Buckets:
| [ | |
| { | |
| "pool": "nhanes_age_pairwise", | |
| "display_name": "NHANES Age / Pairwise", | |
| "domain": "clinical", | |
| "lb_code": "LB-0034", | |
| "prompt": "Which participant is older, based on their clinical blood test results? Answer with one letter.\n\nOptions: A. Participant A B. Participant B\n\nParticipant A:\nDemographic information: Female.\nBody measurements: BMI 24.4 kg/m2.\nBlood panel: Albumin (g/dL) 4.20; Alkaline phosphatase (U/L) 101.00; Blood urea nitrogen (mg/dL) 21.00; Creatinine (umol/L) 75.68; Serum glucose (mmol/L) 4.88; Total bilirubin (mg/dL) 0.50; Uric acid (mg/dL) 5.20; Total cholesterol (mg/dL) 253.00; HDL (mg/dL) 47.00; LDL (mg/dL) 170.00; Triglyceride (mg/dL) 178.00; C-reactive protein (mg/dL) 0.17; Cystatin C (mg/L) 1.19; White blood cell count (1000 cells/uL) 5.80; Red blood cell count (million cells/uL) 4.86; Mean cell volume (fL) 88.80; Red cell distribution width (%) 11.90; Segmented neutrophils percent (%) 65.90; Lymphocyte percent (%) 24.20; Monocyte percent (%) 6.80; Eosinophils percent (%) 2.50; Basophils percent (%) 0.60; Glycohemoglobin (%) 4.80; Vitamin A (umol/L) 1.88; Vitamin E (umol/L) 62.04; Vitamin B12 (pmol/L) 706.27; Bone alkaline phosphatase (ug/L) 21.09; Cadmium (nmol/L) 3.56.\n\nParticipant B:\nDemographic information: Female.\nBiometrics: BMI 24.7 kg/m2.\nBlood test results: Albumin (g/L) 41.00; Alkaline phosphatase (U/L) 80.00; Blood urea nitrogen (mg/dL) 14.00; Creatinine (mg/dL) 0.75; Serum glucose (mg/dL) 85.00; Total bilirubin (mg/dL) 0.40; Uric acid (mg/dL) 6.30; Total cholesterol (mg/dL) 181.00; HDL (mg/dL) 62.00; LDL (mg/dL) 100.00; Triglyceride (mg/dL) 93.00; C-reactive protein (mg/dL) 0.21; White blood cell count (1000 cells/uL) 5.60; Red blood cell count (million cells/uL) 4.03; Mean cell volume (fL) 90.60; Red cell distribution width (%) 12.90; Segmented neutrophils percent (%) 41.80; Lymphocyte percent (%) 41.70; Monocyte percent (%) 14.00; Eosinophils percent (%) 2.00; Basophils percent (%) 0.60; Glycohemoglobin (%) 5.40; Vitamin A (umol/L) 2.10; Vitamin E (umol/L) 22.12; Vitamin B12 (pmol/L) 425.09; Bone alkaline phosphatase (ug/L) 13.33; Cadmium (nmol/L) 6.23.", | |
| "answer": "A", | |
| "ground_truth_note": "Participant A (SEQN 7657): 66 years old. Participant B (SEQN 5868): 47 years old." | |
| }, | |
| { | |
| "pool": "nhanes_age_multiclass", | |
| "display_name": "NHANES Age / Multiclass", | |
| "domain": "clinical", | |
| "lb_code": "LB-0030", | |
| "prompt": "What is this participant's age group?\n\nOptions: A. 30-45 B. 75+ C. 60-75 D. 18-30 E. 45-60\n\nPatient data:\nDemographics: Female.\nBody measurements: BMI 22.3 kg/m2.\nBlood panel: Albumin (g/dL) 4.50; Alkaline phosphatase (U/L) 67.00; Blood urea nitrogen (mg/dL) 17.00; Creatinine (umol/L) 66.73; Serum glucose (mmol/L) 2.61; Total bilirubin (mg/dL) 0.40; Uric acid (mg/dL) 5.00; Total cholesterol (mg/dL) 203.00; HDL (mg/dL) 53.00; C-reactive protein (mg/dL) 0.16; White blood cell count (1000 cells/uL) 8.70; Red blood cell count (million cells/uL) 5.45; Mean cell volume (fL) 89.60; Red cell distribution width (%) 12.10; Segmented neutrophils percent (%) 48.50; Lymphocyte percent (%) 40.20; Monocyte percent (%) 6.70; Eosinophils percent (%) 3.70; Basophils percent (%) 0.90; Glycohemoglobin (%) 7.70; Vitamin A (umol/L) 2.28; Vitamin E (umol/L) 22.62; Vitamin B12 (pmol/L) 3015.47; Bone alkaline phosphatase (ug/L) 15.24; Cadmium (nmol/L) 10.68.", | |
| "answer": "E", | |
| "ground_truth_note": "SEQN 4990: 56 years old." | |
| }, | |
| { | |
| "pool": "nhanes_age_regression", | |
| "display_name": "NHANES Age / Regression", | |
| "domain": "clinical", | |
| "lb_code": "LB-0038", | |
| "prompt": "How old is this participant? Answer in years.\n\nClinical profile:\nDemographic information: Female.\nBody measurements: BMI 22.3 kg/m2.\nBlood panel: Albumin (g/dL) 4.50; Alkaline phosphatase (U/L) 67.00; Blood urea nitrogen (mg/dL) 17.00; Creatinine (umol/L) 66.73; Serum glucose (mmol/L) 2.61; Total bilirubin (mg/dL) 0.40; Uric acid (mg/dL) 5.00; Total cholesterol (mg/dL) 203.00; HDL (mg/dL) 53.00; C-reactive protein (mg/dL) 0.16; White blood cell count (1000 cells/uL) 8.70; Red blood cell count (million cells/uL) 5.45; Mean cell volume (fL) 89.60; Red cell distribution width (%) 12.10; Segmented neutrophils percent (%) 48.50; Lymphocyte percent (%) 40.20; Monocyte percent (%) 6.70; Eosinophils percent (%) 3.70; Basophils percent (%) 0.90; Glycohemoglobin (%) 7.70; Vitamin A (umol/L) 2.28; Vitamin E (umol/L) 22.62; Vitamin B12 (pmol/L) 3015.47; Bone alkaline phosphatase (ug/L) 15.24; Cadmium (nmol/L) 10.68.", | |
| "answer": "56", | |
| "ground_truth_note": "SEQN 4990: 56 years old." | |
| }, | |
| { | |
| "pool": "nhanes_mortality_binary", | |
| "display_name": "NHANES Mortality / Binary", | |
| "domain": "clinical", | |
| "lb_code": "LB-0042", | |
| "prompt": "Did this participant survive 10 years post-examination?\n\nOptions: A. No B. Yes\n\nClinical profile:\nDemographics: 71-year-old female with 9-11th grade of other ethnicity.\nBiometrics: BMI 26.4 kg/m2, height 148.3 cm, waist circumference 91.7 cm, body weight 58.1 kg, systolic blood pressure 151.3 mm Hg.\nBlood panel: Albumin (g/L) 47.00; Alkaline phosphatase (U/L) 53.00; Blood urea nitrogen (mg/dL) 17.00; Creatinine (umol/L) 111.50; Serum glucose (mg/dL) 144.00; Total bilirubin (mg/dL) 0.40; Uric acid (mg/dL) 8.00; Total cholesterol (mg/dL) 229.00; HDL (mg/dL) 36.00; C-reactive protein (mg/dL) 0.08; Cystatin C (mg/L) 1.09; White blood cell count (1000 cells/uL) 8.10; Red blood cell count (million cells/uL) 4.59; Mean cell volume (fL) 96.60; Red cell distribution width (%) 12.40; Segmented neutrophils percent (%) 44.30; Lymphocyte percent (%) 43.50; Monocyte percent (%) 11.20; Eosinophils percent (%) 0.80; Basophils percent (%) 0.20; Glycohemoglobin (%) 9.50; Vitamin A (umol/L) 1.81; Vitamin E (umol/L) 24.69; Vitamin B12 (pmol/L) 326.93; Bone alkaline phosphatase (ug/L) 9.61; Cadmium (nmol/L) 9.79.\nMedications: Acarbose (taken for 6 months), Amitriptyline (taken for 5 years), Amylase; Lipase; Protease (taken for 6 months), Cisapride (taken for 6 months), Insulin (taken for 6 years), Insulin (taken for 6 years), Simvastatin (taken for 12 months).\nSelf-reported data: Has medical history of diabetes (taking diabetes pills); arthritis. Family history of diabetes, osteoporosis. Reproductive history: has been pregnant; first period at age 15; last period at age 42.", | |
| "answer": "B", | |
| "ground_truth_note": "SEQN 9370: Deceased at 18 years 3 months, cause: diabetes" | |
| }, | |
| { | |
| "pool": "nhanes_mortality_pairwise", | |
| "display_name": "NHANES Mortality / Pairwise", | |
| "domain": "clinical", | |
| "lb_code": "LB-0050", | |
| "prompt": "Which participant had longer survival after examination?\n\nOptions: A. Participant A B. Participant B\n\nParticipant A:\nDemographics: 76-year-old male with less than 9th grade of Mexican American ethnicity.\nBody measurements: BMI 24.8 kg/m2, height 166.3 cm, waist circumference 102.7 cm, body weight 68.7 kg, diastolic blood pressure 67.3 mm Hg, systolic blood pressure 144.0 mm Hg, pulse 76.7 bpm.\nBlood panel: Albumin (g/L) 41.00; Alkaline phosphatase (U/L) 96.00; Blood urea nitrogen (mg/dL) 18.00; Creatinine (mg/dL) 1.06; Serum glucose (mg/dL) 153.00; Total bilirubin (mg/dL) 0.40; Uric acid (mg/dL) 5.00; Total cholesterol (mg/dL) 202.00; HDL (mg/dL) 35.00; C-reactive protein (mg/dL) 0.18; Cystatin C (mg/L) 1.13; White blood cell count (1000 cells/uL) 8.60; Red blood cell count (million cells/uL) 4.31; Mean cell volume (fL) 91.60; Red cell distribution width (%) 13.20; Segmented neutrophils percent (%) 59.60; Lymphocyte percent (%) 26.20; Monocyte percent (%) 8.50; Eosinophils percent (%) 4.90; Basophils percent (%) 0.80; Glycohemoglobin (%) 11.10; Vitamin A (umol/L) 1.75; Vitamin E (umol/L) 16.28; Vitamin B12 (pmol/L) 228.78; Bone alkaline phosphatase (ug/L) 10.93; Cadmium (nmol/L) 4.45.\nMedications: Glyburide (taken for 2 years), Metformin (taken for 2 years).\nSelf-reported data: Has medical history of diabetes (taking diabetes pills). Family history of diabetes.\n\nParticipant B:\nDemographics: 74-year-old female with 9-11th grade of non-Hispanic black ethnicity.\nBiometrics: BMI 29.9 kg/m2, height 163.6 cm, waist circumference 96.2 cm, body weight 80.1 kg, diastolic blood pressure 60.7 mm Hg, systolic blood pressure 106.7 mm Hg, pulse 46.0 bpm.\nBlood panel: Albumin (g/L) 43.00; Alkaline phosphatase (U/L) 66.00; Blood urea nitrogen (mg/dL) 16.00; Creatinine (mg/dL) 0.86; Serum glucose (mg/dL) 99.00; Total bilirubin (mg/dL) 0.50; Uric acid (mg/dL) 6.80; Total cholesterol (mg/dL) 221.00; HDL (mg/dL) 62.00; C-reactive protein (mg/dL) 0.14; Cystatin C (mg/L) 0.96; White blood cell count (1000 cells/uL) 5.60; Red blood cell count (million cells/uL) 3.72; Mean cell volume (fL) 99.30; Red cell distribution width (%) 11.70; Segmented neutrophils percent (%) 52.50; Lymphocyte percent (%) 33.60; Monocyte percent (%) 8.70; Eosinophils percent (%) 4.00; Basophils percent (%) 1.30; Glycohemoglobin (%) 5.40; Vitamin A (umol/L) 1.83; Vitamin E (umol/L) 30.57; Vitamin B12 (pmol/L) 532.10; Bone alkaline phosphatase (ug/L) 12.62; Cadmium (nmol/L) 5.34.\nMedications: Fexofenadine (taken for 12 months), Levothyroxine (taken for 2 years).\nSelf-reported data: Has medical history of thyroid problem (still has thyroid problem); asthma. Family history of Alzheimer's disease, arthritis. Engages in moderate home or yard tasks. Reproductive history: has been pregnant; had hysterectomy at age 26; had one ovary removed; first period at age 12.", | |
| "answer": "B", | |
| "ground_truth_note": "Participant A (SEQN 3506): Deceased at 6 years 7 months, cause: cerebrovascular diseases. Participant B (SEQN 3296): Deceased at 14 years 6 months, cause: cancer" | |
| }, | |
| { | |
| "pool": "nhanes_mortality_multiclass", | |
| "display_name": "NHANES Mortality / Multiclass", | |
| "domain": "clinical", | |
| "lb_code": "LB-0046", | |
| "prompt": "How long did this participant survive post-examination?\n\nOptions: A. 0-5 years B. 15+ years C. 5-10 years D. 10-15 years\n\nClinical profile:\nDemographic information: 54-year-old female with less than 9th grade of Mexican American ethnicity.\nBody measurements: BMI 26.5 kg/m2, height 166.6 cm, waist circumference 97.0 cm, body weight 73.5 kg, diastolic blood pressure 70.7 mm Hg, systolic blood pressure 110.7 mm Hg, pulse 40.0 bpm.\nBlood panel: Albumin (g/dL) 4.50; Alkaline phosphatase (U/L) 90.00; Blood urea nitrogen (mg/dL) 19.00; Creatinine (mg/dL) 0.65; Serum glucose (mmol/L) 4.83; Total bilirubin (mg/dL) 0.60; Uric acid (mg/dL) 5.10; Total cholesterol (mg/dL) 245.00; HDL (mg/dL) 45.00; LDL (mg/dL) 166.00; Triglyceride (mg/dL) 171.00; C-reactive protein (mg/dL) 0.62; Cystatin C (mg/L) 0.80; White blood cell count (1000 cells/uL) 6.40; Red blood cell count (million cells/uL) 4.30; Mean cell volume (fL) 93.40; Red cell distribution width (%) 12.30; Segmented neutrophils percent (%) 46.30; Lymphocyte percent (%) 41.20; Monocyte percent (%) 10.00; Eosinophils percent (%) 1.80; Basophils percent (%) 0.70; Glycohemoglobin (%) 5.10; Vitamin A (umol/L) 2.47; Vitamin E (umol/L) 35.27; Vitamin B12 (pmol/L) 223.61; Bone alkaline phosphatase (ug/L) 15.05; Cadmium (nmol/L) 13.35.\nMedications: Beclomethasone Nasal (taken for 5 years), Cetirizine (taken for 12 months), Omeprazole (taken for 12 months), Sulindac (taken for 2 months).\nSelf-reported data: Has medical history of hypertension; arthritis; stroke; thyroid problem. Family history of arthritis. Engages in moderate home or yard tasks. Reproductive history: has been pregnant; had hysterectomy at age 28; had one ovary removed; first period at age 11; previously took birth control pills.", | |
| "answer": "C", | |
| "ground_truth_note": "SEQN 1918: Deceased at 7 years 3 months, cause: unclassified causes" | |
| }, | |
| { | |
| "pool": "geodnam_age_pairwise", | |
| "display_name": "GEO DNAm Age / Pairwise", | |
| "domain": "epigenomics", | |
| "lb_code": "LB-0006", | |
| "prompt": "Based on the following DNA methylation profiles from blood samples, which individual is older?\n\nOptions: A: A male, from Denmark. ; B: A female, from United Kingdom, diagnosed with type 1 diabetes.\n\nDNA methylation data:\nThe following CpG sites show the largest methylation differences between the two individuals: cg07314414 (chr2:128027349, +, CpG Island). In SAP130 (Sin3A associated protein 130) body (intron_1), 775bp downstream of TSS. Process: negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of stem cell population maintenance, positive regulation of stem cell population maintenance. Component: Sin3-type complex, nuclear speck, nucleus. A: 0.12, B: 0.67, B much higher. | cg18059933 (chr8:94950235, +, S_Shore 91bp). In TP53INP1 (tumor protein p53 inducible nuclear protein 1) promoter, 840bp upstream of TSS; NDUFAF6 (NADH:ubiquinone oxidoreductase complex assembly factor 6) body, 55kbp downstream of TSS. Process: negative regulation of cell population proliferation, positive regulation of DNA-templated transcription, cellular oxidant detoxification, autophagosome assembly. Function: antioxidant activity, protein binding. Component: cytoplasmic vesicle, autophagosome, nucleoplasm, PML body. Process: mitochondrial respiratory chain complex I assembly. Function: protein binding. Component: cytoplasm, mitochondrial inner membrane, mitochondrion, nucleus. A: 0.62, B: 0.11, A much higher. | cg15572745 (chr14:78403889, -, OpenSea). In NRXN3 (neurexin 3) body (intron_4), 234kbp downstream of TSS. Process: trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission, gephyrin clustering involved in postsynaptic density assembly, nervous system development, neuron cell-cell adhesion. Function: transmembrane signaling receptor activity, neuroligin family protein binding, cell adhesion molecule binding, metal ion binding. Component: presynaptic active zone membrane, trans-synaptic protein complex, plasma membrane, synapse. A: 0.82, B: 0.35, A much higher. | cg15470298 (chr21:45405307, -, N_Shore 54bp). In COL18A1 (collagen type XVIII alpha 1 chain) body (intron_1), 184bp downstream of TSS; BNAT1 promoter, 364bp upstream of TSS. Process: negative regulation of cell population proliferation, anatomical structure morphogenesis, extracellular matrix organization, response to hydrostatic pressure. Function: extracellular matrix structural constituent conferring tensile strength, identical protein binding, metal ion binding, protein binding. Component: endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular region. A: 0.07, B: 0.53, B much higher. | cg13877915 (chr19:58440305, +, CpG Island). In ZNF132 (zinc finger protein 132) promoter, 152bp upstream of TSS; ZNF132-DT promoter, 143bp upstream of TSS. Process: negative regulation of transcription by RNA polymerase II, positive regulation of biosynthetic process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding. Component: nucleus. A: 0.54, B: 0.09, A much higher. | cg06730286 (chr16:1607371, +, N_Shelf 2683bp). In IFT140 (intraflagellar transport 140) body (intron_2), 5kbp downstream of TSS; ENSG00000260989 body (intron_2), 27kbp downstream of TSS. Process: protein localization to non-motile cilium, intraciliary anterograde transport, regulation of cilium assembly, cell projection organization. Function: protein binding, protein carrier chaperone. Component: intraciliary transport particle A, photoreceptor connecting cilium, photoreceptor outer segment, ciliary basal body. A: 0.93, B: 0.49, A much higher. | cg24820250 (chr12:9932337, +, OpenSea). In CLEC2A (C-type lectin domain family 2 member A) body (exon_1), 33bp downstream of TSS. Process: NK T cell activation, T cell receptor signaling pathway, natural killer cell mediated cytotoxicity. Function: natural killer cell lectin-like receptor binding, protein homodimerization activity, identical protein binding, receptor ligand activity. Component: external side of plasma membrane, plasma membrane. A: 0.91, B: 0.47, A much higher. | cg21835643 (chr20:45306721, +, CpG Island). In RBPJL (recombination signal binding protein for immunoglobulin kappa J region like) promoter, 119bp upstream of TSS; MATN4 (matrilin 4) body (intron_1), 6kbp downstream of TSS. Process: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, signal transduction. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, chromatin binding. Component: chromatin, nucleus, transcription regulator complex. Process: extracellular matrix organization. Function: calcium ion binding, protein binding. Component: extracellular matrix, extracellular region. A: 0.19, B: 0.60, B much higher. | cg18771300 (chr14:63205019, +, OpenSea). In RHOJ (ras homolog family member J) body (exon_1), 905bp downstream of TSS. Process: positive regulation of cell migration involved in sprouting angiogenesis, small GTPase-mediated signal transduction, actin cytoskeleton organization, establishment of cell polarity. Function: protein kinase binding, nucleotide binding, GTPase activity, GTP binding. Component: extracellular exosome, plasma membrane. A: 0.39, B: 0.79, B much higher. | cg19471399 (chr12:405086, -, S_Shelf 3461bp). In CCDC77 (coiled-coil domain containing 77) body (intron_1), 16kbp downstream of TSS. Component: centrosome, membrane. A: 0.88, B: 0.48, A much higher. | cg14747225 (chr16:53024, -, N_Shore 401bp). In POLR3K (RNA polymerase III subunit K) body (intron_1), 634bp downstream of TSS; SNRNP25 (small nuclear ribonucleoprotein U11/U12 subunit 25) promoter, 804bp upstream of TSS. Process: transcription initiation at RNA polymerase III promoter, DNA-templated transcription, defense response to virus, innate immune response. Function: DNA-directed RNA polymerase activity, metal ion binding, nucleic acid binding, zinc ion binding. Component: DNA-directed RNA polymerase complex, nucleoplasm, cytosol, nucleus. Process: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosome conformational change to release U4 (or U4atac) and U1 (or U11). Function: protein binding. Component: U12-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex. A: 0.06, B: 0.45, B much higher. | cg21649520 (chr8:81447564, -, OpenSea). In PMP2 (peripheral myelin protein 2) promoter, 46bp upstream of TSS; ENSG00000253374 body (intron_2), 8kbp downstream of TSS. Process: fatty acid transport, membrane organization. Function: cholesterol binding, fatty acid binding, lipid binding, protein binding. Component: extracellular exosome, myelin sheath, cytoplasm, cytosol. A: 0.87, B: 0.48, A much higher. | cg05863612 (chr10:99972076, +, OpenSea). In DNMBP (dynamin binding protein) body (exon_2), 38kbp downstream of TSS. Process: cilium assembly, intracellular signal transduction, regulation of cell shape, regulation of small GTPase mediated signal transduction. Function: guanyl-nucleotide exchange factor activity, protein binding. Component: anchoring junction, cell-cell junction, Golgi apparatus, cytoskeleton. A: 0.92, B: 0.54, A much higher. | cg15364618 (chr14:24311345, +, CpG Island). In CIDEB (cell death inducing DFFA like effector b) body, 95bp downstream of TSS; LTB4R (leukotriene B4 receptor) promoter, 105bp upstream of TSS. Process: intrinsic apoptotic signaling pathway in response to DNA damage, very-low-density lipoprotein particle assembly, regulation of triglyceride metabolic process, COPII-coated vesicle cargo loading. Function: molecular adaptor activity, identical protein binding, phosphatidic acid binding, lipid transfer activity. Component: perinuclear region of cytoplasm, endoplasmic reticulum membrane, COPI-coated vesicle, cytoplasmic vesicle. Process: phospholipase C-activating G protein-coupled receptor signaling pathway, inflammatory response, signal transduction, muscle contraction. Function: G protein-coupled peptide receptor activity, leukotriene B4 receptor activity, nucleotide binding, G protein-coupled receptor activity. Component: membrane, plasma membrane. A: 0.19, B: 0.57, B much higher. | cg18370979 (chr5:94076132, -, OpenSea). In ARB2A (ARB2 cotranscriptional regulator A) body (intron_1), 36kbp downstream of TSS. Process: regulation of alternative mRNA splicing, via spliceosome, regulatory ncRNA-mediated heterochromatin formation, neural crest cell development, mRNA processing. Function: protein binding, siRNA binding. Component: endoplasmic reticulum, nucleoplasm, cytoplasm, cytosol. A: 0.91, B: 0.53, A much higher. | cg03336167 (chr11:2909765, -, CpG Island). In SLC67A1 (solute carrier family 67 member 1) body (intron_5), 10kbp downstream of TSS. Process: xenobiotic detoxification by transmembrane export across the plasma membrane, organic cation transport, transmembrane transport, xenobiotic transport. Function: protein binding, transmembrane transporter activity, ubiquitin protein ligase binding, xenobiotic transmembrane transporter activity. Component: apical plasma membrane, nuclear envelope, cytoplasm, plasma membrane. A: 0.41, B: 0.78, B much higher. | cg14717946 (chr1:205121713, +, OpenSea). In RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit) body (intron_1), 302bp downstream of TSS; ENSG00000307332 promoter, 582bp upstream of TSS. Process: DNA damage response, chromatin organization, response to estrogen, transcription initiation-coupled chromatin remodeling. Function: histone binding, protein binding, transcription cis-regulatory region binding. Component: histone methyltransferase complex, Set1C/COMPASS complex, MLL3/4 complex, MLL1 complex. A: 0.10, B: 0.46, B much higher. | cg22975568 (chr5:150413873, -, OpenSea). In CD74 (CD74 molecule) promoter, 904bp upstream of TSS. Process: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of macrophage migration inhibitory factor signaling pathway, positive regulation of dendritic cell antigen processing and presentation, positive regulation of chemokine (C-X-C motif) ligand 2 production. Function: MHC class II protein binding, via antigen binding groove, macrophage migration inhibitory factor binding, nitric-oxide synthase binding, cytokine receptor activity. Component: macrophage migration inhibitory factor receptor complex, lumenal side of endoplasmic reticulum membrane, clathrin-coated endocytic vesicle membrane, ER to Golgi transport vesicle membrane. A: 0.92, B: 0.56, A much higher. | cg16248277 (chr10:101776306, -, CpG Island). In FGF8 (fibroblast growth factor 8) body, 4kbp downstream of TSS. Process: epithelial to mesenchymal transition involved in endocardial cushion formation, negative regulation of cardiac muscle tissue development, positive regulation of cell population proliferation, fibroblast growth factor receptor signaling pathway. Function: chemoattractant activity, growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding. Component: cytoplasm, external side of plasma membrane, extracellular region, extracellular space. A: 0.09, B: 0.44, B much higher. | cg16474696 (chr19:13764200, -, N_Shore 31bp). In MRI1 (methylthioribose-1-phosphate isomerase 1) promoter, 322bp upstream of TSS. Process: L-methionine salvage from methylthioadenosine, amino acid biosynthetic process. Function: S-methyl-5-thioribose-1-phosphate isomerase activity, identical protein binding, isomerase activity, protein binding. Component: cell projection, nucleoplasm, cytoplasm, cytosol. A: 0.31, B: 0.66, B much higher. | cg01623187 (chr20:43727499, -, OpenSea). In GTSF1L (gametocyte specific factor 1 like) promoter, 497bp upstream of TSS. Function: metal ion binding, protein binding, protein-containing complex binding, zinc ion binding. A: 0.93, B: 0.59, A much higher. | cg03584646 (chr2:101060051, +, OpenSea). In TBC1D8 (TBC1 domain family member 8) body (intron_2), 193kbp downstream of TSS. Process: blood circulation, positive regulation of cell population proliferation, system process. Function: GTPase activator activity, protein binding. Component: membrane. A: 0.94, B: 0.61, A much higher. | cg07496902 (chr3:57280420, +, OpenSea). In ASB14 (ankyrin repeat and SOCS box containing 14) body (exon_7), 12kbp downstream of TSS. Process: intracellular signal transduction, protein ubiquitination. Component: cytosol. A: 0.92, B: 0.59, A much higher. | cg18392482 (chr12:95944233, +, S_Shore 600bp). In AMDHD1 (amidohydrolase domain containing 1) body (intron_1), 932bp downstream of TSS; ENSG00000302609 promoter, 1kbp upstream of TSS. Process: L-histidine catabolic process, L-histidine metabolic process. Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, imidazolonepropionase activity, hydrolase activity, molecular_function. Component: cytoplasm, cytosol. A: 0.73, B: 0.40, A much higher. | cg07236943 (chr7:94655174, +, N_Shore 373bp). In PEG10 (paternally expressed 10) promoter, 1kbp upstream of TSS; SGCE (sarcoglycan epsilon) body (intron_1), 1kbp downstream of TSS. Process: negative regulation of transforming growth factor beta receptor signaling pathway, vesicle-mediated intercellular transport, viral translational frameshifting, protein homooligomerization. Function: nucleic acid binding, metal ion binding, protein binding, mRNA binding. Component: cytoplasm, extracellular vesicle, nucleus. Process: cell-matrix adhesion, muscle organ development, synaptic signaling. Component: dystrophin-associated glycoprotein complex, endoplasmic reticulum membrane, sarcoglycan complex, dendrite membrane. A: 0.12, B: 0.44, B much higher. | cg23126915 (chr7:152677232, -, S_Shore 896bp). In XRCC2 (X-ray repair cross complementing 2) promoter, 1kbp upstream of TSS. Process: double-strand break repair via homologous recombination, supramolecular fiber organization, DNA damage response, DNA strand invasion. Function: ATP-dependent DNA damage sensor activity, four-way junction DNA binding, protein binding, ATP binding. Component: Rad51B-Rad51C-Rad51D-XRCC2 complex, replication fork, nucleoplasm, centrosome. A: 0.94, B: 0.62, A much higher. | cg25431974 (chr2:232488226, +, CpG Island). In ECEL1 (endothelin converting enzyme like 1) body, 819bp downstream of TSS; ENSG00000304480 body (exon_1), 294bp downstream of TSS. Process: neuropeptide signaling pathway, protein processing, proteolysis, respiratory system process. Function: metalloendopeptidase activity, metallopeptidase activity, hydrolase activity, peptidase activity. Component: membrane, plasma membrane. A: 0.40, B: 0.72, B much higher. | cg26117431 (chr1:100177988, -, OpenSea). In LRRC39 (leucine rich repeat containing 39) body (intron_1), 279bp downstream of TSS; ENSG00000285530 body (intron_2), 19kbp downstream of TSS. Process: intracellular signal transduction. Function: protein binding. Component: M band. A: 0.96, B: 0.64, A much higher. | cg02171545 (chr15:24848219, -, CpG Island). In SNRPN (small nuclear ribonucleoprotein polypeptide N) body, 25kbp downstream of TSS; ENSG00000280118 promoter, 113bp upstream of TSS. Process: RNA splicing, mRNA splicing, via spliceosome. Function: RNA binding, protein binding, snRNP binding. Component: small nuclear ribonucleoprotein complex, U4/U6 x U5 tri-snRNP complex, catalytic step 2 spliceosome, U2-type prespliceosome. A: 0.27, B: 0.58, B much higher. | cg03723845 (chr5:180899186, +, OpenSea). In BTNL8 (butyrophilin like 8) body (exon_1), 109bp downstream of TSS. Process: T cell receptor signaling pathway, regulation of cytokine production, extrathymic T cell selection, adaptive immune response. Function: protein binding, signaling receptor binding. Component: external side of plasma membrane, membrane, plasma membrane. A: 0.93, B: 0.62, A much higher. | cg05270634 (chr17:43025428, -, CpG Island). In RND2 (Rho family GTPase 2) body (exon_1), 206bp downstream of TSS; VAT1 (vesicle amine transport 1) promoter, 305bp upstream of TSS. Process: actin filament organization, regulation of actin cytoskeleton organization, signal transduction, small GTPase-mediated signal transduction. Function: protein kinase binding, nucleotide binding, GTPase activity, GTP binding. Component: acrosomal membrane, cytoplasmic vesicle, cytosol, plasma membrane. Process: intermembrane phospholipid transfer, lipid transport, negative regulation of mitochondrial fusion. Function: NADPH dehydrogenase (quinone) activity, quinone reductase (NADPH) activity, phospholipid transfer activity, oxidoreductase activity. Component: mitochondrial outer membrane, azurophil granule lumen, extracellular exosome, extracellular region. A: 0.07, B: 0.38, B much higher. | cg05767404 (chr1:247549289, +, OpenSea). In GCSAML (germinal center associated signaling and motility like) body (intron_1), 42kbp downstream of TSS. Process: regulation of B cell receptor signaling pathway, regulation of lymphocyte migration. Function: protein binding. A: 0.46, B: 0.15, A much higher. | cg22828602 (chr7:122698525, -, OpenSea). In RNF133 (ring finger protein 133) body (exon_1), 592bp downstream of TSS; CADPS2 (calcium dependent secretion activator 2) body (intron_2), 188kbp downstream of TSS. Process: protein autoubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process. Function: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding. Component: endoplasmic reticulum membrane, Golgi apparatus, late endosome, cytoplasm. Process: positive regulation of exocytosis, dense core granule exocytosis, synaptic vesicle exocytosis, protein transport. Function: lipid binding, metal ion binding. Component: parallel fiber to Purkinje cell synapse, cytoplasmic vesicle membrane, glutamatergic synapse, postsynaptic membrane. A: 0.77, B: 0.46, A much higher. | cg24949049 (chr13:60439107, +, OpenSea). In TDRD3 (tudor domain containing 3) body (intron_1), 43kbp downstream of TSS. Process: DNA topological change, chromatin organization, positive regulation of DNA-templated transcription, siRNA-mediated heterochromatin formation. Function: transcription coactivator activity, histone H3 reader activity, chromatin binding, protein binding. Component: DNA topoisomerase III-beta-TDRD3 complex, exon-exon junction complex, nucleoplasm, cytoplasm. A: 0.94, B: 0.63, A much higher. | cg00744433 (chr21:17511749, -, N_Shore 740bp). In CXADR (CXADR cell adhesion molecule) promoter, 1kbp upstream of TSS; ENSG00000304967 body (intron_1), 2kbp downstream of TSS. Process: AV node cell-bundle of His cell adhesion involved in cell communication, epithelial structure maintenance, actin cytoskeleton organization, cardiac muscle cell development. Function: cell adhesive protein binding involved in AV node cell-bundle of His cell communication, cell adhesion molecule binding, signaling receptor binding, virus receptor activity. Component: apicolateral plasma membrane, protein-containing complex, bicellular tight junction, neuromuscular junction. A: 0.89, B: 0.59, A much higher. | cg01739167 (chr17:4903049, +, S_Shore 942bp). In CHRNE (cholinergic receptor nicotinic epsilon subunit) body (exon_1), 31kbp downstream of TSS. Process: regulation of postsynaptic membrane potential, monoatomic cation transmembrane transport, acetylcholine receptor signaling pathway, synaptic transmission, cholinergic. Function: transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential, monoatomic cation transmembrane transporter activity, transmembrane signaling receptor activity, acetylcholine-gated monoatomic cation-selective channel activity. Component: acetylcholine-gated channel complex, neuromuscular junction, postsynaptic membrane, neuron projection. A: 0.45, B: 0.15, A much higher. | cg06653796 (chr20:63736453, -, N_Shore 1150bp). In LIME1 (Lck interacting transmembrane adaptor 1) body, 170bp downstream of TSS; ENSG00000273154 body (intron_2), 28kbp downstream of TSS. Process: B cell receptor signaling pathway, T cell receptor signaling pathway, adaptive immune response, immune system process. Function: protein binding, protein kinase binding. Component: B cell receptor complex, extracellular space, plasma membrane. A: 0.27, B: 0.57, B much higher. | cg06785822 (chr2:10141203, -, OpenSea). In RRM2 (ribonucleotide reductase regulatory subunit M2) body, 21kbp downstream of TSS. Process: positive regulation of G1/S transition of mitotic cell cycle, ribonucleoside diphosphate metabolic process, 2'-deoxyribonucleotide biosynthetic process, protein heterotetramerization. Function: ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor, protein homodimerization activity, identical protein binding, oxidoreductase activity. Component: ribonucleoside-diphosphate reductase complex, nucleoplasm, cytoplasm, cytosol. A: 0.90, B: 0.60, A much higher. | cg16636110 (chr19:57191111, +, N_Shore 218bp). In ZNF264 (zinc finger protein 264) promoter, 389bp upstream of TSS. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Component: nucleus. A: 0.53, B: 0.83, B much higher. | cg19235307 (chr3:129441311, +, S_Shore 677bp). In MBD4 (methyl-CpG binding domain 4, DNA glycosylase) promoter, 768bp upstream of TSS; IFT122 (intraflagellar transport 122) body (intron_1), 12kbp downstream of TSS. Process: DNA damage response, DNA repair, depyrimidination, response to estradiol. Function: pyrimidine-specific mismatch base pair DNA N-glycosylase activity, satellite DNA binding, catalytic activity, hydrolase activity. Component: nuclear speck, nucleoplasm, nucleus. Process: negative regulation of smoothened signaling pathway, establishment of protein localization to organelle, embryonic heart tube left/right pattern formation, spinal cord dorsal/ventral patterning. Function: protein binding, protein carrier chaperone. Component: intraciliary transport particle A, photoreceptor connecting cilium, ciliary transition zone, ciliary basal body. A: 0.42, B: 0.12, A much higher. | cg19515518 (chr11:694717, -, CpG Island). In EPS8L2 (EPS8 signaling adaptor L2) body, 279bp downstream of TSS; TMEM80 (transmembrane protein 80) promoter, 874bp upstream of TSS. Process: Rho protein signal transduction, positive regulation of ruffle assembly, regulation of Rho protein signal transduction, sensory perception of sound. Function: actin binding, cadherin binding, guanyl-nucleotide exchange factor activity, protein binding. Component: protein-containing complex, extracellular exosome, stereocilium bundle, stereocilium tip. Process: non-motile cilium assembly. Function: protein binding. Component: ciliary transition zone, cilium, membrane. A: 0.07, B: 0.37, B much higher. | cg19763281 (chr1:31189188, +, OpenSea). In NKAIN1 (sodium/potassium transporting ATPase interacting 1) body (intron_1), 51kbp downstream of TSS. Process: regulation of sodium ion transport. Function: ATPase binding. Component: plasma membrane. A: 0.93, B: 0.63, A much higher. | cg23762517 (chr1:41918639, +, S_Shore 307bp). In HIVEP3 (HIVEP zinc finger 3) body (exon_1), 117kbp downstream of TSS. Process: positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Component: cytoplasm, nucleus. A: 0.56, B: 0.26, A much higher. | cg24169822 (chr7:27131375, +, S_Shore 356bp). In HOXA4 (homeobox A4) promoter, 595bp upstream of TSS; HOXA3 (homeobox A3) body (intron_2), 21kbp downstream of TSS. Process: positive regulation of transcription by RNA polymerase II, anterior/posterior pattern specification, embryonic skeletal system morphogenesis, anatomical structure morphogenesis. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, DNA-binding transcription factor activity. Component: chromatin, nuclear body, nucleoplasm, nucleus. Process: regulation of transcription by RNA polymerase II, anterior/posterior pattern specification, embryonic skeletal system morphogenesis, angiogenesis. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, HMG box domain binding, protein binding. Component: chromatin, nucleoplasm, nucleus. A: 0.33, B: 0.63, B much higher. | cg00521434 (chr1:109539343, +, OpenSea). In GPR61 (G protein-coupled receptor 61) promoter, 529bp upstream of TSS. Process: G protein-coupled receptor signaling pathway, ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway, signal transduction. Function: G protein-coupled receptor activity, arrestin family protein binding, protein binding. Component: endosome membrane, receptor complex, plasma membrane, endosome. A: 0.94, B: 0.65, A much higher. | cg06638451 (chr3:58577542, +, OpenSea). In FAM107A (family with sequence similarity 107 member A) body, 50kbp downstream of TSS. Process: negative regulation of G1/S transition of mitotic cell cycle, negative regulation of long-term synaptic potentiation, regulation of microtubule cytoskeleton organization, negative regulation of focal adhesion assembly. Function: actin binding, protein binding. Component: actin cytoskeleton, neuron projection, ruffle membrane, focal adhesion. A: 0.54, B: 0.83, B much higher. | cg07073964 (chr19:698371, -, OpenSea). In ENSG00000304043 body (intron_1), 5kbp downstream of TSS. A: 0.58, B: 0.29, A much higher. | cg09563216 (chr1:150282831, -, S_Shore 605bp). In CIART (circadian associated repressor of transcription) body (exon_1), 288bp downstream of TSS; ENSG00000289041 promoter, 442bp upstream of TSS. Process: circadian regulation of gene expression, locomotor rhythm, negative regulation of DNA-templated transcription, rhythmic process. Function: E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, transcription cis-regulatory region binding. Component: PML body, nucleus. A: 0.58, B: 0.29, A much higher. | cg13494498 (chr16:89923806, -, CpG Island). In TUBB3 (tubulin beta 3 class III) body (intron_1), 2kbp downstream of TSS; ENSG00000198211 body (intron_2), 5kbp downstream of TSS. Process: microtubule cytoskeleton organization, netrin-activated signaling pathway, dorsal root ganglion development, microtubule-based process. Function: structural constituent of cytoskeleton, netrin receptor binding, nucleotide binding, metal ion binding. Component: microtubule cytoskeleton, extracellular exosome, sperm principal piece, intercellular bridge. A: 0.38, B: 0.09, A much higher. | cg15456206 (chr19:55640773, +, CpG Island). In CCDC106 (coiled-coil domain containing 106) promoter, 289bp upstream of TSS; ZNF581 (zinc finger protein 581) body, 6kbp downstream of TSS. Function: protein binding. Component: nucleoplasm, nucleus. Process: regulation of transcription by RNA polymerase II. Function: RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, metal ion binding, protein binding. Component: nucleus. A: 0.34, B: 0.05, A much higher. | cg15775914 (chr1:241635782, +, OpenSea). In CHML (CHM like Rab escort protein) body (exon_2), 5kbp downstream of TSS; OPN3 (opsin 3) body (intron_1), 42kbp downstream of TSS. Process: small GTPase-mediated signal transduction, intracellular protein transport, protein targeting to membrane, protein geranylgeranylation. Function: GDP-dissociation inhibitor activity, GTPase activator activity, small GTPase binding. Component: Rab-protein geranylgeranyltransferase complex, cytosol, nucleoplasm, nucleus. Process: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, positive regulation of D-glucose import across plasma membrane, negative regulation of melanin biosynthetic process, cellular response to light stimulus. Function: G protein-coupled photoreceptor activity, all-trans retinal binding, protein binding, G protein-coupled receptor activity. Component: photoreceptor outer segment, plasma membrane, cytoplasm, cytosol. A: 0.71, B: 0.42, A much higher. | cg17688525 (chr18:6414979, +, CpG Island). In L3MBTL4 (L3MBTL histone methyl-lysine binding protein 4) body, 498bp downstream of TSS; LINC01387 body (intron_1), 1kbp downstream of TSS. Process: negative regulation of DNA-templated transcription, regulation of macromolecule metabolic process, chromatin organization, regulation of DNA-templated transcription. Function: chromatin binding, metal ion binding, histone binding, protein binding. Component: nucleus. A: 0.37, B: 0.08, A much higher. | cg23818978 (chr11:118212524, +, OpenSea). In JAML (junction adhesion molecule like) body (exon_3), 14kbp downstream of TSS. Process: positive regulation of epithelial cell proliferation involved in wound healing, heterophilic cell-cell adhesion, gamma-delta T cell activation, neutrophil extravasation. Function: cell adhesion molecule binding, integrin binding, protein binding, protein homodimerization activity. Component: anchoring junction, bicellular tight junction, membrane, plasma membrane. A: 0.79, B: 0.50, A much higher. | cg01035238 (chr2:151356717, +, OpenSea). In TNFAIP6 (TNF alpha induced protein 6) promoter, 875bp upstream of TSS; ENSG00000295625 body (intron_2), 23kbp downstream of TSS. Process: negative regulation of osteoblast differentiation, positive regulation of receptor clustering, fibronectin fibril organization, hyaluronan metabolic process. Function: carboxylesterase activity, hyaluronic acid binding, calcium ion binding, fibronectin binding. Component: extracellular region, extracellular space, ficolin-1-rich granule lumen, tertiary granule lumen. A: 0.91, B: 0.63, A much higher. | cg03007010 (chr19:35775938, +, S_Shore 71bp). In ARHGAP33 (Rho GTPase activating protein 33) body (intron_1), 1kbp downstream of TSS. Process: regulation of dendritic spine morphogenesis, small GTPase-mediated signal transduction, regulation of postsynapse assembly, protein transport. Function: GTPase activator activity, phosphatidylinositol binding, protein binding, protein kinase binding. Component: protein-containing complex, glutamatergic synapse, postsynaptic density, plasma membrane. A: 0.07, B: 0.35, B much higher. | cg04452713 (chr6:56842889, +, N_Shore 373bp). In DST (dystonin) body (intron_4), 112kbp downstream of TSS; DST-AS1 promoter, 1kbp upstream of TSS. Process: intermediate filament cytoskeleton organization, integrin-mediated signaling pathway, maintenance of cell polarity, retrograde axonal transport. Function: protein homodimerization activity, microtubule plus-end binding, structural molecule activity, calcium ion binding. Component: intermediate filament cytoskeleton, endoplasmic reticulum membrane, polymeric cytoskeletal fiber, microtubule cytoskeleton. A: 0.12, B: 0.40, B much higher. | cg07077459 (chr6:144007915, -, CpG Island). In PLAGL1 (PLAG1 like zinc finger 1) body (intron_1), 57kbp downstream of TSS; HYMAI body (exon_1), 347bp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, regulation of immune system process, regulation of cytokine production, regulation of cell cycle. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, metal ion binding, protein binding. Component: cytoplasm, nuclear body, nucleoplasm, nucleus. A: 0.51, B: 0.79, B much higher. | cg09390932 (chr2:62193215, +, N_Shore 1842bp). In ENSG00000229839 body (intron_1), 3kbp downstream of TSS. A: 0.94, B: 0.66, A much higher. | cg12247247 (chr17:38853608, +, CpG Island). In RPL23 (ribosomal protein L23) body (intron_1), 15kbp downstream of TSS; SNORA21 promoter, 614bp upstream of TSS. Process: negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of signal transduction by p53 class mediator, negative regulation of transcription by RNA polymerase II, positive regulation of cell population proliferation. Function: large ribosomal subunit rRNA binding, ubiquitin ligase inhibitor activity, structural constituent of ribosome, transcription coactivator binding. Component: cytosolic large ribosomal subunit, protein-containing complex, ribonucleoprotein complex, extracellular exosome. A: 0.12, B: 0.40, B much higher. | cg14009688 (chr7:134779491, -, OpenSea). In CALD1 (caldesmon 1) body, 35kbp downstream of TSS; ENSG00000286458 body (intron_3), 298kbp downstream of TSS. Process: actin filament bundle assembly, muscle contraction. Function: tropomyosin binding, calmodulin binding, cadherin binding, protein binding. Component: actin cytoskeleton, plasma membrane, stress fiber, myofibril. A: 0.58, B: 0.30, A much higher. | cg20283107 (chr8:123776729, +, OpenSea). In FAM91A1 (family with sequence similarity 91 member A1) body (intron_3), 8kbp downstream of TSS. Process: intracellular protein transport, vesicle tethering to Golgi. Function: protein binding. Component: Golgi apparatus, cytoplasmic vesicle, trans-Golgi network. A: 0.61, B: 0.33, A much higher. | cg24469977 (chr7:132648632, +, OpenSea). In PLXNA4 (plexin A4) body, 56bp downstream of TSS; FLJ40288 promoter, 162bp upstream of TSS. Process: regulation of axon extension involved in axon guidance, trigeminal nerve structural organization, cell surface receptor signaling pathway, branchiomotor neuron axon guidance. Function: protein binding, semaphorin receptor activity, signaling receptor activity. Component: cerebellar climbing fiber to Purkinje cell synapse, plasma membrane, semaphorin receptor complex. A: 0.92, B: 0.64, A much higher. | cg25193494 (chr16:89949596, -, CpG Island). In DEF8 (differentially expressed in FDCP 8 homolog) body (intron_2), 1kbp downstream of TSS. Process: lysosome localization, positive regulation of bone resorption, positive regulation of ruffle assembly. Function: metal ion binding, protein binding, zinc ion binding. A: 0.69, B: 0.41, A much higher. | cg25414165 (chr10:75782730, +, OpenSea). In LRMDA (leucine rich melanocyte differentiation associated) body (intron_2), 351kbp downstream of TSS. Process: cell differentiation, melanocyte differentiation. Component: nucleoplasm. A: 0.88, B: 0.60, A much higher. | cg26180557 (chr7:39006189, -, OpenSea). In POU6F2 (POU class 6 homeobox 2) body (intron_1), 28kbp downstream of TSS; POU6F2-AS2 body (intron_1), 7kbp downstream of TSS. Process: central nervous system development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, visual perception. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, DNA-binding transcription factor activity. Component: RNA polymerase II transcription regulator complex, chromatin, nucleus. A: 0.93, B: 0.65, A much higher. | cg00687674 (chr15:69080920, +, OpenSea). In EWSAT1 body (intron_2), 14kbp downstream of TSS; ENSG00000306951 body (intron_2), 45kbp downstream of TSS. A: 0.35, B: 0.62, B much higher. | cg01081263 (chr11:9090924, -, CpG Island). In SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2) body (intron_1), 47kbp downstream of TSS; MIR5691 promoter, 545bp upstream of TSS. Process: signal transduction. Function: calcium ion binding, lipid binding, protein binding. Component: cell surface, extracellular region, extracellular space. A: 0.41, B: 0.14, A much higher. | cg05373692 (chrX:75523540, +, S_Shore 258bp). In ZDHHC15 (zDHHC palmitoyltransferase 15) promoter, 38bp upstream of TSS; ENSG00000302260 body (exon_1), 303bp downstream of TSS. Process: positive regulation of dendrite development, regulation of dendritic spine morphogenesis, peptidyl-L-cysteine S-palmitoylation, protein targeting to Golgi apparatus. Function: protein-cysteine S-myristoyltransferase activity, palmitoyltransferase activity, acyltransferase activity, transferase activity. Component: endoplasmic reticulum, postsynaptic density, Golgi apparatus, Golgi membrane. A: 0.28, B: 0.55, B much higher. | cg10281002 (chr12:114408594, -, N_Shore 177bp). In TBX5 (T-box transcription factor 5) body, 509bp downstream of TSS; TBX5-AS1 body (intron_3), 4kbp downstream of TSS. Process: positive regulation of cell communication by electrical coupling involved in cardiac conduction, regulation of atrial cardiac muscle cell membrane depolarization, negative regulation of epithelial to mesenchymal transition, positive regulation of transcription by RNA polymerase II. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, protein binding. Component: transcription regulator complex, protein-containing complex, protein-DNA complex, nucleoplasm. A: 0.21, B: 0.48, B much higher. | cg15661409 (chr14:57494258, +, OpenSea). In CCDC198 (coiled-coil domain containing 198) promoter, 386bp upstream of TSS. Process: energy homeostasis. Function: protein binding. Component: cytoplasmic vesicle, plasma membrane. A: 0.91, B: 0.64, A much higher. | cg17983064 (chr5:132060664, +, OpenSea). In IL3 (interleukin 3) body (exon_1), 9bp downstream of TSS; ENSG00000303119 body (intron_1), 2kbp downstream of TSS. Process: positive regulation of cell population proliferation, cell surface receptor signaling pathway via STAT, nervous system development, embryonic hemopoiesis. Function: cytokine activity, growth factor activity, interleukin-3 receptor binding, protein binding. Component: extracellular region, extracellular space. A: 0.56, B: 0.83, B much higher. | cg23338195 (chr8:117134179, -, OpenSea). In SLC30A8 (solute carrier family 30 member 8) body, 184kbp downstream of TSS. Process: positive regulation of insulin secretion, regulation of vesicle-mediated transport, zinc ion import across plasma membrane, intracellular zinc ion homeostasis. Function: monoatomic cation transmembrane transporter activity, protein homodimerization activity, zinc:proton antiporter activity, metal ion binding. Component: secretory granule membrane, transport vesicle membrane, cytoplasmic vesicle, plasma membrane. A: 0.73, B: 0.46, A much higher. | cg24776019 (chr3:47123431, -, OpenSea). In SETD2 (SET domain containing 2, histone lysine methyltransferase) body (exon_3), 41kbp downstream of TSS; ENSG00000296084 body (intron_1), 5kbp downstream of TSS. Process: regulation of double-strand break repair via homologous recombination, microtubule cytoskeleton organization involved in mitosis, positive regulation of interferon-alpha production, regulation of protein localization to chromatin. Function: histone H3K36 trimethyltransferase activity, protein-lysine N-methyltransferase activity, histone H3 methyltransferase activity, alpha-tubulin binding. Component: chromosome, cytoplasm, nucleoplasm, nucleus. A: 0.91, B: 0.64, A much higher. | cg25177139 (chr4:86848936, +, OpenSea). In SLC10A6 (solute carrier family 10 member 6) body (exon_1), 448bp downstream of TSS. Process: sodium-dependent organic anion transport, bile acid and bile salt transport, monoatomic ion transport, transmembrane transport. Function: bile acid:sodium symporter activity, protein binding, symporter activity. Component: membrane, plasma membrane. A: 0.95, B: 0.68, A much higher. | cg26594445 (chr11:65121133, +, N_Shore 532bp). In MRPL49 (mitochondrial ribosomal protein L49) promoter, 1kbp upstream of TSS; FAU (FAU ubiquitin like and ribosomal protein S30 fusion) body (intron_3), 1kbp downstream of TSS. Process: mitochondrial translation, translation. Function: protein binding, structural constituent of ribosome. Component: mitochondrial large ribosomal subunit, mitochondrial inner membrane, ribonucleoprotein complex, mitochondrial ribosome. Process: antimicrobial humoral immune response mediated by antimicrobial peptide, modification-dependent protein catabolic process, defense response to Gram-positive bacterium, innate immune response in mucosa. Function: RNA binding, protein binding, protein tag activity, structural constituent of ribosome. Component: cytosolic small ribosomal subunit, ribonucleoprotein complex, endoplasmic reticulum, extracellular space. A: 0.90, B: 0.63, A much higher. | cg01316071 (chr14:95410659, +, OpenSea). In SYNE3 (spectrin repeat containing nuclear envelope family member 3) body (exon_18), 106kbp downstream of TSS. Process: cytoskeleton organization, establishment of protein localization to membrane, nuclear migration, regulation of cell shape. Function: actin filament binding, cytoskeleton-nuclear membrane anchor activity, protein binding. Component: meiotic nuclear membrane microtubule tethering complex, rough endoplasmic reticulum, nuclear envelope, cytoplasm. A: 0.92, B: 0.66, A much higher. | cg04001333 (chr14:75579005, +, S_Shore 246bp). In FLVCR2 (FLVCR choline and putative heme transporter 2) body (exon_1), 411bp downstream of TSS; FLVCR2-AS1 body (intron_1), 652bp downstream of TSS. Process: transport across blood-brain barrier, transmembrane transport, ethanolamine transport, choline transport. Function: ethanolamine transmembrane transporter activity, heme binding, choline transmembrane transporter activity, heme transmembrane transporter activity. Component: endoplasmic reticulum membrane, membrane, mitochondrial membrane, plasma membrane. A: 0.38, B: 0.64, B much higher. | cg04739570 (chr3:127629768, -, CpG Island). In PODXL2 (podocalyxin like 2) body (intron_1), 625bp downstream of TSS; ENSG00000285600 promoter, 719bp upstream of TSS. Process: cell adhesion, leukocyte tethering or rolling. Function: glycosaminoglycan binding, protein binding. Component: Golgi lumen, membrane, plasma membrane. A: 0.14, B: 0.40, B much higher. | cg08489623 (chr7:55834527, -, OpenSea). In SEPTIN14 (septin 14) body (exon_6), 28kbp downstream of TSS. Process: protein localization to perinuclear region of cytoplasm, cytoskeleton-dependent cytokinesis, spermatid development, neuron migration. Function: molecular adaptor activity, nucleotide binding, GTPase activity, protein binding. Component: perinuclear region of cytoplasm, microtubule cytoskeleton, cytoplasmic vesicle, cell division site. A: 0.84, B: 0.58, A much higher. | cg09646392 (chr13:108268704, +, OpenSea). In TNFSF13B (TNF superfamily member 13b) body, 17kbp downstream of TSS. Process: tumor necrosis factor-mediated signaling pathway, positive regulation of B cell proliferation, lymphocyte homeostasis, immune system process. Function: cytokine activity, signaling receptor binding, tumor necrosis factor receptor binding. Component: perinuclear region of cytoplasm, extracellular region, extracellular space, plasma membrane. A: 0.50, B: 0.24, A much higher. | cg09971646 (chr14:100727808, -, S_Shore 408bp). In DLK1 (delta like non-canonical Notch ligand 1) body (intron_1), 2kbp downstream of TSS. Process: negative regulation of osteoblast differentiation, positive regulation of bone resorption, cell differentiation, positive regulation of osteoclast differentiation. Function: calcium ion binding, protein binding. Component: cytoplasm, extracellular space, membrane. A: 0.51, B: 0.25, A much higher. | cg13697378 (chr1:68047162, +, CpG Island). In DIRAS3 (DIRAS family GTPase 3) body (exon_2), 5kbp downstream of TSS; GNG12-AS1 body (intron_2), 215kbp downstream of TSS. Process: genomic imprinting, regulation of cyclin-dependent protein serine/threonine kinase activity, signal transduction, small GTPase-mediated signal transduction. Function: GTP binding, GTPase activity, nucleotide binding, protein binding. Component: membrane, plasma membrane. A: 0.50, B: 0.76, B much higher. | cg14789590 (chr22:32457857, +, OpenSea). In BPIFC (BPI fold containing family C) body (intron_2), 7kbp downstream of TSS. Process: immune system process, innate immune response. Function: lipid binding, lipopolysaccharide binding, phospholipid binding. Component: extracellular region, extracellular space. A: 0.91, B: 0.65, A much higher. | cg15720535 (chr9:136688133, -, CpG Island). In AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2) promoter, 676bp upstream of TSS; ENSG00000301427 promoter, 85bp upstream of TSS. Process: positive regulation of cytokine-mediated signaling pathway, CDP-diacylglycerol biosynthetic process, response to xenobiotic stimulus, phospholipid metabolic process. Function: 1-acylglycerol-3-phosphate O-acyltransferase activity, acyltransferase activity, transferase activity. Component: endoplasmic reticulum membrane, specific granule membrane, plasma membrane, endoplasmic reticulum. A: 0.35, B: 0.61, B much higher. | cg17279839 (chr7:150341509, -, CpG Island). In RARRES2 (retinoic acid receptor responder 2) body (intron_1), 635bp downstream of TSS; ENSG00000301866 body, 4kbp downstream of TSS. Process: positive regulation of systemic arterial blood pressure, positive regulation of fat cell differentiation, defense response to Gram-negative bacterium, cellular response to insulin stimulus. Function: protein binding, signaling receptor binding. Component: extracellular matrix, extracellular region, extracellular space, platelet dense granule lumen. A: 0.44, B: 0.18, A much higher. | cg21070087 (chr7:43311939, +, OpenSea). In HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1) body (exon_4), 199kbp downstream of TSS. Process: negative regulation of canonical Wnt signaling pathway, protein ubiquitination, regulation of dendrite morphogenesis, ubiquitin-dependent protein catabolic process. Function: protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity. Component: cytoplasm, cytosol. A: 0.94, B: 0.68, A much higher. | cg21375825 (chr2:135837076, +, OpenSea). In LCT (lactase) body (exon_1), 108bp downstream of TSS. Process: glycosylceramide catabolic process, carbohydrate metabolic process, cellobiose catabolic process, quercetin catabolic process. Function: hydrolase activity, hydrolyzing O-glycosyl compounds, hydrolase activity, acting on glycosyl bonds, protein homodimerization activity, cellobiose glucosidase activity. Component: apical plasma membrane, external side of apical plasma membrane, plasma membrane. A: 0.95, B: 0.69, A much higher. | cg21624359 (chr19:35357899, +, OpenSea). In FFAR3 (free fatty acid receptor 3) promoter, 449bp upstream of TSS; ENSG00000288731 body (intron_2), 79kbp downstream of TSS. Process: positive regulation of acute inflammatory response to non-antigenic stimulus, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, positive regulation of cytokine production involved in immune response, regulation of insulin receptor signaling pathway. Function: G protein-coupled receptor activity, lipid binding, protein binding. Component: membrane, plasma membrane. A: 0.71, B: 0.45, A much higher. | cg25526759 (chr17:4932876, +, OpenSea). In GP1BA (glycoprotein Ib platelet subunit alpha) body (exon_2), 599bp downstream of TSS; CHRNE body, 2kbp downstream of TSS. Process: release of sequestered calcium ion into cytosol, thrombin-activated receptor signaling pathway, positive regulation of platelet activation, blood coagulation, intrinsic pathway. Function: protein binding, signaling receptor activity, thrombin-activated receptor activity. Component: external side of plasma membrane, extracellular exosome, cell surface, plasma membrane. A: 0.93, B: 0.67, A much higher. | cg25725843 (chr2:106887713, -, CpG Island). In ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2) promoter, 429bp upstream of TSS; ENSG00000303047 body (intron_1), 861bp downstream of TSS. Process: carbohydrate metabolic process, glycoprotein biosynthetic process, oligosaccharide metabolic process, sialylation. Function: beta-galactoside alpha-2,6-sialyltransferase activity, glycosyltransferase activity, sialyltransferase activity, transferase activity. Component: Golgi apparatus, Golgi cisterna membrane, Golgi membrane. A: 0.38, B: 0.12, A much higher. | cg01656216 (chr10:30984781, +, OpenSea). In ZNF438 (zinc finger protein 438) body (intron_1), 47kbp downstream of TSS. Process: negative regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific DNA binding, metal ion binding, protein binding. Component: nucleoplasm, nucleus. A: 0.87, B: 0.62, A much higher. | cg01894895 (chr9:73151378, +, OpenSea). In ANXA1 (annexin A1) body, 3kbp downstream of TSS; ENSG00000293607 body (intron_1), 107kbp downstream of TSS. Process: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, positive regulation of cell migration involved in sprouting angiogenesis, cellular response to vascular endothelial growth factor stimulus, myoblast migration involved in skeletal muscle regeneration. Function: cadherin binding involved in cell-cell adhesion, calcium-dependent phospholipid binding, phospholipase A2 inhibitor activity, phosphatidylserine binding. Component: cytoplasmic vesicle membrane, basolateral plasma membrane, early endosome membrane, extracellular exosome. A: 0.94, B: 0.69, A much higher. | cg02838492 (chr9:114099008, +, CpG Island). In KIF12 (kinesin family member 12) body (exon_3), 284bp downstream of TSS. Process: microtubule-based movement, negative regulation of fatty acid biosynthetic process, ubiquitin-dependent protein catabolic process. Function: ubiquitin-like ligase-substrate adaptor activity, microtubule motor activity, ATP hydrolysis activity, microtubule binding. Component: extracellular exosome, kinesin complex, cytoskeleton, microtubule. A: 0.61, B: 0.86, B much higher. | cg03301801 (chr1:108721661, +, OpenSea). In FNDC7 (fibronectin type III domain containing 7) body (intron_4), 9kbp downstream of TSS. Component: extracellular region. A: 0.91, B: 0.66, A much higher. | cg03399971 (chr12:57435064, +, OpenSea). In INHBC (inhibin subunit beta C) body (exon_1), 280bp downstream of TSS. Process: cell surface receptor protein serine/threonine kinase signaling pathway. Function: cytokine activity, growth factor activity, hormone activity, transforming growth factor beta receptor binding. Component: extracellular region, extracellular space. A: 0.94, B: 0.69, A much higher. | cg10235817 (chr4:3766828, -, CpG Island). In ADRA2C (adrenoceptor alpha 2C) body (exon_1), 480bp downstream of TSS. Process: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, adenylate cyclase-inhibiting adrenergic receptor signaling pathway, epidermal growth factor receptor signaling pathway, negative regulation of norepinephrine secretion. Function: alpha-2A adrenergic receptor binding, G protein-coupled receptor activity, protein heterodimerization activity, epinephrine binding. Component: cytoplasm, endosome, membrane, plasma membrane. A: 0.40, B: 0.15, A much higher. | cg12758687 (chr11:113475605, +, CpG Island). In DRD2 (dopamine receptor D2) body, 797bp downstream of TSS. Process: negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, nervous system process involved in regulation of systemic arterial blood pressure, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, positive regulation of dopamine uptake involved in synaptic transmission. Function: dopamine neurotransmitter receptor activity, coupled via Gi/Go, ionotropic glutamate receptor binding, potassium channel regulator activity, G protein-coupled receptor activity. Component: G protein-coupled receptor complex, synaptic vesicle membrane, lateral plasma membrane, glutamatergic synapse. A: 0.41, B: 0.16, A much higher. | cg15357945 (chr11:57390888, -, OpenSea). In PRG2 (proteoglycan 2, pro eosinophil major basic protein) body, 255bp downstream of TSS; ENSG00000254979 body (intron_2), 33kbp downstream of TSS. Process: defense response to bacterium, immune response, immune system process. Function: carbohydrate binding, extracellular matrix structural constituent conferring compression resistance, heparin binding, protein binding. Component: ficolin-1-rich granule lumen, extracellular exosome, extracellular matrix, extracellular region. A: 0.70, B: 0.45, A much higher. | cg15811427 (chr19:51750969, +, OpenSea). In FPR2 (formyl peptide receptor 2) promoter, 1kbp upstream of TSS; FPR1 (formyl peptide receptor 1) body (intron_1), 53kbp downstream of TSS. Process: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, immune response-regulating cell surface receptor signaling pathway, positive regulation of cytosolic calcium ion concentration. Function: G protein-coupled receptor activity, N-formyl peptide receptor activity, scavenger receptor binding, amyloid-beta binding. Component: ficolin-1-rich granule membrane, plasma membrane, cytoplasm, specific granule membrane. Process: adenylate cyclase-modulating G protein-coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, nitric oxide mediated signal transduction, innate immune response. Function: G protein-coupled receptor activity, N-formyl peptide receptor activity, scavenger receptor binding, protein binding. Component: ficolin-1-rich granule membrane, plasma membrane, cytoplasm, azurophil granule membrane. A: 0.84, B: 0.59, A much higher. | cg17346022 (chr14:34630889, -, S_Shore 617bp). In SNX6 (sorting nexin 6) promoter, 712bp upstream of TSS. Process: negative regulation of transforming growth factor beta receptor signaling pathway, regulation of postsynaptic membrane neurotransmitter receptor levels, cellular response to epidermal growth factor stimulus, negative regulation of neuron apoptotic process. Function: type I transforming growth factor beta receptor binding, protein homodimerization activity, phosphatidylinositol binding, dynactin binding. Component: retromer, tubulation complex, postsynaptic early endosome, glutamatergic synapse, cytoplasmic vesicle. A: 0.87, B: 0.62, A much higher. | cg20043466 (chr20:21125456, -, N_Shore 252bp). In KIZ (kizuna centrosomal protein) promoter, 519bp upstream of TSS. Process: spindle organization. Function: protein binding, protein kinase binding. Component: centrosome, cytoplasm. A: 0.12, B: 0.37, B much higher. | cg21929875 (chr11:124752200, -, OpenSea). In VSIG2 (V-set and immunoglobulin domain containing 2) body (exon_1), 55bp downstream of TSS. Process: lipid metabolic process. Component: membrane, plasma membrane. A: 0.59, B: 0.84, B much higher. | cg22736354 (chr6:18122488, +, CpG Island). In NHLRC1 (NHL repeat containing E3 ubiquitin protein ligase 1) body (exon_1), 189bp downstream of TSS; ENSG00000307971 promoter, 278bp upstream of TSS. Process: proteasome-mediated ubiquitin-dependent protein catabolic process, glycogen biosynthetic process, protein polyubiquitination, protein ubiquitination. Function: ubiquitin-protein transferase activity, ubiquitin protein ligase activity, metal ion binding, protein binding. Component: perinuclear region of cytoplasm, endoplasmic reticulum, nucleoplasm, cytosol. A: 0.39, B: 0.14, A much higher. | cg23577242 (chr11:30581468, +, N_Shelf 2544bp). In MPPED2 (metallophosphoesterase domain containing 2) body (intron_1), 5kbp downstream of TSS. Function: cyclic-nucleotide phosphodiesterase activity, phosphoric diester hydrolase activity, manganese ion binding, nucleotide binding. A: 0.93, B: 0.68, A much higher. | cg24046474 (chr9:127450271, +, N_Shore 594bp). In RPL12 (ribosomal protein L12) body (intron_2), 1kbp downstream of TSS; LRSAM1 (leucine rich repeat and sterile alpha motif containing 1) promoter, 1kbp upstream of TSS. Process: negative regulation of myoblast fusion, striated muscle contraction, cytoplasmic translation, spermatogenesis. Function: RNA binding, large ribosomal subunit rRNA binding, protein binding, structural constituent of ribosome. Component: cytosolic large ribosomal subunit, ribonucleoprotein complex, extracellular exosome, postsynaptic density. Process: positive regulation of autophagosome assembly, negative regulation of endocytosis, ubiquitin-dependent endocytosis, protein autoubiquitination. Function: ubiquitin-protein transferase activity, ubiquitin protein ligase activity, metal ion binding, protein binding. Component: cytoplasm, membrane. A: 0.31, B: 0.56, B much higher. | cg03970609 (chr4:70471947, -, OpenSea). In MUC7 (mucin 7, secreted) body, 41kbp downstream of TSS. Process: antimicrobial humoral immune response mediated by antimicrobial peptide, killing of cells of another organism. Function: protein binding. Component: Golgi lumen, extracellular exosome, extracellular region, plasma membrane. A: 0.85, B: 0.61, A much higher. | cg05373457 (chr8:98427720, +, CpG Island). In KCNS2 (potassium voltage-gated channel modifier subfamily S member 2) body (intron_1), 762bp downstream of TSS; STK3 (serine/threonine kinase 3) body, 515kbp downstream of TSS. Process: regulation of potassium ion transmembrane transport, protein homooligomerization, action potential, monoatomic ion transmembrane transport. Function: voltage-gated potassium channel activity, monoatomic ion channel activity, protein binding, potassium channel regulator activity. Component: voltage-gated potassium channel complex, perinuclear region of cytoplasm, monoatomic ion channel complex, plasma membrane. Process: negative regulation of cell growth involved in contact inhibition, negative regulation of canonical Wnt signaling pathway, positive regulation of apoptotic process, protein localization to centrosome. Function: protein serine/threonine kinase activator activity, transcription regulator activator activity, identical protein binding, magnesium ion binding. Component: protein-containing complex, centrosome, cytoplasm, cytosol. A: 0.45, B: 0.21, A much higher. | cg10145725 (chr12:10600873, +, OpenSea). In ENSG00000290537 promoter, 1kbp upstream of TSS. A: 0.90, B: 0.66, A much higher. | cg10281478 (chr7:95773216, +, S_Shore 96bp). In DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) body (intron_1), 757bp downstream of TSS. Process: positive regulation of mitotic cell cycle spindle assembly checkpoint, vesicle transport along microtubule, microtubule-based movement, positive regulation of intracellular transport. Function: cytoskeletal motor activity, dynein heavy chain binding, microtubule binding, spectrin binding. Component: cytoplasmic ribonucleoprotein granule, perinuclear region of cytoplasm, cytoplasmic dynein complex, male germ cell nucleus. A: 0.17, B: 0.41, B much higher. | cg10578779 (chr1:173868857, +, S_Shore 78bp). In ZBTB37 (zinc finger and BTB domain containing 37) body (intron_1), 775bp downstream of TSS; GAS5 body, 83bp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process. Function: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, DNA-binding transcription factor activity, RNA polymerase II-specific. Component: chromatin, nucleoplasm, nucleus. A: 0.06, B: 0.30, B much higher. | cg14758526 (chr11:105008956, -, OpenSea). In CASP5 (caspase 5) body (exon_2), 14kbp downstream of TSS; ENSG00000303891 body (intron_5), 136kbp downstream of TSS. Process: positive regulation of neuron apoptotic process, non-canonical inflammasome complex assembly, cellular response to mechanical stimulus, substantia nigra development. Function: cysteine-type endopeptidase activity, hydrolase activity, peptidase activity, protein binding. Component: NLRP1 inflammasome complex, cytoplasm, cytosol. A: 0.89, B: 0.65, A much higher. | cg14880655 (chr20:34545701, -, OpenSea). In MAP1LC3A (microtubule associated protein 1 light chain 3 alpha) promoter, 1kbp upstream of TSS. Process: cellular response to oxygen-glucose deprivation, SMAD protein signal transduction, response to nutrient levels, autophagy of mitochondrion. Function: phosphatidylethanolamine binding, ubiquitin protein ligase binding, phospholipid binding, microtubule binding. Component: autophagosome membrane, glutamatergic synapse, cytoplasmic vesicle, endomembrane system. A: 0.93, B: 0.69, A much higher. | cg15925792 (chr21:41426204, -, N_Shore 16bp). In MX1 (MX dynamin like GTPase 1) body, 6kbp downstream of TSS. Process: synaptic vesicle budding from presynaptic endocytic zone membrane, negative regulation of viral genome replication, interleukin-27-mediated signaling pathway, antiviral innate immune response. Function: identical protein binding, microtubule binding, nucleotide binding, GTPase activity. Component: perinuclear region of cytoplasm, endoplasmic reticulum membrane, nuclear envelope, nuclear membrane. A: 0.02, B: 0.26, B much higher. | cg19560758 (chr1:8026661, +, CpG Island). In ERRFI1 (ERBB receptor feedback inhibitor 1) promoter, 349bp upstream of TSS; ERRFI1-DT body, 248bp downstream of TSS. Process: negative regulation of epidermal growth factor-activated receptor activity, negative regulation of cardiac muscle hypertrophy in response to stress, cellular response to platelet-derived growth factor stimulus, negative regulation of tumor necrosis factor production. Function: GTPase activator activity, protein kinase binding, small GTPase binding, SH3 domain binding. Component: cytoplasm, cytosol, nucleus, plasma membrane. A: 0.32, B: 0.08, A much higher. | cg19664945 (chr2:53860206, -, S_Shore 77bp). In ASB3 (ankyrin repeat and SOCS box containing 3) promoter, 46bp upstream of TSS; GPR75 (G protein-coupled receptor 75) promoter, 239bp upstream of TSS. Process: intracellular signal transduction, protein ubiquitination. Component: cytoplasm, cytosol. Process: G protein-coupled receptor signaling pathway, chemokine-mediated signaling pathway, signal transduction. Function: C-C chemokine receptor activity, G protein-coupled receptor activity. Component: membrane, plasma membrane. A: 0.60, B: 0.84, B much higher. | cg20051177 (chr22:42216314, -, OpenSea). In TCF20 (transcription factor 20) body (intron_1), 127kbp downstream of TSS. Process: positive regulation of transcription by RNA polymerase II. Function: transcription coactivator activity, metal ion binding, protein binding, DNA binding. Component: nuclear body, nucleoplasm, nucleus. A: 0.91, B: 0.67, A much higher. | cg21992250 (chr11:60951237, -, CpG Island). In SLC15A3 (solute carrier family 15 member 3) body (exon_1), 1kbp downstream of TSS. Process: positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, dipeptide import across plasma membrane, oligopeptide transmembrane transport, peptidoglycan transport. Function: peptidoglycan transmembrane transporter activity, peptide:proton symporter activity, protein binding, dipeptide transmembrane transporter activity. Component: endosome membrane, lysosomal membrane, membrane. A: 0.36, B: 0.12, A much higher. | cg26815229 (chr1:59927261, +, S_Shore 350bp). In CYP2J2 (cytochrome P450 family 2 subfamily J member 2) promoter, 439bp upstream of TSS. Process: linoleic acid metabolic process, regulation of heart contraction, epoxygenase P450 pathway, arachidonate metabolic process. Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, hydroperoxy icosatetraenoate isomerase activity, arachidonate 11,12-epoxygenase activity, linoleic acid epoxygenase activity. Component: cytoplasm, endoplasmic reticulum membrane, extracellular exosome, intracellular membrane-bounded organelle. A: 0.16, B: 0.40, B much higher. | cg00107187 (chr14:104604661, +, CpG Island). In TMEM179 (transmembrane protein 179) body (exon_1), 986bp downstream of TSS. Component: membrane. A: 0.34, B: 0.11, A much higher. | cg01988129 (chr8:66432701, -, CpG Island). In ENSG00000285791 body (intron_1), 215bp downstream of TSS; ADHFE1 (alcohol dehydrogenase iron containing 1) body (intron_1), 234bp downstream of TSS. Process: 2-oxoglutarate metabolic process, ketone body catabolic process, lipid metabolic process. Function: alcohol dehydrogenase (NAD+) activity, hydroxyacid-oxoacid transhydrogenase activity, metal ion binding, oxidoreductase activity. Component: mitochondrial matrix, mitochondrion. A: 0.11, B: 0.34, B much higher. | cg02119982 (chr16:50697501, -, OpenSea). In NOD2 (nucleotide binding oligomerization domain containing 2) body (intron_1), 4kbp downstream of TSS. Process: positive regulation of cytokine production involved in inflammatory response, positive regulation of dendritic cell antigen processing and presentation, nucleotide-binding oligomerization domain containing 2 signaling pathway, positive regulation of non-canonical NF-kappaB signal transduction. Function: pattern recognition receptor activity, protein-containing complex binding, carbohydrate derivative binding, muramyl dipeptide binding. Component: extrinsic component of plasma membrane, protein-containing complex, phagocytic vesicle, mitochondrion. A: 0.94, B: 0.71, A much higher. | cg04319097 (chr18:5293280, -, N_Shore 1459bp). In ZBTB14 (zinc finger and BTB domain containing 14) body (exon_3), 4kbp downstream of TSS. Process: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process. Function: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, metal ion binding. Component: nucleolus, nucleoplasm, nucleus. A: 0.91, B: 0.68, A much higher. | cg08598221 (chr8:120812689, +, S_Shore 209bp). In SNTB1 (syntrophin beta 1) body, 584bp downstream of TSS; SNTB1-AS1 body (exon_1), 470bp downstream of TSS. Process: camera-type eye development, muscle contraction. Function: structural molecule activity, PDZ domain binding, calmodulin binding, protein binding. Component: dystrophin-associated glycoprotein complex, protein-containing complex, neuromuscular junction, anchoring junction. A: 0.51, B: 0.28, A much higher. | cg11049305 (chrX:64976871, +, OpenSea). In ZC4H2 (zinc finger C4H2-type containing) body, 58kbp downstream of TSS. Process: positive regulation of transcription by RNA polymerase II, regulation of transcription regulatory region DNA binding, spinal cord motor neuron differentiation, neuromuscular junction development. Function: metal ion binding, protein binding, zinc ion binding. Component: protein-containing complex, postsynaptic membrane, neuronal cell body, cytoplasm. A: 0.09, B: 0.32, B much higher. | cg12813792 (chr20:58150639, -, N_Shore 163bp). In CIMIP1 (ciliary microtubule inner protein 1) promoter, 263bp upstream of TSS; ENSG00000303272 body (intron_3), 12kbp downstream of TSS. Function: protein binding. Component: cilium. A: 0.63, B: 0.40, A much higher. | cg16367027 (chr9:113412162, +, S_Shore 1352bp). In POLE3 (DNA polymerase epsilon 3, accessory subunit) promoter, 1kbp upstream of TSS; C9orf43 (chromosome 9 open reading frame 43) body (intron_1), 2kbp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, DNA-templated DNA replication, heterochromatin formation, leading strand elongation. Function: DNA-directed DNA polymerase activity, protein heterodimerization activity, chromatin DNA binding, protein binding. Component: epsilon DNA polymerase complex, ATAC complex, nucleoplasm, chromatin. Function: protein binding. A: 0.93, B: 0.70, A much higher. | cg16483916 (chr19:5567747, +, CpG Island). In TINCR (TINCR ubiquitin domain containing) body (exon_1), 11kbp downstream of TSS. A: 0.31, B: 0.08, A much higher. | cg18902090 (chr5:140926664, +, CpG Island). In PCDHAC1 (protocadherin alpha subfamily C, 1) body (exon_1), 365bp downstream of TSS; PCDHA13 (protocadherin alpha 13) body (intron_1), 45kbp downstream of TSS. Process: cell adhesion, homophilic cell-cell adhesion, nervous system development. Function: calcium ion binding, cell adhesion molecule binding. Component: membrane, plasma membrane. Process: cell adhesion, homophilic cell-cell adhesion, nervous system development. Function: calcium ion binding, cell adhesion molecule binding. Component: membrane, plasma membrane. A: 0.31, B: 0.08, A much higher. | cg20795863 (chr2:233031409, -, OpenSea). In NEU2 (neuraminidase 2) body, 8kbp downstream of TSS. Process: glycosphingolipid catabolic process, lipid metabolic process, oligosaccharide catabolic process, glycoprotein catabolic process. Function: exo-alpha-sialidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, protein binding. Component: catalytic complex, cytoplasm, lysosome, membrane. A: 0.93, B: 0.70, A much higher. | cg20908204 (chr19:45782176, +, N_Shelf 3555bp). In DMPK (DM1 protein kinase) body (intron_1), 376bp downstream of TSS; ENSG00000268434 body (intron_2), 4kbp downstream of TSS. Process: regulation of skeletal muscle contraction by calcium ion signaling, regulation of synapse structural plasticity, intracellular calcium ion homeostasis, regulation of myotube differentiation. Function: protein serine/threonine kinase activity, myosin phosphatase regulator activity, transferase activity, nucleotide binding. Component: sarcoplasmic reticulum membrane, mitochondrial outer membrane, nuclear membrane, plasma membrane. A: 0.27, B: 0.50, B much higher. | cg21080294 (chrX:107628248, -, N_Shore 144bp). In PRPS1 (phosphoribosyl pyrophosphate synthetase 1) promoter, 180bp upstream of TSS; ENSG00000294392 body (intron_1), 241bp downstream of TSS. Process: 5-phosphoribose 1-diphosphate biosynthetic process, ribonucleoside monophosphate biosynthetic process, nucleobase-containing compound metabolic process, pyrimidine nucleotide biosynthetic process. Function: ribose phosphate diphosphokinase activity, protein homodimerization activity, identical protein binding, magnesium ion binding. Component: cytoplasm, cytosol, ribose phosphate diphosphokinase complex. A: 0.09, B: 0.32, B much higher. | cg21533958 (chr8:37795859, +, N_Shore 672bp). In ADGRA2 (adhesion G protein-coupled receptor A2) body, 12kbp downstream of TSS; ENSG00000294776 body (intron_2), 2kbp downstream of TSS. Process: positive regulation of canonical Wnt signaling pathway, regulation of establishment of blood-brain barrier, G protein-coupled receptor signaling pathway, central nervous system development. Function: G protein-coupled receptor activity, protein binding, transmembrane signaling receptor activity. Component: Wnt signalosome, plasma membrane, cell surface, filopodium. A: 0.90, B: 0.67, A much higher. | cg22378065 (chr6:144008035, +, CpG Island). In PLAGL1 body (intron_1), 57kbp downstream of TSS; HYMAI body (exon_1), 227bp downstream of TSS. A: 0.50, B: 0.73, B much higher. | cg23006204 (chr9:127938587, -, S_Shore 600bp). In DPM2 (dolichyl-phosphate mannosyltransferase subunit 2, regulatory) promoter, 721bp upstream of TSS; ENSG00000227218 body (intron_1), 23kbp downstream of TSS. Process: GPI anchor biosynthetic process, dolichol phosphate mannose biosynthetic process, dolichyl monophosphate biosynthetic process. Function: enzyme activator activity, enzyme regulator activity, protein binding. Component: dolichol-phosphate-mannose synthase complex, endoplasmic reticulum, endoplasmic reticulum membrane, glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. A: 0.61, B: 0.84, B much higher. | cg23833896 (chr8:1762880, -, N_Shore 189bp). In KBTBD11-OT1 (KBTBD11 overlapping transcript 1) promoter, 1kbp upstream of TSS; CLN8 (CLN8 transmembrane ER and ERGIC protein) body, 7kbp downstream of TSS. Process: negative regulation of proteolysis, phospholipid metabolic process, ceramide biosynthetic process, nervous system development. Function: ceramide binding, protein binding. Component: endoplasmic reticulum-Golgi intermediate compartment membrane, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum membrane. A: 0.09, B: 0.32, B much higher. | cg23896056 (chr4:83011017, +, CpG Island). In LIN54 (lin-54 DREAM MuvB core complex component) body, 2kbp downstream of TSS. Process: negative regulation of DNA-templated transcription, nucleosome organization, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription. Function: transcription regulatory region nucleic acid binding, minor groove of adenine-thymine-rich DNA binding, metal ion binding, protein binding. Component: RNA polymerase II transcription repressor complex, nucleoplasm, nucleus. A: 0.09, B: 0.32, B much higher. | cg26687173 (chr19:33132185, +, CpG Island). In WDR88 (WD repeat domain 88) body (exon_1), 95bp downstream of TSS. Function: protein binding. A: 0.65, B: 0.88, B much higher. | cg02085507 (chr19:6739181, -, N_Shore 692bp). In TRIP10 (thyroid hormone receptor interactor 10) body, 1kbp downstream of TSS. Process: actin cytoskeleton organization, cell communication, endocytosis, signal transduction. Function: identical protein binding, lipid binding, protein binding. Component: perinuclear region of cytoplasm, extracellular exosome, Golgi apparatus, plasma membrane. A: 0.44, B: 0.66, B much higher. | cg03923277 (chr12:103965954, -, CpG Island). In TDG (thymine DNA glycosylase) body (exon_1), 132bp downstream of TSS; UQCC6 (ubiquinol-cytochrome c reductase complex assembly factor 6) promoter, 232bp upstream of TSS. Process: chromosomal 5-methylcytosine DNA demethylation, oxidation pathway, epigenetic regulation of gene expression, base-excision repair, AP site formation, regulation of embryonic development. Function: pyrimidine-specific mismatch base pair DNA N-glycosylase activity, G/T mismatch-specific thymine-DNA glycosylase activity, transcription coregulator activity, double-stranded DNA binding. Component: PML body, nucleoplasm, nucleus. Process: mitochondrial respiratory chain complex III assembly, mitochondrial respiratory chain complex IV assembly. Function: protein binding. Component: mitochondrial inner membrane, mitochondrion. A: 0.47, B: 0.69, B much higher. | cg08586737 (chr7:127585895, +, CpG Island). In GCC1 (GRIP and coiled-coil domain containing 1) body, 8kbp downstream of TSS; ENSG00000295686 body (intron_1), 3kbp downstream of TSS. Function: protein binding, small GTPase binding. Component: Golgi trans cisterna, Golgi apparatus, Golgi membrane, cytoplasm. A: 0.50, B: 0.28, A much higher. | cg08972170 (chr7:30146160, -, OpenSea). In MTURN (maturin, neural progenitor differentiation regulator homolog) body (intron_1), 11kbp downstream of TSS. Process: positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of megakaryocyte differentiation, regulation of signaling. Function: protein binding. Component: cytoplasm. A: 0.69, B: 0.47, A much higher. | cg09950370 (chr8:21751861, +, S_Shore 1038bp). In GFRA2 (GDNF family receptor alpha 2) body (intron_3), 61kbp downstream of TSS. Process: cell surface receptor protein tyrosine kinase signaling pathway, glial cell-derived neurotrophic factor receptor signaling pathway, nervous system development. Function: glial cell-derived neurotrophic factor receptor activity, heparan sulfate binding, signaling receptor activity. Component: external side of plasma membrane, extrinsic component of membrane, receptor complex, side of membrane. A: 0.92, B: 0.70, A much higher. | cg12757684 (chr6:144008348, -, CpG Island). In PLAGL1 body, 56kbp downstream of TSS; HYMAI promoter, 86bp upstream of TSS. A: 0.44, B: 0.66, B much higher. | cg13218906 (chr20:64255398, -, CpG Island). In PCMTD2 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2) body, 477bp downstream of TSS. Function: protein binding, protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Component: cytoplasm. A: 0.10, B: 0.32, B much higher. | cg13870866 (chr7:35253519, -, CpG Island). In TBX20 (T-box transcription factor 20) body (exon_1), 581bp downstream of TSS; ENSG00000289335 promoter, 1kbp upstream of TSS. Process: positive regulation of epithelial to mesenchymal transition, negative regulation of transcription by RNA polymerase II, positive regulation of cardiac muscle cell proliferation, positive regulation of BMP signaling pathway. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific. Component: chromatin, cytoplasm, nucleus. A: 0.36, B: 0.14, A much higher. | cg14223995 (chr4:140568645, -, N_Shore 164bp). In UCP1 (uncoupling protein 1) body (exon_1), 356bp downstream of TSS. Process: regulation of reactive oxygen species biosynthetic process, positive regulation of cold-induced thermogenesis, cellular response to reactive oxygen species, monoatomic ion transmembrane transport. Function: oxidative phosphorylation uncoupler activity, proton transmembrane transporter activity, long-chain fatty acid binding, purine ribonucleotide binding. Component: mitochondrial envelope, mitochondrial inner membrane, mitochondrion. A: 0.29, B: 0.07, A much higher. | cg14918082 (chr17:7929919, +, S_Shore 73bp). In KCNAB3 (potassium voltage-gated channel subfamily A regulatory beta subunit 3) promoter, 63bp upstream of TSS; ENSG00000262730 body (intron_1), 703bp downstream of TSS. Process: regulation of potassium ion transmembrane transport, monoatomic ion transmembrane transport, potassium ion transmembrane transport, monoatomic ion transport. Function: voltage-gated potassium channel activity, alcohol dehydrogenase (NADP+) activity, transmembrane transporter binding, oxidoreductase activity. Component: voltage-gated potassium channel complex, monoatomic ion channel complex, plasma membrane, cytoplasm. A: 0.69, B: 0.91, B much higher. | cg18680834 (chr19:30372442, +, N_Shelf 2335bp). In ZNF536 (zinc finger protein 536) body (exon_1), 148kbp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription. Function: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, DNA-binding transcription factor activity, RNA polymerase II-specific. Component: nucleus. A: 0.76, B: 0.54, A much higher. | cg20862119 (chr12:52777233, +, OpenSea). In KRT76 (keratin 76) body (exon_1), 112bp downstream of TSS. Process: cytoskeleton organization, intermediate filament organization, keratinization. Function: protein binding, structural constituent of skin epidermis. Component: extracellular exosome, intermediate filament, keratin filament, cytosol. A: 0.92, B: 0.70, A much higher. | cg22940988 (chr15:67246108, -, OpenSea). In AAGAB (alpha and gamma adaptin binding protein) body (intron_1), 9kbp downstream of TSS. Process: protein transport. Function: protein binding. Component: cytoplasm, cytosol. A: 0.91, B: 0.69, A much higher. | cg23580000 (chr16:50288245, +, OpenSea). In ADCY7 (adenylate cyclase 7) body (exon_2), 42kbp downstream of TSS. Process: negative regulation of cytokine production involved in inflammatory response, adenylate cyclase-activating G protein-coupled receptor signaling pathway, vascular endothelial cell response to laminar fluid shear stress, positive regulation of toll-like receptor 9 signaling pathway. Function: phosphorus-oxygen lyase activity, diadenylate cyclase activity, transferase activity, nucleotide binding. Component: membrane, plasma membrane. A: 0.60, B: 0.82, B much higher. | cg25539131 (chr3:10148257, +, OpenSea). In VHL (von Hippel-Lindau tumor suppressor) body (intron_2), 6kbp downstream of TSS. Process: negative regulation of transcription elongation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of cell population proliferation. Function: ubiquitin-like ligase-substrate adaptor activity, DNA-binding transcription factor binding, transcription elongation factor activity, protein serine/threonine kinase binding. Component: endoplasmic reticulum, plasma membrane, mitochondrion, nucleoplasm. A: 0.93, B: 0.71, A much higher. | cg25857886 (chr11:126228943, +, OpenSea). In FAM118B body (intron_1), 17kbp downstream of TSS. A: 0.87, B: 0.65, A much higher. | cg25985778 (chr17:74203234, +, N_Shore 560bp). In RPL38 (ribosomal protein L38) body, 393bp downstream of TSS; MGC16275 body (intron_1), 12kbp downstream of TSS. Process: negative regulation of myoblast fusion, striated muscle contraction, cytoplasmic translation, spermatogenesis. Function: RNA binding, protein binding, structural constituent of ribosome. Component: cytosolic large ribosomal subunit, eukaryotic 80S initiation complex, ribonucleoprotein complex, endoplasmic reticulum. A: 0.29, B: 0.07, A much higher. | cg02503850 (chr10:70672796, +, CpG Island). In ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif 14) body (exon_1), 429bp downstream of TSS. Process: collagen catabolic process, collagen fibril organization, extracellular matrix organization, proteolysis. Function: metalloendopeptidase activity, metallopeptidase activity, hydrolase activity, peptidase activity. Component: extracellular matrix, extracellular region. A: 0.29, B: 0.08, A much higher. | cg02735486 (chr4:113049779, +, OpenSea). In ANK2 (ankyrin 2) body (exon_1), 232kbp downstream of TSS; ANK2-AS1 body (intron_1), 22kbp downstream of TSS. Process: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of ventricular cardiac muscle cell membrane repolarization, positive regulation of potassium ion import across plasma membrane, membrane depolarization during SA node cell action potential. Function: phosphorylation-dependent protein binding, protein-macromolecule adaptor activity, structural constituent of cytoskeleton, potassium channel activator activity. Component: basolateral plasma membrane, postsynaptic membrane, recycling endosome, intercalated disc. A: 0.82, B: 0.61, A much higher. | cg02973883 (chr14:72925606, +, N_Shore 383bp). In DCAF4 (DDB1 and CUL4 associated factor 4) promoter, 752bp upstream of TSS. Process: cell population proliferation, protein ubiquitination. Function: protein binding. Component: Cul4-RING E3 ubiquitin ligase complex, nucleoplasm. A: 0.92, B: 0.71, A much higher. | cg04592706 (chr1:94121036, +, OpenSea). In ABCA4 (ATP binding cassette subfamily A member 4) body (exon_1), 112bp downstream of TSS. Process: organic hydroxy compound transport, phototransduction, visible light, phospholipid translocation, retinoid metabolic process. Function: N-retinylidene-phosphatidylethanolamine flippase activity, ATPase-coupled intramembrane lipid transporter activity, retinol transmembrane transporter activity, all-trans retinal binding. Component: intracellular membrane-bounded organelle, rod photoreceptor disc membrane, photoreceptor outer segment, endoplasmic reticulum. A: 0.94, B: 0.73, A much higher. | cg05546044 (chr22:21868307, +, S_Shore 230bp). In MAPK1 (mitogen-activated protein kinase 1) promoter, 627bp upstream of TSS; ENSG00000294146 body (intron_1), 513bp downstream of TSS. Process: positive regulation of peptidyl-threonine phosphorylation, regulation of early endosome to late endosome transport, insulin-like growth factor receptor signaling pathway, regulation of transcription by RNA polymerase II. Function: RNA polymerase II CTD heptapeptide repeat kinase activity, protein serine/threonine kinase activity, phosphotyrosine residue binding, identical protein binding. Component: ficolin-1-rich granule lumen, endoplasmic reticulum lumen, extracellular region, Golgi apparatus. A: 0.25, B: 0.46, B much higher. | cg06291867 (chr10:90857405, +, CpG Island). In HTR7 (5-hydroxytryptamine receptor 7) body (exon_1), 634bp downstream of TSS; ENSG00000298380 body (intron_1), 948bp downstream of TSS. Process: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-activating serotonin receptor signaling pathway, chemical synaptic transmission, smooth muscle contraction. Function: G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, neurotransmitter receptor activity, protein binding. Component: trans-Golgi network membrane, plasma membrane, dendrite, synapse. A: 0.32, B: 0.11, A much higher.", | |
| "answer": "A", | |
| "ground_truth_note": "Patient-A: 74 years (GSM1506366_GSE61496, GSE61496). Patient-B: 37 years (GSM501558_GSE20067, GSE20067)." | |
| }, | |
| { | |
| "pool": "geodnam_age_multiclass", | |
| "display_name": "GEO DNAm Age / Multiclass", | |
| "domain": "epigenomics", | |
| "lb_code": "LB-0002", | |
| "prompt": "Based on the following DNA methylation profile from a blood sample, which age group does this individual most likely belong to?\n\nThe subject is A female, from Denmark.\n\nCpG methylation values:\nLowest methylated (100 sites): cg00025138 (chr14:70809200, -, CpG Island). In MAP3K9 (mitogen-activated protein kinase kinase kinase 9) body (exon_1), 345bp downstream of TSS; MAP3K9-DT body, 389bp downstream of TSS. Process: positive regulation of apoptotic process, protein autophosphorylation, protein phosphorylation, signal transduction. Function: protein serine/threonine kinase activity, molecular function activator activity, transferase activity, nucleotide binding. Component: cytoplasm. Beta: 0.01. | cg00497554 (chr2:241315743, -, CpG Island). In SEPTIN2 (septin 2) body, 820bp downstream of TSS; HDLBP (high density lipoprotein binding protein) body, 1kbp downstream of TSS. Process: cytoskeleton-dependent cytokinesis, intracellular protein localization, smoothened signaling pathway, cytoskeleton organization. Function: molecular adaptor activity, enzyme regulator activity, identical protein binding, nucleotide binding. Component: photoreceptor connecting cilium, microtubule cytoskeleton, ciliary transition zone, extracellular exosome. Process: cholesterol metabolic process, lipid metabolic process, lipid transport, steroid metabolic process. Function: nucleic acid binding, cadherin binding, protein binding, lipid binding. Component: high-density lipoprotein particle, endoplasmic reticulum, plasma membrane, nuclear body. Beta: 0.01. | cg00702638 (chr3:44761801, -, CpG Island). In KIF15 (kinesin family member 15) body (exon_1), 80bp downstream of TSS; KIAA1143 (KIAA1143) body, 232bp downstream of TSS. Process: centrosome separation, microtubule-based movement, mitotic cell cycle, mitotic spindle assembly. Function: plus-end-directed microtubule motor activity, ATP hydrolysis activity, microtubule binding, nucleotide binding. Component: plus-end kinesin complex, spindle pole, microtubule, centrosome. Function: protein binding. Component: intercellular bridge, nucleoplasm. Beta: 0.01. | cg02047577 (chr20:63956349, -, CpG Island). In UCKL1 (uridine-cytidine kinase 1 like 1) body (exon_1), 131bp downstream of TSS; UCKL1-AS1 body (exon_1), 3kbp downstream of TSS. Process: nucleobase-containing small molecule metabolic process, nucleobase-containing compound biosynthetic process, carbohydrate derivative biosynthetic process, pyrimidine-containing compound salvage. Function: cytidine kinase activity, transferase activity, nucleotide binding, protein binding. Component: cytoplasm, cytosol, nucleus. Beta: 0.01. | cg02754722 (chr6:2765958, +, CpG Island). In WRNIP1 (WRN helicase interacting protein 1) body (exon_1), 565bp downstream of TSS; MYLK4 (myosin light chain kinase family member 4) body, 4kbp downstream of TSS. Process: regulation of DNA-templated DNA replication initiation, DNA synthesis involved in DNA repair, innate immune response, immune system process. Function: single-stranded DNA helicase activity, enzyme activator activity, identical protein binding, ATP hydrolysis activity. Component: perinuclear region of cytoplasm, chromosome, telomeric region, membrane, nucleus. Process: signal transduction. Function: protein serine/threonine kinase activity, myosin light chain kinase activity, transferase activity, nucleotide binding. Component: cytoplasm. Beta: 0.01. | cg02763101 (chr19:56393576, +, CpG Island). In ZNF582 (zinc finger protein 582) promoter, 38bp upstream of TSS; ZNF582-DT promoter, 80bp upstream of TSS. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, protein binding. Component: nucleus. Beta: 0.01. | cg03342084 (chr11:43880793, -, CpG Island). In ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase) promoter, 18bp upstream of TSS; ENSG00000246250 promoter, 67bp upstream of TSS. Process: negative regulation of cytoplasmic translation, cell population proliferation, DNA alkylation repair, DNA damage response. Function: broad specificity oxidative DNA demethylase activity, mRNA N1-methyladenosine dioxygenase activity, L-ascorbic acid binding, oxidoreductase activity. Component: cytoplasm, nucleoplasm, nucleus. Beta: 0.01. | cg03970588 (chr1:182391268, +, CpG Island). In GLUL (glutamate-ammonia ligase) body (intron_1), 938bp downstream of TSS; ENSG00000306613 promoter, 839bp upstream of TSS. Process: positive regulation of erythrocyte differentiation, regulation of protein localization to nucleolus, regulation of endothelial cell migration, regulation of sprouting angiogenesis. Function: protein-cysteine S-palmitoyltransferase activity, glutamine synthetase activity, identical protein binding, transferase activity. Component: extracellular exosome, glial cell projection, plasma membrane, mitochondrion. Beta: 0.01. | cg04301102 (chr5:132777449, -, CpG Island). In SEPTIN8 (septin 8) body, 30kbp downstream of TSS. Process: regulation of intracellular protein transport, regulation of SNARE complex assembly, cytoskeleton-dependent cytokinesis, intracellular protein localization. Function: molecular adaptor activity, nucleotide binding, GTPase activity, protein binding. Component: synaptic vesicle membrane, microtubule cytoskeleton, cytoplasmic vesicle, cell division site. Beta: 0.01. | cg04528217 (chr6:32154707, +, CpG Island). In ENSG00000285085 promoter, 334bp upstream of TSS; PPT2-EGFL8 (PPT2-EGFL8 readthrough (NMD candidate)) body (exon_2), 862bp downstream of TSS. Beta: 0.01. | cg04689080 (chr22:45867327, +, CpG Island). Intergenic. Beta: 0.01. | cg05369142 (chr3:46693519, -, CpG Island). In ALS2CL (ALS2 C-terminal like) body (intron_1), 552bp downstream of TSS; TMIE (transmembrane inner ear) promoter, 1kbp upstream of TSS. Process: endosomal transport. Function: GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding. Component: cytoplasm, cytoplasmic vesicle, cytosol. Process: inner ear morphogenesis, sensory perception of sound. Component: membrane. Beta: 0.01. | cg05875700 (chr8:688208, +, CpG Island). In ERICH1 (glutamate rich 1) body (intron_3), 50kbp downstream of TSS. Function: protein binding. Beta: 0.01. | cg05890887 (chr4:39458979, +, CpG Island). In LIAS (lipoic acid synthetase) promoter, 25bp upstream of TSS; RPL9 (ribosomal protein L9) promoter, 31bp upstream of TSS. Process: response to lipopolysaccharide, lipoate biosynthetic process, inflammatory response, protein lipoylation. Function: 4 iron, 4 sulfur cluster binding, sulfurtransferase activity, lipoate synthase activity, transferase activity. Component: mitochondrial matrix, mitochondrion. Process: negative regulation of myoblast fusion, striated muscle contraction, cytoplasmic translation, spermatogenesis. Function: RNA binding, protein binding, rRNA binding, structural constituent of ribosome. Component: cytosolic large ribosomal subunit, ribonucleoprotein complex, endoplasmic reticulum, cytosolic ribosome. Beta: 0.01. | cg06213463 (chr16:56589303, -, CpG Island). In MT3 (metallothionein 3) body, 229bp downstream of TSS. Process: positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of hydrogen peroxide catabolic process, negative regulation of neuron projection development, cellular response to reactive oxygen species. Function: protein kinase activator activity, antioxidant activity, cadmium ion binding, protein binding. Component: perinuclear region of cytoplasm, mitochondrial outer membrane, astrocyte projection, extracellular space. Beta: 0.01. | cg06799298 (chr17:4143054, +, CpG Island). In CYB5D2 (cytochrome b5 domain containing 2) promoter, 114bp upstream of TSS; ZZEF1 (zinc finger ZZ-type and EF-hand domain containing 1) body, 574bp downstream of TSS. Process: nervous system development. Function: heme binding, protein binding, steroid binding. Component: endomembrane system, extracellular region, membrane. Function: calcium ion binding, histone binding, protein binding, metal ion binding. Beta: 0.01. | cg07063853 (chr11:43311962, -, CpG Island). In API5 (apoptosis inhibitor 5) body, 7bp downstream of TSS. Process: apoptotic process, negative regulation of apoptotic process. Function: RNA binding, fibroblast growth factor binding, protein binding. Component: spliceosomal complex, nuclear speck, cytoplasm, membrane. Beta: 0.01. | cg07910813 (chr18:67516508, +, CpG Island). In DSEL (dermatan sulfate epimerase like) body (exon_1), 215bp downstream of TSS; DSEL-AS1 promoter, 38bp upstream of TSS. Process: chondroitin sulfate proteoglycan metabolic process, dermatan sulfate proteoglycan biosynthetic process, dermatan sulfate proteoglycan metabolic process. Function: chondroitin-glucuronate 5-epimerase activity, isomerase activity, sulfotransferase activity. Component: Golgi membrane, membrane. Beta: 0.01. | cg08475931 (chr7:30594777, -, CpG Island). In GARS1 (glycyl-tRNA synthetase 1) body, 14kbp downstream of TSS; GARS1-DT body, 509bp downstream of TSS. Process: diadenosine tetraphosphate biosynthetic process, tRNA aminoacylation for protein translation, mitochondrial glycyl-tRNA aminoacylation, glycyl-tRNA aminoacylation. Function: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity, ATP:ATP adenylyltransferase activity, aminoacyl-tRNA ligase activity, protein dimerization activity. Component: extracellular exosome, extracellular region, mitochondrial matrix, secretory granule. Beta: 0.01. | cg08872494 (chr1:113905172, +, CpG Island). In AP4B1 (adaptor related protein complex 4 subunit beta 1) body, 550bp downstream of TSS; DCLRE1B (DNA cross-link repair 1B) body, 769bp downstream of TSS. Process: protein localization to somatodendritic compartment, intracellular protein transport, vesicle-mediated transport, protein targeting. Function: clathrin binding, protein binding. Component: cytoplasmic side of trans-Golgi network transport vesicle membrane, clathrin adaptor complex, Golgi apparatus, endosome lumen. Process: double-strand break repair via nonhomologous end joining, protection from non-homologous end joining at telomere, telomere maintenance via telomere lengthening, telomeric 3' overhang formation. Function: protein-containing complex binding, protein homodimerization activity, 5'-3' DNA exonuclease activity, beta-lactamase activity. Component: chromosome, telomeric region, nuclear body, nucleoplasm, centrosome. Beta: 0.01. | cg08989932 (chr10:63630766, +, CpG Island). In ENSG00000286373 body (exon_1), 520bp downstream of TSS; ENSG00000307521 promoter, 714bp upstream of TSS. Beta: 0.01. | cg09037581 (chr20:62861825, +, CpG Island). In TCFL5 (transcription factor like 5) body, at TSS; ENSG00000302953 body (intron_1), 429bp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, regulation of cell population proliferation, cell differentiation, spermatogenesis. Function: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, protein dimerization activity. Component: chromatin, male germ cell nucleus, nucleoplasm, nucleus. Beta: 0.01. | cg09892203 (chr17:66965024, +, CpG Island). In CACNG4 (calcium voltage-gated channel auxiliary subunit gamma 4) body (exon_1), 317bp downstream of TSS; ENSG00000289877 promoter, 460bp upstream of TSS. Process: positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of synaptic transmission, glutamatergic, postsynaptic neurotransmitter receptor diffusion trapping, monoatomic ion transmembrane transport. Function: voltage-gated calcium channel activity, ionotropic glutamate receptor binding, protein binding, calcium channel regulator activity. Component: L-type voltage-gated calcium channel complex, AMPA glutamate receptor complex, monoatomic ion channel complex, postsynaptic density membrane. Beta: 0.01. | cg09969830 (chr16:53646, +, CpG Island). In POLR3K (RNA polymerase III subunit K) body, 12bp downstream of TSS; SNRNP25 (small nuclear ribonucleoprotein U11/U12 subunit 25) promoter, 182bp upstream of TSS. Process: transcription initiation at RNA polymerase III promoter, DNA-templated transcription, defense response to virus, innate immune response. Function: DNA-directed RNA polymerase activity, metal ion binding, nucleic acid binding, zinc ion binding. Component: DNA-directed RNA polymerase complex, nucleoplasm, cytosol, nucleus. Process: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosome conformational change to release U4 (or U4atac) and U1 (or U11). Function: protein binding. Component: U12-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex. Beta: 0.01. | cg12477533 (chr2:98086987, -, CpG Island). In VWA3B (von Willebrand factor A domain containing 3B) promoter, 129bp upstream of TSS. Component: cytoplasm, cytosol. Beta: 0.01. | cg12487497 (chr15:34337794, -, CpG Island). In SLC12A6 (solute carrier family 12 member 6) body, 266bp downstream of TSS; ENSG00000299794 promoter, 34bp upstream of TSS. Process: potassium ion import across plasma membrane, cellular response to glucose stimulus, potassium ion transmembrane transport, cellular hypotonic salinity response. Function: potassium ion transmembrane transporter activity, chloride:monoatomic cation symporter activity, protein kinase binding, metal ion binding. Component: basolateral plasma membrane, synapse, axon, apical plasma membrane. Beta: 0.01. | cg12600418 (chr1:37474322, -, CpG Island). In ZC3H12A (zinc finger CCCH-type containing 12A) promoter, 174bp upstream of TSS; LITATS1 body (exon_1), 110bp downstream of TSS. Process: negative regulation of cytokine production involved in inflammatory response, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, negative regulation of non-canonical NF-kappaB signal transduction, positive regulation of reactive oxygen species metabolic process. Function: cysteine-type deubiquitinase activity, mRNA 3'-UTR AU-rich region binding, RNA endonuclease activity, RNA stem-loop binding. Component: cytoplasmic ribonucleoprotein granule, rough endoplasmic reticulum membrane, protein-containing complex, cytoskeleton. Beta: 0.01. | cg12832498 (chr13:110706180, +, CpG Island). In CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial) body, 7kbp downstream of TSS. Process: cysteinyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation. Function: aminoacyl-tRNA ligase activity, nucleotide binding, metal ion binding, ATP binding. Component: cytoplasm, mitochondrion. Beta: 0.01. | cg13685727 (chr9:87974615, -, CpG Island). In CDK20 (cyclin dependent kinase 20) body, 149bp downstream of TSS; ENSG00000303962 body (exon_1), 8bp downstream of TSS. Process: cell division, regulation of cell cycle. Function: cyclin-dependent protein serine/threonine kinase activity, transferase activity, nucleotide binding, protein binding. Component: cilium, cytoplasm, nucleoplasm, nucleus. Beta: 0.01. | cg13724379 (chr3:187739926, +, N_Shore 18bp). In BCL6 (BCL6 transcription repressor) body (intron_1), 6kbp downstream of TSS. Process: negative regulation of mitotic cell cycle DNA replication, negative regulation of transcription by RNA polymerase II, positive regulation of regulatory T cell differentiation, regulation of leukocyte cell-cell adhesion. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, identical protein binding. Component: nucleoplasm, nucleus, paraspeckles, replication fork. Beta: 0.01. | cg17473923 (chr12:89351701, +, CpG Island). In DUSP6 (dual specificity phosphatase 6) body (exon_1), 800bp downstream of TSS; ENSG00000274021 body (exon_1), 686bp downstream of TSS. Process: negative regulation of ERK1 and ERK2 cascade, positive regulation of apoptotic process, peptidyl-tyrosine dephosphorylation, response to xenobiotic stimulus. Function: MAP kinase tyrosine/serine/threonine phosphatase activity, protein tyrosine/threonine phosphatase activity, hydrolase activity, protein binding. Component: cytoplasm, cytosol, nucleoplasm. Beta: 0.01. | cg17491548 (chr2:73385761, +, CpG Island). In ALMS1 (ALMS1 centrosome and basal body associated protein) body, 3bp downstream of TSS; ENSG00000285068 promoter, 70bp upstream of TSS. Process: endosomal transport, positive regulation of cold-induced thermogenesis, regulation of centriole replication, regulation of stress fiber assembly. Function: protein binding. Component: microtubule cytoskeleton, ciliary basal body, spindle pole, centrosome. Beta: 0.01. | cg17942639 (chr2:153478670, -, CpG Island). In RPRM (reprimo, TP53 dependent G2 arrest mediator homolog) body (exon_1), 92bp downstream of TSS; ENSG00000301085 body (intron_3), 845bp downstream of TSS. Process: regulation of cell cycle, regulation of mitotic cell cycle. Function: protein binding. Component: cytoplasm, membrane. Beta: 0.01. | cg17989428 (chr2:20052064, -, CpG Island). In LAPTM4A (lysosomal protein transmembrane 4 alpha) promoter, 371bp upstream of TSS; LAPTM4A-DT body, 264bp downstream of TSS. Process: regulation of lysosomal membrane permeability. Function: protein binding. Component: late endosome membrane, endomembrane system, lysosomal membrane, Golgi apparatus. Beta: 0.01. | cg19389001 (chr3:122921931, +, CpG Island). In SEMA5B (semaphorin 5B) body (exon_12), 107kbp downstream of TSS. Process: positive regulation of cell migration, semaphorin-plexin signaling pathway, neural crest cell migration, nervous system development. Function: chemorepellent activity, semaphorin receptor binding. Component: cytosol, membrane, plasma membrane. Beta: 0.01. | cg19631443 (chr10:28532301, +, CpG Island). In WAC (WW domain containing adaptor with coiled-coil) promoter, 192bp upstream of TSS; WAC-AS1 body (intron_1), 765bp downstream of TSS. Process: negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of DNA-templated transcription, mitotic G1 DNA damage checkpoint signaling, chromatin organization. Function: RNA polymerase II complex binding, chromatin binding, protein binding. Component: nuclear speck, nucleoplasm, nucleus, spliceosomal complex. Beta: 0.01. | cg20489026 (chr1:160084141, +, CpG Island). In KCNJ9 (potassium inwardly rectifying channel subfamily J member 9) body (exon_2), 3kbp downstream of TSS. Process: regulation of presynaptic membrane potential, potassium ion import across plasma membrane, monoatomic ion transmembrane transport, monoatomic ion transport. Function: G-protein activated inward rectifier potassium channel activity, inward rectifier potassium channel activity, ligand-gated monoatomic cation channel activity, protein binding. Component: inward rectifier potassium channel complex, parallel fiber to Purkinje cell synapse, monoatomic ion channel complex, presynaptic membrane. Beta: 0.01. | cg20496693 (chr7:1137999, +, CpG Island). In CHLSN (cholesin) body (exon_1), 314bp downstream of TSS. Process: negative regulation of cholesterol biosynthetic process, signal transduction. Function: RNA binding, hormone activity, protein binding. Component: extracellular region, extracellular space. Beta: 0.01. | cg20603637 (chr8:42152624, -, CpG Island). In AP3M2 (adaptor related protein complex 3 subunit mu 2) promoter, 322bp upstream of TSS; ENSG00000261449 body (exon_1), 139bp downstream of TSS. Process: clathrin-coated vesicle cargo loading, AP-3-mediated, anterograde synaptic vesicle transport, intracellular protein transport, Golgi to vacuole transport. Function: AP-3 adaptor complex binding, clathrin-cargo adaptor activity, protein binding. Component: AP-type membrane coat adaptor complex, cytoplasmic vesicle membrane, glutamatergic synapse, trans-Golgi network. Beta: 0.01. | cg21826815 (chr12:116881027, +, CpG Island). In HRK (harakiri, BCL2 interacting protein) body (exon_1), 414bp downstream of TSS; ENSG00000297968 body (intron_1), 2kbp downstream of TSS. Process: positive regulation of release of cytochrome c from mitochondria, positive regulation of protein-containing complex assembly, positive regulation of neuron apoptotic process, cellular response to potassium ion starvation. Function: protein binding. Component: membrane, mitochondrion. Beta: 0.01. | cg22521356 (chr7:25180357, -, CpG Island). In SPMIP4 (sperm microtubule inner protein 4) promoter, 1bp upstream of TSS; ENSG00000296268 body (intron_3), 155kbp downstream of TSS. Function: protein binding. Component: centrosome. Beta: 0.01. | cg22813794 (chr7:76048151, +, CpG Island). In MDH2 (malate dehydrogenase 2) body (exon_1), 101bp downstream of TSS; STYXL1 (serine/threonine/tyrosine interacting like 1) body, 658bp downstream of TSS. Process: carboxylic acid metabolic process, malate-aspartate shuttle, tricarboxylic acid cycle, aerobic respiration. Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, L-malate dehydrogenase (NADP+) activity, identical protein binding, oxidoreductase activity. Component: extracellular exosome, mitochondrial matrix, mitochondrion, cytoplasm. Process: positive regulation of intrinsic apoptotic signaling pathway, positive regulation of neuron projection development, negative regulation of stress granule assembly, intracellular signal transduction. Function: phosphatase inhibitor activity, protein binding, protein phosphatase binding, pseudophosphatase activity. Component: mitochondrial matrix, mitochondrion. Beta: 0.01. | cg23878564 (chr17:7384130, +, CpG Island). In TNK1 (tyrosine kinase non receptor 1) body (exon_6), 4kbp downstream of TSS. Process: protein autophosphorylation, protein phosphorylation. Function: non-membrane spanning protein tyrosine kinase activity, transferase activity, nucleotide binding, protein binding. Component: cytoplasm, membrane, plasma membrane. Beta: 0.01. | cg24187352 (chr11:356313, +, CpG Island). Intergenic. Beta: 0.01. | cg26005578 (chr11:13009129, -, CpG Island). In RASSF10 (Ras association domain family member 10) promoter, 187bp upstream of TSS; RASSF10-DT body (exon_1), 30bp downstream of TSS. Process: nervous system development, positive regulation of neural precursor cell proliferation, positive regulation of neurogenesis, signal transduction. Function: protein binding. Component: centrosome, cytosol, spindle pole. Beta: 0.01. | cg00108164 (chr2:264199, +, CpG Island). In ACP1 (acid phosphatase 1) body, 59bp downstream of TSS; SH3YL1 (SH3 and SYLF domain containing 1) body, 2kbp downstream of TSS. Process: chemical synaptic transmission. Function: non-membrane spanning protein tyrosine phosphatase activity, SH3 domain binding, hydrolase activity, protein binding. Component: cytoplasmic side of plasma membrane, extracellular exosome, sarcolemma, cytoplasm. Process: regulation of ruffle assembly. Function: phosphatase binding, phosphatidylinositol binding, protein binding. Component: ruffle membrane. Beta: 0.02. | cg00261781 (chr2:20012756, +, CpG Island). In MATN3 (matrilin 3) promoter, 87bp upstream of TSS. Process: extracellular matrix organization, skeletal system development. Function: calcium ion binding, extracellular matrix structural constituent, protein binding. Component: endoplasmic reticulum lumen, extracellular matrix, extracellular region. Beta: 0.02. | cg00287370 (chr1:234600346, -, CpG Island). In ENSG00000309433 body (exon_1), 88bp downstream of TSS; ENSG00000289057 promoter, 289bp upstream of TSS. Beta: 0.02. | cg00401091 (chr20:51542997, -, S_Shore 27bp). In NFATC2 (nuclear factor of activated T cells 2) body, 20kbp downstream of TSS; ENSG00000304242 body (intron_1), 152bp downstream of TSS. Process: negative regulation of vascular associated smooth muscle cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of B cell proliferation, calcineurin-NFAT signaling cascade. Function: DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, molecular adaptor activity. Component: transcription regulator complex, ribonucleoprotein complex, nucleoplasm, chromatin. Beta: 0.02. | cg00770871 (chr12:2890674, +, CpG Island). In TULP3 (TUB like protein 3) body, 13kbp downstream of TSS. Process: regulation of G protein-coupled receptor signaling pathway, protein localization to non-motile cilium, regulation of DNA-templated transcription, intraciliary anterograde transport. Function: phosphatidylinositol-4,5-bisphosphate binding, intraciliary transport particle A binding, protein-macromolecule adaptor activity, G protein-coupled receptor binding. Component: ciliary transition zone, 9+0 non-motile cilium, extracellular region, plasma membrane. Beta: 0.02. | cg00870265 (chr19:912831, +, CpG Island). In R3HDM4 (R3H domain containing 4) body (intron_1), 414bp downstream of TSS. Function: nucleic acid binding. Component: nucleus. Beta: 0.02. | cg01044608 (chr19:57320466, -, CpG Island). In ZNF543 (zinc finger protein 543) promoter, 6bp upstream of TSS. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Component: nucleus. Beta: 0.02. | cg01077609 (chr1:88684361, +, CpG Island). In PKN2 (protein kinase N2) body (exon_1), 139bp downstream of TSS; PKN2-AS1 body, 1kbp downstream of TSS. Process: vascular endothelial cell response to laminar fluid shear stress, positive regulation of viral genome replication, positive regulation of mitotic cell cycle, intracellular signal transduction. Function: diacylglycerol-dependent serine/threonine kinase activity, protein tyrosine kinase activity, histone deacetylase binding, RNA polymerase binding. Component: intermediate filament cytoskeleton, perinuclear region of cytoplasm, protein-containing complex, apical junction complex. Beta: 0.02. | cg01185855 (chr3:9933824, -, CpG Island). In CRELD1 (CRELD disulfide isomerase 1) body, 31bp downstream of TSS; ENSG00000288550 body (intron_16), 17kbp downstream of TSS. Process: cardiac septum development, endocardial cushion development. Function: extracellular matrix structural constituent, protein disulfide isomerase activity, calcium ion binding, protein binding. Component: glutamatergic synapse, extracellular matrix, extracellular space, membrane. Beta: 0.02. | cg01391867 (chr7:99500248, +, CpG Island). In ZKSCAN5 (zinc finger with KRAB and SCAN domains 5) promoter, 150bp upstream of TSS; ZNF394 (zinc finger protein 394) body (exon_1), 5kbp downstream of TSS. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, DNA-binding transcription factor activity. Component: nucleus. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Component: nucleoplasm, nucleus. Beta: 0.02. | cg01446983 (chr17:49677614, +, CpG Island). In SPOP (speckle type BTB/POZ protein) body (intron_1), 587bp downstream of TSS. Process: proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of proteolysis. Function: identical protein binding, molecular function inhibitor activity, protein binding, ubiquitin protein ligase binding. Component: Cul3-RING ubiquitin ligase complex, nuclear speck, nucleoplasm, cytoplasm. Beta: 0.02. | cg01509843 (chr8:142614461, -, CpG Island). In ARC (activity regulated cytoskeleton associated protein) body (exon_1), 18bp downstream of TSS; ENSG00000277332 promoter, 265bp upstream of TSS. Process: regulation of postsynaptic neurotransmitter receptor internalization, regulation of long-term synaptic potentiation, modulation of chemical synaptic transmission, regulation of dendritic spine morphogenesis. Function: RNA binding, mRNA binding, protein binding, structural molecule activity. Component: neuronal ribonucleoprotein granule, clathrin-coated vesicle membrane, early endosome membrane, extracellular vesicle. Beta: 0.02. | cg01532168 (chr8:139703314, +, CpG Island). In KCNK9 (potassium two pore domain channel subfamily K member 9) body, 795bp downstream of TSS; ENSG00000296434 body (intron_1), 682bp downstream of TSS. Process: negative regulation of aldosterone secretion, potassium ion import across plasma membrane, regulation of action potential firing rate, monoatomic ion transmembrane transport. Function: outward rectifier potassium channel activity, protein heterodimerization activity, identical protein binding, metal ion binding. Component: mitochondrial inner membrane, synaptic vesicle, plasma membrane, dendrite. Beta: 0.02. | cg01619129 (chr8:10839507, +, CpG Island). In PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1) body (intron_1), 377bp downstream of TSS; PINX1-DT body, 401bp downstream of TSS. Process: negative regulation of telomere maintenance via telomere lengthening, negative regulation of G2/M transition of mitotic cell cycle, positive regulation of protein localization to nucleolus, protein localization to chromosome, telomeric region. Function: protein-containing complex binding, telomerase inhibitor activity, telomerase RNA binding, nucleic acid binding. Component: chromosome, telomeric region, nuclear chromosome, kinetochore, nucleoplasm. Beta: 0.02. | cg01639032 (chr6:31815252, -, CpG Island). In HSPA1A (heat shock protein family A (Hsp70) member 1A) promoter, 291bp upstream of TSS; HSPA1L (heat shock protein family A (Hsp70) member 1 like) body (exon_1), 536bp downstream of TSS. Process: negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Function: ATP-dependent protein disaggregase activity, transcription regulator inhibitor activity, C3HC4-type RING finger domain binding, G protein-coupled receptor binding. Component: perinuclear region of cytoplasm, ficolin-1-rich granule lumen, protein-containing complex, ribonucleoprotein complex. Process: positive regulation of protein localization to mitochondrion, protein refolding, response to stress, response to unfolded protein. Function: ubiquitin protein ligase binding, heat shock protein binding, protein folding chaperone, ATP hydrolysis activity. Component: zona pellucida receptor complex, blood microparticle, COP9 signalosome, plasma membrane. Beta: 0.02. | cg01823956 (chr14:101761873, +, CpG Island). In PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma) body (exon_1), 191bp downstream of TSS; ENSG00000289049 promoter, 388bp upstream of TSS. Process: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, proteasome-mediated ubiquitin-dependent protein catabolic process, negative regulation of cell population proliferation, meiotic sister chromatid cohesion. Function: protein binding, protein phosphatase activator activity, protein phosphatase regulator activity. Component: protein phosphatase type 2A complex, chromosome, centromeric region, nucleoplasm, cytosol. Beta: 0.02. | cg01845244 (chr6:7911007, +, CpG Island). In TXNDC5 (thioredoxin domain containing 5) body, 4bp downstream of TSS; BLOC1S5-TXNDC5 (BLOC1S5-TXNDC5 readthrough (NMD candidate)) body (intron_4), 153kbp downstream of TSS. Process: negative regulation of apoptotic process, protein folding. Function: protein disulfide isomerase activity, protein-disulfide reductase activity, oxidoreductase activity, protein binding. Component: intracellular organelle lumen, endoplasmic reticulum lumen, azurophil granule lumen, extracellular exosome. Beta: 0.02. | cg01956624 (chr2:231037701, -, CpG Island). In C2orf72 (chromosome 2 open reading frame 72) body (exon_1), 359bp downstream of TSS. Beta: 0.02. | cg01971089 (chr19:4400706, -, CpG Island). In SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2) promoter, 159bp upstream of TSS. Process: central nervous system development, synaptic vesicle endocytosis, membrane organization, signal transduction. Function: protein-macromolecule adaptor activity, identical protein binding, cadherin binding, lipid binding. Component: early endosome membrane, glutamatergic synapse, presynapse, cytoplasm. Beta: 0.02. | cg02189786 (chr16:67842056, +, CpG Island). In THAP11 (THAP domain containing 11) promoter, 264bp upstream of TSS; CENPT (centromere protein T) body (intron_1), 6kbp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, metal ion binding, protein binding. Component: chromatin, cytoplasm, nucleoplasm, nucleus. Process: chromosome organization, chromosome segregation, kinetochore assembly, mitotic cell cycle. Function: DNA binding, protein binding, protein heterodimerization activity. Component: chromosome, centromeric region, nuclear body, kinetochore, nucleoplasm. Beta: 0.02. | cg02331561 (chr16:2341080, +, CpG Island). In ABCA3 (ATP binding cassette subfamily A member 3) promoter, 331bp upstream of TSS; ABCA17P body (exon_1), 2kbp downstream of TSS. Process: regulation of phosphatidylcholine metabolic process, positive regulation of protein homooligomerization, xenobiotic transmembrane transport, response to xenobiotic stimulus. Function: ATPase-coupled intramembrane lipid transporter activity, ABC-type xenobiotic transporter activity, phosphatidylcholine flippase activity, ATP hydrolysis activity. Component: intracellular membrane-bounded organelle, alveolar lamellar body membrane, cytoplasmic vesicle membrane, late endosome membrane. Beta: 0.02. | cg02403541 (chr12:121016485, +, CpG Island). In C12orf43 (chromosome 12 open reading frame 43) body (exon_1), 19bp downstream of TSS. Process: Spemann organizer formation, Wnt signaling pathway, negative regulation of Wnt signaling pathway. Function: protein binding. Component: nuclear envelope, nucleolus. Beta: 0.02. | cg02444300 (chr19:48110574, -, OpenSea). In PLA2G4C (phospholipase A2 group IVC) body (exon_1), 276bp downstream of TSS. Process: platelet activating factor biosynthetic process, phosphatidylethanolamine acyl-chain remodeling, glycerophospholipid catabolic process, intracellular signal transduction. Function: phosphatidylcholine lysophospholipase A1 activity, glycerophospholipid phospholipase A1 activity, calcium-dependent phospholipid binding, A2-type glycerophospholipase activity. Component: endoplasmic reticulum membrane, mitochondrial membrane, nuclear envelope, plasma membrane. Beta: 0.02. | cg02712555 (chr20:54174194, -, CpG Island). In CYP24A1 (cytochrome P450 family 24 subfamily A member 1) promoter, 208bp upstream of TSS; ENSG00000286587 body (intron_3), 115kbp downstream of TSS. Process: calcitriol biosynthetic process from calciol, vitamin D receptor signaling pathway, small molecule biosynthetic process, cellular response to vitamin D. Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity, 25-hydroxycholecalciferol-23-hydroxylase activity, 25-hydroxycholecalciferol-24-hydroxylase activity. Component: mitochondrial inner membrane, mitochondrion. Beta: 0.02. | cg02728595 (chr3:196528761, -, CpG Island). In NAA50P2 body (exon_1), 30bp downstream of TSS; ENSG00000308888 promoter, 224bp upstream of TSS. Beta: 0.02. | cg02810156 (chr19:36331770, +, CpG Island). In LINC00665 body, at TSS. Beta: 0.02. | cg02848777 (chr10:96513957, -, CpG Island). In TLL2 (tolloid like 2) promoter, 16bp upstream of TSS. Process: dorsal/ventral pattern formation, collagen fibril organization, cell differentiation, protein processing. Function: serine-type endopeptidase activity, metalloendopeptidase activity, metallopeptidase activity, calcium ion binding. Component: extracellular region, extracellular space. Beta: 0.02. | cg02853322 (chr7:39950124, -, CpG Island). In CDK13 (cyclin dependent kinase 13) body, 3bp downstream of TSS; CDK13-DT promoter, 147bp upstream of TSS. Process: positive regulation of transcription elongation by RNA polymerase II, alternative mRNA splicing, via spliceosome, regulation of signal transduction, regulation of cell cycle. Function: RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activity, transferase activity, nucleotide binding. Component: cyclin/CDK positive transcription elongation factor complex, nuclear cyclin-dependent protein kinase holoenzyme complex, ficolin-1-rich granule lumen, cyclin K-CDK13 complex. Beta: 0.02. | cg02991799 (chr19:34677605, -, CpG Island). In SCGB2B2 (secretoglobin family 2B member 2) promoter, 446bp upstream of TSS; ZNF302 (zinc finger protein 302) body, 521bp downstream of TSS. Function: protein binding. Component: extracellular region. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Component: nucleus. Beta: 0.02. | cg03054303 (chr16:1612300, -, CpG Island). In CRAMP1 (cramped chromatin regulator 1) promoter, 37bp upstream of TSS; IFT140 (intraflagellar transport 140) promoter, 225bp upstream of TSS. Process: pattern specification process, positive regulation of DNA-templated transcription. Function: DNA binding, DNA-binding transcription factor activity, chromatin binding. Component: chromosome, histone locus body, nucleus. Process: protein localization to non-motile cilium, intraciliary anterograde transport, regulation of cilium assembly, cell projection organization. Function: protein binding, protein carrier chaperone. Component: intraciliary transport particle A, photoreceptor connecting cilium, photoreceptor outer segment, ciliary basal body. Beta: 0.02. | cg03098356 (chr6:87155596, -, CpG Island). In ZNF292 (zinc finger protein 292) body (exon_1), 4kbp downstream of TSS; ENSG00000272008 promoter, 105bp upstream of TSS. Process: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription activator activity, RNA polymerase II-specific, metal ion binding, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific. Component: nucleus. Beta: 0.02. | cg03110633 (chr19:35000361, -, CpG Island). In GRAMD1A (GRAM domain containing 1A) body (exon_1), 6kbp downstream of TSS; GRAMD1A-AS1 promoter, 146bp upstream of TSS. Process: autophagy, intracellular cholesterol transport, intracellular sterol transport, lipid transport. Function: cholesterol binding, cholesterol transfer activity, lipid binding, protein binding. Component: endoplasmic reticulum-plasma membrane contact site, cytoplasmic vesicle, plasma membrane, autophagosome. Beta: 0.02. | cg03208951 (chr19:48325578, +, S_Shelf 3342bp). In EMP3 (epithelial membrane protein 3 (MAM blood group)) body (exon_1), 4kbp downstream of TSS. Process: apoptotic process, bleb assembly. Function: protein binding. Component: membrane, plasma membrane. Beta: 0.02. | cg03274876 (chr4:169757855, +, CpG Island). In HPF1 (histone PARylation factor 1) body (exon_1), 89bp downstream of TSS; ENSG00000295852 promoter, 160bp upstream of TSS. Process: DNA repair-dependent chromatin remodeling, regulation of protein ADP-ribosylation, double-strand break repair, DNA damage response. Function: protein ADP-ribosyltransferase-substrate adaptor activity, poly-ADP-D-ribose binding, chromatin binding, histone binding. Component: chromatin, chromosome, nucleus, site of DNA damage. Beta: 0.02. | cg03306486 (chr19:1467953, +, CpG Island). In C19orf25 (chromosome 19 open reading frame 25) body, 12kbp downstream of TSS; APC2 (APC regulator of Wnt signaling pathway 2) body (exon_15), 22kbp downstream of TSS. Function: protein binding. Process: proteasome-mediated ubiquitin-dependent protein catabolic process, negative regulation of canonical Wnt signaling pathway, microtubule cytoskeleton organization, activation of GTPase activity. Function: beta-catenin binding, gamma-catenin binding, microtubule binding, protein binding. Component: plasma membrane bounded cell projection, beta-catenin destruction complex, perinuclear region of cytoplasm, microtubule cytoskeleton. Beta: 0.02. | cg03527353 (chr11:31811166, +, CpG Island). In ENSG00000285283 promoter, 1kbp upstream of TSS; PAX6 (paired box 6) body (exon_1), 7kbp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, positive regulation of gene expression, type B pancreatic cell differentiation, cornea development in camera-type eye. Function: DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, histone acetyltransferase binding. Component: chromatin, cytoplasm, nucleoplasm, nucleus. Beta: 0.02. | cg03603214 (chr1:48777085, +, CpG Island). In BEND5 (BEN domain containing 5) promoter, 116bp upstream of TSS; AGBL4 (AGBL carboxypeptidase 4) body (intron_6), 1247kbp downstream of TSS. Process: negative regulation of DNA-templated transcription. Function: DNA binding, protein binding. Component: Golgi apparatus. Process: defense response to virus, proteolysis. Function: metallocarboxypeptidase activity, carboxypeptidase activity, metallopeptidase activity, hydrolase activity. Component: microtubule cytoskeleton, ciliary basal body, Golgi apparatus, centriole. Beta: 0.02. | cg03607359 (chr5:176630464, -, CpG Island). In EIF4E1B (eukaryotic translation initiation factor 4E family member 1B) promoter, 118bp upstream of TSS; SNCB (synuclein beta) body (exon_1), 208bp downstream of TSS. Process: regulation of translation, translation, translational initiation. Function: RNA 7-methylguanosine cap binding, RNA binding, protein binding, translation initiation factor activity. Component: cytoplasm, eukaryotic translation initiation factor 4F complex. Process: chemical synaptic transmission, synapse organization, synaptic vesicle endocytosis. Function: phospholipase inhibitor activity, transition metal ion binding, protein binding, calcium ion binding. Component: neuronal cell body, inclusion body, axon terminus, cytoplasm. Beta: 0.02. | cg03778669 (chr6:28489469, -, OpenSea). In ENSG00000287804 body (exon_1), 48bp downstream of TSS; ENSG00000286819 promoter, 110bp upstream of TSS. Beta: 0.02. | cg03848555 (chr9:74952445, -, CpG Island). In C9orf40 (chromosome 9 open reading frame 40) body (exon_1), 467bp downstream of TSS; CARNMT1-AS1 promoter, 523bp upstream of TSS. Beta: 0.02. | cg03965044 (chr17:50634851, -, CpG Island). In ABCC3 (ATP binding cassette subfamily C member 3) body, 242bp downstream of TSS; ENSG00000251239 body (intron_1), 4kbp downstream of TSS. Process: transport across blood-brain barrier, xenobiotic transmembrane transport, bile acid and bile salt transport, xenobiotic metabolic process. Function: ABC-type glutathione S-conjugate transporter activity, ATPase-coupled transmembrane transporter activity, ATP hydrolysis activity, nucleotide binding. Component: basal plasma membrane, basolateral plasma membrane, membrane, plasma membrane. Beta: 0.02. | cg04154825 (chr3:122564405, +, CpG Island). In DTX3L (deltex E3 ubiquitin ligase 3L) body (exon_1), 67bp downstream of TSS; PARP9 (poly(ADP-ribose) polymerase family member 9) body, 1kbp downstream of TSS. Process: negative regulation of ubiquitin-protein transferase activity, positive regulation of protein localization to early endosome, positive regulation of defense response to virus by host, positive regulation of receptor catabolic process. Function: protein ADP-ribosyltransferase-substrate adaptor activity, histone H4K91 ubiquitin ligase activity, ubiquitin-protein transferase activity, ubiquitin-like protein ligase binding. Component: protein-containing complex, early endosome membrane, lysosomal membrane, nucleoplasm. Process: positive regulation of type II interferon-mediated signaling pathway, positive regulation of tyrosine phosphorylation of STAT protein, negative regulation of transcription by RNA polymerase II, positive regulation of defense response to virus by host. Function: NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity, NAD+ poly-ADP-ribosyltransferase activity, ubiquitin-like protein ligase binding, transcription corepressor activity. Component: protein-containing complex, site of DNA damage, nucleoplasm, cytoplasm. Beta: 0.02. | cg04232649 (chr5:163437483, +, CpG Island). In CCNG1 (cyclin G1) promoter, 86bp upstream of TSS; ENSG00000254186 promoter, 46bp upstream of TSS. Process: G1/S transition of mitotic cell cycle, cell division, regulation of cyclin-dependent protein serine/threonine kinase activity. Function: cyclin-dependent protein serine/threonine kinase regulator activity, protein binding. Component: cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleoplasm, nucleus. Beta: 0.02. | cg04490108 (chr1:150364556, -, CpG Island). In RPRD2 (regulation of nuclear pre-mRNA domain containing 2) body (exon_1), 1kbp downstream of TSS. Process: mRNA 3'-end processing. Function: RNA polymerase II C-terminal domain binding, RNA polymerase II complex binding. Component: nucleoplasm, transcription preinitiation complex. Beta: 0.02. | cg04739306 (chr7:100633158, +, CpG Island). In TFR2 (transferrin receptor 2) body (intron_5), 10kbp downstream of TSS. Process: positive regulation of transcription by RNA polymerase II, multicellular organismal-level iron ion homeostasis, positive regulation of peptide hormone secretion, endocytic iron import into cell. Function: co-receptor binding, protein binding, transferrin receptor activity. Component: HFE-transferrin receptor complex, external side of plasma membrane, cytoplasmic vesicle, cytoplasm. Beta: 0.02. | cg04794120 (chr7:47979608, +, CpG Island). In HUS1 (HUS1 checkpoint clamp component) body (exon_1), 74bp downstream of TSS; ENSG00000300483 body (intron_1), 226bp downstream of TSS. Process: double-strand break repair via homologous recombination, embryo development ending in birth or egg hatching, mitotic intra-S DNA damage checkpoint signaling, cellular response to ionizing radiation. Function: protein binding. Component: site of double-strand break, checkpoint clamp complex, nucleoplasm, nucleolus. Beta: 0.02. | cg04845144 (chr19:45496541, +, CpG Island). In RTN2 (reticulon 2) body (intron_1), 514bp downstream of TSS; PPM1N (protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)) body, 8kbp downstream of TSS. Process: endoplasmic reticulum tubular network membrane organization, regulation of D-glucose import across plasma membrane, intracellular protein transmembrane transport, negative regulation of amyloid-beta formation. Function: protein binding. Component: sarcoplasmic reticulum membrane, endoplasmic reticulum, intermediate filament, postsynaptic density. Process: positive regulation of canonical Wnt signaling pathway, regulation of canonical NF-kappaB signal transduction. Function: protein serine/threonine phosphatase activity, magnesium ion binding, hydrolase activity, phosphoprotein phosphatase activity. Component: cytosol, nucleus. Beta: 0.02. | cg04863182 (chr15:81324345, +, CpG Island). In STARD5 (StAR related lipid transfer domain containing 5) promoter, 162bp upstream of TSS; TMC3-AS1 body, 44bp downstream of TSS. Process: bile acid and bile salt transport, cholesterol import, lipid transport. Function: bile acid binding, cholesterol binding, cholesterol transfer activity, lipid binding. Component: cytosol. Beta: 0.02. | cg05003422 (chr1:85048206, +, CpG Island). In MCOLN3 (mucolipin TRP cation channel 3) body (intron_1), 473bp downstream of TSS; DNAI3 (dynein axonemal intermediate chain 3) body, 49kbp downstream of TSS. Process: monoatomic anion transmembrane transport, potassium ion transmembrane transport, calcium-mediated signaling, monoatomic ion transmembrane transport. Function: NAADP-sensitive calcium-release channel activity, monoatomic cation channel activity, lipid binding, monoatomic anion channel activity. Component: early endosome membrane, autophagosome membrane, cytoplasmic vesicle, lysosomal membrane. Process: negative regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of osteoblast differentiation, cilium movement involved in cell motility, inner dynein arm assembly. Function: Arp2/3 complex binding, dynein heavy chain binding, dynein light chain binding, protein binding. Component: axonemal dynein complex, cytoplasm, inner dynein arm. Beta: 0.02. | cg05088677 (chr10:21496804, +, CpG Island). In MIR1915 promoter, 163bp upstream of TSS; MIR1915HG body (exon_1), 456bp downstream of TSS. Beta: 0.02. | cg05189291 (chr5:157731449, -, CpG Island). In THG1L (tRNA-histidine guanylyltransferase 1 like) body (exon_1), 37bp downstream of TSS; ENSG00000309117 body (intron_1), 235bp downstream of TSS. Process: stress-induced mitochondrial fusion, response to oxidative stress, protein homotetramerization, tRNA 5'-end processing. Function: guanyl-nucleotide exchange factor activity, tRNA guanylyltransferase activity, nucleotidyltransferase activity, identical protein binding. Component: mitochondrial outer membrane, transferase complex, mitochondrion, cytoplasm. Beta: 0.02. | cg05492270 (chr11:71929039, -, OpenSea). In RNF121 (ring finger protein 121) body, 21bp downstream of TSS; XNDC1N-ZNF705EP-ALG1L9P (XNDC1N-ZNF705EP-ALG1L9P readthrough) promoter, 383bp upstream of TSS. Process: ERAD pathway, protein ubiquitination. Function: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding. Component: Golgi membrane, endoplasmic reticulum membrane. Beta: 0.02. | cg05496738 (chr2:25878687, +, CpG Island). In ASXL2 (ASXL transcriptional regulator 2) promoter, 200bp upstream of TSS. Process: positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II, positive regulation of fat cell differentiation, animal organ morphogenesis. Function: peroxisome proliferator activated receptor binding, chromatin binding, metal ion binding, protein binding. Component: PR-DUB complex, nucleoplasm, nucleus. Beta: 0.02. | cg05676377 (chr6:26383445, +, OpenSea). In BTN2A2 (butyrophilin subfamily 2 member A2) body (intron_1), 353bp downstream of TSS; ENSG00000291338 body, 226kbp downstream of TSS. Process: T cell receptor signaling pathway, negative regulation of activated T cell proliferation, negative regulation of cytokine production, regulation of cytokine production. Function: protein binding, signaling receptor binding. Component: cell surface, external side of plasma membrane, membrane, plasma membrane. Beta: 0.02. | cg05770238 (chr1:26360096, +, CpG Island). In CRYBG2 (crystallin beta-gamma domain containing 2) promoter, 16bp upstream of TSS. Function: carbohydrate binding. Beta: 0.02. || Highest methylated (100 sites): cg00474840 (chr19:18010010, +, CpG Island). In ARRDC2 (arrestin domain containing 2) body (exon_5), 9kbp downstream of TSS; ENSG00000279172 promoter, 129bp upstream of TSS. Function: molecular adaptor activity, protein binding. Component: cytoplasm, cytoplasmic vesicle, plasma membrane. Beta: 0.99. | cg01495521 (chr16:928040, +, N_Shore 1383bp). In LMF1 (lipase maturation factor 1) body (intron_3), 53kbp downstream of TSS; LMF1-AS1 body (intron_1), 7kbp downstream of TSS. Process: protein maturation, triglyceride metabolic process. Component: endoplasmic reticulum membrane. Beta: 0.99. | cg02399044 (chr12:2391063, +, OpenSea). In CACNA1C (calcium voltage-gated channel subunit alpha1 C) body (intron_3), 420kbp downstream of TSS. Process: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, calcium ion transmembrane transport via high voltage-gated calcium channel, membrane depolarization during atrial cardiac muscle cell action potential, cell communication by electrical coupling involved in cardiac conduction. Function: voltage-gated calcium channel activity involved in cardiac muscle cell action potential, monoatomic ion channel activity, alpha-actinin binding, calmodulin binding. Component: L-type voltage-gated calcium channel complex, monoatomic ion channel complex, postsynaptic density membrane, plasma membrane. Beta: 0.99. | cg03353885 (chr13:112835078, +, S_Shelf 2045bp). In ATP11A (ATPase phospholipid transporting 11A) body (intron_15), 145kbp downstream of TSS; ENSG00000303208 body (intron_1), 2kbp downstream of TSS. Process: positive regulation of myotube differentiation, regulation of membrane lipid distribution, aminophospholipid translocation, phospholipid translocation. Function: ATPase-coupled intramembrane lipid transporter activity, phosphatidylethanolamine flippase activity, phosphatidylserine floppase activity, ATP hydrolysis activity. Component: phospholipid-translocating ATPase complex, endoplasmic reticulum membrane, specific granule membrane, endomembrane system. Beta: 0.99. | cg03483654 (chr11:61334602, -, S_Shore 1102bp). In TKFC (triokinase and FMN cyclase) body (intron_1), 1kbp downstream of TSS; DDB1 (damage specific DNA binding protein 1) body, 8kbp downstream of TSS. Process: fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate, negative regulation of MDA-5 signaling pathway, regulation of innate immune response, carbohydrate metabolic process. Function: FAD-AMP lyase (cyclizing) activity, glycerone kinase activity, transferase activity, triokinase activity. Component: cytosol, extracellular exosome, nucleus. Process: positive regulation by virus of viral protein levels in host cell, proteasome-mediated ubiquitin-dependent protein catabolic process, biological process involved in interaction with symbiont, regulation of DNA-templated DNA replication initiation. Function: ubiquitin ligase complex scaffold activity, protein-macromolecule adaptor activity, protein-containing complex binding, cullin family protein binding. Component: Cul4A-RING E3 ubiquitin ligase complex, chromosome, telomeric region, site of double-strand break, protein-containing complex. Beta: 0.99. | cg04998671 (chr14:103534168, +, N_Shore 383bp). In TRMT61A (tRNA methyltransferase 61A) body (intron_3), 13kbp downstream of TSS. Process: tRNA methylation, mRNA processing, tRNA processing, RNA processing. Function: tRNA (adenine(58)-N1)-methyltransferase activity, mRNA (adenine-N1-)-methyltransferase activity, methyltransferase activity, transferase activity. Component: nucleoplasm, nucleus, tRNA (m1A) methyltransferase complex. Beta: 0.99. | cg05184586 (chr17:42113809, -, N_Shelf 3574bp). In DHX58 (DExH-box helicase 58) promoter, 1kbp upstream of TSS; KAT2A (lysine acetyltransferase 2A) body (exon_18), 8kbp downstream of TSS. Process: cytoplasmic pattern recognition receptor signaling pathway, negative regulation of type I interferon production, negative regulation of MDA-5 signaling pathway, negative regulation of innate immune response. Function: double-stranded RNA binding, ATP hydrolysis activity, RNA helicase activity, hydrolase activity. Component: Golgi apparatus, cytoplasm, cytosol. Process: negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process, positive regulation of cardiac muscle cell differentiation, negative regulation of transcription by RNA polymerase II, cellular response to nerve growth factor stimulus. Function: acyltransferase activity, transferring groups other than amino-acyl groups, histone H1-4K34 acetyltransferase activity, protein-lysine-acetyltransferase activity, DNA-binding transcription factor binding. Component: oxoglutarate dehydrogenase complex, histone acetyltransferase complex, transcription factor TFTC complex, extracellular space. Beta: 0.99. | cg06662140 (chr1:18482803, -, CpG Island). In KLHDC7A (kelch domain containing 7A) body (exon_1), 2kbp downstream of TSS. Function: protein binding. Component: membrane. Beta: 0.99. | cg06845706 (chr22:23391625, +, S_Shelf 3275bp). In CCDC188BP promoter, 928bp upstream of TSS; ENSG00000309931 body (intron_1), 3kbp downstream of TSS. Beta: 0.99. | cg06911753 (chr11:47589684, -, CpG Island). In C1QTNF4 (C1q and TNF related 4) body (exon_2), 6kbp downstream of TSS. Process: positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of interleukin-6-mediated signaling pathway, positive regulation of tumor necrosis factor production, positive regulation of interleukin-6 production. Function: cytokine activity, protein binding. Component: extracellular region, extracellular space. Beta: 0.99. | cg07387931 (chr3:141066318, +, CpG Island). In SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4) body (exon_2), 16kbp downstream of TSS. Process: proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of protein polyubiquitination, intracellular signal transduction, regulation of circadian rhythm. Function: protein binding, ubiquitin-like ligase-substrate adaptor activity. Component: SCF ubiquitin ligase complex, cytoplasm, cytosol. Beta: 0.99. | cg07550554 (chr14:72929070, -, S_Shelf 2162bp). In DCAF4 (DDB1 and CUL4 associated factor 4) body (intron_1), 3kbp downstream of TSS. Process: cell population proliferation, protein ubiquitination. Function: protein binding. Component: Cul4-RING E3 ubiquitin ligase complex, nucleoplasm. Beta: 0.99. | cg07591937 (chr1:248848306, +, CpG Island). In ZNF672 (zinc finger protein 672) body (exon_4), 10kbp downstream of TSS. Process: regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific DNA binding, metal ion binding, protein binding. Component: nucleoplasm, nucleus. Beta: 0.99. | cg09207578 (chr13:114016473, -, CpG Island). In RASA3 (RAS p21 protein activator 3) body (intron_12), 116kbp downstream of TSS. Process: negative regulation of Ras protein signal transduction, platelet activation, response to stress, regulation of intracellular signal transduction. Function: GTPase activator activity, calcium channel regulator activity, metal ion binding, zinc ion binding. Component: cytoplasmic side of plasma membrane, cytosol, plasma membrane. Beta: 0.99. | cg12266049 (chr11:69646566, +, CpG Island). In CCND1 (cyclin D1) body (intron_3), 5kbp downstream of TSS. Process: positive regulation of G1/S transition of mitotic cell cycle, negative regulation of transcription by RNA polymerase II, mitotic G1 DNA damage checkpoint signaling, response to xenobiotic stimulus. Function: cyclin-dependent protein serine/threonine kinase activator activity, protein-containing complex binding, transcription corepressor activity, histone deacetylase binding. Component: cyclin-dependent protein kinase holoenzyme complex, transcription repressor complex, microtubule organizing center, bicellular tight junction. Beta: 0.99. | cg13914990 (chr12:120737075, +, N_Shelf 2238bp). In ACADS (acyl-CoA dehydrogenase short chain) body (exon_3), 11kbp downstream of TSS; ENSG00000255946 body (intron_1), 25kbp downstream of TSS. Process: fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid metabolic process, butyrate catabolic process, fatty acid beta-oxidation. Function: oxidoreductase activity, acting on the CH-CH group of donors, short-chain fatty acyl-CoA dehydrogenase activity, flavin adenine dinucleotide binding, oxidoreductase activity. Component: mitochondrial matrix, mitochondrion, nucleus. Beta: 0.99. | cg15142488 (chr19:41844884, -, CpG Island). In DMRTC2 (DMRT like family C2) body, 141bp downstream of TSS; LYPD4 (LY6/PLAUR domain containing 4) promoter, 187bp upstream of TSS. Process: cell differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, sex differentiation. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific double-stranded DNA binding, identical protein binding, metal ion binding. Component: XY body, chromatin, nucleus. Component: extracellular region, plasma membrane raft, acrosomal vesicle, side of membrane. Beta: 0.99. | cg15156844 (chr18:3880020, -, CpG Island). In DLGAP1 (DLG associated protein 1) body (exon_4), 575kbp downstream of TSS; DLGAP1-AS3 body (intron_1), 2kbp downstream of TSS. Process: chemical synaptic transmission, modulation of chemical synaptic transmission, signaling. Function: molecular adaptor activity, protein binding, protein-containing complex binding. Component: postsynaptic specialization, glutamatergic synapse, postsynaptic density, plasma membrane. Beta: 0.99. | cg16142349 (chr6:166497521, -, OpenSea). In RPS6KA2 (ribosomal protein S6 kinase A2) body (intron_8), 409kbp downstream of TSS. Process: negative regulation of cell population proliferation, positive regulation of apoptotic process, intracellular signal transduction, chemical synaptic transmission. Function: protein serine/threonine/tyrosine kinase activity, magnesium ion binding, transferase activity, nucleotide binding. Component: meiotic spindle, nucleoplasm, cytoplasm, cytosol. Beta: 0.99. | cg16369288 (chr3:44579234, +, CpG Island). In ZNF660 (zinc finger protein 660) body, 1kbp downstream of TSS; ZKSCAN7 (zinc finger with KRAB and SCAN domains 7) body, 24kbp downstream of TSS. Process: regulation of transcription by RNA polymerase II. Function: RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, metal ion binding, protein binding. Component: nucleus. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Component: cytosol, nucleus. Beta: 0.99. | cg17016890 (chr18:48029801, -, CpG Island). In ZBTB7C (zinc finger and BTB domain containing 7C) body (exon_5), 381kbp downstream of TSS. Process: negative regulation of cell population proliferation, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding. Component: nucleus. Beta: 0.99. | cg19199752 (chr21:44310353, -, CpG Island). In PFKL (phosphofructokinase, liver type) body (intron_2), 10kbp downstream of TSS. Process: fructose 1,6-bisphosphate metabolic process, canonical glycolysis, response to glucose, glycolytic process. Function: 6-phosphofructokinase activity, fructose-6-phosphate binding, identical protein binding, monosaccharide binding. Component: 6-phosphofructokinase complex, ficolin-1-rich granule lumen, extracellular exosome, extracellular region. Beta: 0.99. | cg19306958 (chr22:46386446, -, N_Shelf 2829bp). In CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1) body (exon_19), 151kbp downstream of TSS. Process: orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis, protein localization involved in establishment of planar polarity, Wnt signaling pathway, planar cell polarity pathway, establishment of body hair planar orientation. Function: G protein-coupled receptor activity, calcium ion binding, transmembrane signaling receptor activity. Component: adherens junction, membrane, plasma membrane. Beta: 0.99. | cg19721055 (chr19:12642515, +, CpG Island). Intergenic. Beta: 0.99. | cg20679271 (chr2:127592867, -, CpG Island). In MYO7B (myosin VIIB) body (exon_17), 57kbp downstream of TSS. Process: actin filament-based movement, actin filament organization, sensory perception of sound, sensory organ development. Function: microfilament motor activity, actin filament binding, nucleotide binding, protein binding. Component: stereocilia ankle link, actin cytoskeleton, apical cytoplasm, myosin complex. Beta: 0.99. | cg21010435 (chr7:157416188, +, CpG Island). In DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6) body (exon_10), 81kbp downstream of TSS. Process: negative regulation of inclusion body assembly, regulation of cellular response to heat, intermediate filament organization, regulation of protein localization. Function: protein-folding chaperone binding, heat shock protein binding, ATPase activator activity, protein folding chaperone. Component: perinuclear region of cytoplasm, nucleoplasm, membrane, cytosol. Beta: 0.99. | cg21564965 (chr17:38469939, -, OpenSea). In ARHGAP23 (Rho GTPase activating protein 23) body (intron_10), 51kbp downstream of TSS; ENSG00000276170 body, 159bp downstream of TSS. Process: regulation of small GTPase mediated signal transduction, signal transduction. Function: GTPase activator activity. Component: cytosol, extracellular exosome. Beta: 0.99. | cg21566513 (chr13:24338946, -, N_Shore 1465bp). In ENSG00000304432 body (intron_1), 299bp downstream of TSS. Beta: 0.99. | cg22857025 (chr5:266819, +, OpenSea). In ENSG00000286001 body (intron_16), 49kbp downstream of TSS. Beta: 0.99. | cg22896075 (chr17:40362161, +, N_Shore 553bp). In GJD3 (gap junction protein delta 3) body (exon_1), 3kbp downstream of TSS; GJD3-AS1 body (intron_1), 2kbp downstream of TSS. Process: AV node cell to bundle of His cell communication by electrical coupling, negative regulation of cardiac conduction, monoatomic ion transmembrane transport, gap junction assembly. Function: gap junction channel activity, gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling, monoatomic ion channel activity, protein binding. Component: cell surface, connexin complex, gap junction, plasma membrane. Beta: 0.99. | cg23023126 (chr19:308808, -, CpG Island). In MIER2 (MIER family member 2) body (exon_11), 36kbp downstream of TSS. Process: chromatin remodeling, negative regulation of transcription by RNA polymerase II. Function: histone deacetylase activity, histone deacetylase binding, protein binding, transcription corepressor activity. Component: cytoplasm, nucleoplasm, nucleus, protein-containing complex. Beta: 0.99. | cg25732961 (chr17:7852559, +, S_Shore 293bp). In KDM6B (lysine demethylase 6B) body (exon_21), 18kbp downstream of TSS. Process: positive regulation of transcription by RNA polymerase II, inflammatory response to antigenic stimulus, cardiac muscle cell differentiation, regulation of gene expression. Function: RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone H3K27me2/H3K27me3 demethylase activity, oxidoreductase activity, beta-catenin binding. Component: MLL3/4 complex, nucleoplasm, nucleus. Beta: 0.99. | cg26301689 (chr3:142962862, -, CpG Island). In PAQR9 (progestin and adipoQ receptor family member 9) body (exon_1), 1kbp downstream of TSS; PAQR9-AS1 body, 2kbp downstream of TSS. Function: lipid binding, signaling receptor activity, steroid binding. Component: membrane, plasma membrane. Beta: 0.99. | cg27437510 (chr7:151120110, +, CpG Island). In AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3) body (exon_8), 34kbp downstream of TSS. Process: cellular response to reactive oxygen species, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of postsynaptic membrane neurotransmitter receptor levels. Function: polyubiquitin modification-dependent protein binding, GTPase activator activity, nucleotide binding, metal ion binding. Component: glutamatergic synapse, postsynaptic density, cell periphery, cytoplasm. Beta: 0.99. | cg00077898 (chr6:1080909, +, OpenSea). In ENSG00000176515 body (intron_1), 980bp downstream of TSS; LINC01622 body (intron_1), 21kbp downstream of TSS. Beta: 0.98. | cg00373376 (chr7:2091034, -, OpenSea). In MAD1L1 (mitotic arrest deficient 1 like 1) body (intron_11), 142kbp downstream of TSS; ENSG00000286192 body (intron_16), 151kbp downstream of TSS. Process: positive regulation of mitotic cell cycle spindle assembly checkpoint, attachment of mitotic spindle microtubules to kinetochore, regulation of metaphase plate congression, cell division. Function: kinetochore binding, protein binding. Component: mitotic spindle assembly checkpoint MAD1-MAD2 complex, nuclear pore nuclear basket, nuclear envelope, nuclear membrane. Beta: 0.98. | cg00678709 (chr3:14543238, +, OpenSea). In GRIP2 (glutamate receptor interacting protein 2) body, 13kbp downstream of TSS. Process: neurotransmitter receptor transport, endosome to postsynaptic membrane. Function: protein binding. Component: glutamatergic synapse, plasma membrane, cytoplasm, cytosol. Beta: 0.98. | cg00910503 (chr17:82435790, -, CpG Island). In HEXD (hexosaminidase D) body (exon_6), 17kbp downstream of TSS. Process: carbohydrate metabolic process. Function: hydrolase activity, hydrolyzing O-glycosyl compounds, hydrolase activity, acting on glycosyl bonds, beta-N-acetylhexosaminidase activity, hexosaminidase activity. Component: cytoplasm, extracellular vesicle, nucleus. Beta: 0.98. | cg01305596 (chr16:16134442, +, OpenSea). In ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group)) body (exon_28), 185kbp downstream of TSS. Process: xenobiotic transport across blood-brain barrier, positive regulation of inflammatory response, carboxylic acid transmembrane transport, cellular response to oxidative stress. Function: ATPase-coupled lipid transmembrane transporter activity, ABC-type glutathione S-conjugate transporter activity, ATP hydrolysis activity, hydrolase activity. Component: basolateral plasma membrane, extracellular exosome, cell junction, lateral plasma membrane. Beta: 0.98. | cg02071579 (chr16:88484042, -, N_Shelf 3905bp). In ZFPM1 (zinc finger protein, FOG family member 1) body (intron_1), 31kbp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, positive regulation of macromolecule biosynthetic process, anatomical structure formation involved in morphogenesis, negative regulation of multicellular organismal process. Function: RNA polymerase II-specific DNA-binding transcription factor binding, transcription corepressor activity, metal ion binding, protein binding. Component: transcription regulator complex, nucleoplasm, chromatin, nucleus. Beta: 0.98. | cg02249577 (chr10:50675018, -, CpG Island). In ENSG00000303532 body, 2kbp downstream of TSS; SGMS1-AS1 body (intron_2), 52kbp downstream of TSS. Beta: 0.98. | cg02371401 (chr5:676669, -, N_Shore 1030bp). In TPPP (tubulin polymerization promoting protein) body (intron_2), 17kbp downstream of TSS. Process: positive regulation of protein-containing complex assembly, microtubule nucleation by microtubule organizing center, regulation of microtubule cytoskeleton organization, negative regulation of tubulin deacetylation. Function: protein homodimerization activity, magnesium ion binding, microtubule binding, hydrolase activity. Component: perinuclear region of cytoplasm, microtubule organizing center, postsynaptic Golgi apparatus, microtubule bundle. Beta: 0.98. | cg02515033 (chr7:2165648, +, OpenSea). In MAD1L1 body (intron_10), 68kbp downstream of TSS; ENSG00000286192 body (intron_15), 77kbp downstream of TSS. Beta: 0.98. | cg02723533 (chr11:69654223, -, CpG Island). In CCND1 body (exon_5), 13kbp downstream of TSS; LTO1 (LTO1 maturation factor of ABCE1) body, 21kbp downstream of TSS. Process: protein maturation, ribosomal large subunit biogenesis, telomere maintenance, translational initiation. Function: protein binding. Component: nucleus. Beta: 0.98. | cg03136712 (chr5:140673483, +, CpG Island). In DND1 (DND microRNA-mediated repression inhibitor 1) body (intron_1), 93bp downstream of TSS; WDR55 (WD repeat domain 55) body, 9kbp downstream of TSS. Process: negative regulation of miRNA-mediated gene silencing, 3'-UTR-mediated mRNA destabilization, germ cell development, mRNA stabilization. Function: nucleic acid binding, mRNA 3'-UTR binding, protein binding, RNA binding. Component: cytoplasm, cytosol, nucleoplasm, nucleus. Process: rRNA processing. Component: cytoplasm, nucleolus, nucleoplasm. Beta: 0.98. | cg03633073 (chr16:89371110, -, OpenSea). In ENSG00000288715 body (intron_1), 47kbp downstream of TSS; ANKRD11 (ankyrin repeat domain 11) body (intron_2), 119kbp downstream of TSS. Process: odontogenesis of dentin-containing tooth, skeletal system morphogenesis, face morphogenesis, head morphogenesis. Component: cytosol, nucleoplasm, nucleus. Beta: 0.98. | cg03729251 (chr4:150579883, +, CpG Island). In LRBA (LPS responsive beige-like anchor protein) body (intron_40), 436kbp downstream of TSS; LRBA-AS1 body (exon_2), 794bp downstream of TSS. Process: mitophagy, protein localization to phagophore assembly site. Function: protein binding, protein kinase binding. Component: endoplasmic reticulum membrane, lysosomal membrane, Golgi apparatus, plasma membrane. Beta: 0.98. | cg03760035 (chr21:31251990, +, CpG Island). In TIAM1 (TIAM Rac1 associated GEF 1) body (exon_5), 308kbp downstream of TSS. Process: positive regulation of epithelial to mesenchymal transition, regulation of small GTPase mediated signal transduction, positive regulation of cell population proliferation, Wnt signaling pathway, planar cell polarity pathway. Function: guanyl-nucleotide exchange factor activity, kinase binding, lipid binding, protein binding. Component: cell-cell contact zone, anchoring junction, cell-cell junction, plasma membrane. Beta: 0.98. | cg03991547 (chr13:112160805, -, N_Shelf 2698bp). In ENSG00000304701 promoter, 908bp upstream of TSS; ENSG00000304677 body (intron_1), 3kbp downstream of TSS. Beta: 0.98. | cg04027043 (chr11:8357244, +, OpenSea). Intergenic. Beta: 0.98. | cg04254198 (chr17:79706040, +, OpenSea). In LINC02078 promoter, 1kbp upstream of TSS; ENSG00000306583 body (intron_1), 27kbp downstream of TSS. Beta: 0.98. | cg04411052 (chr14:71752344, -, OpenSea). In ENSG00000302484 promoter, 461bp upstream of TSS. Beta: 0.98. | cg04511195 (chr19:3523011, +, OpenSea). In FZR1 (fizzy and cell division cycle 20 related 1) body (exon_2), 17kbp downstream of TSS. Process: positive regulation of anaphase-promoting complex-dependent catabolic process, positive regulation of ubiquitin protein ligase activity, positive regulation of cell population proliferation, mitotic G2 DNA damage checkpoint signaling. Function: ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activator activity, ubiquitin ligase activator activity, anaphase-promoting complex binding. Component: anaphase-promoting complex, nuclear membrane, nucleoplasm, cytoplasm. Beta: 0.98. | cg04904318 (chr17:48530466, -, CpG Island). In HOXB1 (homeobox B1) body (exon_1), 545bp downstream of TSS; ENSG00000294508 body (intron_2), 3kbp downstream of TSS. Process: pattern specification process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, protein domain specific binding. Component: chromatin, nucleoplasm, nucleus. Beta: 0.98. | cg04927341 (chr1:86110814, +, OpenSea). In COL24A1 (collagen type XXIV alpha 1 chain) body (intron_5), 46kbp downstream of TSS. Process: extracellular matrix organization. Function: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, protein binding. Component: basement membrane, endoplasmic reticulum lumen, extracellular matrix, extracellular region. Beta: 0.98. | cg05218653 (chr16:2284963, -, S_Shore 617bp). In ABCA3 body (exon_24), 56kbp downstream of TSS. Beta: 0.98. | cg05804170 (chr1:3204950, +, OpenSea). In PRDM16 (PR/SET domain 16) body (intron_2), 136kbp downstream of TSS; ENSG00000279839 promoter, 1kbp upstream of TSS. Process: negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of white fat cell differentiation, tolerance induction in gut-associated lymphoid tissue. Function: DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone H3K9 monomethyltransferase activity, DNA-binding transcription factor activity. Component: transcription repressor complex, nuclear body, nucleoplasm, chromosome. Beta: 0.98. | cg05928290 (chr14:53952010, -, CpG Island). In BMP4 (bone morphogenetic protein 4) body (exon_3), 7kbp downstream of TSS. Process: positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis, negative regulation of mesenchymal cell proliferation involved in ureter development, blood vessel endothelial cell proliferation involved in sprouting angiogenesis, negative regulation of vascular associated smooth muscle cell migration. Function: chemoattractant activity, growth factor activity, BMP receptor binding, co-receptor binding. Component: endoplasmic reticulum lumen, extracellular region, extracellular space. Beta: 0.98. | cg05982473 (chr11:3166573, -, S_Shore 1035bp). In OSBPL5 (oxysterol binding protein like 5) body, 166bp downstream of TSS. Process: phosphatidylserine acyl-chain remodeling, intermembrane phospholipid transfer, Golgi to plasma membrane transport, cholesterol metabolic process. Function: phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity, phosphatidylinositol-4-phosphate binding, phosphatidylserine transfer activity, phospholipid transporter activity. Component: endoplasmic reticulum-plasma membrane contact site, transporter complex, cytosol, endoplasmic reticulum membrane. Beta: 0.98. | cg06127256 (chr16:73172689, +, OpenSea). In ZFHX3 (zinc finger homeobox 3) body, 719kbp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, positive regulation of myoblast differentiation, response to transforming growth factor beta, circadian regulation of gene expression. Function: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, nucleic acid binding. Component: transcription regulator complex, nuclear body, nucleoplasm, chromatin. Beta: 0.98. | cg06236737 (chr16:89883811, +, S_Shelf 3896bp). In TCF25 (TCF25 ribosome quality control complex subunit) body (intron_2), 10kbp downstream of TSS. Process: regulation of protein K48-linked ubiquitination, rescue of stalled cytosolic ribosome, ribosome-associated ubiquitin-dependent protein catabolic process. Function: protein binding. Component: RQC complex, cytosol, nucleus. Beta: 0.98. | cg06554744 (chr17:18247821, -, CpG Island). In FLII (FLII actin remodeling protein) body (exon_20), 11kbp downstream of TSS. Process: actin polymerization or depolymerization, barbed-end actin filament capping, sarcomere organization, myofibril assembly. Function: actin binding, actin filament binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding. Component: actin cytoskeleton, focal adhesion, brush border, centrosome. Beta: 0.98. | cg06565975 (chr8:142742499, -, S_Shelf 2607bp). In SLURP1 (secreted LY6/PLAUR domain containing 1) promoter, 93bp upstream of TSS; ENSG00000253196 body (intron_1), 4kbp downstream of TSS. Process: negative regulation of cell population proliferation, urokinase plasminogen activator signaling pathway, cell activation, cell adhesion. Function: acetylcholine receptor activator activity, cytokine activity, protein binding. Component: extracellular exosome, extracellular region, extracellular space. Beta: 0.98. | cg06566039 (chr6:22569556, +, CpG Island). In HDGFL1 (HDGF like 1) promoter, 10bp upstream of TSS; CASC15 body, 905kbp downstream of TSS. Process: chromatin remodeling. Component: nucleus. Beta: 0.98. | cg06807993 (chr17:81125985, -, N_Shelf 2964bp). In AATK (apoptosis associated tyrosine kinase) body (intron_7), 40kbp downstream of TSS; MIR338 promoter, 36bp upstream of TSS. Process: brain development, neuron apoptotic process. Function: protein serine/threonine kinase activity, transferase activity, nucleotide binding, protein binding. Component: cytoplasm, endomembrane system, membrane, perinuclear region of cytoplasm. Beta: 0.98. | cg06933816 (chr16:70664243, -, CpG Island). In MTSS2 (MTSS I-BAR domain containing 2) body (exon_15), 22kbp downstream of TSS; ENSG00000279569 body, 3kbp downstream of TSS. Process: cellular response to platelet-derived growth factor stimulus, activation of GTPase activity, plasma membrane organization, cell projection assembly. Function: phosphatidylinositol-4,5-bisphosphate binding, GTPase activator activity, actin monomer binding, phospholipid binding. Component: cortical actin cytoskeleton, plasma membrane, ruffle membrane, focal adhesion. Beta: 0.98. | cg07690734 (chr10:132375157, -, OpenSea). In LRRC27 (leucine rich repeat containing 27) body (exon_11), 43kbp downstream of TSS. Function: protein binding. Beta: 0.98. | cg08076462 (chr16:87750704, +, OpenSea). In KLHDC4 (kelch domain containing 4) body (intron_4), 15kbp downstream of TSS. Function: protein binding. Beta: 0.98. | cg08389497 (chr10:72060733, +, OpenSea). In SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2) body (exon_11), 28kbp downstream of TSS. Process: regulation of cell-substrate adhesion, positive regulation of cell motility, extracellular matrix organization, synapse assembly. Function: metalloendopeptidase inhibitor activity, extracellular matrix binding, glycosaminoglycan binding, calcium ion binding. Component: extracellular matrix, extracellular space, gel phase of interstitial matrix. Beta: 0.98. | cg08786136 (chr16:88992207, -, OpenSea). In ENSG00000259989 body (exon_2), 29kbp downstream of TSS. Beta: 0.98. | cg08971334 (chr5:769980, +, OpenSea). In ZDHHC11B (zDHHC palmitoyltransferase 11B (putative)) body (intron_1), 15kbp downstream of TSS; BRD9P2 promoter, 1kbp upstream of TSS. Process: antiviral innate immune response, protein targeting to membrane. Function: acyltransferase activity, palmitoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, transferase activity. Component: Golgi apparatus, endoplasmic reticulum, membrane. Beta: 0.98. | cg09053902 (chr16:3984297, -, OpenSea). In ADCY9 (adenylate cyclase 9) body (intron_6), 132kbp downstream of TSS. Process: adenylate cyclase-activating G protein-coupled receptor signaling pathway, vascular endothelial cell response to laminar fluid shear stress, cellular response to glucagon stimulus, cyclic nucleotide biosynthetic process. Function: phosphorus-oxygen lyase activity, adenylate cyclase activity, nucleotide binding, metal ion binding. Component: axon, dendrite, membrane, plasma membrane. Beta: 0.98. | cg09115646 (chr10:2936495, -, OpenSea). In ENSG00000295558 promoter, 1kbp upstream of TSS. Beta: 0.98. | cg09178970 (chr12:122867251, +, CpG Island). In VPS37B (VPS37B subunit of ESCRT-I) body (exon_4), 29kbp downstream of TSS. Process: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, positive regulation of viral budding via host ESCRT complex, protein targeting to membrane, viral release from host cell. Function: calcium-dependent protein binding, protein binding. Component: late endosome membrane, extracellular exosome, ESCRT I complex, plasma membrane. Beta: 0.98. | cg09655876 (chr6:161140034, -, OpenSea). In AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4) body (intron_7), 134kbp downstream of TSS. Process: CDP-diacylglycerol biosynthetic process, phospholipid metabolic process, phosphatidic acid biosynthetic process, phospholipid biosynthetic process. Function: 1-acylglycerol-3-phosphate O-acyltransferase activity, lysophosphatidic acid acyltransferase activity, transferase activity, protein binding. Component: endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, mitochondrial outer membrane. Beta: 0.98. | cg09848445 (chr10:43106414, -, S_Shore 697bp). In RET (ret proto-oncogene) body (exon_5), 29kbp downstream of TSS. Process: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, glial cell-derived neurotrophic factor receptor signaling pathway, cell surface receptor protein tyrosine kinase signaling pathway. Function: transmembrane receptor protein tyrosine kinase activity, transferase activity, calcium ion binding, nucleotide binding. Component: plasma membrane protein complex, endosome membrane, receptor complex, axon. Beta: 0.98. | cg09888620 (chr22:39649699, -, CpG Island). In CACNA1I (calcium voltage-gated channel subunit alpha1 I) body (exon_10), 79kbp downstream of TSS. Process: calcium ion import across plasma membrane, monoatomic ion transmembrane transport, signal transduction, calcium ion transmembrane transport. Function: high voltage-gated calcium channel activity, monoatomic ion channel activity, protein binding, voltage-gated calcium channel activity. Component: membrane, monoatomic ion channel complex, plasma membrane, voltage-gated calcium channel complex. Beta: 0.98. | cg09974041 (chr8:10416380, +, OpenSea). In MSRA (methionine sulfoxide reductase A) body (intron_5), 362kbp downstream of TSS. Process: cellular response to oxidative stress, methionine metabolic process, protein modification process, protein repair. Function: L-methionine (S)-S-oxide reductase activity, oxidoreductase activity, peptide-methionine (S)-S-oxide reductase activity, protein binding. Component: extracellular exosome, mitochondrial matrix, mitochondrion, nucleoplasm. Beta: 0.98. | cg10107671 (chr19:647289, -, CpG Island). Intergenic. Beta: 0.98. | cg10150962 (chr16:86370773, -, OpenSea). Intergenic. Beta: 0.98. | cg10316525 (chr15:40279936, +, CpG Island). In ANKRD63 (ankyrin repeat domain 63) body (exon_1), 3kbp downstream of TSS; PLCB2 (phospholipase C beta 2) body, 28kbp downstream of TSS. Process: detection of chemical stimulus involved in sensory perception of bitter taste, phospholipase C-activating G protein-coupled receptor signaling pathway, release of sequestered calcium ion into cytosol, phosphatidylinositol-mediated signaling. Function: phosphatidylinositol-4,5-bisphosphate phospholipase C activity, G-protein beta/gamma-subunit complex binding, phosphoric diester hydrolase activity, C-type glycerophospholipase activity. Component: G-protein beta/gamma-subunit complex, cytoplasm, cytosol, neuronal dense core vesicle. Beta: 0.98. | cg11120115 (chr7:99052238, -, OpenSea). In SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) body (exon_7), 92kbp downstream of TSS. Process: negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of ubiquitin-dependent protein catabolic process, Wnt signaling pathway, planar cell polarity pathway, protein targeting to vacuole involved in autophagy. Function: transforming growth factor beta receptor binding, ubiquitin-protein transferase activity, ubiquitin protein ligase activity, phospholipid binding. Component: extracellular exosome, neuronal cell body, plasma membrane, mitochondrion. Beta: 0.98. | cg11218175 (chr11:495084, -, CpG Island). In RNH1 (ribonuclease/angiogenin inhibitor 1) body (intron_9), 12kbp downstream of TSS. Process: regulation of Arp2/3 complex-mediated actin nucleation, mRNA catabolic process, tRNA stabilization, cell migration. Function: protein binding, ribonuclease inhibitor activity. Component: angiogenin-PRI complex, extracellular exosome, plasma membrane, lamellipodium. Beta: 0.98. | cg11408395 (chr15:101045506, -, OpenSea). In LRRK1 (leucine rich repeat kinase 1) body (intron_20), 126kbp downstream of TSS; LRRK1-AS1 body, 41kbp downstream of TSS. Process: positive regulation of canonical Wnt signaling pathway, positive regulation of signal transduction. Function: protein serine/threonine kinase activity, identical protein binding, transferase activity, nucleotide binding. Component: cytoplasm, cytosol, plasma membrane. Beta: 0.98. | cg11410726 (chr11:69810641, +, CpG Island). In FGF3 (fibroblast growth factor 3) body (exon_3), 9kbp downstream of TSS. Process: negative regulation of cardiac muscle tissue development, positive regulation of cell population proliferation, fibroblast growth factor receptor signaling pathway, regulation of multicellular organismal process. Function: fibroblast growth factor receptor binding, growth factor activity, protein binding. Component: cytoplasm, extracellular region, extracellular space. Beta: 0.98. | cg11449408 (chr17:82898181, -, N_Shore 818bp). In TBCD (tubulin folding cofactor D) body (intron_17), 146kbp downstream of TSS. Process: cell morphogenesis involved in neuron differentiation, negative regulation of microtubule polymerization, post-chaperonin tubulin folding pathway, microtubule cytoskeleton organization. Function: GTPase activator activity, beta-tubulin binding, protein binding, protein-folding chaperone binding. Component: bicellular tight junction, lateral plasma membrane, adherens junction, microtubule. Beta: 0.98. | cg11617144 (chr8:144504389, -, N_Shore 619bp). In GPT (glutamic--pyruvic transaminase) body (exon_1), 2kbp downstream of TSS; ENSG00000255182 body (intron_2), 1kbp downstream of TSS. Process: L-alanine catabolic process. Function: L-alanine:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding, transaminase activity, transferase activity. Component: cytoplasm, cytosol, extracellular exosome, extracellular space. Beta: 0.98. | cg11710211 (chr19:56097695, -, CpG Island). In ZNF787 (zinc finger protein 787) body (intron_2), 24kbp downstream of TSS. Process: regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific double-stranded DNA binding, metal ion binding, sequence-specific DNA binding. Component: nucleus. Beta: 0.98. | cg11908202 (chr17:43378979, -, CpG Island). In LINC00910 body (intron_3), 10kbp downstream of TSS. Beta: 0.98. | cg12205822 (chr12:2504775, -, OpenSea). In CACNA1C body (intron_7), 534kbp downstream of TSS. Beta: 0.98. | cg12216054 (chr6:33456436, +, S_Shore 1683bp). In ZBTB9 (zinc finger and BTB domain containing 9) body (exon_2), 2kbp downstream of TSS. Process: regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding. Component: nucleus. Beta: 0.98. | cg12888113 (chr1:11046991, -, OpenSea). In MASP2 (MBL associated serine protease 2) body (exon_2), 250bp downstream of TSS. Process: cell surface pattern recognition receptor signaling pathway, complement activation, classical pathway, positive regulation of opsonization, innate immune response. Function: serine-type endopeptidase activity, calcium-dependent protein binding, complement component C4b binding, calcium ion binding. Component: external side of plasma membrane, extracellular exosome, symbiont cell surface, extracellular region. Beta: 0.98. | cg13008301 (chr20:56403693, +, CpG Island). In CSTF1 (cleavage stimulation factor subunit 1) body (exon_6), 11kbp downstream of TSS. Process: mRNA 3'-end processing, mRNA processing, regulation of mRNA 3'-end processing. Function: RNA binding, protein binding. Component: mRNA cleavage stimulating factor complex, nucleoplasm, nucleus. Beta: 0.98. | cg13244241 (chr10:100731974, -, S_Shore 720bp). In ENSG00000295664 promoter, 636bp upstream of TSS; ENSG00000295641 body (exon_3), 3kbp downstream of TSS. Beta: 0.98. | cg13244315 (chr1:1050013, -, S_Shore 964bp). In AGRN (agrin) body (exon_27), 30kbp downstream of TSS. Process: positive regulation of synaptic assembly at neuromuscular junction, G protein-coupled acetylcholine receptor signaling pathway, positive regulation of transcription by RNA polymerase II, clustering of voltage-gated sodium channels. Function: transmembrane receptor protein tyrosine kinase activator activity, extracellular matrix structural constituent, acetylcholine receptor regulator activity, structural constituent of cytoskeleton. Component: gel phase of basement membrane, extracellular exosome, extracellular matrix, extracellular region. Beta: 0.98. | cg13476777 (chr9:137017232, +, CpG Island). In ABCA2 (ATP binding cassette subfamily A member 2) body (exon_18), 12kbp downstream of TSS. Process: negative regulation of receptor-mediated endocytosis involved in cholesterol transport, positive regulation of low-density lipoprotein particle receptor catabolic process, positive regulation of amyloid precursor protein biosynthetic process, regulation of protein localization to cell periphery. Function: ATPase-coupled transmembrane transporter activity, endopeptidase regulator activity, ceramide floppase activity, ATP hydrolysis activity. Component: ATP-binding cassette (ABC) transporter complex, intracellular membrane-bounded organelle, microtubule organizing center, cytoplasmic vesicle. Beta: 0.98. | cg13909661 (chr12:26233900, -, OpenSea). In SSPN (sarcospan) body (exon_3), 112kbp downstream of TSS; ENSG00000255750 body (intron_1), 86kbp downstream of TSS. Process: camera-type eye development, cell adhesion, muscle contraction. Component: dystrophin-associated glycoprotein complex, neuromuscular junction, postsynaptic membrane, transport vesicle. Beta: 0.98. | cg14242024 (chr9:136075002, +, CpG Island). In NACC2 (NACC family member 2) body (intron_1), 20kbp downstream of TSS. Process: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of transcription by RNA polymerase II, negative regulation of cell population proliferation, protein-containing complex localization. Function: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein-containing complex binding, protein homodimerization activity. Component: chromatin, nuclear lumen, nucleus. Beta: 0.98. | cg14285937 (chr1:8338675, +, S_Shelf 3100bp). In SLC45A1 (solute carrier family 45 member 1) body (intron_7), 21kbp downstream of TSS. Process: D-glucose transmembrane transport, galactose transmembrane transport, sucrose transport, transmembrane transport. Function: D-glucose:proton symporter activity, transmembrane transporter activity, galactose:proton symporter activity, sucrose:proton symporter activity. Component: membrane. Beta: 0.98. | cg14435720 (chr9:136670635, +, CpG Island). In EGFL7 (EGF like domain multiple 7) body (intron_8), 12kbp downstream of TSS; MIR126 body (exon_1), 33bp downstream of TSS. Process: positive regulation of endothelial cell proliferation, negative regulation of Notch signaling pathway, blood vessel development, cell differentiation. Function: calcium ion binding, protein binding, signaling receptor binding. Component: cell surface, extracellular matrix, extracellular region. Beta: 0.98.\n\nOptions: A. 40-49 B. 30-39 C. 100+ D. 70-79 E. 80-89 F. 10-19 G. 50-59 H. 90-99 I. 0-9 J. 60-69 K. 20-29", | |
| "answer": "B", | |
| "ground_truth_note": "True age: 31 years, age group 30-39 (GSM1506465_GSE61496, GSE61496)." | |
| }, | |
| { | |
| "pool": "geodnam_age_regression", | |
| "display_name": "GEO DNAm Age / Regression", | |
| "domain": "epigenomics", | |
| "lb_code": "LB-0010", | |
| "prompt": "Based on the following DNA methylation profile from a blood sample, estimate the exact age (in years) of this individual.\n\nThe donor is A female, from Denmark.\n\nMethylation profile:\nLowest methylated (100 sites): cg00025138 (chr14:70809200, -, CpG Island). In MAP3K9 (mitogen-activated protein kinase kinase kinase 9) body (exon_1), 345bp downstream of TSS; MAP3K9-DT body, 389bp downstream of TSS. Process: positive regulation of apoptotic process, protein autophosphorylation, protein phosphorylation, signal transduction. Function: protein serine/threonine kinase activity, molecular function activator activity, transferase activity, nucleotide binding. Component: cytoplasm. Beta: 0.01. | cg00497554 (chr2:241315743, -, CpG Island). In SEPTIN2 (septin 2) body, 820bp downstream of TSS; HDLBP (high density lipoprotein binding protein) body, 1kbp downstream of TSS. Process: cytoskeleton-dependent cytokinesis, intracellular protein localization, smoothened signaling pathway, cytoskeleton organization. Function: molecular adaptor activity, enzyme regulator activity, identical protein binding, nucleotide binding. Component: photoreceptor connecting cilium, microtubule cytoskeleton, ciliary transition zone, extracellular exosome. Process: cholesterol metabolic process, lipid metabolic process, lipid transport, steroid metabolic process. Function: nucleic acid binding, cadherin binding, protein binding, lipid binding. Component: high-density lipoprotein particle, endoplasmic reticulum, plasma membrane, nuclear body. Beta: 0.01. | cg00702638 (chr3:44761801, -, CpG Island). In KIF15 (kinesin family member 15) body (exon_1), 80bp downstream of TSS; KIAA1143 (KIAA1143) body, 232bp downstream of TSS. Process: centrosome separation, microtubule-based movement, mitotic cell cycle, mitotic spindle assembly. Function: plus-end-directed microtubule motor activity, ATP hydrolysis activity, microtubule binding, nucleotide binding. Component: plus-end kinesin complex, spindle pole, microtubule, centrosome. Function: protein binding. Component: intercellular bridge, nucleoplasm. Beta: 0.01. | cg02047577 (chr20:63956349, -, CpG Island). In UCKL1 (uridine-cytidine kinase 1 like 1) body (exon_1), 131bp downstream of TSS; UCKL1-AS1 body (exon_1), 3kbp downstream of TSS. Process: nucleobase-containing small molecule metabolic process, nucleobase-containing compound biosynthetic process, carbohydrate derivative biosynthetic process, pyrimidine-containing compound salvage. Function: cytidine kinase activity, transferase activity, nucleotide binding, protein binding. Component: cytoplasm, cytosol, nucleus. Beta: 0.01. | cg02754722 (chr6:2765958, +, CpG Island). In WRNIP1 (WRN helicase interacting protein 1) body (exon_1), 565bp downstream of TSS; MYLK4 (myosin light chain kinase family member 4) body, 4kbp downstream of TSS. Process: regulation of DNA-templated DNA replication initiation, DNA synthesis involved in DNA repair, innate immune response, immune system process. Function: single-stranded DNA helicase activity, enzyme activator activity, identical protein binding, ATP hydrolysis activity. Component: perinuclear region of cytoplasm, chromosome, telomeric region, membrane, nucleus. Process: signal transduction. Function: protein serine/threonine kinase activity, myosin light chain kinase activity, transferase activity, nucleotide binding. Component: cytoplasm. Beta: 0.01. | cg02763101 (chr19:56393576, +, CpG Island). In ZNF582 (zinc finger protein 582) promoter, 38bp upstream of TSS; ZNF582-DT promoter, 80bp upstream of TSS. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, protein binding. Component: nucleus. Beta: 0.01. | cg03342084 (chr11:43880793, -, CpG Island). In ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase) promoter, 18bp upstream of TSS; ENSG00000246250 promoter, 67bp upstream of TSS. Process: negative regulation of cytoplasmic translation, cell population proliferation, DNA alkylation repair, DNA damage response. Function: broad specificity oxidative DNA demethylase activity, mRNA N1-methyladenosine dioxygenase activity, L-ascorbic acid binding, oxidoreductase activity. Component: cytoplasm, nucleoplasm, nucleus. Beta: 0.01. | cg03970588 (chr1:182391268, +, CpG Island). In GLUL (glutamate-ammonia ligase) body (intron_1), 938bp downstream of TSS; ENSG00000306613 promoter, 839bp upstream of TSS. Process: positive regulation of erythrocyte differentiation, regulation of protein localization to nucleolus, regulation of endothelial cell migration, regulation of sprouting angiogenesis. Function: protein-cysteine S-palmitoyltransferase activity, glutamine synthetase activity, identical protein binding, transferase activity. Component: extracellular exosome, glial cell projection, plasma membrane, mitochondrion. Beta: 0.01. | cg04301102 (chr5:132777449, -, CpG Island). In SEPTIN8 (septin 8) body, 30kbp downstream of TSS. Process: regulation of intracellular protein transport, regulation of SNARE complex assembly, cytoskeleton-dependent cytokinesis, intracellular protein localization. Function: molecular adaptor activity, nucleotide binding, GTPase activity, protein binding. Component: synaptic vesicle membrane, microtubule cytoskeleton, cytoplasmic vesicle, cell division site. Beta: 0.01. | cg04528217 (chr6:32154707, +, CpG Island). In ENSG00000285085 promoter, 334bp upstream of TSS; PPT2-EGFL8 (PPT2-EGFL8 readthrough (NMD candidate)) body (exon_2), 862bp downstream of TSS. Beta: 0.01. | cg04689080 (chr22:45867327, +, CpG Island). Intergenic. Beta: 0.01. | cg05369142 (chr3:46693519, -, CpG Island). In ALS2CL (ALS2 C-terminal like) body (intron_1), 552bp downstream of TSS; TMIE (transmembrane inner ear) promoter, 1kbp upstream of TSS. Process: endosomal transport. Function: GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding. Component: cytoplasm, cytoplasmic vesicle, cytosol. Process: inner ear morphogenesis, sensory perception of sound. Component: membrane. Beta: 0.01. | cg05875700 (chr8:688208, +, CpG Island). In ERICH1 (glutamate rich 1) body (intron_3), 50kbp downstream of TSS. Function: protein binding. Beta: 0.01. | cg05890887 (chr4:39458979, +, CpG Island). In LIAS (lipoic acid synthetase) promoter, 25bp upstream of TSS; RPL9 (ribosomal protein L9) promoter, 31bp upstream of TSS. Process: response to lipopolysaccharide, lipoate biosynthetic process, inflammatory response, protein lipoylation. Function: 4 iron, 4 sulfur cluster binding, sulfurtransferase activity, lipoate synthase activity, transferase activity. Component: mitochondrial matrix, mitochondrion. Process: negative regulation of myoblast fusion, striated muscle contraction, cytoplasmic translation, spermatogenesis. Function: RNA binding, protein binding, rRNA binding, structural constituent of ribosome. Component: cytosolic large ribosomal subunit, ribonucleoprotein complex, endoplasmic reticulum, cytosolic ribosome. Beta: 0.01. | cg06213463 (chr16:56589303, -, CpG Island). In MT3 (metallothionein 3) body, 229bp downstream of TSS. Process: positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of hydrogen peroxide catabolic process, negative regulation of neuron projection development, cellular response to reactive oxygen species. Function: protein kinase activator activity, antioxidant activity, cadmium ion binding, protein binding. Component: perinuclear region of cytoplasm, mitochondrial outer membrane, astrocyte projection, extracellular space. Beta: 0.01. | cg06799298 (chr17:4143054, +, CpG Island). In CYB5D2 (cytochrome b5 domain containing 2) promoter, 114bp upstream of TSS; ZZEF1 (zinc finger ZZ-type and EF-hand domain containing 1) body, 574bp downstream of TSS. Process: nervous system development. Function: heme binding, protein binding, steroid binding. Component: endomembrane system, extracellular region, membrane. Function: calcium ion binding, histone binding, protein binding, metal ion binding. Beta: 0.01. | cg07063853 (chr11:43311962, -, CpG Island). In API5 (apoptosis inhibitor 5) body, 7bp downstream of TSS. Process: apoptotic process, negative regulation of apoptotic process. Function: RNA binding, fibroblast growth factor binding, protein binding. Component: spliceosomal complex, nuclear speck, cytoplasm, membrane. Beta: 0.01. | cg07910813 (chr18:67516508, +, CpG Island). In DSEL (dermatan sulfate epimerase like) body (exon_1), 215bp downstream of TSS; DSEL-AS1 promoter, 38bp upstream of TSS. Process: chondroitin sulfate proteoglycan metabolic process, dermatan sulfate proteoglycan biosynthetic process, dermatan sulfate proteoglycan metabolic process. Function: chondroitin-glucuronate 5-epimerase activity, isomerase activity, sulfotransferase activity. Component: Golgi membrane, membrane. Beta: 0.01. | cg08475931 (chr7:30594777, -, CpG Island). In GARS1 (glycyl-tRNA synthetase 1) body, 14kbp downstream of TSS; GARS1-DT body, 509bp downstream of TSS. Process: diadenosine tetraphosphate biosynthetic process, tRNA aminoacylation for protein translation, mitochondrial glycyl-tRNA aminoacylation, glycyl-tRNA aminoacylation. Function: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity, ATP:ATP adenylyltransferase activity, aminoacyl-tRNA ligase activity, protein dimerization activity. Component: extracellular exosome, extracellular region, mitochondrial matrix, secretory granule. Beta: 0.01. | cg08872494 (chr1:113905172, +, CpG Island). In AP4B1 (adaptor related protein complex 4 subunit beta 1) body, 550bp downstream of TSS; DCLRE1B (DNA cross-link repair 1B) body, 769bp downstream of TSS. Process: protein localization to somatodendritic compartment, intracellular protein transport, vesicle-mediated transport, protein targeting. Function: clathrin binding, protein binding. Component: cytoplasmic side of trans-Golgi network transport vesicle membrane, clathrin adaptor complex, Golgi apparatus, endosome lumen. Process: double-strand break repair via nonhomologous end joining, protection from non-homologous end joining at telomere, telomere maintenance via telomere lengthening, telomeric 3' overhang formation. Function: protein-containing complex binding, protein homodimerization activity, 5'-3' DNA exonuclease activity, beta-lactamase activity. Component: chromosome, telomeric region, nuclear body, nucleoplasm, centrosome. Beta: 0.01. | cg08989932 (chr10:63630766, +, CpG Island). In ENSG00000286373 body (exon_1), 520bp downstream of TSS; ENSG00000307521 promoter, 714bp upstream of TSS. Beta: 0.01. | cg09037581 (chr20:62861825, +, CpG Island). In TCFL5 (transcription factor like 5) body, at TSS; ENSG00000302953 body (intron_1), 429bp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, regulation of cell population proliferation, cell differentiation, spermatogenesis. Function: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, protein dimerization activity. Component: chromatin, male germ cell nucleus, nucleoplasm, nucleus. Beta: 0.01. | cg09892203 (chr17:66965024, +, CpG Island). In CACNG4 (calcium voltage-gated channel auxiliary subunit gamma 4) body (exon_1), 317bp downstream of TSS; ENSG00000289877 promoter, 460bp upstream of TSS. Process: positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of synaptic transmission, glutamatergic, postsynaptic neurotransmitter receptor diffusion trapping, monoatomic ion transmembrane transport. Function: voltage-gated calcium channel activity, ionotropic glutamate receptor binding, protein binding, calcium channel regulator activity. Component: L-type voltage-gated calcium channel complex, AMPA glutamate receptor complex, monoatomic ion channel complex, postsynaptic density membrane. Beta: 0.01. | cg09969830 (chr16:53646, +, CpG Island). In POLR3K (RNA polymerase III subunit K) body, 12bp downstream of TSS; SNRNP25 (small nuclear ribonucleoprotein U11/U12 subunit 25) promoter, 182bp upstream of TSS. Process: transcription initiation at RNA polymerase III promoter, DNA-templated transcription, defense response to virus, innate immune response. Function: DNA-directed RNA polymerase activity, metal ion binding, nucleic acid binding, zinc ion binding. Component: DNA-directed RNA polymerase complex, nucleoplasm, cytosol, nucleus. Process: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosome conformational change to release U4 (or U4atac) and U1 (or U11). Function: protein binding. Component: U12-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex. Beta: 0.01. | cg12477533 (chr2:98086987, -, CpG Island). In VWA3B (von Willebrand factor A domain containing 3B) promoter, 129bp upstream of TSS. Component: cytoplasm, cytosol. Beta: 0.01. | cg12487497 (chr15:34337794, -, CpG Island). In SLC12A6 (solute carrier family 12 member 6) body, 266bp downstream of TSS; ENSG00000299794 promoter, 34bp upstream of TSS. Process: potassium ion import across plasma membrane, cellular response to glucose stimulus, potassium ion transmembrane transport, cellular hypotonic salinity response. Function: potassium ion transmembrane transporter activity, chloride:monoatomic cation symporter activity, protein kinase binding, metal ion binding. Component: basolateral plasma membrane, synapse, axon, apical plasma membrane. Beta: 0.01. | cg12600418 (chr1:37474322, -, CpG Island). In ZC3H12A (zinc finger CCCH-type containing 12A) promoter, 174bp upstream of TSS; LITATS1 body (exon_1), 110bp downstream of TSS. Process: negative regulation of cytokine production involved in inflammatory response, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, negative regulation of non-canonical NF-kappaB signal transduction, positive regulation of reactive oxygen species metabolic process. Function: cysteine-type deubiquitinase activity, mRNA 3'-UTR AU-rich region binding, RNA endonuclease activity, RNA stem-loop binding. Component: cytoplasmic ribonucleoprotein granule, rough endoplasmic reticulum membrane, protein-containing complex, cytoskeleton. Beta: 0.01. | cg12832498 (chr13:110706180, +, CpG Island). In CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial) body, 7kbp downstream of TSS. Process: cysteinyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation. Function: aminoacyl-tRNA ligase activity, nucleotide binding, metal ion binding, ATP binding. Component: cytoplasm, mitochondrion. Beta: 0.01. | cg13685727 (chr9:87974615, -, CpG Island). In CDK20 (cyclin dependent kinase 20) body, 149bp downstream of TSS; ENSG00000303962 body (exon_1), 8bp downstream of TSS. Process: cell division, regulation of cell cycle. Function: cyclin-dependent protein serine/threonine kinase activity, transferase activity, nucleotide binding, protein binding. Component: cilium, cytoplasm, nucleoplasm, nucleus. Beta: 0.01. | cg13724379 (chr3:187739926, +, N_Shore 18bp). In BCL6 (BCL6 transcription repressor) body (intron_1), 6kbp downstream of TSS. Process: negative regulation of mitotic cell cycle DNA replication, negative regulation of transcription by RNA polymerase II, positive regulation of regulatory T cell differentiation, regulation of leukocyte cell-cell adhesion. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, identical protein binding. Component: nucleoplasm, nucleus, paraspeckles, replication fork. Beta: 0.01. | cg17473923 (chr12:89351701, +, CpG Island). In DUSP6 (dual specificity phosphatase 6) body (exon_1), 800bp downstream of TSS; ENSG00000274021 body (exon_1), 686bp downstream of TSS. Process: negative regulation of ERK1 and ERK2 cascade, positive regulation of apoptotic process, peptidyl-tyrosine dephosphorylation, response to xenobiotic stimulus. Function: MAP kinase tyrosine/serine/threonine phosphatase activity, protein tyrosine/threonine phosphatase activity, hydrolase activity, protein binding. Component: cytoplasm, cytosol, nucleoplasm. Beta: 0.01. | cg17491548 (chr2:73385761, +, CpG Island). In ALMS1 (ALMS1 centrosome and basal body associated protein) body, 3bp downstream of TSS; ENSG00000285068 promoter, 70bp upstream of TSS. Process: endosomal transport, positive regulation of cold-induced thermogenesis, regulation of centriole replication, regulation of stress fiber assembly. Function: protein binding. Component: microtubule cytoskeleton, ciliary basal body, spindle pole, centrosome. Beta: 0.01. | cg17942639 (chr2:153478670, -, CpG Island). In RPRM (reprimo, TP53 dependent G2 arrest mediator homolog) body (exon_1), 92bp downstream of TSS; ENSG00000301085 body (intron_3), 845bp downstream of TSS. Process: regulation of cell cycle, regulation of mitotic cell cycle. Function: protein binding. Component: cytoplasm, membrane. Beta: 0.01. | cg17989428 (chr2:20052064, -, CpG Island). In LAPTM4A (lysosomal protein transmembrane 4 alpha) promoter, 371bp upstream of TSS; LAPTM4A-DT body, 264bp downstream of TSS. Process: regulation of lysosomal membrane permeability. Function: protein binding. Component: late endosome membrane, endomembrane system, lysosomal membrane, Golgi apparatus. Beta: 0.01. | cg19389001 (chr3:122921931, +, CpG Island). In SEMA5B (semaphorin 5B) body (exon_12), 107kbp downstream of TSS. Process: positive regulation of cell migration, semaphorin-plexin signaling pathway, neural crest cell migration, nervous system development. Function: chemorepellent activity, semaphorin receptor binding. Component: cytosol, membrane, plasma membrane. Beta: 0.01. | cg19631443 (chr10:28532301, +, CpG Island). In WAC (WW domain containing adaptor with coiled-coil) promoter, 192bp upstream of TSS; WAC-AS1 body (intron_1), 765bp downstream of TSS. Process: negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of DNA-templated transcription, mitotic G1 DNA damage checkpoint signaling, chromatin organization. Function: RNA polymerase II complex binding, chromatin binding, protein binding. Component: nuclear speck, nucleoplasm, nucleus, spliceosomal complex. Beta: 0.01. | cg20489026 (chr1:160084141, +, CpG Island). In KCNJ9 (potassium inwardly rectifying channel subfamily J member 9) body (exon_2), 3kbp downstream of TSS. Process: regulation of presynaptic membrane potential, potassium ion import across plasma membrane, monoatomic ion transmembrane transport, monoatomic ion transport. Function: G-protein activated inward rectifier potassium channel activity, inward rectifier potassium channel activity, ligand-gated monoatomic cation channel activity, protein binding. Component: inward rectifier potassium channel complex, parallel fiber to Purkinje cell synapse, monoatomic ion channel complex, presynaptic membrane. Beta: 0.01. | cg20496693 (chr7:1137999, +, CpG Island). In CHLSN (cholesin) body (exon_1), 314bp downstream of TSS. Process: negative regulation of cholesterol biosynthetic process, signal transduction. Function: RNA binding, hormone activity, protein binding. Component: extracellular region, extracellular space. Beta: 0.01. | cg20603637 (chr8:42152624, -, CpG Island). In AP3M2 (adaptor related protein complex 3 subunit mu 2) promoter, 322bp upstream of TSS; ENSG00000261449 body (exon_1), 139bp downstream of TSS. Process: clathrin-coated vesicle cargo loading, AP-3-mediated, anterograde synaptic vesicle transport, intracellular protein transport, Golgi to vacuole transport. Function: AP-3 adaptor complex binding, clathrin-cargo adaptor activity, protein binding. Component: AP-type membrane coat adaptor complex, cytoplasmic vesicle membrane, glutamatergic synapse, trans-Golgi network. Beta: 0.01. | cg21826815 (chr12:116881027, +, CpG Island). In HRK (harakiri, BCL2 interacting protein) body (exon_1), 414bp downstream of TSS; ENSG00000297968 body (intron_1), 2kbp downstream of TSS. Process: positive regulation of release of cytochrome c from mitochondria, positive regulation of protein-containing complex assembly, positive regulation of neuron apoptotic process, cellular response to potassium ion starvation. Function: protein binding. Component: membrane, mitochondrion. Beta: 0.01. | cg22521356 (chr7:25180357, -, CpG Island). In SPMIP4 (sperm microtubule inner protein 4) promoter, 1bp upstream of TSS; ENSG00000296268 body (intron_3), 155kbp downstream of TSS. Function: protein binding. Component: centrosome. Beta: 0.01. | cg22813794 (chr7:76048151, +, CpG Island). In MDH2 (malate dehydrogenase 2) body (exon_1), 101bp downstream of TSS; STYXL1 (serine/threonine/tyrosine interacting like 1) body, 658bp downstream of TSS. Process: carboxylic acid metabolic process, malate-aspartate shuttle, tricarboxylic acid cycle, aerobic respiration. Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, L-malate dehydrogenase (NADP+) activity, identical protein binding, oxidoreductase activity. Component: extracellular exosome, mitochondrial matrix, mitochondrion, cytoplasm. Process: positive regulation of intrinsic apoptotic signaling pathway, positive regulation of neuron projection development, negative regulation of stress granule assembly, intracellular signal transduction. Function: phosphatase inhibitor activity, protein binding, protein phosphatase binding, pseudophosphatase activity. Component: mitochondrial matrix, mitochondrion. Beta: 0.01. | cg23878564 (chr17:7384130, +, CpG Island). In TNK1 (tyrosine kinase non receptor 1) body (exon_6), 4kbp downstream of TSS. Process: protein autophosphorylation, protein phosphorylation. Function: non-membrane spanning protein tyrosine kinase activity, transferase activity, nucleotide binding, protein binding. Component: cytoplasm, membrane, plasma membrane. Beta: 0.01. | cg24187352 (chr11:356313, +, CpG Island). Intergenic. Beta: 0.01. | cg26005578 (chr11:13009129, -, CpG Island). In RASSF10 (Ras association domain family member 10) promoter, 187bp upstream of TSS; RASSF10-DT body (exon_1), 30bp downstream of TSS. Process: nervous system development, positive regulation of neural precursor cell proliferation, positive regulation of neurogenesis, signal transduction. Function: protein binding. Component: centrosome, cytosol, spindle pole. Beta: 0.01. | cg00108164 (chr2:264199, +, CpG Island). In ACP1 (acid phosphatase 1) body, 59bp downstream of TSS; SH3YL1 (SH3 and SYLF domain containing 1) body, 2kbp downstream of TSS. Process: chemical synaptic transmission. Function: non-membrane spanning protein tyrosine phosphatase activity, SH3 domain binding, hydrolase activity, protein binding. Component: cytoplasmic side of plasma membrane, extracellular exosome, sarcolemma, cytoplasm. Process: regulation of ruffle assembly. Function: phosphatase binding, phosphatidylinositol binding, protein binding. Component: ruffle membrane. Beta: 0.02. | cg00261781 (chr2:20012756, +, CpG Island). In MATN3 (matrilin 3) promoter, 87bp upstream of TSS. Process: extracellular matrix organization, skeletal system development. Function: calcium ion binding, extracellular matrix structural constituent, protein binding. Component: endoplasmic reticulum lumen, extracellular matrix, extracellular region. Beta: 0.02. | cg00287370 (chr1:234600346, -, CpG Island). In ENSG00000309433 body (exon_1), 88bp downstream of TSS; ENSG00000289057 promoter, 289bp upstream of TSS. Beta: 0.02. | cg00401091 (chr20:51542997, -, S_Shore 27bp). In NFATC2 (nuclear factor of activated T cells 2) body, 20kbp downstream of TSS; ENSG00000304242 body (intron_1), 152bp downstream of TSS. Process: negative regulation of vascular associated smooth muscle cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of B cell proliferation, calcineurin-NFAT signaling cascade. Function: DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, molecular adaptor activity. Component: transcription regulator complex, ribonucleoprotein complex, nucleoplasm, chromatin. Beta: 0.02. | cg00770871 (chr12:2890674, +, CpG Island). In TULP3 (TUB like protein 3) body, 13kbp downstream of TSS. Process: regulation of G protein-coupled receptor signaling pathway, protein localization to non-motile cilium, regulation of DNA-templated transcription, intraciliary anterograde transport. Function: phosphatidylinositol-4,5-bisphosphate binding, intraciliary transport particle A binding, protein-macromolecule adaptor activity, G protein-coupled receptor binding. Component: ciliary transition zone, 9+0 non-motile cilium, extracellular region, plasma membrane. Beta: 0.02. | cg00870265 (chr19:912831, +, CpG Island). In R3HDM4 (R3H domain containing 4) body (intron_1), 414bp downstream of TSS. Function: nucleic acid binding. Component: nucleus. Beta: 0.02. | cg01044608 (chr19:57320466, -, CpG Island). In ZNF543 (zinc finger protein 543) promoter, 6bp upstream of TSS. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Component: nucleus. Beta: 0.02. | cg01077609 (chr1:88684361, +, CpG Island). In PKN2 (protein kinase N2) body (exon_1), 139bp downstream of TSS; PKN2-AS1 body, 1kbp downstream of TSS. Process: vascular endothelial cell response to laminar fluid shear stress, positive regulation of viral genome replication, positive regulation of mitotic cell cycle, intracellular signal transduction. Function: diacylglycerol-dependent serine/threonine kinase activity, protein tyrosine kinase activity, histone deacetylase binding, RNA polymerase binding. Component: intermediate filament cytoskeleton, perinuclear region of cytoplasm, protein-containing complex, apical junction complex. Beta: 0.02. | cg01185855 (chr3:9933824, -, CpG Island). In CRELD1 (CRELD disulfide isomerase 1) body, 31bp downstream of TSS; ENSG00000288550 body (intron_16), 17kbp downstream of TSS. Process: cardiac septum development, endocardial cushion development. Function: extracellular matrix structural constituent, protein disulfide isomerase activity, calcium ion binding, protein binding. Component: glutamatergic synapse, extracellular matrix, extracellular space, membrane. Beta: 0.02. | cg01391867 (chr7:99500248, +, CpG Island). In ZKSCAN5 (zinc finger with KRAB and SCAN domains 5) promoter, 150bp upstream of TSS; ZNF394 (zinc finger protein 394) body (exon_1), 5kbp downstream of TSS. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, DNA-binding transcription factor activity. Component: nucleus. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Component: nucleoplasm, nucleus. Beta: 0.02. | cg01446983 (chr17:49677614, +, CpG Island). In SPOP (speckle type BTB/POZ protein) body (intron_1), 587bp downstream of TSS. Process: proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of proteolysis. Function: identical protein binding, molecular function inhibitor activity, protein binding, ubiquitin protein ligase binding. Component: Cul3-RING ubiquitin ligase complex, nuclear speck, nucleoplasm, cytoplasm. Beta: 0.02. | cg01509843 (chr8:142614461, -, CpG Island). In ARC (activity regulated cytoskeleton associated protein) body (exon_1), 18bp downstream of TSS; ENSG00000277332 promoter, 265bp upstream of TSS. Process: regulation of postsynaptic neurotransmitter receptor internalization, regulation of long-term synaptic potentiation, modulation of chemical synaptic transmission, regulation of dendritic spine morphogenesis. Function: RNA binding, mRNA binding, protein binding, structural molecule activity. Component: neuronal ribonucleoprotein granule, clathrin-coated vesicle membrane, early endosome membrane, extracellular vesicle. Beta: 0.02. | cg01532168 (chr8:139703314, +, CpG Island). In KCNK9 (potassium two pore domain channel subfamily K member 9) body, 795bp downstream of TSS; ENSG00000296434 body (intron_1), 682bp downstream of TSS. Process: negative regulation of aldosterone secretion, potassium ion import across plasma membrane, regulation of action potential firing rate, monoatomic ion transmembrane transport. Function: outward rectifier potassium channel activity, protein heterodimerization activity, identical protein binding, metal ion binding. Component: mitochondrial inner membrane, synaptic vesicle, plasma membrane, dendrite. Beta: 0.02. | cg01619129 (chr8:10839507, +, CpG Island). In PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1) body (intron_1), 377bp downstream of TSS; PINX1-DT body, 401bp downstream of TSS. Process: negative regulation of telomere maintenance via telomere lengthening, negative regulation of G2/M transition of mitotic cell cycle, positive regulation of protein localization to nucleolus, protein localization to chromosome, telomeric region. Function: protein-containing complex binding, telomerase inhibitor activity, telomerase RNA binding, nucleic acid binding. Component: chromosome, telomeric region, nuclear chromosome, kinetochore, nucleoplasm. Beta: 0.02. | cg01639032 (chr6:31815252, -, CpG Island). In HSPA1A (heat shock protein family A (Hsp70) member 1A) promoter, 291bp upstream of TSS; HSPA1L (heat shock protein family A (Hsp70) member 1 like) body (exon_1), 536bp downstream of TSS. Process: negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Function: ATP-dependent protein disaggregase activity, transcription regulator inhibitor activity, C3HC4-type RING finger domain binding, G protein-coupled receptor binding. Component: perinuclear region of cytoplasm, ficolin-1-rich granule lumen, protein-containing complex, ribonucleoprotein complex. Process: positive regulation of protein localization to mitochondrion, protein refolding, response to stress, response to unfolded protein. Function: ubiquitin protein ligase binding, heat shock protein binding, protein folding chaperone, ATP hydrolysis activity. Component: zona pellucida receptor complex, blood microparticle, COP9 signalosome, plasma membrane. Beta: 0.02. | cg01823956 (chr14:101761873, +, CpG Island). In PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma) body (exon_1), 191bp downstream of TSS; ENSG00000289049 promoter, 388bp upstream of TSS. Process: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, proteasome-mediated ubiquitin-dependent protein catabolic process, negative regulation of cell population proliferation, meiotic sister chromatid cohesion. Function: protein binding, protein phosphatase activator activity, protein phosphatase regulator activity. Component: protein phosphatase type 2A complex, chromosome, centromeric region, nucleoplasm, cytosol. Beta: 0.02. | cg01845244 (chr6:7911007, +, CpG Island). In TXNDC5 (thioredoxin domain containing 5) body, 4bp downstream of TSS; BLOC1S5-TXNDC5 (BLOC1S5-TXNDC5 readthrough (NMD candidate)) body (intron_4), 153kbp downstream of TSS. Process: negative regulation of apoptotic process, protein folding. Function: protein disulfide isomerase activity, protein-disulfide reductase activity, oxidoreductase activity, protein binding. Component: intracellular organelle lumen, endoplasmic reticulum lumen, azurophil granule lumen, extracellular exosome. Beta: 0.02. | cg01956624 (chr2:231037701, -, CpG Island). In C2orf72 (chromosome 2 open reading frame 72) body (exon_1), 359bp downstream of TSS. Beta: 0.02. | cg01971089 (chr19:4400706, -, CpG Island). In SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2) promoter, 159bp upstream of TSS. Process: central nervous system development, synaptic vesicle endocytosis, membrane organization, signal transduction. Function: protein-macromolecule adaptor activity, identical protein binding, cadherin binding, lipid binding. Component: early endosome membrane, glutamatergic synapse, presynapse, cytoplasm. Beta: 0.02. | cg02189786 (chr16:67842056, +, CpG Island). In THAP11 (THAP domain containing 11) promoter, 264bp upstream of TSS; CENPT (centromere protein T) body (intron_1), 6kbp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, metal ion binding, protein binding. Component: chromatin, cytoplasm, nucleoplasm, nucleus. Process: chromosome organization, chromosome segregation, kinetochore assembly, mitotic cell cycle. Function: DNA binding, protein binding, protein heterodimerization activity. Component: chromosome, centromeric region, nuclear body, kinetochore, nucleoplasm. Beta: 0.02. | cg02331561 (chr16:2341080, +, CpG Island). In ABCA3 (ATP binding cassette subfamily A member 3) promoter, 331bp upstream of TSS; ABCA17P body (exon_1), 2kbp downstream of TSS. Process: regulation of phosphatidylcholine metabolic process, positive regulation of protein homooligomerization, xenobiotic transmembrane transport, response to xenobiotic stimulus. Function: ATPase-coupled intramembrane lipid transporter activity, ABC-type xenobiotic transporter activity, phosphatidylcholine flippase activity, ATP hydrolysis activity. Component: intracellular membrane-bounded organelle, alveolar lamellar body membrane, cytoplasmic vesicle membrane, late endosome membrane. Beta: 0.02. | cg02403541 (chr12:121016485, +, CpG Island). In C12orf43 (chromosome 12 open reading frame 43) body (exon_1), 19bp downstream of TSS. Process: Spemann organizer formation, Wnt signaling pathway, negative regulation of Wnt signaling pathway. Function: protein binding. Component: nuclear envelope, nucleolus. Beta: 0.02. | cg02444300 (chr19:48110574, -, OpenSea). In PLA2G4C (phospholipase A2 group IVC) body (exon_1), 276bp downstream of TSS. Process: platelet activating factor biosynthetic process, phosphatidylethanolamine acyl-chain remodeling, glycerophospholipid catabolic process, intracellular signal transduction. Function: phosphatidylcholine lysophospholipase A1 activity, glycerophospholipid phospholipase A1 activity, calcium-dependent phospholipid binding, A2-type glycerophospholipase activity. Component: endoplasmic reticulum membrane, mitochondrial membrane, nuclear envelope, plasma membrane. Beta: 0.02. | cg02712555 (chr20:54174194, -, CpG Island). In CYP24A1 (cytochrome P450 family 24 subfamily A member 1) promoter, 208bp upstream of TSS; ENSG00000286587 body (intron_3), 115kbp downstream of TSS. Process: calcitriol biosynthetic process from calciol, vitamin D receptor signaling pathway, small molecule biosynthetic process, cellular response to vitamin D. Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity, 25-hydroxycholecalciferol-23-hydroxylase activity, 25-hydroxycholecalciferol-24-hydroxylase activity. Component: mitochondrial inner membrane, mitochondrion. Beta: 0.02. | cg02728595 (chr3:196528761, -, CpG Island). In NAA50P2 body (exon_1), 30bp downstream of TSS; ENSG00000308888 promoter, 224bp upstream of TSS. Beta: 0.02. | cg02810156 (chr19:36331770, +, CpG Island). In LINC00665 body, at TSS. Beta: 0.02. | cg02848777 (chr10:96513957, -, CpG Island). In TLL2 (tolloid like 2) promoter, 16bp upstream of TSS. Process: dorsal/ventral pattern formation, collagen fibril organization, cell differentiation, protein processing. Function: serine-type endopeptidase activity, metalloendopeptidase activity, metallopeptidase activity, calcium ion binding. Component: extracellular region, extracellular space. Beta: 0.02. | cg02853322 (chr7:39950124, -, CpG Island). In CDK13 (cyclin dependent kinase 13) body, 3bp downstream of TSS; CDK13-DT promoter, 147bp upstream of TSS. Process: positive regulation of transcription elongation by RNA polymerase II, alternative mRNA splicing, via spliceosome, regulation of signal transduction, regulation of cell cycle. Function: RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activity, transferase activity, nucleotide binding. Component: cyclin/CDK positive transcription elongation factor complex, nuclear cyclin-dependent protein kinase holoenzyme complex, ficolin-1-rich granule lumen, cyclin K-CDK13 complex. Beta: 0.02. | cg02991799 (chr19:34677605, -, CpG Island). In SCGB2B2 (secretoglobin family 2B member 2) promoter, 446bp upstream of TSS; ZNF302 (zinc finger protein 302) body, 521bp downstream of TSS. Function: protein binding. Component: extracellular region. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Component: nucleus. Beta: 0.02. | cg03054303 (chr16:1612300, -, CpG Island). In CRAMP1 (cramped chromatin regulator 1) promoter, 37bp upstream of TSS; IFT140 (intraflagellar transport 140) promoter, 225bp upstream of TSS. Process: pattern specification process, positive regulation of DNA-templated transcription. Function: DNA binding, DNA-binding transcription factor activity, chromatin binding. Component: chromosome, histone locus body, nucleus. Process: protein localization to non-motile cilium, intraciliary anterograde transport, regulation of cilium assembly, cell projection organization. Function: protein binding, protein carrier chaperone. Component: intraciliary transport particle A, photoreceptor connecting cilium, photoreceptor outer segment, ciliary basal body. Beta: 0.02. | cg03098356 (chr6:87155596, -, CpG Island). In ZNF292 (zinc finger protein 292) body (exon_1), 4kbp downstream of TSS; ENSG00000272008 promoter, 105bp upstream of TSS. Process: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription activator activity, RNA polymerase II-specific, metal ion binding, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific. Component: nucleus. Beta: 0.02. | cg03110633 (chr19:35000361, -, CpG Island). In GRAMD1A (GRAM domain containing 1A) body (exon_1), 6kbp downstream of TSS; GRAMD1A-AS1 promoter, 146bp upstream of TSS. Process: autophagy, intracellular cholesterol transport, intracellular sterol transport, lipid transport. Function: cholesterol binding, cholesterol transfer activity, lipid binding, protein binding. Component: endoplasmic reticulum-plasma membrane contact site, cytoplasmic vesicle, plasma membrane, autophagosome. Beta: 0.02. | cg03208951 (chr19:48325578, +, S_Shelf 3342bp). In EMP3 (epithelial membrane protein 3 (MAM blood group)) body (exon_1), 4kbp downstream of TSS. Process: apoptotic process, bleb assembly. Function: protein binding. Component: membrane, plasma membrane. Beta: 0.02. | cg03274876 (chr4:169757855, +, CpG Island). In HPF1 (histone PARylation factor 1) body (exon_1), 89bp downstream of TSS; ENSG00000295852 promoter, 160bp upstream of TSS. Process: DNA repair-dependent chromatin remodeling, regulation of protein ADP-ribosylation, double-strand break repair, DNA damage response. Function: protein ADP-ribosyltransferase-substrate adaptor activity, poly-ADP-D-ribose binding, chromatin binding, histone binding. Component: chromatin, chromosome, nucleus, site of DNA damage. Beta: 0.02. | cg03306486 (chr19:1467953, +, CpG Island). In C19orf25 (chromosome 19 open reading frame 25) body, 12kbp downstream of TSS; APC2 (APC regulator of Wnt signaling pathway 2) body (exon_15), 22kbp downstream of TSS. Function: protein binding. Process: proteasome-mediated ubiquitin-dependent protein catabolic process, negative regulation of canonical Wnt signaling pathway, microtubule cytoskeleton organization, activation of GTPase activity. Function: beta-catenin binding, gamma-catenin binding, microtubule binding, protein binding. Component: plasma membrane bounded cell projection, beta-catenin destruction complex, perinuclear region of cytoplasm, microtubule cytoskeleton. Beta: 0.02. | cg03527353 (chr11:31811166, +, CpG Island). In ENSG00000285283 promoter, 1kbp upstream of TSS; PAX6 (paired box 6) body (exon_1), 7kbp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, positive regulation of gene expression, type B pancreatic cell differentiation, cornea development in camera-type eye. Function: DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, histone acetyltransferase binding. Component: chromatin, cytoplasm, nucleoplasm, nucleus. Beta: 0.02. | cg03603214 (chr1:48777085, +, CpG Island). In BEND5 (BEN domain containing 5) promoter, 116bp upstream of TSS; AGBL4 (AGBL carboxypeptidase 4) body (intron_6), 1247kbp downstream of TSS. Process: negative regulation of DNA-templated transcription. Function: DNA binding, protein binding. Component: Golgi apparatus. Process: defense response to virus, proteolysis. Function: metallocarboxypeptidase activity, carboxypeptidase activity, metallopeptidase activity, hydrolase activity. Component: microtubule cytoskeleton, ciliary basal body, Golgi apparatus, centriole. Beta: 0.02. | cg03607359 (chr5:176630464, -, CpG Island). In EIF4E1B (eukaryotic translation initiation factor 4E family member 1B) promoter, 118bp upstream of TSS; SNCB (synuclein beta) body (exon_1), 208bp downstream of TSS. Process: regulation of translation, translation, translational initiation. Function: RNA 7-methylguanosine cap binding, RNA binding, protein binding, translation initiation factor activity. Component: cytoplasm, eukaryotic translation initiation factor 4F complex. Process: chemical synaptic transmission, synapse organization, synaptic vesicle endocytosis. Function: phospholipase inhibitor activity, transition metal ion binding, protein binding, calcium ion binding. Component: neuronal cell body, inclusion body, axon terminus, cytoplasm. Beta: 0.02. | cg03778669 (chr6:28489469, -, OpenSea). In ENSG00000287804 body (exon_1), 48bp downstream of TSS; ENSG00000286819 promoter, 110bp upstream of TSS. Beta: 0.02. | cg03848555 (chr9:74952445, -, CpG Island). In C9orf40 (chromosome 9 open reading frame 40) body (exon_1), 467bp downstream of TSS; CARNMT1-AS1 promoter, 523bp upstream of TSS. Beta: 0.02. | cg03965044 (chr17:50634851, -, CpG Island). In ABCC3 (ATP binding cassette subfamily C member 3) body, 242bp downstream of TSS; ENSG00000251239 body (intron_1), 4kbp downstream of TSS. Process: transport across blood-brain barrier, xenobiotic transmembrane transport, bile acid and bile salt transport, xenobiotic metabolic process. Function: ABC-type glutathione S-conjugate transporter activity, ATPase-coupled transmembrane transporter activity, ATP hydrolysis activity, nucleotide binding. Component: basal plasma membrane, basolateral plasma membrane, membrane, plasma membrane. Beta: 0.02. | cg04154825 (chr3:122564405, +, CpG Island). In DTX3L (deltex E3 ubiquitin ligase 3L) body (exon_1), 67bp downstream of TSS; PARP9 (poly(ADP-ribose) polymerase family member 9) body, 1kbp downstream of TSS. Process: negative regulation of ubiquitin-protein transferase activity, positive regulation of protein localization to early endosome, positive regulation of defense response to virus by host, positive regulation of receptor catabolic process. Function: protein ADP-ribosyltransferase-substrate adaptor activity, histone H4K91 ubiquitin ligase activity, ubiquitin-protein transferase activity, ubiquitin-like protein ligase binding. Component: protein-containing complex, early endosome membrane, lysosomal membrane, nucleoplasm. Process: positive regulation of type II interferon-mediated signaling pathway, positive regulation of tyrosine phosphorylation of STAT protein, negative regulation of transcription by RNA polymerase II, positive regulation of defense response to virus by host. Function: NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity, NAD+ poly-ADP-ribosyltransferase activity, ubiquitin-like protein ligase binding, transcription corepressor activity. Component: protein-containing complex, site of DNA damage, nucleoplasm, cytoplasm. Beta: 0.02. | cg04232649 (chr5:163437483, +, CpG Island). In CCNG1 (cyclin G1) promoter, 86bp upstream of TSS; ENSG00000254186 promoter, 46bp upstream of TSS. Process: G1/S transition of mitotic cell cycle, cell division, regulation of cyclin-dependent protein serine/threonine kinase activity. Function: cyclin-dependent protein serine/threonine kinase regulator activity, protein binding. Component: cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleoplasm, nucleus. Beta: 0.02. | cg04490108 (chr1:150364556, -, CpG Island). In RPRD2 (regulation of nuclear pre-mRNA domain containing 2) body (exon_1), 1kbp downstream of TSS. Process: mRNA 3'-end processing. Function: RNA polymerase II C-terminal domain binding, RNA polymerase II complex binding. Component: nucleoplasm, transcription preinitiation complex. Beta: 0.02. | cg04739306 (chr7:100633158, +, CpG Island). In TFR2 (transferrin receptor 2) body (intron_5), 10kbp downstream of TSS. Process: positive regulation of transcription by RNA polymerase II, multicellular organismal-level iron ion homeostasis, positive regulation of peptide hormone secretion, endocytic iron import into cell. Function: co-receptor binding, protein binding, transferrin receptor activity. Component: HFE-transferrin receptor complex, external side of plasma membrane, cytoplasmic vesicle, cytoplasm. Beta: 0.02. | cg04794120 (chr7:47979608, +, CpG Island). In HUS1 (HUS1 checkpoint clamp component) body (exon_1), 74bp downstream of TSS; ENSG00000300483 body (intron_1), 226bp downstream of TSS. Process: double-strand break repair via homologous recombination, embryo development ending in birth or egg hatching, mitotic intra-S DNA damage checkpoint signaling, cellular response to ionizing radiation. Function: protein binding. Component: site of double-strand break, checkpoint clamp complex, nucleoplasm, nucleolus. Beta: 0.02. | cg04845144 (chr19:45496541, +, CpG Island). In RTN2 (reticulon 2) body (intron_1), 514bp downstream of TSS; PPM1N (protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)) body, 8kbp downstream of TSS. Process: endoplasmic reticulum tubular network membrane organization, regulation of D-glucose import across plasma membrane, intracellular protein transmembrane transport, negative regulation of amyloid-beta formation. Function: protein binding. Component: sarcoplasmic reticulum membrane, endoplasmic reticulum, intermediate filament, postsynaptic density. Process: positive regulation of canonical Wnt signaling pathway, regulation of canonical NF-kappaB signal transduction. Function: protein serine/threonine phosphatase activity, magnesium ion binding, hydrolase activity, phosphoprotein phosphatase activity. Component: cytosol, nucleus. Beta: 0.02. | cg04863182 (chr15:81324345, +, CpG Island). In STARD5 (StAR related lipid transfer domain containing 5) promoter, 162bp upstream of TSS; TMC3-AS1 body, 44bp downstream of TSS. Process: bile acid and bile salt transport, cholesterol import, lipid transport. Function: bile acid binding, cholesterol binding, cholesterol transfer activity, lipid binding. Component: cytosol. Beta: 0.02. | cg05003422 (chr1:85048206, +, CpG Island). In MCOLN3 (mucolipin TRP cation channel 3) body (intron_1), 473bp downstream of TSS; DNAI3 (dynein axonemal intermediate chain 3) body, 49kbp downstream of TSS. Process: monoatomic anion transmembrane transport, potassium ion transmembrane transport, calcium-mediated signaling, monoatomic ion transmembrane transport. Function: NAADP-sensitive calcium-release channel activity, monoatomic cation channel activity, lipid binding, monoatomic anion channel activity. Component: early endosome membrane, autophagosome membrane, cytoplasmic vesicle, lysosomal membrane. Process: negative regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of osteoblast differentiation, cilium movement involved in cell motility, inner dynein arm assembly. Function: Arp2/3 complex binding, dynein heavy chain binding, dynein light chain binding, protein binding. Component: axonemal dynein complex, cytoplasm, inner dynein arm. Beta: 0.02. | cg05088677 (chr10:21496804, +, CpG Island). In MIR1915 promoter, 163bp upstream of TSS; MIR1915HG body (exon_1), 456bp downstream of TSS. Beta: 0.02. | cg05189291 (chr5:157731449, -, CpG Island). In THG1L (tRNA-histidine guanylyltransferase 1 like) body (exon_1), 37bp downstream of TSS; ENSG00000309117 body (intron_1), 235bp downstream of TSS. Process: stress-induced mitochondrial fusion, response to oxidative stress, protein homotetramerization, tRNA 5'-end processing. Function: guanyl-nucleotide exchange factor activity, tRNA guanylyltransferase activity, nucleotidyltransferase activity, identical protein binding. Component: mitochondrial outer membrane, transferase complex, mitochondrion, cytoplasm. Beta: 0.02. | cg05492270 (chr11:71929039, -, OpenSea). In RNF121 (ring finger protein 121) body, 21bp downstream of TSS; XNDC1N-ZNF705EP-ALG1L9P (XNDC1N-ZNF705EP-ALG1L9P readthrough) promoter, 383bp upstream of TSS. Process: ERAD pathway, protein ubiquitination. Function: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding. Component: Golgi membrane, endoplasmic reticulum membrane. Beta: 0.02. | cg05496738 (chr2:25878687, +, CpG Island). In ASXL2 (ASXL transcriptional regulator 2) promoter, 200bp upstream of TSS. Process: positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II, positive regulation of fat cell differentiation, animal organ morphogenesis. Function: peroxisome proliferator activated receptor binding, chromatin binding, metal ion binding, protein binding. Component: PR-DUB complex, nucleoplasm, nucleus. Beta: 0.02. | cg05676377 (chr6:26383445, +, OpenSea). In BTN2A2 (butyrophilin subfamily 2 member A2) body (intron_1), 353bp downstream of TSS; ENSG00000291338 body, 226kbp downstream of TSS. Process: T cell receptor signaling pathway, negative regulation of activated T cell proliferation, negative regulation of cytokine production, regulation of cytokine production. Function: protein binding, signaling receptor binding. Component: cell surface, external side of plasma membrane, membrane, plasma membrane. Beta: 0.02. | cg05770238 (chr1:26360096, +, CpG Island). In CRYBG2 (crystallin beta-gamma domain containing 2) promoter, 16bp upstream of TSS. Function: carbohydrate binding. Beta: 0.02. || Highest methylated (100 sites): cg00474840 (chr19:18010010, +, CpG Island). In ARRDC2 (arrestin domain containing 2) body (exon_5), 9kbp downstream of TSS; ENSG00000279172 promoter, 129bp upstream of TSS. Function: molecular adaptor activity, protein binding. Component: cytoplasm, cytoplasmic vesicle, plasma membrane. Beta: 0.99. | cg01495521 (chr16:928040, +, N_Shore 1383bp). In LMF1 (lipase maturation factor 1) body (intron_3), 53kbp downstream of TSS; LMF1-AS1 body (intron_1), 7kbp downstream of TSS. Process: protein maturation, triglyceride metabolic process. Component: endoplasmic reticulum membrane. Beta: 0.99. | cg02399044 (chr12:2391063, +, OpenSea). In CACNA1C (calcium voltage-gated channel subunit alpha1 C) body (intron_3), 420kbp downstream of TSS. Process: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, calcium ion transmembrane transport via high voltage-gated calcium channel, membrane depolarization during atrial cardiac muscle cell action potential, cell communication by electrical coupling involved in cardiac conduction. Function: voltage-gated calcium channel activity involved in cardiac muscle cell action potential, monoatomic ion channel activity, alpha-actinin binding, calmodulin binding. Component: L-type voltage-gated calcium channel complex, monoatomic ion channel complex, postsynaptic density membrane, plasma membrane. Beta: 0.99. | cg03353885 (chr13:112835078, +, S_Shelf 2045bp). In ATP11A (ATPase phospholipid transporting 11A) body (intron_15), 145kbp downstream of TSS; ENSG00000303208 body (intron_1), 2kbp downstream of TSS. Process: positive regulation of myotube differentiation, regulation of membrane lipid distribution, aminophospholipid translocation, phospholipid translocation. Function: ATPase-coupled intramembrane lipid transporter activity, phosphatidylethanolamine flippase activity, phosphatidylserine floppase activity, ATP hydrolysis activity. Component: phospholipid-translocating ATPase complex, endoplasmic reticulum membrane, specific granule membrane, endomembrane system. Beta: 0.99. | cg03483654 (chr11:61334602, -, S_Shore 1102bp). In TKFC (triokinase and FMN cyclase) body (intron_1), 1kbp downstream of TSS; DDB1 (damage specific DNA binding protein 1) body, 8kbp downstream of TSS. Process: fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate, negative regulation of MDA-5 signaling pathway, regulation of innate immune response, carbohydrate metabolic process. Function: FAD-AMP lyase (cyclizing) activity, glycerone kinase activity, transferase activity, triokinase activity. Component: cytosol, extracellular exosome, nucleus. Process: positive regulation by virus of viral protein levels in host cell, proteasome-mediated ubiquitin-dependent protein catabolic process, biological process involved in interaction with symbiont, regulation of DNA-templated DNA replication initiation. Function: ubiquitin ligase complex scaffold activity, protein-macromolecule adaptor activity, protein-containing complex binding, cullin family protein binding. Component: Cul4A-RING E3 ubiquitin ligase complex, chromosome, telomeric region, site of double-strand break, protein-containing complex. Beta: 0.99. | cg04998671 (chr14:103534168, +, N_Shore 383bp). In TRMT61A (tRNA methyltransferase 61A) body (intron_3), 13kbp downstream of TSS. Process: tRNA methylation, mRNA processing, tRNA processing, RNA processing. Function: tRNA (adenine(58)-N1)-methyltransferase activity, mRNA (adenine-N1-)-methyltransferase activity, methyltransferase activity, transferase activity. Component: nucleoplasm, nucleus, tRNA (m1A) methyltransferase complex. Beta: 0.99. | cg05184586 (chr17:42113809, -, N_Shelf 3574bp). In DHX58 (DExH-box helicase 58) promoter, 1kbp upstream of TSS; KAT2A (lysine acetyltransferase 2A) body (exon_18), 8kbp downstream of TSS. Process: cytoplasmic pattern recognition receptor signaling pathway, negative regulation of type I interferon production, negative regulation of MDA-5 signaling pathway, negative regulation of innate immune response. Function: double-stranded RNA binding, ATP hydrolysis activity, RNA helicase activity, hydrolase activity. Component: Golgi apparatus, cytoplasm, cytosol. Process: negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process, positive regulation of cardiac muscle cell differentiation, negative regulation of transcription by RNA polymerase II, cellular response to nerve growth factor stimulus. Function: acyltransferase activity, transferring groups other than amino-acyl groups, histone H1-4K34 acetyltransferase activity, protein-lysine-acetyltransferase activity, DNA-binding transcription factor binding. Component: oxoglutarate dehydrogenase complex, histone acetyltransferase complex, transcription factor TFTC complex, extracellular space. Beta: 0.99. | cg06662140 (chr1:18482803, -, CpG Island). In KLHDC7A (kelch domain containing 7A) body (exon_1), 2kbp downstream of TSS. Function: protein binding. Component: membrane. Beta: 0.99. | cg06845706 (chr22:23391625, +, S_Shelf 3275bp). In CCDC188BP promoter, 928bp upstream of TSS; ENSG00000309931 body (intron_1), 3kbp downstream of TSS. Beta: 0.99. | cg06911753 (chr11:47589684, -, CpG Island). In C1QTNF4 (C1q and TNF related 4) body (exon_2), 6kbp downstream of TSS. Process: positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of interleukin-6-mediated signaling pathway, positive regulation of tumor necrosis factor production, positive regulation of interleukin-6 production. Function: cytokine activity, protein binding. Component: extracellular region, extracellular space. Beta: 0.99. | cg07387931 (chr3:141066318, +, CpG Island). In SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4) body (exon_2), 16kbp downstream of TSS. Process: proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of protein polyubiquitination, intracellular signal transduction, regulation of circadian rhythm. Function: protein binding, ubiquitin-like ligase-substrate adaptor activity. Component: SCF ubiquitin ligase complex, cytoplasm, cytosol. Beta: 0.99. | cg07550554 (chr14:72929070, -, S_Shelf 2162bp). In DCAF4 (DDB1 and CUL4 associated factor 4) body (intron_1), 3kbp downstream of TSS. Process: cell population proliferation, protein ubiquitination. Function: protein binding. Component: Cul4-RING E3 ubiquitin ligase complex, nucleoplasm. Beta: 0.99. | cg07591937 (chr1:248848306, +, CpG Island). In ZNF672 (zinc finger protein 672) body (exon_4), 10kbp downstream of TSS. Process: regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific DNA binding, metal ion binding, protein binding. Component: nucleoplasm, nucleus. Beta: 0.99. | cg09207578 (chr13:114016473, -, CpG Island). In RASA3 (RAS p21 protein activator 3) body (intron_12), 116kbp downstream of TSS. Process: negative regulation of Ras protein signal transduction, platelet activation, response to stress, regulation of intracellular signal transduction. Function: GTPase activator activity, calcium channel regulator activity, metal ion binding, zinc ion binding. Component: cytoplasmic side of plasma membrane, cytosol, plasma membrane. Beta: 0.99. | cg12266049 (chr11:69646566, +, CpG Island). In CCND1 (cyclin D1) body (intron_3), 5kbp downstream of TSS. Process: positive regulation of G1/S transition of mitotic cell cycle, negative regulation of transcription by RNA polymerase II, mitotic G1 DNA damage checkpoint signaling, response to xenobiotic stimulus. Function: cyclin-dependent protein serine/threonine kinase activator activity, protein-containing complex binding, transcription corepressor activity, histone deacetylase binding. Component: cyclin-dependent protein kinase holoenzyme complex, transcription repressor complex, microtubule organizing center, bicellular tight junction. Beta: 0.99. | cg13914990 (chr12:120737075, +, N_Shelf 2238bp). In ACADS (acyl-CoA dehydrogenase short chain) body (exon_3), 11kbp downstream of TSS; ENSG00000255946 body (intron_1), 25kbp downstream of TSS. Process: fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid metabolic process, butyrate catabolic process, fatty acid beta-oxidation. Function: oxidoreductase activity, acting on the CH-CH group of donors, short-chain fatty acyl-CoA dehydrogenase activity, flavin adenine dinucleotide binding, oxidoreductase activity. Component: mitochondrial matrix, mitochondrion, nucleus. Beta: 0.99. | cg15142488 (chr19:41844884, -, CpG Island). In DMRTC2 (DMRT like family C2) body, 141bp downstream of TSS; LYPD4 (LY6/PLAUR domain containing 4) promoter, 187bp upstream of TSS. Process: cell differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, sex differentiation. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific double-stranded DNA binding, identical protein binding, metal ion binding. Component: XY body, chromatin, nucleus. Component: extracellular region, plasma membrane raft, acrosomal vesicle, side of membrane. Beta: 0.99. | cg15156844 (chr18:3880020, -, CpG Island). In DLGAP1 (DLG associated protein 1) body (exon_4), 575kbp downstream of TSS; DLGAP1-AS3 body (intron_1), 2kbp downstream of TSS. Process: chemical synaptic transmission, modulation of chemical synaptic transmission, signaling. Function: molecular adaptor activity, protein binding, protein-containing complex binding. Component: postsynaptic specialization, glutamatergic synapse, postsynaptic density, plasma membrane. Beta: 0.99. | cg16142349 (chr6:166497521, -, OpenSea). In RPS6KA2 (ribosomal protein S6 kinase A2) body (intron_8), 409kbp downstream of TSS. Process: negative regulation of cell population proliferation, positive regulation of apoptotic process, intracellular signal transduction, chemical synaptic transmission. Function: protein serine/threonine/tyrosine kinase activity, magnesium ion binding, transferase activity, nucleotide binding. Component: meiotic spindle, nucleoplasm, cytoplasm, cytosol. Beta: 0.99. | cg16369288 (chr3:44579234, +, CpG Island). In ZNF660 (zinc finger protein 660) body, 1kbp downstream of TSS; ZKSCAN7 (zinc finger with KRAB and SCAN domains 7) body, 24kbp downstream of TSS. Process: regulation of transcription by RNA polymerase II. Function: RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, metal ion binding, protein binding. Component: nucleus. Process: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Component: cytosol, nucleus. Beta: 0.99. | cg17016890 (chr18:48029801, -, CpG Island). In ZBTB7C (zinc finger and BTB domain containing 7C) body (exon_5), 381kbp downstream of TSS. Process: negative regulation of cell population proliferation, regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding. Component: nucleus. Beta: 0.99. | cg19199752 (chr21:44310353, -, CpG Island). In PFKL (phosphofructokinase, liver type) body (intron_2), 10kbp downstream of TSS. Process: fructose 1,6-bisphosphate metabolic process, canonical glycolysis, response to glucose, glycolytic process. Function: 6-phosphofructokinase activity, fructose-6-phosphate binding, identical protein binding, monosaccharide binding. Component: 6-phosphofructokinase complex, ficolin-1-rich granule lumen, extracellular exosome, extracellular region. Beta: 0.99. | cg19306958 (chr22:46386446, -, N_Shelf 2829bp). In CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1) body (exon_19), 151kbp downstream of TSS. Process: orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis, protein localization involved in establishment of planar polarity, Wnt signaling pathway, planar cell polarity pathway, establishment of body hair planar orientation. Function: G protein-coupled receptor activity, calcium ion binding, transmembrane signaling receptor activity. Component: adherens junction, membrane, plasma membrane. Beta: 0.99. | cg19721055 (chr19:12642515, +, CpG Island). Intergenic. Beta: 0.99. | cg20679271 (chr2:127592867, -, CpG Island). In MYO7B (myosin VIIB) body (exon_17), 57kbp downstream of TSS. Process: actin filament-based movement, actin filament organization, sensory perception of sound, sensory organ development. Function: microfilament motor activity, actin filament binding, nucleotide binding, protein binding. Component: stereocilia ankle link, actin cytoskeleton, apical cytoplasm, myosin complex. Beta: 0.99. | cg21010435 (chr7:157416188, +, CpG Island). In DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6) body (exon_10), 81kbp downstream of TSS. Process: negative regulation of inclusion body assembly, regulation of cellular response to heat, intermediate filament organization, regulation of protein localization. Function: protein-folding chaperone binding, heat shock protein binding, ATPase activator activity, protein folding chaperone. Component: perinuclear region of cytoplasm, nucleoplasm, membrane, cytosol. Beta: 0.99. | cg21564965 (chr17:38469939, -, OpenSea). In ARHGAP23 (Rho GTPase activating protein 23) body (intron_10), 51kbp downstream of TSS; ENSG00000276170 body, 159bp downstream of TSS. Process: regulation of small GTPase mediated signal transduction, signal transduction. Function: GTPase activator activity. Component: cytosol, extracellular exosome. Beta: 0.99. | cg21566513 (chr13:24338946, -, N_Shore 1465bp). In ENSG00000304432 body (intron_1), 299bp downstream of TSS. Beta: 0.99. | cg22857025 (chr5:266819, +, OpenSea). In ENSG00000286001 body (intron_16), 49kbp downstream of TSS. Beta: 0.99. | cg22896075 (chr17:40362161, +, N_Shore 553bp). In GJD3 (gap junction protein delta 3) body (exon_1), 3kbp downstream of TSS; GJD3-AS1 body (intron_1), 2kbp downstream of TSS. Process: AV node cell to bundle of His cell communication by electrical coupling, negative regulation of cardiac conduction, monoatomic ion transmembrane transport, gap junction assembly. Function: gap junction channel activity, gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling, monoatomic ion channel activity, protein binding. Component: cell surface, connexin complex, gap junction, plasma membrane. Beta: 0.99. | cg23023126 (chr19:308808, -, CpG Island). In MIER2 (MIER family member 2) body (exon_11), 36kbp downstream of TSS. Process: chromatin remodeling, negative regulation of transcription by RNA polymerase II. Function: histone deacetylase activity, histone deacetylase binding, protein binding, transcription corepressor activity. Component: cytoplasm, nucleoplasm, nucleus, protein-containing complex. Beta: 0.99. | cg25732961 (chr17:7852559, +, S_Shore 293bp). In KDM6B (lysine demethylase 6B) body (exon_21), 18kbp downstream of TSS. Process: positive regulation of transcription by RNA polymerase II, inflammatory response to antigenic stimulus, cardiac muscle cell differentiation, regulation of gene expression. Function: RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone H3K27me2/H3K27me3 demethylase activity, oxidoreductase activity, beta-catenin binding. Component: MLL3/4 complex, nucleoplasm, nucleus. Beta: 0.99. | cg26301689 (chr3:142962862, -, CpG Island). In PAQR9 (progestin and adipoQ receptor family member 9) body (exon_1), 1kbp downstream of TSS; PAQR9-AS1 body, 2kbp downstream of TSS. Function: lipid binding, signaling receptor activity, steroid binding. Component: membrane, plasma membrane. Beta: 0.99. | cg27437510 (chr7:151120110, +, CpG Island). In AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3) body (exon_8), 34kbp downstream of TSS. Process: cellular response to reactive oxygen species, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of postsynaptic membrane neurotransmitter receptor levels. Function: polyubiquitin modification-dependent protein binding, GTPase activator activity, nucleotide binding, metal ion binding. Component: glutamatergic synapse, postsynaptic density, cell periphery, cytoplasm. Beta: 0.99. | cg00077898 (chr6:1080909, +, OpenSea). In ENSG00000176515 body (intron_1), 980bp downstream of TSS; LINC01622 body (intron_1), 21kbp downstream of TSS. Beta: 0.98. | cg00373376 (chr7:2091034, -, OpenSea). In MAD1L1 (mitotic arrest deficient 1 like 1) body (intron_11), 142kbp downstream of TSS; ENSG00000286192 body (intron_16), 151kbp downstream of TSS. Process: positive regulation of mitotic cell cycle spindle assembly checkpoint, attachment of mitotic spindle microtubules to kinetochore, regulation of metaphase plate congression, cell division. Function: kinetochore binding, protein binding. Component: mitotic spindle assembly checkpoint MAD1-MAD2 complex, nuclear pore nuclear basket, nuclear envelope, nuclear membrane. Beta: 0.98. | cg00678709 (chr3:14543238, +, OpenSea). In GRIP2 (glutamate receptor interacting protein 2) body, 13kbp downstream of TSS. Process: neurotransmitter receptor transport, endosome to postsynaptic membrane. Function: protein binding. Component: glutamatergic synapse, plasma membrane, cytoplasm, cytosol. Beta: 0.98. | cg00910503 (chr17:82435790, -, CpG Island). In HEXD (hexosaminidase D) body (exon_6), 17kbp downstream of TSS. Process: carbohydrate metabolic process. Function: hydrolase activity, hydrolyzing O-glycosyl compounds, hydrolase activity, acting on glycosyl bonds, beta-N-acetylhexosaminidase activity, hexosaminidase activity. Component: cytoplasm, extracellular vesicle, nucleus. Beta: 0.98. | cg01305596 (chr16:16134442, +, OpenSea). In ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group)) body (exon_28), 185kbp downstream of TSS. Process: xenobiotic transport across blood-brain barrier, positive regulation of inflammatory response, carboxylic acid transmembrane transport, cellular response to oxidative stress. Function: ATPase-coupled lipid transmembrane transporter activity, ABC-type glutathione S-conjugate transporter activity, ATP hydrolysis activity, hydrolase activity. Component: basolateral plasma membrane, extracellular exosome, cell junction, lateral plasma membrane. Beta: 0.98. | cg02071579 (chr16:88484042, -, N_Shelf 3905bp). In ZFPM1 (zinc finger protein, FOG family member 1) body (intron_1), 31kbp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, positive regulation of macromolecule biosynthetic process, anatomical structure formation involved in morphogenesis, negative regulation of multicellular organismal process. Function: RNA polymerase II-specific DNA-binding transcription factor binding, transcription corepressor activity, metal ion binding, protein binding. Component: transcription regulator complex, nucleoplasm, chromatin, nucleus. Beta: 0.98. | cg02249577 (chr10:50675018, -, CpG Island). In ENSG00000303532 body, 2kbp downstream of TSS; SGMS1-AS1 body (intron_2), 52kbp downstream of TSS. Beta: 0.98. | cg02371401 (chr5:676669, -, N_Shore 1030bp). In TPPP (tubulin polymerization promoting protein) body (intron_2), 17kbp downstream of TSS. Process: positive regulation of protein-containing complex assembly, microtubule nucleation by microtubule organizing center, regulation of microtubule cytoskeleton organization, negative regulation of tubulin deacetylation. Function: protein homodimerization activity, magnesium ion binding, microtubule binding, hydrolase activity. Component: perinuclear region of cytoplasm, microtubule organizing center, postsynaptic Golgi apparatus, microtubule bundle. Beta: 0.98. | cg02515033 (chr7:2165648, +, OpenSea). In MAD1L1 body (intron_10), 68kbp downstream of TSS; ENSG00000286192 body (intron_15), 77kbp downstream of TSS. Beta: 0.98. | cg02723533 (chr11:69654223, -, CpG Island). In CCND1 body (exon_5), 13kbp downstream of TSS; LTO1 (LTO1 maturation factor of ABCE1) body, 21kbp downstream of TSS. Process: protein maturation, ribosomal large subunit biogenesis, telomere maintenance, translational initiation. Function: protein binding. Component: nucleus. Beta: 0.98. | cg03136712 (chr5:140673483, +, CpG Island). In DND1 (DND microRNA-mediated repression inhibitor 1) body (intron_1), 93bp downstream of TSS; WDR55 (WD repeat domain 55) body, 9kbp downstream of TSS. Process: negative regulation of miRNA-mediated gene silencing, 3'-UTR-mediated mRNA destabilization, germ cell development, mRNA stabilization. Function: nucleic acid binding, mRNA 3'-UTR binding, protein binding, RNA binding. Component: cytoplasm, cytosol, nucleoplasm, nucleus. Process: rRNA processing. Component: cytoplasm, nucleolus, nucleoplasm. Beta: 0.98. | cg03633073 (chr16:89371110, -, OpenSea). In ENSG00000288715 body (intron_1), 47kbp downstream of TSS; ANKRD11 (ankyrin repeat domain 11) body (intron_2), 119kbp downstream of TSS. Process: odontogenesis of dentin-containing tooth, skeletal system morphogenesis, face morphogenesis, head morphogenesis. Component: cytosol, nucleoplasm, nucleus. Beta: 0.98. | cg03729251 (chr4:150579883, +, CpG Island). In LRBA (LPS responsive beige-like anchor protein) body (intron_40), 436kbp downstream of TSS; LRBA-AS1 body (exon_2), 794bp downstream of TSS. Process: mitophagy, protein localization to phagophore assembly site. Function: protein binding, protein kinase binding. Component: endoplasmic reticulum membrane, lysosomal membrane, Golgi apparatus, plasma membrane. Beta: 0.98. | cg03760035 (chr21:31251990, +, CpG Island). In TIAM1 (TIAM Rac1 associated GEF 1) body (exon_5), 308kbp downstream of TSS. Process: positive regulation of epithelial to mesenchymal transition, regulation of small GTPase mediated signal transduction, positive regulation of cell population proliferation, Wnt signaling pathway, planar cell polarity pathway. Function: guanyl-nucleotide exchange factor activity, kinase binding, lipid binding, protein binding. Component: cell-cell contact zone, anchoring junction, cell-cell junction, plasma membrane. Beta: 0.98. | cg03991547 (chr13:112160805, -, N_Shelf 2698bp). In ENSG00000304701 promoter, 908bp upstream of TSS; ENSG00000304677 body (intron_1), 3kbp downstream of TSS. Beta: 0.98. | cg04027043 (chr11:8357244, +, OpenSea). Intergenic. Beta: 0.98. | cg04254198 (chr17:79706040, +, OpenSea). In LINC02078 promoter, 1kbp upstream of TSS; ENSG00000306583 body (intron_1), 27kbp downstream of TSS. Beta: 0.98. | cg04411052 (chr14:71752344, -, OpenSea). In ENSG00000302484 promoter, 461bp upstream of TSS. Beta: 0.98. | cg04511195 (chr19:3523011, +, OpenSea). In FZR1 (fizzy and cell division cycle 20 related 1) body (exon_2), 17kbp downstream of TSS. Process: positive regulation of anaphase-promoting complex-dependent catabolic process, positive regulation of ubiquitin protein ligase activity, positive regulation of cell population proliferation, mitotic G2 DNA damage checkpoint signaling. Function: ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activator activity, ubiquitin ligase activator activity, anaphase-promoting complex binding. Component: anaphase-promoting complex, nuclear membrane, nucleoplasm, cytoplasm. Beta: 0.98. | cg04904318 (chr17:48530466, -, CpG Island). In HOXB1 (homeobox B1) body (exon_1), 545bp downstream of TSS; ENSG00000294508 body (intron_2), 3kbp downstream of TSS. Process: pattern specification process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II. Function: RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, protein domain specific binding. Component: chromatin, nucleoplasm, nucleus. Beta: 0.98. | cg04927341 (chr1:86110814, +, OpenSea). In COL24A1 (collagen type XXIV alpha 1 chain) body (intron_5), 46kbp downstream of TSS. Process: extracellular matrix organization. Function: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, protein binding. Component: basement membrane, endoplasmic reticulum lumen, extracellular matrix, extracellular region. Beta: 0.98. | cg05218653 (chr16:2284963, -, S_Shore 617bp). In ABCA3 body (exon_24), 56kbp downstream of TSS. Beta: 0.98. | cg05804170 (chr1:3204950, +, OpenSea). In PRDM16 (PR/SET domain 16) body (intron_2), 136kbp downstream of TSS; ENSG00000279839 promoter, 1kbp upstream of TSS. Process: negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of white fat cell differentiation, tolerance induction in gut-associated lymphoid tissue. Function: DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone H3K9 monomethyltransferase activity, DNA-binding transcription factor activity. Component: transcription repressor complex, nuclear body, nucleoplasm, chromosome. Beta: 0.98. | cg05928290 (chr14:53952010, -, CpG Island). In BMP4 (bone morphogenetic protein 4) body (exon_3), 7kbp downstream of TSS. Process: positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis, negative regulation of mesenchymal cell proliferation involved in ureter development, blood vessel endothelial cell proliferation involved in sprouting angiogenesis, negative regulation of vascular associated smooth muscle cell migration. Function: chemoattractant activity, growth factor activity, BMP receptor binding, co-receptor binding. Component: endoplasmic reticulum lumen, extracellular region, extracellular space. Beta: 0.98. | cg05982473 (chr11:3166573, -, S_Shore 1035bp). In OSBPL5 (oxysterol binding protein like 5) body, 166bp downstream of TSS. Process: phosphatidylserine acyl-chain remodeling, intermembrane phospholipid transfer, Golgi to plasma membrane transport, cholesterol metabolic process. Function: phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity, phosphatidylinositol-4-phosphate binding, phosphatidylserine transfer activity, phospholipid transporter activity. Component: endoplasmic reticulum-plasma membrane contact site, transporter complex, cytosol, endoplasmic reticulum membrane. Beta: 0.98. | cg06127256 (chr16:73172689, +, OpenSea). In ZFHX3 (zinc finger homeobox 3) body, 719kbp downstream of TSS. Process: negative regulation of transcription by RNA polymerase II, positive regulation of myoblast differentiation, response to transforming growth factor beta, circadian regulation of gene expression. Function: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, nucleic acid binding. Component: transcription regulator complex, nuclear body, nucleoplasm, chromatin. Beta: 0.98. | cg06236737 (chr16:89883811, +, S_Shelf 3896bp). In TCF25 (TCF25 ribosome quality control complex subunit) body (intron_2), 10kbp downstream of TSS. Process: regulation of protein K48-linked ubiquitination, rescue of stalled cytosolic ribosome, ribosome-associated ubiquitin-dependent protein catabolic process. Function: protein binding. Component: RQC complex, cytosol, nucleus. Beta: 0.98. | cg06554744 (chr17:18247821, -, CpG Island). In FLII (FLII actin remodeling protein) body (exon_20), 11kbp downstream of TSS. Process: actin polymerization or depolymerization, barbed-end actin filament capping, sarcomere organization, myofibril assembly. Function: actin binding, actin filament binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding. Component: actin cytoskeleton, focal adhesion, brush border, centrosome. Beta: 0.98. | cg06565975 (chr8:142742499, -, S_Shelf 2607bp). In SLURP1 (secreted LY6/PLAUR domain containing 1) promoter, 93bp upstream of TSS; ENSG00000253196 body (intron_1), 4kbp downstream of TSS. Process: negative regulation of cell population proliferation, urokinase plasminogen activator signaling pathway, cell activation, cell adhesion. Function: acetylcholine receptor activator activity, cytokine activity, protein binding. Component: extracellular exosome, extracellular region, extracellular space. Beta: 0.98. | cg06566039 (chr6:22569556, +, CpG Island). In HDGFL1 (HDGF like 1) promoter, 10bp upstream of TSS; CASC15 body, 905kbp downstream of TSS. Process: chromatin remodeling. Component: nucleus. Beta: 0.98. | cg06807993 (chr17:81125985, -, N_Shelf 2964bp). In AATK (apoptosis associated tyrosine kinase) body (intron_7), 40kbp downstream of TSS; MIR338 promoter, 36bp upstream of TSS. Process: brain development, neuron apoptotic process. Function: protein serine/threonine kinase activity, transferase activity, nucleotide binding, protein binding. Component: cytoplasm, endomembrane system, membrane, perinuclear region of cytoplasm. Beta: 0.98. | cg06933816 (chr16:70664243, -, CpG Island). In MTSS2 (MTSS I-BAR domain containing 2) body (exon_15), 22kbp downstream of TSS; ENSG00000279569 body, 3kbp downstream of TSS. Process: cellular response to platelet-derived growth factor stimulus, activation of GTPase activity, plasma membrane organization, cell projection assembly. Function: phosphatidylinositol-4,5-bisphosphate binding, GTPase activator activity, actin monomer binding, phospholipid binding. Component: cortical actin cytoskeleton, plasma membrane, ruffle membrane, focal adhesion. Beta: 0.98. | cg07690734 (chr10:132375157, -, OpenSea). In LRRC27 (leucine rich repeat containing 27) body (exon_11), 43kbp downstream of TSS. Function: protein binding. Beta: 0.98. | cg08076462 (chr16:87750704, +, OpenSea). In KLHDC4 (kelch domain containing 4) body (intron_4), 15kbp downstream of TSS. Function: protein binding. Beta: 0.98. | cg08389497 (chr10:72060733, +, OpenSea). In SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2) body (exon_11), 28kbp downstream of TSS. Process: regulation of cell-substrate adhesion, positive regulation of cell motility, extracellular matrix organization, synapse assembly. Function: metalloendopeptidase inhibitor activity, extracellular matrix binding, glycosaminoglycan binding, calcium ion binding. Component: extracellular matrix, extracellular space, gel phase of interstitial matrix. Beta: 0.98. | cg08786136 (chr16:88992207, -, OpenSea). In ENSG00000259989 body (exon_2), 29kbp downstream of TSS. Beta: 0.98. | cg08971334 (chr5:769980, +, OpenSea). In ZDHHC11B (zDHHC palmitoyltransferase 11B (putative)) body (intron_1), 15kbp downstream of TSS; BRD9P2 promoter, 1kbp upstream of TSS. Process: antiviral innate immune response, protein targeting to membrane. Function: acyltransferase activity, palmitoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, transferase activity. Component: Golgi apparatus, endoplasmic reticulum, membrane. Beta: 0.98. | cg09053902 (chr16:3984297, -, OpenSea). In ADCY9 (adenylate cyclase 9) body (intron_6), 132kbp downstream of TSS. Process: adenylate cyclase-activating G protein-coupled receptor signaling pathway, vascular endothelial cell response to laminar fluid shear stress, cellular response to glucagon stimulus, cyclic nucleotide biosynthetic process. Function: phosphorus-oxygen lyase activity, adenylate cyclase activity, nucleotide binding, metal ion binding. Component: axon, dendrite, membrane, plasma membrane. Beta: 0.98. | cg09115646 (chr10:2936495, -, OpenSea). In ENSG00000295558 promoter, 1kbp upstream of TSS. Beta: 0.98. | cg09178970 (chr12:122867251, +, CpG Island). In VPS37B (VPS37B subunit of ESCRT-I) body (exon_4), 29kbp downstream of TSS. Process: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, positive regulation of viral budding via host ESCRT complex, protein targeting to membrane, viral release from host cell. Function: calcium-dependent protein binding, protein binding. Component: late endosome membrane, extracellular exosome, ESCRT I complex, plasma membrane. Beta: 0.98. | cg09655876 (chr6:161140034, -, OpenSea). In AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4) body (intron_7), 134kbp downstream of TSS. Process: CDP-diacylglycerol biosynthetic process, phospholipid metabolic process, phosphatidic acid biosynthetic process, phospholipid biosynthetic process. Function: 1-acylglycerol-3-phosphate O-acyltransferase activity, lysophosphatidic acid acyltransferase activity, transferase activity, protein binding. Component: endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, mitochondrial outer membrane. Beta: 0.98. | cg09848445 (chr10:43106414, -, S_Shore 697bp). In RET (ret proto-oncogene) body (exon_5), 29kbp downstream of TSS. Process: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, glial cell-derived neurotrophic factor receptor signaling pathway, cell surface receptor protein tyrosine kinase signaling pathway. Function: transmembrane receptor protein tyrosine kinase activity, transferase activity, calcium ion binding, nucleotide binding. Component: plasma membrane protein complex, endosome membrane, receptor complex, axon. Beta: 0.98. | cg09888620 (chr22:39649699, -, CpG Island). In CACNA1I (calcium voltage-gated channel subunit alpha1 I) body (exon_10), 79kbp downstream of TSS. Process: calcium ion import across plasma membrane, monoatomic ion transmembrane transport, signal transduction, calcium ion transmembrane transport. Function: high voltage-gated calcium channel activity, monoatomic ion channel activity, protein binding, voltage-gated calcium channel activity. Component: membrane, monoatomic ion channel complex, plasma membrane, voltage-gated calcium channel complex. Beta: 0.98. | cg09974041 (chr8:10416380, +, OpenSea). In MSRA (methionine sulfoxide reductase A) body (intron_5), 362kbp downstream of TSS. Process: cellular response to oxidative stress, methionine metabolic process, protein modification process, protein repair. Function: L-methionine (S)-S-oxide reductase activity, oxidoreductase activity, peptide-methionine (S)-S-oxide reductase activity, protein binding. Component: extracellular exosome, mitochondrial matrix, mitochondrion, nucleoplasm. Beta: 0.98. | cg10107671 (chr19:647289, -, CpG Island). Intergenic. Beta: 0.98. | cg10150962 (chr16:86370773, -, OpenSea). Intergenic. Beta: 0.98. | cg10316525 (chr15:40279936, +, CpG Island). In ANKRD63 (ankyrin repeat domain 63) body (exon_1), 3kbp downstream of TSS; PLCB2 (phospholipase C beta 2) body, 28kbp downstream of TSS. Process: detection of chemical stimulus involved in sensory perception of bitter taste, phospholipase C-activating G protein-coupled receptor signaling pathway, release of sequestered calcium ion into cytosol, phosphatidylinositol-mediated signaling. Function: phosphatidylinositol-4,5-bisphosphate phospholipase C activity, G-protein beta/gamma-subunit complex binding, phosphoric diester hydrolase activity, C-type glycerophospholipase activity. Component: G-protein beta/gamma-subunit complex, cytoplasm, cytosol, neuronal dense core vesicle. Beta: 0.98. | cg11120115 (chr7:99052238, -, OpenSea). In SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) body (exon_7), 92kbp downstream of TSS. Process: negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of ubiquitin-dependent protein catabolic process, Wnt signaling pathway, planar cell polarity pathway, protein targeting to vacuole involved in autophagy. Function: transforming growth factor beta receptor binding, ubiquitin-protein transferase activity, ubiquitin protein ligase activity, phospholipid binding. Component: extracellular exosome, neuronal cell body, plasma membrane, mitochondrion. Beta: 0.98. | cg11218175 (chr11:495084, -, CpG Island). In RNH1 (ribonuclease/angiogenin inhibitor 1) body (intron_9), 12kbp downstream of TSS. Process: regulation of Arp2/3 complex-mediated actin nucleation, mRNA catabolic process, tRNA stabilization, cell migration. Function: protein binding, ribonuclease inhibitor activity. Component: angiogenin-PRI complex, extracellular exosome, plasma membrane, lamellipodium. Beta: 0.98. | cg11408395 (chr15:101045506, -, OpenSea). In LRRK1 (leucine rich repeat kinase 1) body (intron_20), 126kbp downstream of TSS; LRRK1-AS1 body, 41kbp downstream of TSS. Process: positive regulation of canonical Wnt signaling pathway, positive regulation of signal transduction. Function: protein serine/threonine kinase activity, identical protein binding, transferase activity, nucleotide binding. Component: cytoplasm, cytosol, plasma membrane. Beta: 0.98. | cg11410726 (chr11:69810641, +, CpG Island). In FGF3 (fibroblast growth factor 3) body (exon_3), 9kbp downstream of TSS. Process: negative regulation of cardiac muscle tissue development, positive regulation of cell population proliferation, fibroblast growth factor receptor signaling pathway, regulation of multicellular organismal process. Function: fibroblast growth factor receptor binding, growth factor activity, protein binding. Component: cytoplasm, extracellular region, extracellular space. Beta: 0.98. | cg11449408 (chr17:82898181, -, N_Shore 818bp). In TBCD (tubulin folding cofactor D) body (intron_17), 146kbp downstream of TSS. Process: cell morphogenesis involved in neuron differentiation, negative regulation of microtubule polymerization, post-chaperonin tubulin folding pathway, microtubule cytoskeleton organization. Function: GTPase activator activity, beta-tubulin binding, protein binding, protein-folding chaperone binding. Component: bicellular tight junction, lateral plasma membrane, adherens junction, microtubule. Beta: 0.98. | cg11617144 (chr8:144504389, -, N_Shore 619bp). In GPT (glutamic--pyruvic transaminase) body (exon_1), 2kbp downstream of TSS; ENSG00000255182 body (intron_2), 1kbp downstream of TSS. Process: L-alanine catabolic process. Function: L-alanine:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding, transaminase activity, transferase activity. Component: cytoplasm, cytosol, extracellular exosome, extracellular space. Beta: 0.98. | cg11710211 (chr19:56097695, -, CpG Island). In ZNF787 (zinc finger protein 787) body (intron_2), 24kbp downstream of TSS. Process: regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific double-stranded DNA binding, metal ion binding, sequence-specific DNA binding. Component: nucleus. Beta: 0.98. | cg11908202 (chr17:43378979, -, CpG Island). In LINC00910 body (intron_3), 10kbp downstream of TSS. Beta: 0.98. | cg12205822 (chr12:2504775, -, OpenSea). In CACNA1C body (intron_7), 534kbp downstream of TSS. Beta: 0.98. | cg12216054 (chr6:33456436, +, S_Shore 1683bp). In ZBTB9 (zinc finger and BTB domain containing 9) body (exon_2), 2kbp downstream of TSS. Process: regulation of transcription by RNA polymerase II. Function: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding. Component: nucleus. Beta: 0.98. | cg12888113 (chr1:11046991, -, OpenSea). In MASP2 (MBL associated serine protease 2) body (exon_2), 250bp downstream of TSS. Process: cell surface pattern recognition receptor signaling pathway, complement activation, classical pathway, positive regulation of opsonization, innate immune response. Function: serine-type endopeptidase activity, calcium-dependent protein binding, complement component C4b binding, calcium ion binding. Component: external side of plasma membrane, extracellular exosome, symbiont cell surface, extracellular region. Beta: 0.98. | cg13008301 (chr20:56403693, +, CpG Island). In CSTF1 (cleavage stimulation factor subunit 1) body (exon_6), 11kbp downstream of TSS. Process: mRNA 3'-end processing, mRNA processing, regulation of mRNA 3'-end processing. Function: RNA binding, protein binding. Component: mRNA cleavage stimulating factor complex, nucleoplasm, nucleus. Beta: 0.98. | cg13244241 (chr10:100731974, -, S_Shore 720bp). In ENSG00000295664 promoter, 636bp upstream of TSS; ENSG00000295641 body (exon_3), 3kbp downstream of TSS. Beta: 0.98. | cg13244315 (chr1:1050013, -, S_Shore 964bp). In AGRN (agrin) body (exon_27), 30kbp downstream of TSS. Process: positive regulation of synaptic assembly at neuromuscular junction, G protein-coupled acetylcholine receptor signaling pathway, positive regulation of transcription by RNA polymerase II, clustering of voltage-gated sodium channels. Function: transmembrane receptor protein tyrosine kinase activator activity, extracellular matrix structural constituent, acetylcholine receptor regulator activity, structural constituent of cytoskeleton. Component: gel phase of basement membrane, extracellular exosome, extracellular matrix, extracellular region. Beta: 0.98. | cg13476777 (chr9:137017232, +, CpG Island). In ABCA2 (ATP binding cassette subfamily A member 2) body (exon_18), 12kbp downstream of TSS. Process: negative regulation of receptor-mediated endocytosis involved in cholesterol transport, positive regulation of low-density lipoprotein particle receptor catabolic process, positive regulation of amyloid precursor protein biosynthetic process, regulation of protein localization to cell periphery. Function: ATPase-coupled transmembrane transporter activity, endopeptidase regulator activity, ceramide floppase activity, ATP hydrolysis activity. Component: ATP-binding cassette (ABC) transporter complex, intracellular membrane-bounded organelle, microtubule organizing center, cytoplasmic vesicle. Beta: 0.98. | cg13909661 (chr12:26233900, -, OpenSea). In SSPN (sarcospan) body (exon_3), 112kbp downstream of TSS; ENSG00000255750 body (intron_1), 86kbp downstream of TSS. Process: camera-type eye development, cell adhesion, muscle contraction. Component: dystrophin-associated glycoprotein complex, neuromuscular junction, postsynaptic membrane, transport vesicle. Beta: 0.98. | cg14242024 (chr9:136075002, +, CpG Island). In NACC2 (NACC family member 2) body (intron_1), 20kbp downstream of TSS. Process: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of transcription by RNA polymerase II, negative regulation of cell population proliferation, protein-containing complex localization. Function: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein-containing complex binding, protein homodimerization activity. Component: chromatin, nuclear lumen, nucleus. Beta: 0.98. | cg14285937 (chr1:8338675, +, S_Shelf 3100bp). In SLC45A1 (solute carrier family 45 member 1) body (intron_7), 21kbp downstream of TSS. Process: D-glucose transmembrane transport, galactose transmembrane transport, sucrose transport, transmembrane transport. Function: D-glucose:proton symporter activity, transmembrane transporter activity, galactose:proton symporter activity, sucrose:proton symporter activity. Component: membrane. Beta: 0.98. | cg14435720 (chr9:136670635, +, CpG Island). In EGFL7 (EGF like domain multiple 7) body (intron_8), 12kbp downstream of TSS; MIR126 body (exon_1), 33bp downstream of TSS. Process: positive regulation of endothelial cell proliferation, negative regulation of Notch signaling pathway, blood vessel development, cell differentiation. Function: calcium ion binding, protein binding, signaling receptor binding. Component: cell surface, extracellular matrix, extracellular region. Beta: 0.98.", | |
| "answer": "31", | |
| "ground_truth_note": "True age: 31 years (GSM1506465_GSE61496, GSE61496)." | |
| }, | |
| { | |
| "pool": "gtex_age_pairwise", | |
| "display_name": "GTEx Age / Pairwise", | |
| "domain": "transcriptomics", | |
| "lb_code": "LB-0018", | |
| "prompt": "Which of the following two Muscle samples comes from an older individual?\n\nOptions: A. Sample A B. Sample B\n\nSample a: Demographic information: male\nExpression data:\nTop-2773 expressed genes: TTN; SOD2; ND4; COX1; ND1; CKM; ND2; DES; ACTA1; ATP6; NEB; CYTB; GAPDH; PDK4; MYBPC1; CMYA5; COX3; COX2; TTN-AS1; MYH1; ALDOA; TPM2; GLUL; ND5; TPT1; MB; YBX3; KLHL41; FLNC; PYGM; ATP8; ENO3; FHL1; NFE2L1; UBC; TNNC2; TNNT3; NDRG2; MYBPC2; EEF2; RYR1; CSDE1; ATP2A1; ND4L; TPM1; MYL1; EEF1A2; SYNPO2; NRAP; MKNK2; OBSCN; ND6; MAP4; FKBP5; XIRP2; PDE4DIP; SVIL; AHNAK; FBXO32; PDLIM3; NEAT1; TXNIP; MYH2; ND3; ACTN2; SYNPO; BIN1; TNNI2; ZNF106; DDN; HSPB8; SPTB; ACACB; SYNM; KIF1C; ATP2A2; COQ8A; LDHA; GSN; TRDN; EIF4G1; GPX3; HSPB7; ZAK; SLC38A1; CHMP1B; TRIM63; HSP90AB1; ZFAND5; PFKM; KIAA0368; PLEC; PSAP; SQSTM1; KTN1; EGLN1; ADPRHL1; OPTN; GNAS; EIF1; HSPB1; IGFN1; NACA; ACSL1; STAC3; RHOB; TSC22D3; SORBS1; CTSD; TCAP; PKM; MYOM2; SRRM2; BCL6; H19; RPLP1; KIF1B; FHL3; RPL4; MYOZ1; FEM1A; MAT2A; MYO18A; HSPA8; MALAT1; ALPK3; RPLP0; NEXN; MYLPF; DCAF6; MYH7; ATP1A1; CRYAB; EIF4G2; PGM1; PDLIM5; C6orf106; PTP4A2; STAT3; MLXIP; CLIP1; SPEG; DIAPH1; ACTB; HSPB6; HDLBP; OAZ1; NFIC; ATP5B; NRDC; PTP4A1; PNRC1; RPL13; RGMA; APOD; MYOM1; PRDX6; MBNL1; PPP1CB; CAST; FTH1; EEF1G; RAD23A; LPIN1; YWHAE; MT1X; NAP1L1; ACADVL; SORT1; VCL; RPL8; PLEKHG3; PABPC4; PCBP1; RACK1; ATP1A2; CLIC5; PCNT; STK40; ATP5A1; CASQ1; RPS6; YBX1; TNS1; RNF10; HADHA; HK1; ATF4; AKR1C2; CTSB; EIF4A2; RPL10; BAG3; ACO2; C5orf45; GABARAPL1; MT2A; JPH1; IDH2; GYG1; HSP90AA1; CNBP; KLHL21; HECTD1; H1F0; USO1; C1orf21; PSMD2; KLHL40; SLC25A3; TNNT1; SLN; IPO7; SUN2; RXRA; BEST1; HNRNPA2B1; EIF3A; RPS8; DHRS7; PGK1; AMOTL1; EIF4B; EHBP1L1; YWHAG; FTL; PSME4; MBNL1-AS1; PHC2; PINK1; IMPA2; SRL; SLC25A4; PFKFB3; FAM134B; GOLGA4; NAMPT; VCP; RPL19; UGP2; TUBA4A; DYNC1H1; USP13; PPP1R27; FLII; UBR4; RPL13AP5; MDH2; DST; FXR1; CFLAR; RAF1; NPLOC4; CALM1; HADHB; TMOD1; SLC7A2; MATR3; TBC1D4; ACTN3; CDV3; IGFBP5; TLN1; NCL; NR4A1; PPM1B; RPL13A; HSPA9; CORO6; UACA; SELENOW; GLRX; DDX3X; SLC43A2; FOSL2; RPS3; SH3GLB1; PER1; RPL37A; RPL5; QKI; DDX17; DCN; SLC38A2; MYL2; EEF1A1; PHKA1; SERPINA3; PLIN4; SLC7A6; MAP7D1; SETD7; TPM3; CFL2; RERE; NCKAP1; NPEPPS; RPS4X; UCP3; MYOT; RPL32; HNRNPU; RPL15; SCN1B; EIF4EBP2; PRPF8; CAPN3; RPS2; PRKAR1A; VDAC1; AFF1; SPARCL1; AES; SMG1; JAK1; CLTCL1; RPS24; ANKRD39; MYO18B; RPS23; CRIM1; PCBP1-AS1; CST3; RAB7A; HUWE1; ANKRD23; MAST2; WNK1; OGDH; MAPKAPK2; ADCY9; IPO5; RAPGEF1; B2M; RPS11; TACC2; RPS18; CANX; PPP1R12B; USP24; P4HB; RBM24; ADD1; TNKS1BP1; RHOA; COBL; USP47; MYH14; HFE2; CS; UBR3; TMBIM6; TIMP3; CAP2; SMTNL2; ZCCHC24; BAG6; ACTG1; BTG2; PTPN11; RIF1; KPNB1; CHAC1; UBE2D3; KPNA1; BHLHE40; GPI; PINK1-AS; ANXA11; ATG9A; DYSF; ZRANB1; ITGA7; ICMT; GHITM; KLF10; BTBD1; AMFR; PSMD8; NFIL3; CD63; HNRNPDL; SERBP1; AK1; SCN4A; NGRN; RPL30; KPNA4; PRDX1; MLIP; VIM; RASD1; CD99L2; ABRA; NDUFS2; RRAD; ATP1B1; PLEKHM2; PLIN2; SLC16A3\n\nSample b: Demographics: male\nTranscriptomic profile:\nTop-2766 expressed genes: TTN; COX1; ND4; CKM; ACTA1; ND1; SOD2; DES; CYTB; ATP6; ND2; COX3; COX2; UBC; NEB; GAPDH; FLNC; ND5; MB; MYH7; TPM2; CMYA5; MYBPC1; TTN-AS1; ALDOA; TPT1; PDK4; ATP2A2; ATP8; MYH1; RYR1; KLHL41; YBX3; OBSCN; NRAP; TNNT1; FBXO32; MKNK2; EEF2; PYGM; ND6; ND4L; SYNPO2; MYL2; GLUL; ENO3; FKBP5; NFE2L1; FHL1; SVIL; CSDE1; ACSL1; MYH2; ND3; EEF1A2; SYNPO; ACTN2; TPM3; TRIM63; HSPB7; TNNC2; PDE4DIP; COQ8A; ATP1A2; BIN1; KIF1C; TNNT3; PDLIM3; NEAT1; PCNT; MYL1; NDRG2; PSAP; TNNC1; XIRP2; ATP2A1; ALPK3; HSP90AB1; MAP4; ADPRHL1; ACACB; TNS1; CALM1; NACA; SRRM2; HSPA8; EIF4G1; ATP5B; TPM1; AHNAK; TXNIP; ASB2; PLEC; MYBPC2; SQSTM1; MYO18A; PLIN4; SLC38A1; ANKRD39; PFKM; ANKRD23; TCAP; ZNF106; OPTN; TRDN; KIAA0368; CLIP1; SERPINA3; PKM; RPLP1; CORO6; TNNI1; TSC22D3; RPL4; IGFBP5; SPTB; ACADVL; PADI2; BCL6; GSN; SRL; EIF1; MYH6; PGM1; MYOZ1; FTH1; RPLP0; STAC3; HADHB; EEF1G; EGLN1; TNNI2; HSPB6; HADHA; ATP5A1; CTSD; FABP3; MYH14; GNAS; MYLPF; OGDH; SYNM; MT2A; NFIC; CRYAB; MT1X; SLC25A4; USP54; MLXIP; FHL3; FEM1A; HSPB8; HDLBP; CAST; HSPB1; MYO18B; SPEG; RAD23A; LPIN1; RPL13; MAST2; HNRNPA2B1; RERE; BEST1; TMPO; PTP4A2; HECTD1; PABPC4; DCAF6; IDH2; PERM1; KIF1B; ACO2; SLC25A3; VCP; C6orf106; YBX1; HK1; CHMP1B; ATF4; RPL8; PLIN2; PSMD8; EHBP1L1; EIF4G2; RACK1; RPL19; PHC2; RPL10; PCBP1; LOC100507537; EIF4B; CFLAR; VCL; HSPA9; UBB; MYOM2; TRIM54; PSMD2; SLC6A6; NRDC; IL6R; TUBA4A; RGMA; NCL; RNF10; KLHL40; NPLOC4; FLII; C5orf45; BAG3; MYOM3; CKMT2; MDH2; IGFN1; PRKAR1A; PRDX6; DHRS7; EIF3A; ZAK; TGM2; DYNC1H1; MAPKAPK3; KTN1; CYB5R1; RPL13AP5; RPL37A; TLN1; VEGFA; RPS6; UBR4; P4HB; CA3; MYOM1; CD63; HSP90AA1; TACC2; AMOTL1; CNTFR; GYG1; ACTN3; ATP1A1; RXRA; LDHA; CAP2; CNBP; CLUH; IPO7; RAPGEF1; VDAC1; CASQ1; MFN2; SSH2; MAP7D1; MFGE8; RPL13A; YWHAE; PINK1; AES; H19; EIF4A2; RPS3; RRAD; PPTC7; ACTB; PPP1R1A; PRPF8; ABLIM2; TMOD1; RPS4X; FOSL2; RPL5; PPP1CB; DST; YWHAG; RPS24; GLRX; WNK1; SLC2A4; GOLGA4; STK25; MBNL1; AMFR; CS; RAF1; PFKFB3; CAPN3; OAZ1; KIAA1217; SMTNL2; SMG1; LDB3; TMEM38A; IP6K3; RPS11; RASA4B; RPS8; NEDD4; ATP1B1; TOM1; RPL30; HUWE1; IGF2R; GPX3; PLEKHM2; RPS16; PER1; FXR1; VPS4A; MALAT1; RPS18; RPL32; STK40; NCOR2; CANX; PDLIM5; CDV3; ZFAND5; DUSP3; SCN1B; BAG6; MATR3; HDGF; ANXA11; TBX15; SLC7A6; NAP1L1; TRIP10; ARRDC2; PSMD3; PHKA1; BHLHE40; NUMA1; SLC38A2; MLLT6; HDAC4; GHITM; MAPKAPK2; RPLP2; CD59; PSMA7; BLCAP; EIF5A; RASA4; PRKACA; PXN; SNN; PGK1; DDX3X; PKD1; USO1; MYOT; SLC22A5; KLHL21; UQCRC1; UQCRC2; RPS9; ARF1; ATOH8; NCKAP1; RPL15; CD99L2; UBA1; NORAD; STIM1; AKT2; RPS23; DIAPH1; DYSF; SRCAP; ABLIM1; NGRN; TBC1D8; STARD7; ADRM1; DDB1; RPS2; PDLIM1; SLN; IPO5; RAD23B; RPL29; SLC16A3; ESRRA; GPD1; RPL14; MPRIP; TIMP3; GPC1; EIF5; EEF1D; PCBP1-AS1; PLEKHG3; UBR3; ATG9A; MAN2A2; DMPK; KCNJ11; SMYD1; SORT1\n\nPathway enrichment results:\nSample-A shows low activity in Defective Galnt3 Causes Hftc (NES: -0.08, genes: MUC7, MUC5AC, MUCL1, MUC17, MUC21 and 11 other genes), while Sample-B shows very low activity (NES: -0.15, genes: MUC17, MUC7, MUC21, MUC13, MUC6 and 11 other genes). Sample-A shows moderate activity in Initial Triggering Of Complement (NES: 0.11, genes: FCN2, GZMM, CRP, COLEC10, MBL2 and 75 other genes), while Sample-B shows moderately low activity (NES: 0.03, genes: COLEC10, GZMM, COLEC11, CRP, MBL2 and 75 other genes). Sample-A shows moderately low activity in Gaba Synthesis Release Reuptake And Degradation (NES: 0.02, genes: GAD1, SNAP25, GAD2, SLC32A1, SLC6A11 and 14 other genes), while Sample-B shows moderate activity (NES: 0.08, genes: SLC6A13, SLC6A12, GAD2, SLC32A1, SLC6A11 and 14 other genes). Sample-A shows moderately low activity in Acetylcholine Neurotransmitter Release Cycle (NES: 0.05, genes: SYT1, SNAP25, SLC5A7, CHAT, SLC18A3 and 12 other genes), while Sample-B shows moderate activity (NES: 0.10, genes: RIMS1, PPFIA2, CHAT, SLC5A7, SLC18A3 and 12 other genes).", | |
| "answer": "B", | |
| "ground_truth_note": "Sample-A (GTEX-S4Q7-1526-SM-3K2AG): 20-29; Sample-B (GTEX-SNOS-1526-SM-32PLW): 40-49" | |
| }, | |
| { | |
| "pool": "gtex_age_multiclass", | |
| "display_name": "GTEx Age / Multiclass", | |
| "domain": "transcriptomics", | |
| "lb_code": "LB-0014", | |
| "prompt": "Human Skin transcriptomics data (RNA-seq, log1p-transformed TPM). Sex: male.\n\nTranscriptomic profile:\n3935 genes: not detected | 1038 genes (0.69-4.69): FAM159A, LOC102724555, MIR126, MIR203B, MIR25, MIR30C1, MIR4646, MIR5088, MIR6089, MIR638, MIR6511A2, MIR6511A3, MIR6511B2, MIR6769B, MIR6779, MIR6790, MIR6846, MIR6851, MIR10B, MIR125B2, MIR4639, MIR6731, MIR6770-3, MIR6781, MIR6798, MIR6815, RNASE11, SLC17A6, C6orf229, HIST1H2BB, LOC100506082, MIR6766, MIR6862-1, OR6C75, MIR1976, MIR26A2, MIR6776, MIR6799, MIR6853, C14orf105, C6orf10, MACROD2-IT1, MIR3149, MIR4310, MOXD2P, LOC105370404, MIR6780A, MIR6816, ABCC5-AS1, GPR158, LOC100130849, MIR3116-2, MIR4269, MIR7152, SLC6A18, MIR1237, MIR331, MIR3680-1, MIR5094, C21orf62, GUCY2GP, MIR3657, MIR374A, MIR4279, MIR6737, MIR6738, MIR6746, MIR6802, SNORA84, LINC00850, LOC101926941, MIR3116-1, MIR6879, ZNF197-AS1, CSTF3-AS1, LOC105372978, MIR3179-3, MIR6767, PNLIPRP1, RGS21, CYP26A1, MIR3651, MIR5689HG, MIR6833, SNORD116-28, KCNQ5-AS1, MIR132, MIR3155A, LOC102724612, LOC729652, PPP1R2P9, RUVBL1-AS1, ABCC6P2, LOC100505978, MIR23B, MIR3909, RNVU1-3, RTBDN, WFDC11, LINC01499, MIR2909, MIR3135A, MIR3666, MIR6071, SLC4A10, CELF3, MIR3202-2, MIR33B, MIR3202-1, MIR4436B1, MIR6505, MIR6826, FGF16, LINC01583, LOC349160, MIR1343, MIR548S, SNORA11D, ZNF560, KRTAP10-6, LMO7DN, LOC101927653, LOC101929723, LOC101929754, LOC105375875, MIR1233-2, MIR589, MIR6775, SCARNA11, AKAP14, C8orf86, LINC00264, LINC00941, MIR6893, MRGPRX1, SCARNA20, SCHLAP1, BSPH1, CXXC1P1, DNAI2, DSCR10, GAD2, GDF2, GP5, GPR25, ITGAD, LINC00309, LOC100507210, LOC101927156, LOC101929269, LOC101929315, LOC105372672, LOC401312, LOC647323, MAGEB1, MIR4999, MIR643, NOBOX, RLBP1, SALRNA2, SPRY4-IT1, TDRD15, DEFB108B, HCRT, HIST1H2BM, LINC01393, LOC100505817, LOC100505853, LOC105369443, LOC105374293, MIR491, R3HDML, SNORA71D, ASB18, CCDC190, CLSTN2-AS1, CSAG1, CTRB2, FGF19, HOXB13, HP09025, KNCN, LOC100507140, LOC101928696, LOC105372441, LOC642426, MIR1250, MIR1276, MIR3619, MIR4492, OLIG3, SNORD116-24, SNORD116-29, SPOCK3, TSPAN19, GPR139, GPR88, LL22NC01-81G9.3, LOC101060498, LOC101928769, ... (+838 more) | 1044 genes (4.69-5.58): CSNK1G2-AS1, LOC100506319, LOC105373006, MIR650, OLIG2, COL19A1, LINC01031, LOC100505478, LOC101927438, MIR193A, SNORA36B, DEFA3, LOC105373185, OR2W3, PPIAL4F, PRSS42, CRX, MIR6888, PRR23D2, LINC01153, LINC01354, MIR4656, LINC01251, MIR3609, MIR6762, MIR877, SNORD37, TRIM71, ART1, HNF4G, KPNA7, LOC101929662, MIR320C1, CACNG7, LINC00307, LOC101929337, MIR6761, CCDC148-AS1, TNFRSF17, CISTR, CLDN24, LOC400794, MGC27382, DIO2-AS1, MIR1302-3, MIR3133, MIR6735, MIR7851, SIX3, KRTAP12-1, LINC00996, LINC01498, LOC101927418, MIR1229, MIR6856, PRSS2, SNORD17, FTHL17, GNG8, LOC105370802, LOC93463, MIR3128, SPINK8, WFDC13, LOC101928851, MIR135A1, MIR4669, MTRNR2L7, C10orf120, DPYSL5, LINC00684, MIR6795, CNR2, GAGE12I, LOC101929586, OR10H2, CTD-2270F17.1, LOC105373831, MIR3184, SNORA36A, CRYBA1, CXorf65, LOC105376064, LOC440084, SCRT1, LINC00466, LOC100996385, MIR4519, SNORA11E, TMEM52B, LOC100506688, MIR4489, MIR553, SMIM2-IT1, LINC01344, LOC101928596, LOC105374250, SPIB, ADCYAP1, GJB7, LINC00113, LOC151121, PRKCG, TMED11P, FEV, SNORD91B, MIR103B2, MIR153-1, SPINK14, STH, SYP-AS1, TMPRSS11BNL, HLTF-AS1, MIR8069-1, AMER2, SNORD63, VAV3-AS1, ANKRD62, LOC105376171, LOC100131315, LOC101927523, LOC101929901, MIR27A, OR1Q1, OR6B2, LIN28B-AS1, MGAT3-AS1, MIR1231, CCDC63, ACTR3BP2, CACNG6, FLJ38576, LINC00273, LOC388882, LY86-AS1, LOC100996345, LOC102725254, PRR29-AS1, TCP10L2, TMEM235, LOC101928943, MOG, ACTL9, DYTN, LOC101928567, LOC105372343, LOC105373496, MIR4497, DNMT3L, FOXP4-AS1, GABRB1, GABRG2, LOC101929626, LOC105371620, MIR6880, SIGLEC12, TTBK1, DNASE2B, FAM222A-AS1, GFRAL, HIST1H2AL, LOC101929159, MIR425, MIR6765, MIR6774, USP29, DGKK, TPTE2, CALHM1, LINC01494, LOC106699570, PRSS33, ANP32D, ATP6V0D2, CXorf49B, KIR2DL1, LILRA5, OR2A25, RTP1, GAGE10, MIR1302-8, MIR6763, PLCE1-AS1, USP17L2, ARL14, CASC20, ENKUR, FAM133A, FIGLA, GRXCR2, LOC101928580, LOC285696, MIR192, MYOD1, OR52D1, RPSAP52, TAT-AS1, ARHGAP36, AVPR1B, CYP2B6, ... (+844 more) | 1033 genes (5.58-6.41): PHOX2A, ARHGAP31-AS1, CYP3A43, MIR3926-1, NPHS1, C1orf105, FOXD4L4, HCG20, TCF4-AS1, TMEM150B, BTBD18, NKX2-3, DNAJB13, LOC343052, PLSCR5, RGS7, LOC146795, ACY3, CCDC60, ZBTB20-AS4, C7orf34, LINC01474, LOC340512, SMIM2, SMIM6, CCDC172, LOC101929241, PLSCR2, SH2D6, MIR3650, ELSPBP1, MIR5581, RFPL1, SLC18A1, FALEC, HTR3B, CRB1, EFNA2, LEP, MIR10A, PCDH15, RAB40AL, CTD-3080P12.3, GAB4, PAGE3, KRTAP9-6, LOC100128164, LOC102723766, LOC102724050, ZBTB20-AS1, LOC101927131, MAGEC3, TEX26-AS1, SLC12A3, EIF1AX-AS1, LINC00877, LOC643201, PRSS48, LOC100133985, GPR85, DKFZP434L187, PHOX2B, FOXG1, FUT6, LINC01186, HIST1H2AJ, LINC01546, SMC2-AS1, ABCD2, CEACAM8, LOC285593, RNF17, SNORD11, SNORA19, TUBB8, CDH18, LOC100132077, PVALB, RASGRF2-AS1, LY6H, MYH8, CXorf49, IL9R, LINC01267, LOC102724719, LRRC74B, MIR3941, OVOL3, CHST13, IQCA1L, KCNQ5-IT1, LINC00441, LINC01482, LINC01613, LOC102723373, LOC338963, MGAM2, MIR4768, OIT3, PADI4, PAGE4, PLET1, SMCO3, TXNDC2, ABCB5, BSND, CD3G, DPP10-AS1, FCGR1A, FCGR1CP, HFM1, KIAA0087, LOC284632, LOC285389, LURAP1L-AS1, NBPF4, NCR3, NLRP14, POT1-AS1, SCGB2A1, SNCB, ST8SIA6-AS1, UNC13A, WFDC12, XKR7, A1CF, AMZ1, ASB15, AXDND1, BVES-AS1, C8A, CCL4L2, CD5L, CLEC9A, DISP3, DYDC1, FABP2, FAM221B, FTMT, GRID1-AS1, GS1-594A7.3, HAMP, HIGD2B, HIST1H2BI, HIST1H3A, ICAM4, IL17C, KCNJ6, KLF14, KLHDC7A, KRTAP12-2, LCE2A, LCE5A, LINC00905, LINC01260, LOC100130111, LOC101926940, LOC101927285, LOC339059, LOC400002, LOC400997, MROH2B, NTN3, OR10A3, OR13J1, PKN2-AS1, PPP1R17, PWAR1, RNU1-2, RNVU1-18, SCG3, SCN2A, TLR7, TMEM72-AS1, TMEM95, ZIM2-AS1, AICDA, ANKRD45, AQP10, ATOH7, BMP5, C11orf86, CALCA, CCL4, CD300LF, CLEC4E, CPB2, CTB-12O2.1, DBX2, DCSTAMP, DEFA6, DTHD1, ENPP6, FLJ46066, FSTL5, GDF6, GPR65, HHLA2, IFNE, IL12A, ... (+833 more) | 1048 genes (6.41-7.15): ANKRD7, C1orf158, CD180, CXCL3, GVINP1, GZMM, KCNE5, LHCGR, LINC01561, LOC105371919, LOC105373805, OR52N4, PRB4, PRND, SEC14L4, TSPAN16, ART5, ASB11, C17orf105, CD1D, CELF2-AS1, CTSE, FBN3, HSD3B1, KCNV2, LEFTY2, LINC00442, LOC105369364, LRRC3-AS1, SLAMF6, STOML3, CHRNB4, CXorf21, GZMA, KBTBD8, KLRC3, LINC00278, LINC00599, LOC100506178, LOC102724334, LOC105376382, LOC79160, PTTG2, RFX4, RNASE7, TBX21, TM4SF1-AS1, ANKS4B, C1GALT1C1L, C1QL2, CCR5, DCAF12L2, DRGX, LECT1, LINC01549, LOC100128905, LOC105372257, LOC728175, PPEF1, SLC8A3, SPINK7, ALS2CR12, FLJ43879, LOC101927257, SNORD57, HIST2H3C, LOC100240735, CACNA1C-AS2, CYP2A6, DLG1-AS1, GPR20, LOC101929023, SCARNA16, SOX11, GPR52, LOC100505920, NTSR1, ASTN1, IL4, MIR6730, LOC101929798, CHAC1, SLC35F4, TSGA13, PTPRN, LOC101927253, HEPACAM, MIR6759, NFE2, RGR, PRF1, SNORA5C, LOC101929633, HBZ, SMKR1, LINC00365, LOC101928043, LOC101929151, USH2A, GLIPR1L1, IQUB, LOC284865, SYT13, BEND4, LCE2D, BTNL8, CPN2, KLRD1, ZC2HC1B, MKRN3, SCT, TUBA3E, SNORA50C, SLC12A1, SLC36A2, KRT8P41, TTLL6, DEC1, LOC101927787, SNAI3, MIR1302-10, SMCR5, CCDC155, EQTN, LPAR4, KRTAP9-9, CLDN14, TPTE, KCNMA1-AS1, TAS2R3, GNAT2, KCNIP1, ERI3-IT1, HIST1H3J, INSM1, OTOA, LINC00960, TBX4, ZNF728, C16orf82, SLC28A2, DIO1, OVCH1, CCDC38, GPA33, IL5RA, LOC101929897, TM4SF19-AS1, TTTY10, LOC101929710, SNORD45C, OR5P3, OR2H2, SNORD56, SPEF1, DDX11L16, RMST, MIR4737, NPY6R, RP1, TMEM88B, TREML1, VPS13A-AS1, MIR4477B, MIR503HG, NKX2-1, CACNG1, ENO1-AS1, ENTHD1, ELAVL3, FBP2, MIR4701, TARP, TEKT5, CD70, LHFPL3, LUCAT1, ALK, LOC100506895, C1orf61, LINC00924, LOC101928891, PRO1804, CCDC168, UBE2NL, MEP1A, ASB5, HIST1H2AD, NKX6-1, FPR1, C11orf94, CAMK2N2, DEFA5, LEKR1, LOC100288570, MIR6807, NOG, TMEM236, ZNF98, SNORA65, ... (+848 more) | 1041 genes (7.15-7.84): DDX11-AS1, LOC101927911, SPG20-AS1, LOC100507537, MGC12916, NAV2-AS2, FAM209B, KCND2, LOC100506801, TCF21, LOC100506289, LOXHD1, GUCY2D, LOC105376671, RPPH1, LINC01527, FOXF1, TMEFF2, ATP1A3, ERVFRD-1, FLJ46284, GTSF1, BMPER, DHH, HSPB9, LOC100268168, BCL2A1, TNP1, LRRC4C, PLAC8, NR2E3, SNORD2, PGLYRP2, CDIPT-AS1, GLP1R, LOC101927708, SNORD36B, CYP17A1-AS1, GS1-24F4.2, MIR6819, ZNF114, FAM131B, SHISA3, FMN2, FAM57B, CALB1, PHOSPHO1, OLIG1, KLHL10, CHGA, ANKRD20A2, OPA1-AS1, SCARNA13, VWDE, LINC00923, UNC13C, LLPH-AS1, CPNE6, SPNS3, LOC102724919, APOC1P1, KCNJ9, GCNT7, SULT1C4, FCRL6, KIF25, ZNF730, LINC00961, PLPP4, MIR149, LINC00471, GABRR2, RPGRIP1, COL22A1, KRTAP13-1, SYNPO2L, IGSF21, SPAG4, C3AR1, KRTAP1-1, SNORD6, CNTD2, OCM, MGC32805, HRK, LINC00968, PTGES3L, CTAGE1, MYPN, SLC2A14, PABPC4L, ABHD11-AS1, ARID3C, NKAIN2, PLS3-AS1, ABCA17P, LINC01119, LOC644656, GRP, KCNQ5, PPIAL4G, PRAME, PROK1, SNORD23, AADACL3, CRISP2, KLHL7-AS1, MIR223, P2RY8, POU5F2, VIP, GPR55, LOC105274304, SMIM2-AS1, EFHB, ITPKA, ROS1, KCNG3, KRTAP5-9, MAP2K4P1, SLC38A3, SNORD52, ADORA3, LOC729739, SLC5A8, PAX5, C8orf34-AS1, HGD, TP53TG3, USP41, ADIPOQ-AS1, FLJ33360, CHST8, TEKT2, CCDC110, PFN4, PLCXD2, C22orf31, ZFP69B, KRT37, PRR26, GPR18, TAC3, ACSBG2, GDA, LOC100505716, SPAG6, LINC00222, CDKL2, LOC283887, CGB3, SOX2, PCSK1, SOWAHA, ERICH6-AS1, OXCT2P1, LOC102546294, MYO1A, APOBEC2, KLHL38, LOC105372397, DGAT2L6, CR1, GRM4, SIGLEC16, HPN-AS1, PLD5, CHRDL2, MURC, LINC00939, LOC100287808, LOC100506725, LOC100130331, LOC105369438, MIR6126, LOC400685, MSR1, KLHL40, SIGLEC9, CCDC62, DBET, GADL1, LINC01600, TNFAIP6, CLDN19, CSMD1, TMPRSS11D, FOXC2, RASGRF1, F2RL3, GPBAR1, RCVRN, C1QL4, OGDHL, SNORA41, LOC151475, GOLGA8IP, SYNDIG1, CCDC141, MUC12, ... (+841 more) | 1041 genes (7.84-8.51): RND1, GOLGA8H, TMEM145, DNAH5, SNORD34, TMEM246-AS1, CABP4, FXYD2, LY6G6D, SNORD3B-1, TRIM46, TBXAS1, MYLK2, P2RY6, PTPRO, LOC107985816, FAM87B, FBXW10, FAM228A, RIMS1, PCDHA7, LOC101929541, PCDHA9, HS3ST1, HYDIN, FCRLA, GK3P, ANKLE1, PRSS54, CCDC181, SARDH, LOC648987, CELF5, SV2C, CH25H, LOC101928979, SPACA4, MIR940, EPN2-AS1, LINC01598, LOC157273, MIR663AHG, SUMO4, KLK2, MAJIN, SRSF12, MT3, LOC100129215, NLRC4, ANKRD2, MSC-AS1, SNORD118, MRGPRF-AS1, RYR2, SNORD3B-2, HCST, POU2AF1, CHRNA7, TMEM190, KRT33A, PCDHA2, PCDHA6, ITIH2, OVOL1-AS1, C8orf48, PCDHB3, PLCH1, DIO3, CD163L1, CARD17, ITK, LY96, PCDHB7, ALG1L9P, TMEM27, C16orf71, HIGD1B, LOC101927746, ZNF649-AS1, OR7E14P, BRSK2, SLC35F1, LONRF3, UG0898H09, TSHR, AGT, CHST9, IL20, RASGEF1C, EWSAT1, SNORA81, SRRM2-AS1, MIR1279, CD7, GBP5, MAMDC2-AS1, SLC26A4, KRTAP2-2, TEX101, SNORD86, PACSIN1, RPS2P32, C17orf99, SNORD5, PCDHA4, KRTAP2-4, LINC01060, STEAP1, LRRC73, CRTC3-AS1, FZD9, LOC102724301, LOC101928238, MIR202, C20orf202, PPP5D1, ARHGEF33, BATF3, SP5, ADGRB3, MESP1, CMTM5, CD8A, HOXA13, AKR1E2, PCDH17, C1QTNF9B-AS1, SP2-AS1, DNAH10, LOC345051, MIR324, RGS7BP, DIAPH2-AS1, KIAA2012, STC1, TCTE1, CD5, FAM3D-AS1, HSD17B13, LOC105376617, NODAL, MUC4, ERN2, CERKL, SNORD36C, LOC101927989, C12orf54, NPC1L1, ZNF835, LRRC66, PCDHA11, CHRNA2, TMEM74, HKDC1, ZNF483, FOXD2-AS1, CLEC18B, THEG, SNORD55, SYT5, SLC25A18, PTPRG-AS1, ALMS1-IT1, ITGA4, LINC01252, CCDC13, FMO3, LOC101928917, LINC00936, C3orf67, TH, NEBL-AS1, CAPN13, KRTAP4-7, ILDR2, LIPC, SSTR1, LOC105378405, EDN3, ITGB1BP2, SEMA3E, NUTM2G, TCEAL5, CDC37L1-AS1, MIR1244-3, CDHR2, SLC1A7, PARP15, FOLR1, CCDC162P, CD2, IL21R, IQCA1, NKAPL, SNAP25, ERICH5, GABRD, MGC20647, LINC01343, SNORD54, ... (+841 more) | 1040 genes (8.51-9.17): TLE6, VAX2, FOXD3, LILRB5, ALOX5AP, MAFTRR, KRTAP11-1, C16orf46, LAMA1, LINC01139, RAB44, MMP16, FLJ22447, TCERG1L, LOC101927755, SKA1, ZNF572, TMEM255A, HOXC-AS3, CTB-113P19.1, ZFHX4, ZNF702P, MMP27, AARD, MOGAT2, SLC2A6, TACR2, LOC339803, KCNK10, NANOS1, SUSD3, SLC22A31, DDIT4L, CAPZA3, LOC100996419, GGNBP1, COL4A2-AS1, LINC00106, LOC441242, SYN1, VMO1, LRRC6, SLC11A1, SNORD73A, RNF223, RBM44, SHISA9, KIAA0825, PPP1R26-AS1, MATN1, IL1RL1, KCNA6, AP1S3, FOXF2, KRTAP3-1, LCK, LIFR-AS1, CBLN1, ANO2, EMBP1, ACAN, SASH3, CCDC151, LOC284080, SPDYE18, BCAT1, NRL, LOC105378828, VAC14-AS1, LOC101929099, FAM71D, CFAP43, GPR63, LINC00638, GJA9, PATL2, AVPR1A, GREB1L, PLA2G7, LOC283140, POM121L9P, SLC22A18AS, ERCC6L, LCE3D, CIDEC, LOC101929295, VAV1, LOC100996246, ANKUB1, CELF4, HAGLR, LOC283299, SENP8, KCNT2, PFN1P2, CA4, AKR1B15, C19orf73, WTH3DI, LCTL, IGSF11, ATP8B3, LOC102723540, LCN6, GRIN2C, CYP24A1, APOC2, KCNB1, GALNT5, ZNF382, P2RX6, GPR160, ENO4, LOC728975, CYP46A1, SLITRK4, KIF5C, GRIK4, TAC1, CSPG5, CD33, COL4A3, LBX2-AS1, ADRA2B, LOC101929130, ADAM12, ACKR2, KHDC1, LRIT3, BLM, SFTPC, ITGA2B, ABCC11, LINC01091, TSLP, FAM196A, AQP11, LOC554223, LINC01136, CHSY3, ZFP57, SAA2-SAA4, HIST1H3E, C6orf15, HSFX1, APOB, REM2, CACNG4, HSH2D, IGDCC4, LOC100287290, UNC5B-AS1, TNFRSF10D, FSCN2, LOC101929988, EIF1B-AS1, RSAD2, RHOXF1, PPP1R16B, ECT2L, CLCF1, LINC00982, ZNF529-AS1, OBP2A, TAL1, NEURL1, LOC101928424, EXOC3L2, C2CD4B, TDRD5, NOS1AP, MRC1, XRCC2, ANGPT1, PRB1, WDFY3-AS2, ESR2, PWAR5, RSPH14, CLEC4A, FAM124A, FAM153C, JCHAIN, CEP19, GPAT3, ORM2, SCN11A, GAL, LRRC69, HAO2, ALDH8A1, YY2, COL26A1, AFAP1-AS1, LETM2, APBB1IP, SPRY3, LOC652276, FYB, FRMPD1, ... (+840 more) | 1041 genes (9.17-9.71): GIMAP2, TDRD10, ADORA2A, USP18, CDX4, MEX3A, EYS, LOC101928227, SPN, FOXI1, OXGR1, GRIK3, CKMT2, FOXA1, CBS, CD27, LOC100506098, LOC100505915, LOC107984921, RBPMS2, ZNF385D, LOC100287015, PPP1R1A, FOXE1, C2, SEC1P, PRR11, LINGO1, SCARNA17, RBAK-RBAKDN, CFAP57, TXK, GP1BA, CD1E, PGM2L1, MNS1, LOC553103, SWSAP1, ZFP82, ZNF222, LOC101929333, ADGRD2, CLEC1A, RBM20, MS4A6A, CASQ2, UBASH3B, ADAM28, MSC, MIR4435-2HG, WNT6, KCNJ12, PITX2, POTEI, CES1, C8orf37, UBE2Q1-AS1, SKOR1, CCL22, ZNF285, FAM24B, FOXN3-AS1, ZNF215, ZKSCAN2, MSMB, NMNAT2, IKZF1, LOC102724344, SEMA5B, RBKS, KCNRG, EFR3B, LINC01122, CCSER1, KCND1, ZNF713, MKRN2OS, HIST2H2BF, ST20, CCDC121, CCDC85A, SLC7A11, CCDC150, NRXN1, RBFADN, CYTH4, PLCL1, GOLGA8R, NT5M, PPP2R2B, WEE2-AS1, SPRED3, LRRC2, C10orf95, TPO, ETV2, ZNF436-AS1, C19orf71, CCDC30, KIAA1586, PBLD, FAM71F2, SPC25, FLJ27354, GLT1D1, SLC29A3, ZNF165, AK5, SCN3B, HOGA1, LOC105371730, RASD2, ATP8A2, LMO7-AS1, MAPK10, DNAH9, GNAZ, KRT86, PSPN, PSMD6-AS2, PIFO, GSTA1, CD83, CACNA2D4, TRHDE-AS1, CDH12, PRH1, WDR78, CFI, FAM149A, WWTR1-AS1, SH2B2, ZNF540, LOC102723505, ASB9, PROCA1, APOBEC3G, RET, PIK3R6, JAK3, ZNF484, MMRN1, IL17RB, OSCAR, KRT71, CD163, KCNH8, DUSP19, CTHRC1, SERPINI1, ADAMTS12, NINJ2, TRIM17, CELSR3, TSIX, FGG, KIF14, FAM223B, LINC01291, DOCK2, LOC284930, AFF3, ALDH1A2, JPH1, ZSWIM3, DLK1, TTTY15, SLC35F3, MGC16275, LOC101928464, ROPN1, PCDHB16, ARL9, C14orf39, GPRIN3, ASIC3, UCHL1, DENND5B, GALNT14, DACT1, SLC52A3, NRXN3, MAN1B1-AS1, LOC100505635, AKAP3, SLC9B1, FSIP2, DARS-AS1, TCEAL2, C17orf96, CPED1, EFCAB6, RAB17, SMIM10L2B, CD200R1, FAM171A2, INE1, SLC27A2, HOXA6, DPF3, ... (+841 more) | 1041 genes (9.71-10.20): NPTN-IT1, RAC2, C10orf128, FAM153B, NOTUM, MAP2K6, RAB30-AS1, UNC5CL, MARC2, CARD6, LOC105371795, TSPAN8, ACTC1, GUCY1A3, CNIH2, SLC35G2, POLN, MSMP, ROPN1B, TMEM56, PRKAR2B, TMEM206, LOC100499484-C9ORF174, CCDC138, LOC100130476, FAM86JP, AGAP12P, SLC16A11, INTS6-AS1, BDNF-AS, LOC100996447, KIAA1549L, FAM86B1, PARK2, SMAD1-AS1, CEACAM1, ASB14, PAPSS2, ZNF569, LPL, AURKC, ZFPM2, ANGPTL1, RND2, APOBR, RAB26, EDAR, FAM229B, GBP4, NAALADL2, GFRA3, TICAM2, GLB1L3, RPP40, TNIK, ZNF70, CUBN, GSN-AS1, COL8A1, GDAP1, GLB1L, KRT19P2, DLX4, LRRC39, CDKL1, FSD1L, MUC1, GRAMD1B, TNFRSF13C, CPVL, PSCA, MAGED4B, CPXM1, WDR31, PRCD, CMBL, AK8, SHROOM1, SEZ6L2, SLC25A33, LOC729867, BMS1P5, ALOX12P2, CHRM3, KTI12, THRIL, BEST2, C11orf74, RASSF8, SLC7A4, POLR3G, TACR1, BGLAP, ZBTB10, POC1A, NCKAP1L, HMSD, SLC27A6, PCDH12, PRSS36, CYP2U1, GPR35, AURKA, PSORS1C2, KCNQ1OT1, HIST1H2BK, NKAIN1, FANK1, SNCAIP, SLC35G1, ZSCAN16, PLA2G4C, TUBA8, NXPH3, ADM5, STRC, ZNF112, FIGN, SLC45A3, LINC00926, LRRC70, LRRC29, BEND7, BFSP1, FER1L4, STX19, MATN1-AS1, PCSK2, INE2, ULK4, C8orf88, FUOM, LRFN1, ALDH1B1, LOC646588, DPY19L2, CCDC17, PTPRC, ASGR2, LTF, DEAR, HIST1H2BG, C4orf46, PAQR8, IL10RA, GLI1, HS3ST3B1, CCDC144B, SATB2, ROCK1P1, FAM65C, PIGBOS1, RARRES3, ZNF790, GPR176, CLIC2, SCARNA2, SPRR2G, GATA2, ANKRD18A, SEMA6D, PLGLB1, KCNMB1, C2orf72, ZNF519, ADCY5, ZNF460, METTL12, SWT1, LOC100507373, LRRC49, FMO4, GRIN1, TBC1D19, SYTL4, KCNIP2, POC1B-GALNT4, ETV1, LOC729603, F8, GLYCTK, TOR4A, ZNF280C, PRIMA1, RGPD3, ICAM2, IFIT3, GRB14, ZNF79, WNT9A, NANP, ACOT11, SLC9A5, SPIN2B, B3GALNT1, CCDC28B, ORC1, TNNC1, DZANK1, ARHGEF38, ... (+841 more) | 1040 genes (10.20-10.60): GTF2H2C, FUT2, HSPB7, NNMT, TTYH2, CAMKMT, ZNF429, KCNJ15, KRT3, ZNF575, ZNF473, BIRC3, PNPLA3, ZNF256, ELMO1, TEAD4, STIL, CEP70, CCDC171, SOX9-AS1, FAM217B, CP, SLFN13, FLVCR2, CEP128, LINC01315, ARL6, EMILIN2, TRAIP, IRAK2, L3HYPDH, CCDC113, SAMD12, HOXC9, C15orf62, CYP11A1, FAR2, PTAFR, ZNF667, ANKRD29, HBA1, PEX11A, ZNF784, LOC100132215, TRPC1, CDC6, RUNX1T1, PYDC1, LSAMP, SP140L, EMX2, ZC4H2, SLAMF7, ZNF200, LOC101929709, ZNF614, TVP23A, ZNF287, CEMIP, SHROOM4, C1GALT1C1, LOC101928525, ARFGEF3, PIP5KL1, ATG4C, CPA3, RTN4RL2, GATA6, MBNL1-AS1, FRAT1, SULT1A1, TMEM38B, LRIF1, HP, MAB21L3, COL28A1, ZNF837, DSCAS, SLC46A3, USP35, IQCG, IL1R2, STARD4, PADI1, TMEM144, ADCY10P1, ATOH8, GSTT2, FAM166A, ZBTB26, SLC2A4, FAM171A1, RHOBTB1, GNG2, IL17RD, ATP13A5, MAD2L1, KTN1-AS1, TMEM51-AS1, TNFRSF6B, GRAMD2, WDR54, LIPF, ZSCAN22, FMC1, CSRP2, MEOX2, DUS4L, ADAMTS17, ZNF181, PFDN4, STARD3NL, ZNF493, RAB3IL1, LOC256880, CYP4V2, PKDCC, TEKT4P2, TMEM231, CCDC24, LMTK3, ITGA8, WDR5B, CEP57L1, IQGAP2, CASP9, ADAP1, NDUFAF4, CENPV, CD68, JPH2, KIAA1462, ZNF611, MAGI2-AS3, NCF2, JHDM1D-AS1, ZNF567, RINL, ST8SIA1, RN7SL2, SNORA70, AP4B1-AS1, KRT4, NHSL2, CCNYL1, ARC, E2F3, ORAI2, TBC1D3G, PRDM1, BCHE, CFL2, NAT14, RELL1, LOC105371049, ALOX5, ZNF772, C1QTNF3, TEFM, PGAM2, POLR3K, ZNF671, ATP2A1, PRC1-AS1, CFB, APH1B, TMEM133, GNG7, HSD3B2, TMEM150C, ERCC8, CCDC74A, SLC29A4, FBXL7, ZNF566, ZNF182, LOC100288181, FAM86C1, TIRAP, ADAMTS13, CCDC39, LSM11, FREM1, CD4, TYR, SEMA6B, TIGD6, CECR7, LRRC37A3, MTERF1, PRR15L, DTWD2, RBMS3, STK32A, B3GALT5, TNFRSF10A, RAD51, MPHOSPH9, GLRX, STAG3L4, ... (+840 more) | 1041 genes (10.60-10.94): MARVELD3, CBFA2T3, CRNN, HRH1, RIMS3, WARS2, FAM20A, THAP8, LIN37, KMO, TLCD1, MAP3K8, ZNF480, ROBO3, CYP20A1, ANKK1, NQO1, GGTA1P, TRIL, LGALS9, PCGF6, ZNF525, WNT5A, UBE2S, NOV, ZDHHC14, PROKR1, PEAR1, CDKN1C, GPR180, TRANK1, C6orf203, APOL1, LACC1, GPR68, ZNF354A, COA7, SAMD10, CLVS1, MAPK8IP1, CPNE8, CEP76, RBP7, MIR600HG, TMEM186, AMER1, RIMBP2, SLITRK6, NKD1, FAM102B, TMEM213, IFI35, KIF20B, ZSWIM4, PAM16, E2F6, LIN52, MYBL2, ANXA3, LCMT2, PRAF2, FAM69B, ZMAT5, CDCA3, MDP1, KIAA1683, CFAP157, ZDHHC11, SLC36A4, CCNF, PDE4B, GLA, SLC35E2, MYEOV, GALNT16, RSC1A1, ZUFSP, OSR2, BLOC1S4, CNPY4, EVC2, TNFSF13, SCD5, ARG1, FAM95B1, TMEM143, THAP6, FKBP9P1, GLI2, TMEM204, HAGHL, PAXIP1-AS2, SSC5D, ALDH1A1, TMTC1, TMEM14A, KCNMB3, HERC2P3, CALB2, METTL1, RIPK2, STARD13, SLC30A4, EID2, TGFB3, ERI1, RNFT1, RNF207, NFKBIE, SDHAF4, RILPL2, C10orf88, TRIM6-TRIM34, ARL13B, ALDH3B1, TNFRSF12A, TP53I3, MLYCD, KIF2C, SHCBP1, ZNF593, ANKRD49, SLC2A3, SPIRE2, RCBTB2, MYOM2, LGI3, WDSUB1, WDR89, TRIM34, LINC01176, CCNB2, ZNF773, NBPF25P, MNAT1, SMPD3, PLSCR1, TMEM267, CTNND2, KIAA0895, TARSL2, DQX1, PIN4, LOC339260, PGM5, ZNF41, DGUOK-AS1, EMID1, SPSB2, ABCA11P, SSPN, CD320, ZNF607, POLG2, ZNF136, PGBD2, PRIM2, CIB2, MAGOHB, TRPC6, IGFL3, RFTN1, OSGIN2, C1orf226, GINS3, ZFAND4, TMEM55A, EBF4, FHOD3, MTRF1, PLA2G4E-AS1, GEMIN8, TBC1D32, THEM4, TTC28, UMAD1, PET117, LOXL3, ZWILCH, HIST2H2AA3, HSPA12B, SLCO4A1, HSD17B11, GHR, MRPS31P5, B3GNT2, SLX4, BBS10, UBE2C, TRNP1, TUSC3, F10, ZFP30, RNF125, ZNF468, PDLIM3, TRMT1L, BST2, LINC01503, CEP135, ... (+841 more) | 1041 genes (10.94-11.23): F12, ARHGEF35, NEK4, RNF216P1, LAMA2, TRIM16L, SERF1A, MRGBP, FGGY, DDX20, FAM198B, TSPAN11, CCDC73, FMO5, GDAP2, ZBTB34, C19orf68, ZXDB, NARS2, C8orf76, RASSF10, AHRR, ZNF517, CDH11, CCDC102A, GPRC5B, TAF4B, ENOX2, BAIAP3, PDE5A, BPGM, SNAPC1, SCRN3, LIAS, TBCCD1, SPNS2, PCNX2, NSMCE2, FGFRL1, CEMP1, SAC3D1, MAT1A, CDK8, SLC38A7, TCEB3-AS1, ARHGAP8, CDH5, ZNF329, TSPAN6, TTC28-AS1, AS3MT, TMEM70, ASB7, NDUFAF1, CNEP1R1, TCP11L2, MAOB, CCDC149, KIFC1, BID, CCDC28A, P3H3, MFAP2, SLC1A6, HACL1, FEN1, RNF113A, ZNF526, HID1, GNPNAT1, ABCA8, DCHS1, RPS26, VOPP1, LIX1L, NME7, BEX2, C19orf54, NDUFAF6, MISP3, JRK, NKRF, RBM5-AS1, ABCC4, RNF166, MIR22HG, EPB41L3, PMAIP1, PAFAH1B3, BIN1, CIT, PET100, UHRF1BP1L, PRKCB, USP49, C1orf204, MARVELD2, MPZ, ADORA2B, SPTB, HOXB2, FASTKD5, MAP3K9, GTDC1, FCHO1, LOC100128770, ASCL2, SLC35E3, TRIM45, ZSCAN32, EMX2OS, ARMCX5, GATS, SH2D4A, GEMIN7, HSD17B7, SEMA3B, DCST2, ZNRD1, TCONS_00029157, METTL15, GPR75-ASB3, ARHGAP39, BLNK, HLA-DMB, TMEM243, FANCD2, NTF4, GEN1, BMF, DCP1B, BASP1, TOR2A, UCP2, UTP23, DTNB, IDI2-AS1, DENND6B, C1orf210, ABO, PI4KAP2, BMT2, G6PC3, ARHGAP28, ITGB3BP, PGA4, OLFML3, NFU1, BORCS5, C6orf141, TTC32, SLFN5, C11orf71, GSTA3, KIF2A, KIT, NEMP2, CDKL5, C5orf46, KIF3A, CUTC, AK6, COMMD10, MGAT2, CEP78, KLF12, PODXL2, CD93, TPRKB, TTI2, HOXA10, OMA1, GTF3C2-AS1, CWF19L2, SWI5, ZNF518B, FAM209A, CSNK2A3, HLCS, SNTA1, DUSP6, CACFD1, FANCF, C10orf2, RGPD8, LOC440434, DLK2, ZNF304, SAMD4A, PRMT9, CD72, TRAF6, NPY1R, CASP6, DEPTOR, DHRS12, HOXA3, FMNL1, CSGALNACT2, TRUB1, ... (+841 more) | 1041 genes (11.23-11.50): TIGD5, PPIL3, SYNC, SSX2IP, DTWD1, MED26, ANGEL1, C1QTNF1, MCPH1, GPATCH1, SERHL2, SNX16, AASDH, LYPLAL1, ORC3, CTSL, ANG, NIP7, NACAP1, NEDD4L, GOLGA6L9, TMEM126B, VILL, PMS2, ANKRD46, NACC2, CLDN12, SNX24, C12orf75, PRDM15, SMS, DLGAP4-AS1, CPXM2, C8orf58, PEX7, PRPS1, SORL1, C11orf54, CALML4, GNPDA2, TMOD1, IFI27, ANKRD36, MRPL58, FHL3, MRPS33, MGST1, LOC101929240, TNFAIP8L1, ZNF662, CACNA2D1, FSTL3, LURAP1L, DHRS4-AS1, FYN, SLC25A40, SH3BGRL2, SERINC4, LIF, EPHB1, FKTN, FGFR1OP, MAP4K2, TM2D1, GMDS, ACP6, ABHD10, ZNF786, PRICKLE2, DECR2, SGCB, C15orf59, RRP9, HPF1, MRPL44, SPECC1L-ADORA2A, MRPL47, C15orf48, KLHL2, LZTFL1, RRS1, PLAGL2, ISM1, ZNF330, RASGRP1, ZNF467, SURF2, KLHL28, CHCHD7, TCF7L1, SYT17, SEMA4G, PIBF1, LPAR3, PI16, TTC5, SCNM1, RAB27A, SRPK3, QTRT2, ACD, RGL1, SEC24D, APBA3, MYH7, RALGAPA1P1, TMEM102, COL8A2, TUBG2, SELENOM, NDUFAF5, NAT6, FIZ1, PSMB9, ZFY, EMP3, C3orf62, LAGE3, SULT1A4, NSUN4, HLA-G, CCDC91, FANCL, CEP44, SLC17A5, RPAP2, ZNF33B, PRPF18, AP3M2, PHKG1, PRIMPOL, LRRC75B, LCORL, C12orf65, ADCY2, CHIC2, ALG6, CRB3, RBMX2, LOC105378872, L2HGDH, CLDN5, CCDC82, TMEM201, SNUPN, METTL10, TIMM9, SNRPE, TCTA, ZBTB45, VWA8, GPX2, MRPL54, PTGR2, SOX10, SLC25A4, MRPL21, LPAR1, DUS2, PFKFB2, CSF1, CCDC94, CACNB1, GSAP, SERPINB12, VPS18, TTC12, KATNA1, PRKCA, ACSL4, ARRDC2, TIMM21, TMEM45B, ZNF26, SLC18B1, PITPNM1, IFT20, SCARA5, CARMIL1, MRPL48, FUZ, CREB3L4, SPICE1, KIRREL, BANP, ZNF548, MAN1C1, DNHD1, NAA35, CFAP36, GALK1, ARHGEF16, CAAP1, PLCG2, EMSY, INTS2, LOC101927051, EPS8, RPS28, TMEM161B, ... (+841 more) | 1040 genes (11.50-11.74): POLR2I, CRLF1, MYO1B, CHRNE, OGG1, FAM122A, TM2D2, AP4B1, CLCA4, RRAGD, SLC33A1, INTU, FAM220A, MYCBP2-AS1, GRIP1, LIMK1, VIPAS39, ANKRD39, PPP2R1B, CPE, MRPL2, POP4, POLR3GL, FAM136A, SLC16A14, RBAK, HIBADH, GALNT6, GPKOW, PTPRU, RBBP9, TCEB1, BAG4, TP53RK, XXYLT1, AGTRAP, SMIM12, USP30, KIAA0922, KPNA2, ARSD, PPWD1, EPB41L5, MBIP, FMOD, ARL5B, ABI3BP, RASA4B, PSD3, ME2, KCNC4, PTGER3, ELP3, ARHGEF39, NATD1, DDX10, C11orf98, CX3CL1, POLR1C, CENPBD1P1, MAPT, GATB, TDRD3, PPIL4, AARSD1, HDHD2, EFL1, BAK1, NSDHL, ALS2, CHST15, EXD2, PDGFB, ELF4, DYNLT3, SLC30A7, ZBTB18, ZNF622, PXN-AS1, STARD9, COG6, ZNF528, BTN3A3, AKR1B1, SRP19, SPAG16, SYNPO2, RUNX3, STYX, DIRC2, TRIM3, LHX2, CAMTA1, GOLPH3L, IFT57, FAM45A, DHTKD1, IFI27L2, TMEM223, SIRT3, NOD1, UBALD1, SLX1B, ZNF587, SSH2, MRPL10, FAM76B, TRIT1, TUSC2, DCAF13, RAB11FIP5, RHBDD1, IRF7, FDX1, NEU1, PHAX, AR, ZDHHC1, SLIRP, SPRYD4, PHF5A, MAP3K13, USB1, TMEM261, RALGPS1, TRAM2, ODF3B, TSTD2, RHNO1, FPGS, ALKBH3, EIF1AD, ZNF518A, PPARGC1B, HCN3, MRPL11, RPS6KA5, SMARCAL1, POLR2F, B3GALT6, ZNF205, MTIF2, TRIB3, MCM9, WHRN, SIRT1, TBC1D25, NEB, ZNF91, ABRACL, HYAL1, EIF2B3, SLC25A27, TCEA2, NUDT16, ATP6V0A4, IQSEC2, DERA, HS2ST1, PLEKHG1, SLC35A1, ASNSD1, BNC1, WFDC21P, RBM18, HSBP1L1, PMS2CL, DIABLO, DCAF17, COX19, RHBDD3, SCMH1, TRMT44, CBR4, LSM8, TUSC1, FRS2, ATF2, FAM129A, TST, SELENOK, ZNF84, CCDC86, NUDCD2, MRPS9, FAM160B1, TRIAP1, TUBG1, TP53TG1, MED10, POMT2, TK1, TNNT2, GTF2B, C1orf123, EPC2, NMNAT3, TRAK2, ELK1, HMGXB4, ... (+840 more) | 1041 genes (11.74-11.98): TOP2A, FBXL16, TAF9, NBPF1, TCF19, TREX2, HIVEP3, TMEM110, TXNDC17, RAPGEF2, DYRK2, ATG5, FOPNL, FOXO4, LY75, OSBPL6, GFOD2, VAMP4, JADE1, KCTD12, UBQLN2, NOM1, SFXN1, LIME1, SEC14L2, TMEM18, MSI2, CDC73, EIF2AK4, TEN1, FNDC3A, RTN4RL1, TBC1D16, CDIP1, C12orf29, THEM6, CENPX, UCK1, XYLT1, ATP5S, VPS37A, TIPRL, COA1, HCAR3, FAR1, RPS27, MAFG, RFFL, TCEAL8, DNAJC17, C8orf59, CCNH, COPS8, MAD1L1, NTRK2, C19orf70, CNOT10, BLOC1S6, AKIRIN1, HLA-DPA1, SERINC2, UBE2Q2, INTS5, AIP, ZNF623, POLR3A, MARCH8, FAM98A, EXOSC8, ECD, NBPF15, CDK17, MELTF, ME1, RRP7BP, LOC283335, PEX11B, CNTD1, IL1RAP, SDC2, UFL1, TMX3, HDAC4, TXNDC15, ARHGEF3, PDCD10, ZNF398, RACGAP1, KLC4, CHST12, PTPN18, TERF2, CHTF18, LIMCH1, SPEG, GLCE, SPRY2, MMP19, SMG9, TM2D3, TREH, DRAM2, NOMO3, CCNB1IP1, LRRC42, FAM189B, NDUFAF3, ZNF33A, C19orf66, IPMK, HCG25, TVP23B, ZNF451, INPP5F, PURA, KLF11, ACOT7, CGN, MARCH9, VPS9D1, TRAPPC2L, ORC2, CREBRF, SLC25A22, ACTA1, ZNF561, PGGHG, DUSP23, GUF1, CLCN6, CAB39L, GRAMD3, SNRNP40, AGGF1, ELOF1, ZNF133, ALG9, PCDH7, PEAK1, UBLCP1, ZFPL1, PGS1, OGFOD1, GNA13, PELO, CLPP, CDCA7L, RPE, NMD3, ATPAF1, TAF11, RRP12, ZMYND19, NOA1, THOP1, EXOC2, RCN1, SNN, TMEM185A, MFSD3, AVL9, XPO4, RBBP8, MFAP1, TMEM161A, SHANK3, DAGLB, LIPM, SLC15A4, TMCC1, TIMM17A, NFATC1, HMGCL, CFAP20, WHAMM, PFDN6, MCRIP1, RFC2, STAG3L5P, TOP1MT, MIR568, POLR2M, ZNF318, LRCH3, WDR20, C2CD2, NUDT16L1, ENTPD5, MRTO4, CHURC1-FNTB, SGK3, METTL5, CHAF1A, SLC35B2, DUSP14, ORMDL2, MST1, UGT1A6, FAM214B, NDUFV3, ... (+841 more) | 1041 genes (11.98-12.22): PHF11, DLAT, ZMYM3, CHI3L1, SLC22A5, CUL7, ENOPH1, TRAPPC11, GPT, SFI1, RMDN3, EDC3, TOMM40, ACSL3, ELOVL6, F3, PHF13, PPM1F, CBX4, TIMM50, CCDC97, RAP1GDS1, NOSIP, PTPN2, PLPPR2, BROX, RPAP1, ACBD6, NMRAL1, SETD4, TEAD1, PTPN6, THUMPD1, APEX2, SMPD2, CEPT1, KANSL2, SAV1, TPRG1, FAM149B1, MCOLN1, NAE1, PFDN1, CCNT1, SSH1, MLST8, ADAMTSL4, ARHGAP21, STK19, NPAS2, SMN1, SLC25A26, KIAA0196, MYADM, TMEM183A, PLEKHG4, GTF2F2, MAP2, FAM127B, ANKRD28, FAM46A, SYK, BARD1, REST, APPBP2, CMAS, FAM199X, CEBPZOS, MRPL30, NOL12, CDC27, RNA5-8S5, ZC2HC1A, VWF, IFT122, TBC1D15, REL, PXDC1, PARL, PLRG1, PHF20L1, DNAJB11, TOR1AIP1, GSTO1, CHST2, DTX2P1-UPK3BP1-PMS2P11, ATP8B1, PDK2, FAM50A, SLC5A10, RBM22, LAMTOR3, VPS33B, WARS, HELZ, PLEKHA5, HERC4, SLC52A2, PP7080, BOD1, KRT16P3, CWC15, HEXIM1, BAZ2B, STRIP1, ZFYVE19, BCAP29, TSSC4, SIAE, EXOSC6, BIRC2, DIS3, PTCD1, PMM1, TARS, ZDHHC12, WDR43, INPP5A, RNF169, TMEM138, RAPGEF6, ZNF710, RPS6KB1, SH3PXD2B, SLC9A1, GPN2, TANK, PIGN, GUSB, EVI5L, SNAP23, ABCA1, MANSC1, FAM8A1, GPN1, CABLES1, MON1B, CRBN, IL4R, TFCP2, SNRPN, CASK, PSIP1, PYCARD-AS1, NEPRO, HAT1, LUZP1, STRADA, ACP5, SDHAF2, CYR61, DHRS4L2, RFXANK, RPL23P8, GRK6, MORC4, FAM120B, NOL11, HEXDC, GTPBP3, RAB11FIP4, RECQL, C16orf62, CRTC3, IFT27, SCOC, CCM2, ITFG2, ITFG1, ETFDH, PRMT7, CCNC, TP53I11, ST7L, FTO, CHD1L, OSTC, KRIT1, KRT7, CPD, TFDP2, MRPL12, NUDT22, SDAD1, PGM3, DOPEY2, RAB11FIP3, ERLIN2, ACTL6A, MAP2K1, NOL8, FAM98C, MRPS21, FARSB, FAM114A1, TMEM184B, NDUFC2-KCTD14, RBP1, FAM110A, MED29, ... (+841 more) | 1040 genes (12.22-12.47): CD276, HAX1, USP8, ABCB9, THAP9-AS1, USP31, RNASE4, MAPKAPK5, TRPV3, NSMF, STIM2, MFSD12, CAMSAP2, USP21, WDR34, MVK, FHDC1, VPS29, TRIP10, B3GAT3, CPSF2, URGCP, VWA1, RNF123, CNNM2, ARMC8, TRAPPC1, ZBTB38, THAP3, C19orf53, MYSM1, TXNL4A, OSBPL3, HARS2, POMGNT1, FAM89B, COG3, PGM1, ADH5, GSTM3, UGGT1, EXOC5, ARFIP1, GAB1, PWP1, NPHP4, MGME1, TMED7, RING1, NME3, MRPS18B, RCN2, KRT222, CALU, CAD, DAPK3, LOC102723897, NPC1, GPRC5C, PRKAA1, NUP50, MYO5B, ATXN3, HN1, CHPF, NOP58, CMYA5, EIF4E2, LINC00667, MANF, ACADSB, TRADD, ERF, MAPK7, TM9SF1, WDR81, ZNF106, RNF103-CHMP3, CARS, PIAS1, SURF6, DNTTIP2, VPS45, POLR2G, DRG2, PHYKPL, SNF8, MTMR4, CYTH3, DEF8, HLA-L, SETD1A, SARNP, C18orf25, LMBRD1, SACM1L, SLC5A2, GAS1, OVCA2, PSMA3-AS1, C22orf29, HADH, ARL4D, WDR73, CEP95, PIP5K1C, RPS6KA3, LPCAT4, TSR3, ATXN1, CREB1, TMEM164, LDLRAP1, STX5, TBC1D2, NRAS, ETNK1, CHSY1, TOR1AIP2, TPD52L1, HOXA9, MED25, SIRPA, PIGQ, YIPF4, UFSP2, TESK1, IWS1, PLAU, UFM1, SLX1A-SULT1A3, DSTYK, TANC2, ATG2A, DNAJC4, RGPD5, RPRD2, CAPN3, QTRT1, KCTD7, SRP54, ILKAP, RNASEH2C, MAP3K7, ABTB1, GCC1, CHFR, VPS13B, MPDU1, MPPE1, PREPL, TEX2, PRMT5, YTHDF1, PSMA3, RCAN3, LNPK, WNK2, ITPKB, NT5C2, NSA2, M6PR, SPTLC2, ID3, ADGRG6, TRPV6, ITPA, IL33, PLEKHA7, TLK1, MECP2, PLA2G6, LDLR, RTKN, CYP3A5, HDAC11, LINC00511, PLIN2, PATL1, TMC6, LRRC1, AAAS, DCAF12, NSMAF, URM1, SNAI2, SOX15, TNKS, ZNHIT1, FBLN2, THADA, SRGAP2C, TMUB2, RAB22A, GTF2H1, NARFL, PEPD, DAD1, C20orf24, TRMU, ... (+840 more) | 1041 genes (12.47-12.75): DAXX, LOR, RNF185, OLA1, EMD, EIF2B4, TEPSIN, MTOR, DMAP1, BTG3, CGGBP1, STARD3, EXT2, SHARPIN, MTA3, CBFA2T2, TCEB3, OGFR, CTTNBP2NL, PLK2, C11orf49, TSPAN5, HMCES, IDH3G, RIPK4, WIPF2, MYO15B, LAMA3, EIF2D, BCR, MYO6, PPM1A, SESN1, HSF4, AURKAIP1, ZNF692, BABAM1, PARM1, ACAA1, FAM83B, MIGA2, GPAT4, ESRRA, KAT5, RALGPS2, GGCX, SEL1L, SGTA, PHYHIP, SGK1, PPP1R7, MBNL2, SEC13, PSMC6, RPA2, ARHGAP17, TYRO3, LAPTM4B, CNFN, ATP1B1, PHF21A, SFXN3, BTN3A2, PACS1, OXSR1, SETD3, EFNA5, DMPK, RARS, WDR45, ASB6, IGF1R, SLPI, MORC3, FBXO9, VAPB, MRPS25, MAPK3, BDH1, COG8, VDAC3, GPR87, PAPLN, UQCRQ, NCAPD2, TEX261, SQRDL, KMT5B, PPP5C, ANKRD10, BBIP1, AMFR, COX7A2, NOL6, PRKCD, EIF4G3, TOMM70, NCS1, SH3D21, GATAD2B, SRSF8, RHOD, CSK, TYMP, UQCRH, C6orf48, ERMP1, KLHDC8B, PRCC, SF3B4, ZNF384, BRD3, DHX8, POLRMT, TGFBR2, E4F1, HIGD2A, CAPN15, LAMC2, PHF3, HCFC1, PCIF1, ADSS, CNOT8, TOB2, PDK1, MAPKAP1, HERC2P2, MRPL37, CD34, HSBP1, CITED2, BNIP2, SLC7A6, PCMT1, IL6ST, FAM3A, CYCS, DKC1, CREBL2, SCAF8, HLA-DRB1, SIGMAR1, EIF2B1, IFNGR1, NDFIP1, USP40, ATAD3B, PPIG, SART3, TM7SF3, MFSD1, RCOR3, PEX10, STX6, UCKL1, UBR2, TBC1D5, WDFY3, FOXJ2, TCEA1, PTDSS1, RABGGTB, SCPEP1, DOPEY1, SMU1, FAM21A, XPNPEP1, C1QBP, ASH2L, TPPP, USP12, SMARCB1, IRF2BPL, WDR5, IMPAD1, PNKP, MICAL3, DGCR8, APMAP, MRPS34, MMP28, PGD, FAN1, IP6K1, HDGFRP2, RYK, ACTR10, SF3A3, HSD17B10, EHD1, SUMO1, FRYL, TMEM147, USP48, NFX1, EIF2S1, PACSIN2, PPIL2, RHBDF2, ... (+841 more) | 1041 genes (12.75-13.13): HDAC1, KIF13A, EPHA2, PAN2, MAPKAPK2, RBM8A, ATF7, OXR1, ABCD3, YKT6, C16orf58, BAG3, MFSD14B, SEMA4C, SERPING1, WHSC1L1, BACH1, APEH, UBE2L3, KIAA2013, MTA1, R3HDM2, AK4, MAP3K11, SIN3B, UBE2D2, RAB3GAP1, EFNB2, CSNK2A1, A2M, MARK3, SCYL1, RBMS1, DMTF1, EP400, DARS, PSEN1, NMT1, SNU13, MTMR10, ZNF598, POLE, NCOA3, SERPINB7, TBCD, MAF1, COQ4, OSBPL5, ZNF316, UBE2G1, DEGS2, OAZ2, TPM2, PQLC1, IDE, ZER1, ARL6IP1, COG5, ADGRB1, NUP188, CCT2, PSMF1, VPS4B, ALDH7A1, AP2A2, AADACL2, DDX41, PPME1, ZYX, PPP2R2A, LRRC47, TFCP2L1, NPIPA7, PRMT1, SART1, ERBIN, NSUN2, CXXC1, RBM17, UBE3C, DSE, GPATCH8, LARS, LARP4B, FLOT2, EFTUD2, CARM1, POLD2, NOP9, TRAPPC12, MROH1, BARX2, ATPIF1, ATP6V0E1, FBXO27, BRAT1, TCEA3, RSRC2, PTPN11, GPR157, NECAP2, MMADHC, SNHG1, GATC, PANK3, KDM1A, ZFYVE21, TAOK2, KANSL1, CAT, FBXW4, UBP1, EIF2B5, PGM2, TMEM50A, KRT75, PTPRS, OSBPL8, PPP1R10, MAP3K2, ABCA5, ZMAT2, PDCD6, TNFRSF14, SNX33, C10orf54, PDAP1, KLHDC2, DYNC1LI1, UBE2R2, ENDOD1, MATN2, GRHPR, MUCL1, SLC4A2, HN1L, KCNK6, SH3YL1, HPS4, ERCC2, RBFOX2, PCF11, FBXO42, LASP1, DUT, RNF11, GGA2, YIPF3, RMND5A, MRPS27, ZZEF1, UBE2K, SDHA, CXCR5, HNRNPH2, SSBP3, LMAN2, AFTPH, XPO6, DCAF5, RSRP1, NDUFA4, CD55, EML2, POLR3H, DDX19A, ESYT1, ARFGAP1, TET2, PSMA1, AGO4, SH3BP1, AKAP9, ERCC5, CLIC3, RTF1, BRD7, RAB21, MKL2, OSBP, TCF3, CYTH1, PPP2R5A, HDAC2, TMBIM4, SUSD2, FCGBP, RNF126, SLC25A11, LOC100128494, CLK3, CUTA, GLOD4, TNIP1, PAX8-AS1, SCAF1, CDKN1B, ALAD, YLPM1, MYL6B, ... (+841 more) | 1041 genes (13.13-14.03): TSC22D3, MDH1, SZRD1, TRIP12, IDS, ATP5H, EXOC7, YWHAG, SCNN1A, CCT8, COMT, TATDN2, SNHG5, EPHX3, PNN, HNRNPA0, USP5, CCT5, ARHGEF7, PRR12, ACTR2, CPNE1, ASAP3, CERS3, ATP5C1, COPA, KDM5A, MED15, LAMB3, INTS3, MYO1D, CYBRD1, ARL6IP4, HTT, EIF2AK1, ADIPOR1, IGSF3, SAT1, CPSF7, NDUFB8, PSMB1, MCC, NFIB, KMT2E, CREBZF, RAB2A, TGOLN2, GATAD2A, ARPC5, NSFL1C, SEPT8, GBP2, CELSR1, ATL3, SKI, ASAH1, ANXA11, GNAI3, HRAS, SVIL, SNX3, SCAMP2, KIAA0368, MAZ, RABL6, DUS1L, PRKDC, CNN2, CAV1, DNMBP, KIAA0930, MAP2K2, TBC1D14, SERINC1, NRBP2, LSM14A, CALD1, BTBD2, POLR2E, MBD2, NRBP1, RTCB, OTUB1, CLN3, MAN1B1, LTBP3, YY1, RAD21, ZNF273, CFLAR, IPPK, PPP1R15A, CLDN4, RAB6A, AAMP, GLG1, HEBP2, SLK, LTBR, TAF10, FOXN1, C1orf106, MBD6, WDR82, INTS1, FKBP5, PSME1, PLD1, ANXA7, DVL1, PNPLA2, ATP5O, PTPN3, H3F3A, SMG5, WEE1, USP34, RNF167, PCSK7, SLC6A9, MARCH6, TRA2B, CYFIP1, DDOST, KHDRBS1, CTDNEP1, KDM5B, TBL1XR1, DIP2B, NEO1, TMEM254, DHX9, SEC24C, ATF6B, WFDC5, ATP6V1C2, ATP5G3, COX7C, TMED3, CD63, ARHGEF19, IER3, VPS36, PLEKHM2, SLC3A2, FGFR2, PCYT1A, SRSF9, VAMP8, FAM160B2, STAP2, RNPS1, GBF1, TMEM159, CHMP3, NPLOC4, SUMO2, TM9SF2, SEC31A, KHSRP, NCCRP1, KREMEN1, KHNYN, SERPINA3, ANXA4, PTOV1, IP6K2, SCARB2, TMEM134, CIC, SERPINA12, RSL1D1, EIF5, ARID1A, ZNF703, ATL2, SF3A1, TSC2, DDX42, CD109, UBAP2L, SRP68, PRPF19, HIP1R, MLXIP, SLC2A4RG, PSAT1, UBQLN1, CCAR2, PALMD, FKBP1A, NR4A1, PFKFB3, SMPD4, AP2A1, ATG9A, AKAP13, CLTA, RNASEK-C17orf49, ABHD17A, ... (+841 more) | Top-400 expressed: KRT10 (18.78), KRT1 (18.70), COX1 (18.18), ND4 (17.77), KRT14 (17.74), COX3 (17.66), KRT5 (17.54), KRT2 (17.25), ATP6 (17.24), CYTB (17.17), COX2 (17.15), ND2 (17.03), DSP (16.91), EEF1A1 (16.73), PERP (16.66), ND1 (16.62), PKP1 (16.43), LGALS7 (16.43), AHNAK (16.28), DMKN (16.28), JUP (16.28), RPS6 (16.28), ACTG1 (16.22), RPLP1 (16.19), TPT1 (16.13), RPL13 (16.04), RPL3 (15.98), RPS18 (15.98), KRT16 (15.96), HSPB1 (15.95), ND5 (15.94), ACTB (15.94), TRIM29 (15.90), KRT17 (15.88), RPL4 (15.86), EEF2 (15.84), GSN (15.83), ATP8 (15.81), ND3 (15.79), B2M (15.78), RPS8 (15.77), UBC (15.76), RPS4X (15.75), RPS3 (15.73), KRT6A (15.67), SBSN (15.66), RPLP0 (15.64), RPL8 (15.64), HLA-B (15.62), KRT6B (15.62), RPL13AP5 (15.59), SDC1 (15.59), NEAT1 (15.58), CXCL14 (15.58), DSC3 (15.58), COL17A1 (15.57), SFN (15.57), RPL13A (15.56), RPS19 (15.48), FGFR3 (15.47), GJA1 (15.46), GAPDH (15.44), DSG1 (15.44), COL7A1 (15.44), PTMA (15.42), RPS11 (15.42), RPL19 (15.41), RPS12 (15.41), RACK1 (15.37), RPS14 (15.35), H3F3B (15.35), SRRM2 (15.35), MALAT1 (15.34), CALML5 (15.33), KRTDAP (15.32), CDHR1 (15.31), RPL11 (15.30), NDRG1 (15.29), RPL10 (15.29), RPL18 (15.27), CALML3 (15.27), RPL37A (15.26), ANXA2 (15.25), ND4L (15.24), RPS9 (15.22), AHNAK2 (15.21), DDX17 (15.20), LYPD3 (15.19), RPL5 (15.19), YWHAZ (15.16), RPS24 (15.16), RPL7A (15.15), RPS2 (15.14), PABPC1 (15.14), NACA (15.13), DHCR24 (15.13), RPL28 (15.12), ZFP36L1 (15.11), RPL32 (15.10), EEF1G (15.09), RPL30 (15.08), RPL23 (15.08), RPLP2 (15.08), AQP3 (15.07), KRT15 (15.07), CD44 (15.06), ND6 (15.06), SLC2A1 (15.05), DEGS1 (15.04), ITM2B (15.04), PLEC (15.04), LMNA (15.04), HSP90AB1 (15.04), RPS5 (15.03), RPL10A (15.01), CASP14 (15.01), RPS17 (15.01), ALDOA (14.99), HLA-A (14.97), FOS (14.97), S100A14 (14.97), DCD (14.96), RPS20 (14.96), RPS23 (14.96), EIF4G2 (14.94), GLTSCR2 (14.94), RPL15 (14.93), EVPL (14.93), PTPRF (14.93), RPS16 (14.93), RPL27 (14.92), TMEM99 (14.91), GPNMB (14.90), LY6D (14.89), TMEM45A (14.89), HLA-E (14.89), RPL31 (14.89), KLF5 (14.88), RPL37 (14.85), RPL29 (14.85), PKM (14.85), ENO1 (14.85), MYH9 (14.83), RPS15A (14.83), PPL (14.81), FLNA (14.81), HNRNPH1 (14.80), CLDN1 (14.79), HNRNPA2B1 (14.78), RPL17 (14.77), RAPGEFL1 (14.74), HSP90AA1 (14.74), P4HB (14.73), CST6 (14.72), KRT77 (14.71), CTSD (14.71), MYL6 (14.71), DUSP1 (14.70), HLA-C (14.70), EPHB6 (14.70), SERPINB5 (14.69), S100A16 (14.69), RPL34 (14.69), RPL12 (14.69), SLC38A2 (14.68), CTNND1 (14.67), HOPX (14.67), DST (14.67), RPS27A (14.66), YBX3 (14.66), ALDH3A2 (14.66), ATP5B (14.66), RPL35A (14.66), RPL27A (14.66), LDHA (14.65), RPL35 (14.65), TAGLN2 (14.65), KLF4 (14.65), VIM (14.65), TACSTD2 (14.65), DDX5 (14.64), NECTIN1 (14.62), LGALS3 (14.62), HSPA5 (14.61), MACF1 (14.61), PSAP (14.61), IFFO2 (14.60), LAD1 (14.60), RPS15 (14.60), RPL26 (14.59), RPL14 (14.59), ATP1A1 (14.59), HNRNPK (14.58), TMSB4X (14.58), GPC1 (14.58), EIF4G1 (14.57), RPL36 (14.57), PKP3 (14.56), PLA2G4F (14.55), NUMA1 (14.55), NOTCH3 (14.54), LRRC75A-AS1 (14.54), BTF3 (14.53), EIF4A1 (14.53), ACTN4 (14.53), CFL1 (14.53), SENP3 (14.53), SLC25A6 (14.52), APOE (14.52), CD9 (14.52), OAZ1 (14.52), DSC1 (14.52), RTN4 (14.51), SNRNP70 (14.51), DDR1 (14.51), GSTP1 (14.50), GLTP (14.50), UBA52 (14.49), ATP5A1 (14.48), RPS13 (14.48), LINC00842 (14.48), CIRBP (14.47), EZR (14.46), LENG8 (14.46), LAMA5 (14.46), GNAS (14.46), TP63 (14.45), EIF1 (14.45), SCEL (14.44), SPINK5 (14.43), EEF1D (14.43), CSNK1A1 (14.43), CA12 (14.42), KRT6C (14.42), DDX39B (14.40), EMP2 (14.39), RPSA (14.39), ATP1B3 (14.39), CSDE1 (14.39), CALM2 (14.38), ABLIM1 (14.38), HR (14.38), CD81 (14.37), UBB (14.37), IRF6 (14.36), ZFP36L2 (14.36), BTG1 (14.36), EIF3L (14.36), NCL (14.35), CAPN1 (14.35), GATA3 (14.34), ANXA8 (14.34), JUN (14.34), PCBP2 (14.34), SPINT2 (14.34), DSTN (14.34), EIF4A2 (14.34), ARPC2 (14.34), RPS25 (14.33), SRSF5 (14.33), PSORS1C1 (14.32), ACADVL (14.32), APP (14.32), RHOA (14.32), TNKS1BP1 (14.32), PPP1R13L (14.31), JAG1 (14.31), CDSN (14.31), MINK1 (14.31), PPIA (14.31), TXNIP (14.31), ACAP3 (14.31), ALDH2 (14.31), SPTBN2 (14.30), RPL24 (14.30), EIF4B (14.30), RARG (14.30), RPS3A (14.30), RNH1 (14.29), BHLHE40 (14.29), YWHAE (14.29), SPRR1B (14.29), COL6A2 (14.29), RORA (14.28), LAMP1 (14.28), PFN1 (14.28), ALS2CL (14.27), APCDD1 (14.27), DYNC1H1 (14.27), MYH14 (14.26), RPS21 (14.26), FAM129B (14.26), MAF (14.26), HNRNPDL (14.26), RXRA (14.24), FLNB (14.24), EEF2K (14.24), PDCD4 (14.24), TMBIM6 (14.24), HNRNPA1 (14.24), HNRNPU (14.23), PTGS1 (14.23), MAP4 (14.23), OGT (14.22), AES (14.22), CDH1 (14.22), JUNB (14.22), RPL41 (14.22), GAS6 (14.21), CTNNA1 (14.21), SFPQ (14.21), SPTAN1 (14.21), NBEAL2 (14.20), ZBTB7B (14.20), EMP1 (14.20), PLCH2 (14.20), SYNE2 (14.19), EIF5A (14.19), SH3D19 (14.19), FLG (14.18), IGFBP5 (14.18), STAT6 (14.18), FTH1 (14.18), KRT80 (14.18), CNBP (14.17), CCND1 (14.17), COL18A1 (14.16), RHOB (14.16), PLP2 (14.16), ERBB2 (14.16), ITPR3 (14.16), RPS7 (14.16), DDIT4 (14.16), SERF2 (14.16), PLXNB1 (14.16), FOSL2 (14.16), PRRC2B (14.16), COL1A1 (14.15), ATP2B4 (14.15), CHP2 (14.15), IQGAP1 (14.14), RPS29 (14.14), MATR3 (14.14), ADAM15 (14.14), MYL12B (14.14), CTNNBIP1 (14.14), COL6A1 (14.13), S100A11 (14.13), SERBP1 (14.13), NR1D1 (14.13), SF3B1 (14.12), RPL6 (14.12), FUS (14.12), ATF4 (14.11), ILF3 (14.11), RPL38 (14.11), NISCH (14.11), EGFR (14.11), CCNL2 (14.11), PLXNB2 (14.10), DYNLL1 (14.10), IL20RB (14.09), EGR1 (14.09), NPIPB5 (14.09), FTL (14.09), MKNK2 (14.09), H1F0 (14.09), SUN1 (14.09), TACC2 (14.08), SLC25A3 (14.08), NFE2L1 (14.08), PPDPF (14.08), VCP (14.08), CLSTN1 (14.08), POLR2A (14.08), SH3GLB2 (14.08), HDLBP (14.07), KIAA1522 (14.07), SDC4 (14.07), ITGB4 (14.07), PTRF (14.07), SRSF3 (14.06), GRN (14.06), PLEKHG5 (14.06), RBM39 (14.06), LOC102724428 (14.06), GUK1 (14.06), RAC1 (14.05), RPL22 (14.05), YWHAB (14.05), CALM1 (14.04), HK1 (14.04), TSPO (14.04), BICD2 (14.04), UBA1 (14.04), CAST (14.04), CELSR2 (14.03), NFE2L2 (14.03), POF1B (14.03), EIF4H (14.03)\n\nBased on this expression profile, predict the chronological age group of the individual.\n\nOptions: A. 30-39; B. 70-79; C. 50-59; D. 60-69; E. 40-49; F. 20-29", | |
| "answer": "A", | |
| "ground_truth_note": "Sample ID: GTEX-ZYT6-2326-SM-5GZY3; Actual age: 30-39" | |
| }, | |
| { | |
| "pool": "olink_age_pairwise", | |
| "display_name": "Olink Age / Pairwise", | |
| "domain": "proteomics", | |
| "lb_code": "LB-0299", | |
| "prompt": "The assay platform is Olink Explore 3072 proximity extension assay (PEA) plasma proteomics. Values are NPX (Normalized Protein eXpression, log2 scale). 2890 proteins measured across Cardiometabolic, Inflammation, Oncology, and Neurology panels.\n\nBased on their plasma proteome profiles, which individual is older?\n\nProtein measurements:\nTop-100 differentially abundant proteins out of 2890 measured (NPX): KIAA1549 (A: -1.06, B: -15.65, A much higher); TFAP2A (A: 2.68, B: -11.61, A much higher); LELP1 (A: 4.87, B: -6.64, A much higher); PARD3 (A: -7.08, B: 3.75, B much higher); MICB_MICA (A: 0.68, B: -9.84, A much higher); CSH1 (A: -8.52, B: 1.41, B much higher); AP2B1 (A: -0.06, B: -9.54, A much higher); MYL6B (A: -5.43, B: 3.81, B much higher); MYOM2 (A: 0.73, B: -7.89, A much higher); SERPINH1 (A: -7.94, B: 0.61, B much higher); SERPINB5 (A: -6.64, B: 1.84, B much higher); SPINT3 (A: 4.27, B: -4.16, A much higher); GABARAP (A: 1.36, B: -6.58, A much higher); FMR1 (A: -7.07, B: 0.52, B much higher); OSTN (A: 0.07, B: -7.48, A much higher); HTR1A (A: -0.53, B: -8.01, A much higher); FH (A: 0.45, B: -6.98, A much higher); MTDH (A: -0.02, B: -7.43, A much higher); RAD51 (A: 0.25, B: -7.14, A much higher); SCN2A (A: -0.53, B: 6.51, B much higher); CYP24A1 (A: 5.02, B: -1.92, A much higher); KRT17 (A: -7.40, B: -0.89, B much higher); PFDN6 (A: -1.19, B: -7.69, A much higher); SPRR1B (A: -4.65, B: 1.81, B much higher); TEX33 (A: 0.97, B: 7.38, B much higher); ADM (A: 0.45, B: -5.70, A much higher); IL18RAP (A: 5.14, B: -0.89, A much higher); PER3 (A: -6.95, B: -1.11, B much higher); TP73 (A: 0.42, B: -5.39, A much higher); DHODH (A: 0.66, B: 6.46, B much higher); RPS10 (A: 0.61, B: 6.29, B much higher); BLOC1S2 (A: -5.90, B: -0.33, B much higher); TMSB10 (A: 0.10, B: -5.45, A much higher); DNLZ (A: 1.76, B: -3.70, A much higher); FGF21 (A: 2.28, B: -3.11, A much higher); SORCS2 (A: 0.47, B: -4.85, A much higher); GTF2IRD1 (A: -1.93, B: 3.15, B much higher); PDP1 (A: -1.61, B: 3.43, B much higher); MCEE (A: 5.05, B: 0.06, A much higher); IL1RN (A: 3.99, B: -0.96, A much higher); PYY (A: 4.19, B: -0.70, A much higher); MN1 (A: -0.40, B: 4.43, B much higher); NPPB (A: 1.31, B: -3.48, A much higher); GIPR (A: -1.56, B: -6.30, A much higher); NPPC (A: -0.35, B: -5.08, A much higher); GCG (A: 3.39, B: -1.30, A much higher); EPN1 (A: 5.45, B: 0.78, A much higher); NPY (A: 1.21, B: -3.46, A much higher); HADH (A: 3.56, B: -1.11, A much higher); WASL (A: 4.12, B: -0.53, A much higher); VCPKMT (A: 3.77, B: -0.78, A much higher); CRYM (A: 3.25, B: -1.24, A much higher); ZPR1 (A: 3.54, B: -0.91, A much higher); TCP11 (A: -1.02, B: 3.42, B much higher); MAPT (A: -7.84, B: -3.45, B much higher); IL36G (A: 3.14, B: -1.23, A much higher); CHGA (A: 1.63, B: -2.73, A much higher); HS3ST3B1 (A: 0.43, B: -3.92, A much higher); GDF15 (A: 2.55, B: -1.76, A much higher); STAM (A: -0.72, B: 3.51, B much higher); PM20D1 (A: -3.34, B: 0.82, B much higher); IL3 (A: 1.32, B: -2.80, A much higher); ABO (A: 0.57, B: -3.46, A much higher); CCL21 (A: 0.45, B: -3.56, A much higher); GADD45B (A: 1.15, B: -2.85, A much higher); CSNK1D (A: -0.79, B: 3.14, B much higher); ADGRG1 (A: 1.90, B: -1.96, A much higher); MSLNL (A: -0.46, B: -4.32, A much higher); RSPO3 (A: 0.91, B: -2.94, A much higher); GP2 (A: 2.88, B: -0.94, A much higher); CHIT1 (A: 0.73, B: -3.09, A much higher); TGFBR1 (A: 0.40, B: -3.38, A much higher); IZUMO1 (A: -0.06, B: -3.82, A much higher); IGFL4 (A: 1.35, B: 5.09, B much higher); KIR2DS4 (A: -1.01, B: 2.72, B much higher); REG4 (A: 2.16, B: -1.57, A much higher); VSIG2 (A: 0.87, B: -2.80, A much higher); CLNS1A (A: 0.44, B: -3.22, A much higher); RRP15 (A: -4.73, B: -1.09, B much higher); PADI2 (A: 0.59, B: -3.02, A much higher); TMOD4 (A: 0.25, B: -3.36, A much higher); NAA80 (A: 1.98, B: -1.62, A much higher); FAM3D (A: 1.66, B: -1.94, A much higher); DUSP29 (A: -0.63, B: -4.17, A much higher); UROS (A: -0.72, B: -4.25, A much higher); PPY (A: 1.05, B: -2.47, A much higher); TOP2B (A: 0.40, B: -3.11, A much higher); MYBPC1 (A: 0.12, B: -3.36, A much higher); POMC (A: 1.54, B: -1.94, A much higher); IL13RA2 (A: 0.79, B: -2.68, A much higher); LY6D (A: 2.85, B: -0.61, A much higher); CD177 (A: -0.18, B: -3.64, A much higher); INSL3 (A: 2.94, B: -0.51, A much higher); APOL1 (A: -0.87, B: 2.56, B much higher); BST1 (A: 0.27, B: -3.16, A much higher); REG3A (A: 1.07, B: -2.35, A much higher); DNAJB1 (A: -0.03, B: -3.45, A much higher); KLK3 (A: 2.17, B: -1.21, A much higher); CCND2 (A: 0.33, B: -3.06, A much higher); TEX101 (A: 2.04, B: -1.30, A much higher)\n\nOptions: A. Patient-A B. Patient-B", | |
| "answer": "A", | |
| "ground_truth_note": "Patient-A: Sample_17, age 69; Patient-B: Sample_279, age 53" | |
| }, | |
| { | |
| "pool": "olink-pooled_age_multiclass", | |
| "display_name": "Olink Age / Multiclass", | |
| "domain": "proteomics", | |
| "lb_code": "LB-0074", | |
| "prompt": "Measurements were performed using Olink Explore 3072 proximity extension assay (PEA) plasma proteomics. Values are NPX (Normalized Protein eXpression, log2 scale). Top 396 consensus aging proteins selected by cross-clock frequency across Kuo, Goeminne, and Argentieri proteomic aging clocks.\n\nBased on the plasma proteome profile of consensus aging proteins, what is this individual's age decade?\n\nProtein measurements:\nProtein NPX: A1BG (-0.04); AAMDC (-0.59); AARSD1 (-0.55); ABHD14B (-0.74); ABL1 (-0.69); ABO (-4.50); ABRAXAS2 (-0.15); ACAA1 (1.92); ACADM (0.00); ACADSB (-0.23); ACE2 (0.83); ACHE (-0.20); ACOX1 (-0.77); ACP1 (-0.15); ACP5 (-0.04); ACP6 (-0.41); ACRBP (-0.18); ACRV1 (1.24); ACTA2 (-0.94); ACTN2 (-1.82); ACTN4 (-0.97); ACVRL1 (-0.69); ACY1 (1.56); ACYP1 (-0.31); ADA (0.09); ADA2 (-0.50); ADAM12 (-0.10); ADAM22 (-0.46); ADAM23 (-0.03); ADAM9 (-0.46); ADAMTS1 (-0.47); ADAMTS13 (-0.19); ADAMTS15 (-0.70); ADAMTS16 (-0.67); ADAMTS4 (0.58); ADAMTS8 (0.55); ADAMTSL2 (-0.44); ADAMTSL4 (-0.40); ADAMTSL5 (0.13); ADCYAP1R1 (0.43); ADD1 (-1.68); ADGRD1 (0.69); ADGRE1 (-0.85); ADGRE2 (-0.65); ADGRE5 (-0.43); ADGRF5 (-0.55); ADGRG1 (-0.33); ADGRG2 (-0.67); ADGRV1 (-7.26); ADH1B (2.05); ADH4 (1.69); ADM (-0.71); AFAP1 (-0.32); AFM (-0.16); AFP (-0.62); AGER (-0.37); AGR2 (-0.48); AGR3 (1.50); AGRN (-0.66); AGRP (-0.67); AGT (-0.30); AGXT (1.55); AHCY (0.17); AHNAK2 (-0.05); AHSA1 (0.26); AHSG (-0.68); AIDA (-2.04); AIF1 (-6.14); AIF1L (-0.42); AIFM1 (1.20); AK1 (-0.85); AK2 (-0.92); AKAP12 (-0.42); AKR1B1 (-0.46); AKR1B10 (0.80); ALPI (2.71); AMPD3 (-0.85); ANGPT2 (-0.62); APLP1 (-0.38); APOE (-0.43); AREG (-0.84); ART3 (-1.37); ATXN2 (-0.46); BAG3 (-0.24); BCAN (-0.45); BGLAP (0.13); BOC (-0.20); BRK1 (-0.21); BSG (-0.02); C19orf12 (1.12); C1QL2 (-0.74); CA14 (-0.70); CA2 (-0.57); CA4 (-0.78); CA6 (-1.35); CALB1 (-0.82); CALCA (1.32); CBLIF (-0.04); CCDC80 (-0.60); CCL17 (0.49); CCL24 (-0.49); CCL28 (-1.53); CCL5 (0.22); CCN5 (-1.01); CCNE1 (-0.94); CD177 (-1.54); CD1C (-0.15); CD248 (-0.73); CD8A (-0.82); CD93 (-0.43); CDCP1 (0.08); CDH2 (-0.07); CDH3 (-0.49); CDHR2 (2.44); CDON (0.11); CEACAM5 (-1.56); CEACAM6 (-0.77); CELA2A (-0.87); CELSR2 (-0.56); CHAD (-0.59); CHGB (-2.41); CHIT1 (-0.49); CHRDL1 (-0.84); CHRDL2 (0.00); CKAP4 (-0.51); CLEC14A (-0.81); CLEC4C (-0.73); CNDP1 (-0.73); CNTN5 (0.23); COL15A1 (-0.25); COL24A1 (-0.71); COL6A3 (-0.30); COL9A1 (-0.91); CPA2 (-0.92); CR2 (-0.60); CRH (-3.22); CRTAC1 (-0.49); CRYBB2 (-0.77); CSPG5 (-1.35); CSRP3 (0.80); CST5 (-0.80); CTHRC1 (-0.04); CTSF (0.31); CTSV (-0.12); CXADR (0.42); CXCL11 (-0.70); CXCL12 (-0.58); CXCL13 (-0.01); CXCL14 (-1.04); CXCL17 (-0.21); CXCL8 (-0.51); CXCL9 (-0.96); CYB5A (0.43); CYB5R2 (0.31); CYTL1 (-0.64); DCBLD2 (0.03); DCN (-0.35); DCTN2 (-0.52); DCXR (2.28); DDC (-0.11); DEFB4A_DEFB4B (-1.70); DIPK2B (-0.75); DKK3 (-0.66); DKKL1 (-0.39); DLK1 (0.20); DMP1 (-0.94); DNM1 (-0.26); DPEP2 (-0.50); DPT (-0.57); DSG4 (0.01); DUSP13 (-0.54); EDA2R (-1.36); EDAR (-0.01); EDDM3B (2.46); EDIL3 (-0.67); EFEMP1 (-1.02); EFHD1 (-0.42); EGFR (-0.17); ELN (-0.21); ENAH (-0.07); ENG (-0.12); ENO3 (-0.09); ENPP2 (-0.59); ENPP5 (-0.16); EPHA4 (-0.63); ERBB4 (-0.46); FABP2 (-0.55); FABP4 (-0.71); FABP6 (-0.07); FAM3B (-0.95); FAP (0.33); FAS (-0.58); FASLG (-0.93); FBLN2 (-0.48); FCRL1 (-0.23); FCRL2 (0.01); FCRLB (-0.38); FGF5 (-0.98); FGF7 (1.07); FGFBP1 (-0.15); FGFBP2 (-0.21); FLT3 (-0.62); FOLR3 (-4.75); FOXO3 (-0.05); FSHB (-1.50); FSTL1 (-0.46); FUCA1 (0.82); FUT3_FUT5 (-0.95); GALNT7 (-0.40); GAS6 (-0.19); GAST (-1.15); GCG (-1.58); GDF15 (-1.36); GFAP (-0.88); GFRAL (-1.70); GHRL (-2.97); GIPC2 (-0.04); GP2 (-0.84); GPA33 (0.07); GPIHBP1 (-0.65); GZMA (-0.36); HADH (0.10); HAO1 (2.61); HAVCR1 (-0.27); HGF (-0.45); HMCN2 (0.22); HPGDS (-0.99); HSD11B1 (-0.16); ICAM3 (-0.40); ICAM5 (0.14); IFNG (-0.98); IGDCC4 (-0.52); IGFBP3 (-1.10); IGFBP7 (-0.45); IL17D (-0.64); IL18RAP (2.90); IL1RL1 (-0.14); IL22 (-0.98); IL5RA (-0.71); IL6 (-0.94); IL7R (-0.46); INSL3 (6.92); ITGA2 (0.06); ITGAM (-0.38); ITGAV (-0.08); ITGB5 (-0.34); ITGBL1 (-1.19); IZUMO1 (2.12); KIF22 (-7.34); KIT (-0.65); KLK14 (-0.79); KLK3 (3.92); KLK4 (-0.87); KLK7 (0.09); KLK8 (0.02); KLRF1 (-0.41); KRT19 (-1.78); L1CAM (-0.23); LACRT (0.23); LCP1 (0.37); LECT2 (-0.30); LEG1 (-0.55); LHB (0.60); LMOD1 (-0.82); LPO (-0.09); LRRN1 (-0.07); LTBP2 (-0.56); LYPD3 (-0.04); MAMDC4 (0.95); MATN3 (-0.82); MEP1B (0.49); MEPE (-0.31); MERTK (-0.30); MET (-0.45); MFGE8 (-0.37); MICB_MICA (0.15); MLN (-1.28); MMP10 (-0.42); MMP12 (0.12); MMP9 (-0.46); MOG (-0.70); MSTN (-0.43); MXRA8 (0.78); NCAN (-0.02); NEFL (-1.68); NME3 (-0.37); NOTCH3 (-0.70); NPL (0.15); NPPB (-1.80); NPTN (-0.92); NPTX2 (-0.13); NTF3 (-1.01); NTF4 (-0.58); OCLN (0.05); ODAM (-0.07); OMG (-0.85); OPTC (-0.45); PAEP (0.05); PAMR1 (-0.20); PEPD (-0.19); PINLYP (-1.00); PKD1 (-0.46); PLA2G1B (-0.84); PLAT (0.27); PLB1 (-0.29); PM20D1 (2.09); PNLIPRP1 (-1.63); PNPT1 (-1.01); PODXL2 (-0.43); POMC (-0.78); PRELP (-0.72); PRG3 (-1.30); PRL (-0.80); PRND (0.63); PROK1 (-0.23); PRRT3 (-0.82); PRSS8 (0.31); PSCA (0.66); PSPN (3.01); PTGDS (-0.54); PTGR1 (1.29); PTN (-2.00); PTPRM (-0.01); PTPRN2 (-0.79); PTPRR (-0.71); PTPRZ1 (-0.66); RBFOX3 (-0.65); REG3G (-0.46); REN (-0.66); RET (0.53); RGMA (-0.54); RGMB (-0.55); RLN2 (-0.41); RNASE3 (-1.14); ROBO1 (-0.17); RRM2 (0.43); SCARF2 (-1.11); SCG2 (-0.61); SCG3 (-0.64); SCGB1A1 (-0.03); SCIN (-1.33); SDC4 (-0.42); SDK2 (-0.13); SELE (0.56); SELENOP (-0.41); SEPTIN3 (-1.91); SEZ6L (-0.57); SFRP1 (-0.01); SFTPA1 (0.02); SFTPD (-0.64); SHC1 (0.89); SKAP1 (-0.52); SLITRK2 (-0.57); SMPDL3A (0.58); SOD2 (-0.39); SORCS2 (-1.29); SOST (-0.53); SPINK1 (-1.26); SPOCK1 (0.07); SPON1 (-0.99); SPON2 (-0.62); SPP1 (-1.11); SPRR3 (-1.01); SRPX (-0.96); SSC4D (0.12); SUSD2 (-0.96); SUSD5 (-0.83); TCL1B (-0.45); TFF1 (-0.13); TGM2 (-0.08); THBS2 (-0.24); TNC (-0.73); TNFRSF10B (-0.64); TNFRSF11B (-0.67); TNFRSF13B (-0.34); TNFRSF6B (-0.20); TNFSF11 (0.02); TNFSF13 (-0.70); TNN (-0.45); TNR (-0.18); TNXB (-0.50); TPK1 (-0.36); TSPAN1 (-0.01); TSPAN8 (1.11); TTR (-0.62); TXNDC15 (-0.35); VGF (-0.68); WFDC2 (-0.92); WIF1 (-0.12); WNT9A (-0.64); XCL1 (-0.44); XG (-0.49); ZNRD2 (-0.69)\n\nOptions: A. 60-69 B. 40-49 C. 80-89 D. 70-79 E. 50-59", | |
| "answer": "E", | |
| "ground_truth_note": "Sample ID: KT03720; Actual age: 53" | |
| }, | |
| { | |
| "pool": "olink-pooled_age_regression", | |
| "display_name": "Olink Age / Regression", | |
| "domain": "proteomics", | |
| "lb_code": "LB-0082", | |
| "prompt": "The data was measured using Olink Explore 3072 proximity extension assay (PEA) plasma proteomics. Values are NPX (Normalized Protein eXpression, log2 scale). Top 396 consensus aging proteins selected by cross-clock frequency across Kuo, Goeminne, and Argentieri proteomic aging clocks.\n\nGiven the following plasma proteomics profile of consensus aging proteins, predict this individual's chronological age in years.\n\nProtein measurements:\nProtein NPX: A1BG (-0.04); AAMDC (-0.59); AARSD1 (-0.55); ABHD14B (-0.74); ABL1 (-0.69); ABO (-4.50); ABRAXAS2 (-0.15); ACAA1 (1.92); ACADM (0.00); ACADSB (-0.23); ACE2 (0.83); ACHE (-0.20); ACOX1 (-0.77); ACP1 (-0.15); ACP5 (-0.04); ACP6 (-0.41); ACRBP (-0.18); ACRV1 (1.24); ACTA2 (-0.94); ACTN2 (-1.82); ACTN4 (-0.97); ACVRL1 (-0.69); ACY1 (1.56); ACYP1 (-0.31); ADA (0.09); ADA2 (-0.50); ADAM12 (-0.10); ADAM22 (-0.46); ADAM23 (-0.03); ADAM9 (-0.46); ADAMTS1 (-0.47); ADAMTS13 (-0.19); ADAMTS15 (-0.70); ADAMTS16 (-0.67); ADAMTS4 (0.58); ADAMTS8 (0.55); ADAMTSL2 (-0.44); ADAMTSL4 (-0.40); ADAMTSL5 (0.13); ADCYAP1R1 (0.43); ADD1 (-1.68); ADGRD1 (0.69); ADGRE1 (-0.85); ADGRE2 (-0.65); ADGRE5 (-0.43); ADGRF5 (-0.55); ADGRG1 (-0.33); ADGRG2 (-0.67); ADGRV1 (-7.26); ADH1B (2.05); ADH4 (1.69); ADM (-0.71); AFAP1 (-0.32); AFM (-0.16); AFP (-0.62); AGER (-0.37); AGR2 (-0.48); AGR3 (1.50); AGRN (-0.66); AGRP (-0.67); AGT (-0.30); AGXT (1.55); AHCY (0.17); AHNAK2 (-0.05); AHSA1 (0.26); AHSG (-0.68); AIDA (-2.04); AIF1 (-6.14); AIF1L (-0.42); AIFM1 (1.20); AK1 (-0.85); AK2 (-0.92); AKAP12 (-0.42); AKR1B1 (-0.46); AKR1B10 (0.80); ALPI (2.71); AMPD3 (-0.85); ANGPT2 (-0.62); APLP1 (-0.38); APOE (-0.43); AREG (-0.84); ART3 (-1.37); ATXN2 (-0.46); BAG3 (-0.24); BCAN (-0.45); BGLAP (0.13); BOC (-0.20); BRK1 (-0.21); BSG (-0.02); C19orf12 (1.12); C1QL2 (-0.74); CA14 (-0.70); CA2 (-0.57); CA4 (-0.78); CA6 (-1.35); CALB1 (-0.82); CALCA (1.32); CBLIF (-0.04); CCDC80 (-0.60); CCL17 (0.49); CCL24 (-0.49); CCL28 (-1.53); CCL5 (0.22); CCN5 (-1.01); CCNE1 (-0.94); CD177 (-1.54); CD1C (-0.15); CD248 (-0.73); CD8A (-0.82); CD93 (-0.43); CDCP1 (0.08); CDH2 (-0.07); CDH3 (-0.49); CDHR2 (2.44); CDON (0.11); CEACAM5 (-1.56); CEACAM6 (-0.77); CELA2A (-0.87); CELSR2 (-0.56); CHAD (-0.59); CHGB (-2.41); CHIT1 (-0.49); CHRDL1 (-0.84); CHRDL2 (0.00); CKAP4 (-0.51); CLEC14A (-0.81); CLEC4C (-0.73); CNDP1 (-0.73); CNTN5 (0.23); COL15A1 (-0.25); COL24A1 (-0.71); COL6A3 (-0.30); COL9A1 (-0.91); CPA2 (-0.92); CR2 (-0.60); CRH (-3.22); CRTAC1 (-0.49); CRYBB2 (-0.77); CSPG5 (-1.35); CSRP3 (0.80); CST5 (-0.80); CTHRC1 (-0.04); CTSF (0.31); CTSV (-0.12); CXADR (0.42); CXCL11 (-0.70); CXCL12 (-0.58); CXCL13 (-0.01); CXCL14 (-1.04); CXCL17 (-0.21); CXCL8 (-0.51); CXCL9 (-0.96); CYB5A (0.43); CYB5R2 (0.31); CYTL1 (-0.64); DCBLD2 (0.03); DCN (-0.35); DCTN2 (-0.52); DCXR (2.28); DDC (-0.11); DEFB4A_DEFB4B (-1.70); DIPK2B (-0.75); DKK3 (-0.66); DKKL1 (-0.39); DLK1 (0.20); DMP1 (-0.94); DNM1 (-0.26); DPEP2 (-0.50); DPT (-0.57); DSG4 (0.01); DUSP13 (-0.54); EDA2R (-1.36); EDAR (-0.01); EDDM3B (2.46); EDIL3 (-0.67); EFEMP1 (-1.02); EFHD1 (-0.42); EGFR (-0.17); ELN (-0.21); ENAH (-0.07); ENG (-0.12); ENO3 (-0.09); ENPP2 (-0.59); ENPP5 (-0.16); EPHA4 (-0.63); ERBB4 (-0.46); FABP2 (-0.55); FABP4 (-0.71); FABP6 (-0.07); FAM3B (-0.95); FAP (0.33); FAS (-0.58); FASLG (-0.93); FBLN2 (-0.48); FCRL1 (-0.23); FCRL2 (0.01); FCRLB (-0.38); FGF5 (-0.98); FGF7 (1.07); FGFBP1 (-0.15); FGFBP2 (-0.21); FLT3 (-0.62); FOLR3 (-4.75); FOXO3 (-0.05); FSHB (-1.50); FSTL1 (-0.46); FUCA1 (0.82); FUT3_FUT5 (-0.95); GALNT7 (-0.40); GAS6 (-0.19); GAST (-1.15); GCG (-1.58); GDF15 (-1.36); GFAP (-0.88); GFRAL (-1.70); GHRL (-2.97); GIPC2 (-0.04); GP2 (-0.84); GPA33 (0.07); GPIHBP1 (-0.65); GZMA (-0.36); HADH (0.10); HAO1 (2.61); HAVCR1 (-0.27); HGF (-0.45); HMCN2 (0.22); HPGDS (-0.99); HSD11B1 (-0.16); ICAM3 (-0.40); ICAM5 (0.14); IFNG (-0.98); IGDCC4 (-0.52); IGFBP3 (-1.10); IGFBP7 (-0.45); IL17D (-0.64); IL18RAP (2.90); IL1RL1 (-0.14); IL22 (-0.98); IL5RA (-0.71); IL6 (-0.94); IL7R (-0.46); INSL3 (6.92); ITGA2 (0.06); ITGAM (-0.38); ITGAV (-0.08); ITGB5 (-0.34); ITGBL1 (-1.19); IZUMO1 (2.12); KIF22 (-7.34); KIT (-0.65); KLK14 (-0.79); KLK3 (3.92); KLK4 (-0.87); KLK7 (0.09); KLK8 (0.02); KLRF1 (-0.41); KRT19 (-1.78); L1CAM (-0.23); LACRT (0.23); LCP1 (0.37); LECT2 (-0.30); LEG1 (-0.55); LHB (0.60); LMOD1 (-0.82); LPO (-0.09); LRRN1 (-0.07); LTBP2 (-0.56); LYPD3 (-0.04); MAMDC4 (0.95); MATN3 (-0.82); MEP1B (0.49); MEPE (-0.31); MERTK (-0.30); MET (-0.45); MFGE8 (-0.37); MICB_MICA (0.15); MLN (-1.28); MMP10 (-0.42); MMP12 (0.12); MMP9 (-0.46); MOG (-0.70); MSTN (-0.43); MXRA8 (0.78); NCAN (-0.02); NEFL (-1.68); NME3 (-0.37); NOTCH3 (-0.70); NPL (0.15); NPPB (-1.80); NPTN (-0.92); NPTX2 (-0.13); NTF3 (-1.01); NTF4 (-0.58); OCLN (0.05); ODAM (-0.07); OMG (-0.85); OPTC (-0.45); PAEP (0.05); PAMR1 (-0.20); PEPD (-0.19); PINLYP (-1.00); PKD1 (-0.46); PLA2G1B (-0.84); PLAT (0.27); PLB1 (-0.29); PM20D1 (2.09); PNLIPRP1 (-1.63); PNPT1 (-1.01); PODXL2 (-0.43); POMC (-0.78); PRELP (-0.72); PRG3 (-1.30); PRL (-0.80); PRND (0.63); PROK1 (-0.23); PRRT3 (-0.82); PRSS8 (0.31); PSCA (0.66); PSPN (3.01); PTGDS (-0.54); PTGR1 (1.29); PTN (-2.00); PTPRM (-0.01); PTPRN2 (-0.79); PTPRR (-0.71); PTPRZ1 (-0.66); RBFOX3 (-0.65); REG3G (-0.46); REN (-0.66); RET (0.53); RGMA (-0.54); RGMB (-0.55); RLN2 (-0.41); RNASE3 (-1.14); ROBO1 (-0.17); RRM2 (0.43); SCARF2 (-1.11); SCG2 (-0.61); SCG3 (-0.64); SCGB1A1 (-0.03); SCIN (-1.33); SDC4 (-0.42); SDK2 (-0.13); SELE (0.56); SELENOP (-0.41); SEPTIN3 (-1.91); SEZ6L (-0.57); SFRP1 (-0.01); SFTPA1 (0.02); SFTPD (-0.64); SHC1 (0.89); SKAP1 (-0.52); SLITRK2 (-0.57); SMPDL3A (0.58); SOD2 (-0.39); SORCS2 (-1.29); SOST (-0.53); SPINK1 (-1.26); SPOCK1 (0.07); SPON1 (-0.99); SPON2 (-0.62); SPP1 (-1.11); SPRR3 (-1.01); SRPX (-0.96); SSC4D (0.12); SUSD2 (-0.96); SUSD5 (-0.83); TCL1B (-0.45); TFF1 (-0.13); TGM2 (-0.08); THBS2 (-0.24); TNC (-0.73); TNFRSF10B (-0.64); TNFRSF11B (-0.67); TNFRSF13B (-0.34); TNFRSF6B (-0.20); TNFSF11 (0.02); TNFSF13 (-0.70); TNN (-0.45); TNR (-0.18); TNXB (-0.50); TPK1 (-0.36); TSPAN1 (-0.01); TSPAN8 (1.11); TTR (-0.62); TXNDC15 (-0.35); VGF (-0.68); WFDC2 (-0.92); WIF1 (-0.12); WNT9A (-0.64); XCL1 (-0.44); XG (-0.49); ZNRD2 (-0.69)", | |
| "answer": "53", | |
| "ground_truth_note": "Sample ID: KT03720; Actual age: 53" | |
| }, | |
| { | |
| "pool": "opengenes_expression_binary", | |
| "display_name": "OpenGenes / Binary", | |
| "domain": "genetics", | |
| "lb_code": "LB-0086", | |
| "prompt": "Model organism data:\nNo model organism data available for this gene.\n\nProtein-protein interactions:\nThis gene interacts with MDH2, KYAT3, TAT, GOT1, SDHA, KYAT1, GLUD1, FH, GPT, GPT2, ASNS, LDHAL6B, LDHA, LDHAL6A, LDHC, HPD, GLUD2, GOT1L1, IDH2, FABP1, TST, MPST, FABP2, ALDH4A1, and CS, and 56 other proteins in humans.\n\nGO term annotations:\nThis gene has molecular functions including L-aspartate:2-oxoglutarate aminotransferase activity, transaminase activity, catalytic activity, kynurenine-oxoglutarate transaminase activity, and transferase activity; participates in malate-aspartate shuttle, lipid transport, trans-4-hydroxy-L-proline catabolic process, response to ethanol, and 2-oxoglutarate metabolic process; is located in plasma membrane, mitochondrion, mitochondrial matrix, and extracellular exosome.\n\nTissue expression data:\nThis gene mRNA (Tau=0.85, tissue-enhanced) is most expressed in skeletal muscle, heart muscle, and liver (nTPM 218-379). High mRNA expression also in retina, cerebral cortex, adrenal gland, kidney, esophagus, cerebellum, hypothalamus, stomach, hippocampal formation, midbrain, urinary bladder, colon, basal ganglia, salivary gland, pituitary gland, prostate, spinal cord, vagina, amygdala, skin, cervix, endometrium, thyroid gland, small intestine, pancreas, fallopian tube, blood vessel, ovary, testis, spleen, breast, lung, and adipose tissue (nTPM 19-85). High protein expression in Cerebellum, Epididymis, Heart muscle, Seminal vesicle, Urinary bladder, Kidney (mixed), Lymph node (mixed), Ovary (mixed), and Tonsil (mixed). Medium in Adrenal gland, Appendix, Colon, Duodenum, Esophagus, Gallbladder, Pancreas, Parathyroid gland, Prostate, Rectum, Small intestine, Stomach, Thyroid gland, Breast (mixed), Bronchus (mixed), Cervix (mixed), Fallopian tube (mixed), Nasopharynx (mixed), and Testis (mixed). Low in Oral mucosa, Placenta, Salivary gland, Skeletal muscle, Caudate (mixed), Cerebral cortex (mixed), Endometrium (mixed), Hippocampus (mixed), Liver (mixed), Lung (mixed), Skin (mixed), Soft tissue (mixed), and Spleen (mixed). Not detected in Adipose tissue, Bone marrow, Smooth muscle, and Vagina.\n\nIn muscle of humans between ages 18 and 65 years, Gene X mRNA expression measured by microarray:\n\nOptions: A. decreases with age B. increases with age", | |
| "answer": "A", | |
| "ground_truth_note": "Gene: GOT2. GOT2 showed decreased gene expression by 20.0% in muscle between ages 18 and 65 years, measured by microarray. DOI: 10.1371/journal.pone.0000465" | |
| }, | |
| { | |
| "pool": "synergyage_lifespan_pairwise_ablated", | |
| "display_name": "SynergyAge / Pairwise", | |
| "domain": "genetics", | |
| "lb_code": "LB-0122", | |
| "prompt": "Which intervention results in longer mean lifespan?\n\nOptions: A. p38a(df);p38b(df) B. p38a(df)\n\nSpecies: Drosophila melanogaster\n\nPreviously observed effects:\np38a(df): -30.6% lifespan (34 days vs 49 days WT) | p38b(df): -61.2%, +38.8%. Mean: -11.2% (43 days vs 49 days WT)", | |
| "answer": "B", | |
| "ground_truth_note": "Reference answer: B" | |
| }, | |
| { | |
| "pool": "synergyage_lifespan_regression", | |
| "display_name": "SynergyAge / Regression", | |
| "domain": "genetics", | |
| "lb_code": "LB-0126", | |
| "prompt": "What is the percent lifespan change of p38a(df);p38b(df) compared to wild type? Answer as a signed percentage.\n\nOrganism: Drosophila melanogaster\n\nThe genes of interest are:\np38b: p38b (p38b MAP kinase) | p38a: p38a (p38a MAP kinase)\n\nGO term annotations:\np38b: Function: protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, ATP binding, transferase activity, +3 more | Process: heart morphogenesis, regulation of innate immune response, cellular response to cadmium ion, regulation of cellular response to oxidative stress, MAPK cascade, +27 more | Location: cytoplasm, nucleus | p38a: Function: protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, ATP binding, transferase activity, +3 more | Process: heart morphogenesis, negative regulation of antimicrobial humoral response, cellular response to cadmium ion, regulation of cellular response to oxidative stress, MAPK cascade, +20 more | Location: cytoplasm, nucleus\n\nExperimental details:\nTemperature: 25°C Diet: Standard Drosophila culture medium Drosophila were reared in standard culture media at 25°C.10–20 female or male flies were housed in vials containing standard Drosophila culture medium and transferred to fresh vials every 2–3 days as needed. The number of dead animals was determined daily.\n\nKnown individual effects:\np38a(df): -30.6% lifespan (34 days vs 49 days WT) | p38b(df): -61.2%, +38.8%. Mean: -11.2% (43 days vs 49 days WT)", | |
| "answer": "-93.9%", | |
| "ground_truth_note": "p38a(df): 34 days (-30.6% vs 49 WT) [PMID:22014527] | p38b(df): 43 days (-11.2% vs 49 WT) [PMID:22014527] (N=2, range: 19.0–68.0 days) | p38a(df);p38b(df): 3 days (-93.9% vs 49 WT) [PMID:22014527] | Interaction: Synergistic (negative)" | |
| } | |
| ] |
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