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README.md ADDED
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+ ---
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+ language:
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+ - dna
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+ library_name: transformers
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+ tags:
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+ - DNA
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+ - BERT
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+ - language-model
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+ - genomics
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+ license: mit
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+ ---
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+
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+ # DNABERT-2
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+
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+ Weights and tokenizer for [DNABERT-2](https://arxiv.org/abs/2306.15006)
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+ (Zhou et al., arXiv 2023), loaded with the shared MosaicBERT implementation
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+ from [Taykhoom/MosaicBERT-updated](https://huggingface.co/Taykhoom/MosaicBERT-updated).
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+
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+ DNABERT-2 is a foundation model trained on large-scale multi-species genome data.
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+ It replaces k-mer tokenization with Byte Pair Encoding (BPE), uses ALiBi positional
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+ biases instead of learned embeddings, and incorporates a GLU-based FFN for improved
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+ efficiency.
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+
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+ **This repo contains only weights and tokenizer files.** The model code is loaded
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+ automatically from `Taykhoom/MosaicBERT-updated` via `trust_remote_code=True`.
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+
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+ ## Architecture
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+
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+ | Parameter | Value |
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+ |---|---|
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+ | Layers | 12 |
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+ | Attention heads | 12 |
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+ | Embedding dimension | 768 |
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+ | Intermediate size | 3072 |
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+ | Vocabulary size | 4096 (BPE) |
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+ | Positional encoding | ALiBi (no hard length limit) |
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+ | Max sequence length | ~10000 nt (practical; ALiBi resizes dynamically) |
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+ | Parameters | ~117M |
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+
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+ ### Tokenization
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+
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+ Uses Byte Pair Encoding (BPE) tokenization via `PreTrainedTokenizerFast`.
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+ No k-mer pre-processing required.
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+
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+ ## Pretraining
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+
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+ - **Objective:** Masked Language Modeling
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+ - **Data:** Large-scale multi-species genome (GRCh38 and others)
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+ - **Source checkpoint:** `pytorch_model.bin` from [zhihan1996/DNABERT-2-117M](https://huggingface.co/zhihan1996/DNABERT-2-117M)
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+
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+ ## Parity Verification
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+
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+ Hidden-state representations verified identical (max abs diff = 0.00) to the original
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+ implementation at all 13 representation levels (embedding + 12 transformer layers).
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+ SDPA verified (max abs diff < 1e-4). Verified on GPU with PyTorch 2.7 / CUDA 12.9.
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+
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+ ## Related Models
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+
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+ See the full [DNABERT collection](https://huggingface.co/collections/Taykhoom/dnabert-6a20958f8ce004ea4e985e7b).
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+
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+ | Model | Architecture | Notes |
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+ |---|---|---|
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+ | [DNABERT-3mer](https://huggingface.co/Taykhoom/DNABERT-3mer) | BERT + k-mer | k=3 |
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+ | [DNABERT-4mer](https://huggingface.co/Taykhoom/DNABERT-4mer) | BERT + k-mer | k=4 |
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+ | [DNABERT-5mer](https://huggingface.co/Taykhoom/DNABERT-5mer) | BERT + k-mer | k=5 |
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+ | [DNABERT-6mer](https://huggingface.co/Taykhoom/DNABERT-6mer) | BERT + k-mer | k=6 |
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+ | **[DNABERT-2](https://huggingface.co/Taykhoom/DNABERT2)** | **MosaicBERT + BPE + ALiBi** | **This model** |
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+ | [DNABERT-S](https://huggingface.co/Taykhoom/DNABERT-S) | MosaicBERT + BPE + ALiBi | Species-aware contrastive fine-tune |
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+
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+ ## Usage
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+
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+ ### Embedding generation
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+
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+ ```python
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+ import torch
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+ from transformers import AutoTokenizer, AutoModel
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+
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+ tokenizer = AutoTokenizer.from_pretrained("Taykhoom/DNABERT2", trust_remote_code=True)
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+ model = AutoModel.from_pretrained("Taykhoom/DNABERT2", trust_remote_code=True)
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+ model.eval()
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+
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+ sequences = ["ACGTAGCATCGGATCTATCTATCGACACTTGG", "ATCGATCGATCGATCG"]
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+ enc = tokenizer(sequences, return_tensors="pt", padding=True)
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+
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+ with torch.no_grad():
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+ out = model(**enc)
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+
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+ cls_emb = out.last_hidden_state[:, 0, :] # (batch, 768)
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+ mean_emb = out.last_hidden_state.mean(dim=1) # (batch, 768) -- mean pooling
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+
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+ # Intermediate layers
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+ out_all = model(**enc, output_hidden_states=True)
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+ layer6_emb = out_all.hidden_states[6]
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+ ```
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+
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+ ### MLM logits
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+
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+ ```python
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+ import torch
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+ from transformers import AutoTokenizer, AutoModelForMaskedLM
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+
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+ tokenizer = AutoTokenizer.from_pretrained("Taykhoom/DNABERT2", trust_remote_code=True)
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+ model = AutoModelForMaskedLM.from_pretrained("Taykhoom/DNABERT2", trust_remote_code=True)
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+ model.eval()
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+
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+ enc = tokenizer(["ACGTAGCAT[MASK]GGATCTATC"], return_tensors="pt")
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+ with torch.no_grad():
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+ logits = model(**enc).logits # (1, seq_len, 4096)
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+ ```
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+
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+ ### Attention implementation
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+
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+ ```python
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+ # SDPA (default on PyTorch >= 2.0)
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+ model = AutoModel.from_pretrained("Taykhoom/DNABERT2", trust_remote_code=True,
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+ attn_implementation="sdpa")
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+
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+ # Flash Attention 2
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+ model = AutoModel.from_pretrained("Taykhoom/DNABERT2", trust_remote_code=True,
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+ attn_implementation="flash_attention_2",
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+ torch_dtype=torch.bfloat16)
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+ ```
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+
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+ ## Implementation Notes
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+
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+ The original DNABERT-2 codebase uses a Triton-based flash attention implementation
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+ (`flash_attn_triton.py`). This HF port uses
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+ [Taykhoom/MosaicBERT-updated](https://huggingface.co/Taykhoom/MosaicBERT-updated)
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+ which replaces it with the standard `flash-attn` package, and also adds
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+ `attn_implementation="sdpa"` support. These were not part of the original codebase.
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+
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+ ## Citation
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+
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+ ```bibtex
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+ @misc{zhou2023_dnabert2,
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+ title = {{DNABERT}-2: Efficient Foundation Model and Benchmark For Multi-Species Genome},
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+ author = {Zhou, Zhihan and Ji, Yanrong and Li, Weijian and Dutta, Pratik and
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+ Davuluri, Ramana and Liu, Han},
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+ year = {2023},
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+ eprint = {2306.15006},
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+ archivePrefix = {arXiv},
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+ primaryClass = {q-bio.GN}
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+ }
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+ ```
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+
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+ ## Credits
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+
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+ Original DNABERT-2 model and code by Zhou et al.
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+ Source: [GitHub](https://github.com/MAGICS-LAB/DNABERT_2).
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+ The HF conversion code was authored primarily by [Claude Code](https://claude.ai/code)
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+ and reviewed manually by Taykhoom Dalal.
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+
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+ ## License
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+
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+ MIT, following the original repository.
config.json ADDED
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+ {
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+ "alibi_starting_size": 512,
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+ "architectures": [
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+ "BertForMaskedLM"
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+ ],
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+ "auto_map": {
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+ "AutoConfig": "Taykhoom/MosaicBERT-updated--configuration_bert.BertConfig",
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+ "AutoModelForSequenceClassification": "Taykhoom/MosaicBERT-updated--bert_layers.BertForSequenceClassification"
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+ },
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+ "classifier_dropout": null,
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+ "hidden_act": "gelu",
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+ "model_type": "bert",
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+ "num_attention_heads": 12,
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+ "num_hidden_layers": 12,
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+ "position_embedding_type": "absolute",
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+ "transformers_version": "4.57.6",
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+ "type_vocab_size": 2,
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+ "use_cache": true,
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+ "vocab_size": 4096
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+ }
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special_tokens_map.json ADDED
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+ {
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+ "pad_token": "[PAD]",
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+ "sep_token": "[SEP]",
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+ "unk_token": "[UNK]"
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+ }
tokenizer.json ADDED
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tokenizer_config.json ADDED
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+ {
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