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This
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<p align="center"> <b> Predictive Radiomics for Evaluation of Cancer Immune SignaturE in Glioblastoma | PRECISE-GBM </b> </p>
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<p align="center">
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<img src="PRECISE-GBM_GUI_logo%20(1).png" alt="PRECISE-GBM Logo">
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</p>
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<b> Project: PRECISE-GBM - Model training & retraining helpers </b>
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Overview
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This repository contains code to train models (Gaussian Mixture labelling + SVM and ensemble classifiers) and to persist all artifacts required to reproduce or retrain models on new data. It includes:
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- `Scenario_heldout_final_PRECISE.py` β training pipeline producing `.joblib` models and metadata JSONs (selected features, best params, CV results).
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- `retrain_helper.py` β CLI utility to rebuild pipelines, set best params and retrain using saved selected-features and params JSONs. Supports JSON/YAML config files and auto-detection of model type.
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- `README_RETRAIN.md` β detailed retrain examples and a notebook cell.
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This repo also includes helper files to make it ready for GitHub:
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- `requirements.txt` β Python dependencies
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- `.gitignore` β recommended ignores (models, caches, logs)
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- `LICENSE` β MIT license
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- GitHub Actions workflow for CI (pytest smoke test)
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Getting started (Windows PowerShell)
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1) Create and activate a virtual environment
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```powershell
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python -m venv .venv
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.\.venv\Scripts\Activate.ps1
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```
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2) Install dependencies
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```powershell
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pip install --upgrade pip
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pip install -r requirements.txt
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```
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3) Run training (note: the training script reads data from absolute paths configured in the script β adjust them or run from an environment where those files are present)
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```powershell
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python Scenario_heldout_final_PRECISE.py
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```
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The training script will create model files under `models_LM22/` and `models_GBM/` and write metadata JSONs next to each joblib model (selected features, params, cv results) as well as group-level JSON summaries.
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Retraining
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See `README_RETRAIN.md` for detailed CLI and notebook examples. Short example:
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```powershell
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python retrain_helper.py \
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--model-prefix "models_GBM/scenario_1/GBM_scen1_Tcell" \
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--train-csv "data\new_train.csv" \
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--label-col "label"
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```
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Notes
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- The training script contains hard-coded absolute paths to data files. Before running on another machine, update the `scenarios_*` file paths or place the datasets in the same paths.
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- Retrain helper auto-detects model type when `--model-type` is omitted by looking for `{prefix}_svm_params.json` or `{prefix}_ens_params.json`.
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- YAML config support for retrain requires PyYAML (`pip install pyyaml`).
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CI
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A basic GitHub Actions workflow runs a smoke pytest to ensure the retrain helper imports and basic pipeline construction works. It does not run heavy training.
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Contributing
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See `CONTRIBUTING.md` for guidance on opening issues and PRs.
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License
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This project is released under the MIT License β see `LICENSE`.
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Citation:
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Please use the following citation when using the repository.
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2025
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β’ Ghimire P, Modat M, Booth T. Predictive radiogenomic AI Model for patient stratification in brain tumor immunotherapy trials. Neuro-oncology. Oct 2025; 26(Suppl_3): iii58βiii59. https://doi.org/10.1093/neuonc/noaf193.188
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β’ Ghimire P, Modat M, Booth T. Radiogenomic AI model predicts immune status in IDH wildtype glioblastoma: PRECISE-GBM study. RCR open. Jan 2025; 3(1): 100234
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2024
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β’ Ghimire P, Modat M, Booth T. A machine Learning bases predictive radiomics for evaluation of cancer immune signature in glioblastoma: the PRECISE-GBM study. Neuro-Oncology. Oct 2024; 26(suppl_5): v25.
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β’ Ghimire P, Modat M, Booth T. A radiogenomic machine learning based study to identify Predictive Radiomics for Evaluation of Cancer Immune SignaturE in IDHw Glioblastoma. Neuro-Oncology. Oct 2024; 26(suppl_7): vii3
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