---
license: apache-2.0
tags:
- protein-design
- protein-binder-design
- generative-model
- flow-matching
- structure-generation
- bioinformatics
- computational-biology
- protein-engineering
---

# Model Card for Chamaileon

Chamaileon is a generative framework for **cross-context protein binder design**. It is designed to generate a **single binder sequence** that can bind to multiple protein contexts.

Unlike conventional binder design methods that typically assume a single target and a single structural state, Chamaileon formulates binder generation as **cross-context binding landscape modeling**. This enables the model to address challenging design scenarios such as:

- **Multi-state binder design**, where one binder must remain compatible with multiple conformational states of a target protein.
- **Multi-target binder design**, where one binder sequence is optimized to bind multiple related target interfaces.

The official code repository is available at:

https://github.com/caohengyuan/Chamaileon