index,Instruction,molecule,removed_group
26974,Please remove a benzene_ring from the molecule O=C(Cc1ccc(Cl)cc1)NC[C@](O)(c1ccccc1)C(F)(F)F.,O=C(Cc1ccc(Cl)cc1)NC[C@](O)(c1ccccc1)C(F)(F)F,benzene_ring
75570,Please remove a amide from the molecule O=C(C[NH+]1C[C@H]2CC=CC[C@H]2C1)NOCc1ccccc1.,O=C(C[NH+]1C[C@H]2CC=CC[C@H]2C1)NOCc1ccccc1,amide
102138,Please remove a amide from the molecule COC(=O)c1c(C)[nH]c(C(=O)NC2=NCCS2)c1C.,COC(=O)c1c(C)[nH]c(C(=O)NC2=NCCS2)c1C,amide
218964,Please remove a halo from the molecule C[C@H](Oc1ccc([N+](=O)[O-])cc1F)C(=O)[O-].,C[C@H](Oc1ccc([N+](=O)[O-])cc1F)C(=O)[O-],halo
54266,Remove a amine from the molecule CCCN/C(N)=[NH+]/CC[C@@H](C)SC.,CCCN/C(N)=[NH+]/CC[C@@H](C)SC,amine
226306,Please remove a halo from the molecule Ic1ncn(C2CCCC2)n1.,Ic1ncn(C2CCCC2)n1,halo
116785,Please remove a benzene_ring from the molecule CC[C@H](C)Oc1ccc(NC(=O)/C=C/C(=O)[O-])cc1.,CC[C@H](C)Oc1ccc(NC(=O)/C=C/C(=O)[O-])cc1,benzene_ring
129774,Please remove a benzene_ring from the molecule C[C@H]1COC[C@H](C)N1C(=O)c1cc(F)c(F)cc1Cl.,C[C@H]1COC[C@H](C)N1C(=O)c1cc(F)c(F)cc1Cl,benzene_ring
4647,Remove a halo from the molecule O=C(NCCCc1n[nH]c(=O)[nH]1)[C@H]1C[C@@H]1c1c(F)cccc1F.,O=C(NCCCc1n[nH]c(=O)[nH]1)[C@H]1C[C@@H]1c1c(F)cccc1F,halo
241035,Remove a benzene_ring from the molecule O=C([C@@H](O)c1ccccc1)N1CCN(c2ncc(Cl)cc2Cl)CC1.,O=C([C@@H](O)c1ccccc1)N1CCN(c2ncc(Cl)cc2Cl)CC1,benzene_ring
80945,Remove a benzene_ring from the molecule CO[C@@H](C)C(=O)O[C@H](C)c1ccc(C)c([N+](=O)[O-])c1.,CO[C@@H](C)C(=O)O[C@H](C)c1ccc(C)c([N+](=O)[O-])c1,benzene_ring
113549,Please remove a amide from the molecule COc1cccc(-c2cc(C3(C(=O)NC4CC[NH+](Cc5ccccc5)CC4)CC3)no2)c1.,COc1cccc(-c2cc(C3(C(=O)NC4CC[NH+](Cc5ccccc5)CC4)CC3)no2)c1,amide
205850,Remove a halo from the molecule O=C(C1CCC1)N1C[C@@H]2CC[C@H](C1)N(C(=O)c1cc(Cl)ccc1O)C2.,O=C(C1CCC1)N1C[C@@H]2CC[C@H](C1)N(C(=O)c1cc(Cl)ccc1O)C2,halo
95101,Please remove a amide from the molecule CCOc1ccccc1N1C[C@H](C(=O)NC)CC1=O.,CCOc1ccccc1N1C[C@H](C(=O)NC)CC1=O,amide
239829,Remove a amide from the molecule COCCn1ccc2ccc(NC(=O)c3ncccc3OC(C)C)cc21.,COCCn1ccc2ccc(NC(=O)c3ncccc3OC(C)C)cc21,amide
89230,Modify the molecule O=C(Cn1nc(-c2ccccc2F)ccc1=O)c1ccc(Cl)s1 by removing a halo.,O=C(Cn1nc(-c2ccccc2F)ccc1=O)c1ccc(Cl)s1,halo
111718,Please remove a amide from the molecule CCC(C)(C)NC(=O)c1ccc(NC(=O)C(=O)NCC2CCC2)cc1.,CCC(C)(C)NC(=O)c1ccc(NC(=O)C(=O)NCC2CCC2)cc1,amide
126892,Modify the molecule CCOc1ccc(NC(=O)Cc2csc(NC(=O)C3CC3)n2)cc1 by removing a benzene_ring.,CCOc1ccc(NC(=O)Cc2csc(NC(=O)C3CC3)n2)cc1,benzene_ring
244370,Please remove a benzene_ring from the molecule O=C(NC(=S)Nc1cccc(N2CCCC2)c1)c1ccc(Br)cc1.,O=C(NC(=S)Nc1cccc(N2CCCC2)c1)c1ccc(Br)cc1,benzene_ring
124586,Please remove a nitro from the molecule [NH3+]C[C@@H]1CCC[C@@H]1COCc1cc(Cl)ccc1[N+](=O)[O-].,[NH3+]C[C@@H]1CCC[C@@H]1COCc1cc(Cl)ccc1[N+](=O)[O-],nitro
131953,Modify the molecule COc1cccc([C@@H]2C(C#N)=C(N)N(N(C)C)C3=C2C(=O)C[C@@H](c2ccccc2)C3)c1 by removing a amine.,COc1cccc([C@@H]2C(C#N)=C(N)N(N(C)C)C3=C2C(=O)C[C@@H](c2ccccc2)C3)c1,amine
145253,Please remove a halo from the molecule CCC[C@H](C[NH3+])[C@@H](O)c1cc(Cl)c2c(c1)OCCCO2.,CCC[C@H](C[NH3+])[C@@H](O)c1cc(Cl)c2c(c1)OCCCO2,halo
181034,Remove a hydroxyl from the molecule CC(C)[C@H](O)[C@@H](c1ccccc1O)n1nnc2ccccc21.,CC(C)[C@H](O)[C@@H](c1ccccc1O)n1nnc2ccccc21,hydroxyl
111420,Modify the molecule COc1ccc(NC(=O)[C@@H]2CCC[NH+]2Cc2cc(-c3ccccc3)[nH]n2)cc1 by removing a benzene_ring.,COc1ccc(NC(=O)[C@@H]2CCC[NH+]2Cc2cc(-c3ccccc3)[nH]n2)cc1,benzene_ring
209834,Remove a benzene_ring from the molecule COC(=O)c1cccc(SCCS(=O)(=O)c2ccc(C)cc2)c1.,COC(=O)c1cccc(SCCS(=O)(=O)c2ccc(C)cc2)c1,benzene_ring
248810,Remove a amine from the molecule N/C([S-])=[NH+]/Nc1ccc(Cl)c(Cl)c1.,N/C([S-])=[NH+]/Nc1ccc(Cl)c(Cl)c1,amine
117862,Remove a amide from the molecule C=CCCC[C@H](C)[NH+]1CCN(C(=O)Cc2c(C)noc2C)CC1.,C=CCCC[C@H](C)[NH+]1CCN(C(=O)Cc2c(C)noc2C)CC1,amide
101109,Remove a amide from the molecule COCCNC(=O)NC(=O)CNc1cccc(F)c1C.,COCCNC(=O)NC(=O)CNc1cccc(F)c1C,amide
54679,Please remove a benzene_ring from the molecule Cc1nn(Cc2c(Cl)cccc2Cl)c2sc(C(=O)OCc3ncon3)cc12.,Cc1nn(Cc2c(Cl)cccc2Cl)c2sc(C(=O)OCc3ncon3)cc12,benzene_ring
167518,Modify the molecule O=C([O-])CC1(NC(=O)CC2C[C@@H]3CC[C@H](C2)[NH2+]3)CCC1 by removing a amide.,O=C([O-])CC1(NC(=O)CC2C[C@@H]3CC[C@H](C2)[NH2+]3)CCC1,amide
211139,Please remove a amide from the molecule CC(C)NC(=O)c1cc([C@@H]2CN(C(=O)c3ccncc3)CCO2)nc2ccccc12.,CC(C)NC(=O)c1cc([C@@H]2CN(C(=O)c3ccncc3)CCO2)nc2ccccc12,amide
6656,Modify the molecule O=C(OCc1cc(-c2ccccc2)on1)c1ccc(F)cc1 by removing a benzene_ring.,O=C(OCc1cc(-c2ccccc2)on1)c1ccc(F)cc1,benzene_ring
194868,Modify the molecule CCS(=O)(=O)CCNC(=O)C1(c2cccc(C)c2)CCCC1 by removing a amide.,CCS(=O)(=O)CCNC(=O)C1(c2cccc(C)c2)CCCC1,amide
47089,Modify the molecule C[C@H](Sc1nccn1-c1cccc(F)c1)C(=O)Nc1ccc2c(c1)OCCO2 by removing a halo.,C[C@H](Sc1nccn1-c1cccc(F)c1)C(=O)Nc1ccc2c(c1)OCCO2,halo
112161,Modify the molecule CC(C)N1C(=O)C[C@@H]([NH+]2CC[C@H](C(=O)[O-])[C@@H]2C)C1=O by removing a amide.,CC(C)N1C(=O)C[C@@H]([NH+]2CC[C@H](C(=O)[O-])[C@@H]2C)C1=O,amide
221214,Please remove a amide from the molecule CCc1c(C)sc2nc(S[C@H](C)C(=O)N3CCCC[C@@H]3CC)n(C[C@@H]3CCCO3)c(=O)c12.,CCc1c(C)sc2nc(S[C@H](C)C(=O)N3CCCC[C@@H]3CC)n(C[C@@H]3CCCO3)c(=O)c12,amide
220385,Remove a amide from the molecule CCOc1ccc(NC(=O)c2sc3nc(C)nc(N4CCC(C)CC4)c3c2C)cc1.,CCOc1ccc(NC(=O)c2sc3nc(C)nc(N4CCC(C)CC4)c3c2C)cc1,amide
163069,Remove a benzene_ring from the molecule C[C@@H](CCc1ccc(O)cc1)NC(=O)N1CCc2ccccc21.,C[C@@H](CCc1ccc(O)cc1)NC(=O)N1CCc2ccccc21,benzene_ring
99508,Please remove a amine from the molecule C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)COc1cccc(N)c1)CC2.,C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)COc1cccc(N)c1)CC2,amine
130517,Please remove a amide from the molecule C=CCNC(=S)NNC(=O)c1cnc(-c2cnn(C)c2)s1.,C=CCNC(=S)NNC(=O)c1cnc(-c2cnn(C)c2)s1,amide
152902,Modify the molecule CCC1(CC)CCN(c2cccc(F)c2C(C)=O)C1 by removing a halo.,CCC1(CC)CCN(c2cccc(F)c2C(C)=O)C1,halo
94604,Remove a amide from the molecule Cc1c(NC(=O)/C=C/c2ccccc2Br)c(=O)n(-c2ccccc2)n1C.,Cc1c(NC(=O)/C=C/c2ccccc2Br)c(=O)n(-c2ccccc2)n1C,amide
237759,Remove a benzene_ring from the molecule c1ccc(-n2cnnc2SCC2CCOCC2)cc1.,c1ccc(-n2cnnc2SCC2CCOCC2)cc1,benzene_ring
82724,Please remove a amine from the molecule O=C([O-])c1cccc(-c2cc(NCc3ccccn3)nc3[nH]ccc23)c1.,O=C([O-])c1cccc(-c2cc(NCc3ccccn3)nc3[nH]ccc23)c1,amine
12679,Please remove a benzene_ring from the molecule CCCNC(=O)CNC(=O)Nc1ccccc1SC1CCCC1.,CCCNC(=O)CNC(=O)Nc1ccccc1SC1CCCC1,benzene_ring
50786,Modify the molecule Cc1ccc([C@](C)(O)CNC(=O)C(=O)Nc2ccc(Cl)cc2)o1 by removing a amide.,Cc1ccc([C@](C)(O)CNC(=O)C(=O)Nc2ccc(Cl)cc2)o1,amide
215018,Please remove a hydroxyl from the molecule CCC[NH+]1CCC(NC(=O)N[C@@H](CO)c2cccc(OC)c2)CC1.,CCC[NH+]1CCC(NC(=O)N[C@@H](CO)c2cccc(OC)c2)CC1,hydroxyl
54702,Remove a benzene_ring from the molecule COc1cccc2c1N(S(=O)(=O)c1ccc(C#N)cc1C)CCC2.,COc1cccc2c1N(S(=O)(=O)c1ccc(C#N)cc1C)CCC2,benzene_ring
141911,Please remove a amide from the molecule COc1ccc(-c2csc(NC(=O)CSc3ccc(NC(C)=O)cc3)n2)cc1.,COc1ccc(-c2csc(NC(=O)CSc3ccc(NC(C)=O)cc3)n2)cc1,amide
196777,Modify the molecule Cc1cnc([C@@H](C)NC(=O)N[C@@H]2C[C@H](C)N(c3ccccc3)C2=O)s1 by removing a amide.,Cc1cnc([C@@H](C)NC(=O)N[C@@H]2C[C@H](C)N(c3ccccc3)C2=O)s1,amide
231735,Please remove a hydroxyl from the molecule O=c1c2cnc3ncnn3c2ccn1CCCO.,O=c1c2cnc3ncnn3c2ccn1CCCO,hydroxyl
19214,Please remove a amine from the molecule Cc1cc(C)c(C(N)=O)c(N[C@H]2C=C[C@H](C(=O)[O-])C2)[nH+]1.,Cc1cc(C)c(C(N)=O)c(N[C@H]2C=C[C@H](C(=O)[O-])C2)[nH+]1,amine
190465,Remove a benzene_ring from the molecule C[C@H](Oc1ccccc1)c1nnc(NC(=O)Nc2cccc(Cl)c2)s1.,C[C@H](Oc1ccccc1)c1nnc(NC(=O)Nc2cccc(Cl)c2)s1,benzene_ring
201410,Remove a halo from the molecule CC(C)Oc1ccc(CNC(=O)[C@@H](C)Oc2ccccc2)cc1F.,CC(C)Oc1ccc(CNC(=O)[C@@H](C)Oc2ccccc2)cc1F,halo
162707,Remove a halo from the molecule CN(C(=O)N[C@H](Cc1ccccc1)c1ccccc1F)C1CCS(=O)CC1.,CN(C(=O)N[C@H](Cc1ccccc1)c1ccccc1F)C1CCS(=O)CC1,halo
159092,Remove a amine from the molecule O=C(CN1CCN(C(=O)[C@@]23CNC[C@@H]2C[NH2+]C3)CC1)N1CCCCC1.,O=C(CN1CCN(C(=O)[C@@]23CNC[C@@H]2C[NH2+]C3)CC1)N1CCCCC1,amine
64474,Modify the molecule Cc1cccc(O[C@@H](C)C(=O)Nc2nc3ccc(S(C)(=O)=O)cc3s2)c1 by removing a amide.,Cc1cccc(O[C@@H](C)C(=O)Nc2nc3ccc(S(C)(=O)=O)cc3s2)c1,amide
167246,Please remove a hydroxyl from the molecule Cc1ccsc1[C@H](O)[C@@H]1CCOC2(CCSCC2)C1.,Cc1ccsc1[C@H](O)[C@@H]1CCOC2(CCSCC2)C1,hydroxyl
54313,Please remove a halo from the molecule CSC[C@H](CCO)NC(=O)Nc1cc(Br)cn(C)c1=O.,CSC[C@H](CCO)NC(=O)Nc1cc(Br)cn(C)c1=O,halo
166187,Please remove a benzene_ring from the molecule O=C(COc1ccc(-n2cnnn2)cc1)Nc1cccc(S(=O)(=O)N2CCCC2)c1.,O=C(COc1ccc(-n2cnnn2)cc1)Nc1cccc(S(=O)(=O)N2CCCC2)c1,benzene_ring
150511,Remove a hydroxyl from the molecule COc1ccc([C@@H](C)[C@H](C)N[C@@H](CO)c2cc(F)c(F)c(F)c2)cc1.,COc1ccc([C@@H](C)[C@H](C)N[C@@H](CO)c2cc(F)c(F)c(F)c2)cc1,hydroxyl
40740,Remove a amide from the molecule CCn1cc(NC(=O)C[NH+]2CCC[C@H](Cc3nc4ccccc4[nH]3)C2)c(C)n1.,CCn1cc(NC(=O)C[NH+]2CCC[C@H](Cc3nc4ccccc4[nH]3)C2)c(C)n1,amide
80571,Remove a benzene_ring from the molecule CCOC(=O)[C@H]1C(C)=CC(=O)C[C@H]1c1ccccc1.,CCOC(=O)[C@H]1C(C)=CC(=O)C[C@H]1c1ccccc1,benzene_ring
116681,Modify the molecule CCc1nc(C[NH+]2CCC(CNC(=O)C3CC[NH+](C)CC3)CC2)cs1 by removing a amide.,CCc1nc(C[NH+]2CCC(CNC(=O)C3CC[NH+](C)CC3)CC2)cs1,amide
175679,Remove a halo from the molecule Fc1ccc(-c2cn3c(n2)-c2ccccc2C3)cc1.,Fc1ccc(-c2cn3c(n2)-c2ccccc2C3)cc1,halo
197062,Remove a amide from the molecule O=C(CC[NH+]1CCC(C(F)(F)F)CC1)Nc1ccc(F)cc1.,O=C(CC[NH+]1CCC(C(F)(F)F)CC1)Nc1ccc(F)cc1,amide
178309,Remove a amide from the molecule O=C(NCc1ccc(F)cc1F)C1CCN(c2ncnc3c2oc2ccccc23)CC1.,O=C(NCc1ccc(F)cc1F)C1CCN(c2ncnc3c2oc2ccccc23)CC1,amide
212992,Remove a amide from the molecule COc1ccc2c(c1)CCC1=C2N=N[C@@H]1C(=O)N1CC[NH+](C)CC1.,COc1ccc2c(c1)CCC1=C2N=N[C@@H]1C(=O)N1CC[NH+](C)CC1,amide
160405,Remove a benzene_ring from the molecule O=C(NCCc1nc2ccccc2s1)c1ccc(N2CCOCC2)cc1.,O=C(NCCc1nc2ccccc2s1)c1ccc(N2CCOCC2)cc1,benzene_ring
162186,Remove a amide from the molecule Cc1ccc(-n2nc(C(=O)N3CCCC3)c(=O)n(Cc3ccccc3)c2=O)cc1C.,Cc1ccc(-n2nc(C(=O)N3CCCC3)c(=O)n(Cc3ccccc3)c2=O)cc1C,amide
69710,Please remove a amide from the molecule CCc1c(C)sc(NC(=O)[C@H]2CC(C)=C(C)C[C@H]2C(=O)[O-])c1C(=O)NC1CC1.,CCc1c(C)sc(NC(=O)[C@H]2CC(C)=C(C)C[C@H]2C(=O)[O-])c1C(=O)NC1CC1,amide
177502,Modify the molecule O=C(/C=C/c1ccc(Cl)cc1Cl)Nn1cnnc1 by removing a amide.,O=C(/C=C/c1ccc(Cl)cc1Cl)Nn1cnnc1,amide
14220,Modify the molecule O=C(NCCCCN1CCOCC1)C(=O)Nc1cccc(F)c1 by removing a benzene_ring.,O=C(NCCCCN1CCOCC1)C(=O)Nc1cccc(F)c1,benzene_ring
204754,Remove a benzene_ring from the molecule COc1ccc2c(c1OC)C(=O)O[C@@H]2NNC(=O)c1ccccc1Br.,COc1ccc2c(c1OC)C(=O)O[C@@H]2NNC(=O)c1ccccc1Br,benzene_ring
196044,Remove a halo from the molecule C[C@@H]1CCCC[C@@H]1NC(=O)C[NH+]1CCC[C@H](n2c(=O)oc3ccc(Cl)cc32)C1.,C[C@@H]1CCCC[C@@H]1NC(=O)C[NH+]1CCC[C@H](n2c(=O)oc3ccc(Cl)cc32)C1,halo
8872,Remove a benzene_ring from the molecule COc1cc(C#N)cc(I)c1OCC(=O)[O-].,COc1cc(C#N)cc(I)c1OCC(=O)[O-],benzene_ring
77677,Remove a hydroxyl from the molecule CC(C)c1nc2sc3c(NCCCO)ncnc3c2c2c1CCCC2.,CC(C)c1nc2sc3c(NCCCO)ncnc3c2c2c1CCCC2,hydroxyl
1800,Remove a amide from the molecule Cc1nc(C)c(C(=O)OCC(=O)N[C@H]2CCCc3ccccc32)s1.,Cc1nc(C)c(C(=O)OCC(=O)N[C@H]2CCCc3ccccc32)s1,amide
10928,Please remove a amide from the molecule COc1ccc(NC(=O)[C@@H]2CC(=O)OC2(C)C)cn1.,COc1ccc(NC(=O)[C@@H]2CC(=O)OC2(C)C)cn1,amide
80795,Please remove a halo from the molecule N#C[C@H](NC(=O)[C@H]1CCOc2ccccc21)c1ccc(Cl)c(Cl)c1.,N#C[C@H](NC(=O)[C@H]1CCOc2ccccc21)c1ccc(Cl)c(Cl)c1,halo
183163,Remove a amide from the molecule CCNC(=O)[C@@H]1CCCN(C(=O)N[C@@H](CCCO)c2ccccc2)C1.,CCNC(=O)[C@@H]1CCCN(C(=O)N[C@@H](CCCO)c2ccccc2)C1,amide
145485,Remove a amine from the molecule CC(C)(C)OC(=O)[C@H](N)c1ccnc(C#N)c1.,CC(C)(C)OC(=O)[C@H](N)c1ccnc(C#N)c1,amine
186523,Modify the molecule CCc1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)c(=O)[nH]c3c2)cc1 by removing a amine.,CCc1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)c(=O)[nH]c3c2)cc1,amine
98075,Please remove a amide from the molecule CCCNC(=O)C[C@@H](C[NH3+])N1CC[NH+](C(C)(C)C)CC1.,CCCNC(=O)C[C@@H](C[NH3+])N1CC[NH+](C(C)(C)C)CC1,amide
12410,Modify the molecule COc1cccc(NC(=O)[C@@H](NC(=O)c2ccco2)C(C)C)c1 by removing a amide.,COc1cccc(NC(=O)[C@@H](NC(=O)c2ccco2)C(C)C)c1,amide
136377,Please remove a benzene_ring from the molecule O=C(COC(=O)c1ccccc1Br)NCC(F)(F)F.,O=C(COC(=O)c1ccccc1Br)NCC(F)(F)F,benzene_ring
219376,Remove a benzene_ring from the molecule O=C([O-])CC1(Nc2ccc(C(F)(F)F)cc2)CCC1.,O=C([O-])CC1(Nc2ccc(C(F)(F)F)cc2)CCC1,benzene_ring
91829,Please remove a amide from the molecule COc1ccc2c(c1)=C1CCN3C(=O)CN(Cc4ccco4)C(=O)[C@]3(C)[C@H]1[NH+]=2.,COc1ccc2c(c1)=C1CCN3C(=O)CN(Cc4ccco4)C(=O)[C@]3(C)[C@H]1[NH+]=2,amide
247209,Please remove a hydroxyl from the molecule Cc1ccc(Oc2ccc(NC(=O)N[C@H]3[C@@H](CO)[C@H]4CC[C@@H]3C4)cc2)nn1.,Cc1ccc(Oc2ccc(NC(=O)N[C@H]3[C@@H](CO)[C@H]4CC[C@@H]3C4)cc2)nn1,hydroxyl
74243,Please remove a benzene_ring from the molecule CCOCc1cccc(CNC(=O)c2cccc(NC(N)=O)c2)c1.,CCOCc1cccc(CNC(=O)c2cccc(NC(N)=O)c2)c1,benzene_ring
170586,Remove a halo from the molecule CCOC(=O)[C@H](C)N(C)Cc1c[nH]nc1-c1c(F)cccc1F.,CCOC(=O)[C@H](C)N(C)Cc1c[nH]nc1-c1c(F)cccc1F,halo
67195,Modify the molecule CNS(=O)(=O)c1cc(OC)c(Cl)cc1OC by removing a benzene_ring.,CNS(=O)(=O)c1cc(OC)c(Cl)cc1OC,benzene_ring
5990,Please remove a amide from the molecule Cc1ccccc1C(=O)Nc1ccc(OCC(=O)[O-])c(-c2nc3ccccc3s2)c1.,Cc1ccccc1C(=O)Nc1ccc(OCC(=O)[O-])c(-c2nc3ccccc3s2)c1,amide
200020,Remove a benzene_ring from the molecule CCc1cccc(C)c1NC(=O)N[C@@H](C)C[NH+]1CCCCC1.,CCc1cccc(C)c1NC(=O)N[C@@H](C)C[NH+]1CCCCC1,benzene_ring
153121,Modify the molecule O=S(=O)(CC1CCC1)[N-]c1ccc(OC[C@@H]2CCCO2)cc1 by removing a benzene_ring.,O=S(=O)(CC1CCC1)[N-]c1ccc(OC[C@@H]2CCCO2)cc1,benzene_ring
164821,Remove a halo from the molecule COc1ccc(F)cc1C(=O)N(CCc1cccc(F)c1)C1CC1.,COc1ccc(F)cc1C(=O)N(CCc1cccc(F)c1)C1CC1,halo
221605,Modify the molecule Cc1c(Cl)c(C(=O)N2CCOC[C@@H](O)C2)nn1C by removing a amide.,Cc1c(Cl)c(C(=O)N2CCOC[C@@H](O)C2)nn1C,amide
128109,Please remove a amine from the molecule COc1c(C)cnc(CNS(=O)(=O)N2CCCC[C@H]2C)c1C.,COc1c(C)cnc(CNS(=O)(=O)N2CCCC[C@H]2C)c1C,amine
155047,Please remove a benzene_ring from the molecule CCOc1ccc(N2C(=O)O[C@@H](c3ccccc3)[C@]2(O)c2ccccc2)cc1.,CCOc1ccc(N2C(=O)O[C@@H](c3ccccc3)[C@]2(O)c2ccccc2)cc1,benzene_ring
115677,Modify the molecule C[C@@H](C#N)CNC(=O)Nc1ccn(C)n1 by removing a nitrile.,C[C@@H](C#N)CNC(=O)Nc1ccn(C)n1,nitrile
38125,Remove a amide from the molecule O=C1N[C@@H](/C=C/c2ccco2)N2CCOC[C@H]12.,O=C1N[C@@H](/C=C/c2ccco2)N2CCOC[C@H]12,amide
136367,Remove a benzene_ring from the molecule Cc1ccccc1[C@H](CO)CCCS(C)(=O)=O.,Cc1ccccc1[C@H](CO)CCCS(C)(=O)=O,benzene_ring
175475,Please remove a benzene_ring from the molecule COc1ccc(S(=O)(=O)N(C)C(=O)[C@@H](C)c2cccc(F)c2)cc1.,COc1ccc(S(=O)(=O)N(C)C(=O)[C@@H](C)c2cccc(F)c2)cc1,benzene_ring
199100,Remove a benzene_ring from the molecule Cc1cccc(N2N=C(C(=O)NCc3ccccc3)CCC2=O)c1.,Cc1cccc(N2N=C(C(=O)NCc3ccccc3)CCC2=O)c1,benzene_ring
80551,Please remove a benzene_ring from the molecule COc1cccc([C@]2(C(C)(C)C)CCC[NH2+]2)c1.,COc1cccc([C@]2(C(C)(C)C)CCC[NH2+]2)c1,benzene_ring
1796,Please remove a benzene_ring from the molecule CC[C@H](C)NC(=O)CNC(=O)c1ccc(C)c(C)c1.,CC[C@H](C)NC(=O)CNC(=O)c1ccc(C)c(C)c1,benzene_ring
61981,Please remove a halo from the molecule N#C/C(=C\c1cccc(OC2CCCC2)c1)c1ccc(C(F)(F)F)cn1.,N#C/C(=C\c1cccc(OC2CCCC2)c1)c1ccc(C(F)(F)F)cn1,halo
48780,Modify the molecule C[C@H]1CN(C(=O)C[NH+](C)[C@@H](C)c2cccc(NC(=O)c3ccccc3)c2)CCO1 by removing a benzene_ring.,C[C@H]1CN(C(=O)C[NH+](C)[C@@H](C)c2cccc(NC(=O)c3ccccc3)c2)CCO1,benzene_ring
144854,Please remove a amine from the molecule CC[C@@H]1CCCCN1c1ncccc1C(N)=S.,CC[C@@H]1CCCCN1c1ncccc1C(N)=S,amine
19596,Remove a benzene_ring from the molecule COc1cccc(S(=O)(=O)/N=C([O-])/C(C#N)=C\c2ccco2)c1.,COc1cccc(S(=O)(=O)/N=C([O-])/C(C#N)=C\c2ccco2)c1,benzene_ring
28562,Please remove a amide from the molecule CC1=NN(c2ccc(C(=O)N3CCN(Cc4ccsc4)CC3)cc2)CC1.,CC1=NN(c2ccc(C(=O)N3CCN(Cc4ccsc4)CC3)cc2)CC1,amide
109320,Modify the molecule Cc1cc(C)c(C(=O)N[C@@H]2CCCc3ccccc32)c(=O)[nH]1 by removing a amide.,Cc1cc(C)c(C(=O)N[C@@H]2CCCc3ccccc32)c(=O)[nH]1,amide
108288,Please remove a benzene_ring from the molecule CC[C@H]1C[NH+]2CCCC[C@@H]2CN1c1cccc(Cl)c1C.,CC[C@H]1C[NH+]2CCCC[C@@H]2CN1c1cccc(Cl)c1C,benzene_ring
200821,Remove a benzene_ring from the molecule CC[C@H](NC(=O)NC[C@H](O)C1CCOCC1)c1cc(F)ccc1F.,CC[C@H](NC(=O)NC[C@H](O)C1CCOCC1)c1cc(F)ccc1F,benzene_ring
147964,Modify the molecule CCCN[C@]1(C(=O)OC)CC[C@H](n2cc(Cl)cn2)C1 by removing a halo.,CCCN[C@]1(C(=O)OC)CC[C@H](n2cc(Cl)cn2)C1,halo
223895,Modify the molecule COCC[C@]1(C)CC(=O)NC(=O)[C@@H]1C by removing a amide.,COCC[C@]1(C)CC(=O)NC(=O)[C@@H]1C,amide
3843,Remove a amide from the molecule O=C(Nc1ccc(Cl)cc1)c1coc(NC(=O)c2ccco2)n1.,O=C(Nc1ccc(Cl)cc1)c1coc(NC(=O)c2ccco2)n1,amide
123576,Remove a amide from the molecule COC(=O)CCC(=O)Nc1nc(C(C)C)cs1.,COC(=O)CCC(=O)Nc1nc(C(C)C)cs1,amide
135005,Please remove a benzene_ring from the molecule CCCC(=O)N[C@@H]1CCCN(C(=O)[C@H]2CN(Cc3ccccc3)CCO2)C1.,CCCC(=O)N[C@@H]1CCCN(C(=O)[C@H]2CN(Cc3ccccc3)CCO2)C1,benzene_ring
40171,Remove a amide from the molecule O=C(Nc1cccc(NC(=S)Nc2ccccc2)c1)c1ccco1.,O=C(Nc1cccc(NC(=S)Nc2ccccc2)c1)c1ccco1,amide
77346,Please remove a amide from the molecule COCCC(=O)N1CCC[C@@H](C(=O)Nc2ccc(-c3cccc(OC)c3)cc2)C1.,COCCC(=O)N1CCC[C@@H](C(=O)Nc2ccc(-c3cccc(OC)c3)cc2)C1,amide
111617,Please remove a benzene_ring from the molecule Cc1ccc(NC(=O)NC(=O)[C@H](C)[NH2+]CC2(N3CCOCC3)CCCCC2)c(C)c1.,Cc1ccc(NC(=O)NC(=O)[C@H](C)[NH2+]CC2(N3CCOCC3)CCCCC2)c(C)c1,benzene_ring
60033,Remove a amide from the molecule CCCNC(=O)Cn1c(=O)oc2cc(S(=O)(=O)N3C[C@H](C)C[C@@H](C)C3)ccc21.,CCCNC(=O)Cn1c(=O)oc2cc(S(=O)(=O)N3C[C@H](C)C[C@@H](C)C3)ccc21,amide
167157,Please remove a benzene_ring from the molecule CC[NH2+][C@H](Cc1nc(C)c(C)s1)c1cccc(OCC)c1.,CC[NH2+][C@H](Cc1nc(C)c(C)s1)c1cccc(OCC)c1,benzene_ring
144717,Please remove a amide from the molecule COC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H]1c1cccnc1.,COC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H]1c1cccnc1,amide
233621,Modify the molecule Cc1c[nH+]c(CNCCO)[nH]1 by removing a amine.,Cc1c[nH+]c(CNCCO)[nH]1,amine
169526,Please remove a amide from the molecule O=C1CCCOc2ccc(C(=O)N3CCc4ccccc4C3)cc21.,O=C1CCCOc2ccc(C(=O)N3CCc4ccccc4C3)cc21,amide
91316,Remove a nitrile from the molecule Cn1c(CN2CCNC[C@@H]2C#N)cc(=O)n(C)c1=O.,Cn1c(CN2CCNC[C@@H]2C#N)cc(=O)n(C)c1=O,nitrile
145969,Please remove a benzene_ring from the molecule NC(=O)[C@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1.,NC(=O)[C@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1,benzene_ring
110714,Please remove a amide from the molecule COc1cccc2ccc(C[NH+]3CCc4nnc([C@H](C)NC(=O)C5CC5)n4CC3)nc12.,COc1cccc2ccc(C[NH+]3CCc4nnc([C@H](C)NC(=O)C5CC5)n4CC3)nc12,amide
24036,Please remove a benzene_ring from the molecule COc1ccc([C@H](CNC(=O)Nc2cc(C)ccc2C)[NH+]2CCCC2)cc1.,COc1ccc([C@H](CNC(=O)Nc2cc(C)ccc2C)[NH+]2CCCC2)cc1,benzene_ring
86107,Modify the molecule CCCCN(C)C(=O)N[C@@H](c1ccccn1)c1ccccc1OC by removing a benzene_ring.,CCCCN(C)C(=O)N[C@@H](c1ccccn1)c1ccccc1OC,benzene_ring
163264,Please remove a hydroxyl from the molecule COc1cc(C)c([C@@H](C)[NH2+][C@@H](CO)c2ccc(Cl)cc2)cc1OC.,COc1cc(C)c([C@@H](C)[NH2+][C@@H](CO)c2ccc(Cl)cc2)cc1OC,hydroxyl
187087,Please remove a halo from the molecule Cc1nc(COC(=O)[C@@H](Oc2ccc(F)cc2F)C(C)C)no1.,Cc1nc(COC(=O)[C@@H](Oc2ccc(F)cc2F)C(C)C)no1,halo
213352,Modify the molecule Cc1nc2ccccc2n1-c1ncc(Cl)cc1Cl by removing a halo.,Cc1nc2ccccc2n1-c1ncc(Cl)cc1Cl,halo
165709,Modify the molecule COc1ccc2cc(Br)ccc2c1CC(=O)NNC(=O)c1ccc([N+](=O)[O-])cc1 by removing a benzene_ring.,COc1ccc2cc(Br)ccc2c1CC(=O)NNC(=O)c1ccc([N+](=O)[O-])cc1,benzene_ring
127976,Modify the molecule [NH3+]CCOc1ccc(NC(=O)c2ccccn2)cc1 by removing a amide.,[NH3+]CCOc1ccc(NC(=O)c2ccccn2)cc1,amide
151869,Modify the molecule COc1ccc([C@H](C)N[C@@H](C)C(=O)Nc2ccccc2)c(F)c1 by removing a amine.,COc1ccc([C@H](C)N[C@@H](C)C(=O)Nc2ccccc2)c(F)c1,amine
184041,Please remove a halo from the molecule CC[NH+]1CCN(c2ncnc(Nc3cc(Cl)ccc3Cl)c2[N+](=O)[O-])CC1.,CC[NH+]1CCN(c2ncnc(Nc3cc(Cl)ccc3Cl)c2[N+](=O)[O-])CC1,halo
11269,Modify the molecule COc1ccccc1C[NH2+]CC1(N(C)C)CCOCC1 by removing a benzene_ring.,COc1ccccc1C[NH2+]CC1(N(C)C)CCOCC1,benzene_ring
164891,Please remove a benzene_ring from the molecule C[C@H]([NH2+]Cc1ccc(OC(F)(F)F)cc1)c1ccc(-n2cncn2)cc1.,C[C@H]([NH2+]Cc1ccc(OC(F)(F)F)cc1)c1ccc(-n2cncn2)cc1,benzene_ring
44507,Remove a benzene_ring from the molecule CC1(C)CCN(C(=O)[C@H](c2ccccc2)N2CCSCC2)C1.,CC1(C)CCN(C(=O)[C@H](c2ccccc2)N2CCSCC2)C1,benzene_ring
159151,Please remove a amide from the molecule Cc1cccc2sc(NC(=O)[C@@H]3C[C@@H]3C)nc12.,Cc1cccc2sc(NC(=O)[C@@H]3C[C@@H]3C)nc12,amide
91444,Remove a amide from the molecule C[C@@H](C(=O)OCC(=O)N1CCCCC1)N1C(=O)c2ccccc2C1=O.,C[C@@H](C(=O)OCC(=O)N1CCCCC1)N1C(=O)c2ccccc2C1=O,amide
211205,Remove a hydroxyl from the molecule CSc1ccc(C(=O)[C@@H]2CCC[NH+](Cc3ccc(C#CC(C)(C)O)s3)C2)cc1.,CSc1ccc(C(=O)[C@@H]2CCC[NH+](Cc3ccc(C#CC(C)(C)O)s3)C2)cc1,hydroxyl
42213,Please remove a benzene_ring from the molecule O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccs1.,O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccs1,benzene_ring
164760,Please remove a halo from the molecule COc1cc([C@H](O)c2cc(F)c(F)c(F)c2)ccc1Cl.,COc1cc([C@H](O)c2cc(F)c(F)c(F)c2)ccc1Cl,halo
98529,Please remove a benzene_ring from the molecule CC[C@H](CSC)N(C)C(=O)NCc1ccc(OC)c(Cl)c1.,CC[C@H](CSC)N(C)C(=O)NCc1ccc(OC)c(Cl)c1,benzene_ring
201989,Remove a amide from the molecule CCn1cc(C(=O)C(=O)NC2CC(C)(C)[NH2+]C(C)(C)C2)cn1.,CCn1cc(C(=O)C(=O)NC2CC(C)(C)[NH2+]C(C)(C)C2)cn1,amide
8226,Modify the molecule O=C1C[C@H](C(=O)NCCC2=CCCCC2)Cc2nc(NC(=O)c3c(F)cccc3Cl)sc21 by removing a benzene_ring.,O=C1C[C@H](C(=O)NCCC2=CCCCC2)Cc2nc(NC(=O)c3c(F)cccc3Cl)sc21,benzene_ring
192529,Remove a amide from the molecule CCc1cc(N2CCC(NC(=O)C3C[C@@H](C)O[C@H](C)C3)CC2)ncn1.,CCc1cc(N2CCC(NC(=O)C3C[C@@H](C)O[C@H](C)C3)CC2)ncn1,amide
227697,Remove a benzene_ring from the molecule NC(=O)C[C@H](C(=O)[O-])N1C(=O)/C(=C/c2ccccc2)SC1=S.,NC(=O)C[C@H](C(=O)[O-])N1C(=O)/C(=C/c2ccccc2)SC1=S,benzene_ring
179613,Remove a amide from the molecule Cc1cccnc1C[NH+]1CCC[C@H](C(=O)N(C)C)C1.,Cc1cccnc1C[NH+]1CCC[C@H](C(=O)N(C)C)C1,amide
150430,Modify the molecule CC[NH2+][C@H]1CC[C@@H](SC[C@@H](C)CO)C1 by removing a hydroxyl.,CC[NH2+][C@H]1CC[C@@H](SC[C@@H](C)CO)C1,hydroxyl
158,Modify the molecule COc1ccc([C@@H]([NH2+]Cc2ccc(Cl)nc2)c2ccc(F)cc2)cc1 by removing a halo.,COc1ccc([C@@H]([NH2+]Cc2ccc(Cl)nc2)c2ccc(F)cc2)cc1,halo
134912,Remove a amide from the molecule C[C@H]1C[C@H]1C(=O)N1CCN(Cc2csc(CC(=O)N(C)C)n2)CC1.,C[C@H]1C[C@H]1C(=O)N1CCN(Cc2csc(CC(=O)N(C)C)n2)CC1,amide
163661,Please remove a amide from the molecule Cc1ccc([C@H](C)NC(=O)CC2(C(=O)[O-])CCCC2)o1.,Cc1ccc([C@H](C)NC(=O)CC2(C(=O)[O-])CCCC2)o1,amide
175871,Modify the molecule Cc1ccc(NC(=O)C2CCC(N3C(=O)[C@H]4[C@H]5CC[C@H](C5)[C@H]4C3=O)CC2)cc1 by removing a amide.,Cc1ccc(NC(=O)C2CCC(N3C(=O)[C@H]4[C@H]5CC[C@H](C5)[C@H]4C3=O)CC2)cc1,amide
31076,Remove a benzene_ring from the molecule CCOCc1ccccc1NC(=O)c1ccc(-c2cscn2)cc1.,CCOCc1ccccc1NC(=O)c1ccc(-c2cscn2)cc1,benzene_ring
140319,Modify the molecule C[C@@H](CCc1ccco1)[NH2+]C[C@](C)(O)c1ccc(F)cc1F by removing a halo.,C[C@@H](CCc1ccco1)[NH2+]C[C@](C)(O)c1ccc(F)cc1F,halo
81274,Modify the molecule N#Cc1ccc(Cc2cnc(N)s2)cc1 by removing a amine.,N#Cc1ccc(Cc2cnc(N)s2)cc1,amine
36847,Please remove a amine from the molecule O=[N+]([O-])c1ccc(F)c2c1[C@H]1C=CC[C@H]1[C@H](c1cccnc1)N2.,O=[N+]([O-])c1ccc(F)c2c1[C@H]1C=CC[C@H]1[C@H](c1cccnc1)N2,amine
223814,Remove a amide from the molecule CCN(C(=O)[C@@H]1CC(=O)N(c2ccccc2Cl)C1)[C@H](C)c1cccc(OC)c1.,CCN(C(=O)[C@@H]1CC(=O)N(c2ccccc2Cl)C1)[C@H](C)c1cccc(OC)c1,amide
191188,Please remove a benzene_ring from the molecule C[C@H](NC(=O)[C@@H]1CCC[NH+](C)C1)c1ccc(NC(=O)NC2CC2)cc1.,C[C@H](NC(=O)[C@@H]1CCC[NH+](C)C1)c1ccc(NC(=O)NC2CC2)cc1,benzene_ring
1487,Remove a halo from the molecule CSc1ccc2c(C)cc(N3CCO[C@@H](C(F)(F)F)C3)nc2c1.,CSc1ccc2c(C)cc(N3CCO[C@@H](C(F)(F)F)C3)nc2c1,halo
101368,Please remove a amide from the molecule CO[C@@H](CNC(=O)Nc1ccc(N(C)C(C)=O)cc1)c1ccc(F)cc1.,CO[C@@H](CNC(=O)Nc1ccc(N(C)C(C)=O)cc1)c1ccc(F)cc1,amide
24927,Please remove a amide from the molecule C[C@H](CNC(=O)c1ccn(-c2ccccc2F)n1)c1ccsc1.,C[C@H](CNC(=O)c1ccn(-c2ccccc2F)n1)c1ccsc1,amide
185091,Modify the molecule CN(C)S(=O)(=O)c1ccc(NC(=O)CSc2nnc(-c3ccc(F)cc3)o2)cc1 by removing a benzene_ring.,CN(C)S(=O)(=O)c1ccc(NC(=O)CSc2nnc(-c3ccc(F)cc3)o2)cc1,benzene_ring
232673,Please remove a amine from the molecule CN(C(=O)[O-])c1ccc2c(c1)CCN2.,CN(C(=O)[O-])c1ccc2c(c1)CCN2,amine
134392,Remove a amide from the molecule C[C@@H]1CC([NH+]2CCN(CC(=O)N3CCCCC3)CC2)C[C@@H](C)C1.,C[C@@H]1CC([NH+]2CCN(CC(=O)N3CCCCC3)CC2)C[C@@H](C)C1,amide
53275,Remove a amide from the molecule CN(C)C(=O)CN(C)C(=O)c1cc2ccccc2[nH]1.,CN(C)C(=O)CN(C)C(=O)c1cc2ccccc2[nH]1,amide
39033,Remove a nitrile from the molecule CC(=O)[C@@H]1[C@@H](c2ccc(F)cc2F)C(C#N)(C#N)[C@H]2c3ccccc3C=CN12.,CC(=O)[C@@H]1[C@@H](c2ccc(F)cc2F)C(C#N)(C#N)[C@H]2c3ccccc3C=CN12,nitrile
90225,Remove a benzene_ring from the molecule C[C@@H]1CCN(C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)C[C@H](C)C1.,C[C@@H]1CCN(C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)C[C@H](C)C1,benzene_ring
112651,Remove a amide from the molecule CCc1nn(C)c(OC)c1CNC(=O)CCN1c2ccccc2CC[C@@H]1C.,CCc1nn(C)c(OC)c1CNC(=O)CCN1c2ccccc2CC[C@@H]1C,amide
138912,Please remove a amine from the molecule CC(C)Nc1cc2ccccc2cc1C(=O)[O-].,CC(C)Nc1cc2ccccc2cc1C(=O)[O-],amine
88403,Please remove a halo from the molecule CC(C)(C)OC(=O)N1CCC[C@@H](CCOCc2ccc(Cl)nn2)C1.,CC(C)(C)OC(=O)N1CCC[C@@H](CCOCc2ccc(Cl)nn2)C1,halo
246686,Remove a amine from the molecule C[C@@]12CCCC[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)/C(=N/N)CC[C@H]12.,C[C@@]12CCCC[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)/C(=N/N)CC[C@H]12,amine
94134,Modify the molecule Cc1csc(C[S@@](=O)c2ccccc2F)n1 by removing a benzene_ring.,Cc1csc(C[S@@](=O)c2ccccc2F)n1,benzene_ring
38010,Remove a halo from the molecule O=C([O-])c1nn(-c2ccc(Br)cc2)c(=O)c2ccccc12.,O=C([O-])c1nn(-c2ccc(Br)cc2)c(=O)c2ccccc12,halo
227342,Remove a benzene_ring from the molecule CCCOc1ccccc1NC(=O)C(=O)NC[C@@H]1CCC[C@@H]1O.,CCCOc1ccccc1NC(=O)C(=O)NC[C@@H]1CCC[C@@H]1O,benzene_ring
201716,Please remove a amide from the molecule CCCc1[nH]nc(C(=O)Nc2cnc(-c3ccccc3)s2)c1[N+](=O)[O-].,CCCc1[nH]nc(C(=O)Nc2cnc(-c3ccccc3)s2)c1[N+](=O)[O-],amide
178188,Remove a amide from the molecule O=C1C[C@H](N2CCN(c3ccc(O)cc3)CC2)C(=O)N1c1cccc(Cl)c1.,O=C1C[C@H](N2CCN(c3ccc(O)cc3)CC2)C(=O)N1c1cccc(Cl)c1,amide
96056,Modify the molecule CC(C)CNC(=O)c1c(N)n(/N=C/c2ccc(F)cc2)c2nc3ccccc3nc12 by removing a halo.,CC(C)CNC(=O)c1c(N)n(/N=C/c2ccc(F)cc2)c2nc3ccccc3nc12,halo
217036,Please remove a benzene_ring from the molecule NC(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)CCN1S(=O)(=O)c1ccccc1.,NC(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)CCN1S(=O)(=O)c1ccccc1,benzene_ring
96293,Modify the molecule CCc1nc2ncc3c(n2n1)C[C@@H](c1ccccc1C)CC3=O by removing a benzene_ring.,CCc1nc2ncc3c(n2n1)C[C@@H](c1ccccc1C)CC3=O,benzene_ring
240132,Please remove a benzene_ring from the molecule CCc1ccc(C(=O)Cc2ccc([N+](=O)[O-])cc2)o1.,CCc1ccc(C(=O)Cc2ccc([N+](=O)[O-])cc2)o1,benzene_ring
145284,Please remove a amide from the molecule COc1cccc([C@@H]2CCC[NH+]2CCCN2C(=O)NC(C)(C)C2=O)c1.,COc1cccc([C@@H]2CCC[NH+]2CCCN2C(=O)NC(C)(C)C2=O)c1,amide
63031,Modify the molecule CC(C)(CNC(=O)CCC(F)(F)F)c1ccccc1F by removing a halo.,CC(C)(CNC(=O)CCC(F)(F)F)c1ccccc1F,halo
75232,Remove a amide from the molecule CSc1cccc2sc(N3CCN(C(=O)C(C)C)CC3)nc12.,CSc1cccc2sc(N3CCN(C(=O)C(C)C)CC3)nc12,amide
94343,Remove a hydroxyl from the molecule C[C@H](O)[C@@H](C)N1CC[NH2+]CC1(C)C.,C[C@H](O)[C@@H](C)N1CC[NH2+]CC1(C)C,hydroxyl
117110,Remove a halo from the molecule C=C(Cl)CN(C(=O)Cc1c(C)noc1C)[C@H]1CCc2ccccc21.,C=C(Cl)CN(C(=O)Cc1c(C)noc1C)[C@H]1CCc2ccccc21,halo
180180,Please remove a benzene_ring from the molecule CC(=O)c1ccc(S(=O)(=O)N(C)CC(=O)N[C@H]2C[C@@H]2C)cc1.,CC(=O)c1ccc(S(=O)(=O)N(C)CC(=O)N[C@H]2C[C@@H]2C)cc1,benzene_ring
111311,Remove a benzene_ring from the molecule COc1ccc(Nc2nnc(SCC(=O)c3ccc[nH]3)s2)cc1.,COc1ccc(Nc2nnc(SCC(=O)c3ccc[nH]3)s2)cc1,benzene_ring
232608,Remove a benzene_ring from the molecule CCC(=O)N1CCC[C@H]1c1nc2ccccc2n1CCOc1ccc(Cl)c(C)c1.,CCC(=O)N1CCC[C@H]1c1nc2ccccc2n1CCOc1ccc(Cl)c(C)c1,benzene_ring
115125,Modify the molecule CCN(Cc1ccccc1)C(=O)c1ccccc1NC(=O)c1ccccc1 by removing a benzene_ring.,CCN(Cc1ccccc1)C(=O)c1ccccc1NC(=O)c1ccccc1,benzene_ring
116916,Remove a halo from the molecule C[C@H](CNCc1cccc(F)c1)c1ccsc1.,C[C@H](CNCc1cccc(F)c1)c1ccsc1,halo
82301,Modify the molecule CCOC(=O)c1c(NC(=O)c2ccc(C)cc2)sc2c1CC[NH+](C(C)C)C2 by removing a benzene_ring.,CCOC(=O)c1c(NC(=O)c2ccc(C)cc2)sc2c1CC[NH+](C(C)C)C2,benzene_ring
12666,Please remove a amide from the molecule Cc1ccc2ncc(C(=O)Nc3nnc(CC(C)C)s3)n2c1.,Cc1ccc2ncc(C(=O)Nc3nnc(CC(C)C)s3)n2c1,amide
140222,Modify the molecule Cc1noc(C)c1[C@H](C)NC(=O)[C@@H](C)C[NH3+] by removing a amide.,Cc1noc(C)c1[C@H](C)NC(=O)[C@@H](C)C[NH3+],amide
203995,Modify the molecule COc1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1 by removing a benzene_ring.,COc1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1,benzene_ring
157830,Remove a amide from the molecule COC[C@@H]1CN(CCC(=O)N2CCC[C@H]2C)CCO1.,COC[C@@H]1CN(CCC(=O)N2CCC[C@H]2C)CCO1,amide
82382,Remove a amine from the molecule CCS(=O)(=O)NCCc1cc2c(C)ccc(C)c2[nH]c1=O.,CCS(=O)(=O)NCCc1cc2c(C)ccc(C)c2[nH]c1=O,amine
93578,Modify the molecule Cc1cc(N2CCC[C@H](C(=O)c3ccc(F)cc3)C2)ncc1[N+](=O)[O-] by removing a benzene_ring.,Cc1cc(N2CCC[C@H](C(=O)c3ccc(F)cc3)C2)ncc1[N+](=O)[O-],benzene_ring
10060,Modify the molecule Cc1nn(-c2ccccc2F)c2ncc3c(c12)C(=O)N(c1ccc(C(C)C)cc1)C3=O by removing a halo.,Cc1nn(-c2ccccc2F)c2ncc3c(c12)C(=O)N(c1ccc(C(C)C)cc1)C3=O,halo
221599,Please remove a benzene_ring from the molecule CC(=O)N1CC[C@@H](c2c(C(=O)Nc3cccc(OC(C)C)c3)sc3ccccc23)C1.,CC(=O)N1CC[C@@H](c2c(C(=O)Nc3cccc(OC(C)C)c3)sc3ccccc23)C1,benzene_ring
44621,Please remove a benzene_ring from the molecule CCOc1cc(C)ccc1NC(=O)c1cccc(NC(=O)c2cccs2)c1.,CCOc1cc(C)ccc1NC(=O)c1cccc(NC(=O)c2cccs2)c1,benzene_ring
47584,Please remove a amine from the molecule CCOc1ccc(S(=O)(=O)NC[C@H](C)C#N)cc1.,CCOc1ccc(S(=O)(=O)NC[C@H](C)C#N)cc1,amine
14007,Remove a benzene_ring from the molecule C[C@H](CC(=O)N[C@H](C)c1nc2ccccc2[nH]1)Cc1cccc(F)c1.,C[C@H](CC(=O)N[C@H](C)c1nc2ccccc2[nH]1)Cc1cccc(F)c1,benzene_ring
178339,Modify the molecule CCc1nc(-c2cc(C)[nH+]c3ccccc23)nc([O-])c1Br by removing a halo.,CCc1nc(-c2cc(C)[nH+]c3ccccc23)nc([O-])c1Br,halo
232970,Remove a halo from the molecule CN(Cc1ccccc1)S(=O)(=O)c1cc(C(=O)Nc2ccc(Br)cc2)ccc1F.,CN(Cc1ccccc1)S(=O)(=O)c1cc(C(=O)Nc2ccc(Br)cc2)ccc1F,halo
220560,Modify the molecule CC[C@@H](C)[C@@]1(O)CSCC(C)(C)C1 by removing a hydroxyl.,CC[C@@H](C)[C@@]1(O)CSCC(C)(C)C1,hydroxyl
51392,Remove a benzene_ring from the molecule CCN(c1ccccc1)c1[nH+]cnc(Nc2nc3ccccc3s2)c1N.,CCN(c1ccccc1)c1[nH+]cnc(Nc2nc3ccccc3s2)c1N,benzene_ring
154647,Modify the molecule CC(C)Oc1ccccc1NC(=O)Cc1csc(-c2ccoc2)n1 by removing a benzene_ring.,CC(C)Oc1ccccc1NC(=O)Cc1csc(-c2ccoc2)n1,benzene_ring
97482,Modify the molecule C[NH+](Cc1ccccc1NC(=O)NC[C@H](O)c1ccco1)C1CCCCC1 by removing a benzene_ring.,C[NH+](Cc1ccccc1NC(=O)NC[C@H](O)c1ccco1)C1CCCCC1,benzene_ring
190597,Please remove a benzene_ring from the molecule COC(=O)[C@@H](c1cccc(Br)c1)N(C)CC1=CCCOC1.,COC(=O)[C@@H](c1cccc(Br)c1)N(C)CC1=CCCOC1,benzene_ring
171299,Modify the molecule C[C@@H](CSC(C)(C)C)[NH2+]C[C@]1(O)CCc2ccccc21 by removing a hydroxyl.,C[C@@H](CSC(C)(C)C)[NH2+]C[C@]1(O)CCc2ccccc21,hydroxyl
201753,Please remove a amide from the molecule O=C(Cn1c(=O)cnc2ccccc21)N[C@H]1C[C@@H]2CCCc3cccc1c32.,O=C(Cn1c(=O)cnc2ccccc21)N[C@H]1C[C@@H]2CCCc3cccc1c32,amide
245517,Please remove a benzene_ring from the molecule CCS(=O)(=O)[N-]c1ccc(C(=O)/C=C/c2ccc(C)c(F)c2)cc1.,CCS(=O)(=O)[N-]c1ccc(C(=O)/C=C/c2ccc(C)c(F)c2)cc1,benzene_ring
89835,Please remove a amide from the molecule Cc1ccc(OC(=O)N2CCN3C(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]3C2)cc1.,Cc1ccc(OC(=O)N2CCN3C(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]3C2)cc1,amide
171158,Modify the molecule CCOc1ccc(C(=O)CC(F)(F)F)c(Br)c1 by removing a halo.,CCOc1ccc(C(=O)CC(F)(F)F)c(Br)c1,halo
224402,Please remove a amine from the molecule COC(=O)c1cc(N)ccc1N1CCCCC1.,COC(=O)c1cc(N)ccc1N1CCCCC1,amine
233105,Modify the molecule COc1cccc(N2CC[NH+]([C@H](C)c3nc(C(C)(C)C)no3)CC2)c1 by removing a benzene_ring.,COc1cccc(N2CC[NH+]([C@H](C)c3nc(C(C)(C)C)no3)CC2)c1,benzene_ring
211193,Remove a amide from the molecule CCCC(=O)Nc1cccc(C(=O)Nc2ccccn2)c1.,CCCC(=O)Nc1cccc(C(=O)Nc2ccccn2)c1,amide
211399,Modify the molecule C[C@H](NC(=O)C(=O)Nc1cc(F)cc(F)c1)C(=O)NCc1ccco1 by removing a halo.,C[C@H](NC(=O)C(=O)Nc1cc(F)cc(F)c1)C(=O)NCc1ccco1,halo
139627,Please remove a benzene_ring from the molecule Cc1nc(C(C)(C)c2ccccc2)sc1C(=O)NCc1ncoc1C.,Cc1nc(C(C)(C)c2ccccc2)sc1C(=O)NCc1ncoc1C,benzene_ring
150825,Please remove a amide from the molecule Cc1ccc(S(=O)(=O)c2ncsc2SCC(=O)NCc2ccc(C)o2)cc1.,Cc1ccc(S(=O)(=O)c2ncsc2SCC(=O)NCc2ccc(C)o2)cc1,amide
53880,Please remove a amide from the molecule Cc1nc(C[NH+]2CCC[C@H](CNC(=O)c3ccccc3)C2)sc1C.,Cc1nc(C[NH+]2CCC[C@H](CNC(=O)c3ccccc3)C2)sc1C,amide
20057,Remove a benzene_ring from the molecule CCn1cnnc1[C@@H]1CCCN(C(=O)Nc2ccc(OC)cc2)C1.,CCn1cnnc1[C@@H]1CCCN(C(=O)Nc2ccc(OC)cc2)C1,benzene_ring
232684,Modify the molecule CS(=O)(=O)c1ccc(C(=O)N2C[C@@H](C(=O)[O-])[C@H](c3ccncc3)C2)cc1 by removing a amide.,CS(=O)(=O)c1ccc(C(=O)N2C[C@@H](C(=O)[O-])[C@H](c3ccncc3)C2)cc1,amide
68106,Modify the molecule CN[C@@](C)(c1ccoc1)C(F)(F)F by removing a halo.,CN[C@@](C)(c1ccoc1)C(F)(F)F,halo
99379,Modify the molecule O=C1NC(=S)NC(=O)C1=CNCCc1ccc(F)cc1 by removing a benzene_ring.,O=C1NC(=S)NC(=O)C1=CNCCc1ccc(F)cc1,benzene_ring
20520,Modify the molecule Cc1nc(NC(=O)CCn2c([S-])nnc2-c2cccs2)sc1C by removing a amide.,Cc1nc(NC(=O)CCn2c([S-])nnc2-c2cccs2)sc1C,amide
221860,Remove a benzene_ring from the molecule O=C(/C=C1/Sc2ccccc2N(Cc2ccccc2F)C1=O)NCc1ccc2c(c1)OCO2.,O=C(/C=C1/Sc2ccccc2N(Cc2ccccc2F)C1=O)NCc1ccc2c(c1)OCO2,benzene_ring
153806,Please remove a halo from the molecule COc1ccccc1OCCCOc1ccc(F)cc1.,COc1ccccc1OCCCOc1ccc(F)cc1,halo
224265,Modify the molecule O=C(Nc1ccc(NC(=O)[C@@H]2CCCO2)cc1)c1cccnc1 by removing a benzene_ring.,O=C(Nc1ccc(NC(=O)[C@@H]2CCCO2)cc1)c1cccnc1,benzene_ring
99991,Please remove a amide from the molecule C[C@H]1C[C@H](Nc2ccc(NC(=O)C[NH+](C)C)cc2)C(=O)O1.,C[C@H]1C[C@H](Nc2ccc(NC(=O)C[NH+](C)C)cc2)C(=O)O1,amide
230837,Remove a amine from the molecule Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)cc1.,Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)cc1,amine
34415,Remove a amide from the molecule O=C(NCc1csc(=O)[nH]1)c1coc(-c2ccccc2)n1.,O=C(NCc1csc(=O)[nH]1)c1coc(-c2ccccc2)n1,amide
123592,Remove a benzene_ring from the molecule Cc1ccc(C(=O)N[C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)cc1.,Cc1ccc(C(=O)N[C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)cc1,benzene_ring
243030,Remove a amine from the molecule CC(N[C@H]1CCCC[C@@H]1C)=C1C(=O)NC(=S)NC1=O.,CC(N[C@H]1CCCC[C@@H]1C)=C1C(=O)NC(=S)NC1=O,amine
79276,Remove a benzene_ring from the molecule CC(C)c1ccc([C@@H](C)[NH2+]Cc2cnn(C)c2)cc1.,CC(C)c1ccc([C@@H](C)[NH2+]Cc2cnn(C)c2)cc1,benzene_ring
21905,Modify the molecule COc1ccc(C(=O)NCc2ccc(-c3nn4cnnc4s3)cc2)cc1OC by removing a amide.,COc1ccc(C(=O)NCc2ccc(-c3nn4cnnc4s3)cc2)cc1OC,amide
71916,Remove a halo from the molecule O=C(Nc1ccc2c(c1)OCCO2)N1CCN(c2ccc(Cl)c(Cl)c2)CC1.,O=C(Nc1ccc2c(c1)OCCO2)N1CCN(c2ccc(Cl)c(Cl)c2)CC1,halo
152848,Remove a benzene_ring from the molecule O=C(NOCc1ccccc1)N1CCC(c2nc3ccccc3s2)CC1.,O=C(NOCc1ccccc1)N1CCC(c2nc3ccccc3s2)CC1,benzene_ring
29264,Please remove a benzene_ring from the molecule Cc1ccc(C(CO)(CO)CCSc2ccccc2)cc1.,Cc1ccc(C(CO)(CO)CCSc2ccccc2)cc1,benzene_ring
183946,Remove a amide from the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)c1cccc(OCCC(C)C)c1.,Cc1ccc([N+](=O)[O-])cc1NC(=O)c1cccc(OCCC(C)C)c1,amide
244301,Remove a amide from the molecule CC(C)[C@H](C(=O)Nc1ccc(C(=O)N(C)C)cc1)c1ccc(Cl)cc1.,CC(C)[C@H](C(=O)Nc1ccc(C(=O)N(C)C)cc1)c1ccc(Cl)cc1,amide
54689,Remove a amide from the molecule CC(C)[C@H](C)CC(=O)N1CCc2cc([N+](=O)[O-])ccc21.,CC(C)[C@H](C)CC(=O)N1CCc2cc([N+](=O)[O-])ccc21,amide
29878,Modify the molecule CN(C[C@@H]1CCOC1)C(=O)Nc1ccc(Cl)c(CS(C)(=O)=O)c1 by removing a halo.,CN(C[C@@H]1CCOC1)C(=O)Nc1ccc(Cl)c(CS(C)(=O)=O)c1,halo
158767,Modify the molecule CCn1c(CCNC(=O)C2(c3ccc(C(C)C)cc3)CCCC2)n[nH]c1=S by removing a benzene_ring.,CCn1c(CCNC(=O)C2(c3ccc(C(C)C)cc3)CCCC2)n[nH]c1=S,benzene_ring
96802,Please remove a amine from the molecule C[C@H](Oc1ccc(Cl)cc1Cl)C(=O)NC(=S)Nc1ccccc1F.,C[C@H](Oc1ccc(Cl)cc1Cl)C(=O)NC(=S)Nc1ccccc1F,amine
31213,Remove a amide from the molecule C[C@@H](SCC1=NC(=O)C2=C3CCCC[C@@H]3SC2=N1)C(=O)NC1CC1.,C[C@@H](SCC1=NC(=O)C2=C3CCCC[C@@H]3SC2=N1)C(=O)NC1CC1,amide
84509,Modify the molecule C=CCOc1ccccc1CN1CCNC(=O)[C@@H]1c1ccccc1 by removing a amide.,C=CCOc1ccccc1CN1CCNC(=O)[C@@H]1c1ccccc1,amide
48716,Modify the molecule O=C([O-])C[C@H]1C(=O)NCCN1C(=O)CC1CCCC1 by removing a amide.,O=C([O-])C[C@H]1C(=O)NCCN1C(=O)CC1CCCC1,amide
222258,Remove a amide from the molecule CCc1cc(C(F)(F)F)c2c(C3CCN(C(=O)c4cn(C)nc4C)CC3)noc2n1.,CCc1cc(C(F)(F)F)c2c(C3CCN(C(=O)c4cn(C)nc4C)CC3)noc2n1,amide
134818,Remove a halo from the molecule Nc1cnc(N(Cc2cccs2)C2CC2)c(Br)c1.,Nc1cnc(N(Cc2cccs2)C2CC2)c(Br)c1,halo
92415,Remove a benzene_ring from the molecule COc1cccc(/N=C(\O)[C@H](C)Sc2nncn2-c2ccccc2)c1.,COc1cccc(/N=C(\O)[C@H](C)Sc2nncn2-c2ccccc2)c1,benzene_ring
215341,Modify the molecule CC1(C)CC(NCCC(N)=O)CC(C)(C)[NH2+]1 by removing a amide.,CC1(C)CC(NCCC(N)=O)CC(C)(C)[NH2+]1,amide
137966,Remove a halo from the molecule C[C@H]1CCCN(C(=O)Nc2ccc(CCC(F)(F)F)cc2)[C@H]1CO.,C[C@H]1CCCN(C(=O)Nc2ccc(CCC(F)(F)F)cc2)[C@H]1CO,halo
215190,Remove a halo from the molecule COc1cccc2sc(N(C[C@H]3CCCO3)C(=O)c3ccc(Cl)cc3)nc12.,COc1cccc2sc(N(C[C@H]3CCCO3)C(=O)c3ccc(Cl)cc3)nc12,halo
190880,Please remove a amide from the molecule CCN(Cc1ccc(OC)c(OC)c1)C(=O)CN1C[C@@H](C)O[C@H](C)C1.,CCN(Cc1ccc(OC)c(OC)c1)C(=O)CN1C[C@@H](C)O[C@H](C)C1,amide
9486,Remove a amide from the molecule Cc1cc(NC(=O)C2CCN(C(=O)N3CCCC3)CC2)no1.,Cc1cc(NC(=O)C2CCN(C(=O)N3CCCC3)CC2)no1,amide
41012,Please remove a amide from the molecule Cc1ccccc1NS(=O)(=O)c1ccc2[nH]cc(C(=O)N[C@@H]3CCCC[C@@H]3C)c(=O)c2c1.,Cc1ccccc1NS(=O)(=O)c1ccc2[nH]cc(C(=O)N[C@@H]3CCCC[C@@H]3C)c(=O)c2c1,amide
43394,Please remove a benzene_ring from the molecule Cc1cc(/C=C2/C(=O)NC(=S)N=C2[O-])c(C)n1-c1cccc(C(=O)[O-])c1.,Cc1cc(/C=C2/C(=O)NC(=S)N=C2[O-])c(C)n1-c1cccc(C(=O)[O-])c1,benzene_ring
138550,Please remove a benzene_ring from the molecule O=C(CCc1ccccc1)[C@@H]1CCCN(C(=O)CN2CCCCCC2=O)C1.,O=C(CCc1ccccc1)[C@@H]1CCCN(C(=O)CN2CCCCCC2=O)C1,benzene_ring
67985,Modify the molecule C=CCSCC(=O)N[C@@H](C)C(=O)OC by removing a amide.,C=CCSCC(=O)N[C@@H](C)C(=O)OC,amide
27276,Modify the molecule OC1CCC([NH2+][C@H]2CCCc3ccc(Br)cc32)CC1 by removing a hydroxyl.,OC1CCC([NH2+][C@H]2CCCc3ccc(Br)cc32)CC1,hydroxyl
89483,Remove a halo from the molecule C[C@]1([C@H]([NH3+])c2ccc(Cl)cc2Cl)CCCO1.,C[C@]1([C@H]([NH3+])c2ccc(Cl)cc2Cl)CCCO1,halo
227843,Remove a benzene_ring from the molecule Cc1ccc(C)c(CSc2ncc(CO)n2Cc2ccccc2)c1.,Cc1ccc(C)c(CSc2ncc(CO)n2Cc2ccccc2)c1,benzene_ring
162863,Modify the molecule NC(=O)c1cccc(CNC(=O)NCC2CCN(c3cc[nH+]cc3)CC2)c1 by removing a amide.,NC(=O)c1cccc(CNC(=O)NCC2CCN(c3cc[nH+]cc3)CC2)c1,amide
240712,Please remove a halo from the molecule CC1(C)C(C[NH2+]Cc2ccc(Br)cn2)C1(C)C.,CC1(C)C(C[NH2+]Cc2ccc(Br)cn2)C1(C)C,halo
96447,Remove a benzene_ring from the molecule Cn1c([O-])c(Sc2ccc([N+](=O)[O-])cc2)c(=O)c2ccccc21.,Cn1c([O-])c(Sc2ccc([N+](=O)[O-])cc2)c(=O)c2ccccc21,benzene_ring
220810,Please remove a benzene_ring from the molecule Cc1ccccc1[C@@H](C)NC(=O)[C@H]1CC(=O)N(CC2CC2)C1.,Cc1ccccc1[C@@H](C)NC(=O)[C@H]1CC(=O)N(CC2CC2)C1,benzene_ring
123657,Please remove a amine from the molecule O=S(=O)(Cc1ccccc1Cl)NCCc1csc(-c2ccc(F)cc2)n1.,O=S(=O)(Cc1ccccc1Cl)NCCc1csc(-c2ccc(F)cc2)n1,amine
194796,Remove a benzene_ring from the molecule COc1ccc(/C=C(/CC(=O)Nc2ccc3c(c2)OCO3)c2nc3ccccc3s2)cc1OC.,COc1ccc(/C=C(/CC(=O)Nc2ccc3c(c2)OCO3)c2nc3ccccc3s2)cc1OC,benzene_ring
74617,Please remove a amide from the molecule CCCc1ccc(-c2nc(NC(=O)c3cccc(S(C)(=O)=O)c3)sc2C)cc1.,CCCc1ccc(-c2nc(NC(=O)c3cccc(S(C)(=O)=O)c3)sc2C)cc1,amide
206997,Please remove a hydroxyl from the molecule CCC1=NN(C(=O)c2ccncc2)[C@](O)(c2ccc(Cl)cc2)C1.,CCC1=NN(C(=O)c2ccncc2)[C@](O)(c2ccc(Cl)cc2)C1,hydroxyl
215074,Please remove a benzene_ring from the molecule C[NH2+][C@H](c1ccc(OC(C)C)cc1)c1ncc[nH]1.,C[NH2+][C@H](c1ccc(OC(C)C)cc1)c1ncc[nH]1,benzene_ring
77717,Remove a amide from the molecule C[C@@H](NC(=O)NCCCC(=O)N(C)C)c1ccc(-c2ccc(F)cc2)cc1.,C[C@@H](NC(=O)NCCCC(=O)N(C)C)c1ccc(-c2ccc(F)cc2)cc1,amide
185226,Remove a halo from the molecule COc1ccc(Br)cc1CNC(=O)CCl.,COc1ccc(Br)cc1CNC(=O)CCl,halo
61811,Modify the molecule CCN(Cc1ccccn1)c1ccc(C=O)o1 by removing a aldehyde.,CCN(Cc1ccccn1)c1ccc(C=O)o1,aldehyde
75178,Remove a nitrile from the molecule CC(C)[C@@H](CO)NC(=O)[C@@H](C#N)Cc1ccccc1.,CC(C)[C@@H](CO)NC(=O)[C@@H](C#N)Cc1ccccc1,nitrile
73799,Please remove a amide from the molecule CCN(CC(=O)N1CCn2cccc2[C@H]1c1ccccc1Cl)C(=O)C1CCC1.,CCN(CC(=O)N1CCn2cccc2[C@H]1c1ccccc1Cl)C(=O)C1CCC1,amide
179620,Modify the molecule CCn1c(C(=O)NCCCc2c(C)noc2C)cc2ccccc21 by removing a amide.,CCn1c(C(=O)NCCCc2c(C)noc2C)cc2ccccc21,amide
175651,Please remove a amide from the molecule CC(C)[C@@H](CO)NC(=O)C(=O)N1C[C@H](C)Oc2ccccc21.,CC(C)[C@@H](CO)NC(=O)C(=O)N1C[C@H](C)Oc2ccccc21,amide
195373,Modify the molecule CCOc1cccc(CNC(=O)c2cccc(C#N)c2)c1 by removing a nitrile.,CCOc1cccc(CNC(=O)c2cccc(C#N)c2)c1,nitrile
104768,Remove a hydroxyl from the molecule COC(=O)Cn1cc(C[NH+]2CC[C@@H]([NH+]3CCOCC3)[C@H](O)C2)c2ccccc21.,COC(=O)Cn1cc(C[NH+]2CC[C@@H]([NH+]3CCOCC3)[C@H](O)C2)c2ccccc21,hydroxyl
3221,Modify the molecule Cc1cc2oc3c(c(=O)c2cc1Cl)[C@H](c1cccnc1)N(CCCN1CCOCC1)C3=O by removing a amide.,Cc1cc2oc3c(c(=O)c2cc1Cl)[C@H](c1cccnc1)N(CCCN1CCOCC1)C3=O,amide
63614,Please remove a nitrile from the molecule C[C@H](C#N)NC(=O)CCn1ccc2ccccc21.,C[C@H](C#N)NC(=O)CCn1ccc2ccccc21,nitrile
166229,Please remove a amide from the molecule CCO[C@H](C)C(=O)NC1CCC([NH+]2CCCCC2)CC1.,CCO[C@H](C)C(=O)NC1CCC([NH+]2CCCCC2)CC1,amide
228539,Modify the molecule COc1ccc([C@@H]2C(C#N)=C(N)O[C@H]3N=NC(C)=C23)c2ccccc12 by removing a nitrile.,COc1ccc([C@@H]2C(C#N)=C(N)O[C@H]3N=NC(C)=C23)c2ccccc12,nitrile
217312,Remove a amine from the molecule COCCn1c(-c2ccc(C(C)C)cc2)c[nH+]c1N.,COCCn1c(-c2ccc(C(C)C)cc2)c[nH+]c1N,amine
157230,Please remove a benzene_ring from the molecule Cc1cc(C)n([C@H](C)C(=O)NCc2ccccc2-c2ccc(Cn3ccnc3)cc2)n1.,Cc1cc(C)n([C@H](C)C(=O)NCc2ccccc2-c2ccc(Cn3ccnc3)cc2)n1,benzene_ring
244724,Please remove a amine from the molecule Nc1cc2[nH]c(=O)[nH]c2cc1S(=O)(=O)[O-].,Nc1cc2[nH]c(=O)[nH]c2cc1S(=O)(=O)[O-],amine
122638,Remove a amine from the molecule Cc1ccc(S(=O)(=O)/N=C(\[O-])Nc2nnc(C3CC3)s2)cc1.,Cc1ccc(S(=O)(=O)/N=C(\[O-])Nc2nnc(C3CC3)s2)cc1,amine
43397,Remove a halo from the molecule Cc1nn(C)c2c1nc(CCCl)n2[C@@H](C)[C@@H]1CCCO1.,Cc1nn(C)c2c1nc(CCCl)n2[C@@H](C)[C@@H]1CCCO1,halo
78415,Please remove a benzene_ring from the molecule O=C(Cc1noc(-c2ccc(-n3ccnn3)cc2)n1)NC1CCCCC1.,O=C(Cc1noc(-c2ccc(-n3ccnn3)cc2)n1)NC1CCCCC1,benzene_ring
90983,Modify the molecule CCNS(=O)(=O)[C@H]1CCN(C(=O)[C@H]2C[C@@H]2c2sccc2C)C1 by removing a amine.,CCNS(=O)(=O)[C@H]1CCN(C(=O)[C@H]2C[C@@H]2c2sccc2C)C1,amine
227520,Remove a amine from the molecule O=C(NCc1ccc(N2CCOCC2)c(F)c1)N1CC[C@H](Nc2ccccc2)C1.,O=C(NCc1ccc(N2CCOCC2)c(F)c1)N1CC[C@H](Nc2ccccc2)C1,amine
169498,Modify the molecule Cc1cccc(OC[C@@H](C)NC(=O)/C=C/C2CC2)c1 by removing a amide.,Cc1cccc(OC[C@@H](C)NC(=O)/C=C/C2CC2)c1,amide
31939,Please remove a benzene_ring from the molecule Cc1ccc(-n2c(=O)c3sccc3n(Cc3cccc(F)c3)c2=O)cc1.,Cc1ccc(-n2c(=O)c3sccc3n(Cc3cccc(F)c3)c2=O)cc1,benzene_ring
152017,Modify the molecule CC(C)c1ccccc1NC(=O)CN1C(=O)N[C@@](C)(c2ccccc2)C1=O by removing a amide.,CC(C)c1ccccc1NC(=O)CN1C(=O)N[C@@](C)(c2ccccc2)C1=O,amide
73347,Remove a benzene_ring from the molecule C[C@@H](NC[C@@H](O)c1cccc(C(F)(F)F)c1)c1cc(F)cc(F)c1.,C[C@@H](NC[C@@H](O)c1cccc(C(F)(F)F)c1)c1cc(F)cc(F)c1,benzene_ring
36435,Modify the molecule CCOC(=O)/C(=C/c1ccc2c(c1)OCO2)NC(=O)c1cccc([N+](=O)[O-])c1 by removing a amide.,CCOC(=O)/C(=C/c1ccc2c(c1)OCO2)NC(=O)c1cccc([N+](=O)[O-])c1,amide
215667,Modify the molecule O=C(NCCN1CCOCC1)c1cccc(I)c1 by removing a benzene_ring.,O=C(NCCN1CCOCC1)c1cccc(I)c1,benzene_ring
230357,Modify the molecule C[C@H]1CC[C@@H](C)CN1C(=O)Nc1cnn(-c2ccccc2S(C)(=O)=O)c1 by removing a benzene_ring.,C[C@H]1CC[C@@H](C)CN1C(=O)Nc1cnn(-c2ccccc2S(C)(=O)=O)c1,benzene_ring
246869,Remove a benzene_ring from the molecule CCc1noc(-c2ccc(C)c(NC(=O)NCc3ncnn3C)c2)n1.,CCc1noc(-c2ccc(C)c(NC(=O)NCc3ncnn3C)c2)n1,benzene_ring
142563,Modify the molecule COc1ccc(OC(=O)c2ccccc2-c2cncnc2)cc1F by removing a benzene_ring.,COc1ccc(OC(=O)c2ccccc2-c2cncnc2)cc1F,benzene_ring
121145,Modify the molecule CN1C(=O)C[C@@H](Nc2ccc(OC(F)F)cn2)[C@@H]1c1ccc(F)cc1 by removing a amide.,CN1C(=O)C[C@@H](Nc2ccc(OC(F)F)cn2)[C@@H]1c1ccc(F)cc1,amide
77881,Modify the molecule C[C@H]1CN(Cc2ccccc2NC(=O)c2ccncc2F)C[C@H](C)O1 by removing a amide.,C[C@H]1CN(Cc2ccccc2NC(=O)c2ccncc2F)C[C@H](C)O1,amide
168321,Modify the molecule CC(C)=CC[NH+]1CCC(CCC(=O)Nc2ccccc2)CC1 by removing a benzene_ring.,CC(C)=CC[NH+]1CCC(CCC(=O)Nc2ccccc2)CC1,benzene_ring
162342,Remove a amide from the molecule CNC(=O)c1c(C)cccc1[N-]S(=O)(=O)c1cc(C)c(F)cc1F.,CNC(=O)c1c(C)cccc1[N-]S(=O)(=O)c1cc(C)c(F)cc1F,amide
77977,Modify the molecule COc1cc(/C=C2/SC(=S)N([C@H]3CCS(=O)(=O)C3)C2=O)ccc1O by removing a amide.,COc1cc(/C=C2/SC(=S)N([C@H]3CCS(=O)(=O)C3)C2=O)ccc1O,amide
119212,Modify the molecule CC(=O)N1CCN(C(=O)[C@H](C)[NH+](C)Cc2nc3ccccc3n2C)CC1 by removing a amide.,CC(=O)N1CCN(C(=O)[C@H](C)[NH+](C)Cc2nc3ccccc3n2C)CC1,amide
15064,Remove a hydroxyl from the molecule COc1ccc(C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2O)cc1OC.,COc1ccc(C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2O)cc1OC,hydroxyl
234051,Please remove a nitrile from the molecule N#Cc1cccc(NC(=O)c2ccc(C[C@H]3CC(=O)NC3=O)cc2)c1.,N#Cc1cccc(NC(=O)c2ccc(C[C@H]3CC(=O)NC3=O)cc2)c1,nitrile
13189,Remove a amide from the molecule C[C@H](NC(=O)C(=O)Nc1ccc(F)cc1F)c1cccc(N2CCCC2=O)c1.,C[C@H](NC(=O)C(=O)Nc1ccc(F)cc1F)c1cccc(N2CCCC2=O)c1,amide
187173,Please remove a amide from the molecule CCc1nnsc1C(=O)N1CC[C@@]2(CCc3ccccc3C(=O)N2)C1.,CCc1nnsc1C(=O)N1CC[C@@]2(CCc3ccccc3C(=O)N2)C1,amide
153234,Please remove a amide from the molecule COc1ncccc1CNC(=O)c1cc(C2CC2)on1.,COc1ncccc1CNC(=O)c1cc(C2CC2)on1,amide
146635,Please remove a amine from the molecule Cc1ccc([C@H](C)NC(=O)c2csc(C#CCN)c2)s1.,Cc1ccc([C@H](C)NC(=O)c2csc(C#CCN)c2)s1,amine
39554,Modify the molecule CC[C@@H](C)N(Cc1c[nH]c2ccccc12)C(=S)Nc1cccc(C)c1 by removing a benzene_ring.,CC[C@@H](C)N(Cc1c[nH]c2ccccc12)C(=S)Nc1cccc(C)c1,benzene_ring
176346,Modify the molecule C[C@H](OCc1ccccc1)C(=O)NCC(=O)Nc1cccc2ccccc12 by removing a amide.,C[C@H](OCc1ccccc1)C(=O)NCC(=O)Nc1cccc2ccccc12,amide
58997,Modify the molecule COc1ccc(N2CCN(C(=O)[C@H](C)NC(=O)c3cc4cc(OC)ccc4n3C)CC2)cc1 by removing a benzene_ring.,COc1ccc(N2CCN(C(=O)[C@H](C)NC(=O)c3cc4cc(OC)ccc4n3C)CC2)cc1,benzene_ring
171159,Modify the molecule COc1ccc(Cc2nnc(SCC(=O)c3ccc(Br)cc3)o2)cc1 by removing a halo.,COc1ccc(Cc2nnc(SCC(=O)c3ccc(Br)cc3)o2)cc1,halo
125440,Modify the molecule Cc1cccc(CN(C)C(=O)[C@@]2(C(F)(F)F)CC[NH2+]C2)n1 by removing a halo.,Cc1cccc(CN(C)C(=O)[C@@]2(C(F)(F)F)CC[NH2+]C2)n1,halo
22164,Modify the molecule CCOC(=O)C1CCN(C(=O)c2oc3ccc(S(=O)(=O)N4C[C@H](C)C[C@@H](C)C4)cc3c2C)CC1 by removing a amide.,CCOC(=O)C1CCN(C(=O)c2oc3ccc(S(=O)(=O)N4C[C@H](C)C[C@@H](C)C4)cc3c2C)CC1,amide
199630,Modify the molecule N#CCSc1cccc(C(=O)N(CC(F)(F)F)c2ccccn2)c1 by removing a benzene_ring.,N#CCSc1cccc(C(=O)N(CC(F)(F)F)c2ccccn2)c1,benzene_ring
141203,Remove a halo from the molecule C[C@@H](Cl)c1nc2cc(Br)cnc2n1C.,C[C@@H](Cl)c1nc2cc(Br)cnc2n1C,halo
84976,Modify the molecule CSCC[C@@H](NC(=O)c1ccc2c(c1)OCO2)C(=O)N1CCC2(CC1)NCCc1[nH+]c[nH]c12 by removing a amide.,CSCC[C@@H](NC(=O)c1ccc2c(c1)OCO2)C(=O)N1CCC2(CC1)NCCc1[nH+]c[nH]c12,amide
75611,Remove a amide from the molecule C[C@H]1CCCCN1C(=O)CNc1ccc(Cl)c([N+](=O)[O-])c1.,C[C@H]1CCCCN1C(=O)CNc1ccc(Cl)c([N+](=O)[O-])c1,amide
209298,Remove a amide from the molecule Cc1c[nH+]ccc1N1CCCN(C(=O)[C@H]2Cc3ccccc3CN2)CC1.,Cc1c[nH+]ccc1N1CCCN(C(=O)[C@H]2Cc3ccccc3CN2)CC1,amide
190485,Please remove a benzene_ring from the molecule C[NH2+][C@@H](Cc1ccc(F)cc1Br)[C@H]1CN(C)CCO1.,C[NH2+][C@@H](Cc1ccc(F)cc1Br)[C@H]1CN(C)CCO1,benzene_ring
195728,Please remove a benzene_ring from the molecule COc1ccc(C)cc1-n1c(SCC2=NC(=O)[C@@H]3SC=CC3=N2)nnc1-c1cccs1.,COc1ccc(C)cc1-n1c(SCC2=NC(=O)[C@@H]3SC=CC3=N2)nnc1-c1cccs1,benzene_ring
72886,Remove a benzene_ring from the molecule COC(CNc1ccc(Br)c([N+](=O)[O-])c1)OC.,COC(CNc1ccc(Br)c([N+](=O)[O-])c1)OC,benzene_ring
92339,Please remove a benzene_ring from the molecule CC(C)C[C@@H](C[C@H](O)c1ccccc1)C(=O)[O-].,CC(C)C[C@@H](C[C@H](O)c1ccccc1)C(=O)[O-],benzene_ring
62393,Modify the molecule O=C(c1cnn(-c2ccccc2)n1)N1CCC(OCc2ccc(F)cc2)CC1 by removing a benzene_ring.,O=C(c1cnn(-c2ccccc2)n1)N1CCC(OCc2ccc(F)cc2)CC1,benzene_ring
77503,Please remove a halo from the molecule COc1ccc(CNC(=O)Cn2c(=O)c3cccn3c3ccc(F)cc32)cc1OC.,COc1ccc(CNC(=O)Cn2c(=O)c3cccn3c3ccc(F)cc32)cc1OC,halo
238856,Modify the molecule C[C@H](Oc1ccccc1)C(=O)N(C)[C@H]1CCC[C@@H]1S(C)(=O)=O by removing a benzene_ring.,C[C@H](Oc1ccccc1)C(=O)N(C)[C@H]1CCC[C@@H]1S(C)(=O)=O,benzene_ring
171059,Modify the molecule C[NH2+][C@H](c1cncc(Br)c1)c1cc(Cl)ccc1OC by removing a halo.,C[NH2+][C@H](c1cncc(Br)c1)c1cc(Cl)ccc1OC,halo
93809,Remove a amide from the molecule NC(=O)CN1CC2(CCC1=O)CC[NH+](Cc1ncccn1)CC2.,NC(=O)CN1CC2(CCC1=O)CC[NH+](Cc1ncccn1)CC2,amide
87967,Please remove a amide from the molecule Cc1n[nH]c(C)c1[C@@H]1CCC[NH+]1CC(=O)N1CCC(C(N)=O)CC1.,Cc1n[nH]c(C)c1[C@@H]1CCC[NH+]1CC(=O)N1CCC(C(N)=O)CC1,amide
210073,Please remove a amide from the molecule C[C@@H](CNC(=O)CS[C@@H]1CCS(=O)(=O)C1)N1C[C@@H](C)O[C@H](C)C1.,C[C@@H](CNC(=O)CS[C@@H]1CCS(=O)(=O)C1)N1C[C@@H](C)O[C@H](C)C1,amide
38619,Modify the molecule C#C[C@@](C)(CC)NC(=O)Cc1ccccc1 by removing a benzene_ring.,C#C[C@@](C)(CC)NC(=O)Cc1ccccc1,benzene_ring
29552,Modify the molecule Cc1nc2sc([C@@H](c3ccc(F)cc3)[NH+]3CCC4(CC3)OCCO4)c([O-])n2n1 by removing a halo.,Cc1nc2sc([C@@H](c3ccc(F)cc3)[NH+]3CCC4(CC3)OCCO4)c([O-])n2n1,halo
196915,Please remove a amide from the molecule CN1C(=O)CSc2ccc(NC(=O)N3CCC([NH+]4CCCCC4)CC3)cc21.,CN1C(=O)CSc2ccc(NC(=O)N3CCC([NH+]4CCCCC4)CC3)cc21,amide
52231,Please remove a amide from the molecule O=C(Cn1c(=O)oc2ccccc21)NCC1CCN(c2nsc3ccccc23)CC1.,O=C(Cn1c(=O)oc2ccccc21)NCC1CCN(c2nsc3ccccc23)CC1,amide
43003,Remove a amide from the molecule CCC1(CC)NC(=O)CN(C[C@]2(C)CCCO2)C1=O.,CCC1(CC)NC(=O)CN(C[C@]2(C)CCCO2)C1=O,amide
143866,Remove a benzene_ring from the molecule CNC(=O)[C@@H]1CCCCN1c1ccc(C#N)c([N+](=O)[O-])c1.,CNC(=O)[C@@H]1CCCCN1c1ccc(C#N)c([N+](=O)[O-])c1,benzene_ring
162612,Modify the molecule O=S1(=O)CC[C@]2(CC[NH2+]C[C@H]2c2ccccc2Br)C1 by removing a benzene_ring.,O=S1(=O)CC[C@]2(CC[NH2+]C[C@H]2c2ccccc2Br)C1,benzene_ring
36645,Remove a halo from the molecule CCn1ncnc1C[NH2+][C@@H](C)CCCCl.,CCn1ncnc1C[NH2+][C@@H](C)CCCCl,halo
110934,Please remove a amide from the molecule COc1ccc(Cl)cc1NC(=O)C(=O)N[C@H](C)C[NH+]1C[C@H](C)C[C@@H](C)C1.,COc1ccc(Cl)cc1NC(=O)C(=O)N[C@H](C)C[NH+]1C[C@H](C)C[C@@H](C)C1,amide
224616,Remove a amide from the molecule C=CCOc1ccccc1C[NH+](C)CC(=O)N1CCC(O)CC1.,C=CCOc1ccccc1C[NH+](C)CC(=O)N1CCC(O)CC1,amide
62163,Please remove a amide from the molecule O=C(c1cn2ccsc2n1)N1CCc2c([nH]c3ccccc23)[C@@H]1c1ccccn1.,O=C(c1cn2ccsc2n1)N1CCc2c([nH]c3ccccc23)[C@@H]1c1ccccn1,amide
171105,Modify the molecule Cc1ccc(NC(=O)Nc2nnc(SCc3ccccc3)s2)cc1 by removing a benzene_ring.,Cc1ccc(NC(=O)Nc2nnc(SCc3ccccc3)s2)cc1,benzene_ring
9738,Modify the molecule O=C(CCc1cccc(F)c1)Nc1n[nH]c2ccc([N+](=O)[O-])cc12 by removing a benzene_ring.,O=C(CCc1cccc(F)c1)Nc1n[nH]c2ccc([N+](=O)[O-])cc12,benzene_ring
58511,Remove a amine from the molecule CC(C)(C)NC(=O)CCNS(=O)(=O)c1ccc(Br)cc1.,CC(C)(C)NC(=O)CCNS(=O)(=O)c1ccc(Br)cc1,amine
237265,Remove a amide from the molecule CC(C)C[C@H](NC(=O)C1CC1)c1cccs1.,CC(C)C[C@H](NC(=O)C1CC1)c1cccs1,amide
69211,Modify the molecule CC1CCN(C(=O)[C@H]2c3ccccc3CC[NH+]2CC(=O)NCc2ccccc2Cl)CC1 by removing a benzene_ring.,CC1CCN(C(=O)[C@H]2c3ccccc3CC[NH+]2CC(=O)NCc2ccccc2Cl)CC1,benzene_ring
177937,Remove a benzene_ring from the molecule CCOc1cc(NC(=O)C(=O)N[C@H](C)[C@H]2CCCO2)ccc1C.,CCOc1cc(NC(=O)C(=O)N[C@H](C)[C@H]2CCCO2)ccc1C,benzene_ring
26896,Remove a nitro from the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)N(C)CC[NH+](C)C1CCN(C)CC1.,Cc1ccc([N+](=O)[O-])cc1NC(=O)N(C)CC[NH+](C)C1CCN(C)CC1,nitro
122348,Modify the molecule CCc1nc(NC(=O)[C@@H](C)NC(=O)c2ccccc2Cl)sc1C by removing a halo.,CCc1nc(NC(=O)[C@@H](C)NC(=O)c2ccccc2Cl)sc1C,halo
137192,Modify the molecule CC(C)[NH+]1CCCN(C(=O)CCNC(=O)c2ccc(F)cc2Cl)CC1 by removing a amide.,CC(C)[NH+]1CCCN(C(=O)CCNC(=O)c2ccc(F)cc2Cl)CC1,amide
5804,Remove a nitrile from the molecule Cc1sc(NC(=O)c2cc(Br)cs2)c(C#N)c1C.,Cc1sc(NC(=O)c2cc(Br)cs2)c(C#N)c1C,nitrile
159339,Modify the molecule O=C([O-])[C@H]1C[C@H](O)CN1C(=O)c1ccccc1O by removing a hydroxyl.,O=C([O-])[C@H]1C[C@H](O)CN1C(=O)c1ccccc1O,hydroxyl
120100,Please remove a benzene_ring from the molecule Cc1cc(C(=O)NCC(C)C)ccc1NC(=O)c1cnn(C(C)C)c1C.,Cc1cc(C(=O)NCC(C)C)ccc1NC(=O)c1cnn(C(C)C)c1C,benzene_ring
71980,Modify the molecule Cc1cccc(C)c1OC1CCN(C(=O)[C@H](C)c2cccs2)CC1 by removing a amide.,Cc1cccc(C)c1OC1CCN(C(=O)[C@H](C)c2cccs2)CC1,amide
247324,Modify the molecule C[C@H]1[C@H](C(=O)[O-])CCN1C(=O)Nc1ccc(F)cc1 by removing a benzene_ring.,C[C@H]1[C@H](C(=O)[O-])CCN1C(=O)Nc1ccc(F)cc1,benzene_ring
204098,Modify the molecule Cc1c(NC(=O)c2cccc3cc[nH]c23)cccc1C(=O)N1CCCC1 by removing a amide.,Cc1c(NC(=O)c2cccc3cc[nH]c23)cccc1C(=O)N1CCCC1,amide
30006,Modify the molecule O=C(Nc1ccccc1I)C1CCN(S(=O)(=O)c2ccccc2F)CC1 by removing a benzene_ring.,O=C(Nc1ccccc1I)C1CCN(S(=O)(=O)c2ccccc2F)CC1,benzene_ring
202346,Please remove a amide from the molecule Cc1cccc(OCC(=O)NC[C@H](c2ccc(C)o2)[NH+]2CCCCC2)c1.,Cc1cccc(OCC(=O)NC[C@H](c2ccc(C)o2)[NH+]2CCCCC2)c1,amide
30122,Please remove a nitro from the molecule O=C(C1CCCC1)N1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])s2)CC1.,O=C(C1CCCC1)N1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])s2)CC1,nitro
109745,Modify the molecule O=C(c1csnn1)N1CCO[C@@H](c2ccc(Cl)cc2)C1 by removing a amide.,O=C(c1csnn1)N1CCO[C@@H](c2ccc(Cl)cc2)C1,amide
211595,Modify the molecule Nc1cc(Cl)c([N+](=O)[O-])cc1COc1ccccc1 by removing a nitro.,Nc1cc(Cl)c([N+](=O)[O-])cc1COc1ccccc1,nitro
10193,Remove a halo from the molecule Cc1cccc(C(=O)NN2Cc3ccccc3C2)c1F.,Cc1cccc(C(=O)NN2Cc3ccccc3C2)c1F,halo
226112,Remove a amine from the molecule COc1ccc(O)c([C@@H](C)Nc2ccc(F)cc2[N+](=O)[O-])c1.,COc1ccc(O)c([C@@H](C)Nc2ccc(F)cc2[N+](=O)[O-])c1,amine
198343,Remove a benzene_ring from the molecule C[C@H](Oc1ccccc1Br)C(=O)N/N=C\c1cc(Cl)ccc1[N+](=O)[O-].,C[C@H](Oc1ccccc1Br)C(=O)N/N=C\c1cc(Cl)ccc1[N+](=O)[O-],benzene_ring
85850,Please remove a amide from the molecule COc1ccnc(NNC(=O)c2cccc(C#N)c2)n1.,COc1ccnc(NNC(=O)c2cccc(C#N)c2)n1,amide
139437,Remove a amide from the molecule CCOC(=O)[C@H](CC)N1CCC(C(=O)N2CCCCCC2)CC1.,CCOC(=O)[C@H](CC)N1CCC(C(=O)N2CCCCCC2)CC1,amide
29121,Modify the molecule COc1cc([C@@H]2Nc3ccccc3C3=[NH+]CCCN32)cc(OC)c1OC by removing a amine.,COc1cc([C@@H]2Nc3ccccc3C3=[NH+]CCCN32)cc(OC)c1OC,amine
168852,Remove a benzene_ring from the molecule CC[C@@H](NC(=O)N1CCN(C(=O)C2CCCCC2)CC1)c1ccc(OC)cc1.,CC[C@@H](NC(=O)N1CCN(C(=O)C2CCCCC2)CC1)c1ccc(OC)cc1,benzene_ring
171130,Remove a amide from the molecule Cc1cccc(C2=CCN(C(=O)NNC(=O)c3ccccc3)CC2)c1.,Cc1cccc(C2=CCN(C(=O)NNC(=O)c3ccccc3)CC2)c1,amide
75682,Modify the molecule CC(=O)C1=C(Nc2ccc(C)cc2)C[C@](C)(O)[C@H](C(C)=O)[C@H]1c1ccc(Cl)cc1 by removing a halo.,CC(=O)C1=C(Nc2ccc(C)cc2)C[C@](C)(O)[C@H](C(C)=O)[C@H]1c1ccc(Cl)cc1,halo
217021,Please remove a benzene_ring from the molecule O=C(NC1CCCCC1)[C@H](c1ccc(F)cc1)N(C(=O)c1cnccn1)c1ccccc1F.,O=C(NC1CCCCC1)[C@H](c1ccc(F)cc1)N(C(=O)c1cnccn1)c1ccccc1F,benzene_ring
5221,Please remove a amine from the molecule C[C@@H](CNCc1ccc(Cl)nc1)[NH+](C)Cc1ccccc1.,C[C@@H](CNCc1ccc(Cl)nc1)[NH+](C)Cc1ccccc1,amine
106216,Remove a amide from the molecule CCCCn1c(SCC(=O)N(C)C2CCCCC2)nc2cc(C)[nH]c2c1=O.,CCCCn1c(SCC(=O)N(C)C2CCCCC2)nc2cc(C)[nH]c2c1=O,amide
20529,Modify the molecule CCc1ccccc1NC(=O)N[C@H](C)C(=O)N1CCCC[C@@H]1C by removing a benzene_ring.,CCc1ccccc1NC(=O)N[C@H](C)C(=O)N1CCCC[C@@H]1C,benzene_ring
76756,Modify the molecule COc1ccc(-n2c(=S)[nH]c3ccc(C)cc32)c(C)c1 by removing a benzene_ring.,COc1ccc(-n2c(=S)[nH]c3ccc(C)cc32)c(C)c1,benzene_ring
142063,Modify the molecule COc1ccc(NC(=O)c2cccc(OC(C)=O)c2)cc1OC by removing a amide.,COc1ccc(NC(=O)c2cccc(OC(C)=O)c2)cc1OC,amide
155984,Modify the molecule Cc1cccc2c(N3CCCN(S(C)(=O)=O)CC3)c(C#N)cnc12 by removing a nitrile.,Cc1cccc2c(N3CCCN(S(C)(=O)=O)CC3)c(C#N)cnc12,nitrile
149549,Modify the molecule Cc1ccc(Cl)cc1NC(=O)C[C@H]1CSc2nc3c(cnn3-c3ccccc3)c(=O)n21 by removing a halo.,Cc1ccc(Cl)cc1NC(=O)C[C@H]1CSc2nc3c(cnn3-c3ccccc3)c(=O)n21,halo
113524,Modify the molecule Cc1ccc(CNC(=O)/C=C/c2cccc(C)c2)cc1 by removing a amide.,Cc1ccc(CNC(=O)/C=C/c2cccc(C)c2)cc1,amide
85190,Please remove a amide from the molecule Cc1cccc(CC(=O)N2CCC3(CCC(=O)N([C@H](C)C(=O)[O-])C3)CC2)c1.,Cc1cccc(CC(=O)N2CCC3(CCC(=O)N([C@H](C)C(=O)[O-])C3)CC2)c1,amide
109900,Remove a benzene_ring from the molecule Cc1ccc(C(C)C)cc1OCC(=O)N(C)[C@@H](C)c1ccc(-n2cncn2)cc1.,Cc1ccc(C(C)C)cc1OCC(=O)N(C)[C@@H](C)c1ccc(-n2cncn2)cc1,benzene_ring
131292,Modify the molecule Brc1cnc(N2CCCC2)cn1 by removing a halo.,Brc1cnc(N2CCCC2)cn1,halo
46376,Remove a amide from the molecule CCSCC[C@H](C)N(C)C(=O)c1cc(=O)c2ccccc2o1.,CCSCC[C@H](C)N(C)C(=O)c1cc(=O)c2ccccc2o1,amide
35558,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)NCc2cscn2)cc1NC(=O)Nc1ccccc1.,Cc1ccc(C(=O)NCc2cscn2)cc1NC(=O)Nc1ccccc1,benzene_ring
158899,Remove a benzene_ring from the molecule O=C(Cn1ncc2c3ccccc3n(Cc3cccc(Cl)c3)c2c1=O)N1CCC2(CC1)OCCO2.,O=C(Cn1ncc2c3ccccc3n(Cc3cccc(Cl)c3)c2c1=O)N1CCC2(CC1)OCCO2,benzene_ring
87843,Modify the molecule COc1cccc([C@H]2[C@H]3[NH+]=c4ccccc4=C3CCN2Cc2cnn(C)c2C)c1 by removing a amine.,COc1cccc([C@H]2[C@H]3[NH+]=c4ccccc4=C3CCN2Cc2cnn(C)c2C)c1,amine
71760,Please remove a nitrile from the molecule CC1(C)CC(=O)C2=C(C1)OC(N)=C(C#N)[C@H]2c1ccc(C(C)(C)C)s1.,CC1(C)CC(=O)C2=C(C1)OC(N)=C(C#N)[C@H]2c1ccc(C(C)(C)C)s1,nitrile
65229,Modify the molecule O=C(Nc1cccc(-c2nnco2)c1)c1cn(-c2ccccc2)nc1-c1cccs1 by removing a benzene_ring.,O=C(Nc1cccc(-c2nnco2)c1)c1cn(-c2ccccc2)nc1-c1cccs1,benzene_ring
94796,Modify the molecule CCOc1ccc(Oc2cncc(C[NH3+])n2)cc1 by removing a benzene_ring.,CCOc1ccc(Oc2cncc(C[NH3+])n2)cc1,benzene_ring
63016,Modify the molecule O=C([O-])c1cnc(Nc2ccccc2)nc1 by removing a benzene_ring.,O=C([O-])c1cnc(Nc2ccccc2)nc1,benzene_ring
137343,Remove a amide from the molecule Cc1ncccc1C(=O)N[C@H](C(N)=S)C(C)C.,Cc1ncccc1C(=O)N[C@H](C(N)=S)C(C)C,amide
128206,Modify the molecule C[C@H]1[NH2+]CC[C@H]1C(=O)N(C)Cc1cc(C#N)ccc1F by removing a amide.,C[C@H]1[NH2+]CC[C@H]1C(=O)N(C)Cc1cc(C#N)ccc1F,amide
209129,Please remove a amide from the molecule CCc1ccc(C(=O)N2CCC[C@@H](c3cc(C(N)=O)[nH]n3)C2)o1.,CCc1ccc(C(=O)N2CCC[C@@H](c3cc(C(N)=O)[nH]n3)C2)o1,amide
198510,Modify the molecule Cc1ccc(N)c(SC[C@@H](C)CO)c1 by removing a amine.,Cc1ccc(N)c(SC[C@@H](C)CO)c1,amine
119998,Please remove a halo from the molecule COc1cc(NC(=O)c2ccccc2C(F)(F)F)cc(OC)c1.,COc1cc(NC(=O)c2ccccc2C(F)(F)F)cc(OC)c1,halo
178854,Please remove a halo from the molecule CO[C@@H](C)C(=O)NNc1ccccc1C(F)(F)F.,CO[C@@H](C)C(=O)NNc1ccccc1C(F)(F)F,halo
211901,Remove a benzene_ring from the molecule CC(=O)Nc1ccc(C(C)=O)cc1OCc1ccc(Br)cc1.,CC(=O)Nc1ccc(C(C)=O)cc1OCc1ccc(Br)cc1,benzene_ring
144533,Modify the molecule Cn1ccnc(NCCSCc2ccc(Cl)cc2Cl)c1=O by removing a amine.,Cn1ccnc(NCCSCc2ccc(Cl)cc2Cl)c1=O,amine
98161,Modify the molecule O=C(Nc1ccc(Nc2ccccc2)cc1)c1ccc(O)nc1 by removing a amine.,O=C(Nc1ccc(Nc2ccccc2)cc1)c1ccc(O)nc1,amine
62030,Please remove a amide from the molecule CCC(=O)Oc1ccc(C(=O)Nc2cc(Cl)ccc2C(=O)[O-])cc1.,CCC(=O)Oc1ccc(C(=O)Nc2cc(Cl)ccc2C(=O)[O-])cc1,amide
130742,Modify the molecule CCN(Cc1ccccn1)C(=O)[C@H]1C[NH2+]C[C@@H]1C by removing a amide.,CCN(Cc1ccccn1)C(=O)[C@H]1C[NH2+]C[C@@H]1C,amide
120102,Please remove a amide from the molecule CC[C@H](C)NC(=O)c1ccc(Cl)c(S(=O)(=O)N2CCN(C)CC2)c1.,CC[C@H](C)NC(=O)c1ccc(Cl)c(S(=O)(=O)N2CCN(C)CC2)c1,amide
141485,Modify the molecule Cc1cccc(OC(=O)CCCN2C(=O)NC3(CCCC3)C2=O)c1 by removing a benzene_ring.,Cc1cccc(OC(=O)CCCN2C(=O)NC3(CCCC3)C2=O)c1,benzene_ring
214155,Please remove a amide from the molecule N#CCc1ccccc1C(=O)OCC(=O)NCc1cccs1.,N#CCc1ccccc1C(=O)OCC(=O)NCc1cccs1,amide
210127,Please remove a benzene_ring from the molecule CCc1cccc(C(=O)N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c1O.,CCc1cccc(C(=O)N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c1O,benzene_ring
143704,Remove a benzene_ring from the molecule C[C@H]1CCCCN1S(=O)(=O)c1ccc(C(=O)N(C)Cc2ccc(F)cc2)cc1.,C[C@H]1CCCCN1S(=O)(=O)c1ccc(C(=O)N(C)Cc2ccc(F)cc2)cc1,benzene_ring
75330,Please remove a halo from the molecule COc1cc(OC)cc(-c2nnc(SCc3ccc(F)cc3)o2)c1.,COc1cc(OC)cc(-c2nnc(SCc3ccc(F)cc3)o2)c1,halo
12008,Please remove a hydroxyl from the molecule Cc1ccccc1C(=O)NCCC(=O)NC[C@H](O)c1ccc(Cl)cc1.,Cc1ccccc1C(=O)NCCC(=O)NC[C@H](O)c1ccc(Cl)cc1,hydroxyl
182920,Remove a amide from the molecule CN(Cc1csc2ccccc12)C(=O)NCc1cccc(C(N)=O)c1.,CN(Cc1csc2ccccc12)C(=O)NCc1cccc(C(N)=O)c1,amide
168029,Remove a halo from the molecule COc1cc(C(=O)Nc2nc3c(C)cccc3s2)cc(Cl)c1OC.,COc1cc(C(=O)Nc2nc3c(C)cccc3s2)cc(Cl)c1OC,halo
132630,Remove a benzene_ring from the molecule C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)NCCCS(=O)(=O)c1ccccc1)CC2.,C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)NCCCS(=O)(=O)c1ccccc1)CC2,benzene_ring
247824,Modify the molecule CCNC(=O)C1CC[NH+]([C@@H](C)c2cccc(C)c2)CC1 by removing a amide.,CCNC(=O)C1CC[NH+]([C@@H](C)c2cccc(C)c2)CC1,amide
176970,Modify the molecule Cn1ncc2c1CCC[C@H]2N[C@H]1C[NH+]2CCC1CC2 by removing a amine.,Cn1ncc2c1CCC[C@H]2N[C@H]1C[NH+]2CCC1CC2,amine
151547,Modify the molecule Cc1cnoc1-c1ccc(C#N)cc1 by removing a nitrile.,Cc1cnoc1-c1ccc(C#N)cc1,nitrile
52539,Remove a hydroxyl from the molecule Cc1c(C[NH2+][C@H]2CCC[C@@H](O)C2)cnn1C.,Cc1c(C[NH2+][C@H]2CCC[C@@H](O)C2)cnn1C,hydroxyl
230914,Please remove a benzene_ring from the molecule Cc1noc(C)c1[C@@H](C)CN[C@H](C)c1ccc(C(C)C)cc1.,Cc1noc(C)c1[C@@H](C)CN[C@H](C)c1ccc(C(C)C)cc1,benzene_ring
58395,Please remove a halo from the molecule CCOC(=O)c1cccc(NC(=O)c2ccccc2F)c1.,CCOC(=O)c1cccc(NC(=O)c2ccccc2F)c1,halo
144220,Remove a amide from the molecule Cc1ccc(OCn2ccc(C(=O)N[C@@H](C)c3cn(C)nc3C)n2)c(C)c1.,Cc1ccc(OCn2ccc(C(=O)N[C@@H](C)c3cn(C)nc3C)n2)c(C)c1,amide
109067,Please remove a amide from the molecule CCCC(=O)N1CCc2[nH]nc(C(=O)NCc3ccc4c(c3)OCO4)c2C1.,CCCC(=O)N1CCc2[nH]nc(C(=O)NCc3ccc4c(c3)OCO4)c2C1,amide
129929,Please remove a benzene_ring from the molecule Cc1ccc(C2=[NH+]CCN2)c(O)c1.,Cc1ccc(C2=[NH+]CCN2)c(O)c1,benzene_ring
45255,Please remove a halo from the molecule CN(C)C(=O)NCC(=O)N1CCc2[nH]nc(-c3ccc(F)c(F)c3)c2C1.,CN(C)C(=O)NCC(=O)N1CCc2[nH]nc(-c3ccc(F)c(F)c3)c2C1,halo
40026,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)CN2C(=O)N[C@@](C)(c3ccccc3Br)C2=O)cc1.,Cc1ccc(C(=O)CN2C(=O)N[C@@](C)(c3ccccc3Br)C2=O)cc1,benzene_ring
240715,Modify the molecule CCCOCC(=O)N[C@H](C)c1cnn(-c2cccc3ccccc23)c1C by removing a amide.,CCCOCC(=O)N[C@H](C)c1cnn(-c2cccc3ccccc23)c1C,amide
8321,Remove a amide from the molecule CC(C)(C)N1C[C@H](NC(=O)NC[C@@](C)(O)c2ccccc2)CC1=O.,CC(C)(C)N1C[C@H](NC(=O)NC[C@@](C)(O)c2ccccc2)CC1=O,amide
89151,Modify the molecule O=C(NC[C@H](O)c1ccco1)c1ccc(SC(F)F)cc1 by removing a halo.,O=C(NC[C@H](O)c1ccco1)c1ccc(SC(F)F)cc1,halo
88437,Please remove a benzene_ring from the molecule CC1=NN(c2ccccc2)C(=O)/C1=C\c1ccc(OCC(=O)[O-])cc1.,CC1=NN(c2ccccc2)C(=O)/C1=C\c1ccc(OCC(=O)[O-])cc1,benzene_ring
59307,Remove a halo from the molecule CCOc1ccccc1N1CC[NH+](Cc2nnsc2Cl)CC1.,CCOc1ccccc1N1CC[NH+](Cc2nnsc2Cl)CC1,halo
141912,Remove a halo from the molecule C[C@@H](CCc1ccco1)[NH2+]Cc1ncccc1F.,C[C@@H](CCc1ccco1)[NH2+]Cc1ncccc1F,halo
82951,Please remove a halo from the molecule NC(=O)CN1CCN(C(=O)C[C@@H](O)c2ccc(Cl)cc2)CC1.,NC(=O)CN1CCN(C(=O)C[C@@H](O)c2ccc(Cl)cc2)CC1,halo
180213,Modify the molecule C[C@@H](NC(=O)Nc1cccc2c1OCCO2)c1ccc(OC(F)F)cc1 by removing a benzene_ring.,C[C@@H](NC(=O)Nc1cccc2c1OCCO2)c1ccc(OC(F)F)cc1,benzene_ring
216873,Modify the molecule COc1ccccc1C(=O)N1CCN(C(=O)Cc2c(C)noc2C)CC1 by removing a benzene_ring.,COc1ccccc1C(=O)N1CCN(C(=O)Cc2c(C)noc2C)CC1,benzene_ring
95366,Remove a amide from the molecule COCCC(=O)N1CCN(S(=O)(=O)c2cnc(-c3ccccn3)nc2C)CC1.,COCCC(=O)N1CCN(S(=O)(=O)c2cnc(-c3ccccn3)nc2C)CC1,amide
6764,Remove a benzene_ring from the molecule CCOc1ccc(O[C@H](C)C(=O)Nc2ccc(C)cc2Br)cc1.,CCOc1ccc(O[C@H](C)C(=O)Nc2ccc(C)cc2Br)cc1,benzene_ring
100925,Modify the molecule COc1ccc(-n2c(C)nc3nc([NH+]4CCCC4)nc([O-])c3c2=S)cc1 by removing a benzene_ring.,COc1ccc(-n2c(C)nc3nc([NH+]4CCCC4)nc([O-])c3c2=S)cc1,benzene_ring
98314,Please remove a hydroxyl from the molecule CCS[C@@H]1CCC[C@](CO)([NH2+]C(C)C)C1.,CCS[C@@H]1CCC[C@](CO)([NH2+]C(C)C)C1,hydroxyl
76499,Please remove a benzene_ring from the molecule COc1ccc2c(c1)CCCN2CC(=O)NCC(=O)Nc1ccc(F)c(F)c1.,COc1ccc2c(c1)CCCN2CC(=O)NCC(=O)Nc1ccc(F)c(F)c1,benzene_ring
220252,Remove a amide from the molecule CC(C)CCN1C[C@@H](C(=O)Nc2ccc3cc[nH]c3c2)CC1=O.,CC(C)CCN1C[C@@H](C(=O)Nc2ccc3cc[nH]c3c2)CC1=O,amide
4828,Remove a nitrile from the molecule CCOc1ccccc1[C@H]1C(C#N)=C(SCC(=O)Nc2cc(C)ccc2C)N=C2CCCC(=O)[C@@H]21.,CCOc1ccccc1[C@H]1C(C#N)=C(SCC(=O)Nc2cc(C)ccc2C)N=C2CCCC(=O)[C@@H]21,nitrile
34195,Modify the molecule CCn1ccnc1SCC(=O)N1CCO[C@@H]2CCCC[C@H]21 by removing a amide.,CCn1ccnc1SCC(=O)N1CCO[C@@H]2CCCC[C@H]21,amide
221792,Modify the molecule N#Cc1c(NC(=O)CCCc2nc(-c3ccccc3)no2)sc2c1CCCC2 by removing a benzene_ring.,N#Cc1c(NC(=O)CCCc2nc(-c3ccccc3)no2)sc2c1CCCC2,benzene_ring
207389,Remove a benzene_ring from the molecule CCc1ccc(NC(=O)N2CCOc3ccccc32)cc1.,CCc1ccc(NC(=O)N2CCOc3ccccc32)cc1,benzene_ring
244295,Modify the molecule O=C(Nc1cc(F)ccc1Cl)[C@@H]1CCCN1C(=O)c1cccs1 by removing a amide.,O=C(Nc1cc(F)ccc1Cl)[C@@H]1CCCN1C(=O)c1cccs1,amide
166534,Remove a halo from the molecule O=C(C[NH2+]CCc1ccccc1)Nc1ccc(Cl)c(Cl)c1.,O=C(C[NH2+]CCc1ccccc1)Nc1ccc(Cl)c(Cl)c1,halo
25242,Modify the molecule O=C(NC(=S)Nc1ccccn1)c1ccc(Cl)cc1 by removing a halo.,O=C(NC(=S)Nc1ccccn1)c1ccc(Cl)cc1,halo
133764,Remove a hydroxyl from the molecule O=C1/C(=C/c2ccc3ccccc3n2)Oc2cc(O)ccc21.,O=C1/C(=C/c2ccc3ccccc3n2)Oc2cc(O)ccc21,hydroxyl
58584,Modify the molecule CC[NH2+]Cc1cnn(-c2cccc(Br)c2)c1C1CC1 by removing a benzene_ring.,CC[NH2+]Cc1cnn(-c2cccc(Br)c2)c1C1CC1,benzene_ring
82880,Remove a hydroxyl from the molecule CC[C@](C)(C[NH3+])[C@H](O)CCc1ccccc1.,CC[C@](C)(C[NH3+])[C@H](O)CCc1ccccc1,hydroxyl
133652,Please remove a amide from the molecule CC(=O)NCCNC(=O)/C=C/c1cc(C(F)(F)F)ccc1Cl.,CC(=O)NCCNC(=O)/C=C/c1cc(C(F)(F)F)ccc1Cl,amide
211492,Please remove a benzene_ring from the molecule C[C@H]1C[C@@H]1C(=O)NC[C@@H](C)Sc1ccc(Br)cc1.,C[C@H]1C[C@@H]1C(=O)NC[C@@H](C)Sc1ccc(Br)cc1,benzene_ring
52436,Remove a benzene_ring from the molecule O=C(Cc1cccc(F)c1F)c1cc(Cl)ccc1F.,O=C(Cc1cccc(F)c1F)c1cc(Cl)ccc1F,benzene_ring
111231,Remove a amide from the molecule CC(=O)N[C@H]1[C@H](OC2=C[C@H]3OC(=O)C=C(C)[C@H]3C=C2)O[C@H](CO)[C@@H](O)[C@@H]1O.,CC(=O)N[C@H]1[C@H](OC2=C[C@H]3OC(=O)C=C(C)[C@H]3C=C2)O[C@H](CO)[C@@H](O)[C@@H]1O,amide
10166,Please remove a amide from the molecule COc1nn(C)cc1C(=O)NCC1CCN(C(=O)c2cccnc2SC)CC1.,COc1nn(C)cc1C(=O)NCC1CCN(C(=O)c2cccnc2SC)CC1,amide
84888,Remove a halo from the molecule Cc1ccc(Cl)cc1NC(=O)CNc1ccc(S(=O)(=O)N2CCCCC2)cc1.,Cc1ccc(Cl)cc1NC(=O)CNc1ccc(S(=O)(=O)N2CCCCC2)cc1,halo
186235,Modify the molecule O=C1NCC=Cc2c1[nH]c(Br)c2Br by removing a halo.,O=C1NCC=Cc2c1[nH]c(Br)c2Br,halo
112751,Remove a benzene_ring from the molecule COc1ccc(F)cc1C(=O)COC(=O)c1csc(-c2ccc(C)cc2)n1.,COc1ccc(F)cc1C(=O)COC(=O)c1csc(-c2ccc(C)cc2)n1,benzene_ring
48767,Remove a amine from the molecule O=C(Nc1cc(Cl)ccc1O)c1cc2n(n1)[C@@H](C(F)(F)F)C[C@H](c1ccc3c(c1)OCO3)N2.,O=C(Nc1cc(Cl)ccc1O)c1cc2n(n1)[C@@H](C(F)(F)F)C[C@H](c1ccc3c(c1)OCO3)N2,amine
218466,Please remove a benzene_ring from the molecule COc1ccc([C@H]2[C@@H]3SC(=O)N=C3S[C@@H](C(=O)[O-])[C@H]2C(=O)c2ccc3c(c2)CCCC3)cc1.,COc1ccc([C@H]2[C@@H]3SC(=O)N=C3S[C@@H](C(=O)[O-])[C@H]2C(=O)c2ccc3c(c2)CCCC3)cc1,benzene_ring
110805,Modify the molecule CCC(=O)Nc1ccc(NC(=O)NCCc2cccs2)cc1C by removing a amide.,CCC(=O)Nc1ccc(NC(=O)NCCc2cccs2)cc1C,amide
233134,Modify the molecule COc1ccc(N2C(=O)/C(=C/c3cn(-c4ccccc4)nc3-c3ccccc3)SC2=S)cc1 by removing a amide.,COc1ccc(N2C(=O)/C(=C/c3cn(-c4ccccc4)nc3-c3ccccc3)SC2=S)cc1,amide
11003,Remove a benzene_ring from the molecule COc1ccc(CN2CC[NH+](Cn3nc(C4CC4)n(C)c3=S)CC2)cc1.,COc1ccc(CN2CC[NH+](Cn3nc(C4CC4)n(C)c3=S)CC2)cc1,benzene_ring
115435,Please remove a amide from the molecule CCOC(=O)[C@H]1CCCN(C(=O)c2ccc(C)nc2)C1.,CCOC(=O)[C@H]1CCCN(C(=O)c2ccc(C)nc2)C1,amide
219959,Modify the molecule C#CCOc1ccc(/C=C2/C(=O)NN(c3cc(Cl)cc(Cl)c3)C2=O)cc1OCC by removing a amide.,C#CCOc1ccc(/C=C2/C(=O)NN(c3cc(Cl)cc(Cl)c3)C2=O)cc1OCC,amide
172486,Modify the molecule O=C1CC[C@@H](Cn2c(CCCl)nc3cccnc32)N1 by removing a halo.,O=C1CC[C@@H](Cn2c(CCCl)nc3cccnc32)N1,halo
38296,Remove a amide from the molecule COc1ccc2cc(C(=O)NCc3cccc(NC(=O)N4CCCC4)c3)[nH]c2c1.,COc1ccc2cc(C(=O)NCc3cccc(NC(=O)N4CCCC4)c3)[nH]c2c1,amide
119671,Modify the molecule C[C@@H]1C[C@@H]1n1c(CCCl)nc2cc(Br)cnc21 by removing a halo.,C[C@@H]1C[C@@H]1n1c(CCCl)nc2cc(Br)cnc21,halo
153105,Modify the molecule N#Cc1cccc(NC(=O)CN2c3cccc4cccc(c34)S2(=O)=O)c1 by removing a benzene_ring.,N#Cc1cccc(NC(=O)CN2c3cccc4cccc(c34)S2(=O)=O)c1,benzene_ring
88532,Modify the molecule CCn1cc(C[NH+](CC2CC2)[C@H](C)c2ccccc2)cn1 by removing a benzene_ring.,CCn1cc(C[NH+](CC2CC2)[C@H](C)c2ccccc2)cn1,benzene_ring
224456,Modify the molecule CC[NH+]1CCCN(C(=O)[C@@H]2CCC(=O)N(c3ccc(C)c(C)c3)C2)CC1 by removing a benzene_ring.,CC[NH+]1CCCN(C(=O)[C@@H]2CCC(=O)N(c3ccc(C)c(C)c3)C2)CC1,benzene_ring
67007,Remove a benzene_ring from the molecule CC[C@H](C)N(C)C(=O)Nc1ccc(N(C)C)cc1.,CC[C@H](C)N(C)C(=O)Nc1ccc(N(C)C)cc1,benzene_ring
175371,Modify the molecule COC(=O)[C@H](O)C1CC[NH+](CC2=Cc3ccccc3OC2)CC1 by removing a hydroxyl.,COC(=O)[C@H](O)C1CC[NH+](CC2=Cc3ccccc3OC2)CC1,hydroxyl
146953,Please remove a benzene_ring from the molecule Cc1csc(S[C@H](C)C(=O)NC(c2ccccc2)c2ccccc2)n1.,Cc1csc(S[C@H](C)C(=O)NC(c2ccccc2)c2ccccc2)n1,benzene_ring
98587,Remove a amide from the molecule CNC(=O)c1sc2ccccc2c1[C@H]1CCN(C(=O)c2cccc(N(C)C)c2)C1.,CNC(=O)c1sc2ccccc2c1[C@H]1CCN(C(=O)c2cccc(N(C)C)c2)C1,amide
230603,Remove a amide from the molecule Cc1ccc(-n2c(SCC(=O)N3CCC(C)CC3)nc3[nH]nc(C)c3c2=[NH2+])cc1.,Cc1ccc(-n2c(SCC(=O)N3CCC(C)CC3)nc3[nH]nc(C)c3c2=[NH2+])cc1,amide
225188,Please remove a amide from the molecule CN(C(=O)c1ccccc1NC(=O)/C=C/c1ccc(Cl)cc1)C1CCCCC1.,CN(C(=O)c1ccccc1NC(=O)/C=C/c1ccc(Cl)cc1)C1CCCCC1,amide
63245,Modify the molecule Cc1ccc(C(C)(C)C)cc1[S@@](=O)Cc1cn2ccccc2n1 by removing a benzene_ring.,Cc1ccc(C(C)(C)C)cc1[S@@](=O)Cc1cn2ccccc2n1,benzene_ring
226737,Modify the molecule CN(C)C(=O)[C@@H](OC(=O)CCn1nnc2ccccc2c1=O)c1ccccc1 by removing a benzene_ring.,CN(C)C(=O)[C@@H](OC(=O)CCn1nnc2ccccc2c1=O)c1ccccc1,benzene_ring
126672,Remove a amide from the molecule CC(C)NC(=O)C[C@H](C)NC(=O)N(C)[C@@H]1CCc2ccccc2C1.,CC(C)NC(=O)C[C@H](C)NC(=O)N(C)[C@@H]1CCc2ccccc2C1,amide
141863,Please remove a amide from the molecule CCCN1C(=O)C([O-])=C(C(C)=O)[C@H]1c1ccccc1.,CCCN1C(=O)C([O-])=C(C(C)=O)[C@H]1c1ccccc1,amide
14303,Remove a benzene_ring from the molecule COCC(=O)N[C@H](C)c1nc2ccccc2n1Cc1ccc(F)cc1.,COCC(=O)N[C@H](C)c1nc2ccccc2n1Cc1ccc(F)cc1,benzene_ring
52898,Remove a hydroxyl from the molecule CCC[NH+]1CCN([C@H]2CC[C@@](CO)([NH2+]C(C)C)C2)CC1.,CCC[NH+]1CCN([C@H]2CC[C@@](CO)([NH2+]C(C)C)C2)CC1,hydroxyl
162454,Modify the molecule COc1cccc(-n2cc(C(=O)[O-])c3c2[C@H](c2cc(OC)c(OC)c(OC)c2)CC(=O)N3)c1 by removing a benzene_ring.,COc1cccc(-n2cc(C(=O)[O-])c3c2[C@H](c2cc(OC)c(OC)c(OC)c2)CC(=O)N3)c1,benzene_ring
175837,Remove a benzene_ring from the molecule [NH3+][C@H](CC[C@H]1CCOC2(CCOCC2)C1)c1ccccc1.,[NH3+][C@H](CC[C@H]1CCOC2(CCOCC2)C1)c1ccccc1,benzene_ring
147952,Please remove a nitrile from the molecule Cc1cc(SCC(=O)NC2(C#N)CCCCC2)nc2ccccc12.,Cc1cc(SCC(=O)NC2(C#N)CCCCC2)nc2ccccc12,nitrile
15006,Please remove a benzene_ring from the molecule CC(C)Cc1nnc([C@@H](C)[NH+]2CCC(c3ccc(F)cc3)CC2)o1.,CC(C)Cc1nnc([C@@H](C)[NH+]2CCC(c3ccc(F)cc3)CC2)o1,benzene_ring
198802,Please remove a amide from the molecule COC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CSC(C)(C)N1C=O.,COC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CSC(C)(C)N1C=O,amide
148945,Modify the molecule Cc1sc2nc(C[NH+]3CCN(CC(=O)NCCC4=CCCCC4)CC3)[nH]c(=O)c2c1C by removing a amide.,Cc1sc2nc(C[NH+]3CCN(CC(=O)NCCC4=CCCCC4)CC3)[nH]c(=O)c2c1C,amide
50029,Remove a hydroxyl from the molecule C[NH+]1CCC(O)([C@@H]2CCOC3(CCC3)C2)CC1.,C[NH+]1CCC(O)([C@@H]2CCOC3(CCC3)C2)CC1,hydroxyl
40734,Modify the molecule Fc1cc(Br)ccc1NCc1cccnc1Cl by removing a halo.,Fc1cc(Br)ccc1NCc1cccnc1Cl,halo
143151,Modify the molecule CCN(C(=O)Cc1cc(C)[nH]n1)[C@@H]1CC[NH+]([C@@H](C)c2ccccc2)C1 by removing a amide.,CCN(C(=O)Cc1cc(C)[nH]n1)[C@@H]1CC[NH+]([C@@H](C)c2ccccc2)C1,amide
143022,Please remove a amine from the molecule N#C[C@H]1CNCCN1C(=O)c1cccc(O)c1.,N#C[C@H]1CNCCN1C(=O)c1cccc(O)c1,amine
176997,Remove a amide from the molecule C[C@H]1CC(C(=O)NCc2ccc(CN3CCc4ccccc43)cc2)C[C@H](C)O1.,C[C@H]1CC(C(=O)NCc2ccc(CN3CCc4ccccc43)cc2)C[C@H](C)O1,amide
212068,Modify the molecule CCc1nnc(-c2ccc(NC(=O)C(=O)N[C@@H]3CCCC[C@@H]3C)cc2)o1 by removing a benzene_ring.,CCc1nnc(-c2ccc(NC(=O)C(=O)N[C@@H]3CCCC[C@@H]3C)cc2)o1,benzene_ring
133191,Remove a benzene_ring from the molecule CCc1nnc(NC(=O)N[C@@H](C)c2ccc(F)c(F)c2)s1.,CCc1nnc(NC(=O)N[C@@H](C)c2ccc(F)c(F)c2)s1,benzene_ring
138534,Remove a halo from the molecule CCCCNC(=O)N[C@H]1CCCN(c2ccc(OC(F)F)cc2)C1=O.,CCCCNC(=O)N[C@H]1CCCN(c2ccc(OC(F)F)cc2)C1=O,halo
167272,Please remove a amine from the molecule Cc1nsc(Nc2ccc(F)c(F)c2)c1C#N.,Cc1nsc(Nc2ccc(F)c(F)c2)c1C#N,amine
131552,Modify the molecule CC(=O)N(C)c1ccccn1 by removing a amide.,CC(=O)N(C)c1ccccn1,amide
219404,Remove a benzene_ring from the molecule C[C@@H](c1ccccn1)N(C)C(=O)Nc1cccc(C2SCCS2)c1.,C[C@@H](c1ccccn1)N(C)C(=O)Nc1cccc(C2SCCS2)c1,benzene_ring
616,Please remove a hydroxyl from the molecule CCOc1cc(CO)cc(Br)c1OCc1ccccc1F.,CCOc1cc(CO)cc(Br)c1OCc1ccccc1F,hydroxyl
167861,Remove a amide from the molecule Cc1ccsc1/C=N/NC(=O)/C(=C\c1ccc2c(c1)OCO2)NC(=O)c1ccccc1.,Cc1ccsc1/C=N/NC(=O)/C(=C\c1ccc2c(c1)OCO2)NC(=O)c1ccccc1,amide
216704,Remove a halo from the molecule CSc1cccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)c1.,CSc1cccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)c1,halo
2366,Please remove a halo from the molecule Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1.,Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1,halo
56176,Remove a amide from the molecule CCOC(=O)c1nn(-c2ccccc2C)c(=O)cc1NC(=O)c1ccc(Cl)cc1.,CCOC(=O)c1nn(-c2ccccc2C)c(=O)cc1NC(=O)c1ccc(Cl)cc1,amide
38353,Modify the molecule O[C@@H](CN1CCc2sccc2C1)c1ccccc1 by removing a hydroxyl.,O[C@@H](CN1CCc2sccc2C1)c1ccccc1,hydroxyl
53681,Remove a amide from the molecule O=C(Cn1c(=O)sc2cc(S(=O)(=O)N3CCCC3)ccc21)NC1CCCCC1.,O=C(Cn1c(=O)sc2cc(S(=O)(=O)N3CCCC3)ccc21)NC1CCCCC1,amide
220132,Modify the molecule CC(=O)Nc1cc(NC(C)=O)cc(C(=O)Nc2ccc(/C=C\C(=O)c3ccccc3)cc2)c1 by removing a amide.,CC(=O)Nc1cc(NC(C)=O)cc(C(=O)Nc2ccc(/C=C\C(=O)c3ccccc3)cc2)c1,amide
103486,Please remove a amide from the molecule COc1ccc(C(=O)N[C@@H](C(=O)Nc2ncc(C)s2)C(C)C)cc1.,COc1ccc(C(=O)N[C@@H](C(=O)Nc2ncc(C)s2)C(C)C)cc1,amide
123881,Remove a benzene_ring from the molecule CN(c1ccccn1)S(=O)(=O)c1ccc(F)cc1F.,CN(c1ccccn1)S(=O)(=O)c1ccc(F)cc1F,benzene_ring
205585,Please remove a amine from the molecule C/[NH+]=C(/NCc1noc(C)n1)N1CCc2cc(OC)c(OC)cc2C1.,C/[NH+]=C(/NCc1noc(C)n1)N1CCc2cc(OC)c(OC)cc2C1,amine
220130,Please remove a amide from the molecule COc1ccc(CC[NH+](C)[C@H]2CCCN(C(=O)c3ccncc3)C2)cc1OC.,COc1ccc(CC[NH+](C)[C@H]2CCCN(C(=O)c3ccncc3)C2)cc1OC,amide
129196,Remove a amide from the molecule CNC(=O)c1ccccc1NC(=O)[C@H]1CC[NH2+][C@H]1C.,CNC(=O)c1ccccc1NC(=O)[C@H]1CC[NH2+][C@H]1C,amide
107596,Remove a amide from the molecule O=C(NCc1coc(-c2ccccc2)n1)c1cnc([C@H]2CCCO2)s1.,O=C(NCc1coc(-c2ccccc2)n1)c1cnc([C@H]2CCCO2)s1,amide
216061,Modify the molecule CC[S@@](=O)[C@@H]1CCCC[C@@H]1NC(=O)Nc1ccccc1N1CCCCC1 by removing a benzene_ring.,CC[S@@](=O)[C@@H]1CCCC[C@@H]1NC(=O)Nc1ccccc1N1CCCCC1,benzene_ring
149190,Remove a nitro from the molecule Cc1cccc(Nc2ncnc(N3CCCC[C@H]3C)c2[N+](=O)[O-])c1.,Cc1cccc(Nc2ncnc(N3CCCC[C@H]3C)c2[N+](=O)[O-])c1,nitro
240059,Modify the molecule N#C[C@@H]1OC(=O)c2cccc(F)c21 by removing a halo.,N#C[C@@H]1OC(=O)c2cccc(F)c21,halo
71673,Please remove a benzene_ring from the molecule COCC[C@@H]([NH3+])c1ncc(-c2cc(F)cc(F)c2)[nH]1.,COCC[C@@H]([NH3+])c1ncc(-c2cc(F)cc(F)c2)[nH]1,benzene_ring
11067,Please remove a amide from the molecule Cc1cc(C)cc(NC(=O)C(=O)NCc2ncc(C)s2)c1.,Cc1cc(C)cc(NC(=O)C(=O)NCc2ncc(C)s2)c1,amide
83046,Please remove a benzene_ring from the molecule CC[C@@H](NC(=O)NCc1scnc1C)C(C)(C)c1ccccc1.,CC[C@@H](NC(=O)NCc1scnc1C)C(C)(C)c1ccccc1,benzene_ring
219496,Please remove a amine from the molecule O=c1c(N[C@H]2CCC[NH2+]C2)nccn1-c1ccccc1.,O=c1c(N[C@H]2CCC[NH2+]C2)nccn1-c1ccccc1,amine
189280,Modify the molecule COc1ccccc1C[NH2+]CC[C@H]1CCCO1 by removing a benzene_ring.,COc1ccccc1C[NH2+]CC[C@H]1CCCO1,benzene_ring
234047,Please remove a amide from the molecule C[C@H]1CC[C@@H](C)C[NH+]1CC(=O)NC1CCCC1.,C[C@H]1CC[C@@H](C)C[NH+]1CC(=O)NC1CCCC1,amide
117396,Modify the molecule C[C@H](Nc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1[N+](=O)[O-])c1ccc(F)cc1F by removing a halo.,C[C@H](Nc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1[N+](=O)[O-])c1ccc(F)cc1F,halo
16515,Remove a amide from the molecule O=C1c2ccccc2C(=O)N1C[C@H](c1ccco1)[NH+]1CCCCC1.,O=C1c2ccccc2C(=O)N1C[C@H](c1ccco1)[NH+]1CCCCC1,amide
245161,Remove a hydroxyl from the molecule CC(C)n1c[nH+]cc1[C@H](O)[C@@H]1CCCCC[NH2+]1.,CC(C)n1c[nH+]cc1[C@H](O)[C@@H]1CCCCC[NH2+]1,hydroxyl
38155,Modify the molecule CC(C)CC(=O)N[C@@H](CC(=O)[O-])c1ccccc1Cl by removing a benzene_ring.,CC(C)CC(=O)N[C@@H](CC(=O)[O-])c1ccccc1Cl,benzene_ring
127320,Modify the molecule O=C(CSc1ncccc1Cl)N1CCC[C@H]1c1ccc2c(c1)OCCO2 by removing a halo.,O=C(CSc1ncccc1Cl)N1CCC[C@H]1c1ccc2c(c1)OCCO2,halo
160486,Remove a amine from the molecule CN(C)c1ccc([C@H]2Nc3ccc(S(=O)(=O)NCc4ccccc4)cc3[C@@H]3C=CC[C@@H]23)cc1.,CN(C)c1ccc([C@H]2Nc3ccc(S(=O)(=O)NCc4ccccc4)cc3[C@@H]3C=CC[C@@H]23)cc1,amine
27595,Remove a benzene_ring from the molecule CN1CCc2nc[nH]c2C12CC[NH+](Cc1cccc(OC3CCCC3)c1)CC2.,CN1CCc2nc[nH]c2C12CC[NH+](Cc1cccc(OC3CCCC3)c1)CC2,benzene_ring
210211,Please remove a benzene_ring from the molecule Cc1nn(C)c(C)c1CCC[NH2+][C@@H](C)c1ccccc1.,Cc1nn(C)c(C)c1CCC[NH2+][C@@H](C)c1ccccc1,benzene_ring
20033,Please remove a benzene_ring from the molecule CCCOc1ccc(OCCC2CC[NH2+]CC2)cc1.,CCCOc1ccc(OCCC2CC[NH2+]CC2)cc1,benzene_ring
164892,Modify the molecule S=C(NN=C1CCSCC1)NC1CCCCC1 by removing a amine.,S=C(NN=C1CCSCC1)NC1CCCCC1,amine
248653,Remove a benzene_ring from the molecule C[C@@H](Cc1ccc(Cl)cc1)N(C)C(=O)c1ccc2ncccc2c1.,C[C@@H](Cc1ccc(Cl)cc1)N(C)C(=O)c1ccc2ncccc2c1,benzene_ring
8369,Modify the molecule Cc1ccc(F)c(C(=O)NNC(=S)NC[C@@H]2CCCO2)c1 by removing a benzene_ring.,Cc1ccc(F)c(C(=O)NNC(=S)NC[C@@H]2CCCO2)c1,benzene_ring
49912,Remove a benzene_ring from the molecule O=C(NN=C1CCCc2ccccc21)C(O)(c1ccccc1)c1ccccc1.,O=C(NN=C1CCCc2ccccc21)C(O)(c1ccccc1)c1ccccc1,benzene_ring
99506,Please remove a amide from the molecule Cc1nn(-c2ccc(Cl)cc2)cc1C(=O)N(C)CCN1CCOCC1.,Cc1nn(-c2ccc(Cl)cc2)cc1C(=O)N(C)CCN1CCOCC1,amide
35724,Modify the molecule CC(C)CNC(=O)NC(=O)CSc1nc2ccccc2c(=O)n1C1CC1 by removing a amide.,CC(C)CNC(=O)NC(=O)CSc1nc2ccccc2c(=O)n1C1CC1,amide
134342,Modify the molecule CCOC(=O)c1nn(CC)c2c1CN(C(=O)C1=CC3=CC=N[C@@H]3C=C1)CC2 by removing a amide.,CCOC(=O)c1nn(CC)c2c1CN(C(=O)C1=CC3=CC=N[C@@H]3C=C1)CC2,amide
167887,Modify the molecule Cc1c(Cl)c(-c2ccc(N(C)S(C)(=O)=O)cc2)nc2cc3c(cc12)OCO3 by removing a halo.,Cc1c(Cl)c(-c2ccc(N(C)S(C)(=O)=O)cc2)nc2cc3c(cc12)OCO3,halo
181887,Please remove a benzene_ring from the molecule COc1cccc(-c2cc3c(N4CCc5ccccc5C4)nccn3n2)c1.,COc1cccc(-c2cc3c(N4CCc5ccccc5C4)nccn3n2)c1,benzene_ring
142223,Remove a benzene_ring from the molecule CN(Cc1ccccc1C(F)(F)F)C(=O)NCCOc1ccccc1.,CN(Cc1ccccc1C(F)(F)F)C(=O)NCCOc1ccccc1,benzene_ring
177111,Remove a amide from the molecule Cc1ccnc(NNC(=O)c2ccc(S(=O)(=O)N(C)C)cc2)c1.,Cc1ccnc(NNC(=O)c2ccc(S(=O)(=O)N(C)C)cc2)c1,amide
241225,Please remove a benzene_ring from the molecule N#C[C@H]1COCCN1Cc1cccc(-c2ccccn2)c1.,N#C[C@H]1COCCN1Cc1cccc(-c2ccccn2)c1,benzene_ring
90270,Please remove a amide from the molecule Cc1ccncc1[N-]S(=O)(=O)c1c[nH]c(C(=O)N2CCCC2)c1.,Cc1ccncc1[N-]S(=O)(=O)c1c[nH]c(C(=O)N2CCCC2)c1,amide
116102,Modify the molecule COC(=O)[C@H](N[C@H](C)c1cccc(-n2cccn2)c1)c1ccccc1F by removing a halo.,COC(=O)[C@H](N[C@H](C)c1cccc(-n2cccn2)c1)c1ccccc1F,halo
204012,Remove a halo from the molecule C[C@H](NC(=O)Cc1cccc(F)c1F)C1(N2CCOCC2)CCCC1.,C[C@H](NC(=O)Cc1cccc(F)c1F)C1(N2CCOCC2)CCCC1,halo
79641,Modify the molecule CC[NH+](C)CC[C@@H](c1ccccc1)[NH+]1CCOCC1 by removing a benzene_ring.,CC[NH+](C)CC[C@@H](c1ccccc1)[NH+]1CCOCC1,benzene_ring
168748,Please remove a halo from the molecule CC(C)(C)CC(=O)Nc1ccc(F)cc1F.,CC(C)(C)CC(=O)Nc1ccc(F)cc1F,halo
109135,Modify the molecule CCOC(=O)c1c(/C=C/C(=O)N(C)C2(C#N)CCC2)c(C)n(CC)c1C by removing a amide.,CCOC(=O)c1c(/C=C/C(=O)N(C)C2(C#N)CCC2)c(C)n(CC)c1C,amide
98640,Modify the molecule COc1ccc(OC)c2nc(Cl)c(CCN3C(=O)c4ccccc4C3=O)cc12 by removing a halo.,COc1ccc(OC)c2nc(Cl)c(CCN3C(=O)c4ccccc4C3=O)cc12,halo
15982,Remove a amide from the molecule CCn1c(COc2cccc3cccnc23)nnc1SCC(N)=O.,CCn1c(COc2cccc3cccnc23)nnc1SCC(N)=O,amide
238090,Modify the molecule C[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)N(C)C1CCOCC1 by removing a benzene_ring.,C[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)N(C)C1CCOCC1,benzene_ring
117212,Remove a amide from the molecule COCc1ccc(C(=O)N[C@H]2C[C@@](C)(OC)C2(C)C)o1.,COCc1ccc(C(=O)N[C@H]2C[C@@](C)(OC)C2(C)C)o1,amide
131407,Please remove a amide from the molecule CC[C@H]1CN(C(C)=O)CC[C@H]1CC(=O)Nc1nccs1.,CC[C@H]1CN(C(C)=O)CC[C@H]1CC(=O)Nc1nccs1,amide
69875,Modify the molecule CCN(CC)S(=O)(=O)c1ccc(NC(=O)C2CCCC2)cc1 by removing a amide.,CCN(CC)S(=O)(=O)c1ccc(NC(=O)C2CCCC2)cc1,amide
72927,Modify the molecule C[C@@H]([NH2+]CC1(CO)CCOCC1)c1cc(F)c(F)c(F)c1 by removing a halo.,C[C@@H]([NH2+]CC1(CO)CCOCC1)c1cc(F)c(F)c(F)c1,halo
204499,Modify the molecule O=C([C@H]1SCCc2sccc21)N1CCO[C@H](c2ccc(F)cc2)C1 by removing a halo.,O=C([C@H]1SCCc2sccc21)N1CCO[C@H](c2ccc(F)cc2)C1,halo
56665,Modify the molecule CC[C@H](C)[C@@H](C(=O)Nc1ccn(C)n1)N1C(=O)c2ccccc2C1=O by removing a amide.,CC[C@H](C)[C@@H](C(=O)Nc1ccn(C)n1)N1C(=O)c2ccccc2C1=O,amide
13930,Please remove a amine from the molecule CCNc1cc[nH+]c(CN2CCO[C@H]3CCCC[C@@H]32)c1.,CCNc1cc[nH+]c(CN2CCO[C@H]3CCCC[C@@H]32)c1,amine
53558,Modify the molecule COc1ccccc1NC(=O)CSc1nnc(-c2ccccn2)o1 by removing a amide.,COc1ccccc1NC(=O)CSc1nnc(-c2ccccn2)o1,amide
242568,Please remove a benzene_ring from the molecule Cc1noc(C)c1CCCNC(=O)Nc1cccc(C(C)C)c1.,Cc1noc(C)c1CCCNC(=O)Nc1cccc(C(C)C)c1,benzene_ring
10298,Remove a amide from the molecule CN(C(=O)CSc1nnc(-c2ccccc2F)o1)c1ccccc1.,CN(C(=O)CSc1nnc(-c2ccccc2F)o1)c1ccccc1,amide
59131,Remove a hydroxyl from the molecule Cc1nnc(SC[C@@H](O)CN2CCOCC2)s1.,Cc1nnc(SC[C@@H](O)CN2CCOCC2)s1,hydroxyl
243091,Remove a halo from the molecule CC(C)Cn1ncc(C(=O)N(C)[C@@H](C)Cc2ccsc2)c1C(F)F.,CC(C)Cn1ncc(C(=O)N(C)[C@@H](C)Cc2ccsc2)c1C(F)F,halo
194198,Please remove a amine from the molecule CC(=O)c1c(C)nsc1N[C@H](C)c1ccc(C)cc1.,CC(=O)c1c(C)nsc1N[C@H](C)c1ccc(C)cc1,amine
18798,Modify the molecule CCc1ccc(NC(=O)C(=O)NCC2(C)CCCC2)cc1[N+](=O)[O-] by removing a nitro.,CCc1ccc(NC(=O)C(=O)NCC2(C)CCCC2)cc1[N+](=O)[O-],nitro
135449,Please remove a amine from the molecule C/[NH+]=C(/NCCc1c[nH]c2cc(C)ccc12)NCc1cn2c(C)cccc2[nH+]1.,C/[NH+]=C(/NCCc1c[nH]c2cc(C)ccc12)NCc1cn2c(C)cccc2[nH+]1,amine
165793,Remove a halo from the molecule COC(=O)c1ccc2c(c1C)N[C@H](c1cc(Br)c(OC)c(OC)c1)[C@H]1CC=C[C@H]21.,COC(=O)c1ccc2c(c1C)N[C@H](c1cc(Br)c(OC)c(OC)c1)[C@H]1CC=C[C@H]21,halo
87066,Remove a amide from the molecule COCCN(Cc1ccco1)C(=O)c1cc2cc([N+](=O)[O-])ccc2s1.,COCCN(Cc1ccco1)C(=O)c1cc2cc([N+](=O)[O-])ccc2s1,amide
116858,Modify the molecule CCOc1ccc2[nH]c(=O)c(CNc3ccc(N4CCc5ccccc5C4)cc3)cc2c1 by removing a amine.,CCOc1ccc2[nH]c(=O)c(CNc3ccc(N4CCc5ccccc5C4)cc3)cc2c1,amine
198065,Remove a benzene_ring from the molecule CN(Cc1nnc2n1CCC2)C(=O)c1ccc(S(C)(=O)=O)cc1.,CN(Cc1nnc2n1CCC2)C(=O)c1ccc(S(C)(=O)=O)cc1,benzene_ring
147864,Please remove a halo from the molecule COc1cc(-c2noc(CN3C[C@H](C)c4ccccc43)n2)ccc1OC(F)F.,COc1cc(-c2noc(CN3C[C@H](C)c4ccccc43)n2)ccc1OC(F)F,halo
33899,Remove a amide from the molecule CCC(CC)N(CC(C)C)C(=O)[C@H]1CC[C@@H]([NH3+])C1.,CCC(CC)N(CC(C)C)C(=O)[C@H]1CC[C@@H]([NH3+])C1,amide
28564,Remove a amide from the molecule CN(CC(=O)N1N=C(c2ccc(Cl)cc2)C[C@@H]1c1ccco1)S(=O)(=O)c1cccs1.,CN(CC(=O)N1N=C(c2ccc(Cl)cc2)C[C@@H]1c1ccco1)S(=O)(=O)c1cccs1,amide
89014,Remove a amine from the molecule CN(C(=O)c1cccc(NCC(=O)NCc2ccco2)c1)c1ccccc1.,CN(C(=O)c1cccc(NCC(=O)NCc2ccco2)c1)c1ccccc1,amine
7136,Remove a hydroxyl from the molecule Cc1ccc(CC(=O)NNc2c(Cl)cccc2Cl)cc1O.,Cc1ccc(CC(=O)NNc2c(Cl)cccc2Cl)cc1O,hydroxyl
223264,Remove a thiol from the molecule SCC1(COC2CCCC2)CC1.,SCC1(COC2CCCC2)CC1,thiol
232768,Please remove a halo from the molecule COC(=O)c1cc(NC(=O)C2CCN(C(=O)c3ccccc3Cl)CC2)cc(C(=O)OC)c1.,COC(=O)c1cc(NC(=O)C2CCN(C(=O)c3ccccc3Cl)CC2)cc(C(=O)OC)c1,halo
234248,Modify the molecule C[NH+]1CCC[C@H](C(=O)NCc2ccc[nH]2)C1 by removing a amide.,C[NH+]1CCC[C@H](C(=O)NCc2ccc[nH]2)C1,amide
62252,Remove a benzene_ring from the molecule Cc1ccc([C@@H](C)N(C)C(=O)c2nnn[n-]2)cc1.,Cc1ccc([C@@H](C)N(C)C(=O)c2nnn[n-]2)cc1,benzene_ring
61692,Remove a amide from the molecule Cc1ccc(C)c(NC(=O)c2ncccc2OCC(F)(F)F)c1.,Cc1ccc(C)c(NC(=O)c2ncccc2OCC(F)(F)F)c1,amide
247910,Please remove a benzene_ring from the molecule COc1ccc([C@H]2CC(=O)C=C(N)C2)cc1.,COc1ccc([C@H]2CC(=O)C=C(N)C2)cc1,benzene_ring
62350,Modify the molecule COCCn1c(C)cc(/C=C(/C#N)C(=O)N[C@H]2CCCNC2=O)c1C by removing a nitrile.,COCCn1c(C)cc(/C=C(/C#N)C(=O)N[C@H]2CCCNC2=O)c1C,nitrile
99070,Modify the molecule C[C@H](Oc1ccc(Cl)cc1Cl)C(=O)NNC(=O)[C@H]1CCCC[C@H]1C(=O)[O-] by removing a halo.,C[C@H](Oc1ccc(Cl)cc1Cl)C(=O)NNC(=O)[C@H]1CCCC[C@H]1C(=O)[O-],halo
244156,Please remove a benzene_ring from the molecule Cc1cc(C2=N/C(=C\c3cc4c(cc3Cl)OCO4)C(=O)O2)ccc1Br.,Cc1cc(C2=N/C(=C\c3cc4c(cc3Cl)OCO4)C(=O)O2)ccc1Br,benzene_ring
60282,Remove a amide from the molecule O=C(Nc1nccs1)[C@H]1c2ccccc2C(=O)N(C2CCCC2)C12CCCC2.,O=C(Nc1nccs1)[C@H]1c2ccccc2C(=O)N(C2CCCC2)C12CCCC2,amide
156840,Remove a amide from the molecule O=C(NC[C@H](c1cccs1)[NH+]1CCCC1)[C@@H]1CCCN1C(=O)c1ccc(Br)cc1.,O=C(NC[C@H](c1cccs1)[NH+]1CCCC1)[C@@H]1CCCN1C(=O)c1ccc(Br)cc1,amide
99808,Please remove a amide from the molecule CCNC(=O)c1ccc([NH+]2C[C@@H](C)[C@H](C(=O)[O-])C2)[nH+]n1.,CCNC(=O)c1ccc([NH+]2C[C@@H](C)[C@H](C(=O)[O-])C2)[nH+]n1,amide
76461,Modify the molecule C[NH+]1C[C@@H](c2ccc([N+](=O)[O-])cc2)[C@@H](C(=O)c2ccc(F)cc2)[C@@]12C(=O)Nc1ccccc12 by removing a nitro.,C[NH+]1C[C@@H](c2ccc([N+](=O)[O-])cc2)[C@@H](C(=O)c2ccc(F)cc2)[C@@]12C(=O)Nc1ccccc12,nitro
88769,Remove a amide from the molecule O=C([O-])c1ccc(N2C(=O)/C(=C/C3=c4ccccc4=[NH+]C3)SC2=S)cc1O.,O=C([O-])c1ccc(N2C(=O)/C(=C/C3=c4ccccc4=[NH+]C3)SC2=S)cc1O,amide
56395,Please remove a halo from the molecule O=C(CSc1nnc(-c2cccs2)n1C1CC1)Nc1cc2[nH]c(=O)[nH]c2cc1Br.,O=C(CSc1nnc(-c2cccs2)n1C1CC1)Nc1cc2[nH]c(=O)[nH]c2cc1Br,halo
197167,Please remove a amide from the molecule O=C(NCC1CCCCC1)c1cccc(NC(=O)c2scc3c2OCO3)c1.,O=C(NCC1CCCCC1)c1cccc(NC(=O)c2scc3c2OCO3)c1,amide
71068,Please remove a hydroxyl from the molecule O=C(CCCNC(=O)c1cccs1)NC[C@@]1(O)CCSC1.,O=C(CCCNC(=O)c1cccs1)NC[C@@]1(O)CCSC1,hydroxyl
98251,Remove a halo from the molecule COc1c(Cl)cc(C(=O)OCc2nc(C)no2)cc1Cl.,COc1c(Cl)cc(C(=O)OCc2nc(C)no2)cc1Cl,halo
134822,Please remove a amide from the molecule COc1cc(CC(=O)Nc2ccc(C)cc2OC)ccc1C.,COc1cc(CC(=O)Nc2ccc(C)cc2OC)ccc1C,amide
166474,Please remove a nitrile from the molecule N#CCCCSc1nnc(-c2ccccc2)n1-c1ccccc1.,N#CCCCSc1nnc(-c2ccccc2)n1-c1ccccc1,nitrile
45146,Remove a hydroxyl from the molecule COc1cccc([C@H](C)CC(=O)Nc2cnc(-c3cccc(O)c3)nc2)c1.,COc1cccc([C@H](C)CC(=O)Nc2cnc(-c3cccc(O)c3)nc2)c1,hydroxyl
123259,Modify the molecule O=C(CNC(=O)C(=O)Nc1ccccc1C[NH+]1CCCC1)NC1CC1 by removing a benzene_ring.,O=C(CNC(=O)C(=O)Nc1ccccc1C[NH+]1CCCC1)NC1CC1,benzene_ring
206350,Remove a hydroxyl from the molecule Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)N[C@H]1CCCC[C@@H]1CO.,Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)N[C@H]1CCCC[C@@H]1CO,hydroxyl
163345,Remove a amide from the molecule CC(=O)NCCc1nc2ccccc2n1CC(=O)NC[C@H]1CCCO1.,CC(=O)NCCc1nc2ccccc2n1CC(=O)NC[C@H]1CCCO1,amide
238412,Remove a nitrile from the molecule Cc1nc([O-])c(C#N)cc1C(=O)N1CCC[C@@H](c2[nH+]ccn2CC(N)=O)C1.,Cc1nc([O-])c(C#N)cc1C(=O)N1CCC[C@@H](c2[nH+]ccn2CC(N)=O)C1,nitrile
110180,Please remove a amide from the molecule CNC(=O)CC1CCN(C(=O)N[C@@H]2C[C@H]2c2ccccc2F)CC1.,CNC(=O)CC1CCN(C(=O)N[C@@H]2C[C@H]2c2ccccc2F)CC1,amide
200810,Please remove a halo from the molecule CCCNC(=O)CNC(=O)N[C@H](CC)c1ccc(C)c(F)c1.,CCCNC(=O)CNC(=O)N[C@H](CC)c1ccc(C)c(F)c1,halo
191953,Please remove a halo from the molecule Nc1ccc(S[C@H]2CCC[C@@H]2O)cc1Cl.,Nc1ccc(S[C@H]2CCC[C@@H]2O)cc1Cl,halo
121105,Remove a amide from the molecule CC(C)OCCC(=O)Nc1cccc(C(=O)NC(C)(C)C)c1.,CC(C)OCCC(=O)Nc1cccc(C(=O)NC(C)(C)C)c1,amide
52959,Remove a amide from the molecule CCc1c(C)nc(-n2nc(-c3ccco3)cc2NC(=O)COc2cccc3c2OC(C)(C)C3)nc1[O-].,CCc1c(C)nc(-n2nc(-c3ccco3)cc2NC(=O)COc2cccc3c2OC(C)(C)C3)nc1[O-],amide
62912,Remove a benzene_ring from the molecule Cc1c(NCC2(c3ccc(F)cc3)CCOCC2)cc(C#N)cc1[N+](=O)[O-].,Cc1c(NCC2(c3ccc(F)cc3)CCOCC2)cc(C#N)cc1[N+](=O)[O-],benzene_ring
90971,Remove a amide from the molecule CC1CCN(S(=O)(=O)c2ccc(-c3noc(CCC(=O)Nc4cccc(F)c4)n3)cc2)CC1.,CC1CCN(S(=O)(=O)c2ccc(-c3noc(CCC(=O)Nc4cccc(F)c4)n3)cc2)CC1,amide
46982,Remove a amide from the molecule O=C(c1ccc(-c2ccc(F)cc2)o1)N(Cc1ccccn1)C1CC1.,O=C(c1ccc(-c2ccc(F)cc2)o1)N(Cc1ccccn1)C1CC1,amide
127222,Please remove a hydroxyl from the molecule CCOCCN(C)C(=O)NCc1ccc(O)c(Br)c1.,CCOCCN(C)C(=O)NCc1ccc(O)c(Br)c1,hydroxyl
210894,Please remove a amide from the molecule O=C(NC(=S)NNC(=O)c1cccs1)c1cc2ccccc2o1.,O=C(NC(=S)NNC(=O)c1cccs1)c1cc2ccccc2o1,amide
161773,Modify the molecule O=C(NC[C@@H](Cc1ccccc1)NC(=O)c1cnccn1)c1cnccn1 by removing a benzene_ring.,O=C(NC[C@@H](Cc1ccccc1)NC(=O)c1cnccn1)c1cnccn1,benzene_ring
174105,Please remove a amide from the molecule O=C(Cc1ccccc1Cl)NCc1ccnc(-n2cccn2)c1.,O=C(Cc1ccccc1Cl)NCc1ccnc(-n2cccn2)c1,amide
157825,Please remove a benzene_ring from the molecule COCCc1ccc(OS(=O)(=O)c2ccc3c(c2)CCCC3)cc1.,COCCc1ccc(OS(=O)(=O)c2ccc3c(c2)CCCC3)cc1,benzene_ring
242281,Modify the molecule CC(C)(CNc1ccc(C#N)c([N+](=O)[O-])c1)S(C)(=O)=O by removing a amine.,CC(C)(CNc1ccc(C#N)c([N+](=O)[O-])c1)S(C)(=O)=O,amine
125896,Modify the molecule Cc1cc(N[C@@H](C(N)=O)c2ccccc2)ccc1C(=O)NC(C)C by removing a amide.,Cc1cc(N[C@@H](C(N)=O)c2ccccc2)ccc1C(=O)NC(C)C,amide
182665,Remove a halo from the molecule COc1ccc(CN2CC[C@H]3[C@H](CCC[NH+]3C3CC3)C2)cc1OC(F)F.,COc1ccc(CN2CC[C@H]3[C@H](CCC[NH+]3C3CC3)C2)cc1OC(F)F,halo
112270,Modify the molecule CC[NH+](CC)c1ccc([N-]S(=O)(=O)c2ccc(Cl)s2)cc1C(=O)[O-] by removing a benzene_ring.,CC[NH+](CC)c1ccc([N-]S(=O)(=O)c2ccc(Cl)s2)cc1C(=O)[O-],benzene_ring
129583,Modify the molecule C[C@H]1CCC[C@@H](NC(=O)c2ccc3c([O-])n(C)c(=S)nc3c2)[C@@H]1C by removing a amide.,C[C@H]1CCC[C@@H](NC(=O)c2ccc3c([O-])n(C)c(=S)nc3c2)[C@@H]1C,amide
167244,Modify the molecule CC(C)CN1C(=O)/C(=C2\C(=O)N(CC(=O)Nc3ccccc3Cl)c3ccccc32)SC1=S by removing a halo.,CC(C)CN1C(=O)/C(=C2\C(=O)N(CC(=O)Nc3ccccc3Cl)c3ccccc32)SC1=S,halo
13293,Please remove a halo from the molecule O=C1O[C@H](/C=N/c2ccc(C(F)(F)F)cc2)c2ccccc21.,O=C1O[C@H](/C=N/c2ccc(C(F)(F)F)cc2)c2ccccc21,halo
239955,Please remove a amine from the molecule CCOc1ccc([C@H]2C3=C(CCCC3=O)Nc3c(C(=O)Nc4ccc(F)cc4)cnn32)cc1.,CCOc1ccc([C@H]2C3=C(CCCC3=O)Nc3c(C(=O)Nc4ccc(F)cc4)cnn32)cc1,amine
162141,Modify the molecule C[C@H](Cc1ccc(Cl)cc1)N(C)C(=O)c1c[nH]c2nccc(Cl)c12 by removing a amide.,C[C@H](Cc1ccc(Cl)cc1)N(C)C(=O)c1c[nH]c2nccc(Cl)c12,amide
92841,Modify the molecule CC[C@@H](C(=O)NNC(=O)N[C@@H](c1ccccn1)C(C)C)c1ccccc1 by removing a benzene_ring.,CC[C@@H](C(=O)NNC(=O)N[C@@H](c1ccccn1)C(C)C)c1ccccc1,benzene_ring
231809,Remove a amine from the molecule CCc1cc[n+](/C(C(=O)c2ccc3c(c2)OCO3)=C(/[S-])NC2CC2)cc1.,CCc1cc[n+](/C(C(=O)c2ccc3c(c2)OCO3)=C(/[S-])NC2CC2)cc1,amine
128945,Remove a amide from the molecule O=C(c1cccc(Cl)c1)N(CCN1CCOCC1)c1nc2c(F)cc(F)cc2s1.,O=C(c1cccc(Cl)c1)N(CCN1CCOCC1)c1nc2c(F)cc(F)cc2s1,amide
175713,Please remove a amide from the molecule COCCCNC(=O)N1CCC[NH+](CC(=O)N(C)C)CC1.,COCCCNC(=O)N1CCC[NH+](CC(=O)N(C)C)CC1,amide
63829,Modify the molecule CC[C@H](C)[C@H](O)CNC(=O)C(=O)Nc1ccc(C)nc1Br by removing a amide.,CC[C@H](C)[C@H](O)CNC(=O)C(=O)Nc1ccc(C)nc1Br,amide
104165,Please remove a amide from the molecule CCO[C@H](C)c1nc(C[NH+](C)CC(N)=O)cs1.,CCO[C@H](C)c1nc(C[NH+](C)CC(N)=O)cs1,amide
102012,Please remove a amide from the molecule CCN1C(=O)Cc2ccccc2[C@H]1C(=O)NCCC1=CCCCC1.,CCN1C(=O)Cc2ccccc2[C@H]1C(=O)NCCC1=CCCCC1,amide
142588,Remove a hydroxyl from the molecule O=C(NC[C@@H](O)c1ccoc1)[C@@H]1COc2ccccc2O1.,O=C(NC[C@@H](O)c1ccoc1)[C@@H]1COc2ccccc2O1,hydroxyl
16353,Remove a nitrile from the molecule CC(C)NC(=O)/C(C#N)=C(/[O-])[C@H]1C[C@@H]1c1ccc(C(C)C)cc1.,CC(C)NC(=O)/C(C#N)=C(/[O-])[C@H]1C[C@@H]1c1ccc(C(C)C)cc1,nitrile
111613,Please remove a amide from the molecule C[C@@H](Sc1nnc2ccc(C(F)(F)F)cn12)C(=O)N(C)C.,C[C@@H](Sc1nnc2ccc(C(F)(F)F)cn12)C(=O)N(C)C,amide
56345,Please remove a amine from the molecule Cc1ccc(C)c(NC(=S)NC[C@@H](c2cccnc2)N2CCOCC2)c1.,Cc1ccc(C)c(NC(=S)NC[C@@H](c2cccnc2)N2CCOCC2)c1,amine
18667,Remove a hydroxyl from the molecule C/C=C(/C)C(=O)O[C@H]1[C@@H](O[C@@]2(C)CC[C@@H](O)[C@@]3(C)CC=C(C(C)C)C[C@@H]23)O[C@H](C)[C@H](O)[C@H]1O.,C/C=C(/C)C(=O)O[C@H]1[C@@H](O[C@@]2(C)CC[C@@H](O)[C@@]3(C)CC=C(C(C)C)C[C@@H]23)O[C@H](C)[C@H](O)[C@H]1O,hydroxyl
157191,Please remove a benzene_ring from the molecule COc1cc(C[NH+](C)CCn2cnnc2)cc(Cl)c1OC.,COc1cc(C[NH+](C)CCn2cnnc2)cc(Cl)c1OC,benzene_ring
38920,Please remove a halo from the molecule C[C@@H](NC(=O)[C@H]1C[C@@H]1c1ccco1)c1noc(-c2ccc(Cl)cc2)n1.,C[C@@H](NC(=O)[C@H]1C[C@@H]1c1ccco1)c1noc(-c2ccc(Cl)cc2)n1,halo
86943,Please remove a amide from the molecule CC(=O)N1CCCc2cc(NC(=O)[C@@H](C)Cc3c(C)n[nH]c3C)ccc21.,CC(=O)N1CCCc2cc(NC(=O)[C@@H](C)Cc3c(C)n[nH]c3C)ccc21,amide
57634,Please remove a amide from the molecule CC1(C)Cc2c(cnn2-c2ccc(F)cc2)[C@@H](NC(=O)CCC(F)(F)F)C1.,CC1(C)Cc2c(cnn2-c2ccc(F)cc2)[C@@H](NC(=O)CCC(F)(F)F)C1,amide
244511,Modify the molecule Cc1occc1COC(=O)c1cccnc1OCC(F)(F)F by removing a halo.,Cc1occc1COC(=O)c1cccnc1OCC(F)(F)F,halo
26592,Please remove a benzene_ring from the molecule C[NH2+][C@@H](CSc1ccc(Cl)cc1)C1CC1.,C[NH2+][C@@H](CSc1ccc(Cl)cc1)C1CC1,benzene_ring
63744,Please remove a amide from the molecule COc1ccc([C@H]2c3nc[nH]c3CCN2C(=O)c2c(C)nc3c(C)cccn23)cc1.,COc1ccc([C@H]2c3nc[nH]c3CCN2C(=O)c2c(C)nc3c(C)cccn23)cc1,amide
178100,Remove a benzene_ring from the molecule C/C(=N\NC(=O)CSc1ccc(Cl)cc1)c1ccc(Br)cc1.,C/C(=N\NC(=O)CSc1ccc(Cl)cc1)c1ccc(Br)cc1,benzene_ring
164909,Please remove a benzene_ring from the molecule Cc1cc(Br)cc([N+](=O)[O-])c1O[C@@H]1CC(=O)C12CCCC2.,Cc1cc(Br)cc([N+](=O)[O-])c1O[C@@H]1CC(=O)C12CCCC2,benzene_ring
82365,Modify the molecule COCC1=C2[C@H](c3cc(OC)ccc3OC)C(C#N)=C(N)O[C@H]2N=N1 by removing a benzene_ring.,COCC1=C2[C@H](c3cc(OC)ccc3OC)C(C#N)=C(N)O[C@H]2N=N1,benzene_ring
240634,Remove a benzene_ring from the molecule CC[C@@H](Oc1cc(Cl)ccc1Cl)C(=O)NNC(=O)[C@H]1[C@@H](C(=O)[O-])[C@H]2CC[C@@H]1C2.,CC[C@@H](Oc1cc(Cl)ccc1Cl)C(=O)NNC(=O)[C@H]1[C@@H](C(=O)[O-])[C@H]2CC[C@@H]1C2,benzene_ring
20516,Please remove a amide from the molecule C=CCNC(=O)c1ccc(NC(=O)c2ccc3[nH]cnc3c2)cc1.,C=CCNC(=O)c1ccc(NC(=O)c2ccc3[nH]cnc3c2)cc1,amide
222404,Modify the molecule CNC(=O)/C=C/c1ccc(OC(F)F)cc1OC(F)F by removing a benzene_ring.,CNC(=O)/C=C/c1ccc(OC(F)F)cc1OC(F)F,benzene_ring
115485,Please remove a benzene_ring from the molecule CSc1ccc([C@H](O)c2cc(C)c(Cl)cc2C)cc1.,CSc1ccc([C@H](O)c2cc(C)c(Cl)cc2C)cc1,benzene_ring
89866,Modify the molecule C[C@@H](c1ccccc1F)N(C)C(=O)CN(C)C(=O)c1ccccc1 by removing a halo.,C[C@@H](c1ccccc1F)N(C)C(=O)CN(C)C(=O)c1ccccc1,halo
103517,Remove a benzene_ring from the molecule COc1cc(OC)c(C[NH+]2CC[C@H](C)[C@@H](n3ccnc3)C2)c(OC)c1.,COc1cc(OC)c(C[NH+]2CC[C@H](C)[C@@H](n3ccnc3)C2)c(OC)c1,benzene_ring
163614,Modify the molecule COc1ccc([C@@H]2C[C@@H](c3ccc(Cl)c(Cl)c3)Nc3nc(N)nn32)cc1OC by removing a benzene_ring.,COc1ccc([C@@H]2C[C@@H](c3ccc(Cl)c(Cl)c3)Nc3nc(N)nn32)cc1OC,benzene_ring
221454,Modify the molecule C[C@H](c1ccccc1-n1cccn1)n1ccnc1-c1ccco1 by removing a benzene_ring.,C[C@H](c1ccccc1-n1cccn1)n1ccnc1-c1ccco1,benzene_ring
241131,Modify the molecule Cc1cnc2c(c1)N(C(=O)c1ccc(C(F)(F)F)nc1)CCO2 by removing a amide.,Cc1cnc2c(c1)N(C(=O)c1ccc(C(F)(F)F)nc1)CCO2,amide
236975,Remove a benzene_ring from the molecule COc1ccc(-c2ccc(SCc3ccc(F)cc3)nn2)cc1.,COc1ccc(-c2ccc(SCc3ccc(F)cc3)nn2)cc1,benzene_ring
9864,Remove a benzene_ring from the molecule CC(C)Sc1ccccc1C(=O)NCc1ccccn1.,CC(C)Sc1ccccc1C(=O)NCc1ccccn1,benzene_ring
136211,Remove a halo from the molecule O=C(Cc1csc(-c2ccccc2Cl)n1)N[C@H]1CCCNC1=O.,O=C(Cc1csc(-c2ccccc2Cl)n1)N[C@H]1CCCNC1=O,halo
148143,Modify the molecule CC1=NN(c2nc(-c3ccccc3)cs2)C(=O)/C1=N/Nc1cccc([N+](=O)[O-])c1C by removing a amine.,CC1=NN(c2nc(-c3ccccc3)cs2)C(=O)/C1=N/Nc1cccc([N+](=O)[O-])c1C,amine
70115,Please remove a halo from the molecule CCc1ccc(Cl)c(CC)c1NC(=O)[C@H]1CS[C@@]2(C)CCC(=O)N12.,CCc1ccc(Cl)c(CC)c1NC(=O)[C@H]1CS[C@@]2(C)CCC(=O)N12,halo
124757,Modify the molecule COc1ccc(-c2nc(NC3CC[NH2+]CC3)cc(-c3ccncc3)n2)cc1 by removing a benzene_ring.,COc1ccc(-c2nc(NC3CC[NH2+]CC3)cc(-c3ccncc3)n2)cc1,benzene_ring
167678,Modify the molecule C/C(CCc1ccccc1)=N\NC(=O)c1ccc(CN2CCOCC2)cc1 by removing a amide.,C/C(CCc1ccccc1)=N\NC(=O)c1ccc(CN2CCOCC2)cc1,amide
214822,Modify the molecule CCOc1ccc([C@@]2(O)CCCS[C@H]2C)cc1OCC by removing a benzene_ring.,CCOc1ccc([C@@]2(O)CCCS[C@H]2C)cc1OCC,benzene_ring
40207,Please remove a amide from the molecule COCc1ccccc1C(=O)NC[C@H]1C[C@@]12CCc1ccccc12.,COCc1ccccc1C(=O)NC[C@H]1C[C@@]12CCc1ccccc12,amide
50232,Modify the molecule CCc1nn(C)cc1CNC(=O)Nc1ccc(OC2CCOCC2)c(C)c1 by removing a benzene_ring.,CCc1nn(C)cc1CNC(=O)Nc1ccc(OC2CCOCC2)c(C)c1,benzene_ring
98191,Please remove a amine from the molecule NC(=O)[C@@H](NCc1ccc(OC2CCCC2)nc1)c1ccccc1.,NC(=O)[C@@H](NCc1ccc(OC2CCCC2)nc1)c1ccccc1,amine
121095,Please remove a halo from the molecule CCn1nccc1[C@@H](C)[NH2+]Cc1cc(C(F)(F)F)n[nH]1.,CCn1nccc1[C@@H](C)[NH2+]Cc1cc(C(F)(F)F)n[nH]1,halo
73769,Remove a amide from the molecule Cc1ccc(NC(=O)CSc2nnc3c(Cl)cc(C(F)(F)F)cn23)c(Cl)c1.,Cc1ccc(NC(=O)CSc2nnc3c(Cl)cc(C(F)(F)F)cn23)c(Cl)c1,amide
101778,Modify the molecule COCCn1c(C(=O)NCCN2CCN(C(C)=O)CC2)cc2ccccc21 by removing a amide.,COCCn1c(C(=O)NCCN2CCN(C(C)=O)CC2)cc2ccccc21,amide
51446,Remove a halo from the molecule CCC(CC)(C[NH3+])NC(=O)Cc1ccc(F)c(F)c1.,CCC(CC)(C[NH3+])NC(=O)Cc1ccc(F)c(F)c1,halo
218089,Modify the molecule O=C(Cn1nnc(-c2ccccc2Cl)n1)N/N=C/c1cc(Cl)ccc1O by removing a amide.,O=C(Cn1nnc(-c2ccccc2Cl)n1)N/N=C/c1cc(Cl)ccc1O,amide
182858,Remove a amine from the molecule O=C(OCC(=O)N1CCc2ccccc21)c1ccccc1NS(=O)(=O)c1ccc2c(c1)OCCO2.,O=C(OCC(=O)N1CCc2ccccc21)c1ccccc1NS(=O)(=O)c1ccc2c(c1)OCCO2,amine
174031,Please remove a halo from the molecule O=C(NCc1cccn1Cc1cccc(F)c1)Nc1ccccc1C(F)(F)F.,O=C(NCc1cccn1Cc1cccc(F)c1)Nc1ccccc1C(F)(F)F,halo
168019,Remove a halo from the molecule C[C@@H]1CCCC[C@@H]1[NH2+]CCn1ccc2c(Cl)cccc21.,C[C@@H]1CCCC[C@@H]1[NH2+]CCn1ccc2c(Cl)cccc21,halo
212025,Modify the molecule CC(C)(C)OC(=O)N1CCC(N)(C(N)=O)CC1 by removing a amide.,CC(C)(C)OC(=O)N1CCC(N)(C(N)=O)CC1,amide
53801,Please remove a hydroxyl from the molecule COc1ccc(COC[C@@H](O)Cn2cnc3ccccc3c2=O)cc1.,COc1ccc(COC[C@@H](O)Cn2cnc3ccccc3c2=O)cc1,hydroxyl
68499,Modify the molecule CCCNC(=O)[C@@H]1CCCN(C(=O)c2ccc(OC(C)(C)C)cc2)C1 by removing a amide.,CCCNC(=O)[C@@H]1CCCN(C(=O)c2ccc(OC(C)(C)C)cc2)C1,amide
214657,Modify the molecule O=C(Nc1ccc(F)c(F)c1)[C@H]1Nc2cc(F)ccc2S(=O)(=O)N1 by removing a halo.,O=C(Nc1ccc(F)c(F)c1)[C@H]1Nc2cc(F)ccc2S(=O)(=O)N1,halo
90812,Remove a hydroxyl from the molecule OCCc1ccc(OC[C@H]2CO2)cc1.,OCCc1ccc(OC[C@H]2CO2)cc1,hydroxyl
242892,Modify the molecule COC(=O)[C@H](C)NC(=O)[C@@H]1COc2ccc(F)cc2C1 by removing a amide.,COC(=O)[C@H](C)NC(=O)[C@@H]1COc2ccc(F)cc2C1,amide
221250,Modify the molecule OC[C@]1([NH2+]C2CC2)CC[C@@H](Sc2nc3ccccc3[nH]2)C1 by removing a hydroxyl.,OC[C@]1([NH2+]C2CC2)CC[C@@H](Sc2nc3ccccc3[nH]2)C1,hydroxyl
119127,Modify the molecule CCc1ccc([C@H]([NH2+][C@@H]2CCO[C@]3(CCSC3)C2)C(C)C)cc1 by removing a benzene_ring.,CCc1ccc([C@H]([NH2+][C@@H]2CCO[C@]3(CCSC3)C2)C(C)C)cc1,benzene_ring
108791,Remove a benzene_ring from the molecule CCOc1ccc(Nc2nc(-c3cccs3)c(CC(=O)[O-])s2)cc1.,CCOc1ccc(Nc2nc(-c3cccs3)c(CC(=O)[O-])s2)cc1,benzene_ring
133328,Please remove a amide from the molecule CNC(=O)c1cccc(N[C@H](C)C(=O)N2CCOCC2)c1.,CNC(=O)c1cccc(N[C@H](C)C(=O)N2CCOCC2)c1,amide
117326,Please remove a benzene_ring from the molecule Cc1ccccc1[C@H]1CC(c2cccc(NS(C)(=O)=O)c2)=NN1C(=O)C1CCCCC1.,Cc1ccccc1[C@H]1CC(c2cccc(NS(C)(=O)=O)c2)=NN1C(=O)C1CCCCC1,benzene_ring
108225,Modify the molecule C[C@H]1CCCC[C@@H]1NC(=O)COc1cc(O)c2c(c1)OC(C)(C)CC2=O by removing a hydroxyl.,C[C@H]1CCCC[C@@H]1NC(=O)COc1cc(O)c2c(c1)OC(C)(C)CC2=O,hydroxyl
33854,Remove a benzene_ring from the molecule COc1ccc(NC(=O)CN(C)C(=O)c2cccc(N3CCCC3=O)c2)cc1.,COc1ccc(NC(=O)CN(C)C(=O)c2cccc(N3CCCC3=O)c2)cc1,benzene_ring
8817,Please remove a benzene_ring from the molecule C[NH2+][C@H](c1ccc(OC)c(OC)c1)[C@H]1CCO[C@H]1C.,C[NH2+][C@H](c1ccc(OC)c(OC)c1)[C@H]1CCO[C@H]1C,benzene_ring
200665,Remove a benzene_ring from the molecule COc1ccc(C[C@H]([NH3+])c2ccc(OC)cc2)cc1.,COc1ccc(C[C@H]([NH3+])c2ccc(OC)cc2)cc1,benzene_ring
173106,Remove a benzene_ring from the molecule CO[C@H](CNC(=O)NC[C@@H]1CN2CCCC[C@@H]2CO1)c1ccccc1.,CO[C@H](CNC(=O)NC[C@@H]1CN2CCCC[C@@H]2CO1)c1ccccc1,benzene_ring
52707,Modify the molecule CC1=C(C(=O)CSc2nnc(C3=c4ccccc4=[NH+]C3)n2C2CC2)C[C@@H](C)N1C1CC1 by removing a amine.,CC1=C(C(=O)CSc2nnc(C3=c4ccccc4=[NH+]C3)n2C2CC2)C[C@@H](C)N1C1CC1,amine
90296,Remove a halo from the molecule CCN([C@@H](C)CS(=O)(=O)CC)S(=O)(=O)c1c[nH]c2nccc(Cl)c12.,CCN([C@@H](C)CS(=O)(=O)CC)S(=O)(=O)c1c[nH]c2nccc(Cl)c12,halo
50708,Remove a amide from the molecule CCS(=O)(=O)c1ccccc1C(=O)N1CCO[C@H](C)C1.,CCS(=O)(=O)c1ccccc1C(=O)N1CCO[C@H](C)C1,amide
106800,Modify the molecule CC(C)Cn1ncc(C(=O)N[C@@H]2CCCn3nc(C(C)C)nc32)c1C1CC1 by removing a amide.,CC(C)Cn1ncc(C(=O)N[C@@H]2CCCn3nc(C(C)C)nc32)c1C1CC1,amide
111359,Modify the molecule COc1cccc2sc(NC(=O)C[NH+]3CCC[C@@H]([C@@H](C)O)C3)nc12 by removing a amide.,COc1cccc2sc(NC(=O)C[NH+]3CCC[C@@H]([C@@H](C)O)C3)nc12,amide
42603,Remove a amide from the molecule CCc1ccc2oc(=O)cc(C[NH+]3CCC[C@H](N4CCCC4=O)C3)c2c1.,CCc1ccc2oc(=O)cc(C[NH+]3CCC[C@H](N4CCCC4=O)C3)c2c1,amide
197349,Please remove a benzene_ring from the molecule Cc1nn(Cc2ccccc2)c(C)c1C[NH+]1CCC[C@H](n2cccn2)C1.,Cc1nn(Cc2ccccc2)c(C)c1C[NH+]1CCC[C@H](n2cccn2)C1,benzene_ring
244693,Please remove a benzene_ring from the molecule CS(=O)(=O)C1=NN2C(=N)/C(=C\c3ccc(OCc4ccccc4)cc3)C(=O)N=C2S1.,CS(=O)(=O)C1=NN2C(=N)/C(=C\c3ccc(OCc4ccccc4)cc3)C(=O)N=C2S1,benzene_ring
242830,Modify the molecule CC(=O)Nc1nc(C(=O)N[C@H](C)c2ccccn2)cs1 by removing a amide.,CC(=O)Nc1nc(C(=O)N[C@H](C)c2ccccn2)cs1,amide
138302,Please remove a amine from the molecule Cc1cccc2c(CCNC(=O)NN[C@@]3(C)CCS(=O)(=O)C3)c[nH]c12.,Cc1cccc2c(CCNC(=O)NN[C@@]3(C)CCS(=O)(=O)C3)c[nH]c12,amine
18250,Remove a hydroxyl from the molecule CCOC(=O)[C@](C)(O)[C@@H](C)c1cccc2ccccc12.,CCOC(=O)[C@](C)(O)[C@@H](C)c1cccc2ccccc12,hydroxyl
115393,Modify the molecule COC(=O)c1ccc(CN(C)C(=O)c2oc3ccc(F)cc3c2C)cc1 by removing a benzene_ring.,COC(=O)c1ccc(CN(C)C(=O)c2oc3ccc(F)cc3c2C)cc1,benzene_ring
205387,Remove a benzene_ring from the molecule O=C(NCCc1cccc(Cl)c1)c1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)[nH]c3c2)cc1.,O=C(NCCc1cccc(Cl)c1)c1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)[nH]c3c2)cc1,benzene_ring
35191,Remove a amide from the molecule Cc1cc(C)c(O)c(NC(=O)[C@@H]([NH3+])Cc2ccccc2)c1.,Cc1cc(C)c(O)c(NC(=O)[C@@H]([NH3+])Cc2ccccc2)c1,amide
52703,Please remove a amine from the molecule c1ccc([C@H](NCCc2nnc3n2CCCCC3)C2CCCC2)cc1.,c1ccc([C@H](NCCc2nnc3n2CCCCC3)C2CCCC2)cc1,amine
134761,Modify the molecule COC(=O)[C@@H](C)[C@H](C)Sc1ccc(N)c(F)c1 by removing a benzene_ring.,COC(=O)[C@@H](C)[C@H](C)Sc1ccc(N)c(F)c1,benzene_ring
112955,Modify the molecule CCCC(=O)Nc1nn2c(-c3ccc(OC)cc3)nnc2s1 by removing a amide.,CCCC(=O)Nc1nn2c(-c3ccc(OC)cc3)nnc2s1,amide
198945,Please remove a hydroxyl from the molecule C[C@@H]1CCCC[NH+]1C[C@@H]1CCCN(C(=O)[C@H](O)c2ccccc2)C1.,C[C@@H]1CCCC[NH+]1C[C@@H]1CCCN(C(=O)[C@H](O)c2ccccc2)C1,hydroxyl
68991,Please remove a benzene_ring from the molecule CCN(C(=O)CN(CCO)c1ccccc1)C1CC1.,CCN(C(=O)CN(CCO)c1ccccc1)C1CC1,benzene_ring
195060,Please remove a amide from the molecule CCc1ccc([C@@H](C)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1.,CCc1ccc([C@@H](C)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1,amide
49678,Remove a benzene_ring from the molecule CCOC(=O)Cc1csc(NC(=O)c2ccc(C(F)(F)F)cc2)n1.,CCOC(=O)Cc1csc(NC(=O)c2ccc(C(F)(F)F)cc2)n1,benzene_ring
167880,Please remove a amide from the molecule CCN(CC)S(=O)(=O)c1ccc(C(=O)N2CC[C@@H](C)[C@H](O)C2)cc1.,CCN(CC)S(=O)(=O)c1ccc(C(=O)N2CC[C@@H](C)[C@H](O)C2)cc1,amide
92665,Remove a benzene_ring from the molecule Cc1cc([N-]S(=O)(=O)/C=C/c2ccccc2)no1.,Cc1cc([N-]S(=O)(=O)/C=C/c2ccccc2)no1,benzene_ring
147062,Please remove a halo from the molecule CN(Cc1cc(Br)cs1)C(=O)C[NH+](CCO)C1CC1.,CN(Cc1cc(Br)cs1)C(=O)C[NH+](CCO)C1CC1,halo
46045,Modify the molecule CNS(=O)(=O)c1ccc([C@H](C)NCCc2ccccn2)cc1 by removing a amine.,CNS(=O)(=O)c1ccc([C@H](C)NCCc2ccccn2)cc1,amine
131149,Modify the molecule C[C@H]1C[C@H]1c1ccc(/C=C/C(=O)Nc2ccccc2C(=O)NC2CC2)o1 by removing a amide.,C[C@H]1C[C@H]1c1ccc(/C=C/C(=O)Nc2ccccc2C(=O)NC2CC2)o1,amide
1005,Modify the molecule C[C@H]([NH2+][C@H](C)CC(=O)N(C)Cc1cccc(Cl)c1)C1CCC1 by removing a benzene_ring.,C[C@H]([NH2+][C@H](C)CC(=O)N(C)Cc1cccc(Cl)c1)C1CCC1,benzene_ring
47819,Remove a amine from the molecule O=C(Nc1ccc2cn[nH]c2c1)c1csc(Nc2ccccn2)n1.,O=C(Nc1ccc2cn[nH]c2c1)c1csc(Nc2ccccn2)n1,amine
219660,Remove a amine from the molecule C=CCNc1ccc(S(=O)(=O)N2CCC(C)CC2)cc1[N+](=O)[O-].,C=CCNc1ccc(S(=O)(=O)N2CCC(C)CC2)cc1[N+](=O)[O-],amine
213773,Please remove a nitrile from the molecule Cn1nc(C(F)(F)F)c(C#N)c1N1CC[NH+](C(c2ccccc2)c2ccccc2)CC1.,Cn1nc(C(F)(F)F)c(C#N)c1N1CC[NH+](C(c2ccccc2)c2ccccc2)CC1,nitrile
10698,Please remove a benzene_ring from the molecule C[C@@H](Cc1cccs1)NC(=O)C(=O)Nc1cc(F)cc(F)c1.,C[C@@H](Cc1cccs1)NC(=O)C(=O)Nc1cc(F)cc(F)c1,benzene_ring
107117,Remove a amine from the molecule CCNc1ncnc(Nc2cccc(Br)c2)c1[N+](=O)[O-].,CCNc1ncnc(Nc2cccc(Br)c2)c1[N+](=O)[O-],amine
171337,Remove a amide from the molecule COc1ccc(OC)c2sc(N(Cc3cccnc3)C(=O)c3c[nH]c4ccccc34)nc12.,COc1ccc(OC)c2sc(N(Cc3cccnc3)C(=O)c3c[nH]c4ccccc34)nc12,amide
26234,Modify the molecule O=C(Cc1ccc(F)c(F)c1)NC1CC1 by removing a benzene_ring.,O=C(Cc1ccc(F)c(F)c1)NC1CC1,benzene_ring
124374,Remove a amide from the molecule CCC(=O)Nc1ccc(N2CCN(Cc3nc4ccccc4n3C)CC2)c(Cl)c1.,CCC(=O)Nc1ccc(N2CCN(Cc3nc4ccccc4n3C)CC2)c(Cl)c1,amide
59134,Modify the molecule CN(CCC#N)C(=O)CN1CC[NH+](C[C@H](O)C(C)(C)C)CC1 by removing a amide.,CN(CCC#N)C(=O)CN1CC[NH+](C[C@H](O)C(C)(C)C)CC1,amide
189835,Modify the molecule Fc1cc(NCc2nnnn2C2CC2)ccc1Cl by removing a halo.,Fc1cc(NCc2nnnn2C2CC2)ccc1Cl,halo
154488,Modify the molecule CCCn1c([O-])c(C(=O)NNC(=O)c2ccccc2[N+](=O)[O-])c(=O)c2ccccc21 by removing a amide.,CCCn1c([O-])c(C(=O)NNC(=O)c2ccccc2[N+](=O)[O-])c(=O)c2ccccc21,amide
190059,Remove a benzene_ring from the molecule COc1ccc(C[NH2+]CCNc2ccc(F)c(Cl)c2)cc1.,COc1ccc(C[NH2+]CCNc2ccc(F)c(Cl)c2)cc1,benzene_ring
235835,Modify the molecule COc1ccc(Br)cc1[C@H]1C(C#N)=C(N)Oc2cc(C)n(O)c(=O)c21 by removing a benzene_ring.,COc1ccc(Br)cc1[C@H]1C(C#N)=C(N)Oc2cc(C)n(O)c(=O)c21,benzene_ring
231442,Please remove a amide from the molecule COCc1cccc(NC(=O)N2CCN(C(=O)c3ccco3)CC2)c1.,COCc1cccc(NC(=O)N2CCN(C(=O)c3ccco3)CC2)c1,amide
199901,Remove a benzene_ring from the molecule COc1cc(C[NH2+]C[C@@H]2CN3CCCC[C@@H]3CO2)c(SC)cc1OC.,COc1cc(C[NH2+]C[C@@H]2CN3CCCC[C@@H]3CO2)c(SC)cc1OC,benzene_ring
171207,Remove a amide from the molecule O=C(COc1ccc2ccccc2c1)Nc1cccc(C(=O)N2CCCCC2)c1.,O=C(COc1ccc2ccccc2c1)Nc1cccc(C(=O)N2CCCCC2)c1,amide
170640,Modify the molecule COC(=O)[C@@H](C)N1C(=O)S/C(=C/c2ccc(-c3ccccc3C#N)o2)C1=O by removing a nitrile.,COC(=O)[C@@H](C)N1C(=O)S/C(=C/c2ccc(-c3ccccc3C#N)o2)C1=O,nitrile
241050,Please remove a amide from the molecule COC(=O)c1cccc2c1CCCN2C(=O)CCCn1cnc2c(C)cccc2c1=O.,COC(=O)c1cccc2c1CCCN2C(=O)CCCn1cnc2c(C)cccc2c1=O,amide
39027,Remove a amide from the molecule O=C(Nc1ccn(Cc2ccccc2)n1)c1cc(Cl)ccc1Cl.,O=C(Nc1ccn(Cc2ccccc2)n1)c1cc(Cl)ccc1Cl,amide
124415,Please remove a benzene_ring from the molecule COc1ccc(C(=O)c2coc3ccc(O)c(C[NH+](C)C)c23)cc1.,COc1ccc(C(=O)c2coc3ccc(O)c(C[NH+](C)C)c23)cc1,benzene_ring
10906,Modify the molecule O=C(Nc1ccc(F)c(F)c1)[C@H]1CCCN(c2ccc(-n3ccnc3)nn2)C1 by removing a benzene_ring.,O=C(Nc1ccc(F)c(F)c1)[C@H]1CCCN(c2ccc(-n3ccnc3)nn2)C1,benzene_ring
99046,Please remove a hydroxyl from the molecule O=c1c2ccccc2oc2cc3c(c(O)c12)CCCC3.,O=c1c2ccccc2oc2cc3c(c(O)c12)CCCC3,hydroxyl
233185,Modify the molecule NC1=C(Br)[C@H](C(F)(F)F)N=N1 by removing a halo.,NC1=C(Br)[C@H](C(F)(F)F)N=N1,halo
141008,Please remove a benzene_ring from the molecule COc1ccccc1C[C@H](C)N(C)C(=O)NC[C@H]1CN2CCCC[C@@H]2CO1.,COc1ccccc1C[C@H](C)N(C)C(=O)NC[C@H]1CN2CCCC[C@@H]2CO1,benzene_ring
126383,Modify the molecule Nc1ccc(F)c(NC(=O)CC[NH+]2CCCCCCC2)c1 by removing a benzene_ring.,Nc1ccc(F)c(NC(=O)CC[NH+]2CCCCCCC2)c1,benzene_ring
229003,Please remove a nitrile from the molecule N#C[C@H]1CN(C(=O)c2c(O)cccc2O)CCN1Cc1ccccc1.,N#C[C@H]1CN(C(=O)c2c(O)cccc2O)CCN1Cc1ccccc1,nitrile
39602,Modify the molecule CCOc1ccc(C(=O)N(Cc2ccco2)c2nc3c(F)cccc3s2)cc1 by removing a benzene_ring.,CCOc1ccc(C(=O)N(Cc2ccco2)c2nc3c(F)cccc3s2)cc1,benzene_ring
242904,Remove a halo from the molecule Cc1sc(Br)cc1S(=O)(=O)N1CCO[C@@H](C#N)C1.,Cc1sc(Br)cc1S(=O)(=O)N1CCO[C@@H](C#N)C1,halo
155383,Please remove a nitrile from the molecule N#Cc1cccc(CNC(=O)N(Cc2cccnc2)C[C@H]2CCCO2)c1.,N#Cc1cccc(CNC(=O)N(Cc2cccnc2)C[C@H]2CCCO2)c1,nitrile
199243,Remove a halo from the molecule N#Cc1nc(-c2ccccc2)c(-c2ccccc2)nc1Cl.,N#Cc1nc(-c2ccccc2)c(-c2ccccc2)nc1Cl,halo
143897,Modify the molecule Cc1occc1C(=O)[C@@H](C#N)c1nc(-c2ccc(C#N)cc2)cs1 by removing a benzene_ring.,Cc1occc1C(=O)[C@@H](C#N)c1nc(-c2ccc(C#N)cc2)cs1,benzene_ring
143127,Modify the molecule O=C(CN1C(=O)/C(=C/c2cccs2)SC1=S)Nc1cc(C(=O)[O-])ccc1C(=O)[O-] by removing a benzene_ring.,O=C(CN1C(=O)/C(=C/c2cccs2)SC1=S)Nc1cc(C(=O)[O-])ccc1C(=O)[O-],benzene_ring
110308,Modify the molecule CC(C)CC1=C[C@H]([C@H]2NN[C@H]3SC(c4ccc5c(c4)OCCO5)=NN23)N=N1 by removing a amine.,CC(C)CC1=C[C@H]([C@H]2NN[C@H]3SC(c4ccc5c(c4)OCCO5)=NN23)N=N1,amine
74129,Remove a benzene_ring from the molecule CCC[C@H]([NH2+]Cc1ccc(C)cc1)c1ccccc1.,CCC[C@H]([NH2+]Cc1ccc(C)cc1)c1ccccc1,benzene_ring
29942,Remove a amine from the molecule Cc1nn(-c2nc3c(Cl)c(Cl)ccc3s2)c(C)c1C(=O)NN.,Cc1nn(-c2nc3c(Cl)c(Cl)ccc3s2)c(C)c1C(=O)NN,amine
19020,Modify the molecule COc1cc(F)c([N+](=O)[O-])c(NCCCc2nnc3n2CCCCC3)c1 by removing a halo.,COc1cc(F)c([N+](=O)[O-])c(NCCCc2nnc3n2CCCCC3)c1,halo
217105,Modify the molecule CCC[C@@H]1C[C@@H]1NC(=O)c1oc2ccccc2c1C[NH+](C)C by removing a amide.,CCC[C@@H]1C[C@@H]1NC(=O)c1oc2ccccc2c1C[NH+](C)C,amide
56003,Modify the molecule Cc1nn(C)c(C[C@H]([NH3+])[C@@]2(C)CCCO2)c1Cl by removing a halo.,Cc1nn(C)c(C[C@H]([NH3+])[C@@]2(C)CCCO2)c1Cl,halo
54221,Remove a benzene_ring from the molecule COc1cccc(F)c1[C@H](C)NC(=O)NCC[NH+]1CCC(OC)CC1.,COc1cccc(F)c1[C@H](C)NC(=O)NCC[NH+]1CCC(OC)CC1,benzene_ring
152905,Remove a benzene_ring from the molecule COc1cccc(OC)c1OC(=O)Cn1c(=O)sc2ccccc21.,COc1cccc(OC)c1OC(=O)Cn1c(=O)sc2ccccc21,benzene_ring
53369,Please remove a amide from the molecule CN(CCc1ccccc1)C(=O)c1occc1Br.,CN(CCc1ccccc1)C(=O)c1occc1Br,amide
188798,Please remove a halo from the molecule CCOc1ccccc1CN(C[C@H]1CCCO1)C(=O)Nc1cccc(Cl)c1.,CCOc1ccccc1CN(C[C@H]1CCCO1)C(=O)Nc1cccc(Cl)c1,halo
152906,Modify the molecule CCc1nc2c(s1)[C@@H](N(C)C(C)=O)CCC2 by removing a amide.,CCc1nc2c(s1)[C@@H](N(C)C(C)=O)CCC2,amide
204974,Remove a halo from the molecule C[C@@H]([NH2+]Cc1csc(C2CC2)n1)c1ccc(Cl)s1.,C[C@@H]([NH2+]Cc1csc(C2CC2)n1)c1ccc(Cl)s1,halo
228105,Modify the molecule CC(C)CNC(=O)CNC(=O)N1Cc2ccccc2N(C)C[C@@H]1C by removing a amide.,CC(C)CNC(=O)CNC(=O)N1Cc2ccccc2N(C)C[C@@H]1C,amide
78635,Remove a amide from the molecule CCSc1nnc(NC(=O)/C=C/Sc2ccccc2)s1.,CCSc1nnc(NC(=O)/C=C/Sc2ccccc2)s1,amide
126133,Please remove a nitrile from the molecule CCSCCOC(=O)/C=C/c1cccc(C#N)c1.,CCSCCOC(=O)/C=C/c1cccc(C#N)c1,nitrile
44212,Please remove a amide from the molecule C[C@H]1CCC[NH+]([C@@H](C)CNC(=O)C(=O)Nc2ccc3[nH]ncc3c2)C1.,C[C@H]1CCC[NH+]([C@@H](C)CNC(=O)C(=O)Nc2ccc3[nH]ncc3c2)C1,amide
226965,Remove a amide from the molecule CC1=NN[C@H](SCC(=O)Nc2nc(C)cs2)N1C.,CC1=NN[C@H](SCC(=O)Nc2nc(C)cs2)N1C,amide
228754,Remove a benzene_ring from the molecule N#Cc1ccc(OCc2ccc(C(=O)N=c3[nH]c4ccccc4[nH]3)o2)cc1.,N#Cc1ccc(OCc2ccc(C(=O)N=c3[nH]c4ccccc4[nH]3)o2)cc1,benzene_ring
80910,Please remove a halo from the molecule CC(C)/C=C/C(=O)N1CCc2nnc(CNC(=O)c3cccc(F)c3)n2CC1.,CC(C)/C=C/C(=O)N1CCc2nnc(CNC(=O)c3cccc(F)c3)n2CC1,halo
149924,Modify the molecule Cc1cc(C(=O)NCCC/C(N)=N/O)sc1Br by removing a amine.,Cc1cc(C(=O)NCCC/C(N)=N/O)sc1Br,amine
133900,Please remove a hydroxyl from the molecule Cc1cc(C(=O)N(C)[C@@H](C)C(C)(C)C)sc1C#CCCO.,Cc1cc(C(=O)N(C)[C@@H](C)C(C)(C)C)sc1C#CCCO,hydroxyl
71703,Please remove a benzene_ring from the molecule CC(C)[NH2+][C@@H]1CC(=O)N(Cc2cccc(F)c2)C1.,CC(C)[NH2+][C@@H]1CC(=O)N(Cc2cccc(F)c2)C1,benzene_ring
20191,Please remove a nitrile from the molecule CC(C)c1nc([C@H]2CCCN2c2ncc(C#N)cc2Cl)no1.,CC(C)c1nc([C@H]2CCCN2c2ncc(C#N)cc2Cl)no1,nitrile
37419,Remove a amide from the molecule CC(C)(C)NC(=O)[C@H]1COc2ccccc2O1.,CC(C)(C)NC(=O)[C@H]1COc2ccccc2O1,amide
200988,Remove a benzene_ring from the molecule Cc1cc([C@H]2[C@@H](C[NH2+]C3CC3)CCCN2C)ccc1Br.,Cc1cc([C@H]2[C@@H](C[NH2+]C3CC3)CCCN2C)ccc1Br,benzene_ring
158917,Please remove a benzene_ring from the molecule COc1c(C)cc(S(=O)(=O)NCC[C@H](O)C2CC2)cc1C.,COc1c(C)cc(S(=O)(=O)NCC[C@H](O)C2CC2)cc1C,benzene_ring
152685,Modify the molecule O=C1OCCN1c1cccc(NS(=O)(=O)c2cccc(C(F)(F)F)c2)c1 by removing a halo.,O=C1OCCN1c1cccc(NS(=O)(=O)c2cccc(C(F)(F)F)c2)c1,halo
98821,Remove a amine from the molecule CC/[NH+]=C(/NCc1nnc2n1CCCCC2)N[C@@H]1C[C@@H]1C.,CC/[NH+]=C(/NCc1nnc2n1CCCCC2)N[C@@H]1C[C@@H]1C,amine
172186,Remove a halo from the molecule Cc1cc(F)c([C@@H](C)CC[NH3+])cc1F.,Cc1cc(F)c([C@@H](C)CC[NH3+])cc1F,halo
30686,Remove a halo from the molecule Cc1ccc(NC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)cc1Br.,Cc1ccc(NC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)cc1Br,halo
20514,Remove a amide from the molecule COCC(=O)N1CCCN(Cc2cnc(-c3ccccn3)nc2)CC1.,COCC(=O)N1CCCN(Cc2cnc(-c3ccccn3)nc2)CC1,amide
151517,Please remove a amide from the molecule CN1C[C@@H](NC(=O)NCc2ccnc(OC3CCC3)c2)CCC1=O.,CN1C[C@@H](NC(=O)NCc2ccnc(OC3CCC3)c2)CCC1=O,amide
34842,Please remove a amide from the molecule CC(C)[C@@H](NC(=O)C(=O)Nc1cccc(-c2ncon2)c1)c1ccccn1.,CC(C)[C@@H](NC(=O)C(=O)Nc1cccc(-c2ncon2)c1)c1ccccn1,amide
108153,Modify the molecule O=C(NNC(=S)[S-])c1cnccn1 by removing a amine.,O=C(NNC(=S)[S-])c1cnccn1,amine
25001,Modify the molecule O=c1c(-c2nccs2)nc2ccc(NCc3c(F)cccc3F)nc2n1Cc1ccncc1 by removing a halo.,O=c1c(-c2nccs2)nc2ccc(NCc3c(F)cccc3F)nc2n1Cc1ccncc1,halo
220339,Remove a benzene_ring from the molecule CCc1ccc(C[NH2+]Cc2ccccc2)cc1.,CCc1ccc(C[NH2+]Cc2ccccc2)cc1,benzene_ring
206890,Modify the molecule C[C@@H](SCc1ccccc1)C(=O)NC[C@@H](C)N1CC[NH+](C)CC1 by removing a benzene_ring.,C[C@@H](SCc1ccccc1)C(=O)NC[C@@H](C)N1CC[NH+](C)CC1,benzene_ring
66611,Please remove a halo from the molecule CSCc1cc(F)ccc1CNC(=O)c1c(F)cccc1Cl.,CSCc1cc(F)ccc1CNC(=O)c1c(F)cccc1Cl,halo
245427,Modify the molecule C[C@H]1C[C@@H]1NC(=O)c1c[nH]nc1-c1cccc(OC(F)F)c1 by removing a amide.,C[C@H]1C[C@@H]1NC(=O)c1c[nH]nc1-c1cccc(OC(F)F)c1,amide
244919,Please remove a amine from the molecule COc1ccc(OC)c(NS(=O)(=O)c2ccc(CC(C)C)cc2)c1.,COc1ccc(OC)c(NS(=O)(=O)c2ccc(CC(C)C)cc2)c1,amine
123382,Modify the molecule Cc1ccc(NC(=O)[C@H](C)Cc2cccc(C(F)(F)F)c2)cc1C(N)=O by removing a benzene_ring.,Cc1ccc(NC(=O)[C@H](C)Cc2cccc(C(F)(F)F)c2)cc1C(N)=O,benzene_ring
140818,Please remove a amide from the molecule COc1cc(NC(=O)c2cc(C)cc(C)c2)c(OC)cc1NC(=O)c1ccccc1.,COc1cc(NC(=O)c2cc(C)cc(C)c2)c(OC)cc1NC(=O)c1ccccc1,amide
192378,Please remove a halo from the molecule Cc1cccc(-n2c(C)cc(C(=O)C(=O)Nc3ccccc3F)c2C)c1C.,Cc1cccc(-n2c(C)cc(C(=O)C(=O)Nc3ccccc3F)c2C)c1C,halo
66648,Modify the molecule CC(=O)Nc1nc(SCC(=O)N2C[C@H](C)O[C@H](C)C2)[nH]c(=O)c1NC(=O)c1ccccc1 by removing a amide.,CC(=O)Nc1nc(SCC(=O)N2C[C@H](C)O[C@H](C)C2)[nH]c(=O)c1NC(=O)c1ccccc1,amide
61847,Modify the molecule Cc1cncc(C(=O)N2CCCc3cc(C)ccc32)c1 by removing a amide.,Cc1cncc(C(=O)N2CCCc3cc(C)ccc32)c1,amide
160161,Modify the molecule O=C(C1CCN([C@H]2CCS(=O)(=O)C2)CC1)N1CCN(Cc2ccc3c(c2)CCO3)CC1 by removing a amide.,O=C(C1CCN([C@H]2CCS(=O)(=O)C2)CC1)N1CCN(Cc2ccc3c(c2)CCO3)CC1,amide
115968,Remove a benzene_ring from the molecule Cn1c(SC(c2ccccc2)c2ccccc2)nnc1[C@H]1COc2ccccc2O1.,Cn1c(SC(c2ccccc2)c2ccccc2)nnc1[C@H]1COc2ccccc2O1,benzene_ring
202906,Please remove a benzene_ring from the molecule CC(=O)Nc1cccc([C@H](C)NC(=O)CCc2ncc(-c3ccc(C)c(C)c3)o2)c1.,CC(=O)Nc1cccc([C@H](C)NC(=O)CCc2ncc(-c3ccc(C)c(C)c3)o2)c1,benzene_ring
185711,Please remove a halo from the molecule CC(C)(C)OC(=O)c1nc([O-])n(-c2ccc(Br)cc2)n1.,CC(C)(C)OC(=O)c1nc([O-])n(-c2ccc(Br)cc2)n1,halo
125072,Remove a amide from the molecule CC(C)(C#N)CCCNc1ccccc1C(=O)N1CCC[C@@H]1CO.,CC(C)(C#N)CCCNc1ccccc1C(=O)N1CCC[C@@H]1CO,amide
104792,Remove a benzene_ring from the molecule N#Cc1csc(C(=O)NCc2cccc(NC(=O)C3CCCC3)c2)c1.,N#Cc1csc(C(=O)NCc2cccc(NC(=O)C3CCCC3)c2)c1,benzene_ring
97535,Please remove a amide from the molecule Cn1nc(C(F)(F)F)c2cc(C(=O)N3C[C@@H]4CC[C@H](C3)[NH+](C)C4)sc21.,Cn1nc(C(F)(F)F)c2cc(C(=O)N3C[C@@H]4CC[C@H](C3)[NH+](C)C4)sc21,amide
170009,Remove a benzene_ring from the molecule COc1ccc(F)c(N2C(=O)CNC(=O)[C@@H]2C(C)C)c1.,COc1ccc(F)c(N2C(=O)CNC(=O)[C@@H]2C(C)C)c1,benzene_ring
108540,Modify the molecule CNS(=O)(=O)c1ccc(N(C)Cc2ccc(Br)cc2)c([N+](=O)[O-])c1 by removing a halo.,CNS(=O)(=O)c1ccc(N(C)Cc2ccc(Br)cc2)c([N+](=O)[O-])c1,halo
175244,Modify the molecule CC(C)OCCCNC(=O)C1CCN(C(=O)[C@@H]2CCO[C@H]2C)CC1 by removing a amide.,CC(C)OCCCNC(=O)C1CCN(C(=O)[C@@H]2CCO[C@H]2C)CC1,amide
188811,Modify the molecule CC(C)N(C)C(=O)CCc1nnc(-c2ccsc2)o1 by removing a amide.,CC(C)N(C)C(=O)CCc1nnc(-c2ccsc2)o1,amide
237720,Modify the molecule O=C(NCc1ccncc1)N(Cc1ccc(O)cc1)CC1CC1 by removing a hydroxyl.,O=C(NCc1ccncc1)N(Cc1ccc(O)cc1)CC1CC1,hydroxyl
14669,Remove a amine from the molecule COc1ccccc1CNc1nc2ccc(Cl)cc2nc1-n1nc(C)cc1C.,COc1ccccc1CNc1nc2ccc(Cl)cc2nc1-n1nc(C)cc1C,amine
238505,Remove a benzene_ring from the molecule COc1ccc(C2=N[C@H](c3ccc(F)c(Br)c3)N[C@H](c3ccccc3O)C2)cc1.,COc1ccc(C2=N[C@H](c3ccc(F)c(Br)c3)N[C@H](c3ccccc3O)C2)cc1,benzene_ring
95571,Modify the molecule Cc1cc(C)c(C(=O)NCCNc2ccccc2)c(=O)[nH]1 by removing a amine.,Cc1cc(C)c(C(=O)NCCNc2ccccc2)c(=O)[nH]1,amine
179431,Modify the molecule Cc1cc(CC(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)no1 by removing a benzene_ring.,Cc1cc(CC(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)no1,benzene_ring
181747,Remove a benzene_ring from the molecule CCOc1c(F)cccc1C(=O)Nc1ccc(-n2ccnc2)cc1.,CCOc1c(F)cccc1C(=O)Nc1ccc(-n2ccnc2)cc1,benzene_ring
243505,Modify the molecule Nc1nc(C(=O)Nc2ccccc2)cs1 by removing a amine.,Nc1nc(C(=O)Nc2ccccc2)cs1,amine
226142,Modify the molecule CC(C)(C)[C@](O)(Cn1cncn1)[C@@H]1O[C@@H]1c1ccc(Cl)cc1 by removing a hydroxyl.,CC(C)(C)[C@](O)(Cn1cncn1)[C@@H]1O[C@@H]1c1ccc(Cl)cc1,hydroxyl
83388,Modify the molecule O=C(Nc1ccc2[nH]ccc2c1)C(=O)N[C@@H](c1nccs1)C1CC1 by removing a amide.,O=C(Nc1ccc2[nH]ccc2c1)C(=O)N[C@@H](c1nccs1)C1CC1,amide
245383,Remove a benzene_ring from the molecule C[C@H](C[NH+](C)CC(C)(C)S(C)(=O)=O)c1cccc(Br)c1.,C[C@H](C[NH+](C)CC(C)(C)S(C)(=O)=O)c1cccc(Br)c1,benzene_ring
32010,Modify the molecule Cc1ccc(N2C[C@H](C(=O)N3CC[C@H](c4ccccc4)C3)CC2=O)cc1 by removing a benzene_ring.,Cc1ccc(N2C[C@H](C(=O)N3CC[C@H](c4ccccc4)C3)CC2=O)cc1,benzene_ring
55338,Remove a amide from the molecule CNC(=O)C[NH+](C)Cc1cc(Cl)cc(Cl)c1.,CNC(=O)C[NH+](C)Cc1cc(Cl)cc(Cl)c1,amide
209866,Please remove a amide from the molecule Cc1ccc(C(=O)N(C)Cc2nnn[n-]2)cc1.,Cc1ccc(C(=O)N(C)Cc2nnn[n-]2)cc1,amide
75739,Modify the molecule COc1ccc(CNC(=O)N[C@@H]2C=C[C@H](CO)C2)c(OC2CCCC2)c1 by removing a benzene_ring.,COc1ccc(CNC(=O)N[C@@H]2C=C[C@H](CO)C2)c(OC2CCCC2)c1,benzene_ring
199713,Remove a halo from the molecule CN(Cc1ccccc1C(F)(F)F)C(=O)NCCc1cccc(F)c1.,CN(Cc1ccccc1C(F)(F)F)C(=O)NCCc1cccc(F)c1,halo
27706,Please remove a halo from the molecule C[C@H]1C[C@@H](N2CCN(c3cccc(Cl)c3)CC2)C(=O)O1.,C[C@H]1C[C@@H](N2CCN(c3cccc(Cl)c3)CC2)C(=O)O1,halo
75672,Remove a benzene_ring from the molecule C[C@@H]1CCCC[C@@H]1[NH+](C)Cc1cc(F)cc(C#CC[NH3+])c1.,C[C@@H]1CCCC[C@@H]1[NH+](C)Cc1cc(F)cc(C#CC[NH3+])c1,benzene_ring
172801,Remove a amide from the molecule Cc1ccc(N2CCn3c2nnc(C(=O)NCc2cccs2)c3=O)cc1.,Cc1ccc(N2CCn3c2nnc(C(=O)NCc2cccs2)c3=O)cc1,amide
83727,Please remove a amide from the molecule COc1ccc(Cl)cc1NC(=O)[C@@H]1CN(C(C)=O)c2ccccc2O1.,COc1ccc(Cl)cc1NC(=O)[C@@H]1CN(C(C)=O)c2ccccc2O1,amide
203696,Modify the molecule CCn1nnnc1-c1ccc(OC)c(S(=O)(=O)Nc2ccc(C)c(C)c2)c1 by removing a amine.,CCn1nnnc1-c1ccc(OC)c(S(=O)(=O)Nc2ccc(C)c(C)c2)c1,amine
80906,Please remove a amide from the molecule Cc1noc(C)c1S(=O)(=O)NCCNC(=O)c1cccn1C.,Cc1noc(C)c1S(=O)(=O)NCCNC(=O)c1cccn1C,amide
810,Modify the molecule O=C(Nc1ccccc1)NC1CCN(C(=O)[C@H]2CCCC[C@H]2C(F)(F)F)CC1 by removing a amide.,O=C(Nc1ccccc1)NC1CCN(C(=O)[C@H]2CCCC[C@H]2C(F)(F)F)CC1,amide
137152,Please remove a hydroxyl from the molecule C[C@H]1CCN(C(=O)COc2ccccc2Br)C[C@H]1O.,C[C@H]1CCN(C(=O)COc2ccccc2Br)C[C@H]1O,hydroxyl
143959,Please remove a benzene_ring from the molecule CCOc1cccnc1C(=O)O[C@@H](C)c1cccc(OC)c1.,CCOc1cccnc1C(=O)O[C@@H](C)c1cccc(OC)c1,benzene_ring
170455,Modify the molecule C[C@@H](N[C@H](c1cccnc1)c1ccc(F)c(F)c1)c1cnn(C)c1 by removing a benzene_ring.,C[C@@H](N[C@H](c1cccnc1)c1ccc(F)c(F)c1)c1cnn(C)c1,benzene_ring
239448,Remove a benzene_ring from the molecule COC(=O)CNC(=O)CCN1CCO[C@@H](c2ccccc2Br)C1.,COC(=O)CNC(=O)CCN1CCO[C@@H](c2ccccc2Br)C1,benzene_ring
74853,Remove a benzene_ring from the molecule Cc1cc(N(C)C)cc(C)c1NC(=O)CCn1cnc2ccccc21.,Cc1cc(N(C)C)cc(C)c1NC(=O)CCn1cnc2ccccc21,benzene_ring
4182,Remove a amide from the molecule COCCNC(=O)[C@@H](C)CS(=O)(=O)c1ccc(Br)cc1.,COCCNC(=O)[C@@H](C)CS(=O)(=O)c1ccc(Br)cc1,amide
36912,Remove a benzene_ring from the molecule COc1ccc(NC(=O)Cn2cnc(C3CCC3)cc2=O)c([N+](=O)[O-])c1.,COc1ccc(NC(=O)Cn2cnc(C3CCC3)cc2=O)c([N+](=O)[O-])c1,benzene_ring
115180,Please remove a amide from the molecule C[C@@H](c1nc2ccccc2s1)N(C)C(=O)c1cccc(Nc2ncccn2)c1.,C[C@@H](c1nc2ccccc2s1)N(C)C(=O)c1cccc(Nc2ncccn2)c1,amide
36740,Please remove a benzene_ring from the molecule N#C[C@@H]1CCC[C@H]1Sc1ccccc1Br.,N#C[C@@H]1CCC[C@H]1Sc1ccccc1Br,benzene_ring
183095,Remove a amide from the molecule C[C@@H](c1cccnc1)N(C)C(=O)Nc1ccn(CCCC(=O)N(C)C)n1.,C[C@@H](c1cccnc1)N(C)C(=O)Nc1ccn(CCCC(=O)N(C)C)n1,amide
4357,Please remove a amide from the molecule NC(=O)c1cc([N+](=O)[O-])ccc1O[C@H]1CCC[C@@H]([NH3+])C1.,NC(=O)c1cc([N+](=O)[O-])ccc1O[C@H]1CCC[C@@H]([NH3+])C1,amide
249133,Modify the molecule COc1ccc(/C=C2\CCCc3c2nc2ccccc2c3C(=O)OCC(N)=O)cc1 by removing a amide.,COc1ccc(/C=C2\CCCc3c2nc2ccccc2c3C(=O)OCC(N)=O)cc1,amide
60971,Modify the molecule CCO[C@H]1C[C@@H](NC(=O)C(=O)Nc2cc(C(C)C)on2)C12CCCC2 by removing a amide.,CCO[C@H]1C[C@@H](NC(=O)C(=O)Nc2cc(C(C)C)on2)C12CCCC2,amide
233071,Modify the molecule C[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)Nc1ccc(N2CC[NH+](C)CC2)nc1 by removing a halo.,C[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)Nc1ccc(N2CC[NH+](C)CC2)nc1,halo
200537,Modify the molecule O=C(Nc1cc(F)ccc1F)[C@H]1CCS(=O)(=O)C1 by removing a halo.,O=C(Nc1cc(F)ccc1F)[C@H]1CCS(=O)(=O)C1,halo
243683,Remove a amide from the molecule CO[C@@H](C)C(=O)Nc1cccc(NS(=O)(=O)c2cc(C)ccc2F)c1.,CO[C@@H](C)C(=O)Nc1cccc(NS(=O)(=O)c2cc(C)ccc2F)c1,amide
145495,Modify the molecule C[NH2+]C[C@H](C)C(=O)NC[C@H]1CCC(=O)N1 by removing a amide.,C[NH2+]C[C@H](C)C(=O)NC[C@H]1CCC(=O)N1,amide
209480,Please remove a amine from the molecule CN/C(=[NH+]\C)SCC(=O)N(C)Cc1ccc(Cl)s1.,CN/C(=[NH+]\C)SCC(=O)N(C)Cc1ccc(Cl)s1,amine
229002,Remove a amide from the molecule C[C@H]1C[C@@H]1c1ccc(CN(C)C(=O)c2ccc(NC(N)=O)cc2)o1.,C[C@H]1C[C@@H]1c1ccc(CN(C)C(=O)c2ccc(NC(N)=O)cc2)o1,amide
38809,Modify the molecule O=C([O-])[C@H]1CCCCN1C(=O)c1nc(C2CC2)n[nH]1 by removing a amide.,O=C([O-])[C@H]1CCCCN1C(=O)c1nc(C2CC2)n[nH]1,amide
141594,Modify the molecule CCN(C(=O)c1cccc(C(F)(F)F)c1F)C1C[NH2+]C1 by removing a amide.,CCN(C(=O)c1cccc(C(F)(F)F)c1F)C1C[NH2+]C1,amide
55697,Please remove a amide from the molecule COc1ccc(-c2ccc(=O)n([C@@H](C)C(=O)Nc3ccc(OC)c(OC)c3)n2)cc1.,COc1ccc(-c2ccc(=O)n([C@@H](C)C(=O)Nc3ccc(OC)c(OC)c3)n2)cc1,amide
194457,Remove a hydroxyl from the molecule CC[C@@H](CO)N1CC[NH+](C2CCC(C(C)C)CC2)CC1.,CC[C@@H](CO)N1CC[NH+](C2CCC(C(C)C)CC2)CC1,hydroxyl
232000,Modify the molecule Cc1cc(-c2c(-c3ccccc3)ncn2CCCO)cc(C)c1O by removing a benzene_ring.,Cc1cc(-c2c(-c3ccccc3)ncn2CCCO)cc(C)c1O,benzene_ring
120031,Remove a amide from the molecule CC(C)c1n[nH]c([C@H]2CN(C(=O)c3ccc(=O)n(C)n3)CCO2)n1.,CC(C)c1n[nH]c([C@H]2CN(C(=O)c3ccc(=O)n(C)n3)CCO2)n1,amide
17279,Modify the molecule Cc1cc(N2CC[C@@H](N[C@H](C)c3cccnc3Cl)C2=O)n(C)n1 by removing a amine.,Cc1cc(N2CC[C@@H](N[C@H](C)c3cccnc3Cl)C2=O)n(C)n1,amine
149249,Please remove a halo from the molecule COc1ccc(CC(=O)NCc2ccccc2F)cc1OC.,COc1ccc(CC(=O)NCc2ccccc2F)cc1OC,halo
148976,Modify the molecule CCOC(=O)c1c(NC(=O)CSc2n[nH]c(N)n2)sc2c1CC[C@H](C)C2 by removing a amide.,CCOC(=O)c1c(NC(=O)CSc2n[nH]c(N)n2)sc2c1CC[C@H](C)C2,amide
208090,Please remove a benzene_ring from the molecule O=c1c(Cc2ccc(Cl)cc2)c([O-])ccn1Cc1ccccc1.,O=c1c(Cc2ccc(Cl)cc2)c([O-])ccn1Cc1ccccc1,benzene_ring
63264,Modify the molecule Cc1ccccc1[C@H]1CN(C(=O)C(=O)Nc2ccc(F)cc2F)CCO1 by removing a amide.,Cc1ccccc1[C@H]1CN(C(=O)C(=O)Nc2ccc(F)cc2F)CCO1,amide
133571,Modify the molecule C[C@@H](Cc1nc2ccccc2s1)N[C@H](C)c1cn(-c2ccccc2)nn1 by removing a benzene_ring.,C[C@@H](Cc1nc2ccccc2s1)N[C@H](C)c1cn(-c2ccccc2)nn1,benzene_ring
234871,Please remove a benzene_ring from the molecule CC[S@](=O)[C@@H]1CCCC[C@@H]1NC(=O)NC(C)(C)c1cccc(C)c1.,CC[S@](=O)[C@@H]1CCCC[C@@H]1NC(=O)NC(C)(C)c1cccc(C)c1,benzene_ring
109403,Modify the molecule Fc1ccc(OCC2=NN3[C@@H]([C@H]4C=c5ccccc5=[NH+]4)NN[C@H]3S2)cc1 by removing a amine.,Fc1ccc(OCC2=NN3[C@@H]([C@H]4C=c5ccccc5=[NH+]4)NN[C@H]3S2)cc1,amine
105219,Modify the molecule Cc1ccc(S(=O)(=O)N(C)c2ccc(O[C@H](C)C(=O)Nc3c(C)cc(C)cc3C)cc2)cc1 by removing a benzene_ring.,Cc1ccc(S(=O)(=O)N(C)c2ccc(O[C@H](C)C(=O)Nc3c(C)cc(C)cc3C)cc2)cc1,benzene_ring
23956,Modify the molecule Cc1ccc(NC(=S)NC(=O)c2ccccc2[N+](=O)[O-])c(C)c1 by removing a benzene_ring.,Cc1ccc(NC(=S)NC(=O)c2ccccc2[N+](=O)[O-])c(C)c1,benzene_ring
71959,Modify the molecule Cn1c(N2CC[C@H](O)C2)nc2cc(C(=O)NCCCOc3ccccc3)ccc21 by removing a amide.,Cn1c(N2CC[C@H](O)C2)nc2cc(C(=O)NCCCOc3ccccc3)ccc21,amide
107238,Modify the molecule O=C(/C=C/c1ccc(F)cc1)NC(=S)NNS(=O)(=O)c1ccccc1 by removing a amide.,O=C(/C=C/c1ccc(F)cc1)NC(=S)NNS(=O)(=O)c1ccccc1,amide
117390,Modify the molecule CNC(=O)CN1CCC([NH2+][C@@H](c2c(Cl)cccc2Cl)C(C)C)CC1 by removing a benzene_ring.,CNC(=O)CN1CCC([NH2+][C@@H](c2c(Cl)cccc2Cl)C(C)C)CC1,benzene_ring
105500,Please remove a benzene_ring from the molecule COc1cc(CN(C)C[C@H](O)CN2CCOCC2)cc(Br)c1O.,COc1cc(CN(C)C[C@H](O)CN2CCOCC2)cc(Br)c1O,benzene_ring
89300,Please remove a amide from the molecule COC(=O)CN(C(=O)c1cnc([C@@H]2CCCO2)s1)c1cccc(F)c1.,COC(=O)CN(C(=O)c1cnc([C@@H]2CCCO2)s1)c1cccc(F)c1,amide
8140,Remove a amine from the molecule Cc1ccc(NC(=O)[C@@H](Sc2nnc(-c3cccnc3)n2N)c2ccccc2)cc1.,Cc1ccc(NC(=O)[C@@H](Sc2nnc(-c3cccnc3)n2N)c2ccccc2)cc1,amine
130924,Please remove a amide from the molecule Cn1c(-c2ccccn2)nn(CCNC(=O)c2ccco2)c1=O.,Cn1c(-c2ccccn2)nn(CCNC(=O)c2ccco2)c1=O,amide
93496,Please remove a benzene_ring from the molecule Cc1ccc([C@@H]2C3=C([O-])CCCC3=NC3=NC(SCC(=O)NCc4ccccc4)=NC(=O)[C@H]32)cc1.,Cc1ccc([C@@H]2C3=C([O-])CCCC3=NC3=NC(SCC(=O)NCc4ccccc4)=NC(=O)[C@H]32)cc1,benzene_ring
218148,Modify the molecule COc1ccc(OC)c(NC(=O)[C@H]2C[C@H](CCSC)N[C@]23C(=O)Nc2c(C)cc(Cl)cc23)c1 by removing a amine.,COc1ccc(OC)c(NC(=O)[C@H]2C[C@H](CCSC)N[C@]23C(=O)Nc2c(C)cc(Cl)cc23)c1,amine
54295,Please remove a halo from the molecule OC[C@H]1C[C@@H]1c1ccccc1Cl.,OC[C@H]1C[C@@H]1c1ccccc1Cl,halo
73447,Modify the molecule C[C@H]1CCC[C@H](C)C1NC(=O)/C=C/c1ccc(N2CCCS2(=O)=O)cc1 by removing a amide.,C[C@H]1CCC[C@H](C)C1NC(=O)/C=C/c1ccc(N2CCCS2(=O)=O)cc1,amide
47742,Please remove a halo from the molecule CCc1nc(CC[NH2+]Cc2cc(=O)c3cc(F)ccc3[nH]2)cs1.,CCc1nc(CC[NH2+]Cc2cc(=O)c3cc(F)ccc3[nH]2)cs1,halo
59428,Modify the molecule CC(=O)N1C=Cc2ccccc2[C@H]1CC(=O)NC[C@H](CC(C)C)[NH+](C)C by removing a amide.,CC(=O)N1C=Cc2ccccc2[C@H]1CC(=O)NC[C@H](CC(C)C)[NH+](C)C,amide
55436,Please remove a benzene_ring from the molecule C[C@@H](C(=O)N(C)C1CCCCC1)n1nnc(-c2ccccc2)n1.,C[C@@H](C(=O)N(C)C1CCCCC1)n1nnc(-c2ccccc2)n1,benzene_ring
174828,Please remove a amine from the molecule CCCN[C@@]1(C(=O)[O-])CC[C@H]([NH+]2CCC[C@@H]2C)C1.,CCCN[C@@]1(C(=O)[O-])CC[C@H]([NH+]2CCC[C@@H]2C)C1,amine
233722,Please remove a halo from the molecule C[C@H](SCc1ccnn1C)c1ccc(F)c(F)c1.,C[C@H](SCc1ccnn1C)c1ccc(F)c(F)c1,halo
111672,Please remove a benzene_ring from the molecule COc1cc(OC)cc([C@@H]2CCN(C(=O)N[C@@H]3C[C@@H]3c3ccccc3)C2)c1.,COc1cc(OC)cc([C@@H]2CCN(C(=O)N[C@@H]3C[C@@H]3c3ccccc3)C2)c1,benzene_ring
112674,Please remove a benzene_ring from the molecule COc1cc2c(cc1OC)C[NH+](Cn1nc(-c3ccc(Cl)cc3)n(C)c1=S)CC2.,COc1cc2c(cc1OC)C[NH+](Cn1nc(-c3ccc(Cl)cc3)n(C)c1=S)CC2,benzene_ring
1518,Remove a amide from the molecule CCc1nc(C)sc1CNC(=O)CCc1nc(-c2ccccc2C)no1.,CCc1nc(C)sc1CNC(=O)CCc1nc(-c2ccccc2C)no1,amide
114196,Please remove a amide from the molecule Cc1ccc(S(=O)(=O)[C@H](C)C(=O)Nc2c(C)cccc2C)cc1C.,Cc1ccc(S(=O)(=O)[C@H](C)C(=O)Nc2c(C)cccc2C)cc1C,amide
50658,Modify the molecule Cc1ccc(N2CC[C@H](Nc3ccc([N+](=O)[O-])nc3)C2=O)cc1 by removing a benzene_ring.,Cc1ccc(N2CC[C@H](Nc3ccc([N+](=O)[O-])nc3)C2=O)cc1,benzene_ring
26161,Remove a nitrile from the molecule CC(C)[C@@H](NC(=O)/C=C/c1ccc(OCC#N)cc1)c1ccccn1.,CC(C)[C@@H](NC(=O)/C=C/c1ccc(OCC#N)cc1)c1ccccn1,nitrile
201943,Remove a hydroxyl from the molecule C[C@H](C/C(N)=N/O)N1CC[NH+]2CCC[C@@H]2C1.,C[C@H](C/C(N)=N/O)N1CC[NH+]2CCC[C@@H]2C1,hydroxyl
172184,Remove a benzene_ring from the molecule Cc1nc(CNc2ccccc2OC[C@H]2CCCCO2)sc1C.,Cc1nc(CNc2ccccc2OC[C@H]2CCCCO2)sc1C,benzene_ring
61402,Modify the molecule COc1cccc([C@@H](CNC(=O)Nc2ccc(C(N)=O)c(C)c2)[NH+](C)C)c1 by removing a benzene_ring.,COc1cccc([C@@H](CNC(=O)Nc2ccc(C(N)=O)c(C)c2)[NH+](C)C)c1,benzene_ring
135923,Please remove a amide from the molecule CC(C)(C)c1ncc(NC(=O)Cc2csc(-c3cnccn3)n2)cn1.,CC(C)(C)c1ncc(NC(=O)Cc2csc(-c3cnccn3)n2)cn1,amide
158957,Modify the molecule O=C(NCCC(=O)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1)Nc1ccccc1 by removing a halo.,O=C(NCCC(=O)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1)Nc1ccccc1,halo
179455,Remove a benzene_ring from the molecule Cc1n[nH]c(SCCC(=O)NCc2ccc(N(C)C)cc2C)n1.,Cc1n[nH]c(SCCC(=O)NCc2ccc(N(C)C)cc2C)n1,benzene_ring
131661,Please remove a amide from the molecule Cc1cc(C(=O)NCCCSc2nccs2)c(C)o1.,Cc1cc(C(=O)NCCCSc2nccs2)c(C)o1,amide
54088,Remove a benzene_ring from the molecule COc1ccc(C[C@H]([NH3+])Cc2ccc(O)cc2)cn1.,COc1ccc(C[C@H]([NH3+])Cc2ccc(O)cc2)cn1,benzene_ring
165631,Please remove a amide from the molecule O=C(N[C@@H](C(=O)N/N=C\C=C\c1ccccc1)c1n[nH]c(=O)c2ccccc12)c1ccccc1.,O=C(N[C@@H](C(=O)N/N=C\C=C\c1ccccc1)c1n[nH]c(=O)c2ccccc12)c1ccccc1,amide
12069,Modify the molecule C[NH+]1CCN(C[C@@H](O)COc2cccc(C[NH3+])c2)CC1 by removing a benzene_ring.,C[NH+]1CCN(C[C@@H](O)COc2cccc(C[NH3+])c2)CC1,benzene_ring
38815,Please remove a benzene_ring from the molecule CC[NH2+][C@@H](C(C)C)[C@H](C)c1cc(C)ccc1C.,CC[NH2+][C@@H](C(C)C)[C@H](C)c1cc(C)ccc1C,benzene_ring
208100,Modify the molecule CCCc1cc(NC(=O)N(C)Cc2ccc(F)cc2Cl)n(C)n1 by removing a halo.,CCCc1cc(NC(=O)N(C)Cc2ccc(F)cc2Cl)n(C)n1,halo
1927,Remove a amide from the molecule Cc1nc(-c2cccc(Cl)c2)sc1C(=O)N[C@H]1CC[C@@H]([NH+](C)C)C1.,Cc1nc(-c2cccc(Cl)c2)sc1C(=O)N[C@H]1CC[C@@H]([NH+](C)C)C1,amide
162996,Modify the molecule COc1ccc(CN2CC[NH+](Cc3cccc(C)c3)CC2)cc1Br by removing a benzene_ring.,COc1ccc(CN2CC[NH+](Cc3cccc(C)c3)CC2)cc1Br,benzene_ring
114197,Modify the molecule CCn1nc(C)c(NC(=O)C[C@H]2Oc3ccccc3NC2=O)c1C by removing a amide.,CCn1nc(C)c(NC(=O)C[C@H]2Oc3ccccc3NC2=O)c1C,amide
76779,Remove a amide from the molecule CCc1nn(C)cc1NC(=O)CCn1c(C)csc1=O.,CCc1nn(C)cc1NC(=O)CCn1c(C)csc1=O,amide
35000,Remove a amide from the molecule COC(CNC(=O)CN1CC[NH2+]CC1)OC.,COC(CNC(=O)CN1CC[NH2+]CC1)OC,amide
140664,Modify the molecule Cc1cc(C)cc(O[C@@H](C)C(=O)N(Cc2ccc(F)cc2)[C@@H]2CCS(=O)(=O)C2)c1 by removing a halo.,Cc1cc(C)cc(O[C@@H](C)C(=O)N(Cc2ccc(F)cc2)[C@@H]2CCS(=O)(=O)C2)c1,halo
88597,Please remove a benzene_ring from the molecule O=C(NCC[NH+]1CCC(c2ccsc2)CC1)c1ccc(F)cc1Cl.,O=C(NCC[NH+]1CCC(c2ccsc2)CC1)c1ccc(F)cc1Cl,benzene_ring
196700,Remove a amide from the molecule Cc1cc(C)cc(-n2cc(C(=O)N3CCC(C)CC3)nn2)c1.,Cc1cc(C)cc(-n2cc(C(=O)N3CCC(C)CC3)nn2)c1,amide
167343,Remove a amine from the molecule COc1ccc(/C=[NH+]\C[C@H]2COc3ccccc3O2)c(OC)c1.,COc1ccc(/C=[NH+]\C[C@H]2COc3ccccc3O2)c(OC)c1,amine
238279,Remove a benzene_ring from the molecule CO[C@H]1CCCN(C(=O)N[C@@H](C)c2cnn(-c3ccccc3)c2C)C1.,CO[C@H]1CCCN(C(=O)N[C@@H](C)c2cnn(-c3ccccc3)c2C)C1,benzene_ring
149280,Remove a amide from the molecule Cc1cc(C)c(C[S@](=O)CC(=O)N(C)c2ccccc2)c(C)c1.,Cc1cc(C)c(C[S@](=O)CC(=O)N(C)c2ccccc2)c(C)c1,amide
186507,Remove a halo from the molecule Cc1ccc(-n2c([C@H](C)Cl)nc3cc(C)cnc32)c(C)c1.,Cc1ccc(-n2c([C@H](C)Cl)nc3cc(C)cnc32)c(C)c1,halo
148771,Please remove a benzene_ring from the molecule C[C@H](CN(C(=O)c1ccoc1)c1ccccc1)NC(=O)c1ccoc1.,C[C@H](CN(C(=O)c1ccoc1)c1ccccc1)NC(=O)c1ccoc1,benzene_ring
12561,Remove a benzene_ring from the molecule Cc1ccc(-n2cnnn2)cc1NC(=O)[C@@H]1C=C[C@@H]([NH3+])C1.,Cc1ccc(-n2cnnn2)cc1NC(=O)[C@@H]1C=C[C@@H]([NH3+])C1,benzene_ring
119261,Please remove a amide from the molecule CCOC[C@@H]1CCN(C(=O)[C@@H](C)Sc2nnnn2C2CC2)C1.,CCOC[C@@H]1CCN(C(=O)[C@@H](C)Sc2nnnn2C2CC2)C1,amide
180592,Please remove a amide from the molecule Cc1cc(NC(=O)CSc2nnnn2C2CCCC2)n(-c2ccccc2)n1.,Cc1cc(NC(=O)CSc2nnnn2C2CCCC2)n(-c2ccccc2)n1,amide
4571,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)[C@H]2CSCCS2)cc1C.,Cc1ccc(C(=O)[C@H]2CSCCS2)cc1C,benzene_ring
138682,Modify the molecule C[NH2+]Cc1ccccc1NC(=O)C1C(C)(C)C1(C)C by removing a benzene_ring.,C[NH2+]Cc1ccccc1NC(=O)C1C(C)(C)C1(C)C,benzene_ring
216572,Remove a amide from the molecule O=C(c1ccc([C@H]2CCC[NH2+]2)s1)N1CCC(CN2CCOCC2)CC1.,O=C(c1ccc([C@H]2CCC[NH2+]2)s1)N1CCC(CN2CCOCC2)CC1,amide
204546,Remove a amide from the molecule CCC(=O)N1CCC[C@H](COc2ccc(C(=O)N3CCCCC3)cc2)C1.,CCC(=O)N1CCC[C@H](COc2ccc(C(=O)N3CCCCC3)cc2)C1,amide
51575,Modify the molecule CC(C)[C@@H](NC(=O)C(=O)Nc1ccc2c(c1)CCC(=O)N2)c1ccccc1 by removing a amide.,CC(C)[C@@H](NC(=O)C(=O)Nc1ccc2c(c1)CCC(=O)N2)c1ccccc1,amide
19780,Remove a benzene_ring from the molecule Cc1ccc(S[C@H]2CSc3nc(C)cc(=O)n3[C@@H]2c2ccccc2)cc1.,Cc1ccc(S[C@H]2CSc3nc(C)cc(=O)n3[C@@H]2c2ccccc2)cc1,benzene_ring
24317,Modify the molecule C[C@@H]1C(=O)CCN(c2ccc(F)cc2F)[C@H]1C by removing a benzene_ring.,C[C@@H]1C(=O)CCN(c2ccc(F)cc2F)[C@H]1C,benzene_ring
173479,Please remove a amide from the molecule CCN(C(=O)Cc1ccc(F)c(F)c1)[C@@H]1CCC[C@H]1C[NH3+].,CCN(C(=O)Cc1ccc(F)c(F)c1)[C@@H]1CCC[C@H]1C[NH3+],amide
6403,Modify the molecule O=C(NC[C@@H]1CC[NH+](Cc2cccc(O)c2)C1)c1cc2ccccc2[nH]1 by removing a amide.,O=C(NC[C@@H]1CC[NH+](Cc2cccc(O)c2)C1)c1cc2ccccc2[nH]1,amide
137534,Please remove a amine from the molecule Cc1c(F)cccc1-c1ccc(CN[C@@H](CO)c2ccco2)o1.,Cc1c(F)cccc1-c1ccc(CN[C@@H](CO)c2ccco2)o1,amine
71341,Modify the molecule Cc1ccccc1C[NH2+]CC1CC[NH2+]CC1 by removing a benzene_ring.,Cc1ccccc1C[NH2+]CC1CC[NH2+]CC1,benzene_ring
34245,Remove a amide from the molecule Cc1cccc(C)c1N1CCN(C(=O)c2ccccc2Cl)CC1.,Cc1cccc(C)c1N1CCN(C(=O)c2ccccc2Cl)CC1,amide
18884,Modify the molecule COc1ccc(O)c([C@H](C)NC(=O)Nc2cccc(C)c2Cl)c1 by removing a hydroxyl.,COc1ccc(O)c([C@H](C)NC(=O)Nc2cccc(C)c2Cl)c1,hydroxyl
8154,Please remove a hydroxyl from the molecule COc1cc(CN2CCC([NH+]3CCC[C@@H]3C)CC2)cc([N+](=O)[O-])c1O.,COc1cc(CN2CCC([NH+]3CCC[C@@H]3C)CC2)cc([N+](=O)[O-])c1O,hydroxyl
19498,Remove a amide from the molecule Cc1nnc2ccc(C(=O)N3CCCCC[C@H]3c3cccn3C)cn12.,Cc1nnc2ccc(C(=O)N3CCCCC[C@H]3c3cccn3C)cn12,amide
64782,Modify the molecule OCC[NH+]1CCN(C(=S)NCc2ccco2)CC1 by removing a amine.,OCC[NH+]1CCN(C(=S)NCc2ccco2)CC1,amine
88735,Please remove a nitrile from the molecule C[C@H]1CO[C@@H](c2ccccc2)[C@H](C)N1Cc1cnc2ccc(C#N)cn12.,C[C@H]1CO[C@@H](c2ccccc2)[C@H](C)N1Cc1cnc2ccc(C#N)cn12,nitrile
128684,Modify the molecule C[C@H]1CCCC[C@H]1NC(=O)C(=O)Nc1ccc(Cl)c(C(=O)NC2CC2)c1 by removing a halo.,C[C@H]1CCCC[C@H]1NC(=O)C(=O)Nc1ccc(Cl)c(C(=O)NC2CC2)c1,halo
152276,Modify the molecule C[C@@H](C(=O)NCc1ccc(F)cc1)C1CCN(S(=O)(=O)c2ccc(Cl)s2)CC1 by removing a benzene_ring.,C[C@@H](C(=O)NCc1ccc(F)cc1)C1CCN(S(=O)(=O)c2ccc(Cl)s2)CC1,benzene_ring
15721,Please remove a halo from the molecule COc1ccc(S(=O)(=O)NC[C@@H]2CCN(c3ccc(F)c(F)c3)C2)cc1C.,COc1ccc(S(=O)(=O)NC[C@@H]2CCN(c3ccc(F)c(F)c3)C2)cc1C,halo
216083,Modify the molecule Cc1nnc2ccc(Nc3ccc4oc(=O)n(CC[NH+](C)C)c4c3)nn12 by removing a amine.,Cc1nnc2ccc(Nc3ccc4oc(=O)n(CC[NH+](C)C)c4c3)nn12,amine
52058,Please remove a benzene_ring from the molecule Nc1ccc(CCNC(=O)Cc2ccc(F)c(F)c2)cc1.,Nc1ccc(CCNC(=O)Cc2ccc(F)c(F)c2)cc1,benzene_ring
220510,Remove a amide from the molecule COc1ccccc1C[NH+]1CCC(Oc2ccc(C(=O)NC3CCCC3)cc2Cl)CC1.,COc1ccccc1C[NH+]1CCC(Oc2ccc(C(=O)NC3CCCC3)cc2Cl)CC1,amide
186841,Modify the molecule CCCC(=O)N1CCC[C@@H](C(=O)N[C@H]2C[C@H]2CCC)C1 by removing a amide.,CCCC(=O)N1CCC[C@@H](C(=O)N[C@H]2C[C@H]2CCC)C1,amide
171856,Remove a amide from the molecule CCCOc1ccc(NC(=O)CNC(C)=O)cc1Cl.,CCCOc1ccc(NC(=O)CNC(C)=O)cc1Cl,amide
38876,Please remove a benzene_ring from the molecule Cc1[nH]c(=O)c(C(=O)OC[C@@H]2C[C@H]2C)cc1-c1ccccc1.,Cc1[nH]c(=O)c(C(=O)OC[C@@H]2C[C@H]2C)cc1-c1ccccc1,benzene_ring
119552,Modify the molecule O=C(NCc1ccc(Cl)cc1)c1ccc(CNc2c(O)c(=O)c2=[N+]2CCCCC2)cc1 by removing a amine.,O=C(NCc1ccc(Cl)cc1)c1ccc(CNc2c(O)c(=O)c2=[N+]2CCCCC2)cc1,amine
210836,Please remove a amide from the molecule CC(C)N(Cc1cccnc1)C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O.,CC(C)N(Cc1cccnc1)C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O,amide
239779,Modify the molecule O=C([O-])c1cncc(Nc2ccc(Cl)cc2C(F)(F)F)n1 by removing a halo.,O=C([O-])c1cncc(Nc2ccc(Cl)cc2C(F)(F)F)n1,halo
181976,Modify the molecule CC[C@H]1CC[NH+](Cc2cc(Cl)ccc2O)C1 by removing a halo.,CC[C@H]1CC[NH+](Cc2cc(Cl)ccc2O)C1,halo
138514,Remove a amine from the molecule CNC(=S)Nc1n[nH]c(SC)n1.,CNC(=S)Nc1n[nH]c(SC)n1,amine
248091,Please remove a amide from the molecule O=C(C1=C[C@H]2N=CC=C2C=C1)N(Cc1cccnc1)CC1CC[NH+](C2CCCC2)CC1.,O=C(C1=C[C@H]2N=CC=C2C=C1)N(Cc1cccnc1)CC1CC[NH+](C2CCCC2)CC1,amide
200254,Remove a halo from the molecule CC[C@H]1CCC(=O)[C@H](Cc2cc(Cl)ccc2[N+](=O)[O-])C1.,CC[C@H]1CCC(=O)[C@H](Cc2cc(Cl)ccc2[N+](=O)[O-])C1,halo
15183,Modify the molecule CCOC(=O)C1=C(N)Oc2cc(C)n(CC[NH+](C)C)c(=O)c2[C@H]1c1ccc(Cl)cc1 by removing a amine.,CCOC(=O)C1=C(N)Oc2cc(C)n(CC[NH+](C)C)c(=O)c2[C@H]1c1ccc(Cl)cc1,amine
67270,Please remove a benzene_ring from the molecule Cc1ccc([S@@](=O)[C@H]2CCC(C)(C)[C@@H]2[NH3+])cc1C.,Cc1ccc([S@@](=O)[C@H]2CCC(C)(C)[C@@H]2[NH3+])cc1C,benzene_ring
190042,Remove a benzene_ring from the molecule O=C(NC(=S)N1CCOCC1)c1ccccc1C(=O)OCC(F)(F)F.,O=C(NC(=S)N1CCOCC1)c1ccccc1C(=O)OCC(F)(F)F,benzene_ring
135199,Please remove a amide from the molecule Cn1cccc(NC(=O)C(=O)N2CC[C@@H](Cc3ccccc3)C2)c1=O.,Cn1cccc(NC(=O)C(=O)N2CC[C@@H](Cc3ccccc3)C2)c1=O,amide
21721,Please remove a amide from the molecule Cc1nc(CN(C)C(=O)[C@@H]2CC[NH2+][C@H]2C)n[nH]1.,Cc1nc(CN(C)C(=O)[C@@H]2CC[NH2+][C@H]2C)n[nH]1,amide
89615,Remove a benzene_ring from the molecule CC(=O)c1ccc(S(=O)(=O)N(C)Cc2ccc([C@H]3C[C@@H]3C)o2)cc1.,CC(=O)c1ccc(S(=O)(=O)N(C)Cc2ccc([C@H]3C[C@@H]3C)o2)cc1,benzene_ring
145981,Modify the molecule Cc1cc(C)c2c3ccccc3n(CCNC(=O)c3cccc4cccnc34)c2n1 by removing a amide.,Cc1cc(C)c2c3ccccc3n(CCNC(=O)c3cccc4cccnc34)c2n1,amide
239626,Remove a amide from the molecule COc1cc2c(cc1OC)[C@@]1(Cc3ccc(Cl)cc3)[C@@H]3CC=CC[C@@H]3C(=O)N1CC2.,COc1cc2c(cc1OC)[C@@]1(Cc3ccc(Cl)cc3)[C@@H]3CC=CC[C@@H]3C(=O)N1CC2,amide
177278,Remove a amide from the molecule C=CCN1C[C@H](C(=O)Cl)CC1=O.,C=CCN1C[C@H](C(=O)Cl)CC1=O,amide
245779,Remove a benzene_ring from the molecule Cc1ccc(-c2ccc(=O)n(Cc3noc(C(=O)N4CCCC4)n3)n2)cc1C.,Cc1ccc(-c2ccc(=O)n(Cc3noc(C(=O)N4CCCC4)n3)n2)cc1C,benzene_ring
160211,Modify the molecule NS(=O)(=O)CCN(CCO)Cc1cc(Br)ccc1F by removing a halo.,NS(=O)(=O)CCN(CCO)Cc1cc(Br)ccc1F,halo
133449,Modify the molecule COc1ccc([C@@H](C)[C@H](C)[NH2+]C2CCN(S(=O)(=O)C3CC3)CC2)cc1 by removing a benzene_ring.,COc1ccc([C@@H](C)[C@H](C)[NH2+]C2CCN(S(=O)(=O)C3CC3)CC2)cc1,benzene_ring
76853,Remove a benzene_ring from the molecule c1ccc(-c2cc(N3CCC[C@@H](Cn4cc[nH+]c4)C3)n3nccc3n2)cc1.,c1ccc(-c2cc(N3CCC[C@@H](Cn4cc[nH+]c4)C3)n3nccc3n2)cc1,benzene_ring
64542,Remove a amide from the molecule C[C@@H](NC(=O)CN1CCCC1=O)c1cccc2ccccc12.,C[C@@H](NC(=O)CN1CCCC1=O)c1cccc2ccccc12,amide
49854,Modify the molecule O=C(Nc1ccc(OC(F)F)cc1)[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 by removing a amide.,O=C(Nc1ccc(OC(F)F)cc1)[C@@H]1CCCCN1S(=O)(=O)c1ccccc1,amide
72889,Remove a amine from the molecule Cc1nnc2ccc(N[C@H](C)C(=O)N3CCOCC3)nn12.,Cc1nnc2ccc(N[C@H](C)C(=O)N3CCOCC3)nn12,amine
217840,Please remove a amine from the molecule O=[N+]([O-])c1cccnc1N[C@H]1c2ccccc2C[C@H]1O.,O=[N+]([O-])c1cccnc1N[C@H]1c2ccccc2C[C@H]1O,amine
154132,Please remove a halo from the molecule Cc1nn(C(=O)OC(C)(C)C)c(C)c1Br.,Cc1nn(C(=O)OC(C)(C)C)c(C)c1Br,halo
109418,Modify the molecule C[C@H]1C[NH+]2CCC[C@@H]2CN1c1cc(Cl)ccc1C(=O)[O-] by removing a benzene_ring.,C[C@H]1C[NH+]2CCC[C@@H]2CN1c1cc(Cl)ccc1C(=O)[O-],benzene_ring
100088,Remove a amide from the molecule C=CC(=O)N[C@@H](C)c1nc2ccccc2n1C.,C=CC(=O)N[C@@H](C)c1nc2ccccc2n1C,amide
186730,Modify the molecule CCN(C[C@@H](C)C#N)C(=O)Nc1c(C(C)C)cccc1C(C)C by removing a benzene_ring.,CCN(C[C@@H](C)C#N)C(=O)Nc1c(C(C)C)cccc1C(C)C,benzene_ring
125743,Remove a amide from the molecule O=C(CC1(O)CCCC1)NCc1cn2cc(Br)ccc2n1.,O=C(CC1(O)CCCC1)NCc1cn2cc(Br)ccc2n1,amide
163840,Please remove a nitrile from the molecule N#C[C@H]1C(=O)NC(=S)[C@@H](C(N)=O)C12CCCCC2.,N#C[C@H]1C(=O)NC(=S)[C@@H](C(N)=O)C12CCCCC2,nitrile
97706,Modify the molecule COC(=O)c1cc2n(n1)CCN(C(=O)c1cc(-c3ccccc3O)n[nH]1)C2 by removing a amide.,COC(=O)c1cc2n(n1)CCN(C(=O)c1cc(-c3ccccc3O)n[nH]1)C2,amide
46258,Modify the molecule C[C@@H]1C[C@H]1N1C[C@H](NC(=O)Cc2cccc(O)c2)CC1=O by removing a amide.,C[C@@H]1C[C@H]1N1C[C@H](NC(=O)Cc2cccc(O)c2)CC1=O,amide
35311,Please remove a benzene_ring from the molecule CS(=O)(=O)c1ccccc1C(=O)Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1.,CS(=O)(=O)c1ccccc1C(=O)Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1,benzene_ring
175858,Please remove a benzene_ring from the molecule CC[C@H]1CCN(C(=O)Nc2cccc(CS(=O)(=O)N[C@H](C)CC)c2)C1.,CC[C@H]1CCN(C(=O)Nc2cccc(CS(=O)(=O)N[C@H](C)CC)c2)C1,benzene_ring
206081,Please remove a halo from the molecule CC[NH+](CCC(=O)Nc1ccc(F)cc1N)C(C)C.,CC[NH+](CCC(=O)Nc1ccc(F)cc1N)C(C)C,halo
113735,Modify the molecule CCc1cccc(NC(=O)c2cc(C)c(C#CCO)s2)c1 by removing a amide.,CCc1cccc(NC(=O)c2cc(C)c(C#CCO)s2)c1,amide
54729,Remove a amide from the molecule N/C(=N/OCC(=O)N1CCCCCCC1)c1cnccn1.,N/C(=N/OCC(=O)N1CCCCCCC1)c1cnccn1,amide
73946,Remove a hydroxyl from the molecule C/C(=N\O)[C@H]1C[C@H]2C=C(C#N)[C@@H]1[NH+](Cc1ccccc1)C2.,C/C(=N\O)[C@H]1C[C@H]2C=C(C#N)[C@@H]1[NH+](Cc1ccccc1)C2,hydroxyl
134512,Remove a amide from the molecule C[C@@H]1CCC[C@H]1[NH2+]CCNC(=O)CC1CCCCC1.,C[C@@H]1CCC[C@H]1[NH2+]CCNC(=O)CC1CCCCC1,amide
64649,Remove a benzene_ring from the molecule COc1ccc(-n2cnc3c2N=C(O)C[C@H]3c2ccc(F)cc2)cc1.,COc1ccc(-n2cnc3c2N=C(O)C[C@H]3c2ccc(F)cc2)cc1,benzene_ring
40047,Modify the molecule COc1ccc(NC(=S)NC(=O)C2CCC2)cc1 by removing a amine.,COc1ccc(NC(=S)NC(=O)C2CCC2)cc1,amine
149344,Please remove a amide from the molecule CCOC(=O)[C@H]1C[NH2+]C[C@]12COc1ccccc1C(=O)N2.,CCOC(=O)[C@H]1C[NH2+]C[C@]12COc1ccccc1C(=O)N2,amide
177583,Modify the molecule Cc1occc1C(=O)NCC(=O)NC[C@@H](C)c1nc(-c2ccccc2)no1 by removing a benzene_ring.,Cc1occc1C(=O)NCC(=O)NC[C@@H](C)c1nc(-c2ccccc2)no1,benzene_ring
238478,Please remove a amide from the molecule CC(C)c1ccc2cc(C(=O)N(C)Cc3ccc(Br)o3)[nH]c2c1.,CC(C)c1ccc2cc(C(=O)N(C)Cc3ccc(Br)o3)[nH]c2c1,amide
175797,Please remove a benzene_ring from the molecule Cc1ccc(COc2ccc(-c3nnco3)cc2)cc1.,Cc1ccc(COc2ccc(-c3nnco3)cc2)cc1,benzene_ring
168043,Modify the molecule COc1cc(C(C)=O)ccc1OCC(=O)NC1C[C@@H]2CCC[C@H](C1)[NH+]2C by removing a benzene_ring.,COc1cc(C(C)=O)ccc1OCC(=O)NC1C[C@@H]2CCC[C@H](C1)[NH+]2C,benzene_ring
79043,Modify the molecule CC(C)C[NH+]1CCN(Cn2nnn(-c3ccc(Cl)cc3)c2=S)CC1 by removing a benzene_ring.,CC(C)C[NH+]1CCN(Cn2nnn(-c3ccc(Cl)cc3)c2=S)CC1,benzene_ring
170692,Modify the molecule C[NH2+]Cc1ccccc1O[C@@H](C)C(=O)NC(N)=O by removing a amide.,C[NH2+]Cc1ccccc1O[C@@H](C)C(=O)NC(N)=O,amide
61582,Please remove a nitro from the molecule CCNC(=O)C(=O)N/N=C\c1cc([N+](=O)[O-])ccc1[O-].,CCNC(=O)C(=O)N/N=C\c1cc([N+](=O)[O-])ccc1[O-],nitro
103178,Please remove a benzene_ring from the molecule CCCc1ccc(OCc2cnc(N)s2)cc1.,CCCc1ccc(OCc2cnc(N)s2)cc1,benzene_ring
107466,Modify the molecule COc1ccnc(NC(=O)[C@@H](C)c2ccc(Br)s2)c1 by removing a halo.,COc1ccnc(NC(=O)[C@@H](C)c2ccc(Br)s2)c1,halo
174546,Remove a halo from the molecule [NH2+]=c1oc2ccc(Br)cc2cc1C(=O)NCc1cccnc1.,[NH2+]=c1oc2ccc(Br)cc2cc1C(=O)NCc1cccnc1,halo
223533,Remove a amide from the molecule C[C@H](NC(=O)CCn1ccccc1=O)C(=O)[O-].,C[C@H](NC(=O)CCn1ccccc1=O)C(=O)[O-],amide
201022,Modify the molecule O[C@H]1CCCC[C@H]1Sc1nnc(-c2ccc(Cl)s2)o1 by removing a halo.,O[C@H]1CCCC[C@H]1Sc1nnc(-c2ccc(Cl)s2)o1,halo
26235,Please remove a amide from the molecule CC[NH+](C)CC(=O)NC[C@H]1CN(CC(C)C)CCO1.,CC[NH+](C)CC(=O)NC[C@H]1CN(CC(C)C)CCO1,amide
22265,Remove a amide from the molecule O=C([O-])COCC(=O)Nc1ccc2c(c1)CCCC2.,O=C([O-])COCC(=O)Nc1ccc2c(c1)CCCC2,amide
36182,Modify the molecule O=C(Nc1ccnn1Cc1cccc2ccccc12)c1cccnc1Cl by removing a amide.,O=C(Nc1ccnn1Cc1cccc2ccccc12)c1cccnc1Cl,amide
46096,Remove a amide from the molecule CCc1cc(=O)n2c(n1)SC[C@@H]2CC(=O)Nc1ccccc1OC.,CCc1cc(=O)n2c(n1)SC[C@@H]2CC(=O)Nc1ccccc1OC,amide
70190,Please remove a amide from the molecule CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)Nc2ccc(C(=O)NC)cc2)C1.,CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)Nc2ccc(C(=O)NC)cc2)C1,amide
162466,Please remove a benzene_ring from the molecule CNc1ccc(C(=O)[O-])cc1C(=O)[O-].,CNc1ccc(C(=O)[O-])cc1C(=O)[O-],benzene_ring
191171,Remove a halo from the molecule C/C(=C\c1ccc(F)cc1)C(=O)OC[C@H]1CCCO1.,C/C(=C\c1ccc(F)cc1)C(=O)OC[C@H]1CCCO1,halo
131543,Please remove a benzene_ring from the molecule CN(C)c1ccc(C[C@H](C(N)=S)c2nc3ccccc3[nH]2)cc1.,CN(C)c1ccc(C[C@H](C(N)=S)c2nc3ccccc3[nH]2)cc1,benzene_ring
141084,Modify the molecule CCn1c(=O)n(CC(=O)N2CCn3c(C)nnc3C2)c2ccccc21 by removing a amide.,CCn1c(=O)n(CC(=O)N2CCn3c(C)nnc3C2)c2ccccc21,amide
75068,Please remove a benzene_ring from the molecule CC(=O)N1CCc2ccccc2[C@H]1CC(=O)O[C@@H](C)c1cccc(F)c1.,CC(=O)N1CCc2ccccc2[C@H]1CC(=O)O[C@@H](C)c1cccc(F)c1,benzene_ring
39831,Remove a amide from the molecule O=C(Nc1cc(F)ccc1Cl)[C@@H](O)c1ccccc1.,O=C(Nc1cc(F)ccc1Cl)[C@@H](O)c1ccccc1,amide
97439,Modify the molecule CN(C)C(=O)c1cccc(S(=O)(=O)N2CCCc3cccc(F)c32)c1 by removing a benzene_ring.,CN(C)C(=O)c1cccc(S(=O)(=O)N2CCCc3cccc(F)c32)c1,benzene_ring
203090,Please remove a amide from the molecule Cc1ccc([C@H]2[C@@H](C(=O)N[C@@H](C)c3nc4ccccc4o3)CCC(=O)N2C)cc1.,Cc1ccc([C@H]2[C@@H](C(=O)N[C@@H](C)c3nc4ccccc4o3)CCC(=O)N2C)cc1,amide
232374,Please remove a amide from the molecule CCOc1ccc(-c2nc(C(=O)N3CCNC(=O)[C@@H]3CC)cs2)cc1.,CCOc1ccc(-c2nc(C(=O)N3CCNC(=O)[C@@H]3CC)cs2)cc1,amide
81903,Please remove a amide from the molecule C=CCN(C(=O)[C@@H]1CS[C@@]2(C)CCC(=O)N12)c1nc2c(s1)CCCC2.,C=CCN(C(=O)[C@@H]1CS[C@@]2(C)CCC(=O)N12)c1nc2c(s1)CCCC2,amide
89947,Remove a amine from the molecule CO[C@@H](C)/C(N)=N/OCCOC1CCCCCC1.,CO[C@@H](C)/C(N)=N/OCCOC1CCCCCC1,amine
226041,Please remove a nitrile from the molecule C[C@@H](CC#N)N(C)C(=O)Nc1ccc(Cl)cc1F.,C[C@@H](CC#N)N(C)C(=O)Nc1ccc(Cl)cc1F,nitrile
211269,Remove a halo from the molecule O=C(NCC[NH+]1CCC(CO)CC1)Nc1ccc(C(F)(F)F)cc1.,O=C(NCC[NH+]1CCC(CO)CC1)Nc1ccc(C(F)(F)F)cc1,halo
118419,Remove a halo from the molecule Cc1cc(N(CCC(F)(F)F)CC2CC2)nc(-c2ccccn2)n1.,Cc1cc(N(CCC(F)(F)F)CC2CC2)nc(-c2ccccn2)n1,halo
97248,Please remove a benzene_ring from the molecule NC(=O)N1CCC[C@H](C(=O)Nc2cccc(-c3nc4ccccc4s3)c2)C1.,NC(=O)N1CCC[C@H](C(=O)Nc2cccc(-c3nc4ccccc4s3)c2)C1,benzene_ring
115897,Remove a amide from the molecule CC(=O)c1cccc(OCC2=C[C@@H](C(=O)NCc3ccco3)N=N2)c1.,CC(=O)c1cccc(OCC2=C[C@@H](C(=O)NCc3ccco3)N=N2)c1,amide
170866,Please remove a benzene_ring from the molecule CCCNc1ncnc(Nc2ccc(I)cc2)c1[N+](=O)[O-].,CCCNc1ncnc(Nc2ccc(I)cc2)c1[N+](=O)[O-],benzene_ring
88810,Please remove a amide from the molecule CCc1ccc([C@H](COC)NC(=O)C(=O)Nc2ccc3ncccc3c2)o1.,CCc1ccc([C@H](COC)NC(=O)C(=O)Nc2ccc3ncccc3c2)o1,amide
158687,Remove a nitrile from the molecule C=C(C)COc1nc(C)c2c(c1C#N)CC(C)(C)OC2.,C=C(C)COc1nc(C)c2c(c1C#N)CC(C)(C)OC2,nitrile
246241,Remove a hydroxyl from the molecule O=C([O-])C[C@](O)(c1ccco1)C(F)(F)F.,O=C([O-])C[C@](O)(c1ccco1)C(F)(F)F,hydroxyl
35330,Remove a amine from the molecule CCOc1ccc(S(=O)(=O)NCc2ccco2)cc1C(C)C.,CCOc1ccc(S(=O)(=O)NCc2ccco2)cc1C(C)C,amine
18900,Please remove a amine from the molecule CCn1nc(C(=O)N2CCCC2)c2c1CC[C@@H](NCc1nc(-c3ccccc3)cs1)C2.,CCn1nc(C(=O)N2CCCC2)c2c1CC[C@@H](NCc1nc(-c3ccccc3)cs1)C2,amine
6101,Remove a benzene_ring from the molecule CC[NH2+][C@]1(C(=O)[O-])CCC[C@@H]1CCSc1ccc(C)cc1.,CC[NH2+][C@]1(C(=O)[O-])CCC[C@@H]1CCSc1ccc(C)cc1,benzene_ring
156633,Modify the molecule CCc1noc(C)c1C(=O)Nc1ccc(Cl)cc1C(F)(F)F by removing a halo.,CCc1noc(C)c1C(=O)Nc1ccc(Cl)cc1C(F)(F)F,halo
55822,Modify the molecule CC1(C)CN(C(=O)Cc2ccc(C(F)(F)F)cc2)CC[S@]1=O by removing a halo.,CC1(C)CN(C(=O)Cc2ccc(C(F)(F)F)cc2)CC[S@]1=O,halo
123318,Please remove a amine from the molecule COC1CCN(c2ccc(C(F)(F)F)cc2C(N)=[NH2+])CC1.,COC1CCN(c2ccc(C(F)(F)F)cc2C(N)=[NH2+])CC1,amine
208230,Modify the molecule Cc1nn(C(C)C)c(C)c1S(=O)(=O)[N-]c1cccc(C(=O)[O-])c1C by removing a benzene_ring.,Cc1nn(C(C)C)c(C)c1S(=O)(=O)[N-]c1cccc(C(=O)[O-])c1C,benzene_ring
228388,Please remove a halo from the molecule C[C@H](C(=O)N1CCCC1)N1CCN(c2ccc(Cl)c(C#N)n2)CC1.,C[C@H](C(=O)N1CCCC1)N1CCN(c2ccc(Cl)c(C#N)n2)CC1,halo
86092,Please remove a benzene_ring from the molecule CO/N=C/c1ccc(C(=O)N(C)[C@H](C)c2ccc([S@](C)=O)cc2)cc1.,CO/N=C/c1ccc(C(=O)N(C)[C@H](C)c2ccc([S@](C)=O)cc2)cc1,benzene_ring
136241,Modify the molecule Cc1cc(CC(=O)NCCOc2c(C)cccc2C)no1 by removing a amide.,Cc1cc(CC(=O)NCCOc2c(C)cccc2C)no1,amide
140901,Modify the molecule N#Cc1c(-c2ccc(F)cc2)cc(-c2ccccc2)nc1N by removing a nitrile.,N#Cc1c(-c2ccc(F)cc2)cc(-c2ccccc2)nc1N,nitrile
116479,Modify the molecule CCO[C@@H]1CCCN(C(=O)c2nc(C(C)(C)C)n[nH]2)C1 by removing a amide.,CCO[C@@H]1CCCN(C(=O)c2nc(C(C)(C)C)n[nH]2)C1,amide
187541,Modify the molecule Cc1ccccc1-c1cnc(CNN2CCCCC2)s1 by removing a benzene_ring.,Cc1ccccc1-c1cnc(CNN2CCCCC2)s1,benzene_ring
132929,Modify the molecule Cc1c(Cl)cccc1-n1c(S[C@@H](C)C(N)=O)nc2ccccc2c1=O by removing a halo.,Cc1c(Cl)cccc1-n1c(S[C@@H](C)C(N)=O)nc2ccccc2c1=O,halo
44500,Modify the molecule CC[NH2+][C@@H](CCC(F)(F)F)[C@@H]1C[NH+]2CCN1CC2 by removing a halo.,CC[NH2+][C@@H](CCC(F)(F)F)[C@@H]1C[NH+]2CCN1CC2,halo
191921,Modify the molecule COc1ccccc1[C@@H](O)[C@H](C)C#N by removing a benzene_ring.,COc1ccccc1[C@@H](O)[C@H](C)C#N,benzene_ring
197986,Modify the molecule Cc1cc(F)cc([C@H]([NH3+])Cc2cccc(C(F)(F)F)c2)c1 by removing a benzene_ring.,Cc1cc(F)cc([C@H]([NH3+])Cc2cccc(C(F)(F)F)c2)c1,benzene_ring
86334,Modify the molecule CCOc1ccc(Cl)cc1/C=N/N1C(=O)[C@@H]2C3c4ccccc4C(c4ccccc43)[C@H]2C1=O by removing a benzene_ring.,CCOc1ccc(Cl)cc1/C=N/N1C(=O)[C@@H]2C3c4ccccc4C(c4ccccc43)[C@H]2C1=O,benzene_ring
2168,Modify the molecule CCn1cc[nH+]c1[C@@H]1CCCN(C(=O)CSCC[NH+]2CCCC2)C1 by removing a amide.,CCn1cc[nH+]c1[C@@H]1CCCN(C(=O)CSCC[NH+]2CCCC2)C1,amide
235393,Please remove a amine from the molecule CC[NH+]1CCC[C@H]1CNC(=O)c1sc2ncnc(NCc3ccc4c(c3)OCO4)c2c1C.,CC[NH+]1CCC[C@H]1CNC(=O)c1sc2ncnc(NCc3ccc4c(c3)OCO4)c2c1C,amine
244950,Please remove a amide from the molecule C[C@H](NC(=O)c1cccs1)C(=O)N1CCc2c(sc(N)c2C#N)C1.,C[C@H](NC(=O)c1cccs1)C(=O)N1CCc2c(sc(N)c2C#N)C1,amide
125572,Modify the molecule O[C@]12CCCC[C@H]1[C@@H](Cc1cccnc1Cl)[NH2+]CC2 by removing a hydroxyl.,O[C@]12CCCC[C@H]1[C@@H](Cc1cccnc1Cl)[NH2+]CC2,hydroxyl
220551,Remove a amide from the molecule CCc1ccccc1OCC(=O)NCc1cscn1.,CCc1ccccc1OCC(=O)NCc1cscn1,amide
129812,Please remove a amide from the molecule CCCN(C(=O)Cn1ncc2c(=O)oc3ccccc3c21)c1ccc(OCC)cc1.,CCCN(C(=O)Cn1ncc2c(=O)oc3ccccc3c21)c1ccc(OCC)cc1,amide
52166,Modify the molecule COC(=O)c1ccc(NC(=O)Cn2ncc3c([nH]c4ccccc43)c2=O)cc1 by removing a benzene_ring.,COC(=O)c1ccc(NC(=O)Cn2ncc3c([nH]c4ccccc43)c2=O)cc1,benzene_ring
32235,Please remove a benzene_ring from the molecule CN(C)C(=O)Oc1ccc(C2CCCCC2)cc1.,CN(C)C(=O)Oc1ccc(C2CCCCC2)cc1,benzene_ring
11662,Modify the molecule COc1ccc(O[C@H](C)C(=O)Nc2ccnn2Cc2ccc(C)cc2)cc1 by removing a benzene_ring.,COc1ccc(O[C@H](C)C(=O)Nc2ccnn2Cc2ccc(C)cc2)cc1,benzene_ring
235827,Modify the molecule CCN(CC)C(=O)Cn1c(CNC(=O)c2ccccc2F)nc2ccccc21 by removing a halo.,CCN(CC)C(=O)Cn1c(CNC(=O)c2ccccc2F)nc2ccccc21,halo
15997,Modify the molecule COC(=O)CNC(=O)c1ccc(OCc2ccccc2C#N)cc1 by removing a amide.,COC(=O)CNC(=O)c1ccc(OCc2ccccc2C#N)cc1,amide
246361,Please remove a hydroxyl from the molecule Oc1ccc(O)c(C[NH2+]C2CCCCC2)c1.,Oc1ccc(O)c(C[NH2+]C2CCCCC2)c1,hydroxyl
174155,Modify the molecule COc1ccc(Oc2cc(CNC(=O)Nc3ccccc3)ccn2)cc1 by removing a benzene_ring.,COc1ccc(Oc2cc(CNC(=O)Nc3ccccc3)ccn2)cc1,benzene_ring
67636,Please remove a amine from the molecule O=S(=O)(NCC[C@H]1C[C@@H]2CC[C@H]1C2)N1CCOCC1.,O=S(=O)(NCC[C@H]1C[C@@H]2CC[C@H]1C2)N1CCOCC1,amine
16359,Remove a amide from the molecule O=C(Nc1cc([N+](=O)[O-])ccc1F)[C@@H]1CCCN1C(=O)OCC(F)(F)F.,O=C(Nc1cc([N+](=O)[O-])ccc1F)[C@@H]1CCCN1C(=O)OCC(F)(F)F,amide
68665,Please remove a amide from the molecule Cc1c(C(=O)N[C@@H]2CC[C@@H]([NH+](C)C)C2)cnc2c1c(=O)n(C)c(=O)n2C.,Cc1c(C(=O)N[C@@H]2CC[C@@H]([NH+](C)C)C2)cnc2c1c(=O)n(C)c(=O)n2C,amide
70275,Modify the molecule CC(C)[C@H](C)NC(=O)CSc1nnc(C2CC2)n1C1CC1 by removing a amide.,CC(C)[C@H](C)NC(=O)CSc1nnc(C2CC2)n1C1CC1,amide
25414,Remove a amine from the molecule COc1cc([C@@H]2C3=C(C[C@H](c4ccccc4)CC3=O)Nc3ccc4ncccc4c32)ccc1OC(C)=O.,COc1cc([C@@H]2C3=C(C[C@H](c4ccccc4)CC3=O)Nc3ccc4ncccc4c32)ccc1OC(C)=O,amine
32958,Modify the molecule Cc1nc(CC(=O)N2CCC3(CC2)CC(=O)N(C[C@H]2CCCO2)C3)cs1 by removing a amide.,Cc1nc(CC(=O)N2CCC3(CC2)CC(=O)N(C[C@H]2CCCO2)C3)cs1,amide
214024,Please remove a benzene_ring from the molecule Cc1cccc(C2=CCN(C(=O)[C@H]3CC(=O)Nc4ccccc43)CC2)c1.,Cc1cccc(C2=CCN(C(=O)[C@H]3CC(=O)Nc4ccccc43)CC2)c1,benzene_ring
191280,Please remove a benzene_ring from the molecule C=CC1CC[NH+](Cc2ccccc2OCCOC)CC1.,C=CC1CC[NH+](Cc2ccccc2OCCOC)CC1,benzene_ring
36372,Remove a amine from the molecule C[C@H]1[C@@H](C(=O)[O-])CC[NH+]1CC(=O)NNc1ccccn1.,C[C@H]1[C@@H](C(=O)[O-])CC[NH+]1CC(=O)NNc1ccccn1,amine
150302,Modify the molecule Oc1cccc(CC2(c3ccccc3)C[NH2+]C2)c1 by removing a hydroxyl.,Oc1cccc(CC2(c3ccccc3)C[NH2+]C2)c1,hydroxyl
40919,Please remove a amine from the molecule CCNC(=O)CN(CC)c1ncncc1N.,CCNC(=O)CN(CC)c1ncncc1N,amine
203128,Please remove a amine from the molecule C[C@@H](C(N)=S)N(C)C(=O)[C@H]1CCO[C@@H]1C.,C[C@@H](C(N)=S)N(C)C(=O)[C@H]1CCO[C@@H]1C,amine
225077,Modify the molecule Cc1nn(C)c(C)c1C[NH2+]CC(=O)NC1CC1 by removing a amide.,Cc1nn(C)c(C)c1C[NH2+]CC(=O)NC1CC1,amide
229325,Please remove a halo from the molecule CCCn1cc[nH+]c1Cc1cc(Cl)ncn1.,CCCn1cc[nH+]c1Cc1cc(Cl)ncn1,halo
149555,Remove a halo from the molecule O=C(Cn1ccc2ccc(F)cc21)N1CCN(CCc2ccccn2)CC1.,O=C(Cn1ccc2ccc(F)cc21)N1CCN(CCc2ccccn2)CC1,halo
48408,Remove a amine from the molecule C[NH+]1CC[C@H](NCc2ccccc2F)[C@H](c2ccccc2)C1.,C[NH+]1CC[C@H](NCc2ccccc2F)[C@H](c2ccccc2)C1,amine
77273,Remove a amide from the molecule CN(C(=O)c1cc(=O)[nH]c2ccc(S(=O)(=O)[N-]c3ccc(F)cc3)cc12)[C@H]1CCS(=O)(=O)C1.,CN(C(=O)c1cc(=O)[nH]c2ccc(S(=O)(=O)[N-]c3ccc(F)cc3)cc12)[C@H]1CCS(=O)(=O)C1,amide
189406,Remove a halo from the molecule C[C@H](Oc1ccc(Br)cc1)C(=O)N[C@H](C)c1ccc(-n2ccnc2)cc1.,C[C@H](Oc1ccc(Br)cc1)C(=O)N[C@H](C)c1ccc(-n2ccnc2)cc1,halo
116799,Please remove a benzene_ring from the molecule C[C@H]1CCC[C@@H](OC(=O)c2cccc(C(F)(F)F)c2F)C1.,C[C@H]1CCC[C@@H](OC(=O)c2cccc(C(F)(F)F)c2F)C1,benzene_ring
79534,Modify the molecule COc1ccc(C)cc1[C@@H](C)NC(=O)N1CC[NH+](CC(C)C)CC1 by removing a benzene_ring.,COc1ccc(C)cc1[C@@H](C)NC(=O)N1CC[NH+](CC(C)C)CC1,benzene_ring
162172,Modify the molecule O=C([C@H]1CC=CCC1)N1CCC([C@@]2(c3cccnc3)NC(=O)N(CCc3cccs3)C2=O)CC1 by removing a amide.,O=C([C@H]1CC=CCC1)N1CCC([C@@]2(c3cccnc3)NC(=O)N(CCc3cccs3)C2=O)CC1,amide
177055,Modify the molecule Cc1nc(C(=O)N(C)[C@@H](C)C2CC2)nn1-c1c(Cl)cccc1Cl by removing a halo.,Cc1nc(C(=O)N(C)[C@@H](C)C2CC2)nn1-c1c(Cl)cccc1Cl,halo
225734,Please remove a benzene_ring from the molecule O=C([O-])[C@H](c1c[nH]c2cc(F)ccc12)[NH+]1CCN(c2ccccc2)CC1.,O=C([O-])[C@H](c1c[nH]c2cc(F)ccc12)[NH+]1CCN(c2ccccc2)CC1,benzene_ring
166513,Remove a amine from the molecule CCCN[C@@H](c1ccc[nH+]c1N)[C@H]1C[NH+]2CCN1CC2.,CCCN[C@@H](c1ccc[nH+]c1N)[C@H]1C[NH+]2CCN1CC2,amine
16221,Please remove a benzene_ring from the molecule O=C(C1CC1)N1CCC[C@H](CNc2ncc3c(n2)CCN3c2ccccc2)C1.,O=C(C1CC1)N1CCC[C@H](CNc2ncc3c(n2)CCN3c2ccccc2)C1,benzene_ring
74762,Please remove a benzene_ring from the molecule C[C@H](c1ccccc1)n1c([C@H]2CC(=O)N(C3CCCC3)C2)nc2ccccc21.,C[C@H](c1ccccc1)n1c([C@H]2CC(=O)N(C3CCCC3)C2)nc2ccccc21,benzene_ring
182195,Modify the molecule O=[N+]([O-])c1ccccc1-n1nc(Br)nc1Br by removing a halo.,O=[N+]([O-])c1ccccc1-n1nc(Br)nc1Br,halo
247636,Remove a amide from the molecule CC(C)CC[S@@](=O)[C@@H](C)C(=O)Nc1cc(Cl)ccc1F.,CC(C)CC[S@@](=O)[C@@H](C)C(=O)Nc1cc(Cl)ccc1F,amide
221522,Please remove a amide from the molecule CCOC(=O)c1c(NC(=O)c2cc(C)no2)sc2c1CC[NH+](C(C)C)C2.,CCOC(=O)c1c(NC(=O)c2cc(C)no2)sc2c1CC[NH+](C(C)C)C2,amide
164802,Modify the molecule COC(=O)[C@@]1(NC(=O)CCc2ncc(-c3ccccc3)o2)CCOC1 by removing a benzene_ring.,COC(=O)[C@@]1(NC(=O)CCc2ncc(-c3ccccc3)o2)CCOC1,benzene_ring
50392,Please remove a halo from the molecule C[C@@H]1CCCN(C(=O)Nc2cc(Br)c(=O)n(C)c2)[C@H]1CO.,C[C@@H]1CCCN(C(=O)Nc2cc(Br)c(=O)n(C)c2)[C@H]1CO,halo
54617,Remove a amide from the molecule CCCn1/c(=N/C(=O)C[C@H]2CCCCN2C(C)=O)[nH]c2ccccc21.,CCCn1/c(=N/C(=O)C[C@H]2CCCCN2C(C)=O)[nH]c2ccccc21,amide
114778,Modify the molecule CN(C(=O)c1cc(=O)[nH]c2ccc(Br)cc12)c1ccccc1 by removing a halo.,CN(C(=O)c1cc(=O)[nH]c2ccc(Br)cc12)c1ccccc1,halo
234885,Remove a amide from the molecule Cc1noc(C)c1C[NH2+][C@@H](C)C(=O)NC1CCCC1.,Cc1noc(C)c1C[NH2+][C@@H](C)C(=O)NC1CCCC1,amide
205386,Remove a halo from the molecule Cc1cnc(Nc2ccc(NC[C@H]3CCCO3)c(F)c2)c([N+](=O)[O-])c1.,Cc1cnc(Nc2ccc(NC[C@H]3CCCO3)c(F)c2)c([N+](=O)[O-])c1,halo
64535,Modify the molecule Cc1cc(N(C)C[C@@H](O)COc2ccccc2C(F)(F)F)n2ncnc2n1 by removing a halo.,Cc1cc(N(C)C[C@@H](O)COc2ccccc2C(F)(F)F)n2ncnc2n1,halo
154081,Please remove a amide from the molecule COc1ccc(Cl)cc1N1C(=O)CS[C@@H]1c1ccccc1F.,COc1ccc(Cl)cc1N1C(=O)CS[C@@H]1c1ccccc1F,amide
205071,Modify the molecule CN(C)c1c(Cl)cccc1NC(=O)c1cc(F)c(F)cc1[N+](=O)[O-] by removing a nitro.,CN(C)c1c(Cl)cccc1NC(=O)c1cc(F)c(F)cc1[N+](=O)[O-],nitro
80869,Modify the molecule CC(=O)NC1CCN(C(=O)N[C@@H](c2ccccn2)C(C)C)CC1 by removing a amide.,CC(=O)NC1CCN(C(=O)N[C@@H](c2ccccn2)C(C)C)CC1,amide
202846,Modify the molecule CCCC(=O)Nc1cccc(NC(=O)N(CC)C[C@H](C)C#N)c1 by removing a nitrile.,CCCC(=O)Nc1cccc(NC(=O)N(CC)C[C@H](C)C#N)c1,nitrile
187905,Remove a halo from the molecule CCCC[C@H](CC)C(=O)Nc1ccccc1F.,CCCC[C@H](CC)C(=O)Nc1ccccc1F,halo
156112,Please remove a halo from the molecule Cc1oc(-c2ccc(Cl)cc2)nc1C[NH+]1CCC[C@@H](C(=O)NC2CC2)C1.,Cc1oc(-c2ccc(Cl)cc2)nc1C[NH+]1CCC[C@@H](C(=O)NC2CC2)C1,halo
113654,Modify the molecule Cc1cc(C)c(C(=O)Nc2ccc3c(c2)CCCN3C)c(=O)[nH]1 by removing a amide.,Cc1cc(C)c(C(=O)Nc2ccc3c(c2)CCCN3C)c(=O)[nH]1,amide
46721,Remove a amide from the molecule CC(C)CCC(=O)NNC(=O)N1CC[C@H](C)C[C@@H]1C.,CC(C)CCC(=O)NNC(=O)N1CC[C@H](C)C[C@@H]1C,amide
169815,Remove a benzene_ring from the molecule CC(=O)N(C)c1ccccc1NC(=O)Cc1ccc(NC(=O)C2CC2)cc1.,CC(=O)N(C)c1ccccc1NC(=O)Cc1ccc(NC(=O)C2CC2)cc1,benzene_ring
122428,Please remove a halo from the molecule CCC[NH+](Cc1nc(Cl)ccc1Cl)C1CCC([NH3+])CC1.,CCC[NH+](Cc1nc(Cl)ccc1Cl)C1CCC([NH3+])CC1,halo
150300,Please remove a amide from the molecule CSCC(=O)NNC(=O)N[C@@H](C)Cc1c(C)noc1C.,CSCC(=O)NNC(=O)N[C@@H](C)Cc1c(C)noc1C,amide
212111,Please remove a benzene_ring from the molecule Cc1cc(NC(=O)C(=O)N[C@@H]2CCc3ccccc32)ccc1-n1cnnn1.,Cc1cc(NC(=O)C(=O)N[C@@H]2CCc3ccccc32)ccc1-n1cnnn1,benzene_ring
115825,Remove a nitrile from the molecule C[C@H](C#N)CNC(=O)C(=O)Nc1ccccc1N1CCCCCC1.,C[C@H](C#N)CNC(=O)C(=O)Nc1ccccc1N1CCCCCC1,nitrile
132772,Please remove a benzene_ring from the molecule C[C@@H](Sc1nc2sc3c(c2c(=O)n1C)CCC3)C(=O)Nc1ccc(F)c([N+](=O)[O-])c1.,C[C@@H](Sc1nc2sc3c(c2c(=O)n1C)CCC3)C(=O)Nc1ccc(F)c([N+](=O)[O-])c1,benzene_ring
128600,Modify the molecule Cc1ccn2c(=O)cc(CN(Cc3ccccc3)Cc3ccc(F)cc3)[nH+]c2c1 by removing a benzene_ring.,Cc1ccn2c(=O)cc(CN(Cc3ccccc3)Cc3ccc(F)cc3)[nH+]c2c1,benzene_ring
227766,Modify the molecule CC[C@@](C)([NH3+])C(=O)NC1CCCCC1 by removing a amide.,CC[C@@](C)([NH3+])C(=O)NC1CCCCC1,amide
184153,Modify the molecule C[NH+](CC1CCOCC1)C[C@@H]1C[C@@H]1c1ccccc1 by removing a benzene_ring.,C[NH+](CC1CCOCC1)C[C@@H]1C[C@@H]1c1ccccc1,benzene_ring
62140,Modify the molecule O=C(CCn1cncn1)N1CCC[C@H](c2[nH+]ccn2Cc2ccccc2)C1 by removing a benzene_ring.,O=C(CCn1cncn1)N1CCC[C@H](c2[nH+]ccn2Cc2ccccc2)C1,benzene_ring
161207,Remove a amide from the molecule O=C(Nc1cccc(S(=O)(=O)N2CCCC2)c1)c1cncn1-c1ccccc1.,O=C(Nc1cccc(S(=O)(=O)N2CCCC2)c1)c1cncn1-c1ccccc1,amide
85974,Remove a benzene_ring from the molecule COCc1ccccc1C(=O)NC[C@H](O)c1cccc(C(F)(F)F)c1.,COCc1ccccc1C(=O)NC[C@H](O)c1cccc(C(F)(F)F)c1,benzene_ring
54138,Remove a amide from the molecule Cc1noc(C)c1C[C@@H](C)C(=O)N[C@@H](C#N)C(C)(C)C.,Cc1noc(C)c1C[C@@H](C)C(=O)N[C@@H](C#N)C(C)(C)C,amide
186079,Remove a benzene_ring from the molecule COc1cc([N+](=O)[O-])ccc1-c1ccc(/C=N\NC(=O)c2ccccc2)o1.,COc1cc([N+](=O)[O-])ccc1-c1ccc(/C=N\NC(=O)c2ccccc2)o1,benzene_ring
159583,Remove a amine from the molecule CCCS(=O)(=O)[N-]c1ccc(S(=O)(=O)N[C@@H]2CCCC[C@H]2C)cc1F.,CCCS(=O)(=O)[N-]c1ccc(S(=O)(=O)N[C@@H]2CCCC[C@H]2C)cc1F,amine
34663,Remove a amide from the molecule C[C@H]1CCC[C@@H](N(C)C(=O)Nc2ccc(Cl)c(C(=O)NC3CC3)c2)C1.,C[C@H]1CCC[C@@H](N(C)C(=O)Nc2ccc(Cl)c(C(=O)NC3CC3)c2)C1,amide
132634,Modify the molecule CCNC(=O)Cn1cnc2cc(-c3ccc(OC)cc3)sc2c1=O by removing a amide.,CCNC(=O)Cn1cnc2cc(-c3ccc(OC)cc3)sc2c1=O,amide
185188,Modify the molecule COc1ccc2c(C)cc(SCC(=O)N[C@@H](C)c3ccccc3)nc2c1 by removing a benzene_ring.,COc1ccc2c(C)cc(SCC(=O)N[C@@H](C)c3ccccc3)nc2c1,benzene_ring
28127,Remove a halo from the molecule O=c1[nH]c(CN(CCC(F)(F)F)C2CCCC2)nc2ccccc12.,O=c1[nH]c(CN(CCC(F)(F)F)C2CCCC2)nc2ccccc12,halo
223910,Remove a nitrile from the molecule COc1ccc(-c2nc(SCC(C)C)nc([O-])c2C#N)cc1.,COc1ccc(-c2nc(SCC(C)C)nc([O-])c2C#N)cc1,nitrile
231787,Remove a halo from the molecule COC(=O)c1c(C)sc(-c2c(-c3ccc(Cl)cc3)[nH]c3nc([O-])[nH]c(=O)c23)c1O.,COC(=O)c1c(C)sc(-c2c(-c3ccc(Cl)cc3)[nH]c3nc([O-])[nH]c(=O)c23)c1O,halo
185721,Remove a amide from the molecule Cc1cc(C)n(CCNC(=O)c2ccc([C@H]3CCC[NH+]3C(C)C)s2)n1.,Cc1cc(C)n(CCNC(=O)c2ccc([C@H]3CCC[NH+]3C(C)C)s2)n1,amide
193858,Please remove a amide from the molecule CCN(CCNC(=O)[C@H]1CC(=O)N(C2CC2)C1)c1ccccc1C.,CCN(CCNC(=O)[C@H]1CC(=O)N(C2CC2)C1)c1ccccc1C,amide
171923,Modify the molecule C[C@@H](CCl)CSc1ncnc2c1CCC2 by removing a halo.,C[C@@H](CCl)CSc1ncnc2c1CCC2,halo
249351,Modify the molecule CC(=O)c1ccc(NCC(C)(C)N2CCOCC2)c([N+](=O)[O-])c1 by removing a nitro.,CC(=O)c1ccc(NCC(C)(C)N2CCOCC2)c([N+](=O)[O-])c1,nitro
121865,Modify the molecule O=C(Nc1nc2ccc(F)cc2s1)c1ccccc1[N-]S(=O)(=O)c1ccccc1 by removing a benzene_ring.,O=C(Nc1nc2ccc(F)cc2s1)c1ccccc1[N-]S(=O)(=O)c1ccccc1,benzene_ring
92168,Remove a amide from the molecule C[NH+](C)[C@@H](CNC(=O)CCc1ccc(Cl)s1)c1ccc(Cl)cc1.,C[NH+](C)[C@@H](CNC(=O)CCc1ccc(Cl)s1)c1ccc(Cl)cc1,amide
186229,Remove a benzene_ring from the molecule CNC(=O)c1ccc(OC)c(NC(=O)NCc2cccnc2)c1.,CNC(=O)c1ccc(OC)c(NC(=O)NCc2cccnc2)c1,benzene_ring
82789,Modify the molecule Cc1cc([C@@H](C)[NH2+]Cc2cnn(-c3ccc(F)cc3)c2)c(C)s1 by removing a halo.,Cc1cc([C@@H](C)[NH2+]Cc2cnn(-c3ccc(F)cc3)c2)c(C)s1,halo
124979,Modify the molecule C[C@H](Nc1ccc2c(c1)OCCCO2)C(=O)Nc1ccccc1[N+](=O)[O-] by removing a nitro.,C[C@H](Nc1ccc2c(c1)OCCCO2)C(=O)Nc1ccccc1[N+](=O)[O-],nitro
93750,Modify the molecule C[C@H]1C[C@@H]1C(=O)N1CCN(C(=O)c2cnc(Oc3ccccc3)cn2)CC1 by removing a amide.,C[C@H]1C[C@@H]1C(=O)N1CCN(C(=O)c2cnc(Oc3ccccc3)cn2)CC1,amide
76912,Remove a amide from the molecule Cc1c(C(=O)N[C@@H](C)CNc2nc3c(c(=O)[nH]2)CCCC3)oc2ccccc12.,Cc1c(C(=O)N[C@@H](C)CNc2nc3c(c(=O)[nH]2)CCCC3)oc2ccccc12,amide
90797,Modify the molecule COc1cc([C@H](C)[NH2+][C@@H]2CCOc3cc(C)c(C)cc32)ccc1F by removing a halo.,COc1cc([C@H](C)[NH2+][C@@H]2CCOc3cc(C)c(C)cc32)ccc1F,halo
101928,Please remove a amide from the molecule CC[C@@H]1CC(=O)N(C[C@H]([NH2+]C)C2CC2)C1.,CC[C@@H]1CC(=O)N(C[C@H]([NH2+]C)C2CC2)C1,amide
141314,Please remove a amine from the molecule CCc1nn(C)c(NC[C@@H]2C[C@@H]2c2ccccc2)c1[N+](=O)[O-].,CCc1nn(C)c(NC[C@@H]2C[C@@H]2c2ccccc2)c1[N+](=O)[O-],amine
232564,Remove a amide from the molecule COc1cc(/C=C/C(=O)N2CCCC[C@H]2C)cc2c1OCCO2.,COc1cc(/C=C/C(=O)N2CCCC[C@H]2C)cc2c1OCCO2,amide
126053,Modify the molecule CN(CC(C)(C)O)C(=O)c1cccc(OC(F)F)c1 by removing a benzene_ring.,CN(CC(C)(C)O)C(=O)c1cccc(OC(F)F)c1,benzene_ring
100111,Remove a amide from the molecule C[C@H](NC(=O)Cc1c(Cl)cccc1Cl)c1ccc(S(=O)(=O)N(C)C)cc1.,C[C@H](NC(=O)Cc1c(Cl)cccc1Cl)c1ccc(S(=O)(=O)N(C)C)cc1,amide
206749,Remove a amide from the molecule COc1ccc([N+](=O)[O-])cc1NC(=O)[C@H](C)SC1=NCCS1.,COc1ccc([N+](=O)[O-])cc1NC(=O)[C@H](C)SC1=NCCS1,amide
24123,Please remove a nitro from the molecule COC(=O)CCCc1nc2ccc([N+](=O)[O-])cc2s1.,COC(=O)CCCc1nc2ccc([N+](=O)[O-])cc2s1,nitro
87140,Remove a benzene_ring from the molecule Cc1nn(CC(C)C)c2sc(C(=O)N[C@H](C)c3ccccc3)cc12.,Cc1nn(CC(C)C)c2sc(C(=O)N[C@H](C)c3ccccc3)cc12,benzene_ring
54236,Remove a amide from the molecule Cc1cc([C@@H]2CCCN(C(=O)c3c[nH]c(C(C)C)n3)C2)n[nH]1.,Cc1cc([C@@H]2CCCN(C(=O)c3c[nH]c(C(C)C)n3)C2)n[nH]1,amide
211698,Please remove a amide from the molecule CCN(CC(=O)Nc1ccc2c(c1)OCCO2)C(=O)C=C1CCCCC1.,CCN(CC(=O)Nc1ccc2c(c1)OCCO2)C(=O)C=C1CCCCC1,amide
220103,Remove a amide from the molecule C=CCNC(=O)CN1CCOC[C@H]1C#N.,C=CCNC(=O)CN1CCOC[C@H]1C#N,amide
175026,Please remove a benzene_ring from the molecule CC1(C)[C@H]2CC[C@]1(C)[C@H](NC(=O)c1ccccc1)C2.,CC1(C)[C@H]2CC[C@]1(C)[C@H](NC(=O)c1ccccc1)C2,benzene_ring
211524,Remove a benzene_ring from the molecule N#Cc1ccc(C(=O)Nc2nnc(-c3ccc(Br)s3)o2)cc1.,N#Cc1ccc(C(=O)Nc2nnc(-c3ccc(Br)s3)o2)cc1,benzene_ring
41787,Remove a benzene_ring from the molecule COc1cc(OC)cc([C@H]2CCN(C(=O)[C@@H]3CCO[C@H]3C)C2)c1.,COc1cc(OC)cc([C@H]2CCN(C(=O)[C@@H]3CCO[C@H]3C)C2)c1,benzene_ring
39545,Please remove a benzene_ring from the molecule COc1ccc(-c2csc(NC(=O)NC[C@@H]3CCCO3)n2)cc1.,COc1ccc(-c2csc(NC(=O)NC[C@@H]3CCCO3)n2)cc1,benzene_ring
246440,Modify the molecule CC[C@@H](C)CN(C)C(=O)Nc1ccc(F)c(C(=O)N(C)C)c1 by removing a benzene_ring.,CC[C@@H](C)CN(C)C(=O)Nc1ccc(F)c(C(=O)N(C)C)c1,benzene_ring
230340,Remove a halo from the molecule CCCNC(=O)NCc1cc[nH+]c(N2CCN(c3ccc(F)cc3)CC2)c1.,CCCNC(=O)NCc1cc[nH+]c(N2CCN(c3ccc(F)cc3)CC2)c1,halo
60481,Please remove a amide from the molecule O=C1[C@@H](Sc2nc3ccccc3o2)CCN1c1c(F)cccc1F.,O=C1[C@@H](Sc2nc3ccccc3o2)CCN1c1c(F)cccc1F,amide
24593,Please remove a amide from the molecule N#Cc1ccc(C(=O)N2CCCS/C2=N\c2cccc(C(F)(F)F)c2)cc1.,N#Cc1ccc(C(=O)N2CCCS/C2=N\c2cccc(C(F)(F)F)c2)cc1,amide
194918,Modify the molecule CCOc1ccc2nc(N3CCC[C@@H]3C(=O)N(C)CCc3ccccn3)nc(C)c2c1 by removing a amide.,CCOc1ccc2nc(N3CCC[C@@H]3C(=O)N(C)CCc3ccccn3)nc(C)c2c1,amide
131315,Modify the molecule CC(=O)C1=C(C)[C@@H](C(=O)N2CCN(c3cccc(C)c3C)CC2)N=C1C by removing a amide.,CC(=O)C1=C(C)[C@@H](C(=O)N2CCN(c3cccc(C)c3C)CC2)N=C1C,amide
45775,Modify the molecule Cc1nc(CC(CO)(CO)Cc2ccccc2)sc1C by removing a benzene_ring.,Cc1nc(CC(CO)(CO)Cc2ccccc2)sc1C,benzene_ring
107239,Modify the molecule O=C(CSc1ncnc2ccsc12)c1cc(F)ccc1F by removing a halo.,O=C(CSc1ncnc2ccsc12)c1cc(F)ccc1F,halo
196414,Please remove a hydroxyl from the molecule CCC[NH2+][C@@]1(CO)CC[C@@H](n2c(C)nc3ccccc32)C1.,CCC[NH2+][C@@]1(CO)CC[C@@H](n2c(C)nc3ccccc32)C1,hydroxyl
227318,Remove a halo from the molecule Cc1c(Cl)cccc1S(=O)(=O)NC[C@H](c1cccs1)N(C)C.,Cc1c(Cl)cccc1S(=O)(=O)NC[C@H](c1cccs1)N(C)C,halo
213397,Remove a amide from the molecule Cc1csc(NC(=O)c2cnc([C@@H]3CCC[NH+](C)C3)cn2)n1.,Cc1csc(NC(=O)c2cnc([C@@H]3CCC[NH+](C)C3)cn2)n1,amide
165929,Remove a amine from the molecule CCc1cccc(N[C@@H]2c3ncccc3C(=O)N2c2cc(OC)ccc2OC)c1.,CCc1cccc(N[C@@H]2c3ncccc3C(=O)N2c2cc(OC)ccc2OC)c1,amine
58351,Please remove a amine from the molecule CCN[C@H](c1cc(C)cnc1N)C(C)(C)[NH+](C)C.,CCN[C@H](c1cc(C)cnc1N)C(C)(C)[NH+](C)C,amine
114805,Please remove a hydroxyl from the molecule C[C@H](NC(=O)N[C@H](C)[C@@H](C)CO)c1cccc(N2CCCC2)c1.,C[C@H](NC(=O)N[C@H](C)[C@@H](C)CO)c1cccc(N2CCCC2)c1,hydroxyl
189974,Modify the molecule CC[C@H](C)NC(=O)[C@H]1CC[C@H](c2ccccc2)N(C(C)=O)C1 by removing a benzene_ring.,CC[C@H](C)NC(=O)[C@H]1CC[C@H](c2ccccc2)N(C(C)=O)C1,benzene_ring
23455,Please remove a amide from the molecule C[C@@H](NC(=O)[C@H]1CC=CCC1)c1ccc(F)c(F)c1.,C[C@@H](NC(=O)[C@H]1CC=CCC1)c1ccc(F)c(F)c1,amide
40257,Please remove a halo from the molecule O=C(NCCc1nc2ccccc2s1)c1ccc(OCC(F)F)nc1.,O=C(NCCc1nc2ccccc2s1)c1ccc(OCC(F)F)nc1,halo
104408,Modify the molecule C[C@H]1c2ccccc2O[C@@H]1C(=O)OCc1cc(Cl)c2c(c1)OCO2 by removing a halo.,C[C@H]1c2ccccc2O[C@@H]1C(=O)OCc1cc(Cl)c2c(c1)OCO2,halo
20512,Remove a halo from the molecule Cc1ccc(NC(=O)C[n+]2ccc(Cc3ccccc3)cc2)cc1Cl.,Cc1ccc(NC(=O)C[n+]2ccc(Cc3ccccc3)cc2)cc1Cl,halo
224288,Modify the molecule CS[C@@H](C#N)C(F)(F)F by removing a halo.,CS[C@@H](C#N)C(F)(F)F,halo
66403,Modify the molecule CC(C)c1nnsc1CNC(=O)c1nc2ccccn2c1F by removing a halo.,CC(C)c1nnsc1CNC(=O)c1nc2ccccn2c1F,halo
156575,Please remove a benzene_ring from the molecule COc1ccccc1OCC[NH2+]C[C@@]1(C)CC(C)=NO1.,COc1ccccc1OCC[NH2+]C[C@@]1(C)CC(C)=NO1,benzene_ring
225543,Modify the molecule COc1cc(NC(=O)C[NH+]2CCCN(c3ncccn3)CC2)ccc1Cl by removing a halo.,COc1cc(NC(=O)C[NH+]2CCCN(c3ncccn3)CC2)ccc1Cl,halo
106946,Please remove a halo from the molecule CCOC(=O)C(F)(F)Oc1cc(C)ccc1C.,CCOC(=O)C(F)(F)Oc1cc(C)ccc1C,halo
205953,Modify the molecule Cc1cc(C)cc(CCNC(=O)N(C)[C@H](C)c2ccco2)c1 by removing a benzene_ring.,Cc1cc(C)cc(CCNC(=O)N(C)[C@H](C)c2ccco2)c1,benzene_ring
104685,Remove a amine from the molecule Cn1cc[nH+]c1[C@@H](NCC(C)(C)S(C)(=O)=O)c1cccs1.,Cn1cc[nH+]c1[C@@H](NCC(C)(C)S(C)(=O)=O)c1cccs1,amine
225419,Remove a amine from the molecule Nc1ccc(COCc2ccccc2)c2ncccc12.,Nc1ccc(COCc2ccccc2)c2ncccc12,amine
194300,Remove a amine from the molecule Cn1cnnc1CCn1nnnc1N.,Cn1cnnc1CCn1nnnc1N,amine
180209,Please remove a amide from the molecule Cc1ccc(NC(=O)c2[nH]nc([N+](=O)[O-])c2Br)c(C)c1.,Cc1ccc(NC(=O)c2[nH]nc([N+](=O)[O-])c2Br)c(C)c1,amide
191905,Modify the molecule C[NH2+]C[C@H](C)C(=O)N1CC[C@H](C)[C@H]2CCCC[C@@H]21 by removing a amide.,C[NH2+]C[C@H](C)C(=O)N1CC[C@H](C)[C@H]2CCCC[C@@H]21,amide
233001,Please remove a benzene_ring from the molecule COc1ccc(CN2CC[NH+](C)[C@@]3(CCNC(=O)CC3)C2)cc1Cn1cccn1.,COc1ccc(CN2CC[NH+](C)[C@@]3(CCNC(=O)CC3)C2)cc1Cn1cccn1,benzene_ring
23943,Modify the molecule CN(Cc1ccc2c(c1)OCO2)C(=O)c1ccc2ccc(Cl)cc2n1 by removing a halo.,CN(Cc1ccc2c(c1)OCO2)C(=O)c1ccc2ccc(Cl)cc2n1,halo
236121,Please remove a benzene_ring from the molecule CCOc1ccc(-n2c(-c3ccccc3)c(CC)n3c4c(=O)n(C)c(=O)n(C)c4nc23)cc1.,CCOc1ccc(-n2c(-c3ccccc3)c(CC)n3c4c(=O)n(C)c(=O)n(C)c4nc23)cc1,benzene_ring
20725,Remove a nitrile from the molecule C[C@@H](c1ccccc1)[NH+](C)CCOc1ccc(C#N)cc1.,C[C@@H](c1ccccc1)[NH+](C)CCOc1ccc(C#N)cc1,nitrile
166022,Please remove a benzene_ring from the molecule Cc1ccc(Br)cc1S(=O)(=O)N1CCC[C@H](N2CCCC2=O)C1.,Cc1ccc(Br)cc1S(=O)(=O)N1CCC[C@H](N2CCCC2=O)C1,benzene_ring
200076,Modify the molecule O=C(Nc1ccc(N2CCOCC2)cc1C(F)(F)F)NC1CCCCCC1 by removing a benzene_ring.,O=C(Nc1ccc(N2CCOCC2)cc1C(F)(F)F)NC1CCCCCC1,benzene_ring
113041,Please remove a amine from the molecule C[C@H]1C[C@@H]([NH3+])CN(Cc2nc(N)nc(N(C)C)n2)C1.,C[C@H]1C[C@@H]([NH3+])CN(Cc2nc(N)nc(N(C)C)n2)C1,amine
231004,Modify the molecule Cc1nc(N2CCC[C@@H]2C(=O)NCCC2=CC[C@@H]3C[C@H]2C3(C)C)nc2cc(S(C)(=O)=O)ccc12 by removing a amide.,Cc1nc(N2CCC[C@@H]2C(=O)NCCC2=CC[C@@H]3C[C@H]2C3(C)C)nc2cc(S(C)(=O)=O)ccc12,amide
79413,Please remove a amide from the molecule CNC(=O)[C@@H](C)n1c2ccccc2c2cn[nH]c(=O)c21.,CNC(=O)[C@@H](C)n1c2ccccc2c2cn[nH]c(=O)c21,amide
50476,Modify the molecule C[C@@H]1C[NH+](Cc2c[nH]nc2-c2ccc(F)cc2)CC[C@@]1(O)C1CCOCC1 by removing a hydroxyl.,C[C@@H]1C[NH+](Cc2c[nH]nc2-c2ccc(F)cc2)CC[C@@]1(O)C1CCOCC1,hydroxyl
57261,Modify the molecule CCOC[C@H]1CCN(C(=O)N[C@@H](C)c2ccc(-n3cncn3)cc2)C1 by removing a benzene_ring.,CCOC[C@H]1CCN(C(=O)N[C@@H](C)c2ccc(-n3cncn3)cc2)C1,benzene_ring
60135,Modify the molecule CCn1nc(C)c(C[NH2+]Cc2cn(-c3ccc(F)cc3F)nc2-c2ccccc2C)c1C by removing a benzene_ring.,CCn1nc(C)c(C[NH2+]Cc2cn(-c3ccc(F)cc3F)nc2-c2ccccc2C)c1C,benzene_ring
202632,Remove a amide from the molecule C#Cc1cccc(NC(=O)C(=O)NC2CCN(C(=O)c3ccco3)CC2)c1.,C#Cc1cccc(NC(=O)C(=O)NC2CCN(C(=O)c3ccco3)CC2)c1,amide
99742,Please remove a amide from the molecule COc1cc2c(cc1OC)CCN(C(=O)c1cnn(C)c1C)CC2.,COc1cc2c(cc1OC)CCN(C(=O)c1cnn(C)c1C)CC2,amide
154577,Modify the molecule C=C(C)CN(CC)C(=O)CN1CCN(C(=O)C[NH+](C)C)CC1 by removing a amide.,C=C(C)CN(CC)C(=O)CN1CCN(C(=O)C[NH+](C)C)CC1,amide
223290,Please remove a amide from the molecule Cc1ccc(N2CCOC2=O)cc1NC(=O)[C@H](C)Sc1ccccc1.,Cc1ccc(N2CCOC2=O)cc1NC(=O)[C@H](C)Sc1ccccc1,amide
71599,Remove a amine from the molecule C[C@@H]1CN(C(=O)c2cn[nH]c2N)C[C@H]1C.,C[C@@H]1CN(C(=O)c2cn[nH]c2N)C[C@H]1C,amine
54086,Remove a nitrile from the molecule CCOC(=O)C[C@H](C)Nc1snc(Cl)c1C#N.,CCOC(=O)C[C@H](C)Nc1snc(Cl)c1C#N,nitrile
23755,Remove a amide from the molecule CCc1ccc(-c2nc(CC(=O)Nc3nc(C)c(C)s3)cs2)cc1.,CCc1ccc(-c2nc(CC(=O)Nc3nc(C)c(C)s3)cs2)cc1,amide
201362,Remove a amide from the molecule N#Cc1cn(C2CC2)c(=O)n(CC(=O)N2CCN(C(=O)c3ccco3)CC2)c1=O.,N#Cc1cn(C2CC2)c(=O)n(CC(=O)N2CCN(C(=O)c3ccco3)CC2)c1=O,amide
112618,Modify the molecule Cc1cccc([S@@](=O)CCC(=O)Nc2cc(F)cc(F)c2)c1 by removing a amide.,Cc1cccc([S@@](=O)CCC(=O)Nc2cc(F)cc(F)c2)c1,amide
243204,Please remove a halo from the molecule Cc1ccc(-n2nc(C)c(CC(=O)Oc3ccc(C(N)=O)cc3)c2C)cc1Cl.,Cc1ccc(-n2nc(C)c(CC(=O)Oc3ccc(C(N)=O)cc3)c2C)cc1Cl,halo
184141,Please remove a amide from the molecule C[C@H]1Nc2ccccc2C[C@@H]1C(=O)N[C@@H]1CCCC1(C)C.,C[C@H]1Nc2ccccc2C[C@@H]1C(=O)N[C@@H]1CCCC1(C)C,amide
93208,Please remove a amide from the molecule CCOC(=O)c1ccc(NC(=O)c2oc3c(c2C)/C(=N/NC(N)=S)CCC3)cc1.,CCOC(=O)c1ccc(NC(=O)c2oc3c(c2C)/C(=N/NC(N)=S)CCC3)cc1,amide
76526,Remove a amide from the molecule Cc1ccc(CCNC(=O)CCn2cnc3onc(-c4ccc(F)cc4)c3c2=O)cc1.,Cc1ccc(CCNC(=O)CCn2cnc3onc(-c4ccc(F)cc4)c3c2=O)cc1,amide
123565,Modify the molecule COc1ccc(C2=C[C@H](C(=O)N3CCN(C(=O)c4ccco4)CC3)N=N2)cc1 by removing a amide.,COc1ccc(C2=C[C@H](C(=O)N3CCN(C(=O)c4ccco4)CC3)N=N2)cc1,amide
74755,Remove a benzene_ring from the molecule COc1ccc(COCCNC(=O)N2CC[C@@H]3CCCC[C@H]32)cc1.,COc1ccc(COCCNC(=O)N2CC[C@@H]3CCCC[C@H]32)cc1,benzene_ring
198876,Please remove a nitrile from the molecule COc1cc(OC)cc([C@@H]2CCN(Cc3ccc(F)cc3C#N)C2)c1.,COc1cc(OC)cc([C@@H]2CCN(Cc3ccc(F)cc3C#N)C2)c1,nitrile
53851,Remove a amide from the molecule CC(C)n1ccc2ccc(C(=O)NCc3nnc4ccccn34)cc21.,CC(C)n1ccc2ccc(C(=O)NCc3nnc4ccccn34)cc21,amide
9524,Remove a benzene_ring from the molecule O=C(Nc1ccccc1Oc1ccccc1)N1CCOCC1.,O=C(Nc1ccccc1Oc1ccccc1)N1CCOCC1,benzene_ring
9991,Remove a hydroxyl from the molecule Cc1cccc(-n2ncc3c(O)nc(SCC(N)=O)nc32)c1C.,Cc1cccc(-n2ncc3c(O)nc(SCC(N)=O)nc32)c1C,hydroxyl
178416,Modify the molecule C[C@H]1C[C@H]1C(=O)OCC(=O)Nc1cc(S(C)(=O)=O)ccc1Cl by removing a halo.,C[C@H]1C[C@H]1C(=O)OCC(=O)Nc1cc(S(C)(=O)=O)ccc1Cl,halo
184774,Remove a benzene_ring from the molecule CC(C)[NH2+]Cc1c[nH]nc1-c1ccc(C(C)(C)C)cc1.,CC(C)[NH2+]Cc1c[nH]nc1-c1ccc(C(C)(C)C)cc1,benzene_ring
77064,Please remove a amide from the molecule CN(CC(=O)N[C@H](C#N)C(C)(C)C)C(=O)c1ccc(Br)o1.,CN(CC(=O)N[C@H](C#N)C(C)(C)C)C(=O)c1ccc(Br)o1,amide
60216,Remove a benzene_ring from the molecule CCCc1cc(C(=O)N(C)[C@H](C)c2cc(-c3ccccc3)[nH]n2)n(C)n1.,CCCc1cc(C(=O)N(C)[C@H](C)c2cc(-c3ccccc3)[nH]n2)n(C)n1,benzene_ring
195815,Please remove a benzene_ring from the molecule Cc1noc(C)c1CCCNC(=O)N(C)Cc1c(F)cccc1Cl.,Cc1noc(C)c1CCCNC(=O)N(C)Cc1c(F)cccc1Cl,benzene_ring
168122,Remove a amide from the molecule N#Cc1cccc(/C=C/C(=O)N2CCCCC[C@@H]2c2ccncc2)c1.,N#Cc1cccc(/C=C/C(=O)N2CCCCC[C@@H]2c2ccncc2)c1,amide
123756,Please remove a amide from the molecule COc1ccc2c(c1)CCCN2C(=O)C[NH+]1CCC[C@@H]1c1ccc(OC)c(OC)c1.,COc1ccc2c(c1)CCCN2C(=O)C[NH+]1CCC[C@@H]1c1ccc(OC)c(OC)c1,amide
188854,Remove a amide from the molecule Cc1cc(C(=O)NCc2cccnc2)nc(N(C)C)n1.,Cc1cc(C(=O)NCc2cccnc2)nc(N(C)C)n1,amide
6340,Modify the molecule C[C@H](NC(=O)OCc1ccccc1)C(O)(O)C(=O)CCl by removing a halo.,C[C@H](NC(=O)OCc1ccccc1)C(O)(O)C(=O)CCl,halo
226988,Remove a benzene_ring from the molecule Cc1ccc(O[C@@H](C)C(=O)N2CCC(C(N)=O)CC2)cc1.,Cc1ccc(O[C@@H](C)C(=O)N2CCC(C(N)=O)CC2)cc1,benzene_ring
170385,Please remove a amide from the molecule CCC(CC)(CO)CNC(=O)c1ccc2c(c1)COCO2.,CCC(CC)(CO)CNC(=O)c1ccc2c(c1)COCO2,amide
239787,Please remove a amide from the molecule C[C@@H]1CCC[C@@H](NC(=O)CN2C(=O)NC3(CCC(C(C)(C)C)CC3)C2=O)[C@@H]1C.,C[C@@H]1CCC[C@@H](NC(=O)CN2C(=O)NC3(CCC(C(C)(C)C)CC3)C2=O)[C@@H]1C,amide
245506,Modify the molecule Fc1cccc(/N=C(\[S-])Nc2ccc(Br)cc2)c1 by removing a halo.,Fc1cccc(/N=C(\[S-])Nc2ccc(Br)cc2)c1,halo
30692,Remove a amide from the molecule CCN(CC)C(=O)CCC(=O)N1CCC[C@@H](C)[C@@H]1c1ccc(C)cc1.,CCN(CC)C(=O)CCC(=O)N1CCC[C@@H](C)[C@@H]1c1ccc(C)cc1,amide
156973,Remove a benzene_ring from the molecule O=[N+]([O-])c1cnn(C[C@H](CS)c2ccccc2)c1.,O=[N+]([O-])c1cnn(C[C@H](CS)c2ccccc2)c1,benzene_ring
158175,Remove a amine from the molecule CC[C@@H]1CSC(NC2CCCCCCC2)=[NH+]1.,CC[C@@H]1CSC(NC2CCCCCCC2)=[NH+]1,amine
24594,Remove a amide from the molecule O=C(CC[NH2+][C@@H]1CCOC2(CCCCC2)C1)NC1CC1.,O=C(CC[NH2+][C@@H]1CCOC2(CCCCC2)C1)NC1CC1,amide
190143,Modify the molecule C[C@@H]1CC(C)(C)CC[C@H]1NC(=O)N1CCN(C(=O)c2ccncc2)CC1 by removing a amide.,C[C@@H]1CC(C)(C)CC[C@H]1NC(=O)N1CCN(C(=O)c2ccncc2)CC1,amide
175794,Please remove a amide from the molecule CCCCCN1CC(=O)N2[C@@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc(C)cc2)C1=O.,CCCCCN1CC(=O)N2[C@@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc(C)cc2)C1=O,amide
59630,Remove a amide from the molecule CN1C(=O)NC(=O)[C@]2(Cc3ccccc3N3CCN(Cc4ccc5c(c4)OCO5)C[C@@H]32)C1=O.,CN1C(=O)NC(=O)[C@]2(Cc3ccccc3N3CCN(Cc4ccc5c(c4)OCO5)C[C@@H]32)C1=O,amide
99195,Please remove a benzene_ring from the molecule COC(=O)c1ccc(-c2csc(NC(=O)[C@@H]3CCCN3S(=O)(=O)c3ccc(C)cc3)n2)cc1.,COC(=O)c1ccc(-c2csc(NC(=O)[C@@H]3CCCN3S(=O)(=O)c3ccc(C)cc3)n2)cc1,benzene_ring
51563,Modify the molecule CCS(=O)(=O)N[C@H](C)CCc1ccccc1 by removing a amine.,CCS(=O)(=O)N[C@H](C)CCc1ccccc1,amine
194316,Remove a benzene_ring from the molecule CCOc1ccc([C@@H](C)NC(=O)Nc2ccc(NC(=O)C3CC3)cc2)cc1.,CCOc1ccc([C@@H](C)NC(=O)Nc2ccc(NC(=O)C3CC3)cc2)cc1,benzene_ring
187570,Please remove a amine from the molecule Cc1nc(CCNc2nccc(-c3cc(C(=O)[O-])ccn3)n2)cc(=O)[nH]1.,Cc1nc(CCNc2nccc(-c3cc(C(=O)[O-])ccn3)n2)cc(=O)[nH]1,amine
6862,Please remove a halo from the molecule C[C@H]1C[C@H]([NH3+])CN(S(=O)(=O)c2c(F)cc(F)cc2F)C1.,C[C@H]1C[C@H]([NH3+])CN(S(=O)(=O)c2c(F)cc(F)cc2F)C1,halo
171465,Modify the molecule Cc1ccc(NC(=O)Cn2c(=O)ncc3cc(S(=O)(=O)N4CCCC[C@@H]4C)ccc32)c(C)c1 by removing a amide.,Cc1ccc(NC(=O)Cn2c(=O)ncc3cc(S(=O)(=O)N4CCCC[C@@H]4C)ccc32)c(C)c1,amide
109380,Please remove a nitro from the molecule CC[C@H](c1ccncc1)[NH+](C)Cc1csc([N+](=O)[O-])c1.,CC[C@H](c1ccncc1)[NH+](C)Cc1csc([N+](=O)[O-])c1,nitro
207962,Modify the molecule O=c1[nH]cnc2cc(-c3ccc(Cl)cc3)sc12 by removing a halo.,O=c1[nH]cnc2cc(-c3ccc(Cl)cc3)sc12,halo
129603,Modify the molecule CCc1nnc(NC(=O)N2C[C@H](C)O[C@H](c3ccccc3)C2)s1 by removing a benzene_ring.,CCc1nnc(NC(=O)N2C[C@H](C)O[C@H](c3ccccc3)C2)s1,benzene_ring
49902,Modify the molecule COc1ccc(OC)c(NC(=O)N2CCC[C@@H](OC)C2)c1 by removing a benzene_ring.,COc1ccc(OC)c(NC(=O)N2CCC[C@@H](OC)C2)c1,benzene_ring
131995,Remove a hydroxyl from the molecule CCN(CC(C)(C)O)C(=O)Cc1nc(CCl)cs1.,CCN(CC(C)(C)O)C(=O)Cc1nc(CCl)cs1,hydroxyl
100281,Remove a amide from the molecule CS(=O)(=O)Nc1cccc(C(=O)Nc2ccc(F)cc2)c1.,CS(=O)(=O)Nc1cccc(C(=O)Nc2ccc(F)cc2)c1,amide
144065,Please remove a halo from the molecule CC(=O)N1CCC([NH+]2CC[C@H](c3nc4cc(F)ccc4o3)C2)CC1.,CC(=O)N1CCC([NH+]2CC[C@H](c3nc4cc(F)ccc4o3)C2)CC1,halo
70193,Remove a benzene_ring from the molecule CSc1nc2ccccc2c(Nc2ccc(C(C)=O)cc2)c1C#N.,CSc1nc2ccccc2c(Nc2ccc(C(C)=O)cc2)c1C#N,benzene_ring
56385,Remove a amide from the molecule Cc1cccc(NC(=O)C(=O)NCc2ccc(C[NH+](C)C)cc2)c1Cl.,Cc1cccc(NC(=O)C(=O)NCc2ccc(C[NH+](C)C)cc2)c1Cl,amide
77091,Remove a benzene_ring from the molecule COc1cccc(/C(C)=C/C(=O)Nc2cc(C(=O)NC3CC3)ccc2C)c1.,COc1cccc(/C(C)=C/C(=O)Nc2cc(C(=O)NC3CC3)ccc2C)c1,benzene_ring
47050,Please remove a benzene_ring from the molecule C[C@H]1C[C@H]1c1ccc([C@H](O)Cc2ccc(O)cc2)o1.,C[C@H]1C[C@H]1c1ccc([C@H](O)Cc2ccc(O)cc2)o1,benzene_ring
96480,Modify the molecule CC(C)N(C)C(=O)C1CCN(S(=O)(=O)c2cccnc2)CC1 by removing a amide.,CC(C)N(C)C(=O)C1CCN(S(=O)(=O)c2cccnc2)CC1,amide
236562,Remove a hydroxyl from the molecule CC(C)[C@H](Cc1ccccc1Br)[NH2+]CC1(CO)CCOCC1.,CC(C)[C@H](Cc1ccccc1Br)[NH2+]CC1(CO)CCOCC1,hydroxyl
220902,Remove a amide from the molecule CC(C)CCO[C@H]1CCCC[C@H]1NC(=O)c1cc2c([nH]c1=O)CCCC2=O.,CC(C)CCO[C@H]1CCCC[C@H]1NC(=O)c1cc2c([nH]c1=O)CCCC2=O,amide
114795,Please remove a amide from the molecule O=C(NCC1(c2ccc(Cl)cc2)CCOCC1)c1cccnc1N1CCCC1.,O=C(NCC1(c2ccc(Cl)cc2)CCOCC1)c1cccnc1N1CCCC1,amide
31060,Modify the molecule N#Cc1ccccc1COc1cccc(C=O)c1 by removing a benzene_ring.,N#Cc1ccccc1COc1cccc(C=O)c1,benzene_ring
62942,Please remove a amide from the molecule O=C(Nc1cccc(C(=O)OCC(F)(F)F)c1)c1cccnc1.,O=C(Nc1cccc(C(=O)OCC(F)(F)F)c1)c1cccnc1,amide
218776,Please remove a amide from the molecule Cc1ccc(NC(=O)C2CC2)cc1NC(=O)[C@@H](C)c1cccs1.,Cc1ccc(NC(=O)C2CC2)cc1NC(=O)[C@@H](C)c1cccs1,amide
13788,Please remove a halo from the molecule CCc1nnc(SCC(=O)Nc2c(Cl)cccc2Cl)n1-n1cccc1.,CCc1nnc(SCC(=O)Nc2c(Cl)cccc2Cl)n1-n1cccc1,halo
10883,Remove a benzene_ring from the molecule Cc1ccc(CCC(=O)N[C@@H](c2ccccc2)c2ccncc2)cc1.,Cc1ccc(CCC(=O)N[C@@H](c2ccccc2)c2ccncc2)cc1,benzene_ring
140820,Remove a hydroxyl from the molecule COc1cc(S(=O)(=O)Nc2ccccc2O)c(OC)cc1C.,COc1cc(S(=O)(=O)Nc2ccccc2O)c(OC)cc1C,hydroxyl
142414,Please remove a benzene_ring from the molecule C[C@H](CO)NC(=O)N[C@H](Cc1ccccc1)C1CC1.,C[C@H](CO)NC(=O)N[C@H](Cc1ccccc1)C1CC1,benzene_ring
99778,Please remove a amide from the molecule C[C@H]1CCC[C@H](CC[NH+]2CCNC(=O)C2)C1.,C[C@H]1CCC[C@H](CC[NH+]2CCNC(=O)C2)C1,amide
72118,Remove a benzene_ring from the molecule O=C(NC[C@H]1C[C@@]12CCc1ccccc12)N[C@@H](CO)c1ccc(Cl)cc1.,O=C(NC[C@H]1C[C@@]12CCc1ccccc12)N[C@@H](CO)c1ccc(Cl)cc1,benzene_ring
160845,Modify the molecule O=C(C=C1CCSCC1)NNC(=O)Cc1ccsc1 by removing a amide.,O=C(C=C1CCSCC1)NNC(=O)Cc1ccsc1,amide
136004,Please remove a amide from the molecule CCn1cc(C(=O)N(CCc2cccs2)Cc2cccnc2)c(=O)c2ccc(C)nc21.,CCn1cc(C(=O)N(CCc2cccs2)Cc2cccnc2)c(=O)c2ccc(C)nc21,amide
120181,Modify the molecule O=S(=O)(c1ccc(-n2ccnc2)cc1)N1CCCC1 by removing a benzene_ring.,O=S(=O)(c1ccc(-n2ccnc2)cc1)N1CCCC1,benzene_ring
9605,Please remove a benzene_ring from the molecule CCCCN(c1ccccc1)S(=O)(=O)c1cccc2nonc12.,CCCCN(c1ccccc1)S(=O)(=O)c1cccc2nonc12,benzene_ring
175587,Please remove a benzene_ring from the molecule CCC[NH2+]Cc1ccccc1N(C)C[C@@H]1CCC[NH+]1C.,CCC[NH2+]Cc1ccccc1N(C)C[C@@H]1CCC[NH+]1C,benzene_ring
218020,Remove a benzene_ring from the molecule O=C(NCCNC(=O)[C@@H]1CC(=O)N(c2cccc(Cl)c2)C1)c1ccc2[nH]ccc2c1.,O=C(NCCNC(=O)[C@@H]1CC(=O)N(c2cccc(Cl)c2)C1)c1ccc2[nH]ccc2c1,benzene_ring
221715,Please remove a amide from the molecule CNC(=O)c1cccc(S(=O)(=O)N2CC[C@@]3(CCC[NH2+]C3)C2)c1.,CNC(=O)c1cccc(S(=O)(=O)N2CC[C@@]3(CCC[NH2+]C3)C2)c1,amide
246192,Remove a amide from the molecule Cc1cc(N2CCN(C(=O)COc3cccc4ccccc34)CC2)ncn1.,Cc1cc(N2CCN(C(=O)COc3cccc4ccccc34)CC2)ncn1,amide
186989,Please remove a benzene_ring from the molecule COC(=O)c1cccc(C(=O)O[C@H]2CCC[C@H]2OC)c1.,COC(=O)c1cccc(C(=O)O[C@H]2CCC[C@H]2OC)c1,benzene_ring
166406,Please remove a amine from the molecule O=C(CNc1ccc(Cl)c(Br)c1)Nc1ccc(F)cc1.,O=C(CNc1ccc(Cl)c(Br)c1)Nc1ccc(F)cc1,amine
76524,Modify the molecule Cc1nc2cc(NC(=O)C(=O)NCCCN3CCOCC3)ccc2o1 by removing a amide.,Cc1nc2cc(NC(=O)C(=O)NCCCN3CCOCC3)ccc2o1,amide
33410,Modify the molecule CCOc1ccccc1CCC(=O)/N=c1\[nH]nc2cc(C)ccn12 by removing a benzene_ring.,CCOc1ccccc1CCC(=O)/N=c1\[nH]nc2cc(C)ccn12,benzene_ring
222482,Remove a amine from the molecule CCOC(=O)c1nc2cnc(NC)nc2n(C)c1=O.,CCOC(=O)c1nc2cnc(NC)nc2n(C)c1=O,amine
228301,Remove a benzene_ring from the molecule CC(=O)O[C@@H]1N=C(c2ccccc2F)c2cc(Cl)ccc2-n2c1cnc2C.,CC(=O)O[C@@H]1N=C(c2ccccc2F)c2cc(Cl)ccc2-n2c1cnc2C,benzene_ring
212973,Modify the molecule C[C@H](O)c1cccc(OCc2ncc(-c3ccc(F)cc3)o2)c1 by removing a halo.,C[C@H](O)c1cccc(OCc2ncc(-c3ccc(F)cc3)o2)c1,halo
203251,Please remove a halo from the molecule Cc1cc(F)cc(N[C@]2(CO)CCC[C@H](C)[C@@H]2C)c1.,Cc1cc(F)cc(N[C@]2(CO)CCC[C@H](C)[C@@H]2C)c1,halo
187260,Remove a amine from the molecule N#Cc1ccc(CN2CCN(C(=O)CCNS(=O)(=O)c3ccc(F)c(Cl)c3)CC2)cc1.,N#Cc1ccc(CN2CCN(C(=O)CCNS(=O)(=O)c3ccc(F)c(Cl)c3)CC2)cc1,amine
94184,Remove a halo from the molecule O=C(NCc1ccc(Oc2cccnc2)c(F)c1)c1cc(Cl)ccc1[N+](=O)[O-].,O=C(NCc1ccc(Oc2cccnc2)c(F)c1)c1cc(Cl)ccc1[N+](=O)[O-],halo
35481,Remove a amide from the molecule COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CC(C)(C)c1ccccc1.,COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CC(C)(C)c1ccccc1,amide
53669,Modify the molecule Cc1ccc(C(=O)N(C)C)cc1OC(=O)c1cc(F)ccc1NC(=O)[C@H]1C[C@H]1C by removing a amide.,Cc1ccc(C(=O)N(C)C)cc1OC(=O)c1cc(F)ccc1NC(=O)[C@H]1C[C@H]1C,amide
72403,Modify the molecule CCn1c2ccccc2c2cc(NC(=O)c3ccnc(-n4cncn4)c3)ccc21 by removing a amide.,CCn1c2ccccc2c2cc(NC(=O)c3ccnc(-n4cncn4)c3)ccc21,amide
122904,Please remove a amine from the molecule CCc1ccc(S(=O)(=O)N[C@H](C(=O)[O-])C(C)C)cc1.,CCc1ccc(S(=O)(=O)N[C@H](C(=O)[O-])C(C)C)cc1,amine
125723,Modify the molecule O=C(N/N=C/c1cccs1)c1cccc(NC(=O)c2ccc(Cl)cc2)c1 by removing a halo.,O=C(N/N=C/c1cccs1)c1cccc(NC(=O)c2ccc(Cl)cc2)c1,halo
28732,Please remove a benzene_ring from the molecule CC(=O)N[C@@H](CC(=O)N1CCCCCC1)c1ccc(Br)cc1.,CC(=O)N[C@@H](CC(=O)N1CCCCCC1)c1ccc(Br)cc1,benzene_ring
129099,Remove a amine from the molecule COc1ncccc1CNCCC[NH+]1CCCC[C@H]1C.,COc1ncccc1CNCCC[NH+]1CCCC[C@H]1C,amine
239491,Modify the molecule Cc1cc(C)c(CSc2nnc(-c3ccccc3)n2N)c(C)c1 by removing a benzene_ring.,Cc1cc(C)c(CSc2nnc(-c3ccccc3)n2N)c(C)c1,benzene_ring
55537,Remove a benzene_ring from the molecule CCNC(=O)Nc1ccc(OCC(=O)NCc2cc(F)ccc2F)nc1.,CCNC(=O)Nc1ccc(OCC(=O)NCc2cc(F)ccc2F)nc1,benzene_ring
154215,Modify the molecule CSc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1 by removing a amide.,CSc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1,amide
188425,Remove a halo from the molecule COc1ccc([C@H](C)NC(=O)c2ccc(NC(=O)C3CC3)s2)cc1F.,COc1ccc([C@H](C)NC(=O)c2ccc(NC(=O)C3CC3)s2)cc1F,halo
223158,Modify the molecule CC1CCN(C(=O)c2cc3c(-c4ccc(Cl)cc4)nn(C)c3s2)CC1 by removing a benzene_ring.,CC1CCN(C(=O)c2cc3c(-c4ccc(Cl)cc4)nn(C)c3s2)CC1,benzene_ring
194165,Modify the molecule O=C(CCCNC(=O)N1CC[C@@H](C(=O)[O-])C1)NC1CC1 by removing a amide.,O=C(CCCNC(=O)N1CC[C@@H](C(=O)[O-])C1)NC1CC1,amide
171785,Modify the molecule COc1ccc(-c2nn(-c3ccccc3C)cc2C[NH+](C)Cc2nccn2C)cc1F by removing a benzene_ring.,COc1ccc(-c2nn(-c3ccccc3C)cc2C[NH+](C)Cc2nccn2C)cc1F,benzene_ring
63279,Modify the molecule CC1=N[C@H]2C(C(=O)N3CCC(N4c5[nH+]cccc5N[C@@H]4C4CCC4)CC3)=CC=CC2=C1C by removing a amide.,CC1=N[C@H]2C(C(=O)N3CCC(N4c5[nH+]cccc5N[C@@H]4C4CCC4)CC3)=CC=CC2=C1C,amide
220667,Please remove a amine from the molecule C[C@@](O)(CO)CNc1ncc(Cl)cc1F.,C[C@@](O)(CO)CNc1ncc(Cl)cc1F,amine
187659,Please remove a benzene_ring from the molecule COC(=O)C1(NC(=O)[C@@H](C)Oc2ccc(C)cc2)CCCC1.,COC(=O)C1(NC(=O)[C@@H](C)Oc2ccc(C)cc2)CCCC1,benzene_ring
186332,Modify the molecule O[C@H]1CCC[C@@H]1C[C@@H]1CCCCO1 by removing a hydroxyl.,O[C@H]1CCC[C@@H]1C[C@@H]1CCCCO1,hydroxyl
23306,Please remove a benzene_ring from the molecule CCn1cc(C(=O)N2CCN(C(=O)CCC3CCCCC3)CC2)c2nn(-c3ccccc3)c(=O)c-2c1.,CCn1cc(C(=O)N2CCN(C(=O)CCC3CCCCC3)CC2)c2nn(-c3ccccc3)c(=O)c-2c1,benzene_ring
243403,Remove a benzene_ring from the molecule COC(=O)Cc1ccccc1NC(=O)C[C@H]1CCOc2ccccc21.,COC(=O)Cc1ccccc1NC(=O)C[C@H]1CCOc2ccccc21,benzene_ring
198574,Modify the molecule C[C@]1([C@@H](Br)c2ccc(Cl)cc2Cl)CCCO1 by removing a benzene_ring.,C[C@]1([C@@H](Br)c2ccc(Cl)cc2Cl)CCCO1,benzene_ring
66322,Modify the molecule Cc1cc(N[C@@H](C)C(=O)NCc2ccccc2)nc(-c2ccncc2)n1 by removing a benzene_ring.,Cc1cc(N[C@@H](C)C(=O)NCc2ccccc2)nc(-c2ccncc2)n1,benzene_ring
20837,Please remove a hydroxyl from the molecule CC[C@](C)([C@@H](O)Cc1ccc(F)cc1Cl)N1CCOCC1.,CC[C@](C)([C@@H](O)Cc1ccc(F)cc1Cl)N1CCOCC1,hydroxyl
104450,Please remove a benzene_ring from the molecule Cc1cc(C)cc([C@H](O)C[NH2+]C2(C(N)=O)CCCCC2)c1.,Cc1cc(C)cc([C@H](O)C[NH2+]C2(C(N)=O)CCCCC2)c1,benzene_ring
86042,Remove a benzene_ring from the molecule Cc1ccc([C@@H](C)NC(=O)C(=O)Nc2cccc(-c3nccs3)c2)o1.,Cc1ccc([C@@H](C)NC(=O)C(=O)Nc2cccc(-c3nccs3)c2)o1,benzene_ring
84208,Please remove a halo from the molecule C[C@@H](OC(=O)c1cnn2cc(Br)cnc12)c1cccnc1.,C[C@@H](OC(=O)c1cnn2cc(Br)cnc12)c1cccnc1,halo
42866,Modify the molecule COCCN(Cc1ccsc1)S(=O)(=O)c1ccc(F)cc1F by removing a benzene_ring.,COCCN(Cc1ccsc1)S(=O)(=O)c1ccc(F)cc1F,benzene_ring
160700,Remove a amide from the molecule Cc1c(CNC(=O)c2occc2Br)oc2ccccc12.,Cc1c(CNC(=O)c2occc2Br)oc2ccccc12,amide
152682,Modify the molecule O=C1Nc2ccccc2/C1=C/c1cccc(C(=O)[O-])c1 by removing a amide.,O=C1Nc2ccccc2/C1=C/c1cccc(C(=O)[O-])c1,amide
43700,Modify the molecule Cc1noc(C)c1S(=O)(=O)N(C)CC(=O)N1CCCCCCC1 by removing a amide.,Cc1noc(C)c1S(=O)(=O)N(C)CC(=O)N1CCCCCCC1,amide
112433,Modify the molecule Cc1ccccc1/C=C1\Oc2c(ccc(O)c2CN2CCN(c3ccccc3)CC2)C1=O by removing a hydroxyl.,Cc1ccccc1/C=C1\Oc2c(ccc(O)c2CN2CCN(c3ccccc3)CC2)C1=O,hydroxyl
60656,Modify the molecule CSc1ccc2c(c1)CC[NH+]([C@@H]1c3ccccc3C3(CC[NH2+]CC3)[C@H]1O)C2 by removing a hydroxyl.,CSc1ccc2c(c1)CC[NH+]([C@@H]1c3ccccc3C3(CC[NH2+]CC3)[C@H]1O)C2,hydroxyl
49935,Modify the molecule Cn1c(=O)ccn(CC(=O)NCCc2ccc3c(c2)OCCO3)c1=O by removing a amide.,Cn1c(=O)ccn(CC(=O)NCCc2ccc3c(c2)OCCO3)c1=O,amide
23441,Remove a benzene_ring from the molecule C[C@H](c1ccc(Cl)cc1)N(C)c1cncc(C[NH3+])n1.,C[C@H](c1ccc(Cl)cc1)N(C)c1cncc(C[NH3+])n1,benzene_ring
35973,Modify the molecule CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1Cc1ccc(F)cc1F by removing a halo.,CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1Cc1ccc(F)cc1F,halo
149616,Modify the molecule COC(=O)C[C@@H]1CCN(C(=O)Nc2cccc([N-]S(C)(=O)=O)c2)C1 by removing a benzene_ring.,COC(=O)C[C@@H]1CCN(C(=O)Nc2cccc([N-]S(C)(=O)=O)c2)C1,benzene_ring
182159,Modify the molecule O=C(CCl)c1ncc(Cl)cc1F by removing a halo.,O=C(CCl)c1ncc(Cl)cc1F,halo
30855,Remove a amide from the molecule Cc1cc2cc(C(=O)NNC(=O)c3ccc(Cl)nc3)oc2cc1C.,Cc1cc2cc(C(=O)NNC(=O)c3ccc(Cl)nc3)oc2cc1C,amide
200853,Remove a amide from the molecule COc1ccc2c(c1)CCC[C@@H]2CC(=O)N1CCN([C@H](C#N)C(C)C)CC1.,COc1ccc2c(c1)CCC[C@@H]2CC(=O)N1CCN([C@H](C#N)C(C)C)CC1,amide
97209,Please remove a benzene_ring from the molecule O=C(c1cccc2c1OCC2)N1CCC(c2[nH]ncc2-c2ccccc2)CC1.,O=C(c1cccc2c1OCC2)N1CCC(c2[nH]ncc2-c2ccccc2)CC1,benzene_ring
180005,Remove a amide from the molecule C[C@@H]1CCC[C@H](NC(=O)C[NH+](CC(=O)N2CCCC2)C[C@@H]2CCCO2)[C@@H]1C.,C[C@@H]1CCC[C@H](NC(=O)C[NH+](CC(=O)N2CCCC2)C[C@@H]2CCCO2)[C@@H]1C,amide
213873,Remove a nitrile from the molecule CC(C)CN(C)C(=O)N[C@H]1CCCN(c2ccc(C#N)cc2F)C1.,CC(C)CN(C)C(=O)N[C@H]1CCCN(c2ccc(C#N)cc2F)C1,nitrile
224218,Modify the molecule Cc1c(C)n2c3c(=O)n(C)c(=O)n(C)c3nc2n1CC(=O)c1ccc(F)cc1 by removing a halo.,Cc1c(C)n2c3c(=O)n(C)c(=O)n(C)c3nc2n1CC(=O)c1ccc(F)cc1,halo
127995,Please remove a amide from the molecule C=CCNC(=O)NC(=O)CN1CCOC[C@@H]1C1CC1.,C=CCNC(=O)NC(=O)CN1CCOC[C@@H]1C1CC1,amide
234613,Please remove a amide from the molecule C[C@H](c1ccccc1)[NH+]1CC[C@H](NC(=O)c2ccc(Br)o2)C1.,C[C@H](c1ccccc1)[NH+]1CC[C@H](NC(=O)c2ccc(Br)o2)C1,amide
223244,Remove a amide from the molecule Cn1cc[nH+]c1[C@@H]1[C@@H](C(=O)[O-])CC(=O)N1CCc1ccccc1F.,Cn1cc[nH+]c1[C@@H]1[C@@H](C(=O)[O-])CC(=O)N1CCc1ccccc1F,amide
55426,Modify the molecule Cc1cccc(C)c1NC(=O)[C@H](C)Sc1nc2ccccc2c(=O)n1Cc1ccco1 by removing a benzene_ring.,Cc1cccc(C)c1NC(=O)[C@H](C)Sc1nc2ccccc2c(=O)n1Cc1ccco1,benzene_ring
11816,Modify the molecule Cn1cc(N2CCC[C@H](Nc3nccc(OCc4ccccc4)n3)C2)cn1 by removing a amine.,Cn1cc(N2CCC[C@H](Nc3nccc(OCc4ccccc4)n3)C2)cn1,amine
116650,Remove a amide from the molecule Cc1c(Br)cccc1CSCC(=O)NC1CC1.,Cc1c(Br)cccc1CSCC(=O)NC1CC1,amide
36922,Remove a amide from the molecule Cc1cc(C)c(O)c(C(=O)Nc2cc(C(C)C)nn2-c2ncccn2)c1.,Cc1cc(C)c(O)c(C(=O)Nc2cc(C(C)C)nn2-c2ncccn2)c1,amide
25342,Modify the molecule O=C1[C@H](Nc2ccc3c(c2)OCCCO3)CCCN1Cc1ccccc1 by removing a amide.,O=C1[C@H](Nc2ccc3c(c2)OCCCO3)CCCN1Cc1ccccc1,amide
192154,Remove a benzene_ring from the molecule O=C(c1ccc(OC[C@@H]2CCCO2)cc1)N1CCCSc2ccccc21.,O=C(c1ccc(OC[C@@H]2CCCO2)cc1)N1CCCSc2ccccc21,benzene_ring
69893,Please remove a halo from the molecule CC1=C[C@@H]([C@@H]2NN[C@H](S)N2/N=C/c2ccccc2F)N=N1.,CC1=C[C@@H]([C@@H]2NN[C@H](S)N2/N=C/c2ccccc2F)N=N1,halo
124717,Remove a benzene_ring from the molecule C[C@H]([NH2+][C@@H](C)c1ccc2c(c1)OCCO2)C(=O)Nc1ccc(Cl)cc1.,C[C@H]([NH2+][C@@H](C)c1ccc2c(c1)OCCO2)C(=O)Nc1ccc(Cl)cc1,benzene_ring
80188,Please remove a amide from the molecule Cc1ccc(C(=O)Nc2nnc(SCC(=O)c3ccccc3)s2)cc1.,Cc1ccc(C(=O)Nc2nnc(SCC(=O)c3ccccc3)s2)cc1,amide
225863,Remove a amide from the molecule C[C@@H]1C[C@H]([NH3+])CN(CC(=O)Nc2cc(C(C)(C)C)no2)C1.,C[C@@H]1C[C@H]([NH3+])CN(CC(=O)Nc2cc(C(C)(C)C)no2)C1,amide
78730,Please remove a amide from the molecule CC(=O)NC1(c2noc(CCC(=O)NC(C)(C)C)n2)CCCCCC1.,CC(=O)NC1(c2noc(CCC(=O)NC(C)(C)C)n2)CCCCCC1,amide
80101,Please remove a amide from the molecule CCc1ccc(C(=O)N2CC[C@@H](C)[C@@H](O)C2)cc1.,CCc1ccc(C(=O)N2CC[C@@H](C)[C@@H](O)C2)cc1,amide
106883,Modify the molecule CC[C@@H]([NH3+])c1cccc([C@@H]2CCc3cccnc32)c1 by removing a benzene_ring.,CC[C@@H]([NH3+])c1cccc([C@@H]2CCc3cccnc32)c1,benzene_ring
58569,Remove a benzene_ring from the molecule COc1cc(S(=O)(=O)Oc2cc(C)ccc2C)ccc1Cl.,COc1cc(S(=O)(=O)Oc2cc(C)ccc2C)ccc1Cl,benzene_ring
2551,Please remove a benzene_ring from the molecule C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1.,C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1,benzene_ring
168764,Please remove a halo from the molecule CCCc1cc(NC(=O)C(=O)NC[C@@H](C)c2ccc(F)c(F)c2)n(C)n1.,CCCc1cc(NC(=O)C(=O)NC[C@@H](C)c2ccc(F)c(F)c2)n(C)n1,halo
188237,Please remove a halo from the molecule C[C@@H]([NH2+]Cc1cccc2c1OCO2)c1ccc(Cl)s1.,C[C@@H]([NH2+]Cc1cccc2c1OCO2)c1ccc(Cl)s1,halo
38356,Modify the molecule O=[N+]([O-])/C(=C/c1ccccc1[N+](=O)[O-])c1ccccc1 by removing a nitro.,O=[N+]([O-])/C(=C/c1ccccc1[N+](=O)[O-])c1ccccc1,nitro
10445,Remove a benzene_ring from the molecule Cc1cc(-c2csc(CC(=O)N(C)C)n2)c(C)n1NC(=O)c1ccccc1.,Cc1cc(-c2csc(CC(=O)N(C)C)n2)c(C)n1NC(=O)c1ccccc1,benzene_ring
34835,Remove a amine from the molecule CCC1(CC)CCN(c2[nH+]cc(N)cc2C)C1.,CCC1(CC)CCN(c2[nH+]cc(N)cc2C)C1,amine
219095,Please remove a amide from the molecule C=C(C)C[C@@H]1CCC(=O)N1CCc1ccc(OC)cc1.,C=C(C)C[C@@H]1CCC(=O)N1CCc1ccc(OC)cc1,amide
161901,Remove a benzene_ring from the molecule CSc1cccc(NC(=O)CSc2nc([O-])c3c(n2)CC[NH+](Cc2ccc(F)cc2)C3)c1.,CSc1cccc(NC(=O)CSc2nc([O-])c3c(n2)CC[NH+](Cc2ccc(F)cc2)C3)c1,benzene_ring
241661,Modify the molecule O=[N+]([O-])c1ccc([O-])c(/C=[NH+]/Cc2ccccc2)c1 by removing a nitro.,O=[N+]([O-])c1ccc([O-])c(/C=[NH+]/Cc2ccccc2)c1,nitro
169735,Please remove a amide from the molecule CCOC(=O)[C@H]1CCCN(C(=O)Cn2c(SC(F)F)nc3ccccc32)C1.,CCOC(=O)[C@H]1CCCN(C(=O)Cn2c(SC(F)F)nc3ccccc32)C1,amide
205043,Remove a amide from the molecule CN(CCCNC(=O)CN1CC[S@](=O)C(C)(C)C1)c1ccccc1.,CN(CCCNC(=O)CN1CC[S@](=O)C(C)(C)C1)c1ccccc1,amide
204308,Please remove a halo from the molecule N#C/C(=C/c1ccc(OCc2ccccc2F)cc1)C(=O)NCc1ccccc1.,N#C/C(=C/c1ccc(OCc2ccccc2F)cc1)C(=O)NCc1ccccc1,halo
39316,Remove a halo from the molecule Cc1cc(CN2CC(=O)N[C@@H](C)C2=O)cc(C)c1F.,Cc1cc(CN2CC(=O)N[C@@H](C)C2=O)cc(C)c1F,halo
12975,Please remove a halo from the molecule C[C@H](C(=O)NCCc1ccco1)n1c(=O)c(C(F)(F)F)nc2ccccc21.,C[C@H](C(=O)NCCc1ccco1)n1c(=O)c(C(F)(F)F)nc2ccccc21,halo
67361,Please remove a benzene_ring from the molecule CN(C(=O)c1cc(F)cc(F)c1)C1CCCCCC1.,CN(C(=O)c1cc(F)cc(F)c1)C1CCCCCC1,benzene_ring
222153,Please remove a amine from the molecule COc1ccc(NC(=O)c2cccc(C)c2)cc1N.,COc1ccc(NC(=O)c2cccc(C)c2)cc1N,amine
222221,Please remove a amide from the molecule CN(C(=O)[C@H]1CCCN1C(=O)Cc1cccs1)C1CCS(=O)CC1.,CN(C(=O)[C@H]1CCCN1C(=O)Cc1cccs1)C1CCS(=O)CC1,amide
42876,Modify the molecule COC[C@H](C)[NH+]1CCN(CC(=O)N[C@H]2CCCC[C@H]2C)CC1 by removing a amide.,COC[C@H](C)[NH+]1CCN(CC(=O)N[C@H]2CCCC[C@H]2C)CC1,amide
237791,Modify the molecule Cc1cccc(OC(=O)c2cc(C3CC3)[nH]n2)c1 by removing a benzene_ring.,Cc1cccc(OC(=O)c2cc(C3CC3)[nH]n2)c1,benzene_ring
242972,Modify the molecule CC[C@@H](C)NC(=O)CCNC(=O)N[C@@H](C)c1c(C)noc1C by removing a amide.,CC[C@@H](C)NC(=O)CCNC(=O)N[C@@H](C)c1c(C)noc1C,amide
75382,Modify the molecule COc1ccccc1/C=C/C(=O)[C@@H](C#N)c1nnc2n1CCCCC2 by removing a nitrile.,COc1ccccc1/C=C/C(=O)[C@@H](C#N)c1nnc2n1CCCCC2,nitrile
149371,Remove a benzene_ring from the molecule Cc1ccc(N(Cc2ccon2)Cc2ccco2)cc1.,Cc1ccc(N(Cc2ccon2)Cc2ccco2)cc1,benzene_ring
243519,Modify the molecule C[NH2+][C@H](CCO)CN1CC[NH+]2CCCC[C@@H]2C1 by removing a hydroxyl.,C[NH2+][C@H](CCO)CN1CC[NH+]2CCCC[C@@H]2C1,hydroxyl
229391,Remove a benzene_ring from the molecule CC(C)(C)[NH2+]C[C@H](c1ccccc1Cl)[C@@H]1CCS(=O)(=O)C1.,CC(C)(C)[NH2+]C[C@H](c1ccccc1Cl)[C@@H]1CCS(=O)(=O)C1,benzene_ring
238167,Please remove a amine from the molecule COc1ccccc1NC(=O)[C@@H]1Sc2nnc(C)n2N[C@@H]1c1ccccc1.,COc1ccccc1NC(=O)[C@@H]1Sc2nnc(C)n2N[C@@H]1c1ccccc1,amine
209745,Modify the molecule Cc1ccc(S(=O)(=O)Nc2cccc(C(=O)Nc3nc(-c4ccc5c(c4)OCO5)cs3)c2)cc1 by removing a benzene_ring.,Cc1ccc(S(=O)(=O)Nc2cccc(C(=O)Nc3nc(-c4ccc5c(c4)OCO5)cs3)c2)cc1,benzene_ring
54609,Modify the molecule C[C@@H](Oc1ccc(Cl)cc1)C(=O)Nc1cccc(C(=O)N2CCCC2)c1 by removing a amide.,C[C@@H](Oc1ccc(Cl)cc1)C(=O)Nc1cccc(C(=O)N2CCCC2)c1,amide
12211,Please remove a amide from the molecule CCCCN(CC)C(=O)[C@@H]1CC(=O)N(c2ccc(NC(C)=O)cc2)C1.,CCCCN(CC)C(=O)[C@@H]1CC(=O)N(c2ccc(NC(C)=O)cc2)C1,amide
186778,Please remove a amine from the molecule CCOc1c(C)cc(S(=O)(=O)NC[C@](C)(O)C2CC2)cc1C.,CCOc1c(C)cc(S(=O)(=O)NC[C@](C)(O)C2CC2)cc1C,amine
248523,Please remove a benzene_ring from the molecule CCN(CCO)C(=O)Nc1c(C)cccc1C.,CCN(CCO)C(=O)Nc1c(C)cccc1C,benzene_ring
29165,Modify the molecule CC(C)Oc1ccc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)cc1 by removing a amide.,CC(C)Oc1ccc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)cc1,amide
47558,Modify the molecule CCC(=O)NCc1ccccc1Cl by removing a halo.,CCC(=O)NCc1ccccc1Cl,halo
198391,Remove a benzene_ring from the molecule Cc1ccc([C@H]2CN([C@@H]3CCOC3=O)CCO2)c(C)c1.,Cc1ccc([C@H]2CN([C@@H]3CCOC3=O)CCO2)c(C)c1,benzene_ring
12742,Please remove a benzene_ring from the molecule CC(C)CCNC(=O)c1cccc(S(=O)(=O)N[C@@H]2CCCNC2=O)c1.,CC(C)CCNC(=O)c1cccc(S(=O)(=O)N[C@@H]2CCCNC2=O)c1,benzene_ring
213447,Remove a benzene_ring from the molecule COc1cccc(N/N=C2/C(=N)[N-]N(C(C)=O)C2=N)c1.,COc1cccc(N/N=C2/C(=N)[N-]N(C(C)=O)C2=N)c1,benzene_ring
69656,Modify the molecule CCC[NH2+][C@@]1(CO)CC[C@@H](N2C[C@H](C)OC[C@@H]2CC)C1 by removing a hydroxyl.,CCC[NH2+][C@@]1(CO)CC[C@@H](N2C[C@H](C)OC[C@@H]2CC)C1,hydroxyl
220075,Please remove a amide from the molecule CN(Cc1ccc(Cl)nc1)C(=O)[C@@H]1C[C@H]2CC[C@@H]1O2.,CN(Cc1ccc(Cl)nc1)C(=O)[C@@H]1C[C@H]2CC[C@@H]1O2,amide
144863,Remove a amide from the molecule C#CCN1CCC(C(=O)N2CCC[C@@H]2c2ccc(C(C)C)cc2)CC1.,C#CCN1CCC(C(=O)N2CCC[C@@H]2c2ccc(C(C)C)cc2)CC1,amide
206921,Please remove a amide from the molecule CC[C@H](C)C[C@H](C)NC(=O)N[C@@H]1CCN(c2cnn(C)c2)C1=O.,CC[C@H](C)C[C@H](C)NC(=O)N[C@@H]1CCN(c2cnn(C)c2)C1=O,amide
120091,Please remove a hydroxyl from the molecule C[NH+]1CCC(CCNC(=O)N[C@@H]2CCC[C@@H]2CO)CC1.,C[NH+]1CCC(CCNC(=O)N[C@@H]2CCC[C@@H]2CO)CC1,hydroxyl
220800,Remove a benzene_ring from the molecule Cc1ccn(C/C=C/c2ccccc2)c(=O)c1.,Cc1ccn(C/C=C/c2ccccc2)c(=O)c1,benzene_ring
113902,Remove a benzene_ring from the molecule Cc1ccc([C@@H](NC(=O)C[C@H](NC(N)=O)c2ccccc2)c2ccccc2)cc1C.,Cc1ccc([C@@H](NC(=O)C[C@H](NC(N)=O)c2ccccc2)c2ccccc2)cc1C,benzene_ring
184331,Please remove a amide from the molecule COC(=O)c1ccc(CNC(=O)c2cn(C[C@@H]3CCCO3)nn2)cc1.,COC(=O)c1ccc(CNC(=O)c2cn(C[C@@H]3CCCO3)nn2)cc1,amide
96495,Please remove a amine from the molecule CCOC(=O)C1CCC(Nc2ccc(Cn3cccn3)cc2)CC1.,CCOC(=O)C1CCC(Nc2ccc(Cn3cccn3)cc2)CC1,amine
77395,Remove a benzene_ring from the molecule COc1ccc(OC)c([C@H](C)NC(=O)C2CCOCC2)c1.,COc1ccc(OC)c([C@H](C)NC(=O)C2CCOCC2)c1,benzene_ring
58080,Remove a halo from the molecule CC[NH+](Cc1ccccc1Cl)Cn1nc(-c2ccncc2)n(C2CC2)c1=S.,CC[NH+](Cc1ccccc1Cl)Cn1nc(-c2ccncc2)n(C2CC2)c1=S,halo
53670,Modify the molecule Cc1n[nH]c(C)c1CNC(=O)c1ccnc(OC(C)(C)C)c1 by removing a amide.,Cc1n[nH]c(C)c1CNC(=O)c1ccnc(OC(C)(C)C)c1,amide
118883,Remove a benzene_ring from the molecule CCOC(=O)[C@H]1CC(=O)N(c2ccc(CN3CCOCC3)cc2)C1.,CCOC(=O)[C@H]1CC(=O)N(c2ccc(CN3CCOCC3)cc2)C1,benzene_ring
108219,Remove a benzene_ring from the molecule Cc1ccccc1OCC(=O)N/N=C/c1ccc(N2CCCCCC2)o1.,Cc1ccccc1OCC(=O)N/N=C/c1ccc(N2CCCCCC2)o1,benzene_ring
133024,Please remove a halo from the molecule Cn1cc(I)c(=O)n(CC(=O)NC[C@H]2CCCO2)c1=O.,Cn1cc(I)c(=O)n(CC(=O)NC[C@H]2CCCO2)c1=O,halo
237761,Modify the molecule COc1ccc(C[NH+]2CC[C@]3(CCC[NH+](CC4CCC4)C3)C2)cc1 by removing a benzene_ring.,COc1ccc(C[NH+]2CC[C@]3(CCC[NH+](CC4CCC4)C3)C2)cc1,benzene_ring
213747,Please remove a benzene_ring from the molecule CC(C)Sc1ccc([C@@H](C)NC(=O)[C@@H]2COCCO2)cc1.,CC(C)Sc1ccc([C@@H](C)NC(=O)[C@@H]2COCCO2)cc1,benzene_ring
59060,Remove a hydroxyl from the molecule CC[NH2+][C@]1(CO)CC[C@@H](Sc2ccc(C(C)(C)C)cc2)C1.,CC[NH2+][C@]1(CO)CC[C@@H](Sc2ccc(C(C)(C)C)cc2)C1,hydroxyl
132817,Remove a halo from the molecule O=C1N=C2C=C(c3ccccc3)S[C@H]2C(=O)N1c1ccc(Cl)cc1.,O=C1N=C2C=C(c3ccccc3)S[C@H]2C(=O)N1c1ccc(Cl)cc1,halo
41166,Modify the molecule CS(=O)(=O)N1CCC[C@@H](CN2CCCc3c(F)cccc32)C1 by removing a halo.,CS(=O)(=O)N1CCC[C@@H](CN2CCCc3c(F)cccc32)C1,halo
230244,Remove a benzene_ring from the molecule O=C(Nc1ccc(N2CCCN(c3ccc(Cl)nn3)CC2)c(C(=O)[O-])c1)c1ccc(F)cc1.,O=C(Nc1ccc(N2CCCN(c3ccc(Cl)nn3)CC2)c(C(=O)[O-])c1)c1ccc(F)cc1,benzene_ring
43443,Modify the molecule C[C@H]1CCC[C@@H](CCNC(=O)c2ccccc2Cn2cncn2)C1 by removing a amide.,C[C@H]1CCC[C@@H](CCNC(=O)c2ccccc2Cn2cncn2)C1,amide
13961,Please remove a amide from the molecule Cc1c(C[NH+]2CCn3nc(C(=O)NCCO)cc3C2)[nH]c2ccc(F)cc12.,Cc1c(C[NH+]2CCn3nc(C(=O)NCCO)cc3C2)[nH]c2ccc(F)cc12,amide
51190,Remove a amide from the molecule CS(=O)(=O)N1CCN(C(=O)c2cn(Cc3ccccc3)c3ccccc23)CC1.,CS(=O)(=O)N1CCN(C(=O)c2cn(Cc3ccccc3)c3ccccc23)CC1,amide
162615,Modify the molecule COC(=O)[C@@H]1CCC[C@@H]1NC(=O)c1cccc(Nc2cnn(C)c2)c1 by removing a amide.,COC(=O)[C@@H]1CCC[C@@H]1NC(=O)c1cccc(Nc2cnn(C)c2)c1,amide
162780,Remove a hydroxyl from the molecule C[C@H]1CCN(C(=O)NC[C@@H]2CCC[NH+](C)[C@@H]2c2cccs2)C[C@H]1O.,C[C@H]1CCN(C(=O)NC[C@@H]2CCC[NH+](C)[C@@H]2c2cccs2)C[C@H]1O,hydroxyl
178657,Remove a halo from the molecule O=C([O-])C1CCN(C(=O)COc2ccc(Cl)cc2Cl)CC1.,O=C([O-])C1CCN(C(=O)COc2ccc(Cl)cc2Cl)CC1,halo
248776,Please remove a amide from the molecule CCCN1C(=O)S[C@H](Nc2ccccc2)C1=O.,CCCN1C(=O)S[C@H](Nc2ccccc2)C1=O,amide
69433,Please remove a amide from the molecule CCn1c(SCC(=O)Nc2cccc3cn[nH]c23)nnc1-c1cccc(C)c1.,CCn1c(SCC(=O)Nc2cccc3cn[nH]c23)nnc1-c1cccc(C)c1,amide
18715,Please remove a benzene_ring from the molecule Cc1ccccc1Cc1nnc(NC(=O)C[C@H]2C[NH2+]CCO2)s1.,Cc1ccccc1Cc1nnc(NC(=O)C[C@H]2C[NH2+]CCO2)s1,benzene_ring
147308,Please remove a halo from the molecule CC[NH+](CC)CCn1c([C@H](C)Cl)nc2cnccc21.,CC[NH+](CC)CCn1c([C@H](C)Cl)nc2cnccc21,halo
160990,Remove a benzene_ring from the molecule CCN(Cc1ccccc1)C1(C[NH3+])CCCC1.,CCN(Cc1ccccc1)C1(C[NH3+])CCCC1,benzene_ring
54182,Remove a amide from the molecule CC(C)Cn1c(C[C@H]2CCN(C(=O)C(C)(C)C)C2)nc2cccnc21.,CC(C)Cn1c(C[C@H]2CCN(C(=O)C(C)(C)C)C2)nc2cccnc21,amide
158845,Modify the molecule Cc1cccc2nc(C(=O)O[C@@H](C)C(=O)Nc3cccc(C(F)(F)F)c3)cn12 by removing a amide.,Cc1cccc2nc(C(=O)O[C@@H](C)C(=O)Nc3cccc(C(F)(F)F)c3)cn12,amide
129116,Please remove a amide from the molecule CC(C)N(C[C@H]1C[C@@H]1C)C(=O)Cc1c(F)cccc1F.,CC(C)N(C[C@H]1C[C@@H]1C)C(=O)Cc1c(F)cccc1F,amide
99354,Please remove a benzene_ring from the molecule Cc1cc(NC(=O)CNc2ccc(C(=O)N(C)C)c(C)c2)n(C(C)(C)C)n1.,Cc1cc(NC(=O)CNc2ccc(C(=O)N(C)C)c(C)c2)n(C(C)(C)C)n1,benzene_ring
198542,Modify the molecule CN(CCc1ccccn1)C(=O)c1ccccc1Br by removing a amide.,CN(CCc1ccccn1)C(=O)c1ccccc1Br,amide
176596,Modify the molecule CC1=C(c2ccccc2)C(=O)O[C@@H]2C[C@@H](Cl)CC[C@@H]12 by removing a halo.,CC1=C(c2ccccc2)C(=O)O[C@@H]2C[C@@H](Cl)CC[C@@H]12,halo
9739,Please remove a benzene_ring from the molecule CC(C)CN(C(=O)Cc1ccccc1Cl)c1c(N)n(CC(C)C)c(=O)[nH]c1=O.,CC(C)CN(C(=O)Cc1ccccc1Cl)c1c(N)n(CC(C)C)c(=O)[nH]c1=O,benzene_ring
156694,Please remove a benzene_ring from the molecule Cc1ccsc1[C@H](O)c1ccccc1C1CC1.,Cc1ccsc1[C@H](O)c1ccccc1C1CC1,benzene_ring
19003,Modify the molecule CC[NH+](Cc1cccc(C)n1)Cc1cc(C(=O)NN)no1 by removing a amine.,CC[NH+](Cc1cccc(C)n1)Cc1cc(C(=O)NN)no1,amine
148773,Please remove a amide from the molecule CCN(C(=O)c1ccc(-n2nc(C)nc2C)cc1)C1CCCCC1.,CCN(C(=O)c1ccc(-n2nc(C)nc2C)cc1)C1CCCCC1,amide
234166,Please remove a benzene_ring from the molecule Cc1ccc(N2C[C@@H](C(=O)NCCS(=O)(=O)N3CCN(c4ccccc4)CC3)CC2=O)cc1.,Cc1ccc(N2C[C@@H](C(=O)NCCS(=O)(=O)N3CCN(c4ccccc4)CC3)CC2=O)cc1,benzene_ring
199887,Remove a nitrile from the molecule CCn1ncc([C@H]2C(C#N)=C(N)OC3=C2C(=O)CCC3)c1C.,CCn1ncc([C@H]2C(C#N)=C(N)OC3=C2C(=O)CCC3)c1C,nitrile
224389,Remove a amide from the molecule CC(C)[NH+]1CCC(C(=O)Nc2nnc(C(F)(F)F)s2)CC1.,CC(C)[NH+]1CCC(C(=O)Nc2nnc(C(F)(F)F)s2)CC1,amide
213681,Modify the molecule Cc1cc2c(cc1C)O[C@@H](C(=O)NCc1nnc3ccccn13)C2 by removing a amide.,Cc1cc2c(cc1C)O[C@@H](C(=O)NCc1nnc3ccccn13)C2,amide
37666,Modify the molecule COC(=O)[C@H](C)NC(=O)c1cnn(-c2cccc(Cl)c2)c1 by removing a benzene_ring.,COC(=O)[C@H](C)NC(=O)c1cnn(-c2cccc(Cl)c2)c1,benzene_ring
167226,Modify the molecule N/C(=N\OC(=O)c1ccc2ccccc2c1)c1ccccc1Cl by removing a amine.,N/C(=N\OC(=O)c1ccc2ccccc2c1)c1ccccc1Cl,amine
18723,Remove a benzene_ring from the molecule COc1ccccc1CNC(=O)N(C)Cc1nnc(C2CC2)n1C.,COc1ccccc1CNC(=O)N(C)Cc1nnc(C2CC2)n1C,benzene_ring
235545,Please remove a halo from the molecule CC[C@@](C)([C@@H](N)c1cccc(Cl)c1)[NH+](C)C.,CC[C@@](C)([C@@H](N)c1cccc(Cl)c1)[NH+](C)C,halo
11017,Remove a hydroxyl from the molecule CCOC(=O)c1ccc(C[NH+]2CCCC[C@H]2[C@H](O)CC)o1.,CCOC(=O)c1ccc(C[NH+]2CCCC[C@H]2[C@H](O)CC)o1,hydroxyl
226519,Please remove a halo from the molecule CCC1=NN(C(=O)c2ccc(F)cc2)[C@@](O)(C(F)(F)F)C1.,CCC1=NN(C(=O)c2ccc(F)cc2)[C@@](O)(C(F)(F)F)C1,halo
25694,Modify the molecule O=C([C@@H]1C[C@@H]1[N+](=O)[O-])N1CCS(=O)(=O)C[C@H]1c1ccccc1 by removing a benzene_ring.,O=C([C@@H]1C[C@@H]1[N+](=O)[O-])N1CCS(=O)(=O)C[C@H]1c1ccccc1,benzene_ring
163397,Modify the molecule CC1CCC(N(C)C(=O)CS(=O)(=O)[C@@H](C)C(C)C)CC1 by removing a amide.,CC1CCC(N(C)C(=O)CS(=O)(=O)[C@@H](C)C(C)C)CC1,amide
62192,Please remove a amine from the molecule CNC(=O)c1cccnc1N[C@@H]1C[C@H]2CC[C@@H]1O2.,CNC(=O)c1cccnc1N[C@@H]1C[C@H]2CC[C@@H]1O2,amine
191671,Please remove a benzene_ring from the molecule C(=N/Nc1nn2cnnc2c2ccccc12)\c1ccc(OCc2ccccc2)cc1.,C(=N/Nc1nn2cnnc2c2ccccc12)\c1ccc(OCc2ccccc2)cc1,benzene_ring
105992,Modify the molecule CC(C)(C)[C@H](O)CNC(=O)NC[C@H](c1ccc(Cl)cc1)n1cccn1 by removing a hydroxyl.,CC(C)(C)[C@H](O)CNC(=O)NC[C@H](c1ccc(Cl)cc1)n1cccn1,hydroxyl
162680,Modify the molecule Cc1cc(C)nc(N2CCC(Oc3ccnc(C(N)=O)c3)CC2)n1 by removing a amide.,Cc1cc(C)nc(N2CCC(Oc3ccnc(C(N)=O)c3)CC2)n1,amide
75321,Please remove a hydroxyl from the molecule C/C(=C1\C(=O)NC(=O)N=C1[O-])c1cc(C)ccc1O.,C/C(=C1\C(=O)NC(=O)N=C1[O-])c1cc(C)ccc1O,hydroxyl
31465,Modify the molecule CC(=O)c1cccc(S(=O)(=O)Nc2cc(Cl)ccc2F)c1 by removing a amine.,CC(=O)c1cccc(S(=O)(=O)Nc2cc(Cl)ccc2F)c1,amine
115675,Remove a benzene_ring from the molecule Cc1ccc(NC(=O)c2ccccc2NC(=O)c2cc(C)n(C)n2)c(C(=O)c2ccccc2)c1.,Cc1ccc(NC(=O)c2ccccc2NC(=O)c2cc(C)n(C)n2)c(C(=O)c2ccccc2)c1,benzene_ring
38832,Modify the molecule CCN(Cc1ccccn1)C(=O)[C@H]1C[C@H]1c1ccc(Cl)cc1 by removing a halo.,CCN(Cc1ccccn1)C(=O)[C@H]1C[C@H]1c1ccc(Cl)cc1,halo
161588,Remove a halo from the molecule Cc1ccc([C@H](C)[NH+]2CCCC[C@@H]2[C@@H]2CCCN2)cc1F.,Cc1ccc([C@H](C)[NH+]2CCCC[C@@H]2[C@@H]2CCCN2)cc1F,halo
163986,Modify the molecule Cc1cc([C@H]2C(C#N)=C(N)SC(=N)[C@H]2C#N)c(C)s1 by removing a amine.,Cc1cc([C@H]2C(C#N)=C(N)SC(=N)[C@H]2C#N)c(C)s1,amine
190026,Please remove a benzene_ring from the molecule C[C@@H](c1cccc(C(F)(F)F)c1)[NH+]1CC[C@@H](C(=O)[O-])[C@H]1C.,C[C@@H](c1cccc(C(F)(F)F)c1)[NH+]1CC[C@@H](C(=O)[O-])[C@H]1C,benzene_ring
246940,Please remove a hydroxyl from the molecule CC1CC[NH+]([C@@H](C)CNC(=O)NC[C@@H](C)C[C@@H](C)O)CC1.,CC1CC[NH+]([C@@H](C)CNC(=O)NC[C@@H](C)C[C@@H](C)O)CC1,hydroxyl
157663,Modify the molecule CC[C@@H](NC(=O)[C@@H]1Cc2cc(C)c(C)cc2O1)c1nc2ccccc2[nH]1 by removing a amide.,CC[C@@H](NC(=O)[C@@H]1Cc2cc(C)c(C)cc2O1)c1nc2ccccc2[nH]1,amide
248167,Modify the molecule Cc1cccc(C(C)C)c1NC(=O)c1ccc2c([O-])n(C)c(=S)nc2c1 by removing a amide.,Cc1cccc(C(C)C)c1NC(=O)c1ccc2c([O-])n(C)c(=S)nc2c1,amide
235145,Modify the molecule O=S1(=O)C[C@@H](OS(=O)(=O)[O-])[C@H](c2ccccc2)C1 by removing a benzene_ring.,O=S1(=O)C[C@@H](OS(=O)(=O)[O-])[C@H](c2ccccc2)C1,benzene_ring
127787,Remove a amide from the molecule C[C@H]1CCCCN1C(=O)CNC(=O)CNC(=O)c1ccc(Cl)cc1Cl.,C[C@H]1CCCCN1C(=O)CNC(=O)CNC(=O)c1ccc(Cl)cc1Cl,amide
174180,Modify the molecule CC[C@@H](c1ccccc1)[S@@](=O)Cc1coc(-c2cccs2)n1 by removing a benzene_ring.,CC[C@@H](c1ccccc1)[S@@](=O)Cc1coc(-c2cccs2)n1,benzene_ring
7470,Remove a amide from the molecule CC(=O)N/C(=C/c1ccccc1)C(=O)Nc1cccc(C(C)=O)c1.,CC(=O)N/C(=C/c1ccccc1)C(=O)Nc1cccc(C(C)=O)c1,amide
55190,Modify the molecule Cc1cc(C)cc(C(=O)NCC(=O)NCc2cnn(-c3ccccc3)c2)c1 by removing a benzene_ring.,Cc1cc(C)cc(C(=O)NCC(=O)NCc2cnn(-c3ccccc3)c2)c1,benzene_ring
209595,Please remove a amine from the molecule Cc1c(NC(=O)c2ccccc2)cccc1N[C@H](C)C(=O)Nc1cccc(C#N)c1.,Cc1c(NC(=O)c2ccccc2)cccc1N[C@H](C)C(=O)Nc1cccc(C#N)c1,amine
163836,Modify the molecule Cc1cc(Br)ccc1OCCCN1CC[NH2+]CC1 by removing a halo.,Cc1cc(Br)ccc1OCCCN1CC[NH2+]CC1,halo
158002,Remove a amide from the molecule CC(C)[C@@H](NC(=O)CCl)c1ccccc1.,CC(C)[C@@H](NC(=O)CCl)c1ccccc1,amide
60563,Remove a amide from the molecule C[C@H](c1cccs1)N(C)C(=O)[C@@H]1CC[C@H](C[NH3+])O1.,C[C@H](c1cccs1)N(C)C(=O)[C@@H]1CC[C@H](C[NH3+])O1,amide
232031,Modify the molecule Cc1ccc(-c2ccc(=O)[nH]n2)cc1S(=O)(=O)N(C)c1ccccc1 by removing a benzene_ring.,Cc1ccc(-c2ccc(=O)[nH]n2)cc1S(=O)(=O)N(C)c1ccccc1,benzene_ring
214555,Modify the molecule O=C(OCCN1C(=O)c2ccccc2C1=O)c1ccccc1C(=O)c1ccccc1 by removing a amide.,O=C(OCCN1C(=O)c2ccccc2C1=O)c1ccccc1C(=O)c1ccccc1,amide
169319,Modify the molecule COc1ccc(/C=N/NC(=O)C(C)(C)O)cc1OC(C)C by removing a hydroxyl.,COc1ccc(/C=N/NC(=O)C(C)(C)O)cc1OC(C)C,hydroxyl
184414,Remove a benzene_ring from the molecule CCOc1cc(NC(=O)c2ccc(F)c(COC)c2)ccc1OC.,CCOc1cc(NC(=O)c2ccc(F)c(COC)c2)ccc1OC,benzene_ring
98413,Remove a benzene_ring from the molecule CCc1ccc([C@H](C)CC(=O)N2CCC[C@H](NC(=O)C(C)C)C2)cc1.,CCc1ccc([C@H](C)CC(=O)N2CCC[C@H](NC(=O)C(C)C)C2)cc1,benzene_ring
244557,Please remove a nitrile from the molecule C[C@H](C#N)CNC(=O)c1cccc(SCC#N)c1.,C[C@H](C#N)CNC(=O)c1cccc(SCC#N)c1,nitrile
121984,Remove a benzene_ring from the molecule CC[S@](=O)c1ccccc1C(=O)N[C@@H](c1ccccc1)c1ccc(OC)cc1.,CC[S@](=O)c1ccccc1C(=O)N[C@@H](c1ccccc1)c1ccc(OC)cc1,benzene_ring
27751,Remove a hydroxyl from the molecule COc1cc(Cl)ccc1/N=C/c1cc(Br)ccc1O.,COc1cc(Cl)ccc1/N=C/c1cc(Br)ccc1O,hydroxyl
135894,Modify the molecule CC(=O)NCc1ccc(C(=O)N[C@@H]2C[C@@H]3CCCc4cccc2c43)s1 by removing a amide.,CC(=O)NCc1ccc(C(=O)N[C@@H]2C[C@@H]3CCCc4cccc2c43)s1,amide
68516,Remove a amide from the molecule O=C(Cn1c(CCNC(=O)c2cccc(Br)c2)nc2ccccc21)c1ccccc1.,O=C(Cn1c(CCNC(=O)c2cccc(Br)c2)nc2ccccc21)c1ccccc1,amide
147159,Modify the molecule Cc1ccc(C)c(NC(=O)CN2C(=O)CC3(CCCCC3)C2=O)c1 by removing a benzene_ring.,Cc1ccc(C)c(NC(=O)CN2C(=O)CC3(CCCCC3)C2=O)c1,benzene_ring
57131,Please remove a amide from the molecule Cc1cccn2c(=O)c(C(=O)Nc3ccc4c(c3)CC(=O)N4)cnc12.,Cc1cccn2c(=O)c(C(=O)Nc3ccc4c(c3)CC(=O)N4)cnc12,amide
101873,Modify the molecule CCc1ocnc1C(=O)N[C@H](C)Cc1c(Cl)cccc1Cl by removing a halo.,CCc1ocnc1C(=O)N[C@H](C)Cc1c(Cl)cccc1Cl,halo
211541,Modify the molecule CC[C@H](C)NC(=O)[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 by removing a benzene_ring.,CC[C@H](C)NC(=O)[C@@H]1CCCCN1S(=O)(=O)c1ccccc1,benzene_ring
94853,Remove a amide from the molecule O=C(NC(=S)Nc1ccccc1N1CCCC1)c1ccc(-c2cccc([N+](=O)[O-])c2)o1.,O=C(NC(=S)Nc1ccccc1N1CCCC1)c1ccc(-c2cccc([N+](=O)[O-])c2)o1,amide
90652,Modify the molecule CCNC(=O)N1CC[C@@H](NC(=O)N[C@@H]2CCCc3ccc(F)cc32)C1 by removing a halo.,CCNC(=O)N1CC[C@@H](NC(=O)N[C@@H]2CCCc3ccc(F)cc32)C1,halo
166381,Modify the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)[C@@H](C)N1CCN(C(=O)N(C)C)CC1 by removing a benzene_ring.,Cc1ccc([N+](=O)[O-])cc1NC(=O)[C@@H](C)N1CCN(C(=O)N(C)C)CC1,benzene_ring
100993,Modify the molecule C[C@@H]1CN(C(=O)c2cc(S(C)(=O)=O)c(Cl)cc2Cl)C[C@@H](C)O1 by removing a halo.,C[C@@H]1CN(C(=O)c2cc(S(C)(=O)=O)c(Cl)cc2Cl)C[C@@H](C)O1,halo
1574,Remove a benzene_ring from the molecule CCn1cnnc1SCC(=O)c1ccc(OC)cc1OC.,CCn1cnnc1SCC(=O)c1ccc(OC)cc1OC,benzene_ring
178706,Remove a amide from the molecule CCCc1ncc(C(=O)N(C)[C@@H](C)CSCC)s1.,CCCc1ncc(C(=O)N(C)[C@@H](C)CSCC)s1,amide
43479,Modify the molecule C[C@@H](NC(=O)Nc1ccc(OCCC(N)=O)cc1)c1ccc(Cl)cc1 by removing a benzene_ring.,C[C@@H](NC(=O)Nc1ccc(OCCC(N)=O)cc1)c1ccc(Cl)cc1,benzene_ring
87680,Please remove a amide from the molecule C[C@@H](SCC(=O)N1CCO[C@H]2CCCC[C@@H]21)c1cccs1.,C[C@@H](SCC(=O)N1CCO[C@H]2CCCC[C@@H]21)c1cccs1,amide
218129,Remove a benzene_ring from the molecule COc1ccc([C@H](C(=O)[O-])c2ccc([O-])nn2)cc1.,COc1ccc([C@H](C(=O)[O-])c2ccc([O-])nn2)cc1,benzene_ring
66432,Modify the molecule Cc1n[nH]c(C(c2ccccc2)c2ccccc2)c1C(=O)NN by removing a amine.,Cc1n[nH]c(C(c2ccccc2)c2ccccc2)c1C(=O)NN,amine
88368,Remove a amine from the molecule COC(=O)c1coc(S(=O)(=O)Nc2c(C)n[nH]c2C)c1.,COC(=O)c1coc(S(=O)(=O)Nc2c(C)n[nH]c2C)c1,amine
193335,Remove a benzene_ring from the molecule C[C@H]1C[C@H](C)C[NH+](Cc2ccccc2CNC(=O)c2ccc(Cl)cc2[N+](=O)[O-])C1.,C[C@H]1C[C@H](C)C[NH+](Cc2ccccc2CNC(=O)c2ccc(Cl)cc2[N+](=O)[O-])C1,benzene_ring
110601,Modify the molecule CCOc1ccccc1/C=C/C(=O)N1CCc2sccc2C1 by removing a amide.,CCOc1ccccc1/C=C/C(=O)N1CCc2sccc2C1,amide
22019,Please remove a amide from the molecule CC(=O)c1ccc(N2CCN(C(=O)c3cccs3)CC2)c(F)c1.,CC(=O)c1ccc(N2CCN(C(=O)c3cccs3)CC2)c(F)c1,amide
69119,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)NCC(=O)N2CCC(C(=O)Nc3ccccc3)CC2)cc1C.,Cc1ccc(C(=O)NCC(=O)N2CCC(C(=O)Nc3ccccc3)CC2)cc1C,benzene_ring
117552,Please remove a hydroxyl from the molecule CCN(CC1CC1)c1ccc([C@@H](C)[NH3+])c(O)c1.,CCN(CC1CC1)c1ccc([C@@H](C)[NH3+])c(O)c1,hydroxyl
94550,Modify the molecule Cc1cccnc1C[NH+](C)Cc1ccc(F)cc1Cl by removing a benzene_ring.,Cc1cccnc1C[NH+](C)Cc1ccc(F)cc1Cl,benzene_ring
187211,Modify the molecule CC[C@H]1CCCC[C@]12CC[NH2+]C[C@@H]2c1ccccc1F by removing a halo.,CC[C@H]1CCCC[C@]12CC[NH2+]C[C@@H]2c1ccccc1F,halo
55523,Remove a amide from the molecule CN(C)C(=O)CCNC(=O)C(=O)Nc1ccnn1C1CCCCC1.,CN(C)C(=O)CCNC(=O)C(=O)Nc1ccnn1C1CCCCC1,amide
170399,Remove a halo from the molecule COc1ccc([C@@H]2[C@@H](C(=O)Nc3cc(Cl)ccc3OC)c3ccccc3C(=O)N2C)cc1.,COc1ccc([C@@H]2[C@@H](C(=O)Nc3cc(Cl)ccc3OC)c3ccccc3C(=O)N2C)cc1,halo
208777,Modify the molecule COc1ccc(OC)c(-c2ccc(SCC(=O)NC(C)C)nn2)c1 by removing a benzene_ring.,COc1ccc(OC)c(-c2ccc(SCC(=O)NC(C)C)nn2)c1,benzene_ring
104192,Modify the molecule [NH3+][C@H]1CCC[C@H](Nc2cccc(-c3cnco3)c2)C1 by removing a benzene_ring.,[NH3+][C@H]1CCC[C@H](Nc2cccc(-c3cnco3)c2)C1,benzene_ring
247037,Modify the molecule CCOc1cc(NC2C[C@H](C)O[C@@H](C)C2)ccc1C by removing a benzene_ring.,CCOc1cc(NC2C[C@H](C)O[C@@H](C)C2)ccc1C,benzene_ring
73247,Please remove a hydroxyl from the molecule C[C@H](CCNC(=O)OCCO)c1ccccc1.,C[C@H](CCNC(=O)OCCO)c1ccccc1,hydroxyl
125238,Remove a benzene_ring from the molecule COc1ccc(Cn2c(CNC(=O)c3ccc(OC)cc3)nc3cccnc32)cc1.,COc1ccc(Cn2c(CNC(=O)c3ccc(OC)cc3)nc3cccnc32)cc1,benzene_ring
232573,Modify the molecule COc1ccc(S(=O)(=O)NCc2nc3nc(C)cc(C)n3n2)cc1 by removing a benzene_ring.,COc1ccc(S(=O)(=O)NCc2nc3nc(C)cc(C)n3n2)cc1,benzene_ring
244818,Modify the molecule CC(C)C[C@H]([NH2+][C@@H]1CSCC(C)(C)C1)c1ccccc1 by removing a benzene_ring.,CC(C)C[C@H]([NH2+][C@@H]1CSCC(C)(C)C1)c1ccccc1,benzene_ring
140231,Please remove a halo from the molecule Cc1cc(N2CCN(C(=O)c3ccc(Cl)s3)CC2)cc(C)[nH+]1.,Cc1cc(N2CCN(C(=O)c3ccc(Cl)s3)CC2)cc(C)[nH+]1,halo
180666,Modify the molecule CC[C@H]([NH3+])[C@@H](c1ccccc1C)N1CCO[C@H](C#N)C1 by removing a nitrile.,CC[C@H]([NH3+])[C@@H](c1ccccc1C)N1CCO[C@H](C#N)C1,nitrile
128367,Please remove a hydroxyl from the molecule Cc1cc(F)ccc1CCNC(=O)NC[C@@](C)(O)C(=O)[O-].,Cc1cc(F)ccc1CCNC(=O)NC[C@@](C)(O)C(=O)[O-],hydroxyl
165071,Remove a nitro from the molecule O=[N+]([O-])c1cccc(-c2csc(N/N=C\c3ccccc3O)n2)c1.,O=[N+]([O-])c1cccc(-c2csc(N/N=C\c3ccccc3O)n2)c1,nitro
72252,Modify the molecule C[C@H]1OCC[C@H]1C(=O)N1CCN(C(=O)c2ccccc2OC(F)F)CC1 by removing a halo.,C[C@H]1OCC[C@H]1C(=O)N1CCN(C(=O)c2ccccc2OC(F)F)CC1,halo
21940,Please remove a halo from the molecule CS(=O)(=O)c1ccc(-n2nnnc2COc2cccc(I)c2)cc1.,CS(=O)(=O)c1ccc(-n2nnnc2COc2cccc(I)c2)cc1,halo
85880,Please remove a amide from the molecule Cc1cccc(NC(=O)[C@H]2CCCN(c3ccnc(-c4ccc(F)cc4)n3)C2)c1.,Cc1cccc(NC(=O)[C@H]2CCCN(c3ccnc(-c4ccc(F)cc4)n3)C2)c1,amide
219869,Please remove a benzene_ring from the molecule Cc1ccc(C)c(-n2ccnc2SCC(=O)NCC(=O)NC2CC2)c1.,Cc1ccc(C)c(-n2ccnc2SCC(=O)NCC(=O)NC2CC2)c1,benzene_ring
226784,Remove a amine from the molecule COC(=O)Nc1cc(NCCOc2ccc(F)cc2Cl)ccc1F.,COC(=O)Nc1cc(NCCOc2ccc(F)cc2Cl)ccc1F,amine
166902,Remove a benzene_ring from the molecule CC[C@H]1CN(C(=O)Nc2ccccc2S(=O)(=O)C(C)C)C[C@H](C)O1.,CC[C@H]1CN(C(=O)Nc2ccccc2S(=O)(=O)C(C)C)C[C@H](C)O1,benzene_ring
179262,Remove a hydroxyl from the molecule COc1ccc2occ(/C(C)=N/O)c2c1.,COc1ccc2occ(/C(C)=N/O)c2c1,hydroxyl
186649,Remove a hydroxyl from the molecule C[C@H]1C[NH+]2CCC[C@@H]2CN1c1ccc(/C(N)=N/O)c(Cl)c1.,C[C@H]1C[NH+]2CCC[C@@H]2CN1c1ccc(/C(N)=N/O)c(Cl)c1,hydroxyl
85716,Remove a amide from the molecule C#Cc1cccc(NC(=S)NNC(=O)CNC(=O)c2ccc(F)cc2F)c1.,C#Cc1cccc(NC(=S)NNC(=O)CNC(=O)c2ccc(F)cc2F)c1,amide
71925,Modify the molecule Cc1cc(C)cc(NC(=O)N2CCSC(C)(C)C2)c1 by removing a benzene_ring.,Cc1cc(C)cc(NC(=O)N2CCSC(C)(C)C2)c1,benzene_ring
167582,Modify the molecule COc1cc(F)c([C@@H](C)NC(=O)COC2CCCCC2)cc1OC by removing a halo.,COc1cc(F)c([C@@H](C)NC(=O)COC2CCCCC2)cc1OC,halo
177720,Please remove a halo from the molecule CN(C(=O)Cn1cccc(C(F)(F)F)c1=O)C1CCOCC1.,CN(C(=O)Cn1cccc(C(F)(F)F)c1=O)C1CCOCC1,halo
64273,Remove a amide from the molecule Cc1n[nH]c(SCCC(=O)N(C)[C@H](C)Cc2ccsc2)n1.,Cc1n[nH]c(SCCC(=O)N(C)[C@H](C)Cc2ccsc2)n1,amide
156967,Please remove a amide from the molecule COc1ccccc1[C@H](C#N)NC(=O)c1c(C)cc(C)c([N+](=O)[O-])c1C.,COc1ccccc1[C@H](C#N)NC(=O)c1c(C)cc(C)c([N+](=O)[O-])c1C,amide
65430,Modify the molecule CCOC(=O)[C@@H](CC)c1nc(CC(F)(F)F)no1 by removing a halo.,CCOC(=O)[C@@H](CC)c1nc(CC(F)(F)F)no1,halo
245544,Remove a amide from the molecule CCc1cccc2c(CC(=O)N3CC[C@@H]4CC[C@H](C3)[NH+]4C)c[nH]c12.,CCc1cccc2c(CC(=O)N3CC[C@@H]4CC[C@H](C3)[NH+]4C)c[nH]c12,amide
191386,Modify the molecule C[C@H]1CN(C(=O)Nc2cccc(F)c2)CC[C@@H]1[NH3+] by removing a benzene_ring.,C[C@H]1CN(C(=O)Nc2cccc(F)c2)CC[C@@H]1[NH3+],benzene_ring
208440,Modify the molecule O=C([C@H]1Cc2ccccc2O1)N1CCN([C@@H]2CCS(=O)(=O)C2)CC1 by removing a amide.,O=C([C@H]1Cc2ccccc2O1)N1CCN([C@@H]2CCS(=O)(=O)C2)CC1,amide
56969,Remove a benzene_ring from the molecule COC(=O)c1c(NC(=O)C(C)C)sc(C(=O)Nc2cccc(C)c2C)c1C.,COC(=O)c1c(NC(=O)C(C)C)sc(C(=O)Nc2cccc(C)c2C)c1C,benzene_ring
10423,Please remove a halo from the molecule Cc1c(C[NH2+][C@@H](C)c2ccc(Cl)s2)cnn1C.,Cc1c(C[NH2+][C@@H](C)c2ccc(Cl)s2)cnn1C,halo
100891,Remove a amide from the molecule CCc1cc([C@H]2CCCN2C(=O)c2ccc(F)cc2)on1.,CCc1cc([C@H]2CCCN2C(=O)c2ccc(F)cc2)on1,amide
5312,Remove a halo from the molecule COC(=O)c1sc2cccc(F)c2c1CSc1nnnn1C.,COC(=O)c1sc2cccc(F)c2c1CSc1nnnn1C,halo
161052,Remove a benzene_ring from the molecule CC[C@H](C(=O)OC)N(C(=O)c1ccnc(Cl)c1)c1ccccc1.,CC[C@H](C(=O)OC)N(C(=O)c1ccnc(Cl)c1)c1ccccc1,benzene_ring
57193,Modify the molecule O=C1CN(S(=O)(=O)c2ccc(-c3ccc(=O)[nH]n3)s2)c2ccccc2N1 by removing a amide.,O=C1CN(S(=O)(=O)c2ccc(-c3ccc(=O)[nH]n3)s2)c2ccccc2N1,amide
191314,Please remove a amine from the molecule N/C(CSc1ccccc1[N+](=O)[O-])=N\O.,N/C(CSc1ccccc1[N+](=O)[O-])=N\O,amine
239155,Please remove a amide from the molecule CC(C)(C)C(=O)NNC(=O)NCc1cccc([N+]2=CCCC2)c1.,CC(C)(C)C(=O)NNC(=O)NCc1cccc([N+]2=CCCC2)c1,amide
59316,Remove a amide from the molecule CCc1cc(=O)[nH]c(-c2cccc(NC(=O)c3ccc4cc[nH]c4c3)c2)n1.,CCc1cc(=O)[nH]c(-c2cccc(NC(=O)c3ccc4cc[nH]c4c3)c2)n1,amide
93139,Remove a halo from the molecule C#CCOc1ccc(F)cc1NC(=O)N[C@H]1CCCC[C@H]1[S@](=O)CC.,C#CCOc1ccc(F)cc1NC(=O)N[C@H]1CCCC[C@H]1[S@](=O)CC,halo
241577,Remove a hydroxyl from the molecule Cc1cccc(COc2cccc3c2CC[C@H]3O)n1.,Cc1cccc(COc2cccc3c2CC[C@H]3O)n1,hydroxyl
212145,Remove a amide from the molecule COC(=O)[C@@H]1CC(=O)N(Cc2ccc3ccccc3c2)C12CC[NH+](Cc1ccco1)CC2.,COC(=O)[C@@H]1CC(=O)N(Cc2ccc3ccccc3c2)C12CC[NH+](Cc1ccco1)CC2,amide
12418,Remove a amide from the molecule C[C@H](Cc1ccccn1)NC(=O)CN1C(=O)[C@H]2CC[C@@](C)(C1=O)C2(C)C.,C[C@H](Cc1ccccn1)NC(=O)CN1C(=O)[C@H]2CC[C@@](C)(C1=O)C2(C)C,amide
57272,Modify the molecule COc1cccc(CNC(=O)c2cnc([C@H]3CCCO3)s2)c1O by removing a benzene_ring.,COc1cccc(CNC(=O)c2cnc([C@H]3CCCO3)s2)c1O,benzene_ring
65014,Modify the molecule Cc1ccc(OC(=O)C=C2CCSCC2)cc1 by removing a benzene_ring.,Cc1ccc(OC(=O)C=C2CCSCC2)cc1,benzene_ring
19949,Remove a benzene_ring from the molecule CC(=O)Nc1ccc(NC(=O)CN2C(=O)c3cccc4cccc2c34)cc1.,CC(=O)Nc1ccc(NC(=O)CN2C(=O)c3cccc4cccc2c34)cc1,benzene_ring
198989,Modify the molecule CCOc1ccc(N2C(=O)S/C(=C/c3ccc(-c4ccccc4[N+](=O)[O-])o3)C2=O)cc1 by removing a nitro.,CCOc1ccc(N2C(=O)S/C(=C/c3ccc(-c4ccccc4[N+](=O)[O-])o3)C2=O)cc1,nitro
7928,Remove a benzene_ring from the molecule [NH3+][C@H]1C[C@H](n2ccc(=O)[nH]c2=O)O[C@@H]1COCc1ccccc1.,[NH3+][C@H]1C[C@H](n2ccc(=O)[nH]c2=O)O[C@@H]1COCc1ccccc1,benzene_ring
123383,Modify the molecule Cc1nn(C(C)C)c(C)c1CN(C)C(=O)C[C@@H]1C(=O)NCC[NH+]1CC(C)C by removing a amide.,Cc1nn(C(C)C)c(C)c1CN(C)C(=O)C[C@@H]1C(=O)NCC[NH+]1CC(C)C,amide
133756,Please remove a hydroxyl from the molecule CC[C@](C)([C@@H](O)c1cnccn1)[NH+]1CCCCC1.,CC[C@](C)([C@@H](O)c1cnccn1)[NH+]1CCCCC1,hydroxyl
100643,Please remove a amide from the molecule CC[C@@H](C)C(=O)NC[C@@H](C)Oc1ccc(Cl)cc1.,CC[C@@H](C)C(=O)NC[C@@H](C)Oc1ccc(Cl)cc1,amide
66696,Modify the molecule C[C@H](Nc1nccc(Oc2ccc(F)cc2)n1)c1cccc(S(N)(=O)=O)c1 by removing a benzene_ring.,C[C@H](Nc1nccc(Oc2ccc(F)cc2)n1)c1cccc(S(N)(=O)=O)c1,benzene_ring
184231,Remove a benzene_ring from the molecule COc1cccc(CNc2ncnc3sccc23)c1.,COc1cccc(CNc2ncnc3sccc23)c1,benzene_ring
161712,Modify the molecule CC(C)(C)C1CCC(=CC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)CC1 by removing a amide.,CC(C)(C)C1CCC(=CC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)CC1,amide
145214,Remove a amide from the molecule Cn1cccc(NC(=O)c2[nH]c3ccc(Cl)cc3c2Cl)c1=O.,Cn1cccc(NC(=O)c2[nH]c3ccc(Cl)cc3c2Cl)c1=O,amide
180853,Modify the molecule C[C@@H]1CCCN1C(=O)c1cc(C(F)(F)F)ccc1NN by removing a halo.,C[C@@H]1CCCN1C(=O)c1cc(C(F)(F)F)ccc1NN,halo
212008,Modify the molecule COc1ccc(CN2CCO[C@@H](CO)C2)cc1[N+](=O)[O-] by removing a benzene_ring.,COc1ccc(CN2CCO[C@@H](CO)C2)cc1[N+](=O)[O-],benzene_ring
98857,Remove a halo from the molecule O=C(c1cccc(Br)c1)N1CCN(C(=O)N2CCCCC2)CC1.,O=C(c1cccc(Br)c1)N1CCN(C(=O)N2CCCCC2)CC1,halo
39204,Remove a hydroxyl from the molecule Oc1ccccc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccc(Cl)cc1Cl.,Oc1ccccc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccc(Cl)cc1Cl,hydroxyl
183977,Modify the molecule Cc1cc([N+](=O)[O-])ccc1NC(=O)C(=O)NCC(C)(C)[C@H](O)c1ccccc1 by removing a hydroxyl.,Cc1cc([N+](=O)[O-])ccc1NC(=O)C(=O)NCC(C)(C)[C@H](O)c1ccccc1,hydroxyl
220644,Please remove a amide from the molecule COCCn1nnnc1C[NH+]1[C@H]2CCC[C@@H]1CC(NC(C)=O)C2.,COCCn1nnnc1C[NH+]1[C@H]2CCC[C@@H]1CC(NC(C)=O)C2,amide
191843,Modify the molecule COc1ccc([C@@H]2NC(=O)C3=NN=C(c4ccc(C)cc4)[C@H]32)cc1 by removing a benzene_ring.,COc1ccc([C@@H]2NC(=O)C3=NN=C(c4ccc(C)cc4)[C@H]32)cc1,benzene_ring
77709,Remove a hydroxyl from the molecule CCC1CCC(C[NH3+])([C@@H](O)c2ccccc2F)CC1.,CCC1CCC(C[NH3+])([C@@H](O)c2ccccc2F)CC1,hydroxyl
181903,Modify the molecule Cc1nc2sc([C@@H](c3ccccc3Cl)N(C)Cc3ccccc3)c([O-])n2n1 by removing a benzene_ring.,Cc1nc2sc([C@@H](c3ccccc3Cl)N(C)Cc3ccccc3)c([O-])n2n1,benzene_ring
69428,Modify the molecule COc1ccc(N2C(=O)C[C@H]([C@@H]3C(=O)N(c4ccccc4)N=C3C)C2=O)cc1 by removing a benzene_ring.,COc1ccc(N2C(=O)C[C@H]([C@@H]3C(=O)N(c4ccccc4)N=C3C)C2=O)cc1,benzene_ring
187779,Please remove a halo from the molecule FC(F)Oc1ccc(N2CCCC3(C2)OCCO3)nc1.,FC(F)Oc1ccc(N2CCCC3(C2)OCCO3)nc1,halo
203945,Remove a amide from the molecule CCCC(=O)N1CCC[C@@H](C(=O)NC(C)(C)c2nc(C)c(C)s2)C1.,CCCC(=O)N1CCC[C@@H](C(=O)NC(C)(C)c2nc(C)c(C)s2)C1,amide
8456,Modify the molecule O=C(N[C@H]1CC=CCC1)N[C@@H]1CCCN(c2ccccc2)C1=O by removing a amide.,O=C(N[C@H]1CC=CCC1)N[C@@H]1CCCN(c2ccccc2)C1=O,amide
8853,Modify the molecule COc1ccccc1-c1nnc(S[C@@H](C)C(=O)Nc2ccccc2C)n1C by removing a amide.,COc1ccccc1-c1nnc(S[C@@H](C)C(=O)Nc2ccccc2C)n1C,amide
164056,Modify the molecule Cc1[nH]c(SCC(=O)NCC(=O)N(C)C)nc1Cc1ccccc1 by removing a amide.,Cc1[nH]c(SCC(=O)NCC(=O)N(C)C)nc1Cc1ccccc1,amide
136596,Please remove a amine from the molecule Cc1cc(Cl)ccc1Nc1ncnc(NCc2cccnc2)c1[N+](=O)[O-].,Cc1cc(Cl)ccc1Nc1ncnc(NCc2cccnc2)c1[N+](=O)[O-],amine
88420,Please remove a halo from the molecule COc1ccc(-c2noc(CCC(=O)N(C)Cc3ccccc3F)n2)cc1.,COc1ccc(-c2noc(CCC(=O)N(C)Cc3ccccc3F)n2)cc1,halo
110252,Modify the molecule CN(C)c1ccccc1NC(=O)NCCCc1nnc2n1CCCCC2 by removing a benzene_ring.,CN(C)c1ccccc1NC(=O)NCCCc1nnc2n1CCCCC2,benzene_ring
129658,Modify the molecule COC(=O)[C@@]1(F)CCN(S(=O)(=O)c2c(F)cccc2F)C1 by removing a benzene_ring.,COC(=O)[C@@]1(F)CCN(S(=O)(=O)c2c(F)cccc2F)C1,benzene_ring
111997,Remove a benzene_ring from the molecule O=C([O-])CCC[NH+]1CCC[C@]2(CCC(=O)N(CCc3ccccc3)C2)C1.,O=C([O-])CCC[NH+]1CCC[C@]2(CCC(=O)N(CCc3ccccc3)C2)C1,benzene_ring
10366,Please remove a benzene_ring from the molecule Cc1cncc(C(=O)O[C@H](Cn2cncn2)c2ccccc2)c1.,Cc1cncc(C(=O)O[C@H](Cn2cncn2)c2ccccc2)c1,benzene_ring
158272,Remove a amide from the molecule Cc1nc(N2C(=O)C([O-])=C(C(=O)c3ccccc3)[C@@H]2c2cccc(Cl)c2)sc1C.,Cc1nc(N2C(=O)C([O-])=C(C(=O)c3ccccc3)[C@@H]2c2cccc(Cl)c2)sc1C,amide
6777,Modify the molecule C[C@@H](C(=O)N1CCCCCC1)S(=O)(=O)c1ccccc1F by removing a halo.,C[C@@H](C(=O)N1CCCCCC1)S(=O)(=O)c1ccccc1F,halo
202563,Remove a benzene_ring from the molecule COc1ccccc1[C@@H]1C[C@H](c2ccccc2)Nc2ncnn21.,COc1ccccc1[C@@H]1C[C@H](c2ccccc2)Nc2ncnn21,benzene_ring
140963,Modify the molecule C[C@@H](OC(=O)c1cc(-c2ccc(Br)cc2)n[nH]1)c1nnc(-c2ccc([N+](=O)[O-])cc2)o1 by removing a benzene_ring.,C[C@@H](OC(=O)c1cc(-c2ccc(Br)cc2)n[nH]1)c1nnc(-c2ccc([N+](=O)[O-])cc2)o1,benzene_ring
40106,Remove a benzene_ring from the molecule COc1ccccc1[C@H](CNC(=O)N(C)Cc1ncnn1C)[NH+]1CCCC1.,COc1ccccc1[C@H](CNC(=O)N(C)Cc1ncnn1C)[NH+]1CCCC1,benzene_ring
100632,Remove a benzene_ring from the molecule Cc1cc(C)n(-c2ccc(C(=O)NCc3cscn3)cc2)n1.,Cc1cc(C)n(-c2ccc(C(=O)NCc3cscn3)cc2)n1,benzene_ring
159225,Remove a amide from the molecule CCC(=O)N[C@H](C)c1nc2ccccc2n1Cc1c(C)cc(C)cc1C.,CCC(=O)N[C@H](C)c1nc2ccccc2n1Cc1c(C)cc(C)cc1C,amide
140807,Modify the molecule CC[C@H]([NH2+][C@H](C)CC1CCOCC1)c1cc(F)ccc1F by removing a benzene_ring.,CC[C@H]([NH2+][C@H](C)CC1CCOCC1)c1cc(F)ccc1F,benzene_ring
115232,Remove a benzene_ring from the molecule O=C(Nc1ccccc1F)[C@@H]1CSCN1C(=O)C=C1CCSCC1.,O=C(Nc1ccccc1F)[C@@H]1CSCN1C(=O)C=C1CCSCC1,benzene_ring
211028,Please remove a amide from the molecule Cc1ccc(C(O)(C(=O)Nc2ccccn2)c2ccc(C)cc2)cc1.,Cc1ccc(C(O)(C(=O)Nc2ccccn2)c2ccc(C)cc2)cc1,amide
15127,Please remove a amide from the molecule C[C@H]1CC(C(=O)N[C@@H]2CC(=O)N(C)[C@@H]2c2ccc(Cl)cc2)C[C@@H](C)O1.,C[C@H]1CC(C(=O)N[C@@H]2CC(=O)N(C)[C@@H]2c2ccc(Cl)cc2)C[C@@H](C)O1,amide
41658,Modify the molecule CC(C)(C)C(=O)N1CCN(C(=O)Nc2cccc(OC3CCCC3)c2)CC1 by removing a amide.,CC(C)(C)C(=O)N1CCN(C(=O)Nc2cccc(OC3CCCC3)c2)CC1,amide
103871,Please remove a amide from the molecule CC(C)COC(=O)c1ccccc1SCC(=O)N1CCCC1.,CC(C)COC(=O)c1ccccc1SCC(=O)N1CCCC1,amide
119586,Please remove a halo from the molecule CCN(Cc1ccc(Cl)s1)C(=O)NC[C@H]1CCOC1.,CCN(Cc1ccc(Cl)s1)C(=O)NC[C@H]1CCOC1,halo
57860,Please remove a benzene_ring from the molecule COc1ccccc1NC1CCN(C(=O)C(=O)Nc2ccc(C)cc2)CC1.,COc1ccccc1NC1CCN(C(=O)C(=O)Nc2ccc(C)cc2)CC1,benzene_ring
67539,Remove a amine from the molecule C[C@@H]1Cc2ccccc2N1CCNC(=O)c1ccc(NS(=O)(=O)c2ccccc2)cc1.,C[C@@H]1Cc2ccccc2N1CCNC(=O)c1ccc(NS(=O)(=O)c2ccccc2)cc1,amine
226294,Remove a amine from the molecule c1ccc2c3c([nH]c2c1)CC[C@H](N[C@@H]1CC[NH+](C2CCCC2)C1)C3.,c1ccc2c3c([nH]c2c1)CC[C@H](N[C@@H]1CC[NH+](C2CCCC2)C1)C3,amine
9779,Please remove a amide from the molecule CO[C@H](C)C(=O)N1CCN(C(=O)Cc2c[nH]c3ccccc23)CC1.,CO[C@H](C)C(=O)N1CCN(C(=O)Cc2c[nH]c3ccccc23)CC1,amide
121657,Please remove a amide from the molecule O=C(CCCn1ccnn1)N1CCN(Cc2noc(-c3cccs3)n2)CC1.,O=C(CCCn1ccnn1)N1CCN(Cc2noc(-c3cccs3)n2)CC1,amide
13636,Please remove a benzene_ring from the molecule CNC(=O)c1cccc(NCc2cn(-c3ccccc3)nc2C(C)C)c1C.,CNC(=O)c1cccc(NCc2cn(-c3ccccc3)nc2C(C)C)c1C,benzene_ring
146459,Remove a amide from the molecule CN1CCC/C1=N\S(=O)(=O)c1cccc(NC(=O)CCn2cnc3ccccc32)c1.,CN1CCC/C1=N\S(=O)(=O)c1cccc(NC(=O)CCn2cnc3ccccc32)c1,amide
93382,Remove a amide from the molecule O=C(Nc1cc(-c2ccco2)ccc1F)c1cn2cccnc2n1.,O=C(Nc1cc(-c2ccco2)ccc1F)c1cn2cccnc2n1,amide
213076,Modify the molecule CN(Cc1cc2ccccc2o1)C(=O)c1ccc(-c2cscn2)cc1 by removing a benzene_ring.,CN(Cc1cc2ccccc2o1)C(=O)c1ccc(-c2cscn2)cc1,benzene_ring
38249,Modify the molecule Cc1nnsc1C(=O)N/N=C/c1ccc([N+](=O)[O-])s1 by removing a nitro.,Cc1nnsc1C(=O)N/N=C/c1ccc([N+](=O)[O-])s1,nitro
194287,Remove a amide from the molecule Cc1cc(C)cc(N2CCN(C(=O)[C@@H]3CN(C)C(=O)N3)CC2=O)c1.,Cc1cc(C)cc(N2CCN(C(=O)[C@@H]3CN(C)C(=O)N3)CC2=O)c1,amide
101774,Please remove a benzene_ring from the molecule O=C(Oc1ccc(-n2cnnn2)cc1)c1ccc(F)cc1.,O=C(Oc1ccc(-n2cnnn2)cc1)c1ccc(F)cc1,benzene_ring
200299,Please remove a amide from the molecule CN(C)c1cccc(C(=O)Nn2cnc3ccccc3c2=O)c1.,CN(C)c1cccc(C(=O)Nn2cnc3ccccc3c2=O)c1,amide
23258,Remove a hydroxyl from the molecule COc1cccc(OC[C@@H](O)CN2CCN(c3cc(Cl)ccc3C)CC2)c1.,COc1cccc(OC[C@@H](O)CN2CCN(c3cc(Cl)ccc3C)CC2)c1,hydroxyl
11793,Remove a benzene_ring from the molecule CN(C)c1ccc(-c2nnn(CC(=O)N3CCCCCC3)n2)cc1.,CN(C)c1ccc(-c2nnn(CC(=O)N3CCCCCC3)n2)cc1,benzene_ring
108754,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)CCC(=O)NCc2ccc(N3CCOCC3)[nH+]c2)cc1.,Cc1ccc(C(=O)CCC(=O)NCc2ccc(N3CCOCC3)[nH+]c2)cc1,benzene_ring
241223,Remove a benzene_ring from the molecule C[C@H](CN(C)C(=O)N[C@@H]1CC[NH+](C2CCCC2)C1)c1ccccc1.,C[C@H](CN(C)C(=O)N[C@@H]1CC[NH+](C2CCCC2)C1)c1ccccc1,benzene_ring
242029,Please remove a amide from the molecule Cc1ccc(Cc2nnc(NC(=O)[C@H]3CCCCN3S(=O)(=O)c3cccs3)o2)cc1C.,Cc1ccc(Cc2nnc(NC(=O)[C@H]3CCCCN3S(=O)(=O)c3cccs3)o2)cc1C,amide
211619,Modify the molecule C[C@H]1CCCC[C@H]1N1C(=O)C(=O)N(Cc2cccc(S(=O)(=O)N3CCOCC3)c2)C1=O by removing a amide.,C[C@H]1CCCC[C@H]1N1C(=O)C(=O)N(Cc2cccc(S(=O)(=O)N3CCOCC3)c2)C1=O,amide
93549,Remove a benzene_ring from the molecule COc1ccc(/C=C/C(=O)N[C@H](C)C(=O)N[C@H]2[C@@H]3CCO[C@@H]3C2(C)C)cc1.,COc1ccc(/C=C/C(=O)N[C@H](C)C(=O)N[C@H]2[C@@H]3CCO[C@@H]3C2(C)C)cc1,benzene_ring
108561,Remove a amine from the molecule COc1ccccc1[C@@H](NS(=O)(=O)C[C@@H]1CCOC1)c1ccccn1.,COc1ccccc1[C@@H](NS(=O)(=O)C[C@@H]1CCOC1)c1ccccn1,amine
107710,Modify the molecule CNC(=O)c1ccccc1NC(=O)[C@@H]1C[C@@H]2C=C[C@H]1C2 by removing a amide.,CNC(=O)c1ccccc1NC(=O)[C@@H]1C[C@@H]2C=C[C@H]1C2,amide
29615,Please remove a amide from the molecule C/C=C/C=C/C(=O)Nc1ccnn1Cc1ccc(Br)cc1.,C/C=C/C=C/C(=O)Nc1ccnn1Cc1ccc(Br)cc1,amide
65808,Please remove a amine from the molecule Cc1ccc(OCC(=O)NC(=S)Nc2cccc(C(=O)[O-])c2C)cc1.,Cc1ccc(OCC(=O)NC(=S)Nc2cccc(C(=O)[O-])c2C)cc1,amine
217862,Remove a benzene_ring from the molecule C[NH2+]CCSCc1ccccc1.,C[NH2+]CCSCc1ccccc1,benzene_ring
184235,Remove a halo from the molecule CC(C)N(C)C(=O)N[C@@H](C)c1c(Cl)ccc(F)c1Cl.,CC(C)N(C)C(=O)N[C@@H](C)c1c(Cl)ccc(F)c1Cl,halo
132484,Modify the molecule O=C(c1ccc2c(c1)COCO2)N1CCCC[C@H]1CCO by removing a amide.,O=C(c1ccc2c(c1)COCO2)N1CCCC[C@H]1CCO,amide
113473,Modify the molecule CC(C)c1nc(-c2ccc(N3CCN(C(=O)Cc4noc5ccccc45)CC3)[nH+]c2)no1 by removing a amide.,CC(C)c1nc(-c2ccc(N3CCN(C(=O)Cc4noc5ccccc45)CC3)[nH+]c2)no1,amide
189828,Remove a benzene_ring from the molecule C[C@@H](Cc1cccs1)N(C)S(=O)(=O)c1ccc(O)cc1.,C[C@@H](Cc1cccs1)N(C)S(=O)(=O)c1ccc(O)cc1,benzene_ring
229882,Remove a benzene_ring from the molecule CCOc1ccc([C@@H]2SCC(=O)Nc3c2c(C)nn3-c2nc3ccccc3s2)cc1.,CCOc1ccc([C@@H]2SCC(=O)Nc3c2c(C)nn3-c2nc3ccccc3s2)cc1,benzene_ring
224675,Remove a halo from the molecule O=C(Cc1ccccc1C(F)(F)F)N[C@@H](CO)c1ccco1.,O=C(Cc1ccccc1C(F)(F)F)N[C@@H](CO)c1ccco1,halo
195066,Please remove a amide from the molecule Cc1cccc(-n2ncc3c(=O)n4c(nc32)SC[C@@H]4CC(=O)NCCCn2ccnc2)c1.,Cc1cccc(-n2ncc3c(=O)n4c(nc32)SC[C@@H]4CC(=O)NCCCn2ccnc2)c1,amide
64114,Modify the molecule C[C@H](O)[C@H]1CCC[NH+](CC(=O)Nc2ccccc2Oc2ccccc2)C1 by removing a amide.,C[C@H](O)[C@H]1CCC[NH+](CC(=O)Nc2ccccc2Oc2ccccc2)C1,amide
33883,Modify the molecule Cc1occc1-c1nnc(SCC(=O)Nc2ccccc2Cl)n1C[C@H]1CCCO1 by removing a benzene_ring.,Cc1occc1-c1nnc(SCC(=O)Nc2ccccc2Cl)n1C[C@H]1CCCO1,benzene_ring
176031,Modify the molecule CCN1CC(=O)N(CC(C)(C)C(=O)NN)CC1=O by removing a amide.,CCN1CC(=O)N(CC(C)(C)C(=O)NN)CC1=O,amide
44981,Modify the molecule Cn1c(=O)/c(=C\c2ccsc2)s/c1=C(\C#N)C(=O)c1ccccc1F by removing a halo.,Cn1c(=O)/c(=C\c2ccsc2)s/c1=C(\C#N)C(=O)c1ccccc1F,halo
76354,Modify the molecule COC(=O)C[C@@H](C[NH3+])c1ccccc1OC by removing a benzene_ring.,COC(=O)C[C@@H](C[NH3+])c1ccccc1OC,benzene_ring
6684,Remove a benzene_ring from the molecule O=C(NCc1ccc(F)c(Cl)c1)NC[C@@H]1CCCN(c2ncccn2)C1.,O=C(NCc1ccc(F)c(Cl)c1)NC[C@@H]1CCCN(c2ncccn2)C1,benzene_ring
96882,Modify the molecule c1ccc(CN2CC[C@@H](c3nc(-c4ccncc4)no3)C2)cc1 by removing a benzene_ring.,c1ccc(CN2CC[C@@H](c3nc(-c4ccncc4)no3)C2)cc1,benzene_ring
94261,Please remove a hydroxyl from the molecule CC1CCC(N2C[C@@H](C(=O)N[C@H](CO)c3ccco3)CC2=O)CC1.,CC1CCC(N2C[C@@H](C(=O)N[C@H](CO)c3ccco3)CC2=O)CC1,hydroxyl
234733,Remove a benzene_ring from the molecule C[NH+](Cc1nccn1Cc1ccccc1)[C@H]1CCCC[C@@H]1O.,C[NH+](Cc1nccn1Cc1ccccc1)[C@H]1CCCC[C@@H]1O,benzene_ring
58292,Please remove a amide from the molecule CC1CCC(NC(=O)C(=O)Nc2ccccc2C[NH+]2CCCC2)CC1.,CC1CCC(NC(=O)C(=O)Nc2ccccc2C[NH+]2CCCC2)CC1,amide
197264,Please remove a benzene_ring from the molecule Cc1c(CCC(=O)N(C)[C@H](C)Cc2ccc(O)cc2)cnn1C.,Cc1c(CCC(=O)N(C)[C@H](C)Cc2ccc(O)cc2)cnn1C,benzene_ring
132486,Modify the molecule Cc1cc(-n2c(C)cc(/C=C/C(=O)Nc3cccc(C(N)=O)c3)c2C)no1 by removing a amide.,Cc1cc(-n2c(C)cc(/C=C/C(=O)Nc3cccc(C(N)=O)c3)c2C)no1,amide
74660,Modify the molecule C[C@H]1CCC[C@H]([C@H](O)C2(C#N)CCC2)C1 by removing a hydroxyl.,C[C@H]1CCC[C@H]([C@H](O)C2(C#N)CCC2)C1,hydroxyl
102177,Remove a amide from the molecule Cc1cccc2nc(C(=O)N3CCC[C@@H](C(=O)[O-])C3)cn12.,Cc1cccc2nc(C(=O)N3CCC[C@@H](C(=O)[O-])C3)cn12,amide
246363,Remove a benzene_ring from the molecule Cc1ccccc1CC[NH2+]C[C@H](C#N)c1ccccc1.,Cc1ccccc1CC[NH2+]C[C@H](C#N)c1ccccc1,benzene_ring
62029,Please remove a amide from the molecule COc1ccc([C@@H]2SCC(=O)N2c2ccccc2)cc1OC.,COc1ccc([C@@H]2SCC(=O)N2c2ccccc2)cc1OC,amide
10329,Please remove a amide from the molecule C#CC[NH2+]CC(=O)Nc1ccc(F)cc1C(=O)[O-].,C#CC[NH2+]CC(=O)Nc1ccc(F)cc1C(=O)[O-],amide
175396,Modify the molecule CCn1cc(NC(=O)[C@H]2CSCN2C(=O)CC(C)(C)C)ccc1=O by removing a amide.,CCn1cc(NC(=O)[C@H]2CSCN2C(=O)CC(C)(C)C)ccc1=O,amide
189172,Modify the molecule CC[C@H](C)[NH2+]Cc1ccc(-c2ccccc2)o1 by removing a benzene_ring.,CC[C@H](C)[NH2+]Cc1ccc(-c2ccccc2)o1,benzene_ring
148253,Please remove a benzene_ring from the molecule Cc1cc(C)cc(N2C(=O)N(Cc3cccc(Cl)c3)[C@H]3CS(=O)(=O)C[C@H]32)c1.,Cc1cc(C)cc(N2C(=O)N(Cc3cccc(Cl)c3)[C@H]3CS(=O)(=O)C[C@H]32)c1,benzene_ring
58240,Remove a amide from the molecule CCC(C)(C)NC(=O)[C@H](C)[S@@](=O)Cc1ccc(C(=O)NC)cc1.,CCC(C)(C)NC(=O)[C@H](C)[S@@](=O)Cc1ccc(C(=O)NC)cc1,amide
203939,Remove a amine from the molecule CC(C)C[NH+]1CCn2nc(CNC(=O)Cc3csc4[n+]3CCN4)cc2C1.,CC(C)C[NH+]1CCn2nc(CNC(=O)Cc3csc4[n+]3CCN4)cc2C1,amine
171694,Modify the molecule [NH2+]=c1oc2ccc(Cl)cc2cc1C(=O)Nc1ccc(Cl)cc1Cl by removing a amide.,[NH2+]=c1oc2ccc(Cl)cc2cc1C(=O)Nc1ccc(Cl)cc1Cl,amide
206565,Remove a benzene_ring from the molecule O=C(Cc1nnc(NC(=O)Nc2ccccc2)s1)N/N=C/c1cccs1.,O=C(Cc1nnc(NC(=O)Nc2ccccc2)s1)N/N=C/c1cccs1,benzene_ring
130365,Please remove a benzene_ring from the molecule O=C(NCCC(=O)N1CCN(C[C@H]2CCCO2)CC1)c1ccc(Br)cc1.,O=C(NCCC(=O)N1CCN(C[C@H]2CCCO2)CC1)c1ccc(Br)cc1,benzene_ring
192894,Modify the molecule O=C(NC[C@H](c1ccc2c(c1)OCO2)N1CCOCC1)C(=O)Nc1ccccc1F by removing a benzene_ring.,O=C(NC[C@H](c1ccc2c(c1)OCO2)N1CCOCC1)C(=O)Nc1ccccc1F,benzene_ring
139730,Please remove a benzene_ring from the molecule CC(C)[C@@H](CO)NC(=O)NCc1ccccc1OC(C)(C)C.,CC(C)[C@@H](CO)NC(=O)NCc1ccccc1OC(C)(C)C,benzene_ring
145611,Remove a benzene_ring from the molecule CCn1nc(C)c(CN2CC[NH+](Cc3ccccc3)C[C@H]2C)c1C.,CCn1nc(C)c(CN2CC[NH+](Cc3ccccc3)C[C@H]2C)c1C,benzene_ring
205308,Please remove a amide from the molecule COc1ccc(OC)c([C@H]2CCC[NH+]2[C@H](C)C(=O)Nc2ccc(C(C)=O)cc2)c1.,COc1ccc(OC)c([C@H]2CCC[NH+]2[C@H](C)C(=O)Nc2ccc(C(C)=O)cc2)c1,amide
50236,Remove a benzene_ring from the molecule COc1ccc(-n2nc(C(=O)N3CCC([C@@H](C)O)CC3)cc2C)cc1.,COc1ccc(-n2nc(C(=O)N3CCC([C@@H](C)O)CC3)cc2C)cc1,benzene_ring
198714,Please remove a amide from the molecule CCOC(=O)C1CCN(C(=O)C2(c3cc(-c4ccc(Cl)cc4)on3)CC2)CC1.,CCOC(=O)C1CCN(C(=O)C2(c3cc(-c4ccc(Cl)cc4)on3)CC2)CC1,amide
202409,Remove a amide from the molecule Cc1nn(C(C)C)c(C)c1NC(=O)[C@H]1CCCN(c2ncccn2)C1.,Cc1nn(C(C)C)c(C)c1NC(=O)[C@H]1CCCN(c2ncccn2)C1,amide
94743,Modify the molecule CCCC(=O)c1ccn(C[C@H](C)C(N)=O)c1 by removing a amide.,CCCC(=O)c1ccn(C[C@H](C)C(N)=O)c1,amide
138671,Please remove a benzene_ring from the molecule CS(=O)(=O)c1ccc2nc([N-]S(=O)(=O)c3ccc(I)cc3)sc2c1.,CS(=O)(=O)c1ccc2nc([N-]S(=O)(=O)c3ccc(I)cc3)sc2c1,benzene_ring
82248,Please remove a hydroxyl from the molecule CC[C@@H](O)C[NH+](Cc1ccco1)C[C@@H]1CCCO1.,CC[C@@H](O)C[NH+](Cc1ccco1)C[C@@H]1CCCO1,hydroxyl
121866,Please remove a benzene_ring from the molecule COc1ccc(-c2ccc(C(=O)[O-])c(N)c2)cc1.,COc1ccc(-c2ccc(C(=O)[O-])c(N)c2)cc1,benzene_ring
17260,Modify the molecule O=C(CCSc1nc2ccccc2s1)Nc1ccc2oc(=O)[nH]c2c1 by removing a amide.,O=C(CCSc1nc2ccccc2s1)Nc1ccc2oc(=O)[nH]c2c1,amide
227098,Please remove a amide from the molecule COc1ccc(C(=O)NCc2ccccc2OCC(C)C)nn1.,COc1ccc(C(=O)NCc2ccccc2OCC(C)C)nn1,amide
175173,Please remove a amide from the molecule Cc1nc2ccccc2n1CCNC(=O)c1cc(Cl)cc(Cl)c1.,Cc1nc2ccccc2n1CCNC(=O)c1cc(Cl)cc(Cl)c1,amide
137241,Please remove a benzene_ring from the molecule O=C([O-])[C@H]1CC=CC[C@H]1C(=O)Nc1ccc(S(=O)(=O)N2CCc3ccccc32)cc1.,O=C([O-])[C@H]1CC=CC[C@H]1C(=O)Nc1ccc(S(=O)(=O)N2CCc3ccccc32)cc1,benzene_ring
224488,Remove a benzene_ring from the molecule CCCCN(C(=O)Cn1nc2ccccn2c1=O)[C@@H](C)c1ccccc1.,CCCCN(C(=O)Cn1nc2ccccn2c1=O)[C@@H](C)c1ccccc1,benzene_ring
191067,Modify the molecule O=C(CNc1ccc(C(F)(F)F)cc1Cl)NC(=O)NC1CC1 by removing a amide.,O=C(CNc1ccc(C(F)(F)F)cc1Cl)NC(=O)NC1CC1,amide
9096,Remove a amide from the molecule CCOC(=O)[C@]12C(=C(c3ccccc3)O[C@@H]3C=CCC[C@H]31)C(=O)C(=O)N2c1ccccc1.,CCOC(=O)[C@]12C(=C(c3ccccc3)O[C@@H]3C=CCC[C@H]31)C(=O)C(=O)N2c1ccccc1,amide
54463,Remove a benzene_ring from the molecule Cc1cccc(C)c1NC(=O)C[NH2+][C@H](C)Cn1cnc(C)c1C.,Cc1cccc(C)c1NC(=O)C[NH2+][C@H](C)Cn1cnc(C)c1C,benzene_ring
77400,Modify the molecule O=C(c1ccc([N+](=O)[O-])o1)N(Cc1ccccn1)c1ccc(F)cc1 by removing a amide.,O=C(c1ccc([N+](=O)[O-])o1)N(Cc1ccccn1)c1ccc(F)cc1,amide
133004,Remove a halo from the molecule COC(=O)C1=C(C)Nc2[nH]c(=S)[nH]c(=O)c2[C@H]1c1ccccc1Cl.,COC(=O)C1=C(C)Nc2[nH]c(=S)[nH]c(=O)c2[C@H]1c1ccccc1Cl,halo
94170,Please remove a hydroxyl from the molecule COc1cc(C[NH+]2CCC([C@H](O)c3nccn3C)CC2)cc(OC)c1.,COc1cc(C[NH+]2CCC([C@H](O)c3nccn3C)CC2)cc(OC)c1,hydroxyl
95953,Please remove a benzene_ring from the molecule Cc1nc2c(-c3cccs3)nc(=O)n(Cc3ccc(Cl)cc3Cl)c2s1.,Cc1nc2c(-c3cccs3)nc(=O)n(Cc3ccc(Cl)cc3Cl)c2s1,benzene_ring
167181,Please remove a benzene_ring from the molecule CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)N(Cc1ccccc1F)C1CC1.,CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)N(Cc1ccccc1F)C1CC1,benzene_ring
108174,Remove a amide from the molecule CC(=O)Nc1cccc(-n2c(C)nn(C[C@H](O)c3ccccc3)c2=S)c1.,CC(=O)Nc1cccc(-n2c(C)nn(C[C@H](O)c3ccccc3)c2=S)c1,amide
87586,Modify the molecule CCOc1ccc(C(=O)c2ccc(F)cc2)cc1OCC by removing a halo.,CCOc1ccc(C(=O)c2ccc(F)cc2)cc1OCC,halo
54995,Modify the molecule Cc1c(C)c(C)c([C@@H]([NH3+])CO)c(C)c1C by removing a hydroxyl.,Cc1c(C)c(C)c([C@@H]([NH3+])CO)c(C)c1C,hydroxyl
174962,Please remove a amide from the molecule O=C(c1cccc([N+](=O)[O-])c1)N1CCN=C1SCc1cccc(C(F)(F)F)c1.,O=C(c1cccc([N+](=O)[O-])c1)N1CCN=C1SCc1cccc(C(F)(F)F)c1,amide
131876,Remove a amide from the molecule COc1cccc(C(=O)N2CCN(C(=O)CCc3cccnc3)CC2)c1.,COc1cccc(C(=O)N2CCN(C(=O)CCc3cccnc3)CC2)c1,amide
239527,Please remove a benzene_ring from the molecule O=C(N1CCC(NS(=O)(=O)c2ccc(Cl)cc2)CC1)C1(c2ccccc2)CC1.,O=C(N1CCC(NS(=O)(=O)c2ccc(Cl)cc2)CC1)C1(c2ccccc2)CC1,benzene_ring
156628,Remove a nitro from the molecule Cc1ccc(NCc2ccc(C3CC3)cc2)cc1[N+](=O)[O-].,Cc1ccc(NCc2ccc(C3CC3)cc2)cc1[N+](=O)[O-],nitro
83277,Remove a nitrile from the molecule Cc1cccc(C)c1OCC(=O)[C@H](C#N)c1nnc(-c2ccccc2)n1C.,Cc1cccc(C)c1OCC(=O)[C@H](C#N)c1nnc(-c2ccccc2)n1C,nitrile
227288,Remove a benzene_ring from the molecule CCOc1ccc(S(=O)(=O)Nc2ccc3c(c2)N(CC(C)C)C(=O)C(C)(C)CO3)cc1.,CCOc1ccc(S(=O)(=O)Nc2ccc3c(c2)N(CC(C)C)C(=O)C(C)(C)CO3)cc1,benzene_ring
34754,Please remove a halo from the molecule CCn1cc(Br)c(CN(C)S(=O)(=O)c2cnn(CC)c2C)n1.,CCn1cc(Br)c(CN(C)S(=O)(=O)c2cnn(CC)c2C)n1,halo
48985,Remove a halo from the molecule C[C@H](Cc1ccccc1F)C(=O)N[C@H]1CCS(=O)(=O)C1.,C[C@H](Cc1ccccc1F)C(=O)N[C@H]1CCS(=O)(=O)C1,halo
39577,Remove a benzene_ring from the molecule CC[C@H](CSC)NC(=O)NCCc1ccccc1C.,CC[C@H](CSC)NC(=O)NCCc1ccccc1C,benzene_ring
36877,Modify the molecule Cc1cc(C)n(-c2ccc(C(=O)N(C)[C@@H]3CCC[C@H](C)C3)cn2)n1 by removing a amide.,Cc1cc(C)n(-c2ccc(C(=O)N(C)[C@@H]3CCC[C@H](C)C3)cn2)n1,amide
165531,Please remove a benzene_ring from the molecule Cc1cc(C)c(NC(=O)c2cccc(NC(=O)c3ccco3)c2)c(C)c1.,Cc1cc(C)c(NC(=O)c2cccc(NC(=O)c3ccco3)c2)c(C)c1,benzene_ring
81436,Modify the molecule CCc1ccc(NC(=O)Cc2csc(COc3cccc(C)c3)n2)cc1 by removing a amide.,CCc1ccc(NC(=O)Cc2csc(COc3cccc(C)c3)n2)cc1,amide
55864,Please remove a benzene_ring from the molecule CCC(CC)S(=O)(=O)/N=C(\[O-])c1ccc(N2CCOCC2)c(F)c1.,CCC(CC)S(=O)(=O)/N=C(\[O-])c1ccc(N2CCOCC2)c(F)c1,benzene_ring
34252,Remove a amide from the molecule CC(C)NC(=O)c1cccc2c1NC(=O)C2.,CC(C)NC(=O)c1cccc2c1NC(=O)C2,amide
231875,Remove a benzene_ring from the molecule CCOC(=O)C1CCN([C@H]2CS(=O)(=O)C[C@@H]2S(=O)(=O)c2ccc(OC)c(C)c2)CC1.,CCOC(=O)C1CCN([C@H]2CS(=O)(=O)C[C@@H]2S(=O)(=O)c2ccc(OC)c(C)c2)CC1,benzene_ring
121147,Modify the molecule Cc1c(Cl)cccc1-n1ccc2nc(N3CCCCC3)ncc2c1=O by removing a benzene_ring.,Cc1c(Cl)cccc1-n1ccc2nc(N3CCCCC3)ncc2c1=O,benzene_ring
70297,Please remove a halo from the molecule O=C(NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1)N1CCC2(CC1)OCCO2.,O=C(NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1)N1CCC2(CC1)OCCO2,halo
20542,Remove a amide from the molecule Cc1cnc(C(=O)NCc2cnn(Cc3ccccc3)c2)cn1.,Cc1cnc(C(=O)NCc2cnn(Cc3ccccc3)c2)cn1,amide
218115,Modify the molecule C[C@H](NC(=O)CCc1nc(-c2ccccn2)no1)c1ccc2c(c1)CCCO2 by removing a amide.,C[C@H](NC(=O)CCc1nc(-c2ccccn2)no1)c1ccc2c(c1)CCCO2,amide
225473,Modify the molecule CC[C@H](C)[C@@H](NC(=O)/C=C/c1csc(C)n1)C(=O)[O-] by removing a amide.,CC[C@H](C)[C@@H](NC(=O)/C=C/c1csc(C)n1)C(=O)[O-],amide
111107,Please remove a hydroxyl from the molecule Cc1ccc[nH+]c1N1CCN(C(=O)C[NH+]2CCC[C@H](O)C2)CC1.,Cc1ccc[nH+]c1N1CCN(C(=O)C[NH+]2CCC[C@H](O)C2)CC1,hydroxyl
72539,Please remove a halo from the molecule FC(F)(F)c1ccccc1N[C@H]1CCO[C@]2(CCSC2)C1.,FC(F)(F)c1ccccc1N[C@H]1CCO[C@]2(CCSC2)C1,halo
215394,Modify the molecule COc1ccc(-c2nnsc2C(=O)Nc2ccc(Br)cc2F)cc1 by removing a benzene_ring.,COc1ccc(-c2nnsc2C(=O)Nc2ccc(Br)cc2F)cc1,benzene_ring
137755,Please remove a benzene_ring from the molecule CCOc1ccccc1NC(=O)NC[C@H](O)c1ccccc1F.,CCOc1ccccc1NC(=O)NC[C@H](O)c1ccccc1F,benzene_ring
246819,Modify the molecule Cc1ccc(Cl)cc1NC(=O)c1ccc(-n2ccnc2)cc1 by removing a benzene_ring.,Cc1ccc(Cl)cc1NC(=O)c1ccc(-n2ccnc2)cc1,benzene_ring
169121,Remove a amide from the molecule Cc1cc(C(=O)Nc2nnc(C3CCCCC3)s2)no1.,Cc1cc(C(=O)Nc2nnc(C3CCCCC3)s2)no1,amide
89966,Modify the molecule CN(c1nc2ccc([N+](=O)[O-])cc2o1)[C@@H]1CC[NH2+]C1 by removing a nitro.,CN(c1nc2ccc([N+](=O)[O-])cc2o1)[C@@H]1CC[NH2+]C1,nitro
167311,Please remove a amide from the molecule COc1ccccc1N1CC[NH+](C/C=C\c2ccc3c(c2)CCC(=O)N3)CC1.,COc1ccccc1N1CC[NH+](C/C=C\c2ccc3c(c2)CCC(=O)N3)CC1,amide
151009,Modify the molecule CC1(C)NC(=O)N(CC(=O)NCCc2nc3ccccc3[nH]2)C1=O by removing a amide.,CC1(C)NC(=O)N(CC(=O)NCCc2nc3ccccc3[nH]2)C1=O,amide
164175,Modify the molecule CCOc1ccc(NC(=O)CN2CC[NH+]([C@@H]3CC[C@H](CC)C3)CC2)cc1 by removing a benzene_ring.,CCOc1ccc(NC(=O)CN2CC[NH+]([C@@H]3CC[C@H](CC)C3)CC2)cc1,benzene_ring
49848,Remove a benzene_ring from the molecule Cc1cc(NC(=O)Nc2ccccc2)c2ccccc2n1.,Cc1cc(NC(=O)Nc2ccccc2)c2ccccc2n1,benzene_ring
61815,Please remove a benzene_ring from the molecule C[C@@H]1CC(Nc2cccc(Oc3cnccn3)c2)C[C@@H](C)O1.,C[C@@H]1CC(Nc2cccc(Oc3cnccn3)c2)C[C@@H](C)O1,benzene_ring
107109,Modify the molecule CCN(c1ccccc1[C@H](C)[NH3+])C(C)C by removing a benzene_ring.,CCN(c1ccccc1[C@H](C)[NH3+])C(C)C,benzene_ring
62605,Modify the molecule CC(=O)NC12C[C@H]3C[C@@H](C1)CC(C(=O)NCCCC1CCCC1)(C3)C2 by removing a amide.,CC(=O)NC12C[C@H]3C[C@@H](C1)CC(C(=O)NCCCC1CCCC1)(C3)C2,amide
16629,Remove a amine from the molecule CC1(C)S[C@@H](c2ncc(-c3cccs3)s2)N[C@@H]1C(=O)[O-].,CC1(C)S[C@@H](c2ncc(-c3cccs3)s2)N[C@@H]1C(=O)[O-],amine
181279,Please remove a benzene_ring from the molecule O=C(NCC[C@H]1CCCO1)c1ccc(Cl)cc1F.,O=C(NCC[C@H]1CCCO1)c1ccc(Cl)cc1F,benzene_ring
144154,Please remove a amide from the molecule CCN1C(=O)c2ccc(Cl)cc2N[C@@H]1c1ccccc1[N+](=O)[O-].,CCN1C(=O)c2ccc(Cl)cc2N[C@@H]1c1ccccc1[N+](=O)[O-],amide
26350,Please remove a amide from the molecule C[NH+]1CCN(C(=O)c2ccccc2NC(=S)NC(=O)c2ccco2)CC1.,C[NH+]1CCN(C(=O)c2ccccc2NC(=S)NC(=O)c2ccco2)CC1,amide
184584,Remove a amine from the molecule C[C@H]1C[C@H](N)C[NH+](Cc2nnc(C(C)(C)C)o2)C1.,C[C@H]1C[C@H](N)C[NH+](Cc2nnc(C(C)(C)C)o2)C1,amine
97804,Modify the molecule Cn1[nH]c(-c2ccc(Oc3ccccc3)cc2)cc1=O by removing a benzene_ring.,Cn1[nH]c(-c2ccc(Oc3ccccc3)cc2)cc1=O,benzene_ring
74158,Please remove a amine from the molecule Cc1cc2c(c(=O)n1CCc1ccccc1)[C@H](c1ccc([N+](=O)[O-])o1)C(C#N)=C(N)O2.,Cc1cc2c(c(=O)n1CCc1ccccc1)[C@H](c1ccc([N+](=O)[O-])o1)C(C#N)=C(N)O2,amine
84716,Remove a benzene_ring from the molecule CCOC(=O)c1cccc(NC(=O)N[C@@H](C)c2ccc(C)o2)c1.,CCOC(=O)c1cccc(NC(=O)N[C@@H](C)c2ccc(C)o2)c1,benzene_ring
151627,Remove a amide from the molecule COc1ccnc(NC(=O)[C@]2(C)CC2(Cl)Cl)c1.,COc1ccnc(NC(=O)[C@]2(C)CC2(Cl)Cl)c1,amide
155885,Please remove a benzene_ring from the molecule C[C@@H]([NH3+])c1cc(F)ccc1OCC[C@@H]1CCCO1.,C[C@@H]([NH3+])c1cc(F)ccc1OCC[C@@H]1CCCO1,benzene_ring
105199,Modify the molecule C[C@H]1OCC[C@@H]1Nc1ccc(OC(F)F)cn1 by removing a halo.,C[C@H]1OCC[C@@H]1Nc1ccc(OC(F)F)cn1,halo
66983,Please remove a halo from the molecule O=C(CCn1ccc2c(Cl)cccc21)NCc1nnc2ccccn12.,O=C(CCn1ccc2c(Cl)cccc21)NCc1nnc2ccccn12,halo
11089,Please remove a amide from the molecule C[C@H]1C[NH+](Cc2ccccc2)CCCN1C(=O)CCn1ccccc1=O.,C[C@H]1C[NH+](Cc2ccccc2)CCCN1C(=O)CCn1ccccc1=O,amide
210144,Remove a amine from the molecule Cc1ccccc1C(=O)OCCn1c(N)c(S(=O)(=O)c2ccccc2)c2nc3ccccc3nc21.,Cc1ccccc1C(=O)OCCn1c(N)c(S(=O)(=O)c2ccccc2)c2nc3ccccc3nc21,amine
232147,Please remove a amine from the molecule COC[C@@H](N[C@H](C)c1nc2c(s1)CCCC2)c1ccco1.,COC[C@@H](N[C@H](C)c1nc2c(s1)CCCC2)c1ccco1,amine
84521,Modify the molecule Cc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC[C@H]([NH+]6CCCCC6)C5)c34)cnn2C)cc1 by removing a benzene_ring.,Cc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC[C@H]([NH+]6CCCCC6)C5)c34)cnn2C)cc1,benzene_ring
192188,Remove a hydroxyl from the molecule COc1ccc([C@@H]2OC(=O)N(C)[C@@]2(O)c2ccc(OC)cc2)cc1.,COc1ccc([C@@H]2OC(=O)N(C)[C@@]2(O)c2ccc(OC)cc2)cc1,hydroxyl
113395,Modify the molecule CC[C@H](NC(=O)CC[C@H]1CCCOC1)c1cccc([N+](=O)[O-])c1 by removing a benzene_ring.,CC[C@H](NC(=O)CC[C@H]1CCCOC1)c1cccc([N+](=O)[O-])c1,benzene_ring
233028,Remove a halo from the molecule Cc1ccc(NC(=O)C(=O)NC[C@H](c2cccn2C)[NH+](C)C)cc1F.,Cc1ccc(NC(=O)C(=O)NC[C@H](c2cccn2C)[NH+](C)C)cc1F,halo
158958,Please remove a halo from the molecule C[C@@H](Sc1nccn1C)C(=O)Nc1ccc(OC(F)F)c(Cl)c1.,C[C@@H](Sc1nccn1C)C(=O)Nc1ccc(OC(F)F)c(Cl)c1,halo
96852,Modify the molecule CC(C)(C)c1csc(CN2CCN(C(=O)/C=C/c3ccc4c(c3)OCO4)CC2)n1 by removing a amide.,CC(C)(C)c1csc(CN2CCN(C(=O)/C=C/c3ccc4c(c3)OCO4)CC2)n1,amide
68702,Please remove a amine from the molecule Nc1ccccc1NC(=O)N[C@H]1CCOC1.,Nc1ccccc1NC(=O)N[C@H]1CCOC1,amine
71723,Remove a amide from the molecule COc1ccccc1/C=C/C(=O)N1CCC(NS(C)(=O)=O)CC1.,COc1ccccc1/C=C/C(=O)N1CCC(NS(C)(=O)=O)CC1,amide
82222,Modify the molecule Cc1ccc([C@@]2(C)NC(=O)N(CC(=O)N(C3CCCC3)[C@@H]3CCS(=O)(=O)C3)C2=O)cc1 by removing a benzene_ring.,Cc1ccc([C@@]2(C)NC(=O)N(CC(=O)N(C3CCCC3)[C@@H]3CCS(=O)(=O)C3)C2=O)cc1,benzene_ring
145879,Modify the molecule O=C(Cc1c(Cl)cccc1Cl)C[C@@H]1C[C@H]2CC[C@@H]1C2 by removing a benzene_ring.,O=C(Cc1c(Cl)cccc1Cl)C[C@@H]1C[C@H]2CC[C@@H]1C2,benzene_ring
91508,Remove a benzene_ring from the molecule COc1ccc(F)c(NC(=O)NCc2ccc3c(c2)CCC3)c1.,COc1ccc(F)c(NC(=O)NCc2ccc3c(c2)CCC3)c1,benzene_ring
248955,Please remove a benzene_ring from the molecule S=C(CC12CC3CC(CC(C3)C1)C2)N1CCN(c2ccccc2)CC1.,S=C(CC12CC3CC(CC(C3)C1)C2)N1CCN(c2ccccc2)CC1,benzene_ring
248337,Please remove a benzene_ring from the molecule Cc1noc(C)c1S(=O)(=O)Nc1cccc(-c2ccc(=O)n(C)n2)c1.,Cc1noc(C)c1S(=O)(=O)Nc1cccc(-c2ccc(=O)n(C)n2)c1,benzene_ring
115988,Please remove a benzene_ring from the molecule O=c1c2cc([N+](=O)[O-])ccc2ncn1Cc1cccc(Cl)c1.,O=c1c2cc([N+](=O)[O-])ccc2ncn1Cc1cccc(Cl)c1,benzene_ring
233689,Modify the molecule O=C(c1ccccc1-c1ccccc1)N1CCC[NH+](C[C@H]2CCCO2)CC1 by removing a benzene_ring.,O=C(c1ccccc1-c1ccccc1)N1CCC[NH+](C[C@H]2CCCO2)CC1,benzene_ring
91396,Modify the molecule Cc1ccc(C)c(NC(=O)[C@@H](C)S(=O)(=O)[C@@H](C)C(C)C)c1 by removing a amide.,Cc1ccc(C)c(NC(=O)[C@@H](C)S(=O)(=O)[C@@H](C)C(C)C)c1,amide
109839,Please remove a amide from the molecule N#CCNC(=O)C[NH+]1CCCN(S(=O)(=O)c2ccc(F)cc2)CC1.,N#CCNC(=O)C[NH+]1CCCN(S(=O)(=O)c2ccc(F)cc2)CC1,amide
150489,Remove a benzene_ring from the molecule Cc1ccccc1NC(=O)c1c(C)nc(Nc2nc3ccccc3o2)nc1C.,Cc1ccccc1NC(=O)c1c(C)nc(Nc2nc3ccccc3o2)nc1C,benzene_ring
27465,Remove a halo from the molecule COc1cc(Br)c(N)c(C(=O)[O-])c1.,COc1cc(Br)c(N)c(C(=O)[O-])c1,halo
144011,Modify the molecule Cc1ccc(NC(=O)c2ccccc2C)c(Nc2ccco2)c1 by removing a amine.,Cc1ccc(NC(=O)c2ccccc2C)c(Nc2ccco2)c1,amine
57009,Modify the molecule Cc1cc(C)cc(N2CC[C@H](NC(=O)c3cc(F)ccc3F)C2=O)c1 by removing a benzene_ring.,Cc1cc(C)cc(N2CC[C@H](NC(=O)c3cc(F)ccc3F)C2=O)c1,benzene_ring
24225,Modify the molecule C[C@@H](CC(=O)N1CCN(S(=O)(=O)c2cccc(Cl)c2Cl)CC1)c1ccccc1 by removing a benzene_ring.,C[C@@H](CC(=O)N1CCN(S(=O)(=O)c2cccc(Cl)c2Cl)CC1)c1ccccc1,benzene_ring
121713,Modify the molecule Cc1nnc(NC(=O)c2cc(=O)c3ccccc3o2)s1 by removing a amide.,Cc1nnc(NC(=O)c2cc(=O)c3ccccc3o2)s1,amide
2044,Remove a benzene_ring from the molecule COc1ccc(NC(=O)NCC(=O)[O-])cc1Cl.,COc1ccc(NC(=O)NCC(=O)[O-])cc1Cl,benzene_ring
101555,Please remove a benzene_ring from the molecule CC[C@H](NC(=O)Nc1ccn(C)n1)c1ccc(C)cc1.,CC[C@H](NC(=O)Nc1ccn(C)n1)c1ccc(C)cc1,benzene_ring
48932,Please remove a benzene_ring from the molecule Cc1cccc(N2C(=O)[C@@H]3[C@H](c4ccccc4)OC4(C(=O)c5ccccc5C4=O)[C@@H]3C2=O)c1C.,Cc1cccc(N2C(=O)[C@@H]3[C@H](c4ccccc4)OC4(C(=O)c5ccccc5C4=O)[C@@H]3C2=O)c1C,benzene_ring
229011,Remove a benzene_ring from the molecule COc1cc(C#N)ccc1OCC(=O)Nc1ccc(C(C)=O)cc1.,COc1cc(C#N)ccc1OCC(=O)Nc1ccc(C(C)=O)cc1,benzene_ring
156761,Modify the molecule CC(C)c1ccc([C@@H](Cl)[C@H](C)c2ccccn2)cc1 by removing a benzene_ring.,CC(C)c1ccc([C@@H](Cl)[C@H](C)c2ccccn2)cc1,benzene_ring
52847,Modify the molecule N=[S@](N)c1cnc(N)s1 by removing a amine.,N=[S@](N)c1cnc(N)s1,amine
30339,Modify the molecule C=CCNc1ccc([N+](=O)[O-])c(N)n1 by removing a nitro.,C=CCNc1ccc([N+](=O)[O-])c(N)n1,nitro
158546,Please remove a amine from the molecule Nc1ccc(F)cc1NC(=O)COCc1ccco1.,Nc1ccc(F)cc1NC(=O)COCc1ccco1,amine
192015,Modify the molecule CC1CC[NH+](CCNC(=O)C(=O)Nc2cc(F)cc(F)c2)CC1 by removing a halo.,CC1CC[NH+](CCNC(=O)C(=O)Nc2cc(F)cc(F)c2)CC1,halo
125566,Modify the molecule Cc1cc(F)ccc1CCNC(=O)NCCCn1nc2n(c1=O)CCCC2 by removing a benzene_ring.,Cc1cc(F)ccc1CCNC(=O)NCCCn1nc2n(c1=O)CCCC2,benzene_ring
122996,Modify the molecule COc1ccccc1OC(=O)CCc1c(C)nc(-c2cccnc2)[nH]c1=O by removing a benzene_ring.,COc1ccccc1OC(=O)CCc1c(C)nc(-c2cccnc2)[nH]c1=O,benzene_ring
101683,Modify the molecule COc1cc([C@@H]2NC(=O)N(C)[C@@](O)(C(F)(F)F)[C@H]2C(=O)c2cccs2)cc(OC)c1OC by removing a halo.,COc1cc([C@@H]2NC(=O)N(C)[C@@](O)(C(F)(F)F)[C@H]2C(=O)c2cccs2)cc(OC)c1OC,halo
188342,Modify the molecule O=C(NCc1cccnc1)C(F)(F)F by removing a amide.,O=C(NCc1cccnc1)C(F)(F)F,amide
221211,Remove a amide from the molecule Cn1c(SCC(=O)Nc2ccc3c(c2)OCCO3)nc2c([nH]c3ccccc32)c1=O.,Cn1c(SCC(=O)Nc2ccc3c(c2)OCCO3)nc2c([nH]c3ccccc32)c1=O,amide
66973,Please remove a hydroxyl from the molecule Oc1ccc(-c2nc3ccccc3s2)cc1Cl.,Oc1ccc(-c2nc3ccccc3s2)cc1Cl,hydroxyl
12689,Please remove a benzene_ring from the molecule Cc1cc(C)cc(C(=O)N2CC[C@H](C(=O)[O-])[C@@H]2C)c1.,Cc1cc(C)cc(C(=O)N2CC[C@H](C(=O)[O-])[C@@H]2C)c1,benzene_ring
204060,Modify the molecule Cc1cn(-c2ccccc2Cl)nc1NC(=O)C(=O)NCCCC(C)(C)C by removing a benzene_ring.,Cc1cn(-c2ccccc2Cl)nc1NC(=O)C(=O)NCCCC(C)(C)C,benzene_ring
119770,Please remove a benzene_ring from the molecule O=C(NC1CCN(c2ncc(Cl)cc2F)CC1)c1ccccc1F.,O=C(NC1CCN(c2ncc(Cl)cc2F)CC1)c1ccccc1F,benzene_ring
4401,Remove a benzene_ring from the molecule COc1cccc([C@H]2C[C@H]2C(=O)Oc2cccc(-n3cccn3)c2)c1.,COc1cccc([C@H]2C[C@H]2C(=O)Oc2cccc(-n3cccn3)c2)c1,benzene_ring
133645,Modify the molecule Cc1ccc2c(c1)cc(C(=O)N(Cc1ccccn1)C1CCCCC1)n2C by removing a amide.,Cc1ccc2c(c1)cc(C(=O)N(Cc1ccccn1)C1CCCCC1)n2C,amide
176505,Remove a benzene_ring from the molecule COc1ccc(N(C)S(=O)(=O)c2cccc(C(=O)N[C@H]3CCCC[C@H]3C)c2)cc1.,COc1ccc(N(C)S(=O)(=O)c2cccc(C(=O)N[C@H]3CCCC[C@H]3C)c2)cc1,benzene_ring
177509,Remove a halo from the molecule COc1ccc(N2CCN([C@H](c3ccccc3F)c3nnnn3C3CCCCC3)CC2)cc1.,COc1ccc(N2CCN([C@H](c3ccccc3F)c3nnnn3C3CCCCC3)CC2)cc1,halo
108441,Please remove a amide from the molecule Cc1cccc(NC(=O)c2cccc(NC(=O)C(C)(C)C)c2)c1C.,Cc1cccc(NC(=O)c2cccc(NC(=O)C(C)(C)C)c2)c1C,amide
92852,Remove a aldehyde from the molecule CC/C(C=O)=C\C1CCCCCC1.,CC/C(C=O)=C\C1CCCCCC1,aldehyde
1575,Modify the molecule Cc1nn(-c2ccccc2)c(C)c1S(=O)(=O)N1CCCCCC1 by removing a benzene_ring.,Cc1nn(-c2ccccc2)c(C)c1S(=O)(=O)N1CCCCCC1,benzene_ring
30720,Please remove a amine from the molecule CCN1C(N)=[NH+]C[C@@]1(C)c1ccc2cc(OC)ccc2c1.,CCN1C(N)=[NH+]C[C@@]1(C)c1ccc2cc(OC)ccc2c1,amine
204412,Remove a benzene_ring from the molecule Cc1ccc(C(=O)C(=O)N2CCOCC[C@H]2C)cc1.,Cc1ccc(C(=O)C(=O)N2CCOCC[C@H]2C)cc1,benzene_ring
225288,Please remove a amide from the molecule CCOc1ccc(CC(=O)Nc2ccc(S(N)(=O)=O)c(C)c2)cc1.,CCOc1ccc(CC(=O)Nc2ccc(S(N)(=O)=O)c(C)c2)cc1,amide
48714,Please remove a benzene_ring from the molecule CC[C@@H]1SC2=NC(C)=C(C(=O)OCC(C)C)[C@H](c3ccc(OC)cc3)N2C1=O.,CC[C@@H]1SC2=NC(C)=C(C(=O)OCC(C)C)[C@H](c3ccc(OC)cc3)N2C1=O,benzene_ring
212527,Modify the molecule O=C(Nc1ccc(N2CCN(C(=O)c3ccco3)CC2)cc1)c1ccc(-c2ccccc2[N+](=O)[O-])o1 by removing a nitro.,O=C(Nc1ccc(N2CCN(C(=O)c3ccco3)CC2)cc1)c1ccc(-c2ccccc2[N+](=O)[O-])o1,nitro
95756,Modify the molecule Cc1nc2c(sc3nc(-c4ccccc4)ccc32)c(=O)n1CC(=O)NCc1ccccc1 by removing a amide.,Cc1nc2c(sc3nc(-c4ccccc4)ccc32)c(=O)n1CC(=O)NCc1ccccc1,amide
45558,Please remove a halo from the molecule COc1cc(NC(=O)[C@@H]2CC(=O)N(C)C2)c(OC)cc1Cl.,COc1cc(NC(=O)[C@@H]2CC(=O)N(C)C2)c(OC)cc1Cl,halo
247821,Please remove a halo from the molecule Cc1nc(C(=O)N(C)Cc2ccc(C(F)(F)F)cc2)nn1-c1ccc(F)cc1.,Cc1nc(C(=O)N(C)Cc2ccc(C(F)(F)F)cc2)nn1-c1ccc(F)cc1,halo
197053,Please remove a halo from the molecule O=C(Cc1ccc(F)cc1)Nc1cccc(-c2cn3c(C(=O)N4CCOCC4)csc3n2)c1.,O=C(Cc1ccc(F)cc1)Nc1cccc(-c2cn3c(C(=O)N4CCOCC4)csc3n2)c1,halo
51403,Please remove a amide from the molecule CC(=O)N[C@H](c1nccs1)C1CCN(C(=O)c2c(C(C)C)noc2C)CC1.,CC(=O)N[C@H](c1nccs1)C1CCN(C(=O)c2c(C(C)C)noc2C)CC1,amide
234246,Modify the molecule Cc1cnn([C@@H]2CCCN(C(=O)CN3C(=O)CNC3=O)C2)c1 by removing a amide.,Cc1cnn([C@@H]2CCCN(C(=O)CN3C(=O)CNC3=O)C2)c1,amide
15707,Please remove a halo from the molecule CC(C)CCO[C@@H]1CCN(C(=O)[C@H](C)NC(=O)c2ccc(Cl)cc2)C1.,CC(C)CCO[C@@H]1CCN(C(=O)[C@H](C)NC(=O)c2ccc(Cl)cc2)C1,halo
94932,Modify the molecule O=C(Nc1cnn(-c2ccccc2F)c1)N1CCSCC1 by removing a benzene_ring.,O=C(Nc1cnn(-c2ccccc2F)c1)N1CCSCC1,benzene_ring
35884,Modify the molecule C[NH+](C)[C@@H]1CCCN(Cc2cc(C(N)=O)cs2)C1 by removing a amide.,C[NH+](C)[C@@H]1CCCN(Cc2cc(C(N)=O)cs2)C1,amide
129183,Remove a amide from the molecule C[C@@H](C(=O)Nc1ccc(Br)cc1Br)[NH+](C)C[C@@H]1COc2ccccc2O1.,C[C@@H](C(=O)Nc1ccc(Br)cc1Br)[NH+](C)C[C@@H]1COc2ccccc2O1,amide
36008,Modify the molecule O=C(Nc1ccccc1)C(=O)Nc1cc(-n2cccc2)ccc1F by removing a halo.,O=C(Nc1ccccc1)C(=O)Nc1cc(-n2cccc2)ccc1F,halo
193161,Modify the molecule C[C@H]1CN(c2cncc(C(N)=O)n2)CCO1 by removing a amide.,C[C@H]1CN(c2cncc(C(N)=O)n2)CCO1,amide
209011,Please remove a amide from the molecule COc1ccc(F)c(NC(=O)C(=O)NCCN(C)c2ccccc2)c1.,COc1ccc(F)c(NC(=O)C(=O)NCCN(C)c2ccccc2)c1,amide
26521,Please remove a benzene_ring from the molecule C=CCn1c(=O)c2c(nc3n2CCN3c2ccc(CC)cc2)n(C)c1=O.,C=CCn1c(=O)c2c(nc3n2CCN3c2ccc(CC)cc2)n(C)c1=O,benzene_ring
154525,Remove a amide from the molecule Cc1ccc(C2=C[C@H]([C@H]3NN[C@H](SCC(=O)Nc4cccc(C(F)(F)F)c4)N3N)N=N2)cc1.,Cc1ccc(C2=C[C@H]([C@H]3NN[C@H](SCC(=O)Nc4cccc(C(F)(F)F)c4)N3N)N=N2)cc1,amide
3056,Please remove a hydroxyl from the molecule CCC[NH2+]CC[NH+](C)CC(C)(C)O.,CCC[NH2+]CC[NH+](C)CC(C)(C)O,hydroxyl
5319,Please remove a hydroxyl from the molecule CC1(C)C[C@](O)([C@@H]2CCOC3(CCC3)C2)CCO1.,CC1(C)C[C@](O)([C@@H]2CCOC3(CCC3)C2)CCO1,hydroxyl
65375,Modify the molecule NC(=O)C1CCN(CCC[NH2+]Cc2ccc3ccccc3c2)CC1 by removing a amide.,NC(=O)C1CCN(CCC[NH2+]Cc2ccc3ccccc3c2)CC1,amide
231713,Modify the molecule C[C@H](NS(=O)(=O)c1cccc(F)c1)C(=O)N1CCCC1 by removing a amine.,C[C@H](NS(=O)(=O)c1cccc(F)c1)C(=O)N1CCCC1,amine
16480,Remove a amine from the molecule CCOC(=O)NC1=c2c(OC)cccc2=[NH+][C@H]1C(=O)OC.,CCOC(=O)NC1=c2c(OC)cccc2=[NH+][C@H]1C(=O)OC,amine
201571,Please remove a amide from the molecule CCc1ccccc1N1C[C@H](C(=O)NC[C@@H](C)Cn2cccn2)CC1=O.,CCc1ccccc1N1C[C@H](C(=O)NC[C@@H](C)Cn2cccn2)CC1=O,amide
157316,Modify the molecule [NH3+][C@H](c1cccc(F)c1)[C@@H]1CCOC2(CCC2)C1 by removing a halo.,[NH3+][C@H](c1cccc(F)c1)[C@@H]1CCOC2(CCC2)C1,halo
107757,Modify the molecule COc1cccc(S(=O)(=O)/N=C(\[O-])CCn2cc(C)cn2)c1 by removing a benzene_ring.,COc1cccc(S(=O)(=O)/N=C(\[O-])CCn2cc(C)cn2)c1,benzene_ring
114051,Please remove a benzene_ring from the molecule CC[C@H](CC1CCCC1)C(=O)Nc1cc(C(=O)N(C)C)ccc1C.,CC[C@H](CC1CCCC1)C(=O)Nc1cc(C(=O)N(C)C)ccc1C,benzene_ring
241547,Remove a benzene_ring from the molecule COc1ccc(OC)c(N2CCN(CC(=O)NCc3c(F)cccc3F)C2=O)c1.,COc1ccc(OC)c(N2CCN(CC(=O)NCc3c(F)cccc3F)C2=O)c1,benzene_ring
220034,Remove a amine from the molecule CCOc1ccccc1[C@H]1C2=C(CCCC2=O)Nc2onc(C)c21.,CCOc1ccccc1[C@H]1C2=C(CCCC2=O)Nc2onc(C)c21,amine
72735,Remove a halo from the molecule Cc1cc(F)cc(Nc2c(N)ccc(F)c2F)c1.,Cc1cc(F)cc(Nc2c(N)ccc(F)c2F)c1,halo
98798,Please remove a benzene_ring from the molecule C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[NH+](C)C1.,C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[NH+](C)C1,benzene_ring
142178,Please remove a hydroxyl from the molecule CC1(C)CC(NC(=O)NC[C@@H]2CCC[C@@H](O)C2)CC(C)(C)[NH2+]1.,CC1(C)CC(NC(=O)NC[C@@H]2CCC[C@@H](O)C2)CC(C)(C)[NH2+]1,hydroxyl
9647,Remove a halo from the molecule Cc1nn(C)c(Cl)c1[C@@H]1CCC[NH+]1CCCS(C)(=O)=O.,Cc1nn(C)c(Cl)c1[C@@H]1CCC[NH+]1CCCS(C)(=O)=O,halo
81314,Modify the molecule COc1cccc2cc(NC(=O)c3ccccc3)c(=O)oc12 by removing a benzene_ring.,COc1cccc2cc(NC(=O)c3ccccc3)c(=O)oc12,benzene_ring
53179,Remove a benzene_ring from the molecule O=C(O[C@H](c1ccccc1)c1nccs1)c1cccc2c1OCO2.,O=C(O[C@H](c1ccccc1)c1nccs1)c1cccc2c1OCO2,benzene_ring
168894,Remove a amide from the molecule CC(C)[C@H](NC(=O)c1cc(C(N)=O)cn1C)c1nnc2ccccn12.,CC(C)[C@H](NC(=O)c1cc(C(N)=O)cn1C)c1nnc2ccccn12,amide
99121,Modify the molecule CC(C)n1c(CC(=O)Nc2ccccc2F)n[nH]c1=S by removing a amide.,CC(C)n1c(CC(=O)Nc2ccccc2F)n[nH]c1=S,amide
218110,Please remove a benzene_ring from the molecule CC(C)C[NH2+]Cc1ncoc1-c1ccc(C(C)(C)C)cc1.,CC(C)C[NH2+]Cc1ncoc1-c1ccc(C(C)(C)C)cc1,benzene_ring
132672,Modify the molecule C[C@@H](C(=O)Nc1cccc(C(F)(F)F)c1)N1CC[NH+](C)CC1 by removing a amide.,C[C@@H](C(=O)Nc1cccc(C(F)(F)F)c1)N1CC[NH+](C)CC1,amide
178288,Please remove a benzene_ring from the molecule COC(=O)c1ccc(NC(=O)CN2C(=O)[C@@H]3[C@H](C2=O)[C@@H]2C=C[C@H]3[C@@H]3C[C@H]23)cc1.,COC(=O)c1ccc(NC(=O)CN2C(=O)[C@@H]3[C@H](C2=O)[C@@H]2C=C[C@H]3[C@@H]3C[C@H]23)cc1,benzene_ring
176026,Please remove a amine from the molecule O=C(NNS(=O)(=O)c1ccc2c(c1)CCC2)c1ccc2ccccc2n1.,O=C(NNS(=O)(=O)c1ccc2c(c1)CCC2)c1ccc2ccccc2n1,amine
77868,Please remove a halo from the molecule CC[C@@H](CSC)N(C)C(=O)N[C@H]1CCCc2ccc(F)cc21.,CC[C@@H](CSC)N(C)C(=O)N[C@H]1CCCc2ccc(F)cc21,halo
194305,Please remove a benzene_ring from the molecule CN(Cc1ccc(F)cc1F)C(=O)Cc1c(F)cccc1F.,CN(Cc1ccc(F)cc1F)C(=O)Cc1c(F)cccc1F,benzene_ring
207999,Please remove a amide from the molecule O=C([C@H]1Cc2ccccc2S1)N1C[C@H]2C[NH2+]C[C@@H]2C1.,O=C([C@H]1Cc2ccccc2S1)N1C[C@H]2C[NH2+]C[C@@H]2C1,amide
104866,Modify the molecule COc1ccc([C@]2(C)NC(=O)N(CC(=O)NCc3ccco3)C2=O)cc1 by removing a benzene_ring.,COc1ccc([C@]2(C)NC(=O)N(CC(=O)NCc3ccco3)C2=O)cc1,benzene_ring
231401,Remove a benzene_ring from the molecule Cc1ccccc1-c1noc(C2CCN(S(=O)(=O)c3cccs3)CC2)n1.,Cc1ccccc1-c1noc(C2CCN(S(=O)(=O)c3cccs3)CC2)n1,benzene_ring
8638,Remove a amide from the molecule CCc1cccc(C(=O)N[C@H]2CCC[C@@H]2C(=O)OC)c1O.,CCc1cccc(C(=O)N[C@H]2CCC[C@@H]2C(=O)OC)c1O,amide
63052,Remove a amine from the molecule Clc1cc2c(cc1NCc1nc3c(s1)CCC3)OCO2.,Clc1cc2c(cc1NCc1nc3c(s1)CCC3)OCO2,amine
2803,Please remove a amide from the molecule COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O.,COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O,amide
216816,Please remove a benzene_ring from the molecule O=C1NC2(CCCC2)C(=O)N1C[C@H](O)c1ccccc1C(F)(F)F.,O=C1NC2(CCCC2)C(=O)N1C[C@H](O)c1ccccc1C(F)(F)F,benzene_ring
115691,Remove a benzene_ring from the molecule Cc1cscc1C(=O)Cc1ccc(I)cc1.,Cc1cscc1C(=O)Cc1ccc(I)cc1,benzene_ring
22335,Please remove a amide from the molecule Cn1cc(CCC(=O)Nc2cc(-c3ccncc3)n[nH]2)cn1.,Cn1cc(CCC(=O)Nc2cc(-c3ccncc3)n[nH]2)cn1,amide
19280,Modify the molecule CC(C)N(CC(=O)N1C[C@H](C)O[C@H](C)C1)c1ccc(F)cc1 by removing a benzene_ring.,CC(C)N(CC(=O)N1C[C@H](C)O[C@H](C)C1)c1ccc(F)cc1,benzene_ring
160342,Please remove a benzene_ring from the molecule CNC(=O)c1cccc(NCc2cn(C)nc2-c2ccccc2)c1.,CNC(=O)c1cccc(NCc2cn(C)nc2-c2ccccc2)c1,benzene_ring
127504,Please remove a amide from the molecule CCOc1ncccc1C(=O)Nc1cc(F)c(N(C)C)c(F)c1.,CCOc1ncccc1C(=O)Nc1cc(F)c(N(C)C)c(F)c1,amide
232990,Remove a amide from the molecule CC[C@@](C)(NC(=O)c1cc(C)c(Br)s1)C(=O)[O-].,CC[C@@](C)(NC(=O)c1cc(C)c(Br)s1)C(=O)[O-],amide
123613,Remove a amine from the molecule COc1ccc(C(=O)Nc2ccc(Cl)cc2N)cc1O.,COc1ccc(C(=O)Nc2ccc(Cl)cc2N)cc1O,amine
208801,Modify the molecule CC(C)c1ccc(S(=O)(=O)N[C@@H](c2ccccc2F)c2nccn2C)cc1 by removing a amine.,CC(C)c1ccc(S(=O)(=O)N[C@@H](c2ccccc2F)c2nccn2C)cc1,amine
24096,Modify the molecule Cc1ccc(NC(=O)N(C)C)c(C(=O)Nc2cccc(F)c2C)c1 by removing a benzene_ring.,Cc1ccc(NC(=O)N(C)C)c(C(=O)Nc2cccc(F)c2C)c1,benzene_ring
137950,Modify the molecule O=C(O[C@@H](C(=O)NC1CC1)c1ccccc1)[C@H]1CC(=O)N(c2ccccc2F)C1 by removing a halo.,O=C(O[C@@H](C(=O)NC1CC1)c1ccccc1)[C@H]1CC(=O)N(c2ccccc2F)C1,halo
92831,Modify the molecule NC(=O)c1ccc(NC(=O)CN2C(=O)N[C@]3(CCCc4ccccc43)C2=O)cc1 by removing a benzene_ring.,NC(=O)c1ccc(NC(=O)CN2C(=O)N[C@]3(CCCc4ccccc43)C2=O)cc1,benzene_ring
34984,Please remove a amide from the molecule CC[C@H]1CCCC[C@H]1NC(=O)C(=O)Nc1cccc2cccnc12.,CC[C@H]1CCCC[C@H]1NC(=O)C(=O)Nc1cccc2cccnc12,amide
7586,Modify the molecule CCCS(=O)(=O)N1CCN(S(=O)(=O)Cc2ccccc2)CC1 by removing a benzene_ring.,CCCS(=O)(=O)N1CCN(S(=O)(=O)Cc2ccccc2)CC1,benzene_ring
52702,Please remove a amide from the molecule CNC(=O)c1ccc(CNC(=O)Nc2ccc(-c3csc(C)n3)cc2)cc1.,CNC(=O)c1ccc(CNC(=O)Nc2ccc(-c3csc(C)n3)cc2)cc1,amide
196840,Remove a benzene_ring from the molecule Cc1ccc(CNS(C)(=O)=O)c(OC(C)(C)C)c1.,Cc1ccc(CNS(C)(=O)=O)c(OC(C)(C)C)c1,benzene_ring
154802,Remove a benzene_ring from the molecule CSc1cccc(NC(=O)Cc2c(C)nc3cc(-c4ccccc4)nn3c2C)c1.,CSc1cccc(NC(=O)Cc2c(C)nc3cc(-c4ccccc4)nn3c2C)c1,benzene_ring
80594,Modify the molecule C[C@@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1C[NH+](C)C by removing a amide.,C[C@@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1C[NH+](C)C,amide
186201,Remove a amine from the molecule COC(=O)C[C@H](NS(=O)(=O)c1ccc(C)cc1)c1ccccc1.,COC(=O)C[C@H](NS(=O)(=O)c1ccc(C)cc1)c1ccccc1,amine
229585,Please remove a amide from the molecule C[C@H]([NH3+])C(=O)NCC1C(C)(C)C1(C)C.,C[C@H]([NH3+])C(=O)NCC1C(C)(C)C1(C)C,amide
230439,Modify the molecule COc1ccc(C(=O)N2CCN(c3nc4c(C)cccc4s3)CC2)c(OC)c1 by removing a benzene_ring.,COc1ccc(C(=O)N2CCN(c3nc4c(C)cccc4s3)CC2)c(OC)c1,benzene_ring
13551,Please remove a halo from the molecule CCN(Cc1cccc(C)n1)C[C@H](Br)C(F)(F)F.,CCN(Cc1cccc(C)n1)C[C@H](Br)C(F)(F)F,halo
80605,Please remove a benzene_ring from the molecule Cc1cc(OCc2ccccc2)nc(N2CCN(c3ccccc3)CC2)[nH+]1.,Cc1cc(OCc2ccccc2)nc(N2CCN(c3ccccc3)CC2)[nH+]1,benzene_ring
151885,Remove a amine from the molecule Cc1ccc(-c2nnc(SCC(=O)Nc3nc(C)cs3)n2N)cc1.,Cc1ccc(-c2nnc(SCC(=O)Nc3nc(C)cs3)n2N)cc1,amine
137107,Remove a amide from the molecule Cc1ccc([C@H](C)NC(=O)c2cc(C)c(C#CCN)s2)s1.,Cc1ccc([C@H](C)NC(=O)c2cc(C)c(C#CCN)s2)s1,amide
168700,Modify the molecule CC[C@@H](c1ncc(Cl)cc1Cl)[C@H](C)[NH3+] by removing a halo.,CC[C@@H](c1ncc(Cl)cc1Cl)[C@H](C)[NH3+],halo
19903,Modify the molecule CCOc1ccc([N-]S(=O)(=O)[C@H]2C(C)=NC(C)=C2C(=O)N2CCCCC2)cc1 by removing a amide.,CCOc1ccc([N-]S(=O)(=O)[C@H]2C(C)=NC(C)=C2C(=O)N2CCCCC2)cc1,amide
71540,Modify the molecule COCCN1C[C@H](C(=O)Nc2cccnc2-n2cccn2)CC1=O by removing a amide.,COCCN1C[C@H](C(=O)Nc2cccnc2-n2cccn2)CC1=O,amide
220352,Modify the molecule O=C(NCCc1cc(F)cc2c1OCOC2)NC[C@@H]1CCCO1 by removing a halo.,O=C(NCCc1cc(F)cc2c1OCOC2)NC[C@@H]1CCCO1,halo
106534,Please remove a amide from the molecule CN1CCCCC/C1=N\S(=O)(=O)c1cccc(NC(=O)C2(C)CCCC2)c1.,CN1CCCCC/C1=N\S(=O)(=O)c1cccc(NC(=O)C2(C)CCCC2)c1,amide
182228,Modify the molecule C[C@@H](C(=O)Nc1ccccc1-n1cnnn1)n1nnc(-c2ccccc2)n1 by removing a benzene_ring.,C[C@@H](C(=O)Nc1ccccc1-n1cnnn1)n1nnc(-c2ccccc2)n1,benzene_ring
72311,Please remove a benzene_ring from the molecule CCC(C)(CC)NC(=O)Nc1ccc(C(=O)NCC(C)C)cc1.,CCC(C)(CC)NC(=O)Nc1ccc(C(=O)NCC(C)C)cc1,benzene_ring
149447,Please remove a amide from the molecule O=C(Nc1cc(F)ccc1Cl)[C@@H]1CCCCN1C(=O)c1ccco1.,O=C(Nc1cc(F)ccc1Cl)[C@@H]1CCCCN1C(=O)c1ccco1,amide
27234,Remove a amide from the molecule CCCNC(=O)C1CC[NH+](CCC(=O)Nc2ccc(Cl)cc2)CC1.,CCCNC(=O)C1CC[NH+](CCC(=O)Nc2ccc(Cl)cc2)CC1,amide
206907,Remove a halo from the molecule C[C@H]1CCC[C@@H](NC(=O)COCC(F)(F)F)C1.,C[C@H]1CCC[C@@H](NC(=O)COCC(F)(F)F)C1,halo
98029,Please remove a benzene_ring from the molecule CC(C)Cn1ccnc(N[C@@H]2CCO[C@@H]2c2ccc(Cl)cc2)c1=O.,CC(C)Cn1ccnc(N[C@@H]2CCO[C@@H]2c2ccc(Cl)cc2)c1=O,benzene_ring
91605,Please remove a benzene_ring from the molecule O=C(Nc1cnn(-c2ccc(C(=O)N[C@@H]3CCC[NH+](Cc4ccccc4)C3)cc2)c1)c1cccnc1.,O=C(Nc1cnn(-c2ccc(C(=O)N[C@@H]3CCC[NH+](Cc4ccccc4)C3)cc2)c1)c1cccnc1,benzene_ring
47351,Please remove a halo from the molecule O=S1(=O)c2cccc3cccc(c23)N1C[C@@H](O)COc1ccc(Cl)cc1Cl.,O=S1(=O)c2cccc3cccc(c23)N1C[C@@H](O)COc1ccc(Cl)cc1Cl,halo
128315,Remove a nitro from the molecule O=C(c1ccc([N+](=O)[O-])o1)N1CCC(c2nc3ccccc3o2)CC1.,O=C(c1ccc([N+](=O)[O-])o1)N1CCC(c2nc3ccccc3o2)CC1,nitro
50970,Please remove a benzene_ring from the molecule CCCN(CCO)C(=O)Nc1cccc(C(=O)Nc2cccc(C#N)c2)c1.,CCCN(CCO)C(=O)Nc1cccc(C(=O)Nc2cccc(C#N)c2)c1,benzene_ring
130521,Modify the molecule COc1ccc(C(=O)C(/C=N\O)=N\Nc2ccc(F)cc2)cc1 by removing a halo.,COc1ccc(C(=O)C(/C=N\O)=N\Nc2ccc(F)cc2)cc1,halo
54928,Please remove a benzene_ring from the molecule CC1(C)C[C@]2(C[C@H](c3ccccc3)Oc3cc(O)ccc32)[NH+]=C([S-])N1.,CC1(C)C[C@]2(C[C@H](c3ccccc3)Oc3cc(O)ccc32)[NH+]=C([S-])N1,benzene_ring
237718,Remove a amide from the molecule COC(=O)c1ccc(F)c(NCc2cc(C(N)=O)cs2)c1.,COC(=O)c1ccc(F)c(NCc2cc(C(N)=O)cs2)c1,amide
53927,Remove a halo from the molecule O=C(Cn1nc(-c2ccc(F)cc2)oc1=O)OCc1nc2ccccc2s1.,O=C(Cn1nc(-c2ccc(F)cc2)oc1=O)OCc1nc2ccccc2s1,halo
207805,Remove a amide from the molecule Cc1[nH+]c([C@H]2CCCCN2C(=O)Cc2ccccn2)nc2c1CCCN2Cc1ccccc1.,Cc1[nH+]c([C@H]2CCCCN2C(=O)Cc2ccccn2)nc2c1CCCN2Cc1ccccc1,amide
159281,Remove a amide from the molecule C[C@@H]1OCC[C@H]1C(=O)N(CC(=O)N1CCCC1)C[C@@H]1CCCO1.,C[C@@H]1OCC[C@H]1C(=O)N(CC(=O)N1CCCC1)C[C@@H]1CCCO1,amide
180179,Modify the molecule O=C(CSc1ccc(F)cc1)NCc1n[nH]c(=O)c2ccccc12 by removing a halo.,O=C(CSc1ccc(F)cc1)NCc1n[nH]c(=O)c2ccccc12,halo
146804,Remove a nitro from the molecule CNc1cc(CN(C)C[C@@H]2CC[NH+](C)C2)ccc1[N+](=O)[O-].,CNc1cc(CN(C)C[C@@H]2CC[NH+](C)C2)ccc1[N+](=O)[O-],nitro
213064,Remove a benzene_ring from the molecule C=C(C)CN(CC)C(=O)CS(=O)(=O)c1ccc(F)c(F)c1.,C=C(C)CN(CC)C(=O)CS(=O)(=O)c1ccc(F)c(F)c1,benzene_ring
155185,Modify the molecule CC(C)C(=O)Nc1cccc(C(=O)Nc2ccccc2C#N)c1 by removing a benzene_ring.,CC(C)C(=O)Nc1cccc(C(=O)Nc2ccccc2C#N)c1,benzene_ring
101186,Modify the molecule N#Cc1ccc(-c2noc(-c3cccc(NC(=O)C4CC4)c3)n2)nc1 by removing a nitrile.,N#Cc1ccc(-c2noc(-c3cccc(NC(=O)C4CC4)c3)n2)nc1,nitrile
116057,Modify the molecule C[C@@H]([NH2+]CCN1C(=O)CCC1=O)c1cccc(-c2ccccc2)c1 by removing a benzene_ring.,C[C@@H]([NH2+]CCN1C(=O)CCC1=O)c1cccc(-c2ccccc2)c1,benzene_ring
205974,Please remove a amine from the molecule c1cc2c(cc1NC1=[N+]3CCCC[C@@H]3CS1)OCO2.,c1cc2c(cc1NC1=[N+]3CCCC[C@@H]3CS1)OCO2,amine
8229,Please remove a benzene_ring from the molecule Cc1nnc(S[C@@H](C)C(=O)N(C)c2ccccc2)s1.,Cc1nnc(S[C@@H](C)C(=O)N(C)c2ccccc2)s1,benzene_ring
86280,Please remove a halo from the molecule CC(=O)Nc1cc(NC(=O)N[C@@H]2CC=CCC2)ccc1Cl.,CC(=O)Nc1cc(NC(=O)N[C@@H]2CC=CCC2)ccc1Cl,halo
56170,Remove a amide from the molecule O=C(/C=C/c1ccc(Br)o1)NCCC1=CCCCC1.,O=C(/C=C/c1ccc(Br)o1)NCCC1=CCCCC1,amide
221493,Please remove a amide from the molecule COCc1ccc(C(=O)N[C@@H]2C[C@H]3C[C@@H]2[C@H]2CCC[C@@H]23)cc1.,COCc1ccc(C(=O)N[C@@H]2C[C@H]3C[C@@H]2[C@H]2CCC[C@@H]23)cc1,amide
30916,Remove a halo from the molecule C[C@H](NC(=O)c1nc(Cl)ccc1Cl)c1ccc(Cl)s1.,C[C@H](NC(=O)c1nc(Cl)ccc1Cl)c1ccc(Cl)s1,halo
245936,Please remove a benzene_ring from the molecule Cc1ccc(CC(=O)N2CC[C@@H]3[C@@H](CCC[NH+]3Cc3ccccc3)C2)cc1O.,Cc1ccc(CC(=O)N2CC[C@@H]3[C@@H](CCC[NH+]3Cc3ccccc3)C2)cc1O,benzene_ring
197966,Remove a amide from the molecule CCCCN(C(=O)[C@H](C)[NH+]1CCC[C@H](O)C1)[C@@H]1CCS(=O)(=O)C1.,CCCCN(C(=O)[C@H](C)[NH+]1CCC[C@H](O)C1)[C@@H]1CCS(=O)(=O)C1,amide
1848,Modify the molecule COc1ccc([C@@H]2c3nc[nH]c3CCN2C(=O)c2cc(C3CC3)nc3ccccc23)cc1 by removing a benzene_ring.,COc1ccc([C@@H]2c3nc[nH]c3CCN2C(=O)c2cc(C3CC3)nc3ccccc23)cc1,benzene_ring
16370,Please remove a benzene_ring from the molecule CCCS(=O)(=O)CC(=O)Nc1c(C)cccc1C(C)C.,CCCS(=O)(=O)CC(=O)Nc1c(C)cccc1C(C)C,benzene_ring
207588,Remove a benzene_ring from the molecule C[C@@H]1CN(c2ccc(CCl)cc2F)C[C@H]1C.,C[C@@H]1CN(c2ccc(CCl)cc2F)C[C@H]1C,benzene_ring
141555,Please remove a amine from the molecule Nc1cc(N)nc(SCc2cc(-c3cccs3)on2)n1.,Nc1cc(N)nc(SCc2cc(-c3cccs3)on2)n1,amine
104518,Please remove a hydroxyl from the molecule CC[NH+](Cc1ccc(Oc2ncccn2)cc1)[C@H]1CS(=O)(=O)C[C@@H]1O.,CC[NH+](Cc1ccc(Oc2ncccn2)cc1)[C@H]1CS(=O)(=O)C[C@@H]1O,hydroxyl
126475,Remove a amide from the molecule CCC(=O)Nc1nonc1-c1nc2ccccc2n1Cc1cc(OC)ccc1C.,CCC(=O)Nc1nonc1-c1nc2ccccc2n1Cc1cc(OC)ccc1C,amide
182561,Remove a amide from the molecule CC[NH+]1CCC[C@H](NC(=O)[C@@H]2CCC[NH2+][C@@H]2C)C1.,CC[NH+]1CCC[C@H](NC(=O)[C@@H]2CCC[NH2+][C@@H]2C)C1,amide
195974,Modify the molecule COc1ccccc1NC(=O)c1c([O-])c2sccc2n(Cc2ccccc2)c1=O by removing a benzene_ring.,COc1ccccc1NC(=O)c1c([O-])c2sccc2n(Cc2ccccc2)c1=O,benzene_ring
6766,Modify the molecule [NH3+]CCOCC(=O)Nc1ccc2c(c1)OCCO2 by removing a amide.,[NH3+]CCOCC(=O)Nc1ccc2c(c1)OCCO2,amide
73039,Please remove a amide from the molecule N#Cc1csc(C(=O)N2C[C@H]3CC=CC[C@@H]3C2)c1.,N#Cc1csc(C(=O)N2C[C@H]3CC=CC[C@@H]3C2)c1,amide
16747,Modify the molecule O=C(CCl)N1N=C(c2cccs2)C[C@@H]1c1ccccc1 by removing a halo.,O=C(CCl)N1N=C(c2cccs2)C[C@@H]1c1ccccc1,halo
47134,Modify the molecule O=C(NCc1ccnc(Oc2ccc(F)cc2)c1)N[C@@H]1CCCC[C@@H]1CO by removing a halo.,O=C(NCc1ccnc(Oc2ccc(F)cc2)c1)N[C@@H]1CCCC[C@@H]1CO,halo
184568,Please remove a benzene_ring from the molecule COc1ccc(/N=C2/CC(=O)C(=O)c3ccccc32)cc1.,COc1ccc(/N=C2/CC(=O)C(=O)c3ccccc32)cc1,benzene_ring
130104,Please remove a amine from the molecule CCc1nnc2sc(-c3ccc(CNC(=S)NC(=O)c4ccc(F)cc4)cc3)nn12.,CCc1nnc2sc(-c3ccc(CNC(=S)NC(=O)c4ccc(F)cc4)cc3)nn12,amine
238818,Modify the molecule CCC(CC)[C@H](O)[C@H]1CCO[C@]2(CCOC2)C1 by removing a hydroxyl.,CCC(CC)[C@H](O)[C@H]1CCO[C@]2(CCOC2)C1,hydroxyl
144915,Remove a amide from the molecule O=C(N[C@@H](C(=O)NCCN1CCOCC1)C12CC3CC(CC(C3)C1)C2)c1ccc(Cl)cc1.,O=C(N[C@@H](C(=O)NCCN1CCOCC1)C12CC3CC(CC(C3)C1)C2)c1ccc(Cl)cc1,amide
154888,Please remove a amine from the molecule O=C(NNc1nc(-c2ccncc2)no1)Nc1cnc(C2CC2)nc1.,O=C(NNc1nc(-c2ccncc2)no1)Nc1cnc(C2CC2)nc1,amine
102234,Remove a hydroxyl from the molecule O=C(COc1ccc(Br)cc1)N1CCC[C@@H](O)C1.,O=C(COc1ccc(Br)cc1)N1CCC[C@@H](O)C1,hydroxyl
200028,Remove a benzene_ring from the molecule COc1cccc(/C=N/NC(=O)C(=O)Nc2ccccc2Cl)c1OC.,COc1cccc(/C=N/NC(=O)C(=O)Nc2ccccc2Cl)c1OC,benzene_ring
64683,Remove a amide from the molecule O=C(Nc1cccc(CNC(=O)[C@@H]2COc3ccccc3O2)c1)C1CC1.,O=C(Nc1cccc(CNC(=O)[C@@H]2COc3ccccc3O2)c1)C1CC1,amide
75899,Please remove a amide from the molecule CCO[C@@H]1C[C@@H]([O-])C12CCN(C(=O)c1cnc3c(C)cccn3c1=O)CC2.,CCO[C@@H]1C[C@@H]([O-])C12CCN(C(=O)c1cnc3c(C)cccn3c1=O)CC2,amide
152411,Remove a nitrile from the molecule CN[C@]1(C#N)CCC[C@@H]1CC[NH+]1CC[C@@H]2CCCC[C@@H]2C1.,CN[C@]1(C#N)CCC[C@@H]1CC[NH+]1CC[C@@H]2CCCC[C@@H]2C1,nitrile
132417,Remove a halo from the molecule C[C@H]([NH2+][C@@H]1c2cccc(F)c2CC[C@@H]1C)c1nccs1.,C[C@H]([NH2+][C@@H]1c2cccc(F)c2CC[C@@H]1C)c1nccs1,halo
194995,Please remove a halo from the molecule C[C@@H](C(N)=O)[NH+]1CCN(C(=O)c2ccc(C(F)(F)F)cc2)CC1.,C[C@@H](C(N)=O)[NH+]1CCN(C(=O)c2ccc(C(F)(F)F)cc2)CC1,halo
70787,Please remove a hydroxyl from the molecule COc1ccc(Cl)cc1[C@H](O)[C@H]1CSCCS1.,COc1ccc(Cl)cc1[C@H](O)[C@H]1CSCCS1,hydroxyl
120334,Remove a amide from the molecule CCn1c(SCC(=O)N[C@@H]2CCCC[C@H]2C)nc2ncccc2c1=O.,CCn1c(SCC(=O)N[C@@H]2CCCC[C@H]2C)nc2ncccc2c1=O,amide
196649,Please remove a benzene_ring from the molecule NC(=O)c1ccc(N2CCO[C@@H](c3ccc(F)c(Cl)c3)C2)nn1.,NC(=O)c1ccc(N2CCO[C@@H](c3ccc(F)c(Cl)c3)C2)nn1,benzene_ring
118964,Modify the molecule CCOC(=O)Nc1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1 by removing a amine.,CCOC(=O)Nc1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1,amine
38820,Remove a amide from the molecule CNC(=O)c1ccc(N[C@H]2CCCC[C@H]2C)c([N+](=O)[O-])c1.,CNC(=O)c1ccc(N[C@H]2CCCC[C@H]2C)c([N+](=O)[O-])c1,amide
70715,Remove a benzene_ring from the molecule CN(CCN1CCOCC1)C(=O)CCc1ncc(-c2ccccc2)o1.,CN(CCN1CCOCC1)C(=O)CCc1ncc(-c2ccccc2)o1,benzene_ring
172041,Modify the molecule CC1(C)C[C@@](C#N)(NC2CCCC2)C(C)(C)O1 by removing a nitrile.,CC1(C)C[C@@](C#N)(NC2CCCC2)C(C)(C)O1,nitrile
88381,Modify the molecule COC(=O)C1(NC(=O)c2cc3cc(C)ccc3o2)CCSCC1 by removing a amide.,COC(=O)C1(NC(=O)c2cc3cc(C)ccc3o2)CCSCC1,amide
10606,Please remove a benzene_ring from the molecule Cc1cc(C)c(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cc1C.,Cc1cc(C)c(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cc1C,benzene_ring
212892,Modify the molecule O=C(N[C@@H](c1cccnc1)C(F)(F)F)c1cnn(-c2nccc(-c3ccco3)n2)c1C1CC1 by removing a amide.,O=C(N[C@@H](c1cccnc1)C(F)(F)F)c1cnn(-c2nccc(-c3ccco3)n2)c1C1CC1,amide
205220,Please remove a amide from the molecule CC1=C(C(=O)Nc2ccccc2C)C2(CCCCC2)[C@H](C(N)=O)C(=O)N1.,CC1=C(C(=O)Nc2ccccc2C)C2(CCCCC2)[C@H](C(N)=O)C(=O)N1,amide
32498,Please remove a hydroxyl from the molecule CCCCCC[C@@H](O)[C@H]1CCc2cccnc21.,CCCCCC[C@@H](O)[C@H]1CCc2cccnc21,hydroxyl
143677,Modify the molecule CN[C@]1(C#N)CCC[C@H]1CCOc1ccccc1 by removing a amine.,CN[C@]1(C#N)CCC[C@H]1CCOc1ccccc1,amine
224917,Modify the molecule Nc1nc(N2CC[C@@H](OCCCc3ccccc3)C2)ncc1[N+](=O)[O-] by removing a nitro.,Nc1nc(N2CC[C@@H](OCCCc3ccccc3)C2)ncc1[N+](=O)[O-],nitro
239462,Modify the molecule COc1ccc([C@H](NC(=O)c2cccc(OC)n2)c2nccn2C)cc1 by removing a benzene_ring.,COc1ccc([C@H](NC(=O)c2cccc(OC)n2)c2nccn2C)cc1,benzene_ring
46292,Modify the molecule O=C(Nc1ccc(OCCc2ccccc2)nc1)C(=O)N[C@@H]1CC=CCC1 by removing a amide.,O=C(Nc1ccc(OCCc2ccccc2)nc1)C(=O)N[C@@H]1CC=CCC1,amide
77301,Remove a amide from the molecule Cc1ccc2[nH+]c(N3CCC(C(=O)NCCC[NH+]4CCN(c5ccc(F)cc5)CC4)CC3)[nH]c2c1.,Cc1ccc2[nH+]c(N3CCC(C(=O)NCCC[NH+]4CCN(c5ccc(F)cc5)CC4)CC3)[nH]c2c1,amide
154188,Please remove a halo from the molecule CC(C)C(=O)NCCC[NH2+][C@@H]1CCc2c(F)cc(Br)cc21.,CC(C)C(=O)NCCC[NH2+][C@@H]1CCc2c(F)cc(Br)cc21,halo
166148,Remove a amide from the molecule Cc1ccc(NC(=O)C[C@@H](NC(N)=O)c2ccccc2)cc1C(F)(F)F.,Cc1ccc(NC(=O)C[C@@H](NC(N)=O)c2ccccc2)cc1C(F)(F)F,amide
232520,Please remove a amide from the molecule C[C@@H]1Cc2cc(C(=O)N3CCn4c(nnc4C4CC[NH+](C)CC4)C3)ccc2O1.,C[C@@H]1Cc2cc(C(=O)N3CCn4c(nnc4C4CC[NH+](C)CC4)C3)ccc2O1,amide
194565,Please remove a amide from the molecule COc1ccc(CN(C)C(=O)CSCc2ccc(F)cc2)cc1.,COc1ccc(CN(C)C(=O)CSCc2ccc(F)cc2)cc1,amide
243451,Modify the molecule O=C(/C=C/c1ccco1)N(CCN1CCOCC1)c1ccccc1 by removing a benzene_ring.,O=C(/C=C/c1ccco1)N(CCN1CCOCC1)c1ccccc1,benzene_ring
83226,Modify the molecule CC[C@@H]1COCCN1C(=O)[C@@H]1CC(=O)N(c2cc(OC)c(OC)c(OC)c2)C1 by removing a benzene_ring.,CC[C@@H]1COCCN1C(=O)[C@@H]1CC(=O)N(c2cc(OC)c(OC)c(OC)c2)C1,benzene_ring
233934,Please remove a amide from the molecule Cc1ccc(NC(=O)CSc2nc3ccccc3nc2N2CCOCC2)cc1.,Cc1ccc(NC(=O)CSc2nc3ccccc3nc2N2CCOCC2)cc1,amide
174911,Modify the molecule C[C@H]1CCCC[C@H]1NC(=O)C[NH+]1CCc2nc(N3CCCC3)[nH]c(=O)c2C1 by removing a amide.,C[C@H]1CCCC[C@H]1NC(=O)C[NH+]1CCc2nc(N3CCCC3)[nH]c(=O)c2C1,amide
801,Modify the molecule CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1 by removing a amide.,CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1,amide
122701,Remove a amide from the molecule O=C(Cc1cccs1)N1CCc2nocc2C1.,O=C(Cc1cccs1)N1CCc2nocc2C1,amide
204458,Remove a benzene_ring from the molecule COc1ccc(CC(=O)Nc2ccc3c(c2)CN(CCc2ccc(F)cc2)C(=O)[C@H](C)O3)cc1.,COc1ccc(CC(=O)Nc2ccc3c(c2)CN(CCc2ccc(F)cc2)C(=O)[C@H](C)O3)cc1,benzene_ring
220493,Modify the molecule COc1ccc([C@@H]2CC(=O)Nc3c2c([O-])nc2nc4ccccc4n32)cc1OC by removing a benzene_ring.,COc1ccc([C@@H]2CC(=O)Nc3c2c([O-])nc2nc4ccccc4n32)cc1OC,benzene_ring
23002,Remove a amide from the molecule CN(Cc1ccc(N(C)C)cc1)C(=O)c1cccc(-n2cnnn2)c1.,CN(Cc1ccc(N(C)C)cc1)C(=O)c1cccc(-n2cnnn2)c1,amide
191351,Modify the molecule COc1ccc(CCNC(=O)c2sc(-c3c(F)cccc3OC)nc2C)cc1 by removing a benzene_ring.,COc1ccc(CCNC(=O)c2sc(-c3c(F)cccc3OC)nc2C)cc1,benzene_ring
175391,Remove a benzene_ring from the molecule Cc1nnc(-c2cc(S(=O)(=O)N3CCN(c4cc(Cl)ccc4C)CC3)c[nH]2)o1.,Cc1nnc(-c2cc(S(=O)(=O)N3CCN(c4cc(Cl)ccc4C)CC3)c[nH]2)o1,benzene_ring
170463,Please remove a amide from the molecule C[C@@]1(C(=O)N[C@H]2CCN(c3ccccc3)C2=O)Cc2ccccc2C(=O)O1.,C[C@@]1(C(=O)N[C@H]2CCN(c3ccccc3)C2=O)Cc2ccccc2C(=O)O1,amide
70807,Please remove a benzene_ring from the molecule COc1ccc(/C=C/c2ccnc(NS(=O)(=O)c3ccc(N)cc3)n2)cc1.,COc1ccc(/C=C/c2ccnc(NS(=O)(=O)c3ccc(N)cc3)n2)cc1,benzene_ring
66073,Please remove a amide from the molecule COCCN(Cc1ccoc1)C(=O)c1c(F)cccc1F.,COCCN(Cc1ccoc1)C(=O)c1c(F)cccc1F,amide
224338,Modify the molecule Cc1cccc([C@H]2[C@@H](C(=O)[O-])CC(=O)N2C)c1 by removing a benzene_ring.,Cc1cccc([C@H]2[C@@H](C(=O)[O-])CC(=O)N2C)c1,benzene_ring
106986,Remove a amine from the molecule C[C@H](NC(=O)CNc1cccc(NC(=O)c2ccco2)c1)c1ccccc1.,C[C@H](NC(=O)CNc1cccc(NC(=O)c2ccco2)c1)c1ccccc1,amine
45788,Remove a amide from the molecule CC(=O)c1cccc(NC(=O)N2CCC(C(=O)N(C)C(C)C)CC2)c1.,CC(=O)c1cccc(NC(=O)N2CCC(C(=O)N(C)C(C)C)CC2)c1,amide
38278,Modify the molecule CCOC(=O)c1cccc(NC[C@@](C)(O)c2cccs2)n1 by removing a amine.,CCOC(=O)c1cccc(NC[C@@](C)(O)c2cccs2)n1,amine
45720,Please remove a benzene_ring from the molecule CSc1ccccc1[C@H](Cl)[C@@H](C)c1ccncc1.,CSc1ccccc1[C@H](Cl)[C@@H](C)c1ccncc1,benzene_ring
136717,Modify the molecule CC(C)(C)OC(=O)N1CCC[C@@H]1C[S@@](=O)c1nc2cc([N+](=O)[O-])ccc2s1 by removing a nitro.,CC(C)(C)OC(=O)N1CCC[C@@H]1C[S@@](=O)c1nc2cc([N+](=O)[O-])ccc2s1,nitro
128495,Please remove a amide from the molecule O=C(N[C@H]1CCCc2ccccc21)c1ccc2c(c1)[nH]c(=O)n2C1CCCC1.,O=C(N[C@H]1CCCc2ccccc21)c1ccc2c(c1)[nH]c(=O)n2C1CCCC1,amide
143236,Modify the molecule CCc1nsc(NCCS(=O)(=O)CC)n1 by removing a amine.,CCc1nsc(NCCS(=O)(=O)CC)n1,amine
85147,Modify the molecule Cn1c(S[C@H]2CCCCNC2=O)nc2sc3c(c2c1=O)CCC3 by removing a amide.,Cn1c(S[C@H]2CCCCNC2=O)nc2sc3c(c2c1=O)CCC3,amide
246965,Modify the molecule CCc1c(C(=O)N2C[C@@H](c3ccccc3C)C[C@@H]2C)[nH]c(C)c1C(C)=O by removing a benzene_ring.,CCc1c(C(=O)N2C[C@@H](c3ccccc3C)C[C@@H]2C)[nH]c(C)c1C(C)=O,benzene_ring
203006,Remove a nitro from the molecule CC(C)c1cc(C(=O)NNC(=O)c2cccc([N+](=O)[O-])c2)nn1C.,CC(C)c1cc(C(=O)NNC(=O)c2cccc([N+](=O)[O-])c2)nn1C,nitro
227582,Please remove a amide from the molecule CCCn1cc(C(=O)NCc2cc(CC(C)C)on2)c(C)n1.,CCCn1cc(C(=O)NCc2cc(CC(C)C)on2)c(C)n1,amide
57732,Please remove a benzene_ring from the molecule O=C(/C=C/c1ccccc1[N+](=O)[O-])OCC(=O)c1ccc2c(c1)OCO2.,O=C(/C=C/c1ccccc1[N+](=O)[O-])OCC(=O)c1ccc2c(c1)OCO2,benzene_ring
76202,Please remove a benzene_ring from the molecule Cc1ccc(N2C(=O)N(Cc3ccccc3Cl)[C@H]3CS(=O)(=O)C[C@@H]32)cc1Cl.,Cc1ccc(N2C(=O)N(Cc3ccccc3Cl)[C@H]3CS(=O)(=O)C[C@@H]32)cc1Cl,benzene_ring
68858,Please remove a halo from the molecule O=C(Nc1cnn(CC(F)F)c1)N1CCC[C@@H](C[NH+]2CCCCCC2)C1.,O=C(Nc1cnn(CC(F)F)c1)N1CCC[C@@H](C[NH+]2CCCCCC2)C1,halo
12325,Please remove a halo from the molecule Cc1ccccc1OCCN(C)S(=O)(=O)c1ncn(C)c1Cl.,Cc1ccccc1OCCN(C)S(=O)(=O)c1ncn(C)c1Cl,halo
220024,Modify the molecule COc1c(C)cc(CN2C[C@@H](C)OC[C@@H]2C)cc1C by removing a benzene_ring.,COc1c(C)cc(CN2C[C@@H](C)OC[C@@H]2C)cc1C,benzene_ring
7538,Modify the molecule Cc1ccc(NC(=O)N2CCC[C@H](c3nnc(C(=O)Nc4ccc(F)cc4)s3)C2)c(C)c1 by removing a amide.,Cc1ccc(NC(=O)N2CCC[C@H](c3nnc(C(=O)Nc4ccc(F)cc4)s3)C2)c(C)c1,amide
208329,Please remove a hydroxyl from the molecule COc1cc2c(cc1C[NH+]1[C@H]3CC[C@@H]1CC(O)(Cn1nc(C4CC4)ccc1=O)C3)CCC2.,COc1cc2c(cc1C[NH+]1[C@H]3CC[C@@H]1CC(O)(Cn1nc(C4CC4)ccc1=O)C3)CCC2,hydroxyl
106199,Please remove a halo from the molecule Cc1onc(-c2ccccc2Cl)c1C(=O)NCCC1[NH+]=c2ccccc2=[NH+]1.,Cc1onc(-c2ccccc2Cl)c1C(=O)NCCC1[NH+]=c2ccccc2=[NH+]1,halo
129766,Modify the molecule CN[C@]1(C#N)CC[C@@H](N2CCO[C@H](C)C2)C1 by removing a nitrile.,CN[C@]1(C#N)CC[C@@H](N2CCO[C@H](C)C2)C1,nitrile
93944,Please remove a amine from the molecule CCN(CCNS(C)(=O)=O)c1cccc(C)c1.,CCN(CCNS(C)(=O)=O)c1cccc(C)c1,amine
136921,Please remove a amide from the molecule COC(=O)[C@@H](NC(=O)[C@@H](C)Cc1ccccc1F)c1ccc(F)c(F)c1.,COC(=O)[C@@H](NC(=O)[C@@H](C)Cc1ccccc1F)c1ccc(F)c(F)c1,amide
209290,Modify the molecule COCC[NH+](C1C[C@@H](C)C[C@H](C)C1)[C@@H](C)C(N)=O by removing a amide.,COCC[NH+](C1C[C@@H](C)C[C@H](C)C1)[C@@H](C)C(N)=O,amide
80000,Modify the molecule CC(C)c1cc(C(F)(F)F)c2c([C@@H]3CCCN(C(=O)CN4CCCC4=O)C3)noc2n1 by removing a halo.,CC(C)c1cc(C(F)(F)F)c2c([C@@H]3CCCN(C(=O)CN4CCCC4=O)C3)noc2n1,halo
239399,Modify the molecule Cc1ncc([C@@H](C)[NH2+][C@H](C)c2ccc3c(c2)CC(=O)N3)s1 by removing a amide.,Cc1ncc([C@@H](C)[NH2+][C@H](C)c2ccc3c(c2)CC(=O)N3)s1,amide
60379,Please remove a amide from the molecule C[C@H](c1ccncc1)N(C)C(=O)[C@H]1C=C[C@@H]([NH3+])C1.,C[C@H](c1ccncc1)N(C)C(=O)[C@H]1C=C[C@@H]([NH3+])C1,amide
206573,Please remove a benzene_ring from the molecule CCOC(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@@H](c1cc(OC)c(OC)c(OC)c1)N2.,CCOC(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@@H](c1cc(OC)c(OC)c(OC)c1)N2,benzene_ring
146826,Modify the molecule Fc1cccc(F)c1N[C@@H]1CCCC[C@H]1[C@@H]1CCC[NH2+]1 by removing a halo.,Fc1cccc(F)c1N[C@@H]1CCCC[C@H]1[C@@H]1CCC[NH2+]1,halo
6552,Modify the molecule C/C=C(/C)C(=O)Nc1cc(Cl)ccc1N1CC[NH+](C)CC1 by removing a halo.,C/C=C(/C)C(=O)Nc1cc(Cl)ccc1N1CC[NH+](C)CC1,halo
84828,Please remove a halo from the molecule COc1cc(Br)cc(/C=N/c2ccc(F)cc2)c1O.,COc1cc(Br)cc(/C=N/c2ccc(F)cc2)c1O,halo
86565,Modify the molecule Cc1cccc(N2CCN(c3nc4ccccc4c(=O)[nH]3)CC2)c1 by removing a benzene_ring.,Cc1cccc(N2CCN(c3nc4ccccc4c(=O)[nH]3)CC2)c1,benzene_ring
202137,Remove a nitrile from the molecule CC(C)Cc1[nH]c(=O)c(C#N)c2c1COC(C)(C)C2.,CC(C)Cc1[nH]c(=O)c(C#N)c2c1COC(C)(C)C2,nitrile
42728,Remove a nitrile from the molecule CC[C@@H]1CCC[C@](C#N)(Cc2nccs2)C1.,CC[C@@H]1CCC[C@](C#N)(Cc2nccs2)C1,nitrile
220623,Modify the molecule CC(C)(C)OC(=O)/C=C(\N)c1ccccc1 by removing a benzene_ring.,CC(C)(C)OC(=O)/C=C(\N)c1ccccc1,benzene_ring
248662,Please remove a amine from the molecule CCc1c(N)nnn1CC[NH+]1CCCCC1.,CCc1c(N)nnn1CC[NH+]1CCCCC1,amine
12526,Remove a hydroxyl from the molecule C[N+]1(C[C@H](O)COC(=O)C23CC4CC(CC(C4)C2)C3)CCOCC1.,C[N+]1(C[C@H](O)COC(=O)C23CC4CC(CC(C4)C2)C3)CCOCC1,hydroxyl
127284,Remove a amide from the molecule CCCCCC[C@]1(C)NC(=O)N(Cc2csc(C)n2)C1=O.,CCCCCC[C@]1(C)NC(=O)N(Cc2csc(C)n2)C1=O,amide
180555,Please remove a benzene_ring from the molecule Cc1c(C(=O)NC(c2ccccc2)c2ccccc2)nnn1-c1ccccc1.,Cc1c(C(=O)NC(c2ccccc2)c2ccccc2)nnn1-c1ccccc1,benzene_ring
67109,Please remove a amide from the molecule CC(C)Cc1nnc(NC(=O)[C@H]2C[C@H]2c2cc(Cl)cc(Cl)c2)s1.,CC(C)Cc1nnc(NC(=O)[C@H]2C[C@H]2c2cc(Cl)cc(Cl)c2)s1,amide
51846,Please remove a benzene_ring from the molecule COCCCn1c(C(=O)Nc2ccc(C)cc2)cc2c(=O)n3ccccc3nc21.,COCCCn1c(C(=O)Nc2ccc(C)cc2)cc2c(=O)n3ccccc3nc21,benzene_ring
17810,Please remove a benzene_ring from the molecule Cc1cccc(N2CC[NH+]([C@@H](CC(C)C)c3nnnn3C(C)(C)C)CC2)c1C.,Cc1cccc(N2CC[NH+]([C@@H](CC(C)C)c3nnnn3C(C)(C)C)CC2)c1C,benzene_ring
194450,Modify the molecule O=C(CCOCc1ccccc1)NC[C@@H]1CN2CCCC[C@@H]2CO1 by removing a benzene_ring.,O=C(CCOCc1ccccc1)NC[C@@H]1CN2CCCC[C@@H]2CO1,benzene_ring
152787,Remove a benzene_ring from the molecule O=[N+]([O-])c1ccc(S(=O)(=O)Nc2nc(-c3ccco3)c(-c3ccco3)s2)cc1.,O=[N+]([O-])c1ccc(S(=O)(=O)Nc2nc(-c3ccco3)c(-c3ccco3)s2)cc1,benzene_ring
26972,Please remove a amide from the molecule COc1cccc(-c2cc(C(=O)N3CCN(C(=O)[C@@H]4C[C@@H]4c4ccccc4)CC3)[nH]n2)c1.,COc1cccc(-c2cc(C(=O)N3CCN(C(=O)[C@@H]4C[C@@H]4c4ccccc4)CC3)[nH]n2)c1,amide
77974,Remove a amide from the molecule C=CCn1c(SCC(=O)NC(=O)NCC(C)C)nc2ccccc21.,C=CCn1c(SCC(=O)NC(=O)NCC(C)C)nc2ccccc21,amide
194061,Modify the molecule Cc1ccc2c(c1)c1nnc(SCC(=O)N(C)C3CCCCC3)nc1n2C by removing a amide.,Cc1ccc2c(c1)c1nnc(SCC(=O)N(C)C3CCCCC3)nc1n2C,amide
63900,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)N2CCC[C@@H](c3nnc(C)s3)C2)cc1.,Cc1ccc(C(=O)N2CCC[C@@H](c3nnc(C)s3)C2)cc1,benzene_ring
35817,Remove a amine from the molecule CC(C)[C@H](Sc1nnc(-c2cccs2)n1N)C(=O)NC1CCCCC1.,CC(C)[C@H](Sc1nnc(-c2cccs2)n1N)C(=O)NC1CCCCC1,amine
104937,Remove a amine from the molecule Cc1ccc(CSc2cc(Cl)ccc2N)o1.,Cc1ccc(CSc2cc(Cl)ccc2N)o1,amine
85492,Modify the molecule Cc1nn(-c2ccccc2)c2nc(-c3cccs3)n3c4ccccc4nc3c2c1=O by removing a benzene_ring.,Cc1nn(-c2ccccc2)c2nc(-c3cccs3)n3c4ccccc4nc3c2c1=O,benzene_ring
234442,Please remove a amine from the molecule COC(=O)[C@@H](N)CSc1ccncc1.,COC(=O)[C@@H](N)CSc1ccncc1,amine
1022,Please remove a amide from the molecule C[C@H]1CC(=O)N(CC(=O)Nc2cccc3ccccc23)c2ccccc2S1.,C[C@H]1CC(=O)N(CC(=O)Nc2cccc3ccccc23)c2ccccc2S1,amide
40421,Please remove a hydroxyl from the molecule C[C@@H](O)CC(C)(C)CNC(=O)N1CCC[C@@H](O)C1.,C[C@@H](O)CC(C)(C)CNC(=O)N1CCC[C@@H](O)C1,hydroxyl
208146,Remove a benzene_ring from the molecule CN(C(=O)Cn1c(CCNC(=O)c2cccnc2)nc2ccccc21)c1ccccc1.,CN(C(=O)Cn1c(CCNC(=O)c2cccnc2)nc2ccccc21)c1ccccc1,benzene_ring
92757,Remove a halo from the molecule C=CCNC(=O)CCCn1nc([N+](=O)[O-])c(Br)c1C.,C=CCNC(=O)CCCn1nc([N+](=O)[O-])c(Br)c1C,halo
169594,Please remove a benzene_ring from the molecule COc1ccc(CN(C)Cc2c(C)n(C)n(-c3ccccc3)c2=O)cc1C.,COc1ccc(CN(C)Cc2c(C)n(C)n(-c3ccccc3)c2=O)cc1C,benzene_ring
138384,Modify the molecule CC(C)(O)C[C@]1(C(=O)[O-])CCc2ccccc2C1 by removing a hydroxyl.,CC(C)(O)C[C@]1(C(=O)[O-])CCc2ccccc2C1,hydroxyl
202592,Modify the molecule CCCN[C@@H]1[C@H]([NH+](CC(C)C)C(C)C)CCC1(C)C by removing a amine.,CCCN[C@@H]1[C@H]([NH+](CC(C)C)C(C)C)CCC1(C)C,amine
27197,Modify the molecule CC(=O)[C@@H]1CC[C@@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@@]4(C)[C@@H]3CC[C@]12C by removing a hydroxyl.,CC(=O)[C@@H]1CC[C@@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@@]4(C)[C@@H]3CC[C@]12C,hydroxyl
200183,Remove a benzene_ring from the molecule COc1ccc(OCC[NH2+][C@H]2CCC[C@H](C)[C@@H]2C)cc1.,COc1ccc(OCC[NH2+][C@H]2CCC[C@H](C)[C@@H]2C)cc1,benzene_ring
238169,Please remove a halo from the molecule CN(C[C@H](O)CN1CCOCC1)c1cc[nH+]cc1Cl.,CN(C[C@H](O)CN1CCOCC1)c1cc[nH+]cc1Cl,halo
24880,Modify the molecule Cc1ccc(-c2csc3ncn(CC(=O)Nc4ccc(F)cc4F)c(=O)c23)s1 by removing a benzene_ring.,Cc1ccc(-c2csc3ncn(CC(=O)Nc4ccc(F)cc4F)c(=O)c23)s1,benzene_ring
130283,Please remove a halo from the molecule C=C(C)C[NH2+]C[C@@]1(O)CCCN(Cc2ccc(F)c(F)c2)C1=O.,C=C(C)C[NH2+]C[C@@]1(O)CCCN(Cc2ccc(F)c(F)c2)C1=O,halo
140001,Please remove a halo from the molecule O=C(Nc1ccccc1Cl)NC12CC3CC(CC(C3)C1)C2.,O=C(Nc1ccccc1Cl)NC12CC3CC(CC(C3)C1)C2,halo
90657,Modify the molecule C[C@H](CCc1ccco1)NC(=O)c1ccc(Cl)c(S(C)(=O)=O)c1 by removing a amide.,C[C@H](CCc1ccco1)NC(=O)c1ccc(Cl)c(S(C)(=O)=O)c1,amide
63681,Please remove a benzene_ring from the molecule Cc1nc(C)n(Cc2cccc(NC(=O)[C@H](NC(N)=O)C(C)C)c2)n1.,Cc1nc(C)n(Cc2cccc(NC(=O)[C@H](NC(N)=O)C(C)C)c2)n1,benzene_ring
174358,Modify the molecule Cc1ccc(S(=O)(=O)N2CCOC[C@H]2c2c(C)n[nH]c2C)c(Br)c1 by removing a halo.,Cc1ccc(S(=O)(=O)N2CCOC[C@H]2c2c(C)n[nH]c2C)c(Br)c1,halo
196093,Please remove a halo from the molecule CCOC(=O)[C@@H](C)NCc1cc(Cl)cs1.,CCOC(=O)[C@@H](C)NCc1cc(Cl)cs1,halo
231018,Modify the molecule Cc1ccc(/C=N/C(C)C)cc1 by removing a benzene_ring.,Cc1ccc(/C=N/C(C)C)cc1,benzene_ring
219635,Modify the molecule CCC[C@H](C(N)=[NH2+])N1CCN(C(=O)N(CC)CC)CC1 by removing a amine.,CCC[C@H](C(N)=[NH2+])N1CCN(C(=O)N(CC)CC)CC1,amine
127514,Remove a amine from the molecule CCc1cnc(CCNc2ccccc2S(=O)(=O)C(F)F)s1.,CCc1cnc(CCNc2ccccc2S(=O)(=O)C(F)F)s1,amine
90111,Please remove a benzene_ring from the molecule Cc1nc(COc2ccccc2C(=O)N[C@H]2CCOc3ccccc32)no1.,Cc1nc(COc2ccccc2C(=O)N[C@H]2CCOc3ccccc32)no1,benzene_ring
196133,Modify the molecule CNC(=O)c1ccccc1NC(=O)c1ccc(Cl)cc1 by removing a benzene_ring.,CNC(=O)c1ccccc1NC(=O)c1ccc(Cl)cc1,benzene_ring
159529,Modify the molecule CCCN1C(=O)C(C)(C)COc2cc(NC(=O)Cc3ccc(OC)cc3)ccc21 by removing a amide.,CCCN1C(=O)C(C)(C)COc2cc(NC(=O)Cc3ccc(OC)cc3)ccc21,amide
32968,Remove a amide from the molecule CC(C)c1ocnc1CS[C@H](C)C(=O)NCc1ccc(F)cc1.,CC(C)c1ocnc1CS[C@H](C)C(=O)NCc1ccc(F)cc1,amide
15638,Remove a amide from the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1,amide
184890,Please remove a benzene_ring from the molecule O=C(Nc1cccc(-c2nnc3n2CCC3)c1)N[C@@H]1C[C@H]2CCCc3cccc1c32.,O=C(Nc1cccc(-c2nnc3n2CCC3)c1)N[C@@H]1C[C@H]2CCCc3cccc1c32,benzene_ring
121893,Please remove a amide from the molecule CC[C@@H]1C(=O)NCC[NH+]1Cc1nc(-c2ccccc2OC)oc1C.,CC[C@@H]1C(=O)NCC[NH+]1Cc1nc(-c2ccccc2OC)oc1C,amide
127891,Remove a amide from the molecule Cc1nc(-c2ccccc2Br)cc([C@H]2C[NH+]3CC[C@@H]2C[C@@H]3CNC(=O)c2ccco2)n1.,Cc1nc(-c2ccccc2Br)cc([C@H]2C[NH+]3CC[C@@H]2C[C@@H]3CNC(=O)c2ccco2)n1,amide
48183,Remove a nitrile from the molecule COc1ccc(-c2nc(COC(=O)c3cc(C#N)cn3C)no2)cc1.,COc1ccc(-c2nc(COC(=O)c3cc(C#N)cn3C)no2)cc1,nitrile
169419,Please remove a amide from the molecule CC(=O)Nc1ccc(C)c(NC(=O)N[C@H]2C[C@H]2C)c1.,CC(=O)Nc1ccc(C)c(NC(=O)N[C@H]2C[C@H]2C)c1,amide
184952,Please remove a amide from the molecule O=C(/C=C/c1nc2ccccc2o1)N1CCC[C@@H]1c1nnc2ccccn12.,O=C(/C=C/c1nc2ccccc2o1)N1CCC[C@@H]1c1nnc2ccccn12,amide
126094,Remove a amide from the molecule O=C(c1csc2c1CCCC2)N1CCC[C@@H](N2CCN(c3ccccc3)CC2)C1.,O=C(c1csc2c1CCCC2)N1CCC[C@@H](N2CCN(c3ccccc3)CC2)C1,amide
110357,Please remove a halo from the molecule CC1=C(C(=O)N(C)C)[C@@H](c2cc(F)ccc2F)NC(=S)N1.,CC1=C(C(=O)N(C)C)[C@@H](c2cc(F)ccc2F)NC(=S)N1,halo
186575,Remove a halo from the molecule COC(=O)/C(C)=C/CSc1cc(F)ccc1N.,COC(=O)/C(C)=C/CSc1cc(F)ccc1N,halo
27102,Please remove a benzene_ring from the molecule COc1ccc(CC(=O)NNC(=O)COc2ccc3ccccc3c2)cc1.,COc1ccc(CC(=O)NNC(=O)COc2ccc3ccccc3c2)cc1,benzene_ring
120304,Please remove a benzene_ring from the molecule C=CCn1nc(SC[C@@H](O)CO)nc1-c1ccc(Br)cc1.,C=CCn1nc(SC[C@@H](O)CO)nc1-c1ccc(Br)cc1,benzene_ring
19325,Please remove a benzene_ring from the molecule CCS(=O)(=O)c1ccc(CC(=O)Nc2nnc(-c3cccc(F)c3)o2)cc1.,CCS(=O)(=O)c1ccc(CC(=O)Nc2nnc(-c3cccc(F)c3)o2)cc1,benzene_ring
210893,Modify the molecule C=CCOc1ccc(OC(=O)c2ncccc2C(F)(F)F)cc1 by removing a benzene_ring.,C=CCOc1ccc(OC(=O)c2ncccc2C(F)(F)F)cc1,benzene_ring
218758,Modify the molecule Cl[C@@H](CNc1ccc2nnnn2n1)c1ccccc1 by removing a benzene_ring.,Cl[C@@H](CNc1ccc2nnnn2n1)c1ccccc1,benzene_ring
54429,Modify the molecule Cc1onc(-c2ccccc2)c1C(=O)N(C)CC(=O)N(C)C by removing a benzene_ring.,Cc1onc(-c2ccccc2)c1C(=O)N(C)CC(=O)N(C)C,benzene_ring
195696,Modify the molecule CC(=O)OC1=C(C(C)=O)N(C(C)=O)S(=O)(=O)c2ccccc21 by removing a amide.,CC(=O)OC1=C(C(C)=O)N(C(C)=O)S(=O)(=O)c2ccccc21,amide
88352,Remove a nitro from the molecule Cc1noc(/C=C\c2ccc3c(c2)n(C)c(=O)n3C)c1[N+](=O)[O-].,Cc1noc(/C=C\c2ccc3c(c2)n(C)c(=O)n3C)c1[N+](=O)[O-],nitro
213468,Remove a amide from the molecule CCS[C@H]1CCCCN(C(=O)[C@H](C)Sc2ccccn2)C1.,CCS[C@H]1CCCCN(C(=O)[C@H](C)Sc2ccccn2)C1,amide
221465,Please remove a amide from the molecule CC(C)(C)c1noc(CSCCCN2C(=O)CNC2=O)n1.,CC(C)(C)c1noc(CSCCCN2C(=O)CNC2=O)n1,amide
100645,Modify the molecule CN(Cc1ccccc1)S(=O)(=O)c1ccc(C(=O)Nc2nc3c(F)cc(F)cc3s2)cc1 by removing a amide.,CN(Cc1ccccc1)S(=O)(=O)c1ccc(C(=O)Nc2nc3c(F)cc(F)cc3s2)cc1,amide
5965,Please remove a nitro from the molecule CC[C@H]1CCCC[C@H]1[NH2+]Cc1ccc([N+](=O)[O-])cc1.,CC[C@H]1CCCC[C@H]1[NH2+]Cc1ccc([N+](=O)[O-])cc1,nitro
13120,Remove a benzene_ring from the molecule CC[NH2+][C@H]1[C@H]([S@@](=O)c2cccc(OC)c2)CCCC1(C)C.,CC[NH2+][C@H]1[C@H]([S@@](=O)c2cccc(OC)c2)CCCC1(C)C,benzene_ring
142592,Modify the molecule COC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)c1ccc(-c2ccccc2)cc1 by removing a amide.,COC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)c1ccc(-c2ccccc2)cc1,amide
198939,Modify the molecule COc1ccc(-c2onc3ccc(C(=O)/C=C/N(C)C)cc23)cc1 by removing a benzene_ring.,COc1ccc(-c2onc3ccc(C(=O)/C=C/N(C)C)cc23)cc1,benzene_ring
191966,Modify the molecule COc1ccccc1CC1CCN(C(=O)c2c(C)nn(C)c2C)CC1 by removing a benzene_ring.,COc1ccccc1CC1CCN(C(=O)c2c(C)nn(C)c2C)CC1,benzene_ring
32089,Modify the molecule CC(C)N(CCCO)c1nc(Cl)ncc1F by removing a hydroxyl.,CC(C)N(CCCO)c1nc(Cl)ncc1F,hydroxyl
1763,Please remove a benzene_ring from the molecule CCCC(=O)Nc1cccc(CNC(=O)N2CCSCC2)c1.,CCCC(=O)Nc1cccc(CNC(=O)N2CCSCC2)c1,benzene_ring
66523,Please remove a benzene_ring from the molecule CCC(=O)Nc1cc(NC(C)=O)ccc1C.,CCC(=O)Nc1cc(NC(C)=O)ccc1C,benzene_ring
242130,Remove a amide from the molecule CC[C@H](Sc1nnc(-c2cccc(N)c2)n1C)C(=O)Nc1ccc(Br)cc1.,CC[C@H](Sc1nnc(-c2cccc(N)c2)n1C)C(=O)Nc1ccc(Br)cc1,amide
80489,Modify the molecule COc1ccccc1C(=O)NNC(=O)CCCc1cc(F)ccc1F by removing a benzene_ring.,COc1ccccc1C(=O)NNC(=O)CCCc1cc(F)ccc1F,benzene_ring
32736,Remove a amide from the molecule CCC(=O)NC(=S)N1CCN(C(c2ccccc2)c2ccccc2)CC1.,CCC(=O)NC(=S)N1CCN(C(c2ccccc2)c2ccccc2)CC1,amide
8591,Remove a benzene_ring from the molecule O=S(=O)(Nc1ccccc1Cn1cncn1)c1ccc2ccccc2c1.,O=S(=O)(Nc1ccccc1Cn1cncn1)c1ccc2ccccc2c1,benzene_ring
12773,Modify the molecule Cc1cccc(NC(=O)c2c(N)c(C(=O)c3ccc([N+](=O)[O-])cc3)n3ccccc23)c1 by removing a benzene_ring.,Cc1cccc(NC(=O)c2c(N)c(C(=O)c3ccc([N+](=O)[O-])cc3)n3ccccc23)c1,benzene_ring
93639,Remove a amide from the molecule Cc1cc(=O)c(C(=O)Nc2cnc(C(C)(C)C)nc2)c[nH]1.,Cc1cc(=O)c(C(=O)Nc2cnc(C(C)(C)C)nc2)c[nH]1,amide
193847,Remove a amine from the molecule CCOC(=O)c1cnc(N)nc1C(C)(C)C.,CCOC(=O)c1cnc(N)nc1C(C)(C)C,amine
226015,Please remove a benzene_ring from the molecule C[C@](C(=O)[O-])(c1cc(F)cc(F)c1)[NH+]1CCCC1.,C[C@](C(=O)[O-])(c1cc(F)cc(F)c1)[NH+]1CCCC1,benzene_ring
202885,Remove a amide from the molecule CC(C)(C)[C@@H](NC(=O)Cn1ccnc1)c1cccs1.,CC(C)(C)[C@@H](NC(=O)Cn1ccnc1)c1cccs1,amide
136996,Remove a amide from the molecule C[S@@](=O)Cc1cccc(C(=O)NCC(=O)Nc2nccs2)c1.,C[S@@](=O)Cc1cccc(C(=O)NCC(=O)Nc2nccs2)c1,amide
98027,Modify the molecule COc1ccccc1/C=C/C(=O)OCC(=O)c1ccc2c(c1)OCCO2 by removing a benzene_ring.,COc1ccccc1/C=C/C(=O)OCC(=O)c1ccc2c(c1)OCCO2,benzene_ring
86084,Modify the molecule Nc1c(S(=O)(=O)c2cccs2)c2nc3ccccc3nc2n1/N=C/c1c[nH]c2ccccc12 by removing a amine.,Nc1c(S(=O)(=O)c2cccs2)c2nc3ccccc3nc2n1/N=C/c1c[nH]c2ccccc12,amine
69777,Modify the molecule CCCNc1ncnc2c1cnn2CCNC(=O)c1cc(Br)ccc1Cl by removing a halo.,CCCNc1ncnc2c1cnn2CCNC(=O)c1cc(Br)ccc1Cl,halo
93026,Modify the molecule Cc1noc(C)c1[C@H](C)NC(=O)C(=O)Nc1cnc2ccccc2c1 by removing a amide.,Cc1noc(C)c1[C@H](C)NC(=O)C(=O)Nc1cnc2ccccc2c1,amide
56332,Remove a amide from the molecule O=C(c1ccc(-n2cncn2)cc1)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1.,O=C(c1ccc(-n2cncn2)cc1)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1,amide
149513,Remove a amide from the molecule Cc1occc1C(=O)NCC(=O)N1CC[C@@H](C)[C@H](O)C1.,Cc1occc1C(=O)NCC(=O)N1CC[C@@H](C)[C@H](O)C1,amide
67684,Please remove a benzene_ring from the molecule Oc1cccc([C@H]2c3[nH+]c[nH]c3CCN2Cc2ccnn2-c2ccccc2)c1.,Oc1cccc([C@H]2c3[nH+]c[nH]c3CCN2Cc2ccnn2-c2ccccc2)c1,benzene_ring
126898,Remove a amide from the molecule C[C@H](Sc1ccccn1)C(=O)N[C@H](CO)c1cc(F)c(F)c(F)c1.,C[C@H](Sc1ccccn1)C(=O)N[C@H](CO)c1cc(F)c(F)c(F)c1,amide
59462,Modify the molecule CC(C)(C)c1ccc(Cn2c(CN3CCOCC3)nc3ccccc3c2=O)cc1 by removing a benzene_ring.,CC(C)(C)c1ccc(Cn2c(CN3CCOCC3)nc3ccccc3c2=O)cc1,benzene_ring
121461,Modify the molecule CC[NH+]1CCN(CCNC(=O)CC[C@H]2Cc3ccccc3NC2=O)CC1 by removing a amide.,CC[NH+]1CCN(CCNC(=O)CC[C@H]2Cc3ccccc3NC2=O)CC1,amide
128773,Modify the molecule CC[C@]1(c2ccccc2)NC(=O)N(C[C@@H](O)c2ccccc2Cl)C1=O by removing a benzene_ring.,CC[C@]1(c2ccccc2)NC(=O)N(C[C@@H](O)c2ccccc2Cl)C1=O,benzene_ring
125691,Remove a amine from the molecule CC(C)COCCNC(=O)NNc1ccccc1Cl.,CC(C)COCCNC(=O)NNc1ccccc1Cl,amine
157069,Modify the molecule CC(C)CC(=O)Nc1ccc(NC(=O)N2CCO[C@H](c3cccc(F)c3)C2)cc1 by removing a amide.,CC(C)CC(=O)Nc1ccc(NC(=O)N2CCO[C@H](c3cccc(F)c3)C2)cc1,amide
178314,Remove a benzene_ring from the molecule O=C([O-])c1ccccc1S[C@H]1CCOC2(CCCCC2)C1.,O=C([O-])c1ccccc1S[C@H]1CCOC2(CCCCC2)C1,benzene_ring
199628,Please remove a hydroxyl from the molecule COc1ccc(NC(=O)N[C@H](CO)CC(C)C)cc1OC.,COc1ccc(NC(=O)N[C@H](CO)CC(C)C)cc1OC,hydroxyl
137735,Remove a benzene_ring from the molecule COc1ccc(-c2cc(C(=O)N[C@@H]3CCc4ccccc43)n[nH]2)c(OC)c1.,COc1ccc(-c2cc(C(=O)N[C@@H]3CCc4ccccc43)n[nH]2)c(OC)c1,benzene_ring
122208,Please remove a amide from the molecule CC(C)N1C(=O)C=C(c2ccc(Cl)cc2)Nc2cc([N+](=O)[O-])ccc21.,CC(C)N1C(=O)C=C(c2ccc(Cl)cc2)Nc2cc([N+](=O)[O-])ccc21,amide
151603,Modify the molecule CN(CCc1cccs1)C(=O)c1cccc(CC#N)c1 by removing a nitrile.,CN(CCc1cccs1)C(=O)c1cccc(CC#N)c1,nitrile
221740,Remove a amide from the molecule O=C(Nc1ccc(C[NH2+]Cc2cccc3cccnc23)cc1)c1ccco1.,O=C(Nc1ccc(C[NH2+]Cc2cccc3cccnc23)cc1)c1ccco1,amide
27912,Remove a benzene_ring from the molecule Cc1cccc(N2CCN(C(=O)C[NH+](C)CCO)CC2)c1.,Cc1cccc(N2CCN(C(=O)C[NH+](C)CCO)CC2)c1,benzene_ring
145464,Remove a halo from the molecule N#C/C(=C\c1cc2c(cc1Br)OCO2)c1nc2ccccc2[nH]1.,N#C/C(=C\c1cc2c(cc1Br)OCO2)c1nc2ccccc2[nH]1,halo
197754,Modify the molecule O=C1CCC(=O)N1CCN1CC[NH+](Cc2ccoc2)CC1 by removing a amide.,O=C1CCC(=O)N1CCN1CC[NH+](Cc2ccoc2)CC1,amide
181377,Modify the molecule CC(C)Cc1ccc([C@@H](C)C(=O)N[C@H](C(=O)[O-])C(C)C)cc1 by removing a amide.,CC(C)Cc1ccc([C@@H](C)C(=O)N[C@H](C(=O)[O-])C(C)C)cc1,amide
121187,Modify the molecule COc1cccc(-c2noc(-c3ccc(OC(C)C)cc3)n2)c1 by removing a benzene_ring.,COc1cccc(-c2noc(-c3ccc(OC(C)C)cc3)n2)c1,benzene_ring
178868,Remove a benzene_ring from the molecule CC(C)[C@H](C)CC(=O)Nc1ccccc1CN1C[C@@H](C)O[C@H](C)C1.,CC(C)[C@H](C)CC(=O)Nc1ccccc1CN1C[C@@H](C)O[C@H](C)C1,benzene_ring
68583,Remove a halo from the molecule Cc1nc([C@@H]2CCN(C(=O)C3(c4ccc(Cl)cc4)CCOCC3)C2)ncc1C(N)=O.,Cc1nc([C@@H]2CCN(C(=O)C3(c4ccc(Cl)cc4)CCOCC3)C2)ncc1C(N)=O,halo
52317,Modify the molecule Cc1ccc(F)c(CN2CCC(=O)NC[C@H]2C)c1Cl by removing a benzene_ring.,Cc1ccc(F)c(CN2CCC(=O)NC[C@H]2C)c1Cl,benzene_ring
49331,Remove a amide from the molecule NC(=O)[C@@H]1CCCC[NH+]1CC(=O)NC(=O)NCC(F)(F)F.,NC(=O)[C@@H]1CCCC[NH+]1CC(=O)NC(=O)NCC(F)(F)F,amide
74951,Remove a nitrile from the molecule CC(C)c1ccc(C#N)c(SCC(=O)c2c([O-])on[n+]2C)n1.,CC(C)c1ccc(C#N)c(SCC(=O)c2c([O-])on[n+]2C)n1,nitrile
236839,Remove a amide from the molecule Cc1nc(N(C)C)ncc1C(=O)N[C@H]1Cc2ccccc2[C@@H]1[NH3+].,Cc1nc(N(C)C)ncc1C(=O)N[C@H]1Cc2ccccc2[C@@H]1[NH3+],amide
145218,Please remove a halo from the molecule Cc1nn(C)c(C)c1[C@H](NC(=O)Nc1cccc2ccccc12)C(F)(F)F.,Cc1nn(C)c(C)c1[C@H](NC(=O)Nc1cccc2ccccc12)C(F)(F)F,halo
206787,Modify the molecule N#Cc1cccc(S(=O)(=O)N[C@H](C#N)c2ccc(Cl)cc2)c1 by removing a amine.,N#Cc1cccc(S(=O)(=O)N[C@H](C#N)c2ccc(Cl)cc2)c1,amine
122722,Modify the molecule CCOc1cc(/C=C/C(=O)c2scnc2C)cc(Cl)c1O by removing a benzene_ring.,CCOc1cc(/C=C/C(=O)c2scnc2C)cc(Cl)c1O,benzene_ring
161657,Remove a benzene_ring from the molecule Cc1cc(=O)n2c(n1)SC[C@H]2CC(=O)Nc1cccc(Cl)c1.,Cc1cc(=O)n2c(n1)SC[C@H]2CC(=O)Nc1cccc(Cl)c1,benzene_ring
96598,Remove a amide from the molecule CCNC(=O)[C@H]1CCCN(C(=O)N[C@@H](C)CSC)C1.,CCNC(=O)[C@H]1CCCN(C(=O)N[C@@H](C)CSC)C1,amide
177794,Please remove a halo from the molecule Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)Nc4ccc(Br)c(C)c4)C3)ncn2)n1.,Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)Nc4ccc(Br)c(C)c4)C3)ncn2)n1,halo
85808,Remove a amide from the molecule O=C(CCN1CCCC1=O)NCC1([NH+]2CCCCC2)CCOCC1.,O=C(CCN1CCCC1=O)NCC1([NH+]2CCCCC2)CCOCC1,amide
83334,Please remove a amide from the molecule O=C(NCC(=O)N1CCN(Cc2ccccn2)CC1)NC1CCCCC1.,O=C(NCC(=O)N1CCN(Cc2ccccn2)CC1)NC1CCCCC1,amide
50140,Please remove a amide from the molecule Cc1cccc(C(=O)N2CCCC2)c1NC(=O)NCc1ccccc1F.,Cc1cccc(C(=O)N2CCCC2)c1NC(=O)NCc1ccccc1F,amide
143410,Modify the molecule COc1ccc(OC)c([C@@H]2CCCN2C(=O)c2ccoc2)c1 by removing a amide.,COc1ccc(OC)c([C@@H]2CCCN2C(=O)c2ccoc2)c1,amide
182728,Modify the molecule C[C@@H](C(=O)Nc1ccccc1C(C)(C)C)N1CC[NH+](CCO)CC1 by removing a hydroxyl.,C[C@@H](C(=O)Nc1ccccc1C(C)(C)C)N1CC[NH+](CCO)CC1,hydroxyl
211513,Remove a halo from the molecule COC[C@@H]1CCN(c2cc(C)c(F)cc2[C@H](C)[NH3+])C1.,COC[C@@H]1CCN(c2cc(C)c(F)cc2[C@H](C)[NH3+])C1,halo
212510,Modify the molecule COc1ccc([C@H]2CCN(C(=O)NCc3cccc(OCC(F)F)n3)C2)cc1 by removing a halo.,COc1ccc([C@H]2CCN(C(=O)NCc3cccc(OCC(F)F)n3)C2)cc1,halo
41465,Modify the molecule CC(C)C(=O)Nc1cccc(C(=O)Nc2ccccc2)c1 by removing a benzene_ring.,CC(C)C(=O)Nc1cccc(C(=O)Nc2ccccc2)c1,benzene_ring
47190,Remove a amide from the molecule CC[C@H]1COCCN1C(=O)c1ccc2[nH]c(C)c(C)c2c1.,CC[C@H]1COCCN1C(=O)c1ccc2[nH]c(C)c(C)c2c1,amide
26844,Modify the molecule O=C(Cn1nc2c(cc1=O)CCCC2)N1CC[C@]2(O)CCCC[C@@H]2C1 by removing a hydroxyl.,O=C(Cn1nc2c(cc1=O)CCCC2)N1CC[C@]2(O)CCCC[C@@H]2C1,hydroxyl
32571,Remove a amide from the molecule Cc1cc(C)cc(NC(=S)NC(=O)c2cccc(F)c2)c1.,Cc1cc(C)cc(NC(=S)NC(=O)c2cccc(F)c2)c1,amide
214318,Remove a benzene_ring from the molecule O=C(Nc1ccc(F)c(F)c1F)c1ccc([N+](=O)[O-])o1.,O=C(Nc1ccc(F)c(F)c1F)c1ccc([N+](=O)[O-])o1,benzene_ring
163014,Remove a amine from the molecule CCOc1ccc(Nc2nc(CSc3nc4ccccc4o3)cc(=O)[nH]2)cc1.,CCOc1ccc(Nc2nc(CSc3nc4ccccc4o3)cc(=O)[nH]2)cc1,amine
154572,Modify the molecule CC(C)[NH+](C)CCCCn1c([C@H](C)Cl)nc2cnccc21 by removing a halo.,CC(C)[NH+](C)CCCCn1c([C@H](C)Cl)nc2cnccc21,halo
179508,Please remove a benzene_ring from the molecule COc1cc(C(=O)N(C)Cc2ccccc2OC(F)(F)F)cc(OC)c1C.,COc1cc(C(=O)N(C)Cc2ccccc2OC(F)(F)F)cc(OC)c1C,benzene_ring
159885,Please remove a benzene_ring from the molecule NC(=O)[C@]1([NH3+])CCC[C@H]1CCSc1ccc(Br)cc1.,NC(=O)[C@]1([NH3+])CCC[C@H]1CCSc1ccc(Br)cc1,benzene_ring
151171,Modify the molecule Cc1ccc(Cl)c(O[C@H](C)C(=O)NCCCc2ccccc2)c1 by removing a amide.,Cc1ccc(Cl)c(O[C@H](C)C(=O)NCCCc2ccccc2)c1,amide
239650,Please remove a benzene_ring from the molecule COc1ccccc1CNC(=O)Nc1ccc(N2CC[NH+](C)CC2)cc1C.,COc1ccccc1CNC(=O)Nc1ccc(N2CC[NH+](C)CC2)cc1C,benzene_ring
86230,Remove a halo from the molecule N#Cc1nc(/C=C/c2ccccc2Cl)oc1N1CCN(C(=O)c2cccc(Cl)c2)CC1.,N#Cc1nc(/C=C/c2ccccc2Cl)oc1N1CCN(C(=O)c2cccc(Cl)c2)CC1,halo
103200,Please remove a benzene_ring from the molecule CCOc1ccc(OCC(=O)Oc2ccc3c4c(c(=O)oc3c2)CCC4)cc1.,CCOc1ccc(OCC(=O)Oc2ccc3c4c(c(=O)oc3c2)CCC4)cc1,benzene_ring
191604,Modify the molecule CS(=O)(=O)Cc1cn2cc(Cl)cc(Cl)c2n1 by removing a halo.,CS(=O)(=O)Cc1cn2cc(Cl)cc(Cl)c2n1,halo
6363,Please remove a halo from the molecule COc1ccc(C(=O)CCC(=O)N2C[C@@H](C)OC[C@@H]2C)cc1F.,COc1ccc(C(=O)CCC(=O)N2C[C@@H](C)OC[C@@H]2C)cc1F,halo
8350,Remove a amide from the molecule Cc1oc2c(c1C(=O)NCCNC(=O)c1c(C)oc3c1CCCC3)CCCC2.,Cc1oc2c(c1C(=O)NCCNC(=O)c1c(C)oc3c1CCCC3)CCCC2,amide
97802,Please remove a amide from the molecule O=C(C[NH+](Cc1ccco1)C1CCCC1)NCc1cccnc1.,O=C(C[NH+](Cc1ccco1)C1CCCC1)NCc1cccnc1,amide
158213,Modify the molecule CC(C)NC(=O)c1ccc(NCc2ccc(F)c(Br)c2)cc1 by removing a halo.,CC(C)NC(=O)c1ccc(NCc2ccc(F)c(Br)c2)cc1,halo
105398,Please remove a benzene_ring from the molecule Cc1ccc([C@@H](C)NC(=O)N[C@H](CCCO)c2ccccc2)cc1F.,Cc1ccc([C@@H](C)NC(=O)N[C@H](CCCO)c2ccccc2)cc1F,benzene_ring
67835,Please remove a halo from the molecule O=[N+]([O-])/C=C/c1c(F)c(F)c(F)c(F)c1F.,O=[N+]([O-])/C=C/c1c(F)c(F)c(F)c(F)c1F,halo
120941,Please remove a amide from the molecule CNC(=O)c1cccc(N2CCN(Cc3cccs3)CC2)n1.,CNC(=O)c1cccc(N2CCN(Cc3cccs3)CC2)n1,amide
170570,Remove a benzene_ring from the molecule COc1ccc(CN2CCS(=O)(=O)[C@H](C)[C@H]2C)c(OC)c1.,COc1ccc(CN2CCS(=O)(=O)[C@H](C)[C@H]2C)c(OC)c1,benzene_ring
72154,Remove a amide from the molecule C[C@H]1C[C@@H](C)CN(C(=O)C[NH+](C)CC2CC[NH2+]CC2)C1.,C[C@H]1C[C@@H](C)CN(C(=O)C[NH+](C)CC2CC[NH2+]CC2)C1,amide
4895,Modify the molecule CC(C)CCC(=O)NNC(=O)NC[C@H](C)c1ccsc1 by removing a amide.,CC(C)CCC(=O)NNC(=O)NC[C@H](C)c1ccsc1,amide
223555,Modify the molecule CC(=O)N[C@@]1(C(F)(F)F)NC(=O)N(C)C1=O by removing a halo.,CC(=O)N[C@@]1(C(F)(F)F)NC(=O)N(C)C1=O,halo
237778,Please remove a amide from the molecule CC[C@@H](NC(=O)C1C[C@H](C)O[C@H](C)C1)c1ccc(Br)cc1.,CC[C@@H](NC(=O)C1C[C@H](C)O[C@H](C)C1)c1ccc(Br)cc1,amide
183034,Remove a benzene_ring from the molecule COc1cc(OC)cc([C@H]2CCN(C(=O)c3c(F)cccc3Cl)C2)c1.,COc1cc(OC)cc([C@H]2CCN(C(=O)c3c(F)cccc3Cl)C2)c1,benzene_ring
243646,Remove a benzene_ring from the molecule CC[C@H](NC(=O)N(C)[C@H](CC)CSC)c1ccc(F)cc1F.,CC[C@H](NC(=O)N(C)[C@H](CC)CSC)c1ccc(F)cc1F,benzene_ring
239998,Please remove a amide from the molecule CCn1c(SCC(=O)Nc2c(C)cccc2C)nc2sc(C)c(C)c2c1=O.,CCn1c(SCC(=O)Nc2c(C)cccc2C)nc2sc(C)c(C)c2c1=O,amide
83856,Remove a amide from the molecule CCc1cccc(C)c1NC(=O)c1cnc(SC)nc1-c1ccccc1.,CCc1cccc(C)c1NC(=O)c1cnc(SC)nc1-c1ccccc1,amide
3664,Please remove a benzene_ring from the molecule O=[S@@](Cc1csc(-c2ccc(F)cc2)n1)c1cccc(F)c1.,O=[S@@](Cc1csc(-c2ccc(F)cc2)n1)c1cccc(F)c1,benzene_ring
32914,Please remove a nitro from the molecule C[C@H]1OCC[C@@H]1C(=O)NCCOc1ccc([N+](=O)[O-])cc1.,C[C@H]1OCC[C@@H]1C(=O)NCCOc1ccc([N+](=O)[O-])cc1,nitro
222205,Please remove a benzene_ring from the molecule Cc1ccccc1CC(=O)N1CCN([C@@H](C)c2nc(C3CC3)no2)CC1.,Cc1ccccc1CC(=O)N1CCN([C@@H](C)c2nc(C3CC3)no2)CC1,benzene_ring
43312,Modify the molecule O=C(Cc1cn2ccsc2n1)N[C@H]1CCC[C@H]1Cc1ccccc1 by removing a amide.,O=C(Cc1cn2ccsc2n1)N[C@H]1CCC[C@H]1Cc1ccccc1,amide
40686,Please remove a benzene_ring from the molecule CC[C@H](C#N)OC(=O)/C=C/c1c(F)cccc1F.,CC[C@H](C#N)OC(=O)/C=C/c1c(F)cccc1F,benzene_ring
81567,Remove a amine from the molecule NC(=S)N/N=C1C(=N/N=C(\N)[S-])\Sc2ccccc2\1.,NC(=S)N/N=C1C(=N/N=C(\N)[S-])\Sc2ccccc2\1,amine
208886,Please remove a halo from the molecule O=C(NC1(C(=O)[O-])CCCCC1)c1c[nH]c(=O)c(Cl)c1.,O=C(NC1(C(=O)[O-])CCCCC1)c1c[nH]c(=O)c(Cl)c1,halo
77605,Please remove a hydroxyl from the molecule OC1CC23CCCCCCC2(C1)CC(O)C3.,OC1CC23CCCCCCC2(C1)CC(O)C3,hydroxyl
244921,Modify the molecule CCCC(=O)N(C)Cc1c(CC)oc2ccccc12 by removing a amide.,CCCC(=O)N(C)Cc1c(CC)oc2ccccc12,amide
43812,Remove a amide from the molecule Cc1cccc(CN2CCN(C(=O)c3cc(C#N)cn3C)CC2)c1.,Cc1cccc(CN2CCN(C(=O)c3cc(C#N)cn3C)CC2)c1,amide
62948,Modify the molecule COc1cccc(-c2nc(Cn3cnc(C4CCC4)cc3=O)cs2)c1 by removing a benzene_ring.,COc1cccc(-c2nc(Cn3cnc(C4CCC4)cc3=O)cs2)c1,benzene_ring
74799,Modify the molecule CCCCN(C)S(=O)(=O)N1CCO[C@H](c2cccc(F)c2)C1 by removing a benzene_ring.,CCCCN(C)S(=O)(=O)N1CCO[C@H](c2cccc(F)c2)C1,benzene_ring
157059,Modify the molecule C[C@H]1CCC[C@@]2(CC[NH2+]C[C@@H]2c2ccccc2F)C1 by removing a halo.,C[C@H]1CCC[C@@]2(CC[NH2+]C[C@@H]2c2ccccc2F)C1,halo
18945,Please remove a benzene_ring from the molecule Cc1ccc(C(N)=O)cc1NC(=O)N(Cc1cccc(F)c1)C[C@H]1CCCO1.,Cc1ccc(C(N)=O)cc1NC(=O)N(Cc1cccc(F)c1)C[C@H]1CCCO1,benzene_ring
141615,Please remove a amide from the molecule CSc1nc(-c2ccco2)nc(C)c1C(=O)NCC[C@@H](O)C(C)C.,CSc1nc(-c2ccco2)nc(C)c1C(=O)NCC[C@@H](O)C(C)C,amide
83667,Please remove a benzene_ring from the molecule C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)c1ccc2c(c1)C(=O)N(C)C2=O.,C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)c1ccc2c(c1)C(=O)N(C)C2=O,benzene_ring
47958,Please remove a benzene_ring from the molecule CCc1nn(C)cc1CNC(=O)Nc1cc(C)ccc1-n1cc(C)cn1.,CCc1nn(C)cc1CNC(=O)Nc1cc(C)ccc1-n1cc(C)cn1,benzene_ring
208872,Remove a amide from the molecule CC(=O)c1ccc(-c2cc(F)cc3c2O[C@H](CNC(=O)[C@@H]2CCOC(C)(C)C2)C3)s1.,CC(=O)c1ccc(-c2cc(F)cc3c2O[C@H](CNC(=O)[C@@H]2CCOC(C)(C)C2)C3)s1,amide
195234,Please remove a amine from the molecule COc1ccccc1NS(=O)(=O)c1cc(NC(=O)c2ccco2)ccc1N1CCOCC1.,COc1ccccc1NS(=O)(=O)c1cc(NC(=O)c2ccco2)ccc1N1CCOCC1,amine
42563,Modify the molecule Cc1ccc(NC(=O)C2([NH+](C)C)CCC2)cc1S(C)(=O)=O by removing a benzene_ring.,Cc1ccc(NC(=O)C2([NH+](C)C)CCC2)cc1S(C)(=O)=O,benzene_ring
37423,Remove a halo from the molecule O=S(=O)(NCc1ccccc1)c1ccccc1Br.,O=S(=O)(NCc1ccccc1)c1ccccc1Br,halo
212465,Modify the molecule C[C@@H](C1CC1)N(C(=O)CSc1nc2c(cc1C#N)CCCC2)C1CC1 by removing a amide.,C[C@@H](C1CC1)N(C(=O)CSc1nc2c(cc1C#N)CCCC2)C1CC1,amide
92005,Remove a amide from the molecule CCOc1cccc2sc(NC(=O)[C@H]3CCCN(S(=O)(=O)c4ccc(C)cc4)C3)nc12.,CCOc1cccc2sc(NC(=O)[C@H]3CCCN(S(=O)(=O)c4ccc(C)cc4)C3)nc12,amide
68526,Please remove a halo from the molecule COc1cccc2cc(C(=O)N3CCN(C(=O)[C@@H]4C[C@H]4c4ccc(F)cc4)CC3)oc12.,COc1cccc2cc(C(=O)N3CCN(C(=O)[C@@H]4C[C@H]4c4ccc(F)cc4)CC3)oc12,halo
166176,Please remove a halo from the molecule COc1ccc(Br)cc1C[NH2+]C1CCC(O)CC1.,COc1ccc(Br)cc1C[NH2+]C1CCC(O)CC1,halo
240940,Remove a benzene_ring from the molecule Cc1ccc(-c2nc(N3C[C@H](C)O[C@H](C)C3)ncc2-c2cncnc2)cc1.,Cc1ccc(-c2nc(N3C[C@H](C)O[C@H](C)C3)ncc2-c2cncnc2)cc1,benzene_ring
100052,Please remove a amide from the molecule NC(=O)NC[C@H]1CCCCN1C(=O)CCCC1CCCC1.,NC(=O)NC[C@H]1CCCCN1C(=O)CCCC1CCCC1,amide
94335,Please remove a halo from the molecule O=C(Cn1nc2c(c1NC(=O)c1cc3ccccc3o1)CSC2)NCc1ccc(F)cc1.,O=C(Cn1nc2c(c1NC(=O)c1cc3ccccc3o1)CSC2)NCc1ccc(F)cc1,halo
249267,Modify the molecule CCc1nnc(SCCOc2ccc(F)cc2Cl)n1N by removing a amine.,CCc1nnc(SCCOc2ccc(F)cc2Cl)n1N,amine
162401,Please remove a amide from the molecule COC(=O)c1ccc(F)c(NC(=O)[C@@H]2CCO[C@H]2C)c1.,COC(=O)c1ccc(F)c(NC(=O)[C@@H]2CCO[C@H]2C)c1,amide
4563,Modify the molecule OCCC#Cc1cc(F)cc(C[NH+]2CCC[C@H]2CO)c1 by removing a halo.,OCCC#Cc1cc(F)cc(C[NH+]2CCC[C@H]2CO)c1,halo
94266,Remove a halo from the molecule COc1cc(OC)c(N/C([O-])=C2/Oc3ccccc3NC2=O)cc1Cl.,COc1cc(OC)c(N/C([O-])=C2/Oc3ccccc3NC2=O)cc1Cl,halo
219633,Please remove a benzene_ring from the molecule Cc1ccc2c(c1)N(C(=O)N1CCC(C(=O)Nc3ccccc3Cl)CC1)CCO2.,Cc1ccc2c(c1)N(C(=O)N1CCC(C(=O)Nc3ccccc3Cl)CC1)CCO2,benzene_ring
189934,Modify the molecule Cc1c(Cl)cccc1NS(=O)(=O)c1ccc2c(c1)NC(=O)[C@H](C)C(=O)N2 by removing a benzene_ring.,Cc1c(Cl)cccc1NS(=O)(=O)c1ccc2c(c1)NC(=O)[C@H](C)C(=O)N2,benzene_ring
226551,Remove a amide from the molecule COc1cccc(NC(=O)CSc2nccn(-c3ccc(C)c(C)c3)c2=O)c1.,COc1cccc(NC(=O)CSc2nccn(-c3ccc(C)c(C)c3)c2=O)c1,amide
181257,Remove a benzene_ring from the molecule COc1cccc([C@H]2CC(=O)NC3=C2C(=O)C[C@H](c2cc(OC)c(OC)c(OC)c2)C3)c1.,COc1cccc([C@H]2CC(=O)NC3=C2C(=O)C[C@H](c2cc(OC)c(OC)c(OC)c2)C3)c1,benzene_ring
129622,Modify the molecule O=C(c1csc(-c2ccnc(N3CCCC3)c2)n1)N1CCN(c2ccccc2F)CC1 by removing a halo.,O=C(c1csc(-c2ccnc(N3CCCC3)c2)n1)N1CCN(c2ccccc2F)CC1,halo
46565,Modify the molecule Cc1noc(C)c1CN1CCN(C(=O)c2ccc(N(C)C)nc2)CC1 by removing a amide.,Cc1noc(C)c1CN1CCN(C(=O)c2ccc(N(C)C)nc2)CC1,amide
67854,Remove a benzene_ring from the molecule C[C@H]([NH2+]CCO)c1cc(F)cc(F)c1.,C[C@H]([NH2+]CCO)c1cc(F)cc(F)c1,benzene_ring
67216,Modify the molecule CCn1nc(CC(C)C)cc1C(=O)N1C[C@H]2CC=C(C)C[C@H]2C1 by removing a amide.,CCn1nc(CC(C)C)cc1C(=O)N1C[C@H]2CC=C(C)C[C@H]2C1,amide
155846,Please remove a benzene_ring from the molecule COc1ccc2c(CC(=O)N(C)[C@H](C)c3ccc(F)cc3)coc2c1.,COc1ccc2c(CC(=O)N(C)[C@H](C)c3ccc(F)cc3)coc2c1,benzene_ring
34452,Please remove a halo from the molecule CCOC(=N)Cc1ccc(Cl)c(Cl)c1.,CCOC(=N)Cc1ccc(Cl)c(Cl)c1,halo
55774,Please remove a amine from the molecule Cc1ccc(S(=O)(=O)N[C@@H](C)C(=O)N2CCC2)cc1.,Cc1ccc(S(=O)(=O)N[C@@H](C)C(=O)N2CCC2)cc1,amine
238822,Remove a amide from the molecule CC(=O)Nc1nc2ccc(NC(=O)NCCC(C)C)cc2s1.,CC(=O)Nc1nc2ccc(NC(=O)NCCC(C)C)cc2s1,amide
179992,Modify the molecule CC(C)C[C@@H](C(=O)OCc1cccnc1)N1CCCCC1=O by removing a amide.,CC(C)C[C@@H](C(=O)OCc1cccnc1)N1CCCCC1=O,amide
169405,Modify the molecule CCOC(=O)[C@@]1(N)CC[C@H]([NH+]2C[C@@H](C)[C@@H](C)C2)C1 by removing a amine.,CCOC(=O)[C@@]1(N)CC[C@H]([NH+]2C[C@@H](C)[C@@H](C)C2)C1,amine
126937,Please remove a benzene_ring from the molecule COC(=O)[C@H]1CCN(C(=O)Cc2cccc(OCc3cccnc3)c2)C1.,COC(=O)[C@H]1CCN(C(=O)Cc2cccc(OCc3cccnc3)c2)C1,benzene_ring
158399,Please remove a amine from the molecule Cc1cccc(NC2CC[NH+]([C@H](C)C(=O)Nc3cc(C)on3)CC2)[nH+]1.,Cc1cccc(NC2CC[NH+]([C@H](C)C(=O)Nc3cc(C)on3)CC2)[nH+]1,amine
195187,Modify the molecule O=C(Nc1nnn[n-]1)c1cc2ccccc2s1 by removing a amide.,O=C(Nc1nnn[n-]1)c1cc2ccccc2s1,amide
92023,Please remove a halo from the molecule O=C(CCn1ccc2cc(Br)ccc21)/N=C1\N=N[C@H]([C@H]2CCCO2)S1.,O=C(CCn1ccc2cc(Br)ccc21)/N=C1\N=N[C@H]([C@H]2CCCO2)S1,halo
74534,Remove a benzene_ring from the molecule C[C@H](Cc1ccccc1F)C(=O)N[C@H]1CC[C@H]([NH+](C)C)C1.,C[C@H](Cc1ccccc1F)C(=O)N[C@H]1CC[C@H]([NH+](C)C)C1,benzene_ring
224495,Please remove a benzene_ring from the molecule O=C(CN1CCN(c2ncccn2)CC1)Nc1ccc(Br)cc1.,O=C(CN1CCN(c2ncccn2)CC1)Nc1ccc(Br)cc1,benzene_ring
224522,Please remove a amide from the molecule CCOC(=O)c1ccc(CNC(=O)c2cc(-c3csc(C)n3)c[nH]2)o1.,CCOC(=O)c1ccc(CNC(=O)c2cc(-c3csc(C)n3)c[nH]2)o1,amide
122303,Remove a benzene_ring from the molecule N/C(=N/OCCCOc1ccccc1)c1ccc(F)c(F)c1.,N/C(=N/OCCCOc1ccccc1)c1ccc(F)c(F)c1,benzene_ring
216404,Remove a benzene_ring from the molecule Fc1ccccc1[C@@H]1C[C@H](c2ccc(Cl)cc2)Nc2nnnn21.,Fc1ccccc1[C@@H]1C[C@H](c2ccc(Cl)cc2)Nc2nnnn21,benzene_ring
45888,Modify the molecule COCCOc1ccc(NC(=O)C(=O)N[C@@H]2CCC[C@H](C)[C@H]2C)cc1 by removing a benzene_ring.,COCCOc1ccc(NC(=O)C(=O)N[C@@H]2CCC[C@H](C)[C@H]2C)cc1,benzene_ring
4692,Modify the molecule O=C(Cc1ccc(N2CCCC2=O)cc1)Nn1cnc2ccccc2c1=O by removing a benzene_ring.,O=C(Cc1ccc(N2CCCC2=O)cc1)Nn1cnc2ccccc2c1=O,benzene_ring
121485,Modify the molecule Cc1nc2ccccc2n1CCCNC(=O)c1ccc(-n2cccc2)nc1 by removing a amide.,Cc1nc2ccccc2n1CCCNC(=O)c1ccc(-n2cccc2)nc1,amide
208837,Please remove a amine from the molecule CCOC(=O)/C=C1\NCCCN1Cc1ccccc1Cl.,CCOC(=O)/C=C1\NCCCN1Cc1ccccc1Cl,amine
95056,Please remove a benzene_ring from the molecule Cc1nc(C[NH+]2CCN(Cc3cccc(F)c3)CC2)co1.,Cc1nc(C[NH+]2CCN(Cc3cccc(F)c3)CC2)co1,benzene_ring
12608,Modify the molecule CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)CNC(=O)Cc1ccccc1 by removing a benzene_ring.,CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)CNC(=O)Cc1ccccc1,benzene_ring
118482,Remove a amide from the molecule CCc1c(C)nn(CCNC(=O)c2cn[nH]n2)c1C.,CCc1c(C)nn(CCNC(=O)c2cn[nH]n2)c1C,amide
65368,Modify the molecule Cc1cc(N(C)C)cc(C)c1NC(=O)c1ccnc(OC(C)(C)C)c1 by removing a amide.,Cc1cc(N(C)C)cc(C)c1NC(=O)c1ccnc(OC(C)(C)C)c1,amide
122401,Please remove a benzene_ring from the molecule C[C@@H](Oc1ccc(N(C)S(C)(=O)=O)cc1)C(=O)NC1CC[NH+](C)CC1.,C[C@@H](Oc1ccc(N(C)S(C)(=O)=O)cc1)C(=O)NC1CC[NH+](C)CC1,benzene_ring
147603,Please remove a nitro from the molecule Cn1ncc2nc3cc([N+](=O)[O-])ccc3c([O-])c21.,Cn1ncc2nc3cc([N+](=O)[O-])ccc3c([O-])c21,nitro
91759,Remove a benzene_ring from the molecule CC(C)[C@H](CO)[NH+](Cc1ccccc1)C1CCSCC1.,CC(C)[C@H](CO)[NH+](Cc1ccccc1)C1CCSCC1,benzene_ring
96766,Modify the molecule CCn1c(C)cc(C(=O)Nc2ccc(N3C(=O)CCCC3=O)cc2)c1C by removing a benzene_ring.,CCn1c(C)cc(C(=O)Nc2ccc(N3C(=O)CCCC3=O)cc2)c1C,benzene_ring
136572,Modify the molecule COCCNC(=O)c1ccc(N2CCN(c3ncccc3C#N)CC2)nc1 by removing a nitrile.,COCCNC(=O)c1ccc(N2CCN(c3ncccc3C#N)CC2)nc1,nitrile
129990,Remove a halo from the molecule CC(C)/C(=C\c1cc(Cl)c2c(c1)OCO2)CO.,CC(C)/C(=C\c1cc(Cl)c2c(c1)OCO2)CO,halo
128453,Modify the molecule CCn1cc([C@H]2c3[nH]c4ccc(OC)cc4c3CCN2C(=O)c2ccc(Cl)cc2)cn1 by removing a benzene_ring.,CCn1cc([C@H]2c3[nH]c4ccc(OC)cc4c3CCN2C(=O)c2ccc(Cl)cc2)cn1,benzene_ring
172234,Please remove a amine from the molecule Clc1ccccc1CNCCc1cn2ccccc2n1.,Clc1ccccc1CNCCc1cn2ccccc2n1,amine
149979,Modify the molecule COc1c(F)c(F)cc2c(=O)c(C(=O)NC(C)(C)CO)cn(C3CC3)c12 by removing a hydroxyl.,COc1c(F)c(F)cc2c(=O)c(C(=O)NC(C)(C)CO)cn(C3CC3)c12,hydroxyl
221164,Modify the molecule CCN1CCN(C(=O)c2ccc(OC)nc2)C[C@H](Cc2ccccc2-c2ccncc2)C1=O by removing a amide.,CCN1CCN(C(=O)c2ccc(OC)nc2)C[C@H](Cc2ccccc2-c2ccncc2)C1=O,amide
73559,Modify the molecule CC[C@](C)([C@H](NC)c1ccc(C)s1)[NH+]1CCCC1 by removing a amine.,CC[C@](C)([C@H](NC)c1ccc(C)s1)[NH+]1CCCC1,amine
77452,Modify the molecule Cc1ccc(SCCC(=O)NC2CC[NH+](CC(N)=O)CC2)cc1 by removing a amide.,Cc1ccc(SCCC(=O)NC2CC[NH+](CC(N)=O)CC2)cc1,amide
37491,Please remove a amide from the molecule Cc1ccc(C(=O)N2CCCC2)c(C2CCN(C(=O)c3ccoc3)CC2)n1.,Cc1ccc(C(=O)N2CCCC2)c(C2CCN(C(=O)c3ccoc3)CC2)n1,amide
143530,Remove a benzene_ring from the molecule Cc1ccc(-c2nc(NCC[C@@H]3CCC[NH+]3C)ncc2-c2cncnc2)cc1.,Cc1ccc(-c2nc(NCC[C@@H]3CCC[NH+]3C)ncc2-c2cncnc2)cc1,benzene_ring
239402,Please remove a amine from the molecule COc1ccc(C2=NN3C(=NC(C)=C(C(N)=O)[C@H]3c3ccc4c(c3)OCO4)N2)cc1.,COc1ccc(C2=NN3C(=NC(C)=C(C(N)=O)[C@H]3c3ccc4c(c3)OCO4)N2)cc1,amine
208380,Please remove a amide from the molecule O=C(NCC1CCN(c2nc3ccccc3o2)CC1)c1ccc2ccccc2c1.,O=C(NCC1CCN(c2nc3ccccc3o2)CC1)c1ccc2ccccc2c1,amide
148165,Remove a amine from the molecule Nc1c(Nc2cc(Cl)cc(Cl)c2)ncnc1NC1CCCCC1.,Nc1c(Nc2cc(Cl)cc(Cl)c2)ncnc1NC1CCCCC1,amine
24320,Remove a amine from the molecule Clc1ccc(NCc2ccncn2)cc1Br.,Clc1ccc(NCc2ccncn2)cc1Br,amine
38436,Modify the molecule COc1cccc(O[C@@H](C)CNc2ncccc2C#N)c1 by removing a nitrile.,COc1cccc(O[C@@H](C)CNc2ncccc2C#N)c1,nitrile
74,Remove a benzene_ring from the molecule COc1cccc(CN2CCc3nnc(CCc4ccccc4)n3CC2)c1.,COc1cccc(CN2CCc3nnc(CCc4ccccc4)n3CC2)c1,benzene_ring
175409,Modify the molecule CCN(Cc1ccc(I)cc1)C(F)(F)F by removing a halo.,CCN(Cc1ccc(I)cc1)C(F)(F)F,halo
50483,Please remove a halo from the molecule CC(=O)c1cc(F)ccc1OCC(=O)N[C@H]1CCOc2ccccc21.,CC(=O)c1cc(F)ccc1OCC(=O)N[C@H]1CCOc2ccccc21,halo
8617,Remove a amine from the molecule Nc1nc(CC(=O)N2CCC[C@@H](c3[nH]ncc3-c3ccccc3)C2)cc(=O)[nH]1.,Nc1nc(CC(=O)N2CCC[C@@H](c3[nH]ncc3-c3ccccc3)C2)cc(=O)[nH]1,amine
220002,Modify the molecule COC(=O)c1cccc(C(=O)NCCc2cnn(-c3ccccc3)c2)n1 by removing a benzene_ring.,COC(=O)c1cccc(C(=O)NCCc2cnn(-c3ccccc3)c2)n1,benzene_ring
156324,Please remove a amide from the molecule O=C(Cc1ccc(F)cc1F)NCc1cc(Cl)c2c(c1)OCCO2.,O=C(Cc1ccc(F)cc1F)NCc1cc(Cl)c2c(c1)OCCO2,amide
103224,Modify the molecule CCC(=O)[C@H]1CCCN(C(=O)C[C@@]2(c3ccccc3F)CC(=O)N(C3CCCC3)C2=O)C1 by removing a amide.,CCC(=O)[C@H]1CCCN(C(=O)C[C@@]2(c3ccccc3F)CC(=O)N(C3CCCC3)C2=O)C1,amide
22233,Please remove a benzene_ring from the molecule Cc1cc(C(=O)Nc2c(Cl)cc(Cl)cc2C(=O)[O-])c(C)s1.,Cc1cc(C(=O)Nc2c(Cl)cc(Cl)cc2C(=O)[O-])c(C)s1,benzene_ring
36414,Remove a halo from the molecule O=C(Nc1ccn(Cc2ccccn2)n1)c1c[nH]c2cccc(F)c12.,O=C(Nc1ccn(Cc2ccccn2)n1)c1c[nH]c2cccc(F)c12,halo
134254,Please remove a amine from the molecule CCOC(=O)[C@H](CC(C)C)Nc1ncnc2onc(C)c12.,CCOC(=O)[C@H](CC(C)C)Nc1ncnc2onc(C)c12,amine
108500,Remove a benzene_ring from the molecule Cc1occc1-c1nnc(SCc2cccc(OCC(F)(F)F)c2)n1C.,Cc1occc1-c1nnc(SCc2cccc(OCC(F)(F)F)c2)n1C,benzene_ring
45559,Remove a halo from the molecule C/C(=C\c1ccc(F)cc1)C(=O)O[C@@H](C)c1ccccn1.,C/C(=C\c1ccc(F)cc1)C(=O)O[C@@H](C)c1ccccn1,halo
217017,Modify the molecule Cc1nnc(CN(C(=O)c2nc(C3CC3)n3ccccc23)C(C)(C)C)o1 by removing a amide.,Cc1nnc(CN(C(=O)c2nc(C3CC3)n3ccccc23)C(C)(C)C)o1,amide
45691,Modify the molecule COc1ccccc1[C@H](C)CC(=O)Nc1ccc(N2CCO[C@@H](C)C2)cc1 by removing a benzene_ring.,COc1ccccc1[C@H](C)CC(=O)Nc1ccc(N2CCO[C@@H](C)C2)cc1,benzene_ring
142978,Remove a amide from the molecule CC(C)n1cc[nH+]c1C1CCN(C(=O)c2ccc3[nH]nnc3c2)CC1.,CC(C)n1cc[nH+]c1C1CCN(C(=O)c2ccc3[nH]nnc3c2)CC1,amide
72341,Please remove a amide from the molecule CO[C@H]1C[C@@H](C(=O)[O-])N(C(=O)c2cc(SC)ccc2C)C1.,CO[C@H]1C[C@@H](C(=O)[O-])N(C(=O)c2cc(SC)ccc2C)C1,amide
236180,Please remove a benzene_ring from the molecule O=C(NCC1CCN(c2cc[nH+]cc2)CC1)Nc1c(F)cc(F)cc1F.,O=C(NCC1CCN(c2cc[nH+]cc2)CC1)Nc1c(F)cc(F)cc1F,benzene_ring
230871,Please remove a halo from the molecule C[C@@H]1Cc2cc(S(=O)(=O)Nc3ccc(Br)cc3)ccc2N1.,C[C@@H]1Cc2cc(S(=O)(=O)Nc3ccc(Br)cc3)ccc2N1,halo
77183,Modify the molecule C[C@H](NC(=O)N[C@@](C)(CO)C1CCCCC1)c1ccc(C#N)cc1 by removing a nitrile.,C[C@H](NC(=O)N[C@@](C)(CO)C1CCCCC1)c1ccc(C#N)cc1,nitrile
63725,Please remove a amide from the molecule Cc1c(Cl)cccc1NC(=O)C(=O)N/N=C/c1coc2ccc(Cl)cc2c1=O.,Cc1c(Cl)cccc1NC(=O)C(=O)N/N=C/c1coc2ccc(Cl)cc2c1=O,amide
136221,Modify the molecule C[C@H](O)[C@@H]1CCC[NH+](CC(=O)Nc2ccccc2-c2ccccc2)C1 by removing a benzene_ring.,C[C@H](O)[C@@H]1CCC[NH+](CC(=O)Nc2ccccc2-c2ccccc2)C1,benzene_ring
37184,Please remove a amide from the molecule NC(=O)c1ccc(NC(=O)Cc2csc(NC(=O)c3ccsc3)n2)cc1.,NC(=O)c1ccc(NC(=O)Cc2csc(NC(=O)c3ccsc3)n2)cc1,amide
20753,Modify the molecule O=C(Cc1ccccc1O)N1CCN(S(=O)(=O)c2cc(Cl)ccc2Cl)CC1 by removing a amide.,O=C(Cc1ccccc1O)N1CCN(S(=O)(=O)c2cc(Cl)ccc2Cl)CC1,amide
213485,Remove a amide from the molecule Cc1noc(C(C)C)c1C(=O)N1CCC[C@H]([NH+]2CCCC2)C1.,Cc1noc(C(C)C)c1C(=O)N1CCC[C@H]([NH+]2CCCC2)C1,amide
198929,Remove a benzene_ring from the molecule Cn1ccnc1[C@@H](NC(=O)[C@H]1CCCN(C(=O)Nc2ccccc2)C1)c1ccc(F)cc1.,Cn1ccnc1[C@@H](NC(=O)[C@H]1CCCN(C(=O)Nc2ccccc2)C1)c1ccc(F)cc1,benzene_ring
9923,Modify the molecule C[NH+](C)Cc1cccc(C[NH2+]Cc2ccn(-c3ccccc3)n2)c1 by removing a benzene_ring.,C[NH+](C)Cc1cccc(C[NH2+]Cc2ccn(-c3ccccc3)n2)c1,benzene_ring
225313,Please remove a hydroxyl from the molecule O=C(NCCC1=CCCCC1)NC[C@@H]1CCC[C@H](O)C1.,O=C(NCCC1=CCCCC1)NC[C@@H]1CCC[C@H](O)C1,hydroxyl
188221,Modify the molecule Cc1ccc(O[C@@H](C)C(=O)NCC2(N3CCOCC3)CCCCC2)cc1 by removing a amide.,Cc1ccc(O[C@@H](C)C(=O)NCC2(N3CCOCC3)CCCCC2)cc1,amide
186611,Please remove a amide from the molecule CC1(C)CNC(=O)c2nc([C@@H](O)C[NH+]3CCCCCC3)[nH]c2C1.,CC1(C)CNC(=O)c2nc([C@@H](O)C[NH+]3CCCCCC3)[nH]c2C1,amide
136295,Modify the molecule CC(C)Oc1ccc(CCNC(=O)N[C@@H](C)CO)cc1 by removing a hydroxyl.,CC(C)Oc1ccc(CCNC(=O)N[C@@H](C)CO)cc1,hydroxyl
247908,Please remove a amide from the molecule C=CC[NH2+]CC(=O)N1CCn2cc[nH+]c2C1.,C=CC[NH2+]CC(=O)N1CCn2cc[nH+]c2C1,amide
51524,Remove a benzene_ring from the molecule CCc1ccc(C(=O)[O-])cc1S(=O)(=O)C(CC)CC.,CCc1ccc(C(=O)[O-])cc1S(=O)(=O)C(CC)CC,benzene_ring
96621,Please remove a nitrile from the molecule CC(C)[C@H]1CN(c2cc(C#N)c3ccccc3n2)CCS1.,CC(C)[C@H]1CN(c2cc(C#N)c3ccccc3n2)CCS1,nitrile
97851,Modify the molecule COc1ccc(Cl)cc1NC(=O)CC[S@](=O)Cc1ccc(C)cc1 by removing a amide.,COc1ccc(Cl)cc1NC(=O)CC[S@](=O)Cc1ccc(C)cc1,amide
67638,Remove a amide from the molecule C[NH2+]C[C@H](C)C(=O)N[C@H]1C=C[C@@H](C(=O)[O-])C1.,C[NH2+]C[C@H](C)C(=O)N[C@H]1C=C[C@@H](C(=O)[O-])C1,amide
161196,Please remove a halo from the molecule CC(C)CC[C@@H](C)NC(=O)C(=O)Nc1cccc(F)c1.,CC(C)CC[C@@H](C)NC(=O)C(=O)Nc1cccc(F)c1,halo
155153,Remove a benzene_ring from the molecule CN(CCc1cnccn1)C(=O)Nc1ccc(F)cc1.,CN(CCc1cnccn1)C(=O)Nc1ccc(F)cc1,benzene_ring
22145,Remove a amide from the molecule COc1cccc2c(=O)c(C(=O)Nc3ccc(NC(C)=O)cc3)cn(C)c12.,COc1cccc2c(=O)c(C(=O)Nc3ccc(NC(C)=O)cc3)cn(C)c12,amide
113946,Remove a amide from the molecule O=C(c1ccncc1Cl)N1CCCC[C@@H]1[C@@H]1CCC[NH2+]1.,O=C(c1ccncc1Cl)N1CCCC[C@@H]1[C@@H]1CCC[NH2+]1,amide
18336,Modify the molecule CCn1cnc2sc(C(=O)Nc3ccc(C)c(Cl)c3)c(C)c2c1=O by removing a halo.,CCn1cnc2sc(C(=O)Nc3ccc(C)c(Cl)c3)c(C)c2c1=O,halo
209960,Modify the molecule C[C@H](NC(=O)CO/N=C/C(=O)Nc1ccc(F)cc1)c1ccco1 by removing a amide.,C[C@H](NC(=O)CO/N=C/C(=O)Nc1ccc(F)cc1)c1ccco1,amide
54104,Please remove a amide from the molecule CCOC(=O)c1c(NC(=O)CSc2nc(C)ccc2C#N)sc2c1CCC2.,CCOC(=O)c1c(NC(=O)CSc2nc(C)ccc2C#N)sc2c1CCC2,amide
241335,Modify the molecule COc1cccc(C(=O)Nc2ccn(-c3ccc(C(C)C)cc3)n2)c1 by removing a amide.,COc1cccc(C(=O)Nc2ccn(-c3ccc(C(C)C)cc3)n2)c1,amide
240311,Remove a benzene_ring from the molecule Cc1cccc(C2=CCN(C(=O)NCC[C@@H](C)[S@@](C)=O)CC2)c1.,Cc1cccc(C2=CCN(C(=O)NCC[C@@H](C)[S@@](C)=O)CC2)c1,benzene_ring
213848,Remove a hydroxyl from the molecule CCC[C@H](C[NH3+])C1(O)CCC(c2ccccc2)CC1.,CCC[C@H](C[NH3+])C1(O)CCC(c2ccccc2)CC1,hydroxyl
155319,Please remove a amide from the molecule COc1ccc(C)cc1NC(=O)C(=O)NCc1cc[nH+]c(N(C)C)c1.,COc1ccc(C)cc1NC(=O)C(=O)NCc1cc[nH+]c(N(C)C)c1,amide
212620,Remove a benzene_ring from the molecule COc1ccc(/C=N/NC(=O)c2cc(C)nn2C)c(C(=O)[O-])c1OC.,COc1ccc(/C=N/NC(=O)c2cc(C)nn2C)c(C(=O)[O-])c1OC,benzene_ring
214119,Please remove a hydroxyl from the molecule O=[N+]([O-])c1cc(Br)c(O)c(Cc2ccccc2)c1.,O=[N+]([O-])c1cc(Br)c(O)c(Cc2ccccc2)c1,hydroxyl
85421,Modify the molecule N#CCc1ccc(S(=O)(=O)N[C@@H]2C[C@@H]2c2ccccc2F)cc1 by removing a halo.,N#CCc1ccc(S(=O)(=O)N[C@@H]2C[C@@H]2c2ccccc2F)cc1,halo
196119,Remove a amide from the molecule Cc1nn(CC(=O)N2CCC[C@@H](C)C2)c(=O)c2ccccc12.,Cc1nn(CC(=O)N2CCC[C@@H](C)C2)c(=O)c2ccccc12,amide
215202,Remove a halo from the molecule CCn1cc[nH+]c1C[C@H](O)c1cc(Cl)c2c(c1)OCO2.,CCn1cc[nH+]c1C[C@H](O)c1cc(Cl)c2c(c1)OCO2,halo
37257,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)N(CC(=O)N2CCn3cccc3[C@@H]2c2ccc(Cl)cc2)C(C)(C)C)cc1.,Cc1ccc(C(=O)N(CC(=O)N2CCn3cccc3[C@@H]2c2ccc(Cl)cc2)C(C)(C)C)cc1,benzene_ring
174796,Modify the molecule O=C(CC1(n2cccc2)CCCCC1)NCCO by removing a hydroxyl.,O=C(CC1(n2cccc2)CCCCC1)NCCO,hydroxyl
64577,Remove a amide from the molecule Cc1cc(C(=O)N2CCCC[C@@H]2CCn2cc[nH+]c2)c(C)o1.,Cc1cc(C(=O)N2CCCC[C@@H]2CCn2cc[nH+]c2)c(C)o1,amide
48000,Please remove a amide from the molecule COC(=O)c1sc(NC(=O)c2c[nH]c(=O)cc2C)nc1C1CC1.,COC(=O)c1sc(NC(=O)c2c[nH]c(=O)cc2C)nc1C1CC1,amide
203332,Remove a amide from the molecule O=C([C@H]1CCCC[NH+]1Cc1cccc([N+](=O)[O-])c1)N1CCOCC1.,O=C([C@H]1CCCC[NH+]1Cc1cccc([N+](=O)[O-])c1)N1CCOCC1,amide
74206,Please remove a benzene_ring from the molecule O=C(Nc1ccc2c(c1)nc1n2CCN(c2ccccc2)C1)c1cccc(Br)c1.,O=C(Nc1ccc2c(c1)nc1n2CCN(c2ccccc2)C1)c1cccc(Br)c1,benzene_ring
226239,Modify the molecule Cc1cccc(OC[C@@H](C)NC(=O)CNC(=O)c2ccoc2C)c1 by removing a benzene_ring.,Cc1cccc(OC[C@@H](C)NC(=O)CNC(=O)c2ccoc2C)c1,benzene_ring
188704,Modify the molecule C[C@H](OC(=O)c1ccc(-n2cnnn2)cc1)C(=O)Nc1nc(-c2ccccc2)cs1 by removing a benzene_ring.,C[C@H](OC(=O)c1ccc(-n2cnnn2)cc1)C(=O)Nc1nc(-c2ccccc2)cs1,benzene_ring
172425,Remove a amide from the molecule Cc1nc(-c2cccs2)sc1C(=O)N1c2ccccc2C[C@@H]1C.,Cc1nc(-c2cccs2)sc1C(=O)N1c2ccccc2C[C@@H]1C,amide
215921,Please remove a amine from the molecule O=C(c1ccc(=O)n(Cc2ccccc2)n1)[n+]1ccccc1NC1CCCCC1.,O=C(c1ccc(=O)n(Cc2ccccc2)n1)[n+]1ccccc1NC1CCCCC1,amine
181153,Please remove a hydroxyl from the molecule CCN(CCc1nccs1)Cc1cc(O)ccc1Br.,CCN(CCc1nccs1)Cc1cc(O)ccc1Br,hydroxyl
151402,Remove a halo from the molecule Cc1cc(SCC(=O)Nc2ccc(Br)cc2)nc2ccc(S(=O)(=O)N(C)C)cc12.,Cc1cc(SCC(=O)Nc2ccc(Br)cc2)nc2ccc(S(=O)(=O)N(C)C)cc12,halo
105429,Modify the molecule Cc1ccc([C@@H](C)[NH2+][C@@H](C)c2ccc(-n3ccnn3)cc2)cc1F by removing a benzene_ring.,Cc1ccc([C@@H](C)[NH2+][C@@H](C)c2ccc(-n3ccnn3)cc2)cc1F,benzene_ring
170485,Remove a amide from the molecule CCCS(=O)(=O)[N-]c1cccc(NC(=O)c2ccccc2OC)c1C.,CCCS(=O)(=O)[N-]c1cccc(NC(=O)c2ccccc2OC)c1C,amide
96649,Modify the molecule COC(=O)c1c(C)cc(C)cc1C by removing a benzene_ring.,COC(=O)c1c(C)cc(C)cc1C,benzene_ring
228947,Remove a benzene_ring from the molecule O=S(=O)(c1ccccc1Cl)N(C[C@@H]1CCCO1)[C@@H]1CCSC1.,O=S(=O)(c1ccccc1Cl)N(C[C@@H]1CCCO1)[C@@H]1CCSC1,benzene_ring
138411,Please remove a halo from the molecule Cc1ccccc1-n1cc(C(=O)N2CCC(OCc3ccc(F)cc3)CC2)cn1.,Cc1ccccc1-n1cc(C(=O)N2CCC(OCc3ccc(F)cc3)CC2)cn1,halo
107363,Remove a halo from the molecule COc1ccc(N2C(=O)C[C@@H]([NH+]3CCC(c4ccc(O)cc4)CC3)C2=O)cc1Cl.,COc1ccc(N2C(=O)C[C@@H]([NH+]3CCC(c4ccc(O)cc4)CC3)C2=O)cc1Cl,halo
46905,Remove a amide from the molecule CC(C)n1ncc2c(C(=O)N[C@H](C)c3ccc(NC(=O)c4ccc(F)cc4)cc3)cc(C3CC3)nc21.,CC(C)n1ncc2c(C(=O)N[C@H](C)c3ccc(NC(=O)c4ccc(F)cc4)cc3)cc(C3CC3)nc21,amide
170756,Remove a benzene_ring from the molecule COc1cc(S(=O)(=O)CCO)cc(C(=O)[O-])c1OC.,COc1cc(S(=O)(=O)CCO)cc(C(=O)[O-])c1OC,benzene_ring
45948,Please remove a halo from the molecule Cc1cc(C(=O)NCc2nnc3n2CC[NH+](Cc2c(F)ccc(F)c2F)CC3)c(C)o1.,Cc1cc(C(=O)NCc2nnc3n2CC[NH+](Cc2c(F)ccc(F)c2F)CC3)c(C)o1,halo
159865,Please remove a benzene_ring from the molecule c1ccc(CCCCc2ccccc2)cc1.,c1ccc(CCCCc2ccccc2)cc1,benzene_ring
150102,Remove a amide from the molecule CO[C@@H](CNC(=O)[C@@H]1CCC(=O)N1)c1ccc(F)cc1.,CO[C@@H](CNC(=O)[C@@H]1CCC(=O)N1)c1ccc(F)cc1,amide
228566,Remove a amide from the molecule Cc1ccc(-n2ccnc2SCC(=O)N2CCC[C@H](C(N)=O)C2)cc1C.,Cc1ccc(-n2ccnc2SCC(=O)N2CCC[C@H](C(N)=O)C2)cc1C,amide
123571,Modify the molecule CNC(=O)CC1CCN(C(=O)c2ccc(F)cc2)CC1 by removing a amide.,CNC(=O)CC1CCN(C(=O)c2ccc(F)cc2)CC1,amide
49624,Modify the molecule Cc1nc(C(C)C)[nH]c(=O)c1C(=O)N(C)CC(=O)[O-] by removing a amide.,Cc1nc(C(C)C)[nH]c(=O)c1C(=O)N(C)CC(=O)[O-],amide
192416,Modify the molecule Cc1cc(-c2ccc(S(=O)(=O)NC3CCCC3)s2)[nH]n1 by removing a amine.,Cc1cc(-c2ccc(S(=O)(=O)NC3CCCC3)s2)[nH]n1,amine
55626,Modify the molecule CSc1ccccc1NC(=O)CSc1ccc(F)cc1N by removing a amine.,CSc1ccccc1NC(=O)CSc1ccc(F)cc1N,amine
189662,Please remove a benzene_ring from the molecule NC(=O)c1ccc(CSCCOc2cccc(F)c2)cc1.,NC(=O)c1ccc(CSCCOc2cccc(F)c2)cc1,benzene_ring
11653,Remove a amide from the molecule O=C(Cc1csc(NC(=O)c2cnccn2)n1)Nc1ccccc1.,O=C(Cc1csc(NC(=O)c2cnccn2)n1)Nc1ccccc1,amide
90796,Remove a benzene_ring from the molecule C[C@H]1CN(C2=NC(=O)/C(=C\c3ccc4noc(-c5ccccc5)c4c3)S2)C[C@@H](C)O1.,C[C@H]1CN(C2=NC(=O)/C(=C\c3ccc4noc(-c5ccccc5)c4c3)S2)C[C@@H](C)O1,benzene_ring
155123,Remove a amide from the molecule COc1cccc(C(=O)NCCc2nc3c(s2)CCCC3)c1OC.,COc1cccc(C(=O)NCCc2nc3c(s2)CCCC3)c1OC,amide
180852,Remove a halo from the molecule CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CCOCC1.,CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CCOCC1,halo
33187,Please remove a amine from the molecule CNS(=O)(=O)c1cccc(C(=O)N(C)Cc2cnn(C)c2)c1.,CNS(=O)(=O)c1cccc(C(=O)N(C)Cc2cnn(C)c2)c1,amine
187415,Please remove a benzene_ring from the molecule Fc1cccc(CN2CCC[C@@H](c3nnc(-c4cccnc4)o3)C2)c1F.,Fc1cccc(CN2CCC[C@@H](c3nnc(-c4cccnc4)o3)C2)c1F,benzene_ring
25860,Remove a amide from the molecule O=C1[C@H](c2ccncc2)N(Cc2ccco2)C(=O)CN1c1ccccc1.,O=C1[C@H](c2ccncc2)N(Cc2ccco2)C(=O)CN1c1ccccc1,amide
143770,Remove a amide from the molecule C/C(=N/NC(=O)CN(c1cccc(Br)c1)S(C)(=O)=O)c1ccc(F)cc1.,C/C(=N/NC(=O)CN(c1cccc(Br)c1)S(C)(=O)=O)c1ccc(F)cc1,amide
224494,Remove a hydroxyl from the molecule C[C@@](O)(CNC(=O)CCn1cc([N+](=O)[O-])cn1)c1ccc(F)cc1.,C[C@@](O)(CNC(=O)CCn1cc([N+](=O)[O-])cn1)c1ccc(F)cc1,hydroxyl
145362,Remove a benzene_ring from the molecule CCc1ccc(-n2c(SCC(=O)c3ccc[nH]3)nnc2-c2ccncc2)cc1.,CCc1ccc(-n2c(SCC(=O)c3ccc[nH]3)nnc2-c2ccncc2)cc1,benzene_ring
30885,Remove a benzene_ring from the molecule CSc1ccc(/C=C(/C)C[NH2+]CC(C)C)cc1.,CSc1ccc(/C=C(/C)C[NH2+]CC(C)C)cc1,benzene_ring
245791,Modify the molecule O=C(Nc1nnc(Cc2ccccc2)s1)[C@@H]1CC(=O)N(Cc2ccccc2)C1 by removing a benzene_ring.,O=C(Nc1nnc(Cc2ccccc2)s1)[C@@H]1CC(=O)N(Cc2ccccc2)C1,benzene_ring
82380,Modify the molecule CCc1cc(I)ccc1NC(=O)c1ccccc1F by removing a halo.,CCc1cc(I)ccc1NC(=O)c1ccccc1F,halo
38213,Remove a halo from the molecule CC[C@H](Nc1nccn2cnnc12)c1ccccc1OC(F)F.,CC[C@H](Nc1nccn2cnnc12)c1ccccc1OC(F)F,halo
117146,Remove a amide from the molecule CC(C)Cn1c(SCC(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)nc2ccccc21.,CC(C)Cn1c(SCC(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)nc2ccccc21,amide
77285,Remove a amide from the molecule Cc1ccccc1-n1ncc2c(O)nc(SCC(=O)N3C[C@H](C)O[C@@H](C)C3)nc21.,Cc1ccccc1-n1ncc2c(O)nc(SCC(=O)N3C[C@H](C)O[C@@H](C)C3)nc21,amide
166130,Modify the molecule Cc1cccc(NC(=O)N[C@@H]2CCCc3c2cnn3Cc2ccccc2)c1C by removing a benzene_ring.,Cc1cccc(NC(=O)N[C@@H]2CCCc3c2cnn3Cc2ccccc2)c1C,benzene_ring
241405,Remove a benzene_ring from the molecule O=[S@]1N/C(=C/c2ccc(Cl)cc2)NO1.,O=[S@]1N/C(=C/c2ccc(Cl)cc2)NO1,benzene_ring
14411,Please remove a benzene_ring from the molecule CC(=O)c1ccc(OC[C@@H](O)CN2CCN(c3ccccc3)CC2)cc1.,CC(=O)c1ccc(OC[C@@H](O)CN2CCN(c3ccccc3)CC2)cc1,benzene_ring
118311,Please remove a amide from the molecule CCOC(=O)N1CCC[C@@H](C(=O)NCC(C)(C)c2ccncc2)C1.,CCOC(=O)N1CCC[C@@H](C(=O)NCC(C)(C)c2ccncc2)C1,amide
112657,Remove a benzene_ring from the molecule COc1ccc(-c2csc(/C(C#N)=C\c3ccc(OCC#N)cc3)n2)cc1.,COc1ccc(-c2csc(/C(C#N)=C\c3ccc(OCC#N)cc3)n2)cc1,benzene_ring
144227,Please remove a amide from the molecule COc1ccc(NC(=O)C(=O)N[C@@H](C)c2cc3ccccc3o2)cn1.,COc1ccc(NC(=O)C(=O)N[C@@H](C)c2cc3ccccc3o2)cn1,amide
83061,Please remove a amide from the molecule Nc1cccc(C(=O)N[C@@H]2C=C[C@@H](C(=O)[O-])C2)c1.,Nc1cccc(C(=O)N[C@@H]2C=C[C@@H](C(=O)[O-])C2)c1,amide
154935,Remove a nitro from the molecule C[C@H]1CN(c2ccc([N+](=O)[O-])cc2F)CC[NH2+]1.,C[C@H]1CN(c2ccc([N+](=O)[O-])cc2F)CC[NH2+]1,nitro
67572,Please remove a hydroxyl from the molecule CC(C)[NH2+]Cc1ccc(S[C@H](C)CCO)c(F)c1.,CC(C)[NH2+]Cc1ccc(S[C@H](C)CCO)c(F)c1,hydroxyl
55703,Remove a amide from the molecule COCCNC(=O)NC(=O)C[NH+]1Cc2ccccc2N(C)C[C@@H]1C.,COCCNC(=O)NC(=O)C[NH+]1Cc2ccccc2N(C)C[C@@H]1C,amide
95423,Please remove a amide from the molecule CC(C)(C)c1ccccc1OCC(=O)NC1CC[NH+]([C@@H]2CCOC2)CC1.,CC(C)(C)c1ccccc1OCC(=O)NC1CC[NH+]([C@@H]2CCOC2)CC1,amide
219953,Modify the molecule NC(=O)CCCNC(=O)C1(c2ccc3c(c2)OCO3)CCCCC1 by removing a amide.,NC(=O)CCCNC(=O)C1(c2ccc3c(c2)OCO3)CCCCC1,amide
18803,Please remove a amide from the molecule COCCNC(=O)Cc1c(C)c2cc3c(C)c(C)oc3c(C)c2oc1=O.,COCCNC(=O)Cc1c(C)c2cc3c(C)c(C)oc3c(C)c2oc1=O,amide
125986,Remove a halo from the molecule Cc1nn(Cc2ccccc2)c(Cl)c1C(=O)NC[C@@H](c1cccs1)N(C)C.,Cc1nn(Cc2ccccc2)c(Cl)c1C(=O)NC[C@@H](c1cccs1)N(C)C,halo
51640,Remove a benzene_ring from the molecule O=CN[C@H]1CCCC[C@@H]1c1ccc([C@H]2CCCC[C@@H]2NC=O)cc1.,O=CN[C@H]1CCCC[C@@H]1c1ccc([C@H]2CCCC[C@@H]2NC=O)cc1,benzene_ring
76112,Please remove a nitrile from the molecule COc1ccc(NC(=O)/C(C#N)=C/c2c(Oc3ccccc3F)nc3ccccn3c2=O)cc1.,COc1ccc(NC(=O)/C(C#N)=C/c2c(Oc3ccccc3F)nc3ccccn3c2=O)cc1,nitrile
187310,Remove a halo from the molecule Cc1cccc2cc(CN(Cc3cccnc3)C(=S)Nc3cccc(Cl)c3)c(=O)[nH]c12.,Cc1cccc2cc(CN(Cc3cccnc3)C(=S)Nc3cccc(Cl)c3)c(=O)[nH]c12,halo
33103,Remove a amine from the molecule c1ccc2c(c1)CC[C@@H](N[C@@H]1CC[NH2+]C1)C2.,c1ccc2c(c1)CC[C@@H](N[C@@H]1CC[NH2+]C1)C2,amine
181264,Please remove a halo from the molecule COc1ccc(C)cc1CCNC(=O)C(=O)Nc1cc(F)ccc1OC.,COc1ccc(C)cc1CCNC(=O)C(=O)Nc1cc(F)ccc1OC,halo
100731,Modify the molecule Cc1cc(N)cc(Cl)c1[NH+]1CCC(C)CC1 by removing a amine.,Cc1cc(N)cc(Cl)c1[NH+]1CCC(C)CC1,amine
48466,Remove a nitro from the molecule O=c1oc2cc([N+](=O)[O-])ccc2n1Cc1noc(-c2cccs2)n1.,O=c1oc2cc([N+](=O)[O-])ccc2n1Cc1noc(-c2cccs2)n1,nitro
181613,Remove a amide from the molecule Cc1cccc(NC(=O)NC(=O)c2ccc3ccccc3c2)c1.,Cc1cccc(NC(=O)NC(=O)c2ccc3ccccc3c2)c1,amide
183109,Please remove a benzene_ring from the molecule CC[C@@H]([NH2+]Cc1cccc(-c2n[nH]c(C)n2)c1)c1ccc2c(c1)OCCO2.,CC[C@@H]([NH2+]Cc1cccc(-c2n[nH]c(C)n2)c1)c1ccc2c(c1)OCCO2,benzene_ring
119420,Please remove a halo from the molecule C[C@H]1C[C@H](N2CCC(O)(C(F)(F)F)CC2)C(=O)O1.,C[C@H]1C[C@H](N2CCC(O)(C(F)(F)F)CC2)C(=O)O1,halo
205431,Please remove a amide from the molecule Cc1noc(C)c1[C@@H](C)NC(=O)c1ccccc1NC(=O)NC(C)C.,Cc1noc(C)c1[C@@H](C)NC(=O)c1ccccc1NC(=O)NC(C)C,amide
159824,Remove a nitro from the molecule O=[N+]([O-])c1ccc2nc(NC3CCC3)oc2c1.,O=[N+]([O-])c1ccc2nc(NC3CCC3)oc2c1,nitro
151431,Remove a amide from the molecule Cc1nc(C2(NC(=O)Cc3csc(-n4c(C)ccc4C)n3)CCCC2)no1.,Cc1nc(C2(NC(=O)Cc3csc(-n4c(C)ccc4C)n3)CCCC2)no1,amide
103432,Modify the molecule CC[NH2+]C[C@@H]1CCCC[NH+]1Cc1ccccc1 by removing a benzene_ring.,CC[NH2+]C[C@@H]1CCCC[NH+]1Cc1ccccc1,benzene_ring
171885,Please remove a hydroxyl from the molecule C[C@@H](Cc1cccs1)[NH+](C)C[C@H](O)c1ccc(N)cc1.,C[C@@H](Cc1cccs1)[NH+](C)C[C@H](O)c1ccc(N)cc1,hydroxyl
78514,Please remove a benzene_ring from the molecule Cc1nccn1-c1ccc(C(=O)/C=C/C2=Cc3ccccc3OC2)cc1.,Cc1nccn1-c1ccc(C(=O)/C=C/C2=Cc3ccccc3OC2)cc1,benzene_ring
122584,Remove a amide from the molecule O=C(Cn1cc([N+](=O)[O-])cn1)N1CCCC1.,O=C(Cn1cc([N+](=O)[O-])cn1)N1CCCC1,amide
125048,Modify the molecule [NH3+]CCOCC(=O)N[C@H](C(=O)[O-])C1CCCCC1 by removing a amide.,[NH3+]CCOCC(=O)N[C@H](C(=O)[O-])C1CCCCC1,amide
157978,Modify the molecule O=C(CSc1nnc(C2CC2)n1C1CC1)N1CCN(Cc2ccccc2)CC1 by removing a benzene_ring.,O=C(CSc1nnc(C2CC2)n1C1CC1)N1CCN(Cc2ccccc2)CC1,benzene_ring
105704,Remove a halo from the molecule FC(F)(F)CCc1noc(COC2CC[NH2+]CC2)n1.,FC(F)(F)CCc1noc(COC2CC[NH2+]CC2)n1,halo
218812,Please remove a nitrile from the molecule C[C@@H](CN1CCOCC1)[NH+]1CCC(Oc2cccc(C#N)c2)CC1.,C[C@@H](CN1CCOCC1)[NH+]1CCC(Oc2cccc(C#N)c2)CC1,nitrile
105136,Remove a benzene_ring from the molecule COc1ccc(OC)c([C@@H](C)NC(=O)Nc2c(F)cccc2F)c1.,COc1ccc(OC)c([C@@H](C)NC(=O)Nc2c(F)cccc2F)c1,benzene_ring
84260,Please remove a amine from the molecule C/C(NC[C@@H]1CCCO1)=C1\C(=O)NC(=O)N(C2CCCCC2)C1=O.,C/C(NC[C@@H]1CCCO1)=C1\C(=O)NC(=O)N(C2CCCCC2)C1=O,amine
20150,Modify the molecule Nc1c(NNC(=O)c2ccc(Cl)cc2Cl)ncnc1NC1CCCCC1 by removing a amine.,Nc1c(NNC(=O)c2ccc(Cl)cc2Cl)ncnc1NC1CCCCC1,amine
228484,Please remove a benzene_ring from the molecule CCc1ccc(NC(=O)[C@H](C)Oc2ccc(OC)cc2)cc1.,CCc1ccc(NC(=O)[C@H](C)Oc2ccc(OC)cc2)cc1,benzene_ring
239722,Modify the molecule COc1ccc(C[C@@H](C)[NH3+])cc1OCc1cccc(C)n1 by removing a benzene_ring.,COc1ccc(C[C@@H](C)[NH3+])cc1OCc1cccc(C)n1,benzene_ring
115818,Please remove a halo from the molecule CCC[NH+]1CCC[C@H]([C@@H](C)NCc2ccc(Br)cc2)C1.,CCC[NH+]1CCC[C@H]([C@@H](C)NCc2ccc(Br)cc2)C1,halo
14020,Modify the molecule CCc1ccc(NC(=O)[C@H](C)[S@@](=O)Cc2nc(C)c(C)s2)cc1 by removing a amide.,CCc1ccc(NC(=O)[C@H](C)[S@@](=O)Cc2nc(C)c(C)s2)cc1,amide
243620,Please remove a amide from the molecule COc1ccccc1[C@H](NC(=O)c1ccn(C)c(=O)c1)c1ccccn1.,COc1ccccc1[C@H](NC(=O)c1ccn(C)c(=O)c1)c1ccccn1,amide
152160,Modify the molecule C[C@H](C#N)Oc1ccc(C[NH+](C)Cc2csc(Br)c2)cc1 by removing a nitrile.,C[C@H](C#N)Oc1ccc(C[NH+](C)Cc2csc(Br)c2)cc1,nitrile
6257,Please remove a benzene_ring from the molecule O=C(CN1CCO[C@@H](c2cccs2)C1)NOCc1ccccc1.,O=C(CN1CCO[C@@H](c2cccs2)C1)NOCc1ccccc1,benzene_ring
201966,Remove a benzene_ring from the molecule CC(=O)NCc1ccc(C(=O)NCc2csc(-c3ccccc3)n2)cc1.,CC(=O)NCc1ccc(C(=O)NCc2csc(-c3ccccc3)n2)cc1,benzene_ring
83531,Modify the molecule COC(=O)C[C@H](NC(=O)c1cccc(N2CCCS2(=O)=O)c1)c1ccc(Br)cc1 by removing a benzene_ring.,COC(=O)C[C@H](NC(=O)c1cccc(N2CCCS2(=O)=O)c1)c1ccc(Br)cc1,benzene_ring
159255,Please remove a amide from the molecule Cc1cc(C)c2sc(N(Cc3ccccc3)C(=O)CC[C@@H]3CCCO3)nc2c1.,Cc1cc(C)c2sc(N(Cc3ccccc3)C(=O)CC[C@@H]3CCCO3)nc2c1,amide
108007,Please remove a halo from the molecule Cc1c(C(=O)N2CCOC[C@@H]2C2CC2)sc2ccc(F)cc12.,Cc1c(C(=O)N2CCOC[C@@H]2C2CC2)sc2ccc(F)cc12,halo
122393,Remove a benzene_ring from the molecule CC[C@H](NC(=O)N1CC=C(c2cccc(C)c2)CC1)c1ccncc1.,CC[C@H](NC(=O)N1CC=C(c2cccc(C)c2)CC1)c1ccncc1,benzene_ring
10174,Modify the molecule CCN(C(=O)C1CC=CC1)c1ccc(F)c(F)c1 by removing a amide.,CCN(C(=O)C1CC=CC1)c1ccc(F)c(F)c1,amide
188926,Modify the molecule COc1ccc(NC(=O)NCCN2C[C@@H](C)O[C@H](C)C2)c([N+](=O)[O-])c1 by removing a nitro.,COc1ccc(NC(=O)NCCN2C[C@@H](C)O[C@H](C)C2)c([N+](=O)[O-])c1,nitro
16277,Remove a amide from the molecule C#CCN(CC(=O)[O-])C(=O)c1nc(CC)n[n-]1.,C#CCN(CC(=O)[O-])C(=O)c1nc(CC)n[n-]1,amide
14552,Remove a amine from the molecule C/[NH+]=C(/NCCN1CCc2sccc2C1)NCc1cccs1.,C/[NH+]=C(/NCCN1CCc2sccc2C1)NCc1cccs1,amine
125781,Please remove a benzene_ring from the molecule CO[C@H](C(=O)N1CCC(n2cc(C(=O)NC3CCCC3)nn2)CC1)c1ccccc1.,CO[C@H](C(=O)N1CCC(n2cc(C(=O)NC3CCCC3)nn2)CC1)c1ccccc1,benzene_ring
38931,Modify the molecule COCCN(CC(F)(F)F)C(=O)[C@H]1C[C@H]1c1ccccc1 by removing a halo.,COCCN(CC(F)(F)F)C(=O)[C@H]1C[C@H]1c1ccccc1,halo
160770,Please remove a amide from the molecule C[C@H]1CSC(SCC(=O)N2CCC(Cc3ccccc3)CC2)=N1.,C[C@H]1CSC(SCC(=O)N2CCC(Cc3ccccc3)CC2)=N1,amide
15574,Please remove a benzene_ring from the molecule O=C(NN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O)c1csc(-c2cccs2)n1.,O=C(NN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O)c1csc(-c2cccs2)n1,benzene_ring
111912,Modify the molecule COc1cccc(/C=C/C(=O)NNC(=O)c2cc(-c3ccccc3)n[nH]2)c1 by removing a amide.,COc1cccc(/C=C/C(=O)NNC(=O)c2cc(-c3ccccc3)n[nH]2)c1,amide
149581,Modify the molecule CCc1n[nH]c(=O)c(CNC(=O)c2ccc(-n3ccnn3)cc2)c1CC by removing a benzene_ring.,CCc1n[nH]c(=O)c(CNC(=O)c2ccc(-n3ccnn3)cc2)c1CC,benzene_ring
244938,Remove a amide from the molecule COc1cccc(CN(C)C(=O)Cn2ncnc2-c2cccc(C#N)c2)c1.,COc1cccc(CN(C)C(=O)Cn2ncnc2-c2cccc(C#N)c2)c1,amide
213262,Please remove a amide from the molecule COc1cccc2sc(NC(=O)[C@H](C)OC)nc12.,COc1cccc2sc(NC(=O)[C@H](C)OC)nc12,amide
93751,Remove a halo from the molecule COc1ccc(C[NH2+]Cc2c(C)nn(Cc3ccccc3Cl)c2Cl)cn1.,COc1ccc(C[NH2+]Cc2c(C)nn(Cc3ccccc3Cl)c2Cl)cn1,halo
184306,Modify the molecule COC(=O)[C@H]1CCN(C(=O)[C@@H](Oc2cccc(Cl)c2)C(C)C)C1 by removing a halo.,COC(=O)[C@H]1CCN(C(=O)[C@@H](Oc2cccc(Cl)c2)C(C)C)C1,halo
187307,Please remove a amide from the molecule CCC(=O)Nc1nc2c(c3c1c(=O)oc1ccccc13)C[C@@H](C)CC2.,CCC(=O)Nc1nc2c(c3c1c(=O)oc1ccccc13)C[C@@H](C)CC2,amide
234480,Remove a amide from the molecule CCc1cnc(CCNC(=O)CO[C@@H]2CCC[C@H](C)C2)s1.,CCc1cnc(CCNC(=O)CO[C@@H]2CCC[C@H](C)C2)s1,amide
186188,Modify the molecule CC[NH2+][C@H](C)[C@@H]1CCCCN1c1ccc(C(N)=O)cn1 by removing a amide.,CC[NH2+][C@H](C)[C@@H]1CCCCN1c1ccc(C(N)=O)cn1,amide
34562,Please remove a benzene_ring from the molecule C[NH2+]Cc1cc(C)n(-c2ccc(OC)cc2)c1C.,C[NH2+]Cc1cc(C)n(-c2ccc(OC)cc2)c1C,benzene_ring
229276,Remove a amide from the molecule CCCN(C(C)C)[C@H](C[NH3+])CC(N)=O.,CCCN(C(C)C)[C@H](C[NH3+])CC(N)=O,amide
31233,Remove a benzene_ring from the molecule N#CCc1ccc(Oc2ccc(F)cc2C=O)cc1.,N#CCc1ccc(Oc2ccc(F)cc2C=O)cc1,benzene_ring
99197,Please remove a amide from the molecule O=C(C[NH+]1CC(c2nc(-c3cccnc3)no2)C1)N1CCCC1.,O=C(C[NH+]1CC(c2nc(-c3cccnc3)no2)C1)N1CCCC1,amide
201740,Remove a benzene_ring from the molecule CCn1c([C@@H](C)[NH2+][C@@H](C)c2cccc(NC(C)=O)c2)nc2ccccc21.,CCn1c([C@@H](C)[NH2+][C@@H](C)c2cccc(NC(C)=O)c2)nc2ccccc21,benzene_ring
803,Please remove a amide from the molecule C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1.,C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1,amide
2151,Remove a benzene_ring from the molecule O=C(CS[C@H]1NN=C(C[C@@H]2CCS(=O)(=O)C2)O1)C1=c2ccccc2=[NH+][C@@H]1c1ccccc1.,O=C(CS[C@H]1NN=C(C[C@@H]2CCS(=O)(=O)C2)O1)C1=c2ccccc2=[NH+][C@@H]1c1ccccc1,benzene_ring
48603,Remove a amine from the molecule Cc1nc(C[C@@H]2CCCN(C(=O)CCc3ccccc3)C2)cc(Nc2ncc(C)s2)n1.,Cc1nc(C[C@@H]2CCCN(C(=O)CCc3ccccc3)C2)cc(Nc2ncc(C)s2)n1,amine
241913,Remove a nitrile from the molecule Cc1cc2c(c(=O)o1)[C@@H](c1ccc(Cl)c(Cl)c1)C(C#N)=C(N)O2.,Cc1cc2c(c(=O)o1)[C@@H](c1ccc(Cl)c(Cl)c1)C(C#N)=C(N)O2,nitrile
67828,Remove a benzene_ring from the molecule O=C(Cc1ccc(S(=O)(=O)N2CCCCC2)s1)Nc1ccc(F)cc1F.,O=C(Cc1ccc(S(=O)(=O)N2CCCCC2)s1)Nc1ccc(F)cc1F,benzene_ring
63575,Please remove a amide from the molecule Cc1cc2oc(Br)c(CC(=O)N3CCOCC3)c2cc1Cl.,Cc1cc2oc(Br)c(CC(=O)N3CCOCC3)c2cc1Cl,amide
135819,Remove a amide from the molecule COc1ccc(-c2ccc(=O)n([C@H](C)C(=O)Nc3nc4ccc(Cl)cc4s3)n2)cc1.,COc1ccc(-c2ccc(=O)n([C@H](C)C(=O)Nc3nc4ccc(Cl)cc4s3)n2)cc1,amide
119186,Please remove a amide from the molecule CC[NH+](CC)C[C@H]1CCN(C(=O)[C@@H]2CN(Cc3ccccc3)CCO2)C1.,CC[NH+](CC)C[C@H]1CCN(C(=O)[C@@H]2CN(Cc3ccccc3)CCO2)C1,amide
109940,Please remove a benzene_ring from the molecule [NH3+]CC(=O)N1CCCC[C@@H]1CNC(=O)OCc1ccccc1.,[NH3+]CC(=O)N1CCCC[C@@H]1CNC(=O)OCc1ccccc1,benzene_ring
123914,Please remove a amide from the molecule CO[C@H]1CCCC[C@H]1NC(=O)c1cnc(C)c(Cl)c1Br.,CO[C@H]1CCCC[C@H]1NC(=O)c1cnc(C)c(Cl)c1Br,amide
208901,Remove a halo from the molecule Cc1cc(C[NH2+]Cc2ccc3c(c2)CCC3)cc(C)c1F.,Cc1cc(C[NH2+]Cc2ccc3c(c2)CCC3)cc(C)c1F,halo
173565,Remove a hydroxyl from the molecule CCCCn1ncc(C(=O)N[C@@H](CO)c2ccco2)c1C.,CCCCn1ncc(C(=O)N[C@@H](CO)c2ccco2)c1C,hydroxyl
139831,Modify the molecule Cc1cc(N)cc(S(=O)(=O)Nc2cc(C)ccc2F)c1 by removing a benzene_ring.,Cc1cc(N)cc(S(=O)(=O)Nc2cc(C)ccc2F)c1,benzene_ring
140904,Modify the molecule CC(=O)Nc1ccccc1C[NH+]1CC[C@H](c2ccccc2)[C@@H](C)C1 by removing a amide.,CC(=O)Nc1ccccc1C[NH+]1CC[C@H](c2ccccc2)[C@@H](C)C1,amide
126478,Remove a halo from the molecule O=C(CCC(=O)c1ccc(F)cc1)OCc1cc2c(cc1Br)OCCO2.,O=C(CCC(=O)c1ccc(F)cc1)OCc1cc2c(cc1Br)OCCO2,halo
79958,Modify the molecule COc1ccccc1C[C@@H](C)N(C)C(=O)N[C@@H]1CCC[C@H](SC)C1 by removing a benzene_ring.,COc1ccccc1C[C@@H](C)N(C)C(=O)N[C@@H]1CCC[C@H](SC)C1,benzene_ring
33905,Please remove a amide from the molecule CCOc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)c(C)c2)cc1.,CCOc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)c(C)c2)cc1,amide
215467,Remove a halo from the molecule Cc1cc(NC(=O)[C@@]2(C)Oc3ccc(Cl)cc3NC2=O)no1.,Cc1cc(NC(=O)[C@@]2(C)Oc3ccc(Cl)cc3NC2=O)no1,halo
102351,Remove a amide from the molecule COC(=O)C[C@H]1CCCCN1C(=O)c1nc2nccc(C)n2n1.,COC(=O)C[C@H]1CCCCN1C(=O)c1nc2nccc(C)n2n1,amide
120800,Remove a benzene_ring from the molecule CC(=O)Nc1ccc(C[NH+]2CCC(C3CCOCC3)CC2)cc1.,CC(=O)Nc1ccc(C[NH+]2CCC(C3CCOCC3)CC2)cc1,benzene_ring
132235,Remove a amide from the molecule Cc1cc(C(=O)N2CCN(Cc3ccc([C@@H]4C[C@@H]4C)o3)CC2)on1.,Cc1cc(C(=O)N2CCN(Cc3ccc([C@@H]4C[C@@H]4C)o3)CC2)on1,amide
63115,Remove a benzene_ring from the molecule O=C(NNc1ccc(F)cc1)Nc1ccc(C(=O)Nc2ccccc2)cc1.,O=C(NNc1ccc(F)cc1)Nc1ccc(C(=O)Nc2ccccc2)cc1,benzene_ring
144693,Modify the molecule COc1ccc([C@@H]2CCCN2C(=O)COc2cc(C)ccc2F)cc1 by removing a benzene_ring.,COc1ccc([C@@H]2CCCN2C(=O)COc2cc(C)ccc2F)cc1,benzene_ring
248359,Please remove a halo from the molecule Cc1cccc(N2C(=O)CSC23CCN(C(=O)CCl)CC3)c1.,Cc1cccc(N2C(=O)CSC23CCN(C(=O)CCl)CC3)c1,halo
167259,Remove a halo from the molecule CCn1nc(C)c(Cl)c1C[C@H](C[NH3+])c1ccccc1Br.,CCn1nc(C)c(Cl)c1C[C@H](C[NH3+])c1ccccc1Br,halo
108031,Remove a amine from the molecule CC1CC[NH+](CCCNCc2cn(C)nc2C(C)(C)C)CC1.,CC1CC[NH+](CCCNCc2cn(C)nc2C(C)(C)C)CC1,amine
212278,Modify the molecule Cc1ccccc1Nc1nc(CSc2nnc(C)n2C2CC2)cs1 by removing a benzene_ring.,Cc1ccccc1Nc1nc(CSc2nnc(C)n2C2CC2)cs1,benzene_ring
106004,Modify the molecule CC(C)[NH+]1CC[C@H](NS(=O)(=O)c2cccc(C(F)(F)F)c2)C1 by removing a amine.,CC(C)[NH+]1CC[C@H](NS(=O)(=O)c2cccc(C(F)(F)F)c2)C1,amine
222728,Remove a amide from the molecule C[C@@H]1CCCCN1C(=O)[C@@H](C)n1nc(-c2ccccc2)ccc1=O.,C[C@@H]1CCCCN1C(=O)[C@@H](C)n1nc(-c2ccccc2)ccc1=O,amide
7249,Modify the molecule CCOc1ccccc1NC(=O)COC(=O)c1c2c(nc3ccccc13)CC[C@@H](C)C2 by removing a benzene_ring.,CCOc1ccccc1NC(=O)COC(=O)c1c2c(nc3ccccc13)CC[C@@H](C)C2,benzene_ring
53004,Remove a amide from the molecule CCS(=O)(=O)CCN(C)C(=O)CC[C@@H]1CCCOC1.,CCS(=O)(=O)CCN(C)C(=O)CC[C@@H]1CCCOC1,amide
160577,Please remove a benzene_ring from the molecule CCOC(=O)c1ccc(N/C([O-])=C(\C#N)C(=O)c2ccc(C)c(C)c2)cc1.,CCOC(=O)c1ccc(N/C([O-])=C(\C#N)C(=O)c2ccc(C)c(C)c2)cc1,benzene_ring
74786,Remove a amide from the molecule Cc1ccc(N2CCN(C(=O)CCc3cc([O-])no3)CC2=O)cc1.,Cc1ccc(N2CCN(C(=O)CCc3cc([O-])no3)CC2=O)cc1,amide
233074,Remove a benzene_ring from the molecule O=c1cc(CS(=O)(=O)c2ccccc2)nc2ccccn12.,O=c1cc(CS(=O)(=O)c2ccccc2)nc2ccccn12,benzene_ring
49131,Modify the molecule CC(C)CC(=O)Nc1cccc(CNC(=O)Nc2ccccc2N(C)C)c1 by removing a benzene_ring.,CC(C)CC(=O)Nc1cccc(CNC(=O)Nc2ccccc2N(C)C)c1,benzene_ring
218923,Remove a halo from the molecule CN(C)C(=O)[C@@H](c1ccccc1)n1nnc(-c2ccc(F)cc2)n1.,CN(C)C(=O)[C@@H](c1ccccc1)n1nnc(-c2ccc(F)cc2)n1,halo
246717,Please remove a benzene_ring from the molecule CC(C)Oc1ccc(CNC(=O)Nc2ccccc2OC(C)C)cn1.,CC(C)Oc1ccc(CNC(=O)Nc2ccccc2OC(C)C)cn1,benzene_ring
242970,Please remove a amide from the molecule O=C(C1CC1)N1CCc2ccc(NS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cc2C1.,O=C(C1CC1)N1CCc2ccc(NS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cc2C1,amide
34155,Please remove a benzene_ring from the molecule CN(CCOc1ccc(F)cc1Cl)S(=O)(=O)c1ccc(Cl)nc1.,CN(CCOc1ccc(F)cc1Cl)S(=O)(=O)c1ccc(Cl)nc1,benzene_ring
145100,Remove a halo from the molecule CCOc1ccc2c(c1)s/c(=N\C(=O)c1ccccc1F)n2CCOC.,CCOc1ccc2c(c1)s/c(=N\C(=O)c1ccccc1F)n2CCOC,halo
5203,Please remove a nitrile from the molecule CC(=O)Oc1ccc(/C=C(\C#N)C(=O)Nc2ccc([N+](=O)[O-])cc2Cl)cc1Br.,CC(=O)Oc1ccc(/C=C(\C#N)C(=O)Nc2ccc([N+](=O)[O-])cc2Cl)cc1Br,nitrile
172623,Please remove a amide from the molecule CCC[C@H](C)NC(=O)[C@@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1.,CCC[C@H](C)NC(=O)[C@@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1,amide
29833,Please remove a amine from the molecule CC[C@H](C)N/C(NCc1cccc([N+]2=CCCC2)c1)=[NH+]\C.,CC[C@H](C)N/C(NCc1cccc([N+]2=CCCC2)c1)=[NH+]\C,amine
108859,Remove a amide from the molecule COc1ccc(NC(=O)/C=C/c2ccccc2[N+](=O)[O-])c2cccnc12.,COc1ccc(NC(=O)/C=C/c2ccccc2[N+](=O)[O-])c2cccnc12,amide
146758,Please remove a halo from the molecule CN(C)c1cc(C(=O)Nc2cccc(Cl)c2Cl)ccn1.,CN(C)c1cc(C(=O)Nc2cccc(Cl)c2Cl)ccn1,halo
240393,Please remove a benzene_ring from the molecule CCCc1ccc(-c2nc(NC(=O)Cc3c(C)[nH]c4ccnn4c3=O)sc2C)cc1.,CCCc1ccc(-c2nc(NC(=O)Cc3c(C)[nH]c4ccnn4c3=O)sc2C)cc1,benzene_ring
16741,Remove a benzene_ring from the molecule COc1ccc(CC(=O)NNC(=O)c2oc3ccccc3c2C)cc1OC.,COc1ccc(CC(=O)NNC(=O)c2oc3ccccc3c2C)cc1OC,benzene_ring
116395,Please remove a amide from the molecule COc1cc(NC(=O)c2cc(-c3cccc(OC)c3)n[nH]2)cc(OC)c1.,COc1cc(NC(=O)c2cc(-c3cccc(OC)c3)n[nH]2)cc(OC)c1,amide
164111,Please remove a benzene_ring from the molecule CCOc1ccc(-c2cc(O)cc(C(F)(F)F)c2)c(C)c1.,CCOc1ccc(-c2cc(O)cc(C(F)(F)F)c2)c(C)c1,benzene_ring
94738,Remove a amide from the molecule O=C([C@H]1Cc2[nH+]c[nH]c2CN1)N1CCC[NH+]2CCC[C@@H]2C1.,O=C([C@H]1Cc2[nH+]c[nH]c2CN1)N1CCC[NH+]2CCC[C@@H]2C1,amide
194085,Remove a benzene_ring from the molecule CN(C1CC1)[C@@H](c1ccccc1)[C@H]([NH3+])Cc1ccccc1.,CN(C1CC1)[C@@H](c1ccccc1)[C@H]([NH3+])Cc1ccccc1,benzene_ring
195910,Modify the molecule Cc1nc(C)n(-c2ccccc2NC(=O)N(C)C[C@H](C)c2ccccc2)n1 by removing a benzene_ring.,Cc1nc(C)n(-c2ccccc2NC(=O)N(C)C[C@H](C)c2ccccc2)n1,benzene_ring
123651,Modify the molecule C[C@@H](NC(=O)c1cccc(Oc2cnccn2)c1)c1ccncc1 by removing a benzene_ring.,C[C@@H](NC(=O)c1cccc(Oc2cnccn2)c1)c1ccncc1,benzene_ring
123258,Please remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)c1csc2c1CCCC2.,Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)c1csc2c1CCCC2,benzene_ring
215388,Modify the molecule Cc1cc(C)cc(NC(=O)Cc2nc(C)c(C(=O)NCC(C)C)s2)c1 by removing a amide.,Cc1cc(C)cc(NC(=O)Cc2nc(C)c(C(=O)NCC(C)C)s2)c1,amide
66335,Please remove a amide from the molecule CC(C)N(C(=O)CSc1cccc[n+]1[O-])c1ccccc1.,CC(C)N(C(=O)CSc1cccc[n+]1[O-])c1ccccc1,amide
198604,Remove a halo from the molecule NC(=O)[C@@H]1CCC[C@@H]1NC(=O)NCC1(c2cccc(F)c2)CC1.,NC(=O)[C@@H]1CCC[C@@H]1NC(=O)NCC1(c2cccc(F)c2)CC1,halo
55821,Please remove a benzene_ring from the molecule Oc1cc2c(cc1C[NH+]1CCN(c3cccc(C(F)(F)F)c3)CC1)CCC2.,Oc1cc2c(cc1C[NH+]1CCN(c3cccc(C(F)(F)F)c3)CC1)CCC2,benzene_ring
245876,Remove a benzene_ring from the molecule Cc1n[nH]c2ncc(NC(=O)NC[C@@H](C)COCc3ccccc3)cc12.,Cc1n[nH]c2ncc(NC(=O)NC[C@@H](C)COCc3ccccc3)cc12,benzene_ring
23265,Please remove a amide from the molecule CCCCN(C(=O)C[NH+](C)[C@@H]1CCC[C@H](C)C1)[C@H]1CCS(=O)(=O)C1.,CCCCN(C(=O)C[NH+](C)[C@@H]1CCC[C@H](C)C1)[C@H]1CCS(=O)(=O)C1,amide
7308,Modify the molecule CC(C)C[C@@H](NC(=O)NC(C)C)C(=O)N1CCc2nnc(-c3ccccn3)n2CC1 by removing a amide.,CC(C)C[C@@H](NC(=O)NC(C)C)C(=O)N1CCc2nnc(-c3ccccn3)n2CC1,amide
228095,Modify the molecule Cc1ccc([N-]S(=O)(=O)c2c(C)noc2C)cc1NC(=O)c1ccncc1 by removing a amide.,Cc1ccc([N-]S(=O)(=O)c2c(C)noc2C)cc1NC(=O)c1ccncc1,amide
54007,Remove a halo from the molecule C[C@H]1c2ccsc2CCN1C(=O)c1cccc(S(=O)(=O)N(C)c2cccc(Cl)c2)c1.,C[C@H]1c2ccsc2CCN1C(=O)c1cccc(S(=O)(=O)N(C)c2cccc(Cl)c2)c1,halo
107350,Remove a amide from the molecule Cc1cc(NC(=O)CCc2ncc(-c3c(F)cccc3F)o2)[nH]n1.,Cc1cc(NC(=O)CCc2ncc(-c3c(F)cccc3F)o2)[nH]n1,amide
176579,Remove a benzene_ring from the molecule CCOc1cc(N2CCN(C(=O)Nc3cccc(F)c3)CC2)nc(C)n1.,CCOc1cc(N2CCN(C(=O)Nc3cccc(F)c3)CC2)nc(C)n1,benzene_ring
239927,Modify the molecule O=C(Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H]1CCSc2ccc(F)cc21 by removing a halo.,O=C(Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H]1CCSc2ccc(F)cc21,halo
9751,Modify the molecule COc1ccccc1NC(=O)C12C[C@@H]3C[C@H](C1)CC(n1cncn1)(C3)C2 by removing a amide.,COc1ccccc1NC(=O)C12C[C@@H]3C[C@H](C1)CC(n1cncn1)(C3)C2,amide
215625,Please remove a benzene_ring from the molecule COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN(C(=O)N2CCCC2)C1.,COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN(C(=O)N2CCCC2)C1,benzene_ring
223304,Please remove a benzene_ring from the molecule COc1cccc(C(=O)CN2CC[NH+]3CCC[C@@H]3C2)c1.,COc1cccc(C(=O)CN2CC[NH+]3CCC[C@@H]3C2)c1,benzene_ring
140388,Remove a benzene_ring from the molecule Cc1ccc([C@H](O)Cc2nc3ccccc3n2C)c(C)c1.,Cc1ccc([C@H](O)Cc2nc3ccccc3n2C)c(C)c1,benzene_ring
75689,Modify the molecule Nc1cc[nH+]c(Cn2nnc(-c3ccccc3)n2)c1 by removing a amine.,Nc1cc[nH+]c(Cn2nnc(-c3ccccc3)n2)c1,amine
110272,Please remove a benzene_ring from the molecule COc1ccc(-c2cc([C@H]3CCCCC[NH+]3Cc3ccccn3)on2)cc1.,COc1ccc(-c2cc([C@H]3CCCCC[NH+]3Cc3ccccn3)on2)cc1,benzene_ring
42912,Remove a halo from the molecule CC(C)(CSc1ccc(Br)cn1)C(=O)NN.,CC(C)(CSc1ccc(Br)cn1)C(=O)NN,halo
20720,Modify the molecule Cc1ccc(/C=C/C(=O)N2CC[C@H](C(N)=O)c3ccccc32)o1 by removing a amide.,Cc1ccc(/C=C/C(=O)N2CC[C@H](C(N)=O)c3ccccc32)o1,amide
33168,Modify the molecule CC[C@H](CCO)Nc1ccc2cc(Br)ccc2n1 by removing a amine.,CC[C@H](CCO)Nc1ccc2cc(Br)ccc2n1,amine
231771,Modify the molecule O=C(C1CC1)N1CCC(C(=O)N2CCOc3ccc(CO)cc3C2)CC1 by removing a amide.,O=C(C1CC1)N1CCC(C(=O)N2CCOc3ccc(CO)cc3C2)CC1,amide
168845,Remove a benzene_ring from the molecule Cc1ccncc1NC(=O)NCC[C@H](C)c1ccccc1.,Cc1ccncc1NC(=O)NCC[C@H](C)c1ccccc1,benzene_ring
147016,Please remove a amide from the molecule COC(=O)c1c(CC(=O)Nc2ccccn2)[nH]c(C(C)=O)c1C.,COC(=O)c1c(CC(=O)Nc2ccccn2)[nH]c(C(C)=O)c1C,amide
6484,Modify the molecule Cc1ccc(Oc2ccc(NC(=O)C(=O)NCc3ccnn3C)cn2)cc1C by removing a benzene_ring.,Cc1ccc(Oc2ccc(NC(=O)C(=O)NCc3ccnn3C)cn2)cc1C,benzene_ring
29873,Remove a benzene_ring from the molecule CCN(CC)c1ccc(/C=C2/C(=N)N3C(SCc4ccccc4)=NSC3=NC2=O)cc1.,CCN(CC)c1ccc(/C=C2/C(=N)N3C(SCc4ccccc4)=NSC3=NC2=O)cc1,benzene_ring
53106,Modify the molecule Cc1ccc(C(=O)N2CCN(Cc3cc(C#N)cs3)CC2)o1 by removing a amide.,Cc1ccc(C(=O)N2CCN(Cc3cc(C#N)cs3)CC2)o1,amide
31263,Remove a hydroxyl from the molecule Cn1c(C[NH+](C)C[C@H](O)Cn2cccn2)nc2ccccc21.,Cn1c(C[NH+](C)C[C@H](O)Cn2cccn2)nc2ccccc21,hydroxyl
106622,Please remove a hydroxyl from the molecule CC[NH2+]C[C@@H](O)CN1C(=O)CCCC1=O.,CC[NH2+]C[C@@H](O)CN1C(=O)CCCC1=O,hydroxyl
133584,Remove a benzene_ring from the molecule CC[C@@H](C)[C@H](C[NH3+])c1c(Cl)cccc1Cl.,CC[C@@H](C)[C@H](C[NH3+])c1c(Cl)cccc1Cl,benzene_ring
243868,Modify the molecule Cc1cc(C(=O)NCC[NH+]2CCC(c3ccsc3)CC2)ccc1[N+](=O)[O-] by removing a nitro.,Cc1cc(C(=O)NCC[NH+]2CCC(c3ccsc3)CC2)ccc1[N+](=O)[O-],nitro
34400,Please remove a halo from the molecule Cc1ccc(C)c2[nH]c(=O)c(CN(Cc3ccco3)C(=S)Nc3cccc(Cl)c3)cc12.,Cc1ccc(C)c2[nH]c(=O)c(CN(Cc3ccco3)C(=S)Nc3cccc(Cl)c3)cc12,halo
62315,Remove a amine from the molecule CCS(=O)(=O)NCC#CCOc1ccc2c(c1)OCO2.,CCS(=O)(=O)NCC#CCOc1ccc2c(c1)OCO2,amine
244661,Remove a amide from the molecule C[NH+](C)Cc1cccc(CNC(=O)c2n[nH]c(C3CC3)c2Cl)c1.,C[NH+](C)Cc1cccc(CNC(=O)c2n[nH]c(C3CC3)c2Cl)c1,amide
54900,Modify the molecule COc1ccc(Cl)cc1/N=C(/[S-])Nc1ccccc1C by removing a halo.,COc1ccc(Cl)cc1/N=C(/[S-])Nc1ccccc1C,halo
213230,Please remove a amine from the molecule COc1cccc(N2C(=O)[C@@H]3C(C(=O)C(c4ccccc4)c4ccccc4)=NN[C@H]3C2=O)c1.,COc1cccc(N2C(=O)[C@@H]3C(C(=O)C(c4ccccc4)c4ccccc4)=NN[C@H]3C2=O)c1,amine
136675,Modify the molecule C[C@H](CCCO)NC(=O)Nc1cccc(Oc2ccncc2)c1 by removing a hydroxyl.,C[C@H](CCCO)NC(=O)Nc1cccc(Oc2ccncc2)c1,hydroxyl
70978,Remove a hydroxyl from the molecule CCC(=O)Nc1ccc(Cl)c(NC(=O)CCCO)c1.,CCC(=O)Nc1ccc(Cl)c(NC(=O)CCCO)c1,hydroxyl
21172,Please remove a halo from the molecule [NH3+][C@H](Cc1ccc(Cl)cc1)c1c(F)cc(Br)cc1F.,[NH3+][C@H](Cc1ccc(Cl)cc1)c1c(F)cc(Br)cc1F,halo
137845,Remove a halo from the molecule CCc1cccnc1NC(=O)c1cnc2ccc(F)cc2c1.,CCc1cccnc1NC(=O)c1cnc2ccc(F)cc2c1,halo
114605,Modify the molecule CCOC(=O)c1ccccc1NC(=O)[C@H]1C[C@@H]1c1ccccc1 by removing a benzene_ring.,CCOC(=O)c1ccccc1NC(=O)[C@H]1C[C@@H]1c1ccccc1,benzene_ring
46766,Remove a amine from the molecule Nn1c(SCC(=O)N2CCCCC2)nnc1-c1ccc(F)cc1.,Nn1c(SCC(=O)N2CCCCC2)nnc1-c1ccc(F)cc1,amine
247326,Remove a benzene_ring from the molecule COc1cccc(C(=O)[C@H]2CCCN(C(=O)c3cccc(C#CC(C)(C)O)c3)C2)c1.,COc1cccc(C(=O)[C@H]2CCCN(C(=O)c3cccc(C#CC(C)(C)O)c3)C2)c1,benzene_ring
179923,Remove a benzene_ring from the molecule Cc1ccc([N+](=O)[O-])c(CCl)c1.,Cc1ccc([N+](=O)[O-])c(CCl)c1,benzene_ring
174515,Remove a amide from the molecule O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1cc(C(=O)[O-])ccc1Cl.,O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1cc(C(=O)[O-])ccc1Cl,amide
26967,Modify the molecule O=C(Cc1ccccc1)Nc1cccc(C(=O)Nc2ccccc2C(=O)[O-])c1 by removing a benzene_ring.,O=C(Cc1ccccc1)Nc1cccc(C(=O)Nc2ccccc2C(=O)[O-])c1,benzene_ring
60293,Please remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N2CC=CC2)cc1.,Cc1ccc(S(=O)(=O)N2CC=CC2)cc1,benzene_ring
148725,Remove a amide from the molecule CC(C)CC1=C[C@@H](CN2CCN3NC(C(=O)NC4CC4)=C[C@@H]3C2)N=N1.,CC(C)CC1=C[C@@H](CN2CCN3NC(C(=O)NC4CC4)=C[C@@H]3C2)N=N1,amide
220138,Modify the molecule CCn1nc(C)cc1CNc1ccn(C)n1 by removing a amine.,CCn1nc(C)cc1CNc1ccn(C)n1,amine
33904,Please remove a benzene_ring from the molecule O=C(c1ccc(F)cc1F)N(CC(F)(F)F)c1ccccn1.,O=C(c1ccc(F)cc1F)N(CC(F)(F)F)c1ccccn1,benzene_ring
119064,Please remove a amide from the molecule C=C(Nc1ccc(C(C)C)cc1)[C@H]1C(=O)NC(=O)N(CCCC)C1=O.,C=C(Nc1ccc(C(C)C)cc1)[C@H]1C(=O)NC(=O)N(CCCC)C1=O,amide
108370,Modify the molecule CC(=O)c1c(C)[nH]c(C(=O)N2C[C@@H](C)Oc3ccc(C)cc32)c1C by removing a amide.,CC(=O)c1c(C)[nH]c(C(=O)N2C[C@@H](C)Oc3ccc(C)cc32)c1C,amide
136564,Please remove a amine from the molecule CC[C@@H](C(=O)OCC(=O)c1c(N)n(C)c(=O)n(C)c1=O)c1ccccc1.,CC[C@@H](C(=O)OCC(=O)c1c(N)n(C)c(=O)n(C)c1=O)c1ccccc1,amine
64591,Remove a benzene_ring from the molecule CCn1cc(C[NH+]2CCCC[C@H]2c2nc(N(C)C)ncc2-c2ccc(F)cc2)c(C)n1.,CCn1cc(C[NH+]2CCCC[C@H]2c2nc(N(C)C)ncc2-c2ccc(F)cc2)c(C)n1,benzene_ring
141605,Remove a benzene_ring from the molecule Cc1ccc(NC(=O)CC[NH2+][C@@H]2CCN(C3CC3)C2)c(Cl)c1.,Cc1ccc(NC(=O)CC[NH2+][C@@H]2CCN(C3CC3)C2)c(Cl)c1,benzene_ring
161414,Modify the molecule CCNC(=O)c1ccc(CNC(=O)c2oc3c(Cl)cccc3c2C)cc1 by removing a amide.,CCNC(=O)c1ccc(CNC(=O)c2oc3c(Cl)cccc3c2C)cc1,amide
53853,Modify the molecule CC(C)Oc1ccc(NC(=O)C(=O)N[C@H](C)c2cccc(Cl)c2)cc1 by removing a amide.,CC(C)Oc1ccc(NC(=O)C(=O)N[C@H](C)c2cccc(Cl)c2)cc1,amide
53154,Please remove a amide from the molecule Cc1cc(NC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)ncc1Br.,Cc1cc(NC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)ncc1Br,amide
197434,Modify the molecule COC(OC)C12c3ccccc3C(c3ccccc31)[C@H]1C(=O)N(c3cccc(C(F)(F)F)c3)C(=O)[C@@H]12 by removing a halo.,COC(OC)C12c3ccccc3C(c3ccccc31)[C@H]1C(=O)N(c3cccc(C(F)(F)F)c3)C(=O)[C@@H]12,halo
103210,Remove a benzene_ring from the molecule Cc1nn2ncc(C(=O)NCCc3ccc(OCc4ccccc4)cc3)c2[nH]1.,Cc1nn2ncc(C(=O)NCCc3ccc(OCc4ccccc4)cc3)c2[nH]1,benzene_ring
120170,Remove a benzene_ring from the molecule c1ccc(Cn2nnnc2[C@@H](c2ccccc2)N2CC[NH+](Cc3ccncc3)CC2)cc1.,c1ccc(Cn2nnnc2[C@@H](c2ccccc2)N2CC[NH+](Cc3ccncc3)CC2)cc1,benzene_ring
27690,Remove a nitro from the molecule O=[N+]([O-])c1ccc(-c2cc[nH]n2)cc1CS(=O)(=O)c1ccccc1.,O=[N+]([O-])c1ccc(-c2cc[nH]n2)cc1CS(=O)(=O)c1ccccc1,nitro
63128,Modify the molecule COc1ccccc1[C@@H]1CN(C(=O)c2cccs2)C[C@H]1C(=O)N1CCOCC1 by removing a benzene_ring.,COc1ccccc1[C@@H]1CN(C(=O)c2cccs2)C[C@H]1C(=O)N1CCOCC1,benzene_ring
177815,Modify the molecule CCC(=O)N1CCN(C(=O)NCc2cn3c(C)cccc3[nH+]2)CC1 by removing a amide.,CCC(=O)N1CCN(C(=O)NCc2cn3c(C)cccc3[nH+]2)CC1,amide
237916,Remove a benzene_ring from the molecule CCOC(=O)[C@H](C)Sc1ccc(N)c(C)c1.,CCOC(=O)[C@H](C)Sc1ccc(N)c(C)c1,benzene_ring
197840,Modify the molecule COc1cccc2c(C)c(C(=O)N[C@@H]3c4ccccc4C[C@@H]3O)oc12 by removing a amide.,COc1cccc2c(C)c(C(=O)N[C@@H]3c4ccccc4C[C@@H]3O)oc12,amide
116688,Remove a benzene_ring from the molecule CCC[C@H](NC(=O)Nc1cnn(CC(N)=O)c1)c1ccccc1.,CCC[C@H](NC(=O)Nc1cnn(CC(N)=O)c1)c1ccccc1,benzene_ring
241653,Modify the molecule NC(=S)c1c(F)cccc1-n1cnc2ccccc21 by removing a amine.,NC(=S)c1c(F)cccc1-n1cnc2ccccc21,amine
218284,Modify the molecule CCOc1ccccc1-c1cccc(C(=O)N(C)C[C@@H]2CC[NH+](C)C2)c1 by removing a amide.,CCOc1ccccc1-c1cccc(C(=O)N(C)C[C@@H]2CC[NH+](C)C2)c1,amide
230672,Remove a benzene_ring from the molecule CCc1nsc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)n1.,CCc1nsc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)n1,benzene_ring
146966,Remove a benzene_ring from the molecule COc1ccc(NS(=O)(=O)c2cccc3nonc23)cc1Cl.,COc1ccc(NS(=O)(=O)c2cccc3nonc23)cc1Cl,benzene_ring
35644,Modify the molecule Cc1ocnc1CNC(=O)N[C@@H]1CCCN(c2ccccc2F)C1 by removing a benzene_ring.,Cc1ocnc1CNC(=O)N[C@@H]1CCCN(c2ccccc2F)C1,benzene_ring
168579,Please remove a benzene_ring from the molecule COc1cccc(CNC(=O)COC(=O)c2ccc(C)c(C)c2)c1.,COc1cccc(CNC(=O)COC(=O)c2ccc(C)c(C)c2)c1,benzene_ring
157206,Remove a benzene_ring from the molecule CCCC[C@H]([NH2+]C)c1ccc(OC)cc1.,CCCC[C@H]([NH2+]C)c1ccc(OC)cc1,benzene_ring
205425,Please remove a amide from the molecule O=C(NCc1cccnc1-n1cccn1)[C@@H]1CCCN(C(=O)c2ccco2)C1.,O=C(NCc1cccnc1-n1cccn1)[C@@H]1CCCN(C(=O)c2ccco2)C1,amide
107400,Please remove a benzene_ring from the molecule O=C(C[NH2+]C[C@@H]1COc2ccccc2O1)Nc1ccccc1.,O=C(C[NH2+]C[C@@H]1COc2ccccc2O1)Nc1ccccc1,benzene_ring
73383,Modify the molecule CC[C@](C)([C@@H](NC)c1cccc(F)c1F)[NH+]1CCCCC1 by removing a benzene_ring.,CC[C@](C)([C@@H](NC)c1cccc(F)c1F)[NH+]1CCCCC1,benzene_ring
181051,Remove a amide from the molecule Cc1cscc1C[NH2+]CC(=O)NC1CCCCCC1.,Cc1cscc1C[NH2+]CC(=O)NC1CCCCCC1,amide
21631,Modify the molecule Cc1cccn2c(=O)c(C(=O)N[C@@H](C)C(C)(C)C[NH+](C)C)cnc12 by removing a amide.,Cc1cccn2c(=O)c(C(=O)N[C@@H](C)C(C)(C)C[NH+](C)C)cnc12,amide
103291,Remove a amide from the molecule Cc1cc(C)cc(NC(=O)CNc2ccc(C(=O)NC(C)(C)C)cc2)c1.,Cc1cc(C)cc(NC(=O)CNc2ccc(C(=O)NC(C)(C)C)cc2)c1,amide
225789,Modify the molecule C[C@H]([NH2+]Cc1cnn(C(C)(C)C)c1)c1ccc2c(c1)NC(=O)CO2 by removing a amide.,C[C@H]([NH2+]Cc1cnn(C(C)(C)C)c1)c1ccc2c(c1)NC(=O)CO2,amide
11293,Modify the molecule CSCc1ccc(C(=O)N[C@H]2CCCc3ccccc32)cc1 by removing a amide.,CSCc1ccc(C(=O)N[C@H]2CCCc3ccccc32)cc1,amide
218999,Remove a benzene_ring from the molecule CCO[C@H](C)C(=O)Nc1ccccc1OCC1CC1.,CCO[C@H](C)C(=O)Nc1ccccc1OCC1CC1,benzene_ring
13032,Remove a benzene_ring from the molecule Cn1c(=O)c2c(nc(Cl)n2CC(=O)Nc2ccccc2OC(F)F)n(C)c1=O.,Cn1c(=O)c2c(nc(Cl)n2CC(=O)Nc2ccccc2OC(F)F)n(C)c1=O,benzene_ring
21592,Please remove a amide from the molecule CC(C)(C)c1ccc(C2(C(=O)OC[C@@H]3CCC(=O)N3)CC2)cc1.,CC(C)(C)c1ccc(C2(C(=O)OC[C@@H]3CCC(=O)N3)CC2)cc1,amide
216097,Please remove a benzene_ring from the molecule CC[C@@](C)([C@@H](N)c1c(F)cccc1F)[NH+](C)C.,CC[C@@](C)([C@@H](N)c1c(F)cccc1F)[NH+](C)C,benzene_ring
104911,Remove a benzene_ring from the molecule C/[NH+]=C(/NCc1ccnc(-n2ccnc2)c1)NCc1ccccc1Cl.,C/[NH+]=C(/NCc1ccnc(-n2ccnc2)c1)NCc1ccccc1Cl,benzene_ring
81236,Please remove a halo from the molecule C#CCOc1ccc(F)cc1NC(=O)[C@@H](C)Sc1ccccn1.,C#CCOc1ccc(F)cc1NC(=O)[C@@H](C)Sc1ccccn1,halo
181137,Remove a amide from the molecule COc1ccc([C@@H]2C[C@H](C(F)(F)F)n3nc(C(=O)Nc4ccc(Cl)cc4)cc3N2)cc1.,COc1ccc([C@@H]2C[C@H](C(F)(F)F)n3nc(C(=O)Nc4ccc(Cl)cc4)cc3N2)cc1,amide
103321,Remove a benzene_ring from the molecule CC(=O)C1=C([O-])C(=O)N(Cc2cccnc2)[C@@H]1c1ccc(C(C)C)cc1.,CC(=O)C1=C([O-])C(=O)N(Cc2cccnc2)[C@@H]1c1ccc(C(C)C)cc1,benzene_ring
15808,Please remove a benzene_ring from the molecule CC[C@H](NS(=O)(=O)c1ccccc1)c1nccs1.,CC[C@H](NS(=O)(=O)c1ccccc1)c1nccs1,benzene_ring
206036,Modify the molecule O=C1C[C@@H](c2ccco2)Cc2c1cnn2-c1ccccc1F by removing a benzene_ring.,O=C1C[C@@H](c2ccco2)Cc2c1cnn2-c1ccccc1F,benzene_ring
59983,Remove a benzene_ring from the molecule Cc1cc(C)cc(C(=O)NCCn2nc(-c3ccncc3)ccc2=O)c1.,Cc1cc(C)cc(C(=O)NCCn2nc(-c3ccncc3)ccc2=O)c1,benzene_ring
141538,Remove a amide from the molecule CN(CCC1CC1)C(=O)c1ccc(C(=O)OC(C)(C)C)cc1.,CN(CCC1CC1)C(=O)c1ccc(C(=O)OC(C)(C)C)cc1,amide
87363,Remove a benzene_ring from the molecule CC[C@H](O)[C@@H](C)c1ccc(C(C)C)cc1.,CC[C@H](O)[C@@H](C)c1ccc(C(C)C)cc1,benzene_ring
16486,Remove a amide from the molecule COc1ccc(CNC(=O)Cc2c(C)c3ccc(O)c(O)c3oc2=O)cc1.,COc1ccc(CNC(=O)Cc2c(C)c3ccc(O)c(O)c3oc2=O)cc1,amide
223928,Please remove a amide from the molecule O=C(c1ccccc1)[C@H]1[C@@H]2C(=O)N(c3ccc(Br)cc3)C(=O)[C@@H]2[C@H]2C=CC=CN21.,O=C(c1ccccc1)[C@H]1[C@@H]2C(=O)N(c3ccc(Br)cc3)C(=O)[C@@H]2[C@H]2C=CC=CN21,amide
83173,Modify the molecule Cc1nc2ccc(N[C@@H](C)C[C@H]3CCC[NH2+]3)cc2s1 by removing a amine.,Cc1nc2ccc(N[C@@H](C)C[C@H]3CCC[NH2+]3)cc2s1,amine
87777,Modify the molecule CCOC(=O)Cn1c([C@H]2CC(=O)N(Cc3ccccc3)C2)nc2ccccc21 by removing a amide.,CCOC(=O)Cn1c([C@H]2CC(=O)N(Cc3ccccc3)C2)nc2ccccc21,amide
227752,Please remove a benzene_ring from the molecule CCn1c(SCC(=O)NN)nnc1-c1ccc(C(C)(C)C)cc1.,CCn1c(SCC(=O)NN)nnc1-c1ccc(C(C)(C)C)cc1,benzene_ring
127437,Remove a amine from the molecule C[C@@H]1C[NH+]=C(N2CCN(Cc3cnnn3C)CC2)S1.,C[C@@H]1C[NH+]=C(N2CCN(Cc3cnnn3C)CC2)S1,amine
181697,Remove a amide from the molecule COc1cccc2cc(C(=O)Nc3ccc4c(c3)C(=O)NCC4)c(=O)oc12.,COc1cccc2cc(C(=O)Nc3ccc4c(c3)C(=O)NCC4)c(=O)oc12,amide
98010,Remove a benzene_ring from the molecule C[NH+]1CCC[C@@H](c2cnc(-c3ccccc3Cl)cn2)C1.,C[NH+]1CCC[C@@H](c2cnc(-c3ccccc3Cl)cn2)C1,benzene_ring
2124,Remove a halo from the molecule Cc1cc(C)n(CC(=O)Nc2ccc(F)c(Cl)c2)c(=O)c1-c1nc(-c2ccc3c(c2)OCO3)no1.,Cc1cc(C)n(CC(=O)Nc2ccc(F)c(Cl)c2)c(=O)c1-c1nc(-c2ccc3c(c2)OCO3)no1,halo
154725,Please remove a amide from the molecule CC1(C)C(=O)NC(=O)N1CC(=O)N[C@H]1CCC[C@@H]1Cc1ccccc1.,CC1(C)C(=O)NC(=O)N1CC(=O)N[C@H]1CCC[C@@H]1Cc1ccccc1,amide
156770,Modify the molecule Cc1ccc2nc(SCC(=O)NCCCN3C[C@H](C)O[C@H](C)C3)[nH]c2c1 by removing a amide.,Cc1ccc2nc(SCC(=O)NCCCN3C[C@H](C)O[C@H](C)C3)[nH]c2c1,amide
210047,Please remove a benzene_ring from the molecule CC[C@@H]1CC[C@](C#N)([C@H](O)c2ccc(Br)cc2)C1.,CC[C@@H]1CC[C@](C#N)([C@H](O)c2ccc(Br)cc2)C1,benzene_ring
180748,Modify the molecule COc1ccc2oc(C(=O)NCCc3ccc(F)cc3)c(C)c2c1 by removing a amide.,COc1ccc2oc(C(=O)NCCc3ccc(F)cc3)c(C)c2c1,amide
136362,Please remove a benzene_ring from the molecule CCc1cccc(OCC(=O)Nc2nc(-c3ccccc3)c(C(C)=O)s2)c1.,CCc1cccc(OCC(=O)Nc2nc(-c3ccccc3)c(C(C)=O)s2)c1,benzene_ring
204271,Please remove a benzene_ring from the molecule O=C(NCCOCC(F)(F)F)N[C@@H]1C[C@H]1c1cccc(Cl)c1.,O=C(NCCOCC(F)(F)F)N[C@@H]1C[C@H]1c1cccc(Cl)c1,benzene_ring
217520,Please remove a halo from the molecule Cc1cc(S(=O)(=O)N(C)C)c(C)cc1Br.,Cc1cc(S(=O)(=O)N(C)C)c(C)cc1Br,halo
187372,Please remove a benzene_ring from the molecule CSc1cc(C(=O)O[C@@H](C)C(=O)Nc2c(F)cccc2F)ccc1N.,CSc1cc(C(=O)O[C@@H](C)C(=O)Nc2c(F)cccc2F)ccc1N,benzene_ring
87024,Remove a benzene_ring from the molecule Cc1noc(C)c1NC(=O)N1CCN(Cc2ccccc2)C(C)(C)C1.,Cc1noc(C)c1NC(=O)N1CCN(Cc2ccccc2)C(C)(C)C1,benzene_ring
96288,Remove a benzene_ring from the molecule COc1ccc(-c2nc3n(n2)[C@H](CC(=O)Nc2cccc4ccccc24)C(=O)N3)cc1.,COc1ccc(-c2nc3n(n2)[C@H](CC(=O)Nc2cccc4ccccc24)C(=O)N3)cc1,benzene_ring
112659,Please remove a nitro from the molecule CCc1c([N+](=O)[O-])cc(C(=O)[O-])n1C.,CCc1c([N+](=O)[O-])cc(C(=O)[O-])n1C,nitro
170825,Remove a amide from the molecule CCCCN1CCN(C(=O)c2ccc(-c3ccsc3)nc2)CC1.,CCCCN1CCN(C(=O)c2ccc(-c3ccsc3)nc2)CC1,amide
214835,Remove a hydroxyl from the molecule COC(=O)c1ccc(/C=C(/C)CO)o1.,COC(=O)c1ccc(/C=C(/C)CO)o1,hydroxyl
54079,Please remove a halo from the molecule O=C(Nc1ncc(Cc2ccc(OC(F)(F)F)cc2)s1)c1cccnc1.,O=C(Nc1ncc(Cc2ccc(OC(F)(F)F)cc2)s1)c1cccnc1,halo
235345,Remove a nitrile from the molecule CN1C(=O)N[C@](C)([C@H]2CCC[NH+](Cc3cccc(C#N)c3)C2)C1=O.,CN1C(=O)N[C@](C)([C@H]2CCC[NH+](Cc3cccc(C#N)c3)C2)C1=O,nitrile
160409,Remove a amide from the molecule Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CCNC(=O)c2snnc2C)cc1.,Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CCNC(=O)c2snnc2C)cc1,amide
238083,Modify the molecule Cc1cc(C)cc([C@@H](O)C2(C#N)CCCCC2)c1 by removing a hydroxyl.,Cc1cc(C)cc([C@@H](O)C2(C#N)CCCCC2)c1,hydroxyl
87879,Remove a benzene_ring from the molecule Cc1ccc([C@@H](NC(=O)Cc2n[nH]c(=O)c3ccccc23)C2CC2)cc1.,Cc1ccc([C@@H](NC(=O)Cc2n[nH]c(=O)c3ccccc23)C2CC2)cc1,benzene_ring
166892,Please remove a nitro from the molecule C#CC[C@H](OC(=O)Cn1cnc([N+](=O)[O-])n1)c1ccccn1.,C#CC[C@H](OC(=O)Cn1cnc([N+](=O)[O-])n1)c1ccccn1,nitro
247847,Modify the molecule CCc1ccc(NC(=O)C(=O)NCC[NH+]2CCN(c3ccccc3)CC2)cc1 by removing a amide.,CCc1ccc(NC(=O)C(=O)NCC[NH+]2CCN(c3ccccc3)CC2)cc1,amide
108699,Remove a amide from the molecule O=C(CCn1nnc2ccccc21)N1CCC[C@H]1c1nc2ccccc2[nH]1.,O=C(CCn1nnc2ccccc21)N1CCC[C@H]1c1nc2ccccc2[nH]1,amide
120363,Modify the molecule COc1cccc(C[NH2+][C@H](C)c2ccc(C#N)cc2)c1OC by removing a benzene_ring.,COc1cccc(C[NH2+][C@H](C)c2ccc(C#N)cc2)c1OC,benzene_ring
234264,Modify the molecule Cc1ccccc1-c1ccc(Cl)c(O)c1 by removing a benzene_ring.,Cc1ccccc1-c1ccc(Cl)c(O)c1,benzene_ring
136714,Please remove a amine from the molecule CCn1nc(C)c(-c2ccnc(NCc3cnn(Cc4ccccc4)c3)n2)c1C.,CCn1nc(C)c(-c2ccnc(NCc3cnn(Cc4ccccc4)c3)n2)c1C,amine
245873,Modify the molecule O=C(NCC1(c2ccccc2)CCCCCC1)NNC(=O)[C@H]1CCCO1 by removing a benzene_ring.,O=C(NCC1(c2ccccc2)CCCCCC1)NNC(=O)[C@H]1CCCO1,benzene_ring
171540,Modify the molecule Cc1ccc(CC(=O)c2cc(F)c(C)cc2F)cc1 by removing a halo.,Cc1ccc(CC(=O)c2cc(F)c(C)cc2F)cc1,halo
233646,Please remove a amide from the molecule O=C(Cc1cc(Cl)c2c(c1)OCCO2)Nc1ccncc1.,O=C(Cc1cc(Cl)c2c(c1)OCCO2)Nc1ccncc1,amide
133471,Remove a amide from the molecule CSCC[C@H](NC(=O)c1cc(Cl)nc(Cl)c1)c1nnc2ccccn12.,CSCC[C@H](NC(=O)c1cc(Cl)nc(Cl)c1)c1nnc2ccccn12,amide
158441,Remove a amide from the molecule Cc1n[nH]c2ncc(C(=O)NC[C@@H]3COc4ccccc4O3)cc12.,Cc1n[nH]c2ncc(C(=O)NC[C@@H]3COc4ccccc4O3)cc12,amide
35828,Modify the molecule O=C(N[C@H]1CCCc2ccccc21)c1ccc([N+](=O)[O-])s1 by removing a amide.,O=C(N[C@H]1CCCc2ccccc21)c1ccc([N+](=O)[O-])s1,amide
166624,Remove a amine from the molecule C=CCNc1nc(N2CCCCC2)nc(N2CCCCC2)n1.,C=CCNc1nc(N2CCCCC2)nc(N2CCCCC2)n1,amine
201469,Modify the molecule Cc1ccccc1-c1nc(C(=O)Nc2cccc(C)c2C(N)=O)cs1 by removing a amide.,Cc1ccccc1-c1nc(C(=O)Nc2cccc(C)c2C(N)=O)cs1,amide
118760,Please remove a amide from the molecule COc1ccc(NC(=O)CC[NH+]2CCC(NC(=O)C3CC3)CC2)cc1.,COc1ccc(NC(=O)CC[NH+]2CCC(NC(=O)C3CC3)CC2)cc1,amide
123100,Modify the molecule O=C(NC1CCC(O)CC1)[C@@H]1C[C@@H]1c1cccc(Br)c1 by removing a hydroxyl.,O=C(NC1CCC(O)CC1)[C@@H]1C[C@@H]1c1cccc(Br)c1,hydroxyl
244402,Modify the molecule CCc1nc2c(s1)[C@H]([NH2+]CCOc1ccc(Cl)cn1)CCC2 by removing a halo.,CCc1nc2c(s1)[C@H]([NH2+]CCOc1ccc(Cl)cn1)CCC2,halo
6059,Modify the molecule O=C(NCCc1ccccc1Cl)N[C@H](CO)c1ccco1 by removing a halo.,O=C(NCCc1ccccc1Cl)N[C@H](CO)c1ccco1,halo
172657,Remove a amide from the molecule Cn1cc([C@H]2C[C@@H]2C(=O)OCC(=O)NC2CCCCC2)cn1.,Cn1cc([C@H]2C[C@@H]2C(=O)OCC(=O)NC2CCCCC2)cn1,amide
63310,Remove a amide from the molecule C=CCN(Cc1cccs1)C(=O)N[C@@H](C)C(=O)N1CCCCC1.,C=CCN(Cc1cccs1)C(=O)N[C@@H](C)C(=O)N1CCCCC1,amide
122381,Please remove a hydroxyl from the molecule COc1cc([C@@H](C)[NH2+]C[C@@]2(O)CCOC2)ccc1F.,COc1cc([C@@H](C)[NH2+]C[C@@]2(O)CCOC2)ccc1F,hydroxyl
99489,Remove a amide from the molecule Cc1ccc(N2C[C@H](C(=O)N3CCN(c4nccn4-c4cccc(Cl)c4)CC3)CC2=O)cc1C.,Cc1ccc(N2C[C@H](C(=O)N3CCN(c4nccn4-c4cccc(Cl)c4)CC3)CC2=O)cc1C,amide
227736,Modify the molecule O=C(Nc1ccccn1)[C@H]1CCCN1C(=O)c1ccc(Cl)c(Cl)c1 by removing a halo.,O=C(Nc1ccccn1)[C@H]1CCCN1C(=O)c1ccc(Cl)c(Cl)c1,halo
182068,Modify the molecule CCOc1ccc(NC(=S)N2C[C@@H](C)O[C@H](C)C2)cc1 by removing a benzene_ring.,CCOc1ccc(NC(=S)N2C[C@@H](C)O[C@H](C)C2)cc1,benzene_ring
228480,Remove a halo from the molecule Cc1ccc(NC(=O)Cc2csc(-c3cnccn3)n2)cc1C(F)(F)F.,Cc1ccc(NC(=O)Cc2csc(-c3cnccn3)n2)cc1C(F)(F)F,halo
208916,Modify the molecule C[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)nc1 by removing a amide.,C[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)nc1,amide
129962,Remove a amide from the molecule CC(=O)N1CCN(C(=O)C[NH+]2CCCC[C@H]2Cn2cncn2)CC1.,CC(=O)N1CCN(C(=O)C[NH+]2CCCC[C@H]2Cn2cncn2)CC1,amide
204798,Remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N(C)c2ccc(OC(=O)c3ccccn3)cc2)cc1C.,Cc1ccc(S(=O)(=O)N(C)c2ccc(OC(=O)c3ccccn3)cc2)cc1C,benzene_ring
216396,Remove a amine from the molecule CC(C)(C)c1cccc(NN)c1.,CC(C)(C)c1cccc(NN)c1,amine
216900,Remove a amide from the molecule C[C@H]1CCC[C@H](C)N1C(=O)[C@@H](C)[NH+]1CCN(CC(=O)N2CCCC2)CC1.,C[C@H]1CCC[C@H](C)N1C(=O)[C@@H](C)[NH+]1CCN(CC(=O)N2CCCC2)CC1,amide
109952,Remove a benzene_ring from the molecule COC(=O)/C(=C/c1cccc([N+](=O)[O-])c1)Cn1cncn1.,COC(=O)/C(=C/c1cccc([N+](=O)[O-])c1)Cn1cncn1,benzene_ring
33083,Modify the molecule O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1ccc(N2CCOCC2)cc1 by removing a benzene_ring.,O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1ccc(N2CCOCC2)cc1,benzene_ring
58359,Please remove a benzene_ring from the molecule COc1ccc(Br)c(COc2ccc(CC[NH3+])nc2)c1.,COc1ccc(Br)c(COc2ccc(CC[NH3+])nc2)c1,benzene_ring
68005,Remove a benzene_ring from the molecule CC[C@@H](c1ccccc1)[C@@H]1CCCN1C(=O)CSc1nnnn1C.,CC[C@@H](c1ccccc1)[C@@H]1CCCN1C(=O)CSc1nnnn1C,benzene_ring
211355,Modify the molecule COc1ccc(Cl)c2c1N[C@@H](c1ccc(C(=O)[O-])cc1)[C@@H]1CC=C[C@H]21 by removing a amine.,COc1ccc(Cl)c2c1N[C@@H](c1ccc(C(=O)[O-])cc1)[C@@H]1CC=C[C@H]21,amine
131680,Please remove a benzene_ring from the molecule COC(=O)C1[C@@H](c2ccccc2)C(C(=O)[O-])[C@@H]1c1ccccc1.,COC(=O)C1[C@@H](c2ccccc2)C(C(=O)[O-])[C@@H]1c1ccccc1,benzene_ring
246587,Remove a halo from the molecule O=C(Oc1ccc2cc(-c3ccc(Cl)cc3)c(=O)oc2c1)[C@@H]1CCCO1.,O=C(Oc1ccc2cc(-c3ccc(Cl)cc3)c(=O)oc2c1)[C@@H]1CCCO1,halo
204463,Please remove a amide from the molecule CC[NH+]1CCC[C@@H]1CN1C[C@H](C(=O)NCc2ccc(C(N)=O)o2)CC1=O.,CC[NH+]1CCC[C@@H]1CN1C[C@H](C(=O)NCc2ccc(C(N)=O)o2)CC1=O,amide
90694,Modify the molecule Cc1nc(C)n([C@@H]2CCCN(C(=O)CC[C@H]3CCCO3)C2)n1 by removing a amide.,Cc1nc(C)n([C@@H]2CCCN(C(=O)CC[C@H]3CCCO3)C2)n1,amide
192910,Modify the molecule COc1ccc(NC(=S)N[C@H](NC(=O)N2CCOCC2)C(Cl)(Cl)Cl)cc1 by removing a halo.,COc1ccc(NC(=S)N[C@H](NC(=O)N2CCOCC2)C(Cl)(Cl)Cl)cc1,halo
81615,Please remove a benzene_ring from the molecule CC(=O)Nc1ccc(NS(=O)(=O)c2ccc3oc(=O)ccc3c2)cc1.,CC(=O)Nc1ccc(NS(=O)(=O)c2ccc3oc(=O)ccc3c2)cc1,benzene_ring
155666,Please remove a amide from the molecule Cc1cc(C)c(/C=N/NC(=O)COc2ccc([N+](=O)[O-])cc2)c(C)c1.,Cc1cc(C)c(/C=N/NC(=O)COc2ccc([N+](=O)[O-])cc2)c(C)c1,amide
245364,Please remove a halo from the molecule Cc1[nH]ncc1CCCNC(=O)N[C@H](C)c1ccc(Br)cc1.,Cc1[nH]ncc1CCCNC(=O)N[C@H](C)c1ccc(Br)cc1,halo
61045,Please remove a halo from the molecule COc1ccc2c(c1)C(N1CCN(C(=O)c3ccccc3F)[C@@H](C)C1)=Nc1ccccc1O2.,COc1ccc2c(c1)C(N1CCN(C(=O)c3ccccc3F)[C@@H](C)C1)=Nc1ccccc1O2,halo
232373,Modify the molecule COc1cccc(CO[C@H](C)C(=O)N[C@H]2C[C@@H](C)N(c3ccccc3)C2)c1 by removing a amide.,COc1cccc(CO[C@H](C)C(=O)N[C@H]2C[C@@H](C)N(c3ccccc3)C2)c1,amide
120867,Remove a amide from the molecule CC(C)N(Cc1cnn(C)c1)C(=O)[C@H]1CCC(=O)N(CCN2CCOCC2)C1.,CC(C)N(Cc1cnn(C)c1)C(=O)[C@H]1CCC(=O)N(CCN2CCOCC2)C1,amide
217716,Please remove a amide from the molecule CO[C@@H]1CCCC[C@H]1NC(=O)/C=C/c1cnc(C(C)(C)C)s1.,CO[C@@H]1CCCC[C@H]1NC(=O)/C=C/c1cnc(C(C)(C)C)s1,amide
214353,Modify the molecule CCNC(=O)C1CC[NH+](CC(=O)N[C@H](c2ccccc2)C2CC2)CC1 by removing a amide.,CCNC(=O)C1CC[NH+](CC(=O)N[C@H](c2ccccc2)C2CC2)CC1,amide
144889,Please remove a benzene_ring from the molecule CCOC(=O)c1cccc(N[C@H]2CSCC(C)(C)C2)c1.,CCOC(=O)c1cccc(N[C@H]2CSCC(C)(C)C2)c1,benzene_ring
214038,Please remove a halo from the molecule Clc1ccnc(CSc2nnc3n2CCCCC3)c1.,Clc1ccnc(CSc2nnc3n2CCCCC3)c1,halo
39227,Remove a benzene_ring from the molecule Cc1cc(C)c(C[S@](=O)[C@H](C)c2nc(-c3ccccc3)no2)c(C)c1.,Cc1cc(C)c(C[S@](=O)[C@H](C)c2nc(-c3ccccc3)no2)c(C)c1,benzene_ring
143467,Remove a halo from the molecule Cc1nn(C)cc1[C@@H](C)NC(=O)c1csc(-c2ccc(Cl)cc2)n1.,Cc1nn(C)cc1[C@@H](C)NC(=O)c1csc(-c2ccc(Cl)cc2)n1,halo
20921,Remove a amide from the molecule CCc1cc(C(=O)N[C@@H]2CCCC[C@@H]2C[NH+](C)C)n(C)n1.,CCc1cc(C(=O)N[C@@H]2CCCC[C@@H]2C[NH+](C)C)n(C)n1,amide
203216,Remove a benzene_ring from the molecule O=C(NC[C@@H]1COc2ccccc2O1)[C@H]1CCCN1C(=O)OCc1ccccc1.,O=C(NC[C@@H]1COc2ccccc2O1)[C@H]1CCCN1C(=O)OCc1ccccc1,benzene_ring
175496,Modify the molecule CC[C@@H]1CCCCN1C(=O)C[C@@H]1C=CCC1 by removing a amide.,CC[C@@H]1CCCCN1C(=O)C[C@@H]1C=CCC1,amide
94285,Remove a benzene_ring from the molecule Clc1ccccc1-c1nc(Cn2nccc2-c2ccncc2)no1.,Clc1ccccc1-c1nc(Cn2nccc2-c2ccncc2)no1,benzene_ring
10540,Please remove a hydroxyl from the molecule C=C(C)C[C@@H](O)[C@]1([NH+](C)C)CCC[C@@H](C)C1.,C=C(C)C[C@@H](O)[C@]1([NH+](C)C)CCC[C@@H](C)C1,hydroxyl
129696,Modify the molecule CCOc1ccc(CC(=O)Nc2sc3c(c2C#N)CCCCC3)cc1 by removing a benzene_ring.,CCOc1ccc(CC(=O)Nc2sc3c(c2C#N)CCCCC3)cc1,benzene_ring
192987,Modify the molecule Cc1cc(C)c(C#N)c(SCC(=O)Nc2ccccc2SCC#N)n1 by removing a amide.,Cc1cc(C)c(C#N)c(SCC(=O)Nc2ccccc2SCC#N)n1,amide
97812,Modify the molecule Cc1ncn(C[C@@H](C)[NH2+]CC(C)(C)c2ccccc2Cl)c1C by removing a halo.,Cc1ncn(C[C@@H](C)[NH2+]CC(C)(C)c2ccccc2Cl)c1C,halo
165186,Remove a benzene_ring from the molecule Cc1cc(C)c(S(=O)(=O)N(Cc2ccco2)Cc2cc3cccc(C)c3[nH]c2=O)c(C)c1.,Cc1cc(C)c(S(=O)(=O)N(Cc2ccco2)Cc2cc3cccc(C)c3[nH]c2=O)c(C)c1,benzene_ring
117958,Remove a benzene_ring from the molecule CNS(=O)(=O)Cc1ccccc1CNC(=O)c1c(-c2ccccc2)noc1C.,CNS(=O)(=O)Cc1ccccc1CNC(=O)c1c(-c2ccccc2)noc1C,benzene_ring
6629,Please remove a amine from the molecule CCCNc1ncc(C[NH+]2C[C@H](C)C[C@@H](C)C2)s1.,CCCNc1ncc(C[NH+]2C[C@H](C)C[C@@H](C)C2)s1,amine
224089,Remove a amide from the molecule C[C@H](C(=O)N1CCCCC1)N(c1ccc(Oc2ccccc2)cc1)S(C)(=O)=O.,C[C@H](C(=O)N1CCCCC1)N(c1ccc(Oc2ccccc2)cc1)S(C)(=O)=O,amide
70286,Modify the molecule C[C@@H](NC(=O)c1ccoc1)C(=O)N[C@H](C)c1noc(Cc2ccccc2)n1 by removing a amide.,C[C@@H](NC(=O)c1ccoc1)C(=O)N[C@H](C)c1noc(Cc2ccccc2)n1,amide
187080,Please remove a benzene_ring from the molecule O=C(C[C@H]1CCS(=O)(=O)C1)OCc1nccn1Cc1ccccc1.,O=C(C[C@H]1CCS(=O)(=O)C1)OCc1nccn1Cc1ccccc1,benzene_ring
88142,Modify the molecule COC(=O)c1c(S(=O)(=O)Nc2ccc(C)c(F)c2)sc2c1CCN(C(=O)c1csnn1)C2 by removing a amide.,COC(=O)c1c(S(=O)(=O)Nc2ccc(C)c(F)c2)sc2c1CCN(C(=O)c1csnn1)C2,amide
234892,Remove a thiol from the molecule OC[C@@H]1CCCC[NH+]1CCS.,OC[C@@H]1CCCC[NH+]1CCS,thiol
25481,Modify the molecule COC(=O)c1ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1 by removing a benzene_ring.,COC(=O)c1ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1,benzene_ring
225583,Modify the molecule [O-]c1nc(N2CCc3ccccc3C2)nc2ncn(-c3ccc(Cl)c(Cl)c3)c(=S)c12 by removing a benzene_ring.,[O-]c1nc(N2CCc3ccccc3C2)nc2ncn(-c3ccc(Cl)c(Cl)c3)c(=S)c12,benzene_ring
67389,Remove a nitrile from the molecule CC(C)c1nc(C[S@](=O)CCCCC#N)cs1.,CC(C)c1nc(C[S@](=O)CCCCC#N)cs1,nitrile
244994,Remove a benzene_ring from the molecule Cc1ccc(C)c(CC(=O)c2ccc(F)c(F)c2F)c1.,Cc1ccc(C)c(CC(=O)c2ccc(F)c(F)c2F)c1,benzene_ring
133265,Modify the molecule CC(C)c1ccc(NC(=O)C2=CN(C)[C@H]3C(=O)N(Cc4ccccc4)C(=O)N=C23)cc1 by removing a amide.,CC(C)c1ccc(NC(=O)C2=CN(C)[C@H]3C(=O)N(Cc4ccccc4)C(=O)N=C23)cc1,amide
122626,Remove a benzene_ring from the molecule C[NH+](C)[C@H]1CC[C@@H](NC(=O)c2ccccc2CSc2nc3ccccc3[nH]2)C1.,C[NH+](C)[C@H]1CC[C@@H](NC(=O)c2ccccc2CSc2nc3ccccc3[nH]2)C1,benzene_ring
40756,Remove a amide from the molecule Cc1ccccc1-c1cc(C(=O)NCC(C)(C)C[NH+](C)C)c2cnn(C(C)C)c2n1.,Cc1ccccc1-c1cc(C(=O)NCC(C)(C)C[NH+](C)C)c2cnn(C(C)C)c2n1,amide
248645,Remove a benzene_ring from the molecule Cc1ccc(NC(=O)N(C)Cc2[nH+]ccn2C)cc1C.,Cc1ccc(NC(=O)N(C)Cc2[nH+]ccn2C)cc1C,benzene_ring
228989,Modify the molecule CNC(=O)c1ccccc1NC(=O)C[C@H](c1ccccc1)C(C)C by removing a amide.,CNC(=O)c1ccccc1NC(=O)C[C@H](c1ccccc1)C(C)C,amide
61863,Please remove a amide from the molecule CCO[C@H](C)c1nc(CC(=O)Nc2cccc(-c3cn[nH]c3)c2)cs1.,CCO[C@H](C)c1nc(CC(=O)Nc2cccc(-c3cn[nH]c3)c2)cs1,amide
126104,Modify the molecule CC(=O)c1ccn(Cc2ccc([N+](=O)[O-])cc2Br)c1 by removing a nitro.,CC(=O)c1ccn(Cc2ccc([N+](=O)[O-])cc2Br)c1,nitro
137979,Remove a halo from the molecule Cc1cc(Br)cnc1N1CCC[C@H]1CCC[NH3+].,Cc1cc(Br)cnc1N1CCC[C@H]1CCC[NH3+],halo
28973,Modify the molecule C[NH2+][C@H]1CCN(CCc2ccc(F)cc2C)C1 by removing a benzene_ring.,C[NH2+][C@H]1CCN(CCc2ccc(F)cc2C)C1,benzene_ring
138898,Modify the molecule COC(=O)c1cc(NC(=O)c2cc(C3CC3)nc3c2c(C)nn3C(C)(C)C)ccc1F by removing a benzene_ring.,COC(=O)c1cc(NC(=O)c2cc(C3CC3)nc3c2c(C)nn3C(C)(C)C)ccc1F,benzene_ring
181435,Modify the molecule COc1c(Cl)cccc1NC(=O)C(=O)N[C@H]1C[C@@](C)(OC)C1(C)C by removing a benzene_ring.,COc1c(Cl)cccc1NC(=O)C(=O)N[C@H]1C[C@@](C)(OC)C1(C)C,benzene_ring
28534,Remove a amide from the molecule Cc1nc(N(C)C)sc1C[NH+]1CCC[C@@H](CC(N)=O)C1.,Cc1nc(N(C)C)sc1C[NH+]1CCC[C@@H](CC(N)=O)C1,amide
56649,Modify the molecule Cn1c(/C(C#N)=C/c2ccc(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)o2)nc2ccccc21 by removing a benzene_ring.,Cn1c(/C(C#N)=C/c2ccc(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)o2)nc2ccccc21,benzene_ring
35125,Modify the molecule CC(C)(O)CC[C@H]1C[C@@H](C(C)(C)C)CCC1=O by removing a hydroxyl.,CC(C)(O)CC[C@H]1C[C@@H](C(C)(C)C)CCC1=O,hydroxyl
171041,Remove a benzene_ring from the molecule CC[NH+]1CCN(c2ccc(N3CCC[C@H](C(=O)NCc4ccccc4)C3)nn2)CC1.,CC[NH+]1CCN(c2ccc(N3CCC[C@H](C(=O)NCc4ccccc4)C3)nn2)CC1,benzene_ring
39183,Please remove a amide from the molecule NC(=O)c1cccc(CNC(=O)NCC2(N3CCOCC3)CCCCC2)c1.,NC(=O)c1cccc(CNC(=O)NCC2(N3CCOCC3)CCCCC2)c1,amide
237918,Please remove a amide from the molecule Cn1nc(C(=O)Nc2ccccc2OC(F)(F)F)ccc1=O.,Cn1nc(C(=O)Nc2ccccc2OC(F)(F)F)ccc1=O,amide
144587,Remove a amide from the molecule NC(=O)C(=O)NC1CCCCC1.,NC(=O)C(=O)NC1CCCCC1,amide
34456,Please remove a hydroxyl from the molecule COC(=O)c1ccc(CSCCO)nc1.,COC(=O)c1ccc(CSCCO)nc1,hydroxyl
38328,Modify the molecule CCC(=O)Oc1ccc2c(c1C)O/C(=C\c1cccc([N+](=O)[O-])c1)C2=O by removing a benzene_ring.,CCC(=O)Oc1ccc2c(c1C)O/C(=C\c1cccc([N+](=O)[O-])c1)C2=O,benzene_ring
235954,Modify the molecule Cn1c(Cl)cnc1COC(=O)c1cc(Cl)c2c(c1)OCCO2 by removing a halo.,Cn1c(Cl)cnc1COC(=O)c1cc(Cl)c2c(c1)OCCO2,halo
98989,Remove a hydroxyl from the molecule C[C@@H](C#N)[C@H](O)[C@H]1CC=CCC1.,C[C@@H](C#N)[C@H](O)[C@H]1CC=CCC1,hydroxyl
2699,Please remove a amine from the molecule CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1.,CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1,amine
17480,Remove a amide from the molecule COc1ccc(C(=O)NC[C@@H]2CCCC[C@@H]2C[NH3+])cc1O.,COc1ccc(C(=O)NC[C@@H]2CCCC[C@@H]2C[NH3+])cc1O,amide
50098,Modify the molecule CC[C@@H]1CCCC[C@@H]1NC(=O)C[C@H]1OCCc2ccccc21 by removing a amide.,CC[C@@H]1CCCC[C@@H]1NC(=O)C[C@H]1OCCc2ccccc21,amide
154462,Please remove a hydroxyl from the molecule COc1cc(/C=N/NC(=O)COc2cc(C)c(Cl)c(C)c2Br)ccc1O.,COc1cc(/C=N/NC(=O)COc2cc(C)c(Cl)c(C)c2Br)ccc1O,hydroxyl
74420,Modify the molecule CC(=O)N(C(C)=O)c1ccccc1/C=C1/CCOC1=O by removing a benzene_ring.,CC(=O)N(C(C)=O)c1ccccc1/C=C1/CCOC1=O,benzene_ring
67834,Please remove a benzene_ring from the molecule COc1ccc(OCCNC(=O)N[C@@H]2CCC[C@@H]([NH+](C)C)C2)cc1.,COc1ccc(OCCNC(=O)N[C@@H]2CCC[C@@H]([NH+](C)C)C2)cc1,benzene_ring
45718,Please remove a amine from the molecule CCOC(=O)c1noc2nc(C)nc(NCCC3=CCCCC3)c12.,CCOC(=O)c1noc2nc(C)nc(NCCC3=CCCCC3)c12,amine
212051,Please remove a benzene_ring from the molecule C[C@H]1C[C@@H]([NH2+]Cc2ccccn2)CCN1Cc1ccccc1.,C[C@H]1C[C@@H]([NH2+]Cc2ccccn2)CCN1Cc1ccccc1,benzene_ring
85152,Please remove a benzene_ring from the molecule CCO[C@@H]1CCC[NH+](CC(=O)N(C)[C@@H](C)c2ccc(Cl)cc2)C1.,CCO[C@@H]1CCC[NH+](CC(=O)N(C)[C@@H](C)c2ccc(Cl)cc2)C1,benzene_ring
211623,Remove a amide from the molecule Cc1nc2c(c(C)c1CCC(=O)NCc1ccc(=O)[nH]c1)c(=O)[nH]n2C.,Cc1nc2c(c(C)c1CCC(=O)NCc1ccc(=O)[nH]c1)c(=O)[nH]n2C,amide
133690,Modify the molecule C[C@@H]1CCN(C(=O)N[C@@H]2CCC[C@@H]2c2ccc(F)cc2)C[C@H]1O by removing a halo.,C[C@@H]1CCN(C(=O)N[C@@H]2CCC[C@@H]2c2ccc(F)cc2)C[C@H]1O,halo
35983,Remove a benzene_ring from the molecule O=C1N[C@H](c2ccc(Cl)c(F)c2)Nc2ccccc21.,O=C1N[C@H](c2ccc(Cl)c(F)c2)Nc2ccccc21,benzene_ring
237623,Modify the molecule C[C@H]([NH3+])C(=O)N[C@H]1CCCC[C@H]1[NH+](Cc1ccccc1)C1CC1 by removing a benzene_ring.,C[C@H]([NH3+])C(=O)N[C@H]1CCCC[C@H]1[NH+](Cc1ccccc1)C1CC1,benzene_ring
33463,Remove a amide from the molecule O=C(COCc1nc2ccccc2s1)Nc1ccccc1N1CCCC1=O.,O=C(COCc1nc2ccccc2s1)Nc1ccccc1N1CCCC1=O,amide
90698,Modify the molecule C[C@H](O)C(=O)N1CCN(Cc2ccc(-c3nc4ccccc4s3)o2)CC1 by removing a amide.,C[C@H](O)C(=O)N1CCN(Cc2ccc(-c3nc4ccccc4s3)o2)CC1,amide
51652,Modify the molecule O=C(Nc1ccc(F)cc1)N[C@@H]1CCN(Cn2nccc2-c2ccncc2)C1 by removing a halo.,O=C(Nc1ccc(F)cc1)N[C@@H]1CCN(Cn2nccc2-c2ccncc2)C1,halo
177249,Remove a benzene_ring from the molecule Cc1ccc([C@@H]2CC=CC[C@@H]2[N+](=O)[O-])cc1.,Cc1ccc([C@@H]2CC=CC[C@@H]2[N+](=O)[O-])cc1,benzene_ring
17561,Modify the molecule CC(C)c1nc(C(=O)N[C@H](C)c2ccc(Cl)cc2Cl)n[nH]1 by removing a amide.,CC(C)c1nc(C(=O)N[C@H](C)c2ccc(Cl)cc2Cl)n[nH]1,amide
182984,Remove a benzene_ring from the molecule C=CCc1cc(/C=N/NC(=O)Nc2ccc(F)cc2)cc(OCC)c1O.,C=CCc1cc(/C=N/NC(=O)Nc2ccc(F)cc2)cc(OCC)c1O,benzene_ring
63740,Please remove a amide from the molecule Cc1cc(O[C@H](C)C(=O)Nc2cc([N+](=O)[O-])ccc2C)ccc1Cl.,Cc1cc(O[C@H](C)C(=O)Nc2cc([N+](=O)[O-])ccc2C)ccc1Cl,amide
797,Modify the molecule COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C by removing a benzene_ring.,COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C,benzene_ring
153213,Remove a amide from the molecule O=C(CN1CCCOC1=O)NCCc1nc(C(F)(F)F)cs1.,O=C(CN1CCCOC1=O)NCCc1nc(C(F)(F)F)cs1,amide
164211,Modify the molecule C[C@H]1CCC[C@H](C)N1C(=O)CCC(=O)N1[C@H](C)CCC[C@H]1C by removing a amide.,C[C@H]1CCC[C@H](C)N1C(=O)CCC(=O)N1[C@H](C)CCC[C@H]1C,amide
89730,Modify the molecule O=S(=O)(c1ccc(F)cc1)N1CCN(Cc2cnc3ccccn23)CC1 by removing a benzene_ring.,O=S(=O)(c1ccc(F)cc1)N1CCN(Cc2cnc3ccccn23)CC1,benzene_ring
189242,Remove a amide from the molecule CCN(CC1CC[NH2+]CC1)C(=O)Cc1cccs1.,CCN(CC1CC[NH2+]CC1)C(=O)Cc1cccs1,amide
244882,Modify the molecule CSc1ccc(C(C)=O)cc1F by removing a halo.,CSc1ccc(C(C)=O)cc1F,halo
87469,Please remove a nitro from the molecule Cc1ccccc1OCC(=O)N1CCN(c2ccc([N+](=O)[O-])c(N3CCOCC3)c2)CC1.,Cc1ccccc1OCC(=O)N1CCN(c2ccc([N+](=O)[O-])c(N3CCOCC3)c2)CC1,nitro
159737,Remove a benzene_ring from the molecule CC(C)NC(=O)CN(C)C(=O)CCc1nncn1-c1ccccc1.,CC(C)NC(=O)CN(C)C(=O)CCc1nncn1-c1ccccc1,benzene_ring
170411,Modify the molecule Cc1cc(F)cc(Nc2ccc(Cl)cn2)c1 by removing a benzene_ring.,Cc1cc(F)cc(Nc2ccc(Cl)cn2)c1,benzene_ring
243084,Please remove a halo from the molecule Cc1nc(C)c(C(=O)C2=C([O-])C(=O)N(CCc3ccccc3)[C@@H]2c2ccc(F)cc2)s1.,Cc1nc(C)c(C(=O)C2=C([O-])C(=O)N(CCc3ccccc3)[C@@H]2c2ccc(F)cc2)s1,halo
47774,Modify the molecule Cc1nn(C)c(C)c1CC(=O)[C@@H](C#N)c1ncc(C(F)(F)F)cc1Cl by removing a nitrile.,Cc1nn(C)c(C)c1CC(=O)[C@@H](C#N)c1ncc(C(F)(F)F)cc1Cl,nitrile
154413,Please remove a amide from the molecule C[C@@]1(CSc2ccccc2C(=O)N2CC[C@H]3CCCC[C@@H]3C2)NC(=O)NC1=O.,C[C@@]1(CSc2ccccc2C(=O)N2CC[C@H]3CCCC[C@@H]3C2)NC(=O)NC1=O,amide
211065,Please remove a amine from the molecule CNS(=O)(=O)c1ccc(-c2ccc(OC)cc2)cc1.,CNS(=O)(=O)c1ccc(-c2ccc(OC)cc2)cc1,amine
178119,Modify the molecule CN1CCc2nc3sc4c5c(c(=O)[nH]c4c3cc2C1)[C@@H](c1ccc(F)cc1)C(C#N)=C(N)O5 by removing a halo.,CN1CCc2nc3sc4c5c(c(=O)[nH]c4c3cc2C1)[C@@H](c1ccc(F)cc1)C(C#N)=C(N)O5,halo
197734,Modify the molecule Cn1nc(CC(C)(C)C)cc1NC(=O)C(=O)N[C@H]1C[C@H]1C1CCCCC1 by removing a amide.,Cn1nc(CC(C)(C)C)cc1NC(=O)C(=O)N[C@H]1C[C@H]1C1CCCCC1,amide
205955,Modify the molecule CCNC(=O)Nc1ccccc1OC by removing a benzene_ring.,CCNC(=O)Nc1ccccc1OC,benzene_ring
158609,Please remove a halo from the molecule CCCc1cc(NC(=O)c2ncccc2C(F)(F)F)n[nH]1.,CCCc1cc(NC(=O)c2ncccc2C(F)(F)F)n[nH]1,halo
213711,Remove a halo from the molecule O=C(NC[C@@H]1Cc2cc(F)cc(-c3ncccn3)c2O1)c1noc2c1CCCC2.,O=C(NC[C@@H]1Cc2cc(F)cc(-c3ncccn3)c2O1)c1noc2c1CCCC2,halo
22661,Modify the molecule Cc1ccc(C#N)c(N[C@H]2CCc3cc(N)ccc32)n1 by removing a nitrile.,Cc1ccc(C#N)c(N[C@H]2CCc3cc(N)ccc32)n1,nitrile
88137,Modify the molecule O=C(CSc1nnc(NC(=O)Cc2ccccc2)s1)Nc1ccc2c(c1)OCCO2 by removing a amide.,O=C(CSc1nnc(NC(=O)Cc2ccccc2)s1)Nc1ccc2c(c1)OCCO2,amide
82097,Please remove a benzene_ring from the molecule COc1ccc(-c2nnc(SCC(C)=O)n2C2CCCCC2)cc1.,COc1ccc(-c2nnc(SCC(C)=O)n2C2CCCCC2)cc1,benzene_ring
6612,Please remove a nitrile from the molecule C[S@](=O)c1ccc(CNc2cc(C#N)nc3ccccc23)cc1.,C[S@](=O)c1ccc(CNc2cc(C#N)nc3ccccc23)cc1,nitrile
234369,Please remove a amide from the molecule CC[NH+](CC)Cc1nc(C2(NC(=O)C3CC=CC3)CCCC2)no1.,CC[NH+](CC)Cc1nc(C2(NC(=O)C3CC=CC3)CCCC2)no1,amide
35049,Please remove a benzene_ring from the molecule CN(C)/C=C/C(=O)c1ccc(Sc2ccccc2)cc1.,CN(C)/C=C/C(=O)c1ccc(Sc2ccccc2)cc1,benzene_ring
66903,Modify the molecule Cc1csc(C[S@](=O)Cc2coc(-c3ccc(F)c(F)c3)n2)n1 by removing a halo.,Cc1csc(C[S@](=O)Cc2coc(-c3ccc(F)c(F)c3)n2)n1,halo
54338,Please remove a amide from the molecule Cc1ccoc1C(=O)N1CC[NH+](Cc2ccc3c(c2)OCCO3)CC1.,Cc1ccoc1C(=O)N1CC[NH+](Cc2ccc3c(c2)OCCO3)CC1,amide
21679,Modify the molecule C[C@@H]1OCC[C@@H]1C(=O)c1ccc(Br)cc1 by removing a benzene_ring.,C[C@@H]1OCC[C@@H]1C(=O)c1ccc(Br)cc1,benzene_ring
236870,Please remove a benzene_ring from the molecule CO[C@@H](C)C(=O)NNC(=O)CNc1ccc(C)cc1.,CO[C@@H](C)C(=O)NNC(=O)CNc1ccc(C)cc1,benzene_ring
172490,Modify the molecule C[C@@H](C(=O)Nc1ccc(Cl)cc1)S(=O)(=O)c1ccc(O)cc1 by removing a halo.,C[C@@H](C(=O)Nc1ccc(Cl)cc1)S(=O)(=O)c1ccc(O)cc1,halo
7789,Remove a benzene_ring from the molecule Cc1ccc(N(CCOC(=O)c2cccnc2)C2=NS(=O)(=O)c3ccccc32)cc1.,Cc1ccc(N(CCOC(=O)c2cccnc2)C2=NS(=O)(=O)c3ccccc32)cc1,benzene_ring
159075,Modify the molecule O=C(NCc1cccnc1)C(=O)NC[C@@H](c1cccs1)N1CCc2ccccc21 by removing a amide.,O=C(NCc1cccnc1)C(=O)NC[C@@H](c1cccs1)N1CCc2ccccc21,amide
43439,Modify the molecule C[C@H](N[C@H](C)CC(=O)N1CCCCCC1)C(=O)OC(C)(C)C by removing a amine.,C[C@H](N[C@H](C)CC(=O)N1CCCCCC1)C(=O)OC(C)(C)C,amine
159851,Modify the molecule C#CCNC(=O)[C@@H]1CCO[C@H]1C by removing a amide.,C#CCNC(=O)[C@@H]1CCO[C@H]1C,amide
207014,Remove a benzene_ring from the molecule CCc1ccccc1[N-]S(=O)(=O)c1cc(-c2nc(C)c(C(=O)N3CCCC3)s2)n(C)c1C.,CCc1ccccc1[N-]S(=O)(=O)c1cc(-c2nc(C)c(C(=O)N3CCCC3)s2)n(C)c1C,benzene_ring
190498,Please remove a benzene_ring from the molecule Cc1cc(N/N=C2/C[C@H](c3ccccc3)Oc3ccccc32)nc(C)n1.,Cc1cc(N/N=C2/C[C@H](c3ccccc3)Oc3ccccc32)nc(C)n1,benzene_ring
246971,Modify the molecule COc1ccc([C@H](NC(=O)NC[C@@H](C)N2CCOCC2)C(C)C)cc1 by removing a benzene_ring.,COc1ccc([C@H](NC(=O)NC[C@@H](C)N2CCOCC2)C(C)C)cc1,benzene_ring
88698,Remove a amine from the molecule O=C(NNc1cccnc1Cl)c1sccc1OC(F)F.,O=C(NNc1cccnc1Cl)c1sccc1OC(F)F,amine
129334,Modify the molecule O=C(NC[C@H]1COc2ccccc2O1)c1cc(-c2ccco2)nn1-c1ccccc1 by removing a benzene_ring.,O=C(NC[C@H]1COc2ccccc2O1)c1cc(-c2ccco2)nn1-c1ccccc1,benzene_ring
132763,Modify the molecule CC[C@@H](C)NC(=O)CCNC(=O)N[C@@H](C)C(C)C by removing a amide.,CC[C@@H](C)NC(=O)CCNC(=O)N[C@@H](C)C(C)C,amide
97442,Modify the molecule C[S@@](=O)c1ccc(CNC(=O)NC[C@@H](O)c2ccc(F)cc2)cc1 by removing a hydroxyl.,C[S@@](=O)c1ccc(CNC(=O)NC[C@@H](O)c2ccc(F)cc2)cc1,hydroxyl
55265,Modify the molecule C[C@H]1CN(S(=O)(=O)c2cccc([N+](=O)[O-])c2)C[C@H](C)O1 by removing a nitro.,C[C@H]1CN(S(=O)(=O)c2cccc([N+](=O)[O-])c2)C[C@H](C)O1,nitro
242161,Modify the molecule CCN1C(=O)[C@H](CC(=O)Nc2cc(Cl)ccc2C)S/C1=N\c1ccc(S(N)(=O)=O)cc1 by removing a benzene_ring.,CCN1C(=O)[C@H](CC(=O)Nc2cc(Cl)ccc2C)S/C1=N\c1ccc(S(N)(=O)=O)cc1,benzene_ring
238273,Modify the molecule CC1(C)[C@H]2CC[C@@](O)(C[NH3+])[C@@H]1C2 by removing a hydroxyl.,CC1(C)[C@H]2CC[C@@](O)(C[NH3+])[C@@H]1C2,hydroxyl
47360,Remove a benzene_ring from the molecule CCc1ccc(NC(=O)[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc1.,CCc1ccc(NC(=O)[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc1,benzene_ring
153544,Modify the molecule CCC[C@H]1C[NH2+]CC[C@@H]1c1ccc(OC)cc1 by removing a benzene_ring.,CCC[C@H]1C[NH2+]CC[C@@H]1c1ccc(OC)cc1,benzene_ring
30936,Modify the molecule CCOC(=O)CCCNc1ncnc2ccccc12 by removing a amine.,CCOC(=O)CCCNc1ncnc2ccccc12,amine
14543,Remove a benzene_ring from the molecule CCC(C)(C)c1ccc(OC[C@H](C)C[NH3+])cc1.,CCC(C)(C)c1ccc(OC[C@H](C)C[NH3+])cc1,benzene_ring
119600,Please remove a amide from the molecule C[C@]12CN(Cc3ccccc3)C[C@@H]1NC(=O)c1ccccc1[C@@H]2[NH3+].,C[C@]12CN(Cc3ccccc3)C[C@@H]1NC(=O)c1ccccc1[C@@H]2[NH3+],amide
153759,Remove a halo from the molecule CC[C@H](C#N)OC(=O)c1ccn(-c2ccccc2Cl)n1.,CC[C@H](C#N)OC(=O)c1ccn(-c2ccccc2Cl)n1,halo
124408,Modify the molecule Cc1ccc(CCNC(=O)C[C@H](O)c2cccc(F)c2)c(C)c1 by removing a amide.,Cc1ccc(CCNC(=O)C[C@H](O)c2cccc(F)c2)c(C)c1,amide
37791,Please remove a benzene_ring from the molecule CC(C)Cc1ccc([C@H](C)c2nn3c(-c4ccccn4)nnc3s2)cc1.,CC(C)Cc1ccc([C@H](C)c2nn3c(-c4ccccn4)nnc3s2)cc1,benzene_ring
47226,Modify the molecule F[C@H]1CCCC[C@@H]1Br by removing a halo.,F[C@H]1CCCC[C@@H]1Br,halo
57876,Please remove a hydroxyl from the molecule C[C@H](CNC(=O)N[C@@H]1CCc2c(O)cccc21)c1cccs1.,C[C@H](CNC(=O)N[C@@H]1CCc2c(O)cccc21)c1cccs1,hydroxyl
140986,Please remove a amide from the molecule CCC[C@@H]1CN(C(=O)c2ccc(=O)[nH]c2)C[C@H]1[NH+](C)C.,CCC[C@@H]1CN(C(=O)c2ccc(=O)[nH]c2)C[C@H]1[NH+](C)C,amide
18784,Please remove a halo from the molecule COc1ccc(-c2ccc(C[NH2+]Cc3ccc4c(c3)OCO4)o2)cc1Cl.,COc1ccc(-c2ccc(C[NH2+]Cc3ccc4c(c3)OCO4)o2)cc1Cl,halo
30862,Modify the molecule COc1ccc(NC(=O)[C@@H](C)Cc2ccccc2F)c(C)c1 by removing a amide.,COc1ccc(NC(=O)[C@@H](C)Cc2ccccc2F)c(C)c1,amide
159455,Remove a amide from the molecule O=C1[C@H](Oc2ccccc2)[C@H](c2cccs2)N1Cc1ccc2c(c1)OCO2.,O=C1[C@H](Oc2ccccc2)[C@H](c2cccs2)N1Cc1ccc2c(c1)OCO2,amide
136653,Remove a nitrile from the molecule C[C@H](NC(=O)N[C@@H]1C[C@@H]1C)c1ccc(C#N)cc1.,C[C@H](NC(=O)N[C@@H]1C[C@@H]1C)c1ccc(C#N)cc1,nitrile
32653,Modify the molecule CCCCN/C([O-])=N/S(=O)(=O)c1ccccc1-c1ccccc1 by removing a amine.,CCCCN/C([O-])=N/S(=O)(=O)c1ccccc1-c1ccccc1,amine
55314,Modify the molecule COc1cccc(C#CCOC(=O)c2cn(C)nc2C(C)(C)C)c1 by removing a benzene_ring.,COc1cccc(C#CCOC(=O)c2cn(C)nc2C(C)(C)C)c1,benzene_ring
81015,Modify the molecule c1ccc(Cn2nnnc2CN2CC[NH+](Cc3ccc4c(c3)OCO4)CC2)cc1 by removing a benzene_ring.,c1ccc(Cn2nnnc2CN2CC[NH+](Cc3ccc4c(c3)OCO4)CC2)cc1,benzene_ring
1730,Please remove a amide from the molecule O=C(NNc1cccc(C(F)(F)F)c1)c1cccc2cccnc12.,O=C(NNc1cccc(C(F)(F)F)c1)c1cccc2cccnc12,amide
246966,Please remove a amide from the molecule CN1CC[C@H](CNC(=O)Cn2ccc(=O)[nH]c2=O)c2ccccc21.,CN1CC[C@H](CNC(=O)Cn2ccc(=O)[nH]c2=O)c2ccccc21,amide
168204,Please remove a halo from the molecule C[C@H](CNC(=O)NC[C@@H]1CCC[C@H](O)C1)c1ccc(F)c(F)c1.,C[C@H](CNC(=O)NC[C@@H]1CCC[C@H](O)C1)c1ccc(F)c(F)c1,halo
218715,Remove a hydroxyl from the molecule CC[NH2+][C@]1(CO)CC[C@H](Sc2nnc3ccccn23)C1.,CC[NH2+][C@]1(CO)CC[C@H](Sc2nnc3ccccn23)C1,hydroxyl
52961,Please remove a benzene_ring from the molecule COc1ccc2c(c1)=[NH+][C@@H](C(=O)N1CCC([C@H](C)C(=O)NCc3ccc(Cl)cc3)CC1)C=2.,COc1ccc2c(c1)=[NH+][C@@H](C(=O)N1CCC([C@H](C)C(=O)NCc3ccc(Cl)cc3)CC1)C=2,benzene_ring
95187,Modify the molecule O[C@@H](C[NH+]1CCC(Oc2ccccc2)CC1)c1cccc(Cl)c1 by removing a benzene_ring.,O[C@@H](C[NH+]1CCC(Oc2ccccc2)CC1)c1cccc(Cl)c1,benzene_ring
100923,Please remove a amide from the molecule Cc1ccc([C@@H](C)NC(=O)c2cccc(-n3cccn3)n2)o1.,Cc1ccc([C@@H](C)NC(=O)c2cccc(-n3cccn3)n2)o1,amide
217222,Modify the molecule C[C@@H]1CCC[C@H]1NC(=O)Nc1cccn(Cc2ccc(F)cc2)c1=O by removing a benzene_ring.,C[C@@H]1CCC[C@H]1NC(=O)Nc1cccn(Cc2ccc(F)cc2)c1=O,benzene_ring
47475,Please remove a benzene_ring from the molecule COc1ccccc1C(=O)[C@@H]1CCOC2(CCOCC2)C1.,COc1ccccc1C(=O)[C@@H]1CCOC2(CCOCC2)C1,benzene_ring
108025,Remove a thiol from the molecule Sc1sccc1/C=N/c1ccc2ccccc2c1.,Sc1sccc1/C=N/c1ccc2ccccc2c1,thiol
181573,Please remove a benzene_ring from the molecule C[C@@H](NC(=O)C(=O)Nc1ccc2c(c1)COC2)c1cccc(-n2cccn2)c1.,C[C@@H](NC(=O)C(=O)Nc1ccc2c(c1)COC2)c1cccc(-n2cccn2)c1,benzene_ring
30115,Remove a halo from the molecule COc1ccc(C(=O)O[C@@H](C)[C@H]2CCCO2)cc1F.,COc1ccc(C(=O)O[C@@H](C)[C@H]2CCCO2)cc1F,halo
15445,Please remove a benzene_ring from the molecule CC(=O)C1=C(C)C(C(=O)NCc2ccc(-n3ccnc3)cc2)=N[C@H]1C.,CC(=O)C1=C(C)C(C(=O)NCc2ccc(-n3ccnc3)cc2)=N[C@H]1C,benzene_ring
67168,Modify the molecule C[C@@H]1[NH2+]CC[C@@H]1C(=O)Nc1cc(F)cc(F)c1 by removing a halo.,C[C@@H]1[NH2+]CC[C@@H]1C(=O)Nc1cc(F)cc(F)c1,halo
228884,Please remove a amide from the molecule CN(/C([O-])=N/c1ncnn1C)[C@@H]1CCCN(c2ccccc2)C1=O.,CN(/C([O-])=N/c1ncnn1C)[C@@H]1CCCN(c2ccccc2)C1=O,amide
70664,Remove a benzene_ring from the molecule COc1ccc(-c2csc(CNC(=O)c3cc(C)no3)c2)cc1.,COc1ccc(-c2csc(CNC(=O)c3cc(C)no3)c2)cc1,benzene_ring
6304,Modify the molecule Cc1ccc(-c2nnn(CC(=O)N[C@H]3CCCn4c(C)nnc43)n2)cc1 by removing a amide.,Cc1ccc(-c2nnn(CC(=O)N[C@H]3CCCn4c(C)nnc43)n2)cc1,amide
42099,Please remove a amide from the molecule O=C(NCc1ccon1)c1cc2ccccc2c(Cl)n1.,O=C(NCc1ccon1)c1cc2ccccc2c(Cl)n1,amide
29706,Please remove a benzene_ring from the molecule Cc1ccc(Cn2ccc3cc(CO)ccc32)cc1.,Cc1ccc(Cn2ccc3cc(CO)ccc32)cc1,benzene_ring
182253,Remove a benzene_ring from the molecule COc1ccc(CNC(=O)NC2CC[NH+](C[C@@H]3CCOC3)CC2)cc1.,COc1ccc(CNC(=O)NC2CC[NH+](C[C@@H]3CCOC3)CC2)cc1,benzene_ring
166655,Modify the molecule O=C(Nc1cc(N2CCCC2=O)ccc1Cl)N1CC[C@@H]([NH+]2CCCC2)C1 by removing a amide.,O=C(Nc1cc(N2CCCC2=O)ccc1Cl)N1CC[C@@H]([NH+]2CCCC2)C1,amide
223080,Modify the molecule CCOCCCNC(=O)[C@@H]1CC(=O)N(c2ccc(Cl)cc2)C1 by removing a amide.,CCOCCCNC(=O)[C@@H]1CC(=O)N(c2ccc(Cl)cc2)C1,amide
57771,Remove a halo from the molecule CC(C)(C)c1csc(C[C@H]2CCC[C@H](Br)C2)n1.,CC(C)(C)c1csc(C[C@H]2CCC[C@H](Br)C2)n1,halo
164202,Please remove a amide from the molecule O=C(NC12CC3CC(CC(C3)C1)C2)c1csc(-c2cnccn2)n1.,O=C(NC12CC3CC(CC(C3)C1)C2)c1csc(-c2cnccn2)n1,amide
39666,Remove a amide from the molecule COC1CC[NH+](CCNC(=O)c2cc(C)n(-c3cc(C)on3)c2C)CC1.,COC1CC[NH+](CCNC(=O)c2cc(C)n(-c3cc(C)on3)c2C)CC1,amide
11174,Modify the molecule [O-]/[N+](=C\c1ccc(O)cc1)c1ccc(Cl)cc1 by removing a halo.,[O-]/[N+](=C\c1ccc(O)cc1)c1ccc(Cl)cc1,halo
42120,Remove a halo from the molecule CC1(C)CCC[C@@H](Sc2ccc(Cl)cc2)[C@H]1[NH3+].,CC1(C)CCC[C@@H](Sc2ccc(Cl)cc2)[C@H]1[NH3+],halo
17225,Modify the molecule CCN1CC(=O)Nc2cc(C(=O)O[C@@H](C)C3CC3)ccc21 by removing a amide.,CCN1CC(=O)Nc2cc(C(=O)O[C@@H](C)C3CC3)ccc21,amide
64378,Remove a amide from the molecule CN(CCc1ccccc1)C(=O)c1ccc[n+]([O-])c1.,CN(CCc1ccccc1)C(=O)c1ccc[n+]([O-])c1,amide
102389,Please remove a hydroxyl from the molecule CC(C)[C@H](C(=O)N(C)C[C@H]1CCC[NH+]1C)/C(N)=N/O.,CC(C)[C@H](C(=O)N(C)C[C@H]1CCC[NH+]1C)/C(N)=N/O,hydroxyl
175631,Modify the molecule CCC(C)(C)[C@@H]1CCCN1C(=O)c1cnc2sc(C)cn2c1=O by removing a amide.,CCC(C)(C)[C@@H]1CCCN1C(=O)c1cnc2sc(C)cn2c1=O,amide
141860,Modify the molecule Cc1c(NC2=NCCS2)c(=O)n(-c2ccccc2)n1C by removing a amine.,Cc1c(NC2=NCCS2)c(=O)n(-c2ccccc2)n1C,amine
117082,Please remove a amide from the molecule COc1ccc(N2CCN(C(=O)C[C@@H]3C(=O)NCC[NH+]3C3CCCC3)CC2)cc1.,COc1ccc(N2CCN(C(=O)C[C@@H]3C(=O)NCC[NH+]3C3CCCC3)CC2)cc1,amide
217536,Please remove a amide from the molecule C[C@H](NC(=O)[C@@H]1CCO[C@@H]1C)C(=O)NC(C)(C)C.,C[C@H](NC(=O)[C@@H]1CCO[C@@H]1C)C(=O)NC(C)(C)C,amide
102534,Remove a benzene_ring from the molecule O=C1NCC(=O)N2CCN(C(=O)c3cnnn3-c3ccccc3)C[C@@H]12.,O=C1NCC(=O)N2CCN(C(=O)c3cnnn3-c3ccccc3)C[C@@H]12,benzene_ring
234504,Modify the molecule Cc1cccc(C(=O)N/N=C/c2cc3ccc(C)cc3nc2Cl)c1 by removing a benzene_ring.,Cc1cccc(C(=O)N/N=C/c2cc3ccc(C)cc3nc2Cl)c1,benzene_ring
98073,Modify the molecule C=CC[C@H](Sc1nnnn1-c1ccc(Cl)cc1)c1ccccc1 by removing a halo.,C=CC[C@H](Sc1nnnn1-c1ccc(Cl)cc1)c1ccccc1,halo
187709,Remove a amide from the molecule CNc1cc([C@H]2CCCN(C(=O)CC(C)(C)C)C2)nc(-c2cccnc2)n1.,CNc1cc([C@H]2CCCN(C(=O)CC(C)(C)C)C2)nc(-c2cccnc2)n1,amide
103706,Modify the molecule COc1c(Br)cccc1C[NH2+]Cc1ccco1 by removing a halo.,COc1c(Br)cccc1C[NH2+]Cc1ccco1,halo
244320,Please remove a amide from the molecule CCOc1ccc(C(=O)N[C@@]2(C)CCS(=O)(=O)C2)cn1.,CCOc1ccc(C(=O)N[C@@]2(C)CCS(=O)(=O)C2)cn1,amide
91206,Modify the molecule CC(C)[NH2+]C[C@@H](O)CN(C)C[C@@H]1CCC[NH+]1C by removing a hydroxyl.,CC(C)[NH2+]C[C@@H](O)CN(C)C[C@@H]1CCC[NH+]1C,hydroxyl
32658,Please remove a benzene_ring from the molecule CC[C@H](Oc1ccccc1)C(=O)Nc1cccc(C(=O)Nc2ccccc2)c1.,CC[C@H](Oc1ccccc1)C(=O)Nc1cccc(C(=O)Nc2ccccc2)c1,benzene_ring
101939,Please remove a benzene_ring from the molecule C[S@](=O)c1ccc(C[NH2+]C[C@H]2CN3CCCC[C@@H]3CO2)cc1.,C[S@](=O)c1ccc(C[NH2+]C[C@H]2CN3CCCC[C@@H]3CO2)cc1,benzene_ring
130454,Remove a amide from the molecule C=CCN1CCN(C2CCN(S(=O)(=O)c3ccccc3CC)CC2)C(=O)C1=O.,C=CCN1CCN(C2CCN(S(=O)(=O)c3ccccc3CC)CC2)C(=O)C1=O,amide
244746,Modify the molecule O=C(Cn1cnnn1)NC1(c2cccc(C(F)(F)F)c2)CCCCC1 by removing a amide.,O=C(Cn1cnnn1)NC1(c2cccc(C(F)(F)F)c2)CCCCC1,amide
134045,Please remove a benzene_ring from the molecule CCC[C@@H](NC(=O)c1ccc(Cl)c(OC)c1)C(=O)OC.,CCC[C@@H](NC(=O)c1ccc(Cl)c(OC)c1)C(=O)OC,benzene_ring
522,Modify the molecule CC(C)c1ccc2oc(-c3ccc(C[NH3+])cc3)nc2c1 by removing a benzene_ring.,CC(C)c1ccc2oc(-c3ccc(C[NH3+])cc3)nc2c1,benzene_ring
209263,Modify the molecule C[C@H](O)[C@@H]1CCCC[NH+]1Cc1cc(C#N)cs1 by removing a hydroxyl.,C[C@H](O)[C@@H]1CCCC[NH+]1Cc1cc(C#N)cs1,hydroxyl
96247,Modify the molecule Cc1ccc(O[C@@H](C)C(=O)NC(N)=O)c(C=O)n1 by removing a aldehyde.,Cc1ccc(O[C@@H](C)C(=O)NC(N)=O)c(C=O)n1,aldehyde
221173,Please remove a halo from the molecule CCc1cccc(CC)c1NC(=O)CSc1nnc(-c2ccc(F)cc2)o1.,CCc1cccc(CC)c1NC(=O)CSc1nnc(-c2ccc(F)cc2)o1,halo
50316,Modify the molecule C[C@H]1CCN(C(=O)C[C@@H]2CCCc3ccccc32)C[C@@H]1O by removing a amide.,C[C@H]1CCN(C(=O)C[C@@H]2CCCc3ccccc32)C[C@@H]1O,amide
7521,Modify the molecule CCOC(=O)c1cccc(N[C@H]2CS[C@@H](C)C2)c1 by removing a amine.,CCOC(=O)c1cccc(N[C@H]2CS[C@@H](C)C2)c1,amine
226564,Please remove a amide from the molecule O=C(Cn1ncn2nccc2c1=O)N1CCC[C@@H](n2cncn2)C1.,O=C(Cn1ncn2nccc2c1=O)N1CCC[C@@H](n2cncn2)C1,amide
206333,Please remove a benzene_ring from the molecule O=C(Cc1ccc(Cl)cc1)N1CCC[C@@H]1c1cccs1.,O=C(Cc1ccc(Cl)cc1)N1CCC[C@@H]1c1cccs1,benzene_ring
48367,Please remove a amide from the molecule O=C(Cc1ccncc1)NNC(=O)N[C@@H]1CCCC[C@H]1Cc1ccccc1.,O=C(Cc1ccncc1)NNC(=O)N[C@@H]1CCCC[C@H]1Cc1ccccc1,amide
50495,Remove a halo from the molecule C[NH2+][C@@H](COC(C)C)c1ncc(Cl)cc1Cl.,C[NH2+][C@@H](COC(C)C)c1ncc(Cl)cc1Cl,halo
206578,Modify the molecule OC1=Nc2c(cnn2Cc2ccccc2)[C@@H](c2ccc(F)c(F)c2F)SC1 by removing a hydroxyl.,OC1=Nc2c(cnn2Cc2ccccc2)[C@@H](c2ccc(F)c(F)c2F)SC1,hydroxyl
86493,Please remove a halo from the molecule O=C(NCc1nc(-c2cccs2)n[nH]1)c1cc2cccc(Cl)c2o1.,O=C(NCc1nc(-c2cccs2)n[nH]1)c1cc2cccc(Cl)c2o1,halo
152221,Please remove a amide from the molecule O=C(NC1C2CC3CC(C2)CC1C3)C1CCC1.,O=C(NC1C2CC3CC(C2)CC1C3)C1CCC1,amide
56851,Please remove a benzene_ring from the molecule C[C@H]1CN(C(=O)c2ccc(-c3ncon3)cc2)C(C)(C)CO1.,C[C@H]1CN(C(=O)c2ccc(-c3ncon3)cc2)C(C)(C)CO1,benzene_ring
102071,Please remove a nitrile from the molecule N#Cc1csc(C(=O)Oc2ccc(Br)cc2)c1.,N#Cc1csc(C(=O)Oc2ccc(Br)cc2)c1,nitrile
29420,Please remove a benzene_ring from the molecule Oc1cccc(C[NH+]2CCC(n3cc(-c4ccccc4)nn3)CC2)c1.,Oc1cccc(C[NH+]2CCC(n3cc(-c4ccccc4)nn3)CC2)c1,benzene_ring
104933,Modify the molecule ClC[C@@H]1CCO[C@@H]1c1cc(Br)c(Br)o1 by removing a halo.,ClC[C@@H]1CCO[C@@H]1c1cc(Br)c(Br)o1,halo
239221,Remove a hydroxyl from the molecule O=S(=O)(Cc1cccc(F)c1)N[C@@H](CO)c1ccc(Cl)cc1.,O=S(=O)(Cc1cccc(F)c1)N[C@@H](CO)c1ccc(Cl)cc1,hydroxyl
75746,Remove a halo from the molecule COc1cc(/C=C(\C#N)C(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1O.,COc1cc(/C=C(\C#N)C(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1O,halo
209211,Please remove a benzene_ring from the molecule CN(CC1CC[NH2+]CC1)C[C@H](C#N)c1ccccc1.,CN(CC1CC[NH2+]CC1)C[C@H](C#N)c1ccccc1,benzene_ring
91422,Please remove a benzene_ring from the molecule CCN(CC)C(=O)[C@@H]1CCC[NH+](C2CCN(CCc3ccccc3)CC2)C1.,CCN(CC)C(=O)[C@@H]1CCC[NH+](C2CCN(CCc3ccccc3)CC2)C1,benzene_ring
56703,Modify the molecule CN(Cc1cccs1)C(=O)c1cc(C2CC2)nn1-c1ccccc1 by removing a benzene_ring.,CN(Cc1cccs1)C(=O)c1cc(C2CC2)nn1-c1ccccc1,benzene_ring
244808,Modify the molecule COC(=O)c1ccc(C)c(OCC(=O)N(C2CCCC2)[C@@H]2CCS(=O)(=O)C2)c1 by removing a benzene_ring.,COC(=O)c1ccc(C)c(OCC(=O)N(C2CCCC2)[C@@H]2CCS(=O)(=O)C2)c1,benzene_ring
156009,Modify the molecule C[C@H]1CCC[NH+](CCNC(=O)c2ccc(C(F)(F)F)cc2[N+](=O)[O-])C1 by removing a halo.,C[C@H]1CCC[NH+](CCNC(=O)c2ccc(C(F)(F)F)cc2[N+](=O)[O-])C1,halo
97780,Modify the molecule CCN(CC)C(=O)c1ccc(Oc2snc(Cl)c2C#N)cc1 by removing a nitrile.,CCN(CC)C(=O)c1ccc(Oc2snc(Cl)c2C#N)cc1,nitrile
137060,Remove a amide from the molecule Cc1ccccc1OCC(=O)NNC(=O)[C@@H](C)N1C(=O)c2ccccc2C1=O.,Cc1ccccc1OCC(=O)NNC(=O)[C@@H](C)N1C(=O)c2ccccc2C1=O,amide
121388,Modify the molecule Cc1ccc(S(=O)(=O)N2CC[NH+](CC(=O)N/N=C\c3cccn3C)CC2)cc1 by removing a benzene_ring.,Cc1ccc(S(=O)(=O)N2CC[NH+](CC(=O)N/N=C\c3cccn3C)CC2)cc1,benzene_ring
168013,Please remove a benzene_ring from the molecule COc1cc(-c2noc([C@H]3CC(=O)N(c4ccc(C)c(F)c4)C3)n2)cc(OC)c1OC.,COc1cc(-c2noc([C@H]3CC(=O)N(c4ccc(C)c(F)c4)C3)n2)cc(OC)c1OC,benzene_ring
71457,Modify the molecule Cc1ncccc1C(=O)NCCCO by removing a hydroxyl.,Cc1ncccc1C(=O)NCCCO,hydroxyl
136712,Please remove a halo from the molecule CCC[C@H]1CN(Cc2ccc(CSC(F)F)o2)CCO1.,CCC[C@H]1CN(Cc2ccc(CSC(F)F)o2)CCO1,halo
171517,Please remove a halo from the molecule O=C(Nc1cccc(-c2noc(C3CCC3)n2)c1)Nc1ccc(F)c(Cl)c1.,O=C(Nc1cccc(-c2noc(C3CCC3)n2)c1)Nc1ccc(F)c(Cl)c1,halo
239206,Modify the molecule CCCNC(=O)CN(CCC)C(=O)c1cc(C)ccc1C by removing a benzene_ring.,CCCNC(=O)CN(CCC)C(=O)c1cc(C)ccc1C,benzene_ring
134140,Please remove a amine from the molecule [NH2+]=C(C1CC1)N1CC[NH+]2CCCC[C@H]2C1.,[NH2+]=C(C1CC1)N1CC[NH+]2CCCC[C@H]2C1,amine
69200,Remove a amide from the molecule C[C@H](C(=O)N(C)C1CCCCC1)[NH+]1CCC(C(=O)N2CCCCC2)CC1.,C[C@H](C(=O)N(C)C1CCCCC1)[NH+]1CCC(C(=O)N2CCCCC2)CC1,amide
117294,Modify the molecule O=C(Nc1ccc(Cl)nc1)c1ccc(Br)c(F)c1 by removing a benzene_ring.,O=C(Nc1ccc(Cl)nc1)c1ccc(Br)c(F)c1,benzene_ring
12694,Please remove a amine from the molecule O=S(=O)(NCc1nnc2c3ccccc3c(-c3ccc(Cl)cc3)nn12)c1ccc(F)cc1.,O=S(=O)(NCc1nnc2c3ccccc3c(-c3ccc(Cl)cc3)nn12)c1ccc(F)cc1,amine
207120,Please remove a halo from the molecule Cc1cccc(C(C)C)c1NC(=O)[C@H]1CC(=O)N(c2cc(F)cc(F)c2)C1.,Cc1cccc(C(C)C)c1NC(=O)[C@H]1CC(=O)N(c2cc(F)cc(F)c2)C1,halo
63388,Modify the molecule [NH3+]C1CCC(n2cc(C(=O)NCc3nc(C4CCCCC4)no3)nn2)CC1 by removing a amide.,[NH3+]C1CCC(n2cc(C(=O)NCc3nc(C4CCCCC4)no3)nn2)CC1,amide
219622,Remove a benzene_ring from the molecule Cc1nc(N2CCOCC2)cc(N2CCN(S(=O)(=O)c3ccc(F)cc3F)CC2)n1.,Cc1nc(N2CCOCC2)cc(N2CCN(S(=O)(=O)c3ccc(F)cc3F)CC2)n1,benzene_ring
38105,Modify the molecule Cc1n[nH]c(C(=O)Nc2ccccc2N2CCCC2)n1 by removing a benzene_ring.,Cc1n[nH]c(C(=O)Nc2ccccc2N2CCCC2)n1,benzene_ring
127268,Remove a amide from the molecule C[C@@H](NC(=O)C(=O)Nc1ccc(CC#N)cc1)c1ccc2c(c1)CCCC2.,C[C@@H](NC(=O)C(=O)Nc1ccc(CC#N)cc1)c1ccc2c(c1)CCCC2,amide
179949,Modify the molecule CSCC[C@@H](C)NC(=O)N1CCN(c2ncccc2C#N)CC1 by removing a nitrile.,CSCC[C@@H](C)NC(=O)N1CCN(c2ncccc2C#N)CC1,nitrile
154909,Remove a benzene_ring from the molecule O=C(CCS(=O)(=O)c1ccc2ccccc2c1)N1CCN(Cc2ccccc2F)CC1.,O=C(CCS(=O)(=O)c1ccc2ccccc2c1)N1CCN(Cc2ccccc2F)CC1,benzene_ring
134180,Remove a amide from the molecule CCn1cc[nH+]c1CN1CCN(CC(=O)NC(=O)NC2CC2)CC1.,CCn1cc[nH+]c1CN1CCN(CC(=O)NC(=O)NC2CC2)CC1,amide
148388,Modify the molecule Cc1ccc(N2C(=O)N[C@@H]3CCN(C(=O)CC4(CC(=O)[O-])CCCC4)[C@@H]3C2=O)cc1 by removing a benzene_ring.,Cc1ccc(N2C(=O)N[C@@H]3CCN(C(=O)CC4(CC(=O)[O-])CCCC4)[C@@H]3C2=O)cc1,benzene_ring
141609,Remove a halo from the molecule Cc1c(O)n[nH]c1C(=O)NN=Cc1ccc(Cl)cc1Cl.,Cc1c(O)n[nH]c1C(=O)NN=Cc1ccc(Cl)cc1Cl,halo
101320,Please remove a amide from the molecule O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccc(Cl)cc1)Nc1ccccc1.,O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccc(Cl)cc1)Nc1ccccc1,amide
138918,Please remove a halo from the molecule N#Cc1cccc([N-]S(=O)(=O)c2ccc(-c3cc(C(F)(F)F)n[nH]3)s2)c1.,N#Cc1cccc([N-]S(=O)(=O)c2ccc(-c3cc(C(F)(F)F)n[nH]3)s2)c1,halo
233423,Please remove a benzene_ring from the molecule COc1ccc(CCNC(=O)c2ccc(-c3nc4ccccc4n3C)s2)cc1OC.,COc1ccc(CCNC(=O)c2ccc(-c3nc4ccccc4n3C)s2)cc1OC,benzene_ring
14405,Remove a benzene_ring from the molecule CSCCn1cnc(-c2cccc([N+](=O)[O-])c2)n1.,CSCCn1cnc(-c2cccc([N+](=O)[O-])c2)n1,benzene_ring
17967,Modify the molecule Cc1ccc(-c2nnc(C[NH+]3CCC[C@H]3C[NH+]3CCC[C@@H]3CO)o2)cc1 by removing a hydroxyl.,Cc1ccc(-c2nnc(C[NH+]3CCC[C@H]3C[NH+]3CCC[C@@H]3CO)o2)cc1,hydroxyl
144588,Please remove a amide from the molecule Cc1c(C#N)c(NC(=O)CN2C[C@@H](C(N)=O)Oc3ccccc32)n(Cc2ccco2)c1C.,Cc1c(C#N)c(NC(=O)CN2C[C@@H](C(N)=O)Oc3ccccc32)n(Cc2ccco2)c1C,amide
22594,Remove a amide from the molecule Cc1cccc(O[C@@H](C)C(=O)N2CC[C@@H](C(=O)[O-])[C@@H]2C)c1.,Cc1cccc(O[C@@H](C)C(=O)N2CC[C@@H](C(=O)[O-])[C@@H]2C)c1,amide
29621,Modify the molecule CN1C(=O)C[C@H](NC(=O)NCc2cccc(C#N)c2)[C@@H]1c1ccc(Cl)cc1 by removing a benzene_ring.,CN1C(=O)C[C@H](NC(=O)NCc2cccc(C#N)c2)[C@@H]1c1ccc(Cl)cc1,benzene_ring
141561,Please remove a benzene_ring from the molecule CCN(Cc1ccccn1)c1ccc(F)cc1CC[NH3+].,CCN(Cc1ccccn1)c1ccc(F)cc1CC[NH3+],benzene_ring
129575,Remove a benzene_ring from the molecule COc1ccc([C@H]2NC([S-])=NC3=C2[NH+]2CCC3CC2)cc1.,COc1ccc([C@H]2NC([S-])=NC3=C2[NH+]2CCC3CC2)cc1,benzene_ring
186714,Remove a halo from the molecule CCc1cc(-c2ocnc2CCl)n(C)n1.,CCc1cc(-c2ocnc2CCl)n(C)n1,halo
83534,Modify the molecule CC[C@@H](C)c1ccc(S(=O)(=O)NC[C@@H]2CC[NH+](C3CC3)C2)cc1 by removing a benzene_ring.,CC[C@@H](C)c1ccc(S(=O)(=O)NC[C@@H]2CC[NH+](C3CC3)C2)cc1,benzene_ring
113995,Please remove a benzene_ring from the molecule CCc1ccccc1NCc1c(C(C)C)nn(C)c1N1CCOCC1.,CCc1ccccc1NCc1c(C(C)C)nn(C)c1N1CCOCC1,benzene_ring
123992,Modify the molecule CC[NH+](CC)[C@H]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)OCCO3)C1 by removing a amide.,CC[NH+](CC)[C@H]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)OCCO3)C1,amide
48960,Remove a amide from the molecule CC(C)c1nc(C(=O)Nc2ccc3c(c2)OCCO3)n[nH]1.,CC(C)c1nc(C(=O)Nc2ccc3c(c2)OCCO3)n[nH]1,amide
28910,Remove a halo from the molecule O=C(NCc1nncn1C1CC1)Nc1cccc(Cl)c1F.,O=C(NCc1nncn1C1CC1)Nc1cccc(Cl)c1F,halo
238904,Please remove a hydroxyl from the molecule CCCN(CCO)C(=O)N[C@H]1CCc2ccccc21.,CCCN(CCO)C(=O)N[C@H]1CCc2ccccc21,hydroxyl
212301,Remove a amide from the molecule Cc1cc(NC(=O)[C@H](C)SCc2cccc3c2OCCO3)on1.,Cc1cc(NC(=O)[C@H](C)SCc2cccc3c2OCCO3)on1,amide
101425,Remove a benzene_ring from the molecule CCOc1ccc(C2=CCN(C(=O)c3ccc(F)c(F)c3F)CC2)cc1.,CCOc1ccc(C2=CCN(C(=O)c3ccc(F)c(F)c3F)CC2)cc1,benzene_ring
85342,Please remove a halo from the molecule Cc1cc(NC(=O)CC(C)C)c(C)cc1I.,Cc1cc(NC(=O)CC(C)C)c(C)cc1I,halo
35114,Modify the molecule C/[NH+]=C(/NCc1cccc(F)c1)NCC(C)(C)N1C[C@H](C)O[C@H](C)C1 by removing a benzene_ring.,C/[NH+]=C(/NCc1cccc(F)c1)NCC(C)(C)N1C[C@H](C)O[C@H](C)C1,benzene_ring
83042,Modify the molecule CC(C)(C)NC(=O)c1cccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)c1 by removing a benzene_ring.,CC(C)(C)NC(=O)c1cccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)c1,benzene_ring
43220,Modify the molecule C=CCn1c([S-])nc2cc(C(=O)NCc3cccs3)ccc2c1=O by removing a amide.,C=CCn1c([S-])nc2cc(C(=O)NCc3cccs3)ccc2c1=O,amide
50038,Please remove a hydroxyl from the molecule CC(=O)N[C@@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)[O-].,CC(=O)N[C@@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)[O-],hydroxyl
144878,Modify the molecule C[C@@H]1CCN(C(=O)C(=O)Nc2ccnn2C(C)(C)C)C[C@H]1n1cc[nH+]c1 by removing a amide.,C[C@@H]1CCN(C(=O)C(=O)Nc2ccnn2C(C)(C)C)C[C@H]1n1cc[nH+]c1,amide
202932,Modify the molecule Cc1nc2c(-c3cccs3)c(C)nn2c(NCC[NH+](C)C)c1C by removing a amine.,Cc1nc2c(-c3cccs3)c(C)nn2c(NCC[NH+](C)C)c1C,amine
127024,Modify the molecule O=S(=O)(c1ccccc1F)N1CCN(CCn2cc[nH+]c2-c2ccccc2)CC1 by removing a benzene_ring.,O=S(=O)(c1ccccc1F)N1CCN(CCn2cc[nH+]c2-c2ccccc2)CC1,benzene_ring
125253,Remove a halo from the molecule CCOC(=O)CCC(=O)c1ccccc1Cl.,CCOC(=O)CCC(=O)c1ccccc1Cl,halo
59078,Remove a amide from the molecule C[C@H](C(N)=O)N1CCN(c2nccc(Oc3ccc(F)cc3)n2)CC1.,C[C@H](C(N)=O)N1CCN(c2nccc(Oc3ccc(F)cc3)n2)CC1,amide
182793,Modify the molecule O=C(NC[C@H]1CCCO1)[C@H]1CC(c2ccc(Cl)c(Cl)c2)=NO1 by removing a halo.,O=C(NC[C@H]1CCCO1)[C@H]1CC(c2ccc(Cl)c(Cl)c2)=NO1,halo
159495,Remove a amine from the molecule CC(C)(C)CC(C)(C)NC1=[NH+]CCN[C@H]1C(C)(C)C.,CC(C)(C)CC(C)(C)NC1=[NH+]CCN[C@H]1C(C)(C)C,amine
43340,Remove a benzene_ring from the molecule CO[C@@H](C(=O)NCc1n[nH]c(=S)n1C(C)C)c1ccccc1.,CO[C@@H](C(=O)NCc1n[nH]c(=S)n1C(C)C)c1ccccc1,benzene_ring
193497,Modify the molecule Cn1cccc1CN1CCc2c(Br)cccc2C1 by removing a halo.,Cn1cccc1CN1CCc2c(Br)cccc2C1,halo
195963,Modify the molecule Cn1cc[nH+]c1C[C@@H]1CCCN(C(=O)C(=O)Nc2cccnc2Cl)C1 by removing a halo.,Cn1cc[nH+]c1C[C@@H]1CCCN(C(=O)C(=O)Nc2cccnc2Cl)C1,halo
151264,Please remove a amide from the molecule Cn1c(CN2CCN(C(=O)C3CCCCC3)CC2)nc2cc(NC(=O)c3cccs3)ccc21.,Cn1c(CN2CCN(C(=O)C3CCCCC3)CC2)nc2cc(NC(=O)c3cccs3)ccc21,amide
177256,Please remove a amine from the molecule C/C(=N\N)c1cccc(O)c1.,C/C(=N\N)c1cccc(O)c1,amine
214575,Modify the molecule Cc1ccc(C)c(NC(=O)C(=O)NCC(C)(C)[C@@H](O)c2ccccc2)c1 by removing a hydroxyl.,Cc1ccc(C)c(NC(=O)C(=O)NCC(C)(C)[C@@H](O)c2ccccc2)c1,hydroxyl
185813,Remove a amide from the molecule COc1ccc(C(=O)Nc2ccc(CC(=O)N(C)C)cc2)nn1.,COc1ccc(C(=O)Nc2ccc(CC(=O)N(C)C)cc2)nn1,amide
198029,Modify the molecule Cc1noc(CCCNC(=O)N[C@@H](c2ccccc2)c2ccco2)n1 by removing a benzene_ring.,Cc1noc(CCCNC(=O)N[C@@H](c2ccccc2)c2ccco2)n1,benzene_ring
168007,Remove a benzene_ring from the molecule COc1ccccc1C[C@@H](C)N(C)C(=O)[C@H](C)NC(C)=O.,COc1ccccc1C[C@@H](C)N(C)C(=O)[C@H](C)NC(C)=O,benzene_ring
174889,Modify the molecule CSC[C@@](C)(O)CNC(=O)c1cc(-c2ccccc2)on1 by removing a amide.,CSC[C@@](C)(O)CNC(=O)c1cc(-c2ccccc2)on1,amide
134808,Please remove a halo from the molecule C[C@@H](CO)NC(=O)NC[C@H](C)Oc1ccc(F)cc1.,C[C@@H](CO)NC(=O)NC[C@H](C)Oc1ccc(F)cc1,halo
184467,Remove a benzene_ring from the molecule COc1cccc(-n2nnc(-c3nc(-c4ccccc4F)no3)c2C)c1.,COc1cccc(-n2nnc(-c3nc(-c4ccccc4F)no3)c2C)c1,benzene_ring
230342,Remove a amide from the molecule Cc1cc(C)cc(C(=O)N[C@@H](CCc2ccccc2)c2ccc3c(c2)OCCCO3)c1.,Cc1cc(C)cc(C(=O)N[C@@H](CCc2ccccc2)c2ccc3c(c2)OCCCO3)c1,amide
27014,Modify the molecule C[C@H](OC(=O)[C@H](C)N1C(=O)c2ccccc2C1=O)C(=O)c1ccc(F)c(F)c1 by removing a benzene_ring.,C[C@H](OC(=O)[C@H](C)N1C(=O)c2ccccc2C1=O)C(=O)c1ccc(F)c(F)c1,benzene_ring
103798,Remove a amide from the molecule CC(C)C(=O)Nc1c(-c2cccs2)nc2ccccn12.,CC(C)C(=O)Nc1c(-c2cccs2)nc2ccccn12,amide
151247,Please remove a halo from the molecule COc1ccc(Cl)c(NC(=O)c2csc(C#CCN)c2)c1.,COc1ccc(Cl)c(NC(=O)c2csc(C#CCN)c2)c1,halo
96067,Remove a halo from the molecule COc1cc(Br)c([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1OC.,COc1cc(Br)c([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1OC,halo
89904,Remove a amide from the molecule CCCCOc1ccc(C(=O)Nc2[nH]nc(C)c2N)cc1.,CCCCOc1ccc(C(=O)Nc2[nH]nc(C)c2N)cc1,amide
226968,Remove a benzene_ring from the molecule COC(=O)c1c(NC(=O)c2ccc(F)cc2)sc(C(=O)N[C@H](C)c2ccccc2)c1C.,COC(=O)c1c(NC(=O)c2ccc(F)cc2)sc(C(=O)N[C@H](C)c2ccccc2)c1C,benzene_ring
161024,Modify the molecule O=C([O-])[C@H]1CC(=O)N(CCN2C[C@H](C(=O)[O-])CC2=O)C1 by removing a amide.,O=C([O-])[C@H]1CC(=O)N(CCN2C[C@H](C(=O)[O-])CC2=O)C1,amide
190473,Remove a halo from the molecule CC(C)C[C@H](NC(N)=O)C(=O)N1CCc2ccc(Cl)cc2C1.,CC(C)C[C@H](NC(N)=O)C(=O)N1CCc2ccc(Cl)cc2C1,halo
47748,Please remove a amide from the molecule COc1ccc2nc(NC(=O)CN(C)S(=O)(=O)c3cccs3)sc2c1.,COc1ccc2nc(NC(=O)CN(C)S(=O)(=O)c3cccs3)sc2c1,amide
198441,Remove a benzene_ring from the molecule C/C(Cc1ccccc1)=N\NC(=O)CNC(=O)c1cccnc1.,C/C(Cc1ccccc1)=N\NC(=O)CNC(=O)c1cccnc1,benzene_ring
175739,Please remove a halo from the molecule CN(CCCN1CC[NH+](C)CC1)C(=O)C1(c2ccc(Cl)cc2)CC1.,CN(CCCN1CC[NH+](C)CC1)C(=O)C1(c2ccc(Cl)cc2)CC1,halo
135873,Please remove a benzene_ring from the molecule C[C@@H]1CCN(C(=O)COC/C=C/c2ccccc2)C[C@H]1O.,C[C@@H]1CCN(C(=O)COC/C=C/c2ccccc2)C[C@H]1O,benzene_ring
156041,Please remove a amine from the molecule Cc1cc(C)n(-c2ncnc(N3C[C@@]4(C)C[C@@H]3CC(C)(C)C4)c2N)n1.,Cc1cc(C)n(-c2ncnc(N3C[C@@]4(C)C[C@@H]3CC(C)(C)C4)c2N)n1,amine
222433,Please remove a benzene_ring from the molecule CCC12c3ccccc3C(c3ccccc31)[C@@H]1C(=O)N(c3cc(C(C)=O)ccc3OC)C(=O)[C@@H]12.,CCC12c3ccccc3C(c3ccccc31)[C@@H]1C(=O)N(c3cc(C(C)=O)ccc3OC)C(=O)[C@@H]12,benzene_ring
136751,Please remove a benzene_ring from the molecule COc1cc([C@H]2[NH2+]CCc3c2[nH]c2ccccc32)cc(OC)c1OC.,COc1cc([C@H]2[NH2+]CCc3c2[nH]c2ccccc32)cc(OC)c1OC,benzene_ring
165548,Please remove a benzene_ring from the molecule O=C(Oc1ccc(-n2cnnn2)cc1)c1cccc(N2CCCC2=O)c1.,O=C(Oc1ccc(-n2cnnn2)cc1)c1cccc(N2CCCC2=O)c1,benzene_ring
58020,Remove a halo from the molecule COc1ccc([C@H]([NH2+][C@@H](C)c2ccc(OC)cc2F)C2CCOCC2)cc1.,COc1ccc([C@H]([NH2+][C@@H](C)c2ccc(OC)cc2F)C2CCOCC2)cc1,halo
81235,Remove a amide from the molecule CC(C)[C@@H]1CN(C(=O)Cc2ccsc2)C[C@H]1C(=O)[O-].,CC(C)[C@@H]1CN(C(=O)Cc2ccsc2)C[C@H]1C(=O)[O-],amide
242442,Please remove a nitrile from the molecule CC(C)(CNC(=O)C(=O)Nc1nn(C(C)(C)C)cc1C#N)C1CCCC1.,CC(C)(CNC(=O)C(=O)Nc1nn(C(C)(C)C)cc1C#N)C1CCCC1,nitrile
144255,Please remove a amide from the molecule O=C(N/N=C/c1ccc(N2CCCCCC2)o1)c1cc2ccccc2o1.,O=C(N/N=C/c1ccc(N2CCCCCC2)o1)c1cc2ccccc2o1,amide
24665,Please remove a benzene_ring from the molecule Cc1cc(CN[C@@H](C)C#N)cc(C)c1F.,Cc1cc(CN[C@@H](C)C#N)cc(C)c1F,benzene_ring
116233,Remove a benzene_ring from the molecule C[C@@H](c1cccc(O)c1)[NH+](C)C[C@@H]1C[C@@H]1c1ccccc1.,C[C@@H](c1cccc(O)c1)[NH+](C)C[C@@H]1C[C@@H]1c1ccccc1,benzene_ring
115504,Please remove a amine from the molecule Cc1ccc(S(=O)(=O)NCCc2csc3nc(-c4cccs4)nn23)cc1C.,Cc1ccc(S(=O)(=O)NCCc2csc3nc(-c4cccs4)nn23)cc1C,amine
136296,Remove a amide from the molecule COCc1nnc(NC(=O)c2cc(=O)c(OCc3ccccc3)co2)s1.,COCc1nnc(NC(=O)c2cc(=O)c(OCc3ccccc3)co2)s1,amide
248870,Modify the molecule O=c1c(C[NH+]2CCN(c3ccccc3F)CC2)coc2ccc(Cl)cc12 by removing a benzene_ring.,O=c1c(C[NH+]2CCN(c3ccccc3F)CC2)coc2ccc(Cl)cc12,benzene_ring
137537,Modify the molecule CCn1c(=O)c(C(=O)NC(C)C)nc2cc(C)c(C)cc21 by removing a amide.,CCn1c(=O)c(C(=O)NC(C)C)nc2cc(C)c(C)cc21,amide
77662,Remove a nitro from the molecule O=C1OCC[C@H]1N1CCc2ccc([N+](=O)[O-])cc2C1.,O=C1OCC[C@H]1N1CCc2ccc([N+](=O)[O-])cc2C1,nitro
2030,Remove a amide from the molecule O=C(COc1ccccn1)NCc1ccc(F)cc1.,O=C(COc1ccccn1)NCc1ccc(F)cc1,amide
170322,Remove a benzene_ring from the molecule CN(CCC#N)C(=O)c1cnn(Cc2ccccc2)c1.,CN(CCC#N)C(=O)c1cnn(Cc2ccccc2)c1,benzene_ring
195330,Modify the molecule COc1ccc([C@H]2C(C(=O)Nc3ccccc3)=C(C)Nc3nnnn32)cc1 by removing a benzene_ring.,COc1ccc([C@H]2C(C(=O)Nc3ccccc3)=C(C)Nc3nnnn32)cc1,benzene_ring
6884,Please remove a benzene_ring from the molecule COc1c(NC(=O)Nc2cccc(NC(C)=O)c2C)c(C)nn1C.,COc1c(NC(=O)Nc2cccc(NC(C)=O)c2C)c(C)nn1C,benzene_ring
226995,Please remove a benzene_ring from the molecule Cc1ccccc1-n1ncc2c1CC(C)(C)C[C@@H]2[NH2+]Cc1ccc(C#CC(C)(C)O)cc1.,Cc1ccccc1-n1ncc2c1CC(C)(C)C[C@@H]2[NH2+]Cc1ccc(C#CC(C)(C)O)cc1,benzene_ring
44757,Remove a benzene_ring from the molecule Cc1ccc(S[C@H]2CCC[C@@]([NH3+])(CO)C2)c(C)c1.,Cc1ccc(S[C@H]2CCC[C@@]([NH3+])(CO)C2)c(C)c1,benzene_ring
202890,Please remove a amide from the molecule C[C@@H](NC(=O)c1ccccc1NC(=O)OCc1ccccc1)c1ccccc1.,C[C@@H](NC(=O)c1ccccc1NC(=O)OCc1ccccc1)c1ccccc1,amide
145203,Remove a hydroxyl from the molecule C[C@H]1COC[C@@H](C)N1C(=O)c1cc(Cl)c2ccccc2c1O.,C[C@H]1COC[C@@H](C)N1C(=O)c1cc(Cl)c2ccccc2c1O,hydroxyl
25039,Please remove a nitrile from the molecule CCc1ccccc1NC(=O)CSC1=C(C#N)[C@@H](c2ccc3c(c2)OCO3)[C@H]2C(=O)CCCC2=N1.,CCc1ccccc1NC(=O)CSC1=C(C#N)[C@@H](c2ccc3c(c2)OCO3)[C@H]2C(=O)CCCC2=N1,nitrile
2907,Remove a amine from the molecule CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1.,CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1,amine
120556,Remove a benzene_ring from the molecule O=C(c1cnns1)N1CCC[C@@H]1c1cccc(Br)c1.,O=C(c1cnns1)N1CCC[C@@H]1c1cccc(Br)c1,benzene_ring
197490,Remove a amide from the molecule Cc1[nH+]ccn1CCNC(=O)C1(Cc2cccc([C@H]3CCC[NH+](C)C3)c2)CCOCC1.,Cc1[nH+]ccn1CCNC(=O)C1(Cc2cccc([C@H]3CCC[NH+](C)C3)c2)CCOCC1,amide
103407,Remove a benzene_ring from the molecule Cc1cccc(C)c1NC(=O)CS[C@H](C)c1cc(F)ccc1F.,Cc1cccc(C)c1NC(=O)CS[C@H](C)c1cc(F)ccc1F,benzene_ring
60307,Remove a halo from the molecule C[C@@H](Cc1ccsc1)N(C)C(=O)NCc1ccc(Br)cc1.,C[C@@H](Cc1ccsc1)N(C)C(=O)NCc1ccc(Br)cc1,halo
6972,Remove a benzene_ring from the molecule C[C@@H]1C[NH+](CCOc2ccc(CC[NH3+])cc2)C[C@@H]1C.,C[C@@H]1C[NH+](CCOc2ccc(CC[NH3+])cc2)C[C@@H]1C,benzene_ring
33675,Please remove a amine from the molecule O=C(CS[C@H]1NN=C(c2cccs2)O1)C1=CC(C(=O)N2CCCC2)=NC1.,O=C(CS[C@H]1NN=C(c2cccs2)O1)C1=CC(C(=O)N2CCCC2)=NC1,amine
113655,Please remove a halo from the molecule O=C(NCc1ccnc(OCC(F)F)c1)NC1CCCCCC1.,O=C(NCc1ccnc(OCC(F)F)c1)NC1CCCCCC1,halo
105227,Remove a amide from the molecule CCOc1ccc(S(=O)(=O)N2CCC[C@@H](CNC(C)=O)C2)c2ccccc12.,CCOc1ccc(S(=O)(=O)N2CCC[C@@H](CNC(C)=O)C2)c2ccccc12,amide
147992,Remove a amide from the molecule Cc1cc(C(=O)NCC2CCN(S(=O)(=O)C3CC3)CC2)no1.,Cc1cc(C(=O)NCC2CCN(S(=O)(=O)C3CC3)CC2)no1,amide
41402,Remove a benzene_ring from the molecule COc1cccc(SCC(=O)Nc2ccc(C(=O)N(C)C)cc2)c1.,COc1cccc(SCC(=O)Nc2ccc(C(=O)N(C)C)cc2)c1,benzene_ring
40936,Modify the molecule COc1ncccc1CNC(=O)CCC1CCCC1 by removing a amide.,COc1ncccc1CNC(=O)CCC1CCCC1,amide
11086,Remove a amide from the molecule C#CCNC(=O)c1cc(OC)c(OC)cc1NC(=O)c1ccccc1.,C#CCNC(=O)c1cc(OC)c(OC)cc1NC(=O)c1ccccc1,amide
225146,Modify the molecule Cc1c(C(=O)Nc2ccc3c(c2)OCCO3)sc2ncn(Cc3ccccc3F)c(=O)c12 by removing a amide.,Cc1c(C(=O)Nc2ccc3c(c2)OCCO3)sc2ncn(Cc3ccccc3F)c(=O)c12,amide
141356,Remove a amide from the molecule C/C(=N\NC(=O)[C@H](C)Oc1ccc(Cl)cc1)c1ccccc1.,C/C(=N\NC(=O)[C@H](C)Oc1ccc(Cl)cc1)c1ccccc1,amide
176311,Remove a amide from the molecule COCC(=O)N(CCC(N)=O)c1ccccc1.,COCC(=O)N(CCC(N)=O)c1ccccc1,amide
186870,Remove a benzene_ring from the molecule C=CCn1/c(=N\C(=O)Cc2ccc(S(=O)(=O)CC)cc2)sc2cc3c(cc21)OCO3.,C=CCn1/c(=N\C(=O)Cc2ccc(S(=O)(=O)CC)cc2)sc2cc3c(cc21)OCO3,benzene_ring
152851,Remove a amide from the molecule COc1ccc2c(c1)[C@H]([NH2+]C[C@@H]1CCC(=O)N1)CCC2.,COc1ccc2c(c1)[C@H]([NH2+]C[C@@H]1CCC(=O)N1)CCC2,amide
169978,Modify the molecule CN(C(=O)NCc1cccc(OCc2ccccc2)c1)C1CCS(=O)CC1 by removing a benzene_ring.,CN(C(=O)NCc1cccc(OCc2ccccc2)c1)C1CCS(=O)CC1,benzene_ring
80021,Modify the molecule CC1(C)CN(C(=O)c2cccc(-n3cccn3)c2)CC[S@]1=O by removing a amide.,CC1(C)CN(C(=O)c2cccc(-n3cccn3)c2)CC[S@]1=O,amide
178182,Modify the molecule Cn1c(=C(C#N)C#N)s/c(=C/c2ccc(F)cc2)c1=O by removing a halo.,Cn1c(=C(C#N)C#N)s/c(=C/c2ccc(F)cc2)c1=O,halo
89380,Please remove a amide from the molecule O=C(CCNC(=O)N[C@@H]1CCCC[C@@H]1CO)NC1CCCC1.,O=C(CCNC(=O)N[C@@H]1CCCC[C@@H]1CO)NC1CCCC1,amide
200159,Modify the molecule N/C(=N/c1ccccc1)S[C@@H]1CC(=O)N(c2ccc(F)cc2)C1=O by removing a benzene_ring.,N/C(=N/c1ccccc1)S[C@@H]1CC(=O)N(c2ccc(F)cc2)C1=O,benzene_ring
22973,Remove a halo from the molecule Cn1cnc(Cl)c1Cl.,Cn1cnc(Cl)c1Cl,halo
90349,Modify the molecule CCOCCOc1cccc(C[NH2+]C)c1 by removing a benzene_ring.,CCOCCOc1cccc(C[NH2+]C)c1,benzene_ring
70812,Modify the molecule CC[NH+]1CC[C@H](N(C)CC(=O)NC(=O)Nc2ccc(C)c(C)c2)[C@H](C)C1 by removing a benzene_ring.,CC[NH+]1CC[C@H](N(C)CC(=O)NC(=O)Nc2ccc(C)c(C)c2)[C@H](C)C1,benzene_ring
22664,Please remove a benzene_ring from the molecule CCN(CC(C)(C)O)C(=O)Cc1ccc(C[NH3+])cc1.,CCN(CC(C)(C)O)C(=O)Cc1ccc(C[NH3+])cc1,benzene_ring
108102,Please remove a amide from the molecule Cc1csc(CN(C)C(=O)C=C2CCSCC2)n1.,Cc1csc(CN(C)C(=O)C=C2CCSCC2)n1,amide
188740,Remove a halo from the molecule O=C(c1ccc(Br)cc1F)c1ccccc1C[N+]1=CCCC1.,O=C(c1ccc(Br)cc1F)c1ccccc1C[N+]1=CCCC1,halo
112978,Please remove a benzene_ring from the molecule C[C@@H]([NH3+])c1cc(F)ccc1OC[C@@H]1Cc2ccccc2S1.,C[C@@H]([NH3+])c1cc(F)ccc1OC[C@@H]1Cc2ccccc2S1,benzene_ring
210784,Modify the molecule Cn1cc(C[NH+](C)Cc2ccccc2-c2ccccc2)c(=O)n(C)c1=O by removing a benzene_ring.,Cn1cc(C[NH+](C)Cc2ccccc2-c2ccccc2)c(=O)n(C)c1=O,benzene_ring
89410,Please remove a amide from the molecule CC(=O)N[C@@H](C(=O)O[C@H](C)c1nc(C)no1)C1CCCC1.,CC(=O)N[C@@H](C(=O)O[C@H](C)c1nc(C)no1)C1CCCC1,amide
198023,Modify the molecule Cc1ccc(NC(=O)NCCn2ncnn2)cc1 by removing a benzene_ring.,Cc1ccc(NC(=O)NCCn2ncnn2)cc1,benzene_ring
113570,Remove a amine from the molecule N#Cc1cnc(S[C@@H](C(=O)Nc2ccccc2)c2ccccc2)nc1N.,N#Cc1cnc(S[C@@H](C(=O)Nc2ccccc2)c2ccccc2)nc1N,amine
241793,Please remove a amide from the molecule CCc1nn(C)cc1NC(=O)c1cnc2onc(C)c2c1.,CCc1nn(C)cc1NC(=O)c1cnc2onc(C)c2c1,amide
63634,Modify the molecule C[C@@H](NC(=O)NC[C@@H]1CCO[C@@H]1C(C)(C)C)[C@H](C)c1ccccc1 by removing a benzene_ring.,C[C@@H](NC(=O)NC[C@@H]1CCO[C@@H]1C(C)(C)C)[C@H](C)c1ccccc1,benzene_ring
188777,Remove a benzene_ring from the molecule Cc1c(C(=O)OCc2cccc(Cl)c2)oc2ccccc12.,Cc1c(C(=O)OCc2cccc(Cl)c2)oc2ccccc12,benzene_ring
14535,Remove a amide from the molecule O=C(Nc1ccc(F)cc1)c1cccc(-n2cnnc2)n1.,O=C(Nc1ccc(F)cc1)c1cccc(-n2cnnc2)n1,amide
238638,Remove a benzene_ring from the molecule O=S1(=O)C[C@@H]2[C@@H](C1)N(c1cccc3ccccc13)C(=S)N2c1ccccc1.,O=S1(=O)C[C@@H]2[C@@H](C1)N(c1cccc3ccccc13)C(=S)N2c1ccccc1,benzene_ring
216966,Remove a benzene_ring from the molecule CCc1nn(C)c(C(=O)N/N=C/c2ccccc2)c1Cl.,CCc1nn(C)c(C(=O)N/N=C/c2ccccc2)c1Cl,benzene_ring
206095,Modify the molecule O[C@H](CN1CC[NH+](C/C=C/c2ccccc2)CC1)c1ccc(Cl)cc1 by removing a hydroxyl.,O[C@H](CN1CC[NH+](C/C=C/c2ccccc2)CC1)c1ccc(Cl)cc1,hydroxyl
31450,Modify the molecule CCN(c1ccccc1)S(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)cc2)cc1 by removing a benzene_ring.,CCN(c1ccccc1)S(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)cc2)cc1,benzene_ring
35177,Remove a amide from the molecule O=C(CC[C@@H]1NC(=O)NC1=O)NCc1cn2cc(Cl)ccc2n1.,O=C(CC[C@@H]1NC(=O)NC1=O)NCc1cn2cc(Cl)ccc2n1,amide
192837,Please remove a amide from the molecule CCCNC(=O)CNC(=O)c1cccs1.,CCCNC(=O)CNC(=O)c1cccs1,amide
158221,Please remove a benzene_ring from the molecule C[C@H]([NH2+]Cc1ccc(-n2ccnc2)cc1)c1ccco1.,C[C@H]([NH2+]Cc1ccc(-n2ccnc2)cc1)c1ccco1,benzene_ring
110935,Modify the molecule Cc1nc2cc(NS(=O)(=O)c3cccc(C#N)c3)ccc2o1 by removing a benzene_ring.,Cc1nc2cc(NS(=O)(=O)c3cccc(C#N)c3)ccc2o1,benzene_ring
36403,Modify the molecule CC[C@H](C)CNS(=O)(=O)c1cc([N+](=O)[O-])c(F)cc1C by removing a nitro.,CC[C@H](C)CNS(=O)(=O)c1cc([N+](=O)[O-])c(F)cc1C,nitro
107663,Please remove a amide from the molecule NC(=O)NCc1ccc(C(=O)N(CC2CC2)c2ccccc2)cc1.,NC(=O)NCc1ccc(C(=O)N(CC2CC2)c2ccccc2)cc1,amide
243485,Remove a amide from the molecule O=C(NCc1ccccn1)[C@@H]1CCCN1C(=O)C12CC3CC(CC(C3)C1)C2.,O=C(NCc1ccccn1)[C@@H]1CCCN1C(=O)C12CC3CC(CC(C3)C1)C2,amide
234268,Remove a amide from the molecule CC(C)CNc1nc2ccccn2c(=O)c1/C=C1\SC(=S)N(C[C@H]2CCCO2)C1=O.,CC(C)CNc1nc2ccccn2c(=O)c1/C=C1\SC(=S)N(C[C@H]2CCCO2)C1=O,amide
143595,Please remove a amide from the molecule C[C@H](c1ccccc1)N1C[C@@H](c2nc3ccccc3n2CC(=O)N2CCOCC2)CC1=O.,C[C@H](c1ccccc1)N1C[C@@H](c2nc3ccccc3n2CC(=O)N2CCOCC2)CC1=O,amide
119866,Remove a amide from the molecule NC(=O)CCCOC(=O)c1ccc(F)c(Br)c1.,NC(=O)CCCOC(=O)c1ccc(F)c(Br)c1,amide
161939,Modify the molecule Cc1cc(C)cc(Nc2nc(C)cc3nn(CC(=O)NCc4ccco4)c(=O)n23)c1 by removing a benzene_ring.,Cc1cc(C)cc(Nc2nc(C)cc3nn(CC(=O)NCc4ccco4)c(=O)n23)c1,benzene_ring
12215,Remove a halo from the molecule COC(=O)C[C@H](C)S[C@H]1CCN(c2c(F)cccc2F)C1=O.,COC(=O)C[C@H](C)S[C@H]1CCN(c2c(F)cccc2F)C1=O,halo
229805,Modify the molecule COc1ccccc1CNC(=O)[C@H](C)Sc1nnc(-c2c[nH]c3ccccc23)o1 by removing a benzene_ring.,COc1ccccc1CNC(=O)[C@H](C)Sc1nnc(-c2c[nH]c3ccccc23)o1,benzene_ring
145517,Please remove a benzene_ring from the molecule Cc1ccccc1-c1c(C2C(C)(C)C2(C)C)noc1N.,Cc1ccccc1-c1c(C2C(C)(C)C2(C)C)noc1N,benzene_ring
132169,Remove a benzene_ring from the molecule O=C(Nc1ccc(-c2ncon2)cc1)c1cccc(Br)n1.,O=C(Nc1ccc(-c2ncon2)cc1)c1cccc(Br)n1,benzene_ring
137146,Modify the molecule O=C(/C=C/c1ccc2c(c1)CCO2)N1CCC[C@@H]1c1nnc2ccccn12 by removing a amide.,O=C(/C=C/c1ccc2c(c1)CCO2)N1CCC[C@@H]1c1nnc2ccccn12,amide
128950,Remove a amine from the molecule CCc1ccc([C@H](C)NC(=O)CSc2nnc(-n3nc(C)cc3C)n2N)cc1.,CCc1ccc([C@H](C)NC(=O)CSc2nnc(-n3nc(C)cc3C)n2N)cc1,amine
136008,Please remove a amide from the molecule CCCC(=O)N1CSC[C@H]1C(=O)N[C@@H](CC)c1c(C)nn(C)c1C.,CCCC(=O)N1CSC[C@H]1C(=O)N[C@@H](CC)c1c(C)nn(C)c1C,amide
157647,Modify the molecule Cc1ccc(NC(=O)[C@H](C)Sc2ncn[nH]2)c(C)c1 by removing a amide.,Cc1ccc(NC(=O)[C@H](C)Sc2ncn[nH]2)c(C)c1,amide
70839,Please remove a amine from the molecule C[C@H](Nc1nc2nonc2nc1NCc1ccccc1)c1nccs1.,C[C@H](Nc1nc2nonc2nc1NCc1ccccc1)c1nccs1,amine
192971,Modify the molecule COc1cc(C)c(N)cc1S(=O)(=O)N[C@H](C)CCC(C)C by removing a benzene_ring.,COc1cc(C)c(N)cc1S(=O)(=O)N[C@H](C)CCC(C)C,benzene_ring
102826,Modify the molecule CCC[NH2+][C@@H](COC)C1(c2ccccc2)CCCC1 by removing a benzene_ring.,CCC[NH2+][C@@H](COC)C1(c2ccccc2)CCCC1,benzene_ring
116941,Remove a nitrile from the molecule COC(=O)CN(CC#N)S(=O)(=O)c1cc(C)c(C)s1.,COC(=O)CN(CC#N)S(=O)(=O)c1cc(C)c(C)s1,nitrile
166967,Modify the molecule CC[C@](C)(NS(=O)(=O)c1ccc(OC)c(F)c1)C(=O)[O-] by removing a amine.,CC[C@](C)(NS(=O)(=O)c1ccc(OC)c(F)c1)C(=O)[O-],amine
123568,Modify the molecule COC(=O)CCN(CC(C)C)C(=O)c1ccc(Cl)nc1Cl by removing a amide.,COC(=O)CCN(CC(C)C)C(=O)c1ccc(Cl)nc1Cl,amide
176440,Remove a amide from the molecule C[C@@H](C(=O)N[C@H](CC(N)=O)C1CCCCC1)n1nnc(-c2ccccc2)n1.,C[C@@H](C(=O)N[C@H](CC(N)=O)C1CCCCC1)n1nnc(-c2ccccc2)n1,amide
45324,Please remove a benzene_ring from the molecule N#CCC(=O)c1ccc(F)cc1F.,N#CCC(=O)c1ccc(F)cc1F,benzene_ring
29489,Remove a benzene_ring from the molecule CN(C)[C@@H]1CCC[NH+](C[C@@H]2C[C@@H]2c2ccccc2)C1.,CN(C)[C@@H]1CCC[NH+](C[C@@H]2C[C@@H]2c2ccccc2)C1,benzene_ring
216602,Modify the molecule CC(=C/c1ccccc1)/C=C1/N=C(c2cccc([N+](=O)[O-])c2)OC1=O by removing a benzene_ring.,CC(=C/c1ccccc1)/C=C1/N=C(c2cccc([N+](=O)[O-])c2)OC1=O,benzene_ring
106068,Remove a benzene_ring from the molecule CC[NH+](CC)CCNC(=O)N(C)Cc1ccccc1C.,CC[NH+](CC)CCNC(=O)N(C)Cc1ccccc1C,benzene_ring
153151,Remove a amine from the molecule Cc1noc(C)c1S(=O)(=O)NCCn1nc(-n2ccnc2)ccc1=O.,Cc1noc(C)c1S(=O)(=O)NCCn1nc(-n2ccnc2)ccc1=O,amine
78104,Please remove a amide from the molecule C=CCNC(=O)NC(=O)[C@H](C)N1CC[NH+](CC2CC2)CC1.,C=CCNC(=O)NC(=O)[C@H](C)N1CC[NH+](CC2CC2)CC1,amide
43647,Modify the molecule CCc1ccc([C@H](CO)NC(=O)[C@H]2CCCN2C(C)=O)cc1 by removing a benzene_ring.,CCc1ccc([C@H](CO)NC(=O)[C@H]2CCCN2C(C)=O)cc1,benzene_ring
63925,Modify the molecule C[C@](Nc1ncc([N+](=O)[O-])cc1Br)(C(=O)[O-])C1CC1 by removing a nitro.,C[C@](Nc1ncc([N+](=O)[O-])cc1Br)(C(=O)[O-])C1CC1,nitro
94272,Please remove a benzene_ring from the molecule CC(C)(C)c1ccc(C(=O)N2CCN(c3c(Cl)cccc3NC(N)=S)CC2)cc1.,CC(C)(C)c1ccc(C(=O)N2CCN(c3c(Cl)cccc3NC(N)=S)CC2)cc1,benzene_ring
110774,Modify the molecule CCc1nn(C)cc1C(=O)N[C@@H](CC)c1ccccc1O by removing a amide.,CCc1nn(C)cc1C(=O)N[C@@H](CC)c1ccccc1O,amide
40867,Modify the molecule O=C(CCSc1ccccc1)N1CCC[C@@H](c2nnc3ccc(C(F)(F)F)cn23)C1 by removing a amide.,O=C(CCSc1ccccc1)N1CCC[C@@H](c2nnc3ccc(C(F)(F)F)cn23)C1,amide
248001,Please remove a amide from the molecule Cc1cccc(C(=O)NCCn2nc(-c3cccnc3)ccc2=O)c1.,Cc1cccc(C(=O)NCCn2nc(-c3cccnc3)ccc2=O)c1,amide
213838,Modify the molecule CC[C@H](c1ccc(F)cc1F)[NH+]1CCC[C@H](C(=O)Nc2ncccc2C)C1 by removing a amide.,CC[C@H](c1ccc(F)cc1F)[NH+]1CCC[C@H](C(=O)Nc2ncccc2C)C1,amide
84817,Remove a halo from the molecule O=C(CSc1nnc(NC(=O)c2ccccc2)s1)NCc1ccc(F)cc1.,O=C(CSc1nnc(NC(=O)c2ccccc2)s1)NCc1ccc(F)cc1,halo
106308,Modify the molecule CCc1noc(CC)c1CC(=O)Nc1ncc(C)s1 by removing a amide.,CCc1noc(CC)c1CC(=O)Nc1ncc(C)s1,amide
170332,Modify the molecule O=[N+]([O-])c1ccc(CSc2nc(-c3ccccc3)c[nH]2)cc1 by removing a benzene_ring.,O=[N+]([O-])c1ccc(CSc2nc(-c3ccccc3)c[nH]2)cc1,benzene_ring
128122,Remove a halo from the molecule CC1(C)[C@@H](NC(=O)c2ccc(Cl)c3cccnc23)[C@@H]2CCO[C@@H]21.,CC1(C)[C@@H](NC(=O)c2ccc(Cl)c3cccnc23)[C@@H]2CCO[C@@H]21,halo
121901,Modify the molecule COc1ccc2c(CN3CCN(C(=O)[C@@H]4C[C@@H]4C)CC3)cc(=O)oc2c1 by removing a amide.,COc1ccc2c(CN3CCN(C(=O)[C@@H]4C[C@@H]4C)CC3)cc(=O)oc2c1,amide
177098,Please remove a amide from the molecule CC(C)N(C)C(=O)[C@H](C)SCc1ccnn1C.,CC(C)N(C)C(=O)[C@H](C)SCc1ccnn1C,amide
146119,Remove a amide from the molecule CC(C)(C)OC(=O)N1CCC[C@H]1CCC(=O)NNc1cccnc1Cl.,CC(C)(C)OC(=O)N1CCC[C@H]1CCC(=O)NNc1cccnc1Cl,amide
192843,Please remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)N[C@H](C)C(C)C.,Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)N[C@H](C)C(C)C,benzene_ring
63840,Please remove a benzene_ring from the molecule CNC(=O)[C@H](CC(C)C)NS(=O)(=O)c1ccc(F)cc1C.,CNC(=O)[C@H](CC(C)C)NS(=O)(=O)c1ccc(F)cc1C,benzene_ring
10942,Please remove a amide from the molecule CC1(C)C(=O)NC(=O)CN1Cc1cccc(N)[nH+]1.,CC1(C)C(=O)NC(=O)CN1Cc1cccc(N)[nH+]1,amide
138562,Modify the molecule Cc1cc(Oc2ccc(C#N)cc2)ccc1NC(=O)N1CCc2ccccc2C1 by removing a benzene_ring.,Cc1cc(Oc2ccc(C#N)cc2)ccc1NC(=O)N1CCc2ccccc2C1,benzene_ring
244054,Modify the molecule Cc1ccc(C(C)C)c(OCC(=O)Nc2nc(C[NH+]3CCCCC3)cs2)c1 by removing a benzene_ring.,Cc1ccc(C(C)C)c(OCC(=O)Nc2nc(C[NH+]3CCCCC3)cs2)c1,benzene_ring
200932,Modify the molecule Cc1nn(CC(=O)N[C@H]2C[C@@H]2c2cccc(F)c2)c(C)c1[N+](=O)[O-] by removing a benzene_ring.,Cc1nn(CC(=O)N[C@H]2C[C@@H]2c2cccc(F)c2)c(C)c1[N+](=O)[O-],benzene_ring
99992,Modify the molecule Cc1ccc(SCC(=O)c2cc(C)n([C@@H]3CCS(=O)(=O)C3)c2C)c(C)c1 by removing a benzene_ring.,Cc1ccc(SCC(=O)c2cc(C)n([C@@H]3CCS(=O)(=O)C3)c2C)c(C)c1,benzene_ring
14083,Modify the molecule OCCCC[C@@H]1Nc2ccc(F)cc2[C@H]2OCCC[C@@H]12 by removing a hydroxyl.,OCCCC[C@@H]1Nc2ccc(F)cc2[C@H]2OCCC[C@@H]12,hydroxyl
105294,Remove a benzene_ring from the molecule CC[C@@](C)([C@H](O)c1ccccc1)[NH+](C)C.,CC[C@@](C)([C@H](O)c1ccccc1)[NH+](C)C,benzene_ring
73528,Please remove a amide from the molecule N#CCCCn1ccc(NC(=O)Cc2cccs2)n1.,N#CCCCn1ccc(NC(=O)Cc2cccs2)n1,amide
140964,Remove a amide from the molecule C=CCN(C(=O)[C@@H](C[NH3+])CC(C)C)C(C)C.,C=CCN(C(=O)[C@@H](C[NH3+])CC(C)C)C(C)C,amide
184741,Remove a amide from the molecule O=C(N/N=C/c1ccco1)c1ccc2[nH]cnc2c1.,O=C(N/N=C/c1ccco1)c1ccc2[nH]cnc2c1,amide
165063,Remove a benzene_ring from the molecule O=S(=O)(c1cn[nH]c1)N1CCC[C@H](c2cccc(-c3cccc(F)c3)n2)C1.,O=S(=O)(c1cn[nH]c1)N1CCC[C@H](c2cccc(-c3cccc(F)c3)n2)C1,benzene_ring
32242,Modify the molecule CCN1CCN(c2nc(NC[C@@H]3CCCO3)c3ccccc3[nH+]2)CC1 by removing a amine.,CCN1CCN(c2nc(NC[C@@H]3CCCO3)c3ccccc3[nH+]2)CC1,amine
60509,Modify the molecule C[C@@H](NC(=O)N(C1CC1)[C@H](C)C1CC1)c1ccc(-c2ccncc2)cc1 by removing a benzene_ring.,C[C@@H](NC(=O)N(C1CC1)[C@H](C)C1CC1)c1ccc(-c2ccncc2)cc1,benzene_ring
64813,Please remove a amide from the molecule CCC[C@@H](C)NC(=O)[C@H](C)C[NH2+]C.,CCC[C@@H](C)NC(=O)[C@H](C)C[NH2+]C,amide
39954,Please remove a amide from the molecule COc1cc(C(=O)OCC(=O)Nc2cccc(C(C)=O)c2)ccc1C.,COc1cc(C(=O)OCC(=O)Nc2cccc(C(C)=O)c2)ccc1C,amide
97204,Please remove a amine from the molecule CCC[C@@]1(C)C[NH+]=C(N)N1c1ccccc1.,CCC[C@@]1(C)C[NH+]=C(N)N1c1ccccc1,amine
58745,Remove a halo from the molecule COC(=O)C[C@@H](C)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1.,COC(=O)C[C@@H](C)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1,halo
246768,Please remove a amide from the molecule CC(C)[C@H]1C[NH+](Cc2ccco2)CCN1C(=O)c1ccc(Cn2cccn2)o1.,CC(C)[C@H]1C[NH+](Cc2ccco2)CCN1C(=O)c1ccc(Cn2cccn2)o1,amide
95523,Remove a halo from the molecule CN(C)c1c(Cl)cccc1NC(=O)CCCCO.,CN(C)c1c(Cl)cccc1NC(=O)CCCCO,halo
203730,Remove a amide from the molecule O=C(COC(=O)Cn1nc([O-])c2ccccc2c1=O)Nc1c(Cl)cccc1C(F)(F)F.,O=C(COC(=O)Cn1nc([O-])c2ccccc2c1=O)Nc1c(Cl)cccc1C(F)(F)F,amide
179551,Modify the molecule O=C(NCc1cccc(C(=O)NC[C@H]2CCCO2)c1)Nc1ccc(F)c(F)c1 by removing a halo.,O=C(NCc1cccc(C(=O)NC[C@H]2CCCO2)c1)Nc1ccc(F)c(F)c1,halo
178734,Please remove a amide from the molecule COc1ccc(C(=O)N2CCC(c3cc(=O)cc(C)[nH]3)CC2)cn1.,COc1ccc(C(=O)N2CCC(c3cc(=O)cc(C)[nH]3)CC2)cn1,amide
94345,Remove a amide from the molecule Cc1ccccc1[C@H](C#N)NC(=O)[C@H]1CC(=O)N(C(C)C)C1.,Cc1ccccc1[C@H](C#N)NC(=O)[C@H]1CC(=O)N(C(C)C)C1,amide
105741,Please remove a amide from the molecule Cn1c(SCC(=O)N2CCCCCC2)nnc1-c1cccnc1.,Cn1c(SCC(=O)N2CCCCCC2)nnc1-c1cccnc1,amide
24590,Remove a amide from the molecule COC(=O)[C@H]1C[C@H]2CCCC[C@H]2N1C(=O)c1ccc(-c2nc(C)no2)cc1.,COC(=O)[C@H]1C[C@H]2CCCC[C@H]2N1C(=O)c1ccc(-c2nc(C)no2)cc1,amide
1400,Modify the molecule C=CCSc1nc(N)c(C#N)cc1C#N by removing a amine.,C=CCSc1nc(N)c(C#N)cc1C#N,amine
114282,Remove a halo from the molecule O=C1N[C@H](c2ccc(F)cc2)C(C(=O)c2cccs2)=C1O.,O=C1N[C@H](c2ccc(F)cc2)C(C(=O)c2cccs2)=C1O,halo
180107,Please remove a halo from the molecule COC[C@@H](C)n1c(CCCl)nc2cc(C)cnc21.,COC[C@@H](C)n1c(CCCl)nc2cc(C)cnc21,halo
2634,Remove a amide from the molecule CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21.,CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21,amide
56894,Remove a nitro from the molecule CCNc1nnc(Sc2ccc(C(=O)NC3CC3)cc2[N+](=O)[O-])s1.,CCNc1nnc(Sc2ccc(C(=O)NC3CC3)cc2[N+](=O)[O-])s1,nitro
206477,Please remove a halo from the molecule Cc1c([C@@H](C)NC(=O)CCc2nc3ccccc3s2)cnn1-c1ccc(F)cc1.,Cc1c([C@@H](C)NC(=O)CCc2nc3ccccc3s2)cnn1-c1ccc(F)cc1,halo
8807,Please remove a benzene_ring from the molecule CCO[C@@H](C)c1nc(CNc2cccc(-n3nnnc3C)c2)cs1.,CCO[C@@H](C)c1nc(CNc2cccc(-n3nnnc3C)c2)cs1,benzene_ring
162253,Modify the molecule CC(=O)C[C@H]1CCCCCN1C(=O)[C@@H]1CCS(=O)(=O)C1 by removing a amide.,CC(=O)C[C@H]1CCCCCN1C(=O)[C@@H]1CCS(=O)(=O)C1,amide
194066,Modify the molecule CCc1nnc2ccc(S(=O)(=O)N(CC)c3ccccc3)cn12 by removing a benzene_ring.,CCc1nnc2ccc(S(=O)(=O)N(CC)c3ccccc3)cn12,benzene_ring
229620,Please remove a amide from the molecule COc1ccc(N2C(=O)C(c3c(C(C)C)nn(-c4ccccc4)c3O)=C([n+]3ccccc3)C2=O)cc1.,COc1ccc(N2C(=O)C(c3c(C(C)C)nn(-c4ccccc4)c3O)=C([n+]3ccccc3)C2=O)cc1,amide
43403,Modify the molecule Cc1ccc(C)c(C(=O)NC[C@H](O)Cc2ccccc2)c1 by removing a benzene_ring.,Cc1ccc(C)c(C(=O)NC[C@H](O)Cc2ccccc2)c1,benzene_ring
98493,Modify the molecule CCc1ccc(CC)c(NC(=O)CC2CN(C(=O)OC(C)(C)C)C2)c1 by removing a amide.,CCc1ccc(CC)c(NC(=O)CC2CN(C(=O)OC(C)(C)C)C2)c1,amide
171576,Modify the molecule CC(=O)NCC(=O)NCC(=O)N1C[C@H](c2ccc(F)cc2)C[C@@H]1C by removing a halo.,CC(=O)NCC(=O)NCC(=O)N1C[C@H](c2ccc(F)cc2)C[C@@H]1C,halo
205052,Remove a nitrile from the molecule CCCn1cc(CC)cc1C#N.,CCCn1cc(CC)cc1C#N,nitrile
7361,Please remove a benzene_ring from the molecule Cc1ccccc1N1CCN(Cc2cn3ccccc3[nH+]2)CC1.,Cc1ccccc1N1CCN(Cc2cn3ccccc3[nH+]2)CC1,benzene_ring
13373,Modify the molecule O=c1[nH]c(CSc2nncs2)nc2ccc(Cl)cc12 by removing a halo.,O=c1[nH]c(CSc2nncs2)nc2ccc(Cl)cc12,halo
59309,Remove a benzene_ring from the molecule CC[C@@](C)([NH3+])C(=O)Nc1cc(C(=O)[O-])cc(C(F)(F)F)c1.,CC[C@@](C)([NH3+])C(=O)Nc1cc(C(=O)[O-])cc(C(F)(F)F)c1,benzene_ring
197568,Please remove a amine from the molecule COCC(=O)N1CC[C@@H](c2nc(C)cc(Nc3nc(C)cc(C)n3)n2)C1.,COCC(=O)N1CC[C@@H](c2nc(C)cc(Nc3nc(C)cc(C)n3)n2)C1,amine
41302,Modify the molecule Cn1cc(NC(=O)c2cccc(CN3CCN(c4cnccn4)CC3)c2)cn1 by removing a benzene_ring.,Cn1cc(NC(=O)c2cccc(CN3CCN(c4cnccn4)CC3)c2)cn1,benzene_ring
100042,Remove a halo from the molecule C[C@H]1C[C@@H](N2CCC[C@H](C(=O)Nc3ccc(Cl)cn3)C2)C(=O)O1.,C[C@H]1C[C@@H](N2CCC[C@H](C(=O)Nc3ccc(Cl)cn3)C2)C(=O)O1,halo
111923,Please remove a benzene_ring from the molecule CCN(CC(C)(C)CS)c1ccccc1.,CCN(CC(C)(C)CS)c1ccccc1,benzene_ring
147868,Remove a nitrile from the molecule N#C[C@H](c1ccccc1)N1CCN(Cc2csc(-c3ccoc3)n2)CC1.,N#C[C@H](c1ccccc1)N1CCN(Cc2csc(-c3ccoc3)n2)CC1,nitrile
15238,Remove a amine from the molecule Cc1ccccc1C[NH+]1CCC(CN(C[C@H]2CCCO2)C(=O)[C@H]2C=c3ccccc3=[NH+]2)CC1.,Cc1ccccc1C[NH+]1CCC(CN(C[C@H]2CCCO2)C(=O)[C@H]2C=c3ccccc3=[NH+]2)CC1,amine
104879,Modify the molecule CCCN[C@@]1(C#N)CC[C@H](SC2CCCCC2)C1 by removing a amine.,CCCN[C@@]1(C#N)CC[C@H](SC2CCCCC2)C1,amine
146645,Remove a amide from the molecule O=C(CN1CCCOC1=O)NCc1nccc2ccccc12.,O=C(CN1CCCOC1=O)NCc1nccc2ccccc12,amide
121200,Modify the molecule Cc1ccc(S(=O)(=O)N2CCOCC2)cc1C(=O)N1C[C@@H](C)C[C@@H](C)C1 by removing a benzene_ring.,Cc1ccc(S(=O)(=O)N2CCOCC2)cc1C(=O)N1C[C@@H](C)C[C@@H](C)C1,benzene_ring
192909,Remove a amide from the molecule CN1CCN(C(=O)[C@H]2C[C@H]3CC[C@@H]2[NH2+]3)C(C)(C)C1=O.,CN1CCN(C(=O)[C@H]2C[C@H]3CC[C@@H]2[NH2+]3)C(C)(C)C1=O,amide
137835,Modify the molecule Cc1ccc2[nH]c(=S)n([C@H]3CCC(=O)NC3)c2c1 by removing a amide.,Cc1ccc2[nH]c(=S)n([C@H]3CCC(=O)NC3)c2c1,amide
191292,Please remove a benzene_ring from the molecule c1ncn(-c2ccc(N[C@@H]3CC[NH2+]C3)cc2)n1.,c1ncn(-c2ccc(N[C@@H]3CC[NH2+]C3)cc2)n1,benzene_ring
93581,Please remove a nitro from the molecule CC[C@H]1CN(C(=O)Cn2cc([N+](=O)[O-])ccc2=O)CC[C@@H]1c1ccccc1.,CC[C@H]1CN(C(=O)Cn2cc([N+](=O)[O-])ccc2=O)CC[C@@H]1c1ccccc1,nitro
112857,Please remove a amide from the molecule CNC(=O)[C@@H]1C[C@H]([NH3+])CN1C(=O)c1ccc(C(F)(F)F)nc1[O-].,CNC(=O)[C@@H]1C[C@H]([NH3+])CN1C(=O)c1ccc(C(F)(F)F)nc1[O-],amide
166977,Remove a amine from the molecule FC(F)Oc1ccc(Br)cc1CNC[C@@H]1COc2ccccc2O1.,FC(F)Oc1ccc(Br)cc1CNC[C@@H]1COc2ccccc2O1,amine
54472,Modify the molecule C[C@H]([NH2+]Cc1cnc(N2CCOCC2)nc1)c1ccc(F)c(F)c1 by removing a benzene_ring.,C[C@H]([NH2+]Cc1cnc(N2CCOCC2)nc1)c1ccc(F)c(F)c1,benzene_ring
36896,Remove a benzene_ring from the molecule C[C@@H]1C[C@@H](NC(=O)Nc2ccccn2)CC[NH+]1Cc1ccccc1.,C[C@@H]1C[C@@H](NC(=O)Nc2ccccn2)CC[NH+]1Cc1ccccc1,benzene_ring
136721,Modify the molecule CCOc1cc(C(=O)[O-])c(NC(=O)c2ccccc2OC)cc1OC by removing a benzene_ring.,CCOc1cc(C(=O)[O-])c(NC(=O)c2ccccc2OC)cc1OC,benzene_ring
211588,Remove a benzene_ring from the molecule Cc1ccccc1N1C(=O)/C(=C/c2cc(Cl)cc(Cl)c2OS(C)(=O)=O)SC1=S.,Cc1ccccc1N1C(=O)/C(=C/c2cc(Cl)cc(Cl)c2OS(C)(=O)=O)SC1=S,benzene_ring
110288,Please remove a benzene_ring from the molecule Cc1nc(N(C)CC[C@H](O)c2ccccc2)c2c(C)nn(C)c2n1.,Cc1nc(N(C)CC[C@H](O)c2ccccc2)c2c(C)nn(C)c2n1,benzene_ring
108201,Please remove a amide from the molecule O=C(Cc1cccc([N+](=O)[O-])c1)N1CCC[C@H]1C[C@@H](O)c1ccco1.,O=C(Cc1cccc([N+](=O)[O-])c1)N1CCC[C@H]1C[C@@H](O)c1ccco1,amide
221147,Modify the molecule Cc1cc(C)cc(NS(=O)(=O)c2ccc(N3CCOC3=O)cc2)c1 by removing a benzene_ring.,Cc1cc(C)cc(NS(=O)(=O)c2ccc(N3CCOC3=O)cc2)c1,benzene_ring
86357,Modify the molecule C[C@H](CC(=O)N1CCC([C@@H]2Nc3ccccc3S(=O)(=O)N2)CC1)n1cncn1 by removing a amine.,C[C@H](CC(=O)N1CCC([C@@H]2Nc3ccccc3S(=O)(=O)N2)CC1)n1cncn1,amine
137711,Modify the molecule COC(=O)[C@](C)(NCc1ccon1)C1CC1 by removing a amine.,COC(=O)[C@](C)(NCc1ccon1)C1CC1,amine
7273,Please remove a halo from the molecule C[C@@H](C(=O)N1CC[C@@H](Oc2ccc(C(F)(F)F)cn2)C1)n1cncn1.,C[C@@H](C(=O)N1CC[C@@H](Oc2ccc(C(F)(F)F)cn2)C1)n1cncn1,halo
188618,Please remove a benzene_ring from the molecule O=C([O-])c1ccc(S(=O)(=O)[O-])cc1N1C(=O)/C(=C\C=C\c2ccccc2)N=C1c1ccccc1.,O=C([O-])c1ccc(S(=O)(=O)[O-])cc1N1C(=O)/C(=C\C=C\c2ccccc2)N=C1c1ccccc1,benzene_ring
78501,Please remove a benzene_ring from the molecule CCOc1ccccc1NC(=O)c1cc2sccc2n1CC.,CCOc1ccccc1NC(=O)c1cc2sccc2n1CC,benzene_ring
177711,Remove a benzene_ring from the molecule C[C@H](NCc1ccnc(O[C@H]2CCOC2)c1)c1ccc(C(F)(F)F)cc1.,C[C@H](NCc1ccnc(O[C@H]2CCOC2)c1)c1ccc(C(F)(F)F)cc1,benzene_ring
89063,Remove a halo from the molecule CC(C)n1cnn(C[NH+](CCC(F)(F)F)C2CCCC2)c1=S.,CC(C)n1cnn(C[NH+](CCC(F)(F)F)C2CCCC2)c1=S,halo
159830,Remove a amine from the molecule O=[N+]([O-])c1ccc(Nc2cnn(-c3ncccn3)c2)c(Cl)c1.,O=[N+]([O-])c1ccc(Nc2cnn(-c3ncccn3)c2)c(Cl)c1,amine
193521,Please remove a benzene_ring from the molecule NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H]1C[C@@H]1c1ccc(Cl)c(Cl)c1.,NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H]1C[C@@H]1c1ccc(Cl)c(Cl)c1,benzene_ring
189081,Modify the molecule Cc1ccc(C(C)C)c(OCC(=O)Nn2c(=O)[nH]c3ccccc3c2=O)c1 by removing a benzene_ring.,Cc1ccc(C(C)C)c(OCC(=O)Nn2c(=O)[nH]c3ccccc3c2=O)c1,benzene_ring
84783,Remove a benzene_ring from the molecule O=[N+]([O-])c1ccc(OC/C=C2\Oc3c(cccc3[N+](=O)[O-])[C@H]2N2CCOCC2)cc1.,O=[N+]([O-])c1ccc(OC/C=C2\Oc3c(cccc3[N+](=O)[O-])[C@H]2N2CCOCC2)cc1,benzene_ring
196938,Please remove a amide from the molecule COc1ccc2c(c1)O[C@@]1(CCC(=O)N([C@@H](C)C(=O)[O-])CC1)CC2=O.,COc1ccc2c(c1)O[C@@]1(CCC(=O)N([C@@H](C)C(=O)[O-])CC1)CC2=O,amide
38079,Remove a nitro from the molecule COc1ccc(CNC(=O)C(=O)N/N=C/c2ccccc2[N+](=O)[O-])cc1.,COc1ccc(CNC(=O)C(=O)N/N=C/c2ccccc2[N+](=O)[O-])cc1,nitro
25775,Remove a amide from the molecule CCNC(=O)c1ccccc1NC(=O)c1ccnc(OC(C)(C)C)c1.,CCNC(=O)c1ccccc1NC(=O)c1ccnc(OC(C)(C)C)c1,amide
140454,Please remove a amide from the molecule O=C(c1cn(C(c2ccccc2)c2ccccc2)nn1)N1CC[NH+](Cc2cccnc2)CC1.,O=C(c1cn(C(c2ccccc2)c2ccccc2)nn1)N1CC[NH+](Cc2cccnc2)CC1,amide
171964,Modify the molecule CCNC(=O)Nc1cccc(NC(=O)C(=O)NC2CCCCCC2)c1 by removing a amide.,CCNC(=O)Nc1cccc(NC(=O)C(=O)NC2CCCCCC2)c1,amide
239514,Please remove a amide from the molecule CCCNC(=O)C[NH2+][C@H]1C[C@@H](C)[NH+](C)C[C@@H]1C.,CCCNC(=O)C[NH2+][C@H]1C[C@@H](C)[NH+](C)C[C@@H]1C,amide
25392,Please remove a benzene_ring from the molecule O=C(CSc1nnc(-c2ccccc2Br)n1Cc1ccccc1)C1=NC=CC1.,O=C(CSc1nnc(-c2ccccc2Br)n1Cc1ccccc1)C1=NC=CC1,benzene_ring
178745,Please remove a benzene_ring from the molecule COc1ccc(S(=O)(=O)N2CCC[C@@H]2C(=O)Nc2ccc(C)cc2)cc1.,COc1ccc(S(=O)(=O)N2CCC[C@@H]2C(=O)Nc2ccc(C)cc2)cc1,benzene_ring
106871,Please remove a halo from the molecule O=C(CCc1ccc(O)cc1)N/N=C/c1cc(Cl)cc(Cl)c1O.,O=C(CCc1ccc(O)cc1)N/N=C/c1cc(Cl)cc(Cl)c1O,halo
139970,Modify the molecule CC[NH+](C)C[C@@H]1CCN(C(=O)c2ccc(C[C@@H]3CC(=O)NC3=O)cc2)C1 by removing a amide.,CC[NH+](C)C[C@@H]1CCN(C(=O)c2ccc(C[C@@H]3CC(=O)NC3=O)cc2)C1,amide
7573,Remove a benzene_ring from the molecule C=CCN(Cc1nc(-c2ccccc2)no1)S(=O)(=O)c1ccc(Br)cc1.,C=CCN(Cc1nc(-c2ccccc2)no1)S(=O)(=O)c1ccc(Br)cc1,benzene_ring
151759,Please remove a halo from the molecule Clc1ccc(OCC2=NN3C(=NN[C@@H]3[C@@H]3C=C(c4ccccc4)N=N3)S2)cc1.,Clc1ccc(OCC2=NN3C(=NN[C@@H]3[C@@H]3C=C(c4ccccc4)N=N3)S2)cc1,halo
175994,Please remove a hydroxyl from the molecule CC/C(=N/NC(=O)c1ccc(F)cc1)c1cc(Cl)cc(Cl)c1O.,CC/C(=N/NC(=O)c1ccc(F)cc1)c1cc(Cl)cc(Cl)c1O,hydroxyl
108331,Modify the molecule Cc1nc2ccccn2c1C(=O)Nc1ccc2c(c1)N(C(=O)C(C)C)CCC2 by removing a amide.,Cc1nc2ccccn2c1C(=O)Nc1ccc2c(c1)N(C(=O)C(C)C)CCC2,amide
178729,Remove a benzene_ring from the molecule Cc1cc(C)c(C(=O)CSc2nnc(C3CC3)n2-c2ccccc2)cc1C.,Cc1cc(C)c(C(=O)CSc2nnc(C3CC3)n2-c2ccccc2)cc1C,benzene_ring
147135,Modify the molecule Cc1nnc2ccc(N3CCN(Cc4ccccc4N4CCOCC4)CC3)nn12 by removing a benzene_ring.,Cc1nnc2ccc(N3CCN(Cc4ccccc4N4CCOCC4)CC3)nn12,benzene_ring
106625,Modify the molecule C/C=C/C=C/C(=O)NCc1ccc(S(=O)(=O)NC)s1 by removing a amide.,C/C=C/C=C/C(=O)NCc1ccc(S(=O)(=O)NC)s1,amide
152669,Please remove a amide from the molecule Cc1cccc(C)c1OCC(=O)NC[C@H](C)c1ccsc1.,Cc1cccc(C)c1OCC(=O)NC[C@H](C)c1ccsc1,amide
148301,Remove a nitrile from the molecule C[C@@](CO)(NC(=O)Nc1ccc(OCc2cccc(C#N)c2)cc1)C1CC1.,C[C@@](CO)(NC(=O)Nc1ccc(OCc2cccc(C#N)c2)cc1)C1CC1,nitrile
227042,Remove a nitro from the molecule CC(C)(C)OC(=O)N[C@H]1CCCN(c2nc3cc([N+](=O)[O-])ccc3o2)C1.,CC(C)(C)OC(=O)N[C@H]1CCCN(c2nc3cc([N+](=O)[O-])ccc3o2)C1,nitro
146784,Modify the molecule CC(=O)Nc1cccc(NC(=O)CSc2nc3cc(Cl)ccc3n2Cc2ccccc2)c1 by removing a amide.,CC(=O)Nc1cccc(NC(=O)CSc2nc3cc(Cl)ccc3n2Cc2ccccc2)c1,amide
116523,Remove a halo from the molecule COc1cc2c(c(C[NH+]3CCC(c4nc(C(F)(F)F)c[nH]4)CC3)c1)O[C@H](C)C2.,COc1cc2c(c(C[NH+]3CCC(c4nc(C(F)(F)F)c[nH]4)CC3)c1)O[C@H](C)C2,halo
20940,Modify the molecule CNS(=O)(=O)c1ccc(CNC(=O)N(C[C@@H]2C[C@@H]2C)C(C)C)s1 by removing a amine.,CNS(=O)(=O)c1ccc(CNC(=O)N(C[C@@H]2C[C@@H]2C)C(C)C)s1,amine
117429,Please remove a benzene_ring from the molecule C[C@H](OC(=O)c1cccc(OC[C@@H]2CCCO2)c1)[C@H]1CCCO1.,C[C@H](OC(=O)c1cccc(OC[C@@H]2CCCO2)c1)[C@H]1CCCO1,benzene_ring
238617,Remove a amide from the molecule CCc1[nH]c2ccc(C(=O)N[C@H]3CCCOC3)cc2c1C.,CCc1[nH]c2ccc(C(=O)N[C@H]3CCCOC3)cc2c1C,amide
75061,Modify the molecule O=S(=O)(Nc1ccc2c(c1)OCO2)c1ccccc1Cl by removing a halo.,O=S(=O)(Nc1ccc2c(c1)OCO2)c1ccccc1Cl,halo
27316,Remove a benzene_ring from the molecule COc1ccc(C[NH+]2CCC(Oc3cccc(C#N)c3)CC2)cc1OC.,COc1ccc(C[NH+]2CCC(Oc3cccc(C#N)c3)CC2)cc1OC,benzene_ring
31110,Remove a amide from the molecule CCc1[nH]c([C@H]2C[NH+](C)C[C@@H]2C(=O)N2CCCC2)c(C)[nH+]1.,CCc1[nH]c([C@H]2C[NH+](C)C[C@@H]2C(=O)N2CCCC2)c(C)[nH+]1,amide
156620,Please remove a benzene_ring from the molecule CC/[NH+]=C(/N[C@H]1C[C@@H]1c1cccc(Cl)c1)N[C@@H]1CCC(=O)NC1.,CC/[NH+]=C(/N[C@H]1C[C@@H]1c1cccc(Cl)c1)N[C@@H]1CCC(=O)NC1,benzene_ring
84283,Modify the molecule Cn1c([C@H]2CCCN(C(=O)CCc3cccnc3)C2)n[nH]c1=S by removing a amide.,Cn1c([C@H]2CCCN(C(=O)CCc3cccnc3)C2)n[nH]c1=S,amide
213636,Modify the molecule CCOC(=O)N1CCN(C(=O)c2cccc(OCc3nnnn3C(C)C)c2)CC1 by removing a amide.,CCOC(=O)N1CCN(C(=O)c2cccc(OCc3nnnn3C(C)C)c2)CC1,amide
139904,Modify the molecule O=C(Nc1cnn(-c2ncccn2)c1)Nc1ccc(Cl)cc1Cl by removing a halo.,O=C(Nc1cnn(-c2ncccn2)c1)Nc1ccc(Cl)cc1Cl,halo
149169,Modify the molecule Cc1ccc(NC(=O)C[NH2+]CCc2ccccc2)cc1C by removing a benzene_ring.,Cc1ccc(NC(=O)C[NH2+]CCc2ccccc2)cc1C,benzene_ring
140490,Remove a nitro from the molecule CC(C)=C/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1.,CC(C)=C/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1,nitro
177693,Remove a benzene_ring from the molecule CS(=O)(=O)CCCNC(=O)NCCc1cc(F)ccc1F.,CS(=O)(=O)CCCNC(=O)NCCc1cc(F)ccc1F,benzene_ring
45876,Modify the molecule Cn1c(=O)c2cc(C(=O)N[C@H]3CCOc4ccccc43)cnc2n(C)c1=O by removing a amide.,Cn1c(=O)c2cc(C(=O)N[C@H]3CCOc4ccccc43)cnc2n(C)c1=O,amide
103357,Please remove a amide from the molecule COCCSc1ccccc1C(=O)N1C[C@H](C)O[C@@H](C)C1.,COCCSc1ccccc1C(=O)N1C[C@H](C)O[C@@H](C)C1,amide
229004,Please remove a benzene_ring from the molecule Cc1csc(-c2cccc(C(=O)NC3CC3)c2)n1.,Cc1csc(-c2cccc(C(=O)NC3CC3)c2)n1,benzene_ring
68051,Modify the molecule CCOc1ccc([C@H]2C3=C(CC(C)(C)CC3=O)Nc3nc(SCC)nn32)cc1 by removing a benzene_ring.,CCOc1ccc([C@H]2C3=C(CC(C)(C)CC3=O)Nc3nc(SCC)nn32)cc1,benzene_ring
199768,Modify the molecule CCc1ccc([C@H](CO)NC(=O)Cc2ccc(OC)cc2)cc1 by removing a hydroxyl.,CCc1ccc([C@H](CO)NC(=O)Cc2ccc(OC)cc2)cc1,hydroxyl
219514,Please remove a amide from the molecule CCc1ccccc1NC(=S)N/N=C1\C(=O)N(C)c2ccc(S(=O)(=O)N3CCOCC3)cc21.,CCc1ccccc1NC(=S)N/N=C1\C(=O)N(C)c2ccc(S(=O)(=O)N3CCOCC3)cc21,amide
143948,Modify the molecule CCCn1nnnc1NCc1c(Cl)cccc1Cl by removing a benzene_ring.,CCCn1nnnc1NCc1c(Cl)cccc1Cl,benzene_ring
48464,Modify the molecule CC(C)(C)c1nn(C2CCCCC2)c(N)c1[N+](=O)[O-] by removing a amine.,CC(C)(C)c1nn(C2CCCCC2)c(N)c1[N+](=O)[O-],amine
16210,Modify the molecule O=C(C1=NNc2ccc(Cl)cc2S1(=O)=O)N1CCOCC1 by removing a amide.,O=C(C1=NNc2ccc(Cl)cc2S1(=O)=O)N1CCOCC1,amide
219599,Remove a amide from the molecule CO[C@@H]1CCCC[C@H]1[NH2+]CCC(=O)NC1CC1.,CO[C@@H]1CCCC[C@H]1[NH2+]CCC(=O)NC1CC1,amide
249226,Remove a halo from the molecule Cc1ccc(C(=O)NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(Cl)cc2)cc1.,Cc1ccc(C(=O)NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(Cl)cc2)cc1,halo
50173,Remove a benzene_ring from the molecule C[C@@H](Oc1ccc(Cl)cc1)C(=O)N1CCC(OCc2ccc(F)cc2)CC1.,C[C@@H](Oc1ccc(Cl)cc1)C(=O)N1CCC(OCc2ccc(F)cc2)CC1,benzene_ring
243124,Please remove a benzene_ring from the molecule CN(c1ccccc1)S(=O)(=O)c1cccc(C(=O)OCc2cccc(C#N)c2)c1.,CN(c1ccccc1)S(=O)(=O)c1cccc(C(=O)OCc2cccc(C#N)c2)c1,benzene_ring
23278,Remove a hydroxyl from the molecule Nc1ncnc2c1nc(SCc1ccc3nsnc3c1)n2C[C@H](O)CO.,Nc1ncnc2c1nc(SCc1ccc3nsnc3c1)n2C[C@H](O)CO,hydroxyl
236950,Remove a halo from the molecule Cc1c(N[C@@H](C)C(=O)Nc2cc(Cl)ccc2Cl)c(=O)n(-c2ccccc2)n1C.,Cc1c(N[C@@H](C)C(=O)Nc2cc(Cl)ccc2Cl)c(=O)n(-c2ccccc2)n1C,halo
86283,Please remove a amide from the molecule CN(C(=O)c1cccc2c1OCCO2)c1cccc2ncccc12.,CN(C(=O)c1cccc2c1OCCO2)c1cccc2ncccc12,amide
176313,Remove a halo from the molecule Cc1cc(C)nc(N[C@@]2(C(F)(F)F)N=C(O)N(CCc3ccccc3)C2=O)n1.,Cc1cc(C)nc(N[C@@]2(C(F)(F)F)N=C(O)N(CCc3ccccc3)C2=O)n1,halo
221327,Remove a benzene_ring from the molecule COC(=O)[C@H]1[C@H]2c3ccccc3O[C@]1(C)N=c1s/c(=C\c3ccccc3OC)c(=O)n12.,COC(=O)[C@H]1[C@H]2c3ccccc3O[C@]1(C)N=c1s/c(=C\c3ccccc3OC)c(=O)n12,benzene_ring
26247,Modify the molecule CC(C)(C)c1ccc(NC(=O)c2cccc(CN3CCCC3=O)c2)cc1 by removing a benzene_ring.,CC(C)(C)c1ccc(NC(=O)c2cccc(CN3CCCC3=O)c2)cc1,benzene_ring
41286,Please remove a benzene_ring from the molecule Cc1cccc(OC[C@@H](C)[NH2+][C@H](C)c2cccnc2)c1.,Cc1cccc(OC[C@@H](C)[NH2+][C@H](C)c2cccnc2)c1,benzene_ring
219845,Modify the molecule OCC[NH+](C1CC[NH2+]CC1)C1CC1 by removing a hydroxyl.,OCC[NH+](C1CC[NH2+]CC1)C1CC1,hydroxyl
222426,Please remove a amide from the molecule Cc1ncsc1C(=O)NNC(=O)NC[C@H]1CCC(C)(C)c2ccccc21.,Cc1ncsc1C(=O)NNC(=O)NC[C@H]1CCC(C)(C)c2ccccc21,amide
9500,Please remove a benzene_ring from the molecule [NH3+][C@@H](Cc1ccc(F)c(Br)c1)c1ccc(Cl)cn1.,[NH3+][C@@H](Cc1ccc(F)c(Br)c1)c1ccc(Cl)cn1,benzene_ring
67027,Modify the molecule CCCn1nc(C(=O)OCc2cccc(Cl)c2)c2ccccc2c1=O by removing a benzene_ring.,CCCn1nc(C(=O)OCc2cccc(Cl)c2)c2ccccc2c1=O,benzene_ring
190276,Modify the molecule C[C@H](Oc1ccc(Br)cc1)C(=O)Nc1ccc2c(c1)COC2 by removing a amide.,C[C@H](Oc1ccc(Br)cc1)C(=O)Nc1ccc2c(c1)COC2,amide
57111,Modify the molecule CC[C@@H]1CC(=O)N(Cc2ccc(OC)c(C#CCO)c2)C1 by removing a amide.,CC[C@@H]1CC(=O)N(Cc2ccc(OC)c(C#CCO)c2)C1,amide
62476,Remove a benzene_ring from the molecule CSCC[C@@H](C)N(C)C(=O)N[C@H]1CCN(c2ccccc2)C1.,CSCC[C@@H](C)N(C)C(=O)N[C@H]1CCN(c2ccccc2)C1,benzene_ring
82092,Please remove a benzene_ring from the molecule COc1ccccc1S(=O)(=O)N1CCO[C@H](c2ccc(F)c(Cl)c2)C1.,COc1ccccc1S(=O)(=O)N1CCO[C@H](c2ccc(F)c(Cl)c2)C1,benzene_ring
239247,Please remove a benzene_ring from the molecule CC[C@H](Cc1ccc(C)cc1)NC(=O)c1ccc2c(c1)OCC(=O)N2.,CC[C@H](Cc1ccc(C)cc1)NC(=O)c1ccc2c(c1)OCC(=O)N2,benzene_ring
196107,Remove a benzene_ring from the molecule COc1cccc(CNC(=O)[C@@H]2CCCN(c3ccc(-c4cccs4)nn3)C2)c1.,COc1cccc(CNC(=O)[C@@H]2CCCN(c3ccc(-c4cccs4)nn3)C2)c1,benzene_ring
22946,Please remove a amide from the molecule C=CCOc1c(OC)cccc1[C@@H]1CC(=O)Nc2c(-c3ccccc3)csc21.,C=CCOc1c(OC)cccc1[C@@H]1CC(=O)Nc2c(-c3ccccc3)csc21,amide
142883,Modify the molecule CCNC(=O)c1c(NC(=O)c2cc(-c3ccccc3O)[nH]n2)sc2c1CCCC2 by removing a hydroxyl.,CCNC(=O)c1c(NC(=O)c2cc(-c3ccccc3O)[nH]n2)sc2c1CCCC2,hydroxyl
24064,Remove a amide from the molecule Cc1cc(N2CCN(C)C(=O)C2(C)C)c([C@@H](C)[NH3+])cc1F.,Cc1cc(N2CCN(C)C(=O)C2(C)C)c([C@@H](C)[NH3+])cc1F,amide
48789,Remove a benzene_ring from the molecule CCOc1cc(Br)ccc1C(=O)NC1CCCCC1.,CCOc1cc(Br)ccc1C(=O)NC1CCCCC1,benzene_ring
120203,Please remove a amide from the molecule CCN(CC)C(=O)c1ccc2c(c1)N(CC(=O)Nc1ccc(Cl)cc1)C(=O)CS2.,CCN(CC)C(=O)c1ccc2c(c1)N(CC(=O)Nc1ccc(Cl)cc1)C(=O)CS2,amide
249104,Remove a benzene_ring from the molecule CCc1ccccc1N1C[C@@H](C(=O)Nc2ccc([N+](=O)[O-])cc2OC)CC1=O.,CCc1ccccc1N1C[C@@H](C(=O)Nc2ccc([N+](=O)[O-])cc2OC)CC1=O,benzene_ring
230624,Modify the molecule O=C(COc1ccc2oc3ccccc3c2c1)Nc1ccc2c(c1)OCCO2 by removing a amide.,O=C(COc1ccc2oc3ccccc3c2c1)Nc1ccc2c(c1)OCCO2,amide
47215,Modify the molecule CCn1c(=O)oc2cc(NC(=O)c3cc(OC)c(OC)c(OC)c3)ccc21 by removing a amide.,CCn1c(=O)oc2cc(NC(=O)c3cc(OC)c(OC)c(OC)c3)ccc21,amide
8134,Remove a benzene_ring from the molecule C[C@H]1CC(C(=O)N2CCCC[C@@H]2c2ncc(-c3cccc(F)c3)[nH]2)C[C@H](C)O1.,C[C@H]1CC(C(=O)N2CCCC[C@@H]2c2ncc(-c3cccc(F)c3)[nH]2)C[C@H](C)O1,benzene_ring
187323,Please remove a amide from the molecule CN1C(=O)COc2ccc(NC(=O)C(=O)NCCc3c[nH]c4ccccc34)cc21.,CN1C(=O)COc2ccc(NC(=O)C(=O)NCCc3c[nH]c4ccccc34)cc21,amide
116969,Remove a halo from the molecule CC(C)OC(=O)c1cc2c(ccn2-c2ccc(F)cc2)n1C(C)C.,CC(C)OC(=O)c1cc2c(ccn2-c2ccc(F)cc2)n1C(C)C,halo
170996,Please remove a amide from the molecule C[C@H]1CCCCN1C(=O)C[NH+](CC(=O)N1CCCC[C@@H]1C)Cc1ccco1.,C[C@H]1CCCCN1C(=O)C[NH+](CC(=O)N1CCCC[C@@H]1C)Cc1ccco1,amide
105663,Please remove a hydroxyl from the molecule C[C@H](O)[C@H](C)[NH2+]C(C)(C)CC(C)(C)C.,C[C@H](O)[C@H](C)[NH2+]C(C)(C)CC(C)(C)C,hydroxyl
223392,Remove a benzene_ring from the molecule Cc1ccc(C)c(OCC(=O)N/N=C/c2ccc(O)c([N+](=O)[O-])c2)c1C.,Cc1ccc(C)c(OCC(=O)N/N=C/c2ccc(O)c([N+](=O)[O-])c2)c1C,benzene_ring
34671,Please remove a halo from the molecule N#C[C@H](C(=O)[C@@H]1CCC(=O)N1C(=O)c1ccc(Cl)cc1)c1nc2cc(C(F)(F)F)ccc2s1.,N#C[C@H](C(=O)[C@@H]1CCC(=O)N1C(=O)c1ccc(Cl)cc1)c1nc2cc(C(F)(F)F)ccc2s1,halo
197618,Please remove a benzene_ring from the molecule C=CCN(C(=O)Cc1ccc(C)cc1)c1ccccc1.,C=CCN(C(=O)Cc1ccc(C)cc1)c1ccccc1,benzene_ring
191432,Remove a halo from the molecule C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)NNC(=O)Nc1ccc(Cl)cc1.,C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)NNC(=O)Nc1ccc(Cl)cc1,halo
52098,Modify the molecule CCOc1ccc(NC(=O)[C@H](C)Sc2c([O-])on[n+]2-c2ccccc2)cc1 by removing a amide.,CCOc1ccc(NC(=O)[C@H](C)Sc2c([O-])on[n+]2-c2ccccc2)cc1,amide
4602,Please remove a benzene_ring from the molecule C/C(=N/NC(=O)c1ccc(O)cc1)c1cccs1.,C/C(=N/NC(=O)c1ccc(O)cc1)c1cccs1,benzene_ring
53083,Modify the molecule CN(C[C@H](O)c1ccc(F)c(F)c1)[C@@H](CCO)c1ccccc1 by removing a benzene_ring.,CN(C[C@H](O)c1ccc(F)c(F)c1)[C@@H](CCO)c1ccccc1,benzene_ring
27869,Please remove a amide from the molecule CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2c3ccccc3C(=O)N12)C(C)C.,CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2c3ccccc3C(=O)N12)C(C)C,amide
227027,Modify the molecule COC(=O)c1ccc(NC(=O)c2ncccc2C(F)(F)F)cc1Cl by removing a halo.,COC(=O)c1ccc(NC(=O)c2ncccc2C(F)(F)F)cc1Cl,halo
3745,Remove a halo from the molecule O=C(Cc1cccc(F)c1)NCC(=O)N1CCCCC[C@@H]1c1ccncc1.,O=C(Cc1cccc(F)c1)NCC(=O)N1CCCCC[C@@H]1c1ccncc1,halo
111840,Remove a halo from the molecule O=C(CNC(=O)C(c1ccccc1)c1ccccc1)N/N=C/c1ccccc1Cl.,O=C(CNC(=O)C(c1ccccc1)c1ccccc1)N/N=C/c1ccccc1Cl,halo
77021,Modify the molecule Cn1c(C2CC2)nc2cc(NC(=O)C(=O)N[C@@H]3CCCC[C@H]3CO)ccc21 by removing a hydroxyl.,Cn1c(C2CC2)nc2cc(NC(=O)C(=O)N[C@@H]3CCCC[C@H]3CO)ccc21,hydroxyl
203863,Please remove a hydroxyl from the molecule CCOC1CC[NH+](CC[C@H]2CCC[C@H]2O)CC1.,CCOC1CC[NH+](CC[C@H]2CCC[C@H]2O)CC1,hydroxyl
113310,Modify the molecule O=C(CN1CCN(Cc2ccc(F)cc2Cl)C1=O)NCc1cccs1 by removing a benzene_ring.,O=C(CN1CCN(Cc2ccc(F)cc2Cl)C1=O)NCc1cccs1,benzene_ring
188391,Modify the molecule Cc1nc(C)c(CNC(=O)N[C@@H](CO)c2ccc(Cl)cc2)s1 by removing a hydroxyl.,Cc1nc(C)c(CNC(=O)N[C@@H](CO)c2ccc(Cl)cc2)s1,hydroxyl
133732,Please remove a amide from the molecule COc1cc2c(cc1OC)CN(C(=O)CSc1nnc([C@@H]3COc4ccccc4O3)n1C)CC2.,COc1cc2c(cc1OC)CN(C(=O)CSc1nnc([C@@H]3COc4ccccc4O3)n1C)CC2,amide
225286,Remove a halo from the molecule Cc1cc(/C=C2/C(=N)N3C(c4ccccc4)=CSC3=NC2=O)c(C)n1-c1ccc(F)c(Cl)c1.,Cc1cc(/C=C2/C(=N)N3C(c4ccccc4)=CSC3=NC2=O)c(C)n1-c1ccc(F)c(Cl)c1,halo
82720,Modify the molecule C[C@H](N[C@@H]1N=NC(=O)NC1=O)C(=O)N/N=C/c1ccc(Cl)cc1Cl by removing a benzene_ring.,C[C@H](N[C@@H]1N=NC(=O)NC1=O)C(=O)N/N=C/c1ccc(Cl)cc1Cl,benzene_ring
212976,Please remove a amine from the molecule CCOc1ccc(N)cc1C[NH+](CC)Cc1ccccn1.,CCOc1ccc(N)cc1C[NH+](CC)Cc1ccccn1,amine
196847,Remove a benzene_ring from the molecule CCOc1ccc([C@H](C)NC(=O)N2C[C@@H](C)O[C@H](c3ccccc3)C2)cc1OC.,CCOc1ccc([C@H](C)NC(=O)N2C[C@@H](C)O[C@H](c3ccccc3)C2)cc1OC,benzene_ring
84438,Modify the molecule Cc1csc([C@H](NC(=O)c2cnn(C(C)C)c2C)C2CC2)n1 by removing a amide.,Cc1csc([C@H](NC(=O)c2cnn(C(C)C)c2C)C2CC2)n1,amide
184099,Remove a amide from the molecule CC(C)[C@H](CO)[NH2+][C@@H](C)C(=O)N1CCCC1.,CC(C)[C@H](CO)[NH2+][C@@H](C)C(=O)N1CCCC1,amide
43626,Remove a benzene_ring from the molecule Cc1ccc(OCC[C@@H]2CCC[C@@]2([NH3+])CO)cc1C.,Cc1ccc(OCC[C@@H]2CCC[C@@]2([NH3+])CO)cc1C,benzene_ring
50725,Remove a benzene_ring from the molecule CC[C@H](CNC(=O)c1occc1Br)Oc1ccccc1F.,CC[C@H](CNC(=O)c1occc1Br)Oc1ccccc1F,benzene_ring
197696,Please remove a benzene_ring from the molecule Cc1ccc(-n2ncc(NCCNC(=O)c3ccccc3Cl)c(Cl)c2=O)cc1Cl.,Cc1ccc(-n2ncc(NCCNC(=O)c3ccccc3Cl)c(Cl)c2=O)cc1Cl,benzene_ring
82383,Modify the molecule CCSC[C@@H](C)N(C)C(=O)N[C@@H](C)c1nnnn1-c1ccccc1 by removing a benzene_ring.,CCSC[C@@H](C)N(C)C(=O)N[C@@H](C)c1nnnn1-c1ccccc1,benzene_ring
88519,Modify the molecule COc1ccc(Cn2nnnc2[C@H](c2cc3ccc(C)cc3[nH]c2=O)N2CCc3ccccc32)cc1 by removing a benzene_ring.,COc1ccc(Cn2nnnc2[C@H](c2cc3ccc(C)cc3[nH]c2=O)N2CCc3ccccc32)cc1,benzene_ring
96907,Modify the molecule CN(CC(=O)Nc1ccc(Cl)cc1)S(=O)(=O)c1ccc2c(c1)c(=O)n(C)c(=O)n2C by removing a halo.,CN(CC(=O)Nc1ccc(Cl)cc1)S(=O)(=O)c1ccc2c(c1)c(=O)n(C)c(=O)n2C,halo
30780,Remove a halo from the molecule O[C@]12CCCC[C@@H]1C[NH+](Cc1ncccc1C(F)(F)F)CC2.,O[C@]12CCCC[C@@H]1C[NH+](Cc1ncccc1C(F)(F)F)CC2,halo
133997,Please remove a benzene_ring from the molecule C[C@@H]1CCCC[C@H]1n1ccc2nc3ccn(CCc4ccccc4)c(=O)c3cc2c1=O.,C[C@@H]1CCCC[C@H]1n1ccc2nc3ccn(CCc4ccccc4)c(=O)c3cc2c1=O,benzene_ring
113282,Remove a halo from the molecule CC[C@H]([NH2+][C@H](CO)c1ccc(Cl)cc1)c1ccc2c(c1)OCCO2.,CC[C@H]([NH2+][C@H](CO)c1ccc(Cl)cc1)c1ccc2c(c1)OCCO2,halo
224140,Remove a amide from the molecule CC[C@]1(N(C)C)C(=O)N(c2ccccc2)C(=O)N1c1ccccc1.,CC[C@]1(N(C)C)C(=O)N(c2ccccc2)C(=O)N1c1ccccc1,amide
207367,Modify the molecule CCn1c(C(=O)NC2CCCCCC2)cc2cc(S(=O)(=O)N(C)C)ccc21 by removing a amide.,CCn1c(C(=O)NC2CCCCCC2)cc2cc(S(=O)(=O)N(C)C)ccc21,amide
10234,Remove a benzene_ring from the molecule CCCOc1ccc([C@H]([NH3+])CC(=O)[O-])cc1.,CCCOc1ccc([C@H]([NH3+])CC(=O)[O-])cc1,benzene_ring
16395,Remove a amide from the molecule CN(Cc1nc2ccccc2c(=O)[nH]1)C(=O)c1csc(S(=O)(=O)N2CCc3ccccc3C2)c1.,CN(Cc1nc2ccccc2c(=O)[nH]1)C(=O)c1csc(S(=O)(=O)N2CCc3ccccc3C2)c1,amide
189170,Please remove a amide from the molecule C/N=C1/S/C(=C\C(=O)Nc2ccc(Cl)cc2)C(=O)N1C.,C/N=C1/S/C(=C\C(=O)Nc2ccc(Cl)cc2)C(=O)N1C,amide
70665,Please remove a hydroxyl from the molecule COC(=O)[C@H]1ON2CCCC[C@H]2[C@]1(O)C(F)(F)F.,COC(=O)[C@H]1ON2CCCC[C@H]2[C@]1(O)C(F)(F)F,hydroxyl
88836,Modify the molecule O=C(COc1cccc(F)c1)N1CCC[C@@H](c2[nH]cc[nH+]2)C1 by removing a benzene_ring.,O=C(COc1cccc(F)c1)N1CCC[C@@H](c2[nH]cc[nH+]2)C1,benzene_ring
179327,Please remove a halo from the molecule COC(=O)[C@@H]1C[C@H](O)CN1Cc1ccc(Br)c(C)c1.,COC(=O)[C@@H]1C[C@H](O)CN1Cc1ccc(Br)c(C)c1,halo
90759,Please remove a halo from the molecule COc1cc(NC(=O)c2ccc(N(C)C)cc2)c(Cl)cc1NC(=O)c1ccccc1.,COc1cc(NC(=O)c2ccc(N(C)C)cc2)c(Cl)cc1NC(=O)c1ccccc1,halo
46206,Modify the molecule C[C@H]1CCCC[C@@H]1[NH+]1CCC([NH2+]CCCNC(=O)c2ccc(F)cc2)CC1 by removing a halo.,C[C@H]1CCCC[C@@H]1[NH+]1CCC([NH2+]CCCNC(=O)c2ccc(F)cc2)CC1,halo
125494,Please remove a nitro from the molecule O=[N+]([O-])c1cc(C(F)(F)F)cc(Cl)c1F.,O=[N+]([O-])c1cc(C(F)(F)F)cc(Cl)c1F,nitro
29373,Modify the molecule Fc1ccc(NC(=S)N(Cc2cccc(F)c2)C[C@H]2CCCO2)cc1 by removing a amine.,Fc1ccc(NC(=S)N(Cc2cccc(F)c2)C[C@H]2CCCO2)cc1,amine
112522,Please remove a benzene_ring from the molecule Fc1ccccc1C[NH2+]CCC[NH+]1CCOCC1.,Fc1ccccc1C[NH2+]CCC[NH+]1CCOCC1,benzene_ring
245183,Please remove a amide from the molecule CCc1ccccc1-n1cc([O-])c(C(=O)N(C)CC(C)(C)O)n1.,CCc1ccccc1-n1cc([O-])c(C(=O)N(C)CC(C)(C)O)n1,amide
105456,Modify the molecule CC(C)(C)OC(=O)NC[C@@H]1CCCCN1C(=O)c1ccc(C#N)cc1 by removing a nitrile.,CC(C)(C)OC(=O)NC[C@@H]1CCCCN1C(=O)c1ccc(C#N)cc1,nitrile
147888,Please remove a halo from the molecule Cc1cc(Cl)ncc1NC(=O)N1CC[C@H](C)[C@H](O)C1.,Cc1cc(Cl)ncc1NC(=O)N1CC[C@H](C)[C@H](O)C1,halo
128764,Modify the molecule Cc1ccc(Nc2c(C(=O)N3CCCC3)cnc3nc(C)ccc23)cc1 by removing a amide.,Cc1ccc(Nc2c(C(=O)N3CCCC3)cnc3nc(C)ccc23)cc1,amide
236814,Remove a halo from the molecule COC(=O)C(C)(C)NC(=O)c1ccc(-c2cccc(Br)c2)nc1C.,COC(=O)C(C)(C)NC(=O)c1ccc(-c2cccc(Br)c2)nc1C,halo
86602,Please remove a hydroxyl from the molecule Cc1ccc(CC(=O)N2C[C@@H]3CCCC[C@H]3C2)cc1O.,Cc1ccc(CC(=O)N2C[C@@H]3CCCC[C@H]3C2)cc1O,hydroxyl
45618,Remove a amide from the molecule COc1nn(C)cc1C(=O)N1CCC[C@H](C(=O)N2CC[NH+](C3CCCCC3)CC2)C1.,COc1nn(C)cc1C(=O)N1CCC[C@H](C(=O)N2CC[NH+](C3CCCCC3)CC2)C1,amide
32155,Modify the molecule C[C@H]1C[C@H]([NH2+]Cc2ccn(-c3ccccc3)n2)CN1c1ccccc1 by removing a benzene_ring.,C[C@H]1C[C@H]([NH2+]Cc2ccn(-c3ccccc3)n2)CN1c1ccccc1,benzene_ring
19234,Remove a nitrile from the molecule C[C@@H](Nc1ncccc1C#N)c1ccc(Cl)cc1.,C[C@@H](Nc1ncccc1C#N)c1ccc(Cl)cc1,nitrile
113150,Please remove a benzene_ring from the molecule COc1ccc2c(CSc3nnc(-c4ccc(OC(F)F)cc4)o3)cc(=O)oc2c1.,COc1ccc2c(CSc3nnc(-c4ccc(OC(F)F)cc4)o3)cc(=O)oc2c1,benzene_ring
80554,Modify the molecule C/C=C/C=C/C(=O)NNC(=O)[C@@H](C)Oc1ccccc1F by removing a benzene_ring.,C/C=C/C=C/C(=O)NNC(=O)[C@@H](C)Oc1ccccc1F,benzene_ring
5436,Remove a benzene_ring from the molecule Cc1ccc(-c2nnco2)cc1NC(=O)N1CC[C@@H]2CCCC[C@H]21.,Cc1ccc(-c2nnco2)cc1NC(=O)N1CC[C@@H]2CCCC[C@H]21,benzene_ring
100253,Modify the molecule CC[C@H]1C(=O)N[C@](C)(CC)C(=O)N1CC(C)(C)S(C)(=O)=O by removing a amide.,CC[C@H]1C(=O)N[C@](C)(CC)C(=O)N1CC(C)(C)S(C)(=O)=O,amide
130614,Remove a benzene_ring from the molecule CC(C)[C@@H](CO)NC(=O)Cc1c(F)cccc1F.,CC(C)[C@@H](CO)NC(=O)Cc1c(F)cccc1F,benzene_ring
15435,Modify the molecule CCC[NH+]1CCc2c(sc(NC(=O)c3ccnn3C)c2C(=O)OC)C1 by removing a amide.,CCC[NH+]1CCc2c(sc(NC(=O)c3ccnn3C)c2C(=O)OC)C1,amide
16581,Remove a amide from the molecule CNC(=O)C[C@H](C[NH3+])N(C)C(C)C.,CNC(=O)C[C@H](C[NH3+])N(C)C(C)C,amide
150294,Remove a hydroxyl from the molecule COc1cccc(CN2CCN(c3ccnc(OC)c3C#N)C[C@@H]2CCO)c1.,COc1cccc(CN2CCN(c3ccnc(OC)c3C#N)C[C@@H]2CCO)c1,hydroxyl
152290,Modify the molecule CC(=O)c1ccc(NC(=O)[C@H](C)n2nc(-c3ccco3)oc2=O)cc1 by removing a amide.,CC(=O)c1ccc(NC(=O)[C@H](C)n2nc(-c3ccco3)oc2=O)cc1,amide
42803,Remove a hydroxyl from the molecule CC(C)Sc1nc2c(c(=O)[nH]c(=O)n2C)n1C[C@@H](O)COc1ccc(Cl)cc1.,CC(C)Sc1nc2c(c(=O)[nH]c(=O)n2C)n1C[C@@H](O)COc1ccc(Cl)cc1,hydroxyl
84557,Remove a benzene_ring from the molecule CN1CCN(C(=O)CC[C@@H]2CCCN(C(=O)CCCc3ccccc3)C2)CC1.,CN1CCN(C(=O)CC[C@@H]2CCCN(C(=O)CCCc3ccccc3)C2)CC1,benzene_ring
87231,Remove a nitro from the molecule O=C(c1ccccc1)[C@@H]([C@H](c1ccccc1)c1c[nH]c2ccccc12)[N+](=O)[O-].,O=C(c1ccccc1)[C@@H]([C@H](c1ccccc1)c1c[nH]c2ccccc12)[N+](=O)[O-],nitro
57683,Remove a hydroxyl from the molecule CC[C@H](C)[C@@H](O)[C@]1(C[NH3+])CCc2ccccc2C1.,CC[C@H](C)[C@@H](O)[C@]1(C[NH3+])CCc2ccccc2C1,hydroxyl
128233,Please remove a benzene_ring from the molecule Cc1n[nH]c2cc(NC(=O)[C@@H](c3ccccc3)N3CCCCC3=O)ccc12.,Cc1n[nH]c2cc(NC(=O)[C@@H](c3ccccc3)N3CCCCC3=O)ccc12,benzene_ring
137709,Remove a nitro from the molecule COCC[NH2+]CC(=O)Nc1cccc([N+](=O)[O-])c1.,COCC[NH2+]CC(=O)Nc1cccc([N+](=O)[O-])c1,nitro
94342,Modify the molecule CC1(C)[C@H](C(=O)[O-])[C@H]1C(=O)Nc1ccc(C(=O)Nc2cccnc2)c(Cl)c1 by removing a amide.,CC1(C)[C@H](C(=O)[O-])[C@H]1C(=O)Nc1ccc(C(=O)Nc2cccnc2)c(Cl)c1,amide
213105,Please remove a benzene_ring from the molecule CC[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccccc2OCC2CC2)C1.,CC[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccccc2OCC2CC2)C1,benzene_ring
181601,Please remove a benzene_ring from the molecule CC(C)CCOc1ccc(NC(=O)Nc2cccc(-c3nnco3)c2)cc1.,CC(C)CCOc1ccc(NC(=O)Nc2cccc(-c3nnco3)c2)cc1,benzene_ring
131872,Modify the molecule C[C@H]1C[C@@H]([NH+](CC(=O)[O-])CC(F)(F)F)CC[C@H]1C by removing a halo.,C[C@H]1C[C@@H]([NH+](CC(=O)[O-])CC(F)(F)F)CC[C@H]1C,halo
192165,Remove a amide from the molecule CCn1c(S[C@H](C)C(=O)N[C@@H]2CCCC[C@@H]2C)nc2sc(C)c(C)c2c1=O.,CCn1c(S[C@H](C)C(=O)N[C@@H]2CCCC[C@@H]2C)nc2sc(C)c(C)c2c1=O,amide
184770,Modify the molecule COc1cc(/C=C2\S/C(=N/N=C/c3ccco3)NC2=O)ccc1O by removing a amide.,COc1cc(/C=C2\S/C(=N/N=C/c3ccco3)NC2=O)ccc1O,amide
155820,Remove a benzene_ring from the molecule C[NH+]1CC[C@@H](NC(=O)[C@@H]2CCOc3ccccc32)[C@@H]1c1ccc(Cl)cc1.,C[NH+]1CC[C@@H](NC(=O)[C@@H]2CCOc3ccccc32)[C@@H]1c1ccc(Cl)cc1,benzene_ring
5363,Modify the molecule CCC[C@H](NC(=O)c1cc(OC)ccc1Br)C(=O)OC by removing a benzene_ring.,CCC[C@H](NC(=O)c1cc(OC)ccc1Br)C(=O)OC,benzene_ring
36935,Remove a amide from the molecule O=C1CN(C(=O)c2nn(Cc3ccccc3)c3c2CN(C(=O)[C@H]2CC24CCCCC4)CC3)CCN1.,O=C1CN(C(=O)c2nn(Cc3ccccc3)c3c2CN(C(=O)[C@H]2CC24CCCCC4)CC3)CCN1,amide
234291,Modify the molecule CC(=O)Nc1cc(NC(=O)N(CCO)C2CC2)ccc1F by removing a benzene_ring.,CC(=O)Nc1cc(NC(=O)N(CCO)C2CC2)ccc1F,benzene_ring
27491,Please remove a amide from the molecule C[NH+]1CCCCC[C@H]1C(=O)N1CCN(c2ccccc2C#N)CC1.,C[NH+]1CCCCC[C@H]1C(=O)N1CCN(c2ccccc2C#N)CC1,amide
72883,Please remove a amine from the molecule Cc1n[nH]c(N/N=C\c2ccccc2)nc1=O.,Cc1n[nH]c(N/N=C\c2ccccc2)nc1=O,amine
8730,Modify the molecule Cc1ccc(NC(=O)C[C@H](c2cccc(F)c2)n2cccc2)cc1F by removing a amide.,Cc1ccc(NC(=O)C[C@H](c2cccc(F)c2)n2cccc2)cc1F,amide
241789,Please remove a benzene_ring from the molecule CCCCN(c1ccccc1)S(C)(=O)=O.,CCCCN(c1ccccc1)S(C)(=O)=O,benzene_ring
22297,Please remove a amide from the molecule CCc1c(C(=O)N2CCC[C@@H](C(C)(C)C(=O)OC)C2)[nH]c(C)c1C(C)=O.,CCc1c(C(=O)N2CCC[C@@H](C(C)(C)C(=O)OC)C2)[nH]c(C)c1C(C)=O,amide
161175,Modify the molecule Oc1ccc(CNc2cc(-c3ccc(F)cc3)nc3ccnn23)cc1 by removing a benzene_ring.,Oc1ccc(CNc2cc(-c3ccc(F)cc3)nc3ccnn23)cc1,benzene_ring
226003,Please remove a benzene_ring from the molecule CC[NH+]1CCN(c2ccccc2C[NH+](C)[C@H]2CCCc3c2cnn3C)CC1.,CC[NH+]1CCN(c2ccccc2C[NH+](C)[C@H]2CCCc3c2cnn3C)CC1,benzene_ring
177580,Modify the molecule O=C(C[C@@H]1CC(=O)Oc2ccccc21)Nc1ccc2[nH]ccc2c1 by removing a amide.,O=C(C[C@@H]1CC(=O)Oc2ccccc21)Nc1ccc2[nH]ccc2c1,amide
40062,Modify the molecule Cc1ccc(O)c(-c2nc([C@H]3C[NH+]4CCN3CC4)no2)c1 by removing a benzene_ring.,Cc1ccc(O)c(-c2nc([C@H]3C[NH+]4CCN3CC4)no2)c1,benzene_ring
8622,Please remove a benzene_ring from the molecule CC(=O)Nc1cccc(NC(=O)CSc2nnnn2-c2cc(C)ccc2C)c1.,CC(=O)Nc1cccc(NC(=O)CSc2nnnn2-c2cc(C)ccc2C)c1,benzene_ring
107125,Modify the molecule COC(=O)c1cccc(/C=C/[NH+](C)C)c1[N+](=O)[O-] by removing a nitro.,COC(=O)c1cccc(/C=C/[NH+](C)C)c1[N+](=O)[O-],nitro
169066,Modify the molecule C[C@@H](O)[C@H]1CCCC[NH+]1Cc1ccc(F)cc1C#N by removing a halo.,C[C@@H](O)[C@H]1CCCC[NH+]1Cc1ccc(F)cc1C#N,halo
175843,Please remove a benzene_ring from the molecule CCc1ccccc1NC(=O)[C@H](C)[NH+]1CCCSCC1.,CCc1ccccc1NC(=O)[C@H](C)[NH+]1CCCSCC1,benzene_ring
137040,Please remove a benzene_ring from the molecule Cc1cc2nc(S/C(=C\c3ccc(O)cc3)C(=O)[O-])[nH]c2cc1C.,Cc1cc2nc(S/C(=C\c3ccc(O)cc3)C(=O)[O-])[nH]c2cc1C,benzene_ring
100256,Modify the molecule Cc1cccc([C@H](C)C(=O)N(C)CCC2CCN(c3cc[nH+]cc3)CC2)c1 by removing a benzene_ring.,Cc1cccc([C@H](C)C(=O)N(C)CCC2CCN(c3cc[nH+]cc3)CC2)c1,benzene_ring
107523,Remove a amide from the molecule N#Cc1ccsc1NC(=O)CSc1nc2nn(-c3ccccc3)c(=O)c-2c2n1CCCCC2.,N#Cc1ccsc1NC(=O)CSc1nc2nn(-c3ccccc3)c(=O)c-2c2n1CCCCC2,amide
242678,Please remove a amide from the molecule CC(=O)N1CCN(C(=O)C(=O)NCC2CCN(C(=O)c3ccccn3)CC2)CC1.,CC(=O)N1CCN(C(=O)C(=O)NCC2CCN(C(=O)c3ccccn3)CC2)CC1,amide
95593,Please remove a amide from the molecule O=C1C[C@@H](NC(=O)N2CCC[C@@H]2C[NH+]2CCCCC2)CN1C1CC1.,O=C1C[C@@H](NC(=O)N2CCC[C@@H]2C[NH+]2CCCCC2)CN1C1CC1,amide
22400,Remove a halo from the molecule CN1CCN(C(=O)c2cccn(Cc3ccc(C(F)(F)F)cc3)c2=O)CC1.,CN1CCN(C(=O)c2cccn(Cc3ccc(C(F)(F)F)cc3)c2=O)CC1,halo
212434,Modify the molecule c1cnc(Oc2ccc(CN3CCCC[C@@H]3c3[nH]cc[nH+]3)cc2)cn1 by removing a benzene_ring.,c1cnc(Oc2ccc(CN3CCCC[C@@H]3c3[nH]cc[nH+]3)cc2)cn1,benzene_ring
115914,Please remove a benzene_ring from the molecule COCCOc1cccc(NC(=O)N[C@@H](C)c2c(C)noc2C)c1.,COCCOc1cccc(NC(=O)N[C@@H](C)c2c(C)noc2C)c1,benzene_ring
61049,Remove a benzene_ring from the molecule CCOc1ccc(NC(=O)[C@H]2Sc3nnc(CC)n3N[C@@H]2c2ccc(OC)c(Cl)c2)cc1.,CCOc1ccc(NC(=O)[C@H]2Sc3nnc(CC)n3N[C@@H]2c2ccc(OC)c(Cl)c2)cc1,benzene_ring
238387,Please remove a amide from the molecule Cc1csc([C@@H](C)NC(=O)C[C@@H](NC(N)=O)c2cccs2)n1.,Cc1csc([C@@H](C)NC(=O)C[C@@H](NC(N)=O)c2cccs2)n1,amide
179768,Modify the molecule CN(C)C(=O)c1cc(NC(=O)C(C)(C)F)ccc1Cl by removing a halo.,CN(C)C(=O)c1cc(NC(=O)C(C)(C)F)ccc1Cl,halo
99537,Modify the molecule O=C(Nc1cnc2ccccc2n1)c1cc2c([nH]c1=O)CCCC2 by removing a amide.,O=C(Nc1cnc2ccccc2n1)c1cc2c([nH]c1=O)CCCC2,amide
206149,Please remove a hydroxyl from the molecule N#CC1=C(N)Oc2cc(O)ccc2[C@@H]1c1ccncc1.,N#CC1=C(N)Oc2cc(O)ccc2[C@@H]1c1ccncc1,hydroxyl
226632,Modify the molecule Cc1nnc(C[NH+]2CC[C@@H](COCc3ccccc3)C2)o1 by removing a benzene_ring.,Cc1nnc(C[NH+]2CC[C@@H](COCc3ccccc3)C2)o1,benzene_ring
48965,Modify the molecule O=S(=O)(Oc1ccccc1C(F)(F)F)c1cc(F)ccc1Cl by removing a halo.,O=S(=O)(Oc1ccccc1C(F)(F)F)c1cc(F)ccc1Cl,halo
215934,Modify the molecule [NH2+]=C([C@@H]1CSCCO1)N1CCCC1 by removing a amine.,[NH2+]=C([C@@H]1CSCCO1)N1CCCC1,amine
212176,Please remove a hydroxyl from the molecule O=C(C[C@H]1CCCCO1)N1CCCc2cccc(O)c21.,O=C(C[C@H]1CCCCO1)N1CCCc2cccc(O)c21,hydroxyl
133548,Please remove a amide from the molecule COc1ccc(C(=O)Nc2ccc3c(C(C)(C)C)cc(=O)[nH]c3c2)c(OC)c1.,COc1ccc(C(=O)Nc2ccc3c(C(C)(C)C)cc(=O)[nH]c3c2)c(OC)c1,amide
206606,Remove a amide from the molecule O=C(C[NH+]1CCC[C@H](c2nc3ccccc3o2)C1)NC1CCCCC1.,O=C(C[NH+]1CCC[C@H](c2nc3ccccc3o2)C1)NC1CCCCC1,amide
8874,Please remove a benzene_ring from the molecule COCc1ccccc1NC(=O)NC[C@@H](O)c1ccc2ccccc2c1.,COCc1ccccc1NC(=O)NC[C@@H](O)c1ccc2ccccc2c1,benzene_ring
124547,Remove a hydroxyl from the molecule C[C@H](O)[C@@H]1CCC[NH+](CCc2ccc3c(c2)CCO3)C1.,C[C@H](O)[C@@H]1CCC[NH+](CCc2ccc3c(c2)CCO3)C1,hydroxyl
42977,Modify the molecule CON(C)S(=O)(=O)c1cccc(C(=O)Nc2ccc(C)cc2F)c1 by removing a amide.,CON(C)S(=O)(=O)c1cccc(C(=O)Nc2ccc(C)cc2F)c1,amide
68771,Remove a benzene_ring from the molecule COC[C@@H](NS(=O)(=O)c1cc(C)c(C)cc1[N+](=O)[O-])c1ccco1.,COC[C@@H](NS(=O)(=O)c1cc(C)c(C)cc1[N+](=O)[O-])c1ccco1,benzene_ring
156977,Remove a amide from the molecule C[C@H](Oc1ccccc1)C(=O)NCc1ccc(C(=O)N2CC[NH+](C)CC2)cc1.,C[C@H](Oc1ccccc1)C(=O)NCc1ccc(C(=O)N2CC[NH+](C)CC2)cc1,amide
73112,Please remove a amine from the molecule C[C@@H](C[C@@H]1CCC[NH2+]1)Nc1cnc2ccccc2c1.,C[C@@H](C[C@@H]1CCC[NH2+]1)Nc1cnc2ccccc2c1,amine
6758,Modify the molecule c1cnc(CNC[C@@H]2CCC[NH2+]2)cn1 by removing a amine.,c1cnc(CNC[C@@H]2CCC[NH2+]2)cn1,amine
62495,Remove a nitro from the molecule CCN(c1ncnc(NC[C@H]2CCCO2)c1[N+](=O)[O-])c1cccc2ccccc12.,CCN(c1ncnc(NC[C@H]2CCCO2)c1[N+](=O)[O-])c1cccc2ccccc12,nitro
193258,Please remove a hydroxyl from the molecule Cc1ccc(C(=O)N2CCC3(CCC(=O)N(CC(=O)[O-])C3)CC2)cc1O.,Cc1ccc(C(=O)N2CCC3(CCC(=O)N(CC(=O)[O-])C3)CC2)cc1O,hydroxyl
76375,Please remove a benzene_ring from the molecule CC(C)(C)C(=O)NCC(=O)OC(c1ccccc1)c1ccccc1.,CC(C)(C)C(=O)NCC(=O)OC(c1ccccc1)c1ccccc1,benzene_ring
120590,Remove a amine from the molecule Cc1c(C(=O)N2CCCCC2)c(S(=O)(=O)NCc2ccc3c(c2)OCO3)c(C)n1C.,Cc1c(C(=O)N2CCCCC2)c(S(=O)(=O)NCc2ccc3c(c2)OCO3)c(C)n1C,amine
243734,Please remove a benzene_ring from the molecule Cc1ccnc(NC(=O)[C@H](Cc2ccccc2)N2C(=O)c3ccccc3C2=O)c1.,Cc1ccnc(NC(=O)[C@H](Cc2ccccc2)N2C(=O)c3ccccc3C2=O)c1,benzene_ring
213350,Please remove a amide from the molecule NC(=O)[C@@H]1CN(C(=O)[C@@H]2CCC[NH+]2Cc2ccc(F)cc2)CCO1.,NC(=O)[C@@H]1CN(C(=O)[C@@H]2CCC[NH+]2Cc2ccc(F)cc2)CCO1,amide
205260,Modify the molecule C[C@H]1CN([C@H](C)c2ccc(Cl)s2)C(=O)NC1=O by removing a amide.,C[C@H]1CN([C@H](C)c2ccc(Cl)s2)C(=O)NC1=O,amide
22662,Please remove a halo from the molecule O=C(c1cnn2c1N[C@H](c1ccccc1)C[C@H]2C(F)(F)F)N1CC[NH+](Cc2ccccc2)CC1.,O=C(c1cnn2c1N[C@H](c1ccccc1)C[C@H]2C(F)(F)F)N1CC[NH+](Cc2ccccc2)CC1,halo
121507,Remove a amide from the molecule CCOc1cccc(/C=N\NC(=O)[C@H]2COc3cc4ccccc4cc3O2)c1O.,CCOc1cccc(/C=N\NC(=O)[C@H]2COc3cc4ccccc4cc3O2)c1O,amide
204892,Remove a amide from the molecule CC(C)c1nnnn1CC(=O)NCCc1ccc(N(C)C)cc1.,CC(C)c1nnnn1CC(=O)NCCc1ccc(N(C)C)cc1,amide
53940,Modify the molecule COc1cc(OCC(=O)[C@H](C#N)c2ccc(F)cn2)ccc1[N+](=O)[O-] by removing a halo.,COc1cc(OCC(=O)[C@H](C#N)c2ccc(F)cn2)ccc1[N+](=O)[O-],halo
19135,Please remove a amide from the molecule CCn1cc([C@H](NC(=O)CCC[NH3+])c2ccc(F)cc2)c2cc[nH+]cc21.,CCn1cc([C@H](NC(=O)CCC[NH3+])c2ccc(F)cc2)c2cc[nH+]cc21,amide
35661,Remove a halo from the molecule CC(=O)c1sc(NC(=O)c2ccc(Cl)s2)nc1-c1ccccc1.,CC(=O)c1sc(NC(=O)c2ccc(Cl)s2)nc1-c1ccccc1,halo
161331,Please remove a amine from the molecule N[C@H](Cc1ccccc1)C(=O)N1CCn2nc(CCC(=O)NC3CC3)cc2C1.,N[C@H](Cc1ccccc1)C(=O)N1CCn2nc(CCC(=O)NC3CC3)cc2C1,amine
145256,Remove a benzene_ring from the molecule Cc1cccc(/C([O-])=N/S(=O)(=O)c2sc(C)nc2C)c1.,Cc1cccc(/C([O-])=N/S(=O)(=O)c2sc(C)nc2C)c1,benzene_ring
221407,Please remove a amide from the molecule O=C1CC[C@]2(CCCN(c3cnccn3)C2)CN1CCc1c[nH]c[nH+]1.,O=C1CC[C@]2(CCCN(c3cnccn3)C2)CN1CCc1c[nH]c[nH+]1,amide
103491,Please remove a benzene_ring from the molecule CCc1ccc(-c2n[nH]c(SCc3cc(=O)n4ccsc4n3)n2)cc1.,CCc1ccc(-c2n[nH]c(SCc3cc(=O)n4ccsc4n3)n2)cc1,benzene_ring
135235,Modify the molecule C=CCSc1ccccc1NCc1ccc([O-])c[nH+]1 by removing a amine.,C=CCSc1ccccc1NCc1ccc([O-])c[nH+]1,amine
176153,Remove a halo from the molecule O=C(Nc1cccc(Cl)c1)c1nnc([C@H]2CCCN(C(=O)c3cccc(F)c3)C2)s1.,O=C(Nc1cccc(Cl)c1)c1nnc([C@H]2CCCN(C(=O)c3cccc(F)c3)C2)s1,halo
106789,Modify the molecule COC(=O)CCC(=O)NCC1CCN(c2cc[nH+]cc2)CC1 by removing a amide.,COC(=O)CCC(=O)NCC1CCN(c2cc[nH+]cc2)CC1,amide
178759,Please remove a benzene_ring from the molecule CC(C)(C)c1nnc(C[NH+]2CCCC[C@@H]2CCc2ccccc2)o1.,CC(C)(C)c1nnc(C[NH+]2CCCC[C@@H]2CCc2ccccc2)o1,benzene_ring
31381,Remove a hydroxyl from the molecule COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)[NH+](CC2CC2)CC[C@]314.,COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)[NH+](CC2CC2)CC[C@]314,hydroxyl
52263,Modify the molecule CC[NH+](CC(=O)Nc1c(C)cc(C)cc1C)[C@H]1CCS(=O)(=O)C1 by removing a amide.,CC[NH+](CC(=O)Nc1c(C)cc(C)cc1C)[C@H]1CCS(=O)(=O)C1,amide
136775,Please remove a amide from the molecule CNC(=O)c1cccc(NC(=O)C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)c1C.,CNC(=O)c1cccc(NC(=O)C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)c1C,amide
101471,Modify the molecule C[NH2+][C@]1(CO)CCC[C@@H]([NH+]2C[C@@H](C)CC[C@H]2C)C1 by removing a hydroxyl.,C[NH2+][C@]1(CO)CCC[C@@H]([NH+]2C[C@@H](C)CC[C@H]2C)C1,hydroxyl
215485,Modify the molecule COc1cc2c(cc1CN1CCO[C@@H](c3ccc(F)cc3)C1)OCCCO2 by removing a halo.,COc1cc2c(cc1CN1CCO[C@@H](c3ccc(F)cc3)C1)OCCCO2,halo
141846,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)N2CCN(C(=O)[C@H](C)Sc3ccccn3)CC2)cc1.,Cc1ccc(C(=O)N2CCN(C(=O)[C@H](C)Sc3ccccn3)CC2)cc1,benzene_ring
76646,Please remove a amine from the molecule Cc1cccc(C)c1OCC(=O)/N=C1/NCCS1.,Cc1cccc(C)c1OCC(=O)/N=C1/NCCS1,amine
155425,Modify the molecule O=c1oc(-c2cccs2)nn1CN1CCN(c2ncccc2F)CC1 by removing a halo.,O=c1oc(-c2cccs2)nn1CN1CCN(c2ncccc2F)CC1,halo
58330,Please remove a halo from the molecule CC[NH2+][C@@H](c1ccc(F)c(F)c1)[C@H](C)OC.,CC[NH2+][C@@H](c1ccc(F)c(F)c1)[C@H](C)OC,halo
89487,Modify the molecule COC(=O)[C@H](NC(=O)Cc1ccc(C)c(O)c1)C(C)(C)C by removing a hydroxyl.,COC(=O)[C@H](NC(=O)Cc1ccc(C)c(O)c1)C(C)(C)C,hydroxyl
7318,Remove a amide from the molecule O=C(COC1CCCCC1)NC1CC[NH+](CCc2ccncc2)CC1.,O=C(COC1CCCCC1)NC1CC[NH+](CCc2ccncc2)CC1,amide
4572,Modify the molecule Cc1nc2n(n1)C[C@@H]([NH2+]Cc1cn(-c3ccccc3)nn1)CC2 by removing a benzene_ring.,Cc1nc2n(n1)C[C@@H]([NH2+]Cc1cn(-c3ccccc3)nn1)CC2,benzene_ring
229843,Please remove a halo from the molecule O=C(NCCCn1cccc1)c1c(F)cccc1Cl.,O=C(NCCCn1cccc1)c1c(F)cccc1Cl,halo
183162,Remove a nitro from the molecule O=[N+]([O-])c1ccc(-c2nc(CN3CC[NH+]4CCCC[C@@H]4C3)co2)cc1.,O=[N+]([O-])c1ccc(-c2nc(CN3CC[NH+]4CCCC[C@@H]4C3)co2)cc1,nitro
114270,Modify the molecule CCc1ccccc1CNC(=O)Nc1ccc(OC)cc1C by removing a benzene_ring.,CCc1ccccc1CNC(=O)Nc1ccc(OC)cc1C,benzene_ring
34820,Modify the molecule Cc1cc([C@H](c2ccccc2Cl)N2CC[NH+](C)CC2)c(NC(=O)c2ccco2)s1 by removing a halo.,Cc1cc([C@H](c2ccccc2Cl)N2CC[NH+](C)CC2)c(NC(=O)c2ccco2)s1,halo
864,Remove a hydroxyl from the molecule CS(=O)(=O)N1CCC[C@@H](C[NH+]2CCC[C@H](CO)C2)C1.,CS(=O)(=O)N1CCC[C@@H](C[NH+]2CCC[C@H](CO)C2)C1,hydroxyl
43103,Please remove a amide from the molecule COc1ccccc1NC(=O)c1cc(S(=O)(=O)N2CCCC2)cn1C.,COc1ccccc1NC(=O)c1cc(S(=O)(=O)N2CCCC2)cn1C,amide
79488,Please remove a halo from the molecule CCOC(=O)C1=C(CC)NC2=C(C(=O)CCC2)[C@@H]1c1ccccc1Cl.,CCOC(=O)C1=C(CC)NC2=C(C(=O)CCC2)[C@@H]1c1ccccc1Cl,halo
11221,Please remove a halo from the molecule Cn1cc(C[NH+]2CCC[C@H](O)C2)c(-c2ccccc2F)n1.,Cn1cc(C[NH+]2CCC[C@H](O)C2)c(-c2ccccc2F)n1,halo
204679,Modify the molecule CC(C)c1ccc(OCc2nnc(S)n2C)cc1 by removing a thiol.,CC(C)c1ccc(OCc2nnc(S)n2C)cc1,thiol
211949,Modify the molecule Cc1ccc(C(=O)NCCCNC(=O)C(C)(C)C)cn1 by removing a amide.,Cc1ccc(C(=O)NCCCNC(=O)C(C)(C)C)cn1,amide
129110,Remove a benzene_ring from the molecule CC1=CC=CC2=[NH+][C@@H](c3ccc(C)cc3)CN12.,CC1=CC=CC2=[NH+][C@@H](c3ccc(C)cc3)CN12,benzene_ring
208864,Modify the molecule COCCN(C(C)=O)c1nc(Cn2nc(C(C)(C)C)ccc2=O)cs1 by removing a amide.,COCCN(C(C)=O)c1nc(Cn2nc(C(C)(C)C)ccc2=O)cs1,amide
174868,Remove a halo from the molecule C[C@H](CC(=O)[O-])Sc1ccc(F)cc1.,C[C@H](CC(=O)[O-])Sc1ccc(F)cc1,halo
216827,Please remove a nitro from the molecule C=CCN(C(=O)Cc1ccc(C)nc1)c1nc(-c2ccc([N+](=O)[O-])cc2)cs1.,C=CCN(C(=O)Cc1ccc(C)nc1)c1nc(-c2ccc([N+](=O)[O-])cc2)cs1,nitro
231358,Remove a benzene_ring from the molecule CC(=O)Nc1cccc(NC(=O)c2ccc3c(c2)C(=O)N(CCCc2ccccc2)C3=O)c1.,CC(=O)Nc1cccc(NC(=O)c2ccc3c(c2)C(=O)N(CCCc2ccccc2)C3=O)c1,benzene_ring
216266,Remove a benzene_ring from the molecule CCCSC[C@H]([NH3+])c1cc(OC)cc(OC)c1.,CCCSC[C@H]([NH3+])c1cc(OC)cc(OC)c1,benzene_ring
84347,Please remove a halo from the molecule FC(F)(F)CCn1c(=S)[nH]c2cc(Br)cnc21.,FC(F)(F)CCn1c(=S)[nH]c2cc(Br)cnc21,halo
127918,Modify the molecule CCn1ccnc1SCc1cccc(NC(=O)OC(C)(C)C)c1 by removing a benzene_ring.,CCn1ccnc1SCc1cccc(NC(=O)OC(C)(C)C)c1,benzene_ring
132090,Modify the molecule C[C@H]1COC2(CCN(C(=O)NCC3(c4ccccc4)CCC3)CC2)O1 by removing a benzene_ring.,C[C@H]1COC2(CCN(C(=O)NCC3(c4ccccc4)CCC3)CC2)O1,benzene_ring
12906,Modify the molecule C[C@@H](NC(=O)CSc1nnc(-c2ccc(F)cc2)o1)c1ccc2c(c1)CCCC2 by removing a benzene_ring.,C[C@@H](NC(=O)CSc1nnc(-c2ccc(F)cc2)o1)c1ccc2c(c1)CCCC2,benzene_ring
58362,Please remove a benzene_ring from the molecule CC[C@@H](C)C(=O)CSc1nnc(-c2ccncc2)n1-c1ccccc1C.,CC[C@@H](C)C(=O)CSc1nnc(-c2ccncc2)n1-c1ccccc1C,benzene_ring
218097,Remove a benzene_ring from the molecule CS[C@H]1CC[C@H](NC(=O)c2ccccc2OC2CCC2)C1.,CS[C@H]1CC[C@H](NC(=O)c2ccccc2OC2CCC2)C1,benzene_ring
110659,Modify the molecule Cc1ccc2nc(S[C@@H](C)C(=O)Nc3nccs3)[nH]c2c1 by removing a amide.,Cc1ccc2nc(S[C@@H](C)C(=O)Nc3nccs3)[nH]c2c1,amide
52081,Remove a amide from the molecule C[C@@H](c1nc2ccccc2s1)N1CC[NH+](CC(=O)N2CCCCC2)CC1.,C[C@@H](c1nc2ccccc2s1)N1CC[NH+](CC(=O)N2CCCCC2)CC1,amide
62441,Please remove a amide from the molecule C[NH2+][C@]1(C(N)=O)CCC[C@H]1CCSC1CCOCC1.,C[NH2+][C@]1(C(N)=O)CCC[C@H]1CCSC1CCOCC1,amide
191276,Please remove a amine from the molecule c1ccc2c(c1)OC[C@H]2CNCc1cc2c(s1)CCC2.,c1ccc2c(c1)OC[C@H]2CNCc1cc2c(s1)CCC2,amine
237220,Please remove a benzene_ring from the molecule CCc1ccc([C@@H](C)NC(=O)[C@H](C)Oc2ccccc2)cc1.,CCc1ccc([C@@H](C)NC(=O)[C@H](C)Oc2ccccc2)cc1,benzene_ring
240685,Modify the molecule CCOCCn1/c(=N/C(=O)Cc2cccs2)sc2cc(S(N)(=O)=O)ccc21 by removing a amine.,CCOCCn1/c(=N/C(=O)Cc2cccs2)sc2cc(S(N)(=O)=O)ccc21,amine
45151,Modify the molecule NC(=O)[C@@H]1CCCN1C1CC[NH+](CCCNC(=O)C(F)(F)F)CC1 by removing a halo.,NC(=O)[C@@H]1CCCN1C1CC[NH+](CCCNC(=O)C(F)(F)F)CC1,halo
149108,Please remove a halo from the molecule Cc1c([C@H](C)[NH2+]Cc2cnn(-c3ccccc3)c2)cnn1-c1cccc(F)c1.,Cc1c([C@H](C)[NH2+]Cc2cnn(-c3ccccc3)c2)cnn1-c1cccc(F)c1,halo
110208,Remove a benzene_ring from the molecule Cc1ccc(C)c(S(=O)(=O)NCc2nc(-c3ccccc3)no2)c1.,Cc1ccc(C)c(S(=O)(=O)NCc2nc(-c3ccccc3)no2)c1,benzene_ring
89346,Modify the molecule Cc1ccc(NC(=S)N2CCN(C/C=C/c3ccccc3)CC2)c(C)c1 by removing a amine.,Cc1ccc(NC(=S)N2CCN(C/C=C/c3ccccc3)CC2)c(C)c1,amine
3520,Modify the molecule CC(C)(C)c1ccc(=O)n(CCCOc2ccc(F)cc2)n1 by removing a halo.,CC(C)(C)c1ccc(=O)n(CCCOc2ccc(F)cc2)n1,halo
136916,Please remove a nitrile from the molecule COc1ccc(/C=C(\C#N)C(=O)N(C)C)c2ccccc12.,COc1ccc(/C=C(\C#N)C(=O)N(C)C)c2ccccc12,nitrile
244571,Remove a benzene_ring from the molecule CCN(C(=O)[C@H]1C[C@H]2CC[C@@H]1O2)c1ccc(C)cc1C.,CCN(C(=O)[C@H]1C[C@H]2CC[C@@H]1O2)c1ccc(C)cc1C,benzene_ring
185698,Modify the molecule O=C1N/C(=C\c2cn(Cc3ccc(F)cc3)c3ccccc23)C(=O)N1Cc1ccccc1F by removing a halo.,O=C1N/C(=C\c2cn(Cc3ccc(F)cc3)c3ccccc23)C(=O)N1Cc1ccccc1F,halo
94684,Modify the molecule CC(C)(C)OC(=O)N1CC[C@H](COc2nc3cc([N+](=O)[O-])ccc3o2)C1 by removing a nitro.,CC(C)(C)OC(=O)N1CC[C@H](COc2nc3cc([N+](=O)[O-])ccc3o2)C1,nitro
131461,Modify the molecule Cc1ccc(NC(=O)[C@H]2CC(=O)N(Cc3ccco3)C2)nc1 by removing a amide.,Cc1ccc(NC(=O)[C@H]2CC(=O)N(Cc3ccco3)C2)nc1,amide
110896,Please remove a benzene_ring from the molecule COc1cccc(C[C@@H](C)NC(=O)c2ccccc2C(C)=O)c1.,COc1cccc(C[C@@H](C)NC(=O)c2ccccc2C(C)=O)c1,benzene_ring
72728,Please remove a amine from the molecule Cc1ccc(N2C(=O)S[C@H](Nc3cccc(F)c3)C2=O)cc1C.,Cc1ccc(N2C(=O)S[C@H](Nc3cccc(F)c3)C2=O)cc1C,amine
190903,Please remove a amide from the molecule O=C(c1ccc(N2CCCC2=O)cc1)N1CCC[C@@H](c2nc3ccccc3[nH]2)C1.,O=C(c1ccc(N2CCCC2=O)cc1)N1CCC[C@@H](c2nc3ccccc3[nH]2)C1,amide
110633,Modify the molecule Cc1ccc2nc(N(C[C@@H]3CCCO3)C(=O)CCS(=O)(=O)c3ccccc3)sc2c1 by removing a benzene_ring.,Cc1ccc2nc(N(C[C@@H]3CCCO3)C(=O)CCS(=O)(=O)c3ccccc3)sc2c1,benzene_ring
23946,Remove a amide from the molecule O=C(/C=C/c1ccc(O)cc1)NC[C@@H]1CC[C@H](C(=O)[O-])O1.,O=C(/C=C/c1ccc(O)cc1)NC[C@@H]1CC[C@H](C(=O)[O-])O1,amide
186254,Remove a halo from the molecule CN1CCn2c([nH+]c3cc([N-]S(=O)(=O)c4ccc(Cl)cc4)ccc32)C1.,CN1CCn2c([nH+]c3cc([N-]S(=O)(=O)c4ccc(Cl)cc4)ccc32)C1,halo
37472,Remove a amide from the molecule COC(=O)[C@@H]1CN(C(C)=O)C[C@@H]1C.,COC(=O)[C@@H]1CN(C(C)=O)C[C@@H]1C,amide
143099,Modify the molecule COc1ccc(Cn2c(N)c3ccccc3nc2=S)cc1 by removing a amine.,COc1ccc(Cn2c(N)c3ccccc3nc2=S)cc1,amine
75085,Modify the molecule CC(=O)N1CCC(C(=O)N2CCC(c3[nH+]ccn3Cc3ccccn3)CC2)CC1 by removing a amide.,CC(=O)N1CCC(C(=O)N2CCC(c3[nH+]ccn3Cc3ccccn3)CC2)CC1,amide
150354,Remove a halo from the molecule Cc1cc2cc(CN3CCn4c(nnc4C(F)(F)F)C3)oc2cc1C.,Cc1cc2cc(CN3CCn4c(nnc4C(F)(F)F)C3)oc2cc1C,halo
24244,Modify the molecule CC[C@H](C)[NH2+]Cc1ccccc1 by removing a benzene_ring.,CC[C@H](C)[NH2+]Cc1ccccc1,benzene_ring
142155,Please remove a amide from the molecule Cc1ccc(NC(=O)C(=O)N2CCC([NH+]3CCCC3)CC2)c(Cl)n1.,Cc1ccc(NC(=O)C(=O)N2CCC([NH+]3CCCC3)CC2)c(Cl)n1,amide
138494,Modify the molecule C[C@H](NC(=O)COc1ccccc1F)c1cccc(C#N)c1 by removing a nitrile.,C[C@H](NC(=O)COc1ccccc1F)c1cccc(C#N)c1,nitrile
19342,Please remove a amide from the molecule C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)[C@@H]1CCCN(C(N)=O)C1.,C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)[C@@H]1CCCN(C(N)=O)C1,amide
88720,Remove a amide from the molecule O=C1C[C@H](C(=O)Nc2ccc(F)cc2F)[C@@H]2C(=O)N=C(SCc3ccccc3F)N=C2N1.,O=C1C[C@H](C(=O)Nc2ccc(F)cc2F)[C@@H]2C(=O)N=C(SCc3ccccc3F)N=C2N1,amide
82825,Please remove a benzene_ring from the molecule CC(C)COC(=O)c1ccc(NC(=O)[C@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1.,CC(C)COC(=O)c1ccc(NC(=O)[C@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1,benzene_ring
235033,Please remove a benzene_ring from the molecule CCc1ccc(NC(=O)c2cc(OC)no2)cc1.,CCc1ccc(NC(=O)c2cc(OC)no2)cc1,benzene_ring
39461,Please remove a benzene_ring from the molecule CC[C@@H](C)NS(=O)(=O)c1ccc(NC(=O)c2ccc(C)c(Br)c2)cc1.,CC[C@@H](C)NS(=O)(=O)c1ccc(NC(=O)c2ccc(C)c(Br)c2)cc1,benzene_ring
172472,Modify the molecule CCN(CC)C(=O)c1cccc(S(=O)(=O)NC2CC2)c1 by removing a amine.,CCN(CC)C(=O)c1cccc(S(=O)(=O)NC2CC2)c1,amine
58454,Please remove a benzene_ring from the molecule Cc1cc(C)c(C)c(S(=O)(=O)N2CCC([NH+]3CCCCC3)CC2)c1C.,Cc1cc(C)c(C)c(S(=O)(=O)N2CCC([NH+]3CCCCC3)CC2)c1C,benzene_ring
208313,Please remove a benzene_ring from the molecule C[C@H](NC(=O)c1ccc(N)cc1)C(=O)[O-].,C[C@H](NC(=O)c1ccc(N)cc1)C(=O)[O-],benzene_ring
246370,Modify the molecule Cc1cc(C)cc(C[C@H]([NH3+])CSc2ccccc2Cl)c1 by removing a halo.,Cc1cc(C)cc(C[C@H]([NH3+])CSc2ccccc2Cl)c1,halo
222631,Remove a benzene_ring from the molecule COc1ccccc1[C@@H](CNC(=O)N1CC[C@@H]([N+]2=CCCC2)C1)[NH+](C)C.,COc1ccccc1[C@@H](CNC(=O)N1CC[C@@H]([N+]2=CCCC2)C1)[NH+](C)C,benzene_ring
201378,Modify the molecule CCN(CC)C(=O)Cn1cc(Br)c(=O)[nH]c1=O by removing a amide.,CCN(CC)C(=O)Cn1cc(Br)c(=O)[nH]c1=O,amide
111072,Modify the molecule O=C(Nc1ccc(-c2nccs2)cc1)c1ccccc1I by removing a halo.,O=C(Nc1ccc(-c2nccs2)cc1)c1ccccc1I,halo
19937,Modify the molecule CC(=O)N1CCC(C(=O)N2CCOC[C@@H]2C[NH+](C)C)CC1 by removing a amide.,CC(=O)N1CCC(C(=O)N2CCOC[C@@H]2C[NH+](C)C)CC1,amide
38838,Please remove a halo from the molecule CN(Cc1cnn(-c2ccccc2)c1)S(=O)(=O)c1cccc(OC(F)(F)F)c1.,CN(Cc1cnn(-c2ccccc2)c1)S(=O)(=O)c1cccc(OC(F)(F)F)c1,halo
170865,Modify the molecule CNC(=O)Cc1noc(-c2coc3ccccc23)n1 by removing a amide.,CNC(=O)Cc1noc(-c2coc3ccccc23)n1,amide
23086,Remove a benzene_ring from the molecule CCc1nc(C)c([C@H](C)OC(=O)Cc2ccc(N3CCCC3=O)cc2)s1.,CCc1nc(C)c([C@H](C)OC(=O)Cc2ccc(N3CCCC3=O)cc2)s1,benzene_ring
53632,Remove a amine from the molecule CCC[NH+](C1CC1)C1(CN)CCN(C(C)C)CC1.,CCC[NH+](C1CC1)C1(CN)CCN(C(C)C)CC1,amine
202236,Remove a benzene_ring from the molecule COc1ccc(C[C@H](C)CNC(=O)c2ccc(C(N)=O)cn2)cc1.,COc1ccc(C[C@H](C)CNC(=O)c2ccc(C(N)=O)cn2)cc1,benzene_ring
136578,Modify the molecule COc1ccc(CNC(=O)[C@H]2CCCN(C(=O)NC3CC3)C2)cc1 by removing a amide.,COc1ccc(CNC(=O)[C@H]2CCCN(C(=O)NC3CC3)C2)cc1,amide
3096,Remove a halo from the molecule O=C(N=c1[nH]c2ccccc2[nH]1)c1cc(Cl)ccc1[N+](=O)[O-].,O=C(N=c1[nH]c2ccccc2[nH]1)c1cc(Cl)ccc1[N+](=O)[O-],halo
211253,Please remove a amine from the molecule C[C@@H]1CCC[C@](CO)(Nc2nc3cc(N)ccc3o2)C1.,C[C@@H]1CCC[C@](CO)(Nc2nc3cc(N)ccc3o2)C1,amine
218387,Remove a benzene_ring from the molecule NC(=O)N1CCC[C@@H](C(=O)Nc2ccccc2C(=O)NCC(F)(F)F)C1.,NC(=O)N1CCC[C@@H](C(=O)Nc2ccccc2C(=O)NCC(F)(F)F)C1,benzene_ring
24420,Remove a hydroxyl from the molecule CC1(C)CC(NC(=O)N2CCN(C(=O)c3ccc(O)cc3)CC2)CC(C)(C)[NH2+]1.,CC1(C)CC(NC(=O)N2CCN(C(=O)c3ccc(O)cc3)CC2)CC(C)(C)[NH2+]1,hydroxyl
216438,Please remove a amide from the molecule Cc1ccccc1-n1cc(CN(C)C(=O)[C@H]2CCCCC[NH+]2C)cn1.,Cc1ccccc1-n1cc(CN(C)C(=O)[C@H]2CCCCC[NH+]2C)cn1,amide
77743,Remove a halo from the molecule COc1ccc(-n2c(N)c(C(=O)Nc3cccc(F)c3)sc2=S)c(OC)c1.,COc1ccc(-n2c(N)c(C(=O)Nc3cccc(F)c3)sc2=S)c(OC)c1,halo
241348,Please remove a benzene_ring from the molecule Cc1nc(C)c(C(=O)Nc2cccc(NC(=O)NCc3ccncc3)c2)o1.,Cc1nc(C)c(C(=O)Nc2cccc(NC(=O)NCc3ccncc3)c2)o1,benzene_ring
162563,Remove a amine from the molecule Cc1ccc(C)c(S(=O)(=O)NCCNC(=O)[C@H](C)c2cccs2)c1.,Cc1ccc(C)c(S(=O)(=O)NCCNC(=O)[C@H](C)c2cccs2)c1,amine
41279,Modify the molecule C[C@@H](NC(=O)[C@H]1CCCN(C(=O)c2ccc(Cl)cc2)C1)c1ccccc1Br by removing a halo.,C[C@@H](NC(=O)[C@H]1CCCN(C(=O)c2ccc(Cl)cc2)C1)c1ccccc1Br,halo
35500,Remove a amide from the molecule Cn1cc[nH+]c1CNC(=O)CCc1cc(Cl)ccc1Br.,Cn1cc[nH+]c1CNC(=O)CCc1cc(Cl)ccc1Br,amide
196774,Remove a benzene_ring from the molecule COc1cc(C=O)cc(Cl)c1O[C@@H](C)[C@H](C)O.,COc1cc(C=O)cc(Cl)c1O[C@@H](C)[C@H](C)O,benzene_ring
49781,Please remove a halo from the molecule Cc1cc(NC(=O)[C@@H]2C[C@@H]2c2ccccc2)n(-c2ccc(F)cc2)n1.,Cc1cc(NC(=O)[C@@H]2C[C@@H]2c2ccccc2)n(-c2ccc(F)cc2)n1,halo
21157,Modify the molecule C[C@@H]1C(=O)N2CCCc3cc(NC(=O)C(=O)NCC4(c5cccs5)CCOCC4)cc1c32 by removing a amide.,C[C@@H]1C(=O)N2CCCc3cc(NC(=O)C(=O)NCC4(c5cccs5)CCOCC4)cc1c32,amide
207085,Remove a benzene_ring from the molecule COCC1CCN(C(=O)N[C@H]2CCCN(c3ccc(C)cc3)C2=O)CC1.,COCC1CCN(C(=O)N[C@H]2CCCN(c3ccc(C)cc3)C2=O)CC1,benzene_ring
86481,Remove a benzene_ring from the molecule CC[C@H](C)NC(=O)N1CCN(Cc2cc(OC)cc(OC)c2)CC1.,CC[C@H](C)NC(=O)N1CCN(Cc2cc(OC)cc(OC)c2)CC1,benzene_ring
24080,Modify the molecule N#Cc1ccc(N2CCN(C(=O)CCc3n[nH]c4c3CCCC4)CC2=O)cc1 by removing a benzene_ring.,N#Cc1ccc(N2CCN(C(=O)CCc3n[nH]c4c3CCCC4)CC2=O)cc1,benzene_ring
33657,Modify the molecule O=C(N/N=C\c1ccccc1Br)c1ccc(O)cc1O by removing a benzene_ring.,O=C(N/N=C\c1ccccc1Br)c1ccc(O)cc1O,benzene_ring
117403,Remove a amide from the molecule CCOc1ccc(C(=O)Nc2ccnc(C(=O)N(C)C)c2)cc1.,CCOc1ccc(C(=O)Nc2ccnc(C(=O)N(C)C)c2)cc1,amide
60726,Remove a amide from the molecule O=C(NCC(=O)N1CC[C@@H]2CCCC[C@H]21)c1cc2ccccc2[nH]1.,O=C(NCC(=O)N1CC[C@@H]2CCCC[C@H]21)c1cc2ccccc2[nH]1,amide
191143,Modify the molecule CSC(=S)N(C)NC(=O)c1ncccn1 by removing a amide.,CSC(=S)N(C)NC(=O)c1ncccn1,amide
151907,Modify the molecule C[NH+]1CCN(C(C)(C)C(=O)NCC2(c3ccc(F)cc3)CCC2)CC1 by removing a amide.,C[NH+]1CCN(C(C)(C)C(=O)NCC2(c3ccc(F)cc3)CCC2)CC1,amide
215593,Please remove a hydroxyl from the molecule CC[C@@H](C)[C@@](C)(O)C[NH2+]Cc1ncc(-c2ccccc2)s1.,CC[C@@H](C)[C@@](C)(O)C[NH2+]Cc1ncc(-c2ccccc2)s1,hydroxyl
79834,Remove a benzene_ring from the molecule COc1cc(Cl)c(C)cc1NC(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1.,COc1cc(Cl)c(C)cc1NC(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1,benzene_ring
54444,Remove a amine from the molecule CCc1cc2c(N[C@@H](C)c3cccc(S(=O)(=O)NC)c3)ncnc2s1.,CCc1cc2c(N[C@@H](C)c3cccc(S(=O)(=O)NC)c3)ncnc2s1,amine
178302,Please remove a amine from the molecule CCOCCCC(=O)N1c2ccc(N)cc2C[C@H]1C.,CCOCCCC(=O)N1c2ccc(N)cc2C[C@H]1C,amine
59094,Remove a halo from the molecule CCc1nn(C)cc1NS(=O)(=O)c1ccc([N+](=O)[O-])cc1Cl.,CCc1nn(C)cc1NS(=O)(=O)c1ccc([N+](=O)[O-])cc1Cl,halo
75952,Remove a benzene_ring from the molecule Cc1cccc(OCC(=O)Nc2ccc3c(c2)nc(C[NH+]2CCCCC2)n3C)c1.,Cc1cccc(OCC(=O)Nc2ccc3c(c2)nc(C[NH+]2CCCCC2)n3C)c1,benzene_ring
51045,Remove a amine from the molecule Cc1nccc(N[C@H](C)CCC[NH3+])n1.,Cc1nccc(N[C@H](C)CCC[NH3+])n1,amine
6391,Remove a halo from the molecule O=C(CNC(=O)c1ccoc1)Nc1cc(C(F)(F)F)c[nH]c1=O.,O=C(CNC(=O)c1ccoc1)Nc1cc(C(F)(F)F)c[nH]c1=O,halo
97168,Modify the molecule CCn1ncnc1-c1c(-c2ccccc2)ncn1[C@@H](C)Cc1cc(C)n[nH]1 by removing a benzene_ring.,CCn1ncnc1-c1c(-c2ccccc2)ncn1[C@@H](C)Cc1cc(C)n[nH]1,benzene_ring
67065,Please remove a amide from the molecule C[C@@](O)(CNC(=O)CC1([NH3+])CCC1)C(=O)[O-].,C[C@@](O)(CNC(=O)CC1([NH3+])CCC1)C(=O)[O-],amide
117954,Remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)C[NH2+][C@@H](C)c3cccc(F)c3)CC2)cc1.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)C[NH2+][C@@H](C)c3cccc(F)c3)CC2)cc1,benzene_ring
92208,Modify the molecule C=CCN(CC(=O)[O-])C(=O)C1C[NH2+]C1 by removing a amide.,C=CCN(CC(=O)[O-])C(=O)C1C[NH2+]C1,amide
100696,Please remove a amide from the molecule O=C1[C@H]2C[C@@H](Br)[C@H](Br)C[C@@H]2C(=O)N1c1ccc(Cl)cc1.,O=C1[C@H]2C[C@@H](Br)[C@H](Br)C[C@@H]2C(=O)N1c1ccc(Cl)cc1,amide
108658,Modify the molecule Fc1ccc(-n2ncc3c(N4CCCc5ccccc54)ncnc32)cc1 by removing a halo.,Fc1ccc(-n2ncc3c(N4CCCc5ccccc54)ncnc32)cc1,halo
61829,Please remove a halo from the molecule Cc1nn(CC[C@H]2CCC[C@]2(CO)[NH2+]C2CC2)c(C)c1Cl.,Cc1nn(CC[C@H]2CCC[C@]2(CO)[NH2+]C2CC2)c(C)c1Cl,halo
9987,Remove a benzene_ring from the molecule CCNc1nc(NCC)nc(Nc2ccc(C)c(C)c2)n1.,CCNc1nc(NCC)nc(Nc2ccc(C)c(C)c2)n1,benzene_ring
1626,Remove a benzene_ring from the molecule CC[C@H](C(=O)Nc1cccc(CS(=O)(=O)c2ccccc2)c1)c1ccccc1.,CC[C@H](C(=O)Nc1cccc(CS(=O)(=O)c2ccccc2)c1)c1ccccc1,benzene_ring
189635,Remove a amide from the molecule CC(C)[C@H](C)NC(=O)CS(=O)(=O)[C@@H](C)C(C)C.,CC(C)[C@H](C)NC(=O)CS(=O)(=O)[C@@H](C)C(C)C,amide
89313,Modify the molecule Cn1/c(=N/C(=O)c2ccccc2O)[nH]c2cc(Cl)ccc21 by removing a hydroxyl.,Cn1/c(=N/C(=O)c2ccccc2O)[nH]c2cc(Cl)ccc21,hydroxyl
203983,Modify the molecule N#C[C@@H](CCl)C[C@H]1COc2ccccc21 by removing a halo.,N#C[C@@H](CCl)C[C@H]1COc2ccccc21,halo
93111,Modify the molecule Cc1ccc(-n2nnc(C(=O)NCc3ccccc3)c2C(C)C)cc1 by removing a benzene_ring.,Cc1ccc(-n2nnc(C(=O)NCc3ccccc3)c2C(C)C)cc1,benzene_ring
21012,Remove a amide from the molecule O=C(C1CCN(C[C@@H]2CCC[NH+]3CCCC[C@@H]23)CC1)N1CCCC1.,O=C(C1CCN(C[C@@H]2CCC[NH+]3CCCC[C@@H]23)CC1)N1CCCC1,amide
52598,Modify the molecule CC[NH+]1CC[C@H](N(C)Cc2cccc(C(F)(F)F)c2)[C@H](C)C1 by removing a benzene_ring.,CC[NH+]1CC[C@H](N(C)Cc2cccc(C(F)(F)F)c2)[C@H](C)C1,benzene_ring
186516,Please remove a benzene_ring from the molecule CC(=O)N[C@@H](CC(=O)N(C)CC(=O)Nc1c(C)cccc1C)c1ccc(C)cc1.,CC(=O)N[C@@H](CC(=O)N(C)CC(=O)Nc1c(C)cccc1C)c1ccc(C)cc1,benzene_ring
229852,Modify the molecule COC(=O)[C@H](C)CN(Cc1ccccc1)C(=O)c1ccc2n[nH]c(=O)n2c1 by removing a benzene_ring.,COC(=O)[C@H](C)CN(Cc1ccccc1)C(=O)c1ccc2n[nH]c(=O)n2c1,benzene_ring
161951,Modify the molecule CCOC(=O)C1CC[NH+]([C@H](C)C(=O)Nc2cccc(C#N)c2)CC1 by removing a amide.,CCOC(=O)C1CC[NH+]([C@H](C)C(=O)Nc2cccc(C#N)c2)CC1,amide
171258,Remove a benzene_ring from the molecule CC[C@H](C)Sc1cccc(F)c1C(N)=[NH2+].,CC[C@H](C)Sc1cccc(F)c1C(N)=[NH2+],benzene_ring
88727,Remove a halo from the molecule CC(C)(C)Oc1ccc(Cl)cc1Br.,CC(C)(C)Oc1ccc(Cl)cc1Br,halo
150038,Please remove a benzene_ring from the molecule CCn1nnc(NCc2ccc(C)cc2)n1.,CCn1nnc(NCc2ccc(C)cc2)n1,benzene_ring
72188,Remove a halo from the molecule COc1ccc(-c2nnc(NC(=O)c3ccc(Cl)cc3)o2)cc1OC.,COc1ccc(-c2nnc(NC(=O)c3ccc(Cl)cc3)o2)cc1OC,halo
117919,Please remove a nitrile from the molecule C[C@H](CC#N)[NH+](C)Cc1ccc(Cl)o1.,C[C@H](CC#N)[NH+](C)Cc1ccc(Cl)o1,nitrile
125903,Modify the molecule Cc1csc(/C(C#N)=C/c2ccccc2OCC(=O)Nc2ccccc2)n1 by removing a nitrile.,Cc1csc(/C(C#N)=C/c2ccccc2OCC(=O)Nc2ccccc2)n1,nitrile
77399,Please remove a amine from the molecule COc1ccnc(Nc2ccc(N(C)C)[nH+]c2)n1.,COc1ccnc(Nc2ccc(N(C)C)[nH+]c2)n1,amine
177129,Modify the molecule COc1ccc(N[C@H](C)C2CC2)cc1F by removing a benzene_ring.,COc1ccc(N[C@H](C)C2CC2)cc1F,benzene_ring
38802,Modify the molecule Cc1ccc(NC(=O)NCc2ccccc2S(=O)(=O)N(C)C)cc1 by removing a benzene_ring.,Cc1ccc(NC(=O)NCc2ccccc2S(=O)(=O)N(C)C)cc1,benzene_ring
242184,Modify the molecule Cc1cccc(NC(=O)C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2[O-])c1C by removing a amide.,Cc1cccc(NC(=O)C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2[O-])c1C,amide
159594,Remove a nitro from the molecule Cc1ccc(C[C@@H](C)Nc2ccc([N+](=O)[O-])cc2S(N)(=O)=O)c(C)c1.,Cc1ccc(C[C@@H](C)Nc2ccc([N+](=O)[O-])cc2S(N)(=O)=O)c(C)c1,nitro
158945,Modify the molecule CC(C)(C)n1cc(CN2CCN(CC#N)CC2)c(-c2ccccc2Cl)n1 by removing a benzene_ring.,CC(C)(C)n1cc(CN2CCN(CC#N)CC2)c(-c2ccccc2Cl)n1,benzene_ring
175829,Modify the molecule Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cc(C)n(C2CC2)c1C by removing a amide.,Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cc(C)n(C2CC2)c1C,amide
207131,Please remove a amide from the molecule CC[C@H](C)OCC(=O)Nc1cn(C)nc1-c1ccccc1.,CC[C@H](C)OCC(=O)Nc1cn(C)nc1-c1ccccc1,amide
219008,Modify the molecule CCn1cc(C(=O)NC[C@H](c2ccc(F)cc2)[NH+](C)C)cn1 by removing a halo.,CCn1cc(C(=O)NC[C@H](c2ccc(F)cc2)[NH+](C)C)cn1,halo
21903,Modify the molecule O=[N+]([O-])c1ccccc1NCc1cn(-c2ccccc2)nn1 by removing a benzene_ring.,O=[N+]([O-])c1ccccc1NCc1cn(-c2ccccc2)nn1,benzene_ring
86340,Modify the molecule Cc1ccsc1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C by removing a amide.,Cc1ccsc1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C,amide
164156,Remove a halo from the molecule CN(Cc1cnn(C)c1)S(=O)(=O)c1cc(Cl)c(Cl)cc1Cl.,CN(Cc1cnn(C)c1)S(=O)(=O)c1cc(Cl)c(Cl)cc1Cl,halo
11262,Please remove a benzene_ring from the molecule CCCC(=O)N1CCN(c2ccc(NC(=O)COc3ccc(C)cc3)cc2)CC1.,CCCC(=O)N1CCN(c2ccc(NC(=O)COc3ccc(C)cc3)cc2)CC1,benzene_ring
200465,Modify the molecule COc1ccc2c(c1)[C@]1(CCN(C(=O)CC(C)C)C1)C(=O)N2 by removing a amide.,COc1ccc2c(c1)[C@]1(CCN(C(=O)CC(C)C)C1)C(=O)N2,amide
73855,Modify the molecule CC[NH+](CC)c1ccc(NC(=O)[C@H](C)Oc2ccc(C)cc2C)cc1 by removing a amide.,CC[NH+](CC)c1ccc(NC(=O)[C@H](C)Oc2ccc(C)cc2C)cc1,amide
6538,Modify the molecule CC[C@H](Cc1ccc(C)cc1)N(C)C(=O)Cc1nc2nc(C)cc(C)n2n1 by removing a amide.,CC[C@H](Cc1ccc(C)cc1)N(C)C(=O)Cc1nc2nc(C)cc(C)n2n1,amide
26912,Modify the molecule C[C@H]1CC(C(=O)N2CCCSc3ccc(Cl)cc32)C[C@@H](C)O1 by removing a amide.,C[C@H]1CC(C(=O)N2CCCSc3ccc(Cl)cc32)C[C@@H](C)O1,amide
81715,Modify the molecule CCS(=O)(=O)CCNC(=O)N[C@@H](c1ccccc1)c1ccccn1 by removing a benzene_ring.,CCS(=O)(=O)CCNC(=O)N[C@@H](c1ccccc1)c1ccccn1,benzene_ring
138847,Remove a amine from the molecule Nc1nc(CCNC(=O)c2ccc(C[NH+]3CCCCC3)cc2)cs1.,Nc1nc(CCNC(=O)c2ccc(C[NH+]3CCCCC3)cc2)cs1,amine
194256,Remove a benzene_ring from the molecule COc1ccc(C[NH+]2C[C@@H]3CC[C@H](C2)N(C(=O)c2oc(C)nc2C)C3)cc1.,COc1ccc(C[NH+]2C[C@@H]3CC[C@H](C2)N(C(=O)c2oc(C)nc2C)C3)cc1,benzene_ring
45504,Remove a benzene_ring from the molecule CCOc1cc(NCc2ccc(C(=O)OC)o2)ccc1C.,CCOc1cc(NCc2ccc(C(=O)OC)o2)ccc1C,benzene_ring
101414,Remove a nitro from the molecule CN(CCc1ccccc1Cl)c1ncc([N+](=O)[O-])s1.,CN(CCc1ccccc1Cl)c1ncc([N+](=O)[O-])s1,nitro
8747,Modify the molecule COc1ccc(NC(=O)[C@H]2[C@@H]3C(=O)N(c4cc(C)on4)C[C@]34C=C[C@H]2O4)cc1 by removing a benzene_ring.,COc1ccc(NC(=O)[C@H]2[C@@H]3C(=O)N(c4cc(C)on4)C[C@]34C=C[C@H]2O4)cc1,benzene_ring
239180,Remove a benzene_ring from the molecule CC(C)CCN(CC(=O)N1CCNCC1)C(=O)c1cccc(Cl)c1.,CC(C)CCN(CC(=O)N1CCNCC1)C(=O)c1cccc(Cl)c1,benzene_ring
68048,Please remove a benzene_ring from the molecule COc1cn(-c2ccccc2)nc1C(=O)OCC(=O)N1CCCCC1.,COc1cn(-c2ccccc2)nc1C(=O)OCC(=O)N1CCCCC1,benzene_ring
38874,Modify the molecule COc1ccc(C(=O)OCC(=O)NCc2cccc(C)c2)cc1 by removing a benzene_ring.,COc1ccc(C(=O)OCC(=O)NCc2cccc(C)c2)cc1,benzene_ring
137039,Remove a benzene_ring from the molecule CC1(CNC(=O)CNC(=O)c2ccc(F)c(F)c2)CCCC1.,CC1(CNC(=O)CNC(=O)c2ccc(F)c(F)c2)CCCC1,benzene_ring
135911,Remove a benzene_ring from the molecule Cc1ccccc1NC(=O)NCc1cn(-c2ccccc2)nc1-c1ccncc1.,Cc1ccccc1NC(=O)NCc1cn(-c2ccccc2)nc1-c1ccncc1,benzene_ring
13859,Modify the molecule CCc1cccc(C)c1NC(=O)NCC1CC1 by removing a benzene_ring.,CCc1cccc(C)c1NC(=O)NCC1CC1,benzene_ring
236810,Remove a benzene_ring from the molecule C[C@@H]1CCCCN1C(=O)NCc1ccc(F)c(Cl)c1.,C[C@@H]1CCCCN1C(=O)NCc1ccc(F)c(Cl)c1,benzene_ring
144829,Modify the molecule O=C(CCC(=O)N1CCC(c2nc3ccccc3s2)CC1)c1ccc2ccccc2c1 by removing a amide.,O=C(CCC(=O)N1CCC(c2nc3ccccc3s2)CC1)c1ccc2ccccc2c1,amide
191684,Please remove a amide from the molecule O=C(Cc1ccc2c(c1)OCO2)N1CCC[C@H]1c1nc(-c2ccccn2)no1.,O=C(Cc1ccc2c(c1)OCO2)N1CCC[C@H]1c1nc(-c2ccccn2)no1,amide
105797,Remove a benzene_ring from the molecule Cc1cccc(OCCn2cnc3ccc(Cl)cc3c2=O)c1.,Cc1cccc(OCCn2cnc3ccc(Cl)cc3c2=O)c1,benzene_ring
235339,Please remove a amide from the molecule O=C(CC1CCCCC1)NCc1nc2ccccc2[nH]1.,O=C(CC1CCCCC1)NCc1nc2ccccc2[nH]1,amide
21939,Remove a nitro from the molecule N#Cc1cc([N+](=O)[O-])ccc1Sc1nc(-c2ccccc2F)n[nH]1.,N#Cc1cc([N+](=O)[O-])ccc1Sc1nc(-c2ccccc2F)n[nH]1,nitro
96538,Remove a benzene_ring from the molecule CCOC(=O)c1cnc(-n2nc(C)cc2C)nc1Nc1ccc(C)c(C)c1.,CCOC(=O)c1cnc(-n2nc(C)cc2C)nc1Nc1ccc(C)c(C)c1,benzene_ring
204050,Please remove a benzene_ring from the molecule O=C1[C@@H]2ON(c3ccccc3)[C@@H](c3cccs3)[C@H]2C(=O)N1c1ccccc1.,O=C1[C@@H]2ON(c3ccccc3)[C@@H](c3cccs3)[C@H]2C(=O)N1c1ccccc1,benzene_ring
159839,Modify the molecule CCC[NH2+][C@](C)(CN1C[C@@H]2CCCC[NH+]2C[C@@H]1C)C(N)=O by removing a amide.,CCC[NH2+][C@](C)(CN1C[C@@H]2CCCC[NH+]2C[C@@H]1C)C(N)=O,amide
131690,Remove a halo from the molecule CC(=O)N1CCC([NH2+][C@H](CC(F)(F)F)c2ccc(F)cc2)CC1.,CC(=O)N1CCC([NH2+][C@H](CC(F)(F)F)c2ccc(F)cc2)CC1,halo
17245,Please remove a benzene_ring from the molecule COc1cccc(OC)c1C(=O)Nc1ccc(C(=O)NC[C@@H]2CCCO2)cc1.,COc1cccc(OC)c1C(=O)Nc1ccc(C(=O)NC[C@@H]2CCCO2)cc1,benzene_ring
217892,Modify the molecule Cc1noc(C)c1S(=O)(=O)N1CCC[C@@H](C(=O)Nc2ccc3ncn(C)c3c2)C1 by removing a amide.,Cc1noc(C)c1S(=O)(=O)N1CCC[C@@H](C(=O)Nc2ccc3ncn(C)c3c2)C1,amide
140597,Modify the molecule COc1ccc(Cl)c(NC(=O)[C@@H]2CC(O)=Nc3nncn32)c1 by removing a amide.,COc1ccc(Cl)c(NC(=O)[C@@H]2CC(O)=Nc3nncn32)c1,amide
181971,Remove a benzene_ring from the molecule COc1cc(OC)c(NS(=O)(=O)c2cc(C(=O)N3CCC3)ccc2C)cc1Cl.,COc1cc(OC)c(NS(=O)(=O)c2cc(C(=O)N3CCC3)ccc2C)cc1Cl,benzene_ring
242948,Modify the molecule CC[C@@H](NC(=O)NCCS(=O)(=O)C(C)(C)C)c1ccc(C)c(F)c1 by removing a halo.,CC[C@@H](NC(=O)NCCS(=O)(=O)C(C)(C)C)c1ccc(C)c(F)c1,halo
43857,Remove a amide from the molecule COc1ccc(OC)c(CN2CCN(C(=O)C[C@H](C)c3ccccc3)CC2)c1.,COc1ccc(OC)c(CN2CCN(C(=O)C[C@H](C)c3ccccc3)CC2)c1,amide
140570,Modify the molecule CC(=O)c1cccc(NC(=O)N2CCC[C@@H]2c2nnc3ccccn23)c1 by removing a benzene_ring.,CC(=O)c1cccc(NC(=O)N2CCC[C@@H]2c2nnc3ccccn23)c1,benzene_ring
126481,Please remove a benzene_ring from the molecule COCc1ccc(C(=O)Nc2nc(-c3cccc(C(F)(F)F)c3)cs2)cc1.,COCc1ccc(C(=O)Nc2nc(-c3cccc(C(F)(F)F)c3)cs2)cc1,benzene_ring
71990,Please remove a hydroxyl from the molecule Cc1cc(NC(=O)/C=C/c2ccco2)cc(C(=O)[O-])c1O.,Cc1cc(NC(=O)/C=C/c2ccco2)cc(C(=O)[O-])c1O,hydroxyl
79050,Modify the molecule CC(C)(NC(=O)[C@@H]1CCC(=O)N(C2CCCC2)C1)C12CC3CC(CC(C3)C1)C2 by removing a amide.,CC(C)(NC(=O)[C@@H]1CCC(=O)N(C2CCCC2)C1)C12CC3CC(CC(C3)C1)C2,amide
234522,Please remove a amide from the molecule NC(=O)c1ccc(C(=O)Oc2ccc(N3CCCC3)cc2)cn1.,NC(=O)c1ccc(C(=O)Oc2ccc(N3CCCC3)cc2)cn1,amide
46313,Modify the molecule Fc1cccc(Cl)c1CSC1=N[C@@H]2CCCC[C@@H]2N1 by removing a amine.,Fc1cccc(Cl)c1CSC1=N[C@@H]2CCCC[C@@H]2N1,amine
77890,Modify the molecule NC(=O)c1ccc(NC(=O)COC(=O)c2c3c(nc4ccccc24)/C(=C/c2ccc(O)cc2)CC3)cc1 by removing a benzene_ring.,NC(=O)c1ccc(NC(=O)COC(=O)c2c3c(nc4ccccc24)/C(=C/c2ccc(O)cc2)CC3)cc1,benzene_ring
25236,Modify the molecule C[C@H]1C[C@@H](C)CN(C(=O)C[NH+](CCC#N)CC(C)(C)C)C1 by removing a amide.,C[C@H]1C[C@@H](C)CN(C(=O)C[NH+](CCC#N)CC(C)(C)C)C1,amide
120649,Remove a benzene_ring from the molecule O=C(CCS(=O)(=O)c1ccccc1)N1CCN(c2nc3ccc(OC(F)(F)F)cc3s2)CC1.,O=C(CCS(=O)(=O)c1ccccc1)N1CCN(c2nc3ccc(OC(F)(F)F)cc3s2)CC1,benzene_ring
120257,Please remove a amide from the molecule CCOc1ccc(-n2ncc(C(=O)N[C@H]3CCCCC[C@H]3C(=O)OC)c2C)nn1.,CCOc1ccc(-n2ncc(C(=O)N[C@H]3CCCCC[C@H]3C(=O)OC)c2C)nn1,amide
99862,Modify the molecule C[C@H]1CC(NC(=O)CSc2nc([O-])c3cnn(-c4cccc(Cl)c4)c3n2)=NO1 by removing a halo.,C[C@H]1CC(NC(=O)CSc2nc([O-])c3cnn(-c4cccc(Cl)c4)c3n2)=NO1,halo
166553,Please remove a amide from the molecule CCN1C(=O)COc2ccc(C(=O)Cn3nnc4ccccc43)cc21.,CCN1C(=O)COc2ccc(C(=O)Cn3nnc4ccccc43)cc21,amide
162654,Modify the molecule O=C(CC[NH+]1CCN(c2ccccc2)CC1)NNC(=O)Nc1cccc(C(F)(F)F)c1 by removing a halo.,O=C(CC[NH+]1CCN(c2ccccc2)CC1)NNC(=O)Nc1cccc(C(F)(F)F)c1,halo
56360,Remove a amide from the molecule CCCC(=CC(=O)Nc1nccs1)CCC.,CCCC(=CC(=O)Nc1nccs1)CCC,amide
222333,Modify the molecule Cc1csc([C@H]2CCCCN2C(=O)[C@@H]2CCOc3ccccc32)n1 by removing a amide.,Cc1csc([C@H]2CCCCN2C(=O)[C@@H]2CCOc3ccccc32)n1,amide
56758,Please remove a halo from the molecule C[NH+](Cc1ccc(Br)cc1)Cc1nnc(-c2cccs2)o1.,C[NH+](Cc1ccc(Br)cc1)Cc1nnc(-c2cccs2)o1,halo
134573,Please remove a amide from the molecule O=C(c1ncccc1C(F)(F)F)N1CC[C@H](Oc2cccnc2)C1.,O=C(c1ncccc1C(F)(F)F)N1CC[C@H](Oc2cccnc2)C1,amide
78814,Remove a benzene_ring from the molecule COc1cc(/C=N/NC(=O)c2cccc(F)c2)c(Br)c(Br)c1O.,COc1cc(/C=N/NC(=O)c2cccc(F)c2)c(Br)c(Br)c1O,benzene_ring
74445,Modify the molecule CCC(CC)S(=O)(=O)/N=C(\[O-])[C@@H]1CCC[C@@H](C(F)(F)F)C1 by removing a halo.,CCC(CC)S(=O)(=O)/N=C(\[O-])[C@@H]1CCC[C@@H](C(F)(F)F)C1,halo
23483,Modify the molecule Cc1ccc(/C=C2\SC(S)=NC2=O)c(C)c1 by removing a benzene_ring.,Cc1ccc(/C=C2\SC(S)=NC2=O)c(C)c1,benzene_ring
48141,Remove a benzene_ring from the molecule Cc1ccccc1[C@@H](C)NC(=O)N1CCC(OCc2ccccc2F)CC1.,Cc1ccccc1[C@@H](C)NC(=O)N1CCC(OCc2ccccc2F)CC1,benzene_ring
33920,Please remove a amide from the molecule C=C1c2ccccc2C(=O)N1CCC(=O)N1CCc2ccccc21.,C=C1c2ccccc2C(=O)N1CCC(=O)N1CCc2ccccc21,amide
26892,Modify the molecule CC(C)CN1CCO[C@@H](CNC(=O)c2ccc[nH]c2=O)C1 by removing a amide.,CC(C)CN1CCO[C@@H](CNC(=O)c2ccc[nH]c2=O)C1,amide
156757,Remove a amide from the molecule CC1(NC(=O)c2cc3cc(F)ccc3oc2=O)Cc2ccccc2C1.,CC1(NC(=O)c2cc3cc(F)ccc3oc2=O)Cc2ccccc2C1,amide
132341,Modify the molecule CC(C)[NH+](CCC#N)[C@@H]1CCOC2(CCOCC2)C1 by removing a nitrile.,CC(C)[NH+](CCC#N)[C@@H]1CCOC2(CCOCC2)C1,nitrile
157944,Please remove a halo from the molecule O=C(c1ccc(CSc2nc3ccncc3n2Cc2ccccc2F)cc1)N1CCCCC1.,O=C(c1ccc(CSc2nc3ccncc3n2Cc2ccccc2F)cc1)N1CCCCC1,halo
8740,Remove a halo from the molecule Cc1nn(C)c(Cl)c1CS(=O)(=O)c1ccc([N+](=O)[O-])cc1.,Cc1nn(C)c(Cl)c1CS(=O)(=O)c1ccc([N+](=O)[O-])cc1,halo
33019,Modify the molecule C[NH+]1CCC(C(=O)N[C@@H]2CCCc3nc(-c4cccnc4)ncc32)CC1 by removing a amide.,C[NH+]1CCC(C(=O)N[C@@H]2CCCc3nc(-c4cccnc4)ncc32)CC1,amide
29719,Modify the molecule Cc1cc(-n2c(C)cc(/C=C/C(=O)N3CCC[C@@H]3c3ccccc3)c2C)no1 by removing a amide.,Cc1cc(-n2c(C)cc(/C=C/C(=O)N3CCC[C@@H]3c3ccccc3)c2C)no1,amide
164587,Remove a hydroxyl from the molecule COc1ccc2[nH]c3c(c2c1)CCN1C(=O)N([C@@H](C)/C(O)=N/C[C@H]2CCCO2)C(=O)[C@@]31C.,COc1ccc2[nH]c3c(c2c1)CCN1C(=O)N([C@@H](C)/C(O)=N/C[C@H]2CCCO2)C(=O)[C@@]31C,hydroxyl
162689,Please remove a amine from the molecule COc1ccc(Br)cc1CNc1cnccc1C#N.,COc1ccc(Br)cc1CNc1cnccc1C#N,amine
147011,Remove a halo from the molecule O=S(=O)(c1cccc(C(F)(F)F)c1)N(Cc1ccsc1)Cc1ccccn1.,O=S(=O)(c1cccc(C(F)(F)F)c1)N(Cc1ccsc1)Cc1ccccn1,halo
134445,Please remove a halo from the molecule Fc1ccc2c(c1)[C@@H]([NH2+]Cc1cccc(OCC(F)F)c1)CCO2.,Fc1ccc2c(c1)[C@@H]([NH2+]Cc1cccc(OCC(F)F)c1)CCO2,halo
188512,Modify the molecule CC[C@@H](C)NC(=O)[C@H]1CSCN1C(=O)Cc1ccc2c(c1)CCO2 by removing a amide.,CC[C@@H](C)NC(=O)[C@H]1CSCN1C(=O)Cc1ccc2c(c1)CCO2,amide
6751,Modify the molecule Cc1nc2ccc(N(C)C(=O)[C@@H](C)NC(=O)C(C)(C)C)cc2s1 by removing a amide.,Cc1nc2ccc(N(C)C(=O)[C@@H](C)NC(=O)C(C)(C)C)cc2s1,amide
148356,Remove a benzene_ring from the molecule COc1ccc(OC)c(C(=O)C[C@@H]2c3c(cc4c(c3OC)OCO4)CC[NH+]2C)c1.,COc1ccc(OC)c(C(=O)C[C@@H]2c3c(cc4c(c3OC)OCO4)CC[NH+]2C)c1,benzene_ring
35327,Modify the molecule Cc1ccc2c(CS/C(N)=[NH+]/C(C)(C)C)cc(=O)oc2c1 by removing a amine.,Cc1ccc2c(CS/C(N)=[NH+]/C(C)(C)C)cc(=O)oc2c1,amine
19604,Please remove a amide from the molecule Cc1cc(CNC(=O)c2ccc(-c3ccccc3)cc2)c(C)o1.,Cc1cc(CNC(=O)c2ccc(-c3ccccc3)cc2)c(C)o1,amide
72048,Modify the molecule CCn1nc(C)c(CNC(=O)Nc2ccc(OC(C)C)cc2C)c1C by removing a benzene_ring.,CCn1nc(C)c(CNC(=O)Nc2ccc(OC(C)C)cc2C)c1C,benzene_ring
53044,Please remove a halo from the molecule CC(C)NC(=O)[C@@H](C)N1CCc2onc(-c3ccc(C(F)(F)F)cc3)c2C1.,CC(C)NC(=O)[C@@H](C)N1CCc2onc(-c3ccc(C(F)(F)F)cc3)c2C1,halo
104304,Remove a benzene_ring from the molecule Cc1nn(CCCNC(=O)Nc2ccccc2C(F)(F)F)c(C)c1Br.,Cc1nn(CCCNC(=O)Nc2ccccc2C(F)(F)F)c(C)c1Br,benzene_ring
61747,Modify the molecule COC(=O)NC(C)(C)C(=O)NCC[C@H](O)c1ccccc1 by removing a benzene_ring.,COC(=O)NC(C)(C)C(=O)NCC[C@H](O)c1ccccc1,benzene_ring
149342,Please remove a amide from the molecule Cc1cccc(OC[C@@H](O)Cn2c([C@@H]3CC(=O)N(c4ccccc4C)C3)nc3ccccc32)c1.,Cc1cccc(OC[C@@H](O)Cn2c([C@@H]3CC(=O)N(c4ccccc4C)C3)nc3ccccc32)c1,amide
206596,Remove a amide from the molecule O=C(Cn1c(Cc2ccccc2)nn(-c2ccc(Cl)cc2)c1=O)NC1CCC1.,O=C(Cn1c(Cc2ccccc2)nn(-c2ccc(Cl)cc2)c1=O)NC1CCC1,amide
51886,Please remove a halo from the molecule O=C(Nc1cnc2ccccc2n1)c1cc2cc(F)ccc2oc1=O.,O=C(Nc1cnc2ccccc2n1)c1cc2cc(F)ccc2oc1=O,halo
120080,Remove a nitro from the molecule O=C(Nc1ccccc1)Nc1ccc(NC(=O)c2cccc([N+](=O)[O-])c2)cc1.,O=C(Nc1ccccc1)Nc1ccc(NC(=O)c2cccc([N+](=O)[O-])c2)cc1,nitro
186816,Modify the molecule Cc1ccc(/C([O-])=N/S(=O)(=O)c2ccc(C#N)cc2)cc1F by removing a halo.,Cc1ccc(/C([O-])=N/S(=O)(=O)c2ccc(C#N)cc2)cc1F,halo
66330,Remove a benzene_ring from the molecule Cc1ccc(NC(=S)N/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)cc1F.,Cc1ccc(NC(=S)N/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)cc1F,benzene_ring
166417,Remove a hydroxyl from the molecule COc1ccc(C[C@H](O)[C@@H]2CCCc3cccnc32)cc1.,COc1ccc(C[C@H](O)[C@@H]2CCCc3cccnc32)cc1,hydroxyl
212405,Please remove a amine from the molecule COc1ccnc(N[C@@H]2CCc3cc(N)ccc32)n1.,COc1ccnc(N[C@@H]2CCc3cc(N)ccc32)n1,amine
131279,Please remove a halo from the molecule Cc1nc(CN2CCN(c3ncc(Cl)cc3Cl)CC2)no1.,Cc1nc(CN2CCN(c3ncc(Cl)cc3Cl)CC2)no1,halo
76590,Remove a benzene_ring from the molecule COc1cc(C)c(C(=O)N2CCc3c([nH]c4ccccc34)C2)cc1OC.,COc1cc(C)c(C(=O)N2CCc3c([nH]c4ccccc34)C2)cc1OC,benzene_ring
227355,Please remove a nitro from the molecule Cc1cc(O)c(C[NH+]2C[C@@H](C)C[C@H](C)C2)c2c1C(=O)/C(=C\c1ccc([N+](=O)[O-])cc1)O2.,Cc1cc(O)c(C[NH+]2C[C@@H](C)C[C@H](C)C2)c2c1C(=O)/C(=C\c1ccc([N+](=O)[O-])cc1)O2,nitro
224844,Modify the molecule COc1ccc(C(=O)Nc2cccc3[nH]cnc23)cc1[N+](=O)[O-] by removing a amide.,COc1ccc(C(=O)Nc2cccc3[nH]cnc23)cc1[N+](=O)[O-],amide
99515,Remove a benzene_ring from the molecule CNc1ccc(/C=C/C(=O)c2ccc(SC)c(OC)c2)cc1[N+](=O)[O-].,CNc1ccc(/C=C/C(=O)c2ccc(SC)c(OC)c2)cc1[N+](=O)[O-],benzene_ring
217048,Modify the molecule CC(C)N(C)S(=O)(=O)N1CCN(CC(=O)N2CCCC[C@H]2C)CC1 by removing a amide.,CC(C)N(C)S(=O)(=O)N1CCN(CC(=O)N2CCCC[C@H]2C)CC1,amide
111443,Please remove a halo from the molecule C[C@@H]1C[C@H]1Nc1nc(Br)cn2ccnc12.,C[C@@H]1C[C@H]1Nc1nc(Br)cn2ccnc12,halo
206859,Modify the molecule CCC[C@@H](C)C(=O)Nc1cccc(NC(=O)c2ccco2)c1C by removing a benzene_ring.,CCC[C@@H](C)C(=O)Nc1cccc(NC(=O)c2ccco2)c1C,benzene_ring
51993,Modify the molecule O=C(c1ccn(COc2ccc(Br)cc2)n1)N1CCCCCC1 by removing a benzene_ring.,O=C(c1ccn(COc2ccc(Br)cc2)n1)N1CCCCCC1,benzene_ring
123719,Please remove a nitro from the molecule COc1ccc(/C=N/NC(=O)COc2ccccc2C)cc1[N+](=O)[O-].,COc1ccc(/C=N/NC(=O)COc2ccccc2C)cc1[N+](=O)[O-],nitro
247258,Please remove a amide from the molecule CC1CC[NH+](C[C@@H]2CCCN(C(=O)N[C@H](C)CC(=O)NC(C)C)C2)CC1.,CC1CC[NH+](C[C@@H]2CCCN(C(=O)N[C@H](C)CC(=O)NC(C)C)C2)CC1,amide
177877,Remove a benzene_ring from the molecule COc1ccc(F)cc1CSCc1nc(CC(C)C)no1.,COc1ccc(F)cc1CSCc1nc(CC(C)C)no1,benzene_ring
99225,Remove a halo from the molecule Cc1c([O-])nc(SCC(=O)Nc2nccs2)n(-c2ccc(F)cc2)c1=O.,Cc1c([O-])nc(SCC(=O)Nc2nccs2)n(-c2ccc(F)cc2)c1=O,halo
136498,Remove a halo from the molecule N[C@]1(C(=O)[O-])CC[C@@H]([NH+]2CCC(C(F)(F)F)CC2)C1.,N[C@]1(C(=O)[O-])CC[C@@H]([NH+]2CCC(C(F)(F)F)CC2)C1,halo
74675,Remove a amide from the molecule CC1(C)c2[nH]c3ccccc3c2C[C@@H]2C(=O)N(C3CCCC3)CC(=O)N21.,CC1(C)c2[nH]c3ccccc3c2C[C@@H]2C(=O)N(C3CCCC3)CC(=O)N21,amide
185507,Please remove a benzene_ring from the molecule COc1ccccc1[C@@H](NC(=O)/C=C/c1cnn(C)c1C)c1ccccn1.,COc1ccccc1[C@@H](NC(=O)/C=C/c1cnn(C)c1C)c1ccccn1,benzene_ring
96474,Remove a benzene_ring from the molecule O=C(/C=C/c1ccc2c(c1)OCO2)NNC(=O)c1nn(Cc2ccccc2)c(=O)c2ccccc12.,O=C(/C=C/c1ccc2c(c1)OCO2)NNC(=O)c1nn(Cc2ccccc2)c(=O)c2ccccc12,benzene_ring
24339,Modify the molecule CS(=O)(=O)c1ccc(CC(=O)Nc2ccccc2C2[NH+]=c3ccccc3=[NH+]2)cc1 by removing a benzene_ring.,CS(=O)(=O)c1ccc(CC(=O)Nc2ccccc2C2[NH+]=c3ccccc3=[NH+]2)cc1,benzene_ring
120026,Modify the molecule C=Cc1c(C)nn(-c2ccccc2)c1C by removing a benzene_ring.,C=Cc1c(C)nn(-c2ccccc2)c1C,benzene_ring
127469,Please remove a halo from the molecule CCn1c2ccccc2c2cc(NC(=O)c3ccc(F)c(S(=O)(=O)N4CCOCC4)c3)ccc21.,CCn1c2ccccc2c2cc(NC(=O)c3ccc(F)c(S(=O)(=O)N4CCOCC4)c3)ccc21,halo
168412,Remove a hydroxyl from the molecule O=C(c1ccccc1Cl)N1N=C(C(F)(F)F)C[C@@]1(O)C1CCCCC1.,O=C(c1ccccc1Cl)N1N=C(C(F)(F)F)C[C@@]1(O)C1CCCCC1,hydroxyl
95587,Please remove a benzene_ring from the molecule Cc1ccccc1[C@H]1C[C@@H]1C(=O)N1CCC(n2cncn2)CC1.,Cc1ccccc1[C@H]1C[C@@H]1C(=O)N1CCC(n2cncn2)CC1,benzene_ring
31082,Remove a benzene_ring from the molecule COCCN(Cc1ccccn1)C(=O)[C@H]1C[C@H]1c1ccccc1C.,COCCN(Cc1ccccn1)C(=O)[C@H]1C[C@H]1c1ccccc1C,benzene_ring
16087,Modify the molecule CCc1cccc2c1=[NH+]CC=2/C=C(\C#N)c1nc2ccccc2[nH]1 by removing a amine.,CCc1cccc2c1=[NH+]CC=2/C=C(\C#N)c1nc2ccccc2[nH]1,amine
220779,Modify the molecule CCOC(=O)c1c(C2CC2)csc1NC(=O)/C=C/c1ccc(C)o1 by removing a amide.,CCOC(=O)c1c(C2CC2)csc1NC(=O)/C=C/c1ccc(C)o1,amide
88187,Please remove a halo from the molecule Cc1cc(NC(=O)c2ccc(/C=C3\SC(=O)N(c4cccc(C(F)(F)F)c4)C3=O)cc2)no1.,Cc1cc(NC(=O)c2ccc(/C=C3\SC(=O)N(c4cccc(C(F)(F)F)c4)C3=O)cc2)no1,halo
175410,Please remove a benzene_ring from the molecule O=[N+]([O-])c1cccc2c1N[C@H](c1cccc(Cl)c1)[C@@H]1CC=C[C@@H]21.,O=[N+]([O-])c1cccc2c1N[C@H](c1cccc(Cl)c1)[C@@H]1CC=C[C@@H]21,benzene_ring
201619,Modify the molecule Cc1ccsc1CNC(=O)CSc1ncn[nH]1 by removing a amide.,Cc1ccsc1CNC(=O)CSc1ncn[nH]1,amide
94561,Please remove a amide from the molecule O=C1C[C@@H](C(=O)NC[C@H]2CCCN(c3ncccn3)C2)c2ccc(F)cc2N1.,O=C1C[C@@H](C(=O)NC[C@H]2CCCN(c3ncccn3)C2)c2ccc(F)cc2N1,amide
234008,Modify the molecule COC(=O)c1ncn2c1C(=O)N(c1ccc(C)c(F)c1)[C@](C)(C(=O)NCc1ccccc1OC)C2 by removing a benzene_ring.,COC(=O)c1ncn2c1C(=O)N(c1ccc(C)c(F)c1)[C@](C)(C(=O)NCc1ccccc1OC)C2,benzene_ring
87327,Remove a nitro from the molecule C[C@@H]1CN(C(=O)Cn2cc([N+](=O)[O-])cn2)C[C@@H](C)O1.,C[C@@H]1CN(C(=O)Cn2cc([N+](=O)[O-])cn2)C[C@@H](C)O1,nitro
150068,Modify the molecule COc1ccc([C@@H]2C[C@@H](C)N(c3cccc[nH+]3)C2)cc1 by removing a benzene_ring.,COc1ccc([C@@H]2C[C@@H](C)N(c3cccc[nH+]3)C2)cc1,benzene_ring
145987,Remove a benzene_ring from the molecule CCC[C@H](C)NC(=O)[C@H](C)Nc1c(C)nn(-c2ccccc2)c1C.,CCC[C@H](C)NC(=O)[C@H](C)Nc1c(C)nn(-c2ccccc2)c1C,benzene_ring
30138,Modify the molecule O=C(CSc1ncnc2sc3c(c12)CCCC3)NC[C@@H]1CCCO1 by removing a amide.,O=C(CSc1ncnc2sc3c(c12)CCCC3)NC[C@@H]1CCCO1,amide
22525,Please remove a amide from the molecule C[C@@H]1COC[C@@H](C)N1C(=O)CSc1nnnn1C.,C[C@@H]1COC[C@@H](C)N1C(=O)CSc1nnnn1C,amide
81971,Please remove a halo from the molecule C[C@H](NC(=O)c1ccccc1I)c1ccc(Br)cc1.,C[C@H](NC(=O)c1ccccc1I)c1ccc(Br)cc1,halo
178196,Please remove a thiol from the molecule SCC1(CSc2nncs2)CC1.,SCC1(CSc2nncs2)CC1,thiol
181321,Modify the molecule O=C([O-])[C@H]1CCN(c2ccc(F)cc2)[C@@H]1c1ccc(C(F)(F)F)cc1 by removing a benzene_ring.,O=C([O-])[C@H]1CCN(c2ccc(F)cc2)[C@@H]1c1ccc(C(F)(F)F)cc1,benzene_ring
157199,Modify the molecule CSc1ccc(NC(=O)N(C)[C@H](C)c2nc(C)sc2C)cc1 by removing a benzene_ring.,CSc1ccc(NC(=O)N(C)[C@H](C)c2nc(C)sc2C)cc1,benzene_ring
206848,Remove a benzene_ring from the molecule COc1ccc(NC(=O)[C@H](C)Sc2cccc(F)c2)cc1OC.,COc1ccc(NC(=O)[C@H](C)Sc2cccc(F)c2)cc1OC,benzene_ring
43377,Remove a hydroxyl from the molecule CCCC1CCC(C[NH3+])([C@@H](O)c2cccs2)CC1.,CCCC1CCC(C[NH3+])([C@@H](O)c2cccs2)CC1,hydroxyl
4449,Modify the molecule Cc1nn(C)c2nc(NC[C@H](c3ccncc3)N3CCOCC3)sc12 by removing a amine.,Cc1nn(C)c2nc(NC[C@H](c3ccncc3)N3CCOCC3)sc12,amine
241759,Remove a benzene_ring from the molecule O=S(=O)(NCCCn1ccnc1-c1ccccc1)c1cccs1.,O=S(=O)(NCCCn1ccnc1-c1ccccc1)c1cccs1,benzene_ring
198348,Please remove a benzene_ring from the molecule Cc1c(C(=O)Nc2cccc(COCC3CC3)c2)cnn1-c1ccncc1.,Cc1c(C(=O)Nc2cccc(COCC3CC3)c2)cnn1-c1ccncc1,benzene_ring
222008,Remove a benzene_ring from the molecule COc1cccc(C(=O)N/N=C\c2ccc(Sc3cccc4cccnc34)o2)c1.,COc1cccc(C(=O)N/N=C\c2ccc(Sc3cccc4cccnc34)o2)c1,benzene_ring
231015,Modify the molecule C[C@@H]1CC[NH+](Cc2ccc([N+](=O)[O-])c(O)c2)C[C@@H]1C by removing a nitro.,C[C@@H]1CC[NH+](Cc2ccc([N+](=O)[O-])c(O)c2)C[C@@H]1C,nitro
240544,Please remove a amide from the molecule O=C(Nc1ccc(Br)cc1)c1cccnc1NCc1ccccc1.,O=C(Nc1ccc(Br)cc1)c1cccnc1NCc1ccccc1,amide
41223,Please remove a nitro from the molecule COc1cc(/C(C#N)=C/c2cccc3c2OCCCO3)ccc1[N+](=O)[O-].,COc1cc(/C(C#N)=C/c2cccc3c2OCCCO3)ccc1[N+](=O)[O-],nitro
191245,Please remove a benzene_ring from the molecule CC(C)Cc1noc(C[NH2+][C@H](C)c2ccc(Cl)cc2Cl)n1.,CC(C)Cc1noc(C[NH2+][C@H](C)c2ccc(Cl)cc2Cl)n1,benzene_ring
201795,Please remove a benzene_ring from the molecule Cc1ccccc1C(=O)Nc1cccc(C(=O)N2CCC[C@@H]2C(=O)NCCc2ccccc2)c1.,Cc1ccccc1C(=O)Nc1cccc(C(=O)N2CCC[C@@H]2C(=O)NCCc2ccccc2)c1,benzene_ring
195391,Remove a halo from the molecule CC(C)c1cc(C(=O)NCCNC(=O)c2ccc(Cl)cc2)n(C)n1.,CC(C)c1cc(C(=O)NCCNC(=O)c2ccc(Cl)cc2)n(C)n1,halo
138102,Modify the molecule COc1ccc([C@H]2CC(O)=Nc3c2c(=O)[nH]n3C(C)C)c(OC)c1OC by removing a hydroxyl.,COc1ccc([C@H]2CC(O)=Nc3c2c(=O)[nH]n3C(C)C)c(OC)c1OC,hydroxyl
72891,Remove a amide from the molecule C[C@@H](Sc1ncc2ccccn12)C(=O)N(Cc1ccccc1)Cc1ccccc1.,C[C@@H](Sc1ncc2ccccn12)C(=O)N(Cc1ccccc1)Cc1ccccc1,amide
217739,Please remove a benzene_ring from the molecule CC[C@@](C)([NH3+])C(=O)NC[C@H](c1ccccc1)[NH+]1CCCC1.,CC[C@@](C)([NH3+])C(=O)NC[C@H](c1ccccc1)[NH+]1CCCC1,benzene_ring
18702,Remove a benzene_ring from the molecule CCOc1ccc(N2C(=O)C[C@H](SCC(=O)Nc3cccc(Cl)c3C)C2=O)cc1.,CCOc1ccc(N2C(=O)C[C@H](SCC(=O)Nc3cccc(Cl)c3C)C2=O)cc1,benzene_ring
9587,Remove a amide from the molecule CCS(=O)(=O)C[C@@H](C)NC(=O)c1ccc(OC(F)F)cc1.,CCS(=O)(=O)C[C@@H](C)NC(=O)c1ccc(OC(F)F)cc1,amide
50578,Modify the molecule C[C@@H](OC(=O)c1ccc(CC#N)cc1)c1nc2ccc(Cl)cc2n1C by removing a halo.,C[C@@H](OC(=O)c1ccc(CC#N)cc1)c1nc2ccc(Cl)cc2n1C,halo
54671,Please remove a amide from the molecule CC1=C(C(=O)Nc2cc(C)ccn2)[C@H](c2cc([N+](=O)[O-])ccc2Cl)C2=C(CC(C)(C)CC2=O)N1.,CC1=C(C(=O)Nc2cc(C)ccn2)[C@H](c2cc([N+](=O)[O-])ccc2Cl)C2=C(CC(C)(C)CC2=O)N1,amide
238362,Remove a amide from the molecule CCN[C@]1(C(N)=O)CC[C@H]([NH+]2CCC(C)(C)C2)C1.,CCN[C@]1(C(N)=O)CC[C@H]([NH+]2CCC(C)(C)C2)C1,amide
24962,Remove a hydroxyl from the molecule CC(C)(C)C[C@H](CO)NC(=O)c1cccnc1Br.,CC(C)(C)C[C@H](CO)NC(=O)c1cccnc1Br,hydroxyl
178092,Remove a amide from the molecule CC[NH+]1CC[C@H](N(C)C(=O)c2cccc(-n3cccn3)c2)[C@H](C)C1.,CC[NH+]1CC[C@H](N(C)C(=O)c2cccc(-n3cccn3)c2)[C@H](C)C1,amide
176787,Remove a benzene_ring from the molecule Cc1ccc(O)c(C(=O)Nc2cccc(I)c2)c1.,Cc1ccc(O)c(C(=O)Nc2cccc(I)c2)c1,benzene_ring
163983,Modify the molecule COc1ccc(C(=O)CSc2nc3ccccc3nc2-c2ccccc2)cc1OC by removing a benzene_ring.,COc1ccc(C(=O)CSc2nc3ccccc3nc2-c2ccccc2)cc1OC,benzene_ring
155145,Please remove a amide from the molecule C[C@H](C(N)=O)N1CC[NH+](Cc2ccc3c(c2)CC(C)(C)O3)CC1.,C[C@H](C(N)=O)N1CC[NH+](Cc2ccc3c(c2)CC(C)(C)O3)CC1,amide
205206,Please remove a amide from the molecule Cc1nc2cc(NC(=O)C(=O)NCC3(C)CCC3)ccc2o1.,Cc1nc2cc(NC(=O)C(=O)NCC3(C)CCC3)ccc2o1,amide
22896,Remove a benzene_ring from the molecule CC(C)(C)OC(=O)N1CCC(COc2ccc(OC(F)(F)F)cc2)CC1.,CC(C)(C)OC(=O)N1CCC(COc2ccc(OC(F)(F)F)cc2)CC1,benzene_ring
225345,Remove a benzene_ring from the molecule COc1cccc(CN(C(C)=O)c2c(C)nc3ccccn23)c1OC.,COc1cccc(CN(C(C)=O)c2c(C)nc3ccccn23)c1OC,benzene_ring
172373,Remove a halo from the molecule [NH3+][C@@H](Cc1ccc(F)c(F)c1)c1ccc(F)cc1Br.,[NH3+][C@@H](Cc1ccc(F)c(F)c1)c1ccc(F)cc1Br,halo
16047,Please remove a halo from the molecule O=C(COc1ccccc1-c1noc(-c2ccc(Cl)cc2)n1)N1CCCC1.,O=C(COc1ccccc1-c1noc(-c2ccc(Cl)cc2)n1)N1CCCC1,halo
53496,Remove a amide from the molecule O=C(Nc1ccc(Br)cc1C(=O)[O-])c1ccc(Br)s1.,O=C(Nc1ccc(Br)cc1C(=O)[O-])c1ccc(Br)s1,amide
88389,Please remove a nitro from the molecule COc1ccc(COc2ccc(CO)cc2)cc1[N+](=O)[O-].,COc1ccc(COc2ccc(CO)cc2)cc1[N+](=O)[O-],nitro
4743,Please remove a amide from the molecule CCCn1c(C)cc(-c2csc(NC(=O)c3scnc3C)n2)c1C.,CCCn1c(C)cc(-c2csc(NC(=O)c3scnc3C)n2)c1C,amide
5096,Please remove a benzene_ring from the molecule O=C(Nc1cccc2cnccc12)N(Cc1ccccc1F)C1CC1.,O=C(Nc1cccc2cnccc12)N(Cc1ccccc1F)C1CC1,benzene_ring
223862,Remove a benzene_ring from the molecule Cc1ccccc1[C@@H]1CC(=O)C2=C(C1)Nc1ncnn1[C@@H]2c1ccc(F)cc1.,Cc1ccccc1[C@@H]1CC(=O)C2=C(C1)Nc1ncnn1[C@@H]2c1ccc(F)cc1,benzene_ring
10616,Modify the molecule FC(F)(F)c1cnn(-c2nc(Br)cs2)c1 by removing a halo.,FC(F)(F)c1cnn(-c2nc(Br)cs2)c1,halo
53668,Please remove a amide from the molecule Cc1c([C@@H]2c3ccccc3C(=O)N2CC(=O)Nc2cccnc2)c2ccccc2n1C.,Cc1c([C@@H]2c3ccccc3C(=O)N2CC(=O)Nc2cccnc2)c2ccccc2n1C,amide
41909,Please remove a benzene_ring from the molecule O=C(CSc1cc(-c2ccccc2)ncn1)N1CCCC1.,O=C(CSc1cc(-c2ccccc2)ncn1)N1CCCC1,benzene_ring
57020,Modify the molecule C[C@@H](NC(=O)[C@@H]1CCCO1)c1cccs1 by removing a amide.,C[C@@H](NC(=O)[C@@H]1CCCO1)c1cccs1,amide
91042,Modify the molecule C[C@H](CNC(=O)c1cccc2[nH]ccc12)[NH+]1CCCC1 by removing a amide.,C[C@H](CNC(=O)c1cccc2[nH]ccc12)[NH+]1CCCC1,amide
240691,Modify the molecule C[C@@H](c1ccccc1)N(C)C(=O)C[NH+]1CCCC[C@@H]1C(=O)N1CCOCC1 by removing a amide.,C[C@@H](c1ccccc1)N(C)C(=O)C[NH+]1CCCC[C@@H]1C(=O)N1CCOCC1,amide
85564,Please remove a halo from the molecule CN(CC(=O)OCC(=O)c1ccc(Cl)s1)c1ncccn1.,CN(CC(=O)OCC(=O)c1ccc(Cl)s1)c1ncccn1,halo
215683,Remove a amide from the molecule Cc1cc([N-]S(=O)(=O)c2ccc3c(c2)CN(C(=O)C(C)(C)C)CC3)no1.,Cc1cc([N-]S(=O)(=O)c2ccc3c(c2)CN(C(=O)C(C)(C)C)CC3)no1,amide
81232,Remove a benzene_ring from the molecule Cc1ncccc1NC(=O)/C=C(/c1ccccc1)C(F)(F)F.,Cc1ncccc1NC(=O)/C=C(/c1ccccc1)C(F)(F)F,benzene_ring
181265,Please remove a benzene_ring from the molecule Cc1ccc([S@@](=O)/N=C/c2ccc(F)cc2)cc1.,Cc1ccc([S@@](=O)/N=C/c2ccc(F)cc2)cc1,benzene_ring
37108,Modify the molecule O=C(NCc1cccnc1OCC(F)(F)F)c1ccc2[nH]cnc2c1 by removing a amide.,O=C(NCc1cccnc1OCC(F)(F)F)c1ccc2[nH]cnc2c1,amide
162717,Please remove a benzene_ring from the molecule CCc1ccc(Oc2nc3ccccn3c(=O)c2/C=C2/SC(=S)N(C[C@@H]3CCCO3)C2=O)cc1.,CCc1ccc(Oc2nc3ccccn3c(=O)c2/C=C2/SC(=S)N(C[C@@H]3CCCO3)C2=O)cc1,benzene_ring
234858,Remove a benzene_ring from the molecule CC(C)(C)n1cc(NC(=O)N[C@H]2C[C@H]2c2ccccc2)cn1.,CC(C)(C)n1cc(NC(=O)N[C@H]2C[C@H]2c2ccccc2)cn1,benzene_ring
239725,Remove a halo from the molecule NC(=O)c1ccc(NCc2cccc(Br)c2)nn1.,NC(=O)c1ccc(NCc2cccc(Br)c2)nn1,halo
137377,Modify the molecule CC(=O)Nc1ccc(S(=O)(=O)N2CCC(Oc3nc4c(C)cccc4s3)CC2)cc1 by removing a amide.,CC(=O)Nc1ccc(S(=O)(=O)N2CCC(Oc3nc4c(C)cccc4s3)CC2)cc1,amide
45404,Remove a benzene_ring from the molecule CC[C@H](C)c1ccc([C@@H](O)c2cscc2C)cc1.,CC[C@H](C)c1ccc([C@@H](O)c2cscc2C)cc1,benzene_ring
20985,Please remove a amide from the molecule COc1nccnc1N1CCC[C@@H](N2CCCC2=O)C1.,COc1nccnc1N1CCC[C@@H](N2CCCC2=O)C1,amide
12028,Modify the molecule Cc1cc(-n2cncn2)ccc1C(=O)Nc1c(C)cccc1Cl by removing a benzene_ring.,Cc1cc(-n2cncn2)ccc1C(=O)Nc1c(C)cccc1Cl,benzene_ring
94487,Please remove a benzene_ring from the molecule Cc1c(Cl)cccc1-n1ccnc1S[C@@H](C)C(=O)NC(C)(C)C.,Cc1c(Cl)cccc1-n1ccnc1S[C@@H](C)C(=O)NC(C)(C)C,benzene_ring
113918,Remove a benzene_ring from the molecule Cc1csc(N(C(=O)/C=C/c2ccccc2)c2ccccc2)n1.,Cc1csc(N(C(=O)/C=C/c2ccccc2)c2ccccc2)n1,benzene_ring
248221,Please remove a amide from the molecule CCOC(=O)C1CCN(C(=O)COC(=O)c2n[nH]c3ccccc23)CC1.,CCOC(=O)C1CCN(C(=O)COC(=O)c2n[nH]c3ccccc23)CC1,amide
125324,Please remove a amide from the molecule COc1ccc(C)c2sc(N(CC[NH+](C)C)C(=O)c3snnc3C)nc12.,COc1ccc(C)c2sc(N(CC[NH+](C)C)C(=O)c3snnc3C)nc12,amide
175387,Modify the molecule Cc1cc(C)c(C)c(S(=O)(=O)Nc2ccc3c(c2)CN(C(=O)c2cccs2)CC3)c1C by removing a benzene_ring.,Cc1cc(C)c(C)c(S(=O)(=O)Nc2ccc3c(c2)CN(C(=O)c2cccs2)CC3)c1C,benzene_ring
4492,Modify the molecule COC(=O)c1ccc(F)c(NC(=O)c2cccnc2SC)c1 by removing a halo.,COC(=O)c1ccc(F)c(NC(=O)c2cccnc2SC)c1,halo
176475,Modify the molecule COCCN1C(=O)C(C#N)=C(C)/C(=C/c2ccc(OC)cc2OC)C1=O by removing a benzene_ring.,COCCN1C(=O)C(C#N)=C(C)/C(=C/c2ccc(OC)cc2OC)C1=O,benzene_ring
59050,Please remove a benzene_ring from the molecule CC(=O)N[C@@H]1CCCN(C(=O)c2cccc(N[C@@H](C)C(C)C)c2C)C1.,CC(=O)N[C@@H]1CCCN(C(=O)c2cccc(N[C@@H](C)C(C)C)c2C)C1,benzene_ring
92660,Please remove a halo from the molecule Cc1c(C(=O)N(C)c2ccccc2Cl)oc2c1/C(=N/O)CC(C)(C)C2.,Cc1c(C(=O)N(C)c2ccccc2Cl)oc2c1/C(=N/O)CC(C)(C)C2,halo
179331,Modify the molecule COc1cccc([C@@H]2CN(C(=O)CSc3nc(C)n[nH]3)C[C@H]2C(=O)[O-])c1 by removing a amide.,COc1cccc([C@@H]2CN(C(=O)CSc3nc(C)n[nH]3)C[C@H]2C(=O)[O-])c1,amide
141136,Modify the molecule O=C(Nc1ccc(NC(=O)[C@@H](O)c2ccccc2)cc1)C1CC1 by removing a benzene_ring.,O=C(Nc1ccc(NC(=O)[C@@H](O)c2ccccc2)cc1)C1CC1,benzene_ring
235427,Please remove a halo from the molecule O=C(C1=C([O-])C(=O)N(Cc2cccnc2)[C@H]1c1ccc(Cl)cc1)c1cccs1.,O=C(C1=C([O-])C(=O)N(Cc2cccnc2)[C@H]1c1ccc(Cl)cc1)c1cccs1,halo
168113,Modify the molecule CCOCC[NH+](C)[C@H](C)C(=O)N1CCC(C(N)=O)CC1 by removing a amide.,CCOCC[NH+](C)[C@H](C)C(=O)N1CCC(C(N)=O)CC1,amide
25719,Modify the molecule C[C@@H](NC(=O)[C@@H](O)c1ccccc1)c1cccc(N2CCOC2=O)c1 by removing a benzene_ring.,C[C@@H](NC(=O)[C@@H](O)c1ccccc1)c1cccc(N2CCOC2=O)c1,benzene_ring
22846,Please remove a benzene_ring from the molecule CCCc1nccn1-c1cccc([C@@H](C)[NH2+]CC)c1.,CCCc1nccn1-c1cccc([C@@H](C)[NH2+]CC)c1,benzene_ring
242163,Remove a halo from the molecule CCCC(=O)Nc1nnc(CC(=O)N/N=C/c2ccccc2Cl)s1.,CCCC(=O)Nc1nnc(CC(=O)N/N=C/c2ccccc2Cl)s1,halo
162140,Modify the molecule COc1ccc(/C=N/N=C2\NC(=O)[C@@H](Cc3cccc(Cl)c3)S2)cc1 by removing a benzene_ring.,COc1ccc(/C=N/N=C2\NC(=O)[C@@H](Cc3cccc(Cl)c3)S2)cc1,benzene_ring
160016,Please remove a amide from the molecule C[C@@H](C(=O)NCCC1=CCCCC1)N1CCn2c(nnc2C2CC2)C1.,C[C@@H](C(=O)NCCC1=CCCCC1)N1CCn2c(nnc2C2CC2)C1,amide
114019,Modify the molecule CCOc1ccc(S(=O)(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)cc1Br by removing a amine.,CCOc1ccc(S(=O)(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)cc1Br,amine
184085,Please remove a nitrile from the molecule CCCCN(C)C(=O)C1CC[NH+](Cc2cn3ccccc3c2C#N)CC1.,CCCCN(C)C(=O)C1CC[NH+](Cc2cn3ccccc3c2C#N)CC1,nitrile
232933,Please remove a amide from the molecule Cn1c(=O)[nH]c2cc(C(=O)N[C@@H]3c4ccccc4C[C@@H]3O)ccc21.,Cn1c(=O)[nH]c2cc(C(=O)N[C@@H]3c4ccccc4C[C@@H]3O)ccc21,amide
223588,Remove a amide from the molecule C[C@H]1C[C@@H](c2ccc(F)cc2)C[NH+]1CC(=O)NNC(=O)C1CCC1.,C[C@H]1C[C@@H](c2ccc(F)cc2)C[NH+]1CC(=O)NNC(=O)C1CCC1,amide
41585,Remove a hydroxyl from the molecule CC(C)(O)CSCCNC(=O)N1CC[C@@H]2CCCC[C@@H]21.,CC(C)(O)CSCCNC(=O)N1CC[C@@H]2CCCC[C@@H]21,hydroxyl
141738,Please remove a halo from the molecule CCNC(=O)c1ccc(Cl)cc1NC(=O)[C@@H]1C[C@@H]1C.,CCNC(=O)c1ccc(Cl)cc1NC(=O)[C@@H]1C[C@@H]1C,halo
16029,Remove a halo from the molecule O=C(Cc1ccc(Cl)cc1)N1CCN(CC(F)(F)F)CC1.,O=C(Cc1ccc(Cl)cc1)N1CCN(CC(F)(F)F)CC1,halo
29711,Please remove a amine from the molecule COC(=O)[C@@H](N)C12CC3CC(CC(C3)C1)C2.,COC(=O)[C@@H](N)C12CC3CC(CC(C3)C1)C2,amine
47198,Remove a amide from the molecule Nc1ccc(Oc2ccc3c(c2)C(=O)N(Cc2cccnc2)C3=O)cc1.,Nc1ccc(Oc2ccc3c(c2)C(=O)N(Cc2cccnc2)C3=O)cc1,amide
188749,Please remove a amine from the molecule O=C([O-])CSC(=S)Nc1ccccn1.,O=C([O-])CSC(=S)Nc1ccccn1,amine
47787,Modify the molecule CC(=O)c1cccc(NC(=O)[C@@H](C)n2c(=O)cc(C)c3cc(C)cc(C)c32)c1 by removing a amide.,CC(=O)c1cccc(NC(=O)[C@@H](C)n2c(=O)cc(C)c3cc(C)cc(C)c32)c1,amide
9008,Please remove a amide from the molecule C[C@H]1CN(CC(=O)N(CCC(N)=O)c2ccc(F)cc2)C(C)(C)CO1.,C[C@H]1CN(CC(=O)N(CCC(N)=O)c2ccc(F)cc2)C(C)(C)CO1,amide
5876,Remove a benzene_ring from the molecule COc1ccc(N2CCN([C@H]3CCC[NH+](Cc4[nH]c5ccccc5c4C)C3)CC2)cc1.,COc1ccc(N2CCN([C@H]3CCC[NH+](Cc4[nH]c5ccccc5c4C)C3)CC2)cc1,benzene_ring
107964,Please remove a amide from the molecule CN(C)C(=S)SCC(=O)N1c2ccccc2NC(=O)C1(C)C.,CN(C)C(=S)SCC(=O)N1c2ccccc2NC(=O)C1(C)C,amide
221656,Modify the molecule Cc1ncn(-c2cc(N3CCN(C(=O)Cc4ccccc4)CC3)ncn2)c1C by removing a amide.,Cc1ncn(-c2cc(N3CCN(C(=O)Cc4ccccc4)CC3)ncn2)c1C,amide
48533,Remove a benzene_ring from the molecule Cc1cccc(Nc2nc3nccc(-c4cccs4)c3c(=O)[nH]2)c1.,Cc1cccc(Nc2nc3nccc(-c4cccs4)c3c(=O)[nH]2)c1,benzene_ring
179993,Remove a hydroxyl from the molecule COC(=O)C(C)(C)Cn1ccc([C@H](C)O)c1.,COC(=O)C(C)(C)Cn1ccc([C@H](C)O)c1,hydroxyl
237163,Modify the molecule CCOc1ccc(N2C(=O)[C@@H](C)S/C2=C(\C#N)C(=O)N[C@H](C)c2ccccc2)cc1 by removing a benzene_ring.,CCOc1ccc(N2C(=O)[C@@H](C)S/C2=C(\C#N)C(=O)N[C@H](C)c2ccccc2)cc1,benzene_ring
240650,Please remove a benzene_ring from the molecule COc1cc(C[NH+]2CC[C@@H](NC(=O)c3ccn(C(C)C)n3)C2)cc(OC)c1.,COc1cc(C[NH+]2CC[C@@H](NC(=O)c3ccn(C(C)C)n3)C2)cc(OC)c1,benzene_ring
66118,Remove a nitro from the molecule Cn1ccc(Nc2ccncc2[N+](=O)[O-])n1.,Cn1ccc(Nc2ccncc2[N+](=O)[O-])n1,nitro
247386,Modify the molecule CCCCCC(C)(C)CNc1ncnc2[nH]cnc12 by removing a amine.,CCCCCC(C)(C)CNc1ncnc2[nH]cnc12,amine
103041,Modify the molecule CO[C@H]1CCC[C@@H]1OC(=O)CCCNC(C)=O by removing a amide.,CO[C@H]1CCC[C@@H]1OC(=O)CCCNC(C)=O,amide
216337,Please remove a halo from the molecule CCCn1c(=O)c2ccc(Cl)cc2n2c(SCC(=O)Nc3cccc(C)c3)nnc12.,CCCn1c(=O)c2ccc(Cl)cc2n2c(SCC(=O)Nc3cccc(C)c3)nnc12,halo
190013,Modify the molecule Cc1ccccc1NC(=O)NNC(=O)c1cccc(NC(=O)C2CCCCC2)c1 by removing a amide.,Cc1ccccc1NC(=O)NNC(=O)c1cccc(NC(=O)C2CCCCC2)c1,amide
227896,Please remove a amide from the molecule NC(=O)[C@@H](NC[C@@H]1CCCO1)c1ccc(Br)cc1F.,NC(=O)[C@@H](NC[C@@H]1CCCO1)c1ccc(Br)cc1F,amide
228110,Remove a benzene_ring from the molecule O=C(Nc1ccc(S(=O)(=O)N[C@@H](c2ccccc2)C2CC2)cc1)C(F)(F)F.,O=C(Nc1ccc(S(=O)(=O)N[C@@H](c2ccccc2)C2CC2)cc1)C(F)(F)F,benzene_ring
93586,Modify the molecule C[C@@H](O)c1cccn1Cc1cc(Br)ccc1F by removing a halo.,C[C@@H](O)c1cccn1Cc1cc(Br)ccc1F,halo
24565,Please remove a benzene_ring from the molecule N#Cc1ccc(NC(=O)N2CCN(C(=O)CCC3CCCCC3)CC2)cc1.,N#Cc1ccc(NC(=O)N2CCN(C(=O)CCC3CCCCC3)CC2)cc1,benzene_ring
200450,Modify the molecule O=C(Cc1ccc([N+](=O)[O-])cc1)N=c1[nH]c2ccccc2[nH]1 by removing a nitro.,O=C(Cc1ccc([N+](=O)[O-])cc1)N=c1[nH]c2ccccc2[nH]1,nitro
86482,Remove a benzene_ring from the molecule COc1ccccc1C[C@H]1CCCN1C(=O)c1cnc([C@H]2CCCO2)s1.,COc1ccccc1C[C@H]1CCCN1C(=O)c1cnc([C@H]2CCCO2)s1,benzene_ring
22420,Please remove a benzene_ring from the molecule C[C@H]1CC[C@H](C[NH3+])CN1[C@@H](C)c1cc(F)cc(F)c1.,C[C@H]1CC[C@H](C[NH3+])CN1[C@@H](C)c1cc(F)cc(F)c1,benzene_ring
137334,Remove a halo from the molecule C[C@H]1C[C@H]1c1ccc(CN(C(=O)c2c[nH]c(=O)c(Cl)c2)C2CC2)o1.,C[C@H]1C[C@H]1c1ccc(CN(C(=O)c2c[nH]c(=O)c(Cl)c2)C2CC2)o1,halo
35182,Please remove a amide from the molecule COC[C@H](C)NC(=O)C(=O)Nc1cccc(-c2nc(C3CC3)n[nH]2)c1.,COC[C@H](C)NC(=O)C(=O)Nc1cccc(-c2nc(C3CC3)n[nH]2)c1,amide
198905,Modify the molecule C[C@@H]1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)C[C@H]1O by removing a halo.,C[C@@H]1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)C[C@H]1O,halo
130851,Remove a halo from the molecule Cc1ccc(Cn2nc(C)c(C(=O)N3CCN(CCOc4ccccc4)CC3)c2Cl)cc1.,Cc1ccc(Cn2nc(C)c(C(=O)N3CCN(CCOc4ccccc4)CC3)c2Cl)cc1,halo
90042,Modify the molecule COc1ccc2c(C)c(CCC(=O)N[C@@H]3C[C@@H]3C)c(=O)oc2c1 by removing a amide.,COc1ccc2c(C)c(CCC(=O)N[C@@H]3C[C@@H]3C)c(=O)oc2c1,amide
45541,Please remove a amide from the molecule O=C(COC(=O)c1ccc(S(=O)(=O)N2CCCC2)cc1)Nc1ccc(F)cc1Cl.,O=C(COC(=O)c1ccc(S(=O)(=O)N2CCCC2)cc1)Nc1ccc(F)cc1Cl,amide
82299,Please remove a amide from the molecule Cc1ccc(-n2nc(C)cc2NC(=O)C(=O)N(C)CC(=O)NC(C)C)cc1.,Cc1ccc(-n2nc(C)cc2NC(=O)C(=O)N(C)CC(=O)NC(C)C)cc1,amide
235201,Remove a amide from the molecule CC(C)(C)CC(=O)Nc1ccccc1Oc1ccccc1.,CC(C)(C)CC(=O)Nc1ccccc1Oc1ccccc1,amide
242827,Remove a amide from the molecule O=C([C@H]1CCC[NH+]1[C@H]1CCC[C@@H](C2CC2)C1)N1CCOCC1.,O=C([C@H]1CCC[NH+]1[C@H]1CCC[C@@H](C2CC2)C1)N1CCOCC1,amide
120558,Please remove a halo from the molecule CC(=O)Nc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1.,CC(=O)Nc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1,halo
181869,Please remove a halo from the molecule O=C(CS(=O)(=O)Cc1noc(-c2ccccc2Cl)n1)NCC1CCC1.,O=C(CS(=O)(=O)Cc1noc(-c2ccccc2Cl)n1)NCC1CCC1,halo
185864,Remove a amide from the molecule COC(=O)c1cccc(NC(=O)/C(=C/c2ccco2)c2ccccc2)c1.,COC(=O)c1cccc(NC(=O)/C(=C/c2ccco2)c2ccccc2)c1,amide
206801,Remove a amide from the molecule CCN(CC)C(=O)c1ccc([N+](=O)[O-])c(C)c1.,CCN(CC)C(=O)c1ccc([N+](=O)[O-])c(C)c1,amide
194608,Modify the molecule Cc1csc(CNC(=O)[C@@H]2CSCN2C(=O)OC(C)(C)C)n1 by removing a amide.,Cc1csc(CNC(=O)[C@@H]2CSCN2C(=O)OC(C)(C)C)n1,amide
92787,Modify the molecule C[NH2+][C@H](CCO)c1cccnc1Cl by removing a halo.,C[NH2+][C@H](CCO)c1cccnc1Cl,halo
149027,Remove a hydroxyl from the molecule C#CCC[C@@H](O)[C@]1([NH+](C)C)CCC[C@H](C)C1.,C#CCC[C@@H](O)[C@]1([NH+](C)C)CCC[C@H](C)C1,hydroxyl
197619,Remove a benzene_ring from the molecule CC1CCN(C(=O)[C@@H](C)Sc2nnnn2Cc2ccccc2)CC1.,CC1CCN(C(=O)[C@@H](C)Sc2nnnn2Cc2ccccc2)CC1,benzene_ring
31084,Remove a nitro from the molecule Cc1ccoc1C(=O)OCc1ccc([N+](=O)[O-])cc1.,Cc1ccoc1C(=O)OCc1ccc([N+](=O)[O-])cc1,nitro
168644,Remove a benzene_ring from the molecule OC1(C(F)(F)F)CC[NH+](Cc2ncc(-c3cccc(Cl)c3)o2)CC1.,OC1(C(F)(F)F)CC[NH+](Cc2ncc(-c3cccc(Cl)c3)o2)CC1,benzene_ring
222627,Please remove a halo from the molecule CN(Cc1ccc(Cl)nc1)C(=O)NCc1ccc(-n2cncn2)cc1.,CN(Cc1ccc(Cl)nc1)C(=O)NCc1ccc(-n2cncn2)cc1,halo
170677,Modify the molecule COc1ccccc1-n1c(SCc2c(C)noc2C)nc2ccsc2c1=O by removing a benzene_ring.,COc1ccccc1-n1c(SCc2c(C)noc2C)nc2ccsc2c1=O,benzene_ring
182393,Modify the molecule C[C@@H](Cc1ccsc1)N(C)C(=O)c1ccc(CNS(C)(=O)=O)o1 by removing a amine.,C[C@@H](Cc1ccsc1)N(C)C(=O)c1ccc(CNS(C)(=O)=O)o1,amine
168698,Modify the molecule Cc1cccc(N2C[C@H](c3nc4ccccc4n3C[C@@H](O)COc3ccc(Cl)cc3)CC2=O)c1 by removing a benzene_ring.,Cc1cccc(N2C[C@H](c3nc4ccccc4n3C[C@@H](O)COc3ccc(Cl)cc3)CC2=O)c1,benzene_ring
209142,Please remove a halo from the molecule CC[C@@H](C)NC(=O)N1CC[C@H](Oc2ccc(C(F)(F)F)cn2)C1.,CC[C@@H](C)NC(=O)N1CC[C@H](Oc2ccc(C(F)(F)F)cn2)C1,halo
3807,Remove a amide from the molecule Cn1ccnc1SCC(=O)N1CCC(C(=O)N2CCCCCC2)CC1.,Cn1ccnc1SCC(=O)N1CCC(C(=O)N2CCCCCC2)CC1,amide
106584,Please remove a halo from the molecule CC(=O)N(CCc1ccccc1)CC(=O)Nc1ccc(C(N)=O)cc1F.,CC(=O)N(CCc1ccccc1)CC(=O)Nc1ccc(C(N)=O)cc1F,halo
94524,Modify the molecule CN(C)C(=O)c1ccc(F)c(NC(=O)c2ccnc(Cl)c2)c1 by removing a benzene_ring.,CN(C)C(=O)c1ccc(F)c(NC(=O)c2ccnc(Cl)c2)c1,benzene_ring
101365,Remove a amide from the molecule Cc1c[nH]c(CN(C)C(=O)[C@@]23CNC[C@@H]2C[NH2+]C3)[nH+]1.,Cc1c[nH]c(CN(C)C(=O)[C@@]23CNC[C@@H]2C[NH2+]C3)[nH+]1,amide
32789,Remove a benzene_ring from the molecule COc1ccccc1[C@@H]1c2cccn2CCN1C(=O)CN(C(=O)c1ccco1)C(C)C.,COc1ccccc1[C@@H]1c2cccn2CCN1C(=O)CN(C(=O)c1ccco1)C(C)C,benzene_ring
18956,Remove a amine from the molecule CCCOc1ccc(-c2nc(N)ccc2[N+](=O)[O-])cc1.,CCCOc1ccc(-c2nc(N)ccc2[N+](=O)[O-])cc1,amine
176285,Remove a benzene_ring from the molecule COc1c(Br)cccc1CNC(=O)N(C)[C@H](C)C1CC1.,COc1c(Br)cccc1CNC(=O)N(C)[C@H](C)C1CC1,benzene_ring
201625,Modify the molecule CCc1nnc(NC(=O)c2ccccc2NC(=O)[C@H]2CC(=O)N(c3ccc(Cl)cc3)C2)s1 by removing a benzene_ring.,CCc1nnc(NC(=O)c2ccccc2NC(=O)[C@H]2CC(=O)N(c3ccc(Cl)cc3)C2)s1,benzene_ring
233705,Modify the molecule Cc1ccc(C(=O)NNC(=O)CCc2c[nH]c3c(C)cccc23)o1 by removing a amide.,Cc1ccc(C(=O)NNC(=O)CCc2c[nH]c3c(C)cccc23)o1,amide
179507,Remove a halo from the molecule CN(C)c1nc(N)nc(CN2CC[C@H](c3cccc(F)c3)C2)n1.,CN(C)c1nc(N)nc(CN2CC[C@H](c3cccc(F)c3)C2)n1,halo
19884,Modify the molecule Cc1cc(CNC(=O)CCC[NH+]2CCN(c3ccccc3)CC2)on1 by removing a amide.,Cc1cc(CNC(=O)CCC[NH+]2CCN(c3ccccc3)CC2)on1,amide
36647,Please remove a benzene_ring from the molecule CS(=O)(=O)c1ccc(Nc2ccccc2)c(N)c1.,CS(=O)(=O)c1ccc(Nc2ccccc2)c(N)c1,benzene_ring
24068,Modify the molecule CC[NH2+][C@@H](c1ccccc1OCC)[C@@H](C)c1ccccn1 by removing a benzene_ring.,CC[NH2+][C@@H](c1ccccc1OCC)[C@@H](C)c1ccccn1,benzene_ring
225306,Modify the molecule Cc1[nH]c2ccccc2c1CC(=O)OCC(=O)N(C(C)C)C(C)C by removing a amide.,Cc1[nH]c2ccccc2c1CC(=O)OCC(=O)N(C(C)C)C(C)C,amide
114451,Modify the molecule COc1ccc(Cc2nc3ccccc3n2CC(=O)N2CCCC[C@@H]2C)cc1OC by removing a benzene_ring.,COc1ccc(Cc2nc3ccccc3n2CC(=O)N2CCCC[C@@H]2C)cc1OC,benzene_ring
207567,Modify the molecule Clc1ccc(C[NH+]2CCCCC2)c(Cl)c1 by removing a halo.,Clc1ccc(C[NH+]2CCCCC2)c(Cl)c1,halo
70730,Remove a halo from the molecule CC(C)[C@H]([NH3+])c1noc(Cc2ccc(F)c(F)c2)n1.,CC(C)[C@H]([NH3+])c1noc(Cc2ccc(F)c(F)c2)n1,halo
85999,Please remove a amine from the molecule Nc1ccc2nc(-c3cccc(-c4nc5ccc(N)cc5s4)n3)sc2c1.,Nc1ccc2nc(-c3cccc(-c4nc5ccc(N)cc5s4)n3)sc2c1,amine
9874,Please remove a halo from the molecule COc1cccc(CN(C)Cc2ncnn2C)c1OC(F)F.,COc1cccc(CN(C)Cc2ncnn2C)c1OC(F)F,halo
138032,Modify the molecule Cc1cc(N)nn1Cc1ccc(F)cc1Cl by removing a benzene_ring.,Cc1cc(N)nn1Cc1ccc(F)cc1Cl,benzene_ring
199376,Modify the molecule Cc1nc(C)n(C[C@@H]2CCC[NH+]2Cc2cnn(-c3ccccc3)n2)n1 by removing a benzene_ring.,Cc1nc(C)n(C[C@@H]2CCC[NH+]2Cc2cnn(-c3ccccc3)n2)n1,benzene_ring
214620,Please remove a benzene_ring from the molecule Cc1ccc(-c2nc3ccccc3c3nnc(S[C@H](C)C(=O)NC[C@@H]4CCCO4)n23)cc1.,Cc1ccc(-c2nc3ccccc3c3nnc(S[C@H](C)C(=O)NC[C@@H]4CCCO4)n23)cc1,benzene_ring
94637,Modify the molecule CN(C)S(=O)(=O)c1cc(C(=O)NCc2csc(=O)[nH]2)co1 by removing a amide.,CN(C)S(=O)(=O)c1cc(C(=O)NCc2csc(=O)[nH]2)co1,amide
54449,Remove a benzene_ring from the molecule C[S@](=O)c1ccc(CNC(=O)CCc2c(F)cccc2F)cc1.,C[S@](=O)c1ccc(CNC(=O)CCc2c(F)cccc2F)cc1,benzene_ring
959,Modify the molecule c1ccc(Cn2c(SCc3ncon3)nnc2-c2cccs2)cc1 by removing a benzene_ring.,c1ccc(Cn2c(SCc3ncon3)nnc2-c2cccs2)cc1,benzene_ring
113513,Please remove a benzene_ring from the molecule CCc1c(C[NH2+]CC(C)C)cnn1-c1ccccc1Br.,CCc1c(C[NH2+]CC(C)C)cnn1-c1ccccc1Br,benzene_ring
135573,Remove a amide from the molecule COc1cccc(N2CCN(C(=O)c3cccc(OC)c3O)CC2)c1.,COc1cccc(N2CCN(C(=O)c3cccc(OC)c3O)CC2)c1,amide
73681,Modify the molecule CNc1ncnc(-c2cc(Br)ccc2F)c1[N+](=O)[O-] by removing a benzene_ring.,CNc1ncnc(-c2cc(Br)ccc2F)c1[N+](=O)[O-],benzene_ring
17113,Remove a amide from the molecule Cc1nsc(NC(=O)[C@@H]2C=C[C@@H]([NH3+])C2)c1C(=O)[O-].,Cc1nsc(NC(=O)[C@@H]2C=C[C@@H]([NH3+])C2)c1C(=O)[O-],amide
87312,Modify the molecule C[C@@H]1CCc2nc(C[NH+](C)CC(=O)Nc3ccccc3)sc2C1 by removing a benzene_ring.,C[C@@H]1CCc2nc(C[NH+](C)CC(=O)Nc3ccccc3)sc2C1,benzene_ring
111949,Modify the molecule C[NH+]1CCC[C@@H](C(=O)NCC(=O)Nc2cccc(F)c2)C1 by removing a amide.,C[NH+]1CCC[C@@H](C(=O)NCC(=O)Nc2cccc(F)c2)C1,amide
180668,Remove a amide from the molecule Cc1ccc(F)cc1NC(=O)[C@@H](C)O/N=C/C(=O)Nc1ccc(F)cc1.,Cc1ccc(F)cc1NC(=O)[C@@H](C)O/N=C/C(=O)Nc1ccc(F)cc1,amide
76161,Modify the molecule Cc1ccc(C(=O)C2CC[NH+](Cc3ccc(-n4cncn4)c(C)c3)CC2)cc1 by removing a benzene_ring.,Cc1ccc(C(=O)C2CC[NH+](Cc3ccc(-n4cncn4)c(C)c3)CC2)cc1,benzene_ring
131561,Please remove a benzene_ring from the molecule Cn1ccnc1SCC(=O)NCc1coc(-c2ccccc2)n1.,Cn1ccnc1SCC(=O)NCc1coc(-c2ccccc2)n1,benzene_ring
53723,Please remove a benzene_ring from the molecule CC[C@@H](C)C(=O)Nc1c(C)cc(C)cc1Cl.,CC[C@@H](C)C(=O)Nc1c(C)cc(C)cc1Cl,benzene_ring
172485,Modify the molecule C#CCN(CC(=O)[O-])[C@H](C)c1ccccc1[N+](=O)[O-] by removing a nitro.,C#CCN(CC(=O)[O-])[C@H](C)c1ccccc1[N+](=O)[O-],nitro
180418,Remove a amide from the molecule CC(C)[C@H](C(=O)Oc1cccc(-n2cccn2)c1)N1CCCC1=O.,CC(C)[C@H](C(=O)Oc1cccc(-n2cccn2)c1)N1CCCC1=O,amide
183295,Modify the molecule COc1ccc(Br)cc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccccc1 by removing a halo.,COc1ccc(Br)cc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccccc1,halo
53736,Remove a nitro from the molecule O=C(Nc1cccc2c1CCCC2)c1ccc([N+](=O)[O-])s1.,O=C(Nc1cccc2c1CCCC2)c1ccc([N+](=O)[O-])s1,nitro
236718,Modify the molecule COc1ccc(N2CCN(C(=O)CN3C(=O)[C@@H]4CC=CC[C@H]4C3=O)CC2)cc1 by removing a amide.,COc1ccc(N2CCN(C(=O)CN3C(=O)[C@@H]4CC=CC[C@H]4C3=O)CC2)cc1,amide
39753,Remove a amide from the molecule CSc1cc2c(cc1NC(=O)c1cccc(F)c1Cl)OCCO2.,CSc1cc2c(cc1NC(=O)c1cccc(F)c1Cl)OCCO2,amide
171727,Modify the molecule C[C@@H](CC(=O)N1CC[NH2+]CC1)CC(C)(C)C by removing a amide.,C[C@@H](CC(=O)N1CC[NH2+]CC1)CC(C)(C)C,amide
164249,Modify the molecule Cc1ccc(NC(=O)[C@H]2Oc3ccccc3[C@H]2NC(=O)C2=NN=C(c3cc(Cl)ccc3O)C2)cc1 by removing a hydroxyl.,Cc1ccc(NC(=O)[C@H]2Oc3ccccc3[C@H]2NC(=O)C2=NN=C(c3cc(Cl)ccc3O)C2)cc1,hydroxyl
174961,Modify the molecule CC(C)[C@H](NC(=O)c1ccccc1F)C(=O)N1CCOC[C@H]1C by removing a benzene_ring.,CC(C)[C@H](NC(=O)c1ccccc1F)C(=O)N1CCOC[C@H]1C,benzene_ring
109015,Modify the molecule CCC(=O)Nc1ccc(S(=O)(=O)N(C(=O)CC)c2ccccc2)cc1 by removing a amide.,CCC(=O)Nc1ccc(S(=O)(=O)N(C(=O)CC)c2ccccc2)cc1,amide
57102,Please remove a amide from the molecule C[C@H]1C[C@H]([NH3+])CN(CC(=O)N2CCC[C@H]3CCCC[C@@H]32)C1.,C[C@H]1C[C@H]([NH3+])CN(CC(=O)N2CCC[C@H]3CCCC[C@@H]32)C1,amide
100085,Modify the molecule O=C(NC[C@@H]1CCCO1)c1ccc2c(c1)[C@H]1C=CC[C@H]1[C@@H](c1ccc3ccccc3c1)N2 by removing a amine.,O=C(NC[C@@H]1CCCO1)c1ccc2c(c1)[C@H]1C=CC[C@H]1[C@@H](c1ccc3ccccc3c1)N2,amine
3858,Please remove a amide from the molecule C[C@H](CC1CCCC1)C(=O)Nc1ccc(C(=O)NC2CCOCC2)cc1.,C[C@H](CC1CCCC1)C(=O)Nc1ccc(C(=O)NC2CCOCC2)cc1,amide
164209,Remove a benzene_ring from the molecule CCC(C)(C)NC(=O)/C=C/c1ccc(S(=O)(=O)N2CCCCCC2)cc1.,CCC(C)(C)NC(=O)/C=C/c1ccc(S(=O)(=O)N2CCCCCC2)cc1,benzene_ring
226050,Modify the molecule Cn1c(=O)ccn(CC(=O)NC2(c3ccc(F)cc3F)CCCC2)c1=O by removing a halo.,Cn1c(=O)ccn(CC(=O)NC2(c3ccc(F)cc3F)CCCC2)c1=O,halo
45772,Please remove a benzene_ring from the molecule CCc1ncc(CN(C)C(=O)c2c[nH]nc2-c2ccc(OC)cc2)s1.,CCc1ncc(CN(C)C(=O)c2c[nH]nc2-c2ccc(OC)cc2)s1,benzene_ring
132003,Remove a halo from the molecule COc1ccc(Cl)cc1NC(=O)CC[C@@H]1CCC[NH+](C2CCOCC2)C1.,COc1ccc(Cl)cc1NC(=O)CC[C@@H]1CCC[NH+](C2CCOCC2)C1,halo
204733,Please remove a benzene_ring from the molecule COc1ccc(CC2(CO)CCN(c3ccc4ccccc4[nH+]3)CC2)cc1.,COc1ccc(CC2(CO)CCN(c3ccc4ccccc4[nH+]3)CC2)cc1,benzene_ring
26467,Please remove a benzene_ring from the molecule Cc1cc(-c2nnc(CN3CCC[C@H]3Cc3cccc(F)c3)o2)c(C)o1.,Cc1cc(-c2nnc(CN3CCC[C@H]3Cc3cccc(F)c3)o2)c(C)o1,benzene_ring
153486,Modify the molecule CCc1ccc(NC(=O)C(=O)N(C)Cc2cccs2)cc1[N+](=O)[O-] by removing a benzene_ring.,CCc1ccc(NC(=O)C(=O)N(C)Cc2cccs2)cc1[N+](=O)[O-],benzene_ring
124689,Modify the molecule CN1CCc2nc[nH]c2C12CC[NH+](Cc1cnn(-c3ccccc3F)c1)CC2 by removing a benzene_ring.,CN1CCc2nc[nH]c2C12CC[NH+](Cc1cnn(-c3ccccc3F)c1)CC2,benzene_ring
169868,Modify the molecule CC(C)c1nn(-c2ccccc2Cl)c(N)c1I by removing a amine.,CC(C)c1nn(-c2ccccc2Cl)c(N)c1I,amine
83390,Please remove a benzene_ring from the molecule CCc1ccc(C[NH+]2CCN(C(=O)Cc3ccccc3F)CC2)o1.,CCc1ccc(C[NH+]2CCN(C(=O)Cc3ccccc3F)CC2)o1,benzene_ring
84311,Remove a benzene_ring from the molecule CCOC(=O)c1c(NC(=O)c2ccc(SC)cc2)sc2c1CC[NH+](CC)C2.,CCOC(=O)c1c(NC(=O)c2ccc(SC)cc2)sc2c1CC[NH+](CC)C2,benzene_ring
186206,Modify the molecule CC(=O)c1ccc(NC(=O)[C@@H]2CC(=O)N=C(N3CC[NH+](Cc4ccc5c(c4)OCO5)CC3)N2)cc1 by removing a amide.,CC(=O)c1ccc(NC(=O)[C@@H]2CC(=O)N=C(N3CC[NH+](Cc4ccc5c(c4)OCO5)CC3)N2)cc1,amide
44978,Modify the molecule COc1cccc2c1OC[C@@H](C(=O)N1CCC[C@H](c3ccn[nH]3)C1)C2 by removing a amide.,COc1cccc2c1OC[C@@H](C(=O)N1CCC[C@H](c3ccn[nH]3)C1)C2,amide
187776,Remove a benzene_ring from the molecule O=C(NCc1ccc(-n2cccn2)cc1)N1CCC[C@H]1c1ccc2c(c1)OCCO2.,O=C(NCc1ccc(-n2cccn2)cc1)N1CCC[C@H]1c1ccc2c(c1)OCCO2,benzene_ring
178449,Remove a benzene_ring from the molecule CO[C@H]1C[NH2+][C@H](C(=O)NCCc2ccc(F)cc2C)C1.,CO[C@H]1C[NH2+][C@H](C(=O)NCCc2ccc(F)cc2C)C1,benzene_ring
243795,Please remove a amide from the molecule O=C(Nn1cnc2ccccc2c1=O)c1cccc(S(=O)(=O)N2CCCCC2)c1.,O=C(Nn1cnc2ccccc2c1=O)c1cccc(S(=O)(=O)N2CCCCC2)c1,amide
92926,Modify the molecule Cc1nc(-c2ccccc2Cl)nc2sc(C(=O)[O-])c(N)c12 by removing a benzene_ring.,Cc1nc(-c2ccccc2Cl)nc2sc(C(=O)[O-])c(N)c12,benzene_ring
4010,Please remove a amide from the molecule NC(=O)CONC(=O)[C@H]1CCCc2sccc21.,NC(=O)CONC(=O)[C@H]1CCCc2sccc21,amide
460,Modify the molecule Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1 by removing a halo.,Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1,halo
194062,Please remove a amide from the molecule CC[C@H](NC(=O)C1=Cc2cc(Cl)ccc2OC1)c1c(C)nn(C)c1C.,CC[C@H](NC(=O)C1=Cc2cc(Cl)ccc2OC1)c1c(C)nn(C)c1C,amide
167710,Remove a amine from the molecule COc1ccccc1NS(=O)(=O)c1ccc(Cc2cc(C)n[nH]c2=O)cc1.,COc1ccccc1NS(=O)(=O)c1ccc(Cc2cc(C)n[nH]c2=O)cc1,amine
149824,Modify the molecule Cn1ccc2cc(S(=O)(=O)N3CCC[C@H](C(=O)N4CCC5(CC4)OCCO5)C3)ccc21 by removing a amide.,Cn1ccc2cc(S(=O)(=O)N3CCC[C@H](C(=O)N4CCC5(CC4)OCCO5)C3)ccc21,amide
239006,Remove a amide from the molecule O=C(NCc1cccs1)c1ccc([C@H]2Nc3ccccc3S(=O)(=O)N2)cc1.,O=C(NCc1cccs1)c1ccc([C@H]2Nc3ccccc3S(=O)(=O)N2)cc1,amide
226478,Remove a amine from the molecule CNc1ccc(C[NH+]2C[C@H](C)[C@@H](C)C2)cn1.,CNc1ccc(C[NH+]2C[C@H](C)[C@@H](C)C2)cn1,amine
125154,Modify the molecule CC(C)N(CC(F)F)C(=O)C1C[C@H](C)O[C@H](C)C1 by removing a halo.,CC(C)N(CC(F)F)C(=O)C1C[C@H](C)O[C@H](C)C1,halo
128523,Remove a amide from the molecule COC[C@H](NC(=O)Cc1coc2cc(C)c(C)cc12)C(N)=O.,COC[C@H](NC(=O)Cc1coc2cc(C)c(C)cc12)C(N)=O,amide
149126,Please remove a halo from the molecule Cc1nn(C)c(Cl)c1CSc1nnnn1C(C)C.,Cc1nn(C)c(Cl)c1CSc1nnnn1C(C)C,halo
168731,Remove a benzene_ring from the molecule NC(=O)c1cccc(CNC(=O)[C@H]2C[C@H]2c2ccc(F)cc2)c1.,NC(=O)c1cccc(CNC(=O)[C@H]2C[C@H]2c2ccc(F)cc2)c1,benzene_ring
166885,Please remove a amide from the molecule NC(=O)c1cc(-c2cs/c(=N\C[C@@H]3CCCO3)n2/N=C/c2ccccn2)ccc1O.,NC(=O)c1cc(-c2cs/c(=N\C[C@@H]3CCCO3)n2/N=C/c2ccccn2)ccc1O,amide
218331,Please remove a amide from the molecule Cc1ccc(-n2nc(N3CCC[C@H](C(=O)Nc4ccc(F)cc4F)C3)ccc2=O)cc1Cl.,Cc1ccc(-n2nc(N3CCC[C@H](C(=O)Nc4ccc(F)cc4F)C3)ccc2=O)cc1Cl,amide
133352,Remove a halo from the molecule CSCCOC(=O)[C@@H](C)Oc1cccc(Cl)c1.,CSCCOC(=O)[C@@H](C)Oc1cccc(Cl)c1,halo
127165,Modify the molecule CN(CCCS(C)(=O)=O)C(=O)[C@H]1CCCC[NH+]1Cc1cccnc1 by removing a amide.,CN(CCCS(C)(=O)=O)C(=O)[C@H]1CCCC[NH+]1Cc1cccnc1,amide
136936,Please remove a benzene_ring from the molecule CSc1ccc([C@H](C)[NH2+][C@H](C[C@@H]2CCOC2)c2ccccc2)cc1.,CSc1ccc([C@H](C)[NH2+][C@H](C[C@@H]2CCOC2)c2ccccc2)cc1,benzene_ring
42293,Please remove a halo from the molecule C[C@H]1Sc2nnc(-c3ccncc3)n2N=C1c1ccc(F)c(F)c1.,C[C@H]1Sc2nnc(-c3ccncc3)n2N=C1c1ccc(F)c(F)c1,halo
188535,Remove a benzene_ring from the molecule CN(c1ccc(-c2nc(Cc3ccc(F)cc3)no2)c[nH+]1)C1CCOCC1.,CN(c1ccc(-c2nc(Cc3ccc(F)cc3)no2)c[nH+]1)C1CCOCC1,benzene_ring
112944,Please remove a amide from the molecule C[C@@H]1C[C@@H](N(C)C(=O)c2cc(CCc3ccccc3)ccc2O)CC[NH+]1C.,C[C@@H]1C[C@@H](N(C)C(=O)c2cc(CCc3ccccc3)ccc2O)CC[NH+]1C,amide
123033,Please remove a amide from the molecule O=C(CCn1ccc2ccccc21)Nc1ccc2c(c1)CCC(=O)N2.,O=C(CCn1ccc2ccccc21)Nc1ccc2c(c1)CCC(=O)N2,amide
168939,Please remove a benzene_ring from the molecule CCOC(=O)C1=C(C)Nc2ncnn2[C@@H]1c1cc(Cl)c(OC)c(OC)c1.,CCOC(=O)C1=C(C)Nc2ncnn2[C@@H]1c1cc(Cl)c(OC)c(OC)c1,benzene_ring
60736,Modify the molecule CCc1ccc(NC(=O)[C@H](C)Nc2ccc3c(c2)CCN3C(C)=O)cc1 by removing a amine.,CCc1ccc(NC(=O)[C@H](C)Nc2ccc3c(c2)CCN3C(C)=O)cc1,amine
59367,Remove a benzene_ring from the molecule COCc1ccc(C(=O)NCCC2CCN(c3cc[nH+]cc3)CC2)cc1.,COCc1ccc(C(=O)NCCC2CCN(c3cc[nH+]cc3)CC2)cc1,benzene_ring
57585,Please remove a hydroxyl from the molecule CC(C)=CC(=O)C[C@@](O)(c1ccccc1)C(F)(F)F.,CC(C)=CC(=O)C[C@@](O)(c1ccccc1)C(F)(F)F,hydroxyl
45916,Modify the molecule COC(=O)CNC(=O)CCc1c[nH]c2ccc(C)cc12 by removing a amide.,COC(=O)CNC(=O)CCc1c[nH]c2ccc(C)cc12,amide
42810,Remove a amide from the molecule O=C1NC(=O)[C@@H](CC(=O)N2CCOCC2)N1.,O=C1NC(=O)[C@@H](CC(=O)N2CCOCC2)N1,amide
89813,Modify the molecule COCCN(Cc1ccco1)C(=O)Nc1ccc(Cl)c([N+](=O)[O-])c1 by removing a nitro.,COCCN(Cc1ccco1)C(=O)Nc1ccc(Cl)c([N+](=O)[O-])c1,nitro
202209,Remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N2CCNC(=O)CC2)cc1[N+](=O)[O-].,Cc1ccc(S(=O)(=O)N2CCNC(=O)CC2)cc1[N+](=O)[O-],benzene_ring
56915,Modify the molecule CC(=O)c1cccc(NC(=O)c2cc(C)nc3c2c(C)nn3-c2ccc(F)cc2)c1 by removing a amide.,CC(=O)c1cccc(NC(=O)c2cc(C)nc3c2c(C)nn3-c2ccc(F)cc2)c1,amide
109356,Modify the molecule Cc1nc2cc(NC(=O)[C@H]3CCCN(c4ccc(-n5ccnc5)nn4)C3)ccc2s1 by removing a amide.,Cc1nc2cc(NC(=O)[C@H]3CCCN(c4ccc(-n5ccnc5)nn4)C3)ccc2s1,amide
139750,Modify the molecule Cc1ccc(Cl)cc1N1CCN([C@@H](c2ccccc2F)c2nnnn2Cc2ccco2)CC1 by removing a benzene_ring.,Cc1ccc(Cl)cc1N1CCN([C@@H](c2ccccc2F)c2nnnn2Cc2ccco2)CC1,benzene_ring
25598,Modify the molecule Cc1cccc(C(=O)Nc2ccc3c(c2)OCCCO3)c1C by removing a amide.,Cc1cccc(C(=O)Nc2ccc3c(c2)OCCCO3)c1C,amide
117474,Modify the molecule CCc1ccccc1NC(=O)CN(C)C(=O)[C@@H]1CC(=O)N(c2ccccc2CC)C1 by removing a amide.,CCc1ccccc1NC(=O)CN(C)C(=O)[C@@H]1CC(=O)N(c2ccccc2CC)C1,amide
2493,Please remove a amide from the molecule CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C.,CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C,amide
205310,Remove a amide from the molecule C[C@H]1OCC[C@H]1C(=O)Nc1ccc2nc(-c3cccs3)[nH]c2c1.,C[C@H]1OCC[C@H]1C(=O)Nc1ccc2nc(-c3cccs3)[nH]c2c1,amide
177148,Modify the molecule CC[C@@H](C)[C@](C)(O)[C@@H]1CCC[NH2+]C1 by removing a hydroxyl.,CC[C@@H](C)[C@](C)(O)[C@@H]1CCC[NH2+]C1,hydroxyl
117860,Please remove a benzene_ring from the molecule O=C([O-])CCc1nc(-c2ccccc2)c(-c2ccccc2)o1.,O=C([O-])CCc1nc(-c2ccccc2)c(-c2ccccc2)o1,benzene_ring
238912,Remove a halo from the molecule Cc1ccc(NC(=O)N(C)CCOc2ccccc2F)cc1-n1cnnn1.,Cc1ccc(NC(=O)N(C)CCOc2ccccc2F)cc1-n1cnnn1,halo
65251,Please remove a hydroxyl from the molecule C[C@@H](CCO)SCC(=O)c1cc(F)ccc1O.,C[C@@H](CCO)SCC(=O)c1cc(F)ccc1O,hydroxyl
129199,Please remove a benzene_ring from the molecule CC[NH2+][C@@H](CC[C@@H]1Cc2ccccc2S1)c1ccccc1.,CC[NH2+][C@@H](CC[C@@H]1Cc2ccccc2S1)c1ccccc1,benzene_ring
199246,Modify the molecule CNC(=O)[C@@H]1CN(C(=O)[C@H]2CC(=O)N(c3ccc4c(c3)OCCO4)C2)c2ccccc2O1 by removing a amide.,CNC(=O)[C@@H]1CN(C(=O)[C@H]2CC(=O)N(c3ccc4c(c3)OCCO4)C2)c2ccccc2O1,amide
219408,Remove a amide from the molecule COc1c(F)cc(NC(=O)C(=O)N2CC[C@H](OCCC(C)C)C2)cc1F.,COc1c(F)cc(NC(=O)C(=O)N2CC[C@H](OCCC(C)C)C2)cc1F,amide
237259,Please remove a amide from the molecule CC(C)c1cc(=O)[nH]c(-n2nc(-c3cccs3)cc2NC(=O)Cc2ccc(Cl)cc2)n1.,CC(C)c1cc(=O)[nH]c(-n2nc(-c3cccs3)cc2NC(=O)Cc2ccc(Cl)cc2)n1,amide
13468,Please remove a halo from the molecule O=C1OC(/C=C\c2ccccc2)=N/C1=C\c1cccc(Cl)c1.,O=C1OC(/C=C\c2ccccc2)=N/C1=C\c1cccc(Cl)c1,halo
132502,Modify the molecule CCC[C@@H]1CN(Cc2ccc(N3CCOCC3)c(F)c2)CC[NH2+]1 by removing a benzene_ring.,CCC[C@@H]1CN(Cc2ccc(N3CCOCC3)c(F)c2)CC[NH2+]1,benzene_ring
13492,Modify the molecule CCC(CC)CNc1nccn(CC(C)C)c1=O by removing a amine.,CCC(CC)CNc1nccn(CC(C)C)c1=O,amine
190762,Remove a hydroxyl from the molecule C[C@@H](Cc1ccc(O)cc1)NC(=O)Nc1cc(C#N)ccc1OC(F)F.,C[C@@H](Cc1ccc(O)cc1)NC(=O)Nc1cc(C#N)ccc1OC(F)F,hydroxyl
70993,Remove a hydroxyl from the molecule Cc1cc(C)cc(OC[C@H](O)C[NH+]2CCC[C@@H]2c2cc(C)no2)c1.,Cc1cc(C)cc(OC[C@H](O)C[NH+]2CCC[C@@H]2c2cc(C)no2)c1,hydroxyl
174284,Please remove a benzene_ring from the molecule COC(=O)[C@H]1CCC[C@H]1NC(=O)Nc1ccc(F)c(C)c1.,COC(=O)[C@H]1CCC[C@H]1NC(=O)Nc1ccc(F)c(C)c1,benzene_ring
208985,Modify the molecule CCOc1c(F)cccc1C(=O)NCCC(=O)N1CCCCCC1 by removing a benzene_ring.,CCOc1c(F)cccc1C(=O)NCCC(=O)N1CCCCCC1,benzene_ring
29307,Remove a amide from the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)c3ccco3)CC2)cc1C.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)c3ccco3)CC2)cc1C,amide
41691,Please remove a hydroxyl from the molecule Cc1cccc(NC(=O)c2sc3c(c2C)[C@H](c2cccc(O)c2)CC(O)=N3)c1.,Cc1cccc(NC(=O)c2sc3c(c2C)[C@H](c2cccc(O)c2)CC(O)=N3)c1,hydroxyl
247442,Remove a amide from the molecule Cc1c(NS(C)(=O)=O)cccc1C(=O)N1CCCCCC1.,Cc1c(NS(C)(=O)=O)cccc1C(=O)N1CCCCCC1,amide
115986,Modify the molecule CS(=O)(=O)[C@@H]1CCC[C@@H]([NH2+]Cc2cccc(Oc3ccccc3)c2)C1 by removing a benzene_ring.,CS(=O)(=O)[C@@H]1CCC[C@@H]([NH2+]Cc2cccc(Oc3ccccc3)c2)C1,benzene_ring
88983,Please remove a halo from the molecule Cc1cc(C(=O)N[C@H](C)c2cccnc2)sc1Br.,Cc1cc(C(=O)N[C@H](C)c2cccnc2)sc1Br,halo
245901,Please remove a benzene_ring from the molecule O=C(Cn1ccnc1)NCc1ccc(-c2ccc(Cl)cc2)o1.,O=C(Cn1ccnc1)NCc1ccc(-c2ccc(Cl)cc2)o1,benzene_ring
193701,Modify the molecule CC[C@H]1COCCN1Cc1cc(Cl)c(OC)c(OC)c1 by removing a benzene_ring.,CC[C@H]1COCCN1Cc1cc(Cl)c(OC)c(OC)c1,benzene_ring
95045,Remove a hydroxyl from the molecule Cc1ccc2ccc([C@@H](Nc3cccc[nH+]3)c3ccc(O)cc3)c([O-])c2n1.,Cc1ccc2ccc([C@@H](Nc3cccc[nH+]3)c3ccc(O)cc3)c([O-])c2n1,hydroxyl
36559,Please remove a amide from the molecule O=C(Nc1ccc2c(c1)N(C(=O)C1CCCC1)CC2)c1ccc2ccccc2n1.,O=C(Nc1ccc2c(c1)N(C(=O)C1CCCC1)CC2)c1ccc2ccccc2n1,amide
119364,Modify the molecule O=C(NCc1ccc2c(c1)OCO2)c1cn(C[C@H]2CCCO2)cc2c(=O)n(-c3ccccc3)nc1-2 by removing a amide.,O=C(NCc1ccc2c(c1)OCO2)c1cn(C[C@H]2CCCO2)cc2c(=O)n(-c3ccccc3)nc1-2,amide
141530,Modify the molecule CNC(=O)NCC(=O)Nc1cccc(OCc2cccc(F)c2)c1 by removing a benzene_ring.,CNC(=O)NCC(=O)Nc1cccc(OCc2cccc(F)c2)c1,benzene_ring
103209,Remove a halo from the molecule Cc1cc(Br)ccc1NC(=O)CCCn1c2ccccc2c(=O)c2ccccc21.,Cc1cc(Br)ccc1NC(=O)CCCn1c2ccccc2c(=O)c2ccccc21,halo
126856,Please remove a amide from the molecule CCCN[C@@](C)(C[NH+]1C[C@@H](C)[C@@H](C)C1)C(N)=O.,CCCN[C@@](C)(C[NH+]1C[C@@H](C)[C@@H](C)C1)C(N)=O,amide
103784,Modify the molecule C[C@@H](C(=O)N[C@H](C)c1ccc(S(N)(=O)=O)cc1)[NH+]1CCC(C)(C)C1 by removing a benzene_ring.,C[C@@H](C(=O)N[C@H](C)c1ccc(S(N)(=O)=O)cc1)[NH+]1CCC(C)(C)C1,benzene_ring
14069,Please remove a amide from the molecule CC[C@@H]1CCCC[C@@H]1N(C)C(=O)Nc1ccc(C(=O)NC)cc1Cl.,CC[C@@H]1CCCC[C@@H]1N(C)C(=O)Nc1ccc(C(=O)NC)cc1Cl,amide
5633,Remove a halo from the molecule C[C@@H](Oc1ccc([N+](=O)[O-])cc1C=O)C(=O)Nc1ccc(Cl)cc1.,C[C@@H](Oc1ccc([N+](=O)[O-])cc1C=O)C(=O)Nc1ccc(Cl)cc1,halo
89895,Remove a amine from the molecule Cc1ccc(S(=O)(=O)NCC[NH+]2CCN(c3ccccc3F)CC2)s1.,Cc1ccc(S(=O)(=O)NCC[NH+]2CCN(c3ccccc3F)CC2)s1,amine
168394,Remove a amide from the molecule C[C@H](Sc1ccc(F)cc1)C(=O)Nc1ccc(OC(F)(F)F)cc1.,C[C@H](Sc1ccc(F)cc1)C(=O)Nc1ccc(OC(F)(F)F)cc1,amide
32186,Modify the molecule CCN1CCO[C@H](c2nc(-c3cccc(C[NH3+])c3)cs2)C1 by removing a benzene_ring.,CCN1CCO[C@H](c2nc(-c3cccc(C[NH3+])c3)cs2)C1,benzene_ring
148367,Remove a amide from the molecule CCN(CC)S(=O)(=O)c1ccc(NC(=O)Cc2coc3cc(C)c(C)cc23)cc1.,CCN(CC)S(=O)(=O)c1ccc(NC(=O)Cc2coc3cc(C)c(C)cc23)cc1,amide
111379,Modify the molecule COc1ccc(C(=O)[C@@H](C#N)c2nnc3n2CCCCC3)cc1Br by removing a benzene_ring.,COc1ccc(C(=O)[C@@H](C#N)c2nnc3n2CCCCC3)cc1Br,benzene_ring
111720,Modify the molecule CCOc1ccc(CCC(=O)NC2(C(N)=O)CCCC2)cc1 by removing a benzene_ring.,CCOc1ccc(CCC(=O)NC2(C(N)=O)CCCC2)cc1,benzene_ring
181121,Remove a amide from the molecule CCC[C@@]1(C2CCN(C(=O)c3noc4c3CCCC4)CC2)NC(=O)N(CCc2ccccn2)C1=O.,CCC[C@@]1(C2CCN(C(=O)c3noc4c3CCCC4)CC2)NC(=O)N(CCc2ccccn2)C1=O,amide
122342,Please remove a amide from the molecule CCn1c(-c2ccc3c(c2)OCCO3)cnc1S[C@H](C)C(=O)NC(=O)NC(C)(C)C.,CCn1c(-c2ccc3c(c2)OCCO3)cnc1S[C@H](C)C(=O)NC(=O)NC(C)(C)C,amide
144432,Modify the molecule C[C@@H](NC(=O)N[C@@H](c1ccccc1)C(C)(C)C)c1nncn1C by removing a benzene_ring.,C[C@@H](NC(=O)N[C@@H](c1ccccc1)C(C)(C)C)c1nncn1C,benzene_ring
203720,Please remove a nitrile from the molecule COc1ccc([C@@H]2C(C#N)=C(N)OC3=C2[C@@H](C)N=N3)cc1.,COc1ccc([C@@H]2C(C#N)=C(N)OC3=C2[C@@H](C)N=N3)cc1,nitrile
175576,Please remove a benzene_ring from the molecule C[NH2+][C@H](Cc1cc(C)cc(C)c1)[C@@H]1C[NH+]2CCN1CC2.,C[NH2+][C@H](Cc1cc(C)cc(C)c1)[C@@H]1C[NH+]2CCN1CC2,benzene_ring
238005,Modify the molecule COC(=O)C[C@H](NS(C)(=O)=O)C(=O)OC by removing a amine.,COC(=O)C[C@H](NS(C)(=O)=O)C(=O)OC,amine
15954,Modify the molecule CCS(=O)(=O)NCc1ccc(C(=O)N2C[C@H](C)S[C@@H](C)C2)cc1 by removing a amide.,CCS(=O)(=O)NCc1ccc(C(=O)N2C[C@H](C)S[C@@H](C)C2)cc1,amide
10481,Please remove a amide from the molecule CC[S@@](=O)CCN1C(=O)NC(C)(C)C1=O.,CC[S@@](=O)CCN1C(=O)NC(C)(C)C1=O,amide
135868,Modify the molecule O=C(Nc1ccc(CC(=O)N2CCOc3ccccc32)cc1)C1CC1 by removing a amide.,O=C(Nc1ccc(CC(=O)N2CCOc3ccccc32)cc1)C1CC1,amide
230102,Remove a benzene_ring from the molecule CC(C)CCn1cc(C(=O)NCc2ccc([S@@](C)=O)cc2)nn1.,CC(C)CCn1cc(C(=O)NCc2ccc([S@@](C)=O)cc2)nn1,benzene_ring
83776,Remove a amine from the molecule O=c1c([N+](=O)[O-])c(NCc2ccsc2)nc2ccccn12.,O=c1c([N+](=O)[O-])c(NCc2ccsc2)nc2ccccn12,amine
75406,Please remove a amide from the molecule CCOC(=O)[C@H]1CCCC2=c3cccc(C(N)=O)c3=[NH+][C@H]21.,CCOC(=O)[C@H]1CCCC2=c3cccc(C(N)=O)c3=[NH+][C@H]21,amide
166866,Remove a amide from the molecule Cc1cc(NC(=O)[C@H]2COc3ccccc3O2)c2ncccc2c1.,Cc1cc(NC(=O)[C@H]2COc3ccccc3O2)c2ncccc2c1,amide
105401,Modify the molecule CC(C)NC(=O)C[NH2+][C@H]1CSCCC1(C)C by removing a amide.,CC(C)NC(=O)C[NH2+][C@H]1CSCCC1(C)C,amide
44847,Modify the molecule C[C@@H](NC(=O)c1csc(-c2cccs2)n1)[C@H]1CCCO1 by removing a amide.,C[C@@H](NC(=O)c1csc(-c2cccs2)n1)[C@H]1CCCO1,amide
104150,Please remove a benzene_ring from the molecule CCCCOc1ccc(CN2CCO[C@H](c3nc(C)cs3)C2)cc1.,CCCCOc1ccc(CN2CCO[C@H](c3nc(C)cs3)C2)cc1,benzene_ring
42934,Remove a halo from the molecule COc1ccc(NC(=O)Cn2c(=O)n(Cc3ccccc3F)c(=O)c3sccc32)cc1OC.,COc1ccc(NC(=O)Cn2c(=O)n(Cc3ccccc3F)c(=O)c3sccc32)cc1OC,halo
77862,Please remove a benzene_ring from the molecule COc1ccccc1N1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1.,COc1ccccc1N1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1,benzene_ring
234024,Please remove a benzene_ring from the molecule COc1ccc(CN(C)C(=O)c2cn(Cc3cccnc3)nn2)cc1C.,COc1ccc(CN(C)C(=O)c2cn(Cc3cccnc3)nn2)cc1C,benzene_ring
138233,Modify the molecule CS(=O)(=O)N1CCC2(CC1)Oc1ccc(Br)cc1[C@H]1CC(c3ccncc3)=NN12 by removing a halo.,CS(=O)(=O)N1CCC2(CC1)Oc1ccc(Br)cc1[C@H]1CC(c3ccncc3)=NN12,halo
108828,Modify the molecule COCCOc1ncccc1C(=O)N1CC[S@@](=O)C(C)(C)C1 by removing a amide.,COCCOc1ncccc1C(=O)N1CC[S@@](=O)C(C)(C)C1,amide
6922,Please remove a amide from the molecule CO[C@H](CNC(=O)c1ccoc1C)c1ccc(F)cc1.,CO[C@H](CNC(=O)c1ccoc1C)c1ccc(F)cc1,amide
238584,Please remove a benzene_ring from the molecule Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCOc2ccccc21)C(C)C.,Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCOc2ccccc21)C(C)C,benzene_ring
37612,Remove a amide from the molecule CCOC(=O)C1CCN(C(=O)CC(F)(F)F)CC1.,CCOC(=O)C1CCN(C(=O)CC(F)(F)F)CC1,amide
142065,Please remove a benzene_ring from the molecule Cc1noc(C)c1CSc1ccccc1C(=O)N1CCO[C@H](c2ccc(F)cc2)C1.,Cc1noc(C)c1CSc1ccccc1C(=O)N1CCO[C@H](c2ccc(F)cc2)C1,benzene_ring
2288,Modify the molecule C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1 by removing a amide.,C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1,amide
218066,Please remove a amide from the molecule O=C(N[C@@H]1CCCCC[C@H]1C(=O)[O-])[C@@H]1CCOC1.,O=C(N[C@@H]1CCCCC[C@H]1C(=O)[O-])[C@@H]1CCOC1,amide
75060,Please remove a amide from the molecule C[C@@H](Cc1ccco1)NC(=O)c1ccc2nsnc2c1.,C[C@@H](Cc1ccco1)NC(=O)c1ccc2nsnc2c1,amide
209700,Modify the molecule CCOC(=O)C1=C(C)N(C)C(=S)N[C@H]1c1cccc(NC(=O)c2ccc(Br)cc2)c1 by removing a benzene_ring.,CCOC(=O)C1=C(C)N(C)C(=S)N[C@H]1c1cccc(NC(=O)c2ccc(Br)cc2)c1,benzene_ring
20624,Modify the molecule CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CN(C(=O)c1cnn3c(-c4ccccc4)ccnc13)CC2 by removing a amide.,CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CN(C(=O)c1cnn3c(-c4ccccc4)ccnc13)CC2,amide
70242,Please remove a hydroxyl from the molecule O[C@@H](COCc1cccs1)Cn1nnc(-c2ccccc2)n1.,O[C@@H](COCc1cccs1)Cn1nnc(-c2ccccc2)n1,hydroxyl
175845,Remove a amide from the molecule C[C@H](C(=O)Nc1ccc2c(c1)OCO2)N(Cc1cccnc1)C(=O)Cn1nnc2ccccc21.,C[C@H](C(=O)Nc1ccc2c(c1)OCO2)N(Cc1cccnc1)C(=O)Cn1nnc2ccccc21,amide
144596,Please remove a halo from the molecule Cc1ccc2c(Cl)cc(Cl)c(OCC(=O)N3CCN(c4ncccn4)CC3)c2n1.,Cc1ccc2c(Cl)cc(Cl)c(OCC(=O)N3CCN(c4ncccn4)CC3)c2n1,halo
34875,Please remove a amide from the molecule Cc1cccc(NC(=O)CN2CC[NH+](C[C@@H]3CCCO3)CC2)c1C.,Cc1cccc(NC(=O)CN2CC[NH+](C[C@@H]3CCCO3)CC2)c1C,amide
174375,Please remove a benzene_ring from the molecule COc1ccc(N2C(=O)/C(=C/c3c[nH]c4ccccc34)SC2=S)cc1.,COc1ccc(N2C(=O)/C(=C/c3c[nH]c4ccccc34)SC2=S)cc1,benzene_ring
220349,Remove a benzene_ring from the molecule CC[C@@](C)([NH2+]Cc1ccc(C(N)=O)cc1F)C(=O)[O-].,CC[C@@](C)([NH2+]Cc1ccc(C(N)=O)cc1F)C(=O)[O-],benzene_ring
108506,Remove a benzene_ring from the molecule Cc1cnc(CNC(=O)NNc2ccccc2Cl)s1.,Cc1cnc(CNC(=O)NNc2ccccc2Cl)s1,benzene_ring
195113,Modify the molecule CCN[C@]1(C(=O)OC)CC[C@@H](N2CCOC[C@@H]2C)C1 by removing a amine.,CCN[C@]1(C(=O)OC)CC[C@@H](N2CCOC[C@@H]2C)C1,amine
70066,Please remove a benzene_ring from the molecule CC[NH+]1CCN(c2ccc(F)cc2[N+](=O)[O-])CC1.,CC[NH+]1CCN(c2ccc(F)cc2[N+](=O)[O-])CC1,benzene_ring
59564,Please remove a amide from the molecule C[C@H](c1ccc(S(N)(=O)=O)cc1)N(C)C(=O)CSCc1cccc(Cl)c1.,C[C@H](c1ccc(S(N)(=O)=O)cc1)N(C)C(=O)CSCc1cccc(Cl)c1,amide
189964,Remove a amine from the molecule C/C(=C/C(=O)OCc1nc(N)c2ccccc2n1)C1CC1.,C/C(=C/C(=O)OCc1nc(N)c2ccccc2n1)C1CC1,amine
232002,Please remove a benzene_ring from the molecule O=C(CCn1cc[nH+]c1)Nc1cccc(C(=O)N2CCOC[C@@H]2C2CC2)c1.,O=C(CCn1cc[nH+]c1)Nc1cccc(C(=O)N2CCOC[C@@H]2C2CC2)c1,benzene_ring
10833,Modify the molecule CSc1cccc(NCc2cccc(C)n2)c1 by removing a benzene_ring.,CSc1cccc(NCc2cccc(C)n2)c1,benzene_ring
216640,Please remove a hydroxyl from the molecule CC(C)C[NH+](C1CCCC1)[C@H]1C[C@H](C(C)(C)C)CC[C@@H]1O.,CC(C)C[NH+](C1CCCC1)[C@H]1C[C@H](C(C)(C)C)CC[C@@H]1O,hydroxyl
32675,Please remove a benzene_ring from the molecule COc1cc(=O)n(-c2ccccc2C)nc1C(=O)Nc1ccc(Cl)cc1Cl.,COc1cc(=O)n(-c2ccccc2C)nc1C(=O)Nc1ccc(Cl)cc1Cl,benzene_ring
186070,Remove a amine from the molecule CCOCC1(CNc2nc(C)nc3c2c(C)nn3C)CCC1.,CCOCC1(CNc2nc(C)nc3c2c(C)nn3C)CCC1,amine
182297,Modify the molecule COc1ccccc1CSCc1nnc(-c2ccccc2F)o1 by removing a benzene_ring.,COc1ccccc1CSCc1nnc(-c2ccccc2F)o1,benzene_ring
167780,Modify the molecule COCc1cccc(CNC(=O)c2cc(C(N)=O)cn2C)c1 by removing a benzene_ring.,COCc1cccc(CNC(=O)c2cc(C(N)=O)cn2C)c1,benzene_ring
63254,Please remove a benzene_ring from the molecule Cc1ccc(Oc2nccn3c(=O)n(CC(=O)N4CCN(c5ccccc5F)CC4)nc23)cc1.,Cc1ccc(Oc2nccn3c(=O)n(CC(=O)N4CCN(c5ccccc5F)CC4)nc23)cc1,benzene_ring
121266,Remove a halo from the molecule Cc1cc(C(=O)c2ccc(Br)o2)sc1C.,Cc1cc(C(=O)c2ccc(Br)o2)sc1C,halo
164376,Please remove a benzene_ring from the molecule Clc1ccc(NCc2ccc[nH]2)cc1Br.,Clc1ccc(NCc2ccc[nH]2)cc1Br,benzene_ring
76198,Remove a benzene_ring from the molecule N#Cc1ccc(CCC(=O)Oc2ccc(Cl)cc2)cc1.,N#Cc1ccc(CCC(=O)Oc2ccc(Cl)cc2)cc1,benzene_ring
148420,Remove a benzene_ring from the molecule COc1ccc(OC)c(N(CC(=O)N2CCOCC2)S(C)(=O)=O)c1.,COc1ccc(OC)c(N(CC(=O)N2CCOCC2)S(C)(=O)=O)c1,benzene_ring
139767,Please remove a benzene_ring from the molecule NC(=O)CCn1nc(-c2ccc(F)cc2)c2ccccc2c1=O.,NC(=O)CCn1nc(-c2ccc(F)cc2)c2ccccc2c1=O,benzene_ring
204894,Please remove a amide from the molecule CCn1c(C(=O)N[C@H]2CCC[C@H](S(C)(=O)=O)C2)cc2ccccc21.,CCn1c(C(=O)N[C@H]2CCC[C@H](S(C)(=O)=O)C2)cc2ccccc21,amide
225319,Please remove a benzene_ring from the molecule O=C(Cc1cn2ccccc2[nH+]1)Nc1cccc(F)c1.,O=C(Cc1cn2ccccc2[nH+]1)Nc1cccc(F)c1,benzene_ring
119625,Remove a benzene_ring from the molecule O=C(C[C@H]1CCS(=O)(=O)C1)Oc1cccc(Oc2ccccc2)c1.,O=C(C[C@H]1CCS(=O)(=O)C1)Oc1cccc(Oc2ccccc2)c1,benzene_ring
87453,Modify the molecule CCc1nn(C)cc1NC(=O)C(=O)NCC1(c2ccccc2)CC1 by removing a amide.,CCc1nn(C)cc1NC(=O)C(=O)NCC1(c2ccccc2)CC1,amide
183959,Remove a amine from the molecule CSc1nccnc1CNC[C@@H]1CCCC[NH2+]1.,CSc1nccnc1CNC[C@@H]1CCCC[NH2+]1,amine
114463,Remove a halo from the molecule COc1ccc(NC(=O)NCCc2cccc(Cl)c2)cc1NC(C)=O.,COc1ccc(NC(=O)NCCc2cccc(Cl)c2)cc1NC(C)=O,halo
79386,Remove a benzene_ring from the molecule O=C(OCc1cccc(F)c1)c1ccc(N2CCNC2=O)cc1.,O=C(OCc1cccc(F)c1)c1ccc(N2CCNC2=O)cc1,benzene_ring
242558,Please remove a halo from the molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)[N-]c1ccc(Cl)cc1.,COc1ccc([N+](=O)[O-])cc1S(=O)(=O)[N-]c1ccc(Cl)cc1,halo
162515,Remove a amide from the molecule Cc1cc(NC(=O)CSc2ccc(S(=O)(=O)N3CCCC3)cn2)no1.,Cc1cc(NC(=O)CSc2ccc(S(=O)(=O)N3CCCC3)cn2)no1,amide
135481,Remove a benzene_ring from the molecule CC(C)C(=O)NC[C@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1.,CC(C)C(=O)NC[C@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1,benzene_ring
227144,Remove a benzene_ring from the molecule COc1cc(OC)cc(C(=O)Nn2cc(C(=O)NCc3ccccn3)c3ccccc3c2=O)c1.,COc1cc(OC)cc(C(=O)Nn2cc(C(=O)NCc3ccccn3)c3ccccc3c2=O)c1,benzene_ring
153260,Modify the molecule Cc1ccccc1O[C@H](C)CNC(=O)CN1C(=O)c2ccccc2C1=O by removing a benzene_ring.,Cc1ccccc1O[C@H](C)CNC(=O)CN1C(=O)c2ccccc2C1=O,benzene_ring
15766,Remove a amide from the molecule CC(=O)N1Cc2cc(C)ccc2OC2(CCN(C(=O)c3cc[nH]n3)CC2)C1.,CC(=O)N1Cc2cc(C)ccc2OC2(CCN(C(=O)c3cc[nH]n3)CC2)C1,amide
193460,Remove a halo from the molecule S=C1SCCN1CN1CCc2ccc(Cl)cc2C1.,S=C1SCCN1CN1CCc2ccc(Cl)cc2C1,halo
155725,Please remove a benzene_ring from the molecule C[C@@H](NC(=O)C(C)(C)NC(=O)Nc1ccccc1)c1ccc(Cl)s1.,C[C@@H](NC(=O)C(C)(C)NC(=O)Nc1ccccc1)c1ccc(Cl)s1,benzene_ring
83527,Remove a halo from the molecule NC(=O)[C@H]1CCN(C(=O)[C@H]2C[C@@H]2c2ccccc2Cl)C1.,NC(=O)[C@H]1CCN(C(=O)[C@H]2C[C@@H]2c2ccccc2Cl)C1,halo
236372,Modify the molecule CC[C@@H](Nc1ccc2nnc(-c3ccccc3F)n2n1)c1noc(C)n1 by removing a amine.,CC[C@@H](Nc1ccc2nnc(-c3ccccc3F)n2n1)c1noc(C)n1,amine
218086,Modify the molecule Cc1cccn2cc(C[S@](=O)[C@H](C)C(=O)NCc3ccccc3)nc12 by removing a benzene_ring.,Cc1cccn2cc(C[S@](=O)[C@H](C)C(=O)NCc3ccccc3)nc12,benzene_ring
15200,Please remove a nitrile from the molecule N#Cc1ccc(CCC(=O)N[C@@H](Cc2ccccc2)C2CC2)cc1.,N#Cc1ccc(CCC(=O)N[C@@H](Cc2ccccc2)C2CC2)cc1,nitrile
233755,Modify the molecule CCCCNC(=O)NNC(=O)Cc1cccs1 by removing a amide.,CCCCNC(=O)NNC(=O)Cc1cccs1,amide
11340,Modify the molecule COc1ccc([C@@H](C)N[C@H]2CCN(CC(F)(F)F)C2=O)c(OC)c1 by removing a halo.,COc1ccc([C@@H](C)N[C@H]2CCN(CC(F)(F)F)C2=O)c(OC)c1,halo
185275,Remove a benzene_ring from the molecule Cc1nc(-c2cccc(C[NH2+][C@H](C)c3cnn(C(C)C)c3)c2)n[nH]1.,Cc1nc(-c2cccc(C[NH2+][C@H](C)c3cnn(C(C)C)c3)c2)n[nH]1,benzene_ring
89840,Modify the molecule [NH3+][C@@H](c1ccn(CCC(F)(F)F)c1)C1CC1 by removing a halo.,[NH3+][C@@H](c1ccn(CCC(F)(F)F)c1)C1CC1,halo
118923,Modify the molecule CNc1cc[nH+]c(Cn2nccc2C)c1 by removing a amine.,CNc1cc[nH+]c(Cn2nccc2C)c1,amine
192259,Modify the molecule CC(C)(C)c1ccc(OCC(=O)N/N=C/c2ccc(N3CCOCC3)cc2)cc1 by removing a benzene_ring.,CC(C)(C)c1ccc(OCC(=O)N/N=C/c2ccc(N3CCOCC3)cc2)cc1,benzene_ring
196590,Remove a benzene_ring from the molecule Fc1ccc([C@H]2OCC[C@H]2CCl)cc1F.,Fc1ccc([C@H]2OCC[C@H]2CCl)cc1F,benzene_ring
111272,Modify the molecule COc1ccc(/C=C(\C)c2ccncc2)cc1 by removing a benzene_ring.,COc1ccc(/C=C(\C)c2ccncc2)cc1,benzene_ring
92090,Remove a amide from the molecule COc1ccc([C@H]2[C@@H](C(=O)NCc3ccc(F)cc3)c3ccccc3C(=O)N2C)cc1.,COc1ccc([C@H]2[C@@H](C(=O)NCc3ccc(F)cc3)c3ccccc3C(=O)N2C)cc1,amide
122887,Remove a amine from the molecule COc1ccc([C@@H]2SCCN2C(=S)Nc2ccc(Cl)cc2)cc1.,COc1ccc([C@@H]2SCCN2C(=S)Nc2ccc(Cl)cc2)cc1,amine
52051,Please remove a halo from the molecule NS(=O)(=O)CC1CC[NH+](Cc2ncc(-c3ccccc3Cl)o2)CC1.,NS(=O)(=O)CC1CC[NH+](Cc2ncc(-c3ccccc3Cl)o2)CC1,halo
97489,Modify the molecule CCNS(=O)(=O)[C@@H]1CC[NH+](CC(=O)Nc2ccccc2C(C)(C)C)C1 by removing a benzene_ring.,CCNS(=O)(=O)[C@@H]1CC[NH+](CC(=O)Nc2ccccc2C(C)(C)C)C1,benzene_ring
111963,Please remove a amide from the molecule O=C1[C@H]2[C@H]3C=C[C@H](CC3)[C@H]2C(=O)N1/N=C/c1cn(Cc2ccccc2Cl)c2ccccc12.,O=C1[C@H]2[C@H]3C=C[C@H](CC3)[C@H]2C(=O)N1/N=C/c1cn(Cc2ccccc2Cl)c2ccccc12,amide
96974,Modify the molecule CCOC(=O)Cn1c(=O)n(CCc2ccccc2)c(=O)c2c3c(sc21)COC(C)(C)C3 by removing a benzene_ring.,CCOC(=O)Cn1c(=O)n(CCc2ccccc2)c(=O)c2c3c(sc21)COC(C)(C)C3,benzene_ring
99146,Remove a halo from the molecule Cn1c(CNc2ccc(C(N)=O)c(F)c2)nnc1-c1ccccc1.,Cn1c(CNc2ccc(C(N)=O)c(F)c2)nnc1-c1ccccc1,halo
212323,Modify the molecule Cc1ccc(NC(=O)[C@@H](C)N2CCO[C@H](c3ccccc3)C2)c(F)c1 by removing a halo.,Cc1ccc(NC(=O)[C@@H](C)N2CCO[C@H](c3ccccc3)C2)c(F)c1,halo
231545,Please remove a benzene_ring from the molecule Cc1ccc(C)c(NC(=O)N2C[C@@H](C)C[C@@H](C)C2)c1.,Cc1ccc(C)c(NC(=O)N2C[C@@H](C)C[C@@H](C)C2)c1,benzene_ring
66859,Modify the molecule C[C@H](C[NH+]1CCCCC1)NC(=O)N1CCC(c2ccc(O)cc2)CC1 by removing a hydroxyl.,C[C@H](C[NH+]1CCCCC1)NC(=O)N1CCC(c2ccc(O)cc2)CC1,hydroxyl
187292,Please remove a amide from the molecule C[C@H]1c2cc3c(cc2C2(CCCC2)CN1C(=O)c1cccc(C#N)c1)OCCO3.,C[C@H]1c2cc3c(cc2C2(CCCC2)CN1C(=O)c1cccc(C#N)c1)OCCO3,amide
53305,Modify the molecule C[C@H]1OCC[C@@H]1C(=O)N1CCC[NH+](CC(=O)N(C)C)CC1 by removing a amide.,C[C@H]1OCC[C@@H]1C(=O)N1CCC[NH+](CC(=O)N(C)C)CC1,amide
19537,Please remove a amide from the molecule Cc1ccc(C(=O)NNC(=O)Cc2ccc(-c3ccccc3)cc2)o1.,Cc1ccc(C(=O)NNC(=O)Cc2ccc(-c3ccccc3)cc2)o1,amide
6154,Remove a benzene_ring from the molecule C[C@H](CC(=O)NN1C(=O)N[C@](C)(c2ccccc2)C1=O)c1ccccc1.,C[C@H](CC(=O)NN1C(=O)N[C@](C)(c2ccccc2)C1=O)c1ccccc1,benzene_ring
151442,Remove a amine from the molecule Cc1ccc(CNc2cccc(OCCCC#N)c2)o1.,Cc1ccc(CNc2cccc(OCCCC#N)c2)o1,amine
150763,Modify the molecule Cn1cc(C(=O)Nc2cc(Cl)ccc2[N-]S(=O)(=O)c2ccccc2F)cn1 by removing a benzene_ring.,Cn1cc(C(=O)Nc2cc(Cl)ccc2[N-]S(=O)(=O)c2ccccc2F)cn1,benzene_ring
201939,Remove a amide from the molecule CC(=O)N[C@@H]1CCN(c2nc(C)nc3c2c(C)nn3C)C1.,CC(=O)N[C@@H]1CCN(c2nc(C)nc3c2c(C)nn3C)C1,amide
62437,Please remove a benzene_ring from the molecule Cc1cccc(C)c1NC(=O)C[NH+](C)CC(=O)N1CCC[C@H]2CCCC[C@@H]21.,Cc1cccc(C)c1NC(=O)C[NH+](C)CC(=O)N1CCC[C@H]2CCCC[C@@H]21,benzene_ring
49395,Modify the molecule CN(C)[C@@H](C[NH2+]CC(=O)N1CCc2ccccc21)c1ccccc1 by removing a benzene_ring.,CN(C)[C@@H](C[NH2+]CC(=O)N1CCc2ccccc21)c1ccccc1,benzene_ring
210665,Remove a halo from the molecule C[C@H]1CN(C(C)(C)CNC(=O)CSCC(F)(F)F)C[C@@H](C)O1.,C[C@H]1CN(C(C)(C)CNC(=O)CSCC(F)(F)F)C[C@@H](C)O1,halo
247757,Please remove a halo from the molecule C[C@H](NC(=O)[C@H](C)Oc1ccccc1C(F)(F)F)C(=O)N(C)C.,C[C@H](NC(=O)[C@H](C)Oc1ccccc1C(F)(F)F)C(=O)N(C)C,halo
97656,Please remove a benzene_ring from the molecule CCOC(=O)[C@@H]1CCCN(C(=O)N[C@@H](C)c2ccccc2)C1.,CCOC(=O)[C@@H]1CCCN(C(=O)N[C@@H](C)c2ccccc2)C1,benzene_ring
217601,Please remove a amide from the molecule CC(C)OCc1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc(Br)s3)CC2)cc1.,CC(C)OCc1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc(Br)s3)CC2)cc1,amide
201961,Please remove a hydroxyl from the molecule O=C([O-])c1ccc(/N=C\c2ccccc2O)cc1.,O=C([O-])c1ccc(/N=C\c2ccccc2O)cc1,hydroxyl
153293,Please remove a nitrile from the molecule COC[C@@](C)(C#N)NC(=O)c1ccc(Br)cc1Br.,COC[C@@](C)(C#N)NC(=O)c1ccc(Br)cc1Br,nitrile
179824,Modify the molecule CCn1ccnc1CNC(=O)c1cn(Cc2ccccc2F)nn1 by removing a benzene_ring.,CCn1ccnc1CNC(=O)c1cn(Cc2ccccc2F)nn1,benzene_ring
150335,Modify the molecule Cc1ccc(-c2csc3ncn(CC(=O)Nc4ccc(F)cc4F)c(=O)c23)cc1 by removing a halo.,Cc1ccc(-c2csc3ncn(CC(=O)Nc4ccc(F)cc4F)c(=O)c23)cc1,halo
154548,Remove a amide from the molecule CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(CCO)S(C)(=O)=O)c(C3CC3)cc12.,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(CCO)S(C)(=O)=O)c(C3CC3)cc12,amide
64377,Remove a amine from the molecule N#Cc1ccc([C@H]2Nc3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1.,N#Cc1ccc([C@H]2Nc3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1,amine
127673,Modify the molecule COC(=O)C1=C[C@@H](S(=O)(=O)NC[C@H]2CCCO2)C=N1 by removing a amine.,COC(=O)C1=C[C@@H](S(=O)(=O)NC[C@H]2CCCO2)C=N1,amine
165405,Remove a amide from the molecule COCCCNC(=O)C(=O)c1c[nH]c2ccccc12.,COCCCNC(=O)C(=O)c1c[nH]c2ccccc12,amide
98988,Modify the molecule BrCC1(C[C@@H]2C[C@H]3CC[C@@H]2C3)CCCC1 by removing a halo.,BrCC1(C[C@@H]2C[C@H]3CC[C@@H]2C3)CCCC1,halo
234627,Please remove a amide from the molecule COc1ccccc1N1CC[C@@H]([NH2+][C@@H](C)C[C@H]2CCCO2)C1=O.,COc1ccccc1N1CC[C@@H]([NH2+][C@@H](C)C[C@H]2CCCO2)C1=O,amide
211636,Please remove a amide from the molecule COc1ccc(CCCNC(=O)[C@@H]2CN(C)CCO2)cc1OC.,COc1ccc(CCCNC(=O)[C@@H]2CN(C)CCO2)cc1OC,amide
34888,Modify the molecule O=C(Cc1cc([O-])nc(SCc2ccc(F)cc2)n1)N1CCN(c2cccc[nH+]2)CC1 by removing a benzene_ring.,O=C(Cc1cc([O-])nc(SCc2ccc(F)cc2)n1)N1CCN(c2cccc[nH+]2)CC1,benzene_ring
184353,Modify the molecule Cc1ccccc1C(=O)Nc1cc(NC(=O)c2ccccc2C)cc(C(=O)[O-])c1 by removing a amide.,Cc1ccccc1C(=O)Nc1cc(NC(=O)c2ccccc2C)cc(C(=O)[O-])c1,amide
165736,Remove a hydroxyl from the molecule OC[C@@]1([NH2+]C2CC2)CCC[C@H]1CCOC1CCCC1.,OC[C@@]1([NH2+]C2CC2)CCC[C@H]1CCOC1CCCC1,hydroxyl
19602,Please remove a benzene_ring from the molecule COC(=O)c1ccc(NCc2cccc([N+](=O)[O-])c2)cc1.,COC(=O)c1ccc(NCc2cccc([N+](=O)[O-])c2)cc1,benzene_ring
243958,Remove a amide from the molecule O=C(NC[C@H]1COc2ccccc2C1)[C@H]1COc2ccccc2O1.,O=C(NC[C@H]1COc2ccccc2C1)[C@H]1COc2ccccc2O1,amide
115081,Please remove a amine from the molecule O=[N+]([O-])c1cnc(NCCCn2cc[nH+]c2)c(Br)c1.,O=[N+]([O-])c1cnc(NCCCn2cc[nH+]c2)c(Br)c1,amine
10327,Remove a amide from the molecule Cc1cc(NC(=O)C[S@](=O)[C@H](C)c2ccc(Cl)c(Cl)c2)no1.,Cc1cc(NC(=O)C[S@](=O)[C@H](C)c2ccc(Cl)c(Cl)c2)no1,amide
173716,Please remove a amide from the molecule CN(CC(=O)N(CCC(F)(F)F)C1CCC1)c1ncnc2[nH]cnc12.,CN(CC(=O)N(CCC(F)(F)F)C1CCC1)c1ncnc2[nH]cnc12,amide
141388,Remove a amine from the molecule CC(C)NC(=O)C[NH+](C)Cc1nc2ccc(N)cc2o1.,CC(C)NC(=O)C[NH+](C)Cc1nc2ccc(N)cc2o1,amine
104059,Please remove a amide from the molecule Cc1nc2ccc(NC(=O)C(=O)NC3CC[NH+](CC4CCCCC4)CC3)cc2o1.,Cc1nc2ccc(NC(=O)C(=O)NC3CC[NH+](CC4CCCCC4)CC3)cc2o1,amide
48009,Remove a amide from the molecule COC(=O)N1CCC(CNC(=O)[C@H]2CC(=O)N(c3ccc(C)c(C)c3)C2)CC1.,COC(=O)N1CCC(CNC(=O)[C@H]2CC(=O)N(c3ccc(C)c(C)c3)C2)CC1,amide
92079,Please remove a amide from the molecule CC(C)n1cc(C(=O)Nc2ccc3cc[nH]c3c2)c2ccccc2c1=O.,CC(C)n1cc(C(=O)Nc2ccc3cc[nH]c3c2)c2ccccc2c1=O,amide
208881,Modify the molecule C[C@@H]1CC(C(=O)N2CCC[C@@H]2C(=O)N2CCN(C)CC2)C[C@@H](C)O1 by removing a amide.,C[C@@H]1CC(C(=O)N2CCC[C@@H]2C(=O)N2CCN(C)CC2)C[C@@H](C)O1,amide
35796,Modify the molecule COc1cccnc1NCc1cnc(-c2ccccn2)s1 by removing a amine.,COc1cccnc1NCc1cnc(-c2ccccn2)s1,amine
10915,Modify the molecule N#C[C@@H]1CCCC[C@H]1OC(=O)CCc1cc(Cl)cs1 by removing a nitrile.,N#C[C@@H]1CCCC[C@H]1OC(=O)CCc1cc(Cl)cs1,nitrile
77724,Remove a amide from the molecule O=C(Cc1cccc2ccccc12)N[C@H](c1ccccc1)c1ccncc1.,O=C(Cc1cccc2ccccc12)N[C@H](c1ccccc1)c1ccncc1,amide
498,Remove a benzene_ring from the molecule COC(=O)[C@H]1CCC[C@H]1NC(=O)Nc1ccc(C)cc1C.,COC(=O)[C@H]1CCC[C@H]1NC(=O)Nc1ccc(C)cc1C,benzene_ring
60056,Please remove a halo from the molecule O=C(COC(=O)c1cccs1)Nc1cc(S(=O)(=O)N2CCCC2)ccc1Cl.,O=C(COC(=O)c1cccs1)Nc1cc(S(=O)(=O)N2CCCC2)ccc1Cl,halo
48484,Modify the molecule CCCOc1ccc([C@@H]([NH2+]C)c2c(F)cccc2F)cc1 by removing a benzene_ring.,CCCOc1ccc([C@@H]([NH2+]C)c2c(F)cccc2F)cc1,benzene_ring
221387,Modify the molecule O=C(CSc1nc(-c2ccccc2)c[nH]1)N1CCN(c2ccccc2F)CC1 by removing a benzene_ring.,O=C(CSc1nc(-c2ccccc2)c[nH]1)N1CCN(c2ccccc2F)CC1,benzene_ring
5474,Modify the molecule O=C(NCc1ccccc1F)c1ccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)cc1 by removing a amide.,O=C(NCc1ccccc1F)c1ccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)cc1,amide
25846,Modify the molecule C[C@@H]1CN(C(=O)CSc2nnc(-c3ccccc3)n2N)C[C@@H](C)O1 by removing a amide.,C[C@@H]1CN(C(=O)CSc2nnc(-c3ccccc3)n2N)C[C@@H](C)O1,amide
109447,Please remove a amide from the molecule Cc1cc(NC(=O)CSc2nc3c(cnn3-c3cccc(Cl)c3)c(=O)[nH]2)no1.,Cc1cc(NC(=O)CSc2nc3c(cnn3-c3cccc(Cl)c3)c(=O)[nH]2)no1,amide
100931,Please remove a amide from the molecule C[C@@H]1CCCC[C@H]1NC(=O)Cc1coc2cc3c(cc12)CCC3.,C[C@@H]1CCCC[C@H]1NC(=O)Cc1coc2cc3c(cc12)CCC3,amide
122144,Remove a benzene_ring from the molecule CCc1noc(CN(C)C(=O)Nc2ccc(N3CCO[C@@H](C)C3)cc2)n1.,CCc1noc(CN(C)C(=O)Nc2ccc(N3CCO[C@@H](C)C3)cc2)n1,benzene_ring
91803,Modify the molecule Cc1cccc(C)c1OC[C@H](O)Cn1c([C@H]2CC(=O)N(c3ccccc3F)C2)nc2ccccc21 by removing a hydroxyl.,Cc1cccc(C)c1OC[C@H](O)Cn1c([C@H]2CC(=O)N(c3ccccc3F)C2)nc2ccccc21,hydroxyl
210960,Please remove a nitrile from the molecule N#Cc1ccc(C[NH+]2CC[C@@H](OCCCc3ccccc3)C2)cc1.,N#Cc1ccc(C[NH+]2CC[C@@H](OCCCc3ccccc3)C2)cc1,nitrile
30335,Remove a nitrile from the molecule CC(C)[C@H](C)SCC(=O)NC1(C#N)CCCCCC1.,CC(C)[C@H](C)SCC(=O)NC1(C#N)CCCCCC1,nitrile
195881,Modify the molecule COc1ccc(CC(=O)NC[C@H](c2cccs2)[NH+]2CCCCCC2)cc1 by removing a amide.,COc1ccc(CC(=O)NC[C@H](c2cccs2)[NH+]2CCCCCC2)cc1,amide
50591,Remove a benzene_ring from the molecule COc1ccccc1[C@H]([NH2+]Cc1cnn(C)c1C)C1CCCC1.,COc1ccccc1[C@H]([NH2+]Cc1cnn(C)c1C)C1CCCC1,benzene_ring
22650,Remove a hydroxyl from the molecule C[C@@H](CCCO)NC(=O)N1CCN(c2ncnc3sccc23)CC1.,C[C@@H](CCCO)NC(=O)N1CCN(c2ncnc3sccc23)CC1,hydroxyl
87977,Modify the molecule Cc1cc(CSc2ncccc2C(=O)Nc2ccc3oc(C)nc3c2)no1 by removing a amide.,Cc1cc(CSc2ncccc2C(=O)Nc2ccc3oc(C)nc3c2)no1,amide
75699,Please remove a halo from the molecule O=C(COc1ccc(Oc2ccccc2)cc1)Nc1cc(N2CCCC2=O)ccc1Cl.,O=C(COc1ccc(Oc2ccccc2)cc1)Nc1cc(N2CCCC2=O)ccc1Cl,halo
17122,Modify the molecule COc1cccc2c1C(=O)O[C@H]2S(=O)(=O)c1ccccc1 by removing a benzene_ring.,COc1cccc2c1C(=O)O[C@H]2S(=O)(=O)c1ccccc1,benzene_ring
176172,Modify the molecule COc1ccc(C2(C(=O)N3CCC[C@@H](c4ccn[nH]4)C3)CCCC2)cc1 by removing a amide.,COc1ccc(C2(C(=O)N3CCC[C@@H](c4ccn[nH]4)C3)CCCC2)cc1,amide
16075,Remove a halo from the molecule C[NH2+][C@H]1c2cc(F)c(F)cc2[S@](=O)[C@@H](C)[C@H]1C.,C[NH2+][C@H]1c2cc(F)c(F)cc2[S@](=O)[C@@H](C)[C@H]1C,halo
539,Modify the molecule COc1ccccc1CNC(=O)c1cc2sccc2n1Cc1cccc(F)c1 by removing a halo.,COc1ccccc1CNC(=O)c1cc2sccc2n1Cc1cccc(F)c1,halo
165374,Modify the molecule COc1ccc(Br)c(C(=O)N2CCC3(CC2)OCCN3S(=O)(=O)c2ccccc2)c1 by removing a amide.,COc1ccc(Br)c(C(=O)N2CCC3(CC2)OCCN3S(=O)(=O)c2ccccc2)c1,amide
48039,Please remove a amine from the molecule Nc1ccc(=O)n(CCCN2CCN3C(=O)NC[C@@H]3C2)c1.,Nc1ccc(=O)n(CCCN2CCN3C(=O)NC[C@@H]3C2)c1,amine
3375,Please remove a benzene_ring from the molecule COc1cc(NC(=O)c2cccc(-c3ccc(N4CCCC4)nn3)c2)cc(OC)c1.,COc1cc(NC(=O)c2cccc(-c3ccc(N4CCCC4)nn3)c2)cc(OC)c1,benzene_ring
227309,Modify the molecule C[C@@H](OC(=O)c1cn(C)c2ccccc12)C(=O)Nc1ccc(S(N)(=O)=O)cc1 by removing a amide.,C[C@@H](OC(=O)c1cn(C)c2ccccc12)C(=O)Nc1ccc(S(N)(=O)=O)cc1,amide
10844,Remove a benzene_ring from the molecule C[NH2+][C@H](CCO)c1ccccc1.,C[NH2+][C@H](CCO)c1ccccc1,benzene_ring
116944,Modify the molecule Nc1ccc(S[C@@H](C(=O)[O-])C2CC2)cc1F by removing a amine.,Nc1ccc(S[C@@H](C(=O)[O-])C2CC2)cc1F,amine
187003,Modify the molecule CC[C@H](C)C(=O)NCC(=O)Nc1ccc(OC)c2ncccc12 by removing a amide.,CC[C@H](C)C(=O)NCC(=O)Nc1ccc(OC)c2ncccc12,amide
195491,Modify the molecule CC[C@](C)([NH2+]CC(=O)Nc1c(C)n[nH]c1C)C(=O)[O-] by removing a amide.,CC[C@](C)([NH2+]CC(=O)Nc1c(C)n[nH]c1C)C(=O)[O-],amide
44420,Modify the molecule O=C(NCCCNC(=O)c1ccnc2ncccc12)c1cccc(F)c1 by removing a amide.,O=C(NCCCNC(=O)c1ccnc2ncccc12)c1cccc(F)c1,amide
156349,Remove a benzene_ring from the molecule C[C@H](NC(=O)c1cnc(Oc2ccccc2)cn1)[C@@H]1CCOC1.,C[C@H](NC(=O)c1cnc(Oc2ccccc2)cn1)[C@@H]1CCOC1,benzene_ring
206280,Please remove a benzene_ring from the molecule CCc1cc(=O)n(CC(=O)Nc2ccc(OC)cc2OC)c(-c2cccc(F)c2)n1.,CCc1cc(=O)n(CC(=O)Nc2ccc(OC)cc2OC)c(-c2cccc(F)c2)n1,benzene_ring
176923,Remove a benzene_ring from the molecule CNC(=O)c1ccc(CNC(=O)N[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1.,CNC(=O)c1ccc(CNC(=O)N[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1,benzene_ring
7835,Remove a nitrile from the molecule C[C@@H]1CC[C@](C#N)(C2(O)CCOCC2)C1.,C[C@@H]1CC[C@](C#N)(C2(O)CCOCC2)C1,nitrile
148039,Remove a amide from the molecule CCCn1c(C[NH+]2CCC(NC(=O)c3ccoc3C)CC2)nc2ccccc21.,CCCn1c(C[NH+]2CCC(NC(=O)c3ccoc3C)CC2)nc2ccccc21,amide
200849,Modify the molecule CC(=O)c1c(C)[nH]c(C(=O)N[C@@]2(C)CCS(=O)(=O)C2)c1C by removing a amide.,CC(=O)c1c(C)[nH]c(C(=O)N[C@@]2(C)CCS(=O)(=O)C2)c1C,amide
80831,Modify the molecule COc1ccc(N2CCN([C@@H]3CC(=O)N(c4ccc(C(F)(F)F)cc4)C3=O)CC2)cc1 by removing a benzene_ring.,COc1ccc(N2CCN([C@@H]3CC(=O)N(c4ccc(C(F)(F)F)cc4)C3=O)CC2)cc1,benzene_ring
100316,Please remove a benzene_ring from the molecule CC[C@@H](C)NC(=O)NCc1ccc(C[NH+](C)C)cc1.,CC[C@@H](C)NC(=O)NCc1ccc(C[NH+](C)C)cc1,benzene_ring
158075,Please remove a hydroxyl from the molecule Cc1ccccc1[C@H]([NH3+])CO.,Cc1ccccc1[C@H]([NH3+])CO,hydroxyl
9214,Remove a amide from the molecule CC(C)CN1CCO[C@@H](CNC(=O)CN2CC[S@@](=O)C(C)(C)C2)C1.,CC(C)CN1CCO[C@@H](CNC(=O)CN2CC[S@@](=O)C(C)(C)C2)C1,amide
190180,Remove a amide from the molecule O=C(NC1CCCCC1)[C@H]1CC(c2c(F)cccc2Cl)=NO1.,O=C(NC1CCCCC1)[C@H]1CC(c2c(F)cccc2Cl)=NO1,amide
215702,Modify the molecule CC(C)[C@@H](NC(=O)c1ccccc1F)C(=O)N[C@@H]1CCCC[C@@H]1C by removing a halo.,CC(C)[C@@H](NC(=O)c1ccccc1F)C(=O)N[C@@H]1CCCC[C@@H]1C,halo
249128,Please remove a amide from the molecule O=C(NCCNC(=O)[C@@H]1CC=CCC1)[C@@H]1CC=CCC1.,O=C(NCCNC(=O)[C@@H]1CC=CCC1)[C@@H]1CC=CCC1,amide
111050,Remove a amide from the molecule CC(C)CN1CCN(C(=O)Cc2c[nH]c(=O)n(C)c2=O)[C@H](C)C1=O.,CC(C)CN1CCN(C(=O)Cc2c[nH]c(=O)n(C)c2=O)[C@H](C)C1=O,amide
171678,Modify the molecule N#Cc1ccc(COC(=O)CCc2nc(-c3ncccn3)no2)cc1 by removing a benzene_ring.,N#Cc1ccc(COC(=O)CCc2nc(-c3ncccn3)no2)cc1,benzene_ring
62363,Remove a halo from the molecule Cc1[nH]nc(C(N)=O)c1NC(=O)[C@H](C)c1ccc(Br)s1.,Cc1[nH]nc(C(N)=O)c1NC(=O)[C@H](C)c1ccc(Br)s1,halo
155275,Modify the molecule CNC(=O)CN(C)C(=O)NCCOCC(=O)[O-] by removing a amide.,CNC(=O)CN(C)C(=O)NCCOCC(=O)[O-],amide
101634,Modify the molecule Cc1ccc(S(=O)(=O)N/N=C/c2cccs2)cc1 by removing a benzene_ring.,Cc1ccc(S(=O)(=O)N/N=C/c2cccs2)cc1,benzene_ring
5987,Remove a benzene_ring from the molecule Cc1ccccc1Cn1cc(C(=O)N2CCC([C@H](O)CCc3ccccc3)CC2)nn1.,Cc1ccccc1Cn1cc(C(=O)N2CCC([C@H](O)CCc3ccccc3)CC2)nn1,benzene_ring
179374,Please remove a halo from the molecule C[C@H](NC(=O)c1ccccc1Cl)[C@H]1COc2ccccc2O1.,C[C@H](NC(=O)c1ccccc1Cl)[C@H]1COc2ccccc2O1,halo
88185,Modify the molecule COCCn1ccc2ccc(NC(=O)c3cccc(-n4cnnn4)c3)cc21 by removing a amide.,COCCn1ccc2ccc(NC(=O)c3cccc(-n4cnnn4)c3)cc21,amide
223764,Please remove a amide from the molecule CN1CCO[C@@H](C(=O)NCc2ccc(Cn3ccccc3=O)cc2)C1.,CN1CCO[C@@H](C(=O)NCc2ccc(Cn3ccccc3=O)cc2)C1,amide
246624,Modify the molecule O=C(NCc1cccnc1)C1CC[NH+](C2CC[NH+](CC3CCCC3)CC2)CC1 by removing a amide.,O=C(NCc1cccnc1)C1CC[NH+](C2CC[NH+](CC3CCCC3)CC2)CC1,amide
220927,Please remove a amide from the molecule O=C(Nc1ccc(Cl)cc1F)[C@@H]1CCCN1C(=O)c1cc(Cl)ccc1Cl.,O=C(Nc1ccc(Cl)cc1F)[C@@H]1CCCN1C(=O)c1cc(Cl)ccc1Cl,amide
45825,Remove a amide from the molecule Cc1ccc([C@H](CNC(=O)[C@@H]2CSCN2C(=O)CC(C)(C)C)[NH+](C)C)cc1.,Cc1ccc([C@H](CNC(=O)[C@@H]2CSCN2C(=O)CC(C)(C)C)[NH+](C)C)cc1,amide
78748,Remove a benzene_ring from the molecule Cc1nc(C[NH2+]Cc2ccc(N3CCC[C@H](C(N)=O)C3)cc2)cs1.,Cc1nc(C[NH2+]Cc2ccc(N3CCC[C@H](C(N)=O)C3)cc2)cs1,benzene_ring
183600,Modify the molecule C[C@H](Oc1cccc(/C=C2/SC(=S)N(c3ccc(Cl)c(Cl)c3)C2=O)c1)C(=O)[O-] by removing a benzene_ring.,C[C@H](Oc1cccc(/C=C2/SC(=S)N(c3ccc(Cl)c(Cl)c3)C2=O)c1)C(=O)[O-],benzene_ring
185877,Please remove a halo from the molecule COC(=O)c1ccc(NC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)c(F)c1.,COC(=O)c1ccc(NC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)c(F)c1,halo
144020,Remove a halo from the molecule O=C([O-])c1c(-c2ccc(Cl)cc2)noc1CO[C@@H]1CCCCO1.,O=C([O-])c1c(-c2ccc(Cl)cc2)noc1CO[C@@H]1CCCCO1,halo
33001,Please remove a halo from the molecule CC1=NN(C(=O)COc2ccc(C(C)(C)c3ccccc3)cc2)[C@@](O)(C(F)(F)F)C1.,CC1=NN(C(=O)COc2ccc(C(C)(C)c3ccccc3)cc2)[C@@](O)(C(F)(F)F)C1,halo
148846,Remove a benzene_ring from the molecule CCc1nc(CS(=O)(=O)Cc2ccc(F)c(Br)c2)cs1.,CCc1nc(CS(=O)(=O)Cc2ccc(F)c(Br)c2)cs1,benzene_ring
156129,Remove a hydroxyl from the molecule CCn1ncc(C[NH+]2CCC3(CC2)c2ccccc2[C@@H]([NH+](C)C)[C@@H]3O)c1C.,CCn1ncc(C[NH+]2CCC3(CC2)c2ccccc2[C@@H]([NH+](C)C)[C@@H]3O)c1C,hydroxyl
164718,Modify the molecule COC(=O)CN[C@H]1CC[C@H]([NH3+])C1 by removing a amine.,COC(=O)CN[C@H]1CC[C@H]([NH3+])C1,amine
120380,Remove a amine from the molecule C[C@H](OC(=O)c1nccnc1N)c1nc(C(C)(C)C)no1.,C[C@H](OC(=O)c1nccnc1N)c1nc(C(C)(C)C)no1,amine
6098,Modify the molecule COc1ccc2cc(C(=O)N(C)c3ccc(OC)nc3)[nH]c2c1 by removing a amide.,COc1ccc2cc(C(=O)N(C)c3ccc(OC)nc3)[nH]c2c1,amide
64711,Modify the molecule N#Cc1ccc(N(C(=O)c2cc(=O)c3ccccc3o2)C2CC2)cc1 by removing a benzene_ring.,N#Cc1ccc(N(C(=O)c2cc(=O)c3ccccc3o2)C2CC2)cc1,benzene_ring
188397,Remove a benzene_ring from the molecule O=C(NC[C@@H](O)c1ccccc1Cl)c1ccc(OC(F)F)cc1.,O=C(NC[C@@H](O)c1ccccc1Cl)c1ccc(OC(F)F)cc1,benzene_ring
20060,Remove a nitrile from the molecule N#C[C@]1(C2(O)CC[NH2+]CC2)CCc2ccccc2C1.,N#C[C@]1(C2(O)CC[NH2+]CC2)CCc2ccccc2C1,nitrile
238699,Modify the molecule CCOC(=O)c1ccc(NC(=S)NC(=O)C2CC2)cc1 by removing a amide.,CCOC(=O)c1ccc(NC(=S)NC(=O)C2CC2)cc1,amide
181679,Remove a amine from the molecule O=C(c1ccccc1NS(=O)(=O)/C=C/c1ccccc1)N1CCCCC1.,O=C(c1ccccc1NS(=O)(=O)/C=C/c1ccccc1)N1CCCCC1,amine
34522,Please remove a amide from the molecule CC(C)(C)Oc1cc(C(=O)N2CCC(CO)CC2)ccn1.,CC(C)(C)Oc1cc(C(=O)N2CCC(CO)CC2)ccn1,amide
16662,Modify the molecule CN(CC(F)F)C(=O)CCc1ccc(F)cc1F by removing a amide.,CN(CC(F)F)C(=O)CCc1ccc(F)cc1F,amide
72047,Remove a halo from the molecule COc1ccc(-c2nn3c(SCC(=O)c4ccc(Cl)cc4)nnc3nc2[O-])cc1.,COc1ccc(-c2nn3c(SCC(=O)c4ccc(Cl)cc4)nnc3nc2[O-])cc1,halo
123669,Remove a amine from the molecule CCN[C@@]1(C(=O)OC)CC[C@@H](OC(C)(C)C)C1.,CCN[C@@]1(C(=O)OC)CC[C@@H](OC(C)(C)C)C1,amine
245999,Please remove a benzene_ring from the molecule C[C@@H]([C@H](C)C[NH2+]C(C)(C)C)N(C)Cc1ccccc1.,C[C@@H]([C@H](C)C[NH2+]C(C)(C)C)N(C)Cc1ccccc1,benzene_ring
49945,Remove a halo from the molecule C[C@@H](Oc1ccc(Cl)cc1)C(=O)Nc1ccc(NC(=O)c2ccccc2)cc1.,C[C@@H](Oc1ccc(Cl)cc1)C(=O)Nc1ccc(NC(=O)c2ccccc2)cc1,halo
182163,Remove a benzene_ring from the molecule CCOc1ccc(N2CCn3c2nn(CC(=O)N2CCCCCC2)c(=O)c3=O)cc1.,CCOc1ccc(N2CCn3c2nn(CC(=O)N2CCCCCC2)c(=O)c3=O)cc1,benzene_ring
136059,Please remove a amide from the molecule C[C@H]1CCC[NH+](C(C)(C)CNC(=O)/C=C/c2ccc3c(c2)OCO3)C1.,C[C@H]1CCC[NH+](C(C)(C)CNC(=O)/C=C/c2ccc3c(c2)OCO3)C1,amide
136893,Modify the molecule CCn1/c(=N/C(=O)CN2C(=O)CCC2=O)sc2cc(F)cc(F)c21 by removing a halo.,CCn1/c(=N/C(=O)CN2C(=O)CCC2=O)sc2cc(F)cc(F)c21,halo
97434,Remove a halo from the molecule CN1CCN(C(=O)CCCN2C(=O)/C(=C/c3cccc(Br)c3)SC2=S)CC1.,CN1CCN(C(=O)CCCN2C(=O)/C(=C/c3cccc(Br)c3)SC2=S)CC1,halo
101316,Modify the molecule CO/N=C(/C(=O)Nc1cc(C(N)=O)c(F)cc1F)c1ccco1 by removing a halo.,CO/N=C(/C(=O)Nc1cc(C(N)=O)c(F)cc1F)c1ccco1,halo
73639,Remove a benzene_ring from the molecule CCOc1ccc(/N=C2/C(=O)N(CN3CCOCC3)c3ccccc32)cc1.,CCOc1ccc(/N=C2/C(=O)N(CN3CCOCC3)c3ccccc32)cc1,benzene_ring
48440,Modify the molecule NC1=NC(=O)[C@H](c2ccc(Br)cc2)C([O-])=N1 by removing a benzene_ring.,NC1=NC(=O)[C@H](c2ccc(Br)cc2)C([O-])=N1,benzene_ring
242407,Please remove a amide from the molecule COc1ccccc1NC(=O)c1ccc(NC(=O)C[NH+]2CCC[C@H]2c2ccc3c(c2)OCCO3)cc1.,COc1ccccc1NC(=O)c1ccc(NC(=O)C[NH+]2CCC[C@H]2c2ccc3c(c2)OCCO3)cc1,amide
96234,Please remove a benzene_ring from the molecule Cc1ccc(NC(=O)C(C)C)cc1NCC(=O)N1C[C@@H](C)O[C@H](C)C1.,Cc1ccc(NC(=O)C(C)C)cc1NCC(=O)N1C[C@@H](C)O[C@H](C)C1,benzene_ring
131159,Modify the molecule C[C@H]1CCc2c(C(=O)N3CCN(c4cc[nH+]cc4)CC3)csc2C1 by removing a amide.,C[C@H]1CCc2c(C(=O)N3CCN(c4cc[nH+]cc4)CC3)csc2C1,amide
63231,Modify the molecule CC(=O)Nn1c(C)cc(CN2CCN(c3[nH+]cccc3C)CC2)c1C by removing a amide.,CC(=O)Nn1c(C)cc(CN2CCN(c3[nH+]cccc3C)CC2)c1C,amide
131127,Remove a benzene_ring from the molecule Cc1ccc(O)c(C(=O)NCc2ccc(-c3csc(C)n3)s2)c1.,Cc1ccc(O)c(C(=O)NCc2ccc(-c3csc(C)n3)s2)c1,benzene_ring
21627,Modify the molecule O=C(NC[C@]1(O)CCOc2ccccc21)C1CCC1 by removing a hydroxyl.,O=C(NC[C@]1(O)CCOc2ccccc21)C1CCC1,hydroxyl
199758,Modify the molecule CCCn1c(C)nn(CN2CCO[C@@H](c3ccccc3Cl)C2)c1=S by removing a halo.,CCCn1c(C)nn(CN2CCO[C@@H](c3ccccc3Cl)C2)c1=S,halo
176082,Modify the molecule C[C@H](CO)N(C)C(=O)CCn1cnc2sc3c(c2c1=O)CCCC3 by removing a hydroxyl.,C[C@H](CO)N(C)C(=O)CCn1cnc2sc3c(c2c1=O)CCCC3,hydroxyl
32457,Modify the molecule CCc1cccc(NC(=O)c2cn(-c3ccc(-c4noc(C5CC5)n4)cc3)nc2C)c1 by removing a benzene_ring.,CCc1cccc(NC(=O)c2cn(-c3ccc(-c4noc(C5CC5)n4)cc3)nc2C)c1,benzene_ring
169324,Please remove a benzene_ring from the molecule COc1ccc(-c2csc(Nc3ncccc3C)n2)cc1OC.,COc1ccc(-c2csc(Nc3ncccc3C)n2)cc1OC,benzene_ring
93493,Please remove a amine from the molecule CC[C@@H](C)CN(CC)c1ncnc2ccc(N)cc12.,CC[C@@H](C)CN(CC)c1ncnc2ccc(N)cc12,amine
187404,Please remove a benzene_ring from the molecule CCc1cnc(CCNC(=O)Nc2cc(OC)ccc2F)s1.,CCc1cnc(CCNC(=O)Nc2cc(OC)ccc2F)s1,benzene_ring
200840,Modify the molecule CCC[C@H]1C[C@]1(O)c1cscn1 by removing a hydroxyl.,CCC[C@H]1C[C@]1(O)c1cscn1,hydroxyl
79696,Remove a amide from the molecule CC(=O)Nc1ccc(-c2nc(Cn3cccn3)c(C)o2)cc1.,CC(=O)Nc1ccc(-c2nc(Cn3cccn3)c(C)o2)cc1,amide
227504,Modify the molecule Cc1cccn2c(=O)c(C(=O)NC[C@@H](C)CN3CCOCC3)cnc12 by removing a amide.,Cc1cccn2c(=O)c(C(=O)NC[C@@H](C)CN3CCOCC3)cnc12,amide
48366,Please remove a halo from the molecule Cc1cc(C)n2c(CN(CC(F)F)C3CC3)cnc2n1.,Cc1cc(C)n2c(CN(CC(F)F)C3CC3)cnc2n1,halo
104181,Modify the molecule CCOC(=O)C1=C(N)OC2=C(C(=O)CC(C)(C)C2)[C@H]1c1c(OCC)ccc2ccccc12 by removing a amine.,CCOC(=O)C1=C(N)OC2=C(C(=O)CC(C)(C)C2)[C@H]1c1c(OCC)ccc2ccccc12,amine
189984,Please remove a benzene_ring from the molecule COc1ccc([C@@H]2CC(=O)C(/C=N/C3Cc4ccccc4C3)=C([O-])C2)cc1OC.,COc1ccc([C@@H]2CC(=O)C(/C=N/C3Cc4ccccc4C3)=C([O-])C2)cc1OC,benzene_ring
141677,Modify the molecule C[C@H]1CC(C(=O)N[C@@H]2CCc3c2ccc(Cl)c3Cl)C[C@@H](C)O1 by removing a halo.,C[C@H]1CC(C(=O)N[C@@H]2CCc3c2ccc(Cl)c3Cl)C[C@@H](C)O1,halo
66610,Remove a amide from the molecule CCOc1ccccc1CN1CCN(c2cccc3c2C(=O)N(CC2(O)CCCCC2)C3=O)CC1.,CCOc1ccccc1CN1CCN(c2cccc3c2C(=O)N(CC2(O)CCCCC2)C3=O)CC1,amide
8405,Remove a benzene_ring from the molecule COc1ccc(CC(=O)N2CCN(S(=O)(=O)c3ccc4c(c3)sc(=O)n4C)CC2)cc1OC.,COc1ccc(CC(=O)N2CCN(S(=O)(=O)c3ccc4c(c3)sc(=O)n4C)CC2)cc1OC,benzene_ring
115858,Remove a benzene_ring from the molecule CCNC(=O)NNC(=O)[C@H]1CCC(=O)N(c2ccc(C)c(C)c2)C1.,CCNC(=O)NNC(=O)[C@H]1CCC(=O)N(c2ccc(C)c(C)c2)C1,benzene_ring
118526,Please remove a halo from the molecule Cc1nnc(C[NH+](Cc2c(F)cccc2N2CCCC2)C(C)(C)C)o1.,Cc1nnc(C[NH+](Cc2c(F)cccc2N2CCCC2)C(C)(C)C)o1,halo
42730,Please remove a benzene_ring from the molecule COc1ccc(-c2n[nH]c(CC(C)C)c2NC(=O)c2cccc(Cl)c2)cc1OC.,COc1ccc(-c2n[nH]c(CC(C)C)c2NC(=O)c2cccc(Cl)c2)cc1OC,benzene_ring
46195,Remove a amide from the molecule O=C(Nc1ccccc1OCC(F)(F)F)C(=O)N[C@@H]1CCc2ccccc21.,O=C(Nc1ccccc1OCC(F)(F)F)C(=O)N[C@@H]1CCc2ccccc21,amide
110956,Please remove a amide from the molecule C[C@H](NC(=O)C(C)(C)c1ccccc1)c1ccc2c(c1)OCCO2.,C[C@H](NC(=O)C(C)(C)c1ccccc1)c1ccc2c(c1)OCCO2,amide
226418,Modify the molecule CC(=O)Nc1nnc(-c2cccc(SC(C)C)c2)o1 by removing a amide.,CC(=O)Nc1nnc(-c2cccc(SC(C)C)c2)o1,amide
115835,Modify the molecule CC[C@H](NC(=O)N[C@H](C)Cc1c(C)nn(C)c1C)C(C)(C)c1ccccc1 by removing a benzene_ring.,CC[C@H](NC(=O)N[C@H](C)Cc1c(C)nn(C)c1C)C(C)(C)c1ccccc1,benzene_ring
11886,Please remove a amide from the molecule O=C1CC[C@H](COC(=O)[C@@H]2CCCN2C(=O)C23CC4CC(CC(C4)C2)C3)N1.,O=C1CC[C@H](COC(=O)[C@@H]2CCCN2C(=O)C23CC4CC(CC(C4)C2)C3)N1,amide
180750,Remove a benzene_ring from the molecule Cc1ccc([S@@](=O)Cc2nnc(-c3ccccc3C)o2)c(C)c1.,Cc1ccc([S@@](=O)Cc2nnc(-c3ccccc3C)o2)c(C)c1,benzene_ring
28490,Remove a nitro from the molecule C=CCN1C(=O)S/C(=C/c2ccccc2[N+](=O)[O-])C1=O.,C=CCN1C(=O)S/C(=C/c2ccccc2[N+](=O)[O-])C1=O,nitro
55918,Remove a benzene_ring from the molecule COc1ccc(C(C)=O)cc1CC(=O)N[C@H](C)c1cn(C)nc1C.,COc1ccc(C(C)=O)cc1CC(=O)N[C@H](C)c1cn(C)nc1C,benzene_ring
99980,Modify the molecule Cc1sc(NC(=O)c2ccccc2)c(CN2CCc3ccccc3C2)c1C by removing a amide.,Cc1sc(NC(=O)c2ccccc2)c(CN2CCc3ccccc3C2)c1C,amide
177221,Please remove a benzene_ring from the molecule COCCC[C@]1(CO)CCCN(S(=O)(=O)c2ccc(C)c(F)c2)C1.,COCCC[C@]1(CO)CCCN(S(=O)(=O)c2ccc(C)c(F)c2)C1,benzene_ring
238047,Please remove a halo from the molecule O=C1C[C@@H]([NH2+]CCC2=CCCCC2)C(=O)N1c1cccc(Cl)c1Cl.,O=C1C[C@@H]([NH2+]CCC2=CCCCC2)C(=O)N1c1cccc(Cl)c1Cl,halo
16193,Modify the molecule O=c1ccc(-c2ccc(Br)cc2)nn1Cc1ccc(F)cc1 by removing a halo.,O=c1ccc(-c2ccc(Br)cc2)nn1Cc1ccc(F)cc1,halo
112110,Remove a amide from the molecule CCCCN1C(=O)[C@@H](C(=O)Nc2nc3ccccc3[nH]2)[C@H](O)c2ccccc21.,CCCCN1C(=O)[C@@H](C(=O)Nc2nc3ccccc3[nH]2)[C@H](O)c2ccccc21,amide
23491,Modify the molecule COc1cc(N2CC[NH+](C)[C@@]3(CCNC(=O)CC3)C2)nc(OC)n1 by removing a amide.,COc1cc(N2CC[NH+](C)[C@@]3(CCNC(=O)CC3)C2)nc(OC)n1,amide
92226,Please remove a amine from the molecule CC[C@H](C[NH3+])Nc1nc2ccc(Br)cn2n1.,CC[C@H](C[NH3+])Nc1nc2ccc(Br)cn2n1,amine
211148,Please remove a amide from the molecule Cc1ccc2c(c1)[C@H](CC(=O)N(C)Cc1ccno1)C(=O)N2.,Cc1ccc2c(c1)[C@H](CC(=O)N(C)Cc1ccno1)C(=O)N2,amide
93617,Modify the molecule Cc1cccc(-n2c(SCC(=O)N[C@@H]3CCS(=O)(=O)C3)nc3sc(C)c(C)c3c2=O)c1 by removing a benzene_ring.,Cc1cccc(-n2c(SCC(=O)N[C@@H]3CCS(=O)(=O)C3)nc3sc(C)c(C)c3c2=O)c1,benzene_ring
105300,Modify the molecule COc1cc([C@H](C)NC2CC[NH+](C)CC2)ccc1O by removing a hydroxyl.,COc1cc([C@H](C)NC2CC[NH+](C)CC2)ccc1O,hydroxyl
165511,Remove a halo from the molecule COC[C@@H](Cl)CN(C)C[C@@H]1COc2ccccc21.,COC[C@@H](Cl)CN(C)C[C@@H]1COc2ccccc21,halo
187732,Modify the molecule CC(C)C[C@H](Nc1cnn(C)c(=O)c1Cl)C(=O)Nc1nccs1 by removing a amide.,CC(C)C[C@H](Nc1cnn(C)c(=O)c1Cl)C(=O)Nc1nccs1,amide
196674,Remove a amide from the molecule CC(C)OCC[NH+]1CCC(NC(=O)CN2CCCCC2=O)CC1.,CC(C)OCC[NH+]1CCC(NC(=O)CN2CCCCC2=O)CC1,amide
211293,Modify the molecule C[NH+](CC(=O)NC(=O)NCc1ccco1)C[C@@H]1COc2ccccc2O1 by removing a amide.,C[NH+](CC(=O)NC(=O)NCc1ccco1)C[C@@H]1COc2ccccc2O1,amide
5892,Modify the molecule O=C(OCC(=O)N1CCCC1)c1cn(-c2ccccc2)nc1-c1ccc(F)cc1 by removing a halo.,O=C(OCC(=O)N1CCCC1)c1cn(-c2ccccc2)nc1-c1ccc(F)cc1,halo
22358,Remove a amide from the molecule C[C@H](C(=O)Nc1cccc([N+](=O)[O-])c1)N1C(=O)c2ccccc2C1=O.,C[C@H](C(=O)Nc1cccc([N+](=O)[O-])c1)N1C(=O)c2ccccc2C1=O,amide
204815,Modify the molecule CCN(C[C@H](C)C#N)C(=O)Cn1cnc2c(cnn2-c2ccccc2)c1=O by removing a benzene_ring.,CCN(C[C@H](C)C#N)C(=O)Cn1cnc2c(cnn2-c2ccccc2)c1=O,benzene_ring
204493,Modify the molecule Cc1nc(N2CCC(C(=O)NCc3ccccc3Cl)CC2)nc2cc(S(C)(=O)=O)ccc12 by removing a benzene_ring.,Cc1nc(N2CCC(C(=O)NCc3ccccc3Cl)CC2)nc2cc(S(C)(=O)=O)ccc12,benzene_ring
66546,Remove a amide from the molecule Cc1ccc2nc(NC(=O)CSc3nnc(Cn4c(=O)sc5ccccc54)n3C)sc2c1.,Cc1ccc2nc(NC(=O)CSc3nnc(Cn4c(=O)sc5ccccc54)n3C)sc2c1,amide
44411,Modify the molecule CN(C)c1ccc(-n2nc3ccc(NC(=O)c4cc([N+](=O)[O-])ccc4Br)cc3n2)cc1 by removing a nitro.,CN(C)c1ccc(-n2nc3ccc(NC(=O)c4cc([N+](=O)[O-])ccc4Br)cc3n2)cc1,nitro
169801,Remove a amide from the molecule Cc1nc(CN(C)C(=O)c2cnn(-c3nccc(-c4ccco4)n3)c2C)cs1.,Cc1nc(CN(C)C(=O)c2cnn(-c3nccc(-c4ccco4)n3)c2C)cs1,amide
176723,Remove a benzene_ring from the molecule CC[C@@H](C(=O)Nc1c(C(=O)OC)[nH]c2ccc(C)cc12)c1ccccc1.,CC[C@@H](C(=O)Nc1c(C(=O)OC)[nH]c2ccc(C)cc12)c1ccccc1,benzene_ring
52384,Remove a benzene_ring from the molecule C=CCN(Cc1cccc(C#N)c1)Cc1c[nH]nc1-c1ccc2c(c1)OCCO2.,C=CCN(Cc1cccc(C#N)c1)Cc1c[nH]nc1-c1ccc2c(c1)OCCO2,benzene_ring
58145,Please remove a halo from the molecule O=C(NCc1cccc(Cl)c1)C(=O)N[C@H]1CCCCNC1=O.,O=C(NCc1cccc(Cl)c1)C(=O)N[C@H]1CCCCNC1=O,halo
126141,Remove a amide from the molecule CC[C@](C)(NC(=O)CCOC1CCOCC1)c1nccs1.,CC[C@](C)(NC(=O)CCOC1CCOCC1)c1nccs1,amide
176148,Modify the molecule Cc1cc(OCC(=O)NNC(=O)[C@H](C)Oc2ccc(Cl)cc2Cl)ccc1Cl by removing a amide.,Cc1cc(OCC(=O)NNC(=O)[C@H](C)Oc2ccc(Cl)cc2Cl)ccc1Cl,amide
190315,Remove a amide from the molecule O=C(Cc1ccc(-n2cccc2)cc1)NCc1csc(C2CC2)n1.,O=C(Cc1ccc(-n2cccc2)cc1)NCc1csc(C2CC2)n1,amide
47466,Remove a benzene_ring from the molecule CCOc1cccc2sc(N3CCN(C(=O)/C=C/c4ccccc4Cl)CC3)nc12.,CCOc1cccc2sc(N3CCN(C(=O)/C=C/c4ccccc4Cl)CC3)nc12,benzene_ring
71649,Modify the molecule C[C@H](CCCO)N[C@H]1C[NH+]2CCC1CC2 by removing a hydroxyl.,C[C@H](CCCO)N[C@H]1C[NH+]2CCC1CC2,hydroxyl
65169,Please remove a amide from the molecule O=C(NCCCCN1CCOCC1)c1csc2c1CCCC2.,O=C(NCCCCN1CCOCC1)c1csc2c1CCCC2,amide
49553,Modify the molecule Cn1cc(C(=O)N2CCCCC2)cc(NC(=O)c2cc(=O)c3ccccc3o2)c1=O by removing a amide.,Cn1cc(C(=O)N2CCCCC2)cc(NC(=O)c2cc(=O)c3ccccc3o2)c1=O,amide
72018,Please remove a amide from the molecule CC(C)[C@@H](O)CNC(=O)C(=O)Nc1ccc2[nH]c(C(F)F)nc2c1.,CC(C)[C@@H](O)CNC(=O)C(=O)Nc1ccc2[nH]c(C(F)F)nc2c1,amide
84799,Modify the molecule COc1ccccc1[C@H](C)NC(=O)[C@H](C)SCC(C)C by removing a benzene_ring.,COc1ccccc1[C@H](C)NC(=O)[C@H](C)SCC(C)C,benzene_ring
134402,Please remove a amide from the molecule COc1ccc(/C=N/NC(=O)CC#N)cc1Br.,COc1ccc(/C=N/NC(=O)CC#N)cc1Br,amide
187285,Remove a benzene_ring from the molecule O=[S@@](CCN1CCCN(Cc2cccs2)CC1)c1ccccc1.,O=[S@@](CCN1CCCN(Cc2cccs2)CC1)c1ccccc1,benzene_ring
205982,Remove a nitrile from the molecule N#Cc1ccc(/C=C\c2[nH+]ccc3c2[nH]c2ccccc23)cc1.,N#Cc1ccc(/C=C\c2[nH+]ccc3c2[nH]c2ccccc23)cc1,nitrile
218437,Please remove a amide from the molecule O=C(c1ccccc1)N1C[C@@H]2CC[C@H](C1)N(C(=O)CCc1ccccn1)C2.,O=C(c1ccccc1)N1C[C@@H]2CC[C@H](C1)N(C(=O)CCc1ccccn1)C2,amide
191046,Please remove a nitrile from the molecule N#CCCN(Cc1ccccn1)Cc1n[nH]c(=O)[nH]1.,N#CCCN(Cc1ccccn1)Cc1n[nH]c(=O)[nH]1,nitrile
304,Modify the molecule O=C(c1cccs1)N(Cc1ccc(F)cc1)Cc1cc(-c2ccccc2)cn2nnnc12 by removing a amide.,O=C(c1cccs1)N(Cc1ccc(F)cc1)Cc1cc(-c2ccccc2)cn2nnnc12,amide
117282,Modify the molecule CN(C)c1ccc([C@H](CNC(=O)C(=O)Nc2ccccc2F)N2CCc3ccccc32)cc1 by removing a halo.,CN(C)c1ccc([C@H](CNC(=O)C(=O)Nc2ccccc2F)N2CCc3ccccc32)cc1,halo
21600,Remove a amide from the molecule O=C([O-])CNC(=O)/C=C/c1cccs1.,O=C([O-])CNC(=O)/C=C/c1cccs1,amide
210050,Please remove a halo from the molecule C[C@H]1CCC[C@](O)(CNC(=O)Cc2c(F)cccc2F)C1.,C[C@H]1CCC[C@](O)(CNC(=O)Cc2c(F)cccc2F)C1,halo
162744,Remove a benzene_ring from the molecule C/C(=N\NC(N)=S)c1ccc(O)cc1O.,C/C(=N\NC(N)=S)c1ccc(O)cc1O,benzene_ring
49951,Remove a amide from the molecule Cc1cc2c(n1-c1ccc(C(=O)NCc3ccccc3)cc1)CCCC2.,Cc1cc2c(n1-c1ccc(C(=O)NCc3ccccc3)cc1)CCCC2,amide
147902,Modify the molecule C[C@H](C[C@H]1CCC[NH2+]C1)c1ccccc1 by removing a benzene_ring.,C[C@H](C[C@H]1CCC[NH2+]C1)c1ccccc1,benzene_ring
194241,Remove a nitrile from the molecule N#Cc1csc(C[NH2+][C@H]2CCC[C@@H](OCC(F)(F)F)C2)c1.,N#Cc1csc(C[NH2+][C@H]2CCC[C@@H](OCC(F)(F)F)C2)c1,nitrile
200930,Modify the molecule CCc1c(C)sc(NC(=S)N2CC[NH+]3CCC[C@H]3C2)c1C(=O)OC by removing a amine.,CCc1c(C)sc(NC(=S)N2CC[NH+]3CCC[C@H]3C2)c1C(=O)OC,amine
86448,Please remove a halo from the molecule O[C@H]1C[C@@H](c2cc(F)ccc2F)N(Cc2cnc(C3CC3)s2)C1.,O[C@H]1C[C@@H](c2cc(F)ccc2F)N(Cc2cnc(C3CC3)s2)C1,halo
247401,Remove a hydroxyl from the molecule Cc1csc(C[C@H](O)Cc2nccs2)n1.,Cc1csc(C[C@H](O)Cc2nccs2)n1,hydroxyl
169721,Remove a benzene_ring from the molecule COc1cccc(CNC(=O)[C@H](C)Sc2nc(C)nc3ccccc23)c1.,COc1cccc(CNC(=O)[C@H](C)Sc2nc(C)nc3ccccc23)c1,benzene_ring
85029,Remove a amide from the molecule O=C(N[C@H]1C(=O)N/[N+](=C\c2ccc(Br)cc2)[C@H]1c1ccccc1)c1ccc(F)cc1.,O=C(N[C@H]1C(=O)N/[N+](=C\c2ccc(Br)cc2)[C@H]1c1ccccc1)c1ccc(F)cc1,amide
136361,Please remove a benzene_ring from the molecule CC[C@@H](C)NC(=O)c1cccc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)[O-])c1.,CC[C@@H](C)NC(=O)c1cccc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)[O-])c1,benzene_ring
43131,Please remove a amide from the molecule O=C(c1ccc(NS(=O)(=O)c2ccccc2)cc1)N1CCc2ccccc2C1.,O=C(c1ccc(NS(=O)(=O)c2ccccc2)cc1)N1CCc2ccccc2C1,amide
32348,Modify the molecule CC1=C(C)C[C@@H](C(=O)NNC(=O)c2sccc2C)[C@@H](C(=O)[O-])C1 by removing a amide.,CC1=C(C)C[C@@H](C(=O)NNC(=O)c2sccc2C)[C@@H](C(=O)[O-])C1,amide
246693,Please remove a amide from the molecule Cc1ncc(Cl)c(C(=O)N[C@H]2CC[C@H]([NH+](C)C)C2)n1.,Cc1ncc(Cl)c(C(=O)N[C@H]2CC[C@H]([NH+](C)C)C2)n1,amide
92630,Please remove a benzene_ring from the molecule O=C(Cc1cccs1)NCCOc1ccc2nnc(-c3ccccc3)n2n1.,O=C(Cc1cccs1)NCCOc1ccc2nnc(-c3ccccc3)n2n1,benzene_ring
184459,Remove a halo from the molecule CCOC(=O)[C@H](C)Nc1cc(-n2ncc(=O)n(C)c2=O)c(F)cc1F.,CCOC(=O)[C@H](C)Nc1cc(-n2ncc(=O)n(C)c2=O)c(F)cc1F,halo
101987,Please remove a halo from the molecule O=C(Nc1ccc(NC(=O)c2ccccc2Cl)cc1)c1cccnc1.,O=C(Nc1ccc(NC(=O)c2ccccc2Cl)cc1)c1cccnc1,halo
29064,Modify the molecule N/C(CCCSc1ccccc1[N+](=O)[O-])=N\O by removing a nitro.,N/C(CCCSc1ccccc1[N+](=O)[O-])=N\O,nitro
67827,Modify the molecule C[C@@H](NC1=[NH+]CCC1)C(=O)[O-] by removing a amine.,C[C@@H](NC1=[NH+]CCC1)C(=O)[O-],amine
31805,Please remove a nitro from the molecule COc1cccc(N2C(=O)c3oc4ccccc4c(=O)c3[C@H]2c2cccc([N+](=O)[O-])c2)c1.,COc1cccc(N2C(=O)c3oc4ccccc4c(=O)c3[C@H]2c2cccc([N+](=O)[O-])c2)c1,nitro
134741,Please remove a amide from the molecule Cc1ccc(S(C)(=O)=O)cc1C(=O)NCCOCC(=O)[O-].,Cc1ccc(S(C)(=O)=O)cc1C(=O)NCCOCC(=O)[O-],amide
449,Remove a halo from the molecule COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1.,COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1,halo
51606,Modify the molecule CCOCCn1c(NN)nc2c1c(=O)n(C)c(=O)n2C by removing a amine.,CCOCCn1c(NN)nc2c1c(=O)n(C)c(=O)n2C,amine
176348,Please remove a benzene_ring from the molecule O=C(Nc1ccc(Oc2ccc(Br)cc2)cc1)c1cnc2n(c1=O)CCS2.,O=C(Nc1ccc(Oc2ccc(Br)cc2)cc1)c1cnc2n(c1=O)CCS2,benzene_ring
96892,Modify the molecule COc1ccc(NCc2ccccc2C#N)c(OC)c1 by removing a amine.,COc1ccc(NCc2ccccc2C#N)c(OC)c1,amine
226716,Modify the molecule COc1cccc(C[NH+]2CCNC(=O)[C@@H]2CC(=O)N2CCNC(=O)C2)c1 by removing a benzene_ring.,COc1cccc(C[NH+]2CCNC(=O)[C@@H]2CC(=O)N2CCNC(=O)C2)c1,benzene_ring
149521,Remove a amine from the molecule CCn1c([C@@H](C)NC[C@@H](C2CC2)[NH+](C)C)nc2ccccc21.,CCn1c([C@@H](C)NC[C@@H](C2CC2)[NH+](C)C)nc2ccccc21,amine
247113,Please remove a halo from the molecule Clc1ccc(-c2cnc3cccnc3n2)s1.,Clc1ccc(-c2cnc3cccnc3n2)s1,halo
111995,Remove a benzene_ring from the molecule O=C(NCCc1ccc(F)cc1)NC[C@@H]1CC[NH+](C2CC2)C1.,O=C(NCCc1ccc(F)cc1)NC[C@@H]1CC[NH+](C2CC2)C1,benzene_ring
187630,Remove a halo from the molecule NC(=O)c1ccc(CSCCOc2ccc(F)cc2Cl)cc1.,NC(=O)c1ccc(CSCCOc2ccc(F)cc2Cl)cc1,halo
129018,Please remove a halo from the molecule O=C(CN1CCN(C(=O)c2cccc(Cl)c2Cl)CC1)NCC1CC1.,O=C(CN1CCN(C(=O)c2cccc(Cl)c2Cl)CC1)NCC1CC1,halo
249414,Modify the molecule O=C(c1ccc(N2C(=O)CCC2=O)cc1)N1CCN(S(=O)(=O)c2ccccc2Cl)CC1 by removing a benzene_ring.,O=C(c1ccc(N2C(=O)CCC2=O)cc1)N1CCN(S(=O)(=O)c2ccccc2Cl)CC1,benzene_ring
228977,Modify the molecule Cc1ccc(CN2CCO[C@H](c3nccs3)C2)cc1F by removing a benzene_ring.,Cc1ccc(CN2CCO[C@H](c3nccs3)C2)cc1F,benzene_ring
101667,Please remove a benzene_ring from the molecule C=CCOc1cccc(NC(=O)[C@@H](C)Oc2cccc(C)c2)c1.,C=CCOc1cccc(NC(=O)[C@@H](C)Oc2cccc(C)c2)c1,benzene_ring
128964,Remove a halo from the molecule C#CCn1/c(=N\C(=O)C2CCN(S(C)(=O)=O)CC2)sc2cc(F)ccc21.,C#CCn1/c(=N\C(=O)C2CCN(S(C)(=O)=O)CC2)sc2cc(F)ccc21,halo
115492,Remove a amine from the molecule COc1ccc2nc(/N=C(\N)NC(=S)Nc3ccc(Cl)cc3)nc(C)c2c1.,COc1ccc2nc(/N=C(\N)NC(=S)Nc3ccc(Cl)cc3)nc(C)c2c1,amine
100549,Please remove a amine from the molecule CCCCSc1nc2n(n1)[C@@H](c1sccc1C)C(C(C)=O)=C(C)N2.,CCCCSc1nc2n(n1)[C@@H](c1sccc1C)C(C(C)=O)=C(C)N2,amine
117440,Modify the molecule Cc1cc(C)cc(C2=CC[NH+](C[C@@H](O)COC[C@@H]3CCCO3)CC2)c1 by removing a benzene_ring.,Cc1cc(C)cc(C2=CC[NH+](C[C@@H](O)COC[C@@H]3CCCO3)CC2)c1,benzene_ring
162182,Remove a amide from the molecule CN(C(=O)/C=C/c1cccnc1)c1cccc2ncccc12.,CN(C(=O)/C=C/c1cccnc1)c1cccc2ncccc12,amide
135899,Please remove a benzene_ring from the molecule CCCn1c(SCc2ccccc2)nnc1-c1ccncc1.,CCCn1c(SCc2ccccc2)nnc1-c1ccncc1,benzene_ring
49130,Modify the molecule CC(=O)N(Cc1ccc(NC(=O)[C@@H]2CCCC[NH+]2C)cc1)C1CC1 by removing a amide.,CC(=O)N(Cc1ccc(NC(=O)[C@@H]2CCCC[NH+]2C)cc1)C1CC1,amide
199049,Please remove a benzene_ring from the molecule c1ccc(-n2cnc(C[NH+]3CC[C@@]4(CCOC4)C3)n2)cc1.,c1ccc(-n2cnc(C[NH+]3CC[C@@]4(CCOC4)C3)n2)cc1,benzene_ring
48940,Remove a benzene_ring from the molecule O=C(NCc1ccc(N2CCOCC2)cc1)Nc1cncc2ccccc12.,O=C(NCc1ccc(N2CCOCC2)cc1)Nc1cncc2ccccc12,benzene_ring
95572,Please remove a benzene_ring from the molecule Cc1ccc(N2/C(=N/C(=O)CCNC(=O)OC(C)(C)C)S[C@H]3CS(=O)(=O)C[C@@H]32)cc1F.,Cc1ccc(N2/C(=N/C(=O)CCNC(=O)OC(C)(C)C)S[C@H]3CS(=O)(=O)C[C@@H]32)cc1F,benzene_ring
89567,Modify the molecule NN1C(SCC(=O)Nc2ccc(Cl)cc2)=NN[C@@H]1[C@@H]1N=NC2=C1CCC2 by removing a amine.,NN1C(SCC(=O)Nc2ccc(Cl)cc2)=NN[C@@H]1[C@@H]1N=NC2=C1CCC2,amine
120315,Modify the molecule COC(=O)c1cccc(S(=O)(=O)NCc2csc(C3CC3)n2)c1 by removing a amine.,COC(=O)c1cccc(S(=O)(=O)NCc2csc(C3CC3)n2)c1,amine
37725,Modify the molecule Cc1ccc([C@@H]([C@@H](C)[NH3+])N2CCN(C)C(=O)C2(C)C)cc1 by removing a benzene_ring.,Cc1ccc([C@@H]([C@@H](C)[NH3+])N2CCN(C)C(=O)C2(C)C)cc1,benzene_ring
82749,Remove a benzene_ring from the molecule Cn1ncnc1CCNS(=O)(=O)c1cccc(C#N)c1.,Cn1ncnc1CCNS(=O)(=O)c1cccc(C#N)c1,benzene_ring
83067,Modify the molecule Cc1ccc(C(=O)N[C@H](C#N)c2cccc(Cl)c2Cl)cc1[N-]S(C)(=O)=O by removing a amide.,Cc1ccc(C(=O)N[C@H](C#N)c2cccc(Cl)c2Cl)cc1[N-]S(C)(=O)=O,amide
143102,Modify the molecule CN(CC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)CSc1ccc([N+](=O)[O-])cc1 by removing a amide.,CN(CC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)CSc1ccc([N+](=O)[O-])cc1,amide
148717,Modify the molecule CN1CC[C@@]2(CCC1=O)CN(C(=O)CCN(C)S(C)(=O)=O)CCN2C by removing a amide.,CN1CC[C@@]2(CCC1=O)CN(C(=O)CCN(C)S(C)(=O)=O)CCN2C,amide
151059,Please remove a benzene_ring from the molecule Cc1cc(C)c(CNC(=O)N(C)Cc2cn(-c3ccccc3)nc2-c2ccccc2)c(=O)[nH]1.,Cc1cc(C)c(CNC(=O)N(C)Cc2cn(-c3ccccc3)nc2-c2ccccc2)c(=O)[nH]1,benzene_ring
65505,Modify the molecule C#CCN(C(=O)Cc1cccc(OCC#N)c1)C1CCCC1 by removing a amide.,C#CCN(C(=O)Cc1cccc(OCC#N)c1)C1CCCC1,amide
175765,Remove a hydroxyl from the molecule O=C(Cn1ccc(=O)c2ccccc21)N[C@@H]1c2ccccc2C[C@@H]1O.,O=C(Cn1ccc(=O)c2ccccc21)N[C@@H]1c2ccccc2C[C@@H]1O,hydroxyl
8365,Please remove a amide from the molecule CC[NH+]1CCC(CC(=O)N[C@H](C(=O)[O-])c2ccc(F)cc2F)CC1.,CC[NH+]1CCC(CC(=O)N[C@H](C(=O)[O-])c2ccc(F)cc2F)CC1,amide
6653,Remove a hydroxyl from the molecule C[C@@H](CCO)[NH2+][C@@H]1CCc2[nH]c3ccccc3c2C1.,C[C@@H](CCO)[NH2+][C@@H]1CCc2[nH]c3ccccc3c2C1,hydroxyl
17786,Please remove a amine from the molecule CNc1cc[nH+]c(CN2CCC[C@H](C)C2)c1.,CNc1cc[nH+]c(CN2CCC[C@H](C)C2)c1,amine
241378,Modify the molecule C[C@H](NC(=O)C[NH+](C)Cc1nc2ccccc2n1C)c1ccco1 by removing a amide.,C[C@H](NC(=O)C[NH+](C)Cc1nc2ccccc2n1C)c1ccco1,amide
66876,Modify the molecule COc1ccc(CC(=O)Nc2nonc2-c2ccc(OC(C)C)cc2)cc1 by removing a benzene_ring.,COc1ccc(CC(=O)Nc2nonc2-c2ccc(OC(C)C)cc2)cc1,benzene_ring
14155,Remove a amide from the molecule CC[C@](C)(NC(=O)c1ccc2ccccc2c1O)C(=O)[O-].,CC[C@](C)(NC(=O)c1ccc2ccccc2c1O)C(=O)[O-],amide
158593,Remove a amine from the molecule CC[NH+](Cc1nc2c(N)cccc2o1)C[C@@H](C)C#N.,CC[NH+](Cc1nc2c(N)cccc2o1)C[C@@H](C)C#N,amine
589,Remove a amide from the molecule CC[C@@H](C)N(CC)C(=O)c1ccccc1N.,CC[C@@H](C)N(CC)C(=O)c1ccccc1N,amide
99115,Remove a halo from the molecule C[C@H](NC(=O)c1cc([N+](=O)[O-])ccc1Cl)c1ccc(F)c(F)c1.,C[C@H](NC(=O)c1cc([N+](=O)[O-])ccc1Cl)c1ccc(F)c(F)c1,halo
125694,Modify the molecule CSc1ccc(NC(=O)[C@@H](C)n2nc(-c3cc(C)oc3C)cc(N)c2=O)cc1 by removing a amine.,CSc1ccc(NC(=O)[C@@H](C)n2nc(-c3cc(C)oc3C)cc(N)c2=O)cc1,amine
23931,Please remove a nitrile from the molecule CCOC(=O)c1ccc(CN2CCO[C@H](C#N)C2)o1.,CCOC(=O)c1ccc(CN2CCO[C@H](C#N)C2)o1,nitrile
135941,Please remove a amide from the molecule CCCc1ccc(C(=O)N2C[C@@H](C[NH+](C)C)[C@@H](CO)C2)cc1.,CCCc1ccc(C(=O)N2C[C@@H](C[NH+](C)C)[C@@H](CO)C2)cc1,amide
145238,Modify the molecule C[C@H](CC#N)N1CCc2c(F)ccc(F)c2C1 by removing a halo.,C[C@H](CC#N)N1CCc2c(F)ccc(F)c2C1,halo
52333,Modify the molecule COC[C@@H](C)NC(=O)[C@@H](C)N1C(=O)c2cc(Cl)c(Cl)cc2C1=O by removing a amide.,COC[C@@H](C)NC(=O)[C@@H](C)N1C(=O)c2cc(Cl)c(Cl)cc2C1=O,amide
172342,Remove a amide from the molecule C[C@H]1OCC[C@H]1C(=O)NCc1ccc(C(=O)NCC[NH+](C)C)cc1.,C[C@H]1OCC[C@H]1C(=O)NCc1ccc(C(=O)NCC[NH+](C)C)cc1,amide
169274,Please remove a benzene_ring from the molecule CN(C)c1ccccc1NC(=O)NC1CCCC1.,CN(C)c1ccccc1NC(=O)NC1CCCC1,benzene_ring
81887,Remove a amide from the molecule Cc1ccc([C@@H]2CC(=O)NC3=NC(SCc4ccccc4Cl)=NC(=O)[C@H]32)c(C)c1.,Cc1ccc([C@@H]2CC(=O)NC3=NC(SCc4ccccc4Cl)=NC(=O)[C@H]32)c(C)c1,amide
111656,Modify the molecule C[C@@H](CCNC(=O)c1cccn1-c1cccnc1)[NH+]1CCCCCC1 by removing a amide.,C[C@@H](CCNC(=O)c1cccn1-c1cccnc1)[NH+]1CCCCCC1,amide
196786,Remove a amide from the molecule O=C(NCC1(c2ccccc2Cl)CCOCC1)c1cccc(F)c1F.,O=C(NCC1(c2ccccc2Cl)CCOCC1)c1cccc(F)c1F,amide
170191,Please remove a hydroxyl from the molecule COc1ccc(N(C)C(=O)CCCO)cc1.,COc1ccc(N(C)C(=O)CCCO)cc1,hydroxyl
228339,Remove a amide from the molecule CCOC(=O)C1(C)CCN(C(=O)c2cc(CC)n[nH]2)CC1.,CCOC(=O)C1(C)CCN(C(=O)c2cc(CC)n[nH]2)CC1,amide
135167,Modify the molecule COc1ccc(F)cc1NC(=O)[C@@H]1C[C@H]1c1ccc(C)s1 by removing a benzene_ring.,COc1ccc(F)cc1NC(=O)[C@@H]1C[C@H]1c1ccc(C)s1,benzene_ring
123277,Remove a benzene_ring from the molecule COc1ccc(Cl)cc1C[C@H](O)[C@@H](C)OC.,COc1ccc(Cl)cc1C[C@H](O)[C@@H](C)OC,benzene_ring
235894,Modify the molecule CS(=O)(=O)N1CCC(C(=O)OCc2ccc(-n3cccn3)cc2)CC1 by removing a benzene_ring.,CS(=O)(=O)N1CCC(C(=O)OCc2ccc(-n3cccn3)cc2)CC1,benzene_ring
86690,Please remove a hydroxyl from the molecule C[C@@H]1C[C@](CCO)([C@@H](C)[NH3+])CS1.,C[C@@H]1C[C@](CCO)([C@@H](C)[NH3+])CS1,hydroxyl
227114,Modify the molecule Cc1ccc(NC(=O)CN2CCN(C(=O)CCS(=O)(=O)c3ccc(Cl)cc3)CC2)cc1 by removing a benzene_ring.,Cc1ccc(NC(=O)CN2CCN(C(=O)CCS(=O)(=O)c3ccc(Cl)cc3)CC2)cc1,benzene_ring
194692,Please remove a amide from the molecule Cc1ccc(-n2ccnc2)c(C(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)c1.,Cc1ccc(-n2ccnc2)c(C(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)c1,amide
64081,Please remove a amide from the molecule CN(C)C(=O)CC1CCN(C(=O)C(C)(C)c2ccccc2F)CC1.,CN(C)C(=O)CC1CCN(C(=O)C(C)(C)c2ccccc2F)CC1,amide
7899,Please remove a amide from the molecule C[C@@H]1CCC[C@@H](OCC(=O)NNc2ccc(-c3ccccc3)nn2)C1.,C[C@@H]1CCC[C@@H](OCC(=O)NNc2ccc(-c3ccccc3)nn2)C1,amide
196859,Modify the molecule Cc1cccc(OCCn2c([C@@H]3CC(=O)N(Cc4ccccc4)C3)nc3ccccc32)c1 by removing a benzene_ring.,Cc1cccc(OCCn2c([C@@H]3CC(=O)N(Cc4ccccc4)C3)nc3ccccc32)c1,benzene_ring
91992,Remove a hydroxyl from the molecule CC(C)CC[C@@H](O)[C@H]1CCO[C@]2(CCSC2)C1.,CC(C)CC[C@@H](O)[C@H]1CCO[C@]2(CCSC2)C1,hydroxyl
217902,Modify the molecule CC(C)NC(=O)[C@@H]1CC(=O)N(CCC2=c3cc(F)ccc3=[NH+]C2)C1 by removing a amine.,CC(C)NC(=O)[C@@H]1CC(=O)N(CCC2=c3cc(F)ccc3=[NH+]C2)C1,amine
96111,Modify the molecule C[C@]12CCC(=O)N1[C@H](C(=O)NCc1ccc(Br)cc1F)CS2 by removing a amide.,C[C@]12CCC(=O)N1[C@H](C(=O)NCc1ccc(Br)cc1F)CS2,amide
64374,Remove a hydroxyl from the molecule COc1ccc(C)cc1[C@@H](O)CN1CCN(c2nccs2)CC1.,COc1ccc(C)cc1[C@@H](O)CN1CCN(c2nccs2)CC1,hydroxyl
215139,Modify the molecule Cc1cc([NH+](C)C[C@H]2C[C@@H]2C)cc(C(=O)[O-])c1N by removing a amine.,Cc1cc([NH+](C)C[C@H]2C[C@@H]2C)cc(C(=O)[O-])c1N,amine
98506,Modify the molecule NC(=O)c1ccc(Oc2cccc(C(=O)[O-])c2)nc1 by removing a benzene_ring.,NC(=O)c1ccc(Oc2cccc(C(=O)[O-])c2)nc1,benzene_ring
207664,Modify the molecule COCC(=O)N1CCC[C@@H](c2nc3c(c(C)[nH+]2)CCCN3Cc2ccc(F)cc2)C1 by removing a halo.,COCC(=O)N1CCC[C@@H](c2nc3c(c(C)[nH+]2)CCCN3Cc2ccc(F)cc2)C1,halo
31059,Remove a halo from the molecule CC[NH+]1CCN([C@@H](C)C[NH2+][C@@H](C)c2nc3cc(Cl)ccc3n2C)CC1.,CC[NH+]1CCN([C@@H](C)C[NH2+][C@@H](C)c2nc3cc(Cl)ccc3n2C)CC1,halo
55440,Please remove a amide from the molecule Cc1ccc(C[NH2+][C@H]2CCC(=O)N(C)C2)cc1.,Cc1ccc(C[NH2+][C@H]2CCC(=O)N(C)C2)cc1,amide
174899,Please remove a amide from the molecule C[C@H](Oc1cccc(Cl)c1)C(=O)N[C@H](C)c1ccc(S(N)(=O)=O)cc1.,C[C@H](Oc1cccc(Cl)c1)C(=O)N[C@H](C)c1ccc(S(N)(=O)=O)cc1,amide
126338,Please remove a benzene_ring from the molecule CCCCC[C@@H](C)NC(=O)NCc1cccc(F)c1.,CCCCC[C@@H](C)NC(=O)NCc1cccc(F)c1,benzene_ring
174660,Please remove a amide from the molecule C[C@@H]1CCCC[C@H]1NC(=O)C1CCN(c2ncnc3c2nc2n3CCCCC2)CC1.,C[C@@H]1CCCC[C@H]1NC(=O)C1CCN(c2ncnc3c2nc2n3CCCCC2)CC1,amide
148843,Modify the molecule CC[C@@H]([NH2+][C@H]1CC(=O)N(CC(F)(F)F)C1)c1cc(C)ccc1OC by removing a amide.,CC[C@@H]([NH2+][C@H]1CC(=O)N(CC(F)(F)F)C1)c1cc(C)ccc1OC,amide
152444,Remove a hydroxyl from the molecule CC1=C(C(=O)Nc2ccccc2)[C@@H](c2ccc(O)c(O)c2)n2ncnc2N1.,CC1=C(C(=O)Nc2ccccc2)[C@@H](c2ccc(O)c(O)c2)n2ncnc2N1,hydroxyl
140246,Modify the molecule O=C(NC1CC1)c1ccccc1NC(=O)C1CCOCC1 by removing a amide.,O=C(NC1CC1)c1ccccc1NC(=O)C1CCOCC1,amide
67874,Modify the molecule Cc1ccsc1C(=O)NNS(=O)(=O)c1c(C)cccc1[N+](=O)[O-] by removing a benzene_ring.,Cc1ccsc1C(=O)NNS(=O)(=O)c1c(C)cccc1[N+](=O)[O-],benzene_ring
170001,Modify the molecule C[C@@]1(C(=O)NCc2ccc(F)cc2)CCCN(C(=O)Nc2ccc(F)c(Cl)c2)C1 by removing a benzene_ring.,C[C@@]1(C(=O)NCc2ccc(F)cc2)CCCN(C(=O)Nc2ccc(F)c(Cl)c2)C1,benzene_ring
42611,Remove a amide from the molecule O=C1[C@@H]2CCC[C@@H]2N1C[NH+]1CCC(c2ccccc2)CC1.,O=C1[C@@H]2CCC[C@@H]2N1C[NH+]1CCC(c2ccccc2)CC1,amide
61487,Modify the molecule O=C(c1ccc2[nH]nnc2c1)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1 by removing a halo.,O=C(c1ccc2[nH]nnc2c1)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1,halo
48001,Please remove a halo from the molecule C[NH+](Cc1ccc(Br)cc1)[C@H]1CCC[C@@H]1S(C)(=O)=O.,C[NH+](Cc1ccc(Br)cc1)[C@H]1CCC[C@@H]1S(C)(=O)=O,halo
156782,Please remove a benzene_ring from the molecule CC(C)C[NH+](C)[C@]1(CN)CCN(Cc2ccccc2)C1.,CC(C)C[NH+](C)[C@]1(CN)CCN(Cc2ccccc2)C1,benzene_ring
145472,Please remove a amide from the molecule Cc1cc(N)cc(C)c1S(=O)(=O)NC[C@@H]1CCC(=O)N1.,Cc1cc(N)cc(C)c1S(=O)(=O)NC[C@@H]1CCC(=O)N1,amide
62541,Modify the molecule COC(=O)c1sc(N2C(=O)C([O-])=C(C(=O)c3ccccc3)[C@@H]2c2ccccc2OC)nc1C by removing a benzene_ring.,COC(=O)c1sc(N2C(=O)C([O-])=C(C(=O)c3ccccc3)[C@@H]2c2ccccc2OC)nc1C,benzene_ring
208563,Please remove a benzene_ring from the molecule C[C@@H]([NH2+]Cc1ccc2c(c1)n(C)c(=O)n2C)c1ccccc1.,C[C@@H]([NH2+]Cc1ccc2c(c1)n(C)c(=O)n2C)c1ccccc1,benzene_ring
53325,Remove a amide from the molecule CC(C)(C)c1noc(CCCC(=O)N[C@@H]2CC[NH+]3CCCC[C@H]23)n1.,CC(C)(C)c1noc(CCCC(=O)N[C@@H]2CC[NH+]3CCCC[C@H]23)n1,amide
23528,Remove a amine from the molecule Cc1cc(C)c2c(=O)cc(CS[C@@H]3NN[C@@H](c4ccco4)[NH+]3C)[nH]c2c1.,Cc1cc(C)c2c(=O)cc(CS[C@@H]3NN[C@@H](c4ccco4)[NH+]3C)[nH]c2c1,amine
122894,Remove a amide from the molecule O=C(NCCn1c(=O)c(=O)[nH]c2ccccc21)[C@H]1CCCN(c2ncccn2)C1.,O=C(NCCn1c(=O)c(=O)[nH]c2ccccc21)[C@H]1CCCN(c2ncccn2)C1,amide
244141,Modify the molecule CC(C)(C)Oc1ccc(O)c([C@H]2CCC[NH2+]2)c1 by removing a benzene_ring.,CC(C)(C)Oc1ccc(O)c([C@H]2CCC[NH2+]2)c1,benzene_ring
144449,Please remove a amide from the molecule Cc1cc(C)n([C@@H](C)C(=O)N2CCc3c([nH+]cn3C3CC3)C2)n1.,Cc1cc(C)n([C@@H](C)C(=O)N2CCc3c([nH+]cn3C3CC3)C2)n1,amide
167379,Remove a halo from the molecule C[C@H]1C[C@@H](C)CN(C(=O)CN2CCN(C(=O)CC(F)(F)F)CC2)C1.,C[C@H]1C[C@@H](C)CN(C(=O)CN2CCN(C(=O)CC(F)(F)F)CC2)C1,halo
35867,Modify the molecule O=C(NCCN1CCN(C(=O)c2cccc([N+](=O)[O-])c2)CC1)c1ccc(F)cc1 by removing a benzene_ring.,O=C(NCCN1CCN(C(=O)c2cccc([N+](=O)[O-])c2)CC1)c1ccc(F)cc1,benzene_ring
137643,Modify the molecule C[C@H](O)CN(C)C(=O)N[C@@H]1C=CCCC1 by removing a hydroxyl.,C[C@H](O)CN(C)C(=O)N[C@@H]1C=CCCC1,hydroxyl
56159,Remove a halo from the molecule C=CCN(CC=C)C(=O)[C@@H](C)NC(=O)c1ccc(Cl)cc1Cl.,C=CCN(CC=C)C(=O)[C@@H](C)NC(=O)c1ccc(Cl)cc1Cl,halo
139797,Modify the molecule C[C@H]1C[C@H](C)CCN1C(=O)C[C@H](O)c1ccc(Cl)cc1 by removing a benzene_ring.,C[C@H]1C[C@H](C)CCN1C(=O)C[C@H](O)c1ccc(Cl)cc1,benzene_ring
198771,Remove a amide from the molecule CCNC(=O)C1CN(C(=O)C(=O)Nc2cccc(C[NH+]3CCCCC3)c2)C1.,CCNC(=O)C1CN(C(=O)C(=O)Nc2cccc(C[NH+]3CCCCC3)c2)C1,amide
151765,Modify the molecule CCn1c([C@@H]2CCC[NH2+]C2)nn(C/C=C/c2ccccc2)c1=O by removing a benzene_ring.,CCn1c([C@@H]2CCC[NH2+]C2)nn(C/C=C/c2ccccc2)c1=O,benzene_ring
88691,Please remove a benzene_ring from the molecule COc1cc(F)cc(CNC(=O)c2sccc2Br)c1.,COc1cc(F)cc(CNC(=O)c2sccc2Br)c1,benzene_ring
132109,Modify the molecule C/C=C/c1cnc(-c2cccnc2)nc1C1CCN(C(=O)[C@H](C)Oc2ccccc2)CC1 by removing a benzene_ring.,C/C=C/c1cnc(-c2cccnc2)nc1C1CCN(C(=O)[C@H](C)Oc2ccccc2)CC1,benzene_ring
3134,Remove a halo from the molecule COc1ccc(F)cc1C(=O)Nc1cc(F)ccc1OCC(F)(F)F.,COc1ccc(F)cc1C(=O)Nc1cc(F)ccc1OCC(F)(F)F,halo
77681,Modify the molecule CCCN1CCN(C(=O)c2ccn(C)n2)C[C@@H](Cc2ccc(-c3ccccc3)cc2)C1=O by removing a amide.,CCCN1CCN(C(=O)c2ccn(C)n2)C[C@@H](Cc2ccc(-c3ccccc3)cc2)C1=O,amide
184622,Remove a amine from the molecule CC(=O)NCc1ccc(S(=O)(=O)N/N=C/c2cccc([N+](=O)[O-])c2)cc1.,CC(=O)NCc1ccc(S(=O)(=O)N/N=C/c2cccc([N+](=O)[O-])c2)cc1,amine
64604,Please remove a nitrile from the molecule CN[C@](C#N)(CSC[C@@H](C)CO)C1CC1.,CN[C@](C#N)(CSC[C@@H](C)CO)C1CC1,nitrile
120959,Please remove a halo from the molecule CCOCC(=O)NNC(=O)c1sc2cccc(F)c2c1COC.,CCOCC(=O)NNC(=O)c1sc2cccc(F)c2c1COC,halo
59252,Modify the molecule Cn1cccc1[C@@H](CNC(=O)NCCc1ccccc1)[NH+]1CCCCCC1 by removing a benzene_ring.,Cn1cccc1[C@@H](CNC(=O)NCCc1ccccc1)[NH+]1CCCCCC1,benzene_ring
96346,Remove a halo from the molecule Cc1cc(CNc2ccc(C(=O)[O-])c(F)c2F)sc1C.,Cc1cc(CNc2ccc(C(=O)[O-])c(F)c2F)sc1C,halo
186660,Please remove a halo from the molecule O=C([C@H]1Cc2ccccc2O1)N(Cc1cccnc1)c1ccc(Cl)cc1.,O=C([C@H]1Cc2ccccc2O1)N(Cc1cccnc1)c1ccc(Cl)cc1,halo
169430,Please remove a amide from the molecule C[C@@H](NC(=O)Cn1nnc(-c2ccsc2)n1)c1ccco1.,C[C@@H](NC(=O)Cn1nnc(-c2ccsc2)n1)c1ccco1,amide
52500,Modify the molecule COC(=O)NCC(=O)Nc1nc(-c2ccc3ccccc3c2)cs1 by removing a amide.,COC(=O)NCC(=O)Nc1nc(-c2ccc3ccccc3c2)cs1,amide
30950,Remove a benzene_ring from the molecule Cc1ccc(-c2csc(NC(=O)CCN3C(=O)[C@@H]4CC[C@](C)(C3=O)C4(C)C)n2)cc1.,Cc1ccc(-c2csc(NC(=O)CCN3C(=O)[C@@H]4CC[C@](C)(C3=O)C4(C)C)n2)cc1,benzene_ring
167719,Remove a benzene_ring from the molecule CCOC(=O)c1ccc(N2C(=O)[C@@H]3CC4=c5ccccc5=[NH+][C@H]4[C@@H](c4cccc(OC)c4)N3C2=O)cc1.,CCOC(=O)c1ccc(N2C(=O)[C@@H]3CC4=c5ccccc5=[NH+][C@H]4[C@@H](c4cccc(OC)c4)N3C2=O)cc1,benzene_ring
56486,Please remove a amide from the molecule O=C(Cn1cnc2nc3c(cc2c1=O)CCCC3)NCCC[NH+]1CCc2ccccc2C1.,O=C(Cn1cnc2nc3c(cc2c1=O)CCCC3)NCCC[NH+]1CCc2ccccc2C1,amide
64276,Modify the molecule CCOC(=O)C[C@@H](NC(=O)c1ccc[n+]([O-])c1)c1ccc(F)cc1 by removing a amide.,CCOC(=O)C[C@@H](NC(=O)c1ccc[n+]([O-])c1)c1ccc(F)cc1,amide
121276,Please remove a benzene_ring from the molecule Cc1n[nH]c(-c2cccc(CNC(=O)[C@H](C)Cc3cccc(Cl)c3)c2)n1.,Cc1n[nH]c(-c2cccc(CNC(=O)[C@H](C)Cc3cccc(Cl)c3)c2)n1,benzene_ring
95607,Please remove a amide from the molecule Cc1ccccc1[C@]1(CC(=O)N(C)[C@H](C)c2nccs2)CC(=O)N(Cc2cccnc2)C1=O.,Cc1ccccc1[C@]1(CC(=O)N(C)[C@H](C)c2nccs2)CC(=O)N(Cc2cccnc2)C1=O,amide
19989,Please remove a benzene_ring from the molecule Cn1cc(S(=O)(=O)[N-]c2c(F)cc(Cl)cc2F)cn1.,Cn1cc(S(=O)(=O)[N-]c2c(F)cc(Cl)cc2F)cn1,benzene_ring
90586,Modify the molecule COc1ccc(-c2ocnc2C(=O)NCCCn2ccnc2)cc1 by removing a benzene_ring.,COc1ccc(-c2ocnc2C(=O)NCCCn2ccnc2)cc1,benzene_ring
238954,Modify the molecule CCOc1ccc(NC(=O)[C@@H](CC(C)C)N2Cc3ccccc3C2=O)cc1 by removing a amide.,CCOc1ccc(NC(=O)[C@@H](CC(C)C)N2Cc3ccccc3C2=O)cc1,amide
222710,Remove a halo from the molecule Cc1nc(Cc2ccc(F)cc2)sc1C(=O)NNC(=O)C[NH+](C)C.,Cc1nc(Cc2ccc(F)cc2)sc1C(=O)NNC(=O)C[NH+](C)C,halo
247765,Please remove a benzene_ring from the molecule CCN(CC)C(=O)Nc1ccc([C@H](C)NC(=O)C2CC=CC2)cc1.,CCN(CC)C(=O)Nc1ccc([C@H](C)NC(=O)C2CC=CC2)cc1,benzene_ring
155198,Modify the molecule CC(=O)N1CCC[C@@H](c2cc(CCO)n(C)n2)C1 by removing a amide.,CC(=O)N1CCC[C@@H](c2cc(CCO)n(C)n2)C1,amide
1992,Remove a halo from the molecule COc1ncnc2c1nc([C@@H](C)Cl)n2[C@H](C)C(N)=O.,COc1ncnc2c1nc([C@@H](C)Cl)n2[C@H](C)C(N)=O,halo
122666,Remove a amide from the molecule CC(=O)N1CCc2cc(NC(=O)c3ccccc3Cc3ccccc3)ccc21.,CC(=O)N1CCc2cc(NC(=O)c3ccccc3Cc3ccccc3)ccc21,amide
140513,Modify the molecule Cc1cccc(NC(=O)c2cnc3n(c2=O)CCS3)c1 by removing a benzene_ring.,Cc1cccc(NC(=O)c2cnc3n(c2=O)CCS3)c1,benzene_ring
159427,Modify the molecule Cc1ccc(C[NH+](C)Cc2c([O-])[nH+]nn2-c2ccccc2)s1 by removing a benzene_ring.,Cc1ccc(C[NH+](C)Cc2c([O-])[nH+]nn2-c2ccccc2)s1,benzene_ring
16702,Modify the molecule Cc1ccc(F)cc1S(=O)(=O)N1CCc2c(c(COCc3ccc(F)cc3Cl)nn2C)C1 by removing a benzene_ring.,Cc1ccc(F)cc1S(=O)(=O)N1CCc2c(c(COCc3ccc(F)cc3Cl)nn2C)C1,benzene_ring
200632,Modify the molecule Cn1c(C[C@H](O)Cc2ccccc2F)nc2ccccc21 by removing a hydroxyl.,Cn1c(C[C@H](O)Cc2ccccc2F)nc2ccccc21,hydroxyl
37496,Modify the molecule Cc1ccc(C(=O)CCC(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)cc1C by removing a amide.,Cc1ccc(C(=O)CCC(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)cc1C,amide
183937,Please remove a halo from the molecule Fc1ccc(C(Br)c2ccc(F)cc2)cc1.,Fc1ccc(C(Br)c2ccc(F)cc2)cc1,halo
54550,Modify the molecule CC[C@@H]1c2ccsc2CCN1C(=O)Cn1ccc(=O)c2sccc21 by removing a amide.,CC[C@@H]1c2ccsc2CCN1C(=O)Cn1ccc(=O)c2sccc21,amide
7447,Modify the molecule O=C(c1cncs1)N1CCC(n2c(CCc3ccccc3)nc3cccnc32)CC1 by removing a benzene_ring.,O=C(c1cncs1)N1CCC(n2c(CCc3ccccc3)nc3cccnc32)CC1,benzene_ring
203908,Please remove a amide from the molecule CCn1c(N2CCC[C@H](C(=O)NCc3ccco3)C2)cc(=O)n(C)c1=O.,CCn1c(N2CCC[C@H](C(=O)NCc3ccco3)C2)cc(=O)n(C)c1=O,amide
90181,Remove a benzene_ring from the molecule Cc1nccn1-c1ccc(CNC(=O)[C@@H]2CNC(=O)N2)cc1F.,Cc1nccn1-c1ccc(CNC(=O)[C@@H]2CNC(=O)N2)cc1F,benzene_ring
33755,Modify the molecule CCc1nc(CC(=O)N(C)Cc2ncnn2C)cs1 by removing a amide.,CCc1nc(CC(=O)N(C)Cc2ncnn2C)cs1,amide
209513,Please remove a nitrile from the molecule N#Cc1ccc(S(=O)(=O)N[C@H](CN2CCOCC2)c2ccccc2)cc1.,N#Cc1ccc(S(=O)(=O)N[C@H](CN2CCOCC2)c2ccccc2)cc1,nitrile
10301,Remove a halo from the molecule O=C(CSc1nc(-c2ccc(Cl)cc2)cs1)Nc1cccc2nsnc12.,O=C(CSc1nc(-c2ccc(Cl)cc2)cs1)Nc1cccc2nsnc12,halo
184009,Modify the molecule CON(C)C(=O)CN1CCN(Cc2csc(-c3ccccc3)n2)CC1 by removing a benzene_ring.,CON(C)C(=O)CN1CCN(Cc2csc(-c3ccccc3)n2)CC1,benzene_ring
8933,Remove a amine from the molecule COCCNC(=O)[C@H](C)OC(=O)c1cc(C)ccc1N.,COCCNC(=O)[C@H](C)OC(=O)c1cc(C)ccc1N,amine
155210,Modify the molecule C[C@H](NC(=O)/C=C/c1ccc(S(=O)(=O)N2CCOCC2)cc1)c1ccc2ccccc2c1 by removing a benzene_ring.,C[C@H](NC(=O)/C=C/c1ccc(S(=O)(=O)N2CCOCC2)cc1)c1ccc2ccccc2c1,benzene_ring
107258,Modify the molecule CC(C)CNS(=O)(=O)c1ccc2c(c1)OCCO2 by removing a amine.,CC(C)CNS(=O)(=O)c1ccc2c(c1)OCCO2,amine
172785,Modify the molecule Cn1c(=O)n(C)c2cc(NC(=O)CCc3nc4ccccc4s3)ccc21 by removing a amide.,Cn1c(=O)n(C)c2cc(NC(=O)CCc3nc4ccccc4s3)ccc21,amide
215961,Please remove a halo from the molecule Cc1ccc(-[n+]2noc([O-])c2C[NH2+]Cc2ccc(F)cc2)cc1.,Cc1ccc(-[n+]2noc([O-])c2C[NH2+]Cc2ccc(F)cc2)cc1,halo
3033,Remove a amide from the molecule COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O.,COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O,amide
28868,Please remove a amide from the molecule O=C(Nc1cccc2ncccc12)c1cc(-c2ccco2)n([C@H]2CCS(=O)(=O)C2)n1.,O=C(Nc1cccc2ncccc12)c1cc(-c2ccco2)n([C@H]2CCS(=O)(=O)C2)n1,amide
209521,Modify the molecule COc1cccc(COc2ccc(Br)cc2)c1 by removing a halo.,COc1cccc(COc2ccc(Br)cc2)c1,halo
249373,Please remove a halo from the molecule Cc1nnc(SCCC(=O)Nc2cccc(F)c2)s1.,Cc1nnc(SCCC(=O)Nc2cccc(F)c2)s1,halo
248038,Please remove a benzene_ring from the molecule N#Cc1cccc(CNC(=O)Nc2ccc3c4c(cccc24)CC3)c1.,N#Cc1cccc(CNC(=O)Nc2ccc3c4c(cccc24)CC3)c1,benzene_ring
78141,Please remove a halo from the molecule O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)NCCc1ccc(Cl)cc1.,O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)NCCc1ccc(Cl)cc1,halo
202113,Modify the molecule C[C@@H](NC(=O)C1CCN(c2ccc(N3CCCC3)nn2)CC1)c1ccccc1 by removing a amide.,C[C@@H](NC(=O)C1CCN(c2ccc(N3CCCC3)nn2)CC1)c1ccccc1,amide
103779,Modify the molecule C[C@@H](CCCCl)[NH2+]CCC(C)(C)C by removing a halo.,C[C@@H](CCCCl)[NH2+]CCC(C)(C)C,halo
18326,Modify the molecule C[C@@H]1CN(C(=O)N[C@@H]2CCS(=O)(=O)C2)C[C@H](c2ccc(F)cc2)O1 by removing a halo.,C[C@@H]1CN(C(=O)N[C@@H]2CCS(=O)(=O)C2)C[C@H](c2ccc(F)cc2)O1,halo
159687,Remove a amide from the molecule CCOC(=O)Nn1c(C)c(C(N)=O)c(C(=O)OC)c1C.,CCOC(=O)Nn1c(C)c(C(N)=O)c(C(=O)OC)c1C,amide
229462,Remove a benzene_ring from the molecule C[C@@H](Cc1nnc(NC(=O)C2CCN(C(=O)[C@H]3CC(=O)N(C(C)(C)C)C3)CC2)s1)c1ccccc1.,C[C@@H](Cc1nnc(NC(=O)C2CCN(C(=O)[C@H]3CC(=O)N(C(C)(C)C)C3)CC2)s1)c1ccccc1,benzene_ring
158042,Please remove a amide from the molecule C[C@H](C(=O)NN)[C@H](C)[NH+](C)C[C@@H]1CCCOC1.,C[C@H](C(=O)NN)[C@H](C)[NH+](C)C[C@@H]1CCCOC1,amide
74227,Please remove a nitrile from the molecule COC(=O)/C(C#N)=C/c1cccc(OC(=O)c2ccc([N+](=O)[O-])cc2Cl)c1.,COC(=O)/C(C#N)=C/c1cccc(OC(=O)c2ccc([N+](=O)[O-])cc2Cl)c1,nitrile
155361,Modify the molecule O=C(/C=C/c1ccc(Cl)cc1)NC[C@H]1CN2CCCC[C@@H]2CO1 by removing a benzene_ring.,O=C(/C=C/c1ccc(Cl)cc1)NC[C@H]1CN2CCCC[C@@H]2CO1,benzene_ring
84990,Please remove a benzene_ring from the molecule CS(=O)(=O)[N-]c1cccc(NC(=O)C2(c3cc(-c4ccccc4)on3)CC2)c1.,CS(=O)(=O)[N-]c1cccc(NC(=O)C2(c3cc(-c4ccccc4)on3)CC2)c1,benzene_ring
195727,Remove a hydroxyl from the molecule COc1ccc(/C(Cl)=N/O)cc1.,COc1ccc(/C(Cl)=N/O)cc1,hydroxyl
175486,Modify the molecule N#C/C(=C/c1cc2c(cc1[N+](=O)[O-])OCO2)S(=O)(=O)c1ccc(Cl)cc1 by removing a halo.,N#C/C(=C/c1cc2c(cc1[N+](=O)[O-])OCO2)S(=O)(=O)c1ccc(Cl)cc1,halo
235946,Remove a amide from the molecule Cc1ccc(S(=O)(=O)N2CCOC23CCN(C(=O)C(=O)NCCC(C)C)CC3)cc1.,Cc1ccc(S(=O)(=O)N2CCOC23CCN(C(=O)C(=O)NCCC(C)C)CC3)cc1,amide
219846,Remove a amide from the molecule C#CCNC(=O)COC(=O)c1sc(NC(=O)c2ccco2)cc1C.,C#CCNC(=O)COC(=O)c1sc(NC(=O)c2ccco2)cc1C,amide
101768,Modify the molecule CCN(CC(C)(C)O)C(=O)CN1CCCCCC1=O by removing a amide.,CCN(CC(C)(C)O)C(=O)CN1CCCCCC1=O,amide
90220,Please remove a amine from the molecule O=S(=O)(Nc1nc2ccc(Br)cc2s1)c1ccc(Cl)s1.,O=S(=O)(Nc1nc2ccc(Br)cc2s1)c1ccc(Cl)s1,amine
24308,Please remove a benzene_ring from the molecule CC[C@](C)([C@@H](NC)c1ccc(F)c(C)c1)[NH+](C)C.,CC[C@](C)([C@@H](NC)c1ccc(F)c(C)c1)[NH+](C)C,benzene_ring
233267,Remove a halo from the molecule COC(=O)c1ccccc1NC(=O)[C@H]1CCCCN1S(=O)(=O)c1ccc(Br)cc1.,COC(=O)c1ccccc1NC(=O)[C@H]1CCCCN1S(=O)(=O)c1ccc(Br)cc1,halo
63678,Remove a amide from the molecule CC(C)NC(=O)c1ccc(NC(=O)c2cnns2)cc1.,CC(C)NC(=O)c1ccc(NC(=O)c2cnns2)cc1,amide
230090,Modify the molecule CCOc1ccc(NC(=O)Nc2ccc(C)s2)cc1 by removing a benzene_ring.,CCOc1ccc(NC(=O)Nc2ccc(C)s2)cc1,benzene_ring
74074,Please remove a benzene_ring from the molecule CCOc1ccc(-c2cc(Cl)ncn2)c(Cl)c1.,CCOc1ccc(-c2cc(Cl)ncn2)c(Cl)c1,benzene_ring
112555,Please remove a amide from the molecule Cc1ccc(Cl)c(OCC(=O)N(C2CCCCC2)[C@H]2CCS(=O)(=O)C2)c1.,Cc1ccc(Cl)c(OCC(=O)N(C2CCCCC2)[C@H]2CCS(=O)(=O)C2)c1,amide
17859,Please remove a benzene_ring from the molecule Fc1ccc(Br)c(C[NH+]2CCCNCC2)c1.,Fc1ccc(Br)c(C[NH+]2CCCNCC2)c1,benzene_ring
231152,Modify the molecule O=C(NC[C@H]1CCC[C@@H](O)C1)NCC1(c2ccccc2)CCC1 by removing a hydroxyl.,O=C(NC[C@H]1CCC[C@@H](O)C1)NCC1(c2ccccc2)CCC1,hydroxyl
6532,Modify the molecule O=C(NCCC1=c2ccccc2=[NH+]C1)c1ccc2c(c1)[C@H](c1ccccc1)ON2 by removing a amine.,O=C(NCCC1=c2ccccc2=[NH+]C1)c1ccc2c(c1)[C@H](c1ccccc1)ON2,amine
156855,Modify the molecule COc1ccc2nc(-n3nc(C)cc3NC(=O)c3ccc([N+](=O)[O-])s3)sc2c1 by removing a nitro.,COc1ccc2nc(-n3nc(C)cc3NC(=O)c3ccc([N+](=O)[O-])s3)sc2c1,nitro
155007,Remove a amine from the molecule CC(C)CCN(C(=O)[C@@H](C)/C(N)=N/O)C1CCCC1.,CC(C)CCN(C(=O)[C@@H](C)/C(N)=N/O)C1CCCC1,amine
203272,Remove a halo from the molecule COc1ccc(CSc2nnc(C3CC3)n2-c2ccccc2)cc1F.,COc1ccc(CSc2nnc(C3CC3)n2-c2ccccc2)cc1F,halo
62394,Modify the molecule CCc1ccc(O)c(C(=O)N2CCOC[C@@H]2C#N)c1 by removing a nitrile.,CCc1ccc(O)c(C(=O)N2CCOC[C@@H]2C#N)c1,nitrile
62296,Please remove a amide from the molecule C#CCNCC(=O)N[C@@H](C)CS(C)(=O)=O.,C#CCNCC(=O)N[C@@H](C)CS(C)(=O)=O,amide
52256,Please remove a benzene_ring from the molecule C[NH+](C)[C@@H](CNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccc1.,C[NH+](C)[C@@H](CNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccc1,benzene_ring
163370,Please remove a amine from the molecule Cc1ccc2oc(=O)n(C[NH+]3CCC[C@H](NS(C)(=O)=O)C3)c2c1.,Cc1ccc2oc(=O)n(C[NH+]3CCC[C@H](NS(C)(=O)=O)C3)c2c1,amine
42076,Remove a benzene_ring from the molecule CCCc1ccc(S(=O)(=O)Nc2cccc(C)c2O)cc1.,CCCc1ccc(S(=O)(=O)Nc2cccc(C)c2O)cc1,benzene_ring
2189,Please remove a amine from the molecule C/[NH+]=C(/NCc1[nH+]ccn1CC(C)C)N1C[C@H]2CC=CC[C@@H]2C1.,C/[NH+]=C(/NCc1[nH+]ccn1CC(C)C)N1C[C@H]2CC=CC[C@@H]2C1,amine
21425,Modify the molecule CCC[C@@H](C)NC(=O)[C@H]1CCCN(C(=O)c2cccc3[nH]ccc23)C1 by removing a amide.,CCC[C@@H](C)NC(=O)[C@H]1CCCN(C(=O)c2cccc3[nH]ccc23)C1,amide
216271,Remove a amide from the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(F)cc2)C1.,Cc1ccc([N+](=O)[O-])cc1NC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(F)cc2)C1,amide
158492,Modify the molecule C[C@H]1[C@@H](C)N(C(=O)NCCc2ccc(N(C)C)cc2)CCS1(=O)=O by removing a benzene_ring.,C[C@H]1[C@@H](C)N(C(=O)NCCc2ccc(N(C)C)cc2)CCS1(=O)=O,benzene_ring
246409,Remove a amide from the molecule CCOC(=O)c1ccc(NC(=O)c2c(C)cccc2C)c(O)c1.,CCOC(=O)c1ccc(NC(=O)c2c(C)cccc2C)c(O)c1,amide
8538,Please remove a benzene_ring from the molecule COCCc1nc(C)c([C@H](C)[NH2+]Cc2ccccc2C)s1.,COCCc1nc(C)c([C@H](C)[NH2+]Cc2ccccc2C)s1,benzene_ring
168291,Modify the molecule Cc1csc(NC(=O)COC(=O)c2ccccc2C(F)(F)F)n1 by removing a amide.,Cc1csc(NC(=O)COC(=O)c2ccccc2C(F)(F)F)n1,amide
34278,Modify the molecule CCCOc1ccc(N2C(=O)C[C@H]([NH2+]Cc3ccc(F)cc3)C2=O)cc1 by removing a benzene_ring.,CCCOc1ccc(N2C(=O)C[C@H]([NH2+]Cc3ccc(F)cc3)C2=O)cc1,benzene_ring
55765,Please remove a halo from the molecule C[C@H]([NH2+][C@H](C)[C@@H](C)C(=O)[O-])c1ccc(F)cc1.,C[C@H]([NH2+][C@H](C)[C@@H](C)C(=O)[O-])c1ccc(F)cc1,halo
220658,Please remove a benzene_ring from the molecule C=C(C)COc1cccc(NC(=O)N2CC[C@@H](COCC)C2)c1.,C=C(C)COc1cccc(NC(=O)N2CC[C@@H](COCC)C2)c1,benzene_ring
150659,Remove a halo from the molecule CC(C)(C)OC(=O)N1CC[C@@H](C[S@@](=O)Cc2ccc(Cl)nc2)C1.,CC(C)(C)OC(=O)N1CC[C@@H](C[S@@](=O)Cc2ccc(Cl)nc2)C1,halo
171551,Modify the molecule COc1cccc(CNC(=O)C[C@H]2CCCCN2S(=O)(=O)c2ccc(F)cc2)c1 by removing a halo.,COc1cccc(CNC(=O)C[C@H]2CCCCN2S(=O)(=O)c2ccc(F)cc2)c1,halo
70671,Modify the molecule CCOC(=O)CCNn1cnnc1 by removing a amine.,CCOC(=O)CCNn1cnnc1,amine
94373,Modify the molecule C[C@H]1C[C@H]1NC(=O)N(C)CCc1ccccc1 by removing a benzene_ring.,C[C@H]1C[C@H]1NC(=O)N(C)CCc1ccccc1,benzene_ring
19379,Please remove a halo from the molecule CC(C)[C@@H]1C[NH+](C(C)C)CCC(=O)N1Cc1ccc(F)cc1.,CC(C)[C@@H]1C[NH+](C(C)C)CCC(=O)N1Cc1ccc(F)cc1,halo
89868,Modify the molecule Cc1ccccc1-c1nnc(CS(=O)(=O)Cc2ccccc2)o1 by removing a benzene_ring.,Cc1ccccc1-c1nnc(CS(=O)(=O)Cc2ccccc2)o1,benzene_ring
157479,Please remove a halo from the molecule C/C(=C\c1cccc(Cl)c1)C(=O)N1CC[C@@H](C)[C@H](O)C1.,C/C(=C\c1cccc(Cl)c1)C(=O)N1CC[C@@H](C)[C@H](O)C1,halo
6410,Please remove a amine from the molecule Cc1cc(S(=O)(=O)NCC[NH+]2CCN(c3ccccc3)CC2)ccc1F.,Cc1cc(S(=O)(=O)NCC[NH+]2CCN(c3ccccc3)CC2)ccc1F,amine
95275,Remove a amide from the molecule CCOC(=O)c1csc(CNC(=O)/C=C/c2ccnc(Cl)c2)n1.,CCOC(=O)c1csc(CNC(=O)/C=C/c2ccnc(Cl)c2)n1,amide
172926,Modify the molecule [NH3+][C@@H](CC12CC3CC(CC(C3)C1)C2)c1ccc(Br)s1 by removing a halo.,[NH3+][C@@H](CC12CC3CC(CC(C3)C1)C2)c1ccc(Br)s1,halo
113648,Remove a amide from the molecule Cn1cccc1C(=O)NNC(=O)c1ccc(Cl)c(Cl)c1.,Cn1cccc1C(=O)NNC(=O)c1ccc(Cl)c(Cl)c1,amide
20534,Remove a halo from the molecule O=C(CCC(=O)N1CCC(c2ccccc2)=N1)Nc1ccc(SC(F)F)cc1.,O=C(CCC(=O)N1CCC(c2ccccc2)=N1)Nc1ccc(SC(F)F)cc1,halo
17453,Please remove a halo from the molecule O=C1NCCN1[C@H]1CCC[NH+](C[C@@H]2CC(c3ccc(Cl)cc3)=NO2)C1.,O=C1NCCN1[C@H]1CCC[NH+](C[C@@H]2CC(c3ccc(Cl)cc3)=NO2)C1,halo
121080,Modify the molecule COC(=O)c1ccc(NC(=O)Cn2cccc(-c3nc(-c4ccc(Cl)cc4)no3)c2=O)cc1 by removing a amide.,COC(=O)c1ccc(NC(=O)Cn2cccc(-c3nc(-c4ccc(Cl)cc4)no3)c2=O)cc1,amide
196158,Remove a nitrile from the molecule CC(C)[C@@H](Oc1ccccc1C#N)C(=O)N1CCN(C[C@H](C)O)CC1.,CC(C)[C@@H](Oc1ccccc1C#N)C(=O)N1CCN(C[C@H](C)O)CC1,nitrile
117927,Please remove a amine from the molecule CC(C)(C)CC(C)(C)NC(=S)N[C@H]1C[C@H]2CC[C@@H]1C2.,CC(C)(C)CC(C)(C)NC(=S)N[C@H]1C[C@H]2CC[C@@H]1C2,amine
52872,Please remove a halo from the molecule COc1ccc(CNC(=O)Cn2cnc3c(c(C)c(C)n3-c3ccc(Cl)cc3)c2=O)cc1.,COc1ccc(CNC(=O)Cn2cnc3c(c(C)c(C)n3-c3ccc(Cl)cc3)c2=O)cc1,halo
157681,Modify the molecule C[C@@H]1OCC[C@H]1C(=O)N[C@@H]1CC(=O)N(CC(F)(F)F)C1 by removing a amide.,C[C@@H]1OCC[C@H]1C(=O)N[C@@H]1CC(=O)N(CC(F)(F)F)C1,amide
174710,Remove a halo from the molecule C[C@H]1C[C@@H](N(C)C(=O)CSCC(F)(F)F)CC[NH+]1C.,C[C@H]1C[C@@H](N(C)C(=O)CSCC(F)(F)F)CC[NH+]1C,halo
21467,Modify the molecule O=C(CN1C(=O)[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C1=O)N1CCN(c2ccccc2Cl)CC1 by removing a benzene_ring.,O=C(CN1C(=O)[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C1=O)N1CCN(c2ccccc2Cl)CC1,benzene_ring
209134,Modify the molecule COCc1ccc(CNC(=O)N[C@@H](CO)c2ccc(Cl)cc2)cc1 by removing a halo.,COCc1ccc(CNC(=O)N[C@@H](CO)c2ccc(Cl)cc2)cc1,halo
91242,Please remove a halo from the molecule Cc1cc(-n2c(C)cn(CN3CCC(O)(C(F)(F)F)CC3)c2=O)no1.,Cc1cc(-n2c(C)cn(CN3CCC(O)(C(F)(F)F)CC3)c2=O)no1,halo
108032,Remove a amine from the molecule CC[C@@H](C)[NH+](CC)[C@@H]1CCc2ccc(OC)cc2[C@@H]1NC.,CC[C@@H](C)[NH+](CC)[C@@H]1CCc2ccc(OC)cc2[C@@H]1NC,amine
130100,Modify the molecule CCCC(=O)NC1CCCCC1 by removing a amide.,CCCC(=O)NC1CCCCC1,amide
171000,Please remove a nitrile from the molecule N#CC1=C(N)C(C#N)(C#N)[C@H](c2ccc(COc3ccc(F)cc3F)o2)[C@@H]2CCCC=C12.,N#CC1=C(N)C(C#N)(C#N)[C@H](c2ccc(COc3ccc(F)cc3F)o2)[C@@H]2CCCC=C12,nitrile
35201,Modify the molecule O=C(N[C@H](Cc1cc(=O)[nH]c(-c2ccccn2)n1)c1ccccc1)C1CCCC1 by removing a benzene_ring.,O=C(N[C@H](Cc1cc(=O)[nH]c(-c2ccccn2)n1)c1ccccc1)C1CCCC1,benzene_ring
210825,Modify the molecule COc1ccccc1[C@@H]1O[C@H](C)Cn2c(-c3ccccc3)c3c(=O)n(C)c(=O)n(C)c3c21 by removing a benzene_ring.,COc1ccccc1[C@@H]1O[C@H](C)Cn2c(-c3ccccc3)c3c(=O)n(C)c(=O)n(C)c3c21,benzene_ring
149935,Modify the molecule COc1ccc([C@H]2[C@@H](C(=O)NCc3ccccn3)c3ccccc3C(=O)N2c2ccc(OC)cc2)cc1 by removing a amide.,COc1ccc([C@H]2[C@@H](C(=O)NCc3ccccn3)c3ccccc3C(=O)N2c2ccc(OC)cc2)cc1,amide
113709,Remove a amide from the molecule CC(C)C[C@@H]1COCCN1C(=O)NNC(=O)Cc1ccccn1.,CC(C)C[C@@H]1COCCN1C(=O)NNC(=O)Cc1ccccn1,amide
55921,Remove a amide from the molecule COC(=O)c1s/c(=N/C(=O)[C@H]2CC(=O)N(CC(C)C)C2)[nH]c1C.,COC(=O)c1s/c(=N/C(=O)[C@H]2CC(=O)N(CC(C)C)C2)[nH]c1C,amide
54500,Modify the molecule Cn1c(C[NH+]2CCCCC2)nc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc21 by removing a halo.,Cn1c(C[NH+]2CCCCC2)nc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc21,halo
162986,Please remove a halo from the molecule COC(=O)c1ccccc1OS(=O)(=O)c1ccc(C)cc1Br.,COC(=O)c1ccccc1OS(=O)(=O)c1ccc(C)cc1Br,halo
62452,Remove a amide from the molecule CNC(=O)NCC(=O)N1[C@@H](C)[C@@H](c2ccccc2)OC[C@H]1C.,CNC(=O)NCC(=O)N1[C@@H](C)[C@@H](c2ccccc2)OC[C@H]1C,amide
106508,Modify the molecule CC1=C(C(N)=O)[C@H](c2ccc(Cl)cc2)n2nc(-c3cccc(Cl)c3)nc2N1 by removing a halo.,CC1=C(C(N)=O)[C@H](c2ccc(Cl)cc2)n2nc(-c3cccc(Cl)c3)nc2N1,halo
78175,Modify the molecule C[NH2+][C@@H]1[C@@H](CN(C)c2ccc(OC)cc2)CCC1(C)C by removing a benzene_ring.,C[NH2+][C@@H]1[C@@H](CN(C)c2ccc(OC)cc2)CCC1(C)C,benzene_ring
38337,Remove a amide from the molecule CN(Cc1ccco1)C(=O)[C@H]1C=C(Cn2cnc3ccccc32)N=N1.,CN(Cc1ccco1)C(=O)[C@H]1C=C(Cn2cnc3ccccc32)N=N1,amide
194564,Modify the molecule CCCCCN(CCO)c1ncnc2ccc(F)cc12 by removing a hydroxyl.,CCCCCN(CCO)c1ncnc2ccc(F)cc12,hydroxyl
37421,Remove a benzene_ring from the molecule CC[C@H](C)c1ccc(OCc2ccc(C(=O)OC)o2)cc1.,CC[C@H](C)c1ccc(OCc2ccc(C(=O)OC)o2)cc1,benzene_ring
154245,Please remove a nitrile from the molecule Cn1ccc(-c2cccc(-c3ccc(C#N)cc3)c2)n1.,Cn1ccc(-c2cccc(-c3ccc(C#N)cc3)c2)n1,nitrile
209256,Please remove a benzene_ring from the molecule COc1ccc(CC[C@H](C)NC(=O)Nc2cccnc2-n2cccn2)cc1.,COc1ccc(CC[C@H](C)NC(=O)Nc2cccnc2-n2cccn2)cc1,benzene_ring
180421,Remove a benzene_ring from the molecule C[NH2+]C[C@]1(c2ccc(OCC(C)C)cc2)CC[C@H]1C.,C[NH2+]C[C@]1(c2ccc(OCC(C)C)cc2)CC[C@H]1C,benzene_ring
18073,Please remove a nitrile from the molecule Cc1nn(-c2ccc(C#N)c(N)c2)c(C)c1Br.,Cc1nn(-c2ccc(C#N)c(N)c2)c(C)c1Br,nitrile
220403,Modify the molecule O=C(N/N=C/c1cccc2ccccc12)c1ccccc1F by removing a amide.,O=C(N/N=C/c1cccc2ccccc12)c1ccccc1F,amide
195922,Please remove a nitro from the molecule CC[NH+](CC)C[C@H](C)Nc1cc(C)c([N+](=O)[O-])cn1.,CC[NH+](CC)C[C@H](C)Nc1cc(C)c([N+](=O)[O-])cn1,nitro
152164,Remove a benzene_ring from the molecule CCc1ccc([C@@H](C)NC(=O)C2CCN(S(C)(=O)=O)CC2)cc1.,CCc1ccc([C@@H](C)NC(=O)C2CCN(S(C)(=O)=O)CC2)cc1,benzene_ring
77808,Please remove a hydroxyl from the molecule CC[C@H](O)Cc1ccc(OC)nc1.,CC[C@H](O)Cc1ccc(OC)nc1,hydroxyl
98838,Modify the molecule C[C@@H](C1CC1)n1c(N)nc2c[nH+]ccc21 by removing a amine.,C[C@@H](C1CC1)n1c(N)nc2c[nH+]ccc21,amine
165329,Remove a amine from the molecule C[C@H](Nc1ccc([NH+]2CCCCC2)cc1)C(=O)Nc1cccc([N+](=O)[O-])c1.,C[C@H](Nc1ccc([NH+]2CCCCC2)cc1)C(=O)Nc1cccc([N+](=O)[O-])c1,amine
145858,Please remove a amine from the molecule Cc1ccc([C@@H]2CCCN2S(=O)(=O)N[C@@H](C)c2nncn2C)o1.,Cc1ccc([C@@H]2CCCN2S(=O)(=O)N[C@@H](C)c2nncn2C)o1,amine
20899,Please remove a halo from the molecule C#Cc1cc(F)c(NC(=O)NCCCN2CCCCCC2=O)c(F)c1.,C#Cc1cc(F)c(NC(=O)NCCCN2CCCCCC2=O)c(F)c1,halo
223990,Modify the molecule O=C(NC[C@](O)(c1ccccc1)C(F)(F)F)c1ccccc1Cl by removing a benzene_ring.,O=C(NC[C@](O)(c1ccccc1)C(F)(F)F)c1ccccc1Cl,benzene_ring
208815,Please remove a halo from the molecule CN(C[C@H](O)C1CC1)c1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-].,CN(C[C@H](O)C1CC1)c1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-],halo
21091,Please remove a benzene_ring from the molecule CC[C@H](C(=O)N1CCC(OCc2ccccc2C)CC1)c1c(C)noc1C.,CC[C@H](C(=O)N1CCC(OCc2ccccc2C)CC1)c1c(C)noc1C,benzene_ring
196393,Please remove a halo from the molecule O=C(Nc1ccc(CN2C(=O)CCC2=O)cc1)c1cnc(Cl)c(Cl)c1.,O=C(Nc1ccc(CN2C(=O)CCC2=O)cc1)c1cnc(Cl)c(Cl)c1,halo
154075,Modify the molecule Cc1ccc(NC(=O)[C@H]2CC(Cl)=CC[C@@H]2C(=O)[O-])cc1[N+](=O)[O-] by removing a halo.,Cc1ccc(NC(=O)[C@H]2CC(Cl)=CC[C@@H]2C(=O)[O-])cc1[N+](=O)[O-],halo
113001,Modify the molecule Cc1cc(F)ccc1N[C@H]1CCCS[C@H]1C by removing a amine.,Cc1cc(F)ccc1N[C@H]1CCCS[C@H]1C,amine
169493,Remove a benzene_ring from the molecule O=C(Nc1ccnc(-c2ccccc2)n1)c1cnn(-c2ccccc2)c1.,O=C(Nc1ccnc(-c2ccccc2)n1)c1cnn(-c2ccccc2)c1,benzene_ring
90688,Please remove a halo from the molecule CCn1c(SCC(=O)Nc2ccc(Cl)cn2)nnc1-c1ccco1.,CCn1c(SCC(=O)Nc2ccc(Cl)cn2)nnc1-c1ccco1,halo
78575,Remove a benzene_ring from the molecule CC(C)[C@H](OC(=O)[C@H]1CCS(=O)(=O)C1)c1cccc(C(F)(F)F)c1.,CC(C)[C@H](OC(=O)[C@H]1CCS(=O)(=O)C1)c1cccc(C(F)(F)F)c1,benzene_ring
110887,Modify the molecule CNC(=O)c1cc(COc2ccc(NC(=O)c3cccc(C)c3)cc2)on1 by removing a benzene_ring.,CNC(=O)c1cc(COc2ccc(NC(=O)c3cccc(C)c3)cc2)on1,benzene_ring
81049,Please remove a halo from the molecule Cc1cccc(C(C)C)c1NC(=O)N(CC[NH+](C)C)Cc1cccc(F)c1.,Cc1cccc(C(C)C)c1NC(=O)N(CC[NH+](C)C)Cc1cccc(F)c1,halo
214979,Remove a benzene_ring from the molecule CCOc1ccc(C(=O)NCc2ccc(Br)cc2F)cc1OCC.,CCOc1ccc(C(=O)NCc2ccc(Br)cc2F)cc1OCC,benzene_ring
104028,Remove a benzene_ring from the molecule C[C@H]1CCCCCN1c1ccc(S(N)(=O)=O)c(N)c1.,C[C@H]1CCCCCN1c1ccc(S(N)(=O)=O)c(N)c1,benzene_ring
232057,Remove a amide from the molecule COCC(=O)NCc1cc2n(n1)CCC[NH+](Cc1ccc3occc3c1)C2.,COCC(=O)NCc1cc2n(n1)CCC[NH+](Cc1ccc3occc3c1)C2,amide
194739,Please remove a benzene_ring from the molecule O=C1[NH+]=c2ccc(C(=O)NCc3cccc(Cl)c3)cc2=[NH+]C1=O.,O=C1[NH+]=c2ccc(C(=O)NCc3cccc(Cl)c3)cc2=[NH+]C1=O,benzene_ring
183028,Please remove a halo from the molecule O=C1NN(c2cccc(Cl)c2)C(=O)/C1=C\c1ccc(-c2ccccc2)o1.,O=C1NN(c2cccc(Cl)c2)C(=O)/C1=C\c1ccc(-c2ccccc2)o1,halo
208635,Modify the molecule CC(C)(C)OC(=O)Nc1ccccc1C(=O)N1CCC[C@@H]1CO by removing a benzene_ring.,CC(C)(C)OC(=O)Nc1ccccc1C(=O)N1CCC[C@@H]1CO,benzene_ring
187224,Remove a benzene_ring from the molecule Cc1cc(Nc2ccccc2C(=O)[O-])nc(Nc2ccccc2C(=O)[O-])n1.,Cc1cc(Nc2ccccc2C(=O)[O-])nc(Nc2ccccc2C(=O)[O-])n1,benzene_ring
120486,Remove a halo from the molecule C[C@H](CCc1ccccc1)NC(=O)Nc1ccc(OC(F)F)c(F)c1.,C[C@H](CCc1ccccc1)NC(=O)Nc1ccc(OC(F)F)c(F)c1,halo
10410,Remove a amide from the molecule O=C(Oc1cccc(N2C(=O)[C@H]3CC=CC[C@@H]3C2=O)c1)c1ccc(Cl)cc1Cl.,O=C(Oc1cccc(N2C(=O)[C@H]3CC=CC[C@@H]3C2=O)c1)c1ccc(Cl)cc1Cl,amide
122183,Remove a amide from the molecule CC(C)c1noc2ncc(C(=O)N3CCc4sccc4[C@H]3c3ccccc3)cc12.,CC(C)c1noc2ncc(C(=O)N3CCc4sccc4[C@H]3c3ccccc3)cc12,amide
193921,Please remove a hydroxyl from the molecule O[C@@H]1CCCC[C@@H]1CC(F)(F)F.,O[C@@H]1CCCC[C@@H]1CC(F)(F)F,hydroxyl
202915,Modify the molecule CC(C)[C@H](C#N)OC(=O)CCOC1CCOCC1 by removing a nitrile.,CC(C)[C@H](C#N)OC(=O)CCOC1CCOCC1,nitrile
202083,Please remove a hydroxyl from the molecule Cc1ccc(NC(=O)N2CCc3ccc(O)cc3C2)s1.,Cc1ccc(NC(=O)N2CCc3ccc(O)cc3C2)s1,hydroxyl
216451,Modify the molecule COc1ccccc1[C@H]1C(C(=O)OC[C@H]2CCCO2)=C(C)NC2=C1C(=O)CCC2 by removing a benzene_ring.,COc1ccccc1[C@H]1C(C(=O)OC[C@H]2CCCO2)=C(C)NC2=C1C(=O)CCC2,benzene_ring
49923,Please remove a amide from the molecule CC(C)n1cc2cc(NC(=O)C(=O)NCC(C)(C)C(N)=O)ccc2n1.,CC(C)n1cc2cc(NC(=O)C(=O)NCC(C)(C)C(N)=O)ccc2n1,amide
121729,Modify the molecule C=C(C)C[NH+]1CCC(NC(=O)c2c(O)cc(Cl)cc2Cl)CC1 by removing a hydroxyl.,C=C(C)C[NH+]1CCC(NC(=O)c2c(O)cc(Cl)cc2Cl)CC1,hydroxyl
159921,Modify the molecule C[NH+]1CCCC[C@H]1c1ncc2c(n1)CCN(C(=O)CCC1CCCC1)C2 by removing a amide.,C[NH+]1CCCC[C@H]1c1ncc2c(n1)CCN(C(=O)CCC1CCCC1)C2,amide
108772,Please remove a halo from the molecule COC(=O)[C@@H]1CCCC[C@@H]1OC(=O)c1ccc(F)c(NC(C)=O)c1.,COC(=O)[C@@H]1CCCC[C@@H]1OC(=O)c1ccc(F)c(NC(C)=O)c1,halo
225275,Modify the molecule Cc1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)Nc3ccc(Cl)cc3)cc2)cc1[N+](=O)[O-] by removing a benzene_ring.,Cc1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)Nc3ccc(Cl)cc3)cc2)cc1[N+](=O)[O-],benzene_ring
10600,Remove a halo from the molecule O=C1CCCC[C@@H]1[C@H]1CCCCN1C(=O)C(F)(F)F.,O=C1CCCC[C@@H]1[C@H]1CCCCN1C(=O)C(F)(F)F,halo
97845,Modify the molecule COC[C@](C)(NC(=O)Nc1cn[nH]c1)c1ccccc1 by removing a benzene_ring.,COC[C@](C)(NC(=O)Nc1cn[nH]c1)c1ccccc1,benzene_ring
218563,Please remove a amide from the molecule COc1cccc2sc(N3CCN(C(=O)[C@@H]4CCCN4S(=O)(=O)c4cccs4)CC3)nc12.,COc1cccc2sc(N3CCN(C(=O)[C@@H]4CCCN4S(=O)(=O)c4cccs4)CC3)nc12,amide
79738,Please remove a hydroxyl from the molecule O/N=C1/CCCN(Cc2ccccc2)C1.,O/N=C1/CCCN(Cc2ccccc2)C1,hydroxyl
244487,Modify the molecule CCN(CCO)C(=O)C[C@@H]1C(=O)NCCN1Cc1c(F)cccc1Cl by removing a hydroxyl.,CCN(CCO)C(=O)C[C@@H]1C(=O)NCCN1Cc1c(F)cccc1Cl,hydroxyl
99634,Modify the molecule CC(=O)Nc1ccc(C)c(NC(=O)N2CCN(c3ccccc3F)CC2)c1 by removing a amide.,CC(=O)Nc1ccc(C)c(NC(=O)N2CCN(c3ccccc3F)CC2)c1,amide
55624,Remove a amide from the molecule CS(=O)(=O)N(Cc1ccc(Cl)cc1)c1ccc(C(=O)Nc2ccccc2C(=O)[O-])cc1.,CS(=O)(=O)N(Cc1ccc(Cl)cc1)c1ccc(C(=O)Nc2ccccc2C(=O)[O-])cc1,amide
233768,Please remove a amide from the molecule COc1cc(NC(=O)c2cc(C)oc2C)cc(OC)c1.,COc1cc(NC(=O)c2cc(C)oc2C)cc(OC)c1,amide
221804,Please remove a hydroxyl from the molecule CC[NH+](CC)CCN1C(N)=[NH+]C[C@@H]1c1cccc(O)c1.,CC[NH+](CC)CCN1C(N)=[NH+]C[C@@H]1c1cccc(O)c1,hydroxyl
240581,Remove a amine from the molecule CNc1ncccc1S(=O)(=O)N1CC[NH+]2CCCC[C@@H]2C1.,CNc1ncccc1S(=O)(=O)N1CC[NH+]2CCCC[C@@H]2C1,amine
5993,Please remove a amine from the molecule Nc1c(C(=O)c2cccs2)sc2nsc(SCC[NH+]3CCCCC3)c12.,Nc1c(C(=O)c2cccs2)sc2nsc(SCC[NH+]3CCCCC3)c12,amine
211177,Modify the molecule CCO[C@H]1C[C@@H]1C(=O)Nc1ccc(Sc2nncs2)c(Cl)c1 by removing a amide.,CCO[C@H]1C[C@@H]1C(=O)Nc1ccc(Sc2nncs2)c(Cl)c1,amide
15978,Please remove a amine from the molecule Cn1c(=O)c2c(nc(N/N=C\C(Br)=C/c3ccccc3)n2Cc2ccccc2)n(C)c1=O.,Cn1c(=O)c2c(nc(N/N=C\C(Br)=C/c3ccccc3)n2Cc2ccccc2)n(C)c1=O,amine
19272,Please remove a amide from the molecule N#Cc1ccccc1OCC(=O)NNC(=O)c1ccc2c(c1)CCCC2.,N#Cc1ccccc1OCC(=O)NNC(=O)c1ccc2c(c1)CCCC2,amide
179635,Please remove a halo from the molecule O=C(CNc1ccc(-c2nnnn2C2CC2)cc1)N1N=C(c2ccc(Cl)cc2)C[C@H]1c1ccco1.,O=C(CNc1ccc(-c2nnnn2C2CC2)cc1)N1N=C(c2ccc(Cl)cc2)C[C@H]1c1ccco1,halo
164070,Remove a amide from the molecule Cc1nc(C)c(C(=O)N2CCC[C@H](NC(=O)c3scnc3C)CC2)o1.,Cc1nc(C)c(C(=O)N2CCC[C@H](NC(=O)c3scnc3C)CC2)o1,amide
214215,Remove a benzene_ring from the molecule N#Cc1cccc(CSc2nnc(C[C@H]3CCS(=O)(=O)C3)o2)c1.,N#Cc1cccc(CSc2nnc(C[C@H]3CCS(=O)(=O)C3)o2)c1,benzene_ring
232789,Modify the molecule CCc1ccc(C(=O)O[C@@H](C)[C@@H]2CCCO2)cc1 by removing a benzene_ring.,CCc1ccc(C(=O)O[C@@H](C)[C@@H]2CCCO2)cc1,benzene_ring
181001,Remove a amide from the molecule COc1ccc(CNC(=O)[C@H](C)N2Cc3ccccc3C2=O)cc1.,COc1ccc(CNC(=O)[C@H](C)N2Cc3ccccc3C2=O)cc1,amide
83674,Remove a halo from the molecule CC(C)=C[C@@H]1[C@@H](C(=O)Nc2cc3c(cc2Cl)NC(=O)CO3)C1(C)C.,CC(C)=C[C@@H]1[C@@H](C(=O)Nc2cc3c(cc2Cl)NC(=O)CO3)C1(C)C,halo
152287,Modify the molecule Cc1cnc([C@@H](C)NC(=O)NCC(=O)NC2CCCCC2)s1 by removing a amide.,Cc1cnc([C@@H](C)NC(=O)NCC(=O)NC2CCCCC2)s1,amide
211766,Modify the molecule Cn1ccc2c(C(=O)N3CCC[C@H](c4nc[nH]n4)C3)cccc21 by removing a amide.,Cn1ccc2c(C(=O)N3CCC[C@H](c4nc[nH]n4)C3)cccc21,amide
167808,Remove a benzene_ring from the molecule COc1cc(CC(=O)Nc2ccc(C)cn2)ccc1C.,COc1cc(CC(=O)Nc2ccc(C)cn2)ccc1C,benzene_ring
79466,Modify the molecule O=C(COc1ccccc1)N1CCC(NS(=O)(=O)c2ccccc2)CC1 by removing a amide.,O=C(COc1ccccc1)N1CCC(NS(=O)(=O)c2ccccc2)CC1,amide
237270,Remove a hydroxyl from the molecule COc1ccc(Br)c(C(=O)N2CCN(CCO)CC2)c1.,COc1ccc(Br)c(C(=O)N2CCN(CCO)CC2)c1,hydroxyl
201053,Remove a amine from the molecule C[C@H](N[C@@H](C)c1nc2c(s1)CCCC2)c1ccc(-n2cncn2)cc1.,C[C@H](N[C@@H](C)c1nc2c(s1)CCCC2)c1ccc(-n2cncn2)cc1,amine
140837,Remove a amide from the molecule CC[C@H](C)[C@@H](NC(=O)[C@@H]1Cc2ccccc2C[NH2+]1)C(=O)NC1CCCCC1.,CC[C@H](C)[C@@H](NC(=O)[C@@H]1Cc2ccccc2C[NH2+]1)C(=O)NC1CCCCC1,amide
176441,Please remove a benzene_ring from the molecule COc1ccccc1[C@H](NC(=O)N[C@H](C)c1ccc(C)o1)c1nccn1C.,COc1ccccc1[C@H](NC(=O)N[C@H](C)c1ccc(C)o1)c1nccn1C,benzene_ring
134932,Please remove a nitro from the molecule O=[N+]([O-])c1c(Nc2cc(Cl)cc(Cl)c2)ncnc1NC1CCCC1.,O=[N+]([O-])c1c(Nc2cc(Cl)cc(Cl)c2)ncnc1NC1CCCC1,nitro
150527,Remove a benzene_ring from the molecule CC(=O)N(c1nc(CSCC(C)C)cs1)c1cccc(C)c1C.,CC(=O)N(c1nc(CSCC(C)C)cs1)c1cccc(C)c1C,benzene_ring
232363,Modify the molecule COc1ccc2c(c1)CCCN2S(=O)(=O)c1ccc(C#N)cc1 by removing a nitrile.,COc1ccc2c(c1)CCCN2S(=O)(=O)c1ccc(C#N)cc1,nitrile
204221,Remove a nitro from the molecule C=C(C)C[NH+](CC)Cc1cc([N+](=O)[O-])cc2c1OCOC2.,C=C(C)C[NH+](CC)Cc1cc([N+](=O)[O-])cc2c1OCOC2,nitro
95196,Modify the molecule C[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC[C@@H]1C(=O)N(C)C by removing a halo.,C[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC[C@@H]1C(=O)N(C)C,halo
65278,Please remove a hydroxyl from the molecule CCC[C@@H](C)C[C@H](O)c1ncc[nH]1.,CCC[C@@H](C)C[C@H](O)c1ncc[nH]1,hydroxyl
3333,Remove a halo from the molecule COc1ccc2c(c1)c(CC(=O)Nc1ccccn1)c(C)n2C(=O)c1ccc(Cl)cc1.,COc1ccc2c(c1)c(CC(=O)Nc1ccccn1)c(C)n2C(=O)c1ccc(Cl)cc1,halo
226506,Remove a amide from the molecule CCCc1nnc(NC(=O)c2cccc(S(C)(=O)=O)c2)s1.,CCCc1nnc(NC(=O)c2cccc(S(C)(=O)=O)c2)s1,amide
100382,Remove a halo from the molecule CC(C)[C@H](C)NC(=O)N[C@H](C)c1ccc(F)c(Cl)c1.,CC(C)[C@H](C)NC(=O)N[C@H](C)c1ccc(F)c(Cl)c1,halo
98069,Please remove a nitrile from the molecule N#CCC[C@H](C#N)CN1CCc2c(cccc2N2CCOC2=O)C1.,N#CCC[C@H](C#N)CN1CCc2c(cccc2N2CCOC2=O)C1,nitrile
162607,Remove a benzene_ring from the molecule Cc1ccccc1NC(=O)c1sc(=S)n(-c2ccccc2F)c1N.,Cc1ccccc1NC(=O)c1sc(=S)n(-c2ccccc2F)c1N,benzene_ring
6118,Modify the molecule CC(C)c1[nH+]ccn1CCN1CCN(C(=O)C(C)(C)Oc2ccc(Cl)cc2)CC1 by removing a halo.,CC(C)c1[nH+]ccn1CCN1CCN(C(=O)C(C)(C)Oc2ccc(Cl)cc2)CC1,halo
187848,Modify the molecule N#Cc1cccnc1NCCNC(=O)c1ccc(F)nc1 by removing a amine.,N#Cc1cccnc1NCCNC(=O)c1ccc(F)nc1,amine
150398,Remove a halo from the molecule Cc1cc(C[NH+](C)CC2CC(Cl)C2)c2ccccc2n1.,Cc1cc(C[NH+](C)CC2CC(Cl)C2)c2ccccc2n1,halo
118870,Remove a benzene_ring from the molecule Cc1ccccc1N(C)CC[C@@H]1CCC[C@]1([NH3+])CO.,Cc1ccccc1N(C)CC[C@@H]1CCC[C@]1([NH3+])CO,benzene_ring
211427,Modify the molecule Cc1nc2ccc(NC(=O)c3cccc(CS(C)(=O)=O)c3)cc2o1 by removing a benzene_ring.,Cc1nc2ccc(NC(=O)c3cccc(CS(C)(=O)=O)c3)cc2o1,benzene_ring
109817,Remove a hydroxyl from the molecule CCOC(=O)CS[C@H]1CC(=O)N(c2ccc(O)cc2C)C1=O.,CCOC(=O)CS[C@H]1CC(=O)N(c2ccc(O)cc2C)C1=O,hydroxyl
64721,Please remove a benzene_ring from the molecule Cc1cc(C)c(OCCCCn2cnc3ccccc3c2=O)c(C)c1.,Cc1cc(C)c(OCCCCn2cnc3ccccc3c2=O)c(C)c1,benzene_ring
9313,Remove a benzene_ring from the molecule COc1ccccc1[C@@H](C)NC(=O)[C@H](C)Sc1cccc2cccnc12.,COc1ccccc1[C@@H](C)NC(=O)[C@H](C)Sc1cccc2cccnc12,benzene_ring
177872,Modify the molecule C[C@H]1CCCCN1C(=O)CN1CC[NH+](CC(=O)Nc2ccccc2SCC#N)CC1 by removing a benzene_ring.,C[C@H]1CCCCN1C(=O)CN1CC[NH+](CC(=O)Nc2ccccc2SCC#N)CC1,benzene_ring
150618,Remove a amine from the molecule O=[N+]([O-])c1c(NCCNS(=O)(=O)c2ccccc2)nc2ccccn12.,O=[N+]([O-])c1c(NCCNS(=O)(=O)c2ccccc2)nc2ccccn12,amine
30735,Please remove a amine from the molecule C[C@H]1NC(C(=O)Nc2cnn(C)c2)=NN(c2ccccc2)C1=O.,C[C@H]1NC(C(=O)Nc2cnn(C)c2)=NN(c2ccccc2)C1=O,amine
19439,Modify the molecule Cn1nccc1CNC(=O)C(=O)Nc1ccc(Oc2ccc(Cl)cc2)nc1 by removing a amide.,Cn1nccc1CNC(=O)C(=O)Nc1ccc(Oc2ccc(Cl)cc2)nc1,amide
191248,Remove a benzene_ring from the molecule COc1ccc(F)c(NC(=O)N[C@@H](C)c2cc(OC)c(OC)cc2C)c1.,COc1ccc(F)c(NC(=O)N[C@@H](C)c2cc(OC)c(OC)cc2C)c1,benzene_ring
245821,Remove a nitrile from the molecule N#CC(C#N)=C(N=C(c1ccccc1)c1ccccc1)C(F)(F)F.,N#CC(C#N)=C(N=C(c1ccccc1)c1ccccc1)C(F)(F)F,nitrile
180364,Remove a nitrile from the molecule CCc1nc(CNc2ccccc2S[C@H](C)CC#N)no1.,CCc1nc(CNc2ccccc2S[C@H](C)CC#N)no1,nitrile
137911,Modify the molecule CCc1ccc(/C([O-])=N/S(=O)(=O)c2ccc(C(C)=O)cc2)cc1 by removing a benzene_ring.,CCc1ccc(/C([O-])=N/S(=O)(=O)c2ccc(C(C)=O)cc2)cc1,benzene_ring
194087,Modify the molecule N#C/C(C(=O)NC1CCCCC1)=C(\[O-])c1cccc(-c2ccoc2)c1 by removing a amide.,N#C/C(C(=O)NC1CCCCC1)=C(\[O-])c1cccc(-c2ccoc2)c1,amide
89950,Remove a halo from the molecule CC1CCC(N(C)C(=O)Nc2cc(N3CCCC3=O)ccc2Cl)CC1.,CC1CCC(N(C)C(=O)Nc2cc(N3CCCC3=O)ccc2Cl)CC1,halo
113007,Remove a hydroxyl from the molecule Cc1ccc2c(=O)n(C3CCC(O)CC3)cnc2c1C.,Cc1ccc2c(=O)n(C3CCC(O)CC3)cnc2c1C,hydroxyl
185970,Remove a amide from the molecule CCOc1cn(-c2ccc(F)cc2)nc1C(=O)N1CCC(Cc2ccccc2)CC1.,CCOc1cn(-c2ccc(F)cc2)nc1C(=O)N1CCC(Cc2ccccc2)CC1,amide
48781,Please remove a benzene_ring from the molecule CCCCNc1ccccc1OC(C)C.,CCCCNc1ccccc1OC(C)C,benzene_ring
224983,Remove a halo from the molecule O=C(c1ccco1)N1CCN(c2ncc(Cl)cc2F)CC1.,O=C(c1ccco1)N1CCN(c2ncc(Cl)cc2F)CC1,halo
108756,Modify the molecule N#Cc1csc(C(=O)NCC(=O)OC2CCCCC2)c1 by removing a amide.,N#Cc1csc(C(=O)NCC(=O)OC2CCCCC2)c1,amide
155449,Please remove a amide from the molecule COc1ccc(NC(=O)c2ccc(Cn3nc(-n4cccc4)c4c(C)cc(C)nc43)cc2)cc1.,COc1ccc(NC(=O)c2ccc(Cn3nc(-n4cccc4)c4c(C)cc(C)nc43)cc2)cc1,amide
68091,Remove a amide from the molecule CCS[C@@H]1CCC[C@@H](NC(=O)[C@@H]2CCC(=O)O2)C1.,CCS[C@@H]1CCC[C@@H](NC(=O)[C@@H]2CCC(=O)O2)C1,amide
15855,Modify the molecule Cc1cccc(NC(=O)C[C@@H]2Nc3cc(C)c(C)cc3NC2=O)c1 by removing a amide.,Cc1cccc(NC(=O)C[C@@H]2Nc3cc(C)c(C)cc3NC2=O)c1,amide
175289,Please remove a benzene_ring from the molecule C=C1C=C([O-])N2C(=NC(NCCC3=c4cc(OC)ccc4=[NH+]C3)=[NH+][C@@H]2c2ccccc2)N1.,C=C1C=C([O-])N2C(=NC(NCCC3=c4cc(OC)ccc4=[NH+]C3)=[NH+][C@@H]2c2ccccc2)N1,benzene_ring
198116,Modify the molecule C/[NH+]=C(/NC[C@H](C)C#N)NC[C@@H]1CCC[NH+](C)C1 by removing a amine.,C/[NH+]=C(/NC[C@H](C)C#N)NC[C@@H]1CCC[NH+](C)C1,amine
180490,Modify the molecule Cc1ccc(C(=O)Nc2nc(CN3C[C@H](C)O[C@@H](C)C3)cs2)cc1C by removing a benzene_ring.,Cc1ccc(C(=O)Nc2nc(CN3C[C@H](C)O[C@@H](C)C3)cs2)cc1C,benzene_ring
42815,Modify the molecule CCOc1cc([C@@H]2C(C#N)=C(N)Oc3[nH]nc(C)c32)ccc1OC(F)F by removing a amine.,CCOc1cc([C@@H]2C(C#N)=C(N)Oc3[nH]nc(C)c32)ccc1OC(F)F,amine
181752,Modify the molecule CC(C)(C)n1cc(C#N)c(NC(=O)C(=O)N2CC[C@H]([N+]3=CCCC3)C2)n1 by removing a amide.,CC(C)(C)n1cc(C#N)c(NC(=O)C(=O)N2CC[C@H]([N+]3=CCCC3)C2)n1,amide
201414,Remove a halo from the molecule COc1ccc(OCC(=O)N2N=C3CCCC[C@@H]3[C@]2(O)C(F)(F)F)cc1.,COc1ccc(OCC(=O)N2N=C3CCCC[C@@H]3[C@]2(O)C(F)(F)F)cc1,halo
104586,Modify the molecule C[C@H]1CCCN(C(=O)C2CCN(S(=O)(=O)c3cccc4nsnc34)CC2)C1 by removing a amide.,C[C@H]1CCCN(C(=O)C2CCN(S(=O)(=O)c3cccc4nsnc34)CC2)C1,amide
134058,Remove a halo from the molecule Fc1ccc2nc(CN3CCC[C@H](c4nncn4C4CC4)C3)oc2c1.,Fc1ccc2nc(CN3CCC[C@H](c4nncn4C4CC4)C3)oc2c1,halo
113187,Modify the molecule CCCn1c(=O)c2ccc(Cl)cc2n2c(SCc3cccc(OC)c3)nnc12 by removing a halo.,CCCn1c(=O)c2ccc(Cl)cc2n2c(SCc3cccc(OC)c3)nnc12,halo
52942,Modify the molecule CC(=O)Nc1ccc(SCC(=O)Nc2cccc(Cl)c2Cl)cc1 by removing a halo.,CC(=O)Nc1ccc(SCC(=O)Nc2cccc(Cl)c2Cl)cc1,halo
106490,Please remove a amine from the molecule CCc1nn(C)cc1NCc1ccccc1OC.,CCc1nn(C)cc1NCc1ccccc1OC,amine
231232,Remove a amide from the molecule COc1ncccc1C(=O)N[C@@H]1CC(=O)N(C2CCCCCC2)C1.,COc1ncccc1C(=O)N[C@@H]1CC(=O)N(C2CCCCCC2)C1,amide
248633,Modify the molecule CC(C)[C@@H]1Nc2ccc(Br)cc2NC1=O by removing a amide.,CC(C)[C@@H]1Nc2ccc(Br)cc2NC1=O,amide
541,Modify the molecule N#Cc1cccc(NC(=O)N2CCC(NC(=O)CC3CCCC3)CC2)c1 by removing a nitrile.,N#Cc1cccc(NC(=O)N2CCC(NC(=O)CC3CCCC3)CC2)c1,nitrile
230546,Remove a benzene_ring from the molecule O=C(OCc1cc(=O)oc2cc(O)c(O)cc12)c1nn(-c2ccccc2)c(=O)c2ccccc12.,O=C(OCc1cc(=O)oc2cc(O)c(O)cc12)c1nn(-c2ccccc2)c(=O)c2ccccc12,benzene_ring
202207,Remove a benzene_ring from the molecule CC[NH2+][C@H]1CC[C@@H](Cc2cccc(O)c2)C1.,CC[NH2+][C@H]1CC[C@@H](Cc2cccc(O)c2)C1,benzene_ring
245849,Modify the molecule Cc1cc2c(cc1C)O[C@@H](C(=O)N1CCC[C@@H](CCC(N)=O)C1)C2 by removing a amide.,Cc1cc2c(cc1C)O[C@@H](C(=O)N1CCC[C@@H](CCC(N)=O)C1)C2,amide
40155,Please remove a amide from the molecule NC(=O)c1ccc(C(=O)Nc2ccc(N3CCSCC3)c(Cl)c2)cc1.,NC(=O)c1ccc(C(=O)Nc2ccc(N3CCSCC3)c(Cl)c2)cc1,amide
93725,Please remove a halo from the molecule Cc1ccccc1CNC(=O)c1nn2ccccc2c1Cl.,Cc1ccccc1CNC(=O)c1nn2ccccc2c1Cl,halo
200110,Please remove a halo from the molecule O=S1(=O)C[C@H]2Sc3nncn3[C@@H]2[C@H]1Br.,O=S1(=O)C[C@H]2Sc3nncn3[C@@H]2[C@H]1Br,halo
99222,Please remove a amide from the molecule Cc1cc(=O)n(CC(=O)N2CCC(c3[nH+]ccn3C)CC2)c2ccccc12.,Cc1cc(=O)n(CC(=O)N2CCC(c3[nH+]ccn3C)CC2)c2ccccc12,amide
117219,Modify the molecule CC(C)[C@H](NC(=O)c1c(F)cccc1F)C(=O)NCC[NH+]1CCc2ccccc2C1 by removing a benzene_ring.,CC(C)[C@H](NC(=O)c1c(F)cccc1F)C(=O)NCC[NH+]1CCc2ccccc2C1,benzene_ring
16908,Please remove a halo from the molecule Cc1cc(C(F)(F)F)nc2nc(NC(=O)c3ccco3)ccc12.,Cc1cc(C(F)(F)F)nc2nc(NC(=O)c3ccco3)ccc12,halo
140775,Please remove a hydroxyl from the molecule Cc1c(C(=O)N2CCCCC[C@H]2C[C@@H](O)c2ccco2)cnn1C.,Cc1c(C(=O)N2CCCCC[C@H]2C[C@@H](O)c2ccco2)cnn1C,hydroxyl
148093,Modify the molecule CC[C@@H](C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCCSCC1 by removing a amide.,CC[C@@H](C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCCSCC1,amide
180926,Modify the molecule CCCCN1C(=O)c2oc3cc(C)cc(C)c3c(=O)c2[C@H]1c1cccc(O)c1 by removing a hydroxyl.,CCCCN1C(=O)c2oc3cc(C)cc(C)c3c(=O)c2[C@H]1c1cccc(O)c1,hydroxyl
18291,Modify the molecule COc1ccc(C2=CC[NH+]([C@H](C)c3nnc(C)o3)CC2)cc1 by removing a benzene_ring.,COc1ccc(C2=CC[NH+]([C@H](C)c3nnc(C)o3)CC2)cc1,benzene_ring
28410,Please remove a amide from the molecule O=C1[C@H]2CC=CC[C@@H]2C(=O)N1CCN1CCCS1(=O)=O.,O=C1[C@H]2CC=CC[C@@H]2C(=O)N1CCN1CCCS1(=O)=O,amide
31590,Remove a amide from the molecule CN1C(=O)N(CC(=O)[O-])C(=O)C12CCCCC2.,CN1C(=O)N(CC(=O)[O-])C(=O)C12CCCCC2,amide
28232,Please remove a halo from the molecule N#Cc1ccc(Oc2ccnc(-c3ccccc3)n2)c(Cl)c1.,N#Cc1ccc(Oc2ccnc(-c3ccccc3)n2)c(Cl)c1,halo
190926,Modify the molecule CCCC(=O)NCC(=O)N1CCCC[C@@H]1Cc1ccccc1 by removing a amide.,CCCC(=O)NCC(=O)N1CCCC[C@@H]1Cc1ccccc1,amide
157048,Please remove a benzene_ring from the molecule Cc1nc(C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)[nH]c1C.,Cc1nc(C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)[nH]c1C,benzene_ring
27580,Please remove a amide from the molecule O=C(c1ccc(=O)n(-c2ccccc2)n1)N1C[C@H]2CCC[C@@H]2C1.,O=C(c1ccc(=O)n(-c2ccccc2)n1)N1C[C@H]2CCC[C@@H]2C1,amide
138224,Remove a benzene_ring from the molecule COc1ccccc1/C=C\C=c1/sc2nc(-c3ccccc3OC(C)=O)nn2c1=O.,COc1ccccc1/C=C\C=c1/sc2nc(-c3ccccc3OC(C)=O)nn2c1=O,benzene_ring
179632,Please remove a benzene_ring from the molecule Cc1ccoc1C(=O)OCCCn1nnc(-c2ccccc2)n1.,Cc1ccoc1C(=O)OCCCn1nnc(-c2ccccc2)n1,benzene_ring
139752,Modify the molecule O=C1CNC(=O)N1CCCn1nnc(-c2ccc(Br)cc2)n1 by removing a benzene_ring.,O=C1CNC(=O)N1CCCn1nnc(-c2ccc(Br)cc2)n1,benzene_ring
196207,Remove a halo from the molecule COCCCNC(=O)c1cccc2c1N[C@H](c1ccccc1Cl)[C@H]1CC=C[C@@H]21.,COCCCNC(=O)c1cccc2c1N[C@H](c1ccccc1Cl)[C@H]1CC=C[C@@H]21,halo
199404,Remove a amide from the molecule O=C(CCCc1ccccc1)Nc1c(C(=O)Nc2ccc3c(c2)OCCO3)oc2ccccc12.,O=C(CCCc1ccccc1)Nc1c(C(=O)Nc2ccc3c(c2)OCCO3)oc2ccccc12,amide
64628,Modify the molecule C=CCCCN(C)c1cc[nH+]c(CN2CCN(C(C)=O)CC2)c1 by removing a amide.,C=CCCCN(C)c1cc[nH+]c(CN2CCN(C(C)=O)CC2)c1,amide
46410,Modify the molecule CC(=O)c1cccc(OCC(=O)NC2CCOCC2)c1 by removing a amide.,CC(=O)c1cccc(OCC(=O)NC2CCOCC2)c1,amide
219843,Please remove a amine from the molecule Cc1nn(C)c(C)c1NC(=S)NCc1cccnc1.,Cc1nn(C)c(C)c1NC(=S)NCc1cccnc1,amine
205563,Remove a halo from the molecule C=CCC[C@H](C)OC(=O)c1cc(NC(C)=O)ccc1F.,C=CCC[C@H](C)OC(=O)c1cc(NC(C)=O)ccc1F,halo
92510,Modify the molecule COc1ccc(N2CCOCC2)c(NC(=O)c2cc(OC)c(OC)c(OC)c2)c1 by removing a amide.,COc1ccc(N2CCOCC2)c(NC(=O)c2cc(OC)c(OC)c(OC)c2)c1,amide
101051,Please remove a amide from the molecule C[C@@H]([NH2+]C1CCN(C(=O)[C@@H]2COc3ccccc3O2)CC1)c1ccccn1.,C[C@@H]([NH2+]C1CCN(C(=O)[C@@H]2COc3ccccc3O2)CC1)c1ccccn1,amide
10938,Please remove a nitro from the molecule CC[C@@H]1CCc2nc(NC(=O)c3ccc([N+](=O)[O-])o3)sc2C1.,CC[C@@H]1CCc2nc(NC(=O)c3ccc([N+](=O)[O-])o3)sc2C1,nitro
69034,Remove a halo from the molecule COc1cc(C[NH+](C)CC(=O)N[C@H]2CCS(=O)(=O)C2)ccc1F.,COc1cc(C[NH+](C)CC(=O)N[C@H]2CCS(=O)(=O)C2)ccc1F,halo
158024,Modify the molecule C[C@H]1CN(C(=O)CCc2cscn2)[C@H](C)CN1C(=O)OC(C)(C)C by removing a amide.,C[C@H]1CN(C(=O)CCc2cscn2)[C@H](C)CN1C(=O)OC(C)(C)C,amide
166044,Modify the molecule CCc1ccccc1NC(=O)CCN1C[C@H](C(=O)[O-])CC1=O by removing a benzene_ring.,CCc1ccccc1NC(=O)CCN1C[C@H](C(=O)[O-])CC1=O,benzene_ring
15270,Remove a amide from the molecule CSc1ccc(CCNC(=O)c2cc(=O)nc3sc(N4CCCCCC4)nn23)cc1.,CSc1ccc(CCNC(=O)c2cc(=O)nc3sc(N4CCCCCC4)nn23)cc1,amide
42027,Remove a amine from the molecule CNC(SCc1cc2c(cc1Cl)OCO2)=C(C(C)=O)C(C)=O.,CNC(SCc1cc2c(cc1Cl)OCO2)=C(C(C)=O)C(C)=O,amine
215948,Remove a nitrile from the molecule C[C@H]1CCCC[C@H]1NC(=O)N1CCC[NH+](Cc2ccc(C#N)cc2)CC1.,C[C@H]1CCCC[C@H]1NC(=O)N1CCC[NH+](Cc2ccc(C#N)cc2)CC1,nitrile
48070,Remove a amide from the molecule CCOc1c(Cl)cc(C[NH+]2CCC(N3CCCCC3=O)CC2)cc1OC.,CCOc1c(Cl)cc(C[NH+]2CCC(N3CCCCC3=O)CC2)cc1OC,amide
188329,Please remove a benzene_ring from the molecule CCOc1ccc(F)c(C(=O)N[C@H]2C[C@](C)(OC)C2(C)C)c1F.,CCOc1ccc(F)c(C(=O)N[C@H]2C[C@](C)(OC)C2(C)C)c1F,benzene_ring
246917,Remove a benzene_ring from the molecule CCN(Cc1cnn(C)c1)S(=O)(=O)c1cccc(C(F)(F)F)c1.,CCN(Cc1cnn(C)c1)S(=O)(=O)c1cccc(C(F)(F)F)c1,benzene_ring
181113,Remove a amide from the molecule Cc1ccccc1-n1nnnc1SCC(=O)Nc1ccccc1C(=O)NC1CCCC1.,Cc1ccccc1-n1nnnc1SCC(=O)Nc1ccccc1C(=O)NC1CCCC1,amide
45650,Please remove a halo from the molecule CCc1nnc2sc(-c3ccc(OC)c(NC(=O)c4cc(Cl)c(OC)c(Cl)c4)c3)nn12.,CCc1nnc2sc(-c3ccc(OC)c(NC(=O)c4cc(Cl)c(OC)c(Cl)c4)c3)nn12,halo
200495,Please remove a benzene_ring from the molecule CC[C@H](CSC)N(C)C(=O)[C@@H]1CN(Cc2ccccc2)CCO1.,CC[C@H](CSC)N(C)C(=O)[C@@H]1CN(Cc2ccccc2)CCO1,benzene_ring
170673,Remove a benzene_ring from the molecule COc1ccc(-c2cc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)ccn3n2)cc1OC.,COc1ccc(-c2cc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)ccn3n2)cc1OC,benzene_ring
203367,Modify the molecule Nc1ccc(NC(=O)C(F)(F)F)c(Cl)c1 by removing a amide.,Nc1ccc(NC(=O)C(F)(F)F)c(Cl)c1,amide
108041,Please remove a halo from the molecule COC(=O)CNC(=O)c1cnn(-c2ccc(Cl)cc2)c1-n1cccc1.,COC(=O)CNC(=O)c1cnn(-c2ccc(Cl)cc2)c1-n1cccc1,halo
196929,Remove a benzene_ring from the molecule COCCO[C@@H](C)C(=O)Nc1cc(F)c(F)cc1F.,COCCO[C@@H](C)C(=O)Nc1cc(F)c(F)cc1F,benzene_ring
128241,Please remove a amide from the molecule CC1(C)CCN(C(=O)[C@@H]([NH3+])CC(=O)[O-])C1.,CC1(C)CCN(C(=O)[C@@H]([NH3+])CC(=O)[O-])C1,amide
39225,Please remove a amide from the molecule Cc1nn(C)c2ncc(NC(=O)COc3ccc4ccccc4c3)cc12.,Cc1nn(C)c2ncc(NC(=O)COc3ccc4ccccc4c3)cc12,amide
102452,Remove a benzene_ring from the molecule O=C(NCCC(=O)N1CCCC1)Nc1ccn(Cc2ccccc2)n1.,O=C(NCCC(=O)N1CCCC1)Nc1ccn(Cc2ccccc2)n1,benzene_ring
75837,Modify the molecule O=C(c1cccnc1SC1CCCC1)N1CCC([C@H](O)c2ccccc2)CC1 by removing a amide.,O=C(c1cccnc1SC1CCCC1)N1CCC([C@H](O)c2ccccc2)CC1,amide
179957,Remove a benzene_ring from the molecule CC(C)(CNC(=O)NCc1cccc(Cn2cncn2)c1)c1ccncc1.,CC(C)(CNC(=O)NCc1cccc(Cn2cncn2)c1)c1ccncc1,benzene_ring
193543,Modify the molecule C=CCn1c(C)nnc1S[C@@H](C(=O)Nc1cccc(F)c1)C(C)C by removing a halo.,C=CCn1c(C)nnc1S[C@@H](C(=O)Nc1cccc(F)c1)C(C)C,halo
152672,Remove a halo from the molecule CC1(C)COC(=O)[C@@H](Br)C1.,CC1(C)COC(=O)[C@@H](Br)C1,halo
36799,Modify the molecule Cn1nccc1CNC(=O)c1cccc(C#N)c1 by removing a benzene_ring.,Cn1nccc1CNC(=O)c1cccc(C#N)c1,benzene_ring
15117,Modify the molecule CCCOc1cc(C)ccc1NC(=O)N1CCCC[C@@H]1CN1CCCC1=O by removing a benzene_ring.,CCCOc1cc(C)ccc1NC(=O)N1CCCC[C@@H]1CN1CCCC1=O,benzene_ring
20909,Please remove a hydroxyl from the molecule CS[C@@H](CO)[C@H](C)NC(=O)c1cn(C)nc1-c1ccccc1.,CS[C@@H](CO)[C@H](C)NC(=O)c1cn(C)nc1-c1ccccc1,hydroxyl
42793,Please remove a amide from the molecule C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)C1.,C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)C1,amide
232342,Modify the molecule Cc1nc(=O)[nH]c(C)c1CC(=O)Nc1sccc1C(=O)[O-] by removing a amide.,Cc1nc(=O)[nH]c(C)c1CC(=O)Nc1sccc1C(=O)[O-],amide
193267,Please remove a hydroxyl from the molecule Cn1cc(C(=O)NC[C@@]2(O)CCCc3ccccc32)c(-c2ccccc2)n1.,Cn1cc(C(=O)NC[C@@]2(O)CCCc3ccccc32)c(-c2ccccc2)n1,hydroxyl
207000,Please remove a halo from the molecule CC(C)(C)OC(=O)N1CC[NH+](Cc2ccc(Cl)nc2)[C@H](C(=O)[O-])C1.,CC(C)(C)OC(=O)N1CC[NH+](Cc2ccc(Cl)nc2)[C@H](C(=O)[O-])C1,halo
162417,Modify the molecule C[NH2+][C@H](C)c1cnc(-c2cncc(Br)c2)nc1C by removing a halo.,C[NH2+][C@H](C)c1cnc(-c2cncc(Br)c2)nc1C,halo
19613,Please remove a benzene_ring from the molecule C[C@@H]1CCc2cc(F)ccc2N1S(=O)(=O)CCOc1ccc(F)cc1.,C[C@@H]1CCc2cc(F)ccc2N1S(=O)(=O)CCOc1ccc(F)cc1,benzene_ring
195832,Please remove a amine from the molecule C#CCN/C(NCC(C)(C)[NH+]1CCCCC1)=[NH+]/CC.,C#CCN/C(NCC(C)(C)[NH+]1CCCCC1)=[NH+]/CC,amine
238455,Modify the molecule Cc1ccn2c(=O)c(C(=O)N3CCOC[C@@H]3C3CC3)cnc2c1 by removing a amide.,Cc1ccn2c(=O)c(C(=O)N3CCOC[C@@H]3C3CC3)cnc2c1,amide
51754,Remove a halo from the molecule O=C(NCc1c(O)ccc2c1CCCC2)N[C@@H]1CCN(CC(F)(F)F)C1.,O=C(NCc1c(O)ccc2c1CCCC2)N[C@@H]1CCN(CC(F)(F)F)C1,halo
139638,Please remove a benzene_ring from the molecule CC(C)(C)c1ccc(-c2csc(NC(=O)c3ccccc3OCC(N)=O)n2)cc1.,CC(C)(C)c1ccc(-c2csc(NC(=O)c3ccccc3OCC(N)=O)n2)cc1,benzene_ring
222716,Please remove a nitro from the molecule N#C[C@@H]1COCCN1Cc1cc(O)ccc1[N+](=O)[O-].,N#C[C@@H]1COCCN1Cc1cc(O)ccc1[N+](=O)[O-],nitro
160782,Remove a benzene_ring from the molecule CN(CC(=O)NCC[NH+](C)C)S(=O)(=O)c1cc(Cl)ccc1Cl.,CN(CC(=O)NCC[NH+](C)C)S(=O)(=O)c1cc(Cl)ccc1Cl,benzene_ring
191903,Modify the molecule O=C(Cc1ccc(F)cc1)N1CCS[C@@H]1c1cccc(F)c1 by removing a benzene_ring.,O=C(Cc1ccc(F)cc1)N1CCS[C@@H]1c1cccc(F)c1,benzene_ring
212213,Please remove a amide from the molecule Cc1cc(C(=O)NCc2ccc(NC(=O)C3CC3)cc2)cc(S(N)(=O)=O)c1C.,Cc1cc(C(=O)NCc2ccc(NC(=O)C3CC3)cc2)cc(S(N)(=O)=O)c1C,amide
215283,Please remove a amine from the molecule C[C@H]1C[C@H](Nc2ncccc2C#N)C(=O)N1c1ccccc1.,C[C@H]1C[C@H](Nc2ncccc2C#N)C(=O)N1c1ccccc1,amine
180890,Modify the molecule CC[NH+](Cc1ccc(-c2ccccc2OC)cc1)CC(C)(C)O by removing a hydroxyl.,CC[NH+](Cc1ccc(-c2ccccc2OC)cc1)CC(C)(C)O,hydroxyl
181552,Modify the molecule C[C@H]([NH2+]Cc1ccc(C(N)=O)o1)c1cc(Br)ccc1F by removing a amide.,C[C@H]([NH2+]Cc1ccc(C(N)=O)o1)c1cc(Br)ccc1F,amide
165127,Please remove a benzene_ring from the molecule CCOc1ccc(N(Cc2cc3cc(C)ccc3[nH]c2=O)C(=O)c2ccc([N+](=O)[O-])cc2)cc1.,CCOc1ccc(N(Cc2cc3cc(C)ccc3[nH]c2=O)C(=O)c2ccc([N+](=O)[O-])cc2)cc1,benzene_ring
185805,Please remove a benzene_ring from the molecule Nc1c(Nc2nc3ccccc3s2)ncnc1Nc1ccccc1F.,Nc1c(Nc2nc3ccccc3s2)ncnc1Nc1ccccc1F,benzene_ring
211725,Modify the molecule CCN1CCN(C(=O)[C@@H](C)n2c3ccccc3c3cnn(C)c(=O)c32)CC1 by removing a amide.,CCN1CCN(C(=O)[C@@H](C)n2c3ccccc3c3cnn(C)c(=O)c32)CC1,amide
101456,Please remove a amine from the molecule CC[C@@H](C)N[C@@H]1CCCC[C@@H]1[NH3+].,CC[C@@H](C)N[C@@H]1CCCC[C@@H]1[NH3+],amine
199955,Please remove a benzene_ring from the molecule Cc1cccc([C@@H]([C@H](C)[NH3+])N(C)C[C@@H]2CCC[NH+]2C)c1.,Cc1cccc([C@@H]([C@H](C)[NH3+])N(C)C[C@@H]2CCC[NH+]2C)c1,benzene_ring
129516,Modify the molecule CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCCN(c2ccccc2)C1 by removing a amide.,CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCCN(c2ccccc2)C1,amide
145588,Modify the molecule CN(C)c1ccc(CN(C(=O)c2sc3ccccc3c2Cl)[C@H]2CCS(=O)(=O)C2)cc1 by removing a halo.,CN(C)c1ccc(CN(C(=O)c2sc3ccccc3c2Cl)[C@H]2CCS(=O)(=O)C2)cc1,halo
109196,Modify the molecule CSc1nc([O-])c(C(=O)N[C@@H](C)c2ccccc2C)cc1C#N by removing a benzene_ring.,CSc1nc([O-])c(C(=O)N[C@@H](C)c2ccccc2C)cc1C#N,benzene_ring
211935,Modify the molecule CCc1nnc(NC(=O)c2noc3c2COc2ccc(C)cc2-3)s1 by removing a amide.,CCc1nnc(NC(=O)c2noc3c2COc2ccc(C)cc2-3)s1,amide
37820,Please remove a benzene_ring from the molecule Cc1ccc(-n2nc(C(=O)[O-])c3c2CCC3)c(F)c1.,Cc1ccc(-n2nc(C(=O)[O-])c3c2CCC3)c(F)c1,benzene_ring
220147,Remove a amide from the molecule Cn1nc(C(=O)Nc2ccccc2C(C)(C)C)ccc1=O.,Cn1nc(C(=O)Nc2ccccc2C(C)(C)C)ccc1=O,amide
106260,Please remove a benzene_ring from the molecule Cc1cc(C)cc(OC(=O)[C@H](C)S(=O)(=O)c2ccc(F)cc2)c1.,Cc1cc(C)cc(OC(=O)[C@H](C)S(=O)(=O)c2ccc(F)cc2)c1,benzene_ring
67238,Modify the molecule CCC(CC)N1C(=O)C2(CCCC2)NC(=O)C1(C)C by removing a amide.,CCC(CC)N1C(=O)C2(CCCC2)NC(=O)C1(C)C,amide
203208,Modify the molecule CC(C)[C@@H]1Nc2ccc(C(=O)NCc3ccccc3Cl)cc2NC1=O by removing a halo.,CC(C)[C@@H]1Nc2ccc(C(=O)NCc3ccccc3Cl)cc2NC1=O,halo
114012,Remove a benzene_ring from the molecule O=[N+]([O-])c1ccc(CN2CCN(CCn3cc[nH+]c3)CC2)cc1.,O=[N+]([O-])c1ccc(CN2CCN(CCn3cc[nH+]c3)CC2)cc1,benzene_ring
968,Please remove a halo from the molecule CCc1nn(CC)c(C[C@@]2(C3CC3)CCC[NH2+]2)c1Br.,CCc1nn(CC)c(C[C@@]2(C3CC3)CCC[NH2+]2)c1Br,halo
137518,Remove a amide from the molecule CCOc1cc2c(cc1/C=C/C(=O)NCC(C)(C)[NH+](C)C)O[C@@H](C)C2.,CCOc1cc2c(cc1/C=C/C(=O)NCC(C)(C)[NH+](C)C)O[C@@H](C)C2,amide
152538,Please remove a amide from the molecule C[NH2+]C[C@@H](C)C(=O)NCCNC(C)=O.,C[NH2+]C[C@@H](C)C(=O)NCCNC(C)=O,amide
84563,Modify the molecule COc1ccccc1N1C[C@H](C(=O)Nc2ccc(O)cc2)CC1=O by removing a amide.,COc1ccccc1N1C[C@H](C(=O)Nc2ccc(O)cc2)CC1=O,amide
226174,Please remove a halo from the molecule COCC(=O)N/N=C/c1cc(Br)ccc1O.,COCC(=O)N/N=C/c1cc(Br)ccc1O,halo
190493,Modify the molecule CCOC(=O)Nc1ccc(NC(=O)c2ccc3[nH]c4c(c3c2)CCCC4)cc1 by removing a benzene_ring.,CCOC(=O)Nc1ccc(NC(=O)c2ccc3[nH]c4c(c3c2)CCCC4)cc1,benzene_ring
6861,Remove a hydroxyl from the molecule COc1ccc(C[C@H](O)Cc2ccn(C(C)C)n2)cn1.,COc1ccc(C[C@H](O)Cc2ccn(C(C)C)n2)cn1,hydroxyl
217994,Please remove a benzene_ring from the molecule CSCCOC(=O)C1CCN(C(=O)c2ccc(F)cc2F)CC1.,CSCCOC(=O)C1CCN(C(=O)c2ccc(F)cc2F)CC1,benzene_ring
185737,Modify the molecule CCCCCNC(=O)c1cc2c([nH]c1=O)CC[C@H](C)C2 by removing a amide.,CCCCCNC(=O)c1cc2c([nH]c1=O)CC[C@H](C)C2,amide
83366,Remove a halo from the molecule C[C@H]([NH2+]CC1(CS(C)(=O)=O)CC1)c1ccc(N2CCCCC2)c(F)c1.,C[C@H]([NH2+]CC1(CS(C)(=O)=O)CC1)c1ccc(N2CCCCC2)c(F)c1,halo
135144,Remove a amide from the molecule COCCN1C(=O)c2oc3cc(C)c(C)cc3c(=O)c2[C@@H]1c1ccc(OCC(N)=O)cc1.,COCCN1C(=O)c2oc3cc(C)c(C)cc3c(=O)c2[C@@H]1c1ccc(OCC(N)=O)cc1,amide
232156,Modify the molecule C[C@@H](OC(=O)c1cccc(S(=O)(=O)N2CCc3ccccc3C2)c1)C(=O)c1ccccc1 by removing a benzene_ring.,C[C@@H](OC(=O)c1cccc(S(=O)(=O)N2CCc3ccccc3C2)c1)C(=O)c1ccccc1,benzene_ring
237902,Remove a amide from the molecule CC[C@H](C)N(C)C(=O)[C@H]1CCC[NH2+][C@@H]1C.,CC[C@H](C)N(C)C(=O)[C@H]1CCC[NH2+][C@@H]1C,amide
85217,Please remove a amide from the molecule COc1ccc([C@@H]2c3c(oc4ccc(C)cc4c3=O)C(=O)N2Cc2ccc(C)cc2)cc1OC.,COc1ccc([C@@H]2c3c(oc4ccc(C)cc4c3=O)C(=O)N2Cc2ccc(C)cc2)cc1OC,amide
47792,Remove a benzene_ring from the molecule CN(Cc1ccc(F)c(F)c1)C[C@H](O)c1ccccc1Cl.,CN(Cc1ccc(F)c(F)c1)C[C@H](O)c1ccccc1Cl,benzene_ring
190209,Modify the molecule Cc1noc(C)c1C[NH+](C)Cc1c(O)ccc2ccccc12 by removing a hydroxyl.,Cc1noc(C)c1C[NH+](C)Cc1c(O)ccc2ccccc12,hydroxyl
129256,Modify the molecule O=C(CCCNC(=O)[C@@H]1COc2ccccc2O1)Nc1nc2ccccc2s1 by removing a amide.,O=C(CCCNC(=O)[C@@H]1COc2ccccc2O1)Nc1nc2ccccc2s1,amide
232539,Please remove a benzene_ring from the molecule OC[C@H](Nc1cccc(Br)c1)c1cccc(C2CC2)c1.,OC[C@H](Nc1cccc(Br)c1)c1cccc(C2CC2)c1,benzene_ring
74504,Remove a halo from the molecule CCn1c(=O)c(N2CCC(C(=O)Nc3cccc(Cl)c3)CC2)c(C)n(-c2ccccc2)c1=O.,CCn1c(=O)c(N2CCC(C(=O)Nc3cccc(Cl)c3)CC2)c(C)n(-c2ccccc2)c1=O,halo
240977,Modify the molecule COCc1cc(C(=O)NCC(=O)N2CCc3ccccc3C2)no1 by removing a amide.,COCc1cc(C(=O)NCC(=O)N2CCc3ccccc3C2)no1,amide
193256,Remove a benzene_ring from the molecule CC(C)(C)c1ccc(NC(=O)/C=C/c2ccc(S(C)(=O)=O)cc2)cc1.,CC(C)(C)c1ccc(NC(=O)/C=C/c2ccc(S(C)(=O)=O)cc2)cc1,benzene_ring
171420,Remove a amide from the molecule C[C@@H](NC(=O)C(C)(C)C)c1nc2ccccc2n1CC(=O)N(C)c1ccccc1.,C[C@@H](NC(=O)C(C)(C)C)c1nc2ccccc2n1CC(=O)N(C)c1ccccc1,amide
56137,Remove a hydroxyl from the molecule CC[C@H]1CC[C@H]([C@H](O)Cc2cccc(O)c2)C1.,CC[C@H]1CC[C@H]([C@H](O)Cc2cccc(O)c2)C1,hydroxyl
30536,Remove a amide from the molecule O=C1CSc2ccc(NC(=O)c3cccc4cn[nH]c34)cc2N1.,O=C1CSc2ccc(NC(=O)c3cccc4cn[nH]c34)cc2N1,amide
144929,Modify the molecule N#C[C@@]1([C@@H](O)c2ccc3c(c2)OCCO3)CCOC1 by removing a nitrile.,N#C[C@@]1([C@@H](O)c2ccc3c(c2)OCCO3)CCOC1,nitrile
182837,Remove a benzene_ring from the molecule Cc1ccc(-c2nc(C)sc2CC(=O)Nc2ccccc2)cc1.,Cc1ccc(-c2nc(C)sc2CC(=O)Nc2ccccc2)cc1,benzene_ring
181972,Modify the molecule CCS(=O)(=O)CCn1ccc(NC(=O)c2ccccc2C)n1 by removing a amide.,CCS(=O)(=O)CCn1ccc(NC(=O)c2ccccc2C)n1,amide
123394,Modify the molecule O=C1N[C@@]2(CCc3ccccc32)C(=O)N1Cc1nnc(-c2ccco2)o1 by removing a amide.,O=C1N[C@@]2(CCc3ccccc32)C(=O)N1Cc1nnc(-c2ccco2)o1,amide
65181,Please remove a amide from the molecule CN(Cc1ccco1)C(=O)Cn1cnc2sc(-c3ccccc3)cc2c1=O.,CN(Cc1ccco1)C(=O)Cn1cnc2sc(-c3ccccc3)cc2c1=O,amide
68552,Remove a benzene_ring from the molecule CCOC(=O)[C@H]1C(=O)N=C(N2CC[NH+](CC)CC2)[N-][C@H]1c1cccc(Cl)c1.,CCOC(=O)[C@H]1C(=O)N=C(N2CC[NH+](CC)CC2)[N-][C@H]1c1cccc(Cl)c1,benzene_ring
40465,Remove a amide from the molecule C[C@H](C[NH+]1CCCCC1)NC(=O)c1cccs1.,C[C@H](C[NH+]1CCCCC1)NC(=O)c1cccs1,amide
89622,Please remove a amide from the molecule CCc1ccc([C@H](C)C(=O)N(CCC(N)=O)c2ccc(F)cc2)cc1.,CCc1ccc([C@H](C)C(=O)N(CCC(N)=O)c2ccc(F)cc2)cc1,amide
77428,Remove a benzene_ring from the molecule CC[C@H](NC(=O)c1ccc(CNC(C)=O)cc1)c1cccc(Cl)c1.,CC[C@H](NC(=O)c1ccc(CNC(C)=O)cc1)c1cccc(Cl)c1,benzene_ring
225010,Modify the molecule CC(C)c1[nH+]ccn1CCN1CCN(C(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)CC1 by removing a benzene_ring.,CC(C)c1[nH+]ccn1CCN1CCN(C(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)CC1,benzene_ring
111314,Remove a halo from the molecule COc1ccc(CN2CCN(C(=O)Cn3cncn3)CC2)cc1F.,COc1ccc(CN2CCN(C(=O)Cn3cncn3)CC2)cc1F,halo
134416,Modify the molecule CC1(CNc2ccc([N+](=O)[O-])c(N)n2)CCCC1 by removing a nitro.,CC1(CNc2ccc([N+](=O)[O-])c(N)n2)CCCC1,nitro
161325,Remove a benzene_ring from the molecule Cc1ccc(C(=O)N2CCN(C(=O)Nc3cccc(C)c3)CC2)cc1.,Cc1ccc(C(=O)N2CCN(C(=O)Nc3cccc(C)c3)CC2)cc1,benzene_ring
179631,Remove a halo from the molecule Cc1nn(C)cc1-c1cc(C(F)(F)F)nc(N2CCC[C@@H]2C(=O)[O-])n1.,Cc1nn(C)cc1-c1cc(C(F)(F)F)nc(N2CCC[C@@H]2C(=O)[O-])n1,halo
204911,Remove a amine from the molecule CN[C@@]1(C(=O)OC)CCC[C@@H]([NH+]2CCC(COC)CC2)C1.,CN[C@@]1(C(=O)OC)CCC[C@@H]([NH+]2CCC(COC)CC2)C1,amine
162366,Remove a nitrile from the molecule CC(C)[C@H](C#N)NC(=O)[C@]1(C)CCCO1.,CC(C)[C@H](C#N)NC(=O)[C@]1(C)CCCO1,nitrile
170525,Modify the molecule CCc1ccccc1NC(=O)C(=O)NCc1ccccc1Cn1cccn1 by removing a benzene_ring.,CCc1ccccc1NC(=O)C(=O)NCc1ccccc1Cn1cccn1,benzene_ring
7057,Remove a halo from the molecule CC[C@H]([NH2+]C1CCSCC1)c1ccc(Cl)cc1.,CC[C@H]([NH2+]C1CCSCC1)c1ccc(Cl)cc1,halo
192128,Modify the molecule C[NH+](C1CCCC1)[C@H]1CC[C@]([NH3+])(CO)C1 by removing a hydroxyl.,C[NH+](C1CCCC1)[C@H]1CC[C@]([NH3+])(CO)C1,hydroxyl
111284,Remove a amide from the molecule CCOc1cccc2sc(N(C[C@H]3CCCO3)C(=O)[C@@H]3Oc4ccccc4O[C@H]3C)nc12.,CCOc1cccc2sc(N(C[C@H]3CCCO3)C(=O)[C@@H]3Oc4ccccc4O[C@H]3C)nc12,amide
211389,Please remove a benzene_ring from the molecule CCn1cc(-c2c(-c3ccccc3)ncn2CCNC(=O)c2cccnc2)cn1.,CCn1cc(-c2c(-c3ccccc3)ncn2CCNC(=O)c2cccnc2)cn1,benzene_ring
88105,Modify the molecule COc1ccccc1CNc1ccc(NC(=O)[C@@H]2CCCO2)cc1 by removing a amide.,COc1ccccc1CNc1ccc(NC(=O)[C@@H]2CCCO2)cc1,amide
128496,Modify the molecule Cc1ccc2c(c1)c(=O)c(S(=O)(=O)c1ccccc1)cn2CC(=O)Nc1ccc(C)c(Cl)c1 by removing a benzene_ring.,Cc1ccc2c(c1)c(=O)c(S(=O)(=O)c1ccccc1)cn2CC(=O)Nc1ccc(C)c(Cl)c1,benzene_ring
229326,Please remove a benzene_ring from the molecule CC(=O)NCCNC(=O)NCc1ccc(CN2CCc3ccccc32)cc1.,CC(=O)NCCNC(=O)NCc1ccc(CN2CCc3ccccc32)cc1,benzene_ring
116547,Please remove a halo from the molecule COc1cc(Cl)c(C)cc1NC(=O)CS(=O)(=O)Cc1cc(C)ccc1C.,COc1cc(Cl)c(C)cc1NC(=O)CS(=O)(=O)Cc1cc(C)ccc1C,halo
193531,Remove a amide from the molecule COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(F)c(Cl)c1.,COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(F)c(Cl)c1,amide
135060,Modify the molecule C[C@H](c1ccncc1)[NH+](C)CC(=O)N[C@@H](c1ccc(F)cc1)C1CCCC1 by removing a halo.,C[C@H](c1ccncc1)[NH+](C)CC(=O)N[C@@H](c1ccc(F)cc1)C1CCCC1,halo
40400,Please remove a benzene_ring from the molecule C[C@@H](NC(=O)NCC(=O)Nc1ccccc1)c1ccc(Cl)s1.,C[C@@H](NC(=O)NCC(=O)Nc1ccccc1)c1ccc(Cl)s1,benzene_ring
98636,Remove a amide from the molecule C[C@H](O)[C@@H](C)SCC(=O)Nc1ccccc1C(=O)Nc1ccccc1.,C[C@H](O)[C@@H](C)SCC(=O)Nc1ccccc1C(=O)Nc1ccccc1,amide
13713,Remove a halo from the molecule COc1cc(C(=O)[O-])cc(-c2cc(Cl)ccc2OC)c1.,COc1cc(C(=O)[O-])cc(-c2cc(Cl)ccc2OC)c1,halo
18965,Please remove a amide from the molecule Cc1cccc(C(=O)N[C@@H]2CCCC[C@@H]2C(F)(F)F)n1.,Cc1cccc(C(=O)N[C@@H]2CCCC[C@@H]2C(F)(F)F)n1,amide
10545,Modify the molecule O=C(CNC(=O)N[C@@H]1C[C@H]1c1cccc(Cl)c1)NCc1ccccc1 by removing a amide.,O=C(CNC(=O)N[C@@H]1C[C@H]1c1cccc(Cl)c1)NCc1ccccc1,amide
95249,Modify the molecule CC1(C)CCC([NH+]2CCCC[C@@H]2CC(N)=O)CC1 by removing a amide.,CC1(C)CCC([NH+]2CCCC[C@@H]2CC(N)=O)CC1,amide
35403,Remove a amide from the molecule O=C(Nc1ccccc1N1CCCC1)c1ccc(-n2cncn2)nc1.,O=C(Nc1ccccc1N1CCCC1)c1ccc(-n2cncn2)nc1,amide
110550,Please remove a amide from the molecule C[C@H](CC(=O)N(C)[C@H]1CCCC[C@@H]1S(C)(=O)=O)n1cccc1.,C[C@H](CC(=O)N(C)[C@H]1CCCC[C@@H]1S(C)(=O)=O)n1cccc1,amide
157314,Remove a benzene_ring from the molecule CCc1nc(-c2cccc(OC)c2)nc(CC)c1CC[NH3+].,CCc1nc(-c2cccc(OC)c2)nc(CC)c1CC[NH3+],benzene_ring
161878,Please remove a nitro from the molecule O=[N+]([O-])c1ccc(S(=O)(=O)NC[C@](O)(c2ccccc2)C(F)(F)F)cc1.,O=[N+]([O-])c1ccc(S(=O)(=O)NC[C@](O)(c2ccccc2)C(F)(F)F)cc1,nitro
111711,Remove a amide from the molecule O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)c1cc2c([nH]c1=O)CCCC2.,O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)c1cc2c([nH]c1=O)CCCC2,amide
82715,Modify the molecule OC/C=C(\Cl)c1ccc(Cl)cc1Cl by removing a halo.,OC/C=C(\Cl)c1ccc(Cl)cc1Cl,halo
242509,Remove a benzene_ring from the molecule CCC[NH+]1CCC(CNC(=O)C(=O)Nc2ccc(F)c(C(N)=O)c2)CC1.,CCC[NH+]1CCC(CNC(=O)C(=O)Nc2ccc(F)c(C(N)=O)c2)CC1,benzene_ring
170787,Remove a amine from the molecule CCCN1C(N)=[NH+]C[C@]12CC(C)(C)OC2(C)C.,CCCN1C(N)=[NH+]C[C@]12CC(C)(C)OC2(C)C,amine
232277,Please remove a hydroxyl from the molecule O=C1N[C@@H](C(=O)NC[C@@H](O)c2cc(Cl)cc(Cl)c2)CS1.,O=C1N[C@@H](C(=O)NC[C@@H](O)c2cc(Cl)cc(Cl)c2)CS1,hydroxyl
141952,Remove a amine from the molecule CNc1cccc(COc2cncc(Cl)c2)[nH+]1.,CNc1cccc(COc2cncc(Cl)c2)[nH+]1,amine
214265,Please remove a benzene_ring from the molecule CCOc1cc(C=O)cc(Br)c1OC(=O)c1ccccc1Cl.,CCOc1cc(C=O)cc(Br)c1OC(=O)c1ccccc1Cl,benzene_ring
240981,Remove a amide from the molecule COc1cccc(NC(=O)CCN2C(=O)[C@@H]3Cc4cc(OC)c(OC)cc4CN3C2=O)c1.,COc1cccc(NC(=O)CCN2C(=O)[C@@H]3Cc4cc(OC)c(OC)cc4CN3C2=O)c1,amide
11121,Remove a amide from the molecule N#Cc1ccc(NC(=O)c2c3c(nc4ccccc24)CCC3)cc1Cl.,N#Cc1ccc(NC(=O)c2c3c(nc4ccccc24)CCC3)cc1Cl,amide
186509,Please remove a amide from the molecule CC(C)[C@@H](CNC(=O)C(=O)Nc1ccccc1)N1CC[NH+](C)CC1.,CC(C)[C@@H](CNC(=O)C(=O)Nc1ccccc1)N1CC[NH+](C)CC1,amide
38200,Remove a hydroxyl from the molecule Cc1nc2ncnn2c(N2CCC(O)(C(F)(F)F)CC2)c1C.,Cc1nc2ncnn2c(N2CCC(O)(C(F)(F)F)CC2)c1C,hydroxyl
26496,Remove a amide from the molecule Cc1cc([C@H](C)NC(=O)C2CC=CC2)c(C)o1.,Cc1cc([C@H](C)NC(=O)C2CC=CC2)c(C)o1,amide
215221,Please remove a benzene_ring from the molecule COc1ccccc1CNC(=O)NCc1ccc(OC(C)C)nc1.,COc1ccccc1CNC(=O)NCc1ccc(OC(C)C)nc1,benzene_ring
203226,Remove a amide from the molecule COc1ccc(NC(=O)C[C@@H](NC(C)=O)c2ccc(Cl)cc2)c(OC)c1.,COc1ccc(NC(=O)C[C@@H](NC(C)=O)c2ccc(Cl)cc2)c(OC)c1,amide
135649,Modify the molecule CN1C(SCc2ccc(Cl)c(Cl)c2)=N[C@@H]2CS(=O)(=O)C[C@H]21 by removing a benzene_ring.,CN1C(SCc2ccc(Cl)c(Cl)c2)=N[C@@H]2CS(=O)(=O)C[C@H]21,benzene_ring
135961,Modify the molecule Cc1ccc2c(c1)C(=O)N(CCCC(=O)Nc1ccc(C#N)cc1)C2=O by removing a amide.,Cc1ccc2c(c1)C(=O)N(CCCC(=O)Nc1ccc(C#N)cc1)C2=O,amide
227770,Please remove a amide from the molecule C[C@@H]1CCC[C@@H](NC(=O)c2ccc3c(c2)NC(=O)CO3)C1.,C[C@@H]1CCC[C@@H](NC(=O)c2ccc3c(c2)NC(=O)CO3)C1,amide
164491,Remove a amide from the molecule C[C@@H](O)C[NH+]1CCC2(CCC(=O)N(Cc3ccccc3)C2)CC1.,C[C@@H](O)C[NH+]1CCC2(CCC(=O)N(Cc3ccccc3)C2)CC1,amide
27378,Modify the molecule C[C@H](C(=O)c1ccc(F)cc1F)n1cnc2c1c(=O)n(C)c(=O)n2C by removing a halo.,C[C@H](C(=O)c1ccc(F)cc1F)n1cnc2c1c(=O)n(C)c(=O)n2C,halo
37077,Remove a amide from the molecule O=C(NCc1ccc2c3c(cccc13)C(=O)N2)c1ccc(F)cc1.,O=C(NCc1ccc2c3c(cccc13)C(=O)N2)c1ccc(F)cc1,amide
9996,Remove a benzene_ring from the molecule C[C@H]1C[C@@H]1C(=O)N1CCN(C(=O)CNC(=O)c2ccc(C#N)cc2)CC1.,C[C@H]1C[C@@H]1C(=O)N1CCN(C(=O)CNC(=O)c2ccc(C#N)cc2)CC1,benzene_ring
34805,Please remove a benzene_ring from the molecule O=C(NC[C@@H]1COC2(CCCC2)O1)Nc1c(F)cccc1Oc1ccccc1.,O=C(NC[C@@H]1COC2(CCCC2)O1)Nc1c(F)cccc1Oc1ccccc1,benzene_ring
219022,Modify the molecule CCOc1ccc([C@H]2CCCN2C(=O)Nc2ccc(OC)c(C)c2)cc1 by removing a benzene_ring.,CCOc1ccc([C@H]2CCCN2C(=O)Nc2ccc(OC)c(C)c2)cc1,benzene_ring
34732,Modify the molecule O=C(CCNC(=O)c1cc2cccc(Cl)c2o1)NCc1ccccc1 by removing a halo.,O=C(CCNC(=O)c1cc2cccc(Cl)c2o1)NCc1ccccc1,halo
174383,Please remove a amine from the molecule CNc1ccc(CN2CC[C@@H](CN3CCOCC3)C2)cc1[N+](=O)[O-].,CNc1ccc(CN2CC[C@@H](CN3CCOCC3)C2)cc1[N+](=O)[O-],amine
345,Please remove a amide from the molecule Cn1c(=O)c(=O)n(CC(=O)N2CCC3(CC2)OCCO3)c2cccnc21.,Cn1c(=O)c(=O)n(CC(=O)N2CCC3(CC2)OCCO3)c2cccnc21,amide
163982,Please remove a benzene_ring from the molecule COc1ccc(SCCC(=O)Oc2ccc3ccc(=O)oc3c2)cc1.,COc1ccc(SCCC(=O)Oc2ccc3ccc(=O)oc3c2)cc1,benzene_ring
222733,Remove a benzene_ring from the molecule CC[C@H](CNC(=O)c1ccc([N+](=O)[O-])cc1F)c1ccccc1.,CC[C@H](CNC(=O)c1ccc([N+](=O)[O-])cc1F)c1ccccc1,benzene_ring
9072,Remove a amide from the molecule C[C@@H]1CN(C(=O)Cn2cc([N+](=O)[O-])cn2)CCO1.,C[C@@H]1CN(C(=O)Cn2cc([N+](=O)[O-])cn2)CCO1,amide
213306,Please remove a amide from the molecule CCCNC(=O)CNC(=O)Nc1ccccc1N1CC[NH+](CC)CC1.,CCCNC(=O)CNC(=O)Nc1ccccc1N1CC[NH+](CC)CC1,amide
176380,Please remove a benzene_ring from the molecule C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)Nc1nc2ccccc2s1.,C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)Nc1nc2ccccc2s1,benzene_ring
106472,Modify the molecule CN(C)c1ccc(/C=N/NC(=O)CSc2nnc(-c3ccncc3)n2N)cc1 by removing a benzene_ring.,CN(C)c1ccc(/C=N/NC(=O)CSc2nnc(-c3ccncc3)n2N)cc1,benzene_ring
181514,Please remove a amide from the molecule C[NH+](CC(=O)NC(=O)Nc1ccc2c(c1)OCCO2)CC(=O)Nc1c(Cl)cccc1Cl.,C[NH+](CC(=O)NC(=O)Nc1ccc2c(c1)OCCO2)CC(=O)Nc1c(Cl)cccc1Cl,amide
120310,Remove a amine from the molecule COc1ccc(C2=N[NH+]=C(N3CCN(C(=O)C(C)C)CC3)SC2)cc1.,COc1ccc(C2=N[NH+]=C(N3CCN(C(=O)C(C)C)CC3)SC2)cc1,amine
235767,Please remove a benzene_ring from the molecule Cc1ccc(NC(=O)[C@@H]2C=C(c3ccncc3)N=N2)cc1N(C)C.,Cc1ccc(NC(=O)[C@@H]2C=C(c3ccncc3)N=N2)cc1N(C)C,benzene_ring
192424,Modify the molecule CN(CC[NH+](C)C1CCCCC1)C(=O)CCn1nnc2ccccc2c1=O by removing a amide.,CN(CC[NH+](C)C1CCCCC1)C(=O)CCn1nnc2ccccc2c1=O,amide
203330,Remove a benzene_ring from the molecule CCc1nnc(N2C(=O)c3oc4cc(OC)ccc4c(=O)c3[C@H]2c2cccc([N+](=O)[O-])c2)s1.,CCc1nnc(N2C(=O)c3oc4cc(OC)ccc4c(=O)c3[C@H]2c2cccc([N+](=O)[O-])c2)s1,benzene_ring
159447,Modify the molecule CCOC(=O)c1c(-c2ccc3ccccc3c2)csc1NC(=O)c1cccnc1 by removing a amide.,CCOC(=O)c1c(-c2ccc3ccccc3c2)csc1NC(=O)c1cccnc1,amide
103915,Please remove a benzene_ring from the molecule COc1ccc(S(=O)(=O)N2CCN(c3ccccc3OC)CC2)cc1F.,COc1ccc(S(=O)(=O)N2CCN(c3ccccc3OC)CC2)cc1F,benzene_ring
134219,Please remove a hydroxyl from the molecule N#Cc1ccc(N2CCC(O)CC2)cc1.,N#Cc1ccc(N2CCC(O)CC2)cc1,hydroxyl
245734,Please remove a amide from the molecule COC(=O)C[C@@H]1Oc2ccccc2N(Cc2snnc2C(C)C)C1=O.,COC(=O)C[C@@H]1Oc2ccccc2N(Cc2snnc2C(C)C)C1=O,amide
71099,Remove a halo from the molecule Cc1[nH]nc(C(N)=O)c1NC(=O)CCC(F)(F)F.,Cc1[nH]nc(C(N)=O)c1NC(=O)CCC(F)(F)F,halo
92395,Please remove a benzene_ring from the molecule C=CCOc1ccc(/C=C(\C#N)C(=O)c2c[nH]c3ccccc23)cc1.,C=CCOc1ccc(/C=C(\C#N)C(=O)c2c[nH]c3ccccc23)cc1,benzene_ring
162610,Please remove a amide from the molecule Cc1ccc(C2(O)CC[NH+](CC(=O)N3C[C@H](C)O[C@H](C)C3)CC2)nc1.,Cc1ccc(C2(O)CC[NH+](CC(=O)N3C[C@H](C)O[C@H](C)C3)CC2)nc1,amide
52632,Remove a amide from the molecule CCN(CC)c1ccc(C(=O)Nc2ccc3oc(COC)nc3c2)cn1.,CCN(CC)c1ccc(C(=O)Nc2ccc3oc(COC)nc3c2)cn1,amide
193822,Please remove a amide from the molecule O=C(C1=C([O-])C(=O)N(CC[NH+]2CCCCC2)[C@@H]1c1cccnc1)C1CC1.,O=C(C1=C([O-])C(=O)N(CC[NH+]2CCCCC2)[C@@H]1c1cccnc1)C1CC1,amide
103266,Please remove a benzene_ring from the molecule Cc1ccc(Cn2cc(-n3c([S-])nnc3[C@@H](C)Cn3nc(C(F)(F)F)cc3C)cn2)cc1.,Cc1ccc(Cn2cc(-n3c([S-])nnc3[C@@H](C)Cn3nc(C(F)(F)F)cc3C)cn2)cc1,benzene_ring
177142,Modify the molecule Cc1cc2c(N(C)CC(=O)NC(C)(C)C)ncnc2s1 by removing a amide.,Cc1cc2c(N(C)CC(=O)NC(C)(C)C)ncnc2s1,amide
124601,Please remove a halo from the molecule C[C@@H]1CCCN(C(=O)Nc2ccc(F)c(Br)c2)[C@H]1CO.,C[C@@H]1CCCN(C(=O)Nc2ccc(F)c(Br)c2)[C@H]1CO,halo
164508,Please remove a benzene_ring from the molecule COc1ccc(CCNc2ncnc3sc(C(=O)[O-])c(C)c23)cc1OC.,COc1ccc(CCNc2ncnc3sc(C(=O)[O-])c(C)c23)cc1OC,benzene_ring
237961,Please remove a amide from the molecule CCN1C(=O)c2ccc(C(=O)N(C)[C@H](C)c3ccccc3)cc2S1(=O)=O.,CCN1C(=O)c2ccc(C(=O)N(C)[C@H](C)c3ccccc3)cc2S1(=O)=O,amide
58944,Remove a amine from the molecule CCOc1ccc([C@H]2C(C#N)=C(N)Oc3cc(OC(=O)[C@@H]4COc5ccccc5O4)ccc32)cc1.,CCOc1ccc([C@H]2C(C#N)=C(N)Oc3cc(OC(=O)[C@@H]4COc5ccccc5O4)ccc32)cc1,amine
66675,Please remove a amide from the molecule Cc1cc(C)cc(NC(=O)c2ccc(NC(=O)[C@H]3[C@@H]4C[C@@H]5OC(=O)[C@@H]3[C@@H]5C4)cc2)c1.,Cc1cc(C)cc(NC(=O)c2ccc(NC(=O)[C@H]3[C@@H]4C[C@@H]5OC(=O)[C@@H]3[C@@H]5C4)cc2)c1,amide
42218,Remove a benzene_ring from the molecule O=S(=O)(N[C@H]1CCCc2ccccc21)c1ccc(F)cc1.,O=S(=O)(N[C@H]1CCCc2ccccc21)c1ccc(F)cc1,benzene_ring
37390,Remove a benzene_ring from the molecule CCc1ccccc1NC(=O)Cn1c(C)nc2c(sc3nc(-c4ccccc4)ccc32)c1=O.,CCc1ccccc1NC(=O)Cn1c(C)nc2c(sc3nc(-c4ccccc4)ccc32)c1=O,benzene_ring
201612,Modify the molecule Cc1cc(=O)n(C)cc1NC(=O)[C@H]1CCCN(C(=O)c2ccccc2)C1 by removing a benzene_ring.,Cc1cc(=O)n(C)cc1NC(=O)[C@H]1CCCN(C(=O)c2ccccc2)C1,benzene_ring
231839,Modify the molecule CC(=O)Nc1sc2ccccc2c1Br by removing a halo.,CC(=O)Nc1sc2ccccc2c1Br,halo
207693,Remove a benzene_ring from the molecule COc1ccccc1-c1nc(C[NH2+][C@H](C)C(C)(C)C)cs1.,COc1ccccc1-c1nc(C[NH2+][C@H](C)C(C)(C)C)cs1,benzene_ring
83603,Please remove a halo from the molecule CCOC(=O)[C@@H]1CCCN(C(=O)Nc2ccc(OCC)c(Cl)c2)C1.,CCOC(=O)[C@@H]1CCCN(C(=O)Nc2ccc(OCC)c(Cl)c2)C1,halo
221747,Modify the molecule NC(=O)[C@@H](CNC(=O)c1cc(F)ccc1O)Cc1ccc(F)cc1 by removing a benzene_ring.,NC(=O)[C@@H](CNC(=O)c1cc(F)ccc1O)Cc1ccc(F)cc1,benzene_ring
152878,Modify the molecule C[C@@H](O)c1cc2cccc3c2n(c1=O)CCC3 by removing a hydroxyl.,C[C@@H](O)c1cc2cccc3c2n(c1=O)CCC3,hydroxyl
87568,Remove a amide from the molecule CN1CCN(C(=O)c2cnn(-c3ccccc3)c2)[C@@H](c2ccccc2)C1.,CN1CCN(C(=O)c2cnn(-c3ccccc3)c2)[C@@H](c2ccccc2)C1,amide
8009,Modify the molecule COc1ccc(Br)cc1-c1nnc2n(Cc3ccccc3)c3c(=O)n(C)c(=O)n(C)c3n12 by removing a benzene_ring.,COc1ccc(Br)cc1-c1nnc2n(Cc3ccccc3)c3c(=O)n(C)c(=O)n(C)c3n12,benzene_ring
140113,Remove a nitro from the molecule O=C([O-])CCCC(=O)Nc1ccc([N+](=O)[O-])cc1.,O=C([O-])CCCC(=O)Nc1ccc([N+](=O)[O-])cc1,nitro
73996,Modify the molecule Cc1ccc(C(=O)OC[C@H]2COC(C)(C)O2)c(F)c1 by removing a benzene_ring.,Cc1ccc(C(=O)OC[C@H]2COC(C)(C)O2)c(F)c1,benzene_ring
87765,Remove a amide from the molecule CNC(=O)c1ccc(CSCc2cccc(NC(C)=O)c2)cc1.,CNC(=O)c1ccc(CSCc2cccc(NC(C)=O)c2)cc1,amide
230370,Please remove a benzene_ring from the molecule C[C@@]1(C(=O)Nc2ccc(C#N)cc2)Oc2ccccc2NC1=O.,C[C@@]1(C(=O)Nc2ccc(C#N)cc2)Oc2ccccc2NC1=O,benzene_ring
22736,Please remove a hydroxyl from the molecule Cc1cncc(NC(=O)C(=O)N[C@@H]2CCCC[C@H]2O)c1.,Cc1cncc(NC(=O)C(=O)N[C@@H]2CCCC[C@H]2O)c1,hydroxyl
72565,Remove a halo from the molecule Cc1cccc2c1[nH]c1nc(SCC(=O)Nc3ccc(Cl)cc3)nnc12.,Cc1cccc2c1[nH]c1nc(SCC(=O)Nc3ccc(Cl)cc3)nnc12,halo
206552,Remove a amide from the molecule COc1ccc(NC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cn1.,COc1ccc(NC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cn1,amide
36286,Remove a benzene_ring from the molecule COc1cc(Br)c([C@H]2OCC[C@@H]2CO)cc1OC.,COc1cc(Br)c([C@H]2OCC[C@@H]2CO)cc1OC,benzene_ring
125055,Remove a hydroxyl from the molecule N#Cc1ccc(N2C(=O)[C@H]3[C@@H](C2=O)[C@@H]2C=C[C@@]3(CO)O2)cc1.,N#Cc1ccc(N2C(=O)[C@H]3[C@@H](C2=O)[C@@H]2C=C[C@@]3(CO)O2)cc1,hydroxyl
401,Modify the molecule COCCNC(=O)/C(C#N)=C/c1cccc(O)c1 by removing a amide.,COCCNC(=O)/C(C#N)=C/c1cccc(O)c1,amide
83201,Modify the molecule CCOC(=O)c1cccc(NC[C@H](O)c2ccco2)n1 by removing a amine.,CCOC(=O)c1cccc(NC[C@H](O)c2ccco2)n1,amine
97477,Please remove a amide from the molecule CCc1ccc(C(=O)N2CSC[C@H]2C(=O)[O-])o1.,CCc1ccc(C(=O)N2CSC[C@H]2C(=O)[O-])o1,amide
187284,Please remove a benzene_ring from the molecule COc1ccc(C[NH+](C)Cc2nc(-c3ccc(C)s3)oc2C)cc1OC.,COc1ccc(C[NH+](C)Cc2nc(-c3ccc(C)s3)oc2C)cc1OC,benzene_ring
179385,Please remove a halo from the molecule Cc1nn(C2CCC2)c2cc(F)ccc12.,Cc1nn(C2CCC2)c2cc(F)ccc12,halo
211197,Modify the molecule CCSc1cncc(NCc2scnc2C)n1 by removing a amine.,CCSc1cncc(NCc2scnc2C)n1,amine
105886,Remove a nitrile from the molecule C/C(=C\C(=O)NCc1cc(C#N)ccc1F)CCc1ccccc1.,C/C(=C\C(=O)NCc1cc(C#N)ccc1F)CCc1ccccc1,nitrile
171750,Modify the molecule CC[C@@H]([NH2+][C@@H](C)c1nc2cc(Cl)ccc2n1C)C(=O)N1CCOCC1 by removing a halo.,CC[C@@H]([NH2+][C@@H](C)c1nc2cc(Cl)ccc2n1C)C(=O)N1CCOCC1,halo
127760,Please remove a benzene_ring from the molecule COc1ccc(CN(C(=S)Nc2c(C)cc(C)cc2C)C2CC[NH+](C)CC2)cc1.,COc1ccc(CN(C(=S)Nc2c(C)cc(C)cc2C)C2CC[NH+](C)CC2)cc1,benzene_ring
149781,Modify the molecule CC(C)CCC(=O)N1CCN(C(=O)N[C@@H](C)c2ccc(C#N)cc2)CC1 by removing a amide.,CC(C)CCC(=O)N1CCN(C(=O)N[C@@H](C)c2ccc(C#N)cc2)CC1,amide
22704,Modify the molecule CN(C)C(=O)CN(C)C(=O)Cc1coc(-c2ccccc2)n1 by removing a amide.,CN(C)C(=O)CN(C)C(=O)Cc1coc(-c2ccccc2)n1,amide
200920,Please remove a amine from the molecule Cc1c[nH+]c(NCc2ccc(C#N)cc2)nc1NCc1ccc(C#N)cc1.,Cc1c[nH+]c(NCc2ccc(C#N)cc2)nc1NCc1ccc(C#N)cc1,amine
196344,Please remove a amine from the molecule FC(F)(F)C1(C(F)(F)F)CCN(Cc2cnn3c2NCCC3)C1.,FC(F)(F)C1(C(F)(F)F)CCN(Cc2cnn3c2NCCC3)C1,amine
36265,Remove a benzene_ring from the molecule O=S(=O)(/C=C/c1ccc(Cl)cc1)NCc1ccc2ccccc2c1.,O=S(=O)(/C=C/c1ccc(Cl)cc1)NCc1ccc2ccccc2c1,benzene_ring
79510,Modify the molecule Cc1ccccc1OCC(=O)O[C@H](C)C[NH+]1CCOCC1 by removing a benzene_ring.,Cc1ccccc1OCC(=O)O[C@H](C)C[NH+]1CCOCC1,benzene_ring
226277,Please remove a hydroxyl from the molecule O=c1c2ccccc2ncn1CC(O)Cn1cnc2ccccc2c1=O.,O=c1c2ccccc2ncn1CC(O)Cn1cnc2ccccc2c1=O,hydroxyl
4837,Remove a amide from the molecule O=C(COc1ccc([N+](=O)[O-])cc1Cl)NC1CCCCCCC1.,O=C(COc1ccc([N+](=O)[O-])cc1Cl)NC1CCCCCCC1,amide
227713,Please remove a benzene_ring from the molecule CN(C[C@@H]1C=NN=C1c1ccccc1)C(=O)c1cccc(C#CC(C)(C)O)c1.,CN(C[C@@H]1C=NN=C1c1ccccc1)C(=O)c1cccc(C#CC(C)(C)O)c1,benzene_ring
60773,Please remove a amide from the molecule O=C(Nc1cccnc1)c1ccccc1-c1ccccc1.,O=C(Nc1cccnc1)c1ccccc1-c1ccccc1,amide
1550,Remove a amine from the molecule COc1ccc(N)cc1-c1ccccc1.,COc1ccc(N)cc1-c1ccccc1,amine
22494,Remove a amide from the molecule Cc1cccc(C2=CCN(C(=O)c3cnn(C)c3-n3cccc3)CC2)c1.,Cc1cccc(C2=CCN(C(=O)c3cnn(C)c3-n3cccc3)CC2)c1,amide
130219,Remove a halo from the molecule COCC[C@@H](C)NC(=O)Nc1cc(F)ccc1OC.,COCC[C@@H](C)NC(=O)Nc1cc(F)ccc1OC,halo
159867,Remove a amine from the molecule CN1CCO[C@H](COc2ccc(CC(N)=S)cc2)C1.,CN1CCO[C@H](COc2ccc(CC(N)=S)cc2)C1,amine
183153,Modify the molecule CC[C@H](Nc1nnnn1-c1ccccc1)C(=O)NC[C@@H]1CCCO1 by removing a amide.,CC[C@H](Nc1nnnn1-c1ccccc1)C(=O)NC[C@@H]1CCCO1,amide
193899,Please remove a amide from the molecule CCC[C@H](NC(=O)CSc1nc2ccccc2n(C)c1=O)c1cccs1.,CCC[C@H](NC(=O)CSc1nc2ccccc2n(C)c1=O)c1cccs1,amide
9240,Modify the molecule CS(=O)(=O)[C@@H]1CCC[C@@H](Nc2ncnc3[nH]cnc23)C1 by removing a amine.,CS(=O)(=O)[C@@H]1CCC[C@@H](Nc2ncnc3[nH]cnc23)C1,amine
34972,Modify the molecule Cc1cscc1C(=O)Nc1ccc(C#CC[NH3+])cc1 by removing a benzene_ring.,Cc1cscc1C(=O)Nc1ccc(C#CC[NH3+])cc1,benzene_ring
86098,Please remove a benzene_ring from the molecule C[C@@](N)(C(=O)OCc1ccc(Cl)cc1)C(F)(F)F.,C[C@@](N)(C(=O)OCc1ccc(Cl)cc1)C(F)(F)F,benzene_ring
113391,Remove a benzene_ring from the molecule CCCOCC(=O)Nc1cc(C(N)=O)ccc1C.,CCCOCC(=O)Nc1cc(C(N)=O)ccc1C,benzene_ring
220037,Modify the molecule O=C(C[NH+]1CCC[C@H](C(F)(F)F)C1)Nc1nccs1 by removing a amide.,O=C(C[NH+]1CCC[C@H](C(F)(F)F)C1)Nc1nccs1,amide
224290,Please remove a amide from the molecule CCCCc1nc(C)c(C(=O)N(CC(N)=O)C2CCCC2)s1.,CCCCc1nc(C)c(C(=O)N(CC(N)=O)C2CCCC2)s1,amide
195871,Remove a amine from the molecule N/N=C1\C[C@@H](c2ccccc2)Oc2ccccc21.,N/N=C1\C[C@@H](c2ccccc2)Oc2ccccc21,amine
119328,Remove a halo from the molecule C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)Nc1cc3c(cc1Cl)OCCCO3)CC2.,C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)Nc1cc3c(cc1Cl)OCCCO3)CC2,halo
104665,Please remove a amine from the molecule CC1(C)C[C@@H](Nc2cc(S(C)(=O)=O)ccc2Cl)C(C)(C)O1.,CC1(C)C[C@@H](Nc2cc(S(C)(=O)=O)ccc2Cl)C(C)(C)O1,amine
118940,Please remove a hydroxyl from the molecule O=S(=O)(c1cccc(Br)c1)N1CCN(C[C@H](O)c2ccccc2F)CC1.,O=S(=O)(c1cccc(Br)c1)N1CCN(C[C@H](O)c2ccccc2F)CC1,hydroxyl
94135,Modify the molecule C=C(Br)CN1CCC[C@H]1CN1CCOCC1 by removing a halo.,C=C(Br)CN1CCC[C@H]1CN1CCOCC1,halo
9827,Please remove a benzene_ring from the molecule O=C1C[C@@H](C(=O)N2CCC[C@@H](O)C2)CN1CCc1ccccc1.,O=C1C[C@@H](C(=O)N2CCC[C@@H](O)C2)CN1CCc1ccccc1,benzene_ring
170686,Please remove a amine from the molecule Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)cc2)cc1[N+](=O)[O-].,Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)cc2)cc1[N+](=O)[O-],amine
2468,Please remove a benzene_ring from the molecule Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1.,Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1,benzene_ring
216559,Modify the molecule COc1cccc(N2C[C@@H](C(=O)N3CCCSC[C@H]3C[NH+](C)C)CC2=O)c1 by removing a amide.,COc1cccc(N2C[C@@H](C(=O)N3CCCSC[C@H]3C[NH+](C)C)CC2=O)c1,amide
144956,Remove a benzene_ring from the molecule C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@@H](c2ccccc2)O1.,C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@@H](c2ccccc2)O1,benzene_ring
103069,Please remove a amide from the molecule O=C(CCC(=O)c1cccs1)N[C@H]1CCCN(Cc2ccccc2)C1=O.,O=C(CCC(=O)c1cccs1)N[C@H]1CCCN(Cc2ccccc2)C1=O,amide
64531,Please remove a benzene_ring from the molecule COc1ccc(S(=O)(=O)N2CCc3ccccc3C2)c(Cl)c1Cl.,COc1ccc(S(=O)(=O)N2CCc3ccccc3C2)c(Cl)c1Cl,benzene_ring
44767,Modify the molecule CCOc1ccc(/C=N/NC(=O)CNC(=O)c2ccccc2I)cc1 by removing a benzene_ring.,CCOc1ccc(/C=N/NC(=O)CNC(=O)c2ccccc2I)cc1,benzene_ring
141568,Please remove a benzene_ring from the molecule Cc1nc(C[C@H](O)CCOc2ccccc2)sc1C.,Cc1nc(C[C@H](O)CCOc2ccccc2)sc1C,benzene_ring
244287,Remove a amide from the molecule Cc1cc(C)n(-c2ccc(N3CCN(C(=O)c4ccc(F)cc4F)CC3)nn2)n1.,Cc1cc(C)n(-c2ccc(N3CCN(C(=O)c4ccc(F)cc4F)CC3)nn2)n1,amide
76494,Modify the molecule c1ccc(-c2nc(SCc3cn4cccnc4n3)oc2-c2ccccc2)cc1 by removing a benzene_ring.,c1ccc(-c2nc(SCc3cn4cccnc4n3)oc2-c2ccccc2)cc1,benzene_ring
11971,Please remove a halo from the molecule CCCNC(=O)CN1C(=O)/C(=N\NC(=O)c2ccccc2Cl)c2ccccc21.,CCCNC(=O)CN1C(=O)/C(=N\NC(=O)c2ccccc2Cl)c2ccccc21,halo
246749,Please remove a benzene_ring from the molecule C[C@H](Cc1cccc(F)c1)C(=O)NCC(C)(C)c1ccccc1F.,C[C@H](Cc1cccc(F)c1)C(=O)NCC(C)(C)c1ccccc1F,benzene_ring
111693,Please remove a benzene_ring from the molecule COc1cccc(C(=O)Cn2c(=O)c(C#N)cn(C3CC3)c2=O)c1.,COc1cccc(C(=O)Cn2c(=O)c(C#N)cn(C3CC3)c2=O)c1,benzene_ring
91267,Please remove a amide from the molecule C[C@H]1CN(C(=O)/C=C/c2ccc(N3CCCC3=O)cc2)C(C)(C)CO1.,C[C@H]1CN(C(=O)/C=C/c2ccc(N3CCCC3=O)cc2)C(C)(C)CO1,amide
240168,Remove a benzene_ring from the molecule C/[NH+]=C(/NCC(=O)Nc1ccc(F)cc1)N[C@@H]1C[C@H]1C.,C/[NH+]=C(/NCC(=O)Nc1ccc(F)cc1)N[C@@H]1C[C@H]1C,benzene_ring
186219,Modify the molecule CCOc1cc(C(=O)NCc2cccc(OC)c2)ccc1OC by removing a benzene_ring.,CCOc1cc(C(=O)NCc2cccc(OC)c2)ccc1OC,benzene_ring
202987,Please remove a halo from the molecule Cc1ccc(C)c(NC(=O)N[C@@H]2CC(=O)N(c3cccc(F)c3)C2)c1.,Cc1ccc(C)c(NC(=O)N[C@@H]2CC(=O)N(c3cccc(F)c3)C2)c1,halo
156220,Please remove a amide from the molecule Cc1cc(NC(=O)c2ccc(-n3cncn3)nc2)ccc1N(C)C.,Cc1cc(NC(=O)c2ccc(-n3cncn3)nc2)ccc1N(C)C,amide
61376,Modify the molecule Cc1nc(C)c(CNS(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)s1 by removing a amine.,Cc1nc(C)c(CNS(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)s1,amine
15960,Modify the molecule CN1C(=O)N[C@@H](c2ccccc2Cl)C2=C1CN(CC(=O)NCc1ccccc1)C2=O by removing a benzene_ring.,CN1C(=O)N[C@@H](c2ccccc2Cl)C2=C1CN(CC(=O)NCc1ccccc1)C2=O,benzene_ring
164353,Remove a halo from the molecule CCOc1nnc(CN2CCN(c3ncccc3F)CC2)s1.,CCOc1nnc(CN2CCN(c3ncccc3F)CC2)s1,halo
51821,Remove a benzene_ring from the molecule CN(C)c1cc(C(=O)Nc2ccc([S@](C)=O)cc2)ccn1.,CN(C)c1cc(C(=O)Nc2ccc([S@](C)=O)cc2)ccn1,benzene_ring
29411,Remove a benzene_ring from the molecule COc1cccc(CN(C)S(=O)(=O)c2ccc(C(C)C)cc2)c1.,COc1cccc(CN(C)S(=O)(=O)c2ccc(C(C)C)cc2)c1,benzene_ring
108000,Please remove a benzene_ring from the molecule O=C(/C=C/C1CCOCC1)NC1(c2ccc(F)cc2F)CCCC1.,O=C(/C=C/C1CCOCC1)NC1(c2ccc(F)cc2F)CCCC1,benzene_ring
199314,Please remove a benzene_ring from the molecule CC[C@@](C)([C@H](N)Cc1cccc(Br)c1)[NH+]1CCCCC1.,CC[C@@](C)([C@H](N)Cc1cccc(Br)c1)[NH+]1CCCCC1,benzene_ring
119380,Please remove a amide from the molecule CSc1ccc2cc(CN3C(=O)N[C@](C)(c4ccco4)C3=O)c(Cl)nc2c1.,CSc1ccc2cc(CN3C(=O)N[C@](C)(c4ccco4)C3=O)c(Cl)nc2c1,amide
23503,Modify the molecule CCCN1C(=O)c2[nH]nc(-c3cc(C)ccc3O)c2[C@@H]1c1ccc(C)cc1 by removing a amide.,CCCN1C(=O)c2[nH]nc(-c3cc(C)ccc3O)c2[C@@H]1c1ccc(C)cc1,amide
17624,Modify the molecule CC(C)NC(=O)c1ccc(-c2nc3cc(NS(=O)(=O)Cc4cccc(F)c4)ccc3n2C)cc1 by removing a amine.,CC(C)NC(=O)c1ccc(-c2nc3cc(NS(=O)(=O)Cc4cccc(F)c4)ccc3n2C)cc1,amine
133814,Remove a halo from the molecule Cc1cccc(OCc2nnc(SCc3cc(F)cc4cccnc34)o2)c1.,Cc1cccc(OCc2nnc(SCc3cc(F)cc4cccnc34)o2)c1,halo
164487,Please remove a amide from the molecule CC(C)NC(=S)NC(=O)c1ccc(OC(C)C)c(Br)c1.,CC(C)NC(=S)NC(=O)c1ccc(OC(C)C)c(Br)c1,amide
139612,Remove a amide from the molecule CCS(=O)(=O)N1CCC[C@@H](C(=O)NC2CCCCCC2)C1.,CCS(=O)(=O)N1CCC[C@@H](C(=O)NC2CCCCCC2)C1,amide
213423,Please remove a amine from the molecule COc1ccc(NC(=S)NC(=O)c2ccccc2Br)cc1OC.,COc1ccc(NC(=S)NC(=O)c2ccccc2Br)cc1OC,amine
236197,Please remove a amine from the molecule Cn1ccnc1Sc1ccc(N)c(N)n1.,Cn1ccnc1Sc1ccc(N)c(N)n1,amine
189903,Remove a amine from the molecule c1cc(CCCNc2ccc(-c3nc(C4CC4)no3)c[nH+]2)ccn1.,c1cc(CCCNc2ccc(-c3nc(C4CC4)no3)c[nH+]2)ccn1,amine
231511,Please remove a amine from the molecule N/C(=[NH+]\[N-]S(=O)(=O)c1ccccc1OC(F)(F)F)c1ccc(C(F)(F)F)cn1.,N/C(=[NH+]\[N-]S(=O)(=O)c1ccccc1OC(F)(F)F)c1ccc(C(F)(F)F)cn1,amine
226748,Remove a nitrile from the molecule Cc1csc([C@@H](C#N)C(=O)c2ccc(F)c(F)c2)n1.,Cc1csc([C@@H](C#N)C(=O)c2ccc(F)c(F)c2)n1,nitrile
189255,Please remove a halo from the molecule C[C@H]1CC(OCc2cc(F)cc(C#CC[NH3+])c2)C[C@H](C)C1.,C[C@H]1CC(OCc2cc(F)cc(C#CC[NH3+])c2)C[C@H](C)C1,halo
211036,Please remove a nitrile from the molecule COc1ccccc1NC(=O)[C@H](C)Oc1ccccc1C#N.,COc1ccccc1NC(=O)[C@H](C)Oc1ccccc1C#N,nitrile
170177,Remove a halo from the molecule Cc1cc(NC(=O)CCc2cnn(C)c2C)ncc1Br.,Cc1cc(NC(=O)CCc2cnn(C)c2C)ncc1Br,halo
17564,Please remove a halo from the molecule Cc1cnc(C(C)(C)NC(=O)CCCOc2ccccc2Cl)s1.,Cc1cnc(C(C)(C)NC(=O)CCCOc2ccccc2Cl)s1,halo
184207,Remove a amide from the molecule Cc1ccc(-c2cc(N)c(=O)n(CC(=O)N3[C@@H](C)CCC[C@@H]3C)n2)s1.,Cc1ccc(-c2cc(N)c(=O)n(CC(=O)N3[C@@H](C)CCC[C@@H]3C)n2)s1,amide
242164,Remove a halo from the molecule C[C@@H](Cn1cncn1)NC(=O)Nc1cc(F)cc(N2CCCC2)c1.,C[C@@H](Cn1cncn1)NC(=O)Nc1cc(F)cc(N2CCCC2)c1,halo
229826,Modify the molecule CC(C)CNC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1 by removing a nitrile.,CC(C)CNC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1,nitrile
209382,Please remove a hydroxyl from the molecule CC[C@H](O)C[C@@H](Cc1ccccc1OC)C(=O)[O-].,CC[C@H](O)C[C@@H](Cc1ccccc1OC)C(=O)[O-],hydroxyl
143109,Remove a amide from the molecule CC(C)(CNC(=O)NC[C@H]1CCN(c2ccccc2)C1)C(N)=O.,CC(C)(CNC(=O)NC[C@H]1CCN(c2ccccc2)C1)C(N)=O,amide
172903,Remove a amide from the molecule COc1ccc(NC(=O)c2cc(C)cc(OC)c2O)c(Cl)c1.,COc1ccc(NC(=O)c2cc(C)cc(OC)c2O)c(Cl)c1,amide
73774,Modify the molecule CCOC1CCN(C(=O)/C=C(/C)c2ccccc2OC(F)F)CC1 by removing a halo.,CCOC1CCN(C(=O)/C=C(/C)c2ccccc2OC(F)F)CC1,halo
188219,Modify the molecule O=C([C@@H]1COc2ccc(F)cc2C1)N1CCC[C@@H]1c1ccccc1 by removing a halo.,O=C([C@@H]1COc2ccc(F)cc2C1)N1CCC[C@@H]1c1ccccc1,halo
23100,Modify the molecule COc1cc(C)c(S(=O)(=O)N[C@@H](C#N)c2ccccc2F)cc1OC by removing a nitrile.,COc1cc(C)c(S(=O)(=O)N[C@@H](C#N)c2ccccc2F)cc1OC,nitrile
90821,Remove a amide from the molecule NC(=O)c1cccc(OCC(=O)N[C@@H](c2ccc3c(c2)CCCC3)c2cccs2)c1.,NC(=O)c1cccc(OCC(=O)N[C@@H](c2ccc3c(c2)CCCC3)c2cccs2)c1,amide
127089,Remove a amide from the molecule CSc1ccc(C(=O)NC[C@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)cc1.,CSc1ccc(C(=O)NC[C@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)cc1,amide
80126,Please remove a benzene_ring from the molecule Cc1ccccc1C(=O)NC(=S)Nc1sc2c(c1C#N)CCCC2.,Cc1ccccc1C(=O)NC(=S)Nc1sc2c(c1C#N)CCCC2,benzene_ring
54301,Please remove a benzene_ring from the molecule Cc1ccc(/N=C2/S[C@@H](CC(=O)Nc3ccc(C(=O)[O-])cc3)C(=O)N2C)cc1.,Cc1ccc(/N=C2/S[C@@H](CC(=O)Nc3ccc(C(=O)[O-])cc3)C(=O)N2C)cc1,benzene_ring
187788,Please remove a amide from the molecule Cc1cc(NC(=O)[C@@H](C)N2CCO[C@H](C)C2)ccc1Br.,Cc1cc(NC(=O)[C@@H](C)N2CCO[C@H](C)C2)ccc1Br,amide
5588,Please remove a amide from the molecule Cc1nc(COc2ccccc2)sc1C(=O)N1CCOCC1.,Cc1nc(COc2ccccc2)sc1C(=O)N1CCOCC1,amide
36098,Modify the molecule C[C@@H](SCC1=NC(=O)C2=C(c3ccccc3)CSC2=N1)C(=O)N1CCN(c2nccs2)CC1 by removing a amide.,C[C@@H](SCC1=NC(=O)C2=C(c3ccccc3)CSC2=N1)C(=O)N1CCN(c2nccs2)CC1,amide
229895,Remove a hydroxyl from the molecule CC[NH+](CC(=O)c1c(C)cc(C)cc1C)CC(C)(C)O.,CC[NH+](CC(=O)c1c(C)cc(C)cc1C)CC(C)(C)O,hydroxyl
95726,Modify the molecule CC1(C)CCC[C@H]1NS(=O)(=O)c1ccc(CC(=O)[O-])cc1 by removing a benzene_ring.,CC1(C)CCC[C@H]1NS(=O)(=O)c1ccc(CC(=O)[O-])cc1,benzene_ring
135709,Remove a hydroxyl from the molecule CC[S@@](=O)[C@H]1CCCC[C@@H]1NC(=O)NCc1ccc(OC)c(O)c1.,CC[S@@](=O)[C@H]1CCCC[C@@H]1NC(=O)NCc1ccc(OC)c(O)c1,hydroxyl
138859,Please remove a benzene_ring from the molecule CCc1nnc(NC(=O)c2c(C)c(-c3ccccc3)nc3ccccc23)s1.,CCc1nnc(NC(=O)c2c(C)c(-c3ccccc3)nc3ccccc23)s1,benzene_ring
189348,Modify the molecule [NH3+]C[C@H](Cc1ccccc1)Cc1cccc(O)c1 by removing a benzene_ring.,[NH3+]C[C@H](Cc1ccccc1)Cc1cccc(O)c1,benzene_ring
248830,Remove a amide from the molecule O=C(N[C@@H]1CCCCC[C@H]1C(=O)[O-])C1CC1.,O=C(N[C@@H]1CCCCC[C@H]1C(=O)[O-])C1CC1,amide
80131,Please remove a hydroxyl from the molecule CC(=O)N1c2ccccc2C[C@H]1C(=O)N(Cc1ccccc1)[C@@H](C)CCO.,CC(=O)N1c2ccccc2C[C@H]1C(=O)N(Cc1ccccc1)[C@@H](C)CCO,hydroxyl
165272,Please remove a halo from the molecule COc1ccc(F)c(N[C@H](C)c2sc(C)nc2C)c1.,COc1ccc(F)c(N[C@H](C)c2sc(C)nc2C)c1,halo
3095,Remove a nitrile from the molecule CC(C)S(=O)(=O)CC(=O)N1CCN(c2ncccc2C#N)CC1.,CC(C)S(=O)(=O)CC(=O)N1CCN(c2ncccc2C#N)CC1,nitrile
151507,Modify the molecule C[C@H](CCNC(=O)c1cccc[n+]1[O-])c1cccc(C(F)(F)F)c1 by removing a halo.,C[C@H](CCNC(=O)c1cccc[n+]1[O-])c1cccc(C(F)(F)F)c1,halo
175575,Modify the molecule CC(C)CNC(=O)CN1CC[NH2+]CC1 by removing a amide.,CC(C)CNC(=O)CN1CC[NH2+]CC1,amide
48859,Modify the molecule CC(C)c1noc([C@@H]2CCC(=O)N(CCCN3CCCC3=O)C2)n1 by removing a amide.,CC(C)c1noc([C@@H]2CCC(=O)N(CCCN3CCCC3=O)C2)n1,amide
181487,Modify the molecule Cc1ccc([C@@]2(C)NC(=O)N(Cc3cccc(F)c3)C2=O)cc1 by removing a amide.,Cc1ccc([C@@]2(C)NC(=O)N(Cc3cccc(F)c3)C2=O)cc1,amide
25319,Modify the molecule COC(=O)[C@@H]1CN(C(=O)c2ccc(Br)s2)C[C@H]1C by removing a halo.,COC(=O)[C@@H]1CN(C(=O)c2ccc(Br)s2)C[C@H]1C,halo
75233,Modify the molecule Cc1cc(Cl)cc(C)c1Oc1cc([C@H](C)O)ccn1 by removing a hydroxyl.,Cc1cc(Cl)cc(C)c1Oc1cc([C@H](C)O)ccn1,hydroxyl
146025,Please remove a benzene_ring from the molecule Cc1cc(C)n(-c2cccc(NC(=O)NC3CCCCCC3)c2)n1.,Cc1cc(C)n(-c2cccc(NC(=O)NC3CCCCCC3)c2)n1,benzene_ring
29889,Please remove a amide from the molecule Cc1ccccc1OCC(=O)Nc1cccc(C(=O)N(C)c2ccccc2)c1.,Cc1ccccc1OCC(=O)Nc1cccc(C(=O)N(C)c2ccccc2)c1,amide
116194,Remove a amide from the molecule C[C@H]1CCN(C(=O)CCc2nc(-c3ncccn3)no2)[C@H](C)C1.,C[C@H]1CCN(C(=O)CCc2nc(-c3ncccn3)no2)[C@H](C)C1,amide
199131,Modify the molecule Cn1cnc(CNC(=O)[C@@H](OC(C)(C)C)c2ccccc2)n1 by removing a benzene_ring.,Cn1cnc(CNC(=O)[C@@H](OC(C)(C)C)c2ccccc2)n1,benzene_ring
146330,Modify the molecule C[C@H](CC(=O)[O-])N1C(=O)S/C(=C\c2ccc(Cl)cc2)C1=O by removing a benzene_ring.,C[C@H](CC(=O)[O-])N1C(=O)S/C(=C\c2ccc(Cl)cc2)C1=O,benzene_ring
62490,Modify the molecule [NH3+][C@@H](c1cc(F)cc(Br)c1)[C@H]1CCOC2(CCOCC2)C1 by removing a benzene_ring.,[NH3+][C@@H](c1cc(F)cc(Br)c1)[C@H]1CCOC2(CCOCC2)C1,benzene_ring
15490,Please remove a amide from the molecule CC(C)C(=O)N1CCc2c(c(C(=O)N3CCC(C(=O)NC4CCCCCC4)CC3)nn2C)C1.,CC(C)C(=O)N1CCc2c(c(C(=O)N3CCC(C(=O)NC4CCCCCC4)CC3)nn2C)C1,amide
188195,Please remove a benzene_ring from the molecule COC[C@@H](NCc1ccc(OC)c(C#N)c1)c1ccc(F)c(F)c1.,COC[C@@H](NCc1ccc(OC)c(C#N)c1)c1ccc(F)c(F)c1,benzene_ring
208264,Please remove a amide from the molecule CC[C@H](C(=O)NCc1cc(-c2ccccc2)on1)c1ccccc1.,CC[C@H](C(=O)NCc1cc(-c2ccccc2)on1)c1ccccc1,amide
145414,Please remove a halo from the molecule COc1ccc([C@H](CNS(=O)(=O)c2ccc(C)cc2Cl)N2CCOCC2)cc1.,COc1ccc([C@H](CNS(=O)(=O)c2ccc(C)cc2Cl)N2CCOCC2)cc1,halo
71679,Please remove a amide from the molecule CCc1nnc(S[C@@H](CC)C(=O)NCc2ccco2)c2cc3occc3n12.,CCc1nnc(S[C@@H](CC)C(=O)NCc2ccco2)c2cc3occc3n12,amide
213878,Modify the molecule CNC(=O)[C@@H](C)Oc1ccc(C[NH2+]C2CC2)cc1 by removing a amide.,CNC(=O)[C@@H](C)Oc1ccc(C[NH2+]C2CC2)cc1,amide
59275,Remove a halo from the molecule CC1=C/C(=N\OC(=O)c2ccccc2Cl)C(C(C)C)=CC1=O.,CC1=C/C(=N\OC(=O)c2ccccc2Cl)C(C(C)C)=CC1=O,halo
84342,Please remove a benzene_ring from the molecule Cc1ccc(C)c(OC2CCN(Cc3scnc3C)CC2)c1.,Cc1ccc(C)c(OC2CCN(Cc3scnc3C)CC2)c1,benzene_ring
90011,Remove a benzene_ring from the molecule Cc1ccccc1NC(=O)N(C1CC1)[C@@H](C)c1ccco1.,Cc1ccccc1NC(=O)N(C1CC1)[C@@H](C)c1ccco1,benzene_ring
244338,Remove a halo from the molecule C[C@H](OCC(F)(F)F)C(=O)N1CCC(c2ccc(F)cc2)CC1.,C[C@H](OCC(F)(F)F)C(=O)N1CCC(c2ccc(F)cc2)CC1,halo
108614,Please remove a benzene_ring from the molecule C[C@@H]1C[C@@H](C)C[NH+](Cc2ccccc2CNC(=O)N2CCO[C@H](C)C2)C1.,C[C@@H]1C[C@@H](C)C[NH+](Cc2ccccc2CNC(=O)N2CCO[C@H](C)C2)C1,benzene_ring
216748,Modify the molecule CC(C)Cc1ccc(-c2ccc(N)cc2)cc1 by removing a amine.,CC(C)Cc1ccc(-c2ccc(N)cc2)cc1,amine
79908,Modify the molecule O=C(CSc1cc(N2CCCC2)ncn1)Nc1cccc(Cl)c1 by removing a amide.,O=C(CSc1cc(N2CCCC2)ncn1)Nc1cccc(Cl)c1,amide
215264,Remove a amide from the molecule CC(=O)c1c(C)[nH]c(C(=O)NC2CCC(O)CC2)c1C.,CC(=O)c1c(C)[nH]c(C(=O)NC2CCC(O)CC2)c1C,amide
114102,Modify the molecule CC[C@@H]([NH2+][C@@H](COC)c1ccc(F)c(F)c1)c1cnn(C)c1 by removing a benzene_ring.,CC[C@@H]([NH2+][C@@H](COC)c1ccc(F)c(F)c1)c1cnn(C)c1,benzene_ring
94699,Remove a halo from the molecule Cc1ccc(NC(=O)[C@H](C)S(=O)(=O)Cc2c(C)nn(C)c2Cl)cc1C.,Cc1ccc(NC(=O)[C@H](C)S(=O)(=O)Cc2c(C)nn(C)c2Cl)cc1C,halo
185291,Modify the molecule C[C@@H]1[NH2+]CCC[C@@H]1C(=O)Nc1ccc(CCO)cc1 by removing a benzene_ring.,C[C@@H]1[NH2+]CCC[C@@H]1C(=O)Nc1ccc(CCO)cc1,benzene_ring
142664,Please remove a benzene_ring from the molecule N#Cc1ccccc1/C([O-])=N/S(=O)(=O)N1CCc2ccccc2C1.,N#Cc1ccccc1/C([O-])=N/S(=O)(=O)N1CCc2ccccc2C1,benzene_ring
220183,Modify the molecule Cc1ccc(NC(=O)NC[C@@H](C)Oc2ccccc2F)s1 by removing a benzene_ring.,Cc1ccc(NC(=O)NC[C@@H](C)Oc2ccccc2F)s1,benzene_ring
12362,Remove a benzene_ring from the molecule C[C@H]1CC(C(=O)NCc2ccc(OCc3ccccn3)cc2)C[C@H](C)O1.,C[C@H]1CC(C(=O)NCc2ccc(OCc3ccccn3)cc2)C[C@H](C)O1,benzene_ring
12371,Remove a halo from the molecule COc1ccc(-c2cnc(SCC(=O)Nc3ccc(F)c(F)c3)n2C)cc1.,COc1ccc(-c2cnc(SCC(=O)Nc3ccc(F)c(F)c3)n2C)cc1,halo
121697,Remove a amide from the molecule Cc1ccc(CC(=O)N2CCC[C@H]2Cn2nc(C)cc2C)cn1.,Cc1ccc(CC(=O)N2CCC[C@H]2Cn2nc(C)cc2C)cn1,amide
155595,Modify the molecule N#C[C@@H]1CN([C@H]2CCN(CC(F)(F)F)C2=O)CCO1 by removing a halo.,N#C[C@@H]1CN([C@H]2CCN(CC(F)(F)F)C2=O)CCO1,halo
93279,Modify the molecule Cc1nc(CNc2nc(-c3ccccn3)nc3c2CC[NH+](C)CC3)n[nH]1 by removing a amine.,Cc1nc(CNc2nc(-c3ccccn3)nc3c2CC[NH+](C)CC3)n[nH]1,amine
132771,Modify the molecule COc1ccc(/N=N/c2cc(C)ccc2O)cc1 by removing a benzene_ring.,COc1ccc(/N=N/c2cc(C)ccc2O)cc1,benzene_ring
117253,Please remove a nitro from the molecule N[C@H]1CCCn2c1nc1cc([N+](=O)[O-])ccc1c2=O.,N[C@H]1CCCn2c1nc1cc([N+](=O)[O-])ccc1c2=O,nitro
21457,Modify the molecule CSc1ccc(Cl)c(C(=O)OCc2ccc(Cl)nc2)c1 by removing a halo.,CSc1ccc(Cl)c(C(=O)OCc2ccc(Cl)nc2)c1,halo
139363,Please remove a halo from the molecule CC[C@@H](NC(=O)CSc1nnnn1C)c1cc(F)ccc1F.,CC[C@@H](NC(=O)CSc1nnnn1C)c1cc(F)ccc1F,halo
195140,Please remove a amide from the molecule C[C@H](NC(=O)c1cc(-c2cccs2)nc2ccccc12)[C@@H](C)N1CCOCC1.,C[C@H](NC(=O)c1cc(-c2cccs2)nc2ccccc12)[C@@H](C)N1CCOCC1,amide
76192,Modify the molecule CNC(=O)NCC(=O)N1CC[NH+](C2CCC(C)CC2)CC1 by removing a amide.,CNC(=O)NCC(=O)N1CC[NH+](C2CCC(C)CC2)CC1,amide
164455,Modify the molecule Oc1ccc(C[NH+]2CCC[C@H]2C[C@@H](O)c2ccco2)c(O)c1 by removing a benzene_ring.,Oc1ccc(C[NH+]2CCC[C@H]2C[C@@H](O)c2ccco2)c(O)c1,benzene_ring
11633,Modify the molecule CC1=[N+]2C(=N)/C(=C/c3ccc(-c4cc([N+](=O)[O-])ccc4C)o3)C(=O)N=C2SC1 by removing a nitro.,CC1=[N+]2C(=N)/C(=C/c3ccc(-c4cc([N+](=O)[O-])ccc4C)o3)C(=O)N=C2SC1,nitro
122788,Modify the molecule Cc1ccc([N+](=O)[O-])c(NC(=O)[C@@H](C)[NH+]2CCCCCC2)c1C by removing a benzene_ring.,Cc1ccc([N+](=O)[O-])c(NC(=O)[C@@H](C)[NH+]2CCCCCC2)c1C,benzene_ring
209514,Remove a amine from the molecule COc1cc(OC)cc(-c2cc(N)n(S(=O)(=O)c3ccc(OC)c(OC)c3)n2)c1.,COc1cc(OC)cc(-c2cc(N)n(S(=O)(=O)c3ccc(OC)c(OC)c3)n2)c1,amine
60066,Remove a hydroxyl from the molecule Cc1cc([C@@H]2NC(=O)NC2=N)cc(C)c1O.,Cc1cc([C@@H]2NC(=O)NC2=N)cc(C)c1O,hydroxyl
248049,Modify the molecule O=C(Cc1ccc(S(=O)(=O)N2CCCC2)s1)N1CCC[C@H](O)C1 by removing a amide.,O=C(Cc1ccc(S(=O)(=O)N2CCCC2)s1)N1CCC[C@H](O)C1,amide
116620,Remove a hydroxyl from the molecule Cc1csc(Cn2ccc([C@@H](O)C(C)C)c2)n1.,Cc1csc(Cn2ccc([C@@H](O)C(C)C)c2)n1,hydroxyl
117401,Please remove a amide from the molecule CCn1nc(C(=O)N2CCC(C(N)=O)CC2)ccc1=O.,CCn1nc(C(=O)N2CCC(C(N)=O)CC2)ccc1=O,amide
194065,Modify the molecule C[NH2+][C@@H]1[C@H](C[NH+](C)C[C@@H](C)O)CCC1(C)C by removing a hydroxyl.,C[NH2+][C@@H]1[C@H](C[NH+](C)C[C@@H](C)O)CCC1(C)C,hydroxyl
175427,Modify the molecule CCC[NH2+][C@@H](C)c1cccc(O[C@@H]2CCCCNC2=O)c1 by removing a amide.,CCC[NH2+][C@@H](C)c1cccc(O[C@@H]2CCCCNC2=O)c1,amide
11014,Modify the molecule COc1ccc(/C=N/NC(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)cc1 by removing a benzene_ring.,COc1ccc(/C=N/NC(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)cc1,benzene_ring
52268,Remove a amide from the molecule C[C@@H](C(=O)NC1CCCCC1)[S@@](=O)Cc1nnnn1C1CC1.,C[C@@H](C(=O)NC1CCCCC1)[S@@](=O)Cc1nnnn1C1CC1,amide
151283,Please remove a amide from the molecule CN(Cc1ccccc1)C(=O)CN(c1cccc(Cl)c1Cl)S(=O)(=O)c1ccccc1.,CN(Cc1ccccc1)C(=O)CN(c1cccc(Cl)c1Cl)S(=O)(=O)c1ccccc1,amide
172431,Please remove a amide from the molecule O=C(/C=C/c1ccco1)Nc1ccc(NC(=O)c2ccco2)cc1.,O=C(/C=C/c1ccco1)Nc1ccc(NC(=O)c2ccco2)cc1,amide
111261,Remove a amide from the molecule Cc1nn(Cc2ccccc2)c(C)c1CNc1cncc(C(N)=O)n1.,Cc1nn(Cc2ccccc2)c(C)c1CNc1cncc(C(N)=O)n1,amide
202606,Remove a halo from the molecule O=[N+]([O-])c1cc(Br)ccc1N1CC[C@H](O)C1.,O=[N+]([O-])c1cc(Br)ccc1N1CC[C@H](O)C1,halo
160909,Please remove a amide from the molecule CN1C(=O)C([C@@H]2c3c(n(C)c(=O)n(C)c3=O)Oc3ccc4ccccc4c32)C(=O)N(C)C1=O.,CN1C(=O)C([C@@H]2c3c(n(C)c(=O)n(C)c3=O)Oc3ccc4ccccc4c32)C(=O)N(C)C1=O,amide
119368,Please remove a amide from the molecule Cc1noc(COCC(=O)N2CCSC[C@@H]2c2ccc(C)o2)n1.,Cc1noc(COCC(=O)N2CCSC[C@@H]2c2ccc(C)o2)n1,amide
52925,Please remove a benzene_ring from the molecule Cc1ccc(N/C(=N/C(=O)c2ccc(C)cc2)NC[C@@H]2CCCO2)cc1.,Cc1ccc(N/C(=N/C(=O)c2ccc(C)cc2)NC[C@@H]2CCCO2)cc1,benzene_ring
237254,Please remove a amide from the molecule O=C1CC[C@@]2(CCCN(C(=O)c3c[nH]c(=O)cn3)C2)CN1Cc1cccnc1.,O=C1CC[C@@]2(CCCN(C(=O)c3c[nH]c(=O)cn3)C2)CN1Cc1cccnc1,amide
67026,Please remove a benzene_ring from the molecule Cc1ccc(-c2noc(C[S@@](=O)[C@H](C)c3ccccc3)n2)cc1F.,Cc1ccc(-c2noc(C[S@@](=O)[C@H](C)c3ccccc3)n2)cc1F,benzene_ring
79148,Modify the molecule CC(C)Oc1ncnc(N(C)[C@H]2CCS(=O)(=O)C2)c1N by removing a amine.,CC(C)Oc1ncnc(N(C)[C@H]2CCS(=O)(=O)C2)c1N,amine
134302,Please remove a halo from the molecule CC[C@@H](C)n1c([C@@H]2CCC[NH2+]2)nc2cc(C(F)(F)F)ccc21.,CC[C@@H](C)n1c([C@@H]2CCC[NH2+]2)nc2cc(C(F)(F)F)ccc21,halo
245164,Modify the molecule N#Cc1cc(S(N)(=O)=O)ccc1NC[C@@H]1CCC[C@@H]1O by removing a hydroxyl.,N#Cc1cc(S(N)(=O)=O)ccc1NC[C@@H]1CCC[C@@H]1O,hydroxyl
72817,Modify the molecule C[C@H](NC(=O)c1cccc(C(N)=O)c1)C(c1ccccc1)c1ccccc1 by removing a benzene_ring.,C[C@H](NC(=O)c1cccc(C(N)=O)c1)C(c1ccccc1)c1ccccc1,benzene_ring
201411,Modify the molecule O=C(Cc1ccon1)N[C@H](c1ccc(F)cc1)[C@H]1CCCO1 by removing a benzene_ring.,O=C(Cc1ccon1)N[C@H](c1ccc(F)cc1)[C@H]1CCCO1,benzene_ring
160269,Please remove a benzene_ring from the molecule CCOC(=O)c1cnc2nc(C)ccc2c1Nc1ccc(S(N)(=O)=O)cc1.,CCOC(=O)c1cnc2nc(C)ccc2c1Nc1ccc(S(N)(=O)=O)cc1,benzene_ring
235514,Modify the molecule CN1C(=O)C(=Cc2c(N3CCCCC3)nc3ccccn3c2=O)C(=O)N(C)C1=O by removing a amide.,CN1C(=O)C(=Cc2c(N3CCCCC3)nc3ccccn3c2=O)C(=O)N(C)C1=O,amide
17035,Please remove a amide from the molecule CC(C)(C)NC(=O)N1CC[C@@]2(C1)C(=O)Nc1ccccc12.,CC(C)(C)NC(=O)N1CC[C@@]2(C1)C(=O)Nc1ccccc12,amide
76762,Please remove a benzene_ring from the molecule CC1(C)CC(=O)C2=C(C1)OC(/N=C/N1CCCC1)=C(C#N)[C@H]2c1ccccc1.,CC1(C)CC(=O)C2=C(C1)OC(/N=C/N1CCCC1)=C(C#N)[C@H]2c1ccccc1,benzene_ring
136540,Modify the molecule Cc1cc(Sc2nncn2C)ncc1N by removing a amine.,Cc1cc(Sc2nncn2C)ncc1N,amine
6203,Please remove a halo from the molecule O=C(CCC(=O)N1CCN(c2ccccc2F)CC1)c1ccc(Cl)s1.,O=C(CCC(=O)N1CCN(c2ccccc2F)CC1)c1ccc(Cl)s1,halo
44341,Please remove a amide from the molecule CC1=C(C)C[C@H]2C(=O)N(c3ccccc3C)C(=O)[C@H]2C1.,CC1=C(C)C[C@H]2C(=O)N(c3ccccc3C)C(=O)[C@H]2C1,amide
211331,Please remove a amide from the molecule COC(=O)c1ccsc1NC(=O)c1ccsc1NC(=O)c1cccs1.,COC(=O)c1ccsc1NC(=O)c1ccsc1NC(=O)c1cccs1,amide
1814,Modify the molecule Cc1ccccc1N1CCN(C(=O)[C@@]23CC[C@@H](C[C@@H]2Br)C3)CC1 by removing a amide.,Cc1ccccc1N1CCN(C(=O)[C@@]23CC[C@@H](C[C@@H]2Br)C3)CC1,amide
235828,Please remove a nitrile from the molecule COc1ccc(C(=O)c2c(C)c(C#N)c(=O)n([C@@H](C)c3ccccc3)c2[O-])cc1.,COc1ccc(C(=O)c2c(C)c(C#N)c(=O)n([C@@H](C)c3ccccc3)c2[O-])cc1,nitrile
224397,Remove a halo from the molecule CC(=O)N1CCCN(C(=O)C(=O)Nc2cccc(Cl)c2Cl)CC1.,CC(=O)N1CCCN(C(=O)C(=O)Nc2cccc(Cl)c2Cl)CC1,halo
172210,Remove a halo from the molecule CCCCN(C)C(=O)N[C@H]1CCCc2ccc(F)cc21.,CCCCN(C)C(=O)N[C@H]1CCCc2ccc(F)cc21,halo
40891,Remove a benzene_ring from the molecule Cc1ccc(C(C)(C)C(=O)O[C@H](C)c2ccccn2)cc1.,Cc1ccc(C(C)(C)C(=O)O[C@H](C)c2ccccn2)cc1,benzene_ring
25218,Modify the molecule CCc1ccc(N(C(C)=O)c2nc(CSc3nnc(C(F)(F)F)n3N)cs2)cc1 by removing a halo.,CCc1ccc(N(C(C)=O)c2nc(CSc3nnc(C(F)(F)F)n3N)cs2)cc1,halo
207471,Please remove a halo from the molecule O=S(=O)([N-]c1nc2ccccc2nc1Cl)c1ccc2ccccc2c1.,O=S(=O)([N-]c1nc2ccccc2nc1Cl)c1ccc2ccccc2c1,halo
168980,Modify the molecule CCSc1nc(CC(=O)N2CCC3(CC2)OCCC[C@@H]3OC)cs1 by removing a amide.,CCSc1nc(CC(=O)N2CCC3(CC2)OCCC[C@@H]3OC)cs1,amide
130573,Modify the molecule C[C@@H]1CC(C)(C)C[C@@]2(C1)NC(=O)N(CN1CCc3sccc3C1)C2=O by removing a amide.,C[C@@H]1CC(C)(C)C[C@@]2(C1)NC(=O)N(CN1CCc3sccc3C1)C2=O,amide
20167,Remove a benzene_ring from the molecule NC(=O)[C@@H]1CCC[NH+]1[C@H](C(=O)[O-])c1c[nH]c2cc(NC(=O)c3ccccc3)ccc12.,NC(=O)[C@@H]1CCC[NH+]1[C@H](C(=O)[O-])c1c[nH]c2cc(NC(=O)c3ccccc3)ccc12,benzene_ring
125620,Remove a amide from the molecule CCn1cc(CN2CCO[C@H](c3cc(C(=O)NCC(C)C)c4ccccc4n3)C2)cn1.,CCn1cc(CN2CCO[C@H](c3cc(C(=O)NCC(C)C)c4ccccc4n3)C2)cn1,amide
168709,Modify the molecule CC1=NN2C(=N)/C(=C\c3cc(C)n(-c4ccc(Cl)cc4)c3C)C(=O)N=C2S1 by removing a halo.,CC1=NN2C(=N)/C(=C\c3cc(C)n(-c4ccc(Cl)cc4)c3C)C(=O)N=C2S1,halo
211104,Remove a nitrile from the molecule N#CCc1nc2cc(C(F)(F)F)c(C#N)cc2s1.,N#CCc1nc2cc(C(F)(F)F)c(C#N)cc2s1,nitrile
131676,Remove a amine from the molecule CCc1nn(C)c(OC)c1CN[C@H](C)c1ccnc(Cl)c1.,CCc1nn(C)c(OC)c1CN[C@H](C)c1ccnc(Cl)c1,amine
140159,Modify the molecule COc1ccc2c(c1)[C@H](O)[C@@H]([NH+]1CCCC(C)(C)C1)CC2 by removing a hydroxyl.,COc1ccc2c(c1)[C@H](O)[C@@H]([NH+]1CCCC(C)(C)C1)CC2,hydroxyl
20890,Modify the molecule COC(=O)c1ccc(C[NH2+][C@@H]2CCCC[C@H]2C(F)(F)F)[nH]1 by removing a halo.,COC(=O)c1ccc(C[NH2+][C@@H]2CCCC[C@H]2C(F)(F)F)[nH]1,halo
100634,Modify the molecule CCCCc1ccc(NC(=O)NCc2n[nH]c(=S)n2C(C)C)cc1 by removing a benzene_ring.,CCCCc1ccc(NC(=O)NCc2n[nH]c(=S)n2C(C)C)cc1,benzene_ring
182021,Modify the molecule N#Cc1cccc(C(=O)N2CCN(Cc3noc(-c4cccc(Cl)c4)n3)CC2)c1 by removing a amide.,N#Cc1cccc(C(=O)N2CCN(Cc3noc(-c4cccc(Cl)c4)n3)CC2)c1,amide
141700,Please remove a amide from the molecule O=C(N[C@H]1CCOc2ccccc21)c1cnc([C@@H]2CCCO2)s1.,O=C(N[C@H]1CCOc2ccccc21)c1cnc([C@@H]2CCCO2)s1,amide
31522,Modify the molecule Cc1cc(N2CCCC[C@@H]2C)n2nc(-c3ccccc3C)nc2n1 by removing a benzene_ring.,Cc1cc(N2CCCC[C@@H]2C)n2nc(-c3ccccc3C)nc2n1,benzene_ring
155577,Remove a amide from the molecule CCNC(=O)c1ccc(N(CCC[NH3+])C2CC2)[nH+]n1.,CCNC(=O)c1ccc(N(CCC[NH3+])C2CC2)[nH+]n1,amide
125064,Remove a benzene_ring from the molecule CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O.,CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O,benzene_ring
4641,Modify the molecule CN(CC1CC[NH+](C)CC1)[C@@H](C[NH3+])c1cc(Cl)cs1 by removing a halo.,CN(CC1CC[NH+](C)CC1)[C@@H](C[NH3+])c1cc(Cl)cs1,halo
192817,Please remove a amine from the molecule O=C([O-])c1ccc2c(c1)[N-]C1=NS(=O)(=O)N=C1N2.,O=C([O-])c1ccc2c(c1)[N-]C1=NS(=O)(=O)N=C1N2,amine
37626,Modify the molecule CC(C)n1c(S[C@@H](C)C(=O)NC2CC2)nnc1N(C)C by removing a amide.,CC(C)n1c(S[C@@H](C)C(=O)NC2CC2)nnc1N(C)C,amide
150207,Remove a amide from the molecule CCS(=O)(=O)c1cccc(C(=O)N(Cc2ccncc2)c2nc3cc(OC)ccc3s2)c1.,CCS(=O)(=O)c1cccc(C(=O)N(Cc2ccncc2)c2nc3cc(OC)ccc3s2)c1,amide
109777,Remove a benzene_ring from the molecule N#C/C(=C\c1ccco1)C(=O)Nc1ncc(Cc2ccc(F)cc2)s1.,N#C/C(=C\c1ccco1)C(=O)Nc1ncc(Cc2ccc(F)cc2)s1,benzene_ring
6034,Modify the molecule CC(C)CNC(=O)C[NH2+]C1C(C)(C)C1(C)C by removing a amide.,CC(C)CNC(=O)C[NH2+]C1C(C)(C)C1(C)C,amide
146076,Remove a hydroxyl from the molecule CCc1ccc([C@@H](O)[C@]2(C)CCCO2)s1.,CCc1ccc([C@@H](O)[C@]2(C)CCCO2)s1,hydroxyl
120971,Modify the molecule Cc1cc(CC(=O)N(Cc2ccc(C)o2)c2ccc(F)cc2)no1 by removing a benzene_ring.,Cc1cc(CC(=O)N(Cc2ccc(C)o2)c2ccc(F)cc2)no1,benzene_ring
106244,Please remove a amide from the molecule CO[C@@H]1C=C[C@@](CNC(=O)[C@@H]2CCCN(c3cc(-n4cccn4)ncn3)C2)(OC)O1.,CO[C@@H]1C=C[C@@](CNC(=O)[C@@H]2CCCN(c3cc(-n4cccn4)ncn3)C2)(OC)O1,amide
96704,Modify the molecule COc1ccc(Nc2nnc(S[C@H]3CC(=O)N(c4cccc(Cl)c4C)C3=O)s2)cc1 by removing a amine.,COc1ccc(Nc2nnc(S[C@H]3CC(=O)N(c4cccc(Cl)c4C)C3=O)s2)cc1,amine
9717,Please remove a halo from the molecule O=C(Nc1ccccc1F)c1ccc(S(=O)(=O)N[C@H]2CC[NH2+]C2)cc1.,O=C(Nc1ccccc1F)c1ccc(S(=O)(=O)N[C@H]2CC[NH2+]C2)cc1,halo
197671,Please remove a halo from the molecule CC[NH2+]C[C@@H](Cc1ccc(F)cc1)c1ccccc1F.,CC[NH2+]C[C@@H](Cc1ccc(F)cc1)c1ccccc1F,halo
206885,Please remove a nitro from the molecule Cc1c(NC(=O)[C@@H](C)Sc2nncs2)cccc1[N+](=O)[O-].,Cc1c(NC(=O)[C@@H](C)Sc2nncs2)cccc1[N+](=O)[O-],nitro
78436,Please remove a benzene_ring from the molecule CC[C@@H](C)N(C)C(=O)NCCc1csc(-c2ccccc2)n1.,CC[C@@H](C)N(C)C(=O)NCCc1csc(-c2ccccc2)n1,benzene_ring
134400,Remove a benzene_ring from the molecule CC(C)(C)c1nc(CCNC(=O)c2c(O)cccc2O)cs1.,CC(C)(C)c1nc(CCNC(=O)c2c(O)cccc2O)cs1,benzene_ring
111781,Remove a halo from the molecule Cc1ccc(F)cc1[C@@]1(O)CCCC1(C)C.,Cc1ccc(F)cc1[C@@]1(O)CCCC1(C)C,halo
180139,Modify the molecule COc1ccc(-c2nc(NC(=O)C3CCN(c4cnccn4)CC3)sc2C)cc1 by removing a amide.,COc1ccc(-c2nc(NC(=O)C3CCN(c4cnccn4)CC3)sc2C)cc1,amide
49291,Remove a amine from the molecule O=S(=O)(NCc1nnnn1-c1ccc(F)c(F)c1)c1cccc(C(F)(F)F)c1.,O=S(=O)(NCc1nnnn1-c1ccc(F)c(F)c1)c1cccc(C(F)(F)F)c1,amine
78788,Please remove a nitro from the molecule COc1cccc([C@@H](CNC(=O)Nc2ccc([N+](=O)[O-])cc2)[NH+](C)C)c1.,COc1cccc([C@@H](CNC(=O)Nc2ccc([N+](=O)[O-])cc2)[NH+](C)C)c1,nitro
84062,Please remove a amide from the molecule CC(C)n1nccc1NC(=O)C(=O)N[C@@H]1CCCC[C@H]1OC1CCCC1.,CC(C)n1nccc1NC(=O)C(=O)N[C@@H]1CCCC[C@H]1OC1CCCC1,amide
147768,Modify the molecule CC(C)[NH+](Cc1ccc([N+](=O)[O-])cc1)CC1CC[NH2+]CC1 by removing a benzene_ring.,CC(C)[NH+](Cc1ccc([N+](=O)[O-])cc1)CC1CC[NH2+]CC1,benzene_ring
95180,Remove a benzene_ring from the molecule Cc1cc(F)c([C@@H]2C[S@@](=O)CC(C)(C)N2)cc1F.,Cc1cc(F)c([C@@H]2C[S@@](=O)CC(C)(C)N2)cc1F,benzene_ring
24980,Modify the molecule CCCN[C@@H](Cc1ccccc1Cl)C[NH+](C)C by removing a benzene_ring.,CCCN[C@@H](Cc1ccccc1Cl)C[NH+](C)C,benzene_ring
73090,Modify the molecule CC(C)(C)c1ccc(C(=O)Nc2ccccc2N2CCNC(=O)C2)cc1 by removing a amide.,CC(C)(C)c1ccc(C(=O)Nc2ccccc2N2CCNC(=O)C2)cc1,amide
66957,Please remove a halo from the molecule Cc1sc(C[NH3+])nc1-c1ccc(Cl)cc1Cl.,Cc1sc(C[NH3+])nc1-c1ccc(Cl)cc1Cl,halo
68750,Remove a amide from the molecule CC[C@H]1CCCCN1C(=O)[C@H](C)OC(=O)c1ccc2nc(C)c(C)nc2c1.,CC[C@H]1CCCCN1C(=O)[C@H](C)OC(=O)c1ccc2nc(C)c(C)nc2c1,amide
68112,Please remove a amine from the molecule CC(C)(C)C(=O)NC(=S)Nc1cccc(C(=O)N2CCCCC2)c1.,CC(C)(C)C(=O)NC(=S)Nc1cccc(C(=O)N2CCCCC2)c1,amine
131032,Please remove a amide from the molecule Cc1n[nH]c2ncc(C(=O)Nc3nnc(C4CC4)s3)cc12.,Cc1n[nH]c2ncc(C(=O)Nc3nnc(C4CC4)s3)cc12,amide
88178,Modify the molecule C[C@@H](NC(=O)Cn1c(C2CCCCC2)nc2ccccc21)C(N)=O by removing a amide.,C[C@@H](NC(=O)Cn1c(C2CCCCC2)nc2ccccc21)C(N)=O,amide
190959,Please remove a amide from the molecule Cc1n[nH]cc1CNC(=O)c1ccncc1C#CC[NH3+].,Cc1n[nH]cc1CNC(=O)c1ccncc1C#CC[NH3+],amide
5163,Remove a amide from the molecule CCO[C@@H]1C[C@H]1C(=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1.,CCO[C@@H]1C[C@H]1C(=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1,amide
196221,Please remove a benzene_ring from the molecule CSCC[C@@H](NC(=O)c1ccccc1Cl)C(=O)N[C@@]1(C)CCS(=O)(=O)C1.,CSCC[C@@H](NC(=O)c1ccccc1Cl)C(=O)N[C@@]1(C)CCS(=O)(=O)C1,benzene_ring
138474,Please remove a amide from the molecule Cc1ccc(O[C@H](C)C(=O)N/N=C/c2cccnc2)cc1.,Cc1ccc(O[C@H](C)C(=O)N/N=C/c2cccnc2)cc1,amide
19015,Please remove a halo from the molecule CCCc1ccc(C(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1.,CCCc1ccc(C(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1,halo
180868,Remove a benzene_ring from the molecule Cc1oc(-c2ccc(C(=O)NC3CCCC3)cc2)nc1C[S@@](=O)c1ccccc1.,Cc1oc(-c2ccc(C(=O)NC3CCCC3)cc2)nc1C[S@@](=O)c1ccccc1,benzene_ring
94544,Remove a amide from the molecule NC(=O)NC(=O)CSc1ncnc2sc3c(c12)CCCC3.,NC(=O)NC(=O)CSc1ncnc2sc3c(c12)CCCC3,amide
240671,Please remove a benzene_ring from the molecule C[C@H](Sc1ccccc1)c1nc(-c2cnccn2)no1.,C[C@H](Sc1ccccc1)c1nc(-c2cnccn2)no1,benzene_ring
188102,Modify the molecule CCOc1cccc(C(=O)Nc2nc(-c3ccccc3)ns2)c1 by removing a amide.,CCOc1cccc(C(=O)Nc2nc(-c3ccccc3)ns2)c1,amide
216569,Please remove a benzene_ring from the molecule CC(C)n1nccc1NC(=O)COc1cc(F)ccc1F.,CC(C)n1nccc1NC(=O)COc1cc(F)ccc1F,benzene_ring
176195,Remove a benzene_ring from the molecule CCOc1ccc(NC(=O)N[C@H](C)c2cnn(CC)c2C)cc1.,CCOc1ccc(NC(=O)N[C@H](C)c2cnn(CC)c2C)cc1,benzene_ring
183677,Modify the molecule C[NH2+][C@]1(C(=O)[O-])CCC[C@H](Oc2ccc(C)cc2)C1 by removing a benzene_ring.,C[NH2+][C@]1(C(=O)[O-])CCC[C@H](Oc2ccc(C)cc2)C1,benzene_ring
196687,Remove a benzene_ring from the molecule COc1ccc([C@H](CNC(=O)c2ccc(-n3cccc3)cc2)N2CCOCC2)cc1.,COc1ccc([C@H](CNC(=O)c2ccc(-n3cccc3)cc2)N2CCOCC2)cc1,benzene_ring
219290,Modify the molecule Cc1cccc2c(CCNC(=O)N(C)Cc3ccccc3O)c[nH]c12 by removing a benzene_ring.,Cc1cccc2c(CCNC(=O)N(C)Cc3ccccc3O)c[nH]c12,benzene_ring
186887,Modify the molecule C[C@@H](C(=O)N1CCc2ccccc2C1)[NH+]1CCC[C@H](O)C1 by removing a amide.,C[C@@H](C(=O)N1CCc2ccccc2C1)[NH+]1CCC[C@H](O)C1,amide
191341,Remove a amide from the molecule CCO[C@@H](C)c1noc(CN2CCN(C(=O)CC(F)(F)F)CC2)n1.,CCO[C@@H](C)c1noc(CN2CCN(C(=O)CC(F)(F)F)CC2)n1,amide
112066,Please remove a benzene_ring from the molecule COc1cccc(C(=O)/N=C(/[N-]Cc2cccnc2)Nc2ccc(Cl)cc2C)c1.,COc1cccc(C(=O)/N=C(/[N-]Cc2cccnc2)Nc2ccc(Cl)cc2C)c1,benzene_ring
203923,Please remove a amine from the molecule O=C(NC(=S)Nc1cccc(CO)c1)c1ccccc1[N+](=O)[O-].,O=C(NC(=S)Nc1cccc(CO)c1)c1ccccc1[N+](=O)[O-],amine
163942,Modify the molecule O=C(c1cccc(S(=O)(=O)Oc2ccc(Cl)cc2)c1)N1CCCC1 by removing a benzene_ring.,O=C(c1cccc(S(=O)(=O)Oc2ccc(Cl)cc2)c1)N1CCCC1,benzene_ring
38540,Please remove a benzene_ring from the molecule CCC(=O)N(C)c1ccccc1C(=O)NCC(=O)OC(C)(C)C.,CCC(=O)N(C)c1ccccc1C(=O)NCC(=O)OC(C)(C)C,benzene_ring
217086,Please remove a benzene_ring from the molecule O=Cc1cccc(OCc2cccc3ccccc23)c1.,O=Cc1cccc(OCc2cccc3ccccc23)c1,benzene_ring
31294,Please remove a amide from the molecule Cc1nsnc1COc1cccc(C(=O)N[C@@H]2CCS(=O)(=O)C2)c1.,Cc1nsnc1COc1cccc(C(=O)N[C@@H]2CCS(=O)(=O)C2)c1,amide
59246,Modify the molecule CCc1onc(C)c1NC(=O)N(Cc1ccc(Cl)c(Cl)c1)C1CC1 by removing a benzene_ring.,CCc1onc(C)c1NC(=O)N(Cc1ccc(Cl)c(Cl)c1)C1CC1,benzene_ring
17484,Remove a benzene_ring from the molecule CCN(C(=O)c1cc(C2CC2)n(C(C)(C)C)n1)c1ccc(F)c(F)c1.,CCN(C(=O)c1cc(C2CC2)n(C(C)(C)C)n1)c1ccc(F)c(F)c1,benzene_ring
153060,Please remove a amide from the molecule C[C@@H](OC(=O)c1ccc2c(c1)CCC(=O)N2)C(=O)Nc1ccc(Cl)cn1.,C[C@@H](OC(=O)c1ccc2c(c1)CCC(=O)N2)C(=O)Nc1ccc(Cl)cn1,amide
19390,Remove a benzene_ring from the molecule COc1c(C)cccc1C1=N/C(=C\c2ccc([N+](=O)[O-])cc2)C(=O)O1.,COc1c(C)cccc1C1=N/C(=C\c2ccc([N+](=O)[O-])cc2)C(=O)O1,benzene_ring
237517,Remove a benzene_ring from the molecule CCN(C(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)c1ccccc1.,CCN(C(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)c1ccccc1,benzene_ring
8470,Please remove a benzene_ring from the molecule C[NH+]1CCC(N(Cc2ccco2)C(=S)Nc2cc(Cl)ccc2C(F)(F)F)CC1.,C[NH+]1CCC(N(Cc2ccco2)C(=S)Nc2cc(Cl)ccc2C(F)(F)F)CC1,benzene_ring
80717,Remove a benzene_ring from the molecule CCOc1ccc([C@H](C)[NH2+]CC(C)(C)N2CCS(=O)CC2)cc1.,CCOc1ccc([C@H](C)[NH2+]CC(C)(C)N2CCS(=O)CC2)cc1,benzene_ring
147498,Modify the molecule COc1ccc(OC)c(CCC(=O)Nc2cccc(-c3n[nH]c(C)n3)c2)c1 by removing a benzene_ring.,COc1ccc(OC)c(CCC(=O)Nc2cccc(-c3n[nH]c(C)n3)c2)c1,benzene_ring
99405,Remove a amide from the molecule CC(C)CC(C)(C)C(=O)NC1CCN(c2ccccc2)CC1.,CC(C)CC(C)(C)C(=O)NC1CCN(c2ccccc2)CC1,amide
155066,Please remove a halo from the molecule O=C(COC(=O)c1ccco1)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1Cl.,O=C(COC(=O)c1ccco1)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1Cl,halo
29606,Remove a benzene_ring from the molecule Nc1cccc(C(=O)/C=C/c2ccccc2)c1.,Nc1cccc(C(=O)/C=C/c2ccccc2)c1,benzene_ring
221152,Modify the molecule C[C@@H]1C[C@@H](C)C[NH+](CCNC(=O)NCc2ccccc2F)C1 by removing a halo.,C[C@@H]1C[C@@H](C)C[NH+](CCNC(=O)NCc2ccccc2F)C1,halo
232163,Please remove a benzene_ring from the molecule CC(=O)N1CC[C@@H](NC(=O)NCc2ccc(N3CC[NH+](CC4CC4)CC3)cc2)C1.,CC(=O)N1CC[C@@H](NC(=O)NCc2ccc(N3CC[NH+](CC4CC4)CC3)cc2)C1,benzene_ring
220152,Please remove a amide from the molecule COC(=O)[C@H](CC(C)C)NC(=O)c1cnc2ccc(C)cn12.,COC(=O)[C@H](CC(C)C)NC(=O)c1cnc2ccc(C)cn12,amide
235590,Modify the molecule Cc1cc(C)cc(NC(=O)c2ccc(Cl)c(N)c2)c1 by removing a amine.,Cc1cc(C)cc(NC(=O)c2ccc(Cl)c(N)c2)c1,amine
66874,Please remove a benzene_ring from the molecule CN(C)S(=O)(=O)c1cccc(C(=O)NNC(=O)CC2CCCC2)c1.,CN(C)S(=O)(=O)c1cccc(C(=O)NNC(=O)CC2CCCC2)c1,benzene_ring
57681,Remove a nitro from the molecule Nc1ccc(C(=O)Nc2ccccc2SC(F)F)cc1[N+](=O)[O-].,Nc1ccc(C(=O)Nc2ccccc2SC(F)F)cc1[N+](=O)[O-],nitro
118391,Please remove a amide from the molecule CC1(C)Cc2c(sc(NC(=O)C(=O)NC[C@@H]3CCCO3)c2C(N)=O)CO1.,CC1(C)Cc2c(sc(NC(=O)C(=O)NC[C@@H]3CCCO3)c2C(N)=O)CO1,amide
209027,Please remove a halo from the molecule O=[N+]([O-])[C@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1ccc(Cl)s1.,O=[N+]([O-])[C@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1ccc(Cl)s1,halo
79306,Please remove a amine from the molecule O=S(=O)(NC[C@H](c1cccs1)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(F)cc1.,O=S(=O)(NC[C@H](c1cccs1)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(F)cc1,amine
92669,Remove a benzene_ring from the molecule CCc1nnc(NC(=O)NCc2cccc(C[NH+](C)C)c2)s1.,CCc1nnc(NC(=O)NCc2cccc(C[NH+](C)C)c2)s1,benzene_ring
148157,Remove a amide from the molecule CC[C@H](Sc1nncn1C(C)(C)C)C(=O)NCc1ccccc1.,CC[C@H](Sc1nncn1C(C)(C)C)C(=O)NCc1ccccc1,amide
61749,Please remove a amide from the molecule Cc1nnc(S[C@H](C)C(=O)N(C)c2ccccc2)n1-c1ccccc1.,Cc1nnc(S[C@H](C)C(=O)N(C)c2ccccc2)n1-c1ccccc1,amide
233334,Please remove a benzene_ring from the molecule O=C(NCc1nccc2ccccc12)c1c(Cl)cccc1Cl.,O=C(NCc1nccc2ccccc12)c1c(Cl)cccc1Cl,benzene_ring
115375,Modify the molecule CCc1ccc(C2=CCN(C(=O)c3ccc(Cl)nc3)CC2)cc1 by removing a amide.,CCc1ccc(C2=CCN(C(=O)c3ccc(Cl)nc3)CC2)cc1,amide
37078,Please remove a amide from the molecule COc1ccnc(N2CCc3c(cccc3NC(C)=O)C2)n1.,COc1ccnc(N2CCc3c(cccc3NC(C)=O)C2)n1,amide
8175,Modify the molecule CC(=O)N1CCC([C@H]2CC=CCN(Cc3ccccc3)C2=O)CC1 by removing a benzene_ring.,CC(=O)N1CCC([C@H]2CC=CCN(Cc3ccccc3)C2=O)CC1,benzene_ring
171564,Remove a amide from the molecule C=CCO[C@H](C)C(=O)Oc1ccc2c(c1)CCC(=O)N2.,C=CCO[C@H](C)C(=O)Oc1ccc2c(c1)CCC(=O)N2,amide
4959,Remove a halo from the molecule C[C@H]1CC(Oc2c(F)cc(CC[NH3+])cc2F)C[C@H](C)C1.,C[C@H]1CC(Oc2c(F)cc(CC[NH3+])cc2F)C[C@H](C)C1,halo
185293,Remove a amide from the molecule O=C(c1cnccn1)N(Cc1ccc2c(c1)OCO2)C1CCCC1.,O=C(c1cnccn1)N(Cc1ccc2c(c1)OCO2)C1CCCC1,amide
8189,Please remove a halo from the molecule C[C@@H]1CC[C@H](NC(=O)Nc2cc(C(=O)N(C)C)ccc2F)[C@H](C)C1.,C[C@@H]1CC[C@H](NC(=O)Nc2cc(C(=O)N(C)C)ccc2F)[C@H](C)C1,halo
111176,Please remove a amine from the molecule Cc1ccc(S(=O)(=O)Nc2ccccc2N2CCCC2)cc1[N+](=O)[O-].,Cc1ccc(S(=O)(=O)Nc2ccccc2N2CCCC2)cc1[N+](=O)[O-],amine
163205,Remove a hydroxyl from the molecule CCOc1ccc(NC(=O)N(C)CC[C@@H](C)O)cc1OC.,CCOc1ccc(NC(=O)N(C)CC[C@@H](C)O)cc1OC,hydroxyl
130918,Please remove a amide from the molecule O=C(Nc1cccc(C(=O)Nc2nccs2)c1)c1ccc2c(c1)C(=O)N(C[C@@H]1CCCO1)C2=O.,O=C(Nc1cccc(C(=O)Nc2nccs2)c1)c1ccc2c(c1)C(=O)N(C[C@@H]1CCCO1)C2=O,amide
80901,Please remove a amide from the molecule COc1ccc([C@@H](OC)[C@@H](C)NC(=O)c2sc(C(C)C)nc2C)cc1.,COc1ccc([C@@H](OC)[C@@H](C)NC(=O)c2sc(C(C)C)nc2C)cc1,amide
119108,Modify the molecule C[C@H](NC(=O)NC[C@@H](c1ccco1)[NH+](C)C)c1ccc(C(F)(F)F)cc1 by removing a halo.,C[C@H](NC(=O)NC[C@@H](c1ccco1)[NH+](C)C)c1ccc(C(F)(F)F)cc1,halo
127321,Remove a benzene_ring from the molecule CN(C(=O)COCCOc1ccccc1)c1cccc2ncccc12.,CN(C(=O)COCCOc1ccccc1)c1cccc2ncccc12,benzene_ring
245840,Please remove a benzene_ring from the molecule Cc1ccccc1Cc1noc(CN2CCC[C@@H](C[NH+]3CCCC[C@@H]3C)C2)n1.,Cc1ccccc1Cc1noc(CN2CCC[C@@H](C[NH+]3CCCC[C@@H]3C)C2)n1,benzene_ring
148288,Remove a benzene_ring from the molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@@H](c1ccccc1)c1ccco1.,COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@@H](c1ccccc1)c1ccco1,benzene_ring
230991,Modify the molecule C[C@H]1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)[C@@H](C)C1 by removing a amide.,C[C@H]1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)[C@@H](C)C1,amide
75352,Remove a amide from the molecule Cc1cccc(C(=O)N2CCC[C@H](Nc3ccc(F)cc3)C2)c1.,Cc1cccc(C(=O)N2CCC[C@H](Nc3ccc(F)cc3)C2)c1,amide
50681,Please remove a amide from the molecule COc1ccc2[nH]cc(C(=O)N[C@@H](C(=O)Nc3ccc(C)cc3)c3ccccc3)c2n1.,COc1ccc2[nH]cc(C(=O)N[C@@H](C(=O)Nc3ccc(C)cc3)c3ccccc3)c2n1,amide
205363,Please remove a benzene_ring from the molecule CN(CCO)C(=O)C[C@H]1C(=O)NCCN1Cc1ccc(F)c(F)c1.,CN(CCO)C(=O)C[C@H]1C(=O)NCCN1Cc1ccc(F)c(F)c1,benzene_ring
175432,Modify the molecule CCCCOC(=O)c1cccc([N+](=O)[O-])c1C by removing a benzene_ring.,CCCCOC(=O)c1cccc([N+](=O)[O-])c1C,benzene_ring
85844,Modify the molecule Cc1nc2c(cnn2C(C)C)cc1C(=O)N1CCC[C@H](c2[nH]cc[nH+]2)C1 by removing a amide.,Cc1nc2c(cnn2C(C)C)cc1C(=O)N1CCC[C@H](c2[nH]cc[nH+]2)C1,amide
60204,Please remove a hydroxyl from the molecule Cc1cc([C@@H](C)NC(=O)CCCCO)c(C)s1.,Cc1cc([C@@H](C)NC(=O)CCCCO)c(C)s1,hydroxyl
92585,Please remove a amide from the molecule Cc1cccc(NC(=O)Cn2ncccc2=O)c1.,Cc1cccc(NC(=O)Cn2ncccc2=O)c1,amide
213680,Please remove a benzene_ring from the molecule Cn1cc(COC(=O)/C=C/c2ccccc2OC(F)(F)F)cn1.,Cn1cc(COC(=O)/C=C/c2ccccc2OC(F)(F)F)cn1,benzene_ring
136356,Remove a amide from the molecule Cc1ccc(CCCC(=O)NCc2nc(-c3ccncc3)no2)s1.,Cc1ccc(CCCC(=O)NCc2nc(-c3ccncc3)no2)s1,amide
109610,Please remove a hydroxyl from the molecule O=C(NC[C@@H]1CC[C@H](C(=O)[O-])O1)c1ccc(CO)cc1.,O=C(NC[C@@H]1CC[C@H](C(=O)[O-])O1)c1ccc(CO)cc1,hydroxyl
217490,Modify the molecule CC(=O)Oc1cccc(/C=C(\C#N)C(=O)Nc2ccc(Cl)cc2[N+](=O)[O-])c1 by removing a nitro.,CC(=O)Oc1cccc(/C=C(\C#N)C(=O)Nc2ccc(Cl)cc2[N+](=O)[O-])c1,nitro
229756,Remove a benzene_ring from the molecule O=NNc1nc2ccccc2n1Cc1ccccc1.,O=NNc1nc2ccccc2n1Cc1ccccc1,benzene_ring
237014,Remove a amide from the molecule Cc1n[nH]c(-c2ccc(NC(=O)CCC(C)C)cc2)n1.,Cc1n[nH]c(-c2ccc(NC(=O)CCC(C)C)cc2)n1,amide
99567,Please remove a nitro from the molecule CNc1ncnc(NC[C@H]2CCCO2)c1[N+](=O)[O-].,CNc1ncnc(NC[C@H]2CCCO2)c1[N+](=O)[O-],nitro
215495,Remove a amide from the molecule CCCCn1nc(C(=O)N2CCC(C(=O)c3ccc4c(c3)OCCO4)CC2)c2ccccc2c1=O.,CCCCn1nc(C(=O)N2CCC(C(=O)c3ccc4c(c3)OCCO4)CC2)c2ccccc2c1=O,amide
103396,Modify the molecule O=[N+]([O-])c1ccc(-c2nc(=S)c3c(n2-c2ccccc2)CCCC3)cc1 by removing a nitro.,O=[N+]([O-])c1ccc(-c2nc(=S)c3c(n2-c2ccccc2)CCCC3)cc1,nitro
209214,Please remove a benzene_ring from the molecule Cc1ccc(-c2nc(C[NH2+]C3CCN(c4cccc(C)[nH+]4)CC3)co2)cc1.,Cc1ccc(-c2nc(C[NH2+]C3CCN(c4cccc(C)[nH+]4)CC3)co2)cc1,benzene_ring
189757,Please remove a halo from the molecule COc1ccc([C@@H]2CN(C(=O)c3cccc(Cl)c3)C[C@H]2C(=O)NCCC(C)C)cc1.,COc1ccc([C@@H]2CN(C(=O)c3cccc(Cl)c3)C[C@H]2C(=O)NCCC(C)C)cc1,halo
151632,Please remove a halo from the molecule O=C(Cc1ccncc1)N1CCC[C@H](c2cccc(Cc3ccccc3F)n2)C1.,O=C(Cc1ccncc1)N1CCC[C@H](c2cccc(Cc3ccccc3F)n2)C1,halo
63729,Remove a benzene_ring from the molecule COc1ccc(/C=C2\Oc3c(CN4CCOCC4)c(O)cc(C)c3C2=O)c(OC)c1.,COc1ccc(/C=C2\Oc3c(CN4CCOCC4)c(O)cc(C)c3C2=O)c(OC)c1,benzene_ring
131873,Remove a hydroxyl from the molecule CCOCCSc1nc([O-])c2cnn(CCO)c2n1.,CCOCCSc1nc([O-])c2cnn(CCO)c2n1,hydroxyl
149290,Please remove a amide from the molecule O=C(N/N=C/c1ccccc1F)c1cncc(Br)c1.,O=C(N/N=C/c1ccccc1F)c1cncc(Br)c1,amide
77383,Remove a hydroxyl from the molecule COc1ccc2c(c1)c(C(=O)N/N=C/c1ccc(O)c(O)c1)c(C)n2C.,COc1ccc2c(c1)c(C(=O)N/N=C/c1ccc(O)c(O)c1)c(C)n2C,hydroxyl
131395,Please remove a benzene_ring from the molecule COc1cc(/C=N/NC(=O)c2cc(Cl)ccc2O)ccc1OCC(=O)[O-].,COc1cc(/C=N/NC(=O)c2cc(Cl)ccc2O)ccc1OCC(=O)[O-],benzene_ring
96641,Please remove a amide from the molecule C[C@](O)(CNC(=O)c1n[nH]c2ccccc12)c1ccsc1.,C[C@](O)(CNC(=O)c1n[nH]c2ccccc12)c1ccsc1,amide
201743,Please remove a amide from the molecule COCC(=O)N[C@H](C)c1nc2ccccc2[nH]1.,COCC(=O)N[C@H](C)c1nc2ccccc2[nH]1,amide
39688,Please remove a benzene_ring from the molecule CCCNC(=O)[C@@H](C)S(=O)(=O)Cc1cc(-c2ccccc2)on1.,CCCNC(=O)[C@@H](C)S(=O)(=O)Cc1cc(-c2ccccc2)on1,benzene_ring
217104,Please remove a amide from the molecule CC(=O)c1cc2c(cc1NC(=O)CCC(C)C)OCO2.,CC(=O)c1cc2c(cc1NC(=O)CCC(C)C)OCO2,amide
138476,Remove a benzene_ring from the molecule N#C[C@@H](c1ccccc1)[C@@H]1CCCN1c1ccc([N+](=O)[O-])cc1.,N#C[C@@H](c1ccccc1)[C@@H]1CCCN1c1ccc([N+](=O)[O-])cc1,benzene_ring
53134,Please remove a benzene_ring from the molecule COCCn1ccc2ccc(NC(=O)[C@H](C)c3ccc(OC)cc3)cc21.,COCCn1ccc2ccc(NC(=O)[C@H](C)c3ccc(OC)cc3)cc21,benzene_ring