# Pan-Pancreas PANDA

Multi-dataset corpus for pancreas cell identity + zero-shot transfer + mechanistic discovery.

## Corpus datasets

| Accession | Study | Cells | Species | Modality | Role |
|---|---|---:|---|---|---|
| GSE132188 | Bastidas-Ponce 2019 | 33,896 | mouse | 10x v2 | Anchor E15.5 endocrine progenitor time course (local) |
| GSE84133 | Baron 2016 | ~10,000 | mouse+human | inDrops | Adult islet reference |
| GSE85241 | Muraro 2016 | ~2,126 | human | CEL-Seq2 | Deep-coverage adult islet |
| E-MTAB-5061 | Segerstolpe 2016 | ~3,514 | human | Smart-seq2 | Deep + T2D covariate |
| GSE81076 | Grun 2016 | ~1,595 | human | CEL-Seq | Modality diversity |
| GSE101099 | Byrnes 2018 | ~12,000 | mouse | inDrops | Independent-lab time course |

## Held-out labeled validation

**Baron 2016 mouse subset** — has full canonical islet labels (alpha/beta/delta/gamma/epsilon/
ductal/acinar/endothelial/immune) but is a completely independent scRNA-seq study from a
different lab. Zero-shot transfer of PANDA-pancreas predictions to Baron gives an
apples-to-apples accuracy measurement across labs.

## Held-out unlabeled discovery target

**Veres 2019 hPSC-directed differentiation (GSE114412)** — human pluripotent stem cell
differentiation to SC-beta cells with an off-target enterochromaffin population. Weakly
labeled by day-of-differentiation only; PANDA's cell-type predictions become hypothesis-
generating annotations.

## Ontology (11 classes)

- alpha
- beta
- delta
- gamma (PP)
- epsilon
- endocrine-progenitor
- ductal
- acinar
- endothelial
- immune
- other/mesenchymal