---
license: apache-2.0
tags:
  - protein-design
  - alphafold
  - pxdesign
  - blackwell
  - pytorch
---

# PXDesign-Blackwell Weights Mirror

This is a HuggingFace-hosted mirror of the ByteDance-origin weights used by
[PXDesign-Blackwell](https://github.com/001TMF/pxdesign-blackwell). It exists
so operators behind Great Firewall / corporate proxies / slow-from-US links
can `hf download` instead of reaching TOS-Beijing directly.

## Contents

| File | Size | Upstream origin |
|------|------|-----------------|
| `checkpoint/pxdesign_v0.1.0.pt` | ~530 MB | `pxdesign.tos-cn-beijing.volces.com/release_model/pxdesign_v0.1.0.pt` |
| `checkpoint/protenix-v2.pt` | ~1.8 GB | [`TMF001/protenix-v2-weights`](https://huggingface.co/TMF001/protenix-v2-weights) |
| `checkpoint/protenix_base_default_v0.5.0.pt` | ~1.4 GB | `pxdesign.tos-cn-beijing.volces.com/release_model/protenix_base_default_v0.5.0.pt` |
| `checkpoint/protenix_mini_default_v0.5.0.pt` | ~513 MB | `pxdesign.tos-cn-beijing.volces.com/release_model/protenix_mini_default_v0.5.0.pt` |
| `checkpoint/protenix_mini_tmpl_v0.5.0.pt` | ~513 MB | `pxdesign.tos-cn-beijing.volces.com/release_model/protenix_mini_tmpl_v0.5.0.pt` |
| `ccd_cache/components.v20240608.cif` | ~408 MB | `pxdesign.tos-cn-beijing.volces.com/release_data/components.v20240608.cif` |
| `ccd_cache/components.v20240608.cif.rdkit_mol.pkl` | ~121 MB | `pxdesign.tos-cn-beijing.volces.com/release_data/components.v20240608.cif.rdkit_mol.pkl` |
| `ccd_cache/clusters-by-entity-40.txt` | ~21 MB | `pxdesign.tos-cn-beijing.volces.com/release_data/clusters-by-entity-40.txt` |
| `weights.sha256` | <1 KB | Committed manifest — verify downloads against it |

AF2 parameters (Google-hosted at `storage.googleapis.com/alphafold/alphafold_params_2022-12-06.tar`)
and ProteinMPNN weights (GitHub-hosted at `github.com/dauparas/ProteinMPNN`) are **not** mirrored
here; the repo's `scripts/fetch_weights.sh` pulls those from their canonical sources.

## Verification

```bash
hf download TMF001/pxdesign-weights --local-dir ./weights
# Then in the pxdesign-blackwell repo:
bash scripts/verify_mirror.sh ./weights
```

## Provenance

These files are byte-identical copies from the upstream sources listed above.
SHA256 checksums are pinned in `weights.sha256` and validated in `scripts/verify_mirror.sh`.

## License

- `checkpoint/*.pt` and `ccd_cache/*` — Apache 2.0 (per upstream ByteDance PXDesign repo).
- `protenix-v2.pt` — Apache 2.0 (per upstream Protenix release).