"""Gemeo dataclasses — public types.

JSON-serializable, stable across versions. Internal modules can extend
via `extra: dict` payloads.
"""
from __future__ import annotations
from dataclasses import dataclass, field, asdict
from datetime import datetime, timezone
from typing import Optional, Any
import uuid


def _now() -> str:
    return datetime.now(timezone.utc).isoformat()


def _new_id() -> str:
    return f"gemeo_{uuid.uuid4().hex[:10]}"


# ─── retrieval / cohort ────────────────────────────────────────────────────

@dataclass
class CohortMember:
    space_id: str
    similarity: float
    shared_phenotypes: list = field(default_factory=list)
    shared_diseases: list = field(default_factory=list)
    confirmed_diagnosis: Optional[str] = None
    confirmed_orpha: Optional[str] = None
    sus_region: Optional[str] = None
    source: str = "registry"  # registry | space | literature


@dataclass
class Cohort:
    members: list = field(default_factory=list)
    method: str = "knn_fused"
    radius: float = 0.0
    n_total_population: int = 0
    centroid_disease: Optional[dict] = None


# ─── reasoning / subgraph ──────────────────────────────────────────────────

@dataclass
class SubgraphNode:
    id: str
    label: str
    name: str
    code: Optional[str] = None
    weight: float = 1.0
    extra: dict = field(default_factory=dict)


@dataclass
class SubgraphEdge:
    source: str
    target: str
    rel: str
    weight: float = 1.0
    evidence: list = field(default_factory=list)


@dataclass
class Subgraph:
    nodes: list = field(default_factory=list)
    edges: list = field(default_factory=list)
    paths: list = field(default_factory=list)
    method: str = "cypher_sparsify"
    target_disease: Optional[str] = None


# ─── prediction / trajectory ───────────────────────────────────────────────

@dataclass
class TrajectoryHorizon:
    months: int
    state: str
    risk_score: float = 0.0
    confidence_low: float = 0.0
    confidence_high: float = 0.0
    expected_phenotypes: list = field(default_factory=list)
    expected_complications: list = field(default_factory=list)


@dataclass
class TrajectorySpec:
    horizons: list = field(default_factory=list)
    model: str = "tgnn_bootstrap"
    natural_history_basis: list = field(default_factory=list)


# ─── risk / survival ───────────────────────────────────────────────────────

@dataclass
class RiskSpec:
    overall_severity: float = 0.0
    progression_risk: float = 0.0
    treatment_urgency: float = 0.0
    survival_curve: list = field(default_factory=list)
    top_complications: list = field(default_factory=list)
    model: str = "rule_based"


# ─── drugs / repurposing ───────────────────────────────────────────────────

@dataclass
class DrugSpec:
    candidates: list = field(default_factory=list)
    model: str = "kg_walks"
    n_evaluated: int = 0


# ─── trials ────────────────────────────────────────────────────────────────

@dataclass
class TrialSpec:
    matches: list = field(default_factory=list)
    model: str = "trialgpt_bootstrap"
    n_searched: int = 0


# ─── active learning ───────────────────────────────────────────────────────

@dataclass
class NextQuestion:
    hpo_id: str
    name: str
    rationale: str
    information_gain: float = 0.0
    discriminates_between: list = field(default_factory=list)
    asks_in_pcdt: bool = False


# ─── SUS grounding ─────────────────────────────────────────────────────────

@dataclass
class SusCheck:
    disease_orpha: Optional[str] = None
    has_pcdt: bool = False
    pcdt_url: Optional[str] = None
    therapy_pcdt_recommended: list = field(default_factory=list)
    therapy_dispensed_in_uf: dict = field(default_factory=dict)
    nearest_centro: Optional[dict] = None
    triagem_neonatal_includes: bool = False
    associations: list = field(default_factory=list)


# ─── viz ───────────────────────────────────────────────────────────────────

@dataclass
class VizData:
    nodes: list = field(default_factory=list)
    links: list = field(default_factory=list)
    center_id: Optional[str] = None
    legend: dict = field(default_factory=dict)


# ─── what-if ───────────────────────────────────────────────────────────────

@dataclass
class WhatIfResult:
    intervention: dict = field(default_factory=dict)
    delta_risk: float = 0.0
    delta_trajectory: list = field(default_factory=list)
    new_risk: Optional[RiskSpec] = None
    new_trajectory: Optional[TrajectorySpec] = None
    rationale: str = ""
    confidence: float = 0.5


# ─── DDI ───────────────────────────────────────────────────────────────────

@dataclass
class DdiPair:
    drug_a: str
    drug_b: str
    rxcui_a: Optional[str] = None
    rxcui_b: Optional[str] = None
    severity: str = "unknown"   # contraindicated | major | moderate | minor | unknown
    mechanism: str = ""
    evidence_level: str = ""
    management: str = ""
    references: list = field(default_factory=list)


@dataclass
class DdiSpec:
    pairs: list = field(default_factory=list)
    n_pairs_evaluated: int = 0
    regimen_risk: str = "none"  # none | minor | moderate | major | contraindicated
    model: str = "kg_walks"


# ─── multi-specialist consult ─────────────────────────────────────────────

@dataclass
class SpecialistOpinion:
    specialty: str
    opinion: str
    confidence: float
    key_concerns: list = field(default_factory=list)
    recommended_next_steps: list = field(default_factory=list)
    red_flags: list = field(default_factory=list)


@dataclass
class ConsultSpec:
    opinions: list = field(default_factory=list)
    synthesis: str = ""
    panel: list = field(default_factory=list)


# ─── pharmacogenomics ─────────────────────────────────────────────────────

@dataclass
class PharmacogenAssessment:
    gene: str
    variant: Optional[str]
    drug: str
    rxcui: Optional[str] = None
    expected_phenotype: str = ""
    recommendation: str = ""
    dose_modification: str = ""
    cpic_level: str = ""           # A | B | C | D | ""
    evidence: str = ""
    confidence: float = 0.5
    source: str = "cpic"          # cpic | pathway


@dataclass
class PharmacogenSpec:
    assessments: list = field(default_factory=list)
    n_pairs: int = 0
    n_actionable: int = 0
    model: str = "cpic_kg"


# ─── family / pedigree ─────────────────────────────────────────────────────

@dataclass
class RelativeRisk:
    relation: str   # sibling | parent | offspring | mother | son | daughter
    recurrence_risk: float
    carrier_screening_recommended: bool = False
    rationale: str = ""


@dataclass
class FamilySpec:
    inheritance_mode: str           # AR | AD | XLR | XLD | MITOCHONDRIAL | DE_NOVO | UNKNOWN
    relatives: list = field(default_factory=list)
    notes: str = ""


# ─── reverse phenotyping ──────────────────────────────────────────────────

@dataclass
class ReversePhenoItem:
    hpo_id: str
    name: str
    expected_frequency: float
    definition: str = ""


@dataclass
class ReversePhenoSpec:
    disease_orpha: Optional[str] = None
    items: list = field(default_factory=list)


# ─── protocol compliance ──────────────────────────────────────────────────

@dataclass
class ComplianceGap:
    category: str       # therapy | exam | referral | off_protocol
    expected: str
    got: Optional[str] = None
    priority: str = "medium"   # low | medium | high
    rationale: str = ""


@dataclass
class ProtocolComplianceSpec:
    disease_orpha: Optional[str] = None
    score: float = 0.0
    gaps: list = field(default_factory=list)
    notes: str = ""


# ─── simulation ───────────────────────────────────────────────────────────

@dataclass
class SimulationOutcome:
    metric: str
    horizon_months: int
    n: int
    mean: float
    p05: float
    p50: float
    p95: float


@dataclass
class SimulationSpec:
    n_runs: int = 0
    intervention: Optional[dict] = None
    horizon_outcomes: list = field(default_factory=list)
    survival_summary: list = field(default_factory=list)
    median_severity: float = 0.0


# ─── the central twin ──────────────────────────────────────────────────────

@dataclass
class GemeoTwin:
    id: str = field(default_factory=_new_id)
    case_id: Optional[str] = None
    patient_id: Optional[str] = None
    created_at: str = field(default_factory=_now)
    updated_at: str = field(default_factory=_now)

    embedding: Optional[list] = None
    embedding_dim: int = 0
    diagnoses: list = field(default_factory=list)

    cohort: Optional[Cohort] = None
    subgraph: Optional[Subgraph] = None
    trajectory: Optional[TrajectorySpec] = None
    risk: Optional[RiskSpec] = None
    drugs: Optional[DrugSpec] = None
    trials: Optional[TrialSpec] = None
    next_questions: list = field(default_factory=list)
    sus_check: Optional[SusCheck] = None
    viz_data: Optional[VizData] = None

    # Phase-2 case-driven additions
    ddi: Optional[DdiSpec] = None
    consult: Optional[ConsultSpec] = None
    pharmacogen: Optional[PharmacogenSpec] = None
    family: Optional[FamilySpec] = None
    reverse_pheno: Optional[ReversePhenoSpec] = None
    protocol_compliance: Optional[ProtocolComplianceSpec] = None

    # Snapshot state
    snapshot_versions: list = field(default_factory=list)
    n_phenotypes: int = 0
    n_genes: int = 0
    n_labs: int = 0

    extra: dict = field(default_factory=dict)

    def to_dict(self) -> dict:
        return asdict(self)