File size: 6,848 Bytes
34393ef
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
from sklearn.preprocessing import OneHotEncoder
import logging
import numpy as np
import pandas as pd
import os
import json
import re
import torch
import collections
# from models import reader
from models.ScheduleOptimizer import ScheduledOptim

print(os.path.dirname(__file__))

# ====================|   some path   |=======================
global script_dir
global data_dir
global log_dir
global pth_dir
# global cell_lines

global egfp_seq

with open(os.path.join(os.path.dirname(__file__),"machine_configure.json"),'r') as f:
    config = json.load(f)   

script_dir = config['script_dir']
data_dir = config['data_dir']
log_dir = config['log_dir']
pth_dir = config['pth_dir']



# =====================| one hot encode |=======================

class Seq_one_hot(object):
    def __init__(self,seq_type='nn',seq_len=100):
        """
        initiate the sequence one hot encoder
        """
        self.seq_len=seq_len
        self.seq_type =seq_type
        self.enable_encoder()
        
    def enable_encoder(self):
        if self.seq_type == 'nn':
            self.encoder = OneHotEncoder(sparse=False)
            self.encoder.drop_idx_ = None
            self.encoder.categories_ = [np.array(['A', 'C', 'G', 'T'], dtype='<U1')]*self.seq_len

    def discretize_seq(self,data):
        """
        discretize sequence into character
        argument:
        ...data: can be dataframe with UTR columns , or can be single string
        """
        if type(data) is pd.DataFrame:
            return np.stack(data.UTR.apply(lambda x: list(x)))
        elif type(data) is str:
            return np.array(list(data))
    
    def transform(self,data,flattern=True):
        """
        One hot encode
        argument:
        data : is a 2D array
        flattern : True
        """
        X = self.encoder.transform(data)                             # 400 for each seq
        X_M = np.stack([seq.reshape(self.seq_len,4) for seq in X])   # i.e 100*4
        return X if flattern else X_M
    
    def d_transform(self,data,flattern=True):
        """
        discretize data and put into transform
        """
        X = self.discretize_seq(data)
        return self.transform(X,flattern)


# =====================|   logger       |=======================

def setup_logs(vae_log_path,level=None):
    """

    :param save_dir:  the directory to set up logs
    :param type:  'model' for saving logs in 'logs/cpc'; 'imp' for saving logs in 'logs/imp'
    :param run_name:
    :return:logger
    """
    # initialize logger
    logger = logging.getLogger("VAE")
    logger.setLevel(logging.INFO)
    if level=='warning':
        logger.setLevel(logging.WARNING)

    # create the logging file handler
    log_file = os.path.join(vae_log_path)
    fh = logging.FileHandler(log_file)

    # create the logging console handler
    ch = logging.StreamHandler()

    # format
    formatter = logging.Formatter("%(asctime)s - %(message)s")
    fh.setFormatter(formatter)

    # add handlers to logger object
    logger.addHandler(fh)
    logger.addHandler(ch)

    return logger

def clean_value_dict(dict):
    """
    deal with verbose dict where the values maybe torch object, extact the item and return clean dict
    """
    clean_dict={}
    for k,v in dict.items():
        
        try:
            v = v.item()
        except:
            v = v
        clean_dict[k] = v
    return clean_dict

def fix_parameter(model,modual_to_fix,fix_or_unfix=False):
    """
    for a given model, fix part of the parameter to fine-tuning / transfering 
    args:
    model : `nn.Modual`,initiated model instance
    modual_to_fix : str, define which part of the model will not update by gradient 
                    e.g. "soft_share" then 
    """
    
    fix_part = eval("model."+modual_to_fix)   # e.g. model.shoft_share
     
    for param in fix_part.parameters():
            param.requires_grad = fix_or_unfix
    
    return model

def unfix_parameter(model,modual_to_fix,fix_or_unfix=False):
    return fix_parameter(model,modual_to_fix,fix_or_unfix=True)

def snapshot(vae_pth_path, state):
    logger = logging.getLogger("VAE")
    # torch.save can save any object
    # dict type object in our cases
    torch.save(state, vae_pth_path)
    logger.info("Snapshot saved to {}\n".format(vae_pth_path))


def load_model(popen,model,logger=None):
    
    info = lambda x: print(x) if logger==None else logger.info(x)
    popen.vae_pth_path = '/mnt/sina/run/ml/gan/dev/git/UTRGAN/src/mrl_optimization/script/checkpoint/RL_hard_share_MTL/3M/small_repective_filed_strides1113-model_best_cv1.pth'
    checkpoint = torch.load(popen.vae_pth_path, map_location=torch.device('cpu')) 
    if isinstance(checkpoint['state_dict'], collections.OrderedDict):
            # optimizer.load_state_dict(checkpoint['optimizer'])
        model.load_state_dict(checkpoint['state_dict'])
    else:
        model = checkpoint['state_dict']
    
    info(' \t \t ==============<<< encoder load from >>>============== \t \t ')
    info(" \t"+popen.vae_pth_path)
    
    return model
    
def get_config_cuda(config_file):
    with open(config_file,'r') as f:
        lines = f.read_lines()
        for line in lines:
            if "cuda_id =" in line:
                device = line.split("=")[1].strip()
                break
    device = int(device) if device.isdigit() else device
    return device

def resume(popen,optimizer,logger):
    """
    for a experiment, check whether it;s a new run, and create dir 
    """
    #run_name = model_stype + time.strftime("__%Y_%m_%d_%H:%M"))
    
    if popen.Resumable:
        
        checkpoint = torch.load(popen.vae_pth_path, map_location=torch.device('cpu'))   # xx-model-best.pth
        previous_epoch = checkpoint['epoch']
        previous_loss = checkpoint['validation_loss']
        previous_acc = checkpoint['validation_acc']
        
        
        # very important
        if (type(optimizer) == ScheduledOptim):
            optimizer.n_current_steps = popen.n_current_steps
            optimizer.delta = popen.delta
        
        logger.info(" \t \t ========================================================= \t \t ")
        logger.info(' \t \t ==============<<< Resume from checkpoint>>>============== \t \t \n')
        logger.info(" \t"+popen.vae_pth_path+'\n')
        logger.info(" \t \t ========================================================= \t \t \n")
        
        return previous_epoch,previous_loss,previous_acc
        
    
egfp_seq = "atgggcgaattaagtaagggcgaggagctgttcaccggggtggtgcccatcctggtcgagctggacggcgacgtaaacggccacaagttcagcgtgtccggcgagggcgagggcgatgccacctacggcaagctgaccctgaagttcatctgcaccaccggcaagctgcccgtgccctggcccaccctcgtgaccaccctgacctacggcgtgcagtgcttcagccgctaccccgaccacatgaagcagcacgacttcttcaagtccgccatgcccgaaggctacgtccaggagcgcaccatcttct"
eGFP_seq = egfp_seq.upper()