{
  "framework": "Explainable-Acute-Leukemia-Mortality-Predictor",
  "model": "Logistic Regression",
  "created_at_utc": "2026-01-28T12:59:21.790386",
  "schema": {
    "features": [
      "Age (years)",
      "Gender",
      "Ethnicity",
      "Type of Leukemia",
      "ECOG",
      "Risk Assesment",
      "WBCs on Admission\n ( x10^9/L)",
      "Hb on Admission  (g/L)",
      "LDH on Admission (IU/L)",
      "MDx Leukemia Screen 1",
      "Pre-Induction bone marrow biopsy blasts %",
      "Date of 1st Bone Marrow biopsy (Date of Diagnosis)",
      "Post-Induction  MRD",
      "Date of 1st CR",
      "First_Induction",
      "death_date",
      "last_followup_date",
      "Thrombocytopenia",
      "Bleeding",
      "B Symptoms",
      "Lymphadenopathy",
      "CNS Involvement",
      "Extramedullary Involvement",
      "fish_inv16/cbfb_myh11",
      "fish_t8;21/runx1_runx1t1",
      "fish_t15;17/PML-RARA",
      "fish_KMT2A-MLL/11q23",
      "fish_BCR-ABL1/t9;22",
      "fish_ETV6-RUNX1/t12;21",
      "fish_TCF3_PBX1/t1;19",
      "fish_IGH/14q32rearr",
      "fish_CRLF2 rearr",
      "fish_NUP214/9q34",
      "fish_Other",
      "fish_del7q/monosomy7",
      "fish_TP53/del17p",
      "fish_del13q",
      "fish_del11q",
      "Number of FISH alteration",
      "ngs_FLT3",
      "ngs_NPM1",
      "ngs_CEBPA",
      "ngs_DNMT3A",
      "ngs_IDH1",
      "ngs_IDH2",
      "ngs_TET2",
      "ngs_TP53",
      "ngs_RUNX1",
      "ngs_Other",
      "ngs_spliceosome",
      "No. of ngs_mutation"
    ],
    "numeric": [
      "Age (years)",
      "WBCs on Admission\n ( x10^9/L)",
      "Hb on Admission  (g/L)",
      "LDH on Admission (IU/L)",
      "Pre-Induction bone marrow biopsy blasts %",
      "Date of 1st Bone Marrow biopsy (Date of Diagnosis)",
      "Date of 1st CR",
      "death_date",
      "last_followup_date",
      "Number of FISH alteration",
      "No. of ngs_mutation"
    ],
    "categorical": [
      "Gender",
      "Ethnicity",
      "Type of Leukemia",
      "ECOG",
      "Risk Assesment",
      "MDx Leukemia Screen 1",
      "Post-Induction  MRD",
      "First_Induction",
      "Thrombocytopenia",
      "Bleeding",
      "B Symptoms",
      "Lymphadenopathy",
      "CNS Involvement",
      "Extramedullary Involvement",
      "fish_inv16/cbfb_myh11",
      "fish_t8;21/runx1_runx1t1",
      "fish_t15;17/PML-RARA",
      "fish_KMT2A-MLL/11q23",
      "fish_BCR-ABL1/t9;22",
      "fish_ETV6-RUNX1/t12;21",
      "fish_TCF3_PBX1/t1;19",
      "fish_IGH/14q32rearr",
      "fish_CRLF2 rearr",
      "fish_NUP214/9q34",
      "fish_Other",
      "fish_del7q/monosomy7",
      "fish_TP53/del17p",
      "fish_del13q",
      "fish_del11q",
      "ngs_FLT3",
      "ngs_NPM1",
      "ngs_CEBPA",
      "ngs_DNMT3A",
      "ngs_IDH1",
      "ngs_IDH2",
      "ngs_TET2",
      "ngs_TP53",
      "ngs_RUNX1",
      "ngs_Other",
      "ngs_spliceosome"
    ],
    "label": "Outcome Event"
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  "feature_reduction": {
    "variance_threshold": 0.0,
    "use_dimred": false,
    "svd_components": null,
    "use_feature_selection": true,
    "l1_C": 1.0,
    "selection_method": "SelectFromModel(L1 saga, threshold=median)",
    "note": "If SVD is enabled, SHAP becomes component-level (less interpretable)."
  },
  "shap_background": {
    "file": "background.csv",
    "max_rows": 200,
    "note": "Raw (pre-transform) background sample for SHAP LinearExplainer."
  },
  "survival": {
    "enabled": true,
    "duration_units": "days",
    "model": "CoxPHFitter (lifelines) with one-hot for categoricals",
    "required_columns_any_of": {
      "start": [
        "Date of 1st Bone Marrow biopsy (Date of Diagnosis)",
        "Diagnosis Date",
        "Dx Date"
      ],
      "event": [
        "Outcome Event",
        "Death",
        "Event"
      ],
      "death": [
        "death_date",
        "Death Date",
        "Date of Death"
      ],
      "censor": [
        "last_followup_date",
        "Last Follow up date",
        "Last Follow-up Date",
        "Last Seen Date"
      ]
    },
    "used_columns": {
      "start": "Date of 1st Bone Marrow biopsy (Date of Diagnosis)",
      "event": "Outcome Event",
      "death": "death_date",
      "censor": "last_followup_date"
    },
    "notes": "Survival model trained successfully."
  },
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}