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141bacd | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 | # Pan-Pancreas PANDA
Multi-dataset corpus for pancreas cell identity + zero-shot transfer + mechanistic discovery.
## Corpus datasets
| Accession | Study | Cells | Species | Modality | Role |
|---|---|---:|---|---|---|
| GSE132188 | Bastidas-Ponce 2019 | 33,896 | mouse | 10x v2 | Anchor E15.5 endocrine progenitor time course (local) |
| GSE84133 | Baron 2016 | ~10,000 | mouse+human | inDrops | Adult islet reference |
| GSE85241 | Muraro 2016 | ~2,126 | human | CEL-Seq2 | Deep-coverage adult islet |
| E-MTAB-5061 | Segerstolpe 2016 | ~3,514 | human | Smart-seq2 | Deep + T2D covariate |
| GSE81076 | Grun 2016 | ~1,595 | human | CEL-Seq | Modality diversity |
| GSE101099 | Byrnes 2018 | ~12,000 | mouse | inDrops | Independent-lab time course |
## Held-out labeled validation
**Baron 2016 mouse subset** — has full canonical islet labels (alpha/beta/delta/gamma/epsilon/
ductal/acinar/endothelial/immune) but is a completely independent scRNA-seq study from a
different lab. Zero-shot transfer of PANDA-pancreas predictions to Baron gives an
apples-to-apples accuracy measurement across labs.
## Held-out unlabeled discovery target
**Veres 2019 hPSC-directed differentiation (GSE114412)** — human pluripotent stem cell
differentiation to SC-beta cells with an off-target enterochromaffin population. Weakly
labeled by day-of-differentiation only; PANDA's cell-type predictions become hypothesis-
generating annotations.
## Ontology (11 classes)
- alpha
- beta
- delta
- gamma (PP)
- epsilon
- endocrine-progenitor
- ductal
- acinar
- endothelial
- immune
- other/mesenchymal
|