upload discovery

discovery/62_clonal_purity.csv

@@ -0,0 +1,36 @@
+library,n,dominant_class,purity
+LSK_d2_1,7617,MPP,0.9581199947485887
+LSK_d2_2,7549,MPP,0.9613193800503378
+LSK_d4_2_2,5567,MPP,0.7474402730375427
+LSK_d4_1_3,5551,MPP,0.7290578274184831
+LSK_d2_3,5290,MPP,0.952930056710775
+LSK_d4_2_3,5206,MPP,0.7568190549366116
+LK_d6_2_1,4964,myeloid,0.5167203867848509
+LK_d6_2_2,4958,myeloid,0.5389269866881807
+LSK_d6_2_2,4836,MPP,0.45533498759305213
+LK_d6_1_1,4732,myeloid,0.5439560439560439
+LSK_d4_1_2,4619,MPP,0.7389045247889153
+LSK_d4_2_1,4353,MPP,0.7362738341373766
+LK_d6_1_2,4337,myeloid,0.5893474752132811
+LSK_d4_1_1,4154,MPP,0.7327876745305729
+LSK_d6_2_3,4141,MPP,0.45568703211784595
+LSK_d6_1_2,4040,MPP,0.5007425742574257
+LSK_d6_2_1,3777,MPP,0.4516812284882182
+LK_d4_2,3550,myeloid,0.5416901408450704
+d4_2_1,3297,myeloid,0.5001516530178951
+d4_2_2,3133,myeloid,0.4921800191509735
+LSK_d6_1_3,3125,MPP,0.47936
+LSK_d6_1_1,3120,MPP,0.4855769230769231
+LK_d4_1,3005,myeloid,0.5271214642262895
+d6_1_1,2931,myeloid,0.6281132719208461
+d6_2_2,2631,myeloid,0.5526415811478526
+d2_3,2587,MPP,0.664089679165056
+d2_2,2497,MPP,0.6611934321185422
+d6_1_2,2226,myeloid,0.6181491464510332
+d6_2_3,2160,myeloid,0.5504629629629629
+d6_2_1,2157,myeloid,0.5099675475197033
+d4_1_2,2102,myeloid,0.5176022835394862
+d4_2_4,2092,myeloid,0.5444550669216062
+d4_1_1,1868,myeloid,0.5187366167023555
+d2_1,1861,MPP,0.6630843632455669
+LK_d2,848,MPP,0.7818396226415094

discovery/62_lineage_markers.csv

@@ -0,0 +1,91 @@
+class,gene,logfc
+MPP,H2afy,3.945
+MPP,Igfbp4,3.695
+MPP,Gas5,2.974
+MPP,Ifitm1,1.928
+MPP,Ttf1,2.582
+MPP,Plac8,2.703
+MPP,Srgn,2.221
+MPP,Cd34,5.126
+MPP,Ccdc62,2.725
+MPP,Tmem176b,4.479
+MPP,H2-Q7,3.324
+MPP,Muc13,3.795
+MPP,Myc,3.105
+MPP,Ptprcap,2.958
+MPP,Unc13d,2.327
+basophil-mast,Cpa3,9.424
+basophil-mast,Csf2rb2,6.533
+basophil-mast,Gata2,6.89
+basophil-mast,Hdc,6.892
+basophil-mast,Csf2rb,4.308
+basophil-mast,Cyp11a1,5.566
+basophil-mast,Furin,5.065
+basophil-mast,F2r,5.892
+basophil-mast,Mcpt8,7.15
+basophil-mast,Ccl6,5.846
+basophil-mast,Rnf128,6.24
+basophil-mast,Prss34,8.493
+basophil-mast,Il1rl1,6.214
+basophil-mast,Slc7a8,5.473
+basophil-mast,Ctla2a,4.516
+erythroid,Hbb-bt,9.753
+erythroid,Car2,8.112
+erythroid,Hbb-bs,10.198
+erythroid,Gmpr,5.413
+erythroid,Podxl,5.956
+erythroid,Alox5,4.135
+erythroid,Scin,4.696
+erythroid,Tph1,6.471
+erythroid,Bex4,6.825
+erythroid,Mt1,3.472
+erythroid,Gata2,3.842
+erythroid,Bcl11a,4.128
+erythroid,Car1,9.179
+erythroid,Klf1,7.508
+erythroid,F2r,3.549
+lymphoid,Ighm,7.338
+lymphoid,Ly6a,4.255
+lymphoid,H2-Aa,5.683
+lymphoid,H2-Eb1,5.619
+lymphoid,Ptprcap,3.296
+lymphoid,Ccr9,7.933
+lymphoid,Cd74,4.191
+lymphoid,Ly6d,7.933
+lymphoid,Gsn,2.038
+lymphoid,Tsc22d1,3.545
+lymphoid,Satb1,4.193
+lymphoid,Gas5,1.858
+lymphoid,Nrgn,4.455
+lymphoid,Lztfl1,3.655
+lymphoid,Lmo4,2.361
+megakaryocyte,Pf4,10.017
+megakaryocyte,Tmsb4x,2.541
+megakaryocyte,Itga2b,6.65
+megakaryocyte,Itgb3,6.5
+megakaryocyte,F2r,6.036
+megakaryocyte,Cd9,4.461
+megakaryocyte,Mrvi1,7.367
+megakaryocyte,Plek,4.28
+megakaryocyte,Ppbp,8.415
+megakaryocyte,Ctla2a,4.748
+megakaryocyte,Nrgn,6.226
+megakaryocyte,Slc14a1,6.758
+megakaryocyte,Pbx1,5.085
+megakaryocyte,Rab27b,5.759
+megakaryocyte,Slc6a4,7.105
+myeloid,Lyz2,6.602
+myeloid,Wfdc21,5.316
+myeloid,Itgb2,4.034
+myeloid,Cybb,4.721
+myeloid,Itgam,4.276
+myeloid,S100a8,5.886
+myeloid,S100a9,6.04
+myeloid,Lcn2,4.274
+myeloid,Lgals3,3.608
+myeloid,Gda,3.385
+myeloid,Cd52,3.502
+myeloid,Msrb1,3.013
+myeloid,Tyrobp,2.998
+myeloid,Anxa1,2.98
+myeloid,Mpp1,2.827

discovery/62_time_course_class_fractions.csv

@@ -0,0 +1,7 @@
+row_0,2,4,6
+MPP,0.8801019505115225,0.5590036497102914,0.2868569317447123
+basophil-mast,0.010301249601755814,0.08373713837969358,0.16966842153874573
+erythroid,0.005876314205812595,0.005917891828360517,0.012062436501339244
+lymphoid,0.013664200502672662,0.01791863414231808,0.0036205781841692065
+megakaryocyte,0.007610888881022337,0.017939253974472647,0.02972199131800129
+myeloid,0.08244539629721406,0.3154834319648638,0.4980696407130322

discovery/62_time_course_enrichment.csv

@@ -0,0 +1,7 @@
+class,n_d16,n_d2,log2_fold_d16_vs_d2,fisher_p
+erythroid,0,166,6.402,1.0
+megakaryocyte,0,215,6.031,1.0
+basophil-mast,0,291,5.596,1.0
+lymphoid,0,386,5.19,1.0
+myeloid,0,2329,2.6,1.0
+MPP,0,24862,-0.816,1.0

discovery/63_nestorowa_novel_markers.csv

@@ -0,0 +1,41 @@
+cluster,gene,logfc
+0,Ctla2a,inf
+0,Mpl,inf
+0,Ca2,inf
+0,Myct1,247.036
+0,Angpt1,inf
+0,Adgrg1,inf
+0,Meis1,807.145
+0,Rab37,544.157
+1,Irf8,inf
+1,Tyrobp,inf
+1,Mpo,
+1,Ctsg,inf
+1,Ms4a6c,inf
+1,Prtn3,inf
+1,Emb,inf
+1,Ccr2,637.555
+2,Myo1d,5.76
+2,Ces2g,275.724
+2,Gm36997,2.817
+2,Ca1,inf
+2,Slc25a21,18.719
+2,Klf1,139.961
+2,Abcg4,1.321
+2,Plekhg1,1.597
+3,Dntt,inf
+3,Satb1,inf
+3,Ighm,inf
+3,Flt3,inf
+3,Tbxa2r,418.672
+3,Gpr171,inf
+3,Wfdc17,672.987
+3,Il12a,inf
+4,S100a8,627.069
+4,Gm11505,14.338
+4,Cebpe,302.751
+4,Dio2,116.587
+4,Chd7,319.981
+4,Elane,
+4,Ncam1,245.325
+4,Alas1,inf

discovery/66_dahlin_class_per_genotype.csv

@@ -0,0 +1,7 @@
+pred_label,Kit_W41,WT
+MPP,0.5356047700170358,0.8352315542446229
+basophil-mast,0.00020442930153321976,0.0003014188214524081
+erythroid,0.42589437819420783,0.1333778284926906
+lymphoid,0.004224872231686542,0.008676556074665748
+megakaryocyte,0.017512776831345826,0.018451137856050983
+myeloid,0.0165587734241908,0.003961504510517364

discovery/66_dahlin_enrichment.csv

@@ -0,0 +1,7 @@
+class,n_Kit_W41,n_WT,pct_Kit,pct_WT,log2_fold_Kit_vs_WT,fisher_p
+lymphoid,62,403,0.422,0.868,-1.019,1.1545391885743078e-08
+MPP,7860,38794,53.56,83.523,-0.641,0.0
+basophil-mast,3,14,0.02,0.03,-0.245,0.7771359232821795
+megakaryocyte,257,857,1.751,1.845,-0.072,0.47903014259009224
+erythroid,6250,6195,42.589,13.338,1.675,0.0
+myeloid,243,184,1.656,0.396,2.061,3.8891606152344816e-48

discovery/67_dahlin_module_scores.csv

@@ -0,0 +1,36 @@
+class,module,delta_Kit_minus_WT,MannU_p
+MPP,MYC_targets,-0.0064,0.00010398596455421202
+MPP,Integrated_stress,0.0459,0.0
+MPP,Apoptosis_pro,0.0172,4.080645248367736e-30
+MPP,Apoptosis_anti,-0.0323,4.3365016482978846e-23
+MPP,Erythroid_dev,0.0531,8.474326908489118e-166
+MPP,Cell_cycle,-0.0239,3.497293083053643e-05
+MPP,Kit_signaling,-0.1233,0.0
+erythroid,MYC_targets,0.0318,4.819670934912549e-15
+erythroid,Integrated_stress,0.0755,0.0
+erythroid,Apoptosis_pro,-0.0426,6.610600325020102e-123
+erythroid,Apoptosis_anti,-0.0069,2.0861544130647765e-05
+erythroid,Erythroid_dev,-0.0741,3.2837324384882784e-62
+erythroid,Cell_cycle,-0.0363,6.380670327767912e-51
+erythroid,Kit_signaling,-0.1265,0.0
+megakaryocyte,MYC_targets,-0.0444,0.004131534534152324
+megakaryocyte,Integrated_stress,0.0633,2.5808429648738003e-18
+megakaryocyte,Apoptosis_pro,0.006,0.4649007815493228
+megakaryocyte,Apoptosis_anti,-0.0734,3.7165070897877136e-06
+megakaryocyte,Erythroid_dev,-0.0314,0.038478731810907996
+megakaryocyte,Cell_cycle,-0.1056,1.3807888180856783e-08
+megakaryocyte,Kit_signaling,-0.0871,7.141719000616502e-15
+lymphoid,MYC_targets,-0.0011,0.8339504656447909
+lymphoid,Integrated_stress,0.0603,6.4827018160004595e-06
+lymphoid,Apoptosis_pro,0.0229,0.19466177850957944
+lymphoid,Apoptosis_anti,-0.0056,0.5070554102157346
+lymphoid,Erythroid_dev,0.0271,0.09010058250986579
+lymphoid,Cell_cycle,-0.0069,0.9817764026068148
+lymphoid,Kit_signaling,-0.1453,9.155436412387304e-07
+myeloid,MYC_targets,0.0403,0.13479543913748937
+myeloid,Integrated_stress,0.0457,5.536746427342943e-09
+myeloid,Apoptosis_pro,0.0032,0.24681615379662236
+myeloid,Apoptosis_anti,0.0103,0.0015312855491831031
+myeloid,Erythroid_dev,0.0336,5.842982689295575e-07
+myeloid,Cell_cycle,-0.1167,4.042515911212186e-09
+myeloid,Kit_signaling,-0.0509,7.305623929461819e-05

discovery/67_dahlin_within_class_de.csv

@@ -0,0 +1,151 @@
+class,up_in,gene,logfc,padj
+MPP,Kit_W41,Rps12,1.568,0.0
+MPP,Kit_W41,Rpl23,1.087,0.0
+MPP,Kit_W41,Rps20,1.2,0.0
+MPP,Kit_W41,Rplp1,1.171,0.0
+MPP,Kit_W41,Rpl30,1.431,0.0
+MPP,Kit_W41,Tpt1,1.343,0.0
+MPP,Kit_W41,Rpl12,1.32,0.0
+MPP,Kit_W41,Rpl28,1.119,0.0
+MPP,Kit_W41,Rplp2,0.943,0.0
+MPP,Kit_W41,Rps15a,0.885,0.0
+MPP,Kit_W41,Rpl7,0.987,0.0
+MPP,Kit_W41,Rps10,1.081,0.0
+MPP,Kit_W41,Rps17,0.959,0.0
+MPP,Kit_W41,Eef1a1,0.889,0.0
+MPP,Kit_W41,Rps27a,0.759,0.0
+MPP,WT,Pabpc1,1.142,0.0
+MPP,WT,Rps28,0.585,0.0
+MPP,WT,Ddx5,1.153,0.0
+MPP,WT,Rps27rt,2.152,0.0
+MPP,WT,Zfp36l2,2.044,0.0
+MPP,WT,Rsrp1,1.573,0.0
+MPP,WT,Malat1,1.298,0.0
+MPP,WT,Morf4l1,1.065,0.0
+MPP,WT,Rps27,0.503,0.0
+MPP,WT,Mbnl1,1.706,0.0
+MPP,WT,Serinc3,1.626,0.0
+MPP,WT,Hnrnpk,0.842,0.0
+MPP,WT,mt-Co1,0.582,0.0
+MPP,WT,mt-Atp6,0.405,0.0
+MPP,WT,Eif4g2,1.211,0.0
+erythroid,Kit_W41,Rps12,1.376,0.0
+erythroid,Kit_W41,Rplp1,1.215,0.0
+erythroid,Kit_W41,Rpl30,1.262,0.0
+erythroid,Kit_W41,Rpl23,0.891,0.0
+erythroid,Kit_W41,Rps20,1.034,0.0
+erythroid,Kit_W41,Rpl12,1.106,0.0
+erythroid,Kit_W41,Rplp2,0.763,0.0
+erythroid,Kit_W41,Rps10,0.842,0.0
+erythroid,Kit_W41,Rpl28,0.868,0.0
+erythroid,Kit_W41,Rps13,0.833,0.0
+erythroid,Kit_W41,Rpl27a,0.722,0.0
+erythroid,Kit_W41,Rack1,0.875,0.0
+erythroid,Kit_W41,Rps17,0.757,0.0
+erythroid,Kit_W41,Rpl7,0.717,0.0
+erythroid,Kit_W41,Tpt1,0.993,0.0
+erythroid,WT,Pabpc1,1.214,0.0
+erythroid,WT,Rsrp1,1.847,0.0
+erythroid,WT,Ddx5,0.955,0.0
+erythroid,WT,Rpl3,0.448,0.0
+erythroid,WT,Gm8730,1.109,0.0
+erythroid,WT,Hnrnpf,0.772,0.0
+erythroid,WT,Hnrnpk,0.765,0.0
+erythroid,WT,Morf4l1,0.944,0.0
+erythroid,WT,Eef2,0.617,0.0
+erythroid,WT,Serinc3,1.424,0.0
+erythroid,WT,Rps27rt,1.69,0.0
+erythroid,WT,Hnrnpa2b1,0.69,0.0
+erythroid,WT,Rps28,0.464,0.0
+erythroid,WT,Thrap3,1.133,0.0
+erythroid,WT,Top2b,1.593,0.0
+megakaryocyte,Kit_W41,Rpl23,1.076,2.477643845344121e-125
+megakaryocyte,Kit_W41,Rplp1,1.124,1.5349768909390112e-124
+megakaryocyte,Kit_W41,Rpl28,1.056,5.238047426982703e-124
+megakaryocyte,Kit_W41,Rps12,1.506,5.238047426982703e-124
+megakaryocyte,Kit_W41,Rps20,1.158,2.0017157083815246e-123
+megakaryocyte,Kit_W41,Tpt1,1.225,4.13342595841548e-122
+megakaryocyte,Kit_W41,Rpl12,1.244,1.9260365788176396e-121
+megakaryocyte,Kit_W41,Rpl30,1.381,2.031687382914219e-121
+megakaryocyte,Kit_W41,Rplp2,0.888,1.3147523970954425e-119
+megakaryocyte,Kit_W41,Rps17,0.888,4.128059492923606e-118
+megakaryocyte,Kit_W41,Rps15,0.798,2.501606652495474e-116
+megakaryocyte,Kit_W41,Rps15a,0.851,2.731895229589466e-115
+megakaryocyte,Kit_W41,Rpl7,0.902,2.312863610506342e-114
+megakaryocyte,Kit_W41,Rps10,0.972,3.0236699018135662e-114
+megakaryocyte,Kit_W41,Rps27a,0.717,2.0270424258604796e-113
+megakaryocyte,WT,Pabpc1,1.189,9.057867980729365e-87
+megakaryocyte,WT,Malat1,1.059,4.1424320387679114e-67
+megakaryocyte,WT,Morf4l1,1.025,1.521264695028277e-60
+megakaryocyte,WT,Ddx5,1.001,7.747567997112924e-58
+megakaryocyte,WT,Rps27rt,2.156,2.842204181571947e-57
+megakaryocyte,WT,Rps28,0.535,7.4917467871262905e-56
+megakaryocyte,WT,Hnrnpf,0.821,4.2325279595420595e-54
+megakaryocyte,WT,Rsrp1,1.541,2.1710193791420565e-53
+megakaryocyte,WT,Hnrnpk,0.872,5.240134536413951e-52
+megakaryocyte,WT,Rps27,0.446,5.4097109080565346e-49
+megakaryocyte,WT,Serinc3,1.639,7.047922653350595e-49
+megakaryocyte,WT,Pdcd4,1.197,5.172101321933511e-47
+megakaryocyte,WT,Pbx1,1.007,1.9280031178359777e-45
+megakaryocyte,WT,Mbnl1,1.545,5.293928326372336e-45
+megakaryocyte,WT,mt-Co1,0.545,1.7986352360343962e-44
+lymphoid,Kit_W41,Tpt1,1.5,2.2124231538295334e-30
+lymphoid,Kit_W41,Rplp1,1.308,4.929805547130703e-30
+lymphoid,Kit_W41,Rpl23,1.264,4.929805547130703e-30
+lymphoid,Kit_W41,Rps12,1.608,1.732664809971845e-29
+lymphoid,Kit_W41,Rps20,1.22,5.870666387886333e-29
+lymphoid,Kit_W41,Rpl30,1.573,1.0769087381224238e-28
+lymphoid,Kit_W41,Rps10,1.14,5.883111493600475e-28
+lymphoid,Kit_W41,Rps21,1.416,1.4329290752422256e-27
+lymphoid,Kit_W41,Rps24,0.926,8.424897882171758e-26
+lymphoid,Kit_W41,Rpl28,1.128,1.0102989755835374e-25
+lymphoid,Kit_W41,Rplp2,0.991,2.5095236225790882e-25
+lymphoid,Kit_W41,Rps25,1.104,4.3431651599914065e-25
+lymphoid,Kit_W41,Rpl12,1.34,1.2939799104041183e-24
+lymphoid,Kit_W41,Rpl7,1.037,1.8592416854451373e-24
+lymphoid,Kit_W41,Rps17,1.051,2.2059875828040522e-24
+lymphoid,WT,Rsrp1,1.619,1.9202847529292828e-15
+lymphoid,WT,Rps27rt,2.654,2.006828984079777e-15
+lymphoid,WT,Mbnl1,1.849,5.260833681916221e-15
+lymphoid,WT,Pabpc1,1.2,7.435535471012115e-15
+lymphoid,WT,Rps28,0.647,5.585540823868464e-14
+lymphoid,WT,Morf4l1,1.22,7.258522818709768e-12
+lymphoid,WT,Luc7l2,1.746,2.4470213170953e-11
+lymphoid,WT,Ddx5,1.042,5.4930068613140067e-11
+lymphoid,WT,Zfp36l2,2.109,1.0170605478844157e-10
+lymphoid,WT,Hnrnpk,0.914,1.523089411925536e-09
+lymphoid,WT,Rps27,0.478,4.191794548456065e-09
+lymphoid,WT,Malat1,1.025,8.729047781167121e-09
+lymphoid,WT,Hmgb1,0.953,1.5593788532943488e-08
+lymphoid,WT,Hnrnpf,0.923,1.0323118820168785e-07
+lymphoid,WT,Top2b,1.985,1.3561566893027846e-06
+myeloid,Kit_W41,Rps12,1.573,1.267849180385614e-59
+myeloid,Kit_W41,Eef1a1,1.415,1.267849180385614e-59
+myeloid,Kit_W41,Rpl23,1.093,5.195532429804291e-59
+myeloid,Kit_W41,Tpt1,1.357,9.862070786293558e-58
+myeloid,Kit_W41,Rack1,1.338,9.862070786293558e-58
+myeloid,Kit_W41,Rpl28,1.054,9.862070786293558e-58
+myeloid,Kit_W41,Rplp1,1.287,5.391153626466462e-57
+myeloid,Kit_W41,Rpl30,1.24,8.99282223217876e-57
+myeloid,Kit_W41,Rps20,1.2,1.1809782046288963e-56
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discovery/70_prototype_cross_system_pairs.csv

@@ -0,0 +1,756 @@
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discovery/70_prototype_effective_dim.json

@@ -0,0 +1,26 @@
+{
+  "pan_skin": {
+    "K": 13,
+    "effective_dim": 11.075447082519531,
+    "cos_offdiag_mean": -0.020954914391040802,
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+  },
+  "hematopoiesis": {
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+    "effective_dim": 11.32563304901123,
+    "cos_offdiag_mean": 0.002725333906710148,
+    "cos_offdiag_std": 0.15220414102077484,
+    "cos_offdiag_max": 0.6192497611045837,
+    "cos_offdiag_min": -0.44832512736320496
+  },
+  "pancreas": {
+    "K": 20,
+    "effective_dim": 10.8522367477417,
+    "cos_offdiag_mean": 0.03679059073328972,
+    "cos_offdiag_std": 0.20739242434501648,
+    "cos_offdiag_max": 0.4839359223842621,
+    "cos_offdiag_min": -0.5196306109428406
+  }
+}

discovery/70_prototype_full_29x29.csv

@@ -0,0 +1,49 @@
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discovery/70_prototype_intra_cosine_hematopoiesis.csv

@@ -0,0 +1,16 @@
+,LT-HSC,MPP,T-cell,basophil-mast,endothelial,erythroid,fibroblast,lymphoid,macrophage,megakaryocyte,monocyte,myeloid,naive-B,pro-B,stromal
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discovery/70_prototype_intra_cosine_pan_skin.csv

@@ -0,0 +1,14 @@
+,HF-ORS,HF-placode,basal-IFE,endothelial,fibroblast-papillary,fibroblast-reticular,granular,immune,melanoblast,melanocyte,melanocyte-precursor,sebaceous,spinous
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+endothelial,-0.02863442,-0.06857434,-0.25555235,0.99999976,0.025393732,0.08308215,-0.12716791,0.017155405,0.06545475,-0.0937086,-0.028540445,0.061858293,-0.100668475
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+melanocyte-precursor,0.118165225,0.12581547,0.08282731,-0.028540445,-0.05037053,0.025964621,-0.0056521557,-0.014504435,0.2912298,0.0038670718,0.9999997,-0.040381953,-0.12874357
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discovery/70_prototype_intra_cosine_pancreas.csv

@@ -0,0 +1,21 @@
+,Fev-EP,acinar,adult-alpha,adult-beta,alpha,alpha_progenitor,beta,beta_progenitor,delta,ductal,endocrine-progenitor,endocrine-progenitor-primed,endothelial,epsilon,exocrine,gamma,immune,mesenchyme,pancreatic-progenitor,proliferating
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+beta_progenitor,0.07795627,-0.087148614,-0.09351562,-0.1876467,-0.16581954,0.18445596,-0.21547423,0.9999997,0.046392247,0.25146917,-0.106564775,0.008019621,-0.12227952,0.17290267,0.21726987,-0.050449986,-0.09826723,-0.040401407,-0.06150832,0.028453877
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+proliferating,-0.22572824,-0.21916053,0.12551276,-0.13928321,0.03863075,-0.003476688,0.007470061,0.028453877,-0.3441932,-0.23717201,-0.048067953,0.04145366,-0.12672587,-0.19883019,0.17856142,-0.14495926,-0.19280554,-0.022634665,0.2388331,0.99999994

discovery/70_prototype_summary.json

@@ -0,0 +1,182 @@
+{
+  "systems": [
+    "pan_skin",
+    "hematopoiesis",
+    "pancreas"
+  ],
+  "eff_dims": {
+    "pan_skin": {
+      "K": 13,
+      "effective_dim": 11.075447082519531,
+      "cos_offdiag_mean": -0.020954914391040802,
+      "cos_offdiag_std": 0.11849680542945862,
+      "cos_offdiag_max": 0.29122981429100037,
+      "cos_offdiag_min": -0.34952273964881897
+    },
+    "hematopoiesis": {
+      "K": 15,
+      "effective_dim": 11.32563304901123,
+      "cos_offdiag_mean": 0.002725333906710148,
+      "cos_offdiag_std": 0.15220414102077484,
+      "cos_offdiag_max": 0.6192497611045837,
+      "cos_offdiag_min": -0.44832512736320496
+    },
+    "pancreas": {
+      "K": 20,
+      "effective_dim": 10.8522367477417,
+      "cos_offdiag_mean": 0.03679059073328972,
+      "cos_offdiag_std": 0.20739242434501648,
+      "cos_offdiag_max": 0.4839359223842621,
+      "cos_offdiag_min": -0.5196306109428406
+    }
+  },
+  "null_cross_cos_mean": 0.00515016021229889,
+  "null_cross_cos_std": 0.08944799549034006,
+  "obs_cross_cos_mean": -0.004553857784824668,
+  "obs_cross_cos_std": 0.09070717160395421,
+  "obs_cross_cos_max": 0.26673153042793274,
+  "top10_pos_pairs": [
+    {
+      "sys_a": "pan_skin",
+      "class_a": "granular",
+      "sys_b": "pancreas",
+      "class_b": "endothelial",
+      "cos": 0.26673153042793274
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "T-cell",
+      "sys_b": "pancreas",
+      "class_b": "beta",
+      "cos": 0.23246313631534576
+    },
+    {
+      "sys_a": "pan_skin",
+      "class_a": "sebaceous",
+      "sys_b": "pancreas",
+      "class_b": "mesenchyme",
+      "cos": 0.22086213529109955
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "basophil-mast",
+      "sys_b": "pancreas",
+      "class_b": "exocrine",
+      "cos": 0.21516495943069458
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "MPP",
+      "sys_b": "pancreas",
+      "class_b": "adult-beta",
+      "cos": 0.21175406873226166
+    },
+    {
+      "sys_a": "pan_skin",
+      "class_a": "HF-placode",
+      "sys_b": "hematopoiesis",
+      "class_b": "endothelial",
+      "cos": 0.20595994591712952
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "T-cell",
+      "sys_b": "pancreas",
+      "class_b": "endothelial",
+      "cos": 0.20566368103027344
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "macrophage",
+      "sys_b": "pancreas",
+      "class_b": "ductal",
+      "cos": 0.20559315383434296
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "megakaryocyte",
+      "sys_b": "pancreas",
+      "class_b": "mesenchyme",
+      "cos": 0.20387932658195496
+    },
+    {
+      "sys_a": "pan_skin",
+      "class_a": "fibroblast-papillary",
+      "sys_b": "pancreas",
+      "class_b": "endocrine-progenitor",
+      "cos": 0.19662468135356903
+    }
+  ],
+  "top10_neg_pairs": [
+    {
+      "sys_a": "pan_skin",
+      "class_a": "HF-placode",
+      "sys_b": "hematopoiesis",
+      "class_b": "T-cell",
+      "cos": -0.21106307208538055
+    },
+    {
+      "sys_a": "pan_skin",
+      "class_a": "melanoblast",
+      "sys_b": "hematopoiesis",
+      "class_b": "basophil-mast",
+      "cos": -0.21275341510772705
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "basophil-mast",
+      "sys_b": "pancreas",
+      "class_b": "immune",
+      "cos": -0.22489789128303528
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "LT-HSC",
+      "sys_b": "pancreas",
+      "class_b": "endocrine-progenitor",
+      "cos": -0.22823907434940338
+    },
+    {
+      "sys_a": "pan_skin",
+      "class_a": "basal-IFE",
+      "sys_b": "pancreas",
+      "class_b": "alpha_progenitor",
+      "cos": -0.2297169268131256
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "pro-B",
+      "sys_b": "pancreas",
+      "class_b": "gamma",
+      "cos": -0.2377726435661316
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "basophil-mast",
+      "sys_b": "pancreas",
+      "class_b": "beta",
+      "cos": -0.2504867613315582
+    },
+    {
+      "sys_a": "hematopoiesis",
+      "class_a": "basophil-mast",
+      "sys_b": "pancreas",
+      "class_b": "acinar",
+      "cos": -0.25345271825790405
+    },
+    {
+      "sys_a": "pan_skin",
+      "class_a": "basal-IFE",
+      "sys_b": "pancreas",
+      "class_b": "delta",
+      "cos": -0.2774435877799988
+    },
+    {
+      "sys_a": "pan_skin",
+      "class_a": "immune",
+      "sys_b": "pancreas",
+      "class_b": "beta",
+      "cos": -0.2867254912853241
+    }
+  ]
+}

discovery/80_hematopoiesis_gene_attribution.csv

@@ -0,0 +1,9 @@
+class,src_corpus_class,top_pos_genes,top_pos_attribution,top_neg_genes,top_neg_attribution
+MPP,MPP,"Klf1,Car1,Pf4,Il7r,Mmp8,Hba-a1,Cpa3,2017_9_CD45minus_GGGCATCGTCATTAGC,2017_9_CD45minus_TTTGGTTAGCTACCTA,2017_9_CD45minus_GCGCGATGTGCGCTTG,2017_9_CD45minus_TACTTACAGTATTGGA,2017_9_CD45minus_TGGCGCAGTGATGCCC,2017_9_CD45minus_TCGTACCGTGTTCTTT,2017_9_CD45minus_GCGGGTTTCTGAGGGA,2017_9_CD45minus_TATCTCAGTCTCCCTA,2017_9_CD45minus_GTGGGTCCATCGGTTA,2017_9_CD45minus_GCGCGATAGATGCCTT,2017_9_CD45minus_GGAATAAAGTTTGCGT,2017_9_CD45minus_GTGTTAGTCCATGCTC,2017_9_CD45minus_TTCTTAGTCCTGCCAT","+0.159,+0.146,+0.117,+0.098,+0.069,+0.050,+0.001,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000","Slamf1,Cd48,Meis1,Flt3,Csf1r,Mllt3,Hlf,Mpo,Itga2b,Ctss,Elane,Procr,Gata1,Sell,Dntt","-0.349,-0.230,-0.191,-0.147,-0.141,-0.136,-0.135,-0.120,-0.099,-0.096,-0.096,-0.071,-0.058,-0.055,-0.051"
+UNK,UNK,"Sell,Elane,Mpo,Hlf,Procr,Il7r,Car2,Mecom,Fgd5,Mllt3,Vpreb3,2017_9_CD45minus_GTACTCCAGAGCAATT,2017_9_CD45minus_GGACATTTCCAATGGT,2017_9_CD45minus_TCGAGGCCAAGGCTCC,2017_9_totalBM_ACTGAGTTCAGGCAAG,2017_9_totalBM_ACTATCTAGACTAGGC,2017_9_CD45minus_GTGCGGTTCTTCATGT,2017_9_totalBM_ACGAGCCCATTCTCAT,2017_9_CD45minus_TTTGCGCGTCCGAAGA,2017_9_totalBM_AAATGCCTCAATCTCT","+2.498,+0.371,+0.343,+0.301,+0.117,+0.059,+0.054,+0.008,+0.007,+0.006,+0.001,-0.000,-0.000,-0.000,-0.000,-0.000,-0.000,-0.000,-0.000,-0.000","Csf1r,Wfdc17,Itga2b,Gata1,Mmp8,Gp1bb,Pf4,Cpa3,Car1,Meis1,Klf1,Ms4a2,Flt3,Cd48,Slamf1","-1.370,-0.906,-0.833,-0.535,-0.483,-0.433,-0.423,-0.322,-0.322,-0.285,-0.202,-0.141,-0.103,-0.085,-0.025"
+basophil-mast,basophil-mast,"Cpa3,Flt3,Dntt,Ms4a2,Itga2b,Hlf,Meis1,Mllt3,Slamf1,Mecom,Gata1,Fgd5,Gp1bb,2017_9_CD45minus_GGGCATCGTCATTAGC,2017_9_CD45minus_GCGCGATGTGCGCTTG,2017_9_CD45minus_TTTGGTTAGCTACCTA,2017_9_totalBM_ACATACGGTAAGGGAA,2017_9_CD45minus_TATCTCAGTCTCCCTA,2017_9_CD45minus_TGGCGCAGTGATGCCC,2017_9_CD45minus_GGAATAAAGTTTGCGT","+0.859,+0.830,+0.616,+0.527,+0.516,+0.391,+0.326,+0.260,+0.117,+0.087,+0.084,+0.019,+0.017,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000","Wfdc17,Mmp8,Csf1r,Ctss,Sell,Klf1,Car1,Il7r,Elane,Mpo,Procr,Hba-a1,Car2,Cd48,Pf4","-1.384,-1.384,-1.298,-1.258,-0.818,-0.727,-0.639,-0.480,-0.418,-0.304,-0.225,-0.178,-0.172,-0.134,-0.130"
+erythroid,erythroid,"Car2,Klf1,Car1,Mllt3,Meis1,Hba-a1,Flt3,Slamf1,Hlf,Gata1,Cd48,Mpo,Dntt,Elane,Procr,Mecom,Fgd5,Vpreb3,2017_9_CD45minus_GTACTCCAGAGCAATT,2017_9_CD45minus_GGACATTTCCAATGGT","+0.319,+0.306,+0.290,+0.249,+0.245,+0.201,+0.169,+0.167,+0.160,+0.119,+0.116,+0.081,+0.071,+0.067,+0.066,+0.051,+0.011,+0.000,+0.000,+0.000","Mmp8,Cpa3,Wfdc17,Ctss,Pf4,Gp1bb,Csf1r,Il7r,Itga2b,Ms4a2,Sell,2017_9_CD45minus_GGGCATCGTCATTAGC,2017_9_CD45minus_TTTGGTTAGCTACCTA,2017_9_CD45minus_GCGCGATGTGCGCTTG,2017_9_CD45minus_TGGCGCAGTGATGCCC","-0.152,-0.146,-0.145,-0.121,-0.113,-0.105,-0.091,-0.070,-0.062,-0.060,-0.028,-0.000,-0.000,-0.000,-0.000"
+lymphoid,lymphoid,"Cpa3,Klf1,Dntt,Flt3,Ms4a2,Ctss,Fgd5,Mecom,Hba-a1,2017_9_CD45minus_GTACTCCAGAGCAATT,2017_9_CD45minus_GGACATTTCCAATGGT,2017_9_CD45minus_TCGAGGCCAAGGCTCC,2017_9_CD45minus_TTTGCGCGTCCGAAGA,2017_9_CD45minus_GTGCGGTTCTTCATGT,2017_9_CD45minus_TCACGAATCGGCTACG,2017_9_CD45minus_GTAGGCCCATGTCTCC,2017_9_totalBM_ACTATCTAGACTAGGC,2017_9_totalBM_ACTGAGTTCAGGCAAG,2017_9_CD45minus_GTATCTTCAGCTTCGG,2017_9_totalBM_ACGATACCAATCGAAA","+0.098,+0.086,+0.048,+0.036,+0.024,+0.013,+0.004,+0.003,+0.002,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000","Slamf1,Gp1bb,Mllt3,Meis1,Elane,Mpo,Csf1r,Mmp8,Itga2b,Hlf,Sell,Pf4,Car2,Wfdc17,Cd48","-0.234,-0.179,-0.125,-0.117,-0.108,-0.101,-0.088,-0.080,-0.068,-0.067,-0.064,-0.057,-0.056,-0.054,-0.048"
+megakaryocyte,megakaryocyte,"Pf4,Gp1bb,Itga2b,Gata1,Mpo,Elane,Slamf1,Cpa3,Meis1,Ms4a2,Hlf,Car2,Vpreb3,Fgd5,2017_9_CD45minus_GTACTCCAGAGCAATT,2017_9_CD45minus_GGACATTTCCAATGGT,2017_9_CD45minus_GTGCGGTTCTTCATGT,2017_9_CD45minus_TCGAGGCCAAGGCTCC,2017_9_CD45minus_TTTGCGCGTCCGAAGA,2017_9_CD45minus_TCACGAATCGGCTACG","+1.171,+1.075,+0.810,+0.547,+0.485,+0.423,+0.373,+0.356,+0.273,+0.270,+0.204,+0.005,+0.001,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000","Wfdc17,Ctss,Mmp8,Csf1r,Il7r,Klf1,Car1,Flt3,Dntt,Cd48,Sell,Procr,Hba-a1,Mecom,Mllt3","-0.744,-0.729,-0.689,-0.531,-0.382,-0.347,-0.312,-0.263,-0.163,-0.119,-0.096,-0.069,-0.063,-0.022,-0.017"
+myeloid,myeloid,"Elane,Mpo,Car1,Klf1,Sell,Mmp8,Car2,Wfdc17,Hba-a1,Procr,Ctss,Csf1r,Fgd5,Vpreb3,2017_9_CD45minus_GGGCATCGTCATTAGC,2017_9_CD45minus_TTTGGTTAGCTACCTA,2017_9_CD45minus_TACTTACAGTATTGGA,2017_9_CD45minus_GCGGGTTTCTGAGGGA,2017_9_CD45minus_TGGCGCAGTGATGCCC,2017_9_CD45minus_TCGTACCGTGTTCTTT","+0.314,+0.276,+0.254,+0.222,+0.160,+0.100,+0.087,+0.066,+0.044,+0.030,+0.016,+0.010,+0.007,+0.002,+0.000,+0.000,+0.000,+0.000,+0.000,+0.000","Cpa3,Ms4a2,Itga2b,Mllt3,Gata1,Meis1,Hlf,Flt3,Dntt,Slamf1,Il7r,Gp1bb,Pf4,Cd48,Mecom","-0.398,-0.368,-0.311,-0.286,-0.264,-0.198,-0.152,-0.152,-0.131,-0.087,-0.073,-0.056,-0.045,-0.033,-0.004"
+unassigned,unassigned,"Slamf1,2017_9_CD45minus_GGGCATCGTCATTAGC,2017_9_CD45minus_TTTGGTTAGCTACCTA,Flt3,2017_9_CD45minus_GCGCGATGTGCGCTTG,2017_9_CD45minus_TGGCGCAGTGATGCCC,2017_9_CD45minus_TACTTACAGTATTGGA,2017_9_CD45minus_TCGTACCGTGTTCTTT,2017_9_CD45minus_GCGGGTTTCTGAGGGA,2017_9_CD45minus_TATCTCAGTCTCCCTA,2017_9_CD45minus_GTGGGTCCATCGGTTA,Hlf,2017_9_CD45minus_GCGCGATAGATGCCTT,Dntt,2017_9_CD45minus_GGAATAAAGTTTGCGT,2017_9_CD45minus_GTGTTAGTCCATGCTC,2017_9_CD45minus_TTCTTAGTCCTGCCAT,2017_9_CD45minus_TCGTAGAGTGCAACGA,2017_9_CD45minus_GGCAATTCACGGCTAC,2017_9_CD45minus_TAGTTGGAGATCCTGT","+0.143,+0.136,+0.134,+0.128,+0.123,+0.122,+0.122,+0.122,+0.121,+0.121,+0.119,+0.119,+0.119,+0.115,+0.114,+0.114,+0.110,+0.109,+0.108,+0.107","Car1,Klf1,Pf4,Elane,Mpo,Car2,2017_9_CD45minus_GTACTCCAGAGCAATT,2017_9_CD45minus_GGACATTTCCAATGGT,Gp1bb,2017_9_CD45minus_TCGAGGCCAAGGCTCC,2017_9_CD45minus_TTTGCGCGTCCGAAGA,2017_9_CD45minus_GTGCGGTTCTTCATGT,Hba-a1,2017_9_CD45minus_TCACGAATCGGCTACG,Sell","-0.174,-0.147,-0.128,-0.096,-0.063,-0.059,-0.050,-0.042,-0.042,-0.040,-0.040,-0.039,-0.035,-0.034,-0.033"

discovery/80_hematopoiesis_pc_attribution.csv

@@ -0,0 +1,9 @@
+,PC1,PC2,PC3,PC4,PC5,PC6,PC7,PC8,PC9,PC10,PC11,PC12,PC13,PC14,PC15,PC16,PC17,PC18,PC19,PC20,PC21,PC22,PC23,PC24,PC25,PC26,PC27,PC28,PC29,PC30,PC31,PC32,PC33,PC34,PC35,PC36,PC37,PC38,PC39,PC40,PC41,PC42,PC43,PC44,PC45,PC46,PC47,PC48,PC49,PC50
+MPP,0.04980705,-0.10740079,0.072189145,-0.054058675,-0.04243585,-0.58577216,0.033653747,0.15302984,0.05315302,0.04863079,-0.021326354,0.0004594272,-0.0159757,-0.023396015,-0.040363465,0.00043708528,-0.0025060158,0.008922154,-0.056935888,0.11804138,-0.002964029,-0.003825871,0.0049866345,-0.00971301,-0.08499552,-0.027771544,-0.0034459282,-0.020401742,-0.0005830198,3.8692313e-05,-1.7953107e-09,-4.663365e-10,2.7100342e-09,1.6012054e-09,3.8462145e-09,2.9803466e-09,3.1878414e-10,-5.429189e-09,-7.7179524e-10,-1.9111226e-09,-5.9833067e-09,-2.257217e-09,7.960787e-10,3.747491e-10,1.4958949e-09,-2.210043e-09,1.5304916e-09,1.3519496e-09,-5.477196e-09,-2.081285e-09
+UNK,-0.775871,1.6903358,0.028674008,-0.14310636,-0.18729933,-0.014959992,0.029357405,0.031902544,0.034150966,-0.10886351,-0.08341643,-0.011325395,0.019783596,-0.023363352,0.057279542,-0.062607236,0.21127756,0.1538277,-0.13495374,2.4820526,-0.015006432,-0.15905981,0.0036392459,0.0034520195,1.1970716,-0.053095706,-0.006544028,-0.00327235,-5.1491184e-05,-0.00020036462,-1.4740635e-08,3.1724776e-09,6.2867855e-10,-2.1240922e-08,1.9756811e-08,-9.618852e-09,1.1924215e-08,-1.3506792e-09,-3.0570737e-09,4.348659e-09,2.5002185e-08,2.8151588e-09,-1.3371824e-08,-2.772771e-09,3.4692258e-09,6.0126113e-09,-1.749867e-08,-1.3261801e-08,6.524911e-08,-5.351639e-09
+basophil-mast,2.0961597,1.549504,1.6429592,-0.019049741,1.4990411,0.5196987,0.1422073,0.006061381,-0.001314802,0.007970012,0.029698769,0.050545104,-0.0032221067,-0.00012395131,0.029196111,0.031577054,0.0509154,-0.024070648,0.05036619,0.049084984,0.0047623375,-0.029929796,0.004944873,0.08646169,5.7640635e-05,-0.008026041,0.00087043847,0.0047402447,0.00018327574,8.598313e-06,-1.0302621e-09,-8.605635e-10,6.815828e-10,1.3318896e-09,3.738039e-09,-1.257183e-09,-5.980042e-09,4.9562993e-11,-9.388748e-10,3.0116574e-09,1.765018e-09,6.7456325e-09,2.5947391e-10,1.1954229e-09,1.4384614e-09,3.3093267e-10,-2.0480155e-09,3.103689e-09,1.149947e-10,2.3849744e-09
+erythroid,0.31415358,0.27831203,-0.5358224,-0.41887656,0.060513962,0.1818044,0.014396487,0.002762562,0.03846318,0.011028863,0.025720054,0.00508611,0.04074366,0.023509612,-0.00029983584,-0.010405093,0.0012067141,-0.06137639,0.00018081545,0.006677168,0.014229863,0.003342022,0.12714066,0.001484379,-0.00029718544,-0.0005971787,0.0017773317,0.009773168,1.845807e-05,-1.1616364e-06,-2.1996371e-10,1.8019834e-10,-5.7391103e-10,-2.1391222e-10,3.2898972e-10,-6.5423017e-10,-2.6420562e-11,7.0925796e-12,6.622146e-10,1.3917709e-11,-2.2041138e-09,6.9315165e-11,-2.6035764e-11,3.7058594e-09,-5.004139e-10,-5.379022e-10,-1.0205433e-11,-4.934285e-10,8.9459196e-10,3.0387867e-10
+lymphoid,0.032277167,-0.0032224646,0.23574159,-0.20326996,0.048385937,-0.2629469,0.033688456,0.040986322,-0.0020824657,-0.0020478708,-0.12470991,0.038275693,0.03422504,-0.022645706,0.0033310447,0.065300085,0.009476239,0.00036721062,-0.0041999617,0.0026233774,0.00844833,-0.008754206,-0.0013099252,0.031098641,0.072890446,0.005928822,0.0073023583,-0.004915264,-4.0593313e-05,-7.451946e-05,-6.8472845e-11,2.9070444e-09,-2.0874989e-10,-5.020858e-09,8.780308e-09,1.609131e-09,2.669915e-10,4.2229797e-09,3.2541692e-10,2.8408698e-09,6.1682974e-09,-2.3045382e-10,-3.2203302e-09,-7.148969e-10,-2.29036e-09,-2.2670776e-09,1.8962627e-10,7.9367896e-10,2.8398557e-09,1.1698516e-10
+megakaryocyte,1.6136287,0.8147278,0.03683707,1.7978702,-0.10717728,0.34336305,-0.0056371577,-0.0025553545,0.15927695,-0.015446286,0.0055436203,0.11577203,-0.005388428,-0.0066556553,-0.050690196,0.026579823,-0.0071551586,0.00042551785,-0.10435798,0.0042895935,-0.013703311,-0.0048662755,0.0013974677,-0.00024338068,0.00053299597,0.00876406,-0.001545598,0.0072717667,0.00025853427,2.0264466e-07,-1.1654353e-09,2.5912228e-10,4.2972464e-10,2.7574554e-09,-2.4765393e-11,-5.456712e-10,-9.774969e-10,-7.3076885e-11,1.4690984e-09,-1.9455101e-10,2.5830749e-09,3.4290268e-10,1.2877139e-09,5.41542e-12,-4.0378992e-10,1.0192014e-09,5.2336296e-10,-1.4378166e-09,-3.2330408e-10,1.8343808e-09
+myeloid,-0.5384198,0.32597223,-0.48960188,-0.015758965,-0.24420768,-0.48452663,-0.022455676,0.0077027953,-0.15485705,0.10620809,-0.10027199,-0.053354293,0.004197788,-0.008560456,-0.12475578,0.06125294,-0.010800326,0.020077307,0.0012708217,0.020798087,-0.0042372053,-0.061768185,-0.00096516404,-0.0015773658,-0.026946666,0.00012275443,0.008566813,-0.002314653,0.0009888137,1.7170874e-05,1.3442226e-09,-4.2176593e-10,-3.2185439e-09,-2.5056892e-09,1.2495117e-09,2.9153002e-09,2.16531e-09,-5.1228555e-10,4.1754324e-09,5.6788235e-10,-2.3566296e-10,-4.9309734e-09,8.912948e-09,1.8270764e-09,-2.0083164e-09,-3.855436e-10,4.381736e-09,4.1724404e-10,-1.5087458e-10,-5.2298876e-09
+unassigned,0.0011793713,-0.03209238,0.20733355,-0.07653554,0.15058567,0.33487692,0.01906758,-0.0026113437,-0.013014082,0.012573379,0.032832384,0.018424824,0.0014550652,0.020018823,0.06819252,-0.015065781,0.025796035,0.017137166,0.0051406203,-0.013247231,-0.0017955211,0.02487459,0.0011865251,-0.0072358623,0.005359258,0.01563389,-0.0002648115,-0.007157655,-0.00014334226,0.9175328,-0.00081979256,3.460118e-05,0.0015228016,0.0026483848,-0.00056580495,-0.00063956913,-0.000120624485,0.0017401273,0.0012175143,0.0046095448,0.004225852,-0.0014405142,-0.00039708504,0.00064053957,-0.00024021443,0.0009936879,0.00045450896,0.00019001518,-0.0032860555,0.0007540451

discovery/80_hematopoiesis_tf_enrichment.csv

@@ -0,0 +1,81 @@
+class,program,n_genes_in_hvg,sum_attribution,hit_frac_top100_pos
+MPP,erythroid,2,0.20894908905029297,1.0
+MPP,MEP,2,0.10065039247274399,0.5
+MPP,lymphoid,1,0.09765975177288055,1.0
+MPP,megakaryocyte,2,0.017655417323112488,0.5
+MPP,basophil-mast,1,0.000991370528936386,1.0
+MPP,CMP,2,-0.19958645105361938,0.0
+MPP,GMP,2,-0.21658405661582947,0.0
+MPP,myeloid,2,-0.21658405661582947,0.0
+MPP,LT-HSC,7,-0.9145269393920898,0.0
+MPP,MPP,4,-0.9176021218299866,0.0
+UNK,GMP,2,0.7135511636734009,1.0
+UNK,myeloid,2,0.7135511636734009,1.0
+UNK,LT-HSC,7,0.130166694521904,0.7142857142857143
+UNK,lymphoid,1,0.05890309810638428,1.0
+UNK,erythroid,2,-0.20848935842514038,0.0
+UNK,basophil-mast,1,-0.32218265533447266,0.0
+UNK,MPP,4,-0.49715352058410645,0.0
+UNK,MEP,2,-0.7370322346687317,0.0
+UNK,megakaryocyte,2,-1.2559927701950073,0.0
+UNK,CMP,2,-1.9049204587936401,0.0
+basophil-mast,MPP,4,1.1389974355697632,0.75
+basophil-mast,LT-HSC,7,0.9756295680999756,0.8571428571428571
+basophil-mast,basophil-mast,1,0.8592707514762878,1.0
+basophil-mast,megakaryocyte,2,0.38644465804100037,0.5
+basophil-mast,lymphoid,1,-0.48001593351364136,0.0
+basophil-mast,MEP,2,-0.6428260207176208,0.5
+basophil-mast,GMP,2,-0.7214386463165283,0.0
+basophil-mast,myeloid,2,-0.7214386463165283,0.0
+basophil-mast,erythroid,2,-0.9048051834106445,0.0
+basophil-mast,CMP,2,-1.2147239446640015,0.5
+erythroid,LT-HSC,7,0.9483869075775146,1.0
+erythroid,MPP,4,0.6968858242034912,1.0
+erythroid,erythroid,2,0.5074396133422852,1.0
+erythroid,MEP,2,0.42515870928764343,1.0
+erythroid,GMP,2,0.1477297693490982,1.0
+erythroid,myeloid,2,0.1477297693490982,1.0
+erythroid,CMP,2,0.02789357304573059,0.5
+erythroid,lymphoid,1,-0.07044580578804016,0.0
+erythroid,basophil-mast,1,-0.14602431654930115,0.0
+erythroid,megakaryocyte,2,-0.17496448755264282,0.0
+lymphoid,basophil-mast,1,0.09760438650846481,1.0
+lymphoid,erythroid,2,0.08749529719352722,1.0
+lymphoid,MEP,2,0.060996703803539276,0.5
+lymphoid,lymphoid,1,-0.022924788296222687,0.0
+lymphoid,CMP,2,-0.11339698731899261,0.0
+lymphoid,megakaryocyte,2,-0.12472942471504211,0.0
+lymphoid,GMP,2,-0.20885759592056274,0.0
+lymphoid,myeloid,2,-0.20885759592056274,0.0
+lymphoid,MPP,4,-0.3625006675720215,0.25
+lymphoid,LT-HSC,7,-0.5798250436782837,0.2857142857142857
+megakaryocyte,megakaryocyte,2,1.9809125661849976,1.0
+megakaryocyte,GMP,2,0.9075922966003418,1.0
+megakaryocyte,myeloid,2,0.9075922966003418,1.0
+megakaryocyte,LT-HSC,7,0.7423897981643677,0.5714285714285714
+megakaryocyte,basophil-mast,1,0.35562050342559814,1.0
+megakaryocyte,MPP,4,0.2636922001838684,0.5
+megakaryocyte,MEP,2,0.20004802942276,0.5
+megakaryocyte,CMP,2,0.016661524772644043,0.5
+megakaryocyte,lymphoid,1,-0.38151222467422485,0.0
+megakaryocyte,erythroid,2,-0.4104388952255249,0.0
+myeloid,GMP,2,0.5900958776473999,1.0
+myeloid,myeloid,2,0.5900958776473999,1.0
+myeloid,erythroid,2,0.26573097705841064,1.0
+myeloid,MEP,2,-0.042067751288414,0.5
+myeloid,lymphoid,1,-0.0728289932012558,0.0
+myeloid,CMP,2,-0.2534671723842621,0.5
+myeloid,megakaryocyte,2,-0.356108158826828,0.0
+myeloid,basophil-mast,1,-0.398151159286499,0.0
+myeloid,MPP,4,-0.47107750177383423,0.0
+myeloid,LT-HSC,7,-0.6905194520950317,0.2857142857142857
+unassigned,LT-HSC,7,0.45425382256507874,0.2857142857142857
+unassigned,MPP,4,0.4021775424480438,0.5
+unassigned,basophil-mast,1,0.08953403681516647,0.0
+unassigned,lymphoid,1,0.05237260460853577,0.0
+unassigned,CMP,2,0.0459686741232872,0.0
+unassigned,megakaryocyte,2,-0.09065903723239899,0.0
+unassigned,MEP,2,-0.13171806931495667,0.0
+unassigned,GMP,2,-0.1587042510509491,0.0
+unassigned,myeloid,2,-0.1587042510509491,0.0
+unassigned,erythroid,2,-0.1820620745420456,0.0

discovery/80_hematopoiesis_top_tf_per_class.csv

@@ -0,0 +1,25 @@
+class,program,n_genes_in_hvg,sum_attribution,hit_frac_top100_pos
+MPP,erythroid,2,0.20894908905029297,1.0
+MPP,MEP,2,0.10065039247274399,0.5
+MPP,lymphoid,1,0.09765975177288055,1.0
+UNK,GMP,2,0.7135511636734009,1.0
+UNK,myeloid,2,0.7135511636734009,1.0
+UNK,LT-HSC,7,0.130166694521904,0.7142857142857143
+basophil-mast,MPP,4,1.1389974355697632,0.75
+basophil-mast,LT-HSC,7,0.9756295680999756,0.8571428571428571
+basophil-mast,basophil-mast,1,0.8592707514762878,1.0
+erythroid,LT-HSC,7,0.9483869075775146,1.0
+erythroid,MPP,4,0.6968858242034912,1.0
+erythroid,erythroid,2,0.5074396133422852,1.0
+lymphoid,basophil-mast,1,0.09760438650846481,1.0
+lymphoid,erythroid,2,0.08749529719352722,1.0
+lymphoid,MEP,2,0.060996703803539276,0.5
+megakaryocyte,megakaryocyte,2,1.9809125661849976,1.0
+megakaryocyte,myeloid,2,0.9075922966003418,1.0
+megakaryocyte,GMP,2,0.9075922966003418,1.0
+myeloid,GMP,2,0.5900958776473999,1.0
+myeloid,myeloid,2,0.5900958776473999,1.0
+myeloid,erythroid,2,0.26573097705841064,1.0
+unassigned,LT-HSC,7,0.45425382256507874,0.2857142857142857
+unassigned,MPP,4,0.4021775424480438,0.5
+unassigned,basophil-mast,1,0.08953403681516647,0.0

discovery/80_pan_skin_gene_attribution.csv

@@ -0,0 +1,25 @@
+class,src_corpus_class,top_pos_genes,top_pos_attribution,top_neg_genes,top_neg_attribution
+HF-DP,HF-DP,"Itih5,Vstm4,P4ha2,Sfrp5,Egfl6,Gfra2,Grem2,Penk,Lmcd1,Wif1,C1qtnf6,Agtr1a,Pcsk6,Defb6,Alox12e,Stxbp6,Plod1,Gm1673,Mmp23,C1qtnf2","+0.474,+0.355,+0.349,+0.343,+0.326,+0.314,+0.305,+0.303,+0.292,+0.291,+0.284,+0.278,+0.274,+0.271,+0.261,+0.253,+0.252,+0.252,+0.251,+0.247","Bmp4,Dkk2,Ltbp1,Atp1a2,Actc1,Cdh15,Cyp2f2,Edn3,Fam180a,Cilp,Il1r2,Serpina3c,Myod1,6330403K07Rik,Notum","-0.396,-0.360,-0.339,-0.335,-0.331,-0.331,-0.328,-0.322,-0.310,-0.309,-0.309,-0.304,-0.303,-0.303,-0.294"
+HF-ORS,HF-ORS,"Cd68,Spi1,Lilrb4a,Fcer1g,Tyrobp,Alox5ap,Ly6g6e,Ctss,Plek,AI607873,H2-Aa,Csf2rb,H2-Eb1,Cd86,Csf1r,Cfp,H2-Ab1,Ms4a6c,Lilr4b,Ccl9","+0.266,+0.265,+0.259,+0.258,+0.253,+0.247,+0.246,+0.244,+0.244,+0.243,+0.239,+0.237,+0.236,+0.234,+0.234,+0.231,+0.228,+0.227,+0.225,+0.225","Cidea,Cox8b,Lockd,Tnfrsf18,Fcgbp,Cdc20,Ccna2,Cdca3,Ccnb2,Mxd3,Ccnb1,Cdca8,Bcam,Racgap1,Fam64a","-0.186,-0.174,-0.173,-0.170,-0.169,-0.167,-0.160,-0.158,-0.157,-0.156,-0.156,-0.153,-0.153,-0.151,-0.150"
+HF-placode,HF-placode,"Cox8b,Cdo1,Gpx3,Car3,Meg3,Mest,Dlk1,Actc1,Hba-a1,Lpl,Nrp1,Tubb2b,Cdkn1c,Ndn,Agtr2,Hba-a2,Nnat,Igf2,Cidea,Fstl1","+0.288,+0.272,+0.247,+0.244,+0.242,+0.233,+0.226,+0.226,+0.225,+0.224,+0.218,+0.218,+0.218,+0.218,+0.216,+0.216,+0.214,+0.211,+0.211,+0.207","Lmo1,Lhx2,Bcam,Trp63,Atp6v1b1,Fermt1,Pdgfa,Lamc2,Igsf9,Wnt10a,Lgr6,Urah,Golga7b,Sostdc1,Ajuba","-0.522,-0.509,-0.457,-0.426,-0.401,-0.378,-0.375,-0.358,-0.355,-0.347,-0.346,-0.344,-0.344,-0.341,-0.341"
+UNK,UNK,"Hmha1,Rac2,Laptm5,Coro1a,Cd52,Cd53,Ptpn18,AI662270,Hcls1,Ptprcap,Fcer1g,Nkg7,Ctsw,Selplg,Fxyd5,Cd3g,Il2rg,Lcp1,Bin2,Gmfg","+0.866,+0.843,+0.821,+0.786,+0.772,+0.755,+0.744,+0.719,+0.718,+0.698,+0.691,+0.691,+0.689,+0.686,+0.684,+0.684,+0.662,+0.656,+0.648,+0.636","Dpep1,Cox8b,Car3,Fxyd1,Osr2,Cyp2f2,Cyp26b1,Gstm1,Cpz,Htra3,Serpina3n,Penk,Rarres2,Dpt,Cidea","-0.563,-0.532,-0.528,-0.519,-0.498,-0.496,-0.483,-0.482,-0.480,-0.478,-0.473,-0.463,-0.457,-0.445,-0.431"
+basal-IFE,basal-IFE,"Cox8b,Car3,Nnat,Actc1,Hba-a1,Tubb2b,Hba-a2,Mest,Myl1,Hbb-bs,Acta1,Cdo1,Fitm1,Igf2,Sox11,Myog,Agtr2,Ntm,Lix1,Tnni2","+0.691,+0.623,+0.605,+0.580,+0.574,+0.550,+0.549,+0.542,+0.482,+0.481,+0.480,+0.478,+0.472,+0.470,+0.468,+0.449,+0.445,+0.438,+0.436,+0.434","Serpina3n,Htra1,Lmo1,Gas6,Mt2,Ly6a,Clec3b,Ly6c1,Pcolce2,Bcam,Ccl11,Rnase4,Trp63,Rarres2,Scara5","-0.724,-0.712,-0.708,-0.700,-0.699,-0.684,-0.673,-0.670,-0.668,-0.652,-0.641,-0.640,-0.621,-0.611,-0.597"
+basal-multipotent,basal-multipotent,"Gpx3,Pf4,C1qa,Cma1,C1qc,Hbb-bs,C1qb,Cpa3,Lpl,Tpsb2,Ms4a7,Meg3,Emp3,Hba-a1,Cidea,Trem2,Hba-a2,Cidec,Adipoq,Fstl1","+0.060,+0.058,+0.052,+0.051,+0.049,+0.049,+0.049,+0.048,+0.047,+0.046,+0.045,+0.042,+0.041,+0.041,+0.041,+0.041,+0.039,+0.038,+0.038,+0.037","Anxa8,Fam25c,Urah,Ckmt1,Capns2,Trp63,Dsg1a,Calm5,Clca3a2,Alox12e,Calm4,Gata3,Defb6,Pkib,Oas1f","-0.088,-0.078,-0.070,-0.070,-0.070,-0.067,-0.065,-0.065,-0.063,-0.061,-0.060,-0.060,-0.059,-0.058,-0.058"
+dermal-condensate,dermal-condensate,"Car3,Cox8b,Adipoq,Cidec,Cidea,Pnpla2,Chchd10,Lpl,Adig,Gpd1,Ppp1r1a,Agt,Retn,Cma1,Tpsb2,8430408G22Rik,Acta1,Mrap,Myl1,Gpx3","+0.216,+0.213,+0.207,+0.199,+0.168,+0.154,+0.141,+0.134,+0.133,+0.125,+0.123,+0.123,+0.121,+0.116,+0.110,+0.108,+0.107,+0.105,+0.097,+0.091","mt-Atp6,Ctsh,Il11ra1,Gas6,AI607873,Tgfbi,Ifi205,Ifi204,2700094K13Rik,Lhx2,Gcat,Sepp1,Lmnb1,Nfib,Reep4","-0.109,-0.107,-0.102,-0.101,-0.098,-0.095,-0.093,-0.092,-0.092,-0.091,-0.089,-0.088,-0.088,-0.087,-0.086"
+eccrine-duct,eccrine-duct,"Cldn6,Ppp2r2b,Upk1b,Gm266,Smtnl2,Crabp1,Reep6,Upk1a,Cldn8,Cldn23,Wnt5a,Dkk2,Tmem132c,Nrp1,Cldn3,Cox4i2,Slc2a3,Limch1,Snx31,Tspan15","+0.259,+0.256,+0.237,+0.229,+0.224,+0.195,+0.188,+0.175,+0.161,+0.158,+0.155,+0.153,+0.153,+0.151,+0.150,+0.149,+0.142,+0.141,+0.140,+0.140","Skint9,Alox12e,Skint10,Ifitm6,Ncf4,Skint6,Orm1,Clec4e,Calm4,Skint5,Gm94,Tmprss4,Tesc,Il1f5,Susd2","-0.156,-0.143,-0.132,-0.126,-0.123,-0.122,-0.117,-0.115,-0.115,-0.112,-0.110,-0.107,-0.106,-0.105,-0.104"
+eccrine-ductal,eccrine-ductal,"Cyba,C1qa,Ctsz,Serpina3n,C1qc,Csf1r,Ccl11,Hexa,Ccl8,C1qb,Pcolce2,Ms4a7,Ctsh,Tmem106a,Pf4,Ccl7,Cd86,Cd302,Fcrls,Clec3b","+0.074,+0.072,+0.071,+0.070,+0.070,+0.067,+0.066,+0.065,+0.065,+0.065,+0.064,+0.064,+0.063,+0.062,+0.062,+0.061,+0.060,+0.059,+0.059,+0.059","Car3,Cox8b,Myl1,Adipoq,Acta1,Cidec,Tnnc2,Pgam2,Ckm,Mylpf,Tnnt3,Tcap,Hspb6,Atp2a1,Cox6a2","-0.091,-0.090,-0.069,-0.064,-0.064,-0.062,-0.059,-0.058,-0.057,-0.056,-0.055,-0.054,-0.054,-0.053,-0.053"
+eccrine-placode,eccrine-placode,"Car3,Cox8b,Adipoq,Cidec,Cidea,Pnpla2,Chchd10,Adig,Acta1,Myl1,Cma1,Gpd1,Lpl,Hbb-bs,Retn,Ppp1r1a,8430408G22Rik,Agt,Tpsb2,Fitm1","+0.483,+0.476,+0.409,+0.396,+0.374,+0.325,+0.307,+0.273,+0.267,+0.265,+0.262,+0.257,+0.257,+0.247,+0.241,+0.241,+0.231,+0.228,+0.228,+0.224","Tgfbi,mt-Atp6,Ctsh,Il11ra1,Gas6,Rnase4,H2-D1,Serpina3n,Ccl11,Ifi205,Il1r2,Ly6a,Lgals9,Sepp1,Cd34","-0.288,-0.279,-0.268,-0.242,-0.239,-0.235,-0.234,-0.219,-0.218,-0.214,-0.208,-0.207,-0.201,-0.199,-0.198"
+eccrine-secretory,eccrine-secretory,"Car3,Cox8b,Adipoq,Cidec,Cidea,Pnpla2,Adig,Lpl,Chchd10,Hbb-bs,Cma1,Gpd1,Ndrg2,Heyl,Tpsb2,Des,Ppp1r1a,Agt,Retn,Myl1","+0.202,+0.192,+0.179,+0.170,+0.170,+0.152,+0.136,+0.131,+0.129,+0.120,+0.119,+0.118,+0.117,+0.116,+0.108,+0.107,+0.107,+0.104,+0.104,+0.102","Tgfbi,Ckmt1,Fcgbp,Urah,Anxa8,Trp63,Ackr4,Sult5a1,Clca3a2,Gm13305,Capns2,Itgb4,Serpinb10,H2-D1,Plek2","-0.157,-0.156,-0.147,-0.144,-0.142,-0.137,-0.131,-0.128,-0.126,-0.122,-0.121,-0.120,-0.116,-0.115,-0.114"
+eden-dermal-niche,eden-dermal-niche,"Cpz,Osr2,Fxyd1,Car3,Rarres2,Cox8b,Htra3,Cyp2f2,Adamts2,Dpt,Adipoq,Lpl,Clec3b,Thy1,Serpina3c,Pcolce2,Cidec,Mmp23,Scara5,Mmp27","+0.081,+0.079,+0.074,+0.074,+0.073,+0.073,+0.071,+0.071,+0.066,+0.066,+0.065,+0.064,+0.063,+0.063,+0.063,+0.062,+0.062,+0.062,+0.062,+0.061","Hmga2,Nnat,6330403K07Rik,Marcksl1,Cnn2,Lix1,Flrt3,Cd24a,Casz1,Lsr,Tubb2b,Ly6g6e,Smagp,Sox11,Tspan13","-0.064,-0.063,-0.058,-0.058,-0.058,-0.057,-0.055,-0.055,-0.054,-0.054,-0.053,-0.053,-0.052,-0.052,-0.052"
+endothelial,endothelial,"Gpihbp1,Esam,Aplnr,Cdh5,Tie1,Icam2,C1qtnf9,Grrp1,Robo4,Tinagl1,Kdr,Gimap6,Rasip1,Arhgef15,Tmem255a,Sdpr,C130074G19Rik,Adgrf5,Emcn,Apold1","+0.193,+0.186,+0.177,+0.177,+0.176,+0.176,+0.175,+0.171,+0.170,+0.164,+0.162,+0.160,+0.159,+0.155,+0.152,+0.150,+0.149,+0.148,+0.146,+0.146","Lilrb4a,Lilr4b,Clec4e,Spi1,Plek,Cd14,Cd68,Alox5ap,Nlrp3,Clec4d,Ms4a6c,Ptafr,Ctss,Tyrobp,Cfp","-0.129,-0.109,-0.109,-0.108,-0.107,-0.106,-0.104,-0.104,-0.103,-0.102,-0.102,-0.102,-0.100,-0.099,-0.099"
+fibroblast,fibroblast,"Adipoq,Cidec,Car3,Cox8b,Lpl,Cidea,Pnpla2,Adig,Chchd10,Agt,Gpx3,Gpd1,Ppp1r1a,Retn,Mrap,Cma1,Tpsb2,Fxyd1,Cpa3,Atp1a2","+0.029,+0.028,+0.026,+0.025,+0.024,+0.022,+0.020,+0.020,+0.018,+0.018,+0.018,+0.018,+0.018,+0.017,+0.016,+0.016,+0.015,+0.014,+0.013,+0.013","Lhx2,Alcam,Trp63,Bcam,Lmo1,Ptn,Smoc2,Fermt1,Nfib,Hoxc13,Reep4,Net1,Sostdc1,Ajuba,Igsf9","-0.027,-0.020,-0.019,-0.019,-0.019,-0.018,-0.017,-0.017,-0.017,-0.017,-0.017,-0.016,-0.016,-0.016,-0.016"
+fibroblast-papillary,fibroblast-papillary,"Akr1c18,Rarres2,Krt79,Prlr,Fxyd1,Serpina3n,S100a1,Cdkn2c,Gstm1,Htra3,Aadac,Ifi205,C1ra,Ccl11,Has1,Mmp23,Zbtb20,Ctsh,Ccl7,Serpinb6a","+0.160,+0.155,+0.154,+0.150,+0.147,+0.143,+0.142,+0.141,+0.140,+0.138,+0.135,+0.133,+0.131,+0.129,+0.129,+0.129,+0.128,+0.128,+0.127,+0.127","Hba-a1,Hba-a2,Igf2,Hbb-bt,Hbb-bs,Nnat,Mest,Agtr2,Cma1,Cpa3,6330403K07Rik,Tpsb2,Actc1,Dlk1,Lix1","-0.226,-0.207,-0.201,-0.190,-0.184,-0.178,-0.170,-0.169,-0.149,-0.142,-0.139,-0.139,-0.136,-0.135,-0.129"
+fibroblast-reticular,fibroblast-reticular,"Mest,Dlk1,Igf2,Maged2,Peg3,Twist2,Osr1,Crabp1,Cdkn1c,Ndn,Agtr2,Col26a1,Pth1r,Nrp1,H19,Gpx7,Efemp2,Mdk,Gpc3,Fbn2","+0.719,+0.687,+0.685,+0.676,+0.668,+0.653,+0.638,+0.636,+0.633,+0.633,+0.633,+0.625,+0.611,+0.606,+0.605,+0.602,+0.602,+0.600,+0.598,+0.594","Anxa8,H2-D1,H2-K1,Urah,Pkib,Fam25c,Ckmt1,Capns2,Calm5,Trp63,Calm4,Clca3a2,Gata3,H2-Aa,Mt1","-0.442,-0.438,-0.430,-0.404,-0.378,-0.375,-0.369,-0.336,-0.318,-0.318,-0.312,-0.311,-0.306,-0.305,-0.304"
+granular,granular,"Htra3,Serpina3n,Cd302,Cd34,Olfml3,Selm,Col5a2,Mfap2,Cyp26b1,Rarres2,Ccl11,Aebp1,Rcn3,Dpep1,Dclk1,Timp2,Serping1,Clec3b,Adamts2,Serpinf1","+0.096,+0.094,+0.093,+0.091,+0.089,+0.088,+0.085,+0.085,+0.083,+0.083,+0.083,+0.083,+0.082,+0.082,+0.081,+0.081,+0.079,+0.079,+0.079,+0.078","Fcgbp,Slco2a1,Tnfrsf18,Il33,Cbr2,Wnt10a,1810011O10Rik,Crlf1,Clca3a2,Ckmt1,Slc6a4,Urah,Bcam,Cfap57,Gm13305","-0.105,-0.087,-0.081,-0.079,-0.077,-0.076,-0.074,-0.073,-0.072,-0.072,-0.070,-0.070,-0.069,-0.067,-0.066"
+hair-placode,hair-placode,"Cox8b,Car3,Adipoq,Cidec,Cidea,Chchd10,Pnpla2,Cma1,Lpl,Tpsb2,Adig,Acta1,Gpd1,Myl1,8430408G22Rik,Hbb-bs,Ppp1r1a,Cpa3,Retn,Gpx3","+0.522,+0.510,+0.440,+0.433,+0.419,+0.351,+0.349,+0.343,+0.307,+0.304,+0.297,+0.292,+0.273,+0.265,+0.263,+0.261,+0.261,+0.259,+0.258,+0.241","Tgfbi,mt-Atp6,Il11ra1,Ctsh,Cd34,Gas6,Rnase4,Lhx2,Lgals9,Sostdc1,Selm,H2-D1,Sepp1,AI607873,Il1r2","-0.323,-0.315,-0.294,-0.288,-0.265,-0.260,-0.247,-0.246,-0.245,-0.244,-0.241,-0.239,-0.237,-0.233,-0.232"
+immune,immune,"Fcgrt,Rcn3,Cd34,Pcolce,Rarres2,Htra3,H2-DMb2,Dpep1,Cpz,Plpp3,Fxyd1,Osr2,Bgn,Cd302,Adamts2,Serpinh1,Mfap2,Ppic,Fkbp7,Olfml3","+0.074,+0.067,+0.066,+0.065,+0.064,+0.063,+0.062,+0.061,+0.061,+0.061,+0.061,+0.061,+0.061,+0.060,+0.060,+0.059,+0.058,+0.058,+0.057,+0.057","Fam25c,Anxa8,Dsg1a,Calm5,Gata3,Alox12e,Calm4,Urah,Susd2,Ikzf2,Clca3a2,Ckmt1,Oas1f,Capns2,Clec4e","-0.078,-0.073,-0.070,-0.066,-0.062,-0.062,-0.060,-0.060,-0.059,-0.057,-0.057,-0.057,-0.056,-0.056,-0.055"
+melanocyte,melanocyte,"Mcoln3,Npy,Tyr,Pax3,Slc45a2,Glrb,Syngr1,Trpm1,Syt4,Mitf,Kit,Gucy1b3,Gsta1,Slc26a7,Mgll,Sox10,Akr1c18,Cpne4,Synpr,Tspan10","+0.157,+0.144,+0.134,+0.133,+0.131,+0.125,+0.118,+0.113,+0.112,+0.105,+0.104,+0.101,+0.099,+0.091,+0.085,+0.084,+0.082,+0.080,+0.079,+0.078","Reln,Saa3,Egfl8,Sostdc1,Hp,Tnc,Prox1,Gldn,Serpina3g,Ttyh1,Kcna1,Gfra3,Plekhb1,Srpx2,Cadm4","-0.089,-0.077,-0.065,-0.063,-0.062,-0.062,-0.062,-0.061,-0.058,-0.058,-0.057,-0.056,-0.054,-0.054,-0.054"
+nascent-eccrine-gland,nascent-eccrine-gland,"Car3,Cox8b,Adipoq,Cidec,Cidea,Chchd10,Pnpla2,Myl1,Acta1,Adig,Gpd1,Tnnc2,Pgam2,Ckm,Fitm1,Ppp1r1a,Retn,Atp2a1,Mylpf,Tnnt3","+0.942,+0.941,+0.745,+0.729,+0.697,+0.606,+0.605,+0.603,+0.588,+0.509,+0.492,+0.484,+0.470,+0.465,+0.462,+0.443,+0.440,+0.438,+0.437,+0.435","Ctsh,Tgfbi,mt-Atp6,Il11ra1,Rnase4,Lgals9,Ifi204,Selm,Ctsz,Ccl11,Serpina3n,AI607873,Sepp1,Cd34,Gas6","-0.577,-0.511,-0.493,-0.490,-0.475,-0.474,-0.467,-0.465,-0.465,-0.463,-0.456,-0.456,-0.434,-0.432,-0.429"
+sebaceous,sebaceous,"Defb6,Krt79,H2-M2,Cd207,mt-Atp6,H2-DMb2,Dapk2,Cd72,Aadac,Aldh3a1,Gata6,H2-DMb1,H2-K1,Ltc4s,Dpep2,Tgfbi,Xlr,Cd86,Fcgbp,Rgs10","+0.589,+0.546,+0.476,+0.453,+0.442,+0.439,+0.439,+0.437,+0.433,+0.425,+0.404,+0.395,+0.390,+0.388,+0.388,+0.386,+0.385,+0.380,+0.378,+0.377","Cox8b,Car3,Adipoq,Cidec,Hbb-bs,Cidea,Gpx3,Hba-a1,Notum,Cpne5,Chchd10,Cma1,Pnpla2,Lef1,Smoc1","-0.705,-0.604,-0.552,-0.543,-0.534,-0.527,-0.513,-0.470,-0.469,-0.458,-0.453,-0.448,-0.423,-0.421,-0.409"
+spinous,spinous,"Hexa,Csf1r,Cyba,AI607873,Emp3,Zeb2,Cd302,Fcer1g,C1qa,Adgre1,Ccl11,C1qc,Serpina3n,Ccl7,Ctsz,C1qb,Cd34,Pf4,Fxyd5,Laptm5","+0.124,+0.122,+0.118,+0.114,+0.113,+0.111,+0.108,+0.106,+0.106,+0.105,+0.105,+0.105,+0.104,+0.103,+0.102,+0.101,+0.099,+0.098,+0.097,+0.096","Calm5,Fam25c,Anxa8,Ckmt1,Oas1f,Urah,Trp63,Capns2,Gata3,Clca3a2,Cfap57,Gdpd2,Fcgbp,Dsg1a,Bcam","-0.212,-0.194,-0.188,-0.186,-0.181,-0.177,-0.168,-0.167,-0.165,-0.157,-0.156,-0.153,-0.148,-0.144,-0.144"
+unassigned,unassigned,"Lhx2,mt-Atp6,Il11ra1,Sepp1,Ctsz,Cd34,Ctsh,Sostdc1,Selm,Pcolce2,Clec3b,Gas6,Lgals9,Tmem106a,Ccl11,Cyba,Cd302,Tgm5,Gas1,Timp2","+0.189,+0.160,+0.154,+0.154,+0.149,+0.141,+0.139,+0.138,+0.138,+0.137,+0.137,+0.136,+0.135,+0.133,+0.132,+0.131,+0.130,+0.128,+0.128,+0.127","Cox8b,Car3,Acta1,Myl1,Adipoq,Cidec,Tnnc2,Cidea,Ckm,Chchd10,Tnnt3,Pgam2,Tnni2,Mylpf,Atp2a1","-0.293,-0.279,-0.221,-0.204,-0.197,-0.197,-0.186,-0.177,-0.176,-0.172,-0.167,-0.166,-0.164,-0.163,-0.161"

discovery/80_pan_skin_pc_attribution.csv

@@ -0,0 +1,25 @@
+,PC1,PC2,PC3,PC4,PC5,PC6,PC7,PC8,PC9,PC10,PC11,PC12,PC13,PC14,PC15,PC16,PC17,PC18,PC19,PC20,PC21,PC22,PC23,PC24,PC25,PC26,PC27,PC28,PC29,PC30,PC31,PC32,PC33,PC34,PC35,PC36,PC37,PC38,PC39,PC40,PC41,PC42,PC43,PC44,PC45,PC46,PC47,PC48,PC49,PC50
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discovery/80_pan_skin_tf_enrichment.csv

@@ -0,0 +1,433 @@
+class,program,n_genes_in_hvg,sum_attribution,hit_frac_top100_pos
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discovery/80_pan_skin_top_tf_per_class.csv

@@ -0,0 +1,73 @@
+class,program,n_genes_in_hvg,sum_attribution,hit_frac_top100_pos
+HF-DP,melanocyte,6,0.34775421023368835,0.0
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+HF-placode,eccrine-placode,6,0.22261552512645721,0.0
+UNK,immune,6,1.9154421091079712,0.16666666666666666
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+UNK,spinous,4,0.11719467490911484,0.0
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+hair-placode,Merkel,6,0.06477677822113037,0.0
+immune,fibroblast-papillary,6,0.14275558292865753,0.0
+immune,fibroblast-reticular,6,0.11492003500461578,0.0
+immune,endothelial,7,0.06618095189332962,0.0
+melanocyte,melanocyte,6,0.47641733288764954,0.6666666666666666
+melanocyte,HF-ORS,8,0.05435666814446449,0.0
+melanocyte,sebaceous,7,0.05388333648443222,0.0
+nascent-eccrine-gland,sebaceous,7,1.0576790571212769,0.14285714285714285
+nascent-eccrine-gland,HF-DP,7,0.34956637024879456,0.0
+nascent-eccrine-gland,Merkel,6,0.16560950875282288,0.0
+sebaceous,HF-ORS,8,1.1943057775497437,0.0
+sebaceous,immune,6,0.5165554285049438,0.0
+sebaceous,basal-IFE,5,0.38254162669181824,0.0
+spinous,fibroblast-papillary,6,0.2335970252752304,0.16666666666666666
+spinous,immune,6,0.21748086810112,0.16666666666666666
+spinous,fibroblast-reticular,6,0.17396341264247894,0.0
+unassigned,HF-ORS,8,0.3666973114013672,0.125
+unassigned,fibroblast-papillary,6,0.30565378069877625,0.0
+unassigned,HF-placode,7,0.27154189348220825,0.0

discovery/80_pancreas_gene_attribution.csv

@@ -0,0 +1,17 @@
+class,src_corpus_class,top_pos_genes,top_pos_attribution,top_neg_genes,top_neg_attribution
+UNK,UNK,"Col1a1,Col3a1,Tcf21,Sparcl1,Col1a2,Islr,Gap43,Sfrp1,6330403K07Rik,Mfap4,Smoc2,Des,Gas1,Col6a1,Osr2,Emp3,Cmtm3,Glipr2,Tgfbi,Mfap2","+0.078,+0.076,+0.072,+0.071,+0.069,+0.064,+0.063,+0.062,+0.062,+0.061,+0.060,+0.059,+0.059,+0.058,+0.055,+0.054,+0.054,+0.054,+0.054,+0.054","Ambp,Vtn,Cldn6,P2rx1,Gc,Wfdc2,Hmga1,Phgdh,Cldn10,Homer2,Rbpjl,Serpina6,Wfdc15b,Smco4,Cpa2","-0.061,-0.059,-0.058,-0.058,-0.056,-0.056,-0.055,-0.055,-0.054,-0.053,-0.053,-0.053,-0.052,-0.052,-0.052"
+acinar,acinar,"Try10,Prss1,Ass1,Erp27,Cel,Serpini2,Aqp8,Gm10334,Arhgdig,Cela3b,Cela2a,Gm5771,Try5,Ctrb1,Dhx34,Gm15915,Spink1,Rbpjl,Prss3,Kctd14","+0.671,+0.656,+0.622,+0.588,+0.563,+0.562,+0.554,+0.540,+0.535,+0.516,+0.514,+0.512,+0.511,+0.508,+0.506,+0.500,+0.498,+0.468,+0.465,+0.459","Vim,Fscn1,1700011H14Rik,Rbp1,Ddah2,Sparc,Wnt7b,Fxyd2,Col9a1,Mdfi,Sox4,Col2a1,Ctxn1,Sox11,Hhex","-0.343,-0.331,-0.321,-0.320,-0.310,-0.298,-0.289,-0.284,-0.279,-0.275,-0.275,-0.273,-0.269,-0.262,-0.258"
+adult-alpha,adult-alpha,"Tcf21,Sparcl1,Alas2,6330403K07Rik,Hbb-y,Hba-x,Mfap2,Gap43,Mfap4,Snca,Slc4a1,Car2,Sfrp1,Trim10,Mest,Hbb-bt,Col1a1,Emilin1,Lhfp,Col3a1","+0.402,+0.386,+0.383,+0.356,+0.348,+0.331,+0.329,+0.327,+0.325,+0.321,+0.316,+0.314,+0.313,+0.309,+0.299,+0.296,+0.287,+0.287,+0.281,+0.280","Muc1,Ctrb1,Cldn10,Prss1,Nudt19,Ass1,Cldn3,Mgst1,Gsta3,Try10,Anpep,Adamts9,Bicc1,Tinagl1,Prss8","-0.624,-0.605,-0.578,-0.554,-0.553,-0.548,-0.542,-0.537,-0.532,-0.529,-0.514,-0.509,-0.506,-0.503,-0.501"
+adult-beta,adult-beta,"Alas2,Slc4a1,Car2,Snca,Trim10,Kirrel2,Hbb-bt,Hba-x,Epb42,Tubb3,Mfng,Mnx1,Hbb-bh1,Ppp1r14a,Car14,Cdc14b,Gypa,Pax4,Fscn1,E2f1","+0.323,+0.323,+0.311,+0.271,+0.271,+0.262,+0.255,+0.248,+0.246,+0.238,+0.235,+0.225,+0.224,+0.219,+0.219,+0.215,+0.210,+0.210,+0.209,+0.208","Prss1,Try10,Cdca3,Muc1,Tinagl1,Cenpf,Ccnb1,Plk1,Cdc20,Gm10334,Ass1,Tpx2,Ube2c,Anpep,Adamts9","-0.575,-0.566,-0.549,-0.508,-0.505,-0.503,-0.498,-0.497,-0.495,-0.490,-0.489,-0.488,-0.486,-0.482,-0.476"
+alpha,alpha,"Cck,Igfbpl1,Gfra3,Vwa5b2,Arx,Btbd17,Rph3al,Mfng,Ppp1r14a,Irx2,Sct,Neurog3,Tubb3,Sult2b1,Hpca,Tmem27,Pax4,Irx1,Neurod2,Rbfox3","+0.321,+0.299,+0.272,+0.268,+0.264,+0.260,+0.244,+0.242,+0.237,+0.233,+0.229,+0.228,+0.227,+0.224,+0.223,+0.219,+0.217,+0.215,+0.212,+0.211","Ptn,Col1a1,Col3a1,Gas1,Lgals1,Col6a1,Sparcl1,Col1a2,Lum,Anxa2,Islr,Mest,Igfbp4,Vim,Cxcl12","-0.233,-0.211,-0.208,-0.193,-0.190,-0.187,-0.186,-0.180,-0.179,-0.179,-0.178,-0.177,-0.173,-0.169,-0.165"
+beta,beta,"Pax4,Gfra3,Slc4a1,Tubb3,Vwa5b2,Fev,Neurog3,Mfng,Alas2,Rph3al,Cck,Igfbpl1,Btbd17,Trim10,Car2,Pde1c,Gm8773,Snca,Tox3,Gadd45a","+0.401,+0.362,+0.357,+0.357,+0.334,+0.327,+0.324,+0.304,+0.304,+0.296,+0.295,+0.294,+0.292,+0.292,+0.291,+0.278,+0.277,+0.272,+0.271,+0.267","2810417H13Rik,Birc5,Cdk1,Top2a,Spc24,Cdca3,Ccna2,Cdca8,Aurkb,Pbk,Tyms,Tk1,Smc4,Cldn10,Cenpm","-0.403,-0.387,-0.367,-0.366,-0.366,-0.361,-0.352,-0.346,-0.346,-0.342,-0.335,-0.331,-0.331,-0.329,-0.326"
+delta,delta,"Col1a1,Mfap4,Tcf21,Sparcl1,Col3a1,Col1a2,6330403K07Rik,Islr,Sfrp1,Mfap2,Col6a1,Lum,Fstl1,Basp1,Smoc2,Nkain4,Cmtm3,Gap43,Des,Col6a2","+0.575,+0.566,+0.549,+0.545,+0.545,+0.510,+0.498,+0.490,+0.461,+0.449,+0.447,+0.431,+0.423,+0.408,+0.407,+0.405,+0.404,+0.395,+0.384,+0.382","Cldn10,Phgdh,Ctrb1,Cpa2,Rbpjl,Cpa1,Clps,Bex4,Spink1,Smco4,Wfdc15b,Gamt,Cel,Pnliprp1,Mgst1","-0.644,-0.594,-0.582,-0.577,-0.577,-0.549,-0.543,-0.539,-0.538,-0.538,-0.535,-0.533,-0.533,-0.518,-0.515"
+ductal,ductal,"Tubb2b,Igfbp2,Ung,Igfbp4,Ccne1,Rtn1,E2f1,Pcbp4,Irx2,BC048546,Pcna,Slc9a3r1,Gm266,Mcm5,Agtr2,Mcm3,Ndn,Arx,Rpa2,Ccne2","+0.169,+0.165,+0.161,+0.145,+0.145,+0.145,+0.139,+0.138,+0.136,+0.135,+0.133,+0.131,+0.130,+0.130,+0.129,+0.129,+0.128,+0.128,+0.128,+0.127","Alas2,Nusap1,Grin3a,Hba-x,Car2,Trim10,Snca,Slc4a1,Hbb-bh1,Cenpe,Tmem171,Aurka,Cenpf,Hbb-bt,Tinagl1","-0.126,-0.114,-0.111,-0.109,-0.107,-0.101,-0.101,-0.098,-0.097,-0.093,-0.092,-0.091,-0.091,-0.089,-0.088"
+endocrine-progenitor,endocrine-progenitor,"Alas2,Car2,Snca,Trim10,Slc4a1,Hba-x,Hbb-bt,Hbb-y,Hbb-bh1,Tmem27,Gypa,Onecut2,Hbq1b,6330403K07Rik,Hsd3b6,Basp1,Mfap2,Tuba1a,BC048546,Fev","+0.414,+0.375,+0.363,+0.346,+0.333,+0.331,+0.312,+0.307,+0.289,+0.275,+0.270,+0.252,+0.249,+0.240,+0.238,+0.220,+0.210,+0.204,+0.200,+0.190","Ctrb1,Cldn10,Prss1,Try10,Adamts9,Spink1,Cel,Serpini2,Gm10334,Bst2,Erp27,Pnliprp1,Aldh1b1,Muc1,Clps","-0.638,-0.622,-0.576,-0.573,-0.569,-0.548,-0.548,-0.540,-0.538,-0.526,-0.521,-0.516,-0.505,-0.505,-0.494"
+endothelial,endothelial,"Cdh5,Gimap6,Icam2,Esam,Pecam1,Ecscr,Myct1,Gimap4,Cldn5,Clec14a,Aplnr,Fabp4,Eng,Col4a1,Tmem204,Cd34,Col15a1,Madcam1,Emcn,Gimap5","+0.749,+0.740,+0.735,+0.712,+0.708,+0.669,+0.652,+0.639,+0.636,+0.629,+0.589,+0.559,+0.540,+0.523,+0.508,+0.497,+0.494,+0.492,+0.489,+0.489","Fcrls,Csf1r,Ly86,Trem2,Mrc1,Adgre1,Pf4,Cx3cr1,Aif1,Hist1h2ap,Ms4a6b,Igf1,Sfrp2,Ccl24,P2ry6","-0.314,-0.271,-0.265,-0.256,-0.255,-0.253,-0.251,-0.244,-0.240,-0.231,-0.226,-0.225,-0.225,-0.223,-0.217"
+epsilon,epsilon,"Arx,U2af1l4,Tcf21,Mfap4,Gm266,Tgfbi,Sfrp1,Gap43,F2r,Ctxn2,Lpar1,6330403K07Rik,Hbb-y,Capn6,Irx2,Scin,Tac2,Bambi,Ldhb,Mfap2","+0.293,+0.272,+0.254,+0.249,+0.238,+0.218,+0.201,+0.200,+0.199,+0.195,+0.194,+0.194,+0.182,+0.181,+0.179,+0.176,+0.175,+0.170,+0.164,+0.163","Serpina1c,Serpina1e,Mnx1,Gm2694,Adra2a,Serpina1b,Pabpn1l,Ube2s,Serpina1a,Mapt,Cbx3,Pgam1,Ctrb1,Rangrf,Npepl1","-0.425,-0.423,-0.396,-0.334,-0.299,-0.297,-0.272,-0.271,-0.270,-0.263,-0.257,-0.253,-0.249,-0.235,-0.235"
+gamma,gamma,"Col3a1,Col1a1,Sparcl1,Col1a2,Tcf21,Cnn2,Sfrp1,Lgals1,Lhfp,Gas1,Bgn,Col6a1,6330403K07Rik,Cmtm3,Glipr2,Emp3,Des,Rcn3,Nkain4,Fstl1","+0.320,+0.313,+0.297,+0.281,+0.273,+0.267,+0.254,+0.252,+0.247,+0.246,+0.239,+0.237,+0.237,+0.236,+0.235,+0.234,+0.232,+0.231,+0.230,+0.224","Pdx1,Tubb3,Mnx1,Ambp,Cldn6,Nkx6-1,Npepl1,Neurod2,1700086L19Rik,Sult2b1,Gfra3,Mia,Nkx2-2,Pax4,Vwa5b2","-0.252,-0.249,-0.214,-0.212,-0.209,-0.208,-0.208,-0.202,-0.197,-0.196,-0.195,-0.194,-0.193,-0.193,-0.191"
+immune,immune,"Rac2,Ly86,Fcgr3,Coro1a,Spi1,Arhgdib,Csf1r,Evi2a,Adgre1,AB124611,Clec4a2,Tnfaip8l2,Bin2,Lcp1,Cd53,Laptm5,Ncf2,Trem2,Cx3cr1,Ms4a6c","+0.848,+0.848,+0.827,+0.809,+0.780,+0.757,+0.751,+0.745,+0.742,+0.723,+0.691,+0.689,+0.685,+0.683,+0.682,+0.681,+0.672,+0.670,+0.670,+0.662","Mfap4,Mest,Dlk1,Mfap2,Mdk,Ptn,Tcf21,Ndn,Dbn1,Runx1t1,Cdkn1c,Cck,Fbln1,Col1a1,6330403K07Rik","-0.403,-0.395,-0.375,-0.356,-0.345,-0.330,-0.301,-0.300,-0.295,-0.295,-0.295,-0.290,-0.288,-0.287,-0.287"
+mesenchymal,mesenchymal,"Serpina1e,Serpina1c,Hmga1,Vtn,Pgam1,Gc,Hist1h2ap,Serpina1b,Matn4,Ube2i,P2rx1,Zfos1,Myc,Stmn1,Rbpjl,Fermt1,Chst2,Ube2s,Noxa1,Bmp7","+0.484,+0.474,+0.439,+0.433,+0.405,+0.392,+0.378,+0.378,+0.377,+0.372,+0.368,+0.354,+0.345,+0.342,+0.342,+0.341,+0.338,+0.338,+0.335,+0.332","Tcf21,Sfrp1,Cxcl12,Mfap4,6330403K07Rik,Tgfbi,Sparcl1,Nefl,Tac2,Gap43,Hoxa5,Smoc2,Adrb3,Ldb2,F2r","-0.582,-0.511,-0.478,-0.438,-0.437,-0.434,-0.415,-0.411,-0.407,-0.387,-0.370,-0.364,-0.362,-0.362,-0.354"
+other,other,"Tcf21,Sparcl1,6330403K07Rik,Col1a1,Sfrp1,Col3a1,Mfap4,Islr,Col1a2,Gap43,Mfap2,Nkain4,Tgfbi,Hic1,Emilin1,Hbb-y,Des,Nefl,Alas2,Ldb2","+0.970,+0.863,+0.850,+0.838,+0.783,+0.779,+0.765,+0.728,+0.727,+0.704,+0.675,+0.634,+0.624,+0.619,+0.605,+0.604,+0.598,+0.595,+0.589,+0.584","Cldn10,Ctrb1,Phgdh,Aldh1b1,Clps,Mgst1,Muc1,Ube2i,Wfdc15b,Nudt19,Akr1c19,Ube2s,Cldn6,Cpa2,Ambp","-1.038,-1.020,-0.919,-0.905,-0.904,-0.904,-0.903,-0.896,-0.892,-0.890,-0.886,-0.880,-0.873,-0.863,-0.861"
+unassigned,unassigned,"Mest,Igfbp4,Chst2,Car14,Ung,Vtn,Ccne1,Myc,Hmga1,Fscn1,Jag1,Matn4,Mfap2,Sparcl1,Nrp1,Etv4,Nkx6-2,Tuba1a,6330403K07Rik,Nsg1","+0.905,+0.760,+0.750,+0.741,+0.739,+0.707,+0.641,+0.583,+0.582,+0.579,+0.570,+0.546,+0.536,+0.533,+0.515,+0.513,+0.511,+0.509,+0.507,+0.486","Tinagl1,Col9a3,Dcdc2a,Gpx2,Ppp1r1b,Grin3a,Pdzk1ip1,Prss1,Neurog3,Bicc1,Try10,Lurap1l,Muc1,Kctd14,Krt19","-1.040,-0.892,-0.858,-0.839,-0.774,-0.770,-0.757,-0.751,-0.727,-0.717,-0.715,-0.715,-0.702,-0.689,-0.689"

discovery/80_pancreas_pc_attribution.csv

@@ -0,0 +1,17 @@
+,PC1,PC2,PC3,PC4,PC5,PC6,PC7,PC8,PC9,PC10,PC11,PC12,PC13,PC14,PC15,PC16,PC17,PC18,PC19,PC20,PC21,PC22,PC23,PC24,PC25,PC26,PC27,PC28,PC29,PC30,PC31,PC32,PC33,PC34,PC35,PC36,PC37,PC38,PC39,PC40,PC41,PC42,PC43,PC44,PC45,PC46,PC47,PC48,PC49,PC50
+UNK,0.9111654,-0.18778072,-0.014892561,-0.0005203958,0.109983094,0.013417845,0.0034729263,0.09117138,0.002488611,-0.05374598,-0.029694129,-0.041449606,-0.00076604803,0.010026114,0.0519065,0.0057454742,0.000771698,-0.0041083675,-0.05054685,0.05386866,0.017079677,-0.008951487,0.012364681,0.024594681,0.044327524,0.010177623,0.0408612,0.02870529,-0.0042091995,-0.0140737565,0.0021418466,-0.013491149,-0.0027508836,-0.00053134846,0.016504856,-0.009316479,-0.0038039114,0.02491694,0.004896215,0.0029404634,-0.0038626948,0.05076111,0.022781745,-0.003521505,0.0062198346,0.0042722193,0.027922215,-0.0032040218,-0.012346163,0.009124688
+acinar,-1.3717577,0.5838035,4.965219,0.07210898,0.009010156,0.13806906,0.15095761,1.487146,-0.028632713,-0.095505245,0.14324002,0.04687575,-0.024179488,0.014137538,0.41163105,0.44282565,-0.008910075,0.02323492,-0.04267457,0.0051682824,0.0070608878,0.08533385,-0.056891408,0.031804934,0.020334171,-0.0076411576,0.038663857,0.15651964,-0.016550217,0.0011419373,0.011767223,0.104475036,0.01855252,0.081691146,-0.00011279189,0.00673522,0.028522681,-0.024898326,-0.011711544,-0.1136437,-0.008420293,-0.015503164,0.07480862,-0.16654557,-0.014663928,-0.026596835,-0.0098888,0.13714947,0.008520931,0.00039040842
+adult-alpha,7.1177483,0.3430677,0.46158424,-0.60128057,-0.21162848,-0.5781805,0.9916056,-4.7180066,0.013530693,-0.07309347,0.43627346,0.30235532,0.6550105,-0.37800607,-0.02104711,-0.16092151,0.38066837,-0.08324706,0.03883166,0.10010477,0.21830429,0.0617302,0.007947645,0.0093073975,-0.36261177,-0.030723996,-0.20307139,-0.05941691,0.21430406,0.008809237,0.034077287,-0.53837925,0.03915466,-0.0344955,-0.06179315,-0.12180726,-0.009913426,-0.05763655,0.34956628,0.054655444,0.03870961,0.16997613,0.17279693,-0.078297384,-0.004089144,0.26534522,0.16579287,-0.012541502,-0.06533642,-0.11218327
+adult-beta,5.245487,2.0136478,0.18573803,0.7036466,-0.5741605,0.43549547,2.4032166,-3.7684538,0.09952124,0.13633461,1.8152635,0.09298759,0.3339797,-0.0692969,-0.18595931,-0.0868884,-0.89834064,-0.027560078,0.058960274,0.02653558,-0.35170823,0.09491737,-0.011297314,-0.09988563,-0.26860216,-0.065229185,-0.458427,-0.0009818209,0.24458213,-0.15325256,-0.0032772312,-0.079722695,0.25182945,-0.106180884,-0.048268653,0.011192226,0.046376057,-0.009759966,-0.022141136,-0.060755286,0.08120057,0.020657493,0.03551843,-0.14178085,0.10556926,0.11554934,0.029635428,0.004439277,0.0499622,0.037359163
+alpha,-0.0029060997,3.2969797,0.09526153,-0.09248138,0.056785606,0.3412592,0.00067707535,-0.50404274,0.066254064,-0.03633114,-0.111528195,-0.026569657,0.55728006,0.001225761,0.14314899,0.018767366,0.32173663,0.00045708526,-0.0054487223,-0.0051479423,0.10803333,0.04730371,-0.03862223,-0.014975717,0.03382707,0.008752008,-0.0495412,0.04175934,0.042448837,0.020471754,0.044800956,-7.0799542e-06,-0.00023206581,0.00609493,0.005759919,-0.014443189,-0.025843576,0.003984199,0.0034585672,-0.14739904,-0.015922304,0.001269855,-0.0014961056,-0.0033075167,-0.00023574255,0.04012197,0.0071424046,0.00020330348,-0.030894468,-0.00031053004
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discovery/80_pancreas_tf_enrichment.csv

@@ -0,0 +1,161 @@
+class,program,n_genes_in_hvg,sum_attribution,hit_frac_top100_pos
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discovery/80_pancreas_top_tf_per_class.csv

@@ -0,0 +1,49 @@
+class,program,n_genes_in_hvg,sum_attribution,hit_frac_top100_pos
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+ductal,delta,4,0.10153404623270035,0.0
+endocrine-progenitor,alpha,6,0.5775297284126282,0.3333333333333333
+endocrine-progenitor,endothelial,5,0.17085771262645721,0.0
+endocrine-progenitor,endocrine-progenitor,6,0.11762605607509613,0.16666666666666666
+endothelial,endothelial,5,2.506868839263916,0.6
+endothelial,endocrine-progenitor,6,0.07675479352474213,0.0
+endothelial,alpha,6,0.073072649538517,0.0
+epsilon,alpha,6,0.5119960904121399,0.5
+epsilon,epsilon,2,0.15962940454483032,0.5
+epsilon,endothelial,5,0.06981838494539261,0.0
+gamma,endothelial,5,0.19600346684455872,0.0
+gamma,alpha,6,0.14916381239891052,0.0
+gamma,epsilon,2,0.08503416180610657,0.0
+immune,immune,5,1.4533421993255615,0.2
+immune,endothelial,5,0.3463759422302246,0.0
+immune,ductal,5,0.24533677101135254,0.0
+mesenchymal,ductal,5,0.7839223742485046,0.0
+mesenchymal,acinar,5,0.735937774181366,0.0
+mesenchymal,delta,4,0.5681240558624268,0.0
+other,endothelial,5,0.365139365196228,0.0
+other,gamma,3,-0.16978174448013306,0.0
+other,alpha,6,-0.18785139918327332,0.0
+unassigned,endothelial,5,0.5184568762779236,0.0
+unassigned,alpha,6,0.2567732036113739,0.0
+unassigned,delta,4,0.11201924085617065,0.0

discovery/81_hematopoiesis_ko_essentials.csv

@@ -0,0 +1,9 @@
+class,baseline_cos,n_cells_class,top_essential_genes,top_essential_deltas,top_essential_baseline_expression
+MPP,4.287202835083008,72192,"Elane,Mmp8,Mllt3,Car2,Pf4,Wfdc17,Csf1r,Meis1,Dntt,Gata1,Gp1bb,Flt3,2017_9_CD45minus_TTTGGTTAGCTACCTA,2017_9_CD45minus_GGGCATCGTCATTAGC,2017_9_CD45minus_GCGCGATGTGCGCTTG,2017_9_CD45minus_TACCTATCAAGACACG,2017_9_CD45minus_TTGGCAATCCTAAGTG,2017_9_CD45minus_TGCCCATAGGCGTACA,2017_9_CD45minus_TGCTACCCACAGTCGC,2017_9_CD45minus_TAGTTGGAGATCCTGT","+0.6533,+0.4135,+0.1307,+0.1245,+0.1019,+0.0550,+0.0349,+0.0327,+0.0137,+0.0124,+0.0025,+0.0004,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","3.27,1.01,0.46,1.21,0.98,0.69,0.80,0.94,0.18,0.33,0.03,0.54,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00"
+UNK,3.5341317653656006,101,"Sell,Ctss,Il7r,Pf4,Flt3,Mmp8,Gp1bb,Cd48,Mllt3,Wfdc17,Meis1,Cpa3,Gata1,Car2,Csf1r,Itga2b,Vpreb3,Ms4a2,Hlf,Klf1","+2.4343,+1.0430,+0.8756,+0.0993,+0.0880,+0.0741,+0.0693,+0.0660,+0.0325,+0.0296,+0.0234,+0.0194,+0.0181,+0.0105,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","5.37,4.48,1.45,0.47,2.00,0.32,0.08,2.00,0.33,0.40,0.65,0.23,0.07,0.09,0.00,0.00,0.00,0.00,0.00,0.00"
+basophil-mast,7.2551140785217285,12739,"Cpa3,Pf4,Itga2b,Gata1,Il7r,Sell,Wfdc17,Mmp8,Csf1r,Gp1bb,Meis1,Klf1,Slamf1,Ctss,Elane,Hba-a1,Procr,Vpreb3,Flt3,Fgd5","+1.7463,+0.1094,+0.0842,+0.0699,+0.0512,+0.0438,+0.0108,+0.0072,+0.0069,+0.0057,+0.0057,+0.0054,+0.0054,+0.0041,+0.0030,+0.0015,+0.0006,+0.0003,+0.0001,+0.0001","8.08,1.62,3.80,1.74,0.33,0.62,0.15,0.34,0.14,0.03,0.33,0.07,0.20,0.13,0.35,0.01,0.02,0.00,0.05,0.00"
+erythroid,3.5817484855651855,686,"Hba-a1,Pf4,Car2,Mllt3,Gata1,Gp1bb,Elane,Mmp8,Wfdc17,Ctss,Fgd5,2017_9_CD45minus_TTTGGTTAGCTACCTA,Dntt,Il7r,2017_9_CD45minus_GGGCATCGTCATTAGC,Vpreb3,2017_9_CD45minus_GCGCGATGTGCGCTTG,2017_9_totalBM_ACATACGGTAAGGGAA,2017_9_CD45minus_TAGTTGGAGATCCTGT,2017_9_CD45minus_GGCAATTCACGGCTAC","+0.2056,+0.0345,+0.0237,+0.0153,+0.0105,+0.0065,+0.0016,+0.0008,+0.0007,+0.0003,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","2.52,2.66,7.30,2.17,3.53,0.19,0.30,0.16,0.13,0.06,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00"
+lymphoid,4.114984035491943,857,"Ctss,Il7r,Dntt,Sell,Cpa3,Wfdc17,Pf4,Mmp8,Procr,Fgd5,Car1,Ms4a2,Gata1,Gp1bb,2017_9_CD45minus_GGGCATCGTCATTAGC,2017_9_CD45minus_TTTGGTTAGCTACCTA,2017_9_CD45minus_TACTTACAGTATTGGA,Vpreb3,Hba-a1,2017_9_CD45minus_GGCAATTCACGGCTAC","+0.1497,+0.0940,+0.0646,+0.0624,+0.0549,+0.0129,+0.0095,+0.0071,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","1.48,0.33,2.05,0.96,0.58,0.28,0.16,0.09,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00"
+megakaryocyte,6.305171966552734,2096,"Pf4,Gp1bb,Itga2b,Gata1,Sell,Cpa3,Ms4a2,Mllt3,Ctss,Mmp8,Wfdc17,Il7r,Hlf,Mecom,2017_9_CD45minus_GTACTCCAGAGCAATT,Fgd5,2017_9_CD45minus_GTGCGGTTCTTCATGT,2017_9_CD45minus_GGACATTTCCAATGGT,2017_9_CD45minus_TCACGAAGTTGACGTT,2017_9_CD45minus_TGAGGGACAATACGCT","+0.2955,+0.0392,+0.0299,+0.0151,+0.0085,+0.0068,+0.0020,+0.0015,+0.0005,+0.0004,+0.0004,+0.0002,+0.0001,+0.0001,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","8.09,2.49,6.72,3.63,1.14,1.07,0.21,0.62,0.23,0.32,0.40,0.03,0.05,0.01,0.00,0.00,0.00,0.00,0.00,0.00"
+myeloid,5.132401466369629,42210,"Mmp8,Csf1r,Mpo,Elane,Procr,Car2,Mllt3,Meis1,Gp1bb,Klf1,Ms4a2,Car1,Dntt,2017_9_CD45minus_TACTTACAGTATTGGA,2017_9_CD45minus_TTTGGTTAGCTACCTA,2017_9_CD45minus_GGGCATCGTCATTAGC,2017_9_CD45minus_TACCTATCAAGACACG,2017_9_CD45minus_TTGGCAATCCTAAGTG,2017_9_CD45minus_TGCCCATAGGCGTACA,2017_9_CD45minus_GGCAATTCACGGCTAC","+1.2054,+0.5166,+0.0950,+0.0521,+0.0173,+0.0145,+0.0090,+0.0084,+0.0078,+0.0036,+0.0014,+0.0007,+0.0002,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","3.78,2.06,2.28,3.74,0.23,0.26,0.17,0.11,0.06,0.01,0.13,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00"
+unassigned,4.991764068603516,9497,"2017_9_CD45minus_TAAGCGTAGGCGACAT,2017_9_CD45minus_TCACAAGGTGTCAATC,2017_9_CD45minus_GGGCATCGTCATTAGC,2017_9_CD45minus_TAGACCATCTTGCAAG,2017_9_CD45minus_TGTTCCGGTACTCAAC,2017_9_CD45minus_TTCTCCTTCCGCAAGC,2017_9_CD45minus_TTGTAGGTCAATAAGG,2017_9_CD45minus_GGATGTTCACCCAGTG,2017_9_CD45minus_GCGGGTTCAATCACAC,2017_9_CD45minus_GTAGGCCGTTCACGGC,2017_9_CD45minus_GCGCGATGTGCGCTTG,2017_9_CD45minus_GGATGTTCATGCAACT,2017_9_totalBM_ACGGGCTCAAGTTGTC,2017_9_CD45minus_GGTGAAGTCGGGAGTA,2017_9_totalBM_ACATACGCAATGTAAG,2017_9_CD45minus_TCATTACGTCCTCCAT,2017_9_CD45minus_GGAGCAATCATGTGGT,2017_9_CD45minus_TCGAGGCTCTATCCTA,2017_9_CD45minus_TGCCCATCAGATGGGT,2017_9_CD45minus_TTAACTCTCTGGAGCC","+0.0045,+0.0029,+0.0027,+0.0020,+0.0019,+0.0019,+0.0018,+0.0016,+0.0016,+0.0015,+0.0015,+0.0014,+0.0014,+0.0014,+0.0014,+0.0014,+0.0013,+0.0012,+0.0011,+0.0010","1.03,1.07,0.94,0.96,0.85,0.94,0.99,0.91,0.99,1.00,0.82,1.14,0.76,0.94,0.76,1.01,1.07,1.01,0.99,1.01"

discovery/81_pan_skin_ko_essentials.csv

@@ -0,0 +1,25 @@
+class,baseline_cos,n_cells_class,top_essential_genes,top_essential_deltas,top_essential_baseline_expression
+HF-DP,5.167459487915039,330,"Bmp3,Enpp2,Edn3,Notum,Lrrn1,Wnt5a,Dll1,Col23a1,Itih5,C1qtnf6,C1qtnf2,Plod1,Ddah1,Matn2,Sobp,Wif1,Igsf10,Vstm4,Mmp23,Lamc3","+0.0019,+0.0014,+0.0009,+0.0009,+0.0006,+0.0006,+0.0006,+0.0004,+0.0003,+0.0003,+0.0003,+0.0002,+0.0002,+0.0002,+0.0002,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001","2.51,2.16,1.87,1.06,2.08,2.20,1.52,2.44,1.97,1.38,1.33,0.59,1.23,1.11,1.68,2.44,0.61,0.69,0.64,1.40"
+HF-ORS,6.869032859802246,607,"Ank,Gm94,Kdm6b,Pim1,Kctd12,Gsta2,Gm2a,Zfp750,Skint6,Tprg,Hexa,Sepp1,Cidea,Cdc20,Cyba,Tnip3,Lockd,Cybb,Adgre1,Gm6377","+0.0116,+0.0035,+0.0016,+0.0012,+0.0009,+0.0007,+0.0007,+0.0004,+0.0003,+0.0003,+0.0002,+0.0002,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","1.46,0.79,1.22,1.47,0.60,0.08,0.35,0.86,0.32,0.40,0.18,0.63,0.04,0.03,0.07,0.01,0.02,0.02,0.00,0.00"
+HF-placode,5.512970924377441,3082,"Avpi1,Tgif1,Serpinb10,Moxd1,Net1,Ctnnal1,Wnt10a,Itgb4,F11r,Tenm2,Cdh3,Epcam,Shmt1,Npnt,Lamc2,Cadm1,Smoc2,Sult5a1,Tfap2a,2010111I01Rik","+0.0016,+0.0015,+0.0014,+0.0012,+0.0011,+0.0010,+0.0009,+0.0008,+0.0007,+0.0007,+0.0007,+0.0006,+0.0006,+0.0006,+0.0006,+0.0006,+0.0005,+0.0005,+0.0005,+0.0004","1.52,2.08,1.47,1.44,2.67,1.26,1.41,1.19,1.63,1.65,2.35,2.93,1.90,1.27,1.08,2.51,2.68,1.28,2.22,1.43"
+UNK,6.316054344177246,3174,"Amica1,Ucp2,Traf1,Cnn2,Arhgdib,Cd7,Selplg,Cytip,Itgb7,Fxyd5,Cd52,Klrk1,Klrd1,Tnfrsf1b,Il2rg,Coro1a,Hmha1,Rarres2,AB124611,Serpina3n","+0.0210,+0.0165,+0.0161,+0.0141,+0.0135,+0.0109,+0.0103,+0.0100,+0.0100,+0.0091,+0.0063,+0.0056,+0.0056,+0.0055,+0.0053,+0.0050,+0.0048,+0.0047,+0.0047,+0.0045","0.55,2.31,1.75,1.92,2.00,0.71,1.62,1.83,0.90,2.00,2.12,0.91,0.96,0.87,0.98,2.00,0.78,0.54,0.53,0.13"
+basal-IFE,6.543243408203125,17331,"Trp63,Itgb4,4631405K08Rik,Pdgfa,Fermt1,Cbr2,Tgfbi,Wnt16,Serpinb10,Mt2,Lhx2,Lgr6,Wnt10a,Antxr1,Ajuba,Lamc2,Irx2,Nnat,Dlk2,Ackr4","+0.0128,+0.0104,+0.0097,+0.0080,+0.0072,+0.0066,+0.0055,+0.0046,+0.0040,+0.0039,+0.0038,+0.0037,+0.0036,+0.0034,+0.0030,+0.0030,+0.0023,+0.0021,+0.0020,+0.0019","2.38,1.45,1.15,1.46,1.28,1.00,2.13,0.63,1.09,3.21,0.38,0.44,1.39,0.82,1.14,0.96,1.44,0.16,0.71,0.80"
+basal-multipotent,5.2563371658325195,8816,"Slco3a1,Lsr,Rab25,Gata3,Dapl1,Casz1,Ppl,Pycard,Chl1,Ptprf,Kif21a,Pdzk1ip1,Pou3f1,Il34,Tmprss4,Cidea,Pkib,Paqr5,Acsbg1,Mall","+0.0047,+0.0031,+0.0028,+0.0021,+0.0021,+0.0019,+0.0018,+0.0016,+0.0014,+0.0013,+0.0013,+0.0011,+0.0011,+0.0007,+0.0007,+0.0006,+0.0005,+0.0004,+0.0003,+0.0002","0.30,0.32,0.73,0.41,0.90,0.27,0.22,0.66,0.12,0.60,0.16,0.14,0.36,0.04,0.02,0.03,0.04,0.01,0.05,0.13"
+dermal-condensate,6.336891174316406,133,"Chchd10,Selenop,Gpx3,Pnpla2,Il1r2,Lpl,Rrbp1,Cmbl,Slc36a2,Sepp1,Selm,Gpd1,Gas6,Cidea,Aurkb,Ctsh,Cpa3,Lmnb1,Prc1,Cenpf","+0.0081,+0.0049,+0.0048,+0.0044,+0.0033,+0.0032,+0.0022,+0.0021,+0.0017,+0.0017,+0.0012,+0.0012,+0.0009,+0.0009,+0.0006,+0.0004,+0.0003,+0.0002,+0.0001,+0.0001","0.91,0.57,0.36,0.17,0.41,0.19,1.12,0.06,0.02,0.12,0.24,0.02,0.26,0.03,0.06,0.15,0.02,0.05,0.02,0.03"
+eccrine-duct,6.402817726135254,412,"Igf2,Crabp1,Mest,Dlk1,Nrp1,Agtr2,Hist1h2ap,Maged2,Ccne1,Cldn23,Elovl6,Vcam1,Spry2,Myh10,Twist2,Mdk,Efna5,Adcy1,Sox11,Nudt4","+0.0011,+0.0009,+0.0007,+0.0006,+0.0006,+0.0005,+0.0005,+0.0005,+0.0005,+0.0004,+0.0004,+0.0003,+0.0003,+0.0003,+0.0003,+0.0003,+0.0003,+0.0003,+0.0002,+0.0002","2.96,2.29,2.53,2.63,1.07,1.01,2.09,2.00,0.95,0.87,1.30,1.09,1.51,1.46,1.37,3.02,1.48,0.21,2.08,1.73"
+eccrine-ductal,4.872537612915039,653,"Zbtb20,Lgmn,Ctsh,Tmem106a,Crip1,Ctsz,Mylpf,Il4i1,Entpd2,Arpc1b,Timp2,Hexa,Cd302,Tnnc2,Hspb7,Bst2,Serping1,Cd34,Tcap,Ctsk","+0.0004,+0.0004,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","0.49,0.40,0.16,0.02,0.19,0.19,0.05,0.01,0.02,0.11,0.09,0.14,0.12,0.02,0.04,0.02,0.03,0.02,0.00,0.01"
+eccrine-placode,2.014130115509033,5,"Ndrg2,Lrrn1,Pnpla2,Chchd10,Il1r2,Gpx3,Timp2,Car3,mt-Atp6,Adig,Ctsh,Acta1,Cidec,Adipoq,Cidea,Cox8b,Hbb-bs,Il11ra1,Retn,Ppp1r1a","+0.0197,+0.0191,+0.0087,+0.0076,+0.0067,+0.0058,+0.0014,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","0.30,0.25,0.15,0.52,0.38,0.30,0.34,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00"
+eccrine-secretory,6.660486698150635,1025,"Pnpla2,Ppp1r1a,Chchd10,Pkib,Ndrg2,Cat,Lrrn1,Gas6,Gpx3,Gata3,Lpl,Gpd1,Ctsh,Agt,Fitm1,Il1r2,Adipoq,Cidea,Cma1,Cdh15","+0.0029,+0.0023,+0.0023,+0.0017,+0.0012,+0.0012,+0.0003,+0.0003,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","0.45,0.28,1.36,0.28,0.68,0.35,0.04,0.20,0.10,0.08,0.02,0.01,0.15,0.00,0.00,0.10,0.00,0.00,0.00,0.00"
+eden-dermal-niche,6.1107563972473145,3793,"Serping1,Fxyd1,Rarres2,Aebp1,Dpt,Ecm2,Olfml3,Fcgrt,Pcolce,Srpx,Adam33,Pcolce2,Cyp26b1,Eln,Cd34,Clec11a,Scara5,Cadm3,Htra3,Clec3b","+0.0073,+0.0068,+0.0056,+0.0048,+0.0047,+0.0046,+0.0040,+0.0038,+0.0037,+0.0037,+0.0027,+0.0023,+0.0022,+0.0019,+0.0017,+0.0017,+0.0015,+0.0015,+0.0013,+0.0012","1.38,1.17,0.99,1.11,0.83,0.43,0.53,0.87,0.85,0.42,0.23,0.41,0.23,0.29,0.22,0.31,0.26,0.17,0.14,0.19"
+endothelial,5.234022617340088,2339,"Ecscr,Tmem88,Grrp1,Fam167b,C1qtnf9,Emcn,Egfl7,Rasip1,Cd300lg,Esam,Gpihbp1,Aplnr,Cdh5,Mmrn2,Robo4,Adgrf5,Myct1,Meox1,Apold1,Icam2","+0.0075,+0.0050,+0.0049,+0.0048,+0.0043,+0.0043,+0.0041,+0.0041,+0.0039,+0.0039,+0.0037,+0.0036,+0.0032,+0.0031,+0.0027,+0.0027,+0.0026,+0.0022,+0.0019,+0.0019","2.33,1.09,1.05,0.67,0.90,2.04,2.53,1.59,0.72,1.97,1.40,1.12,2.22,1.24,1.05,1.41,1.67,0.96,1.29,1.65"
+fibroblast,6.262070178985596,1242,"Gpx3,Chchd10,Pnpla2,Fxyd1,Hmgb2,Agt,Kif22,Ppp1r1a,Ccnb1,Lmnb1,Ccnb2,Ckap2,Cenpf,Cpa3,Ccna2,Lpl,Cma1,Cdca3,Tacc3,Cenpe","+0.0004,+0.0004,+0.0001,+0.0001,+0.0001,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","0.43,0.59,0.24,1.03,0.74,0.03,0.17,0.02,0.02,0.01,0.01,0.04,0.01,0.00,0.02,0.12,0.00,0.01,0.01,0.01"
+fibroblast-papillary,6.645598411560059,1485,"Zbtb20,Cyp4b1,Agtr1a,Cyp26b1,Mt2,Steap4,Ccl11,Avpr1a,Ecm1,Fxyd1,Mitf,Cd200,Pparg,Scd1,Ank,Cyr61,Hbb-bt,Hba-a2,Gas7,Actc1","+0.0010,+0.0008,+0.0006,+0.0004,+0.0003,+0.0003,+0.0003,+0.0002,+0.0002,+0.0002,+0.0002,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0000,+0.0000","1.48,0.93,0.41,0.26,0.44,0.86,0.84,0.34,0.63,1.64,0.09,0.52,0.07,0.08,0.07,0.93,0.13,0.32,0.05,0.02"
+fibroblast-reticular,15.847702980041504,33846,"Crabp1,Wnt5a,Tmem132c,Nkd1,Myh10,Tril,Clmp,Sox11,Dpysl3,Prrx2,Scarf2,Rhoc,Nnat,Vcan,Tmem119,Rhoj,Pdgfra,Gap43,Igf2,Nrp1","+0.0018,+0.0017,+0.0016,+0.0012,+0.0012,+0.0010,+0.0010,+0.0010,+0.0009,+0.0008,+0.0007,+0.0007,+0.0007,+0.0004,+0.0004,+0.0004,+0.0004,+0.0004,+0.0003,+0.0003","1.11,0.68,0.99,0.81,0.85,0.63,1.54,0.51,1.09,1.30,0.99,1.90,0.48,1.33,0.97,1.34,1.12,0.64,0.87,1.03"
+granular,5.623369216918945,240,"Alox12e,Skint9,Fcgbp,Urah,Tnfrsf18,Sepp1,Ckmt1,Slco2a1,Bcam,Zbtb20,Wnt10a,Agpat4,Lbp,Olfml3,Clca3a2,Cpq,Ifi205,Tnmd,Pi16,Gm13305","+0.0069,+0.0024,+0.0006,+0.0005,+0.0005,+0.0004,+0.0004,+0.0002,+0.0001,+0.0001,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","1.14,1.10,0.30,0.72,0.24,0.74,0.54,0.13,0.21,0.16,0.05,1.29,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00"
+hair-placode,6.327608108520508,101,"Pnpla2,Chchd10,Cidea,Il1r2,Ppp1r1a,Gpd1,Gpx3,Rrbp1,Pcolce2,Gas6,Fitm1,Plpp3,Clec11a,Aebp1,Lpl,Fkbp7,Mylpf,Cd302,Pi16,Irx1","+0.0164,+0.0101,+0.0042,+0.0028,+0.0028,+0.0020,+0.0016,+0.0015,+0.0010,+0.0008,+0.0007,+0.0006,+0.0006,+0.0003,+0.0003,+0.0002,+0.0001,+0.0001,+0.0000,+0.0000","0.43,0.83,0.09,0.30,0.06,0.02,0.10,0.74,0.04,0.15,0.01,0.11,0.06,0.05,0.01,0.05,0.02,0.01,0.01,0.13"
+immune,6.741326808929443,10847,"Lpl,Gpx3,Fcgrt,Mfge8,Meg3,Eln,Fstl1,Osr2,Sparc,Adam33,Ebf1,Fbln5,C1qtnf6,Cyp2f2,Skint10,Gm94,Pla2g2f,Skint6,Tspan4,Fxyd1","+0.0013,+0.0005,+0.0002,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,-0.0000,-0.0000,-0.0000","0.34,0.32,0.41,0.30,0.30,0.24,0.38,0.06,2.09,0.03,0.08,0.07,0.13,0.02,0.00,0.02,0.01,0.00,0.18,0.10"
+melanocyte,5.752284049987793,488,"Mcoln3,Syngr1,Tyr,Slc45a2,Trpm1,Gsta1,Syt4,Tspan10,Alx1,Cpne4,Gpr143,Car14,Kit,Mlana,Car8,Glrb,Synpr,Qpct,C2,Mc1r","+0.0038,+0.0033,+0.0030,+0.0030,+0.0022,+0.0019,+0.0017,+0.0015,+0.0015,+0.0014,+0.0013,+0.0013,+0.0012,+0.0011,+0.0009,+0.0008,+0.0008,+0.0007,+0.0007,+0.0007","1.93,2.18,1.71,1.20,2.03,1.03,0.99,0.70,0.72,0.63,0.90,0.55,2.02,3.34,0.28,1.03,0.68,2.10,0.77,0.69"
+nascent-eccrine-gland,2.2634172439575195,17,"Pdlim3,Pnpla2,Chchd10,Hspb7,Cidea,Lpl,Il1r2,P4ha2,Cyba,Prdx4,Timp2,Aebp1,Ctsh,Gas6,Ctsz,Acta1,Tnnc2,Lgals9,Ifi204,Pgam2","+0.0384,+0.0273,+0.0260,+0.0246,+0.0239,+0.0145,+0.0119,+0.0057,+0.0054,+0.0016,+0.0012,+0.0010,+0.0010,+0.0006,+0.0003,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","0.33,0.23,0.95,0.14,0.31,0.29,0.34,0.22,0.57,0.25,0.15,0.08,0.10,0.10,0.29,0.00,0.00,0.00,0.00,0.00"
+sebaceous,7.088693618774414,852,"Cidec,Adipoq,Lpl,Cidea,Adig,Cma1,Cox8b,Hbb-bs,Retn,Car3,Gpd1,Tpsb2,Gpx3,Pnpla2,Smoc1,Hba-a1,Chchd10,Ltc4s,Hba-a2,Hp","+0.0032,+0.0031,+0.0023,+0.0017,+0.0014,+0.0013,+0.0012,+0.0011,+0.0011,+0.0010,+0.0008,+0.0008,+0.0008,+0.0007,+0.0006,+0.0005,+0.0004,+0.0004,+0.0003,+0.0002","2.85,3.34,3.83,2.37,1.82,1.04,1.99,2.84,1.47,2.54,1.59,0.64,3.59,3.50,0.26,1.77,4.17,0.23,1.43,1.29"
+spinous,6.351413249969482,12085,"Paqr5,Gm94,Lsr,Gm16136,Gjb5,Ly6g6e,Skint11,Gdpd2,Reep4,Avpi1,Il1f5,Klc3,Crlf1,Tmprss4,Cfap57,Rab25,Clec3b,Selm,Ctsz,Rcn3","+0.0226,+0.0136,+0.0125,+0.0124,+0.0112,+0.0107,+0.0083,+0.0068,+0.0066,+0.0063,+0.0048,+0.0028,+0.0027,+0.0019,+0.0014,+0.0011,+0.0007,+0.0006,+0.0006,+0.0005","0.75,0.91,1.04,0.71,0.93,0.79,0.43,0.47,0.97,1.44,0.23,1.68,0.31,1.01,0.56,2.37,0.10,0.13,0.08,0.09"
+unassigned,7.1785969734191895,647,"Alcam,Irx2,Nbl1,Hspb7,Tgfbi,Tbx1,Tgm5,Hspb6,Lgmn,Sh3bgr,Ctsh,Eno3,Ank1,Rnase4,Tmem106a,Atp6v1b1,Lgals9,Trdn,Sostdc1,Klhl41","+0.0070,+0.0057,+0.0024,+0.0022,+0.0019,+0.0014,+0.0011,+0.0009,+0.0008,+0.0006,+0.0005,+0.0005,+0.0004,+0.0004,+0.0004,+0.0003,+0.0003,+0.0003,+0.0002,+0.0002","0.34,0.35,0.36,0.09,0.26,0.03,0.02,0.05,0.26,0.02,0.18,0.02,0.02,0.37,0.04,0.00,0.02,0.01,0.00,0.01"

discovery/81_pancreas_ko_essentials.csv

@@ -0,0 +1,17 @@
+class,baseline_cos,n_cells_class,top_essential_genes,top_essential_deltas,top_essential_baseline_expression
+UNK,5.575767517089844,13010,"Zeb2,Lhfp,Ube2i,Tcf21,Zfos1,Tgfbi,Hoxb2,Emp3,Pgam1,Cnn2,Stmn1,Lgals1,Hic1,Rbpjl,Bex4,Wfdc15b,Cpa1,Cpa2,Tshz2,Cldn10","+0.0008,+0.0005,+0.0004,+0.0003,+0.0002,+0.0002,+0.0002,+0.0002,+0.0002,+0.0001,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,-0.0000,-0.0000,-0.0000","1.18,1.02,1.11,1.18,0.80,0.73,0.86,1.96,0.94,1.48,1.18,3.42,0.72,0.07,0.88,0.20,0.95,0.68,2.12,0.25"
+acinar,5.872268199920654,6091,"Tinag,Serpinb1a,Serpini1,Ptf1a,Serpinf2,Igf1,Nup62cl,Rbp1,Vim,Ggh,Sparc,Sostdc1,Sepp1,Ddah2,Bok,Gamt,Mdfi,1700011H14Rik,Hhex,Col9a1","+0.0065,+0.0056,+0.0051,+0.0042,+0.0038,+0.0034,+0.0032,+0.0028,+0.0024,+0.0016,+0.0014,+0.0014,+0.0012,+0.0009,+0.0006,+0.0006,+0.0006,+0.0005,+0.0004,+0.0001","1.74,2.20,1.71,2.70,1.22,2.43,0.93,0.99,0.90,2.90,0.90,0.49,3.07,0.47,1.42,3.25,0.44,0.36,0.53,0.07"
+adult-alpha,5.793132305145264,1904,"Ugt2b34,Egr1,Rab27b,Pdzk1ip1,Pamr1,Smim6,Lurap1l,Ggh,Edem2,Clu,Akr1c19,Anpep,Cxadr,Capg,Gm15915,Tmed6,Tle6,Muc1,Bicc1,Krt19","+0.0060,+0.0048,+0.0023,+0.0021,+0.0019,+0.0019,+0.0018,+0.0016,+0.0012,+0.0012,+0.0011,+0.0007,+0.0005,+0.0005,+0.0004,+0.0003,+0.0003,+0.0002,+0.0002,+0.0002","0.70,0.30,0.16,0.43,0.30,0.07,0.37,0.35,0.37,0.83,0.30,0.04,0.14,0.08,0.05,0.03,0.08,0.02,0.10,0.03"
+adult-beta,4.5231170654296875,14999,"Lurap1l,Anpep,Smim6,Rap1gap,Dcdc2a,Bicc1,Smc4,Lockd,Ghrl,Rab27b,Ctrb1,Kctd14,Prc1,Muc1,Tinagl1,Top2a,Try5,Cks2,Kif23,Cela3b","+0.0014,+0.0010,+0.0006,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","0.51,0.09,0.03,0.09,0.12,0.08,0.06,0.02,0.00,0.01,0.02,0.00,0.01,0.01,0.01,0.01,0.00,0.01,0.00,0.00"
+alpha,6.947467803955078,2834,"Irx1,Irx2,Slc14a2,Dusp10,Tmem27,Sct,Arx,Slc38a5,Gast,Pim2,Cbfa2t3,Nptx2,Mapk15,Gatsl2,Tff3,Cd164l2,Igsf21,Baiap3,Igfbpl1,Neurog3","+0.0050,+0.0043,+0.0030,+0.0022,+0.0021,+0.0021,+0.0014,+0.0012,+0.0011,+0.0007,+0.0006,+0.0005,+0.0005,+0.0005,+0.0004,+0.0004,+0.0004,+0.0003,+0.0003,+0.0003","1.41,1.48,0.66,1.66,2.19,1.50,2.12,2.51,1.17,1.84,0.89,0.25,1.33,1.83,0.54,1.37,0.50,1.19,1.42,0.72"
+beta,6.519139289855957,15569,"Snca,Alas2,Slc4a1,Car2,Trim10,Nusap1,Ube2c,Fev,Cdk1,Cyr61,Asf1b,Fbxo5,Smc4,Rrm2,Mis18bp1,Dut,Prc1,Top2a,Csrp2,Psat1","+0.0495,+0.0465,+0.0376,+0.0347,+0.0339,+0.0098,+0.0090,+0.0072,+0.0071,+0.0071,+0.0065,+0.0059,+0.0058,+0.0057,+0.0054,+0.0053,+0.0050,+0.0044,+0.0043,+0.0040","0.66,0.71,0.17,0.38,0.11,0.54,1.43,0.79,0.89,1.01,0.44,0.56,1.13,0.93,0.36,1.92,0.42,0.78,1.78,0.70"
+delta,9.329307556152344,13914,"Hmga1,Cpn1,Dctpp1,Bmp7,Bex4,Bex1,Dut,Vtn,Pla2g12a,Homer2,Ptf1a,Serpina6,P2rx1,Smco4,Gstp1,Tmem97,Gcat,Cckar,Phgdh,Nr5a2","+0.0150,+0.0099,+0.0098,+0.0091,+0.0071,+0.0068,+0.0060,+0.0059,+0.0059,+0.0059,+0.0057,+0.0055,+0.0052,+0.0050,+0.0045,+0.0041,+0.0036,+0.0035,+0.0033,+0.0032","1.22,1.47,2.78,1.56,3.06,3.11,2.52,1.53,2.29,1.78,0.91,2.30,1.20,2.78,1.70,1.93,1.89,0.97,2.99,1.27"
+ductal,6.1037983894348145,7565,"Selm,Grin3a,Cited1,Bambi,Fam89a,Higd1a,Spon1,Arpc1b,Lox,Pcna,Tcf19,Tmem27,Cd34,Colec12,Tmsb15l,Hells,Ccne2,Ccne1,Cotl1,Dhfr","+0.0005,+0.0003,+0.0003,+0.0003,+0.0003,+0.0003,+0.0002,+0.0002,+0.0002,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001,+0.0001","1.87,0.10,1.24,1.32,0.48,2.26,0.55,2.49,0.45,1.00,0.47,0.17,0.52,0.49,0.13,1.08,0.38,0.41,1.12,0.94"
+endocrine-progenitor,6.250603675842285,5862,"Anpep,Ier2,Ass1,Smco4,Serpina6,Sdsl,Gcat,Fabp5,Tmem97,Gamt,Dbi,Arhgdig,Gm15915,Phgdh,Hpn,Hacd1,Acot1,Cckar,Tmed6,Tyms","+0.0291,+0.0198,+0.0187,+0.0152,+0.0147,+0.0145,+0.0137,+0.0130,+0.0125,+0.0115,+0.0109,+0.0105,+0.0102,+0.0099,+0.0089,+0.0088,+0.0077,+0.0075,+0.0070,+0.0067","0.93,2.88,0.96,2.26,2.42,1.25,1.95,2.56,2.05,1.97,2.76,0.89,0.72,2.34,1.14,2.03,1.92,1.19,1.18,1.82"
+endothelial,6.707540988922119,983,"Epas1,Cd93,Mcam,Thbs1,Ets1,Anxa3,S1pr1,Tmem204,Adgrl4,Bhlhe40,Apold1,Ptprb,Msn,Tm4sf1,Fxyd5,Edn1,Serinc3,Procr,Erg,Il2rg","+0.0020,+0.0018,+0.0017,+0.0017,+0.0017,+0.0016,+0.0016,+0.0016,+0.0015,+0.0013,+0.0013,+0.0012,+0.0012,+0.0011,+0.0011,+0.0010,+0.0009,+0.0007,+0.0006,+0.0006","1.22,2.09,0.86,0.82,1.76,2.18,1.37,1.38,1.11,0.54,1.24,1.22,2.80,2.52,1.61,0.91,1.64,1.41,1.05,0.54"
+epsilon,0.6536498069763184,1,"Gpa33,Amigo2,Tubb4b,Serpina1e,Pabpn1l,Arx,Gm2694,Mnx1,Mfap4,Cbx3,Tcf21,Fam159b,Ube2i,Gip,Mapt,Adra2a,Vimp,Cdca3,Zfos1,Lrp8","+0.0293,+0.0055,+0.0021,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","1.47,1.47,1.47,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00"
+gamma,9.540014266967773,10271,"Pid1,Slit2,Fstl1,Bgn,Zeb2,Myl9,Cald1,Mest,Glipr2,Hoxb4,Cck,Smoc2,Snai2,Vwa5b2,Cnn2,Pcbd1,Axl,Nid1,Prkcdbp,Akr1c19","+0.0154,+0.0129,+0.0121,+0.0114,+0.0112,+0.0110,+0.0109,+0.0096,+0.0096,+0.0086,+0.0086,+0.0084,+0.0081,+0.0075,+0.0065,+0.0064,+0.0062,+0.0049,+0.0046,+0.0043","0.55,0.83,1.69,0.70,0.72,1.07,2.51,2.73,1.08,1.27,0.29,1.51,0.58,0.31,1.19,0.78,0.48,0.44,1.56,0.13"
+immune,6.9257612228393555,2279,"Fyb,Pou2f2,Unc93b1,Tifab,Ly86,P2ry6,Csf1r,Stab1,AF251705,Fcrls,Lrrc25,Cx3cr1,Aif1,Tnfaip8l2,Lst1,AB124611,Cd300a,Mpeg1,Cd68,Hck","+0.0018,+0.0015,+0.0013,+0.0013,+0.0013,+0.0013,+0.0013,+0.0013,+0.0012,+0.0012,+0.0012,+0.0011,+0.0010,+0.0010,+0.0010,+0.0010,+0.0010,+0.0010,+0.0009,+0.0009","2.27,1.21,2.71,1.11,1.99,1.92,2.68,1.83,1.07,1.87,1.33,2.30,2.73,2.00,2.70,1.43,1.51,1.55,2.67,1.23"
+mesenchymal,3.9302384853363037,13,"Clec3b,Cd44,Col3a1,Col1a1,Sparcl1,Hmga1,Myc,Lpar1,Gm10073,Tgfbi,Ybx3,Ube2s,Fam129a,Sfn,Sox9,Hoxa5,Pgam1,5033428I22Rik,Gas1,Osr1","+0.0621,+0.0468,+0.0236,+0.0220,+0.0130,+0.0100,+0.0095,+0.0040,+0.0038,+0.0037,+0.0031,+0.0031,+0.0030,+0.0030,+0.0025,+0.0022,+0.0020,+0.0020,+0.0016,+0.0015","2.80,1.74,3.48,2.78,3.12,0.65,1.71,0.97,0.91,0.35,0.43,2.05,0.14,0.14,0.90,0.11,1.03,0.25,0.48,0.11"
+other,6.8541154861450195,8470,"Akr1c19,Cldn6,Grb7,Mgll,Ambp,Cmtm8,Sox9,Smco4,Gstp1,1700011H14Rik,Espn,Gsta3,Cldn3,Wfdc2,Gc,Smtnl2,Bmp7,Rab25,Habp2,Acot1","+0.0052,+0.0048,+0.0044,+0.0040,+0.0040,+0.0038,+0.0038,+0.0035,+0.0034,+0.0032,+0.0031,+0.0029,+0.0029,+0.0028,+0.0028,+0.0027,+0.0027,+0.0027,+0.0025,+0.0025","1.93,2.76,1.40,1.83,3.19,2.09,1.66,2.88,2.38,1.08,1.94,1.61,2.76,2.42,2.81,1.16,1.99,2.29,1.43,2.10"
+unassigned,5.682777404785156,20816,"Tinagl1,Mest,Col9a3,Dcdc2a,Gpx2,Ppp1r1b,Grin3a,Igfbp4,Pdzk1ip1,Prss1,Chst2,Car14,Ung,Neurog3,Bicc1,Try10,Lurap1l,Vtn,Muc1,Kctd14","+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000,+0.0000","0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00"

discovery/82_hematopoiesis_coatt_modules.csv

@@ -0,0 +1,8 @@
+module_id,size,dominant_class,dom_class_mean_att,member_genes,n_shown
+4,3,MPP,0.05044599995017052,"Cd83,Cpe,4933437F05Rik",3
+10,3,T-cell,0.5111035704612732,"Ccl21b.1,AI848285,Gsn",3
+14,3,erythroid,0.5434226393699646,"Lum,Ibsp,Car2",3
+5,3,erythroid,0.3027745187282562,"Ugt8a,D16H22S680E,Eln",3
+1,62,erythroid,8.801214789855294e-06,"Camp,Ms4a1,Ccr7,Acod1,Mia,Myoc,Bglap,Bglap3,Cd200r3,Gata2,Mal,Cd3g,Lypd2,Enpp2,Bglap2,Hapln2,Slpi,Epor,Ucma,Ccl3,Ifitm5,Slamf1,Ms4a4b,Cd74,Cxcr6,Hapln1,Tmem149,Cma1,Cd7,Pi16",30
+3,5,fibroblast,0.13048098981380463,"Postn,Adm,H2-M2,Ceacam15,Ifit1",5
+7,203,lymphoid,0.053714461624622345,"Igj,Klra9,Mpl,Pglyrp1,Cxcl2,Akr1c18,Cebpa,Dntt,Wfdc21,Meis1,Hba-a1,Lect1,Ins1,Sostdc1,Gp1ba,Cilp,Gjb1,Fez1,2010001M09Rik,Trf,Angptl7,Hbb-b1,Car1,Fn1,Spp1,Hdc,Siglech,Hbb-bt,Cd177,Mog",30

discovery/82_pan_skin_coatt_modules.csv

@@ -0,0 +1,14 @@
+module_id,size,dominant_class,dom_class_mean_att,member_genes,n_shown
+11,3,HF-placode,0.11391708999872208,"Cyp2f2,Fxyd1,Dpep1",3
+13,93,UNK,0.4454268217086792,"H2-D1,Cd86,H2-K1,Psmb8,Spi1,Ctss,H2-Aa,Laptm5,H2-Eb1,Fcer1g,H2-Ab1,Alox5ap,Cd68,Lilrb4a,Tyrobp,Ms4a6c,Napsa,Ucp2,H2-DMa,Csf1r,H2-DMb1,Slfn2,Coro1a,Adgre1,Cd53,Cd72,Ms4a6d,Cfp,Ifi30,Cd52",30
+7,36,UNK,0.19294297695159912,"Ifi205,AI607873,Sepp1,Lgals9,Hexa,2700094K13Rik,Ctsz,Cyba,Bst2,Ly6e,Nfib,Arhgdib,Ifi204,Arpc1b,Stab1,Nrm,Cdca3,Dap,Lockd,Ube2s,Ptn,Ifi27l2a,Lgals3bp,Lgmn,Hmgb2,Ccnb2,Crip1,Tmem106a,Smc4,Tpx2",30
+14,8,basal-IFE,0.3554476499557495,"Gm94,Skint10,Skint9,Hal,Skint6,Psapl1,2310050C09Rik,Skint5",8
+3,41,fibroblast-reticular,0.5302213430404663,"Nnat,Nrp1,Sox11,Lix1,Crabp1,Tubb2b,Cdkn1c,Mest,Dlk1,Vcam1,Fibin,H19,Osr1,Zfhx4,Basp1,6330403K07Rik,Igf2,Hbb-bt,Limd2,Hmga2,Agtr2,Maged2,Flrt2,Hic1,Gap43,Nrk,Nrgn,Emilin1,Wnt5a,Spock3",30
+9,33,fibroblast-reticular,0.4981513023376465,"Dab2,Irx1,Prdx4,Lpar1,Efemp2,Gas1,Ostc,Gpx7,Fkbp10,Rrbp1,P3h3,Rcn1,Twist2,Pdgfra,Sulf2,Rhoj,Rspo1,Gxylt2,Plod1,Prrx1,Pth1r,Kdelr2,Ckap4,Cmtm3,Prrx2,Ndn,Islr,Tmem132c,Scarf2,Figf",30
+10,8,fibroblast-reticular,0.4498068690299988,"Osr2,Adam33,Penk,Meg3,Itih5,Egfl6,Gpc3,Fstl1",8
+8,142,fibroblast-reticular,0.2082962840795517,"Serpina3n,Gas6,Cd34,Clec3b,Htra3,Ccl11,Selm,Pcolce2,Htra1,Rarres2,Rnase4,Adamts2,Il11ra1,Cpz,Prkcdbp,Cd302,Aebp1,Scara5,Ly6c1,Serping1,Fkbp7,P4ha2,Nbl1,Aldh3a1,Srpx,Mmp23,Creb3l1,Col5a1,Rcn3,Copz2",30
+2,61,nascent-eccrine-gland,0.4227891266345978,"Cox8b,Car3,Adipoq,Cidec,Cidea,Hbb-bs,Chchd10,Pnpla2,Hba-a1,Acta1,Lpl,Myl1,Adig,Cma1,Hba-a2,Gpx3,Gpd1,Cdo1,Ppp1r1a,Actc1,Retn,8430408G22Rik,Tpsb2,Tnnc2,Pgam2,Ckm,Fitm1,Agt,Des,Mylpf",30
+1,3,nascent-eccrine-gland,0.20813654363155365,"Adh1,Atp1a2,Smoc1",3
+15,7,sebaceous,0.37050822377204895,"Alox12e,Defb6,Krt79,Pkib,Fam25c,Skint3,Susd2",7
+6,60,sebaceous,0.1591878980398178,"Ctsh,Tgfbi,mt-Atp6,Trp63,Lmo1,Sostdc1,Il1r2,Lhx2,Bcam,Ckmt1,Capg,Ackr4,Urah,4631405K08Rik,Tnfrsf18,Cbr2,Sult5a1,Fermt1,Gm13305,Mt2,Itgb4,Anxa8,Fcgbp,Plek2,Wnt10a,Moxd1,Capns2,Dlk2,Gm16136,Cdh13",30
+5,3,unassigned,0.08320233225822449,"Ass1,Wnt6,Bmp7",3

discovery/82_pancreas_coatt_modules.csv

@@ -0,0 +1,12 @@
+module_id,size,dominant_class,dom_class_mean_att,member_genes,n_shown
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+6,6,beta,0.1530652940273285,"Gpx2,Grin3a,Neurog3,2010107G23Rik,St3gal6,Mmd2",6
+9,3,immune,0.2384834885597229,"Cmtm7,Arpc1b,Cyba",3
+11,115,mesenchymal,0.20030100643634796,"Cldn10,Rbpjl,Phgdh,Ube2s,Aldh1b1,Cpa2,Cdca3,Tmem97,Cpa1,Gamt,Wfdc15b,Ube2i,Cckar,Spc24,Cks2,Gcat,Bex4,Serpina6,Tmem238,Smco4,Akr1c19,Slc38a3,Wfdc2,Cmtm8,Rab25,Ptf1a,Pgam1,Cldn6,Ccna2,Ambp",30
+12,10,mesenchymal,0.1333482563495636,"Tuba4a,Ffar2,Fxyd3,Anxa4,Foxa3,Rab3d,Npepl1,Nkx6-1,Foxa2,Nkx2-2",10
+8,151,mesenchymal,0.12115053832530975,"Muc1,Tinagl1,Adamts9,Mgst1,Gsta3,Bst2,Bicc1,Nudt19,Cldn3,1700011H14Rik,Prss8,Smtnl2,Ugt2b34,Mia,Dcdc2a,Tle6,Tst,Clu,Dbi,Habp2,Col9a3,Psat1,Krt19,Ttyh1,Ppp1r1b,Sdsl,Lurap1l,Mki67,Pdlim1,Aurkb",30
+5,59,other,0.5559389591217041,"Tcf21,Sparcl1,6330403K07Rik,Col1a1,Mfap2,Mfap4,Sfrp1,Col3a1,Gap43,Col1a2,Islr,F2r,Nkain4,Fstl1,Cmtm3,Basp1,Rcn3,Gas1,Hic1,Des,Emilin1,Ldb2,Lhfp,Nefl,Tgfbi,Bgn,Lpar1,Slit2,Col6a1,Ppic",30
+2,8,other,0.5294446349143982,"Alas2,Hbb-y,Car2,Hba-x,Slc4a1,Snca,Trim10,Hbb-bt",8
+4,3,other,0.445279985666275,"Cnn2,Ramp2,Rgcc",3
+3,4,unassigned,0.6882850527763367,"Mest,Igfbp4,Fscn1,Tuba1a",4
+10,72,unassigned,0.23275692760944366,"P2rx1,Hist1h2ap,Gc,Gmnn,Chst2,Cpn1,Tmem54,Homer2,Dut,Bmp7,Vtn,Hmga1,Dctpp1,Lig1,Tyms,Noxa1,Ung,Cbx3,Rrm2,2810417H13Rik,Uhrf1,Lyar,Tipin,Tk1,Bok,Rhov,Slbp,Mcm5,Dhfr,Matn4",30

discovery/84_adversary_purification.json

@@ -0,0 +1,38 @@
+{
+  "pan_skin": {
+    "system": "pan_skin",
+    "n_cells": 20000,
+    "n_train_datasets": 9,
+    "dataset_adv_accuracy": 0.71355,
+    "dataset_adv_chance": 0.1111111111111111,
+    "dataset_adv_above_chance": 0.602438888888889,
+    "dataset_adv_random_baseline_test": "n_datasets=9, chance=0.111",
+    "depth_adv_mse_z": 0.484615530480883,
+    "depth_adv_r2_z": 0.5153844424019848,
+    "depth_target_std_z": 0.999999972022016
+  },
+  "hematopoiesis": {
+    "system": "hematopoiesis",
+    "n_cells": 20000,
+    "n_train_datasets": 2,
+    "dataset_adv_accuracy": 0.9611,
+    "dataset_adv_chance": 0.5,
+    "dataset_adv_above_chance": 0.46109999999999995,
+    "dataset_adv_random_baseline_test": "n_datasets=2, chance=0.500",
+    "depth_adv_mse_z": 0.9977265049050998,
+    "depth_adv_r2_z": 0.0022733099069626173,
+    "depth_target_std_z": 0.9999999071950526
+  },
+  "pancreas": {
+    "system": "pancreas",
+    "n_cells": 20000,
+    "n_train_datasets": 5,
+    "dataset_adv_accuracy": 0.9826,
+    "dataset_adv_chance": 0.2,
+    "dataset_adv_above_chance": 0.7826,
+    "dataset_adv_random_baseline_test": "n_datasets=5, chance=0.200",
+    "depth_adv_mse_z": 0.3804574130413597,
+    "depth_adv_r2_z": 0.6195425628499744,
+    "depth_target_std_z": 0.9999999683162111
+  }
+}

discovery/85_hematopoiesis_hessian_pairs.csv

@@ -0,0 +1,241 @@
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+erythroid,Car2,Mmp8,-0.0007865505176596344,0.0007865505176596344,0.31859955191612244,-0.1523493081331253
+erythroid,Car2,Mpo,0.0007801767787896097,0.0007801767787896097,0.31859955191612244,0.08100587129592896
+erythroid,Pf4,Gp1bb,-0.0007717163534834981,0.0007717163534834981,-0.11342952400445938,-0.10475057363510132
+erythroid,Hba-a1,Cd48,0.0007710778154432774,0.0007710778154432774,0.2011345773935318,0.11565357446670532
+erythroid,Mmp8,Mpo,0.0007387777441181242,0.0007387777441181242,-0.1523493081331253,0.08100587129592896
+erythroid,Flt3,Cd48,-0.0007100988295860589,0.0007100988295860589,0.16927406191825867,0.11565357446670532
+erythroid,Pf4,Dntt,0.0006798943504691124,0.0006798943504691124,-0.11342952400445938,0.07114870101213455
+erythroid,Meis1,Mmp8,0.0006568909739144146,0.0006568909739144146,0.2451801896095276,-0.1523493081331253
+erythroid,Flt3,Mmp8,0.0006546881631948054,0.0006546881631948054,0.16927406191825867,-0.1523493081331253
+erythroid,Car1,Pf4,-0.0006159425829537213,0.0006159425829537213,0.29042068123817444,-0.11342952400445938
+erythroid,Wfdc17,Gp1bb,-0.0006101544131524861,0.0006101544131524861,-0.1453569531440735,-0.10475057363510132
+erythroid,Hba-a1,Wfdc17,-0.0006081606261432171,0.0006081606261432171,0.2011345773935318,-0.1453569531440735
+erythroid,Meis1,Pf4,0.0005791615694761276,0.0005791615694761276,0.2451801896095276,-0.11342952400445938
+erythroid,Hba-a1,Gp1bb,-0.0005572366644628346,0.0005572366644628346,0.2011345773935318,-0.10475057363510132
+erythroid,Klf1,Meis1,0.0005558856064453721,0.0005558856064453721,0.30630505084991455,0.2451801896095276
+erythroid,Flt3,Gp1bb,0.000552952813450247,0.000552952813450247,0.16927406191825867,-0.10475057363510132
+erythroid,Car2,Cd48,0.0005268377135507762,0.0005268377135507762,0.31859955191612244,0.11565357446670532
+lymphoid,Sell,Wfdc17,-0.05589454993605614,0.05589454993605614,-0.06405871361494064,-0.05408059433102608
+lymphoid,Cpa3,Itga2b,0.049310486763715744,0.049310486763715744,0.09760438650846481,-0.0675913468003273
+lymphoid,Dntt,Cd48,0.04859450086951256,0.04859450086951256,0.048468105494976044,-0.0480826161801815
+lymphoid,Mmp8,Sell,0.048024702817201614,0.048024702817201614,-0.08025801181793213,-0.06405871361494064
+lymphoid,Sell,Car2,0.04360489919781685,0.04360489919781685,-0.06405871361494064,-0.05609077960252762
+lymphoid,Cpa3,Car2,0.042353078722953796,0.042353078722953796,0.09760438650846481,-0.05609077960252762
+lymphoid,Cpa3,Wfdc17,-0.040838003158569336,0.040838003158569336,0.09760438650846481,-0.05408059433102608
+lymphoid,Mpo,Mmp8,0.03519504517316818,0.03519504517316818,-0.10126742720603943,-0.08025801181793213
+lymphoid,Csf1r,Flt3,-0.03463730961084366,0.03463730961084366,-0.08843646198511124,0.0363762304186821
+lymphoid,Mpo,Itga2b,-0.034296441823244095,0.034296441823244095,-0.10126742720603943,-0.0675913468003273
+lymphoid,Sell,Cd48,0.032559946179389954,0.032559946179389954,-0.06405871361494064,-0.0480826161801815
+lymphoid,Elane,Wfdc17,0.030562428757548332,0.030562428757548332,-0.10759017616510391,-0.05408059433102608
+lymphoid,Hlf,Car2,-0.03013261780142784,0.03013261780142784,-0.06686992198228836,-0.05609077960252762
+lymphoid,Slamf1,Car2,-0.029710471630096436,0.029710471630096436,-0.23383143544197083,-0.05609077960252762
+lymphoid,Car2,Cd48,-0.02967050112783909,0.02967050112783909,-0.05609077960252762,-0.0480826161801815
+lymphoid,Mllt3,Car2,-0.02955946885049343,0.02955946885049343,-0.12498603761196136,-0.05609077960252762
+lymphoid,Mpo,Car2,-0.029503406956791878,0.029503406956791878,-0.10126742720603943,-0.05609077960252762
+lymphoid,Elane,Flt3,-0.028051216155290604,0.028051216155290604,-0.10759017616510391,0.0363762304186821
+lymphoid,Mpo,Hlf,-0.02795853652060032,0.02795853652060032,-0.10126742720603943,-0.06686992198228836
+lymphoid,Elane,Pf4,0.0276082381606102,0.0276082381606102,-0.10759017616510391,-0.05713808164000511
+lymphoid,Meis1,Wfdc17,-0.027516160160303116,0.027516160160303116,-0.11696286499500275,-0.05408059433102608
+lymphoid,Slamf1,Csf1r,-0.026966581121087074,0.026966581121087074,-0.23383143544197083,-0.08843646198511124
+lymphoid,Csf1r,Cd48,-0.026444144546985626,0.026444144546985626,-0.08843646198511124,-0.0480826161801815
+lymphoid,Slamf1,Hlf,-0.026353197172284126,0.026353197172284126,-0.23383143544197083,-0.06686992198228836
+lymphoid,Sell,Pf4,-0.025813400745391846,0.025813400745391846,-0.06405871361494064,-0.05713808164000511
+lymphoid,Mpo,Cd48,-0.02555365115404129,0.02555365115404129,-0.10126742720603943,-0.0480826161801815
+lymphoid,Slamf1,Cd48,-0.025353511795401573,0.025353511795401573,-0.23383143544197083,-0.0480826161801815
+lymphoid,Itga2b,Car2,-0.024459676817059517,0.024459676817059517,-0.0675913468003273,-0.05609077960252762
+lymphoid,Mpo,Cpa3,0.024223722517490387,0.024223722517490387,-0.10126742720603943,0.09760438650846481
+lymphoid,Itga2b,Hlf,-0.024222802370786667,0.024222802370786667,-0.0675913468003273,-0.06686992198228836
+megakaryocyte,Pf4,Cpa3,-0.003881219308823347,0.003881219308823347,1.1710466146469116,0.35562050342559814
+megakaryocyte,Pf4,Mpo,0.003156508319079876,0.003156508319079876,1.1710466146469116,0.4845854640007019
+megakaryocyte,Ctss,Cpa3,-0.002814503386616707,0.002814503386616707,-0.7294644713401794,0.35562050342559814
+megakaryocyte,Pf4,Klf1,0.0021696193143725395,0.0021696193143725395,1.1710466146469116,-0.34734171628952026
+megakaryocyte,Pf4,Car1,0.0021380058024078608,0.0021380058024078608,1.1710466146469116,-0.31214332580566406
+megakaryocyte,Cpa3,Klf1,0.0020554966758936644,0.0020554966758936644,0.35562050342559814,-0.34734171628952026
+megakaryocyte,Elane,Cpa3,-0.0018362507689744234,0.0018362507689744234,0.4230068027973175,0.35562050342559814
+megakaryocyte,Pf4,Meis1,0.001790807582437992,0.001790807582437992,1.1710466146469116,0.2730121612548828
+megakaryocyte,Pf4,Il7r,-0.001790400710888207,0.001790400710888207,1.1710466146469116,-0.38151222467422485
+megakaryocyte,Mmp8,Elane,-0.0017317697638645768,0.0017317697638645768,-0.6894614100456238,0.4230068027973175
+megakaryocyte,Mpo,Elane,0.001701543340459466,0.001701543340459466,0.4845854640007019,0.4230068027973175
+megakaryocyte,Wfdc17,Cpa3,-0.0016913029830902815,0.0016913029830902815,-0.7437719702720642,0.35562050342559814
+megakaryocyte,Mpo,Cpa3,0.0014831011649221182,0.0014831011649221182,0.4845854640007019,0.35562050342559814
+megakaryocyte,Mpo,Car1,-0.0013630716130137444,0.0013630716130137444,0.4845854640007019,-0.31214332580566406
+megakaryocyte,Mmp8,Cpa3,-0.0013464861549437046,0.0013464861549437046,-0.6894614100456238,0.35562050342559814
+megakaryocyte,Wfdc17,Klf1,0.0013257656246423721,0.0013257656246423721,-0.7437719702720642,-0.34734171628952026
+megakaryocyte,Wfdc17,Il7r,-0.0013053743168711662,0.0013053743168711662,-0.7437719702720642,-0.38151222467422485
+megakaryocyte,Pf4,Wfdc17,-0.0013022199273109436,0.0013022199273109436,1.1710466146469116,-0.7437719702720642
+megakaryocyte,Pf4,Ms4a2,-0.0012873782543465495,0.0012873782543465495,1.1710466146469116,0.26966506242752075
+megakaryocyte,Elane,Klf1,0.0012780068209394813,0.0012780068209394813,0.4230068027973175,-0.34734171628952026
+megakaryocyte,Pf4,Ctss,-0.0012431212235242128,0.0012431212235242128,1.1710466146469116,-0.7294644713401794
+megakaryocyte,Csf1r,Elane,-0.0012408869806677103,0.0012408869806677103,-0.5307282209396362,0.4230068027973175
+megakaryocyte,Il7r,Klf1,0.001235290546901524,0.001235290546901524,-0.38151222467422485,-0.34734171628952026
+megakaryocyte,Wfdc17,Mmp8,-0.0012278250651434064,0.0012278250651434064,-0.7437719702720642,-0.6894614100456238
+megakaryocyte,Il7r,Cpa3,-0.0011797088664025068,0.0011797088664025068,-0.38151222467422485,0.35562050342559814
+megakaryocyte,Ctss,Il7r,-0.0011698968010023236,0.0011698968010023236,-0.7294644713401794,-0.38151222467422485
+megakaryocyte,Ctss,Elane,-0.001168771181255579,0.001168771181255579,-0.7294644713401794,0.4230068027973175
+megakaryocyte,Elane,Meis1,0.0011489882599562407,0.0011489882599562407,0.4230068027973175,0.2730121612548828
+megakaryocyte,Ctss,Klf1,0.0010526428231969476,0.0010526428231969476,-0.7294644713401794,-0.34734171628952026
+megakaryocyte,Mpo,Il7r,0.0010468506952747703,0.0010468506952747703,0.4845854640007019,-0.38151222467422485
+myeloid,Elane,Mmp8,-0.3946418762207031,0.3946418762207031,0.31437763571739197,0.10030834376811981
+myeloid,Elane,Mpo,0.3223423659801483,0.3223423659801483,0.31437763571739197,0.27571824193000793
+myeloid,Itga2b,Mmp8,0.16349419951438904,0.16349419951438904,-0.3113039433956146,0.10030834376811981
+myeloid,Mpo,Sell,-0.16335459053516388,0.16335459053516388,0.27571824193000793,0.1602097451686859
+myeloid,Elane,Sell,0.15524563193321228,0.15524563193321228,0.31437763571739197,0.1602097451686859
+myeloid,Cpa3,Mmp8,0.1541890650987625,0.1541890650987625,-0.398151159286499,0.10030834376811981
+myeloid,Elane,Meis1,-0.1389431357383728,0.1389431357383728,0.31437763571739197,-0.1983843445777893
+myeloid,Ms4a2,Mpo,0.13255524635314941,0.13255524635314941,-0.36846357583999634,0.27571824193000793
+myeloid,Elane,Hlf,0.13062092661857605,0.13062092661857605,0.31437763571739197,-0.15231692790985107
+myeloid,Elane,Il7r,-0.12156989425420761,0.12156989425420761,0.31437763571739197,-0.0728289932012558
+myeloid,Sell,Mmp8,0.10701091587543488,0.10701091587543488,0.1602097451686859,0.10030834376811981
+myeloid,Mmp8,Wfdc17,0.10277840495109558,0.10277840495109558,0.10030834376811981,0.06580036878585815
+myeloid,Hlf,Mmp8,-0.10029034316539764,0.10029034316539764,-0.15231692790985107,0.10030834376811981
+myeloid,Itga2b,Sell,-0.09674398601055145,0.09674398601055145,-0.3113039433956146,0.1602097451686859
+myeloid,Cpa3,Meis1,0.09473128616809845,0.09473128616809845,-0.398151159286499,-0.1983843445777893
+myeloid,Il7r,Wfdc17,0.09463903307914734,0.09463903307914734,-0.0728289932012558,0.06580036878585815
+myeloid,Ms4a2,Mmp8,0.09329677373170853,0.09329677373170853,-0.36846357583999634,0.10030834376811981
+myeloid,Cpa3,Itga2b,0.09223198145627975,0.09223198145627975,-0.398151159286499,-0.3113039433956146
+myeloid,Itga2b,Wfdc17,0.09219245612621307,0.09219245612621307,-0.3113039433956146,0.06580036878585815
+myeloid,Cpa3,Mpo,0.08420531451702118,0.08420531451702118,-0.398151159286499,0.27571824193000793
+myeloid,Ms4a2,Meis1,0.08354455232620239,0.08354455232620239,-0.36846357583999634,-0.1983843445777893
+myeloid,Meis1,Mmp8,0.07942895591259003,0.07942895591259003,-0.1983843445777893,0.10030834376811981
+myeloid,Cpa3,Ms4a2,0.07845260947942734,0.07845260947942734,-0.398151159286499,-0.36846357583999634
+myeloid,Mmp8,Il7r,0.07823354005813599,0.07823354005813599,0.10030834376811981,-0.0728289932012558
+myeloid,Mpo,Gata1,0.07634222507476807,0.07634222507476807,0.27571824193000793,-0.2637157142162323
+myeloid,Meis1,Wfdc17,0.06958194077014923,0.06958194077014923,-0.1983843445777893,0.06580036878585815
+myeloid,Cpa3,Wfdc17,0.06931351870298386,0.06931351870298386,-0.398151159286499,0.06580036878585815
+myeloid,Itga2b,Mllt3,0.06928353011608124,0.06928353011608124,-0.3113039433956146,-0.2860681712627411
+myeloid,Cpa3,Gata1,0.0688754990696907,0.0688754990696907,-0.398151159286499,-0.2637157142162323
+myeloid,Elane,Car2,-0.06885727494955063,0.06885727494955063,0.31437763571739197,0.08658941835165024
+unassigned,Car1,Klf1,-0.009271062910556793,0.009271062910556793,-0.17356714606285095,-0.14668500423431396
+unassigned,Pf4,Flt3,0.008558233268558979,0.008558233268558979,-0.12810386717319489,0.1276523917913437
+unassigned,Slamf1,Pf4,0.007329271640628576,0.007329271640628576,0.14264613389968872,-0.12810386717319489
+unassigned,Klf1,Dntt,-0.006566631142050028,0.006566631142050028,-0.14668500423431396,0.11519181728363037
+unassigned,Car1,Dntt,-0.005974377039819956,0.005974377039819956,-0.17356714606285095,0.11519181728363037
+unassigned,Hlf,Dntt,-0.0054477970115840435,0.0054477970115840435,0.11904775351285934,0.11519181728363037
+unassigned,Flt3,Dntt,-0.005278157070279121,0.005278157070279121,0.1276523917913437,0.11519181728363037
+unassigned,Pf4,Dntt,0.003821416525170207,0.003821416525170207,-0.12810386717319489,0.11519181728363037
+unassigned,Slamf1,Dntt,-0.0035401051864027977,0.0035401051864027977,0.14264613389968872,0.11519181728363037
+unassigned,Klf1,2017_9_CD45minus_TTTGGTTAGCTACCTA,0.003492041490972042,0.003492041490972042,-0.14668500423431396,0.13437850773334503
+unassigned,Slamf1,Flt3,-0.0025773956440389156,0.0025773956440389156,0.14264613389968872,0.1276523917913437
+unassigned,2017_9_CD45minus_TTTGGTTAGCTACCTA,Hlf,0.002540703397244215,0.002540703397244215,0.13437850773334503,0.11904775351285934
+unassigned,Car1,2017_9_CD45minus_TTTGGTTAGCTACCTA,0.0024409741163253784,0.0024409741163253784,-0.17356714606285095,0.13437850773334503
+unassigned,Klf1,Slamf1,0.00206485902890563,0.00206485902890563,-0.14668500423431396,0.14264613389968872
+unassigned,Car1,Pf4,0.0020203564781695604,0.0020203564781695604,-0.17356714606285095,-0.12810386717319489
+unassigned,Klf1,Hlf,0.001675549428910017,0.001675549428910017,-0.14668500423431396,0.11904775351285934
+unassigned,2017_9_CD45minus_GTGGGTCCATCGGTTA,Hlf,0.001605708384886384,0.001605708384886384,0.1193944439291954,0.11904775351285934
+unassigned,Pf4,2017_9_CD45minus_GCGGGTTTCTGAGGGA,-0.0015582283958792686,0.0015582283958792686,-0.12810386717319489,0.12108117341995239
+unassigned,Car1,2017_9_CD45minus_GTGTTAGTCCATGCTC,0.0015135767171159387,0.0015135767171159387,-0.17356714606285095,0.11364725232124329
+unassigned,2017_9_CD45minus_TTTGGTTAGCTACCTA,Flt3,0.0014685688074678183,0.0014685688074678183,0.13437850773334503,0.1276523917913437
+unassigned,Klf1,2017_9_CD45minus_GTGTTAGTCCATGCTC,0.0014226383063942194,0.0014226383063942194,-0.14668500423431396,0.11364725232124329
+unassigned,Klf1,2017_9_CD45minus_TCGTACCGTGTTCTTT,0.0014086272567510605,0.0014086272567510605,-0.14668500423431396,0.1217222511768341
+unassigned,Klf1,2017_9_CD45minus_TGGCGCAGTGATGCCC,0.0014039810048416257,0.0014039810048416257,-0.14668500423431396,0.12213581055402756
+unassigned,2017_9_CD45minus_TCGTACCGTGTTCTTT,Hlf,0.0014016319764778018,0.0014016319764778018,0.1217222511768341,0.11904775351285934
+unassigned,2017_9_CD45minus_GGGCATCGTCATTAGC,Hlf,0.0013607579749077559,0.0013607579749077559,0.13611535727977753,0.11904775351285934
+unassigned,Klf1,2017_9_CD45minus_GCGGGTTTCTGAGGGA,0.001309754909016192,0.001309754909016192,-0.14668500423431396,0.12108117341995239
+unassigned,Klf1,Pf4,0.0012663218658417463,0.0012663218658417463,-0.14668500423431396,-0.12810386717319489
+unassigned,Klf1,2017_9_CD45minus_TACTTACAGTATTGGA,0.001253829337656498,0.001253829337656498,-0.14668500423431396,0.1220669075846672
+unassigned,Car1,2017_9_CD45minus_TCGTACCGTGTTCTTT,0.0012455313699319959,0.0012455313699319959,-0.17356714606285095,0.1217222511768341
+unassigned,Car1,2017_9_CD45minus_TGGCGCAGTGATGCCC,0.0012372557539492846,0.0012372557539492846,-0.17356714606285095,0.12213581055402756

discovery/85_hematopoiesis_hessian_top20_genes.json

@@ -0,0 +1,178 @@
+{
+  "MPP": [
+    "Slamf1",
+    "Cd48",
+    "Meis1",
+    "Klf1",
+    "Flt3",
+    "Car1",
+    "Csf1r",
+    "Mllt3",
+    "Hlf",
+    "Mpo",
+    "Pf4",
+    "Itga2b",
+    "Il7r",
+    "Ctss",
+    "Elane",
+    "Procr",
+    "Mmp8",
+    "Gata1",
+    "Sell",
+    "Dntt"
+  ],
+  "UNK": [
+    "Sell",
+    "Csf1r",
+    "Wfdc17",
+    "Itga2b",
+    "Gata1",
+    "Mmp8",
+    "Gp1bb",
+    "Pf4",
+    "Elane",
+    "Mpo",
+    "Cpa3",
+    "Car1",
+    "Hlf",
+    "Meis1",
+    "Klf1",
+    "Ms4a2",
+    "Procr",
+    "Flt3",
+    "Cd48",
+    "Il7r"
+  ],
+  "basophil-mast": [
+    "Wfdc17",
+    "Mmp8",
+    "Csf1r",
+    "Ctss",
+    "Cpa3",
+    "Flt3",
+    "Sell",
+    "Klf1",
+    "Car1",
+    "Dntt",
+    "Ms4a2",
+    "Itga2b",
+    "Il7r",
+    "Elane",
+    "Hlf",
+    "Meis1",
+    "Mpo",
+    "Mllt3",
+    "Procr",
+    "Hba-a1"
+  ],
+  "erythroid": [
+    "Car2",
+    "Klf1",
+    "Car1",
+    "Mllt3",
+    "Meis1",
+    "Hba-a1",
+    "Flt3",
+    "Slamf1",
+    "Hlf",
+    "Mmp8",
+    "Cpa3",
+    "Wfdc17",
+    "Ctss",
+    "Gata1",
+    "Cd48",
+    "Pf4",
+    "Gp1bb",
+    "Csf1r",
+    "Mpo",
+    "Dntt"
+  ],
+  "lymphoid": [
+    "Slamf1",
+    "Gp1bb",
+    "Mllt3",
+    "Meis1",
+    "Elane",
+    "Mpo",
+    "Cpa3",
+    "Csf1r",
+    "Klf1",
+    "Mmp8",
+    "Itga2b",
+    "Hlf",
+    "Sell",
+    "Pf4",
+    "Car2",
+    "Wfdc17",
+    "Dntt",
+    "Cd48",
+    "Procr",
+    "Flt3"
+  ],
+  "megakaryocyte": [
+    "Pf4",
+    "Gp1bb",
+    "Itga2b",
+    "Wfdc17",
+    "Ctss",
+    "Mmp8",
+    "Gata1",
+    "Csf1r",
+    "Mpo",
+    "Elane",
+    "Il7r",
+    "Slamf1",
+    "Cpa3",
+    "Klf1",
+    "Car1",
+    "Meis1",
+    "Ms4a2",
+    "Flt3",
+    "Hlf",
+    "Dntt"
+  ],
+  "myeloid": [
+    "Cpa3",
+    "Ms4a2",
+    "Elane",
+    "Itga2b",
+    "Mllt3",
+    "Mpo",
+    "Gata1",
+    "Car1",
+    "Klf1",
+    "Meis1",
+    "Sell",
+    "Hlf",
+    "Flt3",
+    "Dntt",
+    "Mmp8",
+    "Slamf1",
+    "Car2",
+    "Il7r",
+    "Wfdc17",
+    "Gp1bb"
+  ],
+  "unassigned": [
+    "Car1",
+    "Klf1",
+    "Slamf1",
+    "2017_9_CD45minus_GGGCATCGTCATTAGC",
+    "2017_9_CD45minus_TTTGGTTAGCTACCTA",
+    "Pf4",
+    "Flt3",
+    "2017_9_CD45minus_GCGCGATGTGCGCTTG",
+    "2017_9_CD45minus_TGGCGCAGTGATGCCC",
+    "2017_9_CD45minus_TACTTACAGTATTGGA",
+    "2017_9_CD45minus_TCGTACCGTGTTCTTT",
+    "2017_9_CD45minus_GCGGGTTTCTGAGGGA",
+    "2017_9_CD45minus_TATCTCAGTCTCCCTA",
+    "2017_9_CD45minus_GTGGGTCCATCGGTTA",
+    "Hlf",
+    "2017_9_CD45minus_GCGCGATAGATGCCTT",
+    "Dntt",
+    "2017_9_CD45minus_GGAATAAAGTTTGCGT",
+    "2017_9_CD45minus_GTGTTAGTCCATGCTC",
+    "2017_9_CD45minus_TTCTTAGTCCTGCCAT"
+  ]
+}

discovery/85_pan_skin_hessian_pairs.csv

@@ -0,0 +1,721 @@
+class,gene_a,gene_b,hessian_off_diag,abs_h,attribution_a,attribution_b
+HF-DP,Bmp4,Egfl6,1.0429026588099077e-05,1.0429026588099077e-05,-0.39599740505218506,0.3261866271495819
+HF-DP,Sfrp5,Egfl6,9.190198397845961e-06,9.190198397845961e-06,0.342842161655426,0.3261866271495819
+HF-DP,Sfrp5,Fam180a,-9.014700481202453e-06,9.014700481202453e-06,0.342842161655426,-0.30978626012802124
+HF-DP,Bmp4,Fam180a,-8.52568609843729e-06,8.52568609843729e-06,-0.39599740505218506,-0.30978626012802124
+HF-DP,Bmp4,Sfrp5,-8.516794878232758e-06,8.516794878232758e-06,-0.39599740505218506,0.342842161655426
+HF-DP,Actc1,Egfl6,-8.27859912533313e-06,8.27859912533313e-06,-0.3311654031276703,0.3261866271495819
+HF-DP,Itih5,Egfl6,-7.1294689405476674e-06,7.1294689405476674e-06,0.4735632836818695,0.3261866271495819
+HF-DP,Dkk2,Atp1a2,-7.071726940921508e-06,7.071726940921508e-06,-0.3604532480239868,-0.3353389501571655
+HF-DP,Itih5,Bmp4,6.9647858254029416e-06,6.9647858254029416e-06,0.4735632836818695,-0.39599740505218506
+HF-DP,Actc1,Grem2,6.84534552419791e-06,6.84534552419791e-06,-0.3311654031276703,0.30510422587394714
+HF-DP,Atp1a2,Fam180a,-6.840518835815601e-06,6.840518835815601e-06,-0.3353389501571655,-0.30978626012802124
+HF-DP,Dkk2,Penk,6.7548071456258185e-06,6.7548071456258185e-06,-0.3604532480239868,0.3032676577568054
+HF-DP,Egfl6,Fam180a,6.582491550943814e-06,6.582491550943814e-06,0.3261866271495819,-0.30978626012802124
+HF-DP,Egfl6,Edn3,6.01683041168144e-06,6.01683041168144e-06,0.3261866271495819,-0.32157841324806213
+HF-DP,Atp1a2,Cyp2f2,-5.9971894188493025e-06,5.9971894188493025e-06,-0.3353389501571655,-0.3279629945755005
+HF-DP,Dkk2,Cyp2f2,-5.895366484764963e-06,5.895366484764963e-06,-0.3604532480239868,-0.3279629945755005
+HF-DP,Sfrp5,Actc1,5.489884642884135e-06,5.489884642884135e-06,0.342842161655426,-0.3311654031276703
+HF-DP,Itih5,Actc1,-5.476523256220389e-06,5.476523256220389e-06,0.4735632836818695,-0.3311654031276703
+HF-DP,Ltbp1,Egfl6,5.4706342780264094e-06,5.4706342780264094e-06,-0.33905652165412903,0.3261866271495819
+HF-DP,Fam180a,Grem2,-5.2426512411329895e-06,5.2426512411329895e-06,-0.30978626012802124,0.30510422587394714
+HF-DP,Itih5,Sfrp5,5.155699000169989e-06,5.155699000169989e-06,0.4735632836818695,0.342842161655426
+HF-DP,Itih5,Ltbp1,5.108898221806157e-06,5.108898221806157e-06,0.4735632836818695,-0.33905652165412903
+HF-DP,Fam180a,Cilp,-5.063663593318779e-06,5.063663593318779e-06,-0.30978626012802124,-0.3089568018913269
+HF-DP,Sfrp5,Atp1a2,-5.0125818233937025e-06,5.0125818233937025e-06,0.342842161655426,-0.3353389501571655
+HF-DP,Atp1a2,Cilp,-4.977003300155047e-06,4.977003300155047e-06,-0.3353389501571655,-0.3089568018913269
+HF-DP,Sfrp5,Cilp,-4.910853931505699e-06,4.910853931505699e-06,0.342842161655426,-0.3089568018913269
+HF-DP,Fam180a,Penk,4.90546835862915e-06,4.90546835862915e-06,-0.30978626012802124,0.3032676577568054
+HF-DP,Cdh15,Grem2,4.830232228414388e-06,4.830232228414388e-06,-0.33105137944221497,0.30510422587394714
+HF-DP,Sfrp5,Cdh15,4.825541054742644e-06,4.825541054742644e-06,0.342842161655426,-0.33105137944221497
+HF-DP,Atp1a2,Serpina3c,-4.805424396181479e-06,4.805424396181479e-06,-0.3353389501571655,-0.30427655577659607
+HF-ORS,H2-Aa,H2-Ab1,-8.746000821702182e-05,8.746000821702182e-05,0.23931989073753357,0.22843529284000397
+HF-ORS,H2-Eb1,H2-Ab1,-8.575341780669987e-05,8.575341780669987e-05,0.23593616485595703,0.22843529284000397
+HF-ORS,H2-Aa,H2-Eb1,-8.412912575295195e-05,8.412912575295195e-05,0.23931989073753357,0.23593616485595703
+HF-ORS,Fcer1g,Plek,-7.013077265582979e-05,7.013077265582979e-05,0.25820231437683105,0.24382621049880981
+HF-ORS,Fcer1g,H2-Ab1,-6.53652532491833e-05,6.53652532491833e-05,0.25820231437683105,0.22843529284000397
+HF-ORS,Ly6g6e,AI607873,6.12170624663122e-05,6.12170624663122e-05,0.24607093632221222,0.2430092841386795
+HF-ORS,Fcer1g,H2-Aa,-6.049347575753927e-05,6.049347575753927e-05,0.25820231437683105,0.23931989073753357
+HF-ORS,Fcer1g,H2-Eb1,-5.941346535109915e-05,5.941346535109915e-05,0.25820231437683105,0.23593616485595703
+HF-ORS,Ly6g6e,Plek,-5.891008913749829e-05,5.891008913749829e-05,0.24607093632221222,0.24382621049880981
+HF-ORS,Fcer1g,Lilr4b,-5.587054693023674e-05,5.587054693023674e-05,0.25820231437683105,0.22519156336784363
+HF-ORS,Tyrobp,Ly6g6e,-5.5571214033989236e-05,5.5571214033989236e-05,0.2534595727920532,0.24607093632221222
+HF-ORS,Lilrb4a,Fcer1g,-5.07692493556533e-05,5.07692493556533e-05,0.25873449444770813,0.25820231437683105
+HF-ORS,Fcer1g,Tyrobp,-5.054502616985701e-05,5.054502616985701e-05,0.25820231437683105,0.2534595727920532
+HF-ORS,Alox5ap,Ly6g6e,-5.031092950957827e-05,5.031092950957827e-05,0.24662071466445923,0.24607093632221222
+HF-ORS,Ly6g6e,Csf1r,-4.9985443183686584e-05,4.9985443183686584e-05,0.24607093632221222,0.23392485082149506
+HF-ORS,Fcer1g,Cd86,-4.9381644203094766e-05,4.9381644203094766e-05,0.25820231437683105,0.23427385091781616
+HF-ORS,Fcer1g,Ly6g6e,-4.8893816710915416e-05,4.8893816710915416e-05,0.25820231437683105,0.24607093632221222
+HF-ORS,H2-Aa,Cd86,-4.864120273850858e-05,4.864120273850858e-05,0.23931989073753357,0.23427385091781616
+HF-ORS,H2-Eb1,Cd86,-4.858345346292481e-05,4.858345346292481e-05,0.23593616485595703,0.23427385091781616
+HF-ORS,Lilrb4a,Lilr4b,-4.686365355155431e-05,4.686365355155431e-05,0.25873449444770813,0.22519156336784363
+HF-ORS,Cd86,H2-Ab1,-4.67113422928378e-05,4.67113422928378e-05,0.23427385091781616,0.22843529284000397
+HF-ORS,Plek,Lilr4b,-4.591018659994006e-05,4.591018659994006e-05,0.24382621049880981,0.22519156336784363
+HF-ORS,Lilrb4a,Plek,-4.491160507313907e-05,4.491160507313907e-05,0.25873449444770813,0.24382621049880981
+HF-ORS,Fcer1g,Alox5ap,-4.3427833588793874e-05,4.3427833588793874e-05,0.25820231437683105,0.24662071466445923
+HF-ORS,Lilrb4a,Ly6g6e,-4.3309457396389917e-05,4.3309457396389917e-05,0.25873449444770813,0.24607093632221222
+HF-ORS,Cd86,Ccl9,4.100346632185392e-05,4.100346632185392e-05,0.23427385091781616,0.22468113899230957
+HF-ORS,H2-Eb1,Ccl9,4.048252958455123e-05,4.048252958455123e-05,0.23593616485595703,0.22468113899230957
+HF-ORS,H2-Ab1,Ccl9,3.995086808572523e-05,3.995086808572523e-05,0.22843529284000397,0.22468113899230957
+HF-ORS,H2-Aa,Ccl9,3.9888120227260515e-05,3.9888120227260515e-05,0.23931989073753357,0.22468113899230957
+HF-ORS,Tyrobp,Plek,-3.881721931975335e-05,3.881721931975335e-05,0.2534595727920532,0.24382621049880981
+HF-placode,Lhx2,Trp63,1.59217270265799e-05,1.59217270265799e-05,-0.5085378885269165,-0.4255644679069519
+HF-placode,Urah,Golga7b,1.5566158253932372e-05,1.5566158253932372e-05,-0.3443412184715271,-0.3443027138710022
+HF-placode,Urah,Ptch2,1.4554567314917222e-05,1.4554567314917222e-05,-0.3443412184715271,-0.3388559818267822
+HF-placode,Igsf9,Urah,1.2394926670822315e-05,1.2394926670822315e-05,-0.3546642065048218,-0.3443412184715271
+HF-placode,Golga7b,Dlk2,-1.1799646017607301e-05,1.1799646017607301e-05,-0.3443027138710022,-0.3373790979385376
+HF-placode,Urah,Wnt6,1.166388210549485e-05,1.166388210549485e-05,-0.3443412184715271,-0.33890730142593384
+HF-placode,Wnt6,Ckmt1,1.042011717800051e-05,1.042011717800051e-05,-0.33890730142593384,-0.334733784198761
+HF-placode,Golga7b,Ptch2,1.0292973456671461e-05,1.0292973456671461e-05,-0.3443027138710022,-0.3388559818267822
+HF-placode,Wnt10a,Dlk2,1.0162434591620695e-05,1.0162434591620695e-05,-0.347310334444046,-0.3373790979385376
+HF-placode,Atp6v1b1,Urah,1.0161789759877138e-05,1.0161789759877138e-05,-0.4007054567337036,-0.3443412184715271
+HF-placode,Ptch2,Ckmt1,1.0128840585821308e-05,1.0128840585821308e-05,-0.3388559818267822,-0.334733784198761
+HF-placode,Lhx2,Fermt1,1.0112213203683496e-05,1.0112213203683496e-05,-0.5085378885269165,-0.37771734595298767
+HF-placode,Trp63,Ptch2,9.877861884888262e-06,9.877861884888262e-06,-0.4255644679069519,-0.3388559818267822
+HF-placode,Lmo1,Urah,9.702140232548118e-06,9.702140232548118e-06,-0.522371232509613,-0.3443412184715271
+HF-placode,Trp63,Golga7b,9.616792340239044e-06,9.616792340239044e-06,-0.4255644679069519,-0.3443027138710022
+HF-placode,Dlk2,Cbr2,9.114011845667847e-06,9.114011845667847e-06,-0.3373790979385376,-0.3317171037197113
+HF-placode,Lhx2,Cbr2,9.101454452320468e-06,9.101454452320468e-06,-0.5085378885269165,-0.3317171037197113
+HF-placode,Golga7b,Ckmt1,8.771101420279592e-06,8.771101420279592e-06,-0.3443027138710022,-0.334733784198761
+HF-placode,Lamc2,Cbr2,8.386912668356672e-06,8.386912668356672e-06,-0.35767602920532227,-0.3317171037197113
+HF-placode,Lhx2,Lgr6,8.124925443553366e-06,8.124925443553366e-06,-0.5085378885269165,-0.3464205265045166
+HF-placode,Lmo1,Golga7b,8.098551006696653e-06,8.098551006696653e-06,-0.522371232509613,-0.3443027138710022
+HF-placode,Atp6v1b1,Golga7b,7.873341019148938e-06,7.873341019148938e-06,-0.4007054567337036,-0.3443027138710022
+HF-placode,Trp63,Atp6v1b1,7.642094715265557e-06,7.642094715265557e-06,-0.4255644679069519,-0.4007054567337036
+HF-placode,Lmo1,Ckmt1,7.55591372580966e-06,7.55591372580966e-06,-0.522371232509613,-0.334733784198761
+HF-placode,Ptch2,Dlk2,-7.421158443321474e-06,7.421158443321474e-06,-0.3388559818267822,-0.3373790979385376
+HF-placode,Urah,Cbr2,-7.3070605139946565e-06,7.3070605139946565e-06,-0.3443412184715271,-0.3317171037197113
+HF-placode,Lmo1,Wnt6,7.226867637655232e-06,7.226867637655232e-06,-0.522371232509613,-0.33890730142593384
+HF-placode,Igsf9,Ckmt1,7.093287422321737e-06,7.093287422321737e-06,-0.3546642065048218,-0.334733784198761
+HF-placode,Lamc2,Dlk2,7.065870249789441e-06,7.065870249789441e-06,-0.35767602920532227,-0.3373790979385376
+HF-placode,Igsf9,Dlk2,-6.932497853995301e-06,6.932497853995301e-06,-0.3546642065048218,-0.3373790979385376
+UNK,Selplg,Cd3g,-0.00015580980107188225,0.00015580980107188225,0.6861708760261536,0.6837731599807739
+UNK,Cd52,Cd3g,-0.0001437013124814257,0.0001437013124814257,0.7724283933639526,0.6837731599807739
+UNK,Cd52,Selplg,-0.00013170299644116312,0.00013170299644116312,0.7724283933639526,0.6861708760261536
+UNK,Coro1a,Cd3g,-0.00012494539259932935,0.00012494539259932935,0.7863627672195435,0.6837731599807739
+UNK,Cd3g,Bin2,-0.00012029707431793213,0.00012029707431793213,0.6837731599807739,0.6477911472320557
+UNK,Coro1a,Selplg,-0.00010810268577188253,0.00010810268577188253,0.7863627672195435,0.6861708760261536
+UNK,Hmha1,Selplg,-0.00010708007903303951,0.00010708007903303951,0.8664606809616089,0.6861708760261536
+UNK,Fxyd5,Cd3g,-0.00010641694825608283,0.00010641694825608283,0.6838746070861816,0.6837731599807739
+UNK,Hmha1,Cd3g,-0.00010402348561910912,0.00010402348561910912,0.8664606809616089,0.6837731599807739
+UNK,Ptprcap,Selplg,-0.00010057866893475875,0.00010057866893475875,0.6977274417877197,0.6861708760261536
+UNK,Hmha1,Cd52,-9.6494986792095e-05,9.6494986792095e-05,0.8664606809616089,0.7724283933639526
+UNK,Ptprcap,Cd3g,-9.565680375089869e-05,9.565680375089869e-05,0.6977274417877197,0.6837731599807739
+UNK,Coro1a,Cd52,-9.480887820245698e-05,9.480887820245698e-05,0.7863627672195435,0.7724283933639526
+UNK,Cd3g,Il2rg,-9.39064339036122e-05,9.39064339036122e-05,0.6837731599807739,0.6617957353591919
+UNK,Cd52,Ptprcap,-9.232571756001562e-05,9.232571756001562e-05,0.7724283933639526,0.6977274417877197
+UNK,Rac2,Cd3g,-9.153473365586251e-05,9.153473365586251e-05,0.8427550792694092,0.6837731599807739
+UNK,Selplg,Fxyd5,-9.023006714414805e-05,9.023006714414805e-05,0.6861708760261536,0.6838746070861816
+UNK,Hcls1,Cd3g,-8.803002128843218e-05,8.803002128843218e-05,0.7175995707511902,0.6837731599807739
+UNK,Selplg,Il2rg,-8.031323523027822e-05,8.031323523027822e-05,0.6861708760261536,0.6617957353591919
+UNK,Selplg,Bin2,-7.859741162974387e-05,7.859741162974387e-05,0.6861708760261536,0.6477911472320557
+UNK,Cd52,Il2rg,-7.791230746079236e-05,7.791230746079236e-05,0.7724283933639526,0.6617957353591919
+UNK,Cd52,Bin2,-7.784987974446267e-05,7.784987974446267e-05,0.7724283933639526,0.6477911472320557
+UNK,Coro1a,Ptprcap,-7.700057176407427e-05,7.700057176407427e-05,0.7863627672195435,0.6977274417877197
+UNK,Cd52,Fxyd5,-7.545360131189227e-05,7.545360131189227e-05,0.7724283933639526,0.6838746070861816
+UNK,Fcer1g,Cd3g,7.477642793674022e-05,7.477642793674022e-05,0.6912468075752258,0.6837731599807739
+UNK,Ctsw,Selplg,-7.376060239039361e-05,7.376060239039361e-05,0.6891497373580933,0.6861708760261536
+UNK,Hmha1,Coro1a,-7.142585673136637e-05,7.142585673136637e-05,0.8664606809616089,0.7863627672195435
+UNK,Nkg7,Cd3g,6.994046998443082e-05,6.994046998443082e-05,0.6911388635635376,0.6837731599807739
+UNK,Coro1a,Il2rg,-6.435372779378667e-05,6.435372779378667e-05,0.7863627672195435,0.6617957353591919
+UNK,Cd52,Ctsw,-6.329132884275168e-05,6.329132884275168e-05,0.7724283933639526,0.6891497373580933
+basal-IFE,Cox8b,Car3,-0.0010510093998163939,0.0010510093998163939,0.6908206343650818,0.6228627562522888
+basal-IFE,Mt2,Cox8b,0.0007582143880426884,0.0007582143880426884,-0.6989928483963013,0.6908206343650818
+basal-IFE,Cox8b,Trp63,0.0006335391663014889,0.0006335391663014889,0.6908206343650818,-0.6211553812026978
+basal-IFE,Lmo1,Cox8b,0.0005479324026964605,0.0005479324026964605,-0.7080071568489075,0.6908206343650818
+basal-IFE,Mt2,Car3,0.000540885201189667,0.000540885201189667,-0.6989928483963013,0.6228627562522888
+basal-IFE,Car3,Trp63,0.0005239177262410522,0.0005239177262410522,0.6228627562522888,-0.6211553812026978
+basal-IFE,Lmo1,Car3,0.00040242524119094014,0.00040242524119094014,-0.7080071568489075,0.6228627562522888
+basal-IFE,Car3,Nnat,-0.0003552451962605119,0.0003552451962605119,0.6228627562522888,0.6053619980812073
+basal-IFE,Mt2,Trp63,-0.00033464108128100634,0.00033464108128100634,-0.6989928483963013,-0.6211553812026978
+basal-IFE,Cox8b,Ccl11,0.00033103779423981905,0.00033103779423981905,0.6908206343650818,-0.6408882737159729
+basal-IFE,Nnat,Actc1,0.0003024941252078861,0.0003024941252078861,0.6053619980812073,0.5800741910934448
+basal-IFE,Lmo1,Trp63,-0.00026803973014466465,0.00026803973014466465,-0.7080071568489075,-0.6211553812026978
+basal-IFE,Cox8b,Nnat,-0.0002674866118468344,0.0002674866118468344,0.6908206343650818,0.6053619980812073
+basal-IFE,Mt2,Ccl11,-0.0002645443892106414,0.0002645443892106414,-0.6989928483963013,-0.6408882737159729
+basal-IFE,Cox8b,Pcolce2,-0.00025330629432573915,0.00025330629432573915,0.6908206343650818,-0.6676270365715027
+basal-IFE,Trp63,Nnat,0.0002528757322579622,0.0002528757322579622,-0.6211553812026978,0.6053619980812073
+basal-IFE,Serpina3n,Mt2,-0.00024697082699276507,0.00024697082699276507,-0.7243701219558716,-0.6989928483963013
+basal-IFE,Lmo1,Mt2,-0.00023694589617662132,0.00023694589617662132,-0.7080071568489075,-0.6989928483963013
+basal-IFE,Bcam,Car3,-0.00023071118630468845,0.00023071118630468845,-0.6519873142242432,0.6228627562522888
+basal-IFE,Serpina3n,Actc1,0.00022604738478548825,0.00022604738478548825,-0.7243701219558716,0.5800741910934448
+basal-IFE,Htra3,Actc1,-0.00022358671412803233,0.00022358671412803233,-0.5855591297149658,0.5800741910934448
+basal-IFE,Serpina3n,Nnat,0.00022196746431291103,0.00022196746431291103,-0.7243701219558716,0.6053619980812073
+basal-IFE,Rnase4,Actc1,-0.00022157761850394309,0.00022157761850394309,-0.64029860496521,0.5800741910934448
+basal-IFE,Serpina3n,Cox8b,0.0002076922683045268,0.0002076922683045268,-0.7243701219558716,0.6908206343650818
+basal-IFE,Ccl11,Car3,0.00020057469373568892,0.00020057469373568892,-0.6408882737159729,0.6228627562522888
+basal-IFE,Pcolce2,Car3,-0.00020053194020874798,0.00020053194020874798,-0.6676270365715027,0.6228627562522888
+basal-IFE,Cox8b,Bcam,-0.00019670059555210173,0.00019670059555210173,0.6908206343650818,-0.6519873142242432
+basal-IFE,Gas6,Cox8b,0.00019013698329217732,0.00019013698329217732,-0.6995038986206055,0.6908206343650818
+basal-IFE,Rnase4,Nnat,-0.00018175672448705882,0.00018175672448705882,-0.64029860496521,0.6053619980812073
+basal-IFE,Nnat,Htra3,-0.00017448284779675305,0.00017448284779675305,0.6053619980812073,-0.5855591297149658
+basal-multipotent,Dsg1a,Calm5,0.0031688078306615353,0.0031688078306615353,-0.06492150574922562,-0.06490492075681686
+basal-multipotent,Dsg1a,Calm4,0.0030041802674531937,0.0030041802674531937,-0.06492150574922562,-0.06039052456617355
+basal-multipotent,Calm5,Calm4,0.002922873944044113,0.002922873944044113,-0.06490492075681686,-0.06039052456617355
+basal-multipotent,Dsg1a,Oas1f,0.002800961257889867,0.002800961257889867,-0.06492150574922562,-0.057981155812740326
+basal-multipotent,Fam25c,Dsg1a,0.002716898452490568,0.002716898452490568,-0.0775643065571785,-0.06492150574922562
+basal-multipotent,Calm5,Oas1f,0.002648551482707262,0.002648551482707262,-0.06490492075681686,-0.057981155812740326
+basal-multipotent,Calm4,Oas1f,0.0026019858196377754,0.0026019858196377754,-0.06039052456617355,-0.057981155812740326
+basal-multipotent,Fam25c,Calm5,0.002584518399089575,0.002584518399089575,-0.0775643065571785,-0.06490492075681686
+basal-multipotent,Fam25c,Calm4,0.0025320202112197876,0.0025320202112197876,-0.0775643065571785,-0.06039052456617355
+basal-multipotent,Fam25c,Oas1f,0.002343173371627927,0.002343173371627927,-0.0775643065571785,-0.057981155812740326
+basal-multipotent,Calm5,Pkib,0.0021935044787824154,0.0021935044787824154,-0.06490492075681686,-0.058426253497600555
+basal-multipotent,Dsg1a,Pkib,0.0021660542115569115,0.0021660542115569115,-0.06492150574922562,-0.058426253497600555
+basal-multipotent,Calm4,Pkib,0.002038313541561365,0.002038313541561365,-0.06039052456617355,-0.058426253497600555
+basal-multipotent,Dsg1a,Fcgbp,-0.0020258701406419277,0.0020258701406419277,-0.06492150574922562,-0.05795951187610626
+basal-multipotent,Pkib,Oas1f,0.0019435128197073936,0.0019435128197073936,-0.058426253497600555,-0.057981155812740326
+basal-multipotent,Fam25c,Pkib,0.0018688386771827936,0.0018688386771827936,-0.0775643065571785,-0.058426253497600555
+basal-multipotent,Calm5,Fcgbp,-0.001817793701775372,0.001817793701775372,-0.06490492075681686,-0.05795951187610626
+basal-multipotent,Calm4,Fcgbp,-0.0018146629445254803,0.0018146629445254803,-0.06039052456617355,-0.05795951187610626
+basal-multipotent,Calm5,Susd2,0.0018108375370502472,0.0018108375370502472,-0.06490492075681686,-0.05797836184501648
+basal-multipotent,Dsg1a,Susd2,0.0017885664710775018,0.0017885664710775018,-0.06492150574922562,-0.05797836184501648
+basal-multipotent,Calm4,Susd2,0.001722729648463428,0.001722729648463428,-0.06039052456617355,-0.05797836184501648
+basal-multipotent,Oas1f,Susd2,0.001670066500082612,0.001670066500082612,-0.057981155812740326,-0.05797836184501648
+basal-multipotent,Fam25c,Fcgbp,-0.0016049346886575222,0.0016049346886575222,-0.0775643065571785,-0.05795951187610626
+basal-multipotent,Fam25c,Susd2,0.0015710779698565602,0.0015710779698565602,-0.0775643065571785,-0.05797836184501648
+basal-multipotent,Oas1f,Fcgbp,-0.0015097453724592924,0.0015097453724592924,-0.057981155812740326,-0.05795951187610626
+basal-multipotent,Calm5,Alox12e,0.0013870794791728258,0.0013870794791728258,-0.06490492075681686,-0.06132492795586586
+basal-multipotent,Dsg1a,Alox12e,0.001277937088161707,0.001277937088161707,-0.06492150574922562,-0.06132492795586586
+basal-multipotent,Pkib,Fcgbp,-0.0012678041821345687,0.0012678041821345687,-0.058426253497600555,-0.05795951187610626
+basal-multipotent,Alox12e,Calm4,0.0012630114797502756,0.0012630114797502756,-0.06132492795586586,-0.06039052456617355
+basal-multipotent,Dsg1a,Defb6,-0.0012596303131431341,0.0012596303131431341,-0.06492150574922562,-0.058576278388500214
+dermal-condensate,Cidec,Lpl,-0.0019766706973314285,0.0019766706973314285,0.19857245683670044,0.13426588475704193
+dermal-condensate,Adipoq,Lpl,-0.0019652387127280235,0.0019652387127280235,0.2069810926914215,0.13426588475704193
+dermal-condensate,Cidea,Lpl,-0.0017194205429404974,0.0017194205429404974,0.16787847876548767,0.13426588475704193
+dermal-condensate,Lpl,Adig,-0.0016898198518902063,0.0016898198518902063,0.13426588475704193,0.1330370306968689
+dermal-condensate,Cox8b,Lpl,-0.0013977200724184513,0.0013977200724184513,0.2129272222518921,0.13426588475704193
+dermal-condensate,Lpl,Agt,-0.0013879886828362942,0.0013879886828362942,0.13426588475704193,0.12299869954586029
+dermal-condensate,Lpl,Gpd1,-0.0013774497201666236,0.0013774497201666236,0.13426588475704193,0.12458829581737518
+dermal-condensate,Car3,Lpl,-0.0012905256589874625,0.0012905256589874625,0.21634441614151,0.13426588475704193
+dermal-condensate,Pnpla2,Lpl,-0.0012540895259007812,0.0012540895259007812,0.1537400782108307,0.13426588475704193
+dermal-condensate,Lpl,Mrap,-0.001174370525404811,0.001174370525404811,0.13426588475704193,0.10546701401472092
+dermal-condensate,Chchd10,Lpl,-0.0011394884204491973,0.0011394884204491973,0.14114969968795776,0.13426588475704193
+dermal-condensate,Lpl,Retn,-0.001054060528986156,0.001054060528986156,0.13426588475704193,0.12092118710279465
+dermal-condensate,Lpl,Ppp1r1a,-0.0010470554698258638,0.0010470554698258638,0.13426588475704193,0.12309904396533966
+dermal-condensate,Cidea,Adig,-0.0010411529801785946,0.0010411529801785946,0.16787847876548767,0.1330370306968689
+dermal-condensate,Cidec,Cidea,-0.0010359962470829487,0.0010359962470829487,0.19857245683670044,0.16787847876548767
+dermal-condensate,Adipoq,Tpsb2,0.0009008454508148134,0.0009008454508148134,0.2069810926914215,0.11006689071655273
+dermal-condensate,Adipoq,Cidea,-0.0008905485738068819,0.0008905485738068819,0.2069810926914215,0.16787847876548767
+dermal-condensate,Car3,Tpsb2,0.0008851898601278663,0.0008851898601278663,0.21634441614151,0.11006689071655273
+dermal-condensate,Pnpla2,Tpsb2,0.00083341816207394,0.00083341816207394,0.1537400782108307,0.11006689071655273
+dermal-condensate,Lpl,8430408G22Rik,-0.0008332702564075589,0.0008332702564075589,0.13426588475704193,0.10827308148145676
+dermal-condensate,Car3,Cma1,0.0008214861154556274,0.0008214861154556274,0.21634441614151,0.1156621128320694
+dermal-condensate,Pnpla2,Cma1,0.0008129777852445841,0.0008129777852445841,0.1537400782108307,0.1156621128320694
+dermal-condensate,Cidea,Chchd10,-0.0008111898205243051,0.0008111898205243051,0.16787847876548767,0.14114969968795776
+dermal-condensate,Cidec,Tpsb2,0.0007920192438177764,0.0007920192438177764,0.19857245683670044,0.11006689071655273
+dermal-condensate,Cox8b,Tpsb2,0.0007871121051721275,0.0007871121051721275,0.2129272222518921,0.11006689071655273
+dermal-condensate,Cox8b,Cma1,0.0007768065552227199,0.0007768065552227199,0.2129272222518921,0.1156621128320694
+dermal-condensate,Car3,Pnpla2,0.0007732965750619769,0.0007732965750619769,0.21634441614151,0.1537400782108307
+dermal-condensate,Cidec,Adig,-0.0007458041654899716,0.0007458041654899716,0.19857245683670044,0.1330370306968689
+dermal-condensate,Cox8b,Cidea,-0.0007448750548064709,0.0007448750548064709,0.2129272222518921,0.16787847876548767
+dermal-condensate,Cidea,Gpd1,-0.0007413157145492733,0.0007413157145492733,0.16787847876548767,0.12458829581737518
+eccrine-duct,Cldn23,Alox12e,9.357926501252223e-06,9.357926501252223e-06,0.1584530472755432,-0.1428080052137375
+eccrine-duct,Cldn23,Skint9,6.9387315306812525e-06,6.9387315306812525e-06,0.1584530472755432,-0.15620046854019165
+eccrine-duct,Crabp1,Cldn23,-5.091361344966572e-06,5.091361344966572e-06,0.19521954655647278,0.1584530472755432
+eccrine-duct,Cldn23,Nrp1,-4.565268227452179e-06,4.565268227452179e-06,0.1584530472755432,0.15147528052330017
+eccrine-duct,Crabp1,Alox12e,4.02818841394037e-06,4.02818841394037e-06,0.19521954655647278,-0.1428080052137375
+eccrine-duct,Alox12e,Limch1,4.010801603726577e-06,4.010801603726577e-06,-0.1428080052137375,0.141269251704216
+eccrine-duct,Dkk2,Cox4i2,-3.965678843087517e-06,3.965678843087517e-06,0.1534293293952942,0.1486828774213791
+eccrine-duct,Cldn8,Alox12e,-3.878390543832211e-06,3.878390543832211e-06,0.1611148715019226,-0.1428080052137375
+eccrine-duct,Ppp2r2b,Cldn23,-3.8258222048170865e-06,3.8258222048170865e-06,0.25571292638778687,0.1584530472755432
+eccrine-duct,Nrp1,Alox12e,3.766825557249831e-06,3.766825557249831e-06,0.15147528052330017,-0.1428080052137375
+eccrine-duct,Cldn23,Cox4i2,-3.2864568311197218e-06,3.2864568311197218e-06,0.1584530472755432,0.1486828774213791
+eccrine-duct,Skint9,Limch1,3.2403881959908176e-06,3.2403881959908176e-06,-0.15620046854019165,0.141269251704216
+eccrine-duct,Cldn23,Limch1,-3.186437197655323e-06,3.186437197655323e-06,0.1584530472755432,0.141269251704216
+eccrine-duct,Cldn6,Cldn23,-3.1426579880644567e-06,3.1426579880644567e-06,0.25877025723457336,0.1584530472755432
+eccrine-duct,Skint9,Alox12e,-3.053254658880178e-06,3.053254658880178e-06,-0.15620046854019165,-0.1428080052137375
+eccrine-duct,Cldn8,Cldn23,2.866341674234718e-06,2.866341674234718e-06,0.1611148715019226,0.1584530472755432
+eccrine-duct,Crabp1,Limch1,-2.8311815185588785e-06,2.8311815185588785e-06,0.19521954655647278,0.141269251704216
+eccrine-duct,Cldn6,Limch1,-2.7911110009881668e-06,2.7911110009881668e-06,0.25877025723457336,0.141269251704216
+eccrine-duct,Ppp2r2b,Limch1,-2.7650125957734417e-06,2.7650125957734417e-06,0.25571292638778687,0.141269251704216
+eccrine-duct,Ppp2r2b,Nrp1,-2.6436291591380723e-06,2.6436291591380723e-06,0.25571292638778687,0.15147528052330017
+eccrine-duct,Cox4i2,Limch1,-2.6237723886879394e-06,2.6237723886879394e-06,0.1486828774213791,0.141269251704216
+eccrine-duct,Upk1b,Limch1,-2.5699941943457816e-06,2.5699941943457816e-06,0.23656737804412842,0.141269251704216
+eccrine-duct,Upk1b,Cldn23,-2.501598373783054e-06,2.501598373783054e-06,0.23656737804412842,0.1584530472755432
+eccrine-duct,Cldn6,Cldn8,2.500084065104602e-06,2.500084065104602e-06,0.25877025723457336,0.1611148715019226
+eccrine-duct,Gm266,Cldn23,-2.4714154278626665e-06,2.4714154278626665e-06,0.22945520281791687,0.1584530472755432
+eccrine-duct,Ppp2r2b,Cldn8,2.4532939733035164e-06,2.4532939733035164e-06,0.25571292638778687,0.1611148715019226
+eccrine-duct,Cldn23,Slc2a3,-2.4246733119070996e-06,2.4246733119070996e-06,0.1584530472755432,0.14222541451454163
+eccrine-duct,Wnt5a,Limch1,-2.395825504208915e-06,2.395825504208915e-06,0.15506772696971893,0.141269251704216
+eccrine-duct,Cldn6,Wnt5a,-2.316855898243375e-06,2.316855898243375e-06,0.25877025723457336,0.15506772696971893
+eccrine-duct,Cldn6,Nrp1,-2.298748313478427e-06,2.298748313478427e-06,0.25877025723457336,0.15147528052330017
+eccrine-ductal,Car3,Adipoq,0.001200112048536539,0.001200112048536539,-0.09149713814258575,-0.06429369747638702
+eccrine-ductal,Cox8b,Adipoq,0.0009320358512923121,0.0009320358512923121,-0.08961097151041031,-0.06429369747638702
+eccrine-ductal,Car3,Cox8b,0.0008856440545059741,0.0008856440545059741,-0.09149713814258575,-0.08961097151041031
+eccrine-ductal,Ccl11,Pcolce2,0.0008002641261555254,0.0008002641261555254,0.06619683653116226,0.06383912265300751
+eccrine-ductal,Serpina3n,Pcolce2,0.0005942605203017592,0.0005942605203017592,0.07036366313695908,0.06383912265300751
+eccrine-ductal,Serpina3n,Ccl11,0.0005900332471355796,0.0005900332471355796,0.07036366313695908,0.06619683653116226
+eccrine-ductal,Csf1r,Adipoq,0.0005574942333623767,0.0005574942333623767,0.06741055846214294,-0.06429369747638702
+eccrine-ductal,Car3,Pcolce2,0.0005151107325218618,0.0005151107325218618,-0.09149713814258575,0.06383912265300751
+eccrine-ductal,Adipoq,Pcolce2,0.0005068512400612235,0.0005068512400612235,-0.06429369747638702,0.06383912265300751
+eccrine-ductal,C1qa,C1qc,0.0004830588004551828,0.0004830588004551828,0.07170362770557404,0.07003848254680634
+eccrine-ductal,Cox8b,Pcolce2,0.0004662934225052595,0.0004662934225052595,-0.08961097151041031,0.06383912265300751
+eccrine-ductal,C1qc,C1qb,0.00045820855302736163,0.00045820855302736163,0.07003848254680634,0.06455620378255844
+eccrine-ductal,C1qa,C1qb,0.0004574713238980621,0.0004574713238980621,0.07170362770557404,0.06455620378255844
+eccrine-ductal,C1qc,Pf4,0.00042285045492462814,0.00042285045492462814,0.07003848254680634,0.06200774386525154
+eccrine-ductal,Car3,Csf1r,0.0004197400703560561,0.0004197400703560561,-0.09149713814258575,0.06741055846214294
+eccrine-ductal,C1qa,Pf4,0.0004192621854599565,0.0004192621854599565,0.07170362770557404,0.06200774386525154
+eccrine-ductal,C1qb,Pf4,0.00040801530121825635,0.00040801530121825635,0.06455620378255844,0.06200774386525154
+eccrine-ductal,Car3,Myl1,0.0003968872770201415,0.0003968872770201415,-0.09149713814258575,-0.06902870535850525
+eccrine-ductal,Cox8b,Csf1r,0.00038161806878633797,0.00038161806878633797,-0.08961097151041031,0.06741055846214294
+eccrine-ductal,C1qa,Ms4a7,0.00036997999995946884,0.00036997999995946884,0.07170362770557404,0.06359588354825974
+eccrine-ductal,C1qc,Ms4a7,0.0003666016273200512,0.0003666016273200512,0.07003848254680634,0.06359588354825974
+eccrine-ductal,C1qb,Ms4a7,0.0003609207342378795,0.0003609207342378795,0.06455620378255844,0.06359588354825974
+eccrine-ductal,Cox8b,Myl1,0.000347793655237183,0.000347793655237183,-0.08961097151041031,-0.06902870535850525
+eccrine-ductal,Car3,Ccl8,-0.0003463120374362916,0.0003463120374362916,-0.09149713814258575,0.06462445855140686
+eccrine-ductal,Ms4a7,Pf4,0.00034624841646291316,0.00034624841646291316,0.06359588354825974,0.06200774386525154
+eccrine-ductal,Ccl8,Adipoq,-0.00033899868139997125,0.00033899868139997125,0.06462445855140686,-0.06429369747638702
+eccrine-ductal,Cox8b,Ccl8,-0.00033281577634625137,0.00033281577634625137,-0.08961097151041031,0.06462445855140686
+eccrine-ductal,Myl1,Pcolce2,0.00032990440377034247,0.00032990440377034247,-0.06902870535850525,0.06383912265300751
+eccrine-ductal,C1qa,Adipoq,0.00032806250965222716,0.00032806250965222716,0.07170362770557404,-0.06429369747638702
+eccrine-ductal,C1qc,Adipoq,0.0002975273528136313,0.0002975273528136313,0.07003848254680634,-0.06429369747638702
+eccrine-placode,Adipoq,Cidec,-0.005375713109970093,0.005375713109970093,0.40856802463531494,0.39632177352905273
+eccrine-placode,Car3,Adipoq,-0.004778679460287094,0.004778679460287094,0.48335644602775574,0.40856802463531494
+eccrine-placode,Car3,Cidec,-0.004502394236624241,0.004502394236624241,0.48335644602775574,0.39632177352905273
+eccrine-placode,Adipoq,Adig,-0.0042462535202503204,0.0042462535202503204,0.40856802463531494,0.27328336238861084
+eccrine-placode,Car3,Cox8b,-0.004231535363942385,0.004231535363942385,0.48335644602775574,0.4755637049674988
+eccrine-placode,Cox8b,Adipoq,-0.004084560088813305,0.004084560088813305,0.4755637049674988,0.40856802463531494
+eccrine-placode,Cidec,Adig,-0.004010517615824938,0.004010517615824938,0.39632177352905273,0.27328336238861084
+eccrine-placode,Adipoq,Pnpla2,-0.004001593217253685,0.004001593217253685,0.40856802463531494,0.32516807317733765
+eccrine-placode,Cox8b,Cidec,-0.003946773242205381,0.003946773242205381,0.4755637049674988,0.39632177352905273
+eccrine-placode,Cidec,Pnpla2,-0.0038009807467460632,0.0038009807467460632,0.39632177352905273,0.32516807317733765
+eccrine-placode,Car3,Adig,-0.003687665332108736,0.003687665332108736,0.48335644602775574,0.27328336238861084
+eccrine-placode,Adipoq,Cidea,-0.003670578124001622,0.003670578124001622,0.40856802463531494,0.3739706873893738
+eccrine-placode,Adipoq,Hbb-bs,-0.0036376304924488068,0.0036376304924488068,0.40856802463531494,0.2474367916584015
+eccrine-placode,Cidec,Cidea,-0.003623552853241563,0.003623552853241563,0.39632177352905273,0.3739706873893738
+eccrine-placode,Adipoq,Lpl,-0.0036160354502499104,0.0036160354502499104,0.40856802463531494,0.256544828414917
+eccrine-placode,Car3,Pnpla2,-0.00359762879088521,0.00359762879088521,0.48335644602775574,0.32516807317733765
+eccrine-placode,Adipoq,Gpd1,-0.003516582539305091,0.003516582539305091,0.40856802463531494,0.2570132315158844
+eccrine-placode,Cidec,Lpl,-0.003433171659708023,0.003433171659708023,0.39632177352905273,0.256544828414917
+eccrine-placode,Cidec,Hbb-bs,-0.003419038839638233,0.003419038839638233,0.39632177352905273,0.2474367916584015
+eccrine-placode,Adipoq,Retn,-0.003372214501723647,0.003372214501723647,0.40856802463531494,0.24095529317855835
+eccrine-placode,Cox8b,Cidea,-0.003369808429852128,0.003369808429852128,0.4755637049674988,0.3739706873893738
+eccrine-placode,Cox8b,Pnpla2,-0.0033117039129137993,0.0033117039129137993,0.4755637049674988,0.32516807317733765
+eccrine-placode,Cidec,Gpd1,-0.003305263351649046,0.003305263351649046,0.39632177352905273,0.2570132315158844
+eccrine-placode,Cox8b,Adig,-0.0032959049567580223,0.0032959049567580223,0.4755637049674988,0.27328336238861084
+eccrine-placode,Car3,Hbb-bs,-0.0032867630943655968,0.0032867630943655968,0.48335644602775574,0.2474367916584015
+eccrine-placode,Car3,Cidea,-0.0031922231428325176,0.0031922231428325176,0.48335644602775574,0.3739706873893738
+eccrine-placode,Car3,Gpd1,-0.0031638212967664003,0.0031638212967664003,0.48335644602775574,0.2570132315158844
+eccrine-placode,Cidec,Retn,-0.0031429617665708065,0.0031429617665708065,0.39632177352905273,0.24095529317855835
+eccrine-placode,Adipoq,Ppp1r1a,-0.003101541195064783,0.003101541195064783,0.40856802463531494,0.24090075492858887
+eccrine-placode,Pnpla2,Adig,-0.003101038048043847,0.003101038048043847,0.32516807317733765,0.27328336238861084
+eccrine-secretory,Adipoq,Cidec,-0.0015279967337846756,0.0015279967337846756,0.17898477613925934,0.17002375423908234
+eccrine-secretory,Car3,Adipoq,-0.0013864353531971574,0.0013864353531971574,0.2018413245677948,0.17898477613925934
+eccrine-secretory,Ackr4,Sult5a1,-0.001290700165554881,0.001290700165554881,-0.1311388909816742,-0.12776564061641693
+eccrine-secretory,Car3,Cidec,-0.0012213606387376785,0.0012213606387376785,0.2018413245677948,0.17002375423908234
+eccrine-secretory,Adipoq,Ackr4,0.0012186197564005852,0.0012186197564005852,0.17898477613925934,-0.1311388909816742
+eccrine-secretory,Adipoq,Pnpla2,-0.001126555260270834,0.001126555260270834,0.17898477613925934,0.15163913369178772
+eccrine-secretory,Adipoq,Sult5a1,0.0011189170181751251,0.0011189170181751251,0.17898477613925934,-0.12776564061641693
+eccrine-secretory,Cidec,Ackr4,0.0010936134494841099,0.0010936134494841099,0.17002375423908234,-0.1311388909816742
+eccrine-secretory,Adipoq,Adig,-0.0010746330954134464,0.0010746330954134464,0.17898477613925934,0.136051207780838
+eccrine-secretory,Cidec,Sult5a1,0.001010101637803018,0.001010101637803018,0.17002375423908234,-0.12776564061641693
+eccrine-secretory,Cidec,Pnpla2,-0.0009989042300730944,0.0009989042300730944,0.17002375423908234,0.15163913369178772
+eccrine-secretory,Cox8b,Adipoq,-0.0009988372912630439,0.0009988372912630439,0.19152235984802246,0.17898477613925934
+eccrine-secretory,Fcgbp,Ackr4,-0.00098482018802315,0.00098482018802315,-0.1474011242389679,-0.1311388909816742
+eccrine-secretory,Car3,Ackr4,0.0009782075649127364,0.0009782075649127364,0.2018413245677948,-0.1311388909816742
+eccrine-secretory,Sult5a1,Gm13305,-0.0009609272819943726,0.0009609272819943726,-0.12776564061641693,-0.12248125672340393
+eccrine-secretory,Cidec,Adig,-0.0009571586269885302,0.0009571586269885302,0.17002375423908234,0.136051207780838
+eccrine-secretory,Fcgbp,Sult5a1,-0.0009396054083481431,0.0009396054083481431,-0.1474011242389679,-0.12776564061641693
+eccrine-secretory,Adipoq,Fcgbp,0.0009210787829943001,0.0009210787829943001,0.17898477613925934,-0.1474011242389679
+eccrine-secretory,Car3,Pnpla2,-0.0009191171848215163,0.0009191171848215163,0.2018413245677948,0.15163913369178772
+eccrine-secretory,Ackr4,Gm13305,-0.0009068904910236597,0.0009068904910236597,-0.1311388909816742,-0.12248125672340393
+eccrine-secretory,Ckmt1,Sult5a1,-0.0008986406028270721,0.0008986406028270721,-0.1557808518409729,-0.12776564061641693
+eccrine-secretory,Trp63,Sult5a1,-0.0008968199254013598,0.0008968199254013598,-0.13686686754226685,-0.12776564061641693
+eccrine-secretory,Cox8b,Cidec,-0.0008948945323936641,0.0008948945323936641,0.19152235984802246,0.17002375423908234
+eccrine-secretory,Trp63,Ackr4,-0.0008915325161069632,0.0008915325161069632,-0.13686686754226685,-0.1311388909816742
+eccrine-secretory,Car3,Cox8b,-0.0008757355390116572,0.0008757355390116572,0.2018413245677948,0.19152235984802246
+eccrine-secretory,Car3,Sult5a1,0.0008627162897028029,0.0008627162897028029,0.2018413245677948,-0.12776564061641693
+eccrine-secretory,Pnpla2,Ackr4,0.0008530934574082494,0.0008530934574082494,0.15163913369178772,-0.1311388909816742
+eccrine-secretory,Ckmt1,Ackr4,-0.0008530697086825967,0.0008530697086825967,-0.1557808518409729,-0.1311388909816742
+eccrine-secretory,Car3,Adig,-0.0008369889692403376,0.0008369889692403376,0.2018413245677948,0.136051207780838
+eccrine-secretory,Adipoq,Lpl,-0.0008369844872504473,0.0008369844872504473,0.17898477613925934,0.1306002140045166
+eden-dermal-niche,Htra3,Clec3b,-0.00045718852197751403,0.00045718852197751403,0.0713101178407669,0.06344007700681686
+eden-dermal-niche,Fxyd1,Clec3b,-0.000457011628895998,0.000457011628895998,0.0740082710981369,0.06344007700681686
+eden-dermal-niche,Fxyd1,Htra3,-0.000422669923864305,0.000422669923864305,0.0740082710981369,0.0713101178407669
+eden-dermal-niche,Dpt,Clec3b,-0.0003546674852259457,0.0003546674852259457,0.06626459211111069,0.06344007700681686
+eden-dermal-niche,Fxyd1,Pcolce2,-0.00034056356525979936,0.00034056356525979936,0.0740082710981369,0.06233661621809006
+eden-dermal-niche,Clec3b,Pcolce2,-0.00034048044472001493,0.00034048044472001493,0.06344007700681686,0.06233661621809006
+eden-dermal-niche,Rarres2,Clec3b,-0.0003370731428731233,0.0003370731428731233,0.07337608188390732,0.06344007700681686
+eden-dermal-niche,Htra3,Pcolce2,-0.0003326115838717669,0.0003326115838717669,0.0713101178407669,0.06233661621809006
+eden-dermal-niche,Rarres2,Htra3,-0.00031228482839651406,0.00031228482839651406,0.07337608188390732,0.0713101178407669
+eden-dermal-niche,Cox8b,Lpl,0.00031163933454081416,0.00031163933454081416,0.07272309064865112,0.06448497623205185
+eden-dermal-niche,Fxyd1,Rarres2,-0.000302479398669675,0.000302479398669675,0.0740082710981369,0.07337608188390732
+eden-dermal-niche,Fxyd1,Dpt,-0.0003015293332282454,0.0003015293332282454,0.0740082710981369,0.06626459211111069
+eden-dermal-niche,Cyp2f2,Clec3b,-0.0003002795565407723,0.0003002795565407723,0.07125179469585419,0.06344007700681686
+eden-dermal-niche,Cox8b,Cidec,0.00029406961402855814,0.00029406961402855814,0.07272309064865112,0.06211929768323898
+eden-dermal-niche,Htra3,Dpt,-0.00029073815676383674,0.00029073815676383674,0.0713101178407669,0.06626459211111069
+eden-dermal-niche,Dpt,Pcolce2,-0.0002892831980716437,0.0002892831980716437,0.06626459211111069,0.06233661621809006
+eden-dermal-niche,Fxyd1,Serpina3c,-0.0002873757039196789,0.0002873757039196789,0.0740082710981369,0.06298515200614929
+eden-dermal-niche,Car3,Thy1,0.0002848880540113896,0.0002848880540113896,0.07372520864009857,0.0630541741847992
+eden-dermal-niche,Cox8b,Adipoq,0.0002840689558070153,0.0002840689558070153,0.07272309064865112,0.06512601673603058
+eden-dermal-niche,Clec3b,Serpina3c,-0.0002784586395137012,0.0002784586395137012,0.06344007700681686,0.06298515200614929
+eden-dermal-niche,Car3,Cox8b,0.0002750987478066236,0.0002750987478066236,0.07372520864009857,0.07272309064865112
+eden-dermal-niche,Car3,Lpl,0.000272760255029425,0.000272760255029425,0.07372520864009857,0.06448497623205185
+eden-dermal-niche,Fxyd1,Cyp2f2,-0.0002677628071978688,0.0002677628071978688,0.0740082710981369,0.07125179469585419
+eden-dermal-niche,Lpl,Cidec,0.0002557957486715168,0.0002557957486715168,0.06448497623205185,0.06211929768323898
+eden-dermal-niche,Htra3,Cyp2f2,-0.000254282756941393,0.000254282756941393,0.0713101178407669,0.07125179469585419
+eden-dermal-niche,Htra3,Serpina3c,-0.00025029259268194437,0.00025029259268194437,0.0713101178407669,0.06298515200614929
+eden-dermal-niche,Adipoq,Lpl,0.0002486282028257847,0.0002486282028257847,0.06512601673603058,0.06448497623205185
+eden-dermal-niche,Adamts2,Clec3b,-0.0002482614363543689,0.0002482614363543689,0.06630747020244598,0.06344007700681686
+eden-dermal-niche,Rarres2,Dpt,-0.00024186847440432757,0.00024186847440432757,0.07337608188390732,0.06626459211111069
+eden-dermal-niche,Osr2,Clec3b,-0.00023580319248139858,0.00023580319248139858,0.07916615903377533,0.06344007700681686
+endothelial,Esam,Sdpr,-2.504268559277989e-05,2.504268559277989e-05,0.18619680404663086,0.1501748114824295
+endothelial,Esam,Apold1,-2.4376919100177474e-05,2.4376919100177474e-05,0.18619680404663086,0.1461012065410614
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+endothelial,Tie1,Rasip1,-2.0880881493212655e-05,2.0880881493212655e-05,0.1764821708202362,0.1587253212928772
+endothelial,C1qtnf9,Sdpr,-2.0581504941219464e-05,2.0581504941219464e-05,0.17510326206684113,0.1501748114824295
+endothelial,Icam2,Rasip1,-2.0142826542723924e-05,2.0142826542723924e-05,0.17584192752838135,0.1587253212928772
+endothelial,Cdh5,Rasip1,-1.9718589101103134e-05,1.9718589101103134e-05,0.17696647346019745,0.1587253212928772
+endothelial,C1qtnf9,Apold1,-1.966586205526255e-05,1.966586205526255e-05,0.17510326206684113,0.1461012065410614
+endothelial,Aplnr,Apold1,-1.9059505575569347e-05,1.9059505575569347e-05,0.17748090624809265,0.1461012065410614
+endothelial,Aplnr,Sdpr,-1.813342714740429e-05,1.813342714740429e-05,0.17748090624809265,0.1501748114824295
+endothelial,Adgrf5,Apold1,-1.801050348149147e-05,1.801050348149147e-05,0.1480112373828888,0.1461012065410614
+endothelial,Gpihbp1,Apold1,-1.729031282593496e-05,1.729031282593496e-05,0.19264714419841766,0.1461012065410614
+endothelial,Aplnr,Tmem255a,1.5757193978060968e-05,1.5757193978060968e-05,0.17748090624809265,0.1519910842180252
+endothelial,Tinagl1,Sdpr,-1.5299061487894505e-05,1.5299061487894505e-05,0.16430631279945374,0.1501748114824295
+endothelial,Grrp1,Rasip1,-1.5190482372418046e-05,1.5190482372418046e-05,0.1710452437400818,0.1587253212928772
+endothelial,Emcn,Apold1,-1.496201366535388e-05,1.496201366535388e-05,0.14616966247558594,0.1461012065410614
+endothelial,Gimap6,Sdpr,-1.4841099073237274e-05,1.4841099073237274e-05,0.1596517562866211,0.1501748114824295
+endothelial,Sdpr,Adgrf5,-1.4392239791050088e-05,1.4392239791050088e-05,0.1501748114824295,0.1480112373828888
+endothelial,Tinagl1,Apold1,-1.3786217095912434e-05,1.3786217095912434e-05,0.16430631279945374,0.1461012065410614
+endothelial,Kdr,Rasip1,-1.3243232388049364e-05,1.3243232388049364e-05,0.16225993633270264,0.1587253212928772
+endothelial,Grrp1,Apold1,-1.323281685472466e-05,1.323281685472466e-05,0.1710452437400818,0.1461012065410614
+endothelial,Esam,Tmem255a,1.3090341781207826e-05,1.3090341781207826e-05,0.18619680404663086,0.1519910842180252
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+immune,Gata3,Osr2,0.0009969314560294151,0.0009969314560294151,-0.06238430738449097,0.06065120920538902
+immune,Fam25c,Osr2,0.0009088398655876517,0.0009088398655876517,-0.07752911001443863,0.06065120920538902
+immune,Alox12e,Osr2,0.0008840055670589209,0.0008840055670589209,-0.062092483043670654,0.06065120920538902
+immune,Anxa8,Osr2,0.0008780767675489187,0.0008780767675489187,-0.0727551281452179,0.06065120920538902
+immune,Gata3,Alox12e,-0.0008312178542837501,0.0008312178542837501,-0.06238430738449097,-0.062092483043670654
+immune,Anxa8,Gata3,-0.0008197161369025707,0.0008197161369025707,-0.0727551281452179,-0.06238430738449097
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+immune,Rarres2,Osr2,0.0007721130969002843,0.0007721130969002843,0.06425803899765015,0.06065120920538902
+immune,Fam25c,Alox12e,-0.0007460564374923706,0.0007460564374923706,-0.07752911001443863,-0.062092483043670654
+immune,Fam25c,Anxa8,-0.000733808265067637,0.000733808265067637,-0.07752911001443863,-0.0727551281452179
+immune,Anxa8,Alox12e,-0.0007251119241118431,0.0007251119241118431,-0.0727551281452179,-0.062092483043670654
+immune,Osr2,Calm4,0.000721465446986258,0.000721465446986258,0.06065120920538902,-0.06030673533678055
+immune,Dsg1a,Osr2,0.0006881989538669586,0.0006881989538669586,-0.07002934068441391,0.06065120920538902
+immune,Htra3,Osr2,0.000670448993332684,0.000670448993332684,0.06314762681722641,0.06065120920538902
+immune,Calm5,Osr2,0.0006545595242641866,0.0006545595242641866,-0.06596989184617996,0.06065120920538902
+immune,Gata3,Calm4,-0.000645765452645719,0.000645765452645719,-0.06238430738449097,-0.06030673533678055
+immune,Calm5,Alox12e,-0.000634421652648598,0.000634421652648598,-0.06596989184617996,-0.062092483043670654
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+immune,Dsg1a,Gata3,-0.0006125688087195158,0.0006125688087195158,-0.07002934068441391,-0.06238430738449097
+immune,Rarres2,Gata3,-0.0006070530507713556,0.0006070530507713556,0.06425803899765015,-0.06238430738449097
+immune,Fam25c,Calm4,-0.0006069107912480831,0.0006069107912480831,-0.07752911001443863,-0.06030673533678055
+immune,H2-DMb2,Osr2,-0.0005970349302515388,0.0005970349302515388,0.06247230991721153,0.06065120920538902
+immune,Anxa8,Calm4,-0.0005959788104519248,0.0005959788104519248,-0.0727551281452179,-0.06030673533678055
+immune,Anxa8,Rarres2,-0.0005893745692446828,0.0005893745692446828,-0.0727551281452179,0.06425803899765015
+immune,Anxa8,Dsg1a,-0.0005845155101269484,0.0005845155101269484,-0.0727551281452179,-0.07002934068441391
+immune,Fam25c,Dsg1a,-0.0005790083087049425,0.0005790083087049425,-0.07752911001443863,-0.07002934068441391
+immune,Fam25c,Htra3,-0.0005676115397363901,0.0005676115397363901,-0.07752911001443863,0.06314762681722641
+immune,Calm5,Gata3,-0.0005610365187749267,0.0005610365187749267,-0.06596989184617996,-0.06238430738449097
+immune,Fam25c,Calm5,-0.0005592427914962173,0.0005592427914962173,-0.07752911001443863,-0.06596989184617996
+immune,Rarres2,Alox12e,-0.0005549724446609616,0.0005549724446609616,0.06425803899765015,-0.062092483043670654
+melanocyte,Pax3,Sox10,8.121939572447445e-06,8.121939572447445e-06,0.13281792402267456,0.08396803587675095
+melanocyte,Reln,Akr1c18,-7.16138356438023e-06,7.16138356438023e-06,-0.08940119296312332,0.0817781314253807
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+melanocyte,Mgll,Akr1c18,-7.145980816858355e-06,7.145980816858355e-06,0.08536499738693237,0.0817781314253807
+melanocyte,Npy,Pax3,6.749761269020382e-06,6.749761269020382e-06,0.1435016393661499,0.13281792402267456
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+sebaceous,Defb6,Cma1,6.731781923008384e-06,6.731781923008384e-06,0.5888569355010986,-0.4480721354484558
+sebaceous,Gpx3,Notum,-6.651891453657299e-06,6.651891453657299e-06,-0.5130580067634583,-0.4690847098827362
+sebaceous,Adipoq,H2-DMb2,6.637100796069717e-06,6.637100796069717e-06,-0.5521821975708008,0.4392959773540497
+sebaceous,Cox8b,Cma1,-6.549547833856195e-06,6.549547833856195e-06,-0.7046936750411987,-0.4480721354484558
+sebaceous,Cidea,Cma1,-6.514619599329308e-06,6.514619599329308e-06,-0.5273117423057556,-0.4480721354484558
+sebaceous,Cox8b,Notum,-6.400411166396225e-06,6.400411166396225e-06,-0.7046936750411987,-0.4690847098827362
+sebaceous,Cidec,H2-DMb2,6.393513103830628e-06,6.393513103830628e-06,-0.5427451133728027,0.4392959773540497
+sebaceous,Gpx3,Hba-a1,6.382687388395425e-06,6.382687388395425e-06,-0.5130580067634583,-0.47014912962913513
+spinous,Trp63,Fcgbp,-0.001262822188436985,0.001262822188436985,-0.16756370663642883,-0.14844611287117004
+spinous,Calm5,Clca3a2,0.0010884543880820274,0.0010884543880820274,-0.2120736837387085,-0.1570589244365692
+spinous,Oas1f,Clca3a2,0.0009829794289544225,0.0009829794289544225,-0.18096141517162323,-0.1570589244365692
+spinous,Clca3a2,Gdpd2,0.0009610028355382383,0.0009610028355382383,-0.1570589244365692,-0.15302419662475586
+spinous,Clca3a2,Cfap57,0.0008826656267046928,0.0008826656267046928,-0.1570589244365692,-0.1563771516084671
+spinous,Anxa8,Trp63,-0.0008296752348542213,0.0008296752348542213,-0.18820498883724213,-0.16756370663642883
+spinous,Trp63,Clca3a2,-0.0008154066745191813,0.0008154066745191813,-0.16756370663642883,-0.1570589244365692
+spinous,Calm5,Gdpd2,-0.0007727260235697031,0.0007727260235697031,-0.2120736837387085,-0.15302419662475586
+spinous,Anxa8,Fcgbp,-0.0007557073840871453,0.0007557073840871453,-0.18820498883724213,-0.14844611287117004
+spinous,Fcgbp,Dsg1a,-0.0006945023196749389,0.0006945023196749389,-0.14844611287117004,-0.1436401754617691
+spinous,Calm5,Urah,0.0006715112249366939,0.0006715112249366939,-0.2120736837387085,-0.17681442201137543
+spinous,Trp63,Wnt10a,-0.0006677189376205206,0.0006677189376205206,-0.16756370663642883,-0.14016452431678772
+spinous,Oas1f,Urah,0.0006443229503929615,0.0006443229503929615,-0.18096141517162323,-0.17681442201137543
+spinous,Trp63,Gata3,-0.0006246572593227029,0.0006246572593227029,-0.16756370663642883,-0.16534359753131866
+spinous,Cfap57,Fcgbp,0.00058534782147035,0.00058534782147035,-0.1563771516084671,-0.14844611287117004
+spinous,Gata3,Fcgbp,-0.0005508641479536891,0.0005508641479536891,-0.16534359753131866,-0.14844611287117004
+spinous,Ckmt1,Oas1f,0.0005441023386083543,0.0005441023386083543,-0.18630436062812805,-0.18096141517162323
+spinous,Trp63,Gdpd2,0.0005361260264180601,0.0005361260264180601,-0.16756370663642883,-0.15302419662475586
+spinous,Gdpd2,Fcgbp,0.0005152465309947729,0.0005152465309947729,-0.15302419662475586,-0.14844611287117004
+spinous,Trp63,Dsg1a,-0.0005071049090474844,0.0005071049090474844,-0.16756370663642883,-0.1436401754617691
+spinous,Oas1f,Fcgbp,0.0004727804334834218,0.0004727804334834218,-0.18096141517162323,-0.14844611287117004
+spinous,Clca3a2,Fcgbp,-0.00047176386578939855,0.00047176386578939855,-0.1570589244365692,-0.14844611287117004
+spinous,Capns2,Cfap57,0.00047145207645371556,0.00047145207645371556,-0.1674073338508606,-0.1563771516084671
+spinous,Anxa8,Cfap57,0.0004651880881283432,0.0004651880881283432,-0.18820498883724213,-0.1563771516084671
+spinous,Oas1f,Capns2,0.0004640432307496667,0.0004640432307496667,-0.18096141517162323,-0.1674073338508606
+spinous,Calm5,Calm4,0.00046108750393614173,0.00046108750393614173,-0.2120736837387085,-0.13643845915794373
+spinous,Fam25c,Oas1f,0.0004542551178019494,0.0004542551178019494,-0.19421039521694183,-0.18096141517162323
+spinous,Oas1f,Cfap57,0.0004507839912548661,0.0004507839912548661,-0.18096141517162323,-0.1563771516084671
+spinous,Anxa8,Gdpd2,0.00045055014197714627,0.00045055014197714627,-0.18820498883724213,-0.15302419662475586
+spinous,Fam25c,Cfap57,0.00044639408588409424,0.00044639408588409424,-0.19421039521694183,-0.1563771516084671
+unassigned,Adipoq,Cidec,-0.0009173503494821489,0.0009173503494821489,-0.19697649776935577,-0.19669437408447266
+unassigned,Car3,Adipoq,-0.0009096998837776482,0.0009096998837776482,-0.27928340435028076,-0.19697649776935577
+unassigned,Cox8b,Car3,-0.0007674322696402669,0.0007674322696402669,-0.2926693260669708,-0.27928340435028076
+unassigned,Car3,Cidec,-0.0007541942759416997,0.0007541942759416997,-0.27928340435028076,-0.19669437408447266
+unassigned,Cox8b,Smpx,-0.0007341188611462712,0.0007341188611462712,-0.2926693260669708,-0.15543867647647858
+unassigned,Myl1,Pgam2,-0.000690727902110666,0.000690727902110666,-0.20416253805160522,-0.1658681333065033
+unassigned,Cox8b,Myl1,-0.0006798911490477622,0.0006798911490477622,-0.2926693260669708,-0.20416253805160522
+unassigned,Cox8b,Adipoq,-0.0006635846802964807,0.0006635846802964807,-0.2926693260669708,-0.19697649776935577
+unassigned,Myl1,Tnnt3,-0.0006583117647096515,0.0006583117647096515,-0.20416253805160522,-0.16702409088611603
+unassigned,Cox8b,Pgam2,-0.0006582654314115644,0.0006582654314115644,-0.2926693260669708,-0.1658681333065033
+unassigned,Myl1,Mylpf,-0.0006568628596141934,0.0006568628596141934,-0.20416253805160522,-0.16260778903961182
+unassigned,Myl1,Smpx,-0.0006536280852742493,0.0006536280852742493,-0.20416253805160522,-0.15543867647647858
+unassigned,Myl1,Ckm,-0.0006473571411333978,0.0006473571411333978,-0.20416253805160522,-0.1756850928068161
+unassigned,Car3,Myl1,-0.0006471029482781887,0.0006471029482781887,-0.27928340435028076,-0.20416253805160522
+unassigned,Myl1,Tcap,-0.000642740516923368,0.000642740516923368,-0.20416253805160522,-0.1562281847000122
+unassigned,Cox8b,Ckm,-0.000633622519671917,0.000633622519671917,-0.2926693260669708,-0.1756850928068161
+unassigned,Cox8b,Tnnt3,-0.0006308938609436154,0.0006308938609436154,-0.2926693260669708,-0.16702409088611603
+unassigned,Cox8b,Tcap,-0.0006298209191299975,0.0006298209191299975,-0.2926693260669708,-0.1562281847000122
+unassigned,Car3,Pgam2,-0.0006297421641647816,0.0006297421641647816,-0.27928340435028076,-0.1658681333065033
+unassigned,Myl1,Tnnc2,-0.0006199916824698448,0.0006199916824698448,-0.20416253805160522,-0.185897558927536
+unassigned,Acta1,Myl1,-0.0006198547780513763,0.0006198547780513763,-0.2210167646408081,-0.20416253805160522
+unassigned,Car3,Smpx,-0.0006188148399814963,0.0006188148399814963,-0.27928340435028076,-0.15543867647647858
+unassigned,Pgam2,Mylpf,-0.0006022371235303581,0.0006022371235303581,-0.1658681333065033,-0.16260778903961182
+unassigned,Car3,Tcap,-0.0005969495978206396,0.0005969495978206396,-0.27928340435028076,-0.1562281847000122
+unassigned,Myl1,Cox6a2,-0.0005937251844443381,0.0005937251844443381,-0.20416253805160522,-0.1579563468694687
+unassigned,Pgam2,Smpx,-0.0005858978838659823,0.0005858978838659823,-0.1658681333065033,-0.15543867647647858
+unassigned,Tnnt3,Pgam2,-0.0005849737208336592,0.0005849737208336592,-0.16702409088611603,-0.1658681333065033
+unassigned,Myl1,Atp2a1,-0.0005834048497490585,0.0005834048497490585,-0.20416253805160522,-0.16057823598384857
+unassigned,Car3,Tnnt3,-0.0005821818485856056,0.0005821818485856056,-0.27928340435028076,-0.16702409088611603
+unassigned,Lhx2,Cidea,-0.0005800154758617282,0.0005800154758617282,0.18940499424934387,-0.17747139930725098

discovery/85_pan_skin_hessian_top20_genes.json

@@ -0,0 +1,530 @@
+{
+  "HF-DP": [
+    "Itih5",
+    "Bmp4",
+    "Dkk2",
+    "Vstm4",
+    "P4ha2",
+    "Sfrp5",
+    "Ltbp1",
+    "Atp1a2",
+    "Actc1",
+    "Cdh15",
+    "Cyp2f2",
+    "Egfl6",
+    "Edn3",
+    "Gfra2",
+    "Fam180a",
+    "Cilp",
+    "Il1r2",
+    "Grem2",
+    "Serpina3c",
+    "Penk"
+  ],
+  "HF-ORS": [
+    "Cd68",
+    "Spi1",
+    "Lilrb4a",
+    "Fcer1g",
+    "Tyrobp",
+    "Alox5ap",
+    "Ly6g6e",
+    "Ctss",
+    "Plek",
+    "AI607873",
+    "H2-Aa",
+    "Csf2rb",
+    "H2-Eb1",
+    "Cd86",
+    "Csf1r",
+    "Cfp",
+    "H2-Ab1",
+    "Ms4a6c",
+    "Lilr4b",
+    "Ccl9"
+  ],
+  "HF-placode": [
+    "Lmo1",
+    "Lhx2",
+    "Bcam",
+    "Trp63",
+    "Atp6v1b1",
+    "Fermt1",
+    "Pdgfa",
+    "Lamc2",
+    "Igsf9",
+    "Wnt10a",
+    "Lgr6",
+    "Urah",
+    "Golga7b",
+    "Sostdc1",
+    "Ajuba",
+    "Wnt6",
+    "Ptch2",
+    "Dlk2",
+    "Ckmt1",
+    "Cbr2"
+  ],
+  "UNK": [
+    "Hmha1",
+    "Rac2",
+    "Laptm5",
+    "Coro1a",
+    "Cd52",
+    "Cd53",
+    "Ptpn18",
+    "AI662270",
+    "Hcls1",
+    "Ptprcap",
+    "Fcer1g",
+    "Nkg7",
+    "Ctsw",
+    "Selplg",
+    "Fxyd5",
+    "Cd3g",
+    "Il2rg",
+    "Lcp1",
+    "Bin2",
+    "Gmfg"
+  ],
+  "basal-IFE": [
+    "Serpina3n",
+    "Htra1",
+    "Lmo1",
+    "Gas6",
+    "Mt2",
+    "Cox8b",
+    "Ly6a",
+    "Clec3b",
+    "Ly6c1",
+    "Pcolce2",
+    "Bcam",
+    "Ccl11",
+    "Rnase4",
+    "Car3",
+    "Trp63",
+    "Rarres2",
+    "Nnat",
+    "Scara5",
+    "Htra3",
+    "Actc1"
+  ],
+  "basal-multipotent": [
+    "Anxa8",
+    "Fam25c",
+    "Urah",
+    "Ckmt1",
+    "Capns2",
+    "Trp63",
+    "Dsg1a",
+    "Calm5",
+    "Clca3a2",
+    "Alox12e",
+    "Calm4",
+    "Gpx3",
+    "Gata3",
+    "Defb6",
+    "Pkib",
+    "Oas1f",
+    "Susd2",
+    "Fcgbp",
+    "Pf4",
+    "Plbd1"
+  ],
+  "dermal-condensate": [
+    "Car3",
+    "Cox8b",
+    "Adipoq",
+    "Cidec",
+    "Cidea",
+    "Pnpla2",
+    "Chchd10",
+    "Lpl",
+    "Adig",
+    "Gpd1",
+    "Ppp1r1a",
+    "Agt",
+    "Retn",
+    "Cma1",
+    "Tpsb2",
+    "mt-Atp6",
+    "8430408G22Rik",
+    "Ctsh",
+    "Acta1",
+    "Mrap"
+  ],
+  "eccrine-duct": [
+    "Cldn6",
+    "Ppp2r2b",
+    "Upk1b",
+    "Gm266",
+    "Smtnl2",
+    "Crabp1",
+    "Reep6",
+    "Upk1a",
+    "Cldn8",
+    "Cldn23",
+    "Skint9",
+    "Wnt5a",
+    "Dkk2",
+    "Tmem132c",
+    "Nrp1",
+    "Cldn3",
+    "Cox4i2",
+    "Alox12e",
+    "Slc2a3",
+    "Limch1"
+  ],
+  "eccrine-ductal": [
+    "Car3",
+    "Cox8b",
+    "Cyba",
+    "C1qa",
+    "Ctsz",
+    "Serpina3n",
+    "C1qc",
+    "Myl1",
+    "Csf1r",
+    "Ccl11",
+    "Hexa",
+    "Ccl8",
+    "C1qb",
+    "Adipoq",
+    "Pcolce2",
+    "Acta1",
+    "Ms4a7",
+    "Ctsh",
+    "Tmem106a",
+    "Pf4"
+  ],
+  "eccrine-placode": [
+    "Car3",
+    "Cox8b",
+    "Adipoq",
+    "Cidec",
+    "Cidea",
+    "Pnpla2",
+    "Chchd10",
+    "Tgfbi",
+    "mt-Atp6",
+    "Adig",
+    "Ctsh",
+    "Acta1",
+    "Myl1",
+    "Cma1",
+    "Gpd1",
+    "Lpl",
+    "Hbb-bs",
+    "Il11ra1",
+    "Retn",
+    "Ppp1r1a"
+  ],
+  "eccrine-secretory": [
+    "Car3",
+    "Cox8b",
+    "Adipoq",
+    "Cidec",
+    "Cidea",
+    "Tgfbi",
+    "Ckmt1",
+    "Pnpla2",
+    "Fcgbp",
+    "Urah",
+    "Anxa8",
+    "Trp63",
+    "Adig",
+    "Ackr4",
+    "Lpl",
+    "Chchd10",
+    "Sult5a1",
+    "Clca3a2",
+    "Gm13305",
+    "Capns2"
+  ],
+  "eden-dermal-niche": [
+    "Cpz",
+    "Osr2",
+    "Fxyd1",
+    "Car3",
+    "Rarres2",
+    "Cox8b",
+    "Htra3",
+    "Cyp2f2",
+    "Adamts2",
+    "Dpt",
+    "Adipoq",
+    "Lpl",
+    "Hmga2",
+    "Clec3b",
+    "Nnat",
+    "Thy1",
+    "Serpina3c",
+    "Pcolce2",
+    "Cidec",
+    "Mmp23"
+  ],
+  "endothelial": [
+    "Gpihbp1",
+    "Esam",
+    "Aplnr",
+    "Cdh5",
+    "Tie1",
+    "Icam2",
+    "C1qtnf9",
+    "Grrp1",
+    "Robo4",
+    "Tinagl1",
+    "Kdr",
+    "Gimap6",
+    "Rasip1",
+    "Arhgef15",
+    "Tmem255a",
+    "Sdpr",
+    "C130074G19Rik",
+    "Adgrf5",
+    "Emcn",
+    "Apold1"
+  ],
+  "fibroblast": [
+    "Adipoq",
+    "Cidec",
+    "Lhx2",
+    "Car3",
+    "Cox8b",
+    "Lpl",
+    "Cidea",
+    "Pnpla2",
+    "Adig",
+    "Alcam",
+    "Trp63",
+    "Bcam",
+    "Lmo1",
+    "Ptn",
+    "Chchd10",
+    "Agt",
+    "Gpx3",
+    "Gpd1",
+    "Ppp1r1a",
+    "Smoc2"
+  ],
+  "fibroblast-papillary": [
+    "Hba-a1",
+    "Hba-a2",
+    "Igf2",
+    "Hbb-bt",
+    "Hbb-bs",
+    "Nnat",
+    "Mest",
+    "Agtr2",
+    "Akr1c18",
+    "Rarres2",
+    "Krt79",
+    "Prlr",
+    "Cma1",
+    "Fxyd1",
+    "Serpina3n",
+    "Cpa3",
+    "S100a1",
+    "Cdkn2c",
+    "Gstm1",
+    "6330403K07Rik"
+  ],
+  "fibroblast-reticular": [
+    "Mest",
+    "Dlk1",
+    "Igf2",
+    "Maged2",
+    "Peg3",
+    "Twist2",
+    "Osr1",
+    "Crabp1",
+    "Cdkn1c",
+    "Ndn",
+    "Agtr2",
+    "Col26a1",
+    "Pth1r",
+    "Nrp1",
+    "H19",
+    "Gpx7",
+    "Efemp2",
+    "Mdk",
+    "Gpc3",
+    "Fbn2"
+  ],
+  "granular": [
+    "Fcgbp",
+    "Htra3",
+    "Serpina3n",
+    "Cd302",
+    "Cd34",
+    "Olfml3",
+    "Selm",
+    "Slco2a1",
+    "Col5a2",
+    "Mfap2",
+    "Cyp26b1",
+    "Rarres2",
+    "Ccl11",
+    "Aebp1",
+    "Rcn3",
+    "Dpep1",
+    "Tnfrsf18",
+    "Dclk1",
+    "Timp2",
+    "Serping1"
+  ],
+  "hair-placode": [
+    "Cox8b",
+    "Car3",
+    "Adipoq",
+    "Cidec",
+    "Cidea",
+    "Chchd10",
+    "Pnpla2",
+    "Cma1",
+    "Tgfbi",
+    "mt-Atp6",
+    "Lpl",
+    "Tpsb2",
+    "Adig",
+    "Il11ra1",
+    "Acta1",
+    "Ctsh",
+    "Gpd1",
+    "Cd34",
+    "Myl1",
+    "8430408G22Rik"
+  ],
+  "immune": [
+    "Fam25c",
+    "Fcgrt",
+    "Anxa8",
+    "Dsg1a",
+    "Rcn3",
+    "Cd34",
+    "Calm5",
+    "Pcolce",
+    "Rarres2",
+    "Htra3",
+    "H2-DMb2",
+    "Gata3",
+    "Alox12e",
+    "Dpep1",
+    "Cpz",
+    "Plpp3",
+    "Fxyd1",
+    "Osr2",
+    "Bgn",
+    "Calm4"
+  ],
+  "melanocyte": [
+    "Mcoln3",
+    "Npy",
+    "Tyr",
+    "Pax3",
+    "Slc45a2",
+    "Glrb",
+    "Syngr1",
+    "Trpm1",
+    "Syt4",
+    "Mitf",
+    "Kit",
+    "Gucy1b3",
+    "Gsta1",
+    "Slc26a7",
+    "Reln",
+    "Mgll",
+    "Sox10",
+    "Akr1c18",
+    "Cpne4",
+    "Synpr"
+  ],
+  "nascent-eccrine-gland": [
+    "Car3",
+    "Cox8b",
+    "Adipoq",
+    "Cidec",
+    "Cidea",
+    "Chchd10",
+    "Pnpla2",
+    "Myl1",
+    "Acta1",
+    "Ctsh",
+    "Tgfbi",
+    "Adig",
+    "mt-Atp6",
+    "Gpd1",
+    "Il11ra1",
+    "Tnnc2",
+    "Rnase4",
+    "Lgals9",
+    "Pgam2",
+    "Ifi204"
+  ],
+  "sebaceous": [
+    "Cox8b",
+    "Car3",
+    "Defb6",
+    "Adipoq",
+    "Krt79",
+    "Cidec",
+    "Hbb-bs",
+    "Cidea",
+    "Gpx3",
+    "H2-M2",
+    "Hba-a1",
+    "Notum",
+    "Cpne5",
+    "Chchd10",
+    "Cd207",
+    "Cma1",
+    "mt-Atp6",
+    "H2-DMb2",
+    "Dapk2",
+    "Cd72"
+  ],
+  "spinous": [
+    "Calm5",
+    "Fam25c",
+    "Anxa8",
+    "Ckmt1",
+    "Oas1f",
+    "Urah",
+    "Trp63",
+    "Capns2",
+    "Gata3",
+    "Clca3a2",
+    "Cfap57",
+    "Gdpd2",
+    "Fcgbp",
+    "Dsg1a",
+    "Bcam",
+    "Wnt10a",
+    "Hs3st6",
+    "Calm4",
+    "Plek2",
+    "Cbs"
+  ],
+  "unassigned": [
+    "Cox8b",
+    "Car3",
+    "Acta1",
+    "Myl1",
+    "Adipoq",
+    "Cidec",
+    "Lhx2",
+    "Tnnc2",
+    "Cidea",
+    "Ckm",
+    "Chchd10",
+    "Tnnt3",
+    "Pgam2",
+    "Tnni2",
+    "Mylpf",
+    "Atp2a1",
+    "mt-Atp6",
+    "Cox6a2",
+    "Tcap",
+    "Smpx"
+  ]
+}

discovery/85_pancreas_hessian_pairs.csv

@@ -0,0 +1,481 @@
+class,gene_a,gene_b,hessian_off_diag,abs_h,attribution_a,attribution_b
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+mesenchymal,Sfrp1,Vtn,0.00023843599774409086,0.00023843599774409086,-0.5114133358001709,0.4326706528663635
+mesenchymal,Vtn,Hist1h2ap,0.00023797251924406737,0.00023797251924406737,0.4326706528663635,0.37779533863067627
+mesenchymal,Hmga1,Gap43,-0.00022649654420092702,0.00022649654420092702,0.4387035667896271,-0.38698792457580566
+mesenchymal,Tgfbi,Hist1h2ap,-0.00022568696294911206,0.00022568696294911206,-0.434212327003479,0.37779533863067627
+other,Akr1c19,Ube2s,0.00013897602912038565,0.00013897602912038565,-0.8856308460235596,-0.8798946738243103
+other,Ube2i,Ube2s,0.00013135910558048636,0.00013135910558048636,-0.8959742784500122,-0.8798946738243103
+other,Ube2i,Akr1c19,0.00013129613944329321,0.00013129613944329321,-0.8959742784500122,-0.8856308460235596
+other,Aldh1b1,Akr1c19,-0.00013028286048211157,0.00013028286048211157,-0.9049650430679321,-0.8856308460235596
+other,Aldh1b1,Ube2s,-0.00011013790935976431,0.00011013790935976431,-0.9049650430679321,-0.8798946738243103
+other,Ube2s,Ambp,-9.930086525855586e-05,9.930086525855586e-05,-0.8798946738243103,-0.8613907098770142
+other,Aldh1b1,Ube2i,-9.043233876582235e-05,9.043233876582235e-05,-0.9049650430679321,-0.8959742784500122
+other,Ctrb1,Ambp,-8.936270023696125e-05,8.936270023696125e-05,-1.0199841260910034,-0.8613907098770142
+other,Ube2i,Ambp,-7.811366958776489e-05,7.811366958776489e-05,-0.8959742784500122,-0.8613907098770142
+other,Akr1c19,Ambp,-7.782259490340948e-05,7.782259490340948e-05,-0.8856308460235596,-0.8613907098770142
+other,Ctrb1,Cldn6,-7.726383046247065e-05,7.726383046247065e-05,-1.0199841260910034,-0.8729454874992371
+other,Ambp,Spink1,-6.570094410562888e-05,6.570094410562888e-05,-0.8613907098770142,-0.8588333129882812
+other,Cldn6,Spink1,-6.333520286716521e-05,6.333520286716521e-05,-0.8729454874992371,-0.8588333129882812
+other,Akr1c19,Cpa2,-5.899588359170593e-05,5.899588359170593e-05,-0.8856308460235596,-0.8625900745391846
+other,Ube2s,Cpa2,-5.806719491374679e-05,5.806719491374679e-05,-0.8798946738243103,-0.8625900745391846
+other,Ambp,Pnliprp1,-5.8057430578628555e-05,5.8057430578628555e-05,-0.8613907098770142,-0.8587838411331177
+other,Tcf21,Cpa2,5.2455932745942846e-05,5.2455932745942846e-05,0.9703865051269531,-0.8625900745391846
+other,Ctrb1,Tcf21,5.119327033753507e-05,5.119327033753507e-05,-1.0199841260910034,0.9703865051269531
+other,Ctrb1,Sparcl1,-5.108609184389934e-05,5.108609184389934e-05,-1.0199841260910034,0.8634470701217651
+other,Cldn6,Pnliprp1,-5.0753602408804e-05,5.0753602408804e-05,-0.8729454874992371,-0.8587838411331177
+other,Ctrb1,Nudt19,4.994953269488178e-05,4.994953269488178e-05,-1.0199841260910034,-0.8899592161178589
+other,Clps,Ambp,-4.718315176432952e-05,4.718315176432952e-05,-0.9042214155197144,-0.8613907098770142
+other,Nudt19,Akr1c19,4.6838424168527126e-05,4.6838424168527126e-05,-0.8899592161178589,-0.8856308460235596
+other,Tcf21,Cldn6,4.6752913476666436e-05,4.6752913476666436e-05,0.9703865051269531,-0.8729454874992371
+other,Ube2s,Cldn6,-4.63669712189585e-05,4.63669712189585e-05,-0.8798946738243103,-0.8729454874992371
+other,Sparcl1,Spink1,-4.610886026057415e-05,4.610886026057415e-05,0.8634470701217651,-0.8588333129882812
+other,Ctrb1,Wfdc2,-4.55914851045236e-05,4.55914851045236e-05,-1.0199841260910034,-0.8598986864089966
+other,Ctrb1,Cpa2,-4.502044612308964e-05,4.502044612308964e-05,-1.0199841260910034,-0.8625900745391846
+other,Clps,Cldn6,-4.4878139306092635e-05,4.4878139306092635e-05,-0.9042214155197144,-0.8729454874992371
+other,Clps,Sparcl1,-4.4874635932501405e-05,4.4874635932501405e-05,-0.9042214155197144,0.8634470701217651
+unassigned,Prss1,Try10,-0.06893621385097504,0.06893621385097504,-0.7508388757705688,-0.7149887084960938
+unassigned,Prss1,Kctd14,-0.06337346136569977,0.06337346136569977,-0.7508388757705688,-0.6892501711845398
+unassigned,Try10,Kctd14,-0.06308846175670624,0.06308846175670624,-0.7149887084960938,-0.6892501711845398
+unassigned,Ung,Kctd14,0.04362648352980614,0.04362648352980614,0.7392354011535645,-0.6892501711845398
+unassigned,Gpx2,Kctd14,-0.04143723100423813,0.04143723100423813,-0.8388899564743042,-0.6892501711845398
+unassigned,Ung,Try10,0.03646126389503479,0.03646126389503479,0.7392354011535645,-0.7149887084960938
+unassigned,Prss1,Ung,0.03490100055932999,0.03490100055932999,-0.7508388757705688,0.7392354011535645
+unassigned,Gpx2,Try10,-0.03228385001420975,0.03228385001420975,-0.8388899564743042,-0.7149887084960938
+unassigned,Grin3a,Prss1,-0.030184194445610046,0.030184194445610046,-0.769739031791687,-0.7508388757705688
+unassigned,Grin3a,Kctd14,-0.02937733754515648,0.02937733754515648,-0.769739031791687,-0.6892501711845398
+unassigned,Grin3a,Try10,-0.028663158416748047,0.028663158416748047,-0.769739031791687,-0.7149887084960938
+unassigned,Gpx2,Prss1,-0.028597291558980942,0.028597291558980942,-0.8388899564743042,-0.7508388757705688
+unassigned,Prss1,Chst2,-0.028495749458670616,0.028495749458670616,-0.7508388757705688,0.7501049637794495
+unassigned,Col9a3,Kctd14,-0.028078030794858932,0.028078030794858932,-0.8919397592544556,-0.6892501711845398
+unassigned,Gpx2,Ung,0.027717657387256622,0.027717657387256622,-0.8388899564743042,0.7392354011535645
+unassigned,Igfbp4,Kctd14,0.025714067742228508,0.025714067742228508,0.7602500915527344,-0.6892501711845398
+unassigned,Col9a3,Prss1,-0.024645794183015823,0.024645794183015823,-0.8919397592544556,-0.7508388757705688
+unassigned,Neurog3,Kctd14,0.024589071050286293,0.024589071050286293,-0.727164626121521,-0.6892501711845398
+unassigned,Tinagl1,Mest,-0.024578891694545746,0.024578891694545746,-1.0398643016815186,0.904580295085907
+unassigned,Mest,Kctd14,0.02427000179886818,0.02427000179886818,0.904580295085907,-0.6892501711845398
+unassigned,Mest,Gpx2,0.023975947871804237,0.023975947871804237,0.904580295085907,-0.8388899564743042
+unassigned,Col9a3,Try10,-0.023342164233326912,0.023342164233326912,-0.8919397592544556,-0.7149887084960938
+unassigned,Ppp1r1b,Prss1,-0.023169156163930893,0.023169156163930893,-0.7739700078964233,-0.7508388757705688
+unassigned,Ppp1r1b,Chst2,-0.023168504238128662,0.023168504238128662,-0.7739700078964233,0.7501049637794495
+unassigned,Lurap1l,Kctd14,0.022984381765127182,0.022984381765127182,-0.7148849964141846,-0.6892501711845398
+unassigned,Chst2,Try10,-0.022502250969409943,0.022502250969409943,0.7501049637794495,-0.7149887084960938
+unassigned,Mest,Lurap1l,-0.022064045071601868,0.022064045071601868,0.904580295085907,-0.7148849964141846
+unassigned,Mest,Ppp1r1b,-0.021709108725190163,0.021709108725190163,0.904580295085907,-0.7739700078964233
+unassigned,Ung,Lurap1l,-0.021612178534269333,0.021612178534269333,0.7392354011535645,-0.7148849964141846
+unassigned,Gpx2,Grin3a,-0.02095170132815838,0.02095170132815838,-0.8388899564743042,-0.769739031791687

discovery/85_pancreas_hessian_top20_genes.json

@@ -0,0 +1,354 @@
+{
+  "UNK": [
+    "Col1a1",
+    "Col3a1",
+    "Tcf21",
+    "Sparcl1",
+    "Col1a2",
+    "Islr",
+    "Gap43",
+    "Sfrp1",
+    "6330403K07Rik",
+    "Mfap4",
+    "Ambp",
+    "Smoc2",
+    "Vtn",
+    "Des",
+    "Gas1",
+    "Cldn6",
+    "P2rx1",
+    "Col6a1",
+    "Gc",
+    "Wfdc2"
+  ],
+  "acinar": [
+    "Try10",
+    "Prss1",
+    "Ass1",
+    "Erp27",
+    "Cel",
+    "Serpini2",
+    "Aqp8",
+    "Gm10334",
+    "Arhgdig",
+    "Cela3b",
+    "Cela2a",
+    "Gm5771",
+    "Try5",
+    "Ctrb1",
+    "Dhx34",
+    "Gm15915",
+    "Spink1",
+    "Rbpjl",
+    "Prss3",
+    "Kctd14"
+  ],
+  "adult-alpha": [
+    "Muc1",
+    "Ctrb1",
+    "Cldn10",
+    "Prss1",
+    "Nudt19",
+    "Ass1",
+    "Cldn3",
+    "Mgst1",
+    "Gsta3",
+    "Try10",
+    "Anpep",
+    "Adamts9",
+    "Bicc1",
+    "Tinagl1",
+    "Prss8",
+    "Bst2",
+    "Aldh1b1",
+    "Rap1gap",
+    "Pnliprp1",
+    "Krt19"
+  ],
+  "adult-beta": [
+    "Prss1",
+    "Try10",
+    "Cdca3",
+    "Muc1",
+    "Tinagl1",
+    "Cenpf",
+    "Ccnb1",
+    "Plk1",
+    "Cdc20",
+    "Gm10334",
+    "Ass1",
+    "Tpx2",
+    "Ube2c",
+    "Anpep",
+    "Adamts9",
+    "Birc5",
+    "Ctrb1",
+    "Ccna2",
+    "Rap1gap",
+    "Bicc1"
+  ],
+  "alpha": [
+    "Cck",
+    "Igfbpl1",
+    "Gfra3",
+    "Vwa5b2",
+    "Arx",
+    "Btbd17",
+    "Rph3al",
+    "Mfng",
+    "Ppp1r14a",
+    "Irx2",
+    "Ptn",
+    "Sct",
+    "Neurog3",
+    "Tubb3",
+    "Sult2b1",
+    "Hpca",
+    "Tmem27",
+    "Pax4",
+    "Irx1",
+    "Neurod2"
+  ],
+  "beta": [
+    "2810417H13Rik",
+    "Pax4",
+    "Birc5",
+    "Cdk1",
+    "Top2a",
+    "Spc24",
+    "Gfra3",
+    "Cdca3",
+    "Slc4a1",
+    "Tubb3",
+    "Ccna2",
+    "Cdca8",
+    "Aurkb",
+    "Pbk",
+    "Tyms",
+    "Vwa5b2",
+    "Tk1",
+    "Smc4",
+    "Cldn10",
+    "Fev"
+  ],
+  "delta": [
+    "Cldn10",
+    "Phgdh",
+    "Ctrb1",
+    "Cpa2",
+    "Rbpjl",
+    "Col1a1",
+    "Mfap4",
+    "Tcf21",
+    "Cpa1",
+    "Sparcl1",
+    "Col3a1",
+    "Clps",
+    "Bex4",
+    "Spink1",
+    "Smco4",
+    "Wfdc15b",
+    "Gamt",
+    "Cel",
+    "Pnliprp1",
+    "Mgst1"
+  ],
+  "ductal": [
+    "Tubb2b",
+    "Igfbp2",
+    "Ung",
+    "Igfbp4",
+    "Ccne1",
+    "Rtn1",
+    "E2f1",
+    "Pcbp4",
+    "Irx2",
+    "BC048546",
+    "Pcna",
+    "Slc9a3r1",
+    "Gm266",
+    "Mcm5",
+    "Agtr2",
+    "Mcm3",
+    "Ndn",
+    "Arx",
+    "Rpa2",
+    "Ccne2"
+  ],
+  "endocrine-progenitor": [
+    "Ctrb1",
+    "Cldn10",
+    "Prss1",
+    "Try10",
+    "Adamts9",
+    "Spink1",
+    "Cel",
+    "Serpini2",
+    "Gm10334",
+    "Bst2",
+    "Erp27",
+    "Pnliprp1",
+    "Aldh1b1",
+    "Muc1",
+    "Clps",
+    "Fam81a",
+    "Mgst1",
+    "Try5",
+    "Ass1",
+    "Tmem97"
+  ],
+  "endothelial": [
+    "Cdh5",
+    "Gimap6",
+    "Icam2",
+    "Esam",
+    "Pecam1",
+    "Ecscr",
+    "Myct1",
+    "Gimap4",
+    "Cldn5",
+    "Clec14a",
+    "Aplnr",
+    "Fabp4",
+    "Eng",
+    "Col4a1",
+    "Tmem204",
+    "Cd34",
+    "Col15a1",
+    "Madcam1",
+    "Emcn",
+    "Gimap5"
+  ],
+  "epsilon": [
+    "Serpina1c",
+    "Serpina1e",
+    "Mnx1",
+    "Gm2694",
+    "Adra2a",
+    "Serpina1b",
+    "Arx",
+    "Pabpn1l",
+    "U2af1l4",
+    "Ube2s",
+    "Serpina1a",
+    "Mapt",
+    "Cbx3",
+    "Tcf21",
+    "Pgam1",
+    "Mfap4",
+    "Ctrb1",
+    "Gm266",
+    "Rangrf",
+    "Npepl1"
+  ],
+  "gamma": [
+    "Col3a1",
+    "Col1a1",
+    "Sparcl1",
+    "Col1a2",
+    "Tcf21",
+    "Cnn2",
+    "Sfrp1",
+    "Pdx1",
+    "Lgals1",
+    "Tubb3",
+    "Lhfp",
+    "Gas1",
+    "Bgn",
+    "Col6a1",
+    "6330403K07Rik",
+    "Cmtm3",
+    "Glipr2",
+    "Emp3",
+    "Des",
+    "Rcn3"
+  ],
+  "immune": [
+    "Rac2",
+    "Ly86",
+    "Fcgr3",
+    "Coro1a",
+    "Spi1",
+    "Arhgdib",
+    "Csf1r",
+    "Evi2a",
+    "Adgre1",
+    "AB124611",
+    "Clec4a2",
+    "Tnfaip8l2",
+    "Bin2",
+    "Lcp1",
+    "Cd53",
+    "Laptm5",
+    "Ncf2",
+    "Trem2",
+    "Cx3cr1",
+    "Ms4a6c"
+  ],
+  "mesenchymal": [
+    "Tcf21",
+    "Sfrp1",
+    "Serpina1e",
+    "Cxcl12",
+    "Serpina1c",
+    "Hmga1",
+    "Mfap4",
+    "6330403K07Rik",
+    "Tgfbi",
+    "Vtn",
+    "Sparcl1",
+    "Nefl",
+    "Tac2",
+    "Pgam1",
+    "Gc",
+    "Gap43",
+    "Hist1h2ap",
+    "Serpina1b",
+    "Matn4",
+    "Ube2i"
+  ],
+  "other": [
+    "Cldn10",
+    "Ctrb1",
+    "Tcf21",
+    "Phgdh",
+    "Aldh1b1",
+    "Clps",
+    "Mgst1",
+    "Muc1",
+    "Ube2i",
+    "Wfdc15b",
+    "Nudt19",
+    "Akr1c19",
+    "Ube2s",
+    "Cldn6",
+    "Sparcl1",
+    "Cpa2",
+    "Ambp",
+    "Wfdc2",
+    "Spink1",
+    "Pnliprp1"
+  ],
+  "unassigned": [
+    "Tinagl1",
+    "Mest",
+    "Col9a3",
+    "Dcdc2a",
+    "Gpx2",
+    "Ppp1r1b",
+    "Grin3a",
+    "Igfbp4",
+    "Pdzk1ip1",
+    "Prss1",
+    "Chst2",
+    "Car14",
+    "Ung",
+    "Neurog3",
+    "Bicc1",
+    "Try10",
+    "Lurap1l",
+    "Vtn",
+    "Muc1",
+    "Kctd14"
+  ]
+}

discovery/hematopoiesis/marker/108_dahlin_lineage_metabolism.csv

@@ -0,0 +1,37 @@
+class,module,delta,mean_Kit_W41,mean_WT,n_Kit_W41,n_WT,mannu_p,mannu_p_adj_bonferroni
+LT-HSC,OXPHOS_ETC,0.21889224002979427,-0.06173988681369356,-0.2806321268434878,25,135,9.233959398226166e-05,0.00332422538336142
+LT-HSC,Glycolysis,0.023726293262434583,0.48071656710306804,0.45699027384063345,25,135,0.3078394492874411,1.0
+LT-HSC,Fatty_acid_oxidation,-0.03457489758558233,-0.04393524980545044,-0.009360352219868105,25,135,0.3168420495614016,1.0
+LT-HSC,Redox_glutathione,0.05791827416394757,0.38434242106846406,0.3264241469045165,25,135,0.10001438775913245,1.0
+MPP,OXPHOS_ETC,0.13810220425560676,0.13056083058538756,-0.007541373670219212,3823,27931,1.6794578453456652e-267,6.046048243244395e-266
+MPP,Glycolysis,0.0630032549728764,0.526642821284012,0.46363956631113556,3823,27931,2.7477169266219394e-68,9.891780935838982e-67
+MPP,Fatty_acid_oxidation,-0.009211302547165734,-0.07152597392811433,-0.062314671380948594,3823,27931,0.02332167120455899,0.8395801633641237
+MPP,Redox_glutathione,0.058843916185097656,0.5124303557248863,0.4535864395397886,3823,27931,4.5303514590437206e-130,1.6309265252557395e-128
+basophil-mast,OXPHOS_ETC,-0.036007806842220255,-0.13582515861874536,-0.0998173517765251,245,603,0.022888525696528033,0.8239869250750091
+basophil-mast,Glycolysis,0.05751399348831421,0.5010217289697556,0.4435077354814414,245,603,0.00040951338200332857,0.014742481752119828
+basophil-mast,Fatty_acid_oxidation,0.015842755094490804,-0.060048158539483684,-0.07589091363397449,245,603,0.17323088612161264,1.0
+basophil-mast,Redox_glutathione,0.037277339960249956,0.5900023596178922,0.5527250196576422,245,603,0.002224739481073141,0.08009062131863307
+erythroid,OXPHOS_ETC,0.11540954328095804,0.14733195130192003,0.03192240802096199,7045,8352,2.5168212973789403e-258,9.060556670564185e-257
+erythroid,Glycolysis,0.05080145743119935,0.42942914239777863,0.3786276849665793,7045,8352,1.482105338491084e-97,5.335579218567902e-96
+erythroid,Fatty_acid_oxidation,-0.06026477047720431,-0.08037019422570385,-0.020105423748499537,7045,8352,2.4014629679788924e-173,8.645266684724013e-172
+erythroid,Redox_glutathione,0.07211286538205641,0.6990433078864495,0.6269304425043931,7045,8352,3.888946383197969e-235,1.4000206979512688e-233
+lymphoid,OXPHOS_ETC,0.19610006655488352,0.29157076629484546,0.09547069973996195,55,639,8.522346370816427e-08,3.0680446934939137e-06
+lymphoid,Glycolysis,0.038821364441959105,0.3760875817212192,0.3372662172792601,55,639,0.238421273506783,1.0
+lymphoid,Fatty_acid_oxidation,-0.002216360316330261,0.004068565000158248,0.006284925316488509,55,639,0.9307401266605169,1.0
+lymphoid,Redox_glutathione,0.09464514051174588,0.4904313762466629,0.395786235734917,55,639,0.00016082103657113797,0.005789557316560967
+macrophage,OXPHOS_ETC,0.043586395505874925,0.2167083744271092,0.17312197892123427,21,42,0.39368851798913085,1.0
+macrophage,Glycolysis,0.19010290362349064,0.6178738759593114,0.4277709723358208,21,42,0.0021466710591654323,0.07728015812995556
+macrophage,Fatty_acid_oxidation,-0.041974740960971015,0.0027829228020579385,0.044757663763028956,21,42,0.21253858326116026,1.0
+macrophage,Redox_glutathione,0.09848458604747734,0.41749638252517796,0.3190117964777006,21,42,0.014018855055126546,0.5046787819845556
+megakaryocyte,OXPHOS_ETC,0.1004160574047118,-0.035532044318789986,-0.13594810172350177,1584,6596,3.532796721102679e-60,1.2718068195969644e-58
+megakaryocyte,Glycolysis,0.015523421808893767,0.45573081887763417,0.4402073970687404,1584,6596,0.015714177308280924,0.5657103830981133
+megakaryocyte,Fatty_acid_oxidation,-0.012146193213383047,-0.03475183718918282,-0.022605643975799776,1584,6596,0.011556039152293768,0.41601740948257565
+megakaryocyte,Redox_glutathione,0.05665095809995585,0.5508340679302188,0.494183109830263,1584,6596,2.549494835855986e-44,9.17818140908155e-43
+monocyte,OXPHOS_ETC,0.02320383137875305,0.11835046145904173,0.09514663008028867,157,315,0.22501497426865902,1.0
+monocyte,Glycolysis,0.012818666789436772,0.6042148906863257,0.591396223896889,157,315,0.6590680970628982,1.0
+monocyte,Fatty_acid_oxidation,0.01879129144674451,-0.052130496851905815,-0.07092178829865033,157,315,0.15803911852154406,1.0
+monocyte,Redox_glutathione,0.027495184623933855,0.6095390911727085,0.5820439065487747,157,315,0.025629161154232187,0.9226498015523588
+myeloid,OXPHOS_ETC,-0.0080709356006157,0.027514217589360828,0.03558515318997653,1708,1755,0.05169422544038418,1.0
+myeloid,Glycolysis,0.07319976427779318,0.6619220945352131,0.5887223302574199,1708,1755,9.487440007056612e-53,3.4154784025403804e-51
+myeloid,Fatty_acid_oxidation,0.014392573376853665,-0.06733933606333575,-0.08173190944018942,1708,1755,0.00010780322592052838,0.0038809161331390214
+myeloid,Redox_glutathione,0.02587857827994622,0.6335450023550171,0.6076664240750709,1708,1755,5.01153589645176e-12,1.8041529227226335e-10

discovery/hematopoiesis/marker/108_dahlin_lineage_metabolism.json

@@ -0,0 +1,54 @@
+{
+  "modules": [
+    "OXPHOS_ETC",
+    "Glycolysis",
+    "Fatty_acid_oxidation",
+    "Redox_glutathione"
+  ],
+  "top_lineage": "macrophage",
+  "top_sum_abs_delta": 0.3741486261378139,
+  "top_deltas_per_module": {
+    "OXPHOS_ETC": 0.043586395505874925,
+    "Glycolysis": 0.19010290362349064,
+    "Fatty_acid_oxidation": -0.041974740960971015,
+    "Redox_glutathione": 0.09848458604747734
+  },
+  "ranking": [
+    {
+      "class": "macrophage",
+      "sum_abs_delta": 0.3741486261378139
+    },
+    {
+      "class": "LT-HSC",
+      "sum_abs_delta": 0.33511170504175875
+    },
+    {
+      "class": "lymphoid",
+      "sum_abs_delta": 0.3317829318249188
+    },
+    {
+      "class": "erythroid",
+      "sum_abs_delta": 0.2985886365714181
+    },
+    {
+      "class": "MPP",
+      "sum_abs_delta": 0.26916067796074655
+    },
+    {
+      "class": "megakaryocyte",
+      "sum_abs_delta": 0.18473663052694445
+    },
+    {
+      "class": "basophil-mast",
+      "sum_abs_delta": 0.14664189538527522
+    },
+    {
+      "class": "myeloid",
+      "sum_abs_delta": 0.12154185153520876
+    },
+    {
+      "class": "monocyte",
+      "sum_abs_delta": 0.08230897423886818
+    }
+  ]
+}

discovery/hematopoiesis/marker/108_dahlin_lineage_metabolism_ranked.csv

@@ -0,0 +1,10 @@
+class,Fatty_acid_oxidation,Glycolysis,OXPHOS_ETC,Redox_glutathione,sum_abs_delta,l2_delta
+macrophage,-0.041974740960971015,0.19010290362349064,0.043586395505874925,0.09848458604747734,0.3741486261378139,0.22248591058078332
+LT-HSC,-0.03457489758558233,0.023726293262434583,0.21889224002979427,0.05791827416394757,0.33511170504175875,0.23027526954152028
+lymphoid,-0.002216360316330261,0.038821364441959105,0.19610006655488352,0.09464514051174588,0.3317829318249188,0.2211898490335962
+erythroid,-0.06026477047720431,0.05080145743119935,0.11540954328095804,0.07211286538205641,0.2985886365714181,0.15726493147467427
+MPP,-0.009211302547165734,0.0630032549728764,0.13810220425560676,0.058843916185097656,0.26916067796074655,0.16306159426440311
+megakaryocyte,-0.012146193213383047,0.015523421808893767,0.1004160574047118,0.05665095809995585,0.18473663052694445,0.11696675712604415
+basophil-mast,0.015842755094490804,0.05751399348831421,-0.036007806842220255,0.037277339960249956,0.14664189538527522,0.07902540454851563
+myeloid,0.014392573376853665,0.07319976427779318,-0.0080709356006157,0.02587857827994622,0.12154185153520876,0.07937375179486725
+monocyte,0.01879129144674451,0.012818666789436772,0.02320383137875305,0.027495184623933855,0.08230897423886818,0.04256564131612392

discovery/hematopoiesis/marker/57_pathway_analysis.csv

@@ -0,0 +1,271 @@
+class,module_name,module_type,citation,direction,n_g1,n_g2,group_g1,group_g2,delta,mannu_p,mannu_p_adj_bonferroni
+LT-HSC,Kit_signaling,signaling,Lennartsson-2012,,25,135,Kit_W41,WT,-0.4509,1.573438745435808e-08,4.248284612676681e-06
+LT-HSC,Kit_ligand,signaling,Broudy-1997,,25,135,Kit_W41,WT,-0.3438,5.636010838160408e-06,0.0015217229263033102
+LT-HSC,MYC_targets,lineage,Dang-2012,,25,135,Kit_W41,WT,-0.0609,0.3976147519565305,1.0
+LT-HSC,Cell_cycle,cycle,Whitfield-2002,,25,135,Kit_W41,WT,0.0598,0.10001438775913245,1.0
+LT-HSC,DNA_replication,cycle,Bell-2002,,25,135,Kit_W41,WT,0.0103,0.5953978351491119,1.0
+LT-HSC,Integrated_stress,stress,Pakos-Zebrucka-2016,,25,135,Kit_W41,WT,0.0564,0.0718821939157507,1.0
+LT-HSC,Apoptosis_pro,stress,Youle-2008,,25,135,Kit_W41,WT,0.0375,0.35212378558040536,1.0
+LT-HSC,Apoptosis_anti,stress,Adams-2018,,25,135,Kit_W41,WT,0.018,0.4492891910725191,1.0
+LT-HSC,Erythropoiesis_early,lineage,Palis-2014,,25,135,Kit_W41,WT,-0.0839,0.03211964916653082,1.0
+LT-HSC,Erythropoiesis_late,lineage,Palis-2014,,25,135,Kit_W41,WT,0.0682,0.01101048301119987,1.0
+LT-HSC,Granulopoiesis,lineage,Rosenbauer-2007,,25,135,Kit_W41,WT,0.2185,0.00024683810135600604,0.06664628736612163
+LT-HSC,Lymphopoiesis_B,lineage,Nutt-2011,,25,135,Kit_W41,WT,0.0385,0.2199554255079016,1.0
+LT-HSC,Lymphopoiesis_T,lineage,Rothenberg-2014,,25,135,Kit_W41,WT,-0.0118,0.6451290358390585,1.0
+LT-HSC,Megakaryopoiesis,lineage,Tijssen-2013,,25,135,Kit_W41,WT,-0.0465,0.17442511945314387,1.0
+LT-HSC,Basophil_mast,lineage,Voehringer-2013,,25,135,Kit_W41,WT,0.0009,0.631698892589284,1.0
+LT-HSC,Hemostasis,signaling,Furie-2008,,25,135,Kit_W41,WT,0.0072,0.00641765921724996,1.0
+LT-HSC,OXPHOS_ETC,metabolism,Mishra-2016,,25,135,Kit_W41,WT,0.2189,9.233959398226166e-05,0.02493169037521065
+LT-HSC,Glycolysis,metabolism,Vander-Heiden-2009,,25,135,Kit_W41,WT,0.0237,0.3078394492874411,1.0
+LT-HSC,TCA,metabolism,Chandel-2015,,25,135,Kit_W41,WT,0.0042,0.7671834219558633,1.0
+LT-HSC,Redox_glutathione,stress,Ho-2007,,25,135,Kit_W41,WT,0.0579,0.10001438775913245,1.0
+LT-HSC,Wnt_hemato,signaling,Reya-2003,,25,135,Kit_W41,WT,-0.0238,0.36940840695372124,1.0
+LT-HSC,Notch_hemato,signaling,Bigas-2018,,25,135,Kit_W41,WT,-0.0212,0.9139276338767109,1.0
+LT-HSC,TGFb_hemato,signaling,Blank-2015,,25,135,Kit_W41,WT,-0.0069,0.7743708813364071,1.0
+LT-HSC,IFN_signaling,immune,Essers-2009,,25,135,Kit_W41,WT,-0.0717,0.1209505245948936,1.0
+LT-HSC,Complement,immune,Ricklin-2016,,25,135,Kit_W41,WT,0.0228,0.018788988659623345,1.0
+LT-HSC,NK_cytotoxicity,immune,Vivier-2011,,25,135,Kit_W41,WT,0.0178,0.2476614838484108,1.0
+LT-HSC,Mast_cell_degran,immune,Galli-2011,,25,135,Kit_W41,WT,-0.0504,0.006509608839218461,1.0
+LT-HSC,Autophagy,stress,Warr-2013,,25,135,Kit_W41,WT,0.0507,0.1009875994046882,1.0
+LT-HSC,Senescence,stress,Chang-2016,,25,135,Kit_W41,WT,0.0414,0.02591338774875685,1.0
+LT-HSC,LT_HSC_quiescence,lineage,Cabezas-Wallscheid-2017,,25,135,Kit_W41,WT,-0.2871,5.762965782466499e-06,0.0015560007612659547
+MPP,Kit_signaling,signaling,Lennartsson-2012,,3823,27931,Kit_W41,WT,-0.2712,0.0,0.0
+MPP,Kit_ligand,signaling,Broudy-1997,,3823,27931,Kit_W41,WT,-0.2744,0.0,0.0
+MPP,MYC_targets,lineage,Dang-2012,,3823,27931,Kit_W41,WT,-0.0041,0.04286864928329066,1.0
+MPP,Cell_cycle,cycle,Whitfield-2002,,3823,27931,Kit_W41,WT,0.029,7.711641645989381e-20,2.082143244417133e-17
+MPP,DNA_replication,cycle,Bell-2002,,3823,27931,Kit_W41,WT,-0.0143,0.5888273922631535,1.0
+MPP,Integrated_stress,stress,Pakos-Zebrucka-2016,,3823,27931,Kit_W41,WT,0.0208,5.0227808871017416e-31,1.3561508395174703e-28
+MPP,Apoptosis_pro,stress,Youle-2008,,3823,27931,Kit_W41,WT,0.0674,1.926047068279582e-127,5.200327084354871e-125
+MPP,Apoptosis_anti,stress,Adams-2018,,3823,27931,Kit_W41,WT,-0.0378,1.4673648522651677e-38,3.961885101115953e-36
+MPP,Erythropoiesis_early,lineage,Palis-2014,,3823,27931,Kit_W41,WT,-0.0197,9.687428623167843e-29,2.6156057282553174e-26
+MPP,Erythropoiesis_late,lineage,Palis-2014,,3823,27931,Kit_W41,WT,0.0396,3.3314982747637047e-289,8.995045341862003e-287
+MPP,Granulopoiesis,lineage,Rosenbauer-2007,,3823,27931,Kit_W41,WT,0.2763,0.0,0.0
+MPP,Lymphopoiesis_B,lineage,Nutt-2011,,3823,27931,Kit_W41,WT,0.0076,4.074900969976706e-71,1.1002232618937107e-68
+MPP,Lymphopoiesis_T,lineage,Rothenberg-2014,,3823,27931,Kit_W41,WT,-0.0013,5.866330939803875e-05,0.015839093537470463
+MPP,Megakaryopoiesis,lineage,Tijssen-2013,,3823,27931,Kit_W41,WT,-0.0304,7.885870844445077e-33,2.1291851280001707e-30
+MPP,Basophil_mast,lineage,Voehringer-2013,,3823,27931,Kit_W41,WT,0.05,6.288248607769962e-146,1.6978271240978898e-143
+MPP,Hemostasis,signaling,Furie-2008,,3823,27931,Kit_W41,WT,0.007,7.587363312728632e-179,2.0485880944367307e-176
+MPP,OXPHOS_ETC,metabolism,Mishra-2016,,3823,27931,Kit_W41,WT,0.1381,1.6794578453456652e-267,4.534536182433296e-265
+MPP,Glycolysis,metabolism,Vander-Heiden-2009,,3823,27931,Kit_W41,WT,0.063,2.7477169266219394e-68,7.418835701879237e-66
+MPP,TCA,metabolism,Chandel-2015,,3823,27931,Kit_W41,WT,0.0549,4.2660244205410085e-68,1.1518265935460723e-65
+MPP,Redox_glutathione,stress,Ho-2007,,3823,27931,Kit_W41,WT,0.0588,4.5303514590437206e-130,1.2231948939418045e-127
+MPP,Wnt_hemato,signaling,Reya-2003,,3823,27931,Kit_W41,WT,-0.0031,3.01580555155226e-06,0.0008142674989191102
+MPP,Notch_hemato,signaling,Bigas-2018,,3823,27931,Kit_W41,WT,-0.0212,0.004970940753378295,1.0
+MPP,TGFb_hemato,signaling,Blank-2015,,3823,27931,Kit_W41,WT,0.0005,0.04987740861393767,1.0
+MPP,IFN_signaling,immune,Essers-2009,,3823,27931,Kit_W41,WT,-0.0173,0.008371929086522545,1.0
+MPP,Complement,immune,Ricklin-2016,,3823,27931,Kit_W41,WT,0.0047,2.0400189606893648e-180,5.508051193861285e-178
+MPP,NK_cytotoxicity,immune,Vivier-2011,,3823,27931,Kit_W41,WT,0.0268,7.867813609801058e-76,2.1243096746462854e-73
+MPP,Mast_cell_degran,immune,Galli-2011,,3823,27931,Kit_W41,WT,-0.0269,7.662887755599684e-55,2.0689796940119147e-52
+MPP,Autophagy,stress,Warr-2013,,3823,27931,Kit_W41,WT,-0.0033,0.8995292221125352,1.0
+MPP,Senescence,stress,Chang-2016,,3823,27931,Kit_W41,WT,0.0035,0.003855349142459463,1.0
+MPP,LT_HSC_quiescence,lineage,Cabezas-Wallscheid-2017,,3823,27931,Kit_W41,WT,-0.154,0.0,0.0
+basophil-mast,Kit_signaling,signaling,Lennartsson-2012,,245,603,Kit_W41,WT,-0.2462,1.3013603466371271e-22,3.5136729359202435e-20
+basophil-mast,Kit_ligand,signaling,Broudy-1997,,245,603,Kit_W41,WT,-0.2422,4.684615475054218e-16,1.2648461782646388e-13
+basophil-mast,MYC_targets,lineage,Dang-2012,,245,603,Kit_W41,WT,-0.0712,6.292788880997305e-05,0.016990529978692725
+basophil-mast,Cell_cycle,cycle,Whitfield-2002,,245,603,Kit_W41,WT,-0.0678,0.0010613216287483403,0.2865568397620519
+basophil-mast,DNA_replication,cycle,Bell-2002,,245,603,Kit_W41,WT,-0.0791,0.0011771447631818471,0.3178290860590987
+basophil-mast,Integrated_stress,stress,Pakos-Zebrucka-2016,,245,603,Kit_W41,WT,0.0323,0.0006611499284012064,0.17851048066832573
+basophil-mast,Apoptosis_pro,stress,Youle-2008,,245,603,Kit_W41,WT,0.0125,0.22425850882568865,1.0
+basophil-mast,Apoptosis_anti,stress,Adams-2018,,245,603,Kit_W41,WT,-0.0277,0.027146343120943415,1.0
+basophil-mast,Erythropoiesis_early,lineage,Palis-2014,,245,603,Kit_W41,WT,0.016,0.07425602791621094,1.0
+basophil-mast,Erythropoiesis_late,lineage,Palis-2014,,245,603,Kit_W41,WT,0.037,1.814278212945147e-08,4.898551174951897e-06
+basophil-mast,Granulopoiesis,lineage,Rosenbauer-2007,,245,603,Kit_W41,WT,0.1481,2.2215865594685673e-06,0.0005998283710565132
+basophil-mast,Lymphopoiesis_B,lineage,Nutt-2011,,245,603,Kit_W41,WT,0.0022,0.005186860882984191,1.0
+basophil-mast,Lymphopoiesis_T,lineage,Rothenberg-2014,,245,603,Kit_W41,WT,-0.0086,0.5644489071847358,1.0
+basophil-mast,Megakaryopoiesis,lineage,Tijssen-2013,,245,603,Kit_W41,WT,-0.0435,0.0001383955055330826,0.037366786493932304
+basophil-mast,Basophil_mast,lineage,Voehringer-2013,,245,603,Kit_W41,WT,-0.0282,0.3427954906523554,1.0
+basophil-mast,Hemostasis,signaling,Furie-2008,,245,603,Kit_W41,WT,0.0012,0.2644002898393235,1.0
+basophil-mast,OXPHOS_ETC,metabolism,Mishra-2016,,245,603,Kit_W41,WT,-0.036,0.022888525696528033,1.0
+basophil-mast,Glycolysis,metabolism,Vander-Heiden-2009,,245,603,Kit_W41,WT,0.0575,0.00040951338200332857,0.11056861314089872
+basophil-mast,TCA,metabolism,Chandel-2015,,245,603,Kit_W41,WT,0.0495,0.00010865424766668716,0.029336646870005534
+basophil-mast,Redox_glutathione,stress,Ho-2007,,245,603,Kit_W41,WT,0.0373,0.002224739481073141,0.600679659889748
+basophil-mast,Wnt_hemato,signaling,Reya-2003,,245,603,Kit_W41,WT,0.0044,0.00021667368611011557,0.058501895249731206
+basophil-mast,Notch_hemato,signaling,Bigas-2018,,245,603,Kit_W41,WT,-0.0244,0.7169692681946584,1.0
+basophil-mast,TGFb_hemato,signaling,Blank-2015,,245,603,Kit_W41,WT,-0.0026,0.830031090922129,1.0
+basophil-mast,IFN_signaling,immune,Essers-2009,,245,603,Kit_W41,WT,-0.0039,0.29824132032329864,1.0
+basophil-mast,Complement,immune,Ricklin-2016,,245,603,Kit_W41,WT,-0.0022,0.022230241638256237,1.0
+basophil-mast,NK_cytotoxicity,immune,Vivier-2011,,245,603,Kit_W41,WT,0.0036,0.001010221654307808,0.27275984666310815
+basophil-mast,Mast_cell_degran,immune,Galli-2011,,245,603,Kit_W41,WT,-0.0575,0.012359661111537733,1.0
+basophil-mast,Autophagy,stress,Warr-2013,,245,603,Kit_W41,WT,0.0225,0.03664442060101316,1.0
+basophil-mast,Senescence,stress,Chang-2016,,245,603,Kit_W41,WT,-0.0171,0.09935104494491875,1.0
+basophil-mast,LT_HSC_quiescence,lineage,Cabezas-Wallscheid-2017,,245,603,Kit_W41,WT,-0.032,0.007968002270345659,1.0
+erythroid,Kit_signaling,signaling,Lennartsson-2012,,7045,8352,Kit_W41,WT,-0.243,0.0,0.0
+erythroid,Kit_ligand,signaling,Broudy-1997,,7045,8352,Kit_W41,WT,-0.2158,0.0,0.0
+erythroid,MYC_targets,lineage,Dang-2012,,7045,8352,Kit_W41,WT,-0.0059,1.4371711061942026e-16,3.880361986724347e-14
+erythroid,Cell_cycle,cycle,Whitfield-2002,,7045,8352,Kit_W41,WT,0.022,0.7024682871597441,1.0
+erythroid,DNA_replication,cycle,Bell-2002,,7045,8352,Kit_W41,WT,-0.0583,2.201751765854284e-74,5.944729767806566e-72
+erythroid,Integrated_stress,stress,Pakos-Zebrucka-2016,,7045,8352,Kit_W41,WT,0.0191,1.9239058981688488e-45,5.194545925055892e-43
+erythroid,Apoptosis_pro,stress,Youle-2008,,7045,8352,Kit_W41,WT,-0.0173,8.351490030576401e-16,2.2549023082556283e-13
+erythroid,Apoptosis_anti,stress,Adams-2018,,7045,8352,Kit_W41,WT,-0.0184,1.228745347741732e-05,0.0033176124389026765
+erythroid,Erythropoiesis_early,lineage,Palis-2014,,7045,8352,Kit_W41,WT,-0.0407,1.8331299065672826e-55,4.949450747731663e-53
+erythroid,Erythropoiesis_late,lineage,Palis-2014,,7045,8352,Kit_W41,WT,0.0423,5.729304031115407e-169,1.54691208840116e-166
+erythroid,Granulopoiesis,lineage,Rosenbauer-2007,,7045,8352,Kit_W41,WT,0.0828,0.0,0.0
+erythroid,Lymphopoiesis_B,lineage,Nutt-2011,,7045,8352,Kit_W41,WT,0.0021,2.067046477749755e-109,5.581025489924339e-107
+erythroid,Lymphopoiesis_T,lineage,Rothenberg-2014,,7045,8352,Kit_W41,WT,0.0001,1.0662940922945615e-29,2.878994049195316e-27
+erythroid,Megakaryopoiesis,lineage,Tijssen-2013,,7045,8352,Kit_W41,WT,-0.0329,7.19023966557754e-40,1.941364709705936e-37
+erythroid,Basophil_mast,lineage,Voehringer-2013,,7045,8352,Kit_W41,WT,-0.0492,2.088976862224465e-100,5.6402375280060556e-98
+erythroid,Hemostasis,signaling,Furie-2008,,7045,8352,Kit_W41,WT,0.0022,4.55251828818623e-169,1.2291799378102821e-166
+erythroid,OXPHOS_ETC,metabolism,Mishra-2016,,7045,8352,Kit_W41,WT,0.1154,2.5168212973789403e-258,6.795417502923138e-256
+erythroid,Glycolysis,metabolism,Vander-Heiden-2009,,7045,8352,Kit_W41,WT,0.0508,1.482105338491084e-97,4.001684413925927e-95
+erythroid,TCA,metabolism,Chandel-2015,,7045,8352,Kit_W41,WT,0.0143,0.00024912079045345153,0.06726261342243191
+erythroid,Redox_glutathione,stress,Ho-2007,,7045,8352,Kit_W41,WT,0.0721,3.888946383197969e-235,1.0500155234634517e-232
+erythroid,Wnt_hemato,signaling,Reya-2003,,7045,8352,Kit_W41,WT,-0.0115,2.7170984240119944e-13,7.336165744832385e-11
+erythroid,Notch_hemato,signaling,Bigas-2018,,7045,8352,Kit_W41,WT,-0.0192,6.285057182116871e-10,1.6969654391715552e-07
+erythroid,TGFb_hemato,signaling,Blank-2015,,7045,8352,Kit_W41,WT,-0.0419,2.2894953413913045e-108,6.181637421756523e-106
+erythroid,IFN_signaling,immune,Essers-2009,,7045,8352,Kit_W41,WT,-0.0058,0.00017752721683558787,0.047932348545608724
+erythroid,Complement,immune,Ricklin-2016,,7045,8352,Kit_W41,WT,-0.0,1.9505464507798007e-12,5.266475417105462e-10
+erythroid,NK_cytotoxicity,immune,Vivier-2011,,7045,8352,Kit_W41,WT,-0.0176,0.0012137437817675988,0.3277108210772517
+erythroid,Mast_cell_degran,immune,Galli-2011,,7045,8352,Kit_W41,WT,-0.0542,0.0,0.0
+erythroid,Autophagy,stress,Warr-2013,,7045,8352,Kit_W41,WT,-0.0233,7.606459809540424e-23,2.0537441485759147e-20
+erythroid,Senescence,stress,Chang-2016,,7045,8352,Kit_W41,WT,-0.0398,3.666520646651079e-264,9.899605745957913e-262
+erythroid,LT_HSC_quiescence,lineage,Cabezas-Wallscheid-2017,,7045,8352,Kit_W41,WT,-0.0176,5.444069612517442e-29,1.4698987953797095e-26
+lymphoid,Kit_signaling,signaling,Lennartsson-2012,,55,639,Kit_W41,WT,-0.2701,2.424669228453631e-08,6.546606916824804e-06
+lymphoid,Kit_ligand,signaling,Broudy-1997,,55,639,Kit_W41,WT,-0.3338,5.44298529826988e-12,1.4696060305328676e-09
+lymphoid,MYC_targets,lineage,Dang-2012,,55,639,Kit_W41,WT,0.0993,0.00779830243691531,1.0
+lymphoid,Cell_cycle,cycle,Whitfield-2002,,55,639,Kit_W41,WT,0.0563,0.008648770905465161,1.0
+lymphoid,DNA_replication,cycle,Bell-2002,,55,639,Kit_W41,WT,0.0649,0.0014027836008362801,0.37875157222579564
+lymphoid,Integrated_stress,stress,Pakos-Zebrucka-2016,,55,639,Kit_W41,WT,-0.0025,0.7019418044931746,1.0
+lymphoid,Apoptosis_pro,stress,Youle-2008,,55,639,Kit_W41,WT,0.0957,0.00021727335768022935,0.05866380657366192
+lymphoid,Apoptosis_anti,stress,Adams-2018,,55,639,Kit_W41,WT,-0.036,0.41417533166190734,1.0
+lymphoid,Erythropoiesis_early,lineage,Palis-2014,,55,639,Kit_W41,WT,-0.0124,0.2656844563968216,1.0
+lymphoid,Erythropoiesis_late,lineage,Palis-2014,,55,639,Kit_W41,WT,0.0144,6.01943703215153e-05,0.01625247998680913
+lymphoid,Granulopoiesis,lineage,Rosenbauer-2007,,55,639,Kit_W41,WT,0.0925,2.0901622634399658e-06,0.0005643438111287908
+lymphoid,Lymphopoiesis_B,lineage,Nutt-2011,,55,639,Kit_W41,WT,0.0383,0.29148032997818596,1.0
+lymphoid,Lymphopoiesis_T,lineage,Rothenberg-2014,,55,639,Kit_W41,WT,0.076,0.002439357620661302,0.6586265575785515
+lymphoid,Megakaryopoiesis,lineage,Tijssen-2013,,55,639,Kit_W41,WT,-0.0057,0.7802717831835702,1.0
+lymphoid,Basophil_mast,lineage,Voehringer-2013,,55,639,Kit_W41,WT,0.0041,0.11738419431898701,1.0
+lymphoid,Hemostasis,signaling,Furie-2008,,55,639,Kit_W41,WT,0.0028,0.15382781307208998,1.0
+lymphoid,OXPHOS_ETC,metabolism,Mishra-2016,,55,639,Kit_W41,WT,0.1961,8.522346370816427e-08,2.3010335201204353e-05
+lymphoid,Glycolysis,metabolism,Vander-Heiden-2009,,55,639,Kit_W41,WT,0.0388,0.238421273506783,1.0
+lymphoid,TCA,metabolism,Chandel-2015,,55,639,Kit_W41,WT,0.0745,0.011765695824720288,1.0
+lymphoid,Redox_glutathione,stress,Ho-2007,,55,639,Kit_W41,WT,0.0946,0.00016082103657113797,0.04342167987420725
+lymphoid,Wnt_hemato,signaling,Reya-2003,,55,639,Kit_W41,WT,0.0264,0.005851215370631499,1.0
+lymphoid,Notch_hemato,signaling,Bigas-2018,,55,639,Kit_W41,WT,0.008,0.25441520080255353,1.0
+lymphoid,TGFb_hemato,signaling,Blank-2015,,55,639,Kit_W41,WT,0.0115,0.4541109309343594,1.0
+lymphoid,IFN_signaling,immune,Essers-2009,,55,639,Kit_W41,WT,-0.0227,0.1734567008939467,1.0
+lymphoid,Complement,immune,Ricklin-2016,,55,639,Kit_W41,WT,0.0035,0.00026501484031778784,0.07155400688580271
+lymphoid,NK_cytotoxicity,immune,Vivier-2011,,55,639,Kit_W41,WT,0.1258,7.401893628957206e-05,0.019985112798184455
+lymphoid,Mast_cell_degran,immune,Galli-2011,,55,639,Kit_W41,WT,-0.0594,0.00023990364020311098,0.06477398285483997
+lymphoid,Autophagy,stress,Warr-2013,,55,639,Kit_W41,WT,0.0002,0.7915906603793537,1.0
+lymphoid,Senescence,stress,Chang-2016,,55,639,Kit_W41,WT,0.0551,0.00062351261040224,0.1683484048086048
+lymphoid,LT_HSC_quiescence,lineage,Cabezas-Wallscheid-2017,,55,639,Kit_W41,WT,-0.128,0.0030073987592350686,0.8119976649934685
+macrophage,Kit_signaling,signaling,Lennartsson-2012,,21,42,Kit_W41,WT,-0.1449,0.0038013954791704502,1.0
+macrophage,Kit_ligand,signaling,Broudy-1997,,21,42,Kit_W41,WT,-0.1218,0.3777184532991602,1.0
+macrophage,MYC_targets,lineage,Dang-2012,,21,42,Kit_W41,WT,0.1441,0.06948598088562234,1.0
+macrophage,Cell_cycle,cycle,Whitfield-2002,,21,42,Kit_W41,WT,0.0283,0.7650193459530775,1.0
+macrophage,DNA_replication,cycle,Bell-2002,,21,42,Kit_W41,WT,-0.0104,0.8098846170667502,1.0
+macrophage,Integrated_stress,stress,Pakos-Zebrucka-2016,,21,42,Kit_W41,WT,0.0576,0.023375810203823347,1.0
+macrophage,Apoptosis_pro,stress,Youle-2008,,21,42,Kit_W41,WT,0.0559,0.17280131319450898,1.0
+macrophage,Apoptosis_anti,stress,Adams-2018,,21,42,Kit_W41,WT,0.0507,0.17744061151290724,1.0
+macrophage,Erythropoiesis_early,lineage,Palis-2014,,21,42,Kit_W41,WT,-0.0183,0.6992168547527977,1.0
+macrophage,Erythropoiesis_late,lineage,Palis-2014,,21,42,Kit_W41,WT,0.0478,0.008137189916134113,1.0
+macrophage,Granulopoiesis,lineage,Rosenbauer-2007,,21,42,Kit_W41,WT,0.2101,0.02718056359331326,1.0
+macrophage,Lymphopoiesis_B,lineage,Nutt-2011,,21,42,Kit_W41,WT,0.0,0.0011781580508938793,0.31810267374134743
+macrophage,Lymphopoiesis_T,lineage,Rothenberg-2014,,21,42,Kit_W41,WT,-0.0088,0.5548541509583209,1.0
+macrophage,Megakaryopoiesis,lineage,Tijssen-2013,,21,42,Kit_W41,WT,-0.0068,0.9709229561915323,1.0
+macrophage,Basophil_mast,lineage,Voehringer-2013,,21,42,Kit_W41,WT,-0.0041,0.7100435877726015,1.0
+macrophage,Hemostasis,signaling,Furie-2008,,21,42,Kit_W41,WT,0.0505,0.007793116469810733,1.0
+macrophage,OXPHOS_ETC,metabolism,Mishra-2016,,21,42,Kit_W41,WT,0.0436,0.39368851798913085,1.0
+macrophage,Glycolysis,metabolism,Vander-Heiden-2009,,21,42,Kit_W41,WT,0.1901,0.0021466710591654323,0.5796011859746667
+macrophage,TCA,metabolism,Chandel-2015,,21,42,Kit_W41,WT,0.0625,0.16379577320641248,1.0
+macrophage,Redox_glutathione,stress,Ho-2007,,21,42,Kit_W41,WT,0.0985,0.014018855055126546,1.0
+macrophage,Wnt_hemato,signaling,Reya-2003,,21,42,Kit_W41,WT,-0.0109,0.6671092726212534,1.0
+macrophage,Notch_hemato,signaling,Bigas-2018,,21,42,Kit_W41,WT,-0.0045,0.7318715947598411,1.0
+macrophage,TGFb_hemato,signaling,Blank-2015,,21,42,Kit_W41,WT,-0.0567,0.10094627421673924,1.0
+macrophage,IFN_signaling,immune,Essers-2009,,21,42,Kit_W41,WT,-0.0271,0.9476872666091086,1.0
+macrophage,Complement,immune,Ricklin-2016,,21,42,Kit_W41,WT,0.0027,0.5354799542133517,1.0
+macrophage,NK_cytotoxicity,immune,Vivier-2011,,21,42,Kit_W41,WT,-0.012,0.6460335914571025,1.0
+macrophage,Mast_cell_degran,immune,Galli-2011,,21,42,Kit_W41,WT,-0.0253,0.656537269909282,1.0
+macrophage,Autophagy,stress,Warr-2013,,21,42,Kit_W41,WT,-0.012,0.7761683990501249,1.0
+macrophage,Senescence,stress,Chang-2016,,21,42,Kit_W41,WT,-0.0287,0.25848762408274584,1.0
+macrophage,LT_HSC_quiescence,lineage,Cabezas-Wallscheid-2017,,21,42,Kit_W41,WT,-0.0121,0.41839641532637906,1.0
+megakaryocyte,Kit_signaling,signaling,Lennartsson-2012,,1584,6596,Kit_W41,WT,-0.265,3.8969442293248416e-210,1.0521749419177073e-207
+megakaryocyte,Kit_ligand,signaling,Broudy-1997,,1584,6596,Kit_W41,WT,-0.2031,4.09670152132342e-65,1.1061094107573234e-62
+megakaryocyte,MYC_targets,lineage,Dang-2012,,1584,6596,Kit_W41,WT,0.0518,4.6728769904644514e-14,1.2616767874254019e-11
+megakaryocyte,Cell_cycle,cycle,Whitfield-2002,,1584,6596,Kit_W41,WT,-0.0567,2.760319735661015e-12,7.452863286284741e-10
+megakaryocyte,DNA_replication,cycle,Bell-2002,,1584,6596,Kit_W41,WT,-0.0943,2.4405744057990297e-27,6.5895508956573805e-25
+megakaryocyte,Integrated_stress,stress,Pakos-Zebrucka-2016,,1584,6596,Kit_W41,WT,0.0188,6.166003681216936e-09,1.6648209939285727e-06
+megakaryocyte,Apoptosis_pro,stress,Youle-2008,,1584,6596,Kit_W41,WT,0.0344,2.3100262257675004e-14,6.237070809572251e-12
+megakaryocyte,Apoptosis_anti,stress,Adams-2018,,1584,6596,Kit_W41,WT,-0.0587,2.1570347871515116e-36,5.8239939253090815e-34
+megakaryocyte,Erythropoiesis_early,lineage,Palis-2014,,1584,6596,Kit_W41,WT,-0.0007,0.9917610996602942,1.0
+megakaryocyte,Erythropoiesis_late,lineage,Palis-2014,,1584,6596,Kit_W41,WT,0.0474,1.1974996853455535e-56,3.233249150432994e-54
+megakaryocyte,Granulopoiesis,lineage,Rosenbauer-2007,,1584,6596,Kit_W41,WT,0.0808,1.0756771070132426e-137,2.904328188935755e-135
+megakaryocyte,Lymphopoiesis_B,lineage,Nutt-2011,,1584,6596,Kit_W41,WT,0.0013,2.060488658015515e-41,5.56331937664189e-39
+megakaryocyte,Lymphopoiesis_T,lineage,Rothenberg-2014,,1584,6596,Kit_W41,WT,-0.0126,7.159888746324838e-05,0.019331699615077063
+megakaryocyte,Megakaryopoiesis,lineage,Tijssen-2013,,1584,6596,Kit_W41,WT,-0.0296,2.8866358344881032e-05,0.0077939167531178785
+megakaryocyte,Basophil_mast,lineage,Voehringer-2013,,1584,6596,Kit_W41,WT,-0.0321,5.086605575626572e-22,1.3733835054191744e-19
+megakaryocyte,Hemostasis,signaling,Furie-2008,,1584,6596,Kit_W41,WT,0.0089,9.333990174953575e-55,2.520177347237465e-52
+megakaryocyte,OXPHOS_ETC,metabolism,Mishra-2016,,1584,6596,Kit_W41,WT,0.1004,3.532796721102679e-60,9.538551146977233e-58
+megakaryocyte,Glycolysis,metabolism,Vander-Heiden-2009,,1584,6596,Kit_W41,WT,0.0155,0.015714177308280924,1.0
+megakaryocyte,TCA,metabolism,Chandel-2015,,1584,6596,Kit_W41,WT,0.031,2.6008422291964864e-09,7.022274018830513e-07
+megakaryocyte,Redox_glutathione,stress,Ho-2007,,1584,6596,Kit_W41,WT,0.0567,2.549494835855986e-44,6.883636056811162e-42
+megakaryocyte,Wnt_hemato,signaling,Reya-2003,,1584,6596,Kit_W41,WT,-0.0039,0.026489096118498943,1.0
+megakaryocyte,Notch_hemato,signaling,Bigas-2018,,1584,6596,Kit_W41,WT,-0.0194,0.03088334945596802,1.0
+megakaryocyte,TGFb_hemato,signaling,Blank-2015,,1584,6596,Kit_W41,WT,-0.0107,0.007772468157700295,1.0
+megakaryocyte,IFN_signaling,immune,Essers-2009,,1584,6596,Kit_W41,WT,-0.0035,0.03485335055175709,1.0
+megakaryocyte,Complement,immune,Ricklin-2016,,1584,6596,Kit_W41,WT,0.0004,2.096383095085128e-13,5.6602343567298454e-11
+megakaryocyte,NK_cytotoxicity,immune,Vivier-2011,,1584,6596,Kit_W41,WT,0.0068,0.015262413340317664,1.0
+megakaryocyte,Mast_cell_degran,immune,Galli-2011,,1584,6596,Kit_W41,WT,-0.0402,1.1312884488753079e-29,3.0544788119633314e-27
+megakaryocyte,Autophagy,stress,Warr-2013,,1584,6596,Kit_W41,WT,-0.0089,0.32075263796584064,1.0
+megakaryocyte,Senescence,stress,Chang-2016,,1584,6596,Kit_W41,WT,-0.0271,7.847587085495174e-23,2.118848513083697e-20
+megakaryocyte,LT_HSC_quiescence,lineage,Cabezas-Wallscheid-2017,,1584,6596,Kit_W41,WT,-0.085,1.1982826756188524e-106,3.2353632241709014e-104
+monocyte,Kit_signaling,signaling,Lennartsson-2012,,157,315,Kit_W41,WT,-0.0755,0.00011118080582489278,0.03001881757272105
+monocyte,Kit_ligand,signaling,Broudy-1997,,157,315,Kit_W41,WT,-0.1267,0.01859535636479246,1.0
+monocyte,MYC_targets,lineage,Dang-2012,,157,315,Kit_W41,WT,-0.0315,0.03394125060915064,1.0
+monocyte,Cell_cycle,cycle,Whitfield-2002,,157,315,Kit_W41,WT,-0.0482,0.01467875345281262,1.0
+monocyte,DNA_replication,cycle,Bell-2002,,157,315,Kit_W41,WT,-0.0788,0.0015128851559343265,0.4084789921022681
+monocyte,Integrated_stress,stress,Pakos-Zebrucka-2016,,157,315,Kit_W41,WT,0.0317,0.0010341478066302427,0.27921990779016553
+monocyte,Apoptosis_pro,stress,Youle-2008,,157,315,Kit_W41,WT,-0.0221,0.26354934811682806,1.0
+monocyte,Apoptosis_anti,stress,Adams-2018,,157,315,Kit_W41,WT,0.0113,0.29076486958266,1.0
+monocyte,Erythropoiesis_early,lineage,Palis-2014,,157,315,Kit_W41,WT,0.0064,0.3521702290605,1.0
+monocyte,Erythropoiesis_late,lineage,Palis-2014,,157,315,Kit_W41,WT,0.0248,7.452790043961598e-07,0.00020122533118696313
+monocyte,Granulopoiesis,lineage,Rosenbauer-2007,,157,315,Kit_W41,WT,0.0093,0.5676236563284727,1.0
+monocyte,Lymphopoiesis_B,lineage,Nutt-2011,,157,315,Kit_W41,WT,0.0109,3.3807625369537226e-06,0.0009128058849775051
+monocyte,Lymphopoiesis_T,lineage,Rothenberg-2014,,157,315,Kit_W41,WT,0.0049,0.007390519434373717,1.0
+monocyte,Megakaryopoiesis,lineage,Tijssen-2013,,157,315,Kit_W41,WT,-0.0121,0.42535319410146355,1.0
+monocyte,Basophil_mast,lineage,Voehringer-2013,,157,315,Kit_W41,WT,0.0061,0.0003525218740393934,0.09518090599063621
+monocyte,Hemostasis,signaling,Furie-2008,,157,315,Kit_W41,WT,-0.0098,0.28010615093708624,1.0
+monocyte,OXPHOS_ETC,metabolism,Mishra-2016,,157,315,Kit_W41,WT,0.0232,0.22501497426865902,1.0
+monocyte,Glycolysis,metabolism,Vander-Heiden-2009,,157,315,Kit_W41,WT,0.0128,0.6590680970628982,1.0
+monocyte,TCA,metabolism,Chandel-2015,,157,315,Kit_W41,WT,0.047,0.006410958046092287,1.0
+monocyte,Redox_glutathione,stress,Ho-2007,,157,315,Kit_W41,WT,0.0275,0.025629161154232187,1.0
+monocyte,Wnt_hemato,signaling,Reya-2003,,157,315,Kit_W41,WT,-0.0027,0.6627014057394787,1.0
+monocyte,Notch_hemato,signaling,Bigas-2018,,157,315,Kit_W41,WT,0.0032,0.1970723654588994,1.0
+monocyte,TGFb_hemato,signaling,Blank-2015,,157,315,Kit_W41,WT,0.0116,0.2993524180888183,1.0
+monocyte,IFN_signaling,immune,Essers-2009,,157,315,Kit_W41,WT,-0.0007,0.802060048411065,1.0
+monocyte,Complement,immune,Ricklin-2016,,157,315,Kit_W41,WT,-0.0131,0.7261597611990066,1.0
+monocyte,NK_cytotoxicity,immune,Vivier-2011,,157,315,Kit_W41,WT,0.0068,0.32085599894727923,1.0
+monocyte,Mast_cell_degran,immune,Galli-2011,,157,315,Kit_W41,WT,-0.0302,0.16165671911231239,1.0
+monocyte,Autophagy,stress,Warr-2013,,157,315,Kit_W41,WT,0.0166,0.17583775410041802,1.0
+monocyte,Senescence,stress,Chang-2016,,157,315,Kit_W41,WT,-0.0157,0.07176400231508503,1.0
+monocyte,LT_HSC_quiescence,lineage,Cabezas-Wallscheid-2017,,157,315,Kit_W41,WT,-0.0057,0.013179343389636528,1.0
+myeloid,Kit_signaling,signaling,Lennartsson-2012,,1708,1755,Kit_W41,WT,-0.093,8.939099940799535e-56,2.4135569840158745e-53
+myeloid,Kit_ligand,signaling,Broudy-1997,,1708,1755,Kit_W41,WT,-0.1517,2.2077104497064844e-56,5.960818214207508e-54
+myeloid,MYC_targets,lineage,Dang-2012,,1708,1755,Kit_W41,WT,-0.0618,4.050309042746275e-28,1.0935834415414942e-25
+myeloid,Cell_cycle,cycle,Whitfield-2002,,1708,1755,Kit_W41,WT,-0.0454,1.8160205318044215e-12,4.903255435871938e-10
+myeloid,DNA_replication,cycle,Bell-2002,,1708,1755,Kit_W41,WT,-0.0947,3.091363851621243e-43,8.346682399377355e-41
+myeloid,Integrated_stress,stress,Pakos-Zebrucka-2016,,1708,1755,Kit_W41,WT,0.0345,6.882346666938825e-28,1.8582336000734827e-25
+myeloid,Apoptosis_pro,stress,Youle-2008,,1708,1755,Kit_W41,WT,0.0247,5.334176858829963e-07,0.000144022775188409
+myeloid,Apoptosis_anti,stress,Adams-2018,,1708,1755,Kit_W41,WT,-0.0208,3.2054191402810595e-05,0.008654631678758861
+myeloid,Erythropoiesis_early,lineage,Palis-2014,,1708,1755,Kit_W41,WT,0.024,3.3169008799535752e-18,8.955632375874653e-16
+myeloid,Erythropoiesis_late,lineage,Palis-2014,,1708,1755,Kit_W41,WT,0.0327,1.0345348148001514e-57,2.7932439999604087e-55
+myeloid,Granulopoiesis,lineage,Rosenbauer-2007,,1708,1755,Kit_W41,WT,0.0704,2.862351472324e-14,7.7283489752748e-12
+myeloid,Lymphopoiesis_B,lineage,Nutt-2011,,1708,1755,Kit_W41,WT,0.0008,2.533483661672081e-10,6.840405886514618e-08
+myeloid,Lymphopoiesis_T,lineage,Rothenberg-2014,,1708,1755,Kit_W41,WT,0.0007,3.5646043820037825e-07,9.624431831410212e-05
+myeloid,Megakaryopoiesis,lineage,Tijssen-2013,,1708,1755,Kit_W41,WT,-0.001,0.7025455728454622,1.0
+myeloid,Basophil_mast,lineage,Voehringer-2013,,1708,1755,Kit_W41,WT,-0.0008,0.00026588046784988386,0.07178772631946864
+myeloid,Hemostasis,signaling,Furie-2008,,1708,1755,Kit_W41,WT,0.0056,4.1605670449550576e-10,1.1233531021378656e-07
+myeloid,OXPHOS_ETC,metabolism,Mishra-2016,,1708,1755,Kit_W41,WT,-0.0081,0.05169422544038418,1.0
+myeloid,Glycolysis,metabolism,Vander-Heiden-2009,,1708,1755,Kit_W41,WT,0.0732,9.487440007056612e-53,2.5616088019052855e-50
+myeloid,TCA,metabolism,Chandel-2015,,1708,1755,Kit_W41,WT,0.0714,1.0949190745077111e-39,2.95628150117082e-37
+myeloid,Redox_glutathione,stress,Ho-2007,,1708,1755,Kit_W41,WT,0.0259,5.01153589645176e-12,1.353114692041975e-09
+myeloid,Wnt_hemato,signaling,Reya-2003,,1708,1755,Kit_W41,WT,-0.0053,0.39573986404851846,1.0
+myeloid,Notch_hemato,signaling,Bigas-2018,,1708,1755,Kit_W41,WT,-0.0148,0.03690287363693328,1.0
+myeloid,TGFb_hemato,signaling,Blank-2015,,1708,1755,Kit_W41,WT,0.0095,1.6986996790374525e-05,0.004586489133401122
+myeloid,IFN_signaling,immune,Essers-2009,,1708,1755,Kit_W41,WT,-0.0023,0.055085254690698034,1.0
+myeloid,Complement,immune,Ricklin-2016,,1708,1755,Kit_W41,WT,0.0061,2.362407333829985e-22,6.37849980134096e-20
+myeloid,NK_cytotoxicity,immune,Vivier-2011,,1708,1755,Kit_W41,WT,0.0273,2.6115123614819167e-16,7.051083376001175e-14
+myeloid,Mast_cell_degran,immune,Galli-2011,,1708,1755,Kit_W41,WT,-0.0546,3.559665090106834e-22,9.611095743288452e-20
+myeloid,Autophagy,stress,Warr-2013,,1708,1755,Kit_W41,WT,0.0129,0.0004269321699905454,0.11527168589744725
+myeloid,Senescence,stress,Chang-2016,,1708,1755,Kit_W41,WT,-0.007,0.022974270023396876,1.0
+myeloid,LT_HSC_quiescence,lineage,Cabezas-Wallscheid-2017,,1708,1755,Kit_W41,WT,-0.0023,7.826709545417907e-07,0.00021132115772628347

discovery/hematopoiesis/marker/57_pathway_class_by_module_delta.tsv

@@ -0,0 +1,31 @@
+module_name	LT-HSC	MPP	basophil-mast	erythroid	lymphoid	macrophage	megakaryocyte	monocyte	myeloid
+Apoptosis_anti	0.018	-0.0378	-0.0277	-0.0184	-0.036	0.0507	-0.0587	0.0113	-0.0208
+Apoptosis_pro	0.0375	0.0674	0.0125	-0.0173	0.0957	0.0559	0.0344	-0.0221	0.0247
+Autophagy	0.0507	-0.0033	0.0225	-0.0233	0.0002	-0.012	-0.0089	0.0166	0.0129
+Basophil_mast	0.0009	0.05	-0.0282	-0.0492	0.0041	-0.0041	-0.0321	0.0061	-0.0008
+Cell_cycle	0.0598	0.029	-0.0678	0.022	0.0563	0.0283	-0.0567	-0.0482	-0.0454
+Complement	0.0228	0.0047	-0.0022	-0.0	0.0035	0.0027	0.0004	-0.0131	0.0061
+DNA_replication	0.0103	-0.0143	-0.0791	-0.0583	0.0649	-0.0104	-0.0943	-0.0788	-0.0947
+Erythropoiesis_early	-0.0839	-0.0197	0.016	-0.0407	-0.0124	-0.0183	-0.0007	0.0064	0.024
+Erythropoiesis_late	0.0682	0.0396	0.037	0.0423	0.0144	0.0478	0.0474	0.0248	0.0327
+Glycolysis	0.0237	0.063	0.0575	0.0508	0.0388	0.1901	0.0155	0.0128	0.0732
+Granulopoiesis	0.2185	0.2763	0.1481	0.0828	0.0925	0.2101	0.0808	0.0093	0.0704
+Hemostasis	0.0072	0.007	0.0012	0.0022	0.0028	0.0505	0.0089	-0.0098	0.0056
+IFN_signaling	-0.0717	-0.0173	-0.0039	-0.0058	-0.0227	-0.0271	-0.0035	-0.0007	-0.0023
+Integrated_stress	0.0564	0.0208	0.0323	0.0191	-0.0025	0.0576	0.0188	0.0317	0.0345
+Kit_ligand	-0.3438	-0.2744	-0.2422	-0.2158	-0.3338	-0.1218	-0.2031	-0.1267	-0.1517
+Kit_signaling	-0.4509	-0.2712	-0.2462	-0.243	-0.2701	-0.1449	-0.265	-0.0755	-0.093
+LT_HSC_quiescence	-0.2871	-0.154	-0.032	-0.0176	-0.128	-0.0121	-0.085	-0.0057	-0.0023
+Lymphopoiesis_B	0.0385	0.0076	0.0022	0.0021	0.0383	0.0	0.0013	0.0109	0.0008
+Lymphopoiesis_T	-0.0118	-0.0013	-0.0086	0.0001	0.076	-0.0088	-0.0126	0.0049	0.0007
+MYC_targets	-0.0609	-0.0041	-0.0712	-0.0059	0.0993	0.1441	0.0518	-0.0315	-0.0618
+Mast_cell_degran	-0.0504	-0.0269	-0.0575	-0.0542	-0.0594	-0.0253	-0.0402	-0.0302	-0.0546
+Megakaryopoiesis	-0.0465	-0.0304	-0.0435	-0.0329	-0.0057	-0.0068	-0.0296	-0.0121	-0.001
+NK_cytotoxicity	0.0178	0.0268	0.0036	-0.0176	0.1258	-0.012	0.0068	0.0068	0.0273
+Notch_hemato	-0.0212	-0.0212	-0.0244	-0.0192	0.008	-0.0045	-0.0194	0.0032	-0.0148
+OXPHOS_ETC	0.2189	0.1381	-0.036	0.1154	0.1961	0.0436	0.1004	0.0232	-0.0081
+Redox_glutathione	0.0579	0.0588	0.0373	0.0721	0.0946	0.0985	0.0567	0.0275	0.0259
+Senescence	0.0414	0.0035	-0.0171	-0.0398	0.0551	-0.0287	-0.0271	-0.0157	-0.007
+TCA	0.0042	0.0549	0.0495	0.0143	0.0745	0.0625	0.031	0.047	0.0714
+TGFb_hemato	-0.0069	0.0005	-0.0026	-0.0419	0.0115	-0.0567	-0.0107	0.0116	0.0095
+Wnt_hemato	-0.0238	-0.0031	0.0044	-0.0115	0.0264	-0.0109	-0.0039	-0.0027	-0.0053

discovery/hematopoiesis/marker/57_pathway_class_by_module_padj.tsv

@@ -0,0 +1,31 @@
+module_name	LT-HSC	MPP	basophil-mast	erythroid	lymphoid	macrophage	megakaryocyte	monocyte	myeloid
+Apoptosis_anti	1.0	3.961885101115953e-36	1.0	0.0033176124389026765	1.0	1.0	5.8239939253090815e-34	1.0	0.008654631678758861
+Apoptosis_pro	1.0	5.200327084354871e-125	1.0	2.2549023082556283e-13	0.05866380657366192	1.0	6.237070809572251e-12	1.0	0.000144022775188409
+Autophagy	1.0	1.0	1.0	2.0537441485759147e-20	1.0	1.0	1.0	1.0	0.11527168589744725
+Basophil_mast	1.0	1.6978271240978898e-143	1.0	5.6402375280060556e-98	1.0	1.0	1.3733835054191744e-19	0.09518090599063621	0.07178772631946864
+Cell_cycle	1.0	2.082143244417133e-17	0.2865568397620519	1.0	1.0	1.0	7.452863286284741e-10	1.0	4.903255435871938e-10
+Complement	1.0	5.508051193861285e-178	1.0	5.266475417105462e-10	0.07155400688580271	1.0	5.6602343567298454e-11	1.0	6.37849980134096e-20
+DNA_replication	1.0	1.0	0.3178290860590987	5.944729767806566e-72	0.37875157222579564	1.0	6.5895508956573805e-25	0.4084789921022681	8.346682399377355e-41
+Erythropoiesis_early	1.0	2.6156057282553174e-26	1.0	4.949450747731663e-53	1.0	1.0	1.0	1.0	8.955632375874653e-16
+Erythropoiesis_late	1.0	8.995045341862003e-287	4.898551174951897e-06	1.54691208840116e-166	0.01625247998680913	1.0	3.233249150432994e-54	0.00020122533118696313	2.7932439999604087e-55
+Glycolysis	1.0	7.418835701879237e-66	0.11056861314089872	4.001684413925927e-95	1.0	0.5796011859746667	1.0	1.0	2.5616088019052855e-50
+Granulopoiesis	0.06664628736612163	0.0	0.0005998283710565132	0.0	0.0005643438111287908	1.0	2.904328188935755e-135	1.0	7.7283489752748e-12
+Hemostasis	1.0	2.0485880944367307e-176	1.0	1.2291799378102821e-166	1.0	1.0	2.520177347237465e-52	1.0	1.1233531021378656e-07
+IFN_signaling	1.0	1.0	1.0	0.047932348545608724	1.0	1.0	1.0	1.0	1.0
+Integrated_stress	1.0	1.3561508395174703e-28	0.17851048066832573	5.194545925055892e-43	1.0	1.0	1.6648209939285727e-06	0.27921990779016553	1.8582336000734827e-25
+Kit_ligand	0.0015217229263033102	0.0	1.2648461782646388e-13	0.0	1.4696060305328676e-09	1.0	1.1061094107573234e-62	1.0	5.960818214207508e-54
+Kit_signaling	4.248284612676681e-06	0.0	3.5136729359202435e-20	0.0	6.546606916824804e-06	1.0	1.0521749419177073e-207	0.03001881757272105	2.4135569840158745e-53
+LT_HSC_quiescence	0.0015560007612659547	0.0	1.0	1.4698987953797095e-26	0.8119976649934685	1.0	3.2353632241709014e-104	1.0	0.00021132115772628347
+Lymphopoiesis_B	1.0	1.1002232618937107e-68	1.0	5.581025489924339e-107	1.0	0.31810267374134743	5.56331937664189e-39	0.0009128058849775051	6.840405886514618e-08
+Lymphopoiesis_T	1.0	0.015839093537470463	1.0	2.878994049195316e-27	0.6586265575785515	1.0	0.019331699615077063	1.0	9.624431831410212e-05
+MYC_targets	1.0	1.0	0.016990529978692725	3.880361986724347e-14	1.0	1.0	1.2616767874254019e-11	1.0	1.0935834415414942e-25
+Mast_cell_degran	1.0	2.0689796940119147e-52	1.0	0.0	0.06477398285483997	1.0	3.0544788119633314e-27	1.0	9.611095743288452e-20
+Megakaryopoiesis	1.0	2.1291851280001707e-30	0.037366786493932304	1.941364709705936e-37	1.0	1.0	0.0077939167531178785	1.0	1.0
+NK_cytotoxicity	1.0	2.1243096746462854e-73	0.27275984666310815	0.3277108210772517	0.019985112798184455	1.0	1.0	1.0	7.051083376001175e-14
+Notch_hemato	1.0	1.0	1.0	1.6969654391715552e-07	1.0	1.0	1.0	1.0	1.0
+OXPHOS_ETC	0.02493169037521065	4.534536182433296e-265	1.0	6.795417502923138e-256	2.3010335201204353e-05	1.0	9.538551146977233e-58	1.0	1.0
+Redox_glutathione	1.0	1.2231948939418045e-127	0.600679659889748	1.0500155234634517e-232	0.04342167987420725	1.0	6.883636056811162e-42	1.0	1.353114692041975e-09
+Senescence	1.0	1.0	1.0	9.899605745957913e-262	0.1683484048086048	1.0	2.118848513083697e-20	1.0	1.0
+TCA	1.0	1.1518265935460723e-65	0.029336646870005534	0.06726261342243191	1.0	1.0	7.022274018830513e-07	1.0	2.95628150117082e-37
+TGFb_hemato	1.0	1.0	1.0	6.181637421756523e-106	1.0	1.0	1.0	1.0	0.004586489133401122
+Wnt_hemato	1.0	0.0008142674989191102	0.058501895249731206	7.336165744832385e-11	1.0	1.0	1.0	1.0	1.0

discovery/hematopoiesis/marker/92_dahlin_marker_deep_dive.csv

@@ -0,0 +1,11 @@
+predicted_class,n_cells,top_wilcoxon_markers,min_p_adj_top5,best_canonical_panel_match,recovery,n_WT,n_Kit_W41,frac_WT
+MPP,31754,"Cd34(LFC+3.4),Macroh2a1(LFC+2.2),Adgrl4(LFC+3.3),Sox4(LFC+2.2),Pim1(LFC+2.5),Coro1a(LFC+1.9),Lcp1(LFC+2.4),Tmem176b(LFC+1.9),mt-Co1(LFC+0.6),Cd27(LFC+2.3)",0.0,Kit-signaling,1/3: Sox4,27931,3823,0.8796057189645399
+erythroid,15397,"Ca1(LFC+5.6),Blvrb(LFC+4.0),Klf1(LFC+4.6),Aqp1(LFC+4.0),Atp5if1(LFC+1.3),Mt1(LFC+4.1),Tspo2(LFC+4.8),Ces2g(LFC+4.5),Hdgf(LFC+1.5),Ntrn4it1(LFC+4.0)",0.0,erythroid,"2/7: Klf1,Blvrb",8352,7045,0.5424433331168409
+megakaryocyte,8180,"Apoe(LFC+2.8),Itga2b(LFC+3.4),Pbx1(LFC+2.8),Cd9(LFC+2.2),Fermt3(LFC+1.2),Tgfb1(LFC+1.0),Gata2(LFC+1.8),Nrgn(LFC+1.8),F2r(LFC+2.8),Mef2c(LFC+1.3)",0.0,megakaryocyte,"2/4: Itga2b,Pf4",6596,1584,0.8063569682151589
+myeloid,3463,"Ctsg(LFC+5.4),Mpo(LFC+4.7),Prtn3(LFC+3.6),Elane(LFC+6.6),Plac8(LFC+2.6),Calr(LFC+1.8),Hp(LFC+5.3),Sec61b(LFC+1.4),Ap3s1(LFC+2.5),Clec12a(LFC+3.6)",0.0,myeloid,"4/8: Elane,Mpo,Prtn3,Ctsg",1755,1708,0.5067860236788911
+basophil-mast,848,"Cpa3(LFC+5.6),Lmo4(LFC+4.7),Ms4a2(LFC+7.2),Csrp3(LFC+5.3),Cd63(LFC+3.0),Srgn(LFC+1.5),Plac8(LFC+2.3),Ly6e(LFC+1.8),Lgals1(LFC+3.2),Hdc(LFC+4.7)",0.0,basophil-mast,"4/5: Cpa3,Ms4a2,Gata2,Hdc",603,245,0.7110849056603774
+lymphoid,694,"Malat1(LFC+1.4),mt-Co1(LFC+0.6),Rps27(LFC+0.5),Gimap1(LFC+1.9),B2m(LFC+0.5),Gimap6(LFC+2.1),Ptprcap(LFC+1.0),H2-D1(LFC+0.6),Myl10(LFC+2.2),Shisa5(LFC+1.8)",1.1145785854068545e-200,LT-HSC,0/7: ,639,55,0.920749279538905
+monocyte,472,"Irf8(LFC+4.2),Ms4a6c(LFC+4.3),Tyrobp(LFC+3.6),Lgals1(LFC+3.4),Cst3(LFC+2.0),Clec12a(LFC+3.3),Tmsb4x(LFC+2.1),Fcer1g(LFC+3.0),Plac8(LFC+2.1),Tspo(LFC+1.4)",2.3630087037973703e-225,myeloid,"2/8: Mpo,Ctsg",315,157,0.6673728813559322
+LT-HSC,160,"Malat1(LFC+1.0),Mpl(LFC+2.6),Ifitm1(LFC+1.5),Shisa5(LFC+1.6),mt-Co1(LFC+0.4),Hlf(LFC+1.7),Lyz2(LFC+1.2),Tmem176b(LFC+1.1),B2m(LFC+0.5),Gimap1(LFC+1.5)",3.033195500357888e-23,LT-HSC,"3/7: Hlf,Meis1,Mecom",135,25,0.84375
+pro-B,66,"Ebf1(LFC+12.1),Cd79a(LFC+11.2),Vpreb3(LFC+12.6),Chchd10(LFC+4.1),Cd79b(LFC+4.7),Tifa(LFC+4.3),Mzb1(LFC+10.5),Cd24a(LFC+2.7),Ucp2(LFC+2.3),Pkig(LFC+2.6)",3.0885880974286854e-33,lymphoid,1/4: Il7r,60,6,0.9090909090909091
+macrophage,63,"Irf8(LFC+5.0),Lgals1(LFC+3.6),Tyrobp(LFC+3.5),Ms4a6c(LFC+3.7),Unc93b1(LFC+3.1),Plac8(LFC+2.2),Cst3(LFC+1.5),Tmsb10(LFC+1.3),Clec12a(LFC+3.2),BC035044(LFC+2.4)",5.2013797463400565e-33,myeloid,1/8: Ctsg,42,21,0.6666666666666666