Update README.md
Browse files
README.md
CHANGED
|
@@ -7,7 +7,10 @@ library_name: peft
|
|
| 7 |
|
| 8 |
<!-- Provide a quick summary of what the model is/does. -->
|
| 9 |
This model is used to predict mutation fitness score of protein DLG4_RAT (Disks large homolog 4). Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins.
|
| 10 |
-
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels.
|
|
|
|
|
|
|
|
|
|
| 11 |
|
| 12 |
### Task type
|
| 13 |
protein level regression
|
|
|
|
| 7 |
|
| 8 |
<!-- Provide a quick summary of what the model is/does. -->
|
| 9 |
This model is used to predict mutation fitness score of protein DLG4_RAT (Disks large homolog 4). Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins.
|
| 10 |
+
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels.
|
| 11 |
+
Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses
|
| 12 |
+
in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly.
|
| 13 |
+
May regulate the intracellular trafficking of ADR1B.
|
| 14 |
|
| 15 |
### Task type
|
| 16 |
protein level regression
|