File size: 6,697 Bytes
4d20b62
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
[
    {
        "sequences": [
            {
                "proteinChain": {
                    "sequence": "YMLDLQPETTDLYCGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH",
                    "count": 1,
                    "msa": {
                        "precomputed_msa_dir": "./examples/7st3/msa/1/",
                        "pairing_db": "uniref100"
                    }
                }
            },
            {
                "proteinChain": {
                    "sequence": "EVKLVESGGGLVQPGGSLRLSCAASGSIFSINTMGWYRQTPGKQRDLVADISSGGSTKYGDSVKGRFTISRDNTKNTVYLQMNSLKPEDTAVYYCYGLSYSNDDYWGQGTQVTVSS",
                    "count": 1,
                    "msa": {
                        "precomputed_msa_dir": "./examples/7st3/msa/2/",
                        "pairing_db": "uniref100"
                    }
                }
            }
        ],
        "modelSeeds": [],
        "name": "7st3_base"
    },
    {
        "sequences": [
            {
                "proteinChain": {
                    "sequence": "YMLDLQPETTDLYCGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH",
                    "count": 1,
                    "msa": {
                        "precomputed_msa_dir": "./examples/7st3/msa/1/",
                        "pairing_db": "uniref100"
                    }
                }
            },
            {
                "proteinChain": {
                    "sequence": "EVKLVESGGGLVQPGGSLRLSCAASGSIFSINTMGWYRQTPGKQRDLVADISSGGSTKYGDSVKGRFTISRDNTKNTVYLQMNSLKPEDTAVYYCYGLSYSNDDYWGQGTQVTVSS",
                    "count": 1,
                    "msa": {
                        "precomputed_msa_dir": "./examples/7st3/msa/2/",
                        "pairing_db": "uniref100"
                    }
                }
            }
        ],
        "modelSeeds": [],
        "name": "7st3_pocket_1_8",
        "constraint": {
            "pocket": {
                "binder_chain": [
                    "2",
                    1
                ],
                "contact_residues": [
                    [
                        "1",
                        1,
                        69
                    ]
                ],
                "max_distance": 8
            }
        }
    },
    {
        "sequences": [
            {
                "proteinChain": {
                    "sequence": "YMLDLQPETTDLYCGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH",
                    "count": 1,
                    "msa": {
                        "precomputed_msa_dir": "./examples/7st3/msa/1/",
                        "pairing_db": "uniref100"
                    }
                }
            },
            {
                "proteinChain": {
                    "sequence": "EVKLVESGGGLVQPGGSLRLSCAASGSIFSINTMGWYRQTPGKQRDLVADISSGGSTKYGDSVKGRFTISRDNTKNTVYLQMNSLKPEDTAVYYCYGLSYSNDDYWGQGTQVTVSS",
                    "count": 1,
                    "msa": {
                        "precomputed_msa_dir": "./examples/7st3/msa/2/",
                        "pairing_db": "uniref100"
                    }
                }
            }
        ],
        "modelSeeds": [],
        "name": "7st3_token_1_15",
        "constraint": {
            "contact": [
                {
                    "residue1": [
                        "1",
                        1,
                        72
                    ],
                    "residue2": [
                        "2",
                        1,
                        103
                    ],
                    "max_distance": 15
                }
            ]
        }
    },
    {
    "sequences": [
      {
        "proteinChain": {
          "sequence": "MSSPLKNALVTAMLAGGALSSPTKQHVGIPVNASPEVGPGKYSFKQVRNPNYKFNGPLSVKKTYLKYGVPIPAWLEDAVQNSTSGLAERSTGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK", 
          "count": 1, 
          "msa": {
            "precomputed_msa_dir": "./examples/5sak/1/", 
            "pairing_db": "uniref100"
          }
        }
      }, 
      {
        "ligand": {"ligand": "CCD_ZRY", "count": 1}
      }
    ], 
    "modelSeeds": [], 
    "name": "5sak_base"
  },
    {
    "sequences": [
      {
        "proteinChain": {
          "sequence": "MSSPLKNALVTAMLAGGALSSPTKQHVGIPVNASPEVGPGKYSFKQVRNPNYKFNGPLSVKKTYLKYGVPIPAWLEDAVQNSTSGLAERSTGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK", 
          "count": 1, 
          "msa": {
            "precomputed_msa_dir": "./examples/5sak/1/", 
            "pairing_db": "uniref100"
          }
        }
      }, 
      {
        "ligand": {"ligand": "CCD_ZRY", "count": 1}
      }
    ], 
    "modelSeeds": [], 
    "name": "5sak_atom_1_3_5", 
    "constraint": {
      "contact": [
        {
          "atom1": ["1", 1, 311, "CG2"], 
          "atom2": ["2", 1, 1, "C10"], 
          "max_distance": 5, 
          "min_distance": 3
        }
      ]
    }
  }

]