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# **GPepT: A Language Model for Peptides and Peptidomimetics**
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GPepT is a cutting-edge language model designed to understand and generate sequences in the specialized domain of peptides and peptidomimetics. It serves as a powerful tool for _de novo_ protein design and engineering. As demonstrated in our research, the incorporation of peptidomimetics significantly broadens the chemical space accessible through generated sequences, enabling innovative approaches to peptide-based therapeutics.
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## **Model Overview**
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GPepT builds upon the GPT-2 Transformer architecture, comprising 36 layers and a model dimensionality of 1280, with a total of 738 million parameters. This decoder-only model has been pre-trained on a curated dataset of peptides and peptidomimetics mined from bioactivity-labeled chemical formulas in ChEMBL.
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To leverage GPepT’s pre-trained weights, input molecules must be converted into a standardized sequence-like representation of peptidomimetics using **Monomerizer**
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Unlike traditional protein design models, GPepT is trained in a self-supervised manner, using raw sequence data without explicit annotation. This design enables the model to generalize across diverse sequence spaces, producing functional antimicrobial peptidomimetics upon fine-tuning.
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# **GPepT: A Language Model for Peptides and Peptidomimetics**
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GPepT is a cutting-edge language model designed to understand and generate sequences in the specialized domain of peptides and peptidomimetics. It serves as a powerful tool for _de novo_ protein design and engineering. As demonstrated in our research, the incorporation of peptidomimetics significantly broadens the chemical space accessible through generated sequences, enabling innovative approaches to peptide-based therapeutics.
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## **Model Overview**
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GPepT builds upon the GPT-2 Transformer architecture, comprising 36 layers and a model dimensionality of 1280, with a total of 738 million parameters. This decoder-only model has been pre-trained on a curated dataset of peptides and peptidomimetics mined from bioactivity-labeled chemical formulas in ChEMBL.
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To leverage GPepT’s pre-trained weights, input molecules must be converted into a standardized sequence-like representation of peptidomimetics using [**Monomerizer**](https://github.com/tsudalab/Monomerizer/tree/main). Detailed insights into the training process and datasets are provided in our accompanying publication.
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Unlike traditional protein design models, GPepT is trained in a self-supervised manner, using raw sequence data without explicit annotation. This design enables the model to generalize across diverse sequence spaces, producing functional antimicrobial peptidomimetics upon fine-tuning.
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