# Copyright 2026 Google LLC. # # Licensed under the Apache License, Version 2.0 (the "License"); # you may not use this file except in compliance with the License. # You may obtain a copy of the License at # # http://www.apache.org/licenses/LICENSE-2.0 # # Unless required by applicable law or agreed to in writing, software # distributed under the License is distributed on an "AS IS" BASIS, # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. # See the License for the specific language governing permissions and # limitations under the License. """A one-hot encoder for DNA sequences.""" import numpy as np import numpy.typing as np_typing class DNAOneHotEncoder: """A one-hot encoder for DNA sequences. A -> [1, 0, 0, 0] C -> [0, 1, 0, 0] G -> [0, 0, 1, 0] T -> [0, 0, 0, 1] all other characters are encoded as zeros [0, 0, 0, 0]. """ def __init__(self, dtype: np_typing.DTypeLike = np.float32): self._lookup_table = np.zeros((256, 4), dtype=dtype) self._lookup_table[ord('A')] = [1, 0, 0, 0] self._lookup_table[ord('C')] = [0, 1, 0, 0] self._lookup_table[ord('G')] = [0, 0, 1, 0] self._lookup_table[ord('T')] = [0, 0, 0, 1] self._lookup_table[ord('a')] = self._lookup_table[ord('A')] self._lookup_table[ord('c')] = self._lookup_table[ord('C')] self._lookup_table[ord('g')] = self._lookup_table[ord('G')] self._lookup_table[ord('t')] = self._lookup_table[ord('T')] def encode(self, seq: str) -> np.ndarray: """One-hot encodes a DNA sequence string. Args: seq: The DNA sequence string (e.g., "AGCTNacgt"). Returns: A 2D numpy array of shape (sequence_length, 4) containing the one-hot encoded representation of the sequence. """ byte_values = np.frombuffer(seq.encode('latin1'), dtype=np.uint8) return self._lookup_table[byte_values]