"""Gemeo as LLM context — bidirectional pipe between space and the LLM.

Three responsibilities:
  1. **serialize_twin_for_llm(twin)** — produce a compact, token-budgeted
     structured block (Markdown) summarising the twin: top dx, key risks,
     phenotypes, genes, drugs in use, DDI alerts, PCDT gaps, next questions.
     This block is what the LLM sees on every call for this case.

  2. **inject_context(case_id, system_prompt)** — wrapper used by every
     LLM call in the swarm. Looks up the cached twin (or builds it lazily),
     prepends the structured block to the system prompt under a "## Gemeo
     Digital — contexto do paciente" header. Token budget enforced.

  3. **absorb_message(case_id, message_text)** — when an LLM agent or a
     user adds new clinical content (lab, HPO, gene, treatment), this
     extracts structured items and feeds them back via `evolve_gemeo`,
     so the next LLM call sees the updated twin.

This is the "GraphRAG of the patient" — context is grounded in a graph
that itself updates from every conversational turn.
"""
from __future__ import annotations
import logging
import re
from typing import Optional

logger = logging.getLogger("gemeo.llm_context")

# Token budget (rough char count; ~4 chars per token).
DEFAULT_MAX_CHARS = 4000


def _section(title: str, body: str) -> str:
    body = body.strip()
    if not body:
        return ""
    return f"### {title}\n{body}\n"


def serialize_twin_for_llm(twin, *, max_chars: int = DEFAULT_MAX_CHARS) -> str:
    """Compact Markdown representation of the digital twin for LLM consumption."""
    if twin is None:
        return ""

    parts: list[str] = []
    parts.append(f"_Twin {twin.id} · case {twin.case_id} · embedding {twin.embedding_dim}d_")

    # diagnoses
    if twin.diagnoses:
        lines = []
        for d in twin.diagnoses[:5]:
            p = d.get("probability") or 0
            name = d.get("disease") or d.get("name") or "?"
            orpha = d.get("orpha") or "?"
            lines.append(f"- {name} (ORPHA:{orpha}) — p={p:.2f}, status={d.get('status', 'active')}")
        parts.append(_section("Diferencial", "\n".join(lines)))

    # snapshot summary (n_phenotypes etc.)
    parts.append(_section(
        "Snapshot",
        f"- Fenótipos: {twin.n_phenotypes}\n- Genes: {twin.n_genes}\n- Labs: {twin.n_labs}\n- Versões snapshot: {len(twin.snapshot_versions or [])}",
    ))

    # risk
    if twin.risk:
        r = twin.risk
        parts.append(_section(
            "Risco",
            f"- Severidade: {r.overall_severity:.2f}\n- Progressão: {r.progression_risk:.2f}\n- Urgência tx: {r.treatment_urgency:.2f}",
        ))

    # trajectory horizons (state at 6/12/24 months)
    if twin.trajectory and twin.trajectory.horizons:
        lines = []
        for h in twin.trajectory.horizons[:3]:
            lines.append(f"- T+{h.months}m (risco {h.risk_score:.2f}): {h.state[:160]}")
        parts.append(_section("Trajetória", "\n".join(lines)))

    # cohort centroid
    if twin.cohort and twin.cohort.centroid_disease:
        c = twin.cohort.centroid_disease
        parts.append(_section(
            "Coorte",
            f"- Centróide: {c['name']} ({c.get('count', 0)} pacientes, {round(c.get('fraction', 0) * 100)}%)\n- Membros: {len(twin.cohort.members or [])}",
        ))

    # drug candidates with SUS
    if twin.drugs and twin.drugs.candidates:
        lines = []
        for d in twin.drugs.candidates[:5]:
            tags = []
            if d.get("sus_dispensed"): tags.append("SUS")
            elif d.get("sus_in_pcdt"): tags.append("PCDT")
            tag = f" [{', '.join(tags)}]" if tags else ""
            lines.append(f"- {d.get('name', '?')}{tag} — {d.get('mechanism', '')[:80]}")
        parts.append(_section("Reposicionamento", "\n".join(lines)))

    # DDI alerts (only if any)
    if twin.ddi and twin.ddi.pairs:
        lines = []
        for p in twin.ddi.pairs[:5]:
            lines.append(f"- [{p.severity}] {p.drug_a} ↔ {p.drug_b}: {p.mechanism[:120]}")
        parts.append(_section(f"DDI (regime: {twin.ddi.regimen_risk})", "\n".join(lines)))

    # pharmacogen actionable
    if twin.pharmacogen and twin.pharmacogen.assessments:
        actionable = [a for a in twin.pharmacogen.assessments if a.cpic_level in ("A", "B")][:5]
        if actionable:
            lines = [
                f"- {a.gene}{f' {a.variant}' if a.variant else ''} × {a.drug} (CPIC {a.cpic_level}): {a.recommendation[:120]}"
                for a in actionable
            ]
            parts.append(_section("Farmacogenômica (acionável)", "\n".join(lines)))

    # family / pedigree
    if twin.family:
        f = twin.family
        rels = ", ".join(f"{r.relation} {round(r.recurrence_risk*100)}%" for r in (f.relatives or [])[:3])
        if rels:
            parts.append(_section("Pedigree", f"- Modo: {f.inheritance_mode}\n- Recorrência: {rels}"))

    # PCDT compliance
    if twin.protocol_compliance and twin.protocol_compliance.gaps:
        pc = twin.protocol_compliance
        gap_lines = [f"- [{g.priority}] {g.expected}" for g in pc.gaps[:5]]
        parts.append(_section(
            f"PCDT compliance ({round(pc.score * 100)}%)",
            "\n".join(gap_lines) if gap_lines else "Sem gaps.",
        ))

    # reverse phenotyping suggestions
    if twin.reverse_pheno and twin.reverse_pheno.items:
        lines = [f"- {it.name} ({it.hpo_id}, freq {round(it.expected_frequency*100)}%)" for it in twin.reverse_pheno.items[:5]]
        parts.append(_section("O que ainda procurar", "\n".join(lines)))

    # next questions
    if twin.next_questions:
        lines = [
            f"- {q.name} ({q.hpo_id}) — gain {q.information_gain:.2f} bits"
            + (" [PCDT]" if q.asks_in_pcdt else "")
            for q in twin.next_questions[:5]
        ]
        parts.append(_section("Próximas perguntas (info-gain)", "\n".join(lines)))

    # SUS grounding
    if twin.sus_check:
        s = twin.sus_check
        sus_lines = []
        if s.has_pcdt:
            sus_lines.append(f"- PCDT: sim ({s.pcdt_url or '—'})")
            if s.therapy_pcdt_recommended:
                sus_lines.append("- Terapias: " + ", ".join(s.therapy_pcdt_recommended[:5]))
        if s.nearest_centro:
            c = s.nearest_centro
            sus_lines.append(f"- Centro mais próximo: {c.get('nome')} ({c.get('cidade')}/{c.get('uf')})")
        if sus_lines:
            parts.append(_section("SUS", "\n".join(sus_lines)))

    out = "\n".join(p for p in parts if p)
    if len(out) > max_chars:
        out = out[: max_chars - 40].rstrip() + "\n\n…(twin truncado por orçamento de tokens)"
    return out


# ─── Inject into a system prompt ───────────────────────────────────────────

GEMEO_HEADER = "## Gêmeo Digital — contexto vivo do paciente"

GEMEO_INSTRUCTIONS = (
    "Use o gêmeo abaixo para fundamentar TODA recomendação. Quando precisar "
    "de evidência específica, chame a tool `gemeo_lookup(query)` para "
    "recuperar subgrafo + coorte + literatura ancorados no caso. Nunca "
    "invente fatos não presentes no gêmeo ou no resultado da lookup."
)


# ─── Adaptive (Self-RAG style) brief context — ~300 tokens ────────────────

def serialize_twin_brief(twin) -> str:
    """Compact ~300-token summary used for adaptive injection.

    Strategy: only top-3 dx + risk + SUS-aware drug + count of interesting
    secondary signals (DDI, pgx, family) so the LLM knows MORE is available.
    The model then calls `gemeo_lookup(query)` or `gemeo_state(section)`
    to dive in only when needed.
    """
    if twin is None:
        return ""
    lines: list[str] = [f"_Gemeo {twin.id} · {twin.embedding_dim}d_"]
    if twin.diagnoses:
        top3 = ", ".join(
            f"{d.get('name', d.get('disease', '?'))} (ORPHA:{d.get('orpha', '?')}, p={d.get('probability', 0):.2f})"
            for d in twin.diagnoses[:3]
        )
        lines.append(f"Top-dx: {top3}")
    if twin.risk:
        r = twin.risk
        lines.append(
            f"Risco: severidade={r.overall_severity:.2f} · progressão={r.progression_risk:.2f} · urgência={r.treatment_urgency:.2f}"
        )
    if twin.drugs and twin.drugs.candidates:
        sus_drug = next((d for d in twin.drugs.candidates if d.get("sus_dispensed")), None)
        if sus_drug:
            lines.append(f"SUS dispensa: {sus_drug.get('name')} ({sus_drug.get('mechanism', '')[:60]})")
    if twin.sus_check and twin.sus_check.has_pcdt:
        lines.append("PCDT: vigente; chame `gemeo_state(\"sus_check\")` para detalhes")
    # Pointer to deeper sections
    extras = []
    if twin.ddi and twin.ddi.pairs: extras.append(f"DDI({len(twin.ddi.pairs)})")
    if twin.pharmacogen and twin.pharmacogen.n_actionable: extras.append(f"PGx({twin.pharmacogen.n_actionable})")
    if twin.family: extras.append(f"Pedigree({twin.family.inheritance_mode})")
    if twin.cohort and twin.cohort.members: extras.append(f"Cohort({len(twin.cohort.members)})")
    if twin.next_questions: extras.append(f"Perguntas({len(twin.next_questions)})")
    if extras:
        lines.append(
            "Mais: " + " · ".join(extras) +
            ". Chame `gemeo_state(<section>)` ou `gemeo_lookup(<query>)` para acessar."
        )
    return "\n".join(lines)


GEMEO_BRIEF_HEADER = "## Gêmeo Digital (resumo)"
GEMEO_BRIEF_INSTRUCTIONS = (
    "Resumo abaixo. Tools disponíveis: `gemeo_lookup(query, mode='local'|'global')` "
    "para evidência grounded em subgrafo+coorte+literatura, e "
    "`gemeo_state(section)` para uma das capabilities específicas. "
    "Não invente fatos fora do gêmeo / das tools."
)


async def inject_context(
    case_id: str,
    system_prompt: str,
    *,
    max_chars: int = DEFAULT_MAX_CHARS,
    refresh: bool = False,
    mode: str = "adaptive",
) -> str:
    """Prepend the Gemeo twin context to a system prompt.

    mode: "adaptive" (default) — short brief + tool pointers (~300 tokens)
          "full"               — entire serialized twin (~max_chars tokens)
          "off"                — no injection (returns original)

    Always falls back to the original prompt on any failure.
    """
    if not case_id or mode == "off":
        return system_prompt
    try:
        from . import core as gcore
        twin = gcore.get_gemeo(case_id)
        if twin is None or refresh:
            twin = await gcore.query_gemeo(case_id)
        if twin is None:
            return system_prompt
        if mode == "adaptive":
            block = serialize_twin_brief(twin)
            header = GEMEO_BRIEF_HEADER
            instructions = GEMEO_BRIEF_INSTRUCTIONS
        else:  # full
            block = serialize_twin_for_llm(twin, max_chars=max_chars)
            header = GEMEO_HEADER
            instructions = GEMEO_INSTRUCTIONS
        if not block:
            return system_prompt
        return f"{header}\n{instructions}\n\n{block}\n\n---\n\n{system_prompt}"
    except Exception as e:
        logger.warning(f"inject_context failed for {case_id[:8] if case_id else '?'}: {e}")
        return system_prompt


# ─── Absorb a message back into the twin ──────────────────────────────────

# Lightweight regex extractors. Real impl can use the existing entity
# extractors (bio_tools / phenotype agent). This is the "always-on" pass
# that runs on every message to keep the twin fresh.

_HPO_RE   = re.compile(r"\bHP:(\d{7})\b")
_ORPHA_RE = re.compile(r"\bORPHA:(\d{1,7})\b", re.IGNORECASE)
_GENE_RE  = re.compile(r"\b([A-Z][A-Z0-9]{1,7})\b\s*(?:gene|mutation|variant|c\.|p\.)", re.IGNORECASE)


async def absorb_message(
    case_id: str,
    message_text: str,
    *,
    source: str = "user",
) -> dict:
    """Extract HPO / ORPHA / gene mentions from a free-text message and
    feed them into the twin via `evolve_gemeo`.

    Returns a dict summarising what was absorbed (so the caller can show
    a "X items added to twin" hint in the UI).
    """
    if not case_id or not message_text:
        return {"hpo": [], "orpha": [], "genes": [], "absorbed": False}

    hpo_ids = list({f"HP:{m.group(1)}" for m in _HPO_RE.finditer(message_text)})
    orpha_ids = list({m.group(1) for m in _ORPHA_RE.finditer(message_text)})
    genes_raw = list({m.group(1).upper() for m in _GENE_RE.finditer(message_text)})

    if not (hpo_ids or orpha_ids or genes_raw):
        return {"hpo": [], "orpha": [], "genes": [], "absorbed": False}

    new_phenotypes = [
        {"hpo_id": h, "name": h, "source": source, "status": "extracted"}
        for h in hpo_ids
    ]
    new_genes = [
        {"symbol": g, "source": source, "status": "extracted"}
        for g in genes_raw
    ]

    try:
        from . import core as gcore
        if new_phenotypes or new_genes:
            await gcore.evolve_gemeo(
                case_id,
                new_phenotypes=new_phenotypes,
                new_genes=new_genes,
            )
        return {
            "hpo": hpo_ids,
            "orpha": orpha_ids,
            "genes": genes_raw,
            "absorbed": True,
            "source": source,
        }
    except Exception as e:
        logger.warning(f"absorb_message failed: {e}")
        return {"hpo": hpo_ids, "orpha": orpha_ids, "genes": genes_raw, "absorbed": False, "error": str(e)}