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ProtNHF is a generative model for protein sequences that enables continuous, controllable design without retraining. It leverages neural Hamiltonian flows with a Transformer-based energy function to map a latent Gaussian to protein embeddings. Sampling-time bias functions allow steering properties like amino acid composition or net charge smoothly and predictably. Generated sequences achieve high quality as measured by ESM-2 pseudo-perplexity and AlphaFold2 pLDDT scores. ProtNHF provides a flexible, physically interpretable framework for programmable protein sequence generation.
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## Model Details
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This current upload corresponds to model/architecture version 1.
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warmup_epochs: 5
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ProtNHF is a generative model for protein sequences that enables continuous, controllable design without retraining. It leverages neural Hamiltonian flows with a Transformer-based energy function to map a latent Gaussian to protein embeddings. Sampling-time bias functions allow steering properties like amino acid composition or net charge smoothly and predictably. Generated sequences achieve high quality as measured by ESM-2 pseudo-perplexity and AlphaFold2 pLDDT scores. ProtNHF provides a flexible, physically interpretable framework for programmable protein sequence generation.
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The source code is available here: https://github.com/bharath-raghavan/ProtNHF.git
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## Model Details
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This current upload corresponds to model/architecture version 1.
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warmup_epochs: 5
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```
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## Citation
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If you use ProtNHF in your research, please cite:
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B. Raghavan, and D. M. Rogers
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**ProtNHF: Neural Hamiltonian Flows for Controllable Protein Sequence Generation**
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arXiv:xxxx.xxxxx (2026)
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```bibtex
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@article{raghavan2026protnhf,
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title = {ProtNHF: Neural Hamiltonian Flows for Controllable Protein Sequence Generation},
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author = {Raghavan, Bharath and Rogers, David M.},
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journal = {arXiv preprint arXiv:xxxx.xxxxx},
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year = {2026}
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}
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