11960",
    "question": "What is associated with Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia?",
    "seeds": [
      "Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia"
    ],
    "gold_answer": "Abnormal iliac wing morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11961",
    "question": "What is associated with Anoperineal fistula?",
    "seeds": [
      "Anoperineal fistula"
    ],
    "gold_answer": "Abnormality of temperature regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11962",
    "question": "What is associated with Abnormal pattern of respiration?",
    "seeds": [
      "Abnormal pattern of respiration"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11963",
    "question": "What is associated with Intellectual disability-balding-patella luxation-acromicria syndrome?",
    "seeds": [
      "Intellectual disability-balding-patella luxation-acromicria syndrome"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11964",
    "question": "What is associated with Progressive neurologic deterioration?",
    "seeds": [
      "Progressive neurologic deterioration"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11965",
    "question": "What is associated with Skin infectious agent?",
    "seeds": [
      "Skin infectious agent"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11966",
    "question": "What is associated with Pelvic girdle muscle atrophy?",
    "seeds": [
      "Pelvic girdle muscle atrophy"
    ],
    "gold_answer": "Abnormality of the hip-girdle musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11967",
    "question": "What is associated with Charcot-Marie-Tooth disease type 1A?",
    "seeds": [
      "Charcot-Marie-Tooth disease type 1A"
    ],
    "gold_answer": "Somatic sensory dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11968",
    "question": "What is associated with Yellow fever?",
    "seeds": [
      "Yellow fever"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11969",
    "question": "What is associated with Paraspinal hemangioma?",
    "seeds": [
      "Paraspinal hemangioma"
    ],
    "gold_answer": "Hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11970",
    "question": "What is associated with Abnormal circulating long-chain fatty-acid concentration?",
    "seeds": [
      "Abnormal circulating long-chain fatty-acid concentration"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11971",
    "question": "What is associated with Anomalous branches of internal carotid artery?",
    "seeds": [
      "Anomalous branches of internal carotid artery"
    ],
    "gold_answer": "Abnormal carotid artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11972",
    "question": "What is associated with Hereditary cerebral amyloid angiopathy?",
    "seeds": [
      "Hereditary cerebral amyloid angiopathy"
    ],
    "gold_answer": "Cognitive impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11973",
    "question": "What phenotype is associated with Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome?",
    "seeds": [
      "Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome"
    ],
    "gold_answer": "Dilated cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11974",
    "question": "What is associated with Widened mediastinum?",
    "seeds": [
      "Widened mediastinum"
    ],
    "gold_answer": "Abnormal mediastinum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11975",
    "question": "What is associated with Ocular albinism?",
    "seeds": [
      "Ocular albinism"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11976",
    "question": "What is associated with Edema of the dorsum of feet?",
    "seeds": [
      "Edema of the dorsum of feet"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11977",
    "question": "What is associated with Partial duplication of thumb phalanx?",
    "seeds": [
      "Partial duplication of thumb phalanx"
    ],
    "gold_answer": "Duplication of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11978",
    "question": "What is associated with Hurler-Scheie syndrome?",
    "seeds": [
      "Hurler-Scheie syndrome"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11979",
    "question": "What is associated with Decreased fucosylation of N-linked protein glycosylation?",
    "seeds": [
      "Decreased fucosylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11980",
    "question": "What is associated with DDX41-related hematologic malignancy predisposition syndrome?",
    "seeds": [
      "DDX41-related hematologic malignancy predisposition syndrome"
    ],
    "gold_answer": "DDX41",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_11981",
    "question": "What phenotype is associated with Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome?",
    "seeds": [
      "Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome"
    ],
    "gold_answer": "Choanal stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11982",
    "question": "What is associated with Wrist arthritis?",
    "seeds": [
      "Wrist arthritis"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11983",
    "question": "What is associated with Focal orofacial automatism seizure?",
    "seeds": [
      "Focal orofacial automatism seizure"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11984",
    "question": "What is associated with Positive urine methadone test?",
    "seeds": [
      "Positive urine methadone test"
    ],
    "gold_answer": "Presence of xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11985",
    "question": "What is associated with Filamentary keratitis?",
    "seeds": [
      "Filamentary keratitis"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11986",
    "question": "What is associated with Cardiomyopathy, dilated, with woolly hair and keratoderma?",
    "seeds": [
      "Cardiomyopathy, dilated, with woolly hair and keratoderma"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11987",
    "question": "What is associated with Mesomelia-Synostoses syndrome?",
    "seeds": [
      "Mesomelia-Synostoses syndrome"
    ],
    "gold_answer": "Dilatation of the renal pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11988",
    "question": "What is associated with Short proximal phalanx of the 4th finger?",
    "seeds": [
      "Short proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11989",
    "question": "What is associated with Congenital nephrotic syndrome?",
    "seeds": [
      "Congenital nephrotic syndrome"
    ],
    "gold_answer": "Nephrotic syndrome",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11990",
    "question": "What is associated with Anal margin squamous cell carcinoma?",
    "seeds": [
      "Anal margin squamous cell carcinoma"
    ],
    "gold_answer": "Anal margin neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11991",
    "question": "What is associated with Medial calcification of medium-sized arteries?",
    "seeds": [
      "Medial calcification of medium-sized arteries"
    ],
    "gold_answer": "Arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11992",
    "question": "What is associated with Vocal cord polyp?",
    "seeds": [
      "Vocal cord polyp"
    ],
    "gold_answer": "Abnormality of the larynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11993",
    "question": "What is associated with Silhouette sign?",
    "seeds": [
      "Silhouette sign"
    ],
    "gold_answer": "Pulmonary imaging sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11994",
    "question": "What is associated with Cutaneous abscess?",
    "seeds": [
      "Cutaneous abscess"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11995",
    "question": "What phenotype is associated with SHOX-related short stature?",
    "seeds": [
      "SHOX-related short stature"
    ],
    "gold_answer": "Ulnar radial head dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_11996",
    "question": "What is associated with Thyroid hormone metabolism, abnormal, 3?",
    "seeds": [
      "Thyroid hormone metabolism, abnormal, 3"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11997",
    "question": "What is associated with Shortened QT interval?",
    "seeds": [
      "Shortened QT interval"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11998",
    "question": "What is associated with Diminishment of emotional expression?",
    "seeds": [
      "Diminishment of emotional expression"
    ],
    "gold_answer": "Abnormal social behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_11999",
    "question": "What is associated with Hypoplasia of the abdominal wall musculature?",
    "seeds": [
      "Hypoplasia of the abdominal wall musculature"
    ],
    "gold_answer": "Abnormal morphology of the abdominal musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12000",
    "question": "What is associated with Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome?",
    "seeds": [
      "Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12001",
    "question": "What is associated with Myotonic dystrophy 1?",
    "seeds": [
      "Myotonic dystrophy 1"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12002",
    "question": "What phenotype is associated with Parkinsonism-dystonia, infantile, 2?",
    "seeds": [
      "Parkinsonism-dystonia, infantile, 2"
    ],
    "gold_answer": "Delayed ability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12003",
    "question": "What phenotype is associated with Waardenburg syndrome, type 3?",
    "seeds": [
      "Waardenburg syndrome, type 3"
    ],
    "gold_answer": "White eyelashes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12004",
    "question": "What is associated with Bullous diffuse cutaneous mastocytosis?",
    "seeds": [
      "Bullous diffuse cutaneous mastocytosis"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12005",
    "question": "What is associated with Lozenge-shaped umbilicus?",
    "seeds": [
      "Lozenge-shaped umbilicus"
    ],
    "gold_answer": "Abnormal umbilicus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12006",
    "question": "What is associated with Total intestinal aganglionosis?",
    "seeds": [
      "Total intestinal aganglionosis"
    ],
    "gold_answer": "Abnormal enteric nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12007",
    "question": "What is associated with Myoglobinuria?",
    "seeds": [
      "Myoglobinuria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12008",
    "question": "What is associated with Intraluminal meconium calcification?",
    "seeds": [
      "Intraluminal meconium calcification"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12009",
    "question": "What is associated with Deafness, autosomal dominant 40?",
    "seeds": [
      "Deafness, autosomal dominant 40"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12010",
    "question": "What phenotype is associated with Spondylocostal dysostosis 5?",
    "seeds": [
      "Spondylocostal dysostosis 5"
    ],
    "gold_answer": "Missing ribs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12011",
    "question": "What is associated with Cone-shaped epiphyses of the 3rd toe?",
    "seeds": [
      "Cone-shaped epiphyses of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12012",
    "question": "What is associated with Pancreatic cysts?",
    "seeds": [
      "Pancreatic cysts"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12013",
    "question": "What is associated with Pharyngalgia?",
    "seeds": [
      "Pharyngalgia"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12014",
    "question": "What is associated with Sialuria?",
    "seeds": [
      "Sialuria"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12015",
    "question": "What is associated with Abnormal hypoxanthine-guanine phosphoribosyltransferase level?",
    "seeds": [
      "Abnormal hypoxanthine-guanine phosphoribosyltransferase level"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12016",
    "question": "What is associated with Anomalous branches of internal carotid artery?",
    "seeds": [
      "Anomalous branches of internal carotid artery"
    ],
    "gold_answer": "Abnormal carotid artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12017",
    "question": "What is associated with ADAR-related hereditary spastic paraplegia?",
    "seeds": [
      "ADAR-related hereditary spastic paraplegia"
    ],
    "gold_answer": "ADAR",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12018",
    "question": "What is associated with Yellow nail syndrome?",
    "seeds": [
      "Yellow nail syndrome"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12019",
    "question": "What is associated with Multiple unerupted teeth?",
    "seeds": [
      "Multiple unerupted teeth"
    ],
    "gold_answer": "Abnormality of dental eruption",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12020",
    "question": "What is associated with Pontocerebellar hypoplasia type 1?",
    "seeds": [
      "Pontocerebellar hypoplasia type 1"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12021",
    "question": "What is associated with Glomerular amyloid subepithelial deposits?",
    "seeds": [
      "Glomerular amyloid subepithelial deposits"
    ],
    "gold_answer": "Fibrillar glomerular subepithelial deposits",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12022",
    "question": "What is associated with Aplasia/Hypoplasia involving the vertebral column?",
    "seeds": [
      "Aplasia/Hypoplasia involving the vertebral column"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12023",
    "question": "What phenotype is associated with Ring chromosome 13 syndrome?",
    "seeds": [
      "Ring chromosome 13 syndrome"
    ],
    "gold_answer": "Subretinal pigment epithelium hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12024",
    "question": "What phenotype is associated with Neurodevelopmental disorder with poor or absent speech, dysmorphic facies, and behavioral abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with poor or absent speech, dysmorphic facies, and behavioral abnormalities"
    ],
    "gold_answer": "Abnormal CNS myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12025",
    "question": "What is associated with Spermatogenic failure, X-linked 2?",
    "seeds": [
      "Spermatogenic failure, X-linked 2"
    ],
    "gold_answer": "Functional abnormality of male internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12026",
    "question": "What is associated with Epidermal acanthosis?",
    "seeds": [
      "Epidermal acanthosis"
    ],
    "gold_answer": "Abnormal epidermal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12027",
    "question": "What is associated with Thoracic ectopia cordis?",
    "seeds": [
      "Thoracic ectopia cordis"
    ],
    "gold_answer": "Abnormal anatomic location of the heart",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12028",
    "question": "What is associated with Right aortic arch with retroesophageal diverticulum of Kommerell?",
    "seeds": [
      "Right aortic arch with retroesophageal diverticulum of Kommerell"
    ],
    "gold_answer": "Abnormal aortic arch morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12029",
    "question": "What is associated with Abnormal capillary physiology?",
    "seeds": [
      "Abnormal capillary physiology"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12030",
    "question": "What is associated with Asymmetry of the size of ears?",
    "seeds": [
      "Asymmetry of the size of ears"
    ],
    "gold_answer": "Asymmetry of the ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12031",
    "question": "What phenotype is associated with Cholestasis, progressive familial intrahepatic, 3?",
    "seeds": [
      "Cholestasis, progressive familial intrahepatic, 3"
    ],
    "gold_answer": "Malabsorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12032",
    "question": "What is associated with Macular dystrophy, concentric annular?",
    "seeds": [
      "Macular dystrophy, concentric annular"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12033",
    "question": "What is associated with Perineal hemangioma?",
    "seeds": [
      "Perineal hemangioma"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12034",
    "question": "What is associated with Nephrolithiasis?",
    "seeds": [
      "Nephrolithiasis"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12035",
    "question": "What is associated with Adductor longus contractures?",
    "seeds": [
      "Adductor longus contractures"
    ],
    "gold_answer": "Lower-limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12036",
    "question": "What is associated with Abnormal erythrocyte metabolite concentration?",
    "seeds": [
      "Abnormal erythrocyte metabolite concentration"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12037",
    "question": "What is associated with Mesomelic dwarfism, Reinhardt-Pfeiffer type?",
    "seeds": [
      "Mesomelic dwarfism, Reinhardt-Pfeiffer type"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12038",
    "question": "What is associated with Abnormal head movements?",
    "seeds": [
      "Abnormal head movements"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12039",
    "question": "What is associated with Tetany?",
    "seeds": [
      "Tetany"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12040",
    "question": "What phenotype is associated with Achalasia-microcephaly syndrome?",
    "seeds": [
      "Achalasia-microcephaly syndrome"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12041",
    "question": "What is associated with Myopia 2, autosomal dominant?",
    "seeds": [
      "Myopia 2, autosomal dominant"
    ],
    "gold_answer": "Myopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12042",
    "question": "What is associated with Recurrent pyelonephritis?",
    "seeds": [
      "Recurrent pyelonephritis"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12043",
    "question": "What is associated with Atrial reentry tachycardia?",
    "seeds": [
      "Atrial reentry tachycardia"
    ],
    "gold_answer": "Atrial arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12044",
    "question": "What is associated with Peripheral arterial calcification?",
    "seeds": [
      "Peripheral arterial calcification"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12045",
    "question": "What is associated with Inferior oblique muscle weakness?",
    "seeds": [
      "Inferior oblique muscle weakness"
    ],
    "gold_answer": "Abnormal inferior oblique muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12046",
    "question": "What is associated with Mesangial proliferative lupus nephritis?",
    "seeds": [
      "Mesangial proliferative lupus nephritis"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12047",
    "question": "What is associated with Ribose 5-phosphate isomerase deficiency?",
    "seeds": [
      "Ribose 5-phosphate isomerase deficiency"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12048",
    "question": "What is associated with Recurrent meningitis?",
    "seeds": [
      "Recurrent meningitis"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12049",
    "question": "What is associated with Premature epimetaphyseal fusion in radius?",
    "seeds": [
      "Premature epimetaphyseal fusion in radius"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12050",
    "question": "What phenotype is associated with Opitz-Kaveggia syndrome?",
    "seeds": [
      "Opitz-Kaveggia syndrome"
    ],
    "gold_answer": "Split hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12051",
    "question": "What is associated with Generalized non-motor (absence) seizure?",
    "seeds": [
      "Generalized non-motor (absence) seizure"
    ],
    "gold_answer": "Non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12052",
    "question": "What is associated with Lymph-node follicular sclerosis?",
    "seeds": [
      "Lymph-node follicular sclerosis"
    ],
    "gold_answer": "Abnormal lymph-node follicle architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12053",
    "question": "What is associated with Direct antiglobulin test positive for C3d?",
    "seeds": [
      "Direct antiglobulin test positive for C3d"
    ],
    "gold_answer": "Positive Coombs test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12054",
    "question": "What is associated with Hypogonadotropic hypogonadism 4 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 4 with or without anosmia"
    ],
    "gold_answer": "Abnormality of the menstrual cycle",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12055",
    "question": "What is associated with Glabellar hemangioma?",
    "seeds": [
      "Glabellar hemangioma"
    ],
    "gold_answer": "Vascular neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12056",
    "question": "What is associated with Impaired renal tubular reabsorption of low molecular weight protein?",
    "seeds": [
      "Impaired renal tubular reabsorption of low molecular weight protein"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12057",
    "question": "What is associated with Purely bicuspid aortic valve?",
    "seeds": [
      "Purely bicuspid aortic valve"
    ],
    "gold_answer": "Abnormal aortic valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12058",
    "question": "What is associated with Focal impaired awareness seizure with dissociation at onset?",
    "seeds": [
      "Focal impaired awareness seizure with dissociation at onset"
    ],
    "gold_answer": "Focal impaired awareness cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12059",
    "question": "What is associated with Abnormality of the epiphysis of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Abnormality of the epiphysis of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12060",
    "question": "What phenotype is associated with Developmental delay with or without dysmorphic facies and autism?",
    "seeds": [
      "Developmental delay with or without dysmorphic facies and autism"
    ],
    "gold_answer": "Delayed ability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12061",
    "question": "What is associated with Dopa-responsive dystonia due to sepiapterin reductase deficiency?",
    "seeds": [
      "Dopa-responsive dystonia due to sepiapterin reductase deficiency"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12062",
    "question": "What phenotype is associated with Charcot-Marie-Tooth peroneal muscular atrophy, X-linked, with aplasia?",
    "seeds": [
      "Charcot-Marie-Tooth peroneal muscular atrophy, X-linked, with aplasia"
    ],
    "gold_answer": "Motor axonal neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12063",
    "question": "What is associated with Severe viral infection?",
    "seeds": [
      "Severe viral infection"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12064",
    "question": "What is associated with Albinism, oculocutaneous, type V?",
    "seeds": [
      "Albinism, oculocutaneous, type V"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12065",
    "question": "What is associated with Impaired vibratory sensation?",
    "seeds": [
      "Impaired vibratory sensation"
    ],
    "gold_answer": "Somatic sensory dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12066",
    "question": "What is associated with Exercise-induced rhabdomyolysis?",
    "seeds": [
      "Exercise-induced rhabdomyolysis"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12067",
    "question": "What is associated with Skeletal dysplasia?",
    "seeds": [
      "Skeletal dysplasia"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12068",
    "question": "What is associated with Ciliary discoordination due to random ciliary orientation?",
    "seeds": [
      "Ciliary discoordination due to random ciliary orientation"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12069",
    "question": "What is associated with Abnormal class-switched memory B cell proportion?",
    "seeds": [
      "Abnormal class-switched memory B cell proportion"
    ],
    "gold_answer": "Abnormal B cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12070",
    "question": "What is associated with Anomalous origin of the left common carotid artery from the main pulmonary artery?",
    "seeds": [
      "Anomalous origin of the left common carotid artery from the main pulmonary artery"
    ],
    "gold_answer": "Abnormal carotid artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12071",
    "question": "What is associated with Postauricular skin tag?",
    "seeds": [
      "Postauricular skin tag"
    ],
    "gold_answer": "Abnormal cheek morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12072",
    "question": "What is associated with Anti-AMPAR antibody positivity?",
    "seeds": [
      "Anti-AMPAR antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12073",
    "question": "What is associated with Idiopathic steroid-resistant nephrotic syndrome?",
    "seeds": [
      "Idiopathic steroid-resistant nephrotic syndrome"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12074",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 73?",
    "seeds": [
      "Developmental and epileptic encephalopathy 73"
    ],
    "gold_answer": "Inguinal hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12075",
    "question": "What is associated with Increased urine urobilinogen?",
    "seeds": [
      "Increased urine urobilinogen"
    ],
    "gold_answer": "Abnormal urine urobilinogen level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12076",
    "question": "What is associated with Abnormal arachnoid mater morphology?",
    "seeds": [
      "Abnormal arachnoid mater morphology"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12077",
    "question": "What is associated with Abnormal urine metabolite level?",
    "seeds": [
      "Abnormal urine metabolite level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12078",
    "question": "What phenotype is associated with Antiphospholipid syndrome, familial?",
    "seeds": [
      "Antiphospholipid syndrome, familial"
    ],
    "gold_answer": "Visual loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12079",
    "question": "What is associated with X-linked intellectual disability, Schimke type?",
    "seeds": [
      "X-linked intellectual disability, Schimke type"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12080",
    "question": "What phenotype is associated with Thyroid hormone plasma membrane transport defect?",
    "seeds": [
      "Thyroid hormone plasma membrane transport defect"
    ],
    "gold_answer": "Goiter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12081",
    "question": "What phenotype is associated with TMEM70-related mitochondrial encephalo-cardio-myopathy?",
    "seeds": [
      "TMEM70-related mitochondrial encephalo-cardio-myopathy"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12082",
    "question": "What is associated with Spinal canal stenosis?",
    "seeds": [
      "Spinal canal stenosis"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12083",
    "question": "What is associated with Horizontal opticokinetic nystagmus?",
    "seeds": [
      "Horizontal opticokinetic nystagmus"
    ],
    "gold_answer": "Horizontal nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12084",
    "question": "What is associated with Abnormal vaginal discharge?",
    "seeds": [
      "Abnormal vaginal discharge"
    ],
    "gold_answer": "Abnormal female reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12085",
    "question": "What is associated with Altman type III sacrococcygeal teratoma?",
    "seeds": [
      "Altman type III sacrococcygeal teratoma"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12086",
    "question": "What phenotype is associated with Bile acid synthesis defect, congenital, 3?",
    "seeds": [
      "Bile acid synthesis defect, congenital, 3"
    ],
    "gold_answer": "Jaundice",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12087",
    "question": "What is associated with Increased circulating copper concentration?",
    "seeds": [
      "Increased circulating copper concentration"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12088",
    "question": "What is associated with Verrucous hemangioma?",
    "seeds": [
      "Verrucous hemangioma"
    ],
    "gold_answer": "Hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12089",
    "question": "What phenotype is associated with Hyperhidrosis palmaris et plantaris?",
    "seeds": [
      "Hyperhidrosis palmaris et plantaris"
    ],
    "gold_answer": "Palmoplantar hyperhidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12090",
    "question": "What is associated with Transverse fracture?",
    "seeds": [
      "Transverse fracture"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12091",
    "question": "What is associated with Peroxisome biogenesis disorder 10A (Zellweger)?",
    "seeds": [
      "Peroxisome biogenesis disorder 10A (Zellweger)"
    ],
    "gold_answer": "Slanting of the palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12092",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 114?",
    "seeds": [
      "Developmental and epileptic encephalopathy 114"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12093",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 28?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 28"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12094",
    "question": "What is associated with Tibia, hypoplasia or aplasia of, with polydactyly?",
    "seeds": [
      "Tibia, hypoplasia or aplasia of, with polydactyly"
    ],
    "gold_answer": "Polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12095",
    "question": "What is associated with Juvenile rheumatoid arthritis?",
    "seeds": [
      "Juvenile rheumatoid arthritis"
    ],
    "gold_answer": "Rheumatoid arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12096",
    "question": "What is associated with SPONDYLOEPIMETAPHYSEAL DYSPLASIA, MICROMELIC?",
    "seeds": [
      "SPONDYLOEPIMETAPHYSEAL DYSPLASIA, MICROMELIC"
    ],
    "gold_answer": "Skeletal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12097",
    "question": "What is associated with Developmental and epileptic encephalopathy 44?",
    "seeds": [
      "Developmental and epileptic encephalopathy 44"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12098",
    "question": "What is associated with Van Maldergem syndrome 1?",
    "seeds": [
      "Van Maldergem syndrome 1"
    ],
    "gold_answer": "Abnormality of upper lip vermillion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12099",
    "question": "What is associated with Abdominal guarding?",
    "seeds": [
      "Abdominal guarding"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12100",
    "question": "What is associated with Coarse facial features?",
    "seeds": [
      "Coarse facial features"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12101",
    "question": "What is associated with Pretibial dimple?",
    "seeds": [
      "Pretibial dimple"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12102",
    "question": "What is associated with Regional abnormality of skin?",
    "seeds": [
      "Regional abnormality of skin"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12103",
    "question": "What is associated with Severe receptive language delay?",
    "seeds": [
      "Severe receptive language delay"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12104",
    "question": "What is associated with Accumulation of melanosomes in melanocytes?",
    "seeds": [
      "Accumulation of melanosomes in melanocytes"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12105",
    "question": "What is associated with Nasal secretion neutrophilia?",
    "seeds": [
      "Nasal secretion neutrophilia"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12106",
    "question": "What is associated with Amplification of comfort with casual physical contact?",
    "seeds": [
      "Amplification of comfort with casual physical contact"
    ],
    "gold_answer": "Abnormal social behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12107",
    "question": "What phenotype is associated with Geleophysic dysplasia 1?",
    "seeds": [
      "Geleophysic dysplasia 1"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12108",
    "question": "What is associated with Retinal gliosis?",
    "seeds": [
      "Retinal gliosis"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12109",
    "question": "What is associated with Abnormality of uvular muscle?",
    "seeds": [
      "Abnormality of uvular muscle"
    ],
    "gold_answer": "Abnormality of musculature of soft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12110",
    "question": "What is associated with Short pointed phalanges?",
    "seeds": [
      "Short pointed phalanges"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12111",
    "question": "What is associated with Hypoplasia of the premaxilla?",
    "seeds": [
      "Hypoplasia of the premaxilla"
    ],
    "gold_answer": "Abnormal maxilla morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12112",
    "question": "What phenotype is associated with Ulna metaphyseal dysplasia syndrome?",
    "seeds": [
      "Ulna metaphyseal dysplasia syndrome"
    ],
    "gold_answer": "Hypercalcemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12113",
    "question": "What is associated with Prolonged miniature endplate currents?",
    "seeds": [
      "Prolonged miniature endplate currents"
    ],
    "gold_answer": "Abnormal peripheral nervous system synaptic transmission",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12114",
    "question": "What is associated with Abnormal aortic valve physiology?",
    "seeds": [
      "Abnormal aortic valve physiology"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12115",
    "question": "What is associated with Abnormal left ventricular function?",
    "seeds": [
      "Abnormal left ventricular function"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12116",
    "question": "What is associated with Cotton wool plaques?",
    "seeds": [
      "Cotton wool plaques"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12117",
    "question": "What phenotype is associated with Neurodevelopmental disorder plus optic atrophy?",
    "seeds": [
      "Neurodevelopmental disorder plus optic atrophy"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12118",
    "question": "What is associated with Elevated brain glycine level by MRS?",
    "seeds": [
      "Elevated brain glycine level by MRS"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12119",
    "question": "What is associated with Peptic ulcer?",
    "seeds": [
      "Peptic ulcer"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12120",
    "question": "What is associated with Fractured hamate bone?",
    "seeds": [
      "Fractured hamate bone"
    ],
    "gold_answer": "Fractured hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12121",
    "question": "What is associated with Coronary ostial atresia?",
    "seeds": [
      "Coronary ostial atresia"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12122",
    "question": "What is associated with Abnormal response to glucagon stimulation test?",
    "seeds": [
      "Abnormal response to glucagon stimulation test"
    ],
    "gold_answer": "Abnormal response to endocrine stimulation test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12123",
    "question": "What phenotype is associated with Brain malformation-congenital heart disease-postaxial polydactyly syndrome?",
    "seeds": [
      "Brain malformation-congenital heart disease-postaxial polydactyly syndrome"
    ],
    "gold_answer": "Alopecia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12124",
    "question": "What is associated with von Hippel-Lindau syndrome?",
    "seeds": [
      "von Hippel-Lindau syndrome"
    ],
    "gold_answer": "Vascular neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12125",
    "question": "What is associated with Enteric neuronal degeneration?",
    "seeds": [
      "Enteric neuronal degeneration"
    ],
    "gold_answer": "Abnormal enteric nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12126",
    "question": "What is associated with Chorioretinal atrophy?",
    "seeds": [
      "Chorioretinal atrophy"
    ],
    "gold_answer": "Abnormal choroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12127",
    "question": "What is associated with Abnormal optic nerve morphology?",
    "seeds": [
      "Abnormal optic nerve morphology"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12128",
    "question": "What is associated with Abnormal neck blood vessel morphology?",
    "seeds": [
      "Abnormal neck blood vessel morphology"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12129",
    "question": "What is associated with Commissural lip pit?",
    "seeds": [
      "Commissural lip pit"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12130",
    "question": "What is associated with Hiatt-Neu-Cooper neurodevelopmental syndrome?",
    "seeds": [
      "Hiatt-Neu-Cooper neurodevelopmental syndrome"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12131",
    "question": "What is associated with Abnormal fetal nasal bone visualization?",
    "seeds": [
      "Abnormal fetal nasal bone visualization"
    ],
    "gold_answer": "Abnormal fetal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12132",
    "question": "What is associated with Cerebellar, ocular, craniofacial, and genital syndrome?",
    "seeds": [
      "Cerebellar, ocular, craniofacial, and genital syndrome"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12133",
    "question": "What is associated with Recurrent viral infections?",
    "seeds": [
      "Recurrent viral infections"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12134",
    "question": "What is associated with Urofacial syndrome?",
    "seeds": [
      "Urofacial syndrome"
    ],
    "gold_answer": "Increased blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12135",
    "question": "What is associated with Marker expression?",
    "seeds": [
      "Marker expression"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12136",
    "question": "What is associated with Ureteral obstruction?",
    "seeds": [
      "Ureteral obstruction"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12137",
    "question": "What is associated with Cone-shaped epiphysis of the middle phalanx of the 4th toe?",
    "seeds": [
      "Cone-shaped epiphysis of the middle phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the middle phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12138",
    "question": "What is associated with Bartholin cyst?",
    "seeds": [
      "Bartholin cyst"
    ],
    "gold_answer": "Abnormal female external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12139",
    "question": "What is associated with Choreoathetosis, hypothyroidism, and neonatal respiratory distress?",
    "seeds": [
      "Choreoathetosis, hypothyroidism, and neonatal respiratory distress"
    ],
    "gold_answer": "Abnormal response to endocrine stimulation test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12140",
    "question": "What is associated with Spermatogenic failure 83?",
    "seeds": [
      "Spermatogenic failure 83"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12141",
    "question": "What is associated with Narrow maxilla?",
    "seeds": [
      "Narrow maxilla"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12142",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 2?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 2"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12143",
    "question": "What is associated with Bladder cancer?",
    "seeds": [
      "Bladder cancer"
    ],
    "gold_answer": "Neoplasm of the genitourinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12144",
    "question": "What is associated with Abnormal unaided visual acuity test?",
    "seeds": [
      "Abnormal unaided visual acuity test"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12145",
    "question": "What is associated with Reduced epidermal extracellular matrix protein 1 protein expression?",
    "seeds": [
      "Reduced epidermal extracellular matrix protein 1 protein expression"
    ],
    "gold_answer": "Abnormal epidermal protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12146",
    "question": "What is associated with Reduced circulating urocanic acid concentration?",
    "seeds": [
      "Reduced circulating urocanic acid concentration"
    ],
    "gold_answer": "Abnormal circulating monocarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12147",
    "question": "What is associated with Exacerbated by tobacco use?",
    "seeds": [
      "Exacerbated by tobacco use"
    ],
    "gold_answer": "Aggravated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12148",
    "question": "What is associated with Abnormality of the respiratory system?",
    "seeds": [
      "Abnormality of the respiratory system"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12149",
    "question": "What is associated with Spondylolysis?",
    "seeds": [
      "Spondylolysis"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12150",
    "question": "What is associated with Achilles tendon tear?",
    "seeds": [
      "Achilles tendon tear"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12151",
    "question": "What phenotype is associated with Myoclonus-cerebellar ataxia-deafness syndrome?",
    "seeds": [
      "Myoclonus-cerebellar ataxia-deafness syndrome"
    ],
    "gold_answer": "Generalized amyotrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12152",
    "question": "What is associated with Abnormal epididymis morphology?",
    "seeds": [
      "Abnormal epididymis morphology"
    ],
    "gold_answer": "Abnormal male internal genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12153",
    "question": "What is associated with Proptosis?",
    "seeds": [
      "Proptosis"
    ],
    "gold_answer": "Abnormality of globe location",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12154",
    "question": "What is associated with Irregular epiphyses of the 2nd toe?",
    "seeds": [
      "Irregular epiphyses of the 2nd toe"
    ],
    "gold_answer": "Irregular epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12155",
    "question": "What is associated with Babesiosis?",
    "seeds": [
      "Babesiosis"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12156",
    "question": "What is associated with Autoinflammatory disease, systemic, with vasculitis?",
    "seeds": [
      "Autoinflammatory disease, systemic, with vasculitis"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12157",
    "question": "What is associated with Enlarged interhemispheric fissure?",
    "seeds": [
      "Enlarged interhemispheric fissure"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12158",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 30?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 30"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12159",
    "question": "What is associated with Philtrum with midline raphe?",
    "seeds": [
      "Philtrum with midline raphe"
    ],
    "gold_answer": "Abnormality of the philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12160",
    "question": "What is associated with Abnormal circulating insulin concentration?",
    "seeds": [
      "Abnormal circulating insulin concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12161",
    "question": "What is associated with Acromesomelic dysplasia, Grebe type?",
    "seeds": [
      "Acromesomelic dysplasia, Grebe type"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12162",
    "question": "What is associated with Semantic dementia?",
    "seeds": [
      "Semantic dementia"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12163",
    "question": "What is associated with Absent epiphyses of the thumb?",
    "seeds": [
      "Absent epiphyses of the thumb"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12164",
    "question": "What is associated with Exacerbated by phenytoin exposure?",
    "seeds": [
      "Exacerbated by phenytoin exposure"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12165",
    "question": "What is associated with Ganglioside accumulation?",
    "seeds": [
      "Ganglioside accumulation"
    ],
    "gold_answer": "Abnormal glycosphingolipid metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12166",
    "question": "What is associated with Postorgasmic illness syndrome?",
    "seeds": [
      "Postorgasmic illness syndrome"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12167",
    "question": "What phenotype is associated with Generalized epilepsy with febrile seizures plus, type 10?",
    "seeds": [
      "Generalized epilepsy with febrile seizures plus, type 10"
    ],
    "gold_answer": "Autistic behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12168",
    "question": "What is associated with Papilloma?",
    "seeds": [
      "Papilloma"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12169",
    "question": "What is associated with Kerion?",
    "seeds": [
      "Kerion"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12170",
    "question": "What is associated with Decreased circulating complement C5 concentration?",
    "seeds": [
      "Decreased circulating complement C5 concentration"
    ],
    "gold_answer": "Abnormality of complement system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12171",
    "question": "What is associated with Vitreous floaters?",
    "seeds": [
      "Vitreous floaters"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12172",
    "question": "What phenotype is associated with Cornea guttata with anterior polar cataracts?",
    "seeds": [
      "Cornea guttata with anterior polar cataracts"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12173",
    "question": "What is associated with Elbow localization?",
    "seeds": [
      "Elbow localization"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12174",
    "question": "What is associated with Spinocerebellar ataxia 17?",
    "seeds": [
      "Spinocerebellar ataxia 17"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12175",
    "question": "What is associated with Fibrocellular crescent?",
    "seeds": [
      "Fibrocellular crescent"
    ],
    "gold_answer": "Abnormal Bowman space morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12176",
    "question": "What is associated with Toe, misshapen?",
    "seeds": [
      "Toe, misshapen"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12177",
    "question": "What is associated with Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies?",
    "seeds": [
      "Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies"
    ],
    "gold_answer": "Abnormal ureter physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12178",
    "question": "What is associated with Nanophthalmos 4?",
    "seeds": [
      "Nanophthalmos 4"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12179",
    "question": "What phenotype is associated with INCISORS, LONG UPPER CENTRAL?",
    "seeds": [
      "INCISORS, LONG UPPER CENTRAL"
    ],
    "gold_answer": "Macrodontia of permanent maxillary central incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12180",
    "question": "What is associated with Elevated urinary deoxyuridine level?",
    "seeds": [
      "Elevated urinary deoxyuridine level"
    ],
    "gold_answer": "Abnormal urinary pyrimidine level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12181",
    "question": "What is associated with Halo vision?",
    "seeds": [
      "Halo vision"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12182",
    "question": "What is associated with Lipodystrophy, familial partial, type 1?",
    "seeds": [
      "Lipodystrophy, familial partial, type 1"
    ],
    "gold_answer": "Insulin resistance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12183",
    "question": "What phenotype is associated with Blomstrand lethal chondrodysplasia?",
    "seeds": [
      "Blomstrand lethal chondrodysplasia"
    ],
    "gold_answer": "Short nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12184",
    "question": "What is associated with Sclerosis of the middle phalanx of the 3rd finger?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal 3rd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12185",
    "question": "What is associated with DERMATOGLYPHICS--FINGERPRINT PATTERN?",
    "seeds": [
      "DERMATOGLYPHICS--FINGERPRINT PATTERN"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12186",
    "question": "What is associated with Fractured proximal phalanx of digit 2?",
    "seeds": [
      "Fractured proximal phalanx of digit 2"
    ],
    "gold_answer": "Long-bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12187",
    "question": "What is associated with Abnormal morphology of the pelvis musculature?",
    "seeds": [
      "Abnormal morphology of the pelvis musculature"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12188",
    "question": "What is associated with Multiple symmetric lipomatosis?",
    "seeds": [
      "Multiple symmetric lipomatosis"
    ],
    "gold_answer": "Visceromegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12189",
    "question": "What is associated with Reduced radioactive iodine uptake?",
    "seeds": [
      "Reduced radioactive iodine uptake"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12190",
    "question": "What is associated with Tortuous cerebral arteries?",
    "seeds": [
      "Tortuous cerebral arteries"
    ],
    "gold_answer": "Arterial tortuosity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12191",
    "question": "What is associated with Gangliocytoma?",
    "seeds": [
      "Gangliocytoma"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12192",
    "question": "What is associated with Pulsatile mass in extremity?",
    "seeds": [
      "Pulsatile mass in extremity"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12193",
    "question": "What is associated with Anti-GT1a antibody positivity?",
    "seeds": [
      "Anti-GT1a antibody positivity"
    ],
    "gold_answer": "Anti-ganglioside antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12194",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 6?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 6"
    ],
    "gold_answer": "Abnormal posterior cranial fossa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12195",
    "question": "What is associated with Abnormal circulating threonine concentration?",
    "seeds": [
      "Abnormal circulating threonine concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12196",
    "question": "What is associated with Paroxysmal non-kinesigenic dyskinesia?",
    "seeds": [
      "Paroxysmal non-kinesigenic dyskinesia"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12197",
    "question": "What is associated with Ureteral polyp?",
    "seeds": [
      "Ureteral polyp"
    ],
    "gold_answer": "Neoplasm of the ureter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12198",
    "question": "What is associated with Decreased galactosylation of N-linked protein glycosylation?",
    "seeds": [
      "Decreased galactosylation of N-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12199",
    "question": "What is associated with Triangular shaped phalanges of the 4th toe?",
    "seeds": [
      "Triangular shaped phalanges of the 4th toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12200",
    "question": "What is associated with Cone-shaped epiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Cone-shaped epiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the middle phalanx of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12201",
    "question": "What is associated with Abnormality of the epiphysis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Abnormality of the epiphysis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12202",
    "question": "What is associated with Enteric intraneuronal nuclear inclusion bodies?",
    "seeds": [
      "Enteric intraneuronal nuclear inclusion bodies"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12203",
    "question": "What is associated with Normocytic hypoplastic anemia?",
    "seeds": [
      "Normocytic hypoplastic anemia"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12204",
    "question": "What is associated with Renal arteriole intima/media crystal accumulation?",
    "seeds": [
      "Renal arteriole intima/media crystal accumulation"
    ],
    "gold_answer": "Abnormal renal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12205",
    "question": "What is associated with Thyrocerebrorenal syndrome?",
    "seeds": [
      "Thyrocerebrorenal syndrome"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12206",
    "question": "What is associated with Abnormal circulating interleukin 23 concentration?",
    "seeds": [
      "Abnormal circulating interleukin 23 concentration"
    ],
    "gold_answer": "Abnormal circulating interleukin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12207",
    "question": "What is associated with Increased circulating iron concentration?",
    "seeds": [
      "Increased circulating iron concentration"
    ],
    "gold_answer": "Abnormality of iron homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12208",
    "question": "What is associated with Warburg micro syndrome 1?",
    "seeds": [
      "Warburg micro syndrome 1"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebellar vermis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12209",
    "question": "What is associated with Migraine with or without aura, susceptibility to, 6?",
    "seeds": [
      "Migraine with or without aura, susceptibility to, 6"
    ],
    "gold_answer": "Weakness due to upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12210",
    "question": "What is associated with Intellectual disability-short stature-hypertelorism syndrome?",
    "seeds": [
      "Intellectual disability-short stature-hypertelorism syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12211",
    "question": "What is associated with Shawl sign?",
    "seeds": [
      "Shawl sign"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12212",
    "question": "What is associated with Elevated circulating trihydroxycholestanoic acid concentration?",
    "seeds": [
      "Elevated circulating trihydroxycholestanoic acid concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12213",
    "question": "What is associated with Axial muscle stiffness?",
    "seeds": [
      "Axial muscle stiffness"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12214",
    "question": "What is associated with Sporadic Creutzfeldt-Jakob disease?",
    "seeds": [
      "Sporadic Creutzfeldt-Jakob disease"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12215",
    "question": "What phenotype is associated with Mohr syndrome?",
    "seeds": [
      "Mohr syndrome"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12216",
    "question": "What phenotype is associated with Succinyl CoA:3-oxoacid CoA transferase deficiency?",
    "seeds": [
      "Succinyl CoA:3-oxoacid CoA transferase deficiency"
    ],
    "gold_answer": "Episodic ketoacidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12217",
    "question": "What is associated with Abnormality of primary teeth?",
    "seeds": [
      "Abnormality of primary teeth"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12218",
    "question": "What phenotype is associated with Late-infantile/juvenile Krabbe disease?",
    "seeds": [
      "Late-infantile/juvenile Krabbe disease"
    ],
    "gold_answer": "EEG with persistent abnormal rhythmic activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12219",
    "question": "What is associated with EMG: incremental response of compound muscle action potential to repetitive nerve stimulation?",
    "seeds": [
      "EMG: incremental response of compound muscle action potential to repetitive nerve stimulation"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12220",
    "question": "What is associated with Increased glucose-6-phosphate dehydrogenase level in tissue?",
    "seeds": [
      "Increased glucose-6-phosphate dehydrogenase level in tissue"
    ],
    "gold_answer": "Abnormal circulating glucose-6-phosphate dehydrogenase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12221",
    "question": "What is associated with Superior transverse scapular ligament, calcification of, familial?",
    "seeds": [
      "Superior transverse scapular ligament, calcification of, familial"
    ],
    "gold_answer": "Ectopic ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12222",
    "question": "What is associated with Coarse metaphyseal trabecularization?",
    "seeds": [
      "Coarse metaphyseal trabecularization"
    ],
    "gold_answer": "Abnormal metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12223",
    "question": "What is associated with Elevated urinary uroporphyrin level?",
    "seeds": [
      "Elevated urinary uroporphyrin level"
    ],
    "gold_answer": "Abnormal urinary organic compound level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12224",
    "question": "What is associated with Posterior fossa cyst at the fourth ventricle?",
    "seeds": [
      "Posterior fossa cyst at the fourth ventricle"
    ],
    "gold_answer": "Abnormal skull base morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12225",
    "question": "What is associated with Multiple pulmonary cysts?",
    "seeds": [
      "Multiple pulmonary cysts"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12226",
    "question": "What is associated with Craniofacial dystonia?",
    "seeds": [
      "Craniofacial dystonia"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12227",
    "question": "What is associated with MYT1L-related developmental delay-intellectual disability-obesity syndrome?",
    "seeds": [
      "MYT1L-related developmental delay-intellectual disability-obesity syndrome"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12228",
    "question": "What phenotype is associated with Pancreatic cancer?",
    "seeds": [
      "Pancreatic cancer"
    ],
    "gold_answer": "Increased level of L-fucose in urine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12229",
    "question": "What is associated with Urinary tract neoplasm?",
    "seeds": [
      "Urinary tract neoplasm"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12230",
    "question": "What is associated with Impaired renal concentrating ability?",
    "seeds": [
      "Impaired renal concentrating ability"
    ],
    "gold_answer": "Abnormal renal tubular resorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12231",
    "question": "What is associated with Shukla-Vernon syndrome?",
    "seeds": [
      "Shukla-Vernon syndrome"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12232",
    "question": "What is associated with Granular macular appearance?",
    "seeds": [
      "Granular macular appearance"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12233",
    "question": "What is associated with Bifid nasal tip?",
    "seeds": [
      "Bifid nasal tip"
    ],
    "gold_answer": "Abnormal nasal tip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12234",
    "question": "What is associated with Parenchymal consolidation?",
    "seeds": [
      "Parenchymal consolidation"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12235",
    "question": "What phenotype is associated with Cardiomyopathy, dilated, 1Z?",
    "seeds": [
      "Cardiomyopathy, dilated, 1Z"
    ],
    "gold_answer": "Dilated cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12236",
    "question": "What is associated with Abnormal middle ear reflexes?",
    "seeds": [
      "Abnormal middle ear reflexes"
    ],
    "gold_answer": "Functional abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12237",
    "question": "What is associated with Abnormal hand diaphysis morphology?",
    "seeds": [
      "Abnormal hand diaphysis morphology"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12238",
    "question": "What is associated with German syndrome?",
    "seeds": [
      "German syndrome"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12239",
    "question": "What is associated with Tzanck smear with multinucleated giant cells?",
    "seeds": [
      "Tzanck smear with multinucleated giant cells"
    ],
    "gold_answer": "Positive skin infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12240",
    "question": "What is associated with Serpentine fibula?",
    "seeds": [
      "Serpentine fibula"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12241",
    "question": "What is associated with Bilateral basal ganglia lesions?",
    "seeds": [
      "Bilateral basal ganglia lesions"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12242",
    "question": "What is associated with Cone-shaped epiphysis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Cone-shaped epiphysis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Cone-shaped epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12243",
    "question": "What is associated with Macular dystrophy, butterfly-shaped pigmentary, 2?",
    "seeds": [
      "Macular dystrophy, butterfly-shaped pigmentary, 2"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12244",
    "question": "What is associated with Cerebral hemisphere mass lesion?",
    "seeds": [
      "Cerebral hemisphere mass lesion"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12245",
    "question": "What is associated with Developmental and epileptic encephalopathy 121?",
    "seeds": [
      "Developmental and epileptic encephalopathy 121"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12246",
    "question": "What is associated with Abnormality of carpal bone ossification?",
    "seeds": [
      "Abnormality of carpal bone ossification"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12247",
    "question": "What is associated with Pelvic mass?",
    "seeds": [
      "Pelvic mass"
    ],
    "gold_answer": "Abnormal abdomen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12248",
    "question": "What is associated with Abnormal vascular physiology?",
    "seeds": [
      "Abnormal vascular physiology"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12249",
    "question": "What phenotype is associated with Desbuquois dysplasia 2?",
    "seeds": [
      "Desbuquois dysplasia 2"
    ],
    "gold_answer": "Hypodontia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12250",
    "question": "What is associated with Upper limb dysmetria?",
    "seeds": [
      "Upper limb dysmetria"
    ],
    "gold_answer": "Limb dysmetria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12251",
    "question": "What is associated with Short columella?",
    "seeds": [
      "Short columella"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12252",
    "question": "What is associated with Esophageal varix?",
    "seeds": [
      "Esophageal varix"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12253",
    "question": "What is associated with Extension of eyebrows towards upper eyelid?",
    "seeds": [
      "Extension of eyebrows towards upper eyelid"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12254",
    "question": "What phenotype is associated with Hyperinsulinemic hypoglycemia, familial, 2?",
    "seeds": [
      "Hyperinsulinemic hypoglycemia, familial, 2"
    ],
    "gold_answer": "Nesidioblastosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12255",
    "question": "What is associated with Duplication of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Duplication of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Duplication of distal phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12256",
    "question": "What is associated with Type II radial ray deficiency?",
    "seeds": [
      "Type II radial ray deficiency"
    ],
    "gold_answer": "Abnormal morphology of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12257",
    "question": "What phenotype is associated with Cancer-associated retinopathy?",
    "seeds": [
      "Cancer-associated retinopathy"
    ],
    "gold_answer": "Anti-recoverin antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12258",
    "question": "What is associated with Interlobular septal thickening?",
    "seeds": [
      "Interlobular septal thickening"
    ],
    "gold_answer": "Pulmonary interstitial high-resolution computed tomography abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12259",
    "question": "What is associated with Chest pain?",
    "seeds": [
      "Chest pain"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12260",
    "question": "What is associated with Abnormal tissue alpha-N-acetylglucosaminidase activity?",
    "seeds": [
      "Abnormal tissue alpha-N-acetylglucosaminidase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12261",
    "question": "What phenotype is associated with Craniosynostosis, Herrmann-Opitz type?",
    "seeds": [
      "Craniosynostosis, Herrmann-Opitz type"
    ],
    "gold_answer": "Atresia of the external auditory canal",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12262",
    "question": "What is associated with Annular pancreas?",
    "seeds": [
      "Annular pancreas"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12263",
    "question": "What is associated with Protuberances at ends of long bones?",
    "seeds": [
      "Protuberances at ends of long bones"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12264",
    "question": "What is associated with Bipolar affective disorder?",
    "seeds": [
      "Bipolar affective disorder"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12265",
    "question": "What is associated with Decerebrate rigidity?",
    "seeds": [
      "Decerebrate rigidity"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12266",
    "question": "What is associated with 2-oxoadipic aciduria?",
    "seeds": [
      "2-oxoadipic aciduria"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12267",
    "question": "What is associated with Fuchs endothelial corneal dystrophy?",
    "seeds": [
      "Fuchs endothelial corneal dystrophy"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12268",
    "question": "What is associated with Progressive familial intrahepatic cholestasis type 1?",
    "seeds": [
      "Progressive familial intrahepatic cholestasis type 1"
    ],
    "gold_answer": "ATP8B1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12269",
    "question": "What is associated with Knuckle pads?",
    "seeds": [
      "Knuckle pads"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12270",
    "question": "What is associated with Developmental and epileptic encephalopathy 65?",
    "seeds": [
      "Developmental and epileptic encephalopathy 65"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12271",
    "question": "What is associated with Severe expressive language delay?",
    "seeds": [
      "Severe expressive language delay"
    ],
    "gold_answer": "Expressive language delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12272",
    "question": "What phenotype is associated with Polydactyly, postaxial, type A10?",
    "seeds": [
      "Polydactyly, postaxial, type A10"
    ],
    "gold_answer": "Postaxial foot polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12273",
    "question": "What is associated with Valgus instability of the elbow?",
    "seeds": [
      "Valgus instability of the elbow"
    ],
    "gold_answer": "Elbow instability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12274",
    "question": "What is associated with Dermoids of cornea?",
    "seeds": [
      "Dermoids of cornea"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12275",
    "question": "What phenotype is associated with Developmental delay-language impairment-dopa responsive dystonia-parkinsonism syndrome due to 2q24 microdeletion?",
    "seeds": [
      "Developmental delay-language impairment-dopa responsive dystonia-parkinsonism syndrome due to 2q24 microdeletion"
    ],
    "gold_answer": "Short neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12276",
    "question": "What is associated with Calcific stippling?",
    "seeds": [
      "Calcific stippling"
    ],
    "gold_answer": "Ectopic calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12277",
    "question": "What phenotype is associated with Cronkhite-Canada syndrome?",
    "seeds": [
      "Cronkhite-Canada syndrome"
    ],
    "gold_answer": "Anorexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12278",
    "question": "What phenotype is associated with Mitochondrial DNA depletion syndrome 18?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 18"
    ],
    "gold_answer": "Elevated urinary quinolinic acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12279",
    "question": "What is associated with Polycoria?",
    "seeds": [
      "Polycoria"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12280",
    "question": "What is associated with Abnormal radioactive iodine uptake test result?",
    "seeds": [
      "Abnormal radioactive iodine uptake test result"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12281",
    "question": "What is associated with C1-C2 vertebral abnormality?",
    "seeds": [
      "C1-C2 vertebral abnormality"
    ],
    "gold_answer": "Abnormality of the cervical spine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12282",
    "question": "What is associated with Gottron sign?",
    "seeds": [
      "Gottron sign"
    ],
    "gold_answer": "Macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12283",
    "question": "What is associated with Elevated CSF alpha-ketoglutarate concentration?",
    "seeds": [
      "Elevated CSF alpha-ketoglutarate concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12284",
    "question": "What is associated with Fibular dimelia-diplopodia syndrome?",
    "seeds": [
      "Fibular dimelia-diplopodia syndrome"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12285",
    "question": "What is associated with Hypoaldosteronism, congenital, due to CMO II deficiency?",
    "seeds": [
      "Hypoaldosteronism, congenital, due to CMO II deficiency"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12286",
    "question": "What is associated with Abnormal cutaneous collagen fibril morphology?",
    "seeds": [
      "Abnormal cutaneous collagen fibril morphology"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12287",
    "question": "What is associated with BOR syndrome?",
    "seeds": [
      "BOR syndrome"
    ],
    "gold_answer": "Dilatation of the renal pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12288",
    "question": "What is associated with Cor triatriatum sinister?",
    "seeds": [
      "Cor triatriatum sinister"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12289",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 23?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 23"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12290",
    "question": "What is associated with Colorectal polyposis?",
    "seeds": [
      "Colorectal polyposis"
    ],
    "gold_answer": "Neoplasm of the rectum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12291",
    "question": "What phenotype is associated with Oculo-auriculo-vertebral spectrum?",
    "seeds": [
      "Oculo-auriculo-vertebral spectrum"
    ],
    "gold_answer": "Choanal atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12292",
    "question": "What is associated with AMED syndrome, digenic?",
    "seeds": [
      "AMED syndrome, digenic"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12293",
    "question": "What is associated with Bladder stones?",
    "seeds": [
      "Bladder stones"
    ],
    "gold_answer": "Abnormal bladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12294",
    "question": "What is associated with Craniofacial dysostosis?",
    "seeds": [
      "Craniofacial dysostosis"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12295",
    "question": "What is associated with 1q21.1 microdeletion syndrome?",
    "seeds": [
      "1q21.1 microdeletion syndrome"
    ],
    "gold_answer": "Hyperactivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12296",
    "question": "What is associated with Oligoarticular juvenile idiopathic arthritis?",
    "seeds": [
      "Oligoarticular juvenile idiopathic arthritis"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12297",
    "question": "What phenotype is associated with Sarcoidosis?",
    "seeds": [
      "Sarcoidosis"
    ],
    "gold_answer": "Erythema nodosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12298",
    "question": "What is associated with Enlarged fossa interpeduncularis?",
    "seeds": [
      "Enlarged fossa interpeduncularis"
    ],
    "gold_answer": "Ventriculomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12299",
    "question": "What phenotype is associated with Nail disorder, nonsyndromic congenital, 1?",
    "seeds": [
      "Nail disorder, nonsyndromic congenital, 1"
    ],
    "gold_answer": "Onychogryphosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12300",
    "question": "What is associated with Irregular myelin loops?",
    "seeds": [
      "Irregular myelin loops"
    ],
    "gold_answer": "Peripheral hypermyelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12301",
    "question": "What is associated with Hepatic vascular malformations?",
    "seeds": [
      "Hepatic vascular malformations"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12302",
    "question": "What is associated with Disciform macular scar?",
    "seeds": [
      "Disciform macular scar"
    ],
    "gold_answer": "Retinal atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12303",
    "question": "What is associated with Retinal dots?",
    "seeds": [
      "Retinal dots"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12304",
    "question": "What is associated with Creatine phosphokinase, elevated serum?",
    "seeds": [
      "Creatine phosphokinase, elevated serum"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12305",
    "question": "What phenotype is associated with Glaucoma 1, open angle, P?",
    "seeds": [
      "Glaucoma 1, open angle, P"
    ],
    "gold_answer": "Increased cup-to-disc ratio",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12306",
    "question": "What is associated with Coronary artery dissection?",
    "seeds": [
      "Coronary artery dissection"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12307",
    "question": "What phenotype is associated with Maturity-onset diabetes of the young, type 12?",
    "seeds": [
      "Maturity-onset diabetes of the young, type 12"
    ],
    "gold_answer": "Transient neonatal diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12308",
    "question": "What is associated with Broad proximal phalanx of the thumb?",
    "seeds": [
      "Broad proximal phalanx of the thumb"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12309",
    "question": "What is associated with Neuhauser syndrome?",
    "seeds": [
      "Neuhauser syndrome"
    ],
    "gold_answer": "Abnormal soft palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12310",
    "question": "What is associated with Nasopharyngeal carcinoma?",
    "seeds": [
      "Nasopharyngeal carcinoma"
    ],
    "gold_answer": "NFKBIA",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12311",
    "question": "What phenotype is associated with Atypical Gaucher disease due to saposin C deficiency?",
    "seeds": [
      "Atypical Gaucher disease due to saposin C deficiency"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12312",
    "question": "What phenotype is associated with Leber congenital amaurosis 4?",
    "seeds": [
      "Leber congenital amaurosis 4"
    ],
    "gold_answer": "Nyctalopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12313",
    "question": "What is associated with Intellectual disability, Buenos-Aires type?",
    "seeds": [
      "Intellectual disability, Buenos-Aires type"
    ],
    "gold_answer": "Sensory hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12314",
    "question": "What is associated with Increased hepatic echogenicity?",
    "seeds": [
      "Increased hepatic echogenicity"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12315",
    "question": "What is associated with Decreased circulating antimullerian hormone circulation?",
    "seeds": [
      "Decreased circulating antimullerian hormone circulation"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12316",
    "question": "What is associated with Hypermanganesemia with dystonia 2?",
    "seeds": [
      "Hypermanganesemia with dystonia 2"
    ],
    "gold_answer": "Abnormal morphology of the musculature of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12317",
    "question": "What is associated with Single-lobed right lung?",
    "seeds": [
      "Single-lobed right lung"
    ],
    "gold_answer": "Abnormal lung lobation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12318",
    "question": "What is associated with Osteoarthritis susceptibility 1?",
    "seeds": [
      "Osteoarthritis susceptibility 1"
    ],
    "gold_answer": "Arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12319",
    "question": "What is associated with Neurodevelopmental disorder with impaired language and ataxia and with or without seizures?",
    "seeds": [
      "Neurodevelopmental disorder with impaired language and ataxia and with or without seizures"
    ],
    "gold_answer": "Unusual infection by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12320",
    "question": "What is associated with Anti-thyroid antibody positivity?",
    "seeds": [
      "Anti-thyroid antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12321",
    "question": "What is associated with Myopia 21, autosomal dominant?",
    "seeds": [
      "Myopia 21, autosomal dominant"
    ],
    "gold_answer": "Abnormality of refraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12322",
    "question": "What phenotype is associated with Polyhydramnios-megalencephaly-symptomatic epilepsy syndrome?",
    "seeds": [
      "Polyhydramnios-megalencephaly-symptomatic epilepsy syndrome"
    ],
    "gold_answer": "Absent speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12323",
    "question": "What is associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome 2?",
    "seeds": [
      "Megacystis-microcolon-intestinal hypoperistalsis syndrome 2"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12324",
    "question": "What is associated with Acanthoma?",
    "seeds": [
      "Acanthoma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12325",
    "question": "What phenotype is associated with Lethal Kniest-like dysplasia?",
    "seeds": [
      "Lethal Kniest-like dysplasia"
    ],
    "gold_answer": "Severe short-limb dwarfism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12326",
    "question": "What is associated with Mosaic monosomy X syndrome?",
    "seeds": [
      "Mosaic monosomy X syndrome"
    ],
    "gold_answer": "Fetal ultrasound soft marker",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12327",
    "question": "What is associated with Reduced circulating lipoprotein(a) concentration?",
    "seeds": [
      "Reduced circulating lipoprotein(a) concentration"
    ],
    "gold_answer": "Abnormality of lipoprotein cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12328",
    "question": "What is associated with Abnormal neoplastic cell morphology?",
    "seeds": [
      "Abnormal neoplastic cell morphology"
    ],
    "gold_answer": "Histopathological abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12329",
    "question": "What is associated with Developmental and epileptic encephalopathy 120?",
    "seeds": [
      "Developmental and epileptic encephalopathy 120"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12330",
    "question": "What is associated with Nemaline myopathy 3?",
    "seeds": [
      "Nemaline myopathy 3"
    ],
    "gold_answer": "Flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12331",
    "question": "What is associated with Blood group O?",
    "seeds": [
      "Blood group O"
    ],
    "gold_answer": "Blood group",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12332",
    "question": "What phenotype is associated with Papillon-Lefèvre syndrome?",
    "seeds": [
      "Papillon-Lefèvre syndrome"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12333",
    "question": "What is associated with Osteolytic defects of the phalanges of the 2nd finger?",
    "seeds": [
      "Osteolytic defects of the phalanges of the 2nd finger"
    ],
    "gold_answer": "Osteolytic defects of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12334",
    "question": "What phenotype is associated with Lymphatic malformation 8?",
    "seeds": [
      "Lymphatic malformation 8"
    ],
    "gold_answer": "Polyhydramnios",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12335",
    "question": "What is associated with Elevated circulating deoxyuridine concentration?",
    "seeds": [
      "Elevated circulating deoxyuridine concentration"
    ],
    "gold_answer": "Abnormal circulating nucleobase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12336",
    "question": "What phenotype is associated with Ataxia-oculomotor apraxia 4?",
    "seeds": [
      "Ataxia-oculomotor apraxia 4"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the brainstem",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12337",
    "question": "What phenotype is associated with Cutis laxa, autosomal dominant 2?",
    "seeds": [
      "Cutis laxa, autosomal dominant 2"
    ],
    "gold_answer": "Mitral regurgitation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12338",
    "question": "What is associated with Beaded bile ducts?",
    "seeds": [
      "Beaded bile ducts"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12339",
    "question": "What is associated with Fixed elbow flexion?",
    "seeds": [
      "Fixed elbow flexion"
    ],
    "gold_answer": "Abnormal elbow physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12340",
    "question": "What is associated with Spastic tetraplegia?",
    "seeds": [
      "Spastic tetraplegia"
    ],
    "gold_answer": "Appendicular spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12341",
    "question": "What is associated with Delayed onset bleeding?",
    "seeds": [
      "Delayed onset bleeding"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12342",
    "question": "What is associated with Epidermolysis bullosa simplex 2B, generalized intermediate?",
    "seeds": [
      "Epidermolysis bullosa simplex 2B, generalized intermediate"
    ],
    "gold_answer": "Abnormality of the plantar skin of foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12343",
    "question": "What is associated with Leprosy, susceptibility to?",
    "seeds": [
      "Leprosy, susceptibility to"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12344",
    "question": "What is associated with Hypoplastic dermoepidermal hemidesmosomes?",
    "seeds": [
      "Hypoplastic dermoepidermal hemidesmosomes"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12345",
    "question": "What is associated with Neurocytic rosette?",
    "seeds": [
      "Neurocytic rosette"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12346",
    "question": "What is associated with Myasthenic syndrome, congenital, 2C, associated with acetylcholine receptor deficiency?",
    "seeds": [
      "Myasthenic syndrome, congenital, 2C, associated with acetylcholine receptor deficiency"
    ],
    "gold_answer": "EMG: impaired neuromuscular transmission",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12347",
    "question": "What is associated with Medially sloping radial metaphysis?",
    "seeds": [
      "Medially sloping radial metaphysis"
    ],
    "gold_answer": "Abnormal radial metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12348",
    "question": "What is associated with Fish odor?",
    "seeds": [
      "Fish odor"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12349",
    "question": "What is associated with Joubert syndrome 14?",
    "seeds": [
      "Joubert syndrome 14"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12350",
    "question": "What phenotype is associated with Intrauterine growth retardation with increased mitomycin C sensitivity?",
    "seeds": [
      "Intrauterine growth retardation with increased mitomycin C sensitivity"
    ],
    "gold_answer": "Postnatal growth retardation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12351",
    "question": "What phenotype is associated with B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome?",
    "seeds": [
      "B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome"
    ],
    "gold_answer": "Kyphoscoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12352",
    "question": "What is associated with Neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia?",
    "seeds": [
      "Neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12353",
    "question": "What is associated with Gordon reflex?",
    "seeds": [
      "Gordon reflex"
    ],
    "gold_answer": "Abnormal spinal cord physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12354",
    "question": "What is associated with Osteolytic defects of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Osteolytic defects of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Osteolytic defects of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12355",
    "question": "What phenotype is associated with Neuronopathy, distal hereditary motor, type IIC?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, type IIC"
    ],
    "gold_answer": "Hand muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12356",
    "question": "What is associated with Reduced circulating fibroblast growth factor 23 concentration?",
    "seeds": [
      "Reduced circulating fibroblast growth factor 23 concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12357",
    "question": "What is associated with Cone-Rod dystrophy 2?",
    "seeds": [
      "Cone-Rod dystrophy 2"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12358",
    "question": "What is associated with Ovarian hyperstimulation syndrome?",
    "seeds": [
      "Ovarian hyperstimulation syndrome"
    ],
    "gold_answer": "Increased circulating androgen concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12359",
    "question": "What is associated with Myopia 9?",
    "seeds": [
      "Myopia 9"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12360",
    "question": "What is associated with Spastic paraplegia-severe developmental delay-epilepsy syndrome?",
    "seeds": [
      "Spastic paraplegia-severe developmental delay-epilepsy syndrome"
    ],
    "gold_answer": "Abnormal peripheral nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12361",
    "question": "What is associated with Uhl's anomaly?",
    "seeds": [
      "Uhl's anomaly"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12362",
    "question": "What is associated with Increased circulating androgen concentration?",
    "seeds": [
      "Increased circulating androgen concentration"
    ],
    "gold_answer": "Abnormal circulating androgen level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12363",
    "question": "What is associated with Angulated forearm bones?",
    "seeds": [
      "Angulated forearm bones"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12364",
    "question": "What is associated with X-linked Charcot-Marie-Tooth disease type 5?",
    "seeds": [
      "X-linked Charcot-Marie-Tooth disease type 5"
    ],
    "gold_answer": "Abnormal cognitive process",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12365",
    "question": "What is associated with Polydactyly, postaxial, type A7?",
    "seeds": [
      "Polydactyly, postaxial, type A7"
    ],
    "gold_answer": "Duplication involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12366",
    "question": "What is associated with Reduced circulating aspartate aminotransferase concentration?",
    "seeds": [
      "Reduced circulating aspartate aminotransferase concentration"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12367",
    "question": "What phenotype is associated with Sternal cleft?",
    "seeds": [
      "Sternal cleft"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12368",
    "question": "What is associated with Arrhythmia?",
    "seeds": [
      "Arrhythmia"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12369",
    "question": "What is associated with Increased CSF ribitol concentration?",
    "seeds": [
      "Increased CSF ribitol concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12370",
    "question": "What is associated with Serpentine skin location?",
    "seeds": [
      "Serpentine skin location"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12371",
    "question": "What is associated with Ulnar translocation of the carpus?",
    "seeds": [
      "Ulnar translocation of the carpus"
    ],
    "gold_answer": "Abnormality of the wrist",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12372",
    "question": "What is associated with Aplasia/Hypoplasia of the frontal sinuses?",
    "seeds": [
      "Aplasia/Hypoplasia of the frontal sinuses"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the sinuses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12373",
    "question": "What is associated with Renal interstitial inflammation?",
    "seeds": [
      "Renal interstitial inflammation"
    ],
    "gold_answer": "Abnormal renal interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12374",
    "question": "What is associated with Hypophosphatemic rickets, X-linked dominant?",
    "seeds": [
      "Hypophosphatemic rickets, X-linked dominant"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12375",
    "question": "What is associated with Latent myopia?",
    "seeds": [
      "Latent myopia"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12376",
    "question": "What is associated with Cerebellar gliosis?",
    "seeds": [
      "Cerebellar gliosis"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12377",
    "question": "What is associated with Dysphasia, familial developmental?",
    "seeds": [
      "Dysphasia, familial developmental"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12378",
    "question": "What is associated with Anti-centromere protein A antibody positivity?",
    "seeds": [
      "Anti-centromere protein A antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12379",
    "question": "What is associated with Greater auricular nerve thickening?",
    "seeds": [
      "Greater auricular nerve thickening"
    ],
    "gold_answer": "Abnormal peripheral nerve morphology by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12380",
    "question": "What is associated with Tapered finger?",
    "seeds": [
      "Tapered finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12381",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2R?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2R"
    ],
    "gold_answer": "Abnormal tracheal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12382",
    "question": "What is associated with Abnormal lower limb epiphysis morphology?",
    "seeds": [
      "Abnormal lower limb epiphysis morphology"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12383",
    "question": "What is associated with Chondritis of pinna?",
    "seeds": [
      "Chondritis of pinna"
    ],
    "gold_answer": "Abnormal cartilage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12384",
    "question": "What is associated with Foveal photoreceptor outer segment loss on macular OCT?",
    "seeds": [
      "Foveal photoreceptor outer segment loss on macular OCT"
    ],
    "gold_answer": "Abnormal foveal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12385",
    "question": "What is associated with Focal segmental glomerulosclerosis?",
    "seeds": [
      "Focal segmental glomerulosclerosis"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12386",
    "question": "What is associated with Increased total bilirubin?",
    "seeds": [
      "Increased total bilirubin"
    ],
    "gold_answer": "Abnormal circulating bilirubin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12387",
    "question": "What is associated with Glycogen storage disease due to muscle glycogen phosphorylase deficiency?",
    "seeds": [
      "Glycogen storage disease due to muscle glycogen phosphorylase deficiency"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12388",
    "question": "What is associated with Elevated circulating trihydroxycholestanoic acid concentration?",
    "seeds": [
      "Elevated circulating trihydroxycholestanoic acid concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12389",
    "question": "What is associated with Social disinhibition?",
    "seeds": [
      "Social disinhibition"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12390",
    "question": "What is associated with Dysplasia of the superior cerebellar vermis?",
    "seeds": [
      "Dysplasia of the superior cerebellar vermis"
    ],
    "gold_answer": "Abnormal cerebellar vermis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12391",
    "question": "What is associated with Deformed tarsal bones?",
    "seeds": [
      "Deformed tarsal bones"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12392",
    "question": "What is associated with Sacral segmentation defect?",
    "seeds": [
      "Sacral segmentation defect"
    ],
    "gold_answer": "Vertebral segmentation defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12393",
    "question": "What is associated with Cone-shaped epiphyses of the hallux?",
    "seeds": [
      "Cone-shaped epiphyses of the hallux"
    ],
    "gold_answer": "Abnormality of the epiphyses of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12394",
    "question": "What is associated with Freckles in sun-exposed areas?",
    "seeds": [
      "Freckles in sun-exposed areas"
    ],
    "gold_answer": "Hyperpigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12395",
    "question": "What is associated with Pseudovaginal perineoscrotal hypospadias?",
    "seeds": [
      "Pseudovaginal perineoscrotal hypospadias"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12396",
    "question": "What is associated with Poor hand-eye coordination?",
    "seeds": [
      "Poor hand-eye coordination"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12397",
    "question": "What is associated with Nummular keratitis?",
    "seeds": [
      "Nummular keratitis"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12398",
    "question": "What is associated with Abnormal light-adapted electroretinogram?",
    "seeds": [
      "Abnormal light-adapted electroretinogram"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12399",
    "question": "What is associated with Anti-soluble liver antigen/liver pancreas antibody positivity?",
    "seeds": [
      "Anti-soluble liver antigen/liver pancreas antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12400",
    "question": "What is associated with Cerebral cortical atrophy?",
    "seeds": [
      "Cerebral cortical atrophy"
    ],
    "gold_answer": "Brain atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12401",
    "question": "What is associated with Second metatarsal posteriorly placed?",
    "seeds": [
      "Second metatarsal posteriorly placed"
    ],
    "gold_answer": "Abnormal metatarsal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12402",
    "question": "What is associated with Word salad?",
    "seeds": [
      "Word salad"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12403",
    "question": "What is associated with Forceps delivery?",
    "seeds": [
      "Forceps delivery"
    ],
    "gold_answer": "Abnormal delivery",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12404",
    "question": "What is associated with Abnormal circulating dicarboxylic acid concentration?",
    "seeds": [
      "Abnormal circulating dicarboxylic acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12405",
    "question": "What is associated with Mesoaxial hand polydactyly?",
    "seeds": [
      "Mesoaxial hand polydactyly"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12406",
    "question": "What is associated with Double eyebrow?",
    "seeds": [
      "Double eyebrow"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12407",
    "question": "What is associated with Constitutional symptom?",
    "seeds": [
      "Constitutional symptom"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12408",
    "question": "What is associated with Otofaciocervical syndrome?",
    "seeds": [
      "Otofaciocervical syndrome"
    ],
    "gold_answer": "Abnormal cochlea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12409",
    "question": "What is associated with Oguchi disease 1?",
    "seeds": [
      "Oguchi disease 1"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12410",
    "question": "What is associated with EEG with diffuse acceleration?",
    "seeds": [
      "EEG with diffuse acceleration"
    ],
    "gold_answer": "Abnormal nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12411",
    "question": "What is associated with Duplicated tragus?",
    "seeds": [
      "Duplicated tragus"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12412",
    "question": "What is associated with Microdontia of primary teeth?",
    "seeds": [
      "Microdontia of primary teeth"
    ],
    "gold_answer": "Abnormality of primary teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12413",
    "question": "What is associated with GM2-gangliosidosis, AB variant?",
    "seeds": [
      "GM2-gangliosidosis, AB variant"
    ],
    "gold_answer": "Long-tract sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12414",
    "question": "What is associated with Lack of gonadotropin-releasing hormone pulsatility?",
    "seeds": [
      "Lack of gonadotropin-releasing hormone pulsatility"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12415",
    "question": "What is associated with Ciliary dyskinesia, primary, 54?",
    "seeds": [
      "Ciliary dyskinesia, primary, 54"
    ],
    "gold_answer": "Recurrent respiratory infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12416",
    "question": "What is associated with Elevated circulating dodecenoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating dodecenoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12417",
    "question": "What phenotype is associated with Ankylosing vertebral hyperostosis with tylosis?",
    "seeds": [
      "Ankylosing vertebral hyperostosis with tylosis"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12418",
    "question": "What phenotype is associated with Hemoglobin C-beta-thalassemia syndrome?",
    "seeds": [
      "Hemoglobin C-beta-thalassemia syndrome"
    ],
    "gold_answer": "Abnormal hemoglobin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12419",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 39?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 39"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12420",
    "question": "What is associated with Wolfram-Like syndrome, autosomal dominant?",
    "seeds": [
      "Wolfram-Like syndrome, autosomal dominant"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12421",
    "question": "What is associated with Symmetric T2-signal increase with T1-signal decrease in the putamen?",
    "seeds": [
      "Symmetric T2-signal increase with T1-signal decrease in the putamen"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12422",
    "question": "What is associated with Blue sclerae?",
    "seeds": [
      "Blue sclerae"
    ],
    "gold_answer": "Abnormal sclera morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12423",
    "question": "What is associated with Curved distal phalanx of the 5th finger?",
    "seeds": [
      "Curved distal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12424",
    "question": "What phenotype is associated with 7p22.1 microduplication syndrome?",
    "seeds": [
      "7p22.1 microduplication syndrome"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12425",
    "question": "What is associated with Reduced terminal:vellus ratio?",
    "seeds": [
      "Reduced terminal:vellus ratio"
    ],
    "gold_answer": "Abnormal terminal:vellus ratio",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12426",
    "question": "What phenotype is associated with Acute adrenal insufficiency?",
    "seeds": [
      "Acute adrenal insufficiency"
    ],
    "gold_answer": "Hyperkalemic metabolic acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12427",
    "question": "What is associated with Fractured facial bone?",
    "seeds": [
      "Fractured facial bone"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12428",
    "question": "What is associated with Fractured distal phalanx of manual digit 5?",
    "seeds": [
      "Fractured distal phalanx of manual digit 5"
    ],
    "gold_answer": "Abnormal 5th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12429",
    "question": "What is associated with Hypotrichosis 6?",
    "seeds": [
      "Hypotrichosis 6"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12430",
    "question": "What is associated with Anterior bowing of long bones?",
    "seeds": [
      "Anterior bowing of long bones"
    ],
    "gold_answer": "Abnormal diaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12431",
    "question": "What phenotype is associated with Renal tubular acidosis, distal, autosomal dominant?",
    "seeds": [
      "Renal tubular acidosis, distal, autosomal dominant"
    ],
    "gold_answer": "Diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12432",
    "question": "What is associated with Elevated circulating 4-hydroxyphenylacetic acid concentration?",
    "seeds": [
      "Elevated circulating 4-hydroxyphenylacetic acid concentration"
    ],
    "gold_answer": "Abnormal circulating monocarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12433",
    "question": "What is associated with Trichorhinophalangeal syndrome type 1?",
    "seeds": [
      "Trichorhinophalangeal syndrome type 1"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12434",
    "question": "What is associated with Focal cortical dysplasia type IIIb?",
    "seeds": [
      "Focal cortical dysplasia type IIIb"
    ],
    "gold_answer": "Focal cortical dysplasia type III",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12435",
    "question": "What is associated with Cortical dysplasia?",
    "seeds": [
      "Cortical dysplasia"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12436",
    "question": "What is associated with Elevated urine keto acid level?",
    "seeds": [
      "Elevated urine keto acid level"
    ],
    "gold_answer": "Organic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12437",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 60?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 60"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12438",
    "question": "What is associated with Renal steatosis?",
    "seeds": [
      "Renal steatosis"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12439",
    "question": "What is associated with Anti-factor XIII antibody positivity?",
    "seeds": [
      "Anti-factor XIII antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12440",
    "question": "What is associated with Laryngeal stenosis?",
    "seeds": [
      "Laryngeal stenosis"
    ],
    "gold_answer": "Abnormality of the upper respiratory tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12441",
    "question": "What phenotype is associated with Corneal endothelial dystrophy and perceptive deafness?",
    "seeds": [
      "Corneal endothelial dystrophy and perceptive deafness"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12442",
    "question": "What is associated with Oblique fracture?",
    "seeds": [
      "Oblique fracture"
    ],
    "gold_answer": "Fracture type",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12443",
    "question": "What is associated with SLC40A1-related hemochromatosis?",
    "seeds": [
      "SLC40A1-related hemochromatosis"
    ],
    "gold_answer": "SLC40A1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_train_12444",
    "question": "What phenotype is associated with Gallbladder disease 1?",
    "seeds": [
      "Gallbladder disease 1"
    ],
    "gold_answer": "Elevated circulating hepatic transaminase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12445",
    "question": "What is associated with Abnormality of the anterior pituitary?",
    "seeds": [
      "Abnormality of the anterior pituitary"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12446",
    "question": "What is associated with Sclerosis of proximal phalanx of toe?",
    "seeds": [
      "Sclerosis of proximal phalanx of toe"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12447",
    "question": "What is associated with Focal aware sensory seizure with auditory features?",
    "seeds": [
      "Focal aware sensory seizure with auditory features"
    ],
    "gold_answer": "Epileptic aura",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12448",
    "question": "What is associated with Persistent head lag?",
    "seeds": [
      "Persistent head lag"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12449",
    "question": "What is associated with Edema of the dorsum of feet?",
    "seeds": [
      "Edema of the dorsum of feet"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12450",
    "question": "What is associated with Neurodevelopmental disorder with progressive spasticity and brain abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with progressive spasticity and brain abnormalities"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12451",
    "question": "What is associated with Fragmentation of the epiphyses of the 5th toe?",
    "seeds": [
      "Fragmentation of the epiphyses of the 5th toe"
    ],
    "gold_answer": "Abnormal fifth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12452",
    "question": "What is associated with Short proximal phalanx of the 5th toe?",
    "seeds": [
      "Short proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Short phalanx of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12453",
    "question": "What is associated with Recurrent deep vein thrombosis?",
    "seeds": [
      "Recurrent deep vein thrombosis"
    ],
    "gold_answer": "Venous thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12454",
    "question": "What is associated with Tessier number 8 facial cleft?",
    "seeds": [
      "Tessier number 8 facial cleft"
    ],
    "gold_answer": "Transverse facial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12455",
    "question": "What is associated with Hyperoxaluria, primary, type I?",
    "seeds": [
      "Hyperoxaluria, primary, type I"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12456",
    "question": "What is associated with Nonspecific interstitial pneumonia?",
    "seeds": [
      "Nonspecific interstitial pneumonia"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12457",
    "question": "What is associated with Epilepsy, early-onset, vitamin b6-dependent?",
    "seeds": [
      "Epilepsy, early-onset, vitamin b6-dependent"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12458",
    "question": "What is associated with Vaginal mucosal ulceration?",
    "seeds": [
      "Vaginal mucosal ulceration"
    ],
    "gold_answer": "Abnormal internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12459",
    "question": "What is associated with Abnormality of the musculature of the upper limbs?",
    "seeds": [
      "Abnormality of the musculature of the upper limbs"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12460",
    "question": "What is associated with Abnormality of mental function?",
    "seeds": [
      "Abnormality of mental function"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12461",
    "question": "What is associated with Intracranial cystic lesion?",
    "seeds": [
      "Intracranial cystic lesion"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12462",
    "question": "What phenotype is associated with Absent radius-anogenital anomalies syndrome?",
    "seeds": [
      "Absent radius-anogenital anomalies syndrome"
    ],
    "gold_answer": "Perineal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12463",
    "question": "What is associated with Cholestasis, progressive familial intrahepatic, 3?",
    "seeds": [
      "Cholestasis, progressive familial intrahepatic, 3"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12464",
    "question": "What is associated with Thin spermatozoon midpiece?",
    "seeds": [
      "Thin spermatozoon midpiece"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12465",
    "question": "What is associated with Abnormality of the chin?",
    "seeds": [
      "Abnormality of the chin"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12466",
    "question": "What is associated with Failure of phenylephrine to induce blanching of eye redness?",
    "seeds": [
      "Failure of phenylephrine to induce blanching of eye redness"
    ],
    "gold_answer": "Inflammatory abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12467",
    "question": "What is associated with Bullet-shaped phalanges of the 2nd finger?",
    "seeds": [
      "Bullet-shaped phalanges of the 2nd finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12468",
    "question": "What is associated with Mietens-Weber syndrome?",
    "seeds": [
      "Mietens-Weber syndrome"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12469",
    "question": "What is associated with Aplasia of the inner ear?",
    "seeds": [
      "Aplasia of the inner ear"
    ],
    "gold_answer": "Abnormal inner ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12470",
    "question": "What is associated with Yellow nail syndrome?",
    "seeds": [
      "Yellow nail syndrome"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12471",
    "question": "What is associated with Abnormal muscle fiber alpha sarcoglycan?",
    "seeds": [
      "Abnormal muscle fiber alpha sarcoglycan"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12472",
    "question": "What is associated with Macrocytic dyserythropoietic anemia?",
    "seeds": [
      "Macrocytic dyserythropoietic anemia"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12473",
    "question": "What is associated with Skin dimple?",
    "seeds": [
      "Skin dimple"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12474",
    "question": "What is associated with Congenital ichthyosis-microcephalus-tetraplegia syndrome?",
    "seeds": [
      "Congenital ichthyosis-microcephalus-tetraplegia syndrome"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12475",
    "question": "What phenotype is associated with CYSTATHIONINURIA?",
    "seeds": [
      "CYSTATHIONINURIA"
    ],
    "gold_answer": "Cystathioninuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12476",
    "question": "What phenotype is associated with Non-distal deletion 10q syndrome?",
    "seeds": [
      "Non-distal deletion 10q syndrome"
    ],
    "gold_answer": "Upslanted palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12477",
    "question": "What is associated with Mediastinal teratoma?",
    "seeds": [
      "Mediastinal teratoma"
    ],
    "gold_answer": "Embryonal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12478",
    "question": "What is associated with Retrobulbar optic neuritis?",
    "seeds": [
      "Retrobulbar optic neuritis"
    ],
    "gold_answer": "Optic neuritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12479",
    "question": "What is associated with Wind-swept deformity of the knees?",
    "seeds": [
      "Wind-swept deformity of the knees"
    ],
    "gold_answer": "Bowing of the legs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12480",
    "question": "What is associated with Intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome?",
    "seeds": [
      "Intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12481",
    "question": "What is associated with Mannose 6-phosphate receptor recognition defect, Lebanese type?",
    "seeds": [
      "Mannose 6-phosphate receptor recognition defect, Lebanese type"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12482",
    "question": "What is associated with Square face?",
    "seeds": [
      "Square face"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12483",
    "question": "What is associated with Presyncope?",
    "seeds": [
      "Presyncope"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12484",
    "question": "What is associated with Long hairstyle?",
    "seeds": [
      "Long hairstyle"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12485",
    "question": "What is associated with CIDEC-related familial partial lipodystrophy?",
    "seeds": [
      "CIDEC-related familial partial lipodystrophy"
    ],
    "gold_answer": "Abnormal glucose homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12486",
    "question": "What phenotype is associated with Acrofrontofacionasal dysostosis 1?",
    "seeds": [
      "Acrofrontofacionasal dysostosis 1"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12487",
    "question": "What is associated with Vascular malformation of the lip?",
    "seeds": [
      "Vascular malformation of the lip"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12488",
    "question": "What is associated with Elevated urine hyaluronic acid level?",
    "seeds": [
      "Elevated urine hyaluronic acid level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12489",
    "question": "What is associated with Pes valgus?",
    "seeds": [
      "Pes valgus"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12490",
    "question": "What is associated with Marsili syndrome?",
    "seeds": [
      "Marsili syndrome"
    ],
    "gold_answer": "Hypohidrosis or hyperhidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12491",
    "question": "What is associated with Scalp edema?",
    "seeds": [
      "Scalp edema"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12492",
    "question": "What phenotype is associated with Congenital bile acid synthesis defect type 1?",
    "seeds": [
      "Congenital bile acid synthesis defect type 1"
    ],
    "gold_answer": "Jaundice",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12493",
    "question": "What is associated with Pneumonia?",
    "seeds": [
      "Pneumonia"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12494",
    "question": "What is associated with Scapulohumeral synostosis?",
    "seeds": [
      "Scapulohumeral synostosis"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12495",
    "question": "What is associated with Sacral dimple?",
    "seeds": [
      "Sacral dimple"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12496",
    "question": "What is associated with Familial apolipoprotein C-II deficiency?",
    "seeds": [
      "Familial apolipoprotein C-II deficiency"
    ],
    "gold_answer": "APOC2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_12497",
    "question": "What is associated with Aplasia/Hypoplasia of the midbrain?",
    "seeds": [
      "Aplasia/Hypoplasia of the midbrain"
    ],
    "gold_answer": "Abnormal midbrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12498",
    "question": "What is associated with Deafness, autosomal dominant 6?",
    "seeds": [
      "Deafness, autosomal dominant 6"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12499",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 85, with or without midline brain defects?",
    "seeds": [
      "Developmental and epileptic encephalopathy 85, with or without midline brain defects"
    ],
    "gold_answer": "Thin upper lip vermilion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12500",
    "question": "What is associated with Foveal hypoplasia and presenile cataract syndromefoveal hypoplasia, isolated, included?",
    "seeds": [
      "Foveal hypoplasia and presenile cataract syndromefoveal hypoplasia, isolated, included"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the fovea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12501",
    "question": "What phenotype is associated with Immune thrombocytopenia?",
    "seeds": [
      "Immune thrombocytopenia"
    ],
    "gold_answer": "Anti-glutamic acid decarboxylase antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12502",
    "question": "What phenotype is associated with Short-rib thoracic dysplasia 12?",
    "seeds": [
      "Short-rib thoracic dysplasia 12"
    ],
    "gold_answer": "Hypoplastic scapulae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12503",
    "question": "What is associated with Elevated circulating 2-hydroxybutyric acid concentration?",
    "seeds": [
      "Elevated circulating 2-hydroxybutyric acid concentration"
    ],
    "gold_answer": "Elevated circulating hydroxybutyric acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12504",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 55, with seizures?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 55, with seizures"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12505",
    "question": "What is associated with Oculomotor apraxia?",
    "seeds": [
      "Oculomotor apraxia"
    ],
    "gold_answer": "Apraxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12506",
    "question": "What phenotype is associated with 22q11.2 duplication syndrome?",
    "seeds": [
      "22q11.2 duplication syndrome"
    ],
    "gold_answer": "Compulsive behaviors",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12507",
    "question": "What is associated with Alveolar rhabdomyosarcoma?",
    "seeds": [
      "Alveolar rhabdomyosarcoma"
    ],
    "gold_answer": "Sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12508",
    "question": "What phenotype is associated with Anemia, nonspherocytic hemolytic, possibly due to defect in porphyrinmetabolism?",
    "seeds": [
      "Anemia, nonspherocytic hemolytic, possibly due to defect in porphyrinmetabolism"
    ],
    "gold_answer": "Nonspherocytic hemolytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12509",
    "question": "What is associated with Glycopeptiduria?",
    "seeds": [
      "Glycopeptiduria"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12510",
    "question": "What is associated with Congenital megacalycosis?",
    "seeds": [
      "Congenital megacalycosis"
    ],
    "gold_answer": "Dilatation of the renal pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12511",
    "question": "What phenotype is associated with Dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome?",
    "seeds": [
      "Dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome"
    ],
    "gold_answer": "Precocious puberty",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12512",
    "question": "What is associated with Intellectual developmental disorder, X-linked 113?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 113"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12513",
    "question": "What is associated with Inclusion body myositis?",
    "seeds": [
      "Inclusion body myositis"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12514",
    "question": "What is associated with Irregular epiphysis of the middle phalanx of the 2nd toe?",
    "seeds": [
      "Irregular epiphysis of the middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal second toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12515",
    "question": "What is associated with Congenital disorder of glycosylation, type IIr?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIr"
    ],
    "gold_answer": "Abnormal elasticity of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12516",
    "question": "What phenotype is associated with EAR WAX, WET/DRY?",
    "seeds": [
      "EAR WAX, WET/DRY"
    ],
    "gold_answer": "Abnormality of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12517",
    "question": "What is associated with Fetal intra-abdominal umbilical vein varix?",
    "seeds": [
      "Fetal intra-abdominal umbilical vein varix"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12518",
    "question": "What is associated with Abnormal femoral neck/head morphology?",
    "seeds": [
      "Abnormal femoral neck/head morphology"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12519",
    "question": "What is associated with Feeding difficulties?",
    "seeds": [
      "Feeding difficulties"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12520",
    "question": "What is associated with Delayed patellar ossification?",
    "seeds": [
      "Delayed patellar ossification"
    ],
    "gold_answer": "Abnormal bone structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12521",
    "question": "What phenotype is associated with Fanconi anemia, complementation group W?",
    "seeds": [
      "Fanconi anemia, complementation group W"
    ],
    "gold_answer": "Intrauterine growth retardation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12522",
    "question": "What is associated with Immunodeficiency 123 with HPV-related verrucosis?",
    "seeds": [
      "Immunodeficiency 123 with HPV-related verrucosis"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12523",
    "question": "What is associated with Paracentral?",
    "seeds": [
      "Paracentral"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12524",
    "question": "What is associated with Panniculitis?",
    "seeds": [
      "Panniculitis"
    ],
    "gold_answer": "Abnormal adipose tissue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12525",
    "question": "What is associated with Hypoplasia of the femoral head?",
    "seeds": [
      "Hypoplasia of the femoral head"
    ],
    "gold_answer": "Abnormal femoral neck/head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12526",
    "question": "What is associated with Pulmonary xanthomatosis?",
    "seeds": [
      "Pulmonary xanthomatosis"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12527",
    "question": "What is associated with Osteoporosis of vertebrae?",
    "seeds": [
      "Osteoporosis of vertebrae"
    ],
    "gold_answer": "Osteoporosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12528",
    "question": "What is associated with Intellectual developmental disorder, X-linked 30?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 30"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12529",
    "question": "What is associated with Polymicrogyria, bilateral perisylvian, X-linked?",
    "seeds": [
      "Polymicrogyria, bilateral perisylvian, X-linked"
    ],
    "gold_answer": "Abnormal cortical gyration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12530",
    "question": "What is associated with Anti-measles antibody positivity?",
    "seeds": [
      "Anti-measles antibody positivity"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12531",
    "question": "What is associated with Double eyebrow?",
    "seeds": [
      "Double eyebrow"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12532",
    "question": "What is associated with Neurodevelopmental disorder with infantile epileptic spasms?",
    "seeds": [
      "Neurodevelopmental disorder with infantile epileptic spasms"
    ],
    "gold_answer": "Delayed gross motor development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12533",
    "question": "What is associated with Posterior uveitis?",
    "seeds": [
      "Posterior uveitis"
    ],
    "gold_answer": "Inflammatory abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12534",
    "question": "What is associated with Hepatic vein thrombosis?",
    "seeds": [
      "Hepatic vein thrombosis"
    ],
    "gold_answer": "Splanchnic vein thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12535",
    "question": "What is associated with Mirror image polydactyly?",
    "seeds": [
      "Mirror image polydactyly"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12536",
    "question": "What is associated with Anti-CARP VIII antibody?",
    "seeds": [
      "Anti-CARP VIII antibody"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12537",
    "question": "What is associated with Thenar muscle weakness?",
    "seeds": [
      "Thenar muscle weakness"
    ],
    "gold_answer": "Abnormality of the musculature of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12538",
    "question": "What is associated with Bleeding disorder, platelet-type, 16?",
    "seeds": [
      "Bleeding disorder, platelet-type, 16"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12539",
    "question": "What is associated with Thalamic edema?",
    "seeds": [
      "Thalamic edema"
    ],
    "gold_answer": "Abnormal diencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12540",
    "question": "What is associated with Beemer-Ertbruggen syndrome?",
    "seeds": [
      "Beemer-Ertbruggen syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the mandible",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12541",
    "question": "What is associated with Anemia, congenital dyserythropoietic, type Ia?",
    "seeds": [
      "Anemia, congenital dyserythropoietic, type Ia"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12542",
    "question": "What is associated with Mitochondrial DNA depletion syndrome 3 (hepatocerebral type)?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome 3 (hepatocerebral type)"
    ],
    "gold_answer": "Acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12543",
    "question": "What is associated with Triangular shaped phalanges of the 2nd finger?",
    "seeds": [
      "Triangular shaped phalanges of the 2nd finger"
    ],
    "gold_answer": "Abnormal 2nd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12544",
    "question": "What is associated with Short-Rib thoracic dysplasia 20 with polydactyly?",
    "seeds": [
      "Short-Rib thoracic dysplasia 20 with polydactyly"
    ],
    "gold_answer": "Craniofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12545",
    "question": "What is associated with Absent distal phalanx of the 3rd toe?",
    "seeds": [
      "Absent distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal third toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12546",
    "question": "What is associated with Dermatosis papulosa nigra?",
    "seeds": [
      "Dermatosis papulosa nigra"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12547",
    "question": "What is associated with Aortic valve calcification?",
    "seeds": [
      "Aortic valve calcification"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12548",
    "question": "What is associated with Schisis association?",
    "seeds": [
      "Schisis association"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12549",
    "question": "What is associated with ANONYCHIA-ECTRODACTYLY?",
    "seeds": [
      "ANONYCHIA-ECTRODACTYLY"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12550",
    "question": "What phenotype is associated with Cinca syndrome?",
    "seeds": [
      "Cinca syndrome"
    ],
    "gold_answer": "Lymphedema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12551",
    "question": "What is associated with History of wearing tightly fitted clothing?",
    "seeds": [
      "History of wearing tightly fitted clothing"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12552",
    "question": "What is associated with DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion?",
    "seeds": [
      "DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion"
    ],
    "gold_answer": "Coloboma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12553",
    "question": "What is associated with Thickened fibular cortex?",
    "seeds": [
      "Thickened fibular cortex"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12554",
    "question": "What is associated with Enlarged cochlear aqueduct?",
    "seeds": [
      "Enlarged cochlear aqueduct"
    ],
    "gold_answer": "Abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12555",
    "question": "What is associated with Short N2 sleep?",
    "seeds": [
      "Short N2 sleep"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12556",
    "question": "What phenotype is associated with Young-onset Parkinson disease?",
    "seeds": [
      "Young-onset Parkinson disease"
    ],
    "gold_answer": "Postural instability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12557",
    "question": "What phenotype is associated with Blomstrand lethal chondrodysplasia?",
    "seeds": [
      "Blomstrand lethal chondrodysplasia"
    ],
    "gold_answer": "Spontaneous abortion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12558",
    "question": "What phenotype is associated with Epilepsy, nocturnal frontal lobe, 2?",
    "seeds": [
      "Epilepsy, nocturnal frontal lobe, 2"
    ],
    "gold_answer": "Aggressive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12559",
    "question": "What is associated with Reduced cell surface marker level?",
    "seeds": [
      "Reduced cell surface marker level"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12560",
    "question": "What is associated with 46,XY sex reversal 10?",
    "seeds": [
      "46,XY sex reversal 10"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the testes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12561",
    "question": "What phenotype is associated with Meckel syndrome 3?",
    "seeds": [
      "Meckel syndrome 3"
    ],
    "gold_answer": "Hepatic fibrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12562",
    "question": "What phenotype is associated with Vohwinkel syndrome, variant form?",
    "seeds": [
      "Vohwinkel syndrome, variant form"
    ],
    "gold_answer": "Hypergranulosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12563",
    "question": "What is associated with Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome?",
    "seeds": [
      "Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12564",
    "question": "What is associated with Noonan syndrome 7?",
    "seeds": [
      "Noonan syndrome 7"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12565",
    "question": "What is associated with Reduced tissue thymidine phosphorylase activity?",
    "seeds": [
      "Reduced tissue thymidine phosphorylase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12566",
    "question": "What is associated with Trident pelvis?",
    "seeds": [
      "Trident pelvis"
    ],
    "gold_answer": "Abnormal hip joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12567",
    "question": "What is associated with Splenic lipid-laden macrophage infiltration?",
    "seeds": [
      "Splenic lipid-laden macrophage infiltration"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12568",
    "question": "What phenotype is associated with Vitreoretinopathy, neovascular inflammatory?",
    "seeds": [
      "Vitreoretinopathy, neovascular inflammatory"
    ],
    "gold_answer": "Retinal detachment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12569",
    "question": "What is associated with Partial duplication of the middle phalanx of the 2nd toe?",
    "seeds": [
      "Partial duplication of the middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Duplication of the phalanges of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12570",
    "question": "What is associated with Mucolipidosis III alpha/beta?",
    "seeds": [
      "Mucolipidosis III alpha/beta"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12571",
    "question": "What is associated with Isolated sulfite oxidase deficiency?",
    "seeds": [
      "Isolated sulfite oxidase deficiency"
    ],
    "gold_answer": "SUOX",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12572",
    "question": "What is associated with Alopecia, familial focal?",
    "seeds": [
      "Alopecia, familial focal"
    ],
    "gold_answer": "Acquired abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12573",
    "question": "What is associated with Hemoglobin E-beta-thalassemia major?",
    "seeds": [
      "Hemoglobin E-beta-thalassemia major"
    ],
    "gold_answer": "HBB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12574",
    "question": "What is associated with Classic glucose transporter type 1 deficiency syndrome?",
    "seeds": [
      "Classic glucose transporter type 1 deficiency syndrome"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12575",
    "question": "What is associated with Hypomelanosis of Ito?",
    "seeds": [
      "Hypomelanosis of Ito"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12576",
    "question": "What is associated with Imerslund-Grasbeck syndrome 2?",
    "seeds": [
      "Imerslund-Grasbeck syndrome 2"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12577",
    "question": "What is associated with Axial malrotation of the kidney?",
    "seeds": [
      "Axial malrotation of the kidney"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12578",
    "question": "What is associated with Depression?",
    "seeds": [
      "Depression"
    ],
    "gold_answer": "Abnormal emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12579",
    "question": "What is associated with Rhomboid or triangular shaped 5th finger proximal phalanx?",
    "seeds": [
      "Rhomboid or triangular shaped 5th finger proximal phalanx"
    ],
    "gold_answer": "Abnormality of the proximal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12580",
    "question": "What is associated with Scholte syndrome?",
    "seeds": [
      "Scholte syndrome"
    ],
    "gold_answer": "Abnormal penis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12581",
    "question": "What is associated with Short phalanx of the 5th toe?",
    "seeds": [
      "Short phalanx of the 5th toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12582",
    "question": "What is associated with Isolated hemihyperplasia?",
    "seeds": [
      "Isolated hemihyperplasia"
    ],
    "gold_answer": "Hematuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12583",
    "question": "What is associated with Osteootohepatoenteric syndrome?",
    "seeds": [
      "Osteootohepatoenteric syndrome"
    ],
    "gold_answer": "Abnormal small intestinal mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12584",
    "question": "What is associated with Erythroleukemia, familial, susceptibility to?",
    "seeds": [
      "Erythroleukemia, familial, susceptibility to"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12585",
    "question": "What is associated with Ectopic ureteral orifice?",
    "seeds": [
      "Ectopic ureteral orifice"
    ],
    "gold_answer": "Abnormal ureter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12586",
    "question": "What is associated with Flattened metatarsal heads?",
    "seeds": [
      "Flattened metatarsal heads"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12587",
    "question": "What is associated with Proteinuria?",
    "seeds": [
      "Proteinuria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12588",
    "question": "What is associated with Focal aware head nodding automatism seizure?",
    "seeds": [
      "Focal aware head nodding automatism seizure"
    ],
    "gold_answer": "Focal aware seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12589",
    "question": "What is associated with Angulated humerus?",
    "seeds": [
      "Angulated humerus"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12590",
    "question": "What is associated with Infantile spasms-broad thumbs syndrome?",
    "seeds": [
      "Infantile spasms-broad thumbs syndrome"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12591",
    "question": "What is associated with Abnormal Descemet membrane morphology?",
    "seeds": [
      "Abnormal Descemet membrane morphology"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12592",
    "question": "What phenotype is associated with Ectodermal dysplasia 11A, hypohidrotic/hair/tooth type, autosomal dominant?",
    "seeds": [
      "Ectodermal dysplasia 11A, hypohidrotic/hair/tooth type, autosomal dominant"
    ],
    "gold_answer": "Sparse hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12593",
    "question": "What is associated with Elevated circulating C5 acylcarnitine concentration?",
    "seeds": [
      "Elevated circulating C5 acylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12594",
    "question": "What is associated with Duplication of the middle phalanx of the 5th finger?",
    "seeds": [
      "Duplication of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12595",
    "question": "What is associated with Absent pigmentation of chest?",
    "seeds": [
      "Absent pigmentation of chest"
    ],
    "gold_answer": "Hypopigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12596",
    "question": "What is associated with Discoid adrenal gland?",
    "seeds": [
      "Discoid adrenal gland"
    ],
    "gold_answer": "Abnormality of the adrenal glands",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12597",
    "question": "What is associated with Uterine neoplasm?",
    "seeds": [
      "Uterine neoplasm"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12598",
    "question": "What is associated with Anti-Powassan virus antibody positivity?",
    "seeds": [
      "Anti-Powassan virus antibody positivity"
    ],
    "gold_answer": "Bloodstream virus-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12599",
    "question": "What is associated with Wide capital femoral epiphyses?",
    "seeds": [
      "Wide capital femoral epiphyses"
    ],
    "gold_answer": "Abnormal femoral epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12600",
    "question": "What phenotype is associated with Patent ductus arteriosus 3?",
    "seeds": [
      "Patent ductus arteriosus 3"
    ],
    "gold_answer": "Patent ductus arteriosus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12601",
    "question": "What phenotype is associated with Ectodermal dysplasia 13, Hair/tooth type?",
    "seeds": [
      "Ectodermal dysplasia 13, Hair/tooth type"
    ],
    "gold_answer": "Low anterior hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12602",
    "question": "What is associated with Autism?",
    "seeds": [
      "Autism"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12603",
    "question": "What is associated with Rapid-onset dystonia-parkinsonism?",
    "seeds": [
      "Rapid-onset dystonia-parkinsonism"
    ],
    "gold_answer": "Abnormal emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12604",
    "question": "What is associated with Microphthalmia, isolated 8?",
    "seeds": [
      "Microphthalmia, isolated 8"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12605",
    "question": "What is associated with Osteosclerosis - ichthyosis - premature ovarian failure?",
    "seeds": [
      "Osteosclerosis - ichthyosis - premature ovarian failure"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12606",
    "question": "What phenotype is associated with Rhabdoid tumor predisposition syndrome 1?",
    "seeds": [
      "Rhabdoid tumor predisposition syndrome 1"
    ],
    "gold_answer": "Vertigo",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12607",
    "question": "What is associated with Recurrent cutaneous abscess formation?",
    "seeds": [
      "Recurrent cutaneous abscess formation"
    ],
    "gold_answer": "Abnormal immune system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12608",
    "question": "What is associated with Spinocerebellar ataxia 41?",
    "seeds": [
      "Spinocerebellar ataxia 41"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12609",
    "question": "What phenotype is associated with Retinoblastoma?",
    "seeds": [
      "Retinoblastoma"
    ],
    "gold_answer": "Progressive visual field defects",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12610",
    "question": "What phenotype is associated with Microcephaly, short stature, and impaired glucose metabolism 2?",
    "seeds": [
      "Microcephaly, short stature, and impaired glucose metabolism 2"
    ],
    "gold_answer": "Epicanthus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12611",
    "question": "What is associated with Chiari type II malformation?",
    "seeds": [
      "Chiari type II malformation"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12612",
    "question": "What is associated with Bracket epiphysis of the distal phalanx of the hallux?",
    "seeds": [
      "Bracket epiphysis of the distal phalanx of the hallux"
    ],
    "gold_answer": "Bracket epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12613",
    "question": "What is associated with Predominantly dermal neutrophilic infiltrate?",
    "seeds": [
      "Predominantly dermal neutrophilic infiltrate"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12614",
    "question": "What is associated with Aplasia/Hypoplasia of the iris?",
    "seeds": [
      "Aplasia/Hypoplasia of the iris"
    ],
    "gold_answer": "Aplasia/Hypoplasia affecting the anterior segment of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12615",
    "question": "What phenotype is associated with Microscopic polyangiitis?",
    "seeds": [
      "Microscopic polyangiitis"
    ],
    "gold_answer": "Ground-glass opacification on pulmonary HRCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12616",
    "question": "What is associated with Megaloblastic bone marrow?",
    "seeds": [
      "Megaloblastic bone marrow"
    ],
    "gold_answer": "Abnormal bone marrow cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12617",
    "question": "What is associated with Vitamin B3 deficiency?",
    "seeds": [
      "Vitamin B3 deficiency"
    ],
    "gold_answer": "Abnormality of vitamin metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12618",
    "question": "What phenotype is associated with Melanoma, cutaneous malignant?",
    "seeds": [
      "Melanoma, cutaneous malignant"
    ],
    "gold_answer": "Numerous nevi",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12619",
    "question": "What is associated with Immunodeficiency 59 and hypoglycemia?",
    "seeds": [
      "Immunodeficiency 59 and hypoglycemia"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the skull",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12620",
    "question": "What is associated with Delayed recoil upon stretching of skin?",
    "seeds": [
      "Delayed recoil upon stretching of skin"
    ],
    "gold_answer": "Abnormally lax or hyperextensible skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12621",
    "question": "What is associated with Anterior chamber cyst?",
    "seeds": [
      "Anterior chamber cyst"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12622",
    "question": "What is associated with Urocanic aciduria?",
    "seeds": [
      "Urocanic aciduria"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12623",
    "question": "What phenotype is associated with Mitochondrial complex I deficiency, nuclear type 7?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 7"
    ],
    "gold_answer": "Hypertrophic cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12624",
    "question": "What is associated with Complete duplication of the middle phalanges of the hand?",
    "seeds": [
      "Complete duplication of the middle phalanges of the hand"
    ],
    "gold_answer": "Abnormal middle phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12625",
    "question": "What is associated with Focal non-convulsive status epilepticus with impairment of consciousness?",
    "seeds": [
      "Focal non-convulsive status epilepticus with impairment of consciousness"
    ],
    "gold_answer": "Non-convulsive status epilepticus without coma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12626",
    "question": "What is associated with Narrow foramen obturatorium?",
    "seeds": [
      "Narrow foramen obturatorium"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12627",
    "question": "What is associated with Parathyroid adenoma?",
    "seeds": [
      "Parathyroid adenoma"
    ],
    "gold_answer": "Neoplasm of the parathyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12628",
    "question": "What is associated with Salt and pepper developmental regression syndrome?",
    "seeds": [
      "Salt and pepper developmental regression syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12629",
    "question": "What is associated with Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome?",
    "seeds": [
      "Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome"
    ],
    "gold_answer": "Limited elbow movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12630",
    "question": "What phenotype is associated with Adult idiopathic neutropenia?",
    "seeds": [
      "Adult idiopathic neutropenia"
    ],
    "gold_answer": "Helicobacter pylori infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12631",
    "question": "What is associated with Complete duplication of thumb phalanx?",
    "seeds": [
      "Complete duplication of thumb phalanx"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12632",
    "question": "What is associated with Congenital neuroblastoma?",
    "seeds": [
      "Congenital neuroblastoma"
    ],
    "gold_answer": "Neuroblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12633",
    "question": "What is associated with Irregular epiphyses of the 5th toe?",
    "seeds": [
      "Irregular epiphyses of the 5th toe"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12634",
    "question": "What phenotype is associated with Progressive external ophthalmoplegia-myopathy-emaciation syndrome?",
    "seeds": [
      "Progressive external ophthalmoplegia-myopathy-emaciation syndrome"
    ],
    "gold_answer": "Kyphosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12635",
    "question": "What is associated with Ventricular tachycardia, familial?",
    "seeds": [
      "Ventricular tachycardia, familial"
    ],
    "gold_answer": "Sudden death",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12636",
    "question": "What is associated with CD19 expression?",
    "seeds": [
      "CD19 expression"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12637",
    "question": "What phenotype is associated with Diamond-Blackfan anemia 5?",
    "seeds": [
      "Diamond-Blackfan anemia 5"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12638",
    "question": "What is associated with Hydroureter?",
    "seeds": [
      "Hydroureter"
    ],
    "gold_answer": "Abnormality of the ureter",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12639",
    "question": "What is associated with Decreased circulating acid maltase activity?",
    "seeds": [
      "Decreased circulating acid maltase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12640",
    "question": "What is associated with Hypoammonemia?",
    "seeds": [
      "Hypoammonemia"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12641",
    "question": "What phenotype is associated with Lowry-MacLean syndrome?",
    "seeds": [
      "Lowry-MacLean syndrome"
    ],
    "gold_answer": "Stroke",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12642",
    "question": "What is associated with Dalen-Fuchs nodules?",
    "seeds": [
      "Dalen-Fuchs nodules"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12643",
    "question": "What is associated with Fractured lower limb segment?",
    "seeds": [
      "Fractured lower limb segment"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12644",
    "question": "What is associated with PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome?",
    "seeds": [
      "PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome"
    ],
    "gold_answer": "NDP",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_12645",
    "question": "What phenotype is associated with Gaucher disease type 3?",
    "seeds": [
      "Gaucher disease type 3"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12646",
    "question": "What is associated with High myopia?",
    "seeds": [
      "High myopia"
    ],
    "gold_answer": "Myopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12647",
    "question": "What phenotype is associated with Collagenoma, familial cutaneous?",
    "seeds": [
      "Collagenoma, familial cutaneous"
    ],
    "gold_answer": "Collagenoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12648",
    "question": "What is associated with Reduced brain N-acetyl aspartate level by MRS?",
    "seeds": [
      "Reduced brain N-acetyl aspartate level by MRS"
    ],
    "gold_answer": "Abnormal brain N-acetyl aspartate level by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12649",
    "question": "What is associated with Brachymorphism-onychodysplasia-dysphalangism syndrome?",
    "seeds": [
      "Brachymorphism-onychodysplasia-dysphalangism syndrome"
    ],
    "gold_answer": "Absent toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12650",
    "question": "What is associated with Positive respiratory tract SARS-CoV-2 coronavirus nucleic acid test?",
    "seeds": [
      "Positive respiratory tract SARS-CoV-2 coronavirus nucleic acid test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12651",
    "question": "What is associated with Periodontal Ehlers-Danlos syndrome?",
    "seeds": [
      "Periodontal Ehlers-Danlos syndrome"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12652",
    "question": "What is associated with Systemic mastocytosis with associated hematologic neoplasm?",
    "seeds": [
      "Systemic mastocytosis with associated hematologic neoplasm"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12653",
    "question": "What is associated with Gaisböck syndrome?",
    "seeds": [
      "Gaisböck syndrome"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12654",
    "question": "What is associated with Varicocele?",
    "seeds": [
      "Varicocele"
    ],
    "gold_answer": "Abnormal scrotum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12655",
    "question": "What is associated with Brain imaging abnormality?",
    "seeds": [
      "Brain imaging abnormality"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12656",
    "question": "What is associated with Anti-endomysial antibody positivity?",
    "seeds": [
      "Anti-endomysial antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12657",
    "question": "What is associated with Tubulinopathy-associated dysgyria?",
    "seeds": [
      "Tubulinopathy-associated dysgyria"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12658",
    "question": "What is associated with Diamond-Blackfan anemia 20?",
    "seeds": [
      "Diamond-Blackfan anemia 20"
    ],
    "gold_answer": "Abnormal number of erythroid precursors",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12659",
    "question": "What phenotype is associated with Methylmalonic acidemia with homocystinuria?",
    "seeds": [
      "Methylmalonic acidemia with homocystinuria"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12660",
    "question": "What is associated with Hypoalphalipoproteinemia, primary, 2?",
    "seeds": [
      "Hypoalphalipoproteinemia, primary, 2"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12661",
    "question": "What is associated with Ameliorated by pregnancy?",
    "seeds": [
      "Ameliorated by pregnancy"
    ],
    "gold_answer": "Ameliorated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12662",
    "question": "What is associated with Ring chromosome 8 syndrome?",
    "seeds": [
      "Ring chromosome 8 syndrome"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12663",
    "question": "What is associated with Anomalous insertion of papillary muscle directly into anterior mitral leaflet?",
    "seeds": [
      "Anomalous insertion of papillary muscle directly into anterior mitral leaflet"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12664",
    "question": "What phenotype is associated with Basal laminar drusen?",
    "seeds": [
      "Basal laminar drusen"
    ],
    "gold_answer": "Progressive visual loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12665",
    "question": "What is associated with Absent right sided atrioventricular connection?",
    "seeds": [
      "Absent right sided atrioventricular connection"
    ],
    "gold_answer": "Abnormal atrioventricular connection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12666",
    "question": "What is associated with Gracile bone dysplasia?",
    "seeds": [
      "Gracile bone dysplasia"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12667",
    "question": "What is associated with Antenatal intracerebral hemorrhage?",
    "seeds": [
      "Antenatal intracerebral hemorrhage"
    ],
    "gold_answer": "Cerebral hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12668",
    "question": "What is associated with 46, XY sex reversal 11?",
    "seeds": [
      "46, XY sex reversal 11"
    ],
    "gold_answer": "Increased circulating gonadotropin level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12669",
    "question": "What is associated with Lethal congenital contracture syndrome 1?",
    "seeds": [
      "Lethal congenital contracture syndrome 1"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the skull",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12670",
    "question": "What is associated with Epidermolysis bullosa acquisita?",
    "seeds": [
      "Epidermolysis bullosa acquisita"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12671",
    "question": "What is associated with Neonatal electro-clinical non-motor seizure?",
    "seeds": [
      "Neonatal electro-clinical non-motor seizure"
    ],
    "gold_answer": "Neonatal seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12672",
    "question": "What is associated with Positive enterovirus urine nucleic acid test?",
    "seeds": [
      "Positive enterovirus urine nucleic acid test"
    ],
    "gold_answer": "Positive urine infectious agent nucleic acid test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12673",
    "question": "What is associated with Elevated aromatase activity?",
    "seeds": [
      "Elevated aromatase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12674",
    "question": "What is associated with Overhanging nasal tip?",
    "seeds": [
      "Overhanging nasal tip"
    ],
    "gold_answer": "Abnormal nasal tip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12675",
    "question": "What is associated with Cystic medial necrosis?",
    "seeds": [
      "Cystic medial necrosis"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12676",
    "question": "What is associated with LENTIGINES?",
    "seeds": [
      "LENTIGINES"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12677",
    "question": "What is associated with Limited elbow extension and supination?",
    "seeds": [
      "Limited elbow extension and supination"
    ],
    "gold_answer": "Limited elbow extension",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12678",
    "question": "What is associated with Hyperlysinemia?",
    "seeds": [
      "Hyperlysinemia"
    ],
    "gold_answer": "Azotemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12679",
    "question": "What is associated with Stüve-Wiedemann syndrome?",
    "seeds": [
      "Stüve-Wiedemann syndrome"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12680",
    "question": "What is associated with Leg muscle stiffness?",
    "seeds": [
      "Leg muscle stiffness"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12681",
    "question": "What is associated with Abnormal interlobular vein intima/media morphology?",
    "seeds": [
      "Abnormal interlobular vein intima/media morphology"
    ],
    "gold_answer": "Abnormal intrarenal vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12682",
    "question": "What phenotype is associated with Congenital glaucoma?",
    "seeds": [
      "Congenital glaucoma"
    ],
    "gold_answer": "Reduced anterior scleral thickness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12683",
    "question": "What is associated with Auriculitis?",
    "seeds": [
      "Auriculitis"
    ],
    "gold_answer": "Abnormal ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12684",
    "question": "What is associated with Congenital curved nail of fourth toe?",
    "seeds": [
      "Congenital curved nail of fourth toe"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12685",
    "question": "What is associated with Esophageal squamous papilloma?",
    "seeds": [
      "Esophageal squamous papilloma"
    ],
    "gold_answer": "Esophageal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12686",
    "question": "What is associated with Placenta increta?",
    "seeds": [
      "Placenta increta"
    ],
    "gold_answer": "Abnormal placenta morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12687",
    "question": "What is associated with Anti-thyroglobulin antibody positivity?",
    "seeds": [
      "Anti-thyroglobulin antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12688",
    "question": "What is associated with Susceptibility to infection due to TYK2 deficiency?",
    "seeds": [
      "Susceptibility to infection due to TYK2 deficiency"
    ],
    "gold_answer": "TYK2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_12689",
    "question": "What is associated with Hypoplastic fetal nasal bone?",
    "seeds": [
      "Hypoplastic fetal nasal bone"
    ],
    "gold_answer": "Abnormal fetal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12690",
    "question": "What phenotype is associated with Hydrocephaly-tall stature-joint laxity syndrome?",
    "seeds": [
      "Hydrocephaly-tall stature-joint laxity syndrome"
    ],
    "gold_answer": "Disproportionate tall stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12691",
    "question": "What is associated with Short metacarpal?",
    "seeds": [
      "Short metacarpal"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12692",
    "question": "What is associated with Elevated circulating tenascin-C concentration?",
    "seeds": [
      "Elevated circulating tenascin-C concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12693",
    "question": "What is associated with Meromelia?",
    "seeds": [
      "Meromelia"
    ],
    "gold_answer": "Limb undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12694",
    "question": "What is associated with Frontometaphyseal dysplasia 2?",
    "seeds": [
      "Frontometaphyseal dysplasia 2"
    ],
    "gold_answer": "Abnormality of the pylorus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12695",
    "question": "What is associated with Hyperkeratosis?",
    "seeds": [
      "Hyperkeratosis"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12696",
    "question": "What is associated with Upper extremity akinesia?",
    "seeds": [
      "Upper extremity akinesia"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12697",
    "question": "What is associated with Arachnoid granulation?",
    "seeds": [
      "Arachnoid granulation"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12698",
    "question": "What is associated with Congenital pyloric atresia?",
    "seeds": [
      "Congenital pyloric atresia"
    ],
    "gold_answer": "Abnormality of the pylorus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12699",
    "question": "What is associated with Essential fructosuria?",
    "seeds": [
      "Essential fructosuria"
    ],
    "gold_answer": "Abnormal glucose homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12700",
    "question": "What phenotype is associated with PLAA-associated neurodevelopmental disorder?",
    "seeds": [
      "PLAA-associated neurodevelopmental disorder"
    ],
    "gold_answer": "Bulbar palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12701",
    "question": "What phenotype is associated with Noonan syndrome 12?",
    "seeds": [
      "Noonan syndrome 12"
    ],
    "gold_answer": "Dolichocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12702",
    "question": "What is associated with Oral mucosal blisters?",
    "seeds": [
      "Oral mucosal blisters"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12703",
    "question": "What phenotype is associated with Autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome?",
    "seeds": [
      "Autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome"
    ],
    "gold_answer": "Short femur",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12704",
    "question": "What is associated with Conjunctival icterus?",
    "seeds": [
      "Conjunctival icterus"
    ],
    "gold_answer": "Abnormal conjunctiva morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12705",
    "question": "What phenotype is associated with MALT lymphoma?",
    "seeds": [
      "MALT lymphoma"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12706",
    "question": "What phenotype is associated with Corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia?",
    "seeds": [
      "Corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia"
    ],
    "gold_answer": "Everted lower lip vermilion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12707",
    "question": "What is associated with Left ventricular rupture?",
    "seeds": [
      "Left ventricular rupture"
    ],
    "gold_answer": "Abnormal cardiac ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12708",
    "question": "What is associated with Absent left main coronary artery?",
    "seeds": [
      "Absent left main coronary artery"
    ],
    "gold_answer": "Abnormal coronary artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12709",
    "question": "What is associated with Abnormality of the dentition?",
    "seeds": [
      "Abnormality of the dentition"
    ],
    "gold_answer": "Abnormality of the mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12710",
    "question": "What is associated with Intercrural pterygium?",
    "seeds": [
      "Intercrural pterygium"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12711",
    "question": "What is associated with Transient bullous dermolysis of the newborn?",
    "seeds": [
      "Transient bullous dermolysis of the newborn"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12712",
    "question": "What is associated with 1-3 toe syndactyly?",
    "seeds": [
      "1-3 toe syndactyly"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12713",
    "question": "What is associated with Abnormal sweat gland morphology?",
    "seeds": [
      "Abnormal sweat gland morphology"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12714",
    "question": "What phenotype is associated with Combined deficiency of factor V and factor VIII type 2?",
    "seeds": [
      "Combined deficiency of factor V and factor VIII type 2"
    ],
    "gold_answer": "Reduced coagulation factor V activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12715",
    "question": "What is associated with Oculopharyngodistal myopathy?",
    "seeds": [
      "Oculopharyngodistal myopathy"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12716",
    "question": "What is associated with Decreased immunoglobulin level in body fluid?",
    "seeds": [
      "Decreased immunoglobulin level in body fluid"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12717",
    "question": "What is associated with Lipodystrophy, familial partial, type 3?",
    "seeds": [
      "Lipodystrophy, familial partial, type 3"
    ],
    "gold_answer": "Storage in hepatocytes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12718",
    "question": "What is associated with Curved proximal phalanx of the 5th finger?",
    "seeds": [
      "Curved proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12719",
    "question": "What is associated with Anonychia?",
    "seeds": [
      "Anonychia"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12720",
    "question": "What is associated with Symmetrical progressive peripheral demyelination?",
    "seeds": [
      "Symmetrical progressive peripheral demyelination"
    ],
    "gold_answer": "Abnormal peripheral myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12721",
    "question": "What is associated with Spermatogenic failure 75?",
    "seeds": [
      "Spermatogenic failure 75"
    ],
    "gold_answer": "Abnormal spermatogenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12722",
    "question": "What is associated with Abnormality of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Abnormality of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12723",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 30, atrial?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 30, atrial"
    ],
    "gold_answer": "Abnormal left ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12724",
    "question": "What is associated with Duplication of phalanx of the 4th toe?",
    "seeds": [
      "Duplication of phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal fourth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12725",
    "question": "What is associated with RIN2 syndrome?",
    "seeds": [
      "RIN2 syndrome"
    ],
    "gold_answer": "Abnormality of the gingiva",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12726",
    "question": "What is associated with Abnormal cutaneous elastic fiber morphology?",
    "seeds": [
      "Abnormal cutaneous elastic fiber morphology"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12727",
    "question": "What is associated with Li-Fraumeni syndrome 2?",
    "seeds": [
      "Li-Fraumeni syndrome 2"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12728",
    "question": "What is associated with Microcephaly-brachydactyly-kyphoscoliosis syndrome?",
    "seeds": [
      "Microcephaly-brachydactyly-kyphoscoliosis syndrome"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12729",
    "question": "What phenotype is associated with Torsion dystonia with onset in infancy?",
    "seeds": [
      "Torsion dystonia with onset in infancy"
    ],
    "gold_answer": "Torsion dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12730",
    "question": "What phenotype is associated with Alar cartilages hypoplasia-coloboma-telecanthus syndrome?",
    "seeds": [
      "Alar cartilages hypoplasia-coloboma-telecanthus syndrome"
    ],
    "gold_answer": "Cleft ala nasi",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12731",
    "question": "What phenotype is associated with Oslam syndrome?",
    "seeds": [
      "Oslam syndrome"
    ],
    "gold_answer": "Increased circulating lactate dehydrogenase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12732",
    "question": "What is associated with Anti-retroviral therapy exposure?",
    "seeds": [
      "Anti-retroviral therapy exposure"
    ],
    "gold_answer": "Medication history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12733",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type It?",
    "seeds": [
      "Congenital disorder of glycosylation, type It"
    ],
    "gold_answer": "Elevated circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12734",
    "question": "What is associated with Microphthalmia, syndromic 3?",
    "seeds": [
      "Microphthalmia, syndromic 3"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12735",
    "question": "What is associated with First dorsal interossei muscle atrophy?",
    "seeds": [
      "First dorsal interossei muscle atrophy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12736",
    "question": "What is associated with Fibular aplasia-complex brachydactyly syndrome?",
    "seeds": [
      "Fibular aplasia-complex brachydactyly syndrome"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12737",
    "question": "What is associated with Cervical spinal canal stenosis?",
    "seeds": [
      "Cervical spinal canal stenosis"
    ],
    "gold_answer": "Spinal canal stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12738",
    "question": "What is associated with Nodular changes affecting the eyelids?",
    "seeds": [
      "Nodular changes affecting the eyelids"
    ],
    "gold_answer": "Skin nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12739",
    "question": "What is associated with History of compressive dressings?",
    "seeds": [
      "History of compressive dressings"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12740",
    "question": "What is associated with Craniofacial cleft?",
    "seeds": [
      "Craniofacial cleft"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12741",
    "question": "What is associated with Falciform retinal fold?",
    "seeds": [
      "Falciform retinal fold"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12742",
    "question": "What is associated with Abnormal circulating calcitonin concentration?",
    "seeds": [
      "Abnormal circulating calcitonin concentration"
    ],
    "gold_answer": "Abnormal circulating calcium-phosphate regulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12743",
    "question": "What is associated with Parkinson disease, juvenile, type 2?",
    "seeds": [
      "Parkinson disease, juvenile, type 2"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12744",
    "question": "What is associated with Hyperekplexia 4?",
    "seeds": [
      "Hyperekplexia 4"
    ],
    "gold_answer": "Hernia of the abdominal wall",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12745",
    "question": "What is associated with Bullet-shaped proximal phalanx of the hallux?",
    "seeds": [
      "Bullet-shaped proximal phalanx of the hallux"
    ],
    "gold_answer": "Bullet-shaped toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12746",
    "question": "What is associated with Ultra-low vision?",
    "seeds": [
      "Ultra-low vision"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12747",
    "question": "What is associated with Reduced acetylglucosamine-6-sulfatase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced acetylglucosamine-6-sulfatase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12748",
    "question": "What is associated with Adrenal cortical sclerosis?",
    "seeds": [
      "Adrenal cortical sclerosis"
    ],
    "gold_answer": "Abnormal adrenal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12749",
    "question": "What is associated with Abnormal embryonic development?",
    "seeds": [
      "Abnormal embryonic development"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12750",
    "question": "What phenotype is associated with Macrodactyly of fingers?",
    "seeds": [
      "Macrodactyly of fingers"
    ],
    "gold_answer": "Finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12751",
    "question": "What is associated with Lipoatrophy?",
    "seeds": [
      "Lipoatrophy"
    ],
    "gold_answer": "Lipodystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12752",
    "question": "What is associated with Fractured epiphysis of second metacarpal bone?",
    "seeds": [
      "Fractured epiphysis of second metacarpal bone"
    ],
    "gold_answer": "Abnormal 2nd metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12753",
    "question": "What is associated with Reduced responsiveness to social cues?",
    "seeds": [
      "Reduced responsiveness to social cues"
    ],
    "gold_answer": "Reduced social responsiveness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12754",
    "question": "What is associated with Slender proximal phalanx of finger?",
    "seeds": [
      "Slender proximal phalanx of finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12755",
    "question": "What is associated with Mitral valve prolapse?",
    "seeds": [
      "Mitral valve prolapse"
    ],
    "gold_answer": "Abnormal atrioventricular valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12756",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 21?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 21"
    ],
    "gold_answer": "Barrett esophagus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12757",
    "question": "What is associated with Deafness, autosomal recessive 17?",
    "seeds": [
      "Deafness, autosomal recessive 17"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12758",
    "question": "What is associated with Nephrotic syndrome, type 1?",
    "seeds": [
      "Nephrotic syndrome, type 1"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12759",
    "question": "What is associated with Infantile onset?",
    "seeds": [
      "Infantile onset"
    ],
    "gold_answer": "Onset",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12760",
    "question": "What is associated with Conjunctivitis?",
    "seeds": [
      "Conjunctivitis"
    ],
    "gold_answer": "Inflammatory abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12761",
    "question": "What phenotype is associated with Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome?",
    "seeds": [
      "Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome"
    ],
    "gold_answer": "Azoospermia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12762",
    "question": "What is associated with Enchondromatosis, multiple?",
    "seeds": [
      "Enchondromatosis, multiple"
    ],
    "gold_answer": "Enchondroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12763",
    "question": "What phenotype is associated with Mandibulofacial dysostosis with alopecia?",
    "seeds": [
      "Mandibulofacial dysostosis with alopecia"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12764",
    "question": "What is associated with Classic mycosis fungoides?",
    "seeds": [
      "Classic mycosis fungoides"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12765",
    "question": "What is associated with Moyamoya disease 2, susceptibility to?",
    "seeds": [
      "Moyamoya disease 2, susceptibility to"
    ],
    "gold_answer": "Tissue ischemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12766",
    "question": "What is associated with Small intestinal perforation?",
    "seeds": [
      "Small intestinal perforation"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12767",
    "question": "What is associated with Deafness, autosomal dominant 88?",
    "seeds": [
      "Deafness, autosomal dominant 88"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12768",
    "question": "What is associated with Bidirectional shunt?",
    "seeds": [
      "Bidirectional shunt"
    ],
    "gold_answer": "Cardiac shunt",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12769",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 77?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 77"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12770",
    "question": "What is associated with Small hand?",
    "seeds": [
      "Small hand"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12771",
    "question": "What is associated with Glomerular basement membranes powdery deposit?",
    "seeds": [
      "Glomerular basement membranes powdery deposit"
    ],
    "gold_answer": "Abnormal glomerular basement membrane texture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12772",
    "question": "What is associated with Lateral rectus muscle weakness?",
    "seeds": [
      "Lateral rectus muscle weakness"
    ],
    "gold_answer": "Abnormal lateral rectus muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12773",
    "question": "What is associated with Abnormal CSF histidine concentration?",
    "seeds": [
      "Abnormal CSF histidine concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12774",
    "question": "What is associated with Hydrolethalus syndrome 2?",
    "seeds": [
      "Hydrolethalus syndrome 2"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12775",
    "question": "What is associated with Generalized glucocorticoid resistance syndrome?",
    "seeds": [
      "Generalized glucocorticoid resistance syndrome"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12776",
    "question": "What is associated with Autosomal dominant hypocalcemia?",
    "seeds": [
      "Autosomal dominant hypocalcemia"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12777",
    "question": "What is associated with Elevated imprint of the transverse sinuses?",
    "seeds": [
      "Elevated imprint of the transverse sinuses"
    ],
    "gold_answer": "Abnormal skull base morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12778",
    "question": "What is associated with Abnormal distal femoral metaphysis morphology?",
    "seeds": [
      "Abnormal distal femoral metaphysis morphology"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12779",
    "question": "What is associated with Cleft larynx, posteriorstridor, congenital, included?",
    "seeds": [
      "Cleft larynx, posteriorstridor, congenital, included"
    ],
    "gold_answer": "Abnormal larynx physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12780",
    "question": "What is associated with Abnormal circulating thromboxane concentration?",
    "seeds": [
      "Abnormal circulating thromboxane concentration"
    ],
    "gold_answer": "Abnormal circulating unsaturated fatty acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12781",
    "question": "What is associated with Ectopic respiratory mucosa?",
    "seeds": [
      "Ectopic respiratory mucosa"
    ],
    "gold_answer": "Abnormal forearm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12782",
    "question": "What phenotype is associated with Spondylometaphyseal dysplasia, Sedaghatian type?",
    "seeds": [
      "Spondylometaphyseal dysplasia, Sedaghatian type"
    ],
    "gold_answer": "Short metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12783",
    "question": "What is associated with Severe cytomegalovirus infection?",
    "seeds": [
      "Severe cytomegalovirus infection"
    ],
    "gold_answer": "Severe infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12784",
    "question": "What phenotype is associated with Juvenile xanthogranuloma?",
    "seeds": [
      "Juvenile xanthogranuloma"
    ],
    "gold_answer": "Blepharitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12785",
    "question": "What is associated with Abnormality of jaw muscles?",
    "seeds": [
      "Abnormality of jaw muscles"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12786",
    "question": "What is associated with Partial duplication of the proximal phalanx of the 2nd finger?",
    "seeds": [
      "Partial duplication of the proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Polydactyly affecting the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12787",
    "question": "What is associated with Abnormal humeral ossification?",
    "seeds": [
      "Abnormal humeral ossification"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12788",
    "question": "What is associated with Increased circulating A-type natriuretic peptide concentration?",
    "seeds": [
      "Increased circulating A-type natriuretic peptide concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12789",
    "question": "What is associated with Multinucleation of renal tubular epithelial cells?",
    "seeds": [
      "Multinucleation of renal tubular epithelial cells"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12790",
    "question": "What is associated with Focal impaired awareness clonic seizure?",
    "seeds": [
      "Focal impaired awareness clonic seizure"
    ],
    "gold_answer": "Clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12791",
    "question": "What is associated with Nephropathy with pretibial epidermolysis bullosa and deafness?",
    "seeds": [
      "Nephropathy with pretibial epidermolysis bullosa and deafness"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12792",
    "question": "What is associated with Remnants of the hyaloid vascular system?",
    "seeds": [
      "Remnants of the hyaloid vascular system"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12793",
    "question": "What phenotype is associated with Impaired intellectual development, truncal obesity, retinal dystrophy, and micropenis syndrome?",
    "seeds": [
      "Impaired intellectual development, truncal obesity, retinal dystrophy, and micropenis syndrome"
    ],
    "gold_answer": "Truncal obesity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12794",
    "question": "What is associated with Vacuolar myopathy with sarcoplasmic reticulum protein aggregates?",
    "seeds": [
      "Vacuolar myopathy with sarcoplasmic reticulum protein aggregates"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12795",
    "question": "What is associated with Antley-Bixler syndrome without genital anomaly or disorder of steroidogenesis?",
    "seeds": [
      "Antley-Bixler syndrome without genital anomaly or disorder of steroidogenesis"
    ],
    "gold_answer": "FGFR2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12796",
    "question": "What is associated with Beau's lines?",
    "seeds": [
      "Beau's lines"
    ],
    "gold_answer": "Abnormal nail surface",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12797",
    "question": "What is associated with Abnormality of the tarsal bones?",
    "seeds": [
      "Abnormality of the tarsal bones"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12798",
    "question": "What is associated with Hydrocephaly-low insertion umbilicus syndrome?",
    "seeds": [
      "Hydrocephaly-low insertion umbilicus syndrome"
    ],
    "gold_answer": "Deviation of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12799",
    "question": "What phenotype is associated with Short-rib thoracic dysplasia 12?",
    "seeds": [
      "Short-rib thoracic dysplasia 12"
    ],
    "gold_answer": "Urethral valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12800",
    "question": "What is associated with Seizure?",
    "seeds": [
      "Seizure"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12801",
    "question": "What phenotype is associated with Friedreich ataxia, so-called, with optic atrophy and sensorineuraldeafness?",
    "seeds": [
      "Friedreich ataxia, so-called, with optic atrophy and sensorineuraldeafness"
    ],
    "gold_answer": "Optic atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12802",
    "question": "What is associated with Aneurysm, intracranial berry, 12?",
    "seeds": [
      "Aneurysm, intracranial berry, 12"
    ],
    "gold_answer": "Vascular dilatation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12803",
    "question": "What is associated with Blepharocheilodontic syndrome 1?",
    "seeds": [
      "Blepharocheilodontic syndrome 1"
    ],
    "gold_answer": "Abnormality of the anus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12804",
    "question": "What is associated with Split-Hand/foot malformation 3?",
    "seeds": [
      "Split-Hand/foot malformation 3"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12805",
    "question": "What is associated with Congenital malformation of the great arteries?",
    "seeds": [
      "Congenital malformation of the great arteries"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12806",
    "question": "What is associated with Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome?",
    "seeds": [
      "Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12807",
    "question": "What is associated with Astereognosis?",
    "seeds": [
      "Astereognosis"
    ],
    "gold_answer": "Tactile agnosia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12808",
    "question": "What phenotype is associated with Immunodeficiency 59 and hypoglycemia?",
    "seeds": [
      "Immunodeficiency 59 and hypoglycemia"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12809",
    "question": "What is associated with Glycosylphosphatidylinositol biosynthesis defect 18?",
    "seeds": [
      "Glycosylphosphatidylinositol biosynthesis defect 18"
    ],
    "gold_answer": "Decreased fetal movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12810",
    "question": "What is associated with Midline brain calcifications?",
    "seeds": [
      "Midline brain calcifications"
    ],
    "gold_answer": "Cerebral calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12811",
    "question": "What is associated with Increased urinary potassium?",
    "seeds": [
      "Increased urinary potassium"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12812",
    "question": "What phenotype is associated with Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus syndrome?",
    "seeds": [
      "Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus syndrome"
    ],
    "gold_answer": "Atrial septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12813",
    "question": "What is associated with Renal tubular epithelial lipofuscin?",
    "seeds": [
      "Renal tubular epithelial lipofuscin"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12814",
    "question": "What is associated with Ankylosing vertebral hyperostosis with tylosisdiffuse idiopathic skeletal hyperostosis, included?",
    "seeds": [
      "Ankylosing vertebral hyperostosis with tylosisdiffuse idiopathic skeletal hyperostosis, included"
    ],
    "gold_answer": "Hyperostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12815",
    "question": "What is associated with Patchy changes of bone mineral density?",
    "seeds": [
      "Patchy changes of bone mineral density"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12816",
    "question": "What is associated with Pulmonary atresia with intact ventricular septum?",
    "seeds": [
      "Pulmonary atresia with intact ventricular septum"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12817",
    "question": "What is associated with Podocyte microvillous transformation?",
    "seeds": [
      "Podocyte microvillous transformation"
    ],
    "gold_answer": "Abnormal Bowman capsule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12818",
    "question": "What is associated with Plantar pain?",
    "seeds": [
      "Plantar pain"
    ],
    "gold_answer": "Lower limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12819",
    "question": "What is associated with Abnormal circulating cholesterol concentration?",
    "seeds": [
      "Abnormal circulating cholesterol concentration"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12820",
    "question": "What is associated with Bracket epiphysis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Bracket epiphysis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Bracket epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12821",
    "question": "What is associated with Deep S wave in lead V5?",
    "seeds": [
      "Deep S wave in lead V5"
    ],
    "gold_answer": "Abnormal ST segment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12822",
    "question": "What is associated with Juvenile cataract-microcornea-renal glucosuria syndrome?",
    "seeds": [
      "Juvenile cataract-microcornea-renal glucosuria syndrome"
    ],
    "gold_answer": "SLC16A12",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12823",
    "question": "What is associated with Retinal hole?",
    "seeds": [
      "Retinal hole"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12824",
    "question": "What is associated with Anti-phosphatidyl choline antibody positivity?",
    "seeds": [
      "Anti-phosphatidyl choline antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12825",
    "question": "What is associated with Glomerular capillary wire loop deposits?",
    "seeds": [
      "Glomerular capillary wire loop deposits"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12826",
    "question": "What is associated with Increased HDL2a concentration?",
    "seeds": [
      "Increased HDL2a concentration"
    ],
    "gold_answer": "Abnormal HDL subfraction concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12827",
    "question": "What phenotype is associated with Brooke-Spiegler syndrome?",
    "seeds": [
      "Brooke-Spiegler syndrome"
    ],
    "gold_answer": "Milia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12828",
    "question": "What is associated with Leber congenital amaurosis, type I?",
    "seeds": [
      "Leber congenital amaurosis, type I"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12829",
    "question": "What is associated with Pituitary dwarfism?",
    "seeds": [
      "Pituitary dwarfism"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12830",
    "question": "What is associated with Bracket epiphysis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Bracket epiphysis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12831",
    "question": "What is associated with Curved 1st metatarsal?",
    "seeds": [
      "Curved 1st metatarsal"
    ],
    "gold_answer": "Abnormal metatarsal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12832",
    "question": "What is associated with Incyclotropia?",
    "seeds": [
      "Incyclotropia"
    ],
    "gold_answer": "Heterotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12833",
    "question": "What is associated with Hyperostosis, endosteal?",
    "seeds": [
      "Hyperostosis, endosteal"
    ],
    "gold_answer": "Abnormal metatarsal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12834",
    "question": "What is associated with Brachydactyly?",
    "seeds": [
      "Brachydactyly"
    ],
    "gold_answer": "Short digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12835",
    "question": "What is associated with Aerophagia?",
    "seeds": [
      "Aerophagia"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12836",
    "question": "What is associated with Anti-PKCgamma antibody?",
    "seeds": [
      "Anti-PKCgamma antibody"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12837",
    "question": "What is associated with Urinary bladder inflammation?",
    "seeds": [
      "Urinary bladder inflammation"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12838",
    "question": "What is associated with Lennox-Gastaut syndrome?",
    "seeds": [
      "Lennox-Gastaut syndrome"
    ],
    "gold_answer": "DNM1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12839",
    "question": "What is associated with Absent epiphyses of the 3rd finger?",
    "seeds": [
      "Absent epiphyses of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12840",
    "question": "What is associated with Fractured metaphysis of femur?",
    "seeds": [
      "Fractured metaphysis of femur"
    ],
    "gold_answer": "Abnormal lower-limb metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12841",
    "question": "What is associated with Gamma-A-Globulin, defect in assembly of?",
    "seeds": [
      "Gamma-A-Globulin, defect in assembly of"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12842",
    "question": "What is associated with Lingual dystonia?",
    "seeds": [
      "Lingual dystonia"
    ],
    "gold_answer": "Dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12843",
    "question": "What is associated with Interrupted aortic arch?",
    "seeds": [
      "Interrupted aortic arch"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12844",
    "question": "What is associated with Spastic ataxia, Charlevoix-Saguenay type?",
    "seeds": [
      "Spastic ataxia, Charlevoix-Saguenay type"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12845",
    "question": "What is associated with Abnormal hallux phalanx morphology?",
    "seeds": [
      "Abnormal hallux phalanx morphology"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12846",
    "question": "What is associated with Contact lens wearer?",
    "seeds": [
      "Contact lens wearer"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12847",
    "question": "What is associated with Prominent palatine ridges?",
    "seeds": [
      "Prominent palatine ridges"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12848",
    "question": "What phenotype is associated with Combined oxidative phosphorylation deficiency 27?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 27"
    ],
    "gold_answer": "Microvesicular hepatic steatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12849",
    "question": "What is associated with Lower limb asymmetry?",
    "seeds": [
      "Lower limb asymmetry"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12850",
    "question": "What is associated with Impaired distal vibration sensation?",
    "seeds": [
      "Impaired distal vibration sensation"
    ],
    "gold_answer": "Impaired proprioception",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12851",
    "question": "What phenotype is associated with Fanconi anemia, complementation group L?",
    "seeds": [
      "Fanconi anemia, complementation group L"
    ],
    "gold_answer": "Preauricular pit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12852",
    "question": "What is associated with Aplasia of the semicircular canal?",
    "seeds": [
      "Aplasia of the semicircular canal"
    ],
    "gold_answer": "Abnormal semicircular canal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12853",
    "question": "What is associated with Prominent palmar flexion creases?",
    "seeds": [
      "Prominent palmar flexion creases"
    ],
    "gold_answer": "Abnormal skin morphology of the palm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12854",
    "question": "What phenotype is associated with Infantile cerebellar-retinal degeneration?",
    "seeds": [
      "Infantile cerebellar-retinal degeneration"
    ],
    "gold_answer": "Areflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12855",
    "question": "What is associated with Abnormality of the curvature of the cornea?",
    "seeds": [
      "Abnormality of the curvature of the cornea"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12856",
    "question": "What is associated with ANONYCHIA-ECTRODACTYLY?",
    "seeds": [
      "ANONYCHIA-ECTRODACTYLY"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12857",
    "question": "What is associated with Triggered by allergens?",
    "seeds": [
      "Triggered by allergens"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12858",
    "question": "What is associated with Delayed ossification of the clavicle?",
    "seeds": [
      "Delayed ossification of the clavicle"
    ],
    "gold_answer": "Abnormal clavicle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12859",
    "question": "What is associated with Aplasia of the distal phalanx of the 5th finger?",
    "seeds": [
      "Aplasia of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Aplasia of distal finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12860",
    "question": "What is associated with Triangular epiphyses of the 5th finger?",
    "seeds": [
      "Triangular epiphyses of the 5th finger"
    ],
    "gold_answer": "Triangular epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12861",
    "question": "What is associated with Silver-Russell syndrome due to a point mutation?",
    "seeds": [
      "Silver-Russell syndrome due to a point mutation"
    ],
    "gold_answer": "Abnormal location of ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12862",
    "question": "What phenotype is associated with Cardiomyopathy, dilated, 1GG?",
    "seeds": [
      "Cardiomyopathy, dilated, 1GG"
    ],
    "gold_answer": "Congestive heart failure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12863",
    "question": "What is associated with 20q13.33 microdeletion syndrome?",
    "seeds": [
      "20q13.33 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12864",
    "question": "What is associated with Necrotizing myopathy?",
    "seeds": [
      "Necrotizing myopathy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12865",
    "question": "What phenotype is associated with SPONDYLOEPIMETAPHYSEAL DYSPLASIA, MICROMELIC?",
    "seeds": [
      "SPONDYLOEPIMETAPHYSEAL DYSPLASIA, MICROMELIC"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12866",
    "question": "What is associated with Cephalohematoma?",
    "seeds": [
      "Cephalohematoma"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12867",
    "question": "What is associated with Abnormal calvaria morphology?",
    "seeds": [
      "Abnormal calvaria morphology"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12868",
    "question": "What is associated with Dermatosparaxis Ehlers-Danlos syndrome?",
    "seeds": [
      "Dermatosparaxis Ehlers-Danlos syndrome"
    ],
    "gold_answer": "Hernia of the abdominal wall",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12869",
    "question": "What is associated with Hamartomatous polyposis?",
    "seeds": [
      "Hamartomatous polyposis"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12870",
    "question": "What is associated with Isolated autosomal dominant hypomagnesemia, Glaudemans type?",
    "seeds": [
      "Isolated autosomal dominant hypomagnesemia, Glaudemans type"
    ],
    "gold_answer": "KCNA1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12871",
    "question": "What is associated with PALLIDAL DEGENERATION, PROGRESSIVE, WITH RETINITIS PIGMENTOSA?",
    "seeds": [
      "PALLIDAL DEGENERATION, PROGRESSIVE, WITH RETINITIS PIGMENTOSA"
    ],
    "gold_answer": "Abnormality of extrapyramidal motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12872",
    "question": "What phenotype is associated with Omodysplasia 2?",
    "seeds": [
      "Omodysplasia 2"
    ],
    "gold_answer": "Posteriorly rotated ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12873",
    "question": "What is associated with Kikuchi-Fujimoto disease?",
    "seeds": [
      "Kikuchi-Fujimoto disease"
    ],
    "gold_answer": "Abnormal salivary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12874",
    "question": "What is associated with Abnormality of skull size?",
    "seeds": [
      "Abnormality of skull size"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12875",
    "question": "What is associated with Short upper eyelashes?",
    "seeds": [
      "Short upper eyelashes"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12876",
    "question": "What is associated with Large pelvis bone?",
    "seeds": [
      "Large pelvis bone"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12877",
    "question": "What is associated with Penile freckling?",
    "seeds": [
      "Penile freckling"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12878",
    "question": "What phenotype is associated with Dermatosis papulosa nigra?",
    "seeds": [
      "Dermatosis papulosa nigra"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12879",
    "question": "What is associated with Focal autonomic seizure with pupillary dilation/constriction?",
    "seeds": [
      "Focal autonomic seizure with pupillary dilation/constriction"
    ],
    "gold_answer": "Non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12880",
    "question": "What phenotype is associated with Listeriosis?",
    "seeds": [
      "Listeriosis"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12881",
    "question": "What phenotype is associated with Mosaic trisomy 14 syndrome?",
    "seeds": [
      "Mosaic trisomy 14 syndrome"
    ],
    "gold_answer": "Microphthalmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12882",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 38?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 38"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12883",
    "question": "What is associated with Gamma-aminobutyric acid transaminase deficiency?",
    "seeds": [
      "Gamma-aminobutyric acid transaminase deficiency"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12884",
    "question": "What is associated with Follicular infundibulum tumor?",
    "seeds": [
      "Follicular infundibulum tumor"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12885",
    "question": "What is associated with Abnormal urine hexanoylglycine concentration?",
    "seeds": [
      "Abnormal urine hexanoylglycine concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12886",
    "question": "What is associated with Elevated circulating palmitoleylcarnitine concentration?",
    "seeds": [
      "Elevated circulating palmitoleylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12887",
    "question": "What is associated with Focal neonatal sequential seizure?",
    "seeds": [
      "Focal neonatal sequential seizure"
    ],
    "gold_answer": "Neonatal electro-clinical seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12888",
    "question": "What phenotype is associated with Ichthyosis, congenital, autosomal recessive 6?",
    "seeds": [
      "Ichthyosis, congenital, autosomal recessive 6"
    ],
    "gold_answer": "Corneal erosion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12889",
    "question": "What is associated with Decreased circulating acid maltase activity?",
    "seeds": [
      "Decreased circulating acid maltase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12890",
    "question": "What is associated with Abnormal ovarian physiology?",
    "seeds": [
      "Abnormal ovarian physiology"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12891",
    "question": "What is associated with Migraine without aura, susceptibility to, 4?",
    "seeds": [
      "Migraine without aura, susceptibility to, 4"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12892",
    "question": "What is associated with Short palpebral fissure?",
    "seeds": [
      "Short palpebral fissure"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12893",
    "question": "What is associated with Myasthenic syndrome, congenital, 5?",
    "seeds": [
      "Myasthenic syndrome, congenital, 5"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12894",
    "question": "What is associated with Unilateral ulnar hypoplasia?",
    "seeds": [
      "Unilateral ulnar hypoplasia"
    ],
    "gold_answer": "Short long bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12895",
    "question": "What is associated with Low-to-normal blood pressure?",
    "seeds": [
      "Low-to-normal blood pressure"
    ],
    "gold_answer": "Hypotension",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12896",
    "question": "What is associated with Increased circulating inhibin B concentration?",
    "seeds": [
      "Increased circulating inhibin B concentration"
    ],
    "gold_answer": "Abnormal circulating inhibin B concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12897",
    "question": "What is associated with Foveal hypoplasia and presenile cataract syndromefoveal hypoplasia, isolated, included?",
    "seeds": [
      "Foveal hypoplasia and presenile cataract syndromefoveal hypoplasia, isolated, included"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12898",
    "question": "What is associated with Facial edema?",
    "seeds": [
      "Facial edema"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12899",
    "question": "What is associated with Abnormal bronchus physiology?",
    "seeds": [
      "Abnormal bronchus physiology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12900",
    "question": "What is associated with Chromosome 8q22.1 duplication syndrome?",
    "seeds": [
      "Chromosome 8q22.1 duplication syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12901",
    "question": "What is associated with Coronary-pulmonary artery fistula?",
    "seeds": [
      "Coronary-pulmonary artery fistula"
    ],
    "gold_answer": "Coronary artery fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12902",
    "question": "What is associated with Microcephaly 11, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 11, primary, autosomal recessive"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12903",
    "question": "What is associated with Maternal uniparental disomy of chromosome X syndrome?",
    "seeds": [
      "Maternal uniparental disomy of chromosome X syndrome"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12904",
    "question": "What is associated with Type I cryptotia?",
    "seeds": [
      "Type I cryptotia"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12905",
    "question": "What is associated with Unaided visual acuity 3.0 LogMAR?",
    "seeds": [
      "Unaided visual acuity 3.0 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12906",
    "question": "What is associated with AV nodal tachycardia?",
    "seeds": [
      "AV nodal tachycardia"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12907",
    "question": "What is associated with Autoimmune hemolytic anemia?",
    "seeds": [
      "Autoimmune hemolytic anemia"
    ],
    "gold_answer": "Hemolytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12908",
    "question": "What is associated with Obliterative abnormality of the renal glomerulus?",
    "seeds": [
      "Obliterative abnormality of the renal glomerulus"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12909",
    "question": "What is associated with Decreased circulating vitamin C concentration?",
    "seeds": [
      "Decreased circulating vitamin C concentration"
    ],
    "gold_answer": "Abnormal metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12910",
    "question": "What is associated with Fragmentation of the epiphyses of the 3rd toe?",
    "seeds": [
      "Fragmentation of the epiphyses of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12911",
    "question": "What is associated with Abnormal experience of reality?",
    "seeds": [
      "Abnormal experience of reality"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12912",
    "question": "What is associated with Hypoplastic optic chiasm?",
    "seeds": [
      "Hypoplastic optic chiasm"
    ],
    "gold_answer": "Abnormal optic chiasm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12913",
    "question": "What is associated with Bleeding disorder in hemophilia B carriers?",
    "seeds": [
      "Bleeding disorder in hemophilia B carriers"
    ],
    "gold_answer": "F9",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12914",
    "question": "What is associated with Placoid macular lesion?",
    "seeds": [
      "Placoid macular lesion"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12915",
    "question": "What is associated with Morgagni-Stewart-Morel syndrome?",
    "seeds": [
      "Morgagni-Stewart-Morel syndrome"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12916",
    "question": "What is associated with Diamond-Blackfan anemia 8?",
    "seeds": [
      "Diamond-Blackfan anemia 8"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12917",
    "question": "What is associated with Mitochondrial DNA depletion syndrome, hepatocerebrorenal form?",
    "seeds": [
      "Mitochondrial DNA depletion syndrome, hepatocerebrorenal form"
    ],
    "gold_answer": "TWNK",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_12918",
    "question": "What is associated with Albinism, oculocutaneous, type V?",
    "seeds": [
      "Albinism, oculocutaneous, type V"
    ],
    "gold_answer": "Sensory behavioral abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12919",
    "question": "What is associated with Proximal upper limb muscle hypertrophy?",
    "seeds": [
      "Proximal upper limb muscle hypertrophy"
    ],
    "gold_answer": "Skeletal muscle hypertrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12920",
    "question": "What is associated with Curved fingers?",
    "seeds": [
      "Curved fingers"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12921",
    "question": "What is associated with Aplasia of the middle phalanx of the 4th toe?",
    "seeds": [
      "Aplasia of the middle phalanx of the 4th toe"
    ],
    "gold_answer": "Aplasia of the phalanges of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12922",
    "question": "What is associated with Cystathioninemia?",
    "seeds": [
      "Cystathioninemia"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12923",
    "question": "What is associated with Focal impaired awareness emotional seizure with pleasure?",
    "seeds": [
      "Focal impaired awareness emotional seizure with pleasure"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12924",
    "question": "What phenotype is associated with Chilblain lupus?",
    "seeds": [
      "Chilblain lupus"
    ],
    "gold_answer": "Chorea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12925",
    "question": "What is associated with Phocomelia?",
    "seeds": [
      "Phocomelia"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12926",
    "question": "What is associated with Congenital chronic diarrhea with protein-losing enteropathy?",
    "seeds": [
      "Congenital chronic diarrhea with protein-losing enteropathy"
    ],
    "gold_answer": "DGAT1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_12927",
    "question": "What is associated with Interlobular vein intima/media coagulative necrosis?",
    "seeds": [
      "Interlobular vein intima/media coagulative necrosis"
    ],
    "gold_answer": "Interlobular vein intima/media necrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12928",
    "question": "What is associated with Amyotrophic lateral sclerosis and/or frontotemporal dementia 1?",
    "seeds": [
      "Amyotrophic lateral sclerosis and/or frontotemporal dementia 1"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12929",
    "question": "What is associated with Arginine vasopressin deficiency?",
    "seeds": [
      "Arginine vasopressin deficiency"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12930",
    "question": "What is associated with Al-Gazali-Bakalinova syndrome?",
    "seeds": [
      "Al-Gazali-Bakalinova syndrome"
    ],
    "gold_answer": "Abnormality of mouth shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12931",
    "question": "What phenotype is associated with Colchicine poisoning?",
    "seeds": [
      "Colchicine poisoning"
    ],
    "gold_answer": "Alopecia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12932",
    "question": "What is associated with Intrauterine digital amputation?",
    "seeds": [
      "Intrauterine digital amputation"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12933",
    "question": "What is associated with Lichenification?",
    "seeds": [
      "Lichenification"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12934",
    "question": "What phenotype is associated with Dystonia 6, torsion?",
    "seeds": [
      "Dystonia 6, torsion"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12935",
    "question": "What is associated with Sleep-wake cycle disturbance?",
    "seeds": [
      "Sleep-wake cycle disturbance"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12936",
    "question": "What is associated with Reduced circulating insulin-like growth factor 2 concentration?",
    "seeds": [
      "Reduced circulating insulin-like growth factor 2 concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12937",
    "question": "What is associated with Nodular goiter?",
    "seeds": [
      "Nodular goiter"
    ],
    "gold_answer": "Goiter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12938",
    "question": "What is associated with Aplasia of the falx cerebri?",
    "seeds": [
      "Aplasia of the falx cerebri"
    ],
    "gold_answer": "Abnormality of the falx cerebri",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12939",
    "question": "What is associated with Methylmalonic aciduria and homocystinuria, Cblf type?",
    "seeds": [
      "Methylmalonic aciduria and homocystinuria, Cblf type"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12940",
    "question": "What is associated with Intellectual developmental disorder, X-linked 88?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 88"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12941",
    "question": "What phenotype is associated with Congenital nephrotic syndrome, Finnish type?",
    "seeds": [
      "Congenital nephrotic syndrome, Finnish type"
    ],
    "gold_answer": "Proteinuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12942",
    "question": "What is associated with Abnormal timing of light-adapted flicker electroretinogram?",
    "seeds": [
      "Abnormal timing of light-adapted flicker electroretinogram"
    ],
    "gold_answer": "Abnormal light-adapted flicker electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12943",
    "question": "What phenotype is associated with Neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination"
    ],
    "gold_answer": "Small for gestational age",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12944",
    "question": "What is associated with Spermatogenic failure 98?",
    "seeds": [
      "Spermatogenic failure 98"
    ],
    "gold_answer": "Decreased fertility in males",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12945",
    "question": "What is associated with Schwannomatosis 2?",
    "seeds": [
      "Schwannomatosis 2"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12946",
    "question": "What phenotype is associated with Carpal tunnel syndrome 2?",
    "seeds": [
      "Carpal tunnel syndrome 2"
    ],
    "gold_answer": "Hand paresthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12947",
    "question": "What is associated with Increased caudate lactate level?",
    "seeds": [
      "Increased caudate lactate level"
    ],
    "gold_answer": "Abnormal caudate nucleus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12948",
    "question": "What is associated with Reduced tissue phosphorylase kinase activity?",
    "seeds": [
      "Reduced tissue phosphorylase kinase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12949",
    "question": "What is associated with Abnormal ureter morphology?",
    "seeds": [
      "Abnormal ureter morphology"
    ],
    "gold_answer": "Abnormality of the ureter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12950",
    "question": "What is associated with Abnormal anus morphology?",
    "seeds": [
      "Abnormal anus morphology"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12951",
    "question": "What is associated with Episodic ataxia, type 5?",
    "seeds": [
      "Episodic ataxia, type 5"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12952",
    "question": "What phenotype is associated with Neurodevelopmental disorder with or without autism or seizures?",
    "seeds": [
      "Neurodevelopmental disorder with or without autism or seizures"
    ],
    "gold_answer": "Bifid uvula",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12953",
    "question": "What is associated with Abnormal left ventricular end-diastolic volume?",
    "seeds": [
      "Abnormal left ventricular end-diastolic volume"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12954",
    "question": "What is associated with Alaninuria?",
    "seeds": [
      "Alaninuria"
    ],
    "gold_answer": "Increased proteinogenic amino acid level in urine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12955",
    "question": "What is associated with Transient aminoaciduria?",
    "seeds": [
      "Transient aminoaciduria"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12956",
    "question": "What is associated with ENDOVE syndrome, limb-brain type?",
    "seeds": [
      "ENDOVE syndrome, limb-brain type"
    ],
    "gold_answer": "Abnormal abdominal wall morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12957",
    "question": "What is associated with Oral synechia?",
    "seeds": [
      "Oral synechia"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12958",
    "question": "What phenotype is associated with Spastic paraplegia 79, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 79, autosomal recessive"
    ],
    "gold_answer": "Loss of ambulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12959",
    "question": "What is associated with Hyperalaninemia?",
    "seeds": [
      "Hyperalaninemia"
    ],
    "gold_answer": "Abnormal circulating alanine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12960",
    "question": "What is associated with Anti-topoisomerase I antibody positivity?",
    "seeds": [
      "Anti-topoisomerase I antibody positivity"
    ],
    "gold_answer": "Antinuclear antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12961",
    "question": "What is associated with VISS syndrome?",
    "seeds": [
      "VISS syndrome"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12962",
    "question": "What phenotype is associated with Deafness, autosomal dominant 51?",
    "seeds": [
      "Deafness, autosomal dominant 51"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12963",
    "question": "What is associated with Oculocutaneous albinism type 1B?",
    "seeds": [
      "Oculocutaneous albinism type 1B"
    ],
    "gold_answer": "Abnormal iris pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12964",
    "question": "What phenotype is associated with Micro syndrome?",
    "seeds": [
      "Micro syndrome"
    ],
    "gold_answer": "Impaired smooth pursuit",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12965",
    "question": "What is associated with Unilateral oligodactyly?",
    "seeds": [
      "Unilateral oligodactyly"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12966",
    "question": "What is associated with Cholestasis, progressive familial intrahepatic, 3?",
    "seeds": [
      "Cholestasis, progressive familial intrahepatic, 3"
    ],
    "gold_answer": "Abnormal gamma-glutamyltransferase level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12967",
    "question": "What is associated with Supraauricular pit?",
    "seeds": [
      "Supraauricular pit"
    ],
    "gold_answer": "Periauricular skin pits",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12968",
    "question": "What is associated with Abnormality of the pulmonary vasculature?",
    "seeds": [
      "Abnormality of the pulmonary vasculature"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12969",
    "question": "What is associated with Trousseau sign?",
    "seeds": [
      "Trousseau sign"
    ],
    "gold_answer": "Muscle spasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12970",
    "question": "What is associated with Pulsatile liver?",
    "seeds": [
      "Pulsatile liver"
    ],
    "gold_answer": "Abnormal hepatobiliary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12971",
    "question": "What is associated with EEG with parietal epileptiform discharges?",
    "seeds": [
      "EEG with parietal epileptiform discharges"
    ],
    "gold_answer": "EEG with focal epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12972",
    "question": "What is associated with Increased circulating thyroglobulin concentration?",
    "seeds": [
      "Increased circulating thyroglobulin concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12973",
    "question": "What is associated with Hutterite cerebroosteonephrodysplasia syndrome?",
    "seeds": [
      "Hutterite cerebroosteonephrodysplasia syndrome"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12974",
    "question": "What is associated with Increased level of gamma-aminobutyric acid in urine?",
    "seeds": [
      "Increased level of gamma-aminobutyric acid in urine"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12975",
    "question": "What is associated with Mosaic trisomy 17 syndrome?",
    "seeds": [
      "Mosaic trisomy 17 syndrome"
    ],
    "gold_answer": "Abnormal ventricular septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12976",
    "question": "What is associated with Atelosteogenesis, type II?",
    "seeds": [
      "Atelosteogenesis, type II"
    ],
    "gold_answer": "Abnormal chondrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12977",
    "question": "What is associated with Objectification of others?",
    "seeds": [
      "Objectification of others"
    ],
    "gold_answer": "Abnormal social development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12978",
    "question": "What is associated with Juvenile posterior subcapsular lenticular opacities?",
    "seeds": [
      "Juvenile posterior subcapsular lenticular opacities"
    ],
    "gold_answer": "Posterior subcapsular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12979",
    "question": "What is associated with Triangular epiphysis of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Triangular epiphysis of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Triangular epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12980",
    "question": "What is associated with Abnormality of the nose?",
    "seeds": [
      "Abnormality of the nose"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12981",
    "question": "What phenotype is associated with Porokeratosis 6, disseminated superficial Actinic type?",
    "seeds": [
      "Porokeratosis 6, disseminated superficial Actinic type"
    ],
    "gold_answer": "Porokeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12982",
    "question": "What is associated with MUTYH-related polyposis?",
    "seeds": [
      "MUTYH-related polyposis"
    ],
    "gold_answer": "Abnormal rectum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12983",
    "question": "What is associated with Abnormality on pulmonary function testing?",
    "seeds": [
      "Abnormality on pulmonary function testing"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12984",
    "question": "What phenotype is associated with Developmental delay with variable intellectual disability and dysmorphic facies?",
    "seeds": [
      "Developmental delay with variable intellectual disability and dysmorphic facies"
    ],
    "gold_answer": "Retrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_12985",
    "question": "What is associated with Opportunistic viral infection?",
    "seeds": [
      "Opportunistic viral infection"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12986",
    "question": "What is associated with Bifid distal phalanx of the thumb?",
    "seeds": [
      "Bifid distal phalanx of the thumb"
    ],
    "gold_answer": "Duplication of the distal phalanx of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12987",
    "question": "What is associated with Brachycephaly, deafness, cataract, microstomia, and impaired intellectual development?",
    "seeds": [
      "Brachycephaly, deafness, cataract, microstomia, and impaired intellectual development"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12988",
    "question": "What is associated with Nonaka myopathy?",
    "seeds": [
      "Nonaka myopathy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12989",
    "question": "What is associated with Tibial spur?",
    "seeds": [
      "Tibial spur"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12990",
    "question": "What is associated with Abnormal circulating heparan sulfate level?",
    "seeds": [
      "Abnormal circulating heparan sulfate level"
    ],
    "gold_answer": "Abnormal circulating carbohydrate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12991",
    "question": "What is associated with Hypotrichosis 12?",
    "seeds": [
      "Hypotrichosis 12"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12992",
    "question": "What is associated with Upper limb mesomelic dysplasia, type Fryns?",
    "seeds": [
      "Upper limb mesomelic dysplasia, type Fryns"
    ],
    "gold_answer": "Abnormal shape of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12993",
    "question": "What is associated with Aplasia/Hypoplasia of the middle phalanges of the hand?",
    "seeds": [
      "Aplasia/Hypoplasia of the middle phalanges of the hand"
    ],
    "gold_answer": "Abnormal middle phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12994",
    "question": "What is associated with Restrictive behavior?",
    "seeds": [
      "Restrictive behavior"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12995",
    "question": "What is associated with Deafness, autosomal dominant 2B?",
    "seeds": [
      "Deafness, autosomal dominant 2B"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12996",
    "question": "What is associated with Slanting of the palpebral fissure?",
    "seeds": [
      "Slanting of the palpebral fissure"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12997",
    "question": "What is associated with Corneal dystrophy, fuchs endothelial, 6?",
    "seeds": [
      "Corneal dystrophy, fuchs endothelial, 6"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12998",
    "question": "What is associated with Abnormal ear physiology?",
    "seeds": [
      "Abnormal ear physiology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_12999",
    "question": "What is associated with Sanjad-Sakati syndrome?",
    "seeds": [
      "Sanjad-Sakati syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13000",
    "question": "What is associated with Thumb hypoplasia grade 2?",
    "seeds": [
      "Thumb hypoplasia grade 2"
    ],
    "gold_answer": "Short finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13001",
    "question": "What is associated with Salter I fracture?",
    "seeds": [
      "Salter I fracture"
    ],
    "gold_answer": "Physeal fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13002",
    "question": "What is associated with Basalioma of the outer ear?",
    "seeds": [
      "Basalioma of the outer ear"
    ],
    "gold_answer": "Neoplasm of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13003",
    "question": "What is associated with Neuropathy, hereditary sensory and autonomic, type V?",
    "seeds": [
      "Neuropathy, hereditary sensory and autonomic, type V"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13004",
    "question": "What is associated with Tubular microcystic change?",
    "seeds": [
      "Tubular microcystic change"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13005",
    "question": "What is associated with Dental ankylosis?",
    "seeds": [
      "Dental ankylosis"
    ],
    "gold_answer": "Deviation of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13006",
    "question": "What is associated with Mediastinal lymphadenopathy?",
    "seeds": [
      "Mediastinal lymphadenopathy"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13007",
    "question": "What is associated with Anti-carbonic anhydrase VI antibody positivity?",
    "seeds": [
      "Anti-carbonic anhydrase VI antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13008",
    "question": "What phenotype is associated with Chromosome xp11.3 deletion syndrome?",
    "seeds": [
      "Chromosome xp11.3 deletion syndrome"
    ],
    "gold_answer": "Horizontal nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13009",
    "question": "What is associated with Increased circulating pancreatic triacylglycerol lipase level?",
    "seeds": [
      "Increased circulating pancreatic triacylglycerol lipase level"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13010",
    "question": "What phenotype is associated with Ankyloblepharon filiforme adnatum and cleft palate?",
    "seeds": [
      "Ankyloblepharon filiforme adnatum and cleft palate"
    ],
    "gold_answer": "Cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13011",
    "question": "What is associated with Short proximal phalanx of hallux?",
    "seeds": [
      "Short proximal phalanx of hallux"
    ],
    "gold_answer": "Short phalanx of hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13012",
    "question": "What is associated with Recurrent patellar dislocation?",
    "seeds": [
      "Recurrent patellar dislocation"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13013",
    "question": "What is associated with Dystonia 13, torsion?",
    "seeds": [
      "Dystonia 13, torsion"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13014",
    "question": "What is associated with Premature ejaculation?",
    "seeds": [
      "Premature ejaculation"
    ],
    "gold_answer": "Abnormal ejaculation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13015",
    "question": "What is associated with Patellar subluxation?",
    "seeds": [
      "Patellar subluxation"
    ],
    "gold_answer": "Abnormal knee morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13016",
    "question": "What phenotype is associated with Bornholm eye disease?",
    "seeds": [
      "Bornholm eye disease"
    ],
    "gold_answer": "Astigmatism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13017",
    "question": "What is associated with Pulsatile tinnitus?",
    "seeds": [
      "Pulsatile tinnitus"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13018",
    "question": "What is associated with Aortic root aneurysm?",
    "seeds": [
      "Aortic root aneurysm"
    ],
    "gold_answer": "Thoracic aortic aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13019",
    "question": "What is associated with Carotid artery tortuosity?",
    "seeds": [
      "Carotid artery tortuosity"
    ],
    "gold_answer": "Arterial tortuosity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13020",
    "question": "What phenotype is associated with Lymphatic malformation 9?",
    "seeds": [
      "Lymphatic malformation 9"
    ],
    "gold_answer": "Tortuous lymphatic vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13021",
    "question": "What is associated with ENDOCRINE-CEREBROOSTEODYSPLASIA?",
    "seeds": [
      "ENDOCRINE-CEREBROOSTEODYSPLASIA"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13022",
    "question": "What is associated with Increased circulating interleukin 1beta concentration?",
    "seeds": [
      "Increased circulating interleukin 1beta concentration"
    ],
    "gold_answer": "Abnormal circulating cytokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13023",
    "question": "What is associated with Rest dyspnea?",
    "seeds": [
      "Rest dyspnea"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13024",
    "question": "What is associated with Corneal iron line?",
    "seeds": [
      "Corneal iron line"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13025",
    "question": "What is associated with Patchy sclerosis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Patchy sclerosis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13026",
    "question": "What is associated with Spermatogenic failure 31?",
    "seeds": [
      "Spermatogenic failure 31"
    ],
    "gold_answer": "Infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13027",
    "question": "What is associated with Myelodysplastic neoplasm with increased blasts type 1?",
    "seeds": [
      "Myelodysplastic neoplasm with increased blasts type 1"
    ],
    "gold_answer": "TET2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13028",
    "question": "What is associated with Lateral meningocele syndrome?",
    "seeds": [
      "Lateral meningocele syndrome"
    ],
    "gold_answer": "Hemiplegia/hemiparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13029",
    "question": "What is associated with Aphalangy of the hands?",
    "seeds": [
      "Aphalangy of the hands"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13030",
    "question": "What is associated with Deafness, autosomal recessive 122?",
    "seeds": [
      "Deafness, autosomal recessive 122"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13031",
    "question": "What is associated with Prelingual sensorineural hearing impairment?",
    "seeds": [
      "Prelingual sensorineural hearing impairment"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13032",
    "question": "What is associated with Aplasia/Hypoplasia involving the skeletal musculature?",
    "seeds": [
      "Aplasia/Hypoplasia involving the skeletal musculature"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13033",
    "question": "What is associated with Nystagmus 4, congenital, autosomal dominant?",
    "seeds": [
      "Nystagmus 4, congenital, autosomal dominant"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13034",
    "question": "What is associated with Irregular tarsal bones?",
    "seeds": [
      "Irregular tarsal bones"
    ],
    "gold_answer": "Abnormality of the tarsal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13035",
    "question": "What is associated with Short phalanx of the 5th toe?",
    "seeds": [
      "Short phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13036",
    "question": "What is associated with Thick growth plates?",
    "seeds": [
      "Thick growth plates"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13037",
    "question": "What is associated with Dilatation of the tricuspid annulus?",
    "seeds": [
      "Dilatation of the tricuspid annulus"
    ],
    "gold_answer": "Abnormal tricuspid valve annulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13038",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked, syndromic 32?",
    "seeds": [
      "Intellectual developmental disorder, X-linked, syndromic 32"
    ],
    "gold_answer": "Absent speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13039",
    "question": "What is associated with Familial isolated café-au-lait macules?",
    "seeds": [
      "Familial isolated café-au-lait macules"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13040",
    "question": "What is associated with Hypocalcification of dental enamel?",
    "seeds": [
      "Hypocalcification of dental enamel"
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13041",
    "question": "What is associated with Absent epiphysis of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Absent epiphysis of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Absent epiphyses of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13042",
    "question": "What is associated with Abnormality of the tarsal bones?",
    "seeds": [
      "Abnormality of the tarsal bones"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13043",
    "question": "What is associated with Retinitis pigmentosa 77?",
    "seeds": [
      "Retinitis pigmentosa 77"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13044",
    "question": "What is associated with 1-4 toe syndactyly?",
    "seeds": [
      "1-4 toe syndactyly"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13045",
    "question": "What is associated with Multifocal seizures?",
    "seeds": [
      "Multifocal seizures"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13046",
    "question": "What phenotype is associated with Multiple tumor-associated chromosome region 1?",
    "seeds": [
      "Multiple tumor-associated chromosome region 1"
    ],
    "gold_answer": "Nephroblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13047",
    "question": "What phenotype is associated with Amelogenesis imperfecta?",
    "seeds": [
      "Amelogenesis imperfecta"
    ],
    "gold_answer": "Taurodontia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13048",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 103?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 103"
    ],
    "gold_answer": "Coarse facial features",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13049",
    "question": "What is associated with Vitamin B12-unresponsive methylmalonic acidemia type mut0?",
    "seeds": [
      "Vitamin B12-unresponsive methylmalonic acidemia type mut0"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13050",
    "question": "What is associated with Elevated circulating DNAJB9 protein concentration?",
    "seeds": [
      "Elevated circulating DNAJB9 protein concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13051",
    "question": "What phenotype is associated with Multiple mitochondrial dysfunctions syndrome 10?",
    "seeds": [
      "Multiple mitochondrial dysfunctions syndrome 10"
    ],
    "gold_answer": "Barrett esophagus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13052",
    "question": "What is associated with Increased peripheral myelin thickness?",
    "seeds": [
      "Increased peripheral myelin thickness"
    ],
    "gold_answer": "Peripheral hypermyelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13053",
    "question": "What is associated with Intermittent hydrarthrosis?",
    "seeds": [
      "Intermittent hydrarthrosis"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13054",
    "question": "What is associated with Congenital disorder of glycosylation, type Il?",
    "seeds": [
      "Congenital disorder of glycosylation, type Il"
    ],
    "gold_answer": "Abnormal nasal bridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13055",
    "question": "What is associated with Proximal to distal progression?",
    "seeds": [
      "Proximal to distal progression"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13056",
    "question": "What is associated with Intermittent hyperventilation?",
    "seeds": [
      "Intermittent hyperventilation"
    ],
    "gold_answer": "Hyperventilation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13057",
    "question": "What is associated with Septic pulmonary embolism?",
    "seeds": [
      "Septic pulmonary embolism"
    ],
    "gold_answer": "Thromboembolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13058",
    "question": "What is associated with Fibrosis of extraocular muscles, congenital, with synergistic divergence?",
    "seeds": [
      "Fibrosis of extraocular muscles, congenital, with synergistic divergence"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13059",
    "question": "What is associated with Oocyte maturation defect 5?",
    "seeds": [
      "Oocyte maturation defect 5"
    ],
    "gold_answer": "Abnormal meiosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13060",
    "question": "What is associated with Abnormal nasal morphology?",
    "seeds": [
      "Abnormal nasal morphology"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13061",
    "question": "What is associated with Mesangial fibrillary deposits?",
    "seeds": [
      "Mesangial fibrillary deposits"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13062",
    "question": "What phenotype is associated with Epilepsy, progressive myoclonic, 4, with or without renal failure?",
    "seeds": [
      "Epilepsy, progressive myoclonic, 4, with or without renal failure"
    ],
    "gold_answer": "Proteinuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13063",
    "question": "What is associated with Primary lateral sclerosis?",
    "seeds": [
      "Primary lateral sclerosis"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13064",
    "question": "What is associated with Intratubular vancomycin casts?",
    "seeds": [
      "Intratubular vancomycin casts"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13065",
    "question": "What is associated with Indeterminate ventricular axis?",
    "seeds": [
      "Indeterminate ventricular axis"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13066",
    "question": "What is associated with Ciliary dyskinesia, primary, 12?",
    "seeds": [
      "Ciliary dyskinesia, primary, 12"
    ],
    "gold_answer": "CITED2",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_13067",
    "question": "What is associated with Moderate receptive language delay?",
    "seeds": [
      "Moderate receptive language delay"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13068",
    "question": "What phenotype is associated with Retinitis pigmentosa 2, X-linked?",
    "seeds": [
      "Retinitis pigmentosa 2, X-linked"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13069",
    "question": "What is associated with Chronic hiccup?",
    "seeds": [
      "Chronic hiccup"
    ],
    "gold_answer": "Abnormal emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13070",
    "question": "What is associated with Aplasia of the fallopian tube?",
    "seeds": [
      "Aplasia of the fallopian tube"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the fallopian tube",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13071",
    "question": "What is associated with Distal radioulnar joint space widening?",
    "seeds": [
      "Distal radioulnar joint space widening"
    ],
    "gold_answer": "Abnormal forearm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13072",
    "question": "What is associated with Lid lag on downgaze?",
    "seeds": [
      "Lid lag on downgaze"
    ],
    "gold_answer": "Abnormal ocular adnexa physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13073",
    "question": "What is associated with Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome?",
    "seeds": [
      "Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13074",
    "question": "What is associated with Multiple mitochondrial dysfunctions syndrome 4?",
    "seeds": [
      "Multiple mitochondrial dysfunctions syndrome 4"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13075",
    "question": "What is associated with Focal impaired awareness sensory seizure with cephalic sensation?",
    "seeds": [
      "Focal impaired awareness sensory seizure with cephalic sensation"
    ],
    "gold_answer": "Focal impaired awareness non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13076",
    "question": "What is associated with Cervical vertebral bridge?",
    "seeds": [
      "Cervical vertebral bridge"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13077",
    "question": "What is associated with Medullary thyroid carcinoma?",
    "seeds": [
      "Medullary thyroid carcinoma"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13078",
    "question": "What is associated with Homocystinuria, B6-responsive and nonresponsive types?",
    "seeds": [
      "Homocystinuria, B6-responsive and nonresponsive types"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13079",
    "question": "What is associated with Abnormality of the epiphysis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Abnormality of the epiphysis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13080",
    "question": "What is associated with Böök syndrome?",
    "seeds": [
      "Böök syndrome"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13081",
    "question": "What is associated with Straddling atrioventricular valve?",
    "seeds": [
      "Straddling atrioventricular valve"
    ],
    "gold_answer": "Abnormal connection of the cardiac segments",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13082",
    "question": "What is associated with Anti-phospholipase A2 receptor antibody positivity?",
    "seeds": [
      "Anti-phospholipase A2 receptor antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13083",
    "question": "What phenotype is associated with Hypospadias 1, X-linked?",
    "seeds": [
      "Hypospadias 1, X-linked"
    ],
    "gold_answer": "Perineal hypospadias",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13084",
    "question": "What is associated with Myoclonic epilepsy, juvenile, susceptibility to, 4?",
    "seeds": [
      "Myoclonic epilepsy, juvenile, susceptibility to, 4"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13085",
    "question": "What is associated with Hypolysinemia?",
    "seeds": [
      "Hypolysinemia"
    ],
    "gold_answer": "Abnormal circulating lysine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13086",
    "question": "What is associated with Anti-HLA-DQ antibody positivity?",
    "seeds": [
      "Anti-HLA-DQ antibody positivity"
    ],
    "gold_answer": "Anti-HLA antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13087",
    "question": "What is associated with Gnathodiaphyseal dysplasia?",
    "seeds": [
      "Gnathodiaphyseal dysplasia"
    ],
    "gold_answer": "Reduced bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13088",
    "question": "What is associated with Chiari type II malformation?",
    "seeds": [
      "Chiari type II malformation"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13089",
    "question": "What is associated with Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13090",
    "question": "What is associated with Umbilical vein varix?",
    "seeds": [
      "Umbilical vein varix"
    ],
    "gold_answer": "Abnormality of the umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13091",
    "question": "What phenotype is associated with Neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures?",
    "seeds": [
      "Neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures"
    ],
    "gold_answer": "Urinary incontinence",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13092",
    "question": "What is associated with Oral mucosal papule?",
    "seeds": [
      "Oral mucosal papule"
    ],
    "gold_answer": "Abnormal cheek morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13093",
    "question": "What is associated with Palatopharyngeal incompetence?",
    "seeds": [
      "Palatopharyngeal incompetence"
    ],
    "gold_answer": "Craniofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13094",
    "question": "What is associated with Developmental and epileptic encephalopathy 118?",
    "seeds": [
      "Developmental and epileptic encephalopathy 118"
    ],
    "gold_answer": "Abnormal saccadic eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13095",
    "question": "What is associated with Abnormal circulating asparagine concentration?",
    "seeds": [
      "Abnormal circulating asparagine concentration"
    ],
    "gold_answer": "Abnormal circulating aspartate family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13096",
    "question": "What is associated with Macular degeneration, age-related, 11?",
    "seeds": [
      "Macular degeneration, age-related, 11"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13097",
    "question": "What is associated with Ring chromosome Y syndrome?",
    "seeds": [
      "Ring chromosome Y syndrome"
    ],
    "gold_answer": "Abnormality of the lower urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13098",
    "question": "What is associated with Abnormality of pattern visual evoked potentials?",
    "seeds": [
      "Abnormality of pattern visual evoked potentials"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13099",
    "question": "What is associated with Medullary peritubular capillaritis?",
    "seeds": [
      "Medullary peritubular capillaritis"
    ],
    "gold_answer": "Abnormal peritubular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13100",
    "question": "What is associated with Hypomanganesemia?",
    "seeds": [
      "Hypomanganesemia"
    ],
    "gold_answer": "Abnormal blood inorganic cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13101",
    "question": "What is associated with Marbach-Schaaf neurodevelopmental syndrome?",
    "seeds": [
      "Marbach-Schaaf neurodevelopmental syndrome"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13102",
    "question": "What is associated with Familial cerebral saccular aneurysm?",
    "seeds": [
      "Familial cerebral saccular aneurysm"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13103",
    "question": "What is associated with Abnormal synovial membrane morphology?",
    "seeds": [
      "Abnormal synovial membrane morphology"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13104",
    "question": "What is associated with Paralytic ileus?",
    "seeds": [
      "Paralytic ileus"
    ],
    "gold_answer": "Ileus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13105",
    "question": "What is associated with Overmodelled hand bones?",
    "seeds": [
      "Overmodelled hand bones"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13106",
    "question": "What is associated with Abnormal brain lactate level by MRS?",
    "seeds": [
      "Abnormal brain lactate level by MRS"
    ],
    "gold_answer": "Abnormal metabolic brain imaging by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13107",
    "question": "What is associated with Emotional hypersensitivity?",
    "seeds": [
      "Emotional hypersensitivity"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13108",
    "question": "What is associated with Dark urine?",
    "seeds": [
      "Dark urine"
    ],
    "gold_answer": "Abnormal urinary color",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13109",
    "question": "What is associated with Limited knee flexion/extension?",
    "seeds": [
      "Limited knee flexion/extension"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13110",
    "question": "What is associated with Elevated erythrocyte adenosine triphosphate concentration?",
    "seeds": [
      "Elevated erythrocyte adenosine triphosphate concentration"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13111",
    "question": "What is associated with Focal segmental glomerulosclerosis 1?",
    "seeds": [
      "Focal segmental glomerulosclerosis 1"
    ],
    "gold_answer": "Abnormal renal echogenicity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13112",
    "question": "What phenotype is associated with RECON progeroid syndrome?",
    "seeds": [
      "RECON progeroid syndrome"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13113",
    "question": "What is associated with Primary progressive freezing gait?",
    "seeds": [
      "Primary progressive freezing gait"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13114",
    "question": "What is associated with Parkinson disease 22, autosomal dominant?",
    "seeds": [
      "Parkinson disease 22, autosomal dominant"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13115",
    "question": "What phenotype is associated with Protoporphyria, erythropoietic, 2?",
    "seeds": [
      "Protoporphyria, erythropoietic, 2"
    ],
    "gold_answer": "Iron deficiency anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13116",
    "question": "What is associated with Hypotelorism?",
    "seeds": [
      "Hypotelorism"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13117",
    "question": "What is associated with Macrothrombocytopenia, autosomal dominant, tubb1-related?",
    "seeds": [
      "Macrothrombocytopenia, autosomal dominant, tubb1-related"
    ],
    "gold_answer": "Abnormal platelet volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13118",
    "question": "What is associated with T-B+ severe combined immunodeficiency due to gamma chain deficiency?",
    "seeds": [
      "T-B+ severe combined immunodeficiency due to gamma chain deficiency"
    ],
    "gold_answer": "Abnormal urine cytology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13119",
    "question": "What is associated with Autosomal dominant mitochondrial myopathy with exercise intolerance?",
    "seeds": [
      "Autosomal dominant mitochondrial myopathy with exercise intolerance"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13120",
    "question": "What is associated with Paracentral?",
    "seeds": [
      "Paracentral"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13121",
    "question": "What is associated with Lymph-node follicular sclerosis?",
    "seeds": [
      "Lymph-node follicular sclerosis"
    ],
    "gold_answer": "Abnormal lymph-node tissue architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13122",
    "question": "What is associated with Deafness, neurosensory, autosomal recessive 42?",
    "seeds": [
      "Deafness, neurosensory, autosomal recessive 42"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13123",
    "question": "What is associated with Cockayne syndrome type 2?",
    "seeds": [
      "Cockayne syndrome type 2"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13124",
    "question": "What is associated with Hypochondriac delusion?",
    "seeds": [
      "Hypochondriac delusion"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13125",
    "question": "What is associated with Heart and brain malformation syndrome?",
    "seeds": [
      "Heart and brain malformation syndrome"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13126",
    "question": "What is associated with Refractory?",
    "seeds": [
      "Refractory"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13127",
    "question": "What is associated with 11 pairs of ribs?",
    "seeds": [
      "11 pairs of ribs"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13128",
    "question": "What is associated with Long upper lip?",
    "seeds": [
      "Long upper lip"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13129",
    "question": "What is associated with Hypoplasia of the iris?",
    "seeds": [
      "Hypoplasia of the iris"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the iris",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13130",
    "question": "What is associated with Flared distal fibular metaphysis?",
    "seeds": [
      "Flared distal fibular metaphysis"
    ],
    "gold_answer": "Flared metaphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13131",
    "question": "What is associated with Complete duplication of the phalanges of the 2nd finger?",
    "seeds": [
      "Complete duplication of the phalanges of the 2nd finger"
    ],
    "gold_answer": "Duplication of phalanx of 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13132",
    "question": "What is associated with Low placental alkaline phosphatase?",
    "seeds": [
      "Low placental alkaline phosphatase"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13133",
    "question": "What phenotype is associated with Neurodevelopmental disorder with behavioral, ear, and skeletal abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with behavioral, ear, and skeletal abnormalities"
    ],
    "gold_answer": "Tapered finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13134",
    "question": "What is associated with Facial telangiectasia in butterfly midface distribution?",
    "seeds": [
      "Facial telangiectasia in butterfly midface distribution"
    ],
    "gold_answer": "Telangiectasia of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13135",
    "question": "What is associated with Abnormal ventriculoarterial connection?",
    "seeds": [
      "Abnormal ventriculoarterial connection"
    ],
    "gold_answer": "Abnormal connection of the cardiac segments",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13136",
    "question": "What is associated with Pinguecula?",
    "seeds": [
      "Pinguecula"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13137",
    "question": "What phenotype is associated with Gastroschisisabdominal wall defects, included?",
    "seeds": [
      "Gastroschisisabdominal wall defects, included"
    ],
    "gold_answer": "Gastroschisis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13138",
    "question": "What is associated with Absent circulating immunoglobulin kappa chain?",
    "seeds": [
      "Absent circulating immunoglobulin kappa chain"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13139",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 72?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 72"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13140",
    "question": "What is associated with STXBP1-related encephalopathy?",
    "seeds": [
      "STXBP1-related encephalopathy"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13141",
    "question": "What is associated with Acrocephalopolydactyly?",
    "seeds": [
      "Acrocephalopolydactyly"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13142",
    "question": "What is associated with Aortic dissection?",
    "seeds": [
      "Aortic dissection"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13143",
    "question": "What is associated with Broad phalanx?",
    "seeds": [
      "Broad phalanx"
    ],
    "gold_answer": "Broad long bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13144",
    "question": "What is associated with Rothmund-Thomson syndrome type 1?",
    "seeds": [
      "Rothmund-Thomson syndrome type 1"
    ],
    "gold_answer": "Abnormal eyelash morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13145",
    "question": "What is associated with Hypoplasia of lymphatic vessels?",
    "seeds": [
      "Hypoplasia of lymphatic vessels"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13146",
    "question": "What is associated with Insect allergy?",
    "seeds": [
      "Insect allergy"
    ],
    "gold_answer": "Immunologic hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13147",
    "question": "What is associated with Ring chromosome 22 syndrome?",
    "seeds": [
      "Ring chromosome 22 syndrome"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13148",
    "question": "What is associated with Portal hypertension?",
    "seeds": [
      "Portal hypertension"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13149",
    "question": "What is associated with Brachydactyly, type A1, D?",
    "seeds": [
      "Brachydactyly, type A1, D"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13150",
    "question": "What is associated with Broad middle phalanx of the 2nd finger?",
    "seeds": [
      "Broad middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Broad middle phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13151",
    "question": "What is associated with Sensorineural deafness with dilated cardiomyopathy?",
    "seeds": [
      "Sensorineural deafness with dilated cardiomyopathy"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13152",
    "question": "What is associated with Parkinson disease 23, autosomal recessive, early onset?",
    "seeds": [
      "Parkinson disease 23, autosomal recessive, early onset"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13153",
    "question": "What is associated with Fractured middle phalanx of manual digit 3?",
    "seeds": [
      "Fractured middle phalanx of manual digit 3"
    ],
    "gold_answer": "Fractured finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13154",
    "question": "What is associated with Bronchial diverticula?",
    "seeds": [
      "Bronchial diverticula"
    ],
    "gold_answer": "Abnormal bronchus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13155",
    "question": "What phenotype is associated with L-2-hydroxyglutaric aciduria?",
    "seeds": [
      "L-2-hydroxyglutaric aciduria"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13156",
    "question": "What is associated with Hemolytic uremic syndrome, atypical, susceptibility to, 1?",
    "seeds": [
      "Hemolytic uremic syndrome, atypical, susceptibility to, 1"
    ],
    "gold_answer": "Reduced consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13157",
    "question": "What is associated with Myopathy, distal, 7, adult-onset, X-linked?",
    "seeds": [
      "Myopathy, distal, 7, adult-onset, X-linked"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13158",
    "question": "What is associated with Ocular dyssynergia?",
    "seeds": [
      "Ocular dyssynergia"
    ],
    "gold_answer": "Dyssynergia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13159",
    "question": "What is associated with Depression?",
    "seeds": [
      "Depression"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13160",
    "question": "What is associated with Increased proteinogenic amino acid level in urine?",
    "seeds": [
      "Increased proteinogenic amino acid level in urine"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13161",
    "question": "What is associated with Abnormal ureter morphology?",
    "seeds": [
      "Abnormal ureter morphology"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13162",
    "question": "What is associated with Brain small vessel disease 2B, autosomal recessive?",
    "seeds": [
      "Brain small vessel disease 2B, autosomal recessive"
    ],
    "gold_answer": "Stroke",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13163",
    "question": "What is associated with LAMA5-related multisystemic syndrome?",
    "seeds": [
      "LAMA5-related multisystemic syndrome"
    ],
    "gold_answer": "LAMA5",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13164",
    "question": "What is associated with Congenital shortened small intestine?",
    "seeds": [
      "Congenital shortened small intestine"
    ],
    "gold_answer": "Abnormal small intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13165",
    "question": "What is associated with Abnormal radial metaphysis morphology?",
    "seeds": [
      "Abnormal radial metaphysis morphology"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13166",
    "question": "What is associated with Increased blood drug concentration?",
    "seeds": [
      "Increased blood drug concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13167",
    "question": "What is associated with Increased OCT-measured macular thickness?",
    "seeds": [
      "Increased OCT-measured macular thickness"
    ],
    "gold_answer": "Abnormal optical coherence tomography",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13168",
    "question": "What is associated with 3-methylglutaconic aciduria, type IX?",
    "seeds": [
      "3-methylglutaconic aciduria, type IX"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13169",
    "question": "What is associated with Polycystic kidney disease 5?",
    "seeds": [
      "Polycystic kidney disease 5"
    ],
    "gold_answer": "Abnormal renal cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13170",
    "question": "What is associated with Dorsal subluxation of ulna?",
    "seeds": [
      "Dorsal subluxation of ulna"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13171",
    "question": "What is associated with Delusional atmosphere?",
    "seeds": [
      "Delusional atmosphere"
    ],
    "gold_answer": "Abnormal cognitive process",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13172",
    "question": "What is associated with Erythematous plaque?",
    "seeds": [
      "Erythematous plaque"
    ],
    "gold_answer": "Skin plaque",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13173",
    "question": "What is associated with Abnormal immune serum protein physiology?",
    "seeds": [
      "Abnormal immune serum protein physiology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13174",
    "question": "What is associated with Small intestinal polyp?",
    "seeds": [
      "Small intestinal polyp"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13175",
    "question": "What is associated with Cockayne syndrome type 3?",
    "seeds": [
      "Cockayne syndrome type 3"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13176",
    "question": "What is associated with Intellectual developmental disorder, X-linked syndromic 12?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic 12"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13177",
    "question": "What is associated with Abnormality of the submandibular region?",
    "seeds": [
      "Abnormality of the submandibular region"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13178",
    "question": "What is associated with Tylosis with esophageal cancer?",
    "seeds": [
      "Tylosis with esophageal cancer"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13179",
    "question": "What phenotype is associated with Arterial tortuosity syndrome?",
    "seeds": [
      "Arterial tortuosity syndrome"
    ],
    "gold_answer": "Macrotia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13180",
    "question": "What is associated with Best corrected visual acuity 1.1 LogMAR?",
    "seeds": [
      "Best corrected visual acuity 1.1 LogMAR"
    ],
    "gold_answer": "Abnormal best corrected visual acuity test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13181",
    "question": "What phenotype is associated with Ventriculomegaly with defects of the radius and kidney?",
    "seeds": [
      "Ventriculomegaly with defects of the radius and kidney"
    ],
    "gold_answer": "Ventricular septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13182",
    "question": "What is associated with Esodeviation?",
    "seeds": [
      "Esodeviation"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13183",
    "question": "What is associated with Aplasia/hypoplasia of proximal toe phalanx?",
    "seeds": [
      "Aplasia/hypoplasia of proximal toe phalanx"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13184",
    "question": "What is associated with Atypical absence status epilepticus?",
    "seeds": [
      "Atypical absence status epilepticus"
    ],
    "gold_answer": "Generalized non-convulsive status epilepticus without coma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13185",
    "question": "What is associated with Membranous nephropathy?",
    "seeds": [
      "Membranous nephropathy"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13186",
    "question": "What is associated with Simple renal cyst?",
    "seeds": [
      "Simple renal cyst"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13187",
    "question": "What is associated with Aortic aneurysm, abdominal?",
    "seeds": [
      "Aortic aneurysm, abdominal"
    ],
    "gold_answer": "Aortic aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13188",
    "question": "What is associated with Oculomotor synkinesis?",
    "seeds": [
      "Oculomotor synkinesis"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13189",
    "question": "What phenotype is associated with Cholestasis, progressive familial intrahepatic, 8?",
    "seeds": [
      "Cholestasis, progressive familial intrahepatic, 8"
    ],
    "gold_answer": "Elevated circulating alkaline phosphatase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13190",
    "question": "What is associated with Excessive cerumen?",
    "seeds": [
      "Excessive cerumen"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13191",
    "question": "What is associated with Malignant eosinophil proliferation?",
    "seeds": [
      "Malignant eosinophil proliferation"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13192",
    "question": "What is associated with Agenesis of second permanent molar?",
    "seeds": [
      "Agenesis of second permanent molar"
    ],
    "gold_answer": "Agenesis of permanent molar",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13193",
    "question": "What is associated with Well-differentiated liposarcoma?",
    "seeds": [
      "Well-differentiated liposarcoma"
    ],
    "gold_answer": "HMGA2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "role_in_the_phenotype_of"
    }
  },
  {
    "query_id": "orph_train_13194",
    "question": "What is associated with Cone-shaped metacarpal epiphyses?",
    "seeds": [
      "Cone-shaped metacarpal epiphyses"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13195",
    "question": "What is associated with Diminished tissue glycogen branching enzyme activity?",
    "seeds": [
      "Diminished tissue glycogen branching enzyme activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13196",
    "question": "What is associated with Fractured carpal bone?",
    "seeds": [
      "Fractured carpal bone"
    ],
    "gold_answer": "Abnormal wrist morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13197",
    "question": "What is associated with Fragmentation of the epiphysis of the distal phalanx of the hallux?",
    "seeds": [
      "Fragmentation of the epiphysis of the distal phalanx of the hallux"
    ],
    "gold_answer": "Abnormality of the epiphyses of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13198",
    "question": "What is associated with Abnormal gonadotropin-releasing hormone concentration?",
    "seeds": [
      "Abnormal gonadotropin-releasing hormone concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13199",
    "question": "What is associated with Ph-positive acute lymphoblastic leukemia?",
    "seeds": [
      "Ph-positive acute lymphoblastic leukemia"
    ],
    "gold_answer": "Leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13200",
    "question": "What is associated with Lower eyelid coloboma?",
    "seeds": [
      "Lower eyelid coloboma"
    ],
    "gold_answer": "Eyelid coloboma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13201",
    "question": "What is associated with Fanconi anemia, complementation group I?",
    "seeds": [
      "Fanconi anemia, complementation group I"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13202",
    "question": "What is associated with Deafness, autosomal dominant nonsyndromic sensorineural 11?",
    "seeds": [
      "Deafness, autosomal dominant nonsyndromic sensorineural 11"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13203",
    "question": "What is associated with Dysmetric saccades?",
    "seeds": [
      "Dysmetric saccades"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13204",
    "question": "What is associated with Pulmonary hypertension, primary, autosomal recessive?",
    "seeds": [
      "Pulmonary hypertension, primary, autosomal recessive"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13205",
    "question": "What phenotype is associated with Myopathy, granulovacuolar lobular, with electrical myotonia?",
    "seeds": [
      "Myopathy, granulovacuolar lobular, with electrical myotonia"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13206",
    "question": "What is associated with Hydrocephaly-low insertion umbilicus syndrome?",
    "seeds": [
      "Hydrocephaly-low insertion umbilicus syndrome"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13207",
    "question": "What is associated with Sporadic infantile bilateral striatal necrosis?",
    "seeds": [
      "Sporadic infantile bilateral striatal necrosis"
    ],
    "gold_answer": "Tube feeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13208",
    "question": "What is associated with Abnormal QRS complex?",
    "seeds": [
      "Abnormal QRS complex"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13209",
    "question": "What is associated with Abnormality of the diaphragm?",
    "seeds": [
      "Abnormality of the diaphragm"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13210",
    "question": "What is associated with Gingivitis?",
    "seeds": [
      "Gingivitis"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13211",
    "question": "What is associated with Malignant atrophic papulosis?",
    "seeds": [
      "Malignant atrophic papulosis"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13212",
    "question": "What is associated with Hypomyelination-congenital cataract syndrome?",
    "seeds": [
      "Hypomyelination-congenital cataract syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13213",
    "question": "What is associated with Abnormal pulmonary vein morphology?",
    "seeds": [
      "Abnormal pulmonary vein morphology"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13214",
    "question": "What is associated with Syndromic recessive X-linked ichthyosis?",
    "seeds": [
      "Syndromic recessive X-linked ichthyosis"
    ],
    "gold_answer": "Hematological neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13215",
    "question": "What is associated with Decreased sweating due to autonomic dysfunction?",
    "seeds": [
      "Decreased sweating due to autonomic dysfunction"
    ],
    "gold_answer": "Hypohidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13216",
    "question": "What is associated with Autosomal recessive ataxia, Beauce type?",
    "seeds": [
      "Autosomal recessive ataxia, Beauce type"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13217",
    "question": "What is associated with Derealization?",
    "seeds": [
      "Derealization"
    ],
    "gold_answer": "Abnormal interpretation of external stimuli",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13218",
    "question": "What phenotype is associated with Atrial septal defect 9?",
    "seeds": [
      "Atrial septal defect 9"
    ],
    "gold_answer": "Secundum atrial septal defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13219",
    "question": "What is associated with Irregular epiphysis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Irregular epiphysis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Irregular epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13220",
    "question": "What is associated with Sex reversal?",
    "seeds": [
      "Sex reversal"
    ],
    "gold_answer": "Abnormal sex determination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13221",
    "question": "What phenotype is associated with Dementia, lewy body?",
    "seeds": [
      "Dementia, lewy body"
    ],
    "gold_answer": "Fluctuations in consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13222",
    "question": "What is associated with DPM1-CDG?",
    "seeds": [
      "DPM1-CDG"
    ],
    "gold_answer": "Generalized non-motor (absence) seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13223",
    "question": "What is associated with Mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly?",
    "seeds": [
      "Mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the skull",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13224",
    "question": "What is associated with Pinealoma?",
    "seeds": [
      "Pinealoma"
    ],
    "gold_answer": "Neuroepithelial neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13225",
    "question": "What is associated with Median pseudocleft lip?",
    "seeds": [
      "Median pseudocleft lip"
    ],
    "gold_answer": "Cleft upper lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13226",
    "question": "What is associated with Pulmonary bullae causing pneumothorax?",
    "seeds": [
      "Pulmonary bullae causing pneumothorax"
    ],
    "gold_answer": "Abnormal pleura morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13227",
    "question": "What is associated with Gowers sign?",
    "seeds": [
      "Gowers sign"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13228",
    "question": "What is associated with Abnormal muscle tone?",
    "seeds": [
      "Abnormal muscle tone"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13229",
    "question": "What is associated with Angulated forearm bones?",
    "seeds": [
      "Angulated forearm bones"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13230",
    "question": "What is associated with Frontoocular syndrome?",
    "seeds": [
      "Frontoocular syndrome"
    ],
    "gold_answer": "Abnormal upper lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13231",
    "question": "What is associated with Postpartum exacerbation?",
    "seeds": [
      "Postpartum exacerbation"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13232",
    "question": "What is associated with Non-distal deletion 10q syndrome?",
    "seeds": [
      "Non-distal deletion 10q syndrome"
    ],
    "gold_answer": "Deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13233",
    "question": "What is associated with Gaucher disease, type III?",
    "seeds": [
      "Gaucher disease, type III"
    ],
    "gold_answer": "Supranuclear gaze palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13234",
    "question": "What is associated with Deafness, X-linked 7?",
    "seeds": [
      "Deafness, X-linked 7"
    ],
    "gold_answer": "Microphthalmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13235",
    "question": "What is associated with Elevated circulating acetone concentration?",
    "seeds": [
      "Elevated circulating acetone concentration"
    ],
    "gold_answer": "Hyperketonemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13236",
    "question": "What is associated with Paranasal sinus hypoplasia?",
    "seeds": [
      "Paranasal sinus hypoplasia"
    ],
    "gold_answer": "Absent/hypoplastic paranasal sinuses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13237",
    "question": "What is associated with Primary biliary cholangitis/primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome?",
    "seeds": [
      "Primary biliary cholangitis/primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13238",
    "question": "What is associated with Olfactory lobe agenesis?",
    "seeds": [
      "Olfactory lobe agenesis"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13239",
    "question": "What is associated with Delayed speech and language development?",
    "seeds": [
      "Delayed speech and language development"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13240",
    "question": "What is associated with Anhedonia?",
    "seeds": [
      "Anhedonia"
    ],
    "gold_answer": "Abnormal emotional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13241",
    "question": "What is associated with Patchy sclerosis of the distal phalanx of the 2nd finger?",
    "seeds": [
      "Patchy sclerosis of the distal phalanx of the 2nd finger"
    ],
    "gold_answer": "Sclerosis of 2nd finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13242",
    "question": "What is associated with Neurodevelopmental disorder with poor growth and behavioral abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with poor growth and behavioral abnormalities"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13243",
    "question": "What is associated with Pulmonary venoocclusive disease?",
    "seeds": [
      "Pulmonary venoocclusive disease"
    ],
    "gold_answer": "BMPR2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "candidate_gene_tested_in"
    }
  },
  {
    "query_id": "orph_train_13244",
    "question": "What is associated with Disturbance of facial expression?",
    "seeds": [
      "Disturbance of facial expression"
    ],
    "gold_answer": "Abnormal facial expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13245",
    "question": "What phenotype is associated with Cardiomyopathy, familial hypertrophic, 12?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 12"
    ],
    "gold_answer": "Sudden cardiac death",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13246",
    "question": "What is associated with Limb-girdle muscular dystrophy?",
    "seeds": [
      "Limb-girdle muscular dystrophy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13247",
    "question": "What is associated with Globe retraction and deviation on abduction?",
    "seeds": [
      "Globe retraction and deviation on abduction"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13248",
    "question": "What is associated with Muscular dystrophy, limb-girdle, autosomal recessive 18?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, autosomal recessive 18"
    ],
    "gold_answer": "Limb-girdle muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13249",
    "question": "What is associated with Follicular hyperplasia?",
    "seeds": [
      "Follicular hyperplasia"
    ],
    "gold_answer": "Lymphadenopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13250",
    "question": "What is associated with Alveolar bone loss around teeth?",
    "seeds": [
      "Alveolar bone loss around teeth"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13251",
    "question": "What is associated with Delayed eruption of primary teeth?",
    "seeds": [
      "Delayed eruption of primary teeth"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13252",
    "question": "What is associated with Elevated urinary 3-hydroxyadipic acid level?",
    "seeds": [
      "Elevated urinary 3-hydroxyadipic acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13253",
    "question": "What is associated with Abnormal eyelid physiology?",
    "seeds": [
      "Abnormal eyelid physiology"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13254",
    "question": "What is associated with X-linked intellectual disability, Armfield type?",
    "seeds": [
      "X-linked intellectual disability, Armfield type"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13255",
    "question": "What is associated with Anti-envoplakin antibody positivity?",
    "seeds": [
      "Anti-envoplakin antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13256",
    "question": "What phenotype is associated with Oligomeganephronia?",
    "seeds": [
      "Oligomeganephronia"
    ],
    "gold_answer": "Urethral valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13257",
    "question": "What is associated with Papular xanthoma?",
    "seeds": [
      "Papular xanthoma"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13258",
    "question": "What phenotype is associated with Bleeding disorder, platelet-type, 20?",
    "seeds": [
      "Bleeding disorder, platelet-type, 20"
    ],
    "gold_answer": "Thrombocytopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13259",
    "question": "What is associated with Epidermal thickening?",
    "seeds": [
      "Epidermal thickening"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13260",
    "question": "What phenotype is associated with Spermatogenic failure 89?",
    "seeds": [
      "Spermatogenic failure 89"
    ],
    "gold_answer": "Absent sperm flagella",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13261",
    "question": "What is associated with Lafora bodies?",
    "seeds": [
      "Lafora bodies"
    ],
    "gold_answer": "Cerebral inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13262",
    "question": "What is associated with Myxoid/round cell liposarcoma?",
    "seeds": [
      "Myxoid/round cell liposarcoma"
    ],
    "gold_answer": "DDIT3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_train_13263",
    "question": "What phenotype is associated with Autoimmune polyendocrinopathy type 1?",
    "seeds": [
      "Autoimmune polyendocrinopathy type 1"
    ],
    "gold_answer": "Malabsorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13264",
    "question": "What phenotype is associated with Pontocerebellar hypoplasia, type 10?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 10"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13265",
    "question": "What is associated with Skeletal muscle steatosis?",
    "seeds": [
      "Skeletal muscle steatosis"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13266",
    "question": "What is associated with Adrenocorticotropic hormone deficiency?",
    "seeds": [
      "Adrenocorticotropic hormone deficiency"
    ],
    "gold_answer": "Abnormality of the anterior pituitary",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13267",
    "question": "What is associated with Leukoencephalopathy, progressive, with ovarian failure?",
    "seeds": [
      "Leukoencephalopathy, progressive, with ovarian failure"
    ],
    "gold_answer": "Abnormal superficial reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13268",
    "question": "What is associated with Aplasia/Hypoplasia of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Aplasia/Hypoplasia of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13269",
    "question": "What phenotype is associated with Cutis laxa, neonatal, with marfanoid phenotype?",
    "seeds": [
      "Cutis laxa, neonatal, with marfanoid phenotype"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13270",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 48?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 48"
    ],
    "gold_answer": "Spastic gait",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13271",
    "question": "What is associated with Syndactyly type 5?",
    "seeds": [
      "Syndactyly type 5"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13272",
    "question": "What is associated with Intrarenal abscess?",
    "seeds": [
      "Intrarenal abscess"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13273",
    "question": "What is associated with Multiple cafe-au-lait spots?",
    "seeds": [
      "Multiple cafe-au-lait spots"
    ],
    "gold_answer": "Hypermelanotic macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13274",
    "question": "What is associated with Anti-erythrocyte autoantibody positivity?",
    "seeds": [
      "Anti-erythrocyte autoantibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13275",
    "question": "What phenotype is associated with Bardet-Biedl syndrome 17?",
    "seeds": [
      "Bardet-Biedl syndrome 17"
    ],
    "gold_answer": "Abnormality of abdominal situs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13276",
    "question": "What is associated with Birth length greater than 97th percentile?",
    "seeds": [
      "Birth length greater than 97th percentile"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13277",
    "question": "What is associated with Anti-Zic4 antibody positivity?",
    "seeds": [
      "Anti-Zic4 antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13278",
    "question": "What is associated with Mulchandani-Bhoj-Conlin syndrome?",
    "seeds": [
      "Mulchandani-Bhoj-Conlin syndrome"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13279",
    "question": "What is associated with Dibasicaminoaciduria?",
    "seeds": [
      "Dibasicaminoaciduria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13280",
    "question": "What phenotype is associated with Vitreoretinopathy, neovascular inflammatory?",
    "seeds": [
      "Vitreoretinopathy, neovascular inflammatory"
    ],
    "gold_answer": "Posterior retinal neovascularization",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13281",
    "question": "What phenotype is associated with Deafness, autosomal recessive 76?",
    "seeds": [
      "Deafness, autosomal recessive 76"
    ],
    "gold_answer": "Progressive sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13282",
    "question": "What is associated with Pfeiffer syndrome?",
    "seeds": [
      "Pfeiffer syndrome"
    ],
    "gold_answer": "Abnormal eating behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13283",
    "question": "What is associated with Abnormal circulating progesterone level?",
    "seeds": [
      "Abnormal circulating progesterone level"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13284",
    "question": "What is associated with Grayish enamel?",
    "seeds": [
      "Grayish enamel"
    ],
    "gold_answer": "Abnormality of dental color",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13285",
    "question": "What is associated with Intra-epidermal blistering?",
    "seeds": [
      "Intra-epidermal blistering"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13286",
    "question": "What is associated with Trichilemmoma?",
    "seeds": [
      "Trichilemmoma"
    ],
    "gold_answer": "Neoplasm of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13287",
    "question": "What is associated with Large knee?",
    "seeds": [
      "Large knee"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13288",
    "question": "What is associated with LCAT deficiency?",
    "seeds": [
      "LCAT deficiency"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13289",
    "question": "What is associated with Lymph node necrosis?",
    "seeds": [
      "Lymph node necrosis"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13290",
    "question": "What is associated with Anonychia-microcephaly syndrome?",
    "seeds": [
      "Anonychia-microcephaly syndrome"
    ],
    "gold_answer": "Single transverse palmar crease",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13291",
    "question": "What is associated with Lack of germinal center mitotic figures?",
    "seeds": [
      "Lack of germinal center mitotic figures"
    ],
    "gold_answer": "Abnormal lymph-node follicle architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13292",
    "question": "What is associated with Ameliorated by vitamin D?",
    "seeds": [
      "Ameliorated by vitamin D"
    ],
    "gold_answer": "Ameliorated by exposure to medication",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13293",
    "question": "What phenotype is associated with Joubert syndrome 23?",
    "seeds": [
      "Joubert syndrome 23"
    ],
    "gold_answer": "Tachypnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13294",
    "question": "What is associated with Reduced circulating transferrin concentration?",
    "seeds": [
      "Reduced circulating transferrin concentration"
    ],
    "gold_answer": "Abnormal circulating transferrin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13295",
    "question": "What is associated with Abnormal coronary artery course?",
    "seeds": [
      "Abnormal coronary artery course"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13296",
    "question": "What is associated with Abnormal B cell physiology?",
    "seeds": [
      "Abnormal B cell physiology"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13297",
    "question": "What is associated with Reduced fibroblast surface marker level?",
    "seeds": [
      "Reduced fibroblast surface marker level"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13298",
    "question": "What phenotype is associated with Marden-Walker syndrome?",
    "seeds": [
      "Marden-Walker syndrome"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13299",
    "question": "What is associated with Increased intraabdominal fat?",
    "seeds": [
      "Increased intraabdominal fat"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13300",
    "question": "What is associated with Permanent atrial fibrillation?",
    "seeds": [
      "Permanent atrial fibrillation"
    ],
    "gold_answer": "Atrial arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13301",
    "question": "What is associated with Persistent open anterior fontanelle?",
    "seeds": [
      "Persistent open anterior fontanelle"
    ],
    "gold_answer": "Abnormal fontanelle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13302",
    "question": "What is associated with Renal lymphocytic tubulitis?",
    "seeds": [
      "Renal lymphocytic tubulitis"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13303",
    "question": "What is associated with Abnormal enzyme concentration or activity?",
    "seeds": [
      "Abnormal enzyme concentration or activity"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13304",
    "question": "What is associated with Vaginal mass?",
    "seeds": [
      "Vaginal mass"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13305",
    "question": "What is associated with Head titubation?",
    "seeds": [
      "Head titubation"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13306",
    "question": "What is associated with Ivory epiphysis of the proximal phalanx of the thumb?",
    "seeds": [
      "Ivory epiphysis of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13307",
    "question": "What is associated with Hepatojugular reflux?",
    "seeds": [
      "Hepatojugular reflux"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13308",
    "question": "What is associated with Inability to walk?",
    "seeds": [
      "Inability to walk"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13309",
    "question": "What is associated with DEAFNESS, Y-LINKED 1?",
    "seeds": [
      "DEAFNESS, Y-LINKED 1"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13310",
    "question": "What is associated with Large humeral epiphyses?",
    "seeds": [
      "Large humeral epiphyses"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13311",
    "question": "What is associated with Positive hydrogen breath test?",
    "seeds": [
      "Positive hydrogen breath test"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13312",
    "question": "What is associated with Tubulointerstitial nephritis?",
    "seeds": [
      "Tubulointerstitial nephritis"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13313",
    "question": "What is associated with Patchy sclerosis of 4th toe phalanx?",
    "seeds": [
      "Patchy sclerosis of 4th toe phalanx"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13314",
    "question": "What phenotype is associated with Secondary non-traumatic avascular necrosis?",
    "seeds": [
      "Secondary non-traumatic avascular necrosis"
    ],
    "gold_answer": "Anti-titin antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13315",
    "question": "What phenotype is associated with Distal 7q11.23 microduplication syndrome?",
    "seeds": [
      "Distal 7q11.23 microduplication syndrome"
    ],
    "gold_answer": "Autistic behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13316",
    "question": "What is associated with Chromosome 19q13.11 deletion syndrome, proximal?",
    "seeds": [
      "Chromosome 19q13.11 deletion syndrome, proximal"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13317",
    "question": "What phenotype is associated with Trichothiodystrophy?",
    "seeds": [
      "Trichothiodystrophy"
    ],
    "gold_answer": "Microcornea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13318",
    "question": "What is associated with Focal absence of the external ear?",
    "seeds": [
      "Focal absence of the external ear"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13319",
    "question": "What is associated with Retinal pigment epithelial loss on macular OCT?",
    "seeds": [
      "Retinal pigment epithelial loss on macular OCT"
    ],
    "gold_answer": "Abnormal posterior segment imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13320",
    "question": "What phenotype is associated with Maternal uniparental disomy of chromosome X syndrome?",
    "seeds": [
      "Maternal uniparental disomy of chromosome X syndrome"
    ],
    "gold_answer": "Short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13321",
    "question": "What is associated with Fourth ray metatarsophalangeal synostosis?",
    "seeds": [
      "Fourth ray metatarsophalangeal synostosis"
    ],
    "gold_answer": "Metatarsal synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13322",
    "question": "What is associated with Lipoma of the conjunctiva?",
    "seeds": [
      "Lipoma of the conjunctiva"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13323",
    "question": "What is associated with Diaphragmatic paralysis?",
    "seeds": [
      "Diaphragmatic paralysis"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13324",
    "question": "What is associated with Reduced hepatic urocanase activity?",
    "seeds": [
      "Reduced hepatic urocanase activity"
    ],
    "gold_answer": "Abnormal liver enzyme activity or concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13325",
    "question": "What is associated with Heparin-induced thrombocytopenia?",
    "seeds": [
      "Heparin-induced thrombocytopenia"
    ],
    "gold_answer": "Abnormal platelet count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13326",
    "question": "What is associated with Proximal tubulopathy?",
    "seeds": [
      "Proximal tubulopathy"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13327",
    "question": "What is associated with Decreased circulating heparan sulfate level?",
    "seeds": [
      "Decreased circulating heparan sulfate level"
    ],
    "gold_answer": "Abnormal circulating carbohydrate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13328",
    "question": "What is associated with Abnormality of mouth shape?",
    "seeds": [
      "Abnormality of mouth shape"
    ],
    "gold_answer": "Abnormality of the mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13329",
    "question": "What is associated with Hurthle cell thyroid adenoma?",
    "seeds": [
      "Hurthle cell thyroid adenoma"
    ],
    "gold_answer": "Neoplasm of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13330",
    "question": "What is associated with Occupational history of putting fingers in other people's mouths?",
    "seeds": [
      "Occupational history of putting fingers in other people's mouths"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13331",
    "question": "What is associated with Tako-Tsubo cardiomyopathy?",
    "seeds": [
      "Tako-Tsubo cardiomyopathy"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13332",
    "question": "What is associated with Hyperprolinemia type 2?",
    "seeds": [
      "Hyperprolinemia type 2"
    ],
    "gold_answer": "Abnormal circulating pyruvate family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13333",
    "question": "What is associated with Transketolase deficiency?",
    "seeds": [
      "Transketolase deficiency"
    ],
    "gold_answer": "Abnormal conjunctiva morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13334",
    "question": "What is associated with Ciliary dyskinesia, primary, 16?",
    "seeds": [
      "Ciliary dyskinesia, primary, 16"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13335",
    "question": "What is associated with Combined deficiency of factor V and factor VIII type 2?",
    "seeds": [
      "Combined deficiency of factor V and factor VIII type 2"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13336",
    "question": "What is associated with Stippled calcification of the humeral epiphyses?",
    "seeds": [
      "Stippled calcification of the humeral epiphyses"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13337",
    "question": "What is associated with Bullet-shaped proximal toe phalanx?",
    "seeds": [
      "Bullet-shaped proximal toe phalanx"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13338",
    "question": "What is associated with Chronic CSF lymphocytosis?",
    "seeds": [
      "Chronic CSF lymphocytosis"
    ],
    "gold_answer": "CSF lymphocytic pleiocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13339",
    "question": "What is associated with Dysplastic testis?",
    "seeds": [
      "Dysplastic testis"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13340",
    "question": "What is associated with Disseminated nontuberculous mycobacterial infection?",
    "seeds": [
      "Disseminated nontuberculous mycobacterial infection"
    ],
    "gold_answer": "Opportunistic bacterial infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13341",
    "question": "What is associated with Hypoxemia in cord blood?",
    "seeds": [
      "Hypoxemia in cord blood"
    ],
    "gold_answer": "Abnormal blood gas level in cord blood",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13342",
    "question": "What is associated with Elbow extension contracture?",
    "seeds": [
      "Elbow extension contracture"
    ],
    "gold_answer": "Limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13343",
    "question": "What is associated with Abnormal interlobular vein intima/media morphology?",
    "seeds": [
      "Abnormal interlobular vein intima/media morphology"
    ],
    "gold_answer": "Abnormal renal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13344",
    "question": "What is associated with Duplication of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Duplication of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal 2nd toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13345",
    "question": "What phenotype is associated with Glycosylphosphatidylinositol biosynthesis defect 16?",
    "seeds": [
      "Glycosylphosphatidylinositol biosynthesis defect 16"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13346",
    "question": "What is associated with Hyperpigmentation of the skin?",
    "seeds": [
      "Hyperpigmentation of the skin"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13347",
    "question": "What phenotype is associated with Spinocerebellar ataxia 15?",
    "seeds": [
      "Spinocerebellar ataxia 15"
    ],
    "gold_answer": "Limb ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13348",
    "question": "What is associated with Autosomal recessive ataxia due to PEX16 deficiency?",
    "seeds": [
      "Autosomal recessive ataxia due to PEX16 deficiency"
    ],
    "gold_answer": "PEX16",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13349",
    "question": "What is associated with Urethrovaginal fistula?",
    "seeds": [
      "Urethrovaginal fistula"
    ],
    "gold_answer": "Abnormality of the urethra",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13350",
    "question": "What is associated with Aromatase excess syndrome?",
    "seeds": [
      "Aromatase excess syndrome"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13351",
    "question": "What is associated with Mediosternal depigmentation line?",
    "seeds": [
      "Mediosternal depigmentation line"
    ],
    "gold_answer": "Hypopigmented streaks",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13352",
    "question": "What is associated with Abnormality of depressor labii inferioris?",
    "seeds": [
      "Abnormality of depressor labii inferioris"
    ],
    "gold_answer": "Abnormality of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13353",
    "question": "What is associated with Abnormality of the eye?",
    "seeds": [
      "Abnormality of the eye"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13354",
    "question": "What is associated with Bracket epiphysis of the middle phalanx of the 5th toe?",
    "seeds": [
      "Bracket epiphysis of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Bracket epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13355",
    "question": "What is associated with Pugilistic facies?",
    "seeds": [
      "Pugilistic facies"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13356",
    "question": "What is associated with Chronic noninfectious lymphadenopathy?",
    "seeds": [
      "Chronic noninfectious lymphadenopathy"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13357",
    "question": "What is associated with Elevated urine guanidinoacetic acid level?",
    "seeds": [
      "Elevated urine guanidinoacetic acid level"
    ],
    "gold_answer": "Abnormal urine guanidinoacetic acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13358",
    "question": "What phenotype is associated with Metatropic dysplasia?",
    "seeds": [
      "Metatropic dysplasia"
    ],
    "gold_answer": "Flared iliac wing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13359",
    "question": "What is associated with Renal arteriole neutrophil endoarterial hypercellularity?",
    "seeds": [
      "Renal arteriole neutrophil endoarterial hypercellularity"
    ],
    "gold_answer": "Renal arteriole endoarterial hypercellularity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13360",
    "question": "What is associated with Ureteral obstruction?",
    "seeds": [
      "Ureteral obstruction"
    ],
    "gold_answer": "Abnormal ureter physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13361",
    "question": "What is associated with Abnormal circulating beta-mannosidase activity?",
    "seeds": [
      "Abnormal circulating beta-mannosidase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13362",
    "question": "What is associated with Pulsatile mass in extremity?",
    "seeds": [
      "Pulsatile mass in extremity"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13363",
    "question": "What is associated with Duplication of phalanx of 5th finger?",
    "seeds": [
      "Duplication of phalanx of 5th finger"
    ],
    "gold_answer": "Duplication of bones involving the upper extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13364",
    "question": "What is associated with Lichtenstein-Knorr syndrome?",
    "seeds": [
      "Lichtenstein-Knorr syndrome"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13365",
    "question": "What is associated with Sanfilippo syndrome type B?",
    "seeds": [
      "Sanfilippo syndrome type B"
    ],
    "gold_answer": "NAGLU",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_13366",
    "question": "What is associated with Agenesis of pulmonary vessels?",
    "seeds": [
      "Agenesis of pulmonary vessels"
    ],
    "gold_answer": "Abnormality of the pulmonary vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13367",
    "question": "What is associated with Superior crossed-fused renal ectopia?",
    "seeds": [
      "Superior crossed-fused renal ectopia"
    ],
    "gold_answer": "Ectopic kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13368",
    "question": "What phenotype is associated with ReNU syndrome?",
    "seeds": [
      "ReNU syndrome"
    ],
    "gold_answer": "Wide mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13369",
    "question": "What phenotype is associated with Parasomnia, Sleepwalking type?",
    "seeds": [
      "Parasomnia, Sleepwalking type"
    ],
    "gold_answer": "Sleep terror",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13370",
    "question": "What is associated with Fetal phenytoin exposure?",
    "seeds": [
      "Fetal phenytoin exposure"
    ],
    "gold_answer": "Fetal exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13371",
    "question": "What is associated with Abdominal aortic calcification?",
    "seeds": [
      "Abdominal aortic calcification"
    ],
    "gold_answer": "Vascular calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13372",
    "question": "What is associated with Reduced prothrombin antigen?",
    "seeds": [
      "Reduced prothrombin antigen"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13373",
    "question": "What is associated with Abnormal speech rhythm?",
    "seeds": [
      "Abnormal speech rhythm"
    ],
    "gold_answer": "Abnormal prosody",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13374",
    "question": "What is associated with Chromosome 6pter-p24 deletion syndrome?",
    "seeds": [
      "Chromosome 6pter-p24 deletion syndrome"
    ],
    "gold_answer": "Constipation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13375",
    "question": "What is associated with Prune belly?",
    "seeds": [
      "Prune belly"
    ],
    "gold_answer": "Abnormal abdominal wall morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13376",
    "question": "What is associated with Intracranial dermoid cyst?",
    "seeds": [
      "Intracranial dermoid cyst"
    ],
    "gold_answer": "Intracranial cystic lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13377",
    "question": "What is associated with Spina bifida occulta?",
    "seeds": [
      "Spina bifida occulta"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13378",
    "question": "What is associated with Anterior chamber cells grade 3+?",
    "seeds": [
      "Anterior chamber cells grade 3+"
    ],
    "gold_answer": "Abnormal anterior chamber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13379",
    "question": "What is associated with Timothy syndrome?",
    "seeds": [
      "Timothy syndrome"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13380",
    "question": "What phenotype is associated with Striatonigral degeneration, infantile?",
    "seeds": [
      "Striatonigral degeneration, infantile"
    ],
    "gold_answer": "Choreoathetosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13381",
    "question": "What is associated with Nonketotic hyperglycinemia?",
    "seeds": [
      "Nonketotic hyperglycinemia"
    ],
    "gold_answer": "Abnormal circulating glycine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13382",
    "question": "What is associated with Metacarpal 4-5 fusion?",
    "seeds": [
      "Metacarpal 4-5 fusion"
    ],
    "gold_answer": "Cutaneous syndactyly of toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13383",
    "question": "What is associated with Posterior staphyloma?",
    "seeds": [
      "Posterior staphyloma"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13384",
    "question": "What phenotype is associated with Melanoma-Astrocytoma syndrome?",
    "seeds": [
      "Melanoma-Astrocytoma syndrome"
    ],
    "gold_answer": "Astrocytoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13385",
    "question": "What is associated with Ivory epiphysis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Ivory epiphysis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Ivory epiphyses of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13386",
    "question": "What is associated with Limited wrist movement?",
    "seeds": [
      "Limited wrist movement"
    ],
    "gold_answer": "Abnormality of upper limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13387",
    "question": "What is associated with Elevated circulating D-dimer concentration?",
    "seeds": [
      "Elevated circulating D-dimer concentration"
    ],
    "gold_answer": "Abnormality of fibrinolysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13388",
    "question": "What is associated with Preaxial deficiency, postaxial polydactyly, and hypospadias?",
    "seeds": [
      "Preaxial deficiency, postaxial polydactyly, and hypospadias"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13389",
    "question": "What is associated with Digital arthropathy-brachydactyly, familial?",
    "seeds": [
      "Digital arthropathy-brachydactyly, familial"
    ],
    "gold_answer": "Abnormal middle phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13390",
    "question": "What is associated with Double-layered patella?",
    "seeds": [
      "Double-layered patella"
    ],
    "gold_answer": "Abnormal knee morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13391",
    "question": "What is associated with Elevated circulating CCL3 concentration?",
    "seeds": [
      "Elevated circulating CCL3 concentration"
    ],
    "gold_answer": "Abnormal circulating CC chemokine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13392",
    "question": "What is associated with Hyperthermia, cutaneous, with headaches and nausea?",
    "seeds": [
      "Hyperthermia, cutaneous, with headaches and nausea"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13393",
    "question": "What is associated with Abnormal hair morphology?",
    "seeds": [
      "Abnormal hair morphology"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13394",
    "question": "What is associated with Abnormal shape of the occiput?",
    "seeds": [
      "Abnormal shape of the occiput"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13395",
    "question": "What is associated with Cone-shaped epiphysis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Cone-shaped epiphysis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13396",
    "question": "What is associated with Broad diaphyses of the upper limbs?",
    "seeds": [
      "Broad diaphyses of the upper limbs"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13397",
    "question": "What phenotype is associated with WAC-related facial dysmorphism-developmental delay-behavioral abnormalities syndrome?",
    "seeds": [
      "WAC-related facial dysmorphism-developmental delay-behavioral abnormalities syndrome"
    ],
    "gold_answer": "Vertigo",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13398",
    "question": "What is associated with Neurofibrosarcoma?",
    "seeds": [
      "Neurofibrosarcoma"
    ],
    "gold_answer": "Soft tissue sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13399",
    "question": "What is associated with Parasite allergy?",
    "seeds": [
      "Parasite allergy"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13400",
    "question": "What is associated with Elevated urinary 3-hydroxyadipic acid level?",
    "seeds": [
      "Elevated urinary 3-hydroxyadipic acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13401",
    "question": "What is associated with Ankle joint effusion?",
    "seeds": [
      "Ankle joint effusion"
    ],
    "gold_answer": "Abnormality of the ankle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13402",
    "question": "What is associated with Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive?",
    "seeds": [
      "Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive"
    ],
    "gold_answer": "Peripheral axonal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13403",
    "question": "What is associated with Infantile dystonia-parkinsonism?",
    "seeds": [
      "Infantile dystonia-parkinsonism"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13404",
    "question": "What is associated with Double elevator palsy?",
    "seeds": [
      "Double elevator palsy"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13405",
    "question": "What is associated with Increased level of D-threitol in plasma?",
    "seeds": [
      "Increased level of D-threitol in plasma"
    ],
    "gold_answer": "Abnormal circulating carbohydrate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13406",
    "question": "What is associated with Transient bullous dermolysis of the newborn?",
    "seeds": [
      "Transient bullous dermolysis of the newborn"
    ],
    "gold_answer": "Scarring",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13407",
    "question": "What is associated with Mirage syndrome?",
    "seeds": [
      "Mirage syndrome"
    ],
    "gold_answer": "Deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13408",
    "question": "What is associated with Decreased Th17 T cell proportion?",
    "seeds": [
      "Decreased Th17 T cell proportion"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13409",
    "question": "What is associated with Chronic active hepatitis?",
    "seeds": [
      "Chronic active hepatitis"
    ],
    "gold_answer": "Hepatitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13410",
    "question": "What phenotype is associated with Oculogastrointestinal neurodevelopmental syndrome?",
    "seeds": [
      "Oculogastrointestinal neurodevelopmental syndrome"
    ],
    "gold_answer": "Hirsutism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13411",
    "question": "What phenotype is associated with Periventricular nodular heterotopia 6?",
    "seeds": [
      "Periventricular nodular heterotopia 6"
    ],
    "gold_answer": "Esophagitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13412",
    "question": "What is associated with Tangier disease?",
    "seeds": [
      "Tangier disease"
    ],
    "gold_answer": "Hyperlipidemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13413",
    "question": "What is associated with Increased radioactive iodine uptake?",
    "seeds": [
      "Increased radioactive iodine uptake"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13414",
    "question": "What is associated with Glycogen accumulation in muscle fiber lysosomes?",
    "seeds": [
      "Glycogen accumulation in muscle fiber lysosomes"
    ],
    "gold_answer": "Abnormal muscle glycogen content",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13415",
    "question": "What phenotype is associated with Cutaneous mastocytosis-deafness-microtia syndrome?",
    "seeds": [
      "Cutaneous mastocytosis-deafness-microtia syndrome"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13416",
    "question": "What is associated with Aplasia/hypoplasia of the femur?",
    "seeds": [
      "Aplasia/hypoplasia of the femur"
    ],
    "gold_answer": "Aplasia/hypoplasia of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13417",
    "question": "What is associated with Abnormal cartilage morphology?",
    "seeds": [
      "Abnormal cartilage morphology"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13418",
    "question": "What is associated with Lateral neck mass?",
    "seeds": [
      "Lateral neck mass"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13419",
    "question": "What is associated with Acrosomal hypoplasia?",
    "seeds": [
      "Acrosomal hypoplasia"
    ],
    "gold_answer": "Abnormal sperm head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13420",
    "question": "What phenotype is associated with Congenital lobar emphysema?",
    "seeds": [
      "Congenital lobar emphysema"
    ],
    "gold_answer": "Wheezing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13421",
    "question": "What is associated with Elevated CSF D-glyceric acid concentration?",
    "seeds": [
      "Elevated CSF D-glyceric acid concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13422",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 6, with or without seizures?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 6, with or without seizures"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13423",
    "question": "What is associated with Hypoplasia of facial musculature?",
    "seeds": [
      "Hypoplasia of facial musculature"
    ],
    "gold_answer": "Abnormality of facial soft tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13424",
    "question": "What is associated with Neoplasm of the gallbladder?",
    "seeds": [
      "Neoplasm of the gallbladder"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13425",
    "question": "What phenotype is associated with Tumor predisposition syndrome 2?",
    "seeds": [
      "Tumor predisposition syndrome 2"
    ],
    "gold_answer": "Memory impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13426",
    "question": "What phenotype is associated with Mitochondrial complex I deficiency, nuclear type 9?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 9"
    ],
    "gold_answer": "Decreased activity of mitochondrial complex I",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13427",
    "question": "What is associated with Elevated urine 3-hydroxyglutaric level?",
    "seeds": [
      "Elevated urine 3-hydroxyglutaric level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13428",
    "question": "What phenotype is associated with Witkop syndrome?",
    "seeds": [
      "Witkop syndrome"
    ],
    "gold_answer": "Abnormal sweat gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13429",
    "question": "What is associated with Increased fetal movement?",
    "seeds": [
      "Increased fetal movement"
    ],
    "gold_answer": "Prenatal movement abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13430",
    "question": "What is associated with Abnormal antitragus morphology?",
    "seeds": [
      "Abnormal antitragus morphology"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13431",
    "question": "What is associated with Cortical dysplasia, complex, with other brain malformations 3?",
    "seeds": [
      "Cortical dysplasia, complex, with other brain malformations 3"
    ],
    "gold_answer": "Abnormal cerebral cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13432",
    "question": "What is associated with Vertebral fusion, posterior lumbosacral, with blepharoptosis?",
    "seeds": [
      "Vertebral fusion, posterior lumbosacral, with blepharoptosis"
    ],
    "gold_answer": "ZFHX4",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "candidate_gene_tested_in"
    }
  },
  {
    "query_id": "orph_train_13433",
    "question": "What is associated with Focal impaired awareness orofacial automatism seizure?",
    "seeds": [
      "Focal impaired awareness orofacial automatism seizure"
    ],
    "gold_answer": "Focal impaired awareness seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13434",
    "question": "What is associated with Ear pain exacerbated by manipulating tragus or pinna?",
    "seeds": [
      "Ear pain exacerbated by manipulating tragus or pinna"
    ],
    "gold_answer": "Aggravated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13435",
    "question": "What is associated with Progressive microcephaly?",
    "seeds": [
      "Progressive microcephaly"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13436",
    "question": "What is associated with Hyperlipidemia, familial combined, 3?",
    "seeds": [
      "Hyperlipidemia, familial combined, 3"
    ],
    "gold_answer": "Increased circulating apolipoprotein circulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13437",
    "question": "What is associated with Cleft lip/palate-intestinal malrotation-cardiopathy syndrome?",
    "seeds": [
      "Cleft lip/palate-intestinal malrotation-cardiopathy syndrome"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13438",
    "question": "What is associated with Elevated circulating trypsinogen concentration?",
    "seeds": [
      "Elevated circulating trypsinogen concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13439",
    "question": "What is associated with Megaloblepharon?",
    "seeds": [
      "Megaloblepharon"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13440",
    "question": "What is associated with Complex renal cyst?",
    "seeds": [
      "Complex renal cyst"
    ],
    "gold_answer": "Renal cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13441",
    "question": "What is associated with Triggered by high-fat diet?",
    "seeds": [
      "Triggered by high-fat diet"
    ],
    "gold_answer": "Triggered by",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13442",
    "question": "What is associated with Aphasia?",
    "seeds": [
      "Aphasia"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13443",
    "question": "What is associated with Bardet-Biedl syndrome 22?",
    "seeds": [
      "Bardet-Biedl syndrome 22"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13444",
    "question": "What is associated with Focal-onset seizure evolving into bilateral convulsive status epilepticus?",
    "seeds": [
      "Focal-onset seizure evolving into bilateral convulsive status epilepticus"
    ],
    "gold_answer": "Status epilepticus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13445",
    "question": "What is associated with Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome?",
    "seeds": [
      "Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13446",
    "question": "What is associated with Xeroderma pigmentosum, complementation group D?",
    "seeds": [
      "Xeroderma pigmentosum, complementation group D"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the central nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13447",
    "question": "What is associated with Abnormal circulating selenium concentration?",
    "seeds": [
      "Abnormal circulating selenium concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13448",
    "question": "What is associated with Elevated circulating N,N-dimethylglycine concentration?",
    "seeds": [
      "Elevated circulating N,N-dimethylglycine concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13449",
    "question": "What is associated with Hopelessness?",
    "seeds": [
      "Hopelessness"
    ],
    "gold_answer": "Abnormal preoccupation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13450",
    "question": "What is associated with Autosomal dominant intermediate Charcot-Marie-Tooth disease type E?",
    "seeds": [
      "Autosomal dominant intermediate Charcot-Marie-Tooth disease type E"
    ],
    "gold_answer": "INF2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13451",
    "question": "What is associated with Acrorenal-Mandibular syndrome?",
    "seeds": [
      "Acrorenal-Mandibular syndrome"
    ],
    "gold_answer": "Abnormality of the diaphragm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13452",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, axonal, type 2D?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2D"
    ],
    "gold_answer": "Thenar muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13453",
    "question": "What is associated with Mediastinal mass?",
    "seeds": [
      "Mediastinal mass"
    ],
    "gold_answer": "Abnormal pulmonary thoracic imaging finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13454",
    "question": "What is associated with Severe primary trimethylaminuria?",
    "seeds": [
      "Severe primary trimethylaminuria"
    ],
    "gold_answer": "Abnormal volitional state",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13455",
    "question": "What is associated with Squamous metaplasia?",
    "seeds": [
      "Squamous metaplasia"
    ],
    "gold_answer": "Histopathological abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13456",
    "question": "What is associated with Ivory epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Ivory epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the epiphysis of the middle phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13457",
    "question": "What is associated with Fractured facial bone?",
    "seeds": [
      "Fractured facial bone"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13458",
    "question": "What is associated with Abnormal social behavior?",
    "seeds": [
      "Abnormal social behavior"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13459",
    "question": "What is associated with Transient nephrotic syndrome?",
    "seeds": [
      "Transient nephrotic syndrome"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13460",
    "question": "What is associated with Neurodevelopmental disorder with absent language and variable seizures?",
    "seeds": [
      "Neurodevelopmental disorder with absent language and variable seizures"
    ],
    "gold_answer": "Abnormal cerebral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13461",
    "question": "What is associated with Cystoid macular edema?",
    "seeds": [
      "Cystoid macular edema"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13462",
    "question": "What is associated with Isolated focal non-epidermolytic palmoplantar keratoderma?",
    "seeds": [
      "Isolated focal non-epidermolytic palmoplantar keratoderma"
    ],
    "gold_answer": "TRPV3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_train_13463",
    "question": "What is associated with Cartilaginous tracheobronchomalacia?",
    "seeds": [
      "Cartilaginous tracheobronchomalacia"
    ],
    "gold_answer": "Tracheobronchomalacia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13464",
    "question": "What is associated with Food allergy?",
    "seeds": [
      "Food allergy"
    ],
    "gold_answer": "Allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13465",
    "question": "What is associated with External carotid artery calcification?",
    "seeds": [
      "External carotid artery calcification"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13466",
    "question": "What is associated with Auditory hypersensitivity?",
    "seeds": [
      "Auditory hypersensitivity"
    ],
    "gold_answer": "Sensory hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13467",
    "question": "What phenotype is associated with 46,xy sex reversal 6?",
    "seeds": [
      "46,xy sex reversal 6"
    ],
    "gold_answer": "Hirsutism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13468",
    "question": "What phenotype is associated with Frank-Ter Haar syndrome?",
    "seeds": [
      "Frank-Ter Haar syndrome"
    ],
    "gold_answer": "Broad forehead",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13469",
    "question": "What is associated with Abnormal 3rd finger morphology?",
    "seeds": [
      "Abnormal 3rd finger morphology"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13470",
    "question": "What is associated with Ivory epiphysis of the 1st metatarsal?",
    "seeds": [
      "Ivory epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Ivory epiphyses of the hallux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13471",
    "question": "What is associated with Spastic paraplegia-precocious puberty syndrome?",
    "seeds": [
      "Spastic paraplegia-precocious puberty syndrome"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13472",
    "question": "What is associated with Perinephric abscess?",
    "seeds": [
      "Perinephric abscess"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13473",
    "question": "What is associated with Cooper-Jabs syndrome?",
    "seeds": [
      "Cooper-Jabs syndrome"
    ],
    "gold_answer": "Flexion contracture of digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13474",
    "question": "What is associated with Abnormal lens morphology?",
    "seeds": [
      "Abnormal lens morphology"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13475",
    "question": "What is associated with Inclusion body fibromatosis?",
    "seeds": [
      "Inclusion body fibromatosis"
    ],
    "gold_answer": "Fibrous tissue neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13476",
    "question": "What phenotype is associated with Wilms tumor 7?",
    "seeds": [
      "Wilms tumor 7"
    ],
    "gold_answer": "Nephroblastoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13477",
    "question": "What is associated with Humeroulnar synostosis?",
    "seeds": [
      "Humeroulnar synostosis"
    ],
    "gold_answer": "Abnormality of the elbow",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13478",
    "question": "What is associated with Fetal and neonatal alloimmune thrombocytopenia?",
    "seeds": [
      "Fetal and neonatal alloimmune thrombocytopenia"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13479",
    "question": "What is associated with Spastic paraplegia 52, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 52, autosomal recessive"
    ],
    "gold_answer": "Infection-related seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13480",
    "question": "What phenotype is associated with Familial hyperaldosteronism type III?",
    "seeds": [
      "Familial hyperaldosteronism type III"
    ],
    "gold_answer": "Intracranial hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13481",
    "question": "What phenotype is associated with Restrictive dermopathy 1?",
    "seeds": [
      "Restrictive dermopathy 1"
    ],
    "gold_answer": "Hypertelorism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13482",
    "question": "What is associated with Klippel-Feil syndrome, autosomal recessive?",
    "seeds": [
      "Klippel-Feil syndrome, autosomal recessive"
    ],
    "gold_answer": "Abnormal cardiac septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13483",
    "question": "What is associated with Generalized hypotrichosis?",
    "seeds": [
      "Generalized hypotrichosis"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13484",
    "question": "What is associated with Aplasia/Hypoplasia of the midbrain?",
    "seeds": [
      "Aplasia/Hypoplasia of the midbrain"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13485",
    "question": "What is associated with Adenomatous colonic polyposis?",
    "seeds": [
      "Adenomatous colonic polyposis"
    ],
    "gold_answer": "Neoplasm of the colon",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13486",
    "question": "What is associated with Increased immature B cell proportion?",
    "seeds": [
      "Increased immature B cell proportion"
    ],
    "gold_answer": "Abnormal B cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13487",
    "question": "What is associated with History of recent participation in athletics?",
    "seeds": [
      "History of recent participation in athletics"
    ],
    "gold_answer": "Recent past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13488",
    "question": "What is associated with Rajab interstitial lung disease with brain calcifications?",
    "seeds": [
      "Rajab interstitial lung disease with brain calcifications"
    ],
    "gold_answer": "Abnormal systemic blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13489",
    "question": "What is associated with Sheldon-Hall syndrome?",
    "seeds": [
      "Sheldon-Hall syndrome"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13490",
    "question": "What is associated with Blepharochalasis, superior?",
    "seeds": [
      "Blepharochalasis, superior"
    ],
    "gold_answer": "Palpebral edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13491",
    "question": "What is associated with Decreased alpha-galactosidase A activity?",
    "seeds": [
      "Decreased alpha-galactosidase A activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13492",
    "question": "What is associated with Loss of ability to walk in first decade?",
    "seeds": [
      "Loss of ability to walk in first decade"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13493",
    "question": "What is associated with Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads?",
    "seeds": [
      "Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads"
    ],
    "gold_answer": "Abnormality of nail color",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13494",
    "question": "What is associated with Elevated brain N-acetyl aspartate level by MRS?",
    "seeds": [
      "Elevated brain N-acetyl aspartate level by MRS"
    ],
    "gold_answer": "Abnormal metabolic brain imaging by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13495",
    "question": "What is associated with Osteomyelitis leading to amputation due to slow healing fractures?",
    "seeds": [
      "Osteomyelitis leading to amputation due to slow healing fractures"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13496",
    "question": "What is associated with Areas of hypopigmentation and hyperpigmentation that follow Blaschko lines?",
    "seeds": [
      "Areas of hypopigmentation and hyperpigmentation that follow Blaschko lines"
    ],
    "gold_answer": "Hyperpigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13497",
    "question": "What is associated with Reduced proximal interphalangeal joint space?",
    "seeds": [
      "Reduced proximal interphalangeal joint space"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13498",
    "question": "What is associated with Agenesis of permanent mandibular central incisor?",
    "seeds": [
      "Agenesis of permanent mandibular central incisor"
    ],
    "gold_answer": "Agenesis of mandibular incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13499",
    "question": "What is associated with Abnormal location of the eyebrow?",
    "seeds": [
      "Abnormal location of the eyebrow"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13500",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 70?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 70"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13501",
    "question": "What is associated with Rasmussen subacute encephalitis?",
    "seeds": [
      "Rasmussen subacute encephalitis"
    ],
    "gold_answer": "Abnormal cerebral cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13502",
    "question": "What is associated with Unusual gastrointestinal infection?",
    "seeds": [
      "Unusual gastrointestinal infection"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13503",
    "question": "What is associated with Glycogen storage disease due to phosphoglycerate kinase 1 deficiency?",
    "seeds": [
      "Glycogen storage disease due to phosphoglycerate kinase 1 deficiency"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13504",
    "question": "What is associated with Placenta increta?",
    "seeds": [
      "Placenta increta"
    ],
    "gold_answer": "Abnormal placenta morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13505",
    "question": "What is associated with Bone marrow hypocellularity?",
    "seeds": [
      "Bone marrow hypocellularity"
    ],
    "gold_answer": "Abnormal bone marrow cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13506",
    "question": "What is associated with Conjunctival cicatrization?",
    "seeds": [
      "Conjunctival cicatrization"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13507",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 60?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 60"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13508",
    "question": "What is associated with Central adrenal insufficiency?",
    "seeds": [
      "Central adrenal insufficiency"
    ],
    "gold_answer": "Abnormality of the adrenal glands",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13509",
    "question": "What is associated with Open angle glaucoma?",
    "seeds": [
      "Open angle glaucoma"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13510",
    "question": "What is associated with Sclerosis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Sclerosis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13511",
    "question": "What is associated with Abnormality of the urinary system?",
    "seeds": [
      "Abnormality of the urinary system"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13512",
    "question": "What phenotype is associated with Epidermolysis bullosa simplex 2B, generalized intermediate?",
    "seeds": [
      "Epidermolysis bullosa simplex 2B, generalized intermediate"
    ],
    "gold_answer": "Palmoplantar blistering",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13513",
    "question": "What is associated with Null syndrome?",
    "seeds": [
      "Null syndrome"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13514",
    "question": "What is associated with Donohue syndrome?",
    "seeds": [
      "Donohue syndrome"
    ],
    "gold_answer": "Ventricular hypertrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13515",
    "question": "What is associated with Cranial asymmetry?",
    "seeds": [
      "Cranial asymmetry"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13516",
    "question": "What is associated with Paragangliomas 2?",
    "seeds": [
      "Paragangliomas 2"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13517",
    "question": "What phenotype is associated with X-linked intellectual disability, Cilliers type?",
    "seeds": [
      "X-linked intellectual disability, Cilliers type"
    ],
    "gold_answer": "Failure to thrive",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13518",
    "question": "What is associated with Disturbed perception with a stimulus?",
    "seeds": [
      "Disturbed perception with a stimulus"
    ],
    "gold_answer": "Abnormal interpretation of external stimuli",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13519",
    "question": "What is associated with EEG with focal slow activity?",
    "seeds": [
      "EEG with focal slow activity"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13520",
    "question": "What is associated with Bullet-shaped distal phalanx of the 4th toe?",
    "seeds": [
      "Bullet-shaped distal phalanx of the 4th toe"
    ],
    "gold_answer": "Bullet-shaped 4th toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13521",
    "question": "What is associated with Type A2 brachydactyly?",
    "seeds": [
      "Type A2 brachydactyly"
    ],
    "gold_answer": "Brachydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13522",
    "question": "What is associated with Renal coloboma syndrome?",
    "seeds": [
      "Renal coloboma syndrome"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13523",
    "question": "What is associated with Purulent sputum?",
    "seeds": [
      "Purulent sputum"
    ],
    "gold_answer": "Abnormal sputum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13524",
    "question": "What is associated with Foix-Chavany-Marie syndrome?",
    "seeds": [
      "Foix-Chavany-Marie syndrome"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13525",
    "question": "What phenotype is associated with Neuralgic amyotrophy?",
    "seeds": [
      "Neuralgic amyotrophy"
    ],
    "gold_answer": "Hypoesthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13526",
    "question": "What phenotype is associated with Congenital myopathy 5 with cardiomyopathy?",
    "seeds": [
      "Congenital myopathy 5 with cardiomyopathy"
    ],
    "gold_answer": "Difficulty running",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13527",
    "question": "What is associated with Basal ganglia cysts?",
    "seeds": [
      "Basal ganglia cysts"
    ],
    "gold_answer": "Abnormal basal ganglia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13528",
    "question": "What is associated with Scapular aplasia?",
    "seeds": [
      "Scapular aplasia"
    ],
    "gold_answer": "Aplasia/hypoplasia affecting bones of the axial skeleton",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13529",
    "question": "What is associated with Renal cortical interstitial inflammation?",
    "seeds": [
      "Renal cortical interstitial inflammation"
    ],
    "gold_answer": "Abnormal renal interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13530",
    "question": "What is associated with Cone-shaped epiphyses of the 5th toe?",
    "seeds": [
      "Cone-shaped epiphyses of the 5th toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13531",
    "question": "What is associated with Diminished glomerular basement membrane collagen IV alpha 5 chain staining?",
    "seeds": [
      "Diminished glomerular basement membrane collagen IV alpha 5 chain staining"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13532",
    "question": "What is associated with DEFECTIVE INTERFERING PARTICLE INDUCTION, CONTROL OF?",
    "seeds": [
      "DEFECTIVE INTERFERING PARTICLE INDUCTION, CONTROL OF"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13533",
    "question": "What is associated with MEHMO syndrome?",
    "seeds": [
      "MEHMO syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13534",
    "question": "What is associated with Hypothyroidism, central, and testicular enlargement?",
    "seeds": [
      "Hypothyroidism, central, and testicular enlargement"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13535",
    "question": "What is associated with Abnormally rapid thought process?",
    "seeds": [
      "Abnormally rapid thought process"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13536",
    "question": "What is associated with Neuropathy, hereditary sensory, type IF?",
    "seeds": [
      "Neuropathy, hereditary sensory, type IF"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13537",
    "question": "What phenotype is associated with Immunodeficiency 17?",
    "seeds": [
      "Immunodeficiency 17"
    ],
    "gold_answer": "Hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13538",
    "question": "What is associated with Complete duplication of the distal phalanx of the 4th toe?",
    "seeds": [
      "Complete duplication of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13539",
    "question": "What is associated with Anterior chamber cyst?",
    "seeds": [
      "Anterior chamber cyst"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13540",
    "question": "What is associated with Cardiac teratoma?",
    "seeds": [
      "Cardiac teratoma"
    ],
    "gold_answer": "Embryonal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13541",
    "question": "What is associated with Vascular granular osmiophilic material deposition?",
    "seeds": [
      "Vascular granular osmiophilic material deposition"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13542",
    "question": "What is associated with Skin dimple?",
    "seeds": [
      "Skin dimple"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13543",
    "question": "What is associated with Starch intolerance?",
    "seeds": [
      "Starch intolerance"
    ],
    "gold_answer": "Malabsorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13544",
    "question": "What phenotype is associated with Spermatogenic failure, X-linked, 6?",
    "seeds": [
      "Spermatogenic failure, X-linked, 6"
    ],
    "gold_answer": "Microcephalic sperm head",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13545",
    "question": "What is associated with White lesion of the oral mucosa?",
    "seeds": [
      "White lesion of the oral mucosa"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13546",
    "question": "What is associated with Arthralgia/arthritis?",
    "seeds": [
      "Arthralgia/arthritis"
    ],
    "gold_answer": "Arthralgia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13547",
    "question": "What is associated with Albinism, oculocutaneous, type IB?",
    "seeds": [
      "Albinism, oculocutaneous, type IB"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13548",
    "question": "What is associated with Reduced epidermal keratin 10 protein expression?",
    "seeds": [
      "Reduced epidermal keratin 10 protein expression"
    ],
    "gold_answer": "Reduced epidermal keratin protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13549",
    "question": "What is associated with Dystonia 9?",
    "seeds": [
      "Dystonia 9"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13550",
    "question": "What is associated with Histiocytoma, angiomatoid fibrous, somatic?",
    "seeds": [
      "Histiocytoma, angiomatoid fibrous, somatic"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13551",
    "question": "What is associated with Positive nasopharyngeal corynebacterium diphtheriae nucleic acid test?",
    "seeds": [
      "Positive nasopharyngeal corynebacterium diphtheriae nucleic acid test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13552",
    "question": "What is associated with Increased erythrocyte coproporphyrin concentration?",
    "seeds": [
      "Increased erythrocyte coproporphyrin concentration"
    ],
    "gold_answer": "Elevated circulating porphyrin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13553",
    "question": "What is associated with Conjunctival amyloidosis?",
    "seeds": [
      "Conjunctival amyloidosis"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13554",
    "question": "What is associated with Friedreich ataxia?",
    "seeds": [
      "Friedreich ataxia"
    ],
    "gold_answer": "Peripheral axonal neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13555",
    "question": "What is associated with Familial scaphocephaly syndrome, McGillivray type?",
    "seeds": [
      "Familial scaphocephaly syndrome, McGillivray type"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13556",
    "question": "What phenotype is associated with Nephronophthisis-Like nephropathy 1?",
    "seeds": [
      "Nephronophthisis-Like nephropathy 1"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13557",
    "question": "What phenotype is associated with Spastic paraplegia 70, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 70, autosomal recessive"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13558",
    "question": "What is associated with CSF lymphocytic pleiocytosis?",
    "seeds": [
      "CSF lymphocytic pleiocytosis"
    ],
    "gold_answer": "CSF pleocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13559",
    "question": "What is associated with Cowchock syndrome?",
    "seeds": [
      "Cowchock syndrome"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13560",
    "question": "What is associated with Hypoplasia of the ciliary body?",
    "seeds": [
      "Hypoplasia of the ciliary body"
    ],
    "gold_answer": "Abnormal uvea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13561",
    "question": "What is associated with Elevated circulating sCD25 concentration?",
    "seeds": [
      "Elevated circulating sCD25 concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13562",
    "question": "What phenotype is associated with Dyskeratosis congenita, autosomal recessive 8?",
    "seeds": [
      "Dyskeratosis congenita, autosomal recessive 8"
    ],
    "gold_answer": "Decreased total B cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13563",
    "question": "What is associated with Exposure to oily lotions or creams?",
    "seeds": [
      "Exposure to oily lotions or creams"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13564",
    "question": "What is associated with Supravalvar pulmonary stenosis?",
    "seeds": [
      "Supravalvar pulmonary stenosis"
    ],
    "gold_answer": "Abnormal pulmonary valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13565",
    "question": "What is associated with Excessive insulin response to glucagon test?",
    "seeds": [
      "Excessive insulin response to glucagon test"
    ],
    "gold_answer": "Abnormal response to endocrine stimulation test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13566",
    "question": "What is associated with Brittle cornea syndrome?",
    "seeds": [
      "Brittle cornea syndrome"
    ],
    "gold_answer": "Abnormal hip joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13567",
    "question": "What is associated with Hyperostosis?",
    "seeds": [
      "Hyperostosis"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13568",
    "question": "What is associated with Spastic paraplegia 17?",
    "seeds": [
      "Spastic paraplegia 17"
    ],
    "gold_answer": "Distal upper limb amyotrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13569",
    "question": "What is associated with Longitudinal vaginal septum?",
    "seeds": [
      "Longitudinal vaginal septum"
    ],
    "gold_answer": "Septate vagina",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13570",
    "question": "What is associated with Abnormal microglia morphology?",
    "seeds": [
      "Abnormal microglia morphology"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13571",
    "question": "What is associated with Postaxial hand polydactyly?",
    "seeds": [
      "Postaxial hand polydactyly"
    ],
    "gold_answer": "Duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13572",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 69?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 69"
    ],
    "gold_answer": "Bilateral tonic-clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13573",
    "question": "What is associated with Abnormality of nasalis muscle?",
    "seeds": [
      "Abnormality of nasalis muscle"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13574",
    "question": "What is associated with Hypocalcification of dental enamel?",
    "seeds": [
      "Hypocalcification of dental enamel"
    ],
    "gold_answer": "Abnormal dental enamel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13575",
    "question": "What is associated with Decreased level of 1,5 anhydroglucitol in serum?",
    "seeds": [
      "Decreased level of 1,5 anhydroglucitol in serum"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13576",
    "question": "What is associated with Alpha-N-acetylgalactosaminidase deficiency type 1?",
    "seeds": [
      "Alpha-N-acetylgalactosaminidase deficiency type 1"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13577",
    "question": "What is associated with Aplasia/Hypoplasia involving the musculature of the upper limbs?",
    "seeds": [
      "Aplasia/Hypoplasia involving the musculature of the upper limbs"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the skeletal musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13578",
    "question": "What is associated with Nevus anemicus?",
    "seeds": [
      "Nevus anemicus"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13579",
    "question": "What is associated with With the rule astigmatism?",
    "seeds": [
      "With the rule astigmatism"
    ],
    "gold_answer": "Astigmatism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13580",
    "question": "What is associated with Abnormal HDL3b concentration?",
    "seeds": [
      "Abnormal HDL3b concentration"
    ],
    "gold_answer": "Abnormal HDL cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13581",
    "question": "What is associated with Ventricular fibrillation, familial, 1?",
    "seeds": [
      "Ventricular fibrillation, familial, 1"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13582",
    "question": "What is associated with Thyroidization-type tubular atrophy?",
    "seeds": [
      "Thyroidization-type tubular atrophy"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13583",
    "question": "What is associated with Quotidian fever?",
    "seeds": [
      "Quotidian fever"
    ],
    "gold_answer": "Recurrent fever",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13584",
    "question": "What is associated with Lip telangiectasia?",
    "seeds": [
      "Lip telangiectasia"
    ],
    "gold_answer": "Telangiectasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13585",
    "question": "What is associated with Elevated circulating 3-hydroxyanthranilic acid concentration?",
    "seeds": [
      "Elevated circulating 3-hydroxyanthranilic acid concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13586",
    "question": "What is associated with Elevated brain glycine level by MRS?",
    "seeds": [
      "Elevated brain glycine level by MRS"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13587",
    "question": "What is associated with Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies?",
    "seeds": [
      "Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13588",
    "question": "What is associated with Polycystic kidney dysplasia?",
    "seeds": [
      "Polycystic kidney dysplasia"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13589",
    "question": "What is associated with Mitochondrial complex III deficiency, nuclear type 3?",
    "seeds": [
      "Mitochondrial complex III deficiency, nuclear type 3"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13590",
    "question": "What is associated with Hypoketotic hypoglycemia?",
    "seeds": [
      "Hypoketotic hypoglycemia"
    ],
    "gold_answer": "Hypoglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13591",
    "question": "What phenotype is associated with Nail disorder, nonsyndromic congenital, 5?",
    "seeds": [
      "Nail disorder, nonsyndromic congenital, 5"
    ],
    "gold_answer": "Palmoplantar hyperhidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13592",
    "question": "What phenotype is associated with Sarcoidosis, susceptibility to, 2?",
    "seeds": [
      "Sarcoidosis, susceptibility to, 2"
    ],
    "gold_answer": "Pulmonary fibrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13593",
    "question": "What is associated with Popliteal pterygium?",
    "seeds": [
      "Popliteal pterygium"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13594",
    "question": "What is associated with Spastic paraplegia 28, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 28, autosomal recessive"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13595",
    "question": "What is associated with Auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome?",
    "seeds": [
      "Auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13596",
    "question": "What is associated with Recurrent infantile hypoglycemia?",
    "seeds": [
      "Recurrent infantile hypoglycemia"
    ],
    "gold_answer": "Abnormal blood glucose concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13597",
    "question": "What is associated with Affective epileptic aura?",
    "seeds": [
      "Affective epileptic aura"
    ],
    "gold_answer": "Psychic epileptic aura",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13598",
    "question": "What is associated with Breath-holding spell?",
    "seeds": [
      "Breath-holding spell"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13599",
    "question": "What is associated with Bardet-Biedl syndrome 16?",
    "seeds": [
      "Bardet-Biedl syndrome 16"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13600",
    "question": "What is associated with Aplasia/Hypoplasia of the quadriceps?",
    "seeds": [
      "Aplasia/Hypoplasia of the quadriceps"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the musculature of the thigh",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13601",
    "question": "What is associated with Abnormal circulating threonine concentration?",
    "seeds": [
      "Abnormal circulating threonine concentration"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13602",
    "question": "What is associated with Neuropathy, hereditary motor and sensory, Okinawa type?",
    "seeds": [
      "Neuropathy, hereditary motor and sensory, Okinawa type"
    ],
    "gold_answer": "Tetraplegia/tetraparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13603",
    "question": "What is associated with Renal diverticulum?",
    "seeds": [
      "Renal diverticulum"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13604",
    "question": "What phenotype is associated with Dystonia 4, torsion, autosomal dominant?",
    "seeds": [
      "Dystonia 4, torsion, autosomal dominant"
    ],
    "gold_answer": "Torticollis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13605",
    "question": "What is associated with Irregular radial epiphyses?",
    "seeds": [
      "Irregular radial epiphyses"
    ],
    "gold_answer": "Irregular epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13606",
    "question": "What is associated with Diminishment of comfort with casual physical contact?",
    "seeds": [
      "Diminishment of comfort with casual physical contact"
    ],
    "gold_answer": "Abnormal change in social behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13607",
    "question": "What is associated with HbC hemoglobin?",
    "seeds": [
      "HbC hemoglobin"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13608",
    "question": "What phenotype is associated with Toe, rotated fifth?",
    "seeds": [
      "Toe, rotated fifth"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13609",
    "question": "What is associated with Pendulous urethral stricture?",
    "seeds": [
      "Pendulous urethral stricture"
    ],
    "gold_answer": "Urethral stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13610",
    "question": "What is associated with Anti-thyroglobulin antibody positivity?",
    "seeds": [
      "Anti-thyroglobulin antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13611",
    "question": "What phenotype is associated with Bardet-Biedl syndrome 8?",
    "seeds": [
      "Bardet-Biedl syndrome 8"
    ],
    "gold_answer": "Intestinal malrotation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13612",
    "question": "What is associated with Osteochondrodysplasia, brachydactyly, and overlapping malformed digits?",
    "seeds": [
      "Osteochondrodysplasia, brachydactyly, and overlapping malformed digits"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13613",
    "question": "What is associated with Thoracic platyspondyly?",
    "seeds": [
      "Thoracic platyspondyly"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13614",
    "question": "What phenotype is associated with 13q12.3 microdeletion syndrome?",
    "seeds": [
      "13q12.3 microdeletion syndrome"
    ],
    "gold_answer": "Camptodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13615",
    "question": "What is associated with Breast myxoma?",
    "seeds": [
      "Breast myxoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13616",
    "question": "What is associated with Spastic paraplegia-severe developmental delay-epilepsy syndrome?",
    "seeds": [
      "Spastic paraplegia-severe developmental delay-epilepsy syndrome"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13617",
    "question": "What is associated with Upper-body predominance?",
    "seeds": [
      "Upper-body predominance"
    ],
    "gold_answer": "Localized",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13618",
    "question": "What phenotype is associated with Lamb-Shaffer syndrome?",
    "seeds": [
      "Lamb-Shaffer syndrome"
    ],
    "gold_answer": "Wide nasal bridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13619",
    "question": "What is associated with Punctal stenosis?",
    "seeds": [
      "Punctal stenosis"
    ],
    "gold_answer": "Abnormal nasolacrimal system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13620",
    "question": "What is associated with Cerebral autosomal dominant arteriopathy-subcortical infarcts-leukoencephalopathy?",
    "seeds": [
      "Cerebral autosomal dominant arteriopathy-subcortical infarcts-leukoencephalopathy"
    ],
    "gold_answer": "Impairment in personality functioning",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13621",
    "question": "What is associated with Scaling skin?",
    "seeds": [
      "Scaling skin"
    ],
    "gold_answer": "Abnormal epidermal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13622",
    "question": "What phenotype is associated with Neuropathy, hereditary motor, with myopathic features?",
    "seeds": [
      "Neuropathy, hereditary motor, with myopathic features"
    ],
    "gold_answer": "Distal upper limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13623",
    "question": "What is associated with Isolated lissencephaly type 1 without known genetic defects?",
    "seeds": [
      "Isolated lissencephaly type 1 without known genetic defects"
    ],
    "gold_answer": "Abnormal cerebral ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13624",
    "question": "What is associated with Spondyloenchondrodysplasia?",
    "seeds": [
      "Spondyloenchondrodysplasia"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13625",
    "question": "What is associated with Loeys-Dietz syndrome 5?",
    "seeds": [
      "Loeys-Dietz syndrome 5"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13626",
    "question": "What is associated with Neurodevelopmental disorder with seizures and gingival overgrowth?",
    "seeds": [
      "Neurodevelopmental disorder with seizures and gingival overgrowth"
    ],
    "gold_answer": "Interictal EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13627",
    "question": "What is associated with Abnormal level of lymph-node cellular CD20 expression?",
    "seeds": [
      "Abnormal level of lymph-node cellular CD20 expression"
    ],
    "gold_answer": "Abnormal lymph-node cellular antigen expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13628",
    "question": "What is associated with Frontomalar faciosynostosis?",
    "seeds": [
      "Frontomalar faciosynostosis"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13629",
    "question": "What is associated with Osteocraniostenosis?",
    "seeds": [
      "Osteocraniostenosis"
    ],
    "gold_answer": "FAM111A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13630",
    "question": "What is associated with Hypoplastic philtrum?",
    "seeds": [
      "Hypoplastic philtrum"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13631",
    "question": "What is associated with Premature arteriosclerosis?",
    "seeds": [
      "Premature arteriosclerosis"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13632",
    "question": "What is associated with Calcium nephrolithiasis?",
    "seeds": [
      "Calcium nephrolithiasis"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13633",
    "question": "What is associated with Spermatogenic failure, Y-linked, 1?",
    "seeds": [
      "Spermatogenic failure, Y-linked, 1"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13634",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 11?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 11"
    ],
    "gold_answer": "Abnormal ureter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13635",
    "question": "What is associated with Triggered by vestibular stimulation?",
    "seeds": [
      "Triggered by vestibular stimulation"
    ],
    "gold_answer": "Triggered by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13636",
    "question": "What is associated with Humeral cortical thinning?",
    "seeds": [
      "Humeral cortical thinning"
    ],
    "gold_answer": "Abnormal bone structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13637",
    "question": "What phenotype is associated with Paramyotonia congenita of Von Eulenburg?",
    "seeds": [
      "Paramyotonia congenita of Von Eulenburg"
    ],
    "gold_answer": "Dysphagia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13638",
    "question": "What is associated with Myeloschisis?",
    "seeds": [
      "Myeloschisis"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13639",
    "question": "What is associated with Abnormal lymph-node cellular finding?",
    "seeds": [
      "Abnormal lymph-node cellular finding"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13640",
    "question": "What phenotype is associated with Apparent mineralocorticoid excess?",
    "seeds": [
      "Apparent mineralocorticoid excess"
    ],
    "gold_answer": "Renal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13641",
    "question": "What is associated with Hereditary butyrylcholinesterase deficiency?",
    "seeds": [
      "Hereditary butyrylcholinesterase deficiency"
    ],
    "gold_answer": "Respiratory insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13642",
    "question": "What is associated with Shukla-Vernon syndrome?",
    "seeds": [
      "Shukla-Vernon syndrome"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13643",
    "question": "What is associated with Positive blood barbiturate test?",
    "seeds": [
      "Positive blood barbiturate test"
    ],
    "gold_answer": "Blood xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13644",
    "question": "What is associated with Chronic granulomatous disease 5, autosomal recessive?",
    "seeds": [
      "Chronic granulomatous disease 5, autosomal recessive"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13645",
    "question": "What is associated with Stenosis of the external auditory canal?",
    "seeds": [
      "Stenosis of the external auditory canal"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13646",
    "question": "What is associated with Basal ganglia calcification?",
    "seeds": [
      "Basal ganglia calcification"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13647",
    "question": "What is associated with Michaelis-Gutmann bodies?",
    "seeds": [
      "Michaelis-Gutmann bodies"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13648",
    "question": "What is associated with Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia?",
    "seeds": [
      "Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia"
    ],
    "gold_answer": "Delayed gross motor development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13649",
    "question": "What is associated with Hypomelanotic macule?",
    "seeds": [
      "Hypomelanotic macule"
    ],
    "gold_answer": "Hypopigmented macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13650",
    "question": "What is associated with Protuberant abdomen?",
    "seeds": [
      "Protuberant abdomen"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13651",
    "question": "What is associated with Anteverted nares?",
    "seeds": [
      "Anteverted nares"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13652",
    "question": "What is associated with Galactose mutarotase deficiency?",
    "seeds": [
      "Galactose mutarotase deficiency"
    ],
    "gold_answer": "Abnormal hepatobiliary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13653",
    "question": "What is associated with Medulloepithelioma?",
    "seeds": [
      "Medulloepithelioma"
    ],
    "gold_answer": "Central primitive neuroectodermal tumor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13654",
    "question": "What is associated with Underdeveloped crus of the helix?",
    "seeds": [
      "Underdeveloped crus of the helix"
    ],
    "gold_answer": "Abnormal helix morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13655",
    "question": "What is associated with Exercise-induced myalgia?",
    "seeds": [
      "Exercise-induced myalgia"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13656",
    "question": "What is associated with Abnormal metabolism?",
    "seeds": [
      "Abnormal metabolism"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13657",
    "question": "What is associated with Galloway-Mowat syndrome 2, X-linked?",
    "seeds": [
      "Galloway-Mowat syndrome 2, X-linked"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13658",
    "question": "What is associated with Elevated urinary vanillactic acid level?",
    "seeds": [
      "Elevated urinary vanillactic acid level"
    ],
    "gold_answer": "Abnormal urine carboxylic acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13659",
    "question": "What is associated with Focal aware cognitive seizure?",
    "seeds": [
      "Focal aware cognitive seizure"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13660",
    "question": "What is associated with Olanzapine exposure?",
    "seeds": [
      "Olanzapine exposure"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13661",
    "question": "What is associated with Abnormal T cell physiology?",
    "seeds": [
      "Abnormal T cell physiology"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13662",
    "question": "What is associated with Abdominal obesity-metabolic syndrome 1?",
    "seeds": [
      "Abdominal obesity-metabolic syndrome 1"
    ],
    "gold_answer": "Obesity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13663",
    "question": "What phenotype is associated with Developmental delay, hypotonia, and impaired language?",
    "seeds": [
      "Developmental delay, hypotonia, and impaired language"
    ],
    "gold_answer": "Laryngeal cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13664",
    "question": "What is associated with Renal cortical microcysts?",
    "seeds": [
      "Renal cortical microcysts"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13665",
    "question": "What is associated with Absent Birbeck granules in Langerhans cells?",
    "seeds": [
      "Absent Birbeck granules in Langerhans cells"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13666",
    "question": "What is associated with Recurrent hypoglycemia?",
    "seeds": [
      "Recurrent hypoglycemia"
    ],
    "gold_answer": "Abnormal blood glucose concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13667",
    "question": "What is associated with Unlayered lissencephaly?",
    "seeds": [
      "Unlayered lissencephaly"
    ],
    "gold_answer": "Abnormal cortical gyration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13668",
    "question": "What is associated with Very frequent?",
    "seeds": [
      "Very frequent"
    ],
    "gold_answer": "Frequency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13669",
    "question": "What is associated with Absent proximal phalanx of the 3rd toe?",
    "seeds": [
      "Absent proximal phalanx of the 3rd toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13670",
    "question": "What is associated with Aplasia of the 5th finger?",
    "seeds": [
      "Aplasia of the 5th finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13671",
    "question": "What is associated with Contracture of the proximal interphalangeal joint of the 4th toe?",
    "seeds": [
      "Contracture of the proximal interphalangeal joint of the 4th toe"
    ],
    "gold_answer": "Flexion contracture of digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13672",
    "question": "What is associated with Abnormal cell morphology?",
    "seeds": [
      "Abnormal cell morphology"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13673",
    "question": "What is associated with Foot osteomyelitis?",
    "seeds": [
      "Foot osteomyelitis"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13674",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 33?",
    "seeds": [
      "Ciliary dyskinesia, primary, 33"
    ],
    "gold_answer": "Recurrent otitis media",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13675",
    "question": "What is associated with Cerebral hyaline bodies?",
    "seeds": [
      "Cerebral hyaline bodies"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13676",
    "question": "What phenotype is associated with Encephalopathy due to prosaposin deficiency?",
    "seeds": [
      "Encephalopathy due to prosaposin deficiency"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13677",
    "question": "What is associated with Urethritis?",
    "seeds": [
      "Urethritis"
    ],
    "gold_answer": "Abnormality of the urinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13678",
    "question": "What is associated with Fragmented sleep?",
    "seeds": [
      "Fragmented sleep"
    ],
    "gold_answer": "Poor sleep",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13679",
    "question": "What is associated with Bjornstad syndrome?",
    "seeds": [
      "Bjornstad syndrome"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13680",
    "question": "What is associated with EEG with hyperventilation-induced generalized epileptiform discharges?",
    "seeds": [
      "EEG with hyperventilation-induced generalized epileptiform discharges"
    ],
    "gold_answer": "EEG with hyperventilation-induced epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13681",
    "question": "What is associated with Retinal gliosis?",
    "seeds": [
      "Retinal gliosis"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13682",
    "question": "What is associated with Floppy infant?",
    "seeds": [
      "Floppy infant"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13683",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 33?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 33"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13684",
    "question": "What is associated with Frontal cortical localization?",
    "seeds": [
      "Frontal cortical localization"
    ],
    "gold_answer": "Brain localization",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13685",
    "question": "What is associated with Increased incisura length?",
    "seeds": [
      "Increased incisura length"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13686",
    "question": "What phenotype is associated with Deafness, autosomal recessive 118, with cochlear aplasia?",
    "seeds": [
      "Deafness, autosomal recessive 118, with cochlear aplasia"
    ],
    "gold_answer": "Congenital sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13687",
    "question": "What phenotype is associated with Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity?",
    "seeds": [
      "Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13688",
    "question": "What is associated with Corticospinal tract hypoplasia?",
    "seeds": [
      "Corticospinal tract hypoplasia"
    ],
    "gold_answer": "Abnormal corticospinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13689",
    "question": "What is associated with CTCF-related neurodevelopmental disorder?",
    "seeds": [
      "CTCF-related neurodevelopmental disorder"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13690",
    "question": "What is associated with Obesity due to congenital leptin deficiency?",
    "seeds": [
      "Obesity due to congenital leptin deficiency"
    ],
    "gold_answer": "Abnormality of skeletal maturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13691",
    "question": "What is associated with Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome?",
    "seeds": [
      "Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome"
    ],
    "gold_answer": "Abnormal optic disc morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13692",
    "question": "What phenotype is associated with Night blindness, congenital stationary, type 1A?",
    "seeds": [
      "Night blindness, congenital stationary, type 1A"
    ],
    "gold_answer": "Early-onset non-progressive night blindness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13693",
    "question": "What phenotype is associated with Spinocerebellar ataxia, autosomal recessive 7?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 7"
    ],
    "gold_answer": "Postural tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13694",
    "question": "What is associated with Elevated circulating dihydroxyphenylacetic acid concentration?",
    "seeds": [
      "Elevated circulating dihydroxyphenylacetic acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic amino compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13695",
    "question": "What is associated with Elejalde disease?",
    "seeds": [
      "Elejalde disease"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13696",
    "question": "What phenotype is associated with Basilar impression, primary?",
    "seeds": [
      "Basilar impression, primary"
    ],
    "gold_answer": "Cervical myelopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13697",
    "question": "What phenotype is associated with Renal cysts and diabetes syndrome?",
    "seeds": [
      "Renal cysts and diabetes syndrome"
    ],
    "gold_answer": "Unilateral renal agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13698",
    "question": "What phenotype is associated with Nabais Sa-de vries syndrome, type 2?",
    "seeds": [
      "Nabais Sa-de vries syndrome, type 2"
    ],
    "gold_answer": "Depressed nasal bridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13699",
    "question": "What phenotype is associated with Czech dysplasia, Metatarsal type?",
    "seeds": [
      "Czech dysplasia, Metatarsal type"
    ],
    "gold_answer": "Platyspondyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13700",
    "question": "What is associated with Delayed ossification of the hand bones?",
    "seeds": [
      "Delayed ossification of the hand bones"
    ],
    "gold_answer": "Abnormal enchondral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13701",
    "question": "What is associated with Moderate constriction of peripheral visual field?",
    "seeds": [
      "Moderate constriction of peripheral visual field"
    ],
    "gold_answer": "Constriction of peripheral visual field",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13702",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 4?",
    "seeds": [
      "Developmental and epileptic encephalopathy 4"
    ],
    "gold_answer": "Cerebral atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13703",
    "question": "What is associated with Fallopian tube torsion?",
    "seeds": [
      "Fallopian tube torsion"
    ],
    "gold_answer": "Abnormal fallopian tube morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13704",
    "question": "What is associated with Mitchell syndrome?",
    "seeds": [
      "Mitchell syndrome"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13705",
    "question": "What is associated with 3-methylglutaconic aciduria type 8?",
    "seeds": [
      "3-methylglutaconic aciduria type 8"
    ],
    "gold_answer": "HTRA2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13706",
    "question": "What is associated with Carnosinuria?",
    "seeds": [
      "Carnosinuria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13707",
    "question": "What is associated with Abnormality of the epiphysis of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Abnormality of the epiphysis of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal second toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13708",
    "question": "What is associated with Subdural hemorrhage?",
    "seeds": [
      "Subdural hemorrhage"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13709",
    "question": "What is associated with Vertebral hypoplasia with lumbar kyphosis?",
    "seeds": [
      "Vertebral hypoplasia with lumbar kyphosis"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the vertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13710",
    "question": "What is associated with Increased T cell apoptosis?",
    "seeds": [
      "Increased T cell apoptosis"
    ],
    "gold_answer": "Abnormal T cell apoptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13711",
    "question": "What is associated with Hypoactive bowel sounds?",
    "seeds": [
      "Hypoactive bowel sounds"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13712",
    "question": "What is associated with Developmental and epileptic encephalopathy 12?",
    "seeds": [
      "Developmental and epileptic encephalopathy 12"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13713",
    "question": "What phenotype is associated with Gomez-Lopez-Hernandez syndrome?",
    "seeds": [
      "Gomez-Lopez-Hernandez syndrome"
    ],
    "gold_answer": "Opacification of the corneal stroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13714",
    "question": "What is associated with Hereditary butyrylcholinesterase deficiency?",
    "seeds": [
      "Hereditary butyrylcholinesterase deficiency"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13715",
    "question": "What is associated with Predominant small joint localization?",
    "seeds": [
      "Predominant small joint localization"
    ],
    "gold_answer": "Localized",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13716",
    "question": "What is associated with Adult CLN5 disease?",
    "seeds": [
      "Adult CLN5 disease"
    ],
    "gold_answer": "CLN5",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13717",
    "question": "What is associated with Thickened nuchal skin fold?",
    "seeds": [
      "Thickened nuchal skin fold"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13718",
    "question": "What is associated with X-linked lymphoproliferative disease due to SAP deficiency?",
    "seeds": [
      "X-linked lymphoproliferative disease due to SAP deficiency"
    ],
    "gold_answer": "SH2D1A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13719",
    "question": "What is associated with Hemophagocytic syndrome associated with an infection?",
    "seeds": [
      "Hemophagocytic syndrome associated with an infection"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13720",
    "question": "What is associated with Cotard delusion?",
    "seeds": [
      "Cotard delusion"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13721",
    "question": "What is associated with Deafness, autosomal recessive 45?",
    "seeds": [
      "Deafness, autosomal recessive 45"
    ],
    "gold_answer": "Childhood onset sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13722",
    "question": "What is associated with Statin exposure?",
    "seeds": [
      "Statin exposure"
    ],
    "gold_answer": "Medication history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13723",
    "question": "What is associated with Splenic calcification?",
    "seeds": [
      "Splenic calcification"
    ],
    "gold_answer": "Abnormal spleen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13724",
    "question": "What is associated with Right ventricular regional wall motion abnormality?",
    "seeds": [
      "Right ventricular regional wall motion abnormality"
    ],
    "gold_answer": "Abnormal right ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13725",
    "question": "What is associated with Distal radioulnar joint space widening?",
    "seeds": [
      "Distal radioulnar joint space widening"
    ],
    "gold_answer": "Radioulnar dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13726",
    "question": "What phenotype is associated with Hirschsprung disease-type D brachydactyly syndrome?",
    "seeds": [
      "Hirschsprung disease-type D brachydactyly syndrome"
    ],
    "gold_answer": "Hypoplastic fingernail",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13727",
    "question": "What phenotype is associated with Pontocerebellar hypoplasia, type 5?",
    "seeds": [
      "Pontocerebellar hypoplasia, type 5"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13728",
    "question": "What is associated with Elevated urinary formiminoglutamic acid level?",
    "seeds": [
      "Elevated urinary formiminoglutamic acid level"
    ],
    "gold_answer": "Dicarboxylic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13729",
    "question": "What is associated with Undulate ribs?",
    "seeds": [
      "Undulate ribs"
    ],
    "gold_answer": "Abnormal rib cage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13730",
    "question": "What is associated with Abnormal OCT-measured macular thickness?",
    "seeds": [
      "Abnormal OCT-measured macular thickness"
    ],
    "gold_answer": "Abnormal optical coherence tomography",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13731",
    "question": "What is associated with Fractured metaphysis of femur?",
    "seeds": [
      "Fractured metaphysis of femur"
    ],
    "gold_answer": "Long-bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13732",
    "question": "What is associated with Ehlers-Danlos syndrome, kyphoscoliotic type, 1?",
    "seeds": [
      "Ehlers-Danlos syndrome, kyphoscoliotic type, 1"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13733",
    "question": "What is associated with LARYNGOMALACIA?",
    "seeds": [
      "LARYNGOMALACIA"
    ],
    "gold_answer": "Abnormal larynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13734",
    "question": "What phenotype is associated with Cooks syndrome?",
    "seeds": [
      "Cooks syndrome"
    ],
    "gold_answer": "Split hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13735",
    "question": "What is associated with Low-frequency sensorineural hearing impairment?",
    "seeds": [
      "Low-frequency sensorineural hearing impairment"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13736",
    "question": "What is associated with Joint contracture of the hand?",
    "seeds": [
      "Joint contracture of the hand"
    ],
    "gold_answer": "Abnormality of upper limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13737",
    "question": "What is associated with Hereditary steroid-resistant nephrotic syndrome?",
    "seeds": [
      "Hereditary steroid-resistant nephrotic syndrome"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13738",
    "question": "What is associated with Focal impaired awareness cognitive seizure with illusion?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with illusion"
    ],
    "gold_answer": "Focal impaired awareness cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13739",
    "question": "What is associated with Cataract, ataxia, short stature, and impaired intellectual development?",
    "seeds": [
      "Cataract, ataxia, short stature, and impaired intellectual development"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13740",
    "question": "What is associated with Palmoplantar pustulosis?",
    "seeds": [
      "Palmoplantar pustulosis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13741",
    "question": "What is associated with Left unicoronal synostosis?",
    "seeds": [
      "Left unicoronal synostosis"
    ],
    "gold_answer": "Unicoronal synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13742",
    "question": "What phenotype is associated with Radioulnar synostosis-microcephaly-scoliosis syndrome?",
    "seeds": [
      "Radioulnar synostosis-microcephaly-scoliosis syndrome"
    ],
    "gold_answer": "Limited pronation/supination of forearm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13743",
    "question": "What phenotype is associated with Parkinson disease 15, autosomal recessive?",
    "seeds": [
      "Parkinson disease 15, autosomal recessive"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13744",
    "question": "What is associated with Abnormal Descemet membrane morphology?",
    "seeds": [
      "Abnormal Descemet membrane morphology"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13745",
    "question": "What is associated with Ventral hernia?",
    "seeds": [
      "Ventral hernia"
    ],
    "gold_answer": "Hernia of the abdominal wall",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13746",
    "question": "What is associated with Hypoplastic areola?",
    "seeds": [
      "Hypoplastic areola"
    ],
    "gold_answer": "Abnormal breast morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13747",
    "question": "What is associated with Cholestasis, benign recurrent intrahepatic 1?",
    "seeds": [
      "Cholestasis, benign recurrent intrahepatic 1"
    ],
    "gold_answer": "Abnormal circulating bilirubin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13748",
    "question": "What phenotype is associated with Combined oxidative phosphorylation deficiency 23?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 23"
    ],
    "gold_answer": "Hypertrophic cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13749",
    "question": "What phenotype is associated with Diastasis recti and weakness of the linea alba?",
    "seeds": [
      "Diastasis recti and weakness of the linea alba"
    ],
    "gold_answer": "Diastasis recti",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13750",
    "question": "What is associated with Music-induced seizure?",
    "seeds": [
      "Music-induced seizure"
    ],
    "gold_answer": "Reflex seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13751",
    "question": "What is associated with Galloway-Mowat syndrome 8?",
    "seeds": [
      "Galloway-Mowat syndrome 8"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13752",
    "question": "What is associated with Abnormal spinal cord dorsal column morphology?",
    "seeds": [
      "Abnormal spinal cord dorsal column morphology"
    ],
    "gold_answer": "Abnormal spinal cord white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13753",
    "question": "What phenotype is associated with Inflammatory bowel disease 25, early onset, autosomal recessive?",
    "seeds": [
      "Inflammatory bowel disease 25, early onset, autosomal recessive"
    ],
    "gold_answer": "Rectovaginal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13754",
    "question": "What is associated with Choanal atresia and lymphedema?",
    "seeds": [
      "Choanal atresia and lymphedema"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13755",
    "question": "What is associated with Flexion contracture of digit?",
    "seeds": [
      "Flexion contracture of digit"
    ],
    "gold_answer": "Flexion contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13756",
    "question": "What phenotype is associated with Thyroid carcinoma, familial medullary?",
    "seeds": [
      "Thyroid carcinoma, familial medullary"
    ],
    "gold_answer": "Hyperhidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13757",
    "question": "What phenotype is associated with Short-Rib thoracic dysplasia 19 with or without polydactyly?",
    "seeds": [
      "Short-Rib thoracic dysplasia 19 with or without polydactyly"
    ],
    "gold_answer": "Elevated maternal circulating alpha-fetoprotein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13758",
    "question": "What is associated with Testicular fibrosis?",
    "seeds": [
      "Testicular fibrosis"
    ],
    "gold_answer": "Abnormality of the male genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13759",
    "question": "What is associated with Salzmann corneal nodules?",
    "seeds": [
      "Salzmann corneal nodules"
    ],
    "gold_answer": "Corneal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13760",
    "question": "What is associated with Spondyloarthropathy, susceptibility to, 1?",
    "seeds": [
      "Spondyloarthropathy, susceptibility to, 1"
    ],
    "gold_answer": "Abnormal heart valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13761",
    "question": "What is associated with Platyspondylic dysplasia, Torrance type?",
    "seeds": [
      "Platyspondylic dysplasia, Torrance type"
    ],
    "gold_answer": "Abnormal nasal bridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13762",
    "question": "What is associated with ADAR-related hereditary spastic paraplegia?",
    "seeds": [
      "ADAR-related hereditary spastic paraplegia"
    ],
    "gold_answer": "ADAR",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13763",
    "question": "What is associated with Decreased alveolar volume?",
    "seeds": [
      "Decreased alveolar volume"
    ],
    "gold_answer": "Abnormal alveolar volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13764",
    "question": "What is associated with Abnormal male germ cell morphology?",
    "seeds": [
      "Abnormal male germ cell morphology"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13765",
    "question": "What is associated with Flared femoral metaphysis?",
    "seeds": [
      "Flared femoral metaphysis"
    ],
    "gold_answer": "Abnormal lower-limb metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13766",
    "question": "What is associated with Bone marrow failure syndrome 4?",
    "seeds": [
      "Bone marrow failure syndrome 4"
    ],
    "gold_answer": "Limb undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13767",
    "question": "What is associated with Glaucoma 3, primary congenital, E?",
    "seeds": [
      "Glaucoma 3, primary congenital, E"
    ],
    "gold_answer": "Asymmetry of intraocular pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13768",
    "question": "What phenotype is associated with Diarrhea 14, congenital?",
    "seeds": [
      "Diarrhea 14, congenital"
    ],
    "gold_answer": "Dependency on parenteral nutrition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13769",
    "question": "What phenotype is associated with Mitral valve prolapse, myxomatous 3?",
    "seeds": [
      "Mitral valve prolapse, myxomatous 3"
    ],
    "gold_answer": "Mitral regurgitation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13770",
    "question": "What is associated with Robinow-Sorauf syndrome?",
    "seeds": [
      "Robinow-Sorauf syndrome"
    ],
    "gold_answer": "Abnormal midface morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13771",
    "question": "What is associated with Bullous lichen planus?",
    "seeds": [
      "Bullous lichen planus"
    ],
    "gold_answer": "Abnormal breast morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13772",
    "question": "What is associated with S-adenosylhomocysteine hydrolase deficiency?",
    "seeds": [
      "S-adenosylhomocysteine hydrolase deficiency"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13773",
    "question": "What is associated with Duplication of phalanx of 2nd finger?",
    "seeds": [
      "Duplication of phalanx of 2nd finger"
    ],
    "gold_answer": "Hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13774",
    "question": "What is associated with Hyperostosis frontalis interna?",
    "seeds": [
      "Hyperostosis frontalis interna"
    ],
    "gold_answer": "Cranial hyperostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13775",
    "question": "What is associated with Meconium ileus?",
    "seeds": [
      "Meconium ileus"
    ],
    "gold_answer": "Intestinal obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13776",
    "question": "What is associated with Familial pancreatic carcinoma?",
    "seeds": [
      "Familial pancreatic carcinoma"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13777",
    "question": "What phenotype is associated with Spastic paraplegia 25, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 25, autosomal recessive"
    ],
    "gold_answer": "Spastic paraplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13778",
    "question": "What is associated with Ocular albinism with late-onset sensorineural deafness?",
    "seeds": [
      "Ocular albinism with late-onset sensorineural deafness"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13779",
    "question": "What phenotype is associated with Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome?",
    "seeds": [
      "Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13780",
    "question": "What is associated with Abnormal circulating fetuin A concentration?",
    "seeds": [
      "Abnormal circulating fetuin A concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13781",
    "question": "What is associated with Abnormal hair pattern?",
    "seeds": [
      "Abnormal hair pattern"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13782",
    "question": "What is associated with Scleritis?",
    "seeds": [
      "Scleritis"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13783",
    "question": "What is associated with Increased serum estradiol?",
    "seeds": [
      "Increased serum estradiol"
    ],
    "gold_answer": "Abnormal serum estradiol",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13784",
    "question": "What is associated with Atypical absence status epilepticus?",
    "seeds": [
      "Atypical absence status epilepticus"
    ],
    "gold_answer": "Non-convulsive status epilepticus without coma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13785",
    "question": "What is associated with Ultra-low vision?",
    "seeds": [
      "Ultra-low vision"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13786",
    "question": "What is associated with Absent epiphysis of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Absent epiphysis of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Absent epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13787",
    "question": "What is associated with Peripheral neuropathy, myopathy, hoarseness, and hearing loss?",
    "seeds": [
      "Peripheral neuropathy, myopathy, hoarseness, and hearing loss"
    ],
    "gold_answer": "Somatic sensory dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13788",
    "question": "What is associated with Generalized hirsutism?",
    "seeds": [
      "Generalized hirsutism"
    ],
    "gold_answer": "Abnormal hair quantity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13789",
    "question": "What is associated with Abnormality of the pancreatic islet cells?",
    "seeds": [
      "Abnormality of the pancreatic islet cells"
    ],
    "gold_answer": "Abnormality of pancreas physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13790",
    "question": "What is associated with Abnormality of the distal phalanx of the hallux?",
    "seeds": [
      "Abnormality of the distal phalanx of the hallux"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13791",
    "question": "What is associated with Brachioradialis hyporeflexia?",
    "seeds": [
      "Brachioradialis hyporeflexia"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13792",
    "question": "What is associated with Abnormal circulating keto acid concentration?",
    "seeds": [
      "Abnormal circulating keto acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13793",
    "question": "What phenotype is associated with Short-Rib thoracic dysplasia 10 with or without polydactyly?",
    "seeds": [
      "Short-Rib thoracic dysplasia 10 with or without polydactyly"
    ],
    "gold_answer": "Cerebellar vermis hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13794",
    "question": "What phenotype is associated with Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder?",
    "seeds": [
      "Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder"
    ],
    "gold_answer": "Intellectual disability, severe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13795",
    "question": "What phenotype is associated with Congenital pulmonary valvar stenosis?",
    "seeds": [
      "Congenital pulmonary valvar stenosis"
    ],
    "gold_answer": "Laryngeal stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13796",
    "question": "What is associated with Nasolacrimal sac granuloma?",
    "seeds": [
      "Nasolacrimal sac granuloma"
    ],
    "gold_answer": "Abnormal lacrimal sac morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13797",
    "question": "What is associated with Functional abnormality of the inner ear?",
    "seeds": [
      "Functional abnormality of the inner ear"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13798",
    "question": "What is associated with Abnormal circulating branched chain amino acid concentration?",
    "seeds": [
      "Abnormal circulating branched chain amino acid concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13799",
    "question": "What is associated with Ph-positive acute lymphoblastic leukemia?",
    "seeds": [
      "Ph-positive acute lymphoblastic leukemia"
    ],
    "gold_answer": "Acute lymphoblastic leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13800",
    "question": "What is associated with Pulp obliteration?",
    "seeds": [
      "Pulp obliteration"
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13801",
    "question": "What is associated with Brain malformation renal syndrome?",
    "seeds": [
      "Brain malformation renal syndrome"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13802",
    "question": "What is associated with Multiple central nervous system lipomas?",
    "seeds": [
      "Multiple central nervous system lipomas"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13803",
    "question": "What is associated with Delayed sleep phase disorder, susceptibility to?",
    "seeds": [
      "Delayed sleep phase disorder, susceptibility to"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13804",
    "question": "What is associated with Pili torti-developmental delay-neurological abnormalities syndrome?",
    "seeds": [
      "Pili torti-developmental delay-neurological abnormalities syndrome"
    ],
    "gold_answer": "Abnormal hairshaft morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13805",
    "question": "What is associated with Metabolic acidosis?",
    "seeds": [
      "Metabolic acidosis"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13806",
    "question": "What is associated with Renal arteriole medial hypertrophy?",
    "seeds": [
      "Renal arteriole medial hypertrophy"
    ],
    "gold_answer": "Abnormal renal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13807",
    "question": "What is associated with Angioid streaks?",
    "seeds": [
      "Angioid streaks"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13808",
    "question": "What is associated with Protoporphyria, erythropoietic, 2?",
    "seeds": [
      "Protoporphyria, erythropoietic, 2"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13809",
    "question": "What phenotype is associated with Craniofacioskeletal syndrome?",
    "seeds": [
      "Craniofacioskeletal syndrome"
    ],
    "gold_answer": "Highly arched eyebrow",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13810",
    "question": "What is associated with Stroke?",
    "seeds": [
      "Stroke"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13811",
    "question": "What is associated with Ring dermoid of cornea?",
    "seeds": [
      "Ring dermoid of cornea"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13812",
    "question": "What is associated with Abnormality of fluid regulation?",
    "seeds": [
      "Abnormality of fluid regulation"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13813",
    "question": "What is associated with Focal aware vocal automatism seizure?",
    "seeds": [
      "Focal aware vocal automatism seizure"
    ],
    "gold_answer": "Focal aware automatism seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13814",
    "question": "What phenotype is associated with Lassa fever?",
    "seeds": [
      "Lassa fever"
    ],
    "gold_answer": "Abdominal pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13815",
    "question": "What is associated with Complete duplication of the phalanges of the 3rd finger?",
    "seeds": [
      "Complete duplication of the phalanges of the 3rd finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13816",
    "question": "What is associated with Bile duct polyp?",
    "seeds": [
      "Bile duct polyp"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13817",
    "question": "What is associated with Glaucoma 1, open angle, P?",
    "seeds": [
      "Glaucoma 1, open angle, P"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13818",
    "question": "What is associated with Canine teeth, absence of upper permanent?",
    "seeds": [
      "Canine teeth, absence of upper permanent"
    ],
    "gold_answer": "Tooth agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13819",
    "question": "What is associated with Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13820",
    "question": "What is associated with Polydactyly affecting the 2nd finger?",
    "seeds": [
      "Polydactyly affecting the 2nd finger"
    ],
    "gold_answer": "Mesoaxial hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13821",
    "question": "What is associated with Joubert syndrome 1?",
    "seeds": [
      "Joubert syndrome 1"
    ],
    "gold_answer": "Meningocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13822",
    "question": "What is associated with Lewy bodies?",
    "seeds": [
      "Lewy bodies"
    ],
    "gold_answer": "Cerebral inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13823",
    "question": "What is associated with Ipsilateral lack of facial sweating?",
    "seeds": [
      "Ipsilateral lack of facial sweating"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13824",
    "question": "What is associated with Fetal onset?",
    "seeds": [
      "Fetal onset"
    ],
    "gold_answer": "Clinical course",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13825",
    "question": "What is associated with Elevated circulating 3-hydroxyisovalerylcarnitine concentration?",
    "seeds": [
      "Elevated circulating 3-hydroxyisovalerylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13826",
    "question": "What is associated with Progressive bowing of long bones?",
    "seeds": [
      "Progressive bowing of long bones"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13827",
    "question": "What is associated with Parosmia?",
    "seeds": [
      "Parosmia"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13828",
    "question": "What is associated with Phacoanaphylactic uveitis?",
    "seeds": [
      "Phacoanaphylactic uveitis"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13829",
    "question": "What is associated with Ossifying fibroma?",
    "seeds": [
      "Ossifying fibroma"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13830",
    "question": "What is associated with History of recent trauma to external ear canal?",
    "seeds": [
      "History of recent trauma to external ear canal"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13831",
    "question": "What is associated with Lichen planopilaris?",
    "seeds": [
      "Lichen planopilaris"
    ],
    "gold_answer": "Hypopigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13832",
    "question": "What is associated with Paroxysmal tachycardia?",
    "seeds": [
      "Paroxysmal tachycardia"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13833",
    "question": "What is associated with Abnormal Humphrey SITA 30-2 perimetry test?",
    "seeds": [
      "Abnormal Humphrey SITA 30-2 perimetry test"
    ],
    "gold_answer": "Abnormal static automated perimetry test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13834",
    "question": "What is associated with Ataxia, sensory, autosomal dominant?",
    "seeds": [
      "Ataxia, sensory, autosomal dominant"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13835",
    "question": "What is associated with Omphalocele?",
    "seeds": [
      "Omphalocele"
    ],
    "gold_answer": "Hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13836",
    "question": "What is associated with Ainhum?",
    "seeds": [
      "Ainhum"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13837",
    "question": "What is associated with Secretory adrenocortical adenoma?",
    "seeds": [
      "Secretory adrenocortical adenoma"
    ],
    "gold_answer": "Neoplasm of the adrenal gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13838",
    "question": "What is associated with Broad nail?",
    "seeds": [
      "Broad nail"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13839",
    "question": "What is associated with Paratracheal lymphadenopathy?",
    "seeds": [
      "Paratracheal lymphadenopathy"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13840",
    "question": "What is associated with Illusions due to affect?",
    "seeds": [
      "Illusions due to affect"
    ],
    "gold_answer": "Abnormal interpretation of external stimuli",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13841",
    "question": "What phenotype is associated with Hypobetalipoproteinemia, familial, 1?",
    "seeds": [
      "Hypobetalipoproteinemia, familial, 1"
    ],
    "gold_answer": "Acanthocytosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13842",
    "question": "What is associated with Increased urinary non-proteinogenic amino acid level?",
    "seeds": [
      "Increased urinary non-proteinogenic amino acid level"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13843",
    "question": "What is associated with Congenital fibrosis of extraocular muscles?",
    "seeds": [
      "Congenital fibrosis of extraocular muscles"
    ],
    "gold_answer": "Focal dystonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13844",
    "question": "What is associated with Triggered by excitement?",
    "seeds": [
      "Triggered by excitement"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13845",
    "question": "What is associated with Keratoconus 8?",
    "seeds": [
      "Keratoconus 8"
    ],
    "gold_answer": "Increased corneal curvature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13846",
    "question": "What phenotype is associated with Avascular necrosis of femoral head, primary, 1?",
    "seeds": [
      "Avascular necrosis of femoral head, primary, 1"
    ],
    "gold_answer": "Avascular necrosis of the capital femoral epiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13847",
    "question": "What is associated with Anemia, autoimmune hemolytic?",
    "seeds": [
      "Anemia, autoimmune hemolytic"
    ],
    "gold_answer": "Anemia due to reduced life span of red cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13848",
    "question": "What is associated with Optic atrophy from cranial nerve compression?",
    "seeds": [
      "Optic atrophy from cranial nerve compression"
    ],
    "gold_answer": "Abnormal cranial nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13849",
    "question": "What is associated with Impaired convulxin-induced platelet aggregation?",
    "seeds": [
      "Impaired convulxin-induced platelet aggregation"
    ],
    "gold_answer": "Impaired platelet aggregation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13850",
    "question": "What phenotype is associated with Spermatogenic failure 78?",
    "seeds": [
      "Spermatogenic failure 78"
    ],
    "gold_answer": "Repeated implantation failure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13851",
    "question": "What is associated with Congenital smooth muscle hamartoma with or without hemihypertrophy?",
    "seeds": [
      "Congenital smooth muscle hamartoma with or without hemihypertrophy"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13852",
    "question": "What is associated with Lissencephaly 9 with complex brainstem malformation?",
    "seeds": [
      "Lissencephaly 9 with complex brainstem malformation"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13853",
    "question": "What is associated with Insulin receptor antibody positivity?",
    "seeds": [
      "Insulin receptor antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13854",
    "question": "What is associated with Multiple cutaneous malignancies?",
    "seeds": [
      "Multiple cutaneous malignancies"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13855",
    "question": "What is associated with Neurodevelopmental disorder with brain anomalies, seizures, and scoliosis?",
    "seeds": [
      "Neurodevelopmental disorder with brain anomalies, seizures, and scoliosis"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13856",
    "question": "What is associated with Eosinophilic microabscess formation in the esophagus?",
    "seeds": [
      "Eosinophilic microabscess formation in the esophagus"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13857",
    "question": "What is associated with Rectal perforation?",
    "seeds": [
      "Rectal perforation"
    ],
    "gold_answer": "Intestinal perforation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13858",
    "question": "What is associated with Profound sensorineural hearing impairment?",
    "seeds": [
      "Profound sensorineural hearing impairment"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13859",
    "question": "What is associated with Abnormal kinin-kallikrein system component activity?",
    "seeds": [
      "Abnormal kinin-kallikrein system component activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13860",
    "question": "What is associated with Osteoarthritis?",
    "seeds": [
      "Osteoarthritis"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13861",
    "question": "What is associated with Pachygyria with 5-10 mm cortical thickness?",
    "seeds": [
      "Pachygyria with 5-10 mm cortical thickness"
    ],
    "gold_answer": "Lissencephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13862",
    "question": "What is associated with Polyclonal elevated circulating IgE concentration?",
    "seeds": [
      "Polyclonal elevated circulating IgE concentration"
    ],
    "gold_answer": "Increased circulating IgE concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13863",
    "question": "What is associated with Enhanced ristocetin cofactor assay activity?",
    "seeds": [
      "Enhanced ristocetin cofactor assay activity"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13864",
    "question": "What is associated with Bardet-Biedl syndrome 21?",
    "seeds": [
      "Bardet-Biedl syndrome 21"
    ],
    "gold_answer": "Hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13865",
    "question": "What phenotype is associated with Kindler epidermolysis bullosa?",
    "seeds": [
      "Kindler epidermolysis bullosa"
    ],
    "gold_answer": "Corneal opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13866",
    "question": "What is associated with Abnormal fetal long-bone echogenicity?",
    "seeds": [
      "Abnormal fetal long-bone echogenicity"
    ],
    "gold_answer": "Fetal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13867",
    "question": "What is associated with Palatal tremor?",
    "seeds": [
      "Palatal tremor"
    ],
    "gold_answer": "Myoclonus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13868",
    "question": "What is associated with Delayed self-feeding during toddler years?",
    "seeds": [
      "Delayed self-feeding during toddler years"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13869",
    "question": "What is associated with Complete duplication of the middle phalanx of the 2nd toe?",
    "seeds": [
      "Complete duplication of the middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Duplication of the middle phalanx of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13870",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanx of the hallux?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanx of the hallux"
    ],
    "gold_answer": "Aplasia/Hypoplasia of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13871",
    "question": "What is associated with Double outlet right ventricle with subaortic ventricular septal defect and pulmonary stenosis?",
    "seeds": [
      "Double outlet right ventricle with subaortic ventricular septal defect and pulmonary stenosis"
    ],
    "gold_answer": "Double outlet right ventricle",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13872",
    "question": "What phenotype is associated with Meckel syndrome?",
    "seeds": [
      "Meckel syndrome"
    ],
    "gold_answer": "Hyposmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13873",
    "question": "What is associated with Epsilon wave?",
    "seeds": [
      "Epsilon wave"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13874",
    "question": "What phenotype is associated with Essential fructosuria?",
    "seeds": [
      "Essential fructosuria"
    ],
    "gold_answer": "Abnormal erythrocyte enzyme activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13875",
    "question": "What is associated with Complete duplication of the distal phalanx of the 4th toe?",
    "seeds": [
      "Complete duplication of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the phalanges of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13876",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 23?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 23"
    ],
    "gold_answer": "Irregular hyperpigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13877",
    "question": "What is associated with Abnormal cardiac catheterization?",
    "seeds": [
      "Abnormal cardiac catheterization"
    ],
    "gold_answer": "Abnormal cardiac test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13878",
    "question": "What is associated with Abnormal periodontium morphology?",
    "seeds": [
      "Abnormal periodontium morphology"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13879",
    "question": "What is associated with Pyriform sperm head?",
    "seeds": [
      "Pyriform sperm head"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13880",
    "question": "What is associated with Large carpal bones?",
    "seeds": [
      "Large carpal bones"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13881",
    "question": "What is associated with Myopathy, myofibrillar, 1?",
    "seeds": [
      "Myopathy, myofibrillar, 1"
    ],
    "gold_answer": "Abnormal cranial nerve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13882",
    "question": "What is associated with Atresia of the external auditory canal?",
    "seeds": [
      "Atresia of the external auditory canal"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13883",
    "question": "What is associated with CIDEC-related familial partial lipodystrophy?",
    "seeds": [
      "CIDEC-related familial partial lipodystrophy"
    ],
    "gold_answer": "Abnormal glucose homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13884",
    "question": "What is associated with Abnormal circulating vitamin B12 concentration?",
    "seeds": [
      "Abnormal circulating vitamin B12 concentration"
    ],
    "gold_answer": "Abnormality of vitamin metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13885",
    "question": "What is associated with CADDS?",
    "seeds": [
      "CADDS"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13886",
    "question": "What is associated with Moderate oligozoospermia?",
    "seeds": [
      "Moderate oligozoospermia"
    ],
    "gold_answer": "Abnormal spermatogenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13887",
    "question": "What phenotype is associated with Familial idiopathic steroid-resistant nephrotic syndrome?",
    "seeds": [
      "Familial idiopathic steroid-resistant nephrotic syndrome"
    ],
    "gold_answer": "Nephrotic syndrome",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13888",
    "question": "What is associated with Prominent crus of helix?",
    "seeds": [
      "Prominent crus of helix"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13889",
    "question": "What is associated with Immunodeficiency due to ficolin 3 deficiency?",
    "seeds": [
      "Immunodeficiency due to ficolin 3 deficiency"
    ],
    "gold_answer": "Colitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13890",
    "question": "What is associated with Renal medullary pyramid hypoplasia?",
    "seeds": [
      "Renal medullary pyramid hypoplasia"
    ],
    "gold_answer": "Abnormal medullary pyramid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13891",
    "question": "What phenotype is associated with Anterior segment dysgenesis 2?",
    "seeds": [
      "Anterior segment dysgenesis 2"
    ],
    "gold_answer": "Ocular hypertension",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13892",
    "question": "What is associated with Renal caliceal diverticuli-deafness syndrome?",
    "seeds": [
      "Renal caliceal diverticuli-deafness syndrome"
    ],
    "gold_answer": "Abnormality of the ureter",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13893",
    "question": "What is associated with Decreased serum thromboxane B2?",
    "seeds": [
      "Decreased serum thromboxane B2"
    ],
    "gold_answer": "Abnormal circulating unsaturated fatty acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13894",
    "question": "What is associated with Agenesis of the small intestine?",
    "seeds": [
      "Agenesis of the small intestine"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13895",
    "question": "What is associated with Migraine, familial typical, susceptibility to, 2?",
    "seeds": [
      "Migraine, familial typical, susceptibility to, 2"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13896",
    "question": "What is associated with Extensor tendons of finger anomalies?",
    "seeds": [
      "Extensor tendons of finger anomalies"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13897",
    "question": "What is associated with Cogwheel rigidity?",
    "seeds": [
      "Cogwheel rigidity"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13898",
    "question": "What is associated with Abolished vibration sense?",
    "seeds": [
      "Abolished vibration sense"
    ],
    "gold_answer": "Impaired vibratory sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13899",
    "question": "What is associated with Hopelessness?",
    "seeds": [
      "Hopelessness"
    ],
    "gold_answer": "Disorder of thought content",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13900",
    "question": "What is associated with Anti-Complement factor H antibody positivity?",
    "seeds": [
      "Anti-Complement factor H antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13901",
    "question": "What is associated with Hypermethioninemia encephalopathy due to adenosine kinase deficiency?",
    "seeds": [
      "Hypermethioninemia encephalopathy due to adenosine kinase deficiency"
    ],
    "gold_answer": "ADK",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_train_13902",
    "question": "What is associated with Aneurysm, intracranial berry, 2?",
    "seeds": [
      "Aneurysm, intracranial berry, 2"
    ],
    "gold_answer": "Abnormal subarachnoid space morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13903",
    "question": "What is associated with Autosomal dominant generalized dystrophic epidermolysis bullosa?",
    "seeds": [
      "Autosomal dominant generalized dystrophic epidermolysis bullosa"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13904",
    "question": "What is associated with Mitral chordae tendinae rupture?",
    "seeds": [
      "Mitral chordae tendinae rupture"
    ],
    "gold_answer": "Abnormal morphology of the chordae tendinae of the mitral valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13905",
    "question": "What is associated with Lecithin:cholesterol acyltransferase deficiency?",
    "seeds": [
      "Lecithin:cholesterol acyltransferase deficiency"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13906",
    "question": "What is associated with Protruding coccyx?",
    "seeds": [
      "Protruding coccyx"
    ],
    "gold_answer": "Abnormal coccyx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13907",
    "question": "What is associated with Mucolipidosis IV?",
    "seeds": [
      "Mucolipidosis IV"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13908",
    "question": "What is associated with Ulnar deviation of the hand?",
    "seeds": [
      "Ulnar deviation of the hand"
    ],
    "gold_answer": "Ulnar deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13909",
    "question": "What phenotype is associated with Spinocerebellar ataxia type 35?",
    "seeds": [
      "Spinocerebellar ataxia type 35"
    ],
    "gold_answer": "Gait ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13910",
    "question": "What is associated with Duplication of metatarsal bones?",
    "seeds": [
      "Duplication of metatarsal bones"
    ],
    "gold_answer": "Duplication involving bones of the feet",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13911",
    "question": "What is associated with Erythematous papule?",
    "seeds": [
      "Erythematous papule"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13912",
    "question": "What is associated with Hurler-Scheie syndrome?",
    "seeds": [
      "Hurler-Scheie syndrome"
    ],
    "gold_answer": "Respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13913",
    "question": "What is associated with Renal tubular epithelial cell simplification?",
    "seeds": [
      "Renal tubular epithelial cell simplification"
    ],
    "gold_answer": "Abnormal renal tubular epithelial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13914",
    "question": "What phenotype is associated with Imagawa-Matsumoto syndrome?",
    "seeds": [
      "Imagawa-Matsumoto syndrome"
    ],
    "gold_answer": "Melanocytic nevus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13915",
    "question": "What is associated with Sclerosis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13916",
    "question": "What phenotype is associated with Mandibulofacial dysostosis-microcephaly syndrome?",
    "seeds": [
      "Mandibulofacial dysostosis-microcephaly syndrome"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13917",
    "question": "What is associated with Abnormal circulating retinol-binding protein concentration?",
    "seeds": [
      "Abnormal circulating retinol-binding protein concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13918",
    "question": "What is associated with Mild global developmental delay?",
    "seeds": [
      "Mild global developmental delay"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13919",
    "question": "What phenotype is associated with Perlman syndrome?",
    "seeds": [
      "Perlman syndrome"
    ],
    "gold_answer": "Abnormal uterus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13920",
    "question": "What phenotype is associated with Cardioneuromyopathy with hyaline masses and nemaline rods?",
    "seeds": [
      "Cardioneuromyopathy with hyaline masses and nemaline rods"
    ],
    "gold_answer": "Respiratory insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13921",
    "question": "What is associated with Abnormal hair whorl?",
    "seeds": [
      "Abnormal hair whorl"
    ],
    "gold_answer": "Congenital abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13922",
    "question": "What is associated with EEG with focal sharp waves?",
    "seeds": [
      "EEG with focal sharp waves"
    ],
    "gold_answer": "EEG with focal epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13923",
    "question": "What is associated with Truncal location?",
    "seeds": [
      "Truncal location"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13924",
    "question": "What is associated with Blunted aldosterone response to aldosterone suppression test?",
    "seeds": [
      "Blunted aldosterone response to aldosterone suppression test"
    ],
    "gold_answer": "Abnormal endocrine physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13925",
    "question": "What is associated with Increased regulatory T cell proportion?",
    "seeds": [
      "Increased regulatory T cell proportion"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13926",
    "question": "What is associated with Hereditary thrombophilia due to congenital antithrombin deficiency?",
    "seeds": [
      "Hereditary thrombophilia due to congenital antithrombin deficiency"
    ],
    "gold_answer": "Splanchnic vein thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13927",
    "question": "What is associated with Large for gestational age?",
    "seeds": [
      "Large for gestational age"
    ],
    "gold_answer": "Increased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13928",
    "question": "What phenotype is associated with Imerslund-Grasbeck syndrome 2?",
    "seeds": [
      "Imerslund-Grasbeck syndrome 2"
    ],
    "gold_answer": "Decreased circulating vitamin B12 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13929",
    "question": "What is associated with Dermal microfilaria?",
    "seeds": [
      "Dermal microfilaria"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13930",
    "question": "What is associated with Compression-fractured cervical vertebra?",
    "seeds": [
      "Compression-fractured cervical vertebra"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13931",
    "question": "What phenotype is associated with Deafness, autosomal dominant 4B?",
    "seeds": [
      "Deafness, autosomal dominant 4B"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13932",
    "question": "What is associated with Hyperchromic macrocytic anemia?",
    "seeds": [
      "Hyperchromic macrocytic anemia"
    ],
    "gold_answer": "Macrocytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13933",
    "question": "What is associated with Absent right superior vena cava?",
    "seeds": [
      "Absent right superior vena cava"
    ],
    "gold_answer": "Abnormal vena cava morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13934",
    "question": "What is associated with Generalized periodontitis?",
    "seeds": [
      "Generalized periodontitis"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13935",
    "question": "What is associated with Myopia 6?",
    "seeds": [
      "Myopia 6"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13936",
    "question": "What phenotype is associated with Hypophosphatasia, infantile?",
    "seeds": [
      "Hypophosphatasia, infantile"
    ],
    "gold_answer": "Elevated plasma pyrophosphate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13937",
    "question": "What is associated with Ingrown nail?",
    "seeds": [
      "Ingrown nail"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13938",
    "question": "What is associated with Redundant umbilical skin?",
    "seeds": [
      "Redundant umbilical skin"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13939",
    "question": "What is associated with Decreased motor nerve conduction velocity?",
    "seeds": [
      "Decreased motor nerve conduction velocity"
    ],
    "gold_answer": "Abnormality of peripheral nerve conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13940",
    "question": "What is associated with Binge drinking?",
    "seeds": [
      "Binge drinking"
    ],
    "gold_answer": "Abnormal alcohol consumption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13941",
    "question": "What is associated with Oocyte/zygote/embryo maturation arrest 20?",
    "seeds": [
      "Oocyte/zygote/embryo maturation arrest 20"
    ],
    "gold_answer": "Decreased fertility in females",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13942",
    "question": "What is associated with Childhood-onset common variable immunodeficiency due to ARHGEF1 deficiency?",
    "seeds": [
      "Childhood-onset common variable immunodeficiency due to ARHGEF1 deficiency"
    ],
    "gold_answer": "ARHGEF1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13943",
    "question": "What is associated with Tetraamelia?",
    "seeds": [
      "Tetraamelia"
    ],
    "gold_answer": "Amelia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13944",
    "question": "What is associated with Increased red cell osmotic resistance?",
    "seeds": [
      "Increased red cell osmotic resistance"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13945",
    "question": "What is associated with Focal cognitive seizure with deja vu/jamais vu?",
    "seeds": [
      "Focal cognitive seizure with deja vu/jamais vu"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13946",
    "question": "What phenotype is associated with Congenital contractural arachnodactyly?",
    "seeds": [
      "Congenital contractural arachnodactyly"
    ],
    "gold_answer": "Arachnodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13947",
    "question": "What is associated with Peripheral neuropathy?",
    "seeds": [
      "Peripheral neuropathy"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13948",
    "question": "What is associated with Abnormal adiponectin level?",
    "seeds": [
      "Abnormal adiponectin level"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13949",
    "question": "What is associated with Autoscopy?",
    "seeds": [
      "Autoscopy"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13950",
    "question": "What is associated with Square humeral metaphysis?",
    "seeds": [
      "Square humeral metaphysis"
    ],
    "gold_answer": "Abnormal humeral metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13951",
    "question": "What is associated with Right ventricular outlet tract obstruction?",
    "seeds": [
      "Right ventricular outlet tract obstruction"
    ],
    "gold_answer": "Abnormal cardiac ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13952",
    "question": "What is associated with Hypnagogic sleep paralysis?",
    "seeds": [
      "Hypnagogic sleep paralysis"
    ],
    "gold_answer": "Sleep paralysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13953",
    "question": "What phenotype is associated with Muscular dystrophy-dystroglycanopathy (congenital without impaired intellectual development), type B, 4?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital without impaired intellectual development), type B, 4"
    ],
    "gold_answer": "Generalized muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13954",
    "question": "What is associated with Chromosome 6q25-q25 deletion syndrome?",
    "seeds": [
      "Chromosome 6q25-q25 deletion syndrome"
    ],
    "gold_answer": "Abnormal tricuspid valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13955",
    "question": "What is associated with Dystonia 33?",
    "seeds": [
      "Dystonia 33"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13956",
    "question": "What is associated with Bone marrow xanthomatosis?",
    "seeds": [
      "Bone marrow xanthomatosis"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13957",
    "question": "What is associated with Paroxysmal nocturnal dyspnea?",
    "seeds": [
      "Paroxysmal nocturnal dyspnea"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13958",
    "question": "What is associated with Impaired renal tubular reabsorption of magnesium?",
    "seeds": [
      "Impaired renal tubular reabsorption of magnesium"
    ],
    "gold_answer": "Abnormal renal tubular resorption",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13959",
    "question": "What phenotype is associated with Waardenburg syndrome, type 4C?",
    "seeds": [
      "Waardenburg syndrome, type 4C"
    ],
    "gold_answer": "Hypopigmented skin patches",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13960",
    "question": "What is associated with Exposure to inhaled lipids?",
    "seeds": [
      "Exposure to inhaled lipids"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13961",
    "question": "What is associated with Cardiac sarcoma?",
    "seeds": [
      "Cardiac sarcoma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13962",
    "question": "What is associated with Presacral teratoma?",
    "seeds": [
      "Presacral teratoma"
    ],
    "gold_answer": "Teratoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13963",
    "question": "What is associated with Abnormal circulating long-chain fatty-acid concentration?",
    "seeds": [
      "Abnormal circulating long-chain fatty-acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13964",
    "question": "What is associated with Myelodysplastic syndrome?",
    "seeds": [
      "Myelodysplastic syndrome"
    ],
    "gold_answer": "TP53",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_train_13965",
    "question": "What is associated with Acute?",
    "seeds": [
      "Acute"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13966",
    "question": "What phenotype is associated with Spastic paraplegia 9B, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 9B, autosomal recessive"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13967",
    "question": "What is associated with Abnormal brain choline/creatine ratio by MRS?",
    "seeds": [
      "Abnormal brain choline/creatine ratio by MRS"
    ],
    "gold_answer": "Abnormal metabolic brain imaging by MRS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13968",
    "question": "What is associated with Dystonic gait?",
    "seeds": [
      "Dystonic gait"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13969",
    "question": "What is associated with Late-onset nephronophthisis?",
    "seeds": [
      "Late-onset nephronophthisis"
    ],
    "gold_answer": "XPNPEP3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13970",
    "question": "What is associated with Abnormality of the distal phalanx of the 4th toe?",
    "seeds": [
      "Abnormality of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13971",
    "question": "What is associated with Short phalanx of the 2nd toe?",
    "seeds": [
      "Short phalanx of the 2nd toe"
    ],
    "gold_answer": "Absent toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13972",
    "question": "What is associated with Cone-shaped epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Cone-shaped epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Cone-shaped epiphyses of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13973",
    "question": "What is associated with Cardiac lipidosis, familial?",
    "seeds": [
      "Cardiac lipidosis, familial"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13974",
    "question": "What is associated with Focal automatism seizure?",
    "seeds": [
      "Focal automatism seizure"
    ],
    "gold_answer": "Focal motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13975",
    "question": "What is associated with Proximal fourth finger symphalangism?",
    "seeds": [
      "Proximal fourth finger symphalangism"
    ],
    "gold_answer": "Proximal finger symphalangism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13976",
    "question": "What is associated with Pachyonychia congenita 4?",
    "seeds": [
      "Pachyonychia congenita 4"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13977",
    "question": "What is associated with Contracture of the distal interphalangeal joint of the 2nd toe?",
    "seeds": [
      "Contracture of the distal interphalangeal joint of the 2nd toe"
    ],
    "gold_answer": "Flexion contracture of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13978",
    "question": "What is associated with Bickerstaff brainstem encephalitis?",
    "seeds": [
      "Bickerstaff brainstem encephalitis"
    ],
    "gold_answer": "Abnormal blood gas level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13979",
    "question": "What is associated with Vein of Galen aneurysmal malformation?",
    "seeds": [
      "Vein of Galen aneurysmal malformation"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13980",
    "question": "What is associated with Idiopathic ventricular fibrillation?",
    "seeds": [
      "Idiopathic ventricular fibrillation"
    ],
    "gold_answer": "SCN5A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13981",
    "question": "What is associated with Glycogen storage disease due to glycogen branching enzyme deficiency, fatal perinatal neuromuscular form?",
    "seeds": [
      "Glycogen storage disease due to glycogen branching enzyme deficiency, fatal perinatal neuromuscular form"
    ],
    "gold_answer": "GBE1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_train_13982",
    "question": "What is associated with Aicardi-Goutieres syndrome 9?",
    "seeds": [
      "Aicardi-Goutieres syndrome 9"
    ],
    "gold_answer": "Abnormal choroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13983",
    "question": "What is associated with Abnormal erythrocyte enzyme concentration or activity?",
    "seeds": [
      "Abnormal erythrocyte enzyme concentration or activity"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13984",
    "question": "What is associated with Small epiphysis of the proximal phalanx of the 5th finger?",
    "seeds": [
      "Small epiphysis of the proximal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13985",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type IIj?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIj"
    ],
    "gold_answer": "Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13986",
    "question": "What is associated with Decreased total B cell count?",
    "seeds": [
      "Decreased total B cell count"
    ],
    "gold_answer": "Abnormal total B cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13987",
    "question": "What is associated with Pigmentary retinopathy?",
    "seeds": [
      "Pigmentary retinopathy"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13988",
    "question": "What phenotype is associated with Early-onset epileptic encephalopathy-cortical blindness-intellectual disability-facial dysmorphism syndrome?",
    "seeds": [
      "Early-onset epileptic encephalopathy-cortical blindness-intellectual disability-facial dysmorphism syndrome"
    ],
    "gold_answer": "Hypsarrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13989",
    "question": "What is associated with Prenatal bowing?",
    "seeds": [
      "Prenatal bowing"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13990",
    "question": "What is associated with Excessive bleeding from superficial cuts?",
    "seeds": [
      "Excessive bleeding from superficial cuts"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13991",
    "question": "What is associated with Duodenal gastric metaplasia?",
    "seeds": [
      "Duodenal gastric metaplasia"
    ],
    "gold_answer": "Abnormal small intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13992",
    "question": "What phenotype is associated with Spermatogenic failure 59?",
    "seeds": [
      "Spermatogenic failure 59"
    ],
    "gold_answer": "Male infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13993",
    "question": "What phenotype is associated with Arteries, anomalies of?",
    "seeds": [
      "Arteries, anomalies of"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_train_13994",
    "question": "What is associated with Abnormal female meiosis?",
    "seeds": [
      "Abnormal female meiosis"
    ],
    "gold_answer": "Abnormal meiosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13995",
    "question": "What is associated with Hypoplasia of olfactory tract?",
    "seeds": [
      "Hypoplasia of olfactory tract"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13996",
    "question": "What is associated with Elevated CSF dihydrobiopterin concentration?",
    "seeds": [
      "Elevated CSF dihydrobiopterin concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13997",
    "question": "What is associated with Anteroposteriorly shortened larynx?",
    "seeds": [
      "Anteroposteriorly shortened larynx"
    ],
    "gold_answer": "Abnormality of the larynx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13998",
    "question": "What is associated with Abnormal ethmoid bone morphology?",
    "seeds": [
      "Abnormal ethmoid bone morphology"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_train_13999",
    "question": "What is associated with Duodenal ulcer?",
    "seeds": [
      "Duodenal ulcer"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  }
]