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---
license: agpl-3.0
tags:
  - rare-disease
  - world-model
  - diffusion-forcing
  - clinical-ai
  - patient-digital-twin
---

# GEMEO Architecture (Reference)

This HuggingFace repository is a **discoverability mirror** for the GEMEO
reference architecture, which is maintained on GitHub:

**Code (AGPL-3.0):** https://github.com/rarasAI/gemeo
**Model weights (CC-BY-NC-4.0):** https://huggingface.co/Raras-AI/gemeo-sus
**Benchmark (CC-BY-NC-4.0):** https://huggingface.co/datasets/Raras-AI/rarebench-br-trajectory
**Paper (DOI, always-latest):** https://doi.org/10.5281/zenodo.20092130

## What GEMEO is

The first world-model architecture for rare disease: a three-pillar pipeline
(**Propose -> Simulate -> Verify**) that grounds onset candidates in the genome
and a biomedical knowledge graph, simulates patient trajectories with a
recurrence-aware Causal Diffusion Forcing transformer, and adjudicates every
prediction with an agentic differential-diagnosis agent (traceable evidence
path per decision).

## License

- **Code / reference implementation:** AGPL-3.0 (open-core). Commercial
  licenses available: dimas@raras.ai.
- **Trained weights (`gemeo-sus`) and benchmark:** CC-BY-NC-4.0.

## How to use

Clone the GitHub repo and follow `ADAPTING_TO_A_NEW_DATABASE.md`:

```bash
git clone https://github.com/rarasAI/gemeo
```

Research preview, not a medical device.