| { | |
| "PTGS2": { | |
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| [ | |
| "CUL3", | |
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| [ | |
| "SEC31A", | |
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| [ | |
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| [ | |
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| [ | |
| "ARIH1", | |
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| [ | |
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| [ | |
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| [ | |
| "BAD", | |
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| [ | |
| "FOXO3", | |
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| [ | |
| "TARDBP", | |
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| [ | |
| "COPS5", | |
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| ], | |
| [ | |
| "ARHGAP24", | |
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| [ | |
| "IL4R", | |
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| [ | |
| "IL2RG", | |
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| [ | |
| "RHOA", | |
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| [ | |
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| [ | |
| "TP53", | |
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| [ | |
| "RAC1", | |
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| [ | |
| "SMARCA4", | |
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| [ | |
| "IKBKB", | |
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| [ | |
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| [ | |
| "IL13RA1", | |
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| [ | |
| "JAK1", | |
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| [ | |
| "JAK3", | |
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| [ | |
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| [ | |
| "WNK1", | |
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| [ | |
| "VAV1", | |
| -0.125 | |
| ] | |
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| "YWHAZ", | |
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| [ | |
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| [ | |
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| [ | |
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| [ | |
| "LAT", | |
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| [ | |
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| [ | |
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| [ | |
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| [ | |
| "TOB1", | |
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| [ | |
| "CFLAR", | |
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| [ | |
| "CTBP1", | |
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| [ | |
| "STAT6", | |
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| [ | |
| "AIMP1", | |
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| "IL1R2", | |
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| [ | |
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| [ | |
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| [ | |
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| [ | |
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| [ | |
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| [ | |
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| [ | |
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| [ | |
| "BID", | |
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| [ | |
| "STAT1", | |
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| [ | |
| "MYC", | |
| -0.25 | |
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| [ | |
| "ATF2", | |
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| [ | |
| "APP", | |
| -0.25 | |
| ], | |
| [ | |
| "HNRNPK", | |
| -0.25 | |
| ] | |
| ], | |
| "n_downstream_genes": 81, | |
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| [ | |
| "PPP2CA", | |
| 0.25 | |
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| [ | |
| "TRAF5", | |
| 0.25 | |
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| [ | |
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| [ | |
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| [ | |
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| [ | |
| "TP53", | |
| 0.125 | |
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| [ | |
| "VHL", | |
| 0.125 | |
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| [ | |
| "ENG", | |
| 0.125 | |
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| [ | |
| "FXN", | |
| 0.125 | |
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| [ | |
| "VCL", | |
| 0.125 | |
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| [ | |
| "MAPRE1", | |
| 0.125 | |
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| [ | |
| "RUNX3", | |
| 0.125 | |
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| [ | |
| "YY1", | |
| 0.125 | |
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| [ | |
| "PTPN2", | |
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| [ | |
| "CFL1", | |
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| "top_downregulated": [ | |
| [ | |
| "PSIP1", | |
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| [ | |
| "TNFRSF1B", | |
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| [ | |
| "AKT1", | |
| -0.5 | |
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| [ | |
| "TNFRSF1A", | |
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| [ | |
| "PIK3CG", | |
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| [ | |
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| [ | |
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| [ | |
| "GCLC", | |
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| [ | |
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| [ | |
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| [ | |
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| [ | |
| "IKBKB", | |
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| [ | |
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| [ | |
| "RAC1", | |
| -0.375 | |
| ], | |
| [ | |
| "SET", | |
| -0.375 | |
| ] | |
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| "n_downstream_genes": 202, | |
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| "IL6": { | |
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| [ | |
| "CDK4", | |
| 0.125 | |
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| [ | |
| "YY1", | |
| 0.125 | |
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| [ | |
| "LCP2", | |
| 0.125 | |
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| [ | |
| "CDKN1B", | |
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| [ | |
| "KLF10", | |
| 0.125 | |
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| [ | |
| "PDP1", | |
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| [ | |
| "PTEN", | |
| 0.125 | |
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| [ | |
| "FOXO3", | |
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| [ | |
| "MAP3K5", | |
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| [ | |
| "PTPN2", | |
| 0.125 | |
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| "top_downregulated": [ | |
| [ | |
| "JAK2", | |
| -0.875 | |
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| [ | |
| "IL6ST", | |
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| [ | |
| "JAK1", | |
| -0.625 | |
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| [ | |
| "IL6R", | |
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| [ | |
| "TYK2", | |
| -0.375 | |
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| [ | |
| "GAB2", | |
| -0.375 | |
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| [ | |
| "STAT3", | |
| -0.375 | |
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| [ | |
| "PTPN11", | |
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| [ | |
| "STAT5A", | |
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| [ | |
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| [ | |
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| [ | |
| "IFNGR1", | |
| -0.25 | |
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| [ | |
| "GRB2", | |
| -0.25 | |
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| [ | |
| "STAT6", | |
| -0.25 | |
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| [ | |
| "IFNGR2", | |
| -0.25 | |
| ] | |
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| "n_downstream_genes": 61, | |
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| "SOCS3": { | |
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| [ | |
| "AKT1", | |
| 1.25 | |
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| [ | |
| "MAPK14", | |
| 1.125 | |
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| [ | |
| "IL6ST", | |
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| [ | |
| "CDKN1A", | |
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| [ | |
| "SIGLEC7", | |
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| [ | |
| "TP53", | |
| 0.75 | |
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| [ | |
| "MAP3K7", | |
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| [ | |
| "MAP2K7", | |
| 0.75 | |
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| [ | |
| "RAC1", | |
| 0.625 | |
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| [ | |
| "RARA", | |
| 0.5 | |
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| [ | |
| "MAPK1", | |
| 0.5 | |
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| [ | |
| "IRF5", | |
| 0.5 | |
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| [ | |
| "MCL1", | |
| 0.5 | |
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| [ | |
| "BID", | |
| 0.5 | |
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| [ | |
| "RELA", | |
| 0.5 | |
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| ], | |
| "top_downregulated": [ | |
| [ | |
| "JAK2", | |
| -1.75 | |
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| [ | |
| "STAT5A", | |
| -1.25 | |
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| [ | |
| "JAK1", | |
| -1.0 | |
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| [ | |
| "STAT1", | |
| -0.75 | |
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| [ | |
| "STAT3", | |
| -0.75 | |
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| [ | |
| "STAT4", | |
| -0.75 | |
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| [ | |
| "GAB2", | |
| -0.625 | |
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| [ | |
| "PTPN11", | |
| -0.625 | |
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| [ | |
| "BTK", | |
| -0.625 | |
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| [ | |
| "TYK2", | |
| -0.625 | |
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| [ | |
| "MYC", | |
| -0.625 | |
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| [ | |
| "IL12RB1", | |
| -0.5 | |
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| [ | |
| "STAT6", | |
| -0.5 | |
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| [ | |
| "CTNNB1", | |
| -0.5 | |
| ], | |
| [ | |
| "GTF2I", | |
| -0.5 | |
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| ], | |
| "n_downstream_genes": 763, | |
| "mean_abs_effect": 0.165956749672346 | |
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| "TGFB1": { | |
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| [ | |
| "CAPN1", | |
| 0.625 | |
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| [ | |
| "MARCKS", | |
| 0.375 | |
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| [ | |
| "VAPA", | |
| 0.375 | |
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| [ | |
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| 0.375 | |
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| [ | |
| "CEBPA", | |
| 0.375 | |
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| [ | |
| "CEBPB", | |
| 0.375 | |
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| [ | |
| "CD36", | |
| 0.25 | |
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| [ | |
| "NRAS", | |
| 0.25 | |
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| [ | |
| "PPP2CA", | |
| 0.25 | |
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| [ | |
| "ABCA1", | |
| 0.25 | |
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| [ | |
| "LRRK1", | |
| 0.25 | |
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| [ | |
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| 0.25 | |
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| [ | |
| "RUNX2", | |
| 0.25 | |
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| [ | |
| "EEF1A1", | |
| 0.25 | |
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| [ | |
| "PTPN2", | |
| 0.25 | |
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| [ | |
| "PIK3R1", | |
| -2.0 | |
| ], | |
| [ | |
| "RAC1", | |
| -1.5 | |
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| [ | |
| "TGFBR1", | |
| -1.25 | |
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| [ | |
| "GRB2", | |
| -1.125 | |
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| [ | |
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| [ | |
| "SYK", | |
| -1.0 | |
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| [ | |
| "DAPK1", | |
| -0.875 | |
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| [ | |
| "CTNNB1", | |
| -0.875 | |
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| [ | |
| "TGFBR2", | |
| -0.875 | |
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| [ | |
| "PIK3CG", | |
| -0.875 | |
| ], | |
| [ | |
| "CDKN1A", | |
| -0.875 | |
| ], | |
| [ | |
| "PPP2R2A", | |
| -0.875 | |
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| [ | |
| "AKT1", | |
| -0.75 | |
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| [ | |
| "INSR", | |
| -0.75 | |
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| [ | |
| "RHOA", | |
| -0.75 | |
| ] | |
| ], | |
| "n_downstream_genes": 533, | |
| "mean_abs_effect": 0.20309568480300189 | |
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| "HIF1A": { | |
| "top_upregulated": [ | |
| [ | |
| "S100A12", | |
| 0.0008134663168389971 | |
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| [ | |
| "S100A8", | |
| 0.0005305317544904874 | |
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| [ | |
| "PPBP", | |
| 0.0005028657796491108 | |
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| [ | |
| "NRGN", | |
| 0.0003803229125426224 | |
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| [ | |
| "MT1H", | |
| 0.00032238103713177417 | |
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| [ | |
| "IDO1", | |
| 0.00016444837297460802 | |
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| [ | |
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| 0.0001275240900207309 | |
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| [ | |
| "MT1G", | |
| 0.0001227169890742035 | |
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| [ | |
| "MT1HL1", | |
| 9.230909985226494e-05 | |
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| [ | |
| "MT1A", | |
| 8.65444566497999e-05 | |
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| [ | |
| "MT1E", | |
| 7.576200801041446e-05 | |
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| [ | |
| "MT1M", | |
| 5.678793555160166e-05 | |
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| [ | |
| "INHBA", | |
| 5.174907556743538e-05 | |
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| [ | |
| "LYPD2", | |
| 1.659507360527506e-05 | |
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| [ | |
| "SERPINB2", | |
| 1.557577640575456e-05 | |
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| ], | |
| "top_downregulated": [ | |
| [ | |
| "HIF1A", | |
| -0.15231378650512128 | |
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| [ | |
| "G0S2", | |
| -0.0899483601733625 | |
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| [ | |
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| -0.08843891599198114 | |
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| [ | |
| "PTGS2", | |
| -0.06775858018188559 | |
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| [ | |
| "HLA-DRB1", | |
| -0.06695744893492933 | |
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| [ | |
| "TMSB4X", | |
| -0.051565268523866295 | |
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| [ | |
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| -0.046627735305617694 | |
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| [ | |
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| -0.04370720851767882 | |
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| [ | |
| "HLA-DPA1", | |
| -0.04309927287770282 | |
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| [ | |
| "CXCL8", | |
| -0.041510155249684176 | |
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| [ | |
| "SRGN", | |
| -0.03785925150785177 | |
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| [ | |
| "HLA-DRA", | |
| -0.03714633648291597 | |
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| [ | |
| "LYZ", | |
| -0.03533002467842362 | |
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| [ | |
| "PLAUR", | |
| -0.033321923706293444 | |
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| [ | |
| "SOD2", | |
| -0.033279197447284886 | |
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| ], | |
| "mean_abs_change": 0.0007538475191108255 | |
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| "IRF5": { | |
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| [ | |
| "S100A8", | |
| 0.006895962237654877 | |
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| [ | |
| "SDS", | |
| 0.0005239871508121099 | |
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| [ | |
| "RASGEF1B", | |
| 0.00020764254474868164 | |
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| [ | |
| "BCL6", | |
| 0.00018783634677199616 | |
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| [ | |
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| 0.00014403313556970076 | |
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| [ | |
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| 0.0001088469455209754 | |
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| [ | |
| "SLC7A8", | |
| 9.047486046896145e-05 | |
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| [ | |
| "ALOX5AP", | |
| 4.92001214528229e-05 | |
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| [ | |
| "TFRC", | |
| 4.881696522487404e-05 | |
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| [ | |
| "PHKG1", | |
| 3.2193447632671586e-05 | |
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| [ | |
| "SOCS3", | |
| 2.9233696066954194e-05 | |
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| [ | |
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| 2.270800460759542e-05 | |
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| [ | |
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| 2.116691988543141e-05 | |
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| [ | |
| "MIR4435-2HG", | |
| 1.9844803099479844e-05 | |
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| [ | |
| "GLYR1", | |
| 1.9713190685242186e-05 | |
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| "top_downregulated": [ | |
| [ | |
| "IRF5", | |
| -0.049034021232352516 | |
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| [ | |
| "SAT1", | |
| -0.04257470526835846 | |
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| [ | |
| "HLA-DPB1", | |
| -0.016567939176193442 | |
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| [ | |
| "HLA-DRB1", | |
| -0.00982815800355405 | |
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| [ | |
| "ISG15", | |
| -0.008719249415564087 | |
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| [ | |
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| -0.008579207224463483 | |
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| [ | |
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| -0.0078918440139776 | |
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| [ | |
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| -0.007360925077294011 | |
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| [ | |
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| -0.0063346473315063845 | |
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| [ | |
| "IFIT3", | |
| -0.005948570201037761 | |
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| [ | |
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| -0.004070137653429122 | |
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| [ | |
| "ACP5", | |
| -0.0028732792457450704 | |
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| [ | |
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| -0.002759290416514405 | |
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| [ | |
| "OTUD4", | |
| -0.002481654304085488 | |
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| [ | |
| "NKG7", | |
| -0.002318524392938188 | |
| ] | |
| ], | |
| "mean_abs_change": 7.050768231451016e-05 | |
| } | |
| } |