Drug,Description
DB09000,"Cyamemazine (Tercian), also known as cyamepromazine,"
DB06261,In vitro studies have shown increased porphyrin fluorescence in normal urothelium after exposure to hexaminolevulinate hydrochloride intravesical solution.
DB00511,The main pharmacological effects of acetyldigitoxin are on the heart.
DB00821,"Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen."
DB00564,**General effects**Carbamazepine treats seizures and the symptoms of trigeminal neuralgia by inhibiting sodium channels.
DB01174,"Phenobarbital, the longest-acting barbiturate,"
DB00972,"Azelastine antagonizes the actions of histamine,"
DB00812,"Phenylbutazone is a synthetic, pyrazolone derivative."
DB05676,"Apremilast reduces but does not completely inhibit various inflammatory cytokines such as IL-1α, IL-6, IL-8, IL-10 MCP-1, MIP-1β, MMP-3, and TNF-α,"
DB04951,"Pirfenidone is a novel agent with anti-inflammatory, antioxidant, and antifibrotic properties."
DB01283,Lumiracoxib has a different structure from the standard COX-2 inhibitors.
DB00254,Doxycycline and other tetracyclines are mainly bacteriostatic and are thought to exert antimicrobial effects by the inhibition of protein synthesis
DB00374,"As an analogue of prostacyclin, treprostinil promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation ."
DB00784,"Mefenamic acid, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs)."
DB01254,Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor
DB08991,Epirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain
DB01250,Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.
DB02709,"Resveratrol, a phytoalexin, has been found to inhibit herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) replication in a dose-dependent,"
DB00795,"The mode of action of sulfasalazine or its metabolites,"
DB01097,Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA).
DB00469,"Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties,"
DB08814,Triflusal is an antithrombotic anticoagulant.
DB00261,Anagrelide decreases platelet counts by suppressing transcription factors necessary for the synthesis and maturation of platelet-producing cells
DB01050,Ibuprofen has multiple actions in different inflammatory pathways involved in acute and chronic inflammation.
DB00586,Diclofenac reduces inflammation and by extension reduces nociceptive pain and combats fever
DB01401,Trisalicylate-choline is a non-steroidal anti-inflammatory drug (NSAID) that contains a combination of choline salicylate and magnesium salicylate.
DB09212,"Loxoprofen is a non-selective inhibitor of cyclooxygenase enzymes, which are responsible for the formation of various biologically active pain, fever, and inflammatory mediators."
DB08880,"Teriflunomide is an immunomodulatory agent that decreases the amount of activated CNS lymphocytes,"
DB08984,Etofenamate is used to treat muscle and joint paint.
DB09070,"Tibolone prevents bone loss and treating post-menopausal symptoms without stimulating the endometrial tissues, which may lead to malignancy."
DB08981,"Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis."
DB01240,"Epoprostenol has two major pharmacological actions: (1) direct vasodilation of pulmonary and systemic arterial vascular beds, and (2) inhibition of platelet aggregation."
DB00619,Imatinib is a 2-phenylaminopyrimidine derivative neoplastic agent that belongs to the class of tyrosine kinase inhibitors.
DB09074,Olaparib is a cytotoxic and anti-tumour agent.
DB00246,"Ziprasidone is classified as a ""second generation"" or ""atypical"" antipsychotic and is a dopamine and 5HT2A receptor antagonist with a unique receptor binding profile."
DB05521,Telaprevir is classified as a direct-acting antiviral (DAA) and prevents viral replication in HCV genotype 1 
DB00289,Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD)
DB09054,"Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL),"
DB08873,Boceprevir is classified as a direct-acting antiviral (DAA) and prevents viral replication in HCV genotype 1 
DB04573,Estriol (also oestriol) is one of the three main estrogens produced by the human body
DB08912,Dabrafenib is a kinase inhibitor that is mainly used to target BRAF V600E mutation in multiple types of cancer.
DB02703,Fusidic acid is a bacteriostatic antibiotic and helps prevent bacterial growth while the immune system clears the infection
DB00378,"Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus."
DB09124,Medrogestone was created as a more potent and orally active option of progesterone.
DB01609,Deferasirox is an orally active chelator that is selective for iron (as Fe3+).
DB00607,Nafcillin is a semisynthetic antibiotic substance derived from 6-amino-penicillanic acid
DB00238,Nevirapine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
DB01351,A barbiturate with hypnotic and sedative properties (but not antianxiety).
DB00451,"Oral levothyroxine is a synthetic hormone that exerts the same physiologic effect as endogenous T<sub>4</sub>,"
DB00279,"In hormonal replacement,"
DB00675,Tamoxifen is a selective estrogen receptor modulator that inhibits growth and promotes apoptosis in estrogen receptor positive tumors
DB06739,Seratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma
DB09218,Clonixin is a non-steroidal anti-inflammatory drug (NSAID) similar in structure to .
DB00749,Etodolac is an anti-inflammatory agent with analgesic and antipyretic properties.
DB01076,Atorvastatin is an oral antilipemic agent that reversibly inhibits HMG-CoA reductase.
DB09030,Vorapaxar is a tricyclic himbacine-deriv
DB00370,**General effects and a note on suicidality**Mirtazapine is effective in treating moderate to severe depression and treats many symptoms normally associated with this condition.
DB00569,"Fondaparinux binds specifically to the natural anticoagulant factor, ATIII."
DB08976,Floctafenine is an anti-inflammatory analgesic similar in action to aspirin.
DB00775,"Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack,"
DB04552,"Niflumic acid, a nonsteroidal anti-inflammatory fenamate,"
DB08994,Ditazole is a non-steroidal anti-inflammatory drug (NSAID).
DB04918,"Ceftobiprole, a cephalosporin antibiotic,"
DB08887,Icosapent ethyl or ethyl eicosapentaenoic acid is a synthetic derivative of the omega-3 fatty acid eicosapentaenoic acid (EPA)
DB01166,"Cilostazol reduces the symptoms of intermittent claudication, as indicated by an increased walking distance."
DB00417,Phenoxymethylpenicillin works against penicillin-sensitive microorganisms with bactericidal effects.
DB12598,Nafamostat is a fast-acting proteolytic inhibitor used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin by competitively inhibiting several serine proteases including thrombin
DB09075,"Administration of edoxaban results in prolongation of clotting time tests such as aPTT (activated partial thromboplastin time), PT (prothrombin time),"
DB00498,Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver
DB09288,Propacetamol is hydrolyzed to paracetamol and then it presents a weak inhibition of COX-1 and COX-2 which is translated into a low anti-inflammatory activity.
DB01420,The administration of testosterone propionate can induce production of proteins related to male sexual development.
DB01416,"Cefpodoxime is shown to be effective against most Gram positive and Gram negative bacteria, except <i>Pseudomonas aeruginosa</i>, <i>Enterococcus</i>,"
DB00244,"Mesalazine is one of the two components of sulphasalazine, the other being sulphapyridine."
DB00482,"Celecoxib inhibits cyclooxygenase 2 (COX-2) enzyme, reducing pain and inflammation."
DB00758,Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke
DB06725,Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the oxicam class.
DB00344,Protriptyline is a tricyclic antidepressant.
DB00163,"Vitamin E is a collective term used to describe 8 separate fat soluble antioxidants, most commonly alpha-tocopherol."
DB09093,Tetracycline antibiotics are bacteriostatic agents which act to inhibit bacterial growth and reproduction 
DB00540,Nortriptyline exerts antidepressant effects likely by inhibiting the reuptake of serotonin and norepinephrine at neuronal cell membranes.
DB00618,"Demeclocycline is a tetracycline antibiotic active against the following microorganisms: <i>Rickettsiae</i> (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox, tick fevers),"
DB01142,"Similar to other tricyclic antidepressants, doxepin was shown, in preclinical trials,"
DB01329,Cefoperazone is a third generation cephalosporin antibiotic
DB00685,Trovafloxacin is a broad spectrum antibiotic that inhibits DNA supercoiling in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV
DB01155,Gemifloxacin is a quinolone/fluoroquinolone antibiotic.
DB01332,Ceftizoxime is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms
DB01333,A semi-synthetic cephalosporin antibiotic.
DB00215,Citalopram belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs).
DB00458,Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin.
DB09320,It is an antibiotic against penicillin-susceptible microorganisms with bactericidal effect.
DB09323,Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria
DB00839,Tolazamide is an oral blood glucose lowering drug of the sulfonylurea class.
DB08983,Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin.
DB00715,"Paroxetine treats the symptoms of depression, various anxiety disorders, posttraumatic stress disorder, obsessive-compulsive disorder,"
DB01149,"Nefazodone, an antidepressant synthetically derived phenylpiperazine, is used to treat major depression."
DB06710,Testosterone is a steroid hormone from the androgen group.
DB00539,Toremifene is an antineoplastic hormonal agent primarily used in the treatment of advanced breast cancer.
DB01120,"Based on the pharmacological properties,"
DB00263,Sulfisoxazole is a sulfonamide antibiotic.
DB09270,"Ubidecarenon has roles in many prysiological process including sulfide oxidation,"
DB00285,Venlafaxine is an antidepressant agent that works to ameliorate the symptoms of various psychiatric disorders by increasing the level of neurotransmitters in the synapse.
DB01132,"Pioglitazone enhances cellular responsiveness to insulin, increases insulin-dependent glucose disposal, and improves impaired glucose homeostasis."
DB08865,"In a phase I study, 37 patients with a variety of solid-tumor cancers refractory to therapy received 50 to 300 mg of crizotinib daily or twice daily."
DB00648,Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types
DB01167,Itraconazole is an imidazole/triazole type antifungal agent.
DB00257,Clotrimazole is a broad-spectrum antifungal agent that inhibits the growth of pathogenic yeasts by changing the permeability of cell membranes
DB00243,Ranolazine exerts both antianginal and ischemic effects independent from lowering heart rate or blood pressure.
DB06595,"It targets multiple WT and mutated kinases that, when activated,"
DB01264,"Darunavir is an inhibitor of the human immunodeficiency virus (HIV) protease, which prevents HIV viral replication."
DB00270,Isradipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels
DB09065,"Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV)."
DB00622,"Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris,"
DB01232,Saquinavir exerts its antiviral activity by inhibiting an enzyme critical for the HIV-1 viral lifecycle.
DB01357,The 3-methyl ether of ethinyl estradiol.
DB01033,Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias
DB01259,Lapatinib is a small molecule and a member of the 4-anilinoquinazoline class of kinase inhibitors.
DB01023,"Felodipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs),"
DB01029,Irbesartan is an angiotensin receptor blocker used to treat hypertension and diabetic nephropathy
DB00422,Methylphenidate is a racemic mixture comprised of the d- and l-isomers.
DB06290,"Simeprevir is a direct-acting antiviral agent and inhibitor for HCV NS3/4A protease, which is an important enzyme required for viral replication."
DB00549,"Zafirlukast is a synthetic,"
DB01128,Bicalutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer.
DB00717,Norethisterone is a synthetic oral progestin used for contraception or to treat other hormone-related conditions such as menopausal symptoms and endometriosis.
DB04911,"Oritavancin interferes with bacterial cell wall synthesis and integrity, treating susceptible skin and subcutaneous tissue infections with gram-positive bacteria."
DB09330,A pharmacokinetic/pharmacodynamic analysis suggested a concentration-dependent QTc interval prolongation of 14 msec (upper bound of two-sided 90% CI: 16 msec) at a dose of osimertinib 80 mg
DB00688,Mycophenolate mofetil is a prodrug of mycophenolic acid (MPA).
DB00814,"Meloxicam is an anti-inflammatory, analgesic analgesic with antipyretic effects in fever."
DB00963,"Bromfenac ophthalmic solution is a sterile, topical,"
DB06802,"Low but quantifiable plasma concentrations of nepafenac and amfenac were observed in the majority of subjects 2 and 3 hours postdose,"
DB00179,Masoprocol is a novel antineoplastic agent.
DB09215,Droxicam is a prodrug of .
DB00712,"Flurbiprofen, a nonsteroidal anti-inflammatory agent (NSAIA) of the propionic acid class, is structually and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen,"
DB00465,Ketorolac is a non-selective NSAID and acts by inhibiting both COX-1 and COX-2 enzymes which are normally responsible for converting arachidonic acid to prostaglandins
DB01397,Magnesium salicylate is a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain.
DB09123,"Dienogest exhibits a very potent progestagenic effect in the endometrium,"
DB00603,"Medroxyprogesterone acetate (MPA) inhibits gonadotropin production, reduces nuclear estrogen receptors and DNA synthesis in epithelial cells of the endometrium,"
DB06789,No specific pharmacodynamic studies have been performed to assess hydroxyprogesterone caproate injections.
DB11636,Nomegestrol is an ingredient in the EMA-authorised product Zoely
DB01600,"Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain."
DB00233,Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli
DB00573,"Fenoprofen is a propionic acid derivative with analgesic, antiinflammatory and antipyretic properties."
DB00744,Zileuton is an asthma drug that differs chemically and pharmacologically from other antiasthmatic agents.
DB04743,"Food,"
DB01236,Sevoflurane induces muscle relaxation and reduces sensitivity by altering tissue excitability with a fast onset of action
DB00768,Inflammatory reactions in response to various stimuli are mediated by endogenous mediators and other pro-inflammatory factors
DB00932,Tipranavir is a non-peptidic protease inhibitor (PI) of HIV.
DB01009,Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
DB00554,Piroxicam is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).
DB00939,"Meclofenamic acid is a nonsteroidal agent which has demonstrated anti-inflammatory, analgesic,"
DB00991,Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.
DB06730,Gestodene is a progestogen hormonal contraceptive.
DB00691,Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat.
DB00722,"Lisinopril is an angiotensin converting enzyme inhibitor used to treat hypertension, heart failure, and myocardial infarction."
DB00584,Enalapril is an antihypertensive agent that exhibits natriuretic and uricosuric properties.
DB00876,"Angiotensin II, the principal pressor agent of the renin-angiotensin system,"
DB01197,"Captopril, an ACE inhibitor, antagonizes the effect of the RAAS."
DB00492,"Following oral administration, fosinopril is rapidly and completely hydrolyzed to its principle active metabolite, fosinoprilat."
DB00396,"Progesterone, depending on concentration and dosage form, and timing of exposure may have several pharmacodynamic effects."
DB12364,Betrixaban is an oral anticoagulant that excerts its action by preventing thrombin generation without having a direct effect on platelet aggregation 
DB00615,Rifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells.
DB01320,Fosphenytoin is a water-soluble phenytoin prodrug used for the treatment of epileptic seizures.
DB01201,Rifapentine is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells.
DB05266,Ibudilast is an anti-inflammatory and ne
DB01399,Salsalate is a nonsteroidal anti-inflammatory agent for oral administration.
DB06737,A non-steroidal anti-inflammatory drug approved for use in Japan in 1993
DB00975,"Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin,"
DB00946,"Phenprocoumon, a coumarin anticoagulant,"
DB09216,Studies have shown that tolfenamic acid presents a non-dose dependent partial inhibition of irritant-induced temperature rise as well as a dose-dependent inhibition of skin edema
DB00210,"Adapalene is anticomedogenic, preventing the formation of new comedones and inflammatory lesions, and also acts to reduce inflammation by modulating the innate immune response."
DB00337,Pimecrolimus is a chemical that is used to treat atopic dermatitis (eczema).
DB00861,"Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties."
DB00266,Dicumarol is an coumarin-like compound found in sweet clover
DB04272,A key intermediate in metabolism.
DB01418,Acenocoumarol inhibits the reduction of vitamin K by vitamin K reductase.
DB00220,Nelfinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
DB00582,Voriconazole is a fungistatic triazole antifungal used to treat infections by inhibiting fungal growth.
DB12332,Rucaparib is an anticancer agent that exerts cytotoxic effects against cancer cells.
DB01211,"Clarithromycin is a macrolide antibiotic whose spectrum of activity includes many gram-positive <i>Staphylococcus aureus,"
DB00188,"Bortezomib works to target the ubiquitin-proteasome pathway, an essential molecular pathway that regulates intracellular concentrations of proteins and promotes protein degradation."
DB09118,Stiripentol is an antiepileptic agent that works to reduce seizure frequency.
DB08820,The use of Ivacaftor has been shown to both improve CF symptoms and modulate underlying disease pathology
DB00278,Argatroban is a synthetic direct thrombin inhibitor derived from L-arginine indicated as an anticoagulant for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia
DB00870,Suprofen is a non-steroidal anti-inflammatory analgesic and antipyretic.
DB09543,"Methyl salicylate relieve musculoskeletal pain in the muscles, joints,"
DB06605,"Apixaban selectively inhibits factor Xa in its free and bound forms, independant of antithrombin III."
DB00328,"Indometacin is an NSAID with analgesic and antipyretic properties that exerts its pharmacological effects by inhibiting the synthesis of factors involved in pain, fever,"
DB09084,Benzydamine is a non-steroidal anti-inflammatory drug (NSAID) designed to elicit local anesthetic and analgesic effects mainly for the mouth and throat
DB00461,"NSAIDs, like nabumetone, are well established as analgesics."
DB00255,Diethylstilbestrol is a synthetic estrogen that was developed to supplement a woman's natural estrogen production.
DB00977,"Ethinylestradiol is a synthetic estrogen that decreases luteinizing hormone to decrease endometrial vascularization,"
DB09211,Limaprost produces vasodilation to improve blood flow to the extremities and increase cutaneous temperature 
DB08954,"N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family,"
DB07615,Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals.
DB00945,**Effects on pain and fever**Acetylsalicylic acid disrupts the production of prostaglandins throughout the body by targeting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) .
DB00806,"Pentoxifylline, a synthetic dimethylxanthine derivative structurally related to and , exhibits hemorheological, anti-oxidative,"
DB08797,"Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl."
DB00735,"Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative."
DB09053,In vitro studies have shown an induction of CLL cell apoptosis even in presence of prosurvival factors
DB01171,"A selective, reversible inhibitor of monoamine oxidase (MAO) which increases the ."
DB00908,"Quinidine is an antimalarial schizonticide, and a class Ia antiarrhythmic agent used to interrupt or prevent reentrant arrhythmias and arrhythmias due to increased automaticity, such as atrial flutter,"
DB00375,"Cholesterol is the major, and probably the sole precursor of bile acids ."
DB00415,"Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
DB00794,"Primidone alters sodium and calcium channel transport, reducing the frequency of nerve firing,"
DB00673,"Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which,"
DB01220,"Rifaximin is a structural analog of rifampin and a non-systemic, gastrointestinal site-specific antibiotic."
DB00559,Bosentan belongs to a class of drugs known as endothelin receptor antagonists (ERAs).
DB01208,Sparfloxacin is a synthetic fluoroquinolone broad-spectrum antimicrobial agent in the same class as ofloxacin and norfloxacin.
DB00923,Ceforanide is a semisynthetic second-generation cephalosporin.
DB01098,"Rosuvastatin is a synthetic, enantiomerically pure antilipemic agent."
DB01039,"Fenofibrate is a fibrate that activates peroxisome proliferator activated receptor alpha (PPARα) to alter lipid metabolism and treat primary hypercholesterolemia, mixed dyslipidemia,"
DB08795,Azidocillin is a penicillin antibiotic similir to ampicillin
DB08804,Nandrolone decanoate is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis
DB11362,"At the maximum tolerated dose of 1600 mcg twice per day,"
DB01000,"Cyclacillin, a penicillin, is a cyclohexylamido analog of penicillanic acid."
DB01059,Norfloxacin is a quinolone/fluoroquinolone antibiotic.
DB00754,Ethotoin is a hydantoin derivative and anticonvulsant.
DB00605,"Sulindac is a non-steroidal anti-inflammatory indene derivative,"
DB08439,Parecoxib is a water-soluble and injectable prodrug of valdecoxib.
DB00602,"Ivermectin is a semisynthetic, anthelminitic agent."
DB00472,"Fluoxetine blocks the serotonin reuptake transporter in the presynaptic terminal, which ultimately results in sustained levels of 5-hydroxytryptamine (5-HT) in certain brain areas."
DB01016,"Glyburide is a second generation sulfonylurea that stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells,"
DB01131,Proguanil is a biguanide derivative that is converted to an active metabolite called cycloguanil.
DB00543,"Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class, chemically distinct from the dibenzodiazepines, dibenzocycloheptenes, and dibenzoxepines."
DB00359,Sulfadiazine is a sulfonamide antibiotic.
DB00591,"Fluocinolone acetonide is a synthetic anti-inflammatory corticosteroid and thus, the effect of its interaction with the body produces vasoconstriction and suppression of membrane permeability,"
DB01212,"Ceftriaxone is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms."
DB01242,"Clomipramine, a tricyclic antidepressant,"
DB08906,"Systemically, in vitro experiments show fluticasone furoate activates glucocorticoid receptors, inhibits nuclear factor kappa b,"
DB09008,Cephaloridine or cefaloridine is a first generation semisynthetic cephalosporin.
DB04576,Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone.
DB00873,This compound belongs to the class of organic compounds known as androgens and derivatives.
DB01137,Levofloxacin is bactericidal and exerts its antimicrobial effects via inhibition of bacterial DNA replication
DB00240,Alclometasone is a synthetic corticosteroid for topical dermatologic use.
DB01104,"Sertraline improves or relieves the symptoms of depression, OCD, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder,"
DB00253,Medrysone is a topical anti-inflammatory corticoidsteroids for ophthalmic use.
DB00635,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
DB01222,Budesonide is a glucocorticoid used to treat respiratory and digestive conditions by reducing inflammation.
DB06700,Desvenlafaxine is a selective serotonin and norepinephrine reuptake inhibitor.
DB01263,Posaconazole is an antifungal agent structurally related to itraconazole.
DB00304,"The effects of desogestrel are divided on reproductive including modification of luteinizing hormone and follicle stimulating hormone,"
DB01072,Atazanavir (ATV) is an azapeptide HIV-1 protease inhibitor (PI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1)
DB00268,"**Effects on Parkinson's and restless leg syndrome**This drug promotes the relief or improvement of symptoms of Parkinson's or restless leg syndrome by stimulatory actions on dopamine receptors,"
DB00301,"Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
DB00294,Etonogestrel attains its therapeutic effect inhibiting fertility by impairing the release of the luteinizing hormone which is one of the most important reproductive hormones for ovulation.
DB09119,Eslicarbazepine acetate is associated with a dose- and concentration-dependant increase in heart rate and prolongation of PR interval
DB08933,"Luliconazole kills the organisms Trichophyton rubrum and Epidermophyton floccosum,"
DB00338,**Effects on gastric acid secretion**This drug decreases gastric acid secretion .
DB09238,Manidipine produces vasodilation resulting in lower blood pressure 
DB00745,Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy
DB00783,Estradiol acts on the on the estrogen receptors to relieve vasomotor systems (such as hot flashes) and urogenital symptoms (such as vaginal dryness and dyspareunia)
DB01196,Estramustine is an antineoplastic agent indicated in the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate.
DB01022,"Phylloquinone is a vitamin K indicated in the treatment of coagulation disorders due to faulty formation of coagulation factors II, VII,"
DB01127,"Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex)."
DB00313,Valproate has been shown to reduce the incidence of complex partial seizures and migraine headaches.
DB00440,Trimethoprim exerts its antimicrobial effects by inhibiting an essential step in the synthesis of bacterial nucleic acids and proteins.
DB00678,"Losartan is an angiotensin II receptor blocker used to treat hypertension, diabetic nephropathy,"
DB00544,Fluorouracil is an antineoplastic anti-metabolite.
DB00322,"Floxuridine is an anti-metabolite or a pyrimidine analog that works by disrupting the process S-phase of cell division, selectively targeting rapidly dividing cells."
DB00379,"Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active."
DB05219,Crisaborole has broad-spectrum anti-inflammatory activity by mainly targeting phosphodiesterase 4 (PDE4) enzyme that is a key regulator of inflammatory cytokine production
DB00300,"This drug prevents viral DNA chain elongation through inhibition of enzymes necessary for host cell infection viral replication in HIV-1 and Hepatitis B infections ,"
DB06268,Sitaxentan belongs to a class of drugs known as endothelin receptor antagonists (ERAs).
DB11619,"Gestrinone is a synthetic steroidal hormone which has androgenic,"
DB00530,Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer
DB13167,Alclofenac is a non-steroidal anti-inflammatory drug.
DB00751,Epinastine is an antihistamine and an inhibitor of histamine release from the mast cell for topical administration to the eyes
DB00208,Ticlopidine is a prodrug that is metabolised to an as yet undetermined metabolite that acts as a platelet aggregation inhibitor.
DB04575,Quinestrol is the 3-cyclopentyl ether of ethinyl estradiol (the active metabolite).
DB01431,"Allylestrenol is a progestogen structurally related to progesterone that has been given in threatened and recurrent miscarriage, and to prevent premature labour."
DB01601,Lopinavir inhibits the activity of an enzyme critical for the HIV viral lifecycle.
DB01583,Thyroid hormone drugs are natural or synthetic preparations containing T<sub>4</sub> or T<sub>3</sub> or both
DB00924,"Cyclobenzaprine is a skeletal muscle relaxant that works on areas of the brainstem to reduce skeletal muscle spasm, though its exact pharmacodynamic behaviour is currently unclear."
DB00948,"Mezlocillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
DB01251,Gliquidone is an anti-diabetic drug in the sulfonylurea class.
DB00974,Edetate calcium is a heavy metal chelating agent
DB09167,Dosulepin is a tricyclic antidepressant that interacts with various receptors and transporters
DB00689,Cephaloglycin is an antibiotic related to cephalosporin but no longer in common use.
DB00567,Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic.
DB01289,Glisoxepide is a sulfonylurea agent.
DB08860,Pitavastatin is an oral antilipemic agent which inhibits HMG-CoA reductase.
DB01014,Balsalazide is a prodrug that has little or no pharmacologic activity until it is enzymatically cleaved in the colon to produce mesalamine (5-aminosalicylic acid)
DB00274,Cefmetazole is a second-generation cephalosporin.
DB00235,Milrinone is a bipyridine derivative with positive inotropic and lusitropic effects that also results in peripheral vasodilation with minimal chronotropic effects over a therapeutic range of 100 to 300 ng/mL
DB06441,"Cangrelor is an intravenous, direct-acting,"
DB01139,Cephapirin is a first-generation cephalosporin that has a wide spectrum of activity against gram-positive and gram-negative organisms
DB00343,Diltiazem is an antihypertensive and vasodilating agent that works by relaxing the vascular muscle and reducing blood pressure.
DB11079,Trolamine salicylate is a salicylate that inhibits cyclo-oxygenase (COX) enzymes responsible for generating pro-inflammatory factors such as to induce pain and inflammation
DB01015,Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that inhibits a critical step in bacterial folate synthesis.
DB01606,"Tazobactam inhibits the action of bacterial beta-lactamase producing organisms,"
DB13873,"Various clinical studies have shown that elevated levels of total cholesterol, low-desnsity-lipoprotein (LDL-C),"
DB00438,"Ceftazidime is a semisynthetic, broad-spectrum, third-generation cephalosporin antibiotic that is bactericidal through inhibition of enzymes responsible for cell-wall synthesis, primarily penicillin-binding protein 3 (PBP3)."
DB00267,Cefmenoxime is a semisynthetic beta-lactam cephalosporin antibiotic with activity similar to that of cefotaxime.
DB00621,"Oxandrolone is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections,"
DB00641,Simvastatin is an oral antilipemic agent which inhibits HMG-CoA reductase.
DB01330,Cefotetan is a semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly
DB01602,Bacampicillin is a prodrug of ampicillin and is microbiologically inactive
DB01053,"Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
DB01241,Gemfibrozil alters lipid metabolism to treat patients with hyperlipidemia.
DB00834,Mifepristone is a synthetic steroid with antiprogestational effects indicated for the medical termination of intrauterine pregnancy through 49 days' pregnancy
DB00213,"This drug acts to decrease gastric acid secretion, which reduces stomach acidity."
DB04855,Dronedarone is an antiarrhythmic agent that restores normal sinus rhythm and reduces heart rate in atrial fibrillation.
DB00224,Indinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
DB00976,Telithromycin is a ketolide antibiotic which has an antimicrobial spectrum similar or slightly broader than that of penicillin
DB06636,"Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA for the treatment of invasive aspergillosis and invasive mucormycosis,"
DB00091,"Cyclosporine exerts potent immunosuppressive actions on T cells, thereby prolonging survival following organ and bone marrow transplants."
DB00763,Methimazole inhibits the synthesis of thyroid hormones resulting in an alleviation of hyperthyroidism.
DB00273,Topiramate prevents the occurrence of seizures and prevents migraine symptoms by reducing neural pathway excitability.
DB01395,"Drospirenone inhibits the maturation of follicles and inhibits ovulation, preventing pregnancy."
DB00389,Carbimazole is a carbethoxy derivative of methimazole.
DB00281,"Excessive blood levels of lidocaine can cause changes in cardiac output, total peripheral resistance,"
DB01321,Josamycin is a macrolide antibiotic from <i>Streptomyces narbonensis</i>.
DB00252,Phenytoin is an anticonvulsant with a narrow therapeutic index.
DB00686,Pentosan polysulfate sodium is a low molecular weight heparin-like compound.
DB06736,"Aceclofenac is a NSAID that inhibits both isoforms of COX enzyme,"
DB06206,Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery
DB06196,"Icatibant is a potent, specific, competitive, and selective peptidomimetic bradykinin beta2-receptor antagonist."
DB08816,Ticagrelor is a P2Y<sub>12</sub> receptor antagonist that inhibits the formation of thromboses to reduce the risk of myocardial infarction and ischemic stroke
DB00682,"Warfarin is an anticoagulant,"
DB00006,Bivalirudin mediates an inhibitory action on thrombin by directly and specifically binding to both the catalytic site and anion-binding exosite of circulating and clot-bound thrombin
DB00196,"Fluconazole has been demonstrated to show fungistatic activity against the majority of strains of the following microorganisms, curing fungal infections:_Candida albicans, Candida glabrata (Many strains are intermediately susceptible),"
DB01026,"Ketoconazole, similarly to other azole antifungals,"
DB00625,"Efavirenz (dideoxyinosine, ddI) is an oral non-nucleoside reverse transcriptase inhibitor (NNRTI)."
DB09198,Lobeglitazone is an antidiabetic medication from the thiazolidinedione class of drugs.
DB01101,Capecitabine is a fluoropyrimidine carbamate with antineoplastic activity indicated for the treatment of metastatic breast cancer and colon cancer
DB01685,Topiroxostat reduces the synthesis of uric acid by competitively inhibiting xanthine oxidase in a selective and time-dependent manner 
DB09283,Trapidil exerts vasodilatory and antiplatelet effects .
DB00788,"Naproxen is an established non-selective NSAID and is useful as an analgesic, anti-inflammatory and antipyretic."
DB00412,"When rosiglitazone is used as monotherapy, it is associated with increases in total cholesterol, LDL, and HDL."
DB03585,Oxyphenbutazone was withdrawn from the Canadian market in March 1985 due to concerns regarding bone marrow suppression
DB00312,"Pentobarbital, a barbiturate,"
DB01118,"After intravenous administration, amiodarone acts to relax smooth muscles that line vascular walls, decreases peripheral vascular resistance (afterload),"
DB01024,Mycophenolic acid is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH) that blocks _de novo_ biosynthesis of purine nucleotides
DB06209,Prasugrel is a thienopyridine ADP receptor inhibitors which inhibits platelet aggregation by irreversibly binding to P2Y12 receptors
DB00661,"Verapamil is an L-type calcium channel blocker with antiarrhythmic, antianginal, and antihypertensive activity."
DB00468,Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria.
DB00398,No large changes in QTc interval were observed.
DB01124,"Tolbutamide, a first-generation sulfonylurea antidiabetic agent,"
DB05812,"Abiraterone is associated with decreases in PSA levels, tumor shrinkage (as evaluated by RECIST criteria),"
DB09120,Zucapsaicin mediates an antinociceptive action via acting as an agonist at TRPV1.
DB09063,Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy
DB09073,"Due to its mechanism of action, palbociclib inhibits cell growth and suppresses DNA replication in retinoblastoma tumor suppressor gene (RB) proficient cancer cells."
DB00277,"Theophylline, an xanthine derivative chemically similar to caffeine and theobromine,"
DB06210,"Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines,"
DB00599,"Thiopental, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical,"
DB01437,"Glutethimide, like the barbiturates,"
DB01112,Cefuroxime is a &beta;-lactam type antibiotic.
DB00578,Carbenicillin is a semisynthetic penicillin.
DB01060,"Amoxicillin competitively inhibit penicillin binding proteins,"
DB01628,Etoricoxib is a COX-2 selective inhibitor (approximately 106 times more selective for COX-2 inhibition over COX-1)
DB01393,Bezafibrate is an antilipemic agent that lowers cholesterol and triglycerides.
DB00175,The action of pravastatin on the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase produces an increase in the expression of hepatic LDL receptors which in order decreases the plasma levels of LDL cholesterol
DB00833,Cefaclor is a second generation cephalosporin antibiotic with a spectrum resembling first-generation cephalosporins.
DB01017,Minocycline is a tetracycline antibiotic that binds to the bacterial 30S ribosomal subunit and interferes with protein synthesis.
DB00316,Animal and clinical studies have determined that acetaminophen has both antipyretic and analgesic effects.
DB01328,Cefonicid is a second-generation cephalosporin administered intravenously or intramuscularly.
DB00636,Clofibrate is an antilipidemic agent similar to gemfibrozil.
DB04574,Estropipate is an estrogenic substance.
DB00779,Nalidixic acid is a quinolone antibacterial agent for oral administration.
DB00493,Cefotaxime is a third generation intravenous cephalosporin antibiotic.
DB01067,Glipizide is a blood glucose-lowering agent.
DB01095,"Fluvastatin, the first synthetically-derived HMG-CoA reductase inhibitor, is a hydrophilic,"
DB08918,"Levomilnacipran binds with high affinity to human serotonin (5-HT) and norepinephrine (NE) transporters ,"
DB04896,When utilized to treat fibromyalgia
DB01110,Miconazole is an azole antifungal that functions primarily through inhibition of a specific demethylase within the CYP450 complex
DB00169,The in vivo synthesis of the predominant two biologically active metabolites of vitamin D occurs in two steps
DB00207,"Macrolides stop bacterial growth by inhibiting protein synthesis and translation,"
DB00993,"Azathioprine is an immunosuppressive agent which functions through modulation of rac1 to induce T cell apoptosis,"
DB00364,This drug aids in the healing of duodenal ulcers
DB00915,"Amantadine is an antiviral drug which also acts as an antiparkinson agent,"
DB01435,Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops
DB00335,Atenolol is a cardio-selective beta-blocker and as such exerts most of its effects on the heart.
DB13179,"Troleandomycin, like other macrolide antibiotics,"
DB00863,Ranitidine decreases the secretion of gastric acid stimulated by food and drugs.
DB00320,DHE is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes
DB00381,"**General pharmacodynamic effects**Amlodipine has a strong affinity for cell membranes,"
DB00831,Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders
DB01100,Pimozide is an orally active antipsychotic drug product which shares with other antipsychotics the ability to blockade dopaminergic receptors on neurons in the central nervous system.
DB01221,"Ketamine is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone,"
DB00813,Fentanyl produces strong analgesia through its activation of opioid receptors.
DB00950,"Fexofenadine relieves allergy symptoms by antagonizing the actions of histamine,"
DB00537,Ciprofloxacin is a second generation fluoroquinolone that is active against many Gram negative and Gram positive bacteria.
DB01054,"Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris,"
DB00390,"Digoxin is a positive inotropic and negative chronotropic drug,"
DB00966,Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT<sub>1</sub> receptor subtype
DB01340,Cilazapril inhibits the production angiotensin II.
DB00790,"Perindopril is a nonsulfhydryl prodrug that is metabolized via first pass effect (62%) and systemic hydrolysis (38%) to perindoprilat, its active metabolite,"
DB01103,Quinacrine has been used as an antimalarial drug and as an antibiotic.
DB00276,Amsacrine is an aminoacridine derivative that is a potent intercalating antineoplastic agent.
DB00570,Vinblastine is a vinca alkaloid antineoplastic agent.
DB00669,Sumatriptan constricts cranial blood vessels and prevents the release of vasoactive peptides.
DB13874,"In a study involving adult patients with relapsed or refractory AML, overall response rate of 40."
DB09102,Daclatasvir is a direct-acting antiviral agent that targets the NS5A and causes a decrease in serum HCV RNA levels
DB00936,"Salicylic acid treats acne by causing skin cells to slough off more readily,"
DB01088,Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds.
DB00770,Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation.
DB00608,"Chloroquine inhibits the action of heme polymerase,"
DB00655,"Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine,"
DB00203,In vitro studies have shown that sildenafil is selective for phosphodiesterase-5 (PDE5) .
DB00810,Biperiden is a weak peripheral anticholinergic agent.
DB01037,Dopamine is an essential chemical that occurs in many parts of the body.
DB01370,"A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26."
DB01162,Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocker
DB06154,"Organic nitrate which causes systemic vasodilation, decreasing cardiovascular preload ."
DB00624,Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual characteristics
DB01234,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
DB00694,Daunorubicin is an anthracycline antibiotic and antineoplastic agent
DB00264,Administration of metoprolol in normal subjects is widely reported to produce a dose-dependent reduction on heart rate and cardiac output.
DB00367,"Levonorgestrel prevents pregnancy by interfering with ovulation, fertilization,"
DB06414,Clinical trials have shown no prolongation of QT intervals on electrocardiograms after 8 days of dosing
DB05351,Dexlansoprazole is a proton pump inhibitor (PPI) and is included in the drug class of antisecretory compounds
DB04868,"Nilotinib is a transduction inhibitor that targets BCR-ABL, c-kit and PDGF, for the potential treatment of various leukemias,"
DB00477,Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia.
DB00503,Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
DB00520,"Caspofungin is an antifungal drug, and belongs to a new class termed the echinocandins."
DB00690,"Flurazepam, a benzodiazepine derivative, is a hypnotic agent which does not appear to decrease dream time as measured by rapid eye movements (REM)."
DB00358,Sporozoites located in the salivary glands of mosquitoes infected with malaria parasites are introduced into the bloodstream of a human host during mosquito feeding.
DB01032,"Probenecid is a uricosuric and renal tubular blocking agent and is used in combination with colchicine to treat chronic gouty arthritis when complicated by frequent,"
DB00201,"Caffeine stimulates the central nervous system (CNS), heightening alertness, and sometimes causing restlessness and agitation."
DB00701,Amprenavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
DB08827,Lomitapide directly inhibits microsomal triglyceride transfer protein (MTP)
DB00345,"Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid."
DB00637,Astemizole is a second generation H<sub>1</sub>-receptor antagonist.
DB00351,Megestrol is a synthetic progestin and has the same physiologic effects as natural progesterone.
DB11363,Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase
DB13879,"In a biochemical assay studying clinical isolates of HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a, glecaprevir displayed IC50 values ranging from 3."
DB12026,Voxilaprevir is a direct-acting antiviral agent that targets viral NS3/4A protein and causes a decrease in serum HCV RNA levels
DB00418,"Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical,"
DB00474,"Methohexital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical,"
DB00671,"Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime."
DB01207,"Ridogrel, a combined thromboxane synthase inhibitor and receptor antagonist,"
DB01175,Escitalopram belongs to a class of medications called selective serotonin re-uptake inhibitors (SSRIs)
DB00726,Trimipramine is a tricyclic antidepressant.
DB00437,Allopurinol decreases the production of uric acid by stopping the biochemical reactions that precede its formation .
DB00487,Pefloxacin is a fluoroquinolone antibiotic.
DB00176,"Fluvoxamine, an aralkylketone-derivative agent ,"
DB00193,Tramadol modulates the descending pain p
DB00957,Norgestimate is a progestin that suppresses ovulation for contraception and reduces free testosterone to treat moderate acne vulgaris.
DB09265,Lixisenatide acts as an agonist at the GLP-1 receptor.
DB09256,Tegafur is an antineoplastic agent that belongs in the class of pyrimidine analogues.
DB06724,"Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid,"
DB08938,"Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux."
DB00500,Tolmetin is a nonsteroidal anti-inflammatory agent.
DB01384,Paramethasone is a glucocorticoid with the general properties of corticosteroids
DB01047,Fluocinonide is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
DB00687,Fludrocortisone is a synthetic mineralocorticoid used to replace endogenous in conditions resulting in missing or inadequate endogenous synthesis
DB01708,DHEA is naturally produced from cholesterol through two cytochrome P450 enzymes.
DB00741,"Hydrocortisone binds to the glucocorticoid receptor leading to downstream effects such as inhibition of phospholipase A2, NF-kappa B, other inflammatory transcription factors,"
DB00180,Flunisolide is a synthetic corticosteroid.
DB08881,"BRAF activation results in cell growth, proliferation, and metastasis."
DB00658,Patients with end-stage renal disease (ESRD) retain phosphorus and can develop hyperphosphatemia.
DB09147,"Iron supplementation typically results in increases in serum iron, transferrin-bound iron,"
DB09275,Bismuth subcitrate is very effective in the treatment of gastroduodenal disorders and appears to act via several mechanisms.
DB03754,An organic amine proton acceptor.
DB09281,Magnesium trisilicate works by increasing the pH of gastric juice via a neutralisation reaction.
DB00896,Rimexolone is a glucocorticoid corticosteroid for systemic use.
DB00443,"Corticosteroids bind to the glucocorticoid receptor inhibiting pro-inflammatory signals,"
DB00860,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
DB00394,"Inflammatory conditions, including asthma, dermatoses, and allergic rhinitis,"
DB00764,"Mometasone is a medium-potency synthetic corticosteroid with antiinflammatory, antipruritic,"
DB02187,"Equilin is a component of Premarin (conjugated estrogens), a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 alpha-dihydroequilin,"
DB06792,In vitro studies have shown that lanthanum binds phosphate in the physiologically relevant pH range of 3 to 7.
DB09267,"In general,"
DB01591,Solifenacin antagonizes the M2 and M3 muscarinic receptors in the bladder to treat an overactive bladder.
DB13595,"Various non-prescription antacid products are available to the general public to purchase and use as a treatment for relieving the occasional,"
DB00346,"By selectively inhibiting alpha adrenergic receptors in the lower urinary tract, alfuzosin causes smooth muscle relaxation in the bladder neck and prostate, improving urine flow, thereby reducing BPH symptoms."
DB02546,"Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL),"
DB00223,"Like other topical corticosteroids, diflorasone has anti-inflammatory, antipruritic, and vasoconstrictive properties."
DB09091,Tixocortol presents the characteristic of local action which reduces significantly the side effects of systemic glucocorticoids.
DB01151,"Desipramine, a secondary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene."
DB00324,Corticosteroids such as fluorometholone inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing.
DB00663,"Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties."
DB01410,"Ciclesonide is a pro-drug that is enzymatically hydrolyzed to a pharmacologically active metabolite,"
DB00620,Triamcinolone is a corticosteroid with anti-inflammatory properties.
DB00288,Amcinonide is a topical corticosteroid.
DB08971,Fluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders
DB08970,Fluprednidene is a corticosteroid.
DB00104,Octreotide mimics the naturally occurring hormone known as somatostatin.
DB00333,"Overall, methadone's pharmacological actions result in analgesia, suppression of opioid withdrawal symptoms, sedation, miosis (through binding to receptors in the pupillary muscles), sweating, hypotension,"
DB08893,"Mirabegron exerts its pharmacologic effects by forcing bladder smooth muscle to relax,"
DB00734,"The primary action of risperidone is to decrease dopaminergic and serotonergic pathway activity in the brain,"
DB01189,Desflurane is a general inhalation anesthetic.
DB01238,"Aripiprazole has high affinity for serotonin type 2 (5HT2), dopamine type 2 (D2), alpha1 and 2 adrenergic,"
DB00674,Galantamine is a competitive and reversible inhibitor of acetylcholinesterase that works to increase acetylcholine levels.
DB09080,"Olodaterol is a potent agonist of the human beta2-adrenergic receptor in vitro,"
DB00710,Ibandronate is a nitrogen containing bisphosphonate used to treat and prevent osteoporosis in postmenopausal women.
DB13783,The effect of acemetacin causes a weak reduction of prostaglandin synthesis which generates an anti-inflammatory and analgesic effect
DB01248,Docetaxel is a taxoid antineoplastic agent.
DB06772,Cabaitaxel has anti-tumour properties and is effective against docetaxel-sensitive and -insensitive tumours
DB11093,Increases plasma calcium levels leading 
DB00258,Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia
DB09146,Significant increases in serum iron and serum ferritin and significant decreases in total iron binding capacity occurred four weeks from the initiation of iron sucrose treatment
DB00588,"Systemically, fluticasone propionate activates glucocorticoid receptors, and inhibits lung eosinophilia in rats."
DB13158,"Topical corticosteroid like clobetasone are synthetic derivatives of cortisone which produce anti-inflammatory, antiproliferative,"
DB01260,Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use.
DB00838,"Like other topical corticosteroids, clocortolone has anti-inflammatory, antipruritic, and vasoconstrictive properties."
DB00531,Cyclophosphamide is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer
DB11126,Calcium Gluconate is the gluconate salt of calcium.
DB11348,Calcium phosphate reacts with acid in the stomach to raise the pH 
DB01396,Digitoxin is a cardiac glycoside sometimes used in place of DIGOXIN.
DB01592,The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia.
DB06723,"Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid,"
DB01390,"Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration,"
DB01164,Calcium is the fifth most abundant element in the body and the major fraction is in the bony structure.
DB09104,"As an antacid,"
DB01377,Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase.
DB00846,"Flurandrenolide is primarily effective because of its anti-inflammatory, antipruritic,"
DB11921,"Deflazacort exerts anti-inflammatory activity in DMD, likely improving various symptoms,"
DB13231,"Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source,"
DB06781,Difluprednate is a corticosteroid used as an anti-inflammatory steroidal drug used primarily in ocular surgery
DB08905,"By significantly reducing estrogen levels in the bloodstream, formestane may exhibit antitumor activity."
DB01130,Corticosteroids diffuse across cell membranes and complex with specific cytoplasmic receptors.
DB01229,"Paclitaxel is a taxoid antineoplastic agent indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary,"
DB13142,Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets
DB00547,"Like other topical corticosteroids, desoximetasone has anti-inflammatory, antipruritic, and vasoconstrictive properties."
DB09095,"Diflucortolone is a steroid with the properties of being an anti-inflammatory,"
DB01078,"Deslanoside is a cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms,"
DB01069,"Promethazine is is a histamine H1 antagonist that can be used for it's ability to induce sedation, reduce pain,"
DB06663,Signifor® is an analogue of somatostatin that promotes reduced levels of cortisol secretion in Cushing's disease patients
DB01268,"Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA on January 26,"
DB00862,Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH)
DB00199,"Macrolides, such as erythromycin, stop bacterial growth by inhibiting protein synthesis and translation, treating bacterial infections."
DB00363,Clozapine is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia
DB01075,"Diphenhydramine has anti-histaminic (H1-receptor), anti-emetic,"
DB00450,Droperidol produces marked tranquilization and sedation.
DB00653,"Magnesium sulfate is a small colorless crystal used as an anticonvulsant, a cathartic,"
DB00934,Maprotiline is a tetracyclic antidepressant.
DB00753,Isoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia.
DB06825,"The first administration of triptorelin is followed by a transient surge of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol,and testosterone."
DB08871,Linear
DB00808,"Classified as a sulfonamide diuretic, indapamide is an effective antihypertensive agent and by extension,"
DB00014,The pharmacokinetics of goserelin have been determined in both male and female healthy volunteers and patients.
DB08868,"In multiple sclerosis, fingolimod binds to sphingosine receptors, reducing its associated neuroinflammation."
DB00596,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
DB01380,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
DB00959,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals,"
DB09241,Methylene blue is an oxidation-reduction agent.
DB01045,Rifampin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells.
DB06786,"Halcinonide is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses,"
DB06237,Avanafil is a strong competitive inhibitor of phosphodiesterase 5 (PDE5) with a demonstrated _in vitro_ IC<sub>50</sub> of 5.
DB00611,Butorphanol is a synthetic opioid agonist-antagonist analgesic with a pharmacological and therapeutic profile that has been well established since its launch as a parenteral formulation in 1978
DB01209,Dezocine is a parenteral narcotic analgesic possessing both agonist and antagonist activity.
DB01452,The onset of heroin's effects is dependent on the method of administration.
DB00295,"Morphine binding to opioid receptors blocks transmission of nociceptive signals, signals pain-modulating neurons in the spinal cord,"
DB00802,Alfentanil is a synthetic opioid analgesic.
DB01551,"Possible opioid related side effects include, but are not limited to, drowsiness, nausea, headache, dry mouth, constipation, difficulty passing urine,"
DB00318,**General effects**Codeine is a weak narcotic pain reliever and cough suppressant that is similar to morphine and hydrocodone
DB01002,"Levobupivacaine, a local anesthetic agent, is indicated for the production of local or regional anesthesia or analgesia for surgery, for oral surgery procedures,"
DB11609,Normethadone is an opioid which suppresses coughing by central and peripheral mechanisms 
DB01200,Bromocriptine stimulates centrally-located dopaminergic receptors resulting in a number of pharmacologic effects.
DB09082,Vilanterol is a selective long-acting beta2-adrenergic agonist (LABA) with inherent 24-hour activity for once daily treatment of COPD and asthma
DB01169,"Arsenic Trioxide is indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from,"
DB01001,"Salbutamol (INN) or albuterol (USAN), a moderately selective beta(2)-receptor agonist similar in structure to terbutaline,"
DB00449,Dipivefrin is a member of a class of drugs known as prodrugs
DB09242,"Antihypertensive agent whose site of action is the Central Nervous System (CNS),"
DB00413,"**Parkinson's Disease**Through the stimulation of dopamine receptors,"
DB00435,"Persistent pulmonary hypertension of the newborn (PPHN) occurs as a primary developmental defect or as a condition secondary to other diseases such as meconium aspiration syndrome (MAS), pneumonia,"
DB00178,"Ramipril is an ACE inhibitor similar to benazepril, fosinopril and quinapril."
DB01392,Yohimbine is an indolalkylamine alkaloid with chemical similarity to reserpine.
DB00212,Remikiren is an orally available renin inhibitor with an established blood pressure-lowering effect in patients with essential hypertension.
DB01407,Clenbuterol is a substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses.
DB04840,Debrisoquin is an adrenergic neuron-blocking drug similar in effects to guanethidine.
DB01291,Pirbuterol is a beta-2 adrenergic bronchodilator.
DB01102,"Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses,"
DB00657,"Mecamylamine is a potent, oral antihypertensive agent and ganglion blocker,"
DB00849,"Methylphenobarbital, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines,"
DB00598,Labetalol antagonizes various adrenergic receptors to decrease blood pressure.
DB00571,Propranolol is a beta-adrenergic receptor antagonist used to treat hypertension.
DB04846,Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris.
DB00612,"Bisoprolol decreases heart rate (chronotropy), decreases contractility (inotropy),"
DB00373,"Timolol, when administered by the ophthalmic route, rapidly reduces intraocular pressure."
DB00681,Amphotericin B shows a high order of <i>in vitro</i> activity against many species of fungi.
DB01041,"Thalidomide, originally developed as a sedative, is an immunomodulatory and anti-inflammatory agent with a spectrum of activity that is not fully characterized."
DB01466,Ethylmorphine is metabolized by the enzyme cytochrome P450 2D6 to morphine
DB09286,"Pipamperone is an antipsychotic medication that has sedative effects, which may be beneficial in the management of agitation and disordered sleep ."
DB00652,Pentazocine is a potent analgesic which when administered orally in a 50 mg dose appears equivalent in analgesic effect to 60 mg (1 grain) of codeine
DB01192,Oxymorphone is a semi-synthetic opioid substitute for morphine.
DB00818,Propofol is a sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation.
DB00633,"Dexmedetomidine activates 2-adrenoceptors,"
DB01274,"Arformoterol, the active (R,R)-enantiomer of formoterol, is a selective long-acting β2-adrenergic receptor agonist (beta2-agonist) that has two-fold greater potency than racemic formoterol (which contains both the (S,S) and (R,"
DB05039,Bronchodilator drugs are the foundation for the treatment of chronic obstructive pulmonary disease.
DB09227,Barnidipine reduces peripheral resistance and lowers blood pressure.
DB01244,Bepridil is a calcium channel blocker that has well characterized anti-anginal properties and known but poorly characterized type 1 anti-arrhythmic and anti-hypertensive properties
DB09232,Administration of cilnidipine has been shown to present an antisympathetic profile in vitro and in vivo.
DB00401,"Nisoldipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris,"
DB00668,Epinephrine is a sympathomimetic drug
DB00727,"Nitroglycerin causes the relaxation of vascular smooth muscles, causing arteriolar and venous dilatation."
DB00594,"Amiloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents."
DB00177,Valsartan inhibits the pressor effects o
DB00519,"Trandolapril is the ethyl ester prodrug of a nonsulfhydryl ACE inhibitor, trandolaprilat."
DB00692,Phentolamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma.
DB00703,Methazolamide is topical carbonic anhydrase inhibitor.
DB00542,"Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by esterases to its active Benazeprilat,"
DB00816,"Orciprenaline (also known as metaproterenol), a synthetic amine, is structurally and pharmacologically similar to isoproterenol."
DB00752,Tranylcypromine belongs to a class of antidepressants called monoamine oxidase inhibitors (MAOIs).
DB01355,Hexobarbital is a barbiturate derivative having hypnotic and sedative effects.
DB00421,Originally spironolactone was only studied for its potassium sparing diuretic effect.
DB00708,"**Effect on the Central Nervous System (CNS)** In clinical settings, sufentanil exerts its principal pharmacologic effects on the central nervous system."
DB06738,Ketobemidone is a powerful opioid analgesic.
DB00899,Remifentanil is an opioid agonist with rapid onset and peak effect and ultra-short duration of action.
DB00575,"Clonidine functions through agonism of alpha-2 adrenoceptors which have effects such as lowering blood pressure, sedation,"
DB01433,Methadyl Acetate is a narcotic analgesic with a long onset and duration of action
DB00844,Nalbuphine is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series.
DB00454,Meperidine is a synthetic opiate agonist belonging to the phenylpiperidine class.
DB00647,"Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone."
DB00714,Apomorphine is a dopaminergic agonist that may stimulate regions of the brain involved in motor control
DB00310,Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment
DB09292,"n a 7-day valsartan-controlled study in patients with reduced ejection fraction (HFrEF), administration of sacubitril + valsartan (Entresto) resulted in a significant non-sustained increase in natriuresis,"
DB01282,"Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth."
DB00325,Nitroprusside a powerful vasodilator relaxes the vascular smooth muscle and produce consequent dilatation of peripheral arteries and veins.
DB00631,Clofarabine is a purine nucleoside antimetabolite that differs from other puring nucleoside analogs by the presence of a chlorine in the purine ring and a flourine in the ribose moiety
DB00922,Levosimendan is a new Ca-sensitizing inotropic agent.
DB09279,Fimasartan is a selective angiotensin receptor 1 (AR1) inhibitor 
DB00800,"Fenoldopam is an agonist at D<sub>1</sub>-like dopamine receptors, binds to &alpha;<sub>2</sub>-adrenoceptors,"
DB00956,Hydrocodone inhibits pain signaling in both the spinal cord and brain .
DB09214,This drug is an isomer of ketoprofen.
DB00397,"Phenylpropanolamine (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion."
DB00841,"Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic,"
DB01247,"In vivo and in vitro studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver."
DB00695,"Furosemide manages hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease,"
DB01408,Bambuterol is a long acting beta2-adrenoceptor agonist used in the treatment of asthma.
DB08907,This drug increases urinary glucose excretion and decreases the renal threshold for glucose (RTG) in a dose-dependent manner 
DB00187,"Esmolol, commonly marketed under the trade name Brevibloc,"
DB00521,"Carteolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity."
DB00497,Oxycodone acts directly on a number of tissues not related to its analgesic effect.
DB00232,"Methyclothiazide, a diuretic-antihypertensive agent, is a member of the benzothiadiazine (thiazide) class of drugs."
DB09236,acidipine is a specific and potent calcium antagonist with a predominant selectivity for calcium channels in the vascular smooth muscle
DB00755,"Tretinoin, also known as all-<i>trans</i>-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol)."
DB00883,Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris
DB13139,It acts by relaxing smooth muscle in the bronchial tubes to increase air flow and relieve acute shortness of breath
DB09220,"Nicorandil is a potassium channel opener with nitrovasodilator (NO donor) actions,"
DB00780,The elimination of monoamine oxidase by phenelzine results in the elevation of brain amines such as 2-phenylethylamine which is a metabolite of phenelzine
DB00921,Buprenorphine interacts predominately with the opioid mu-receptor.
DB06712,"Nilvadipine is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine."
DB06204,Tapentadol is a centrally-acting synthetic analgesic that is 18 times less potent than morphine in binding mu-opioid receptors
DB00486,Nabilone is a cannabinoid with therapeutic uses.
DB01227,Levomethadyl acetate (also known as LAAM) is a synthetic synthetic opioid analgesic with multiple actions quantitatively similar to those as morphine
DB00679,Thioridazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders
DB00323,"Tolcapone is a potent, selective, and reversible inhibitor of catechol-O-methyltransferase (COMT)."
DB00774,Hydroflumethiazide is an oral thiazide used to treat hypertension and edema.
DB01143,Amifostine is an organic thiophosphate c
DB06212,Urine volume and fluid intake increase in a dose dependent manner which results in overall negative fluid balance in patients taking tolvaptan
DB01199,Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid
DB00483,Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation
DB00476,"Duloxetine, through increasing serotonin and norepinephrine concentrations in Onuf's nucleus,"
DB00933,"Mesoridazine, the besylate salt of a metabolite of thioridazine,"
DB00292,Etomidate is a non-barbiturate hypnotic that acts at the level of the reticular-activating system to produce anesthesia.
DB01122,"Ambenonium, similar to pyridostigmine and neostigmine,"
DB00981,"Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission."
DB01233,Metoclopramide increases gastric emptying by decreasing lower esophageal sphincter (LES) pressure.
DB01115,Nifedipine is an inhibitor of L-type voltage gated calcium channels that reduces blood pressure and increases oxygen supply to the heart
DB06711,"Naphazoline is a sympathomimetic alpha adrenergic agonist that acts to vasoconstrict nasal or ocular arterioles,"
DB01611,Hydroxychloroquine affects the function of lysozomes in humans as well as plasmodia
DB00680,Moricizine is used to treat irregular heartbeats (arrhythmias) and to maintain a normal heart rate.
DB01116,Trimethaphan is indicated for production
DB01154,"Thiamylal, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines,"
DB00820,"Tadalafil exerts a therapeutic effect in ED by increasing sexual stimulation-dependant smooth muscle relaxation in the penis,"
DB00484,Brimonidine is a highly selective alpha-2 adrenergic receptor agonist that is 1000-fold more selective for the alpha2-adrenergic receptor than the alpha1-adrenergic receptor.
DB09291,"Rolapitant is a potent, highly selective,"
DB06697,"In the body, artemether is metabolized into the active metabolite metabolite dihydroartemisinin."
DB00349,"Similar to other benzodiazepines, clobazam binds to the interface of the α and γ2-subunit of the GABA-A receptor."
DB00508,"Triflupromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists."
DB00206,Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage
DB01615,Aceprometazine is a drug with neuroleptic and anti-histamine properties.
DB01614,Acepromazine is one of the phenothiazine derivative psychotropic drugs.
DB01245,Decamethonium acts as a depolarizing muscle relaxant or neuromuscular blocking agent.
DB00772,Malathion is an organophosphate insecticide commonly used to control mosquitos and other flying insects.
DB00545,"Pyridostigmine bromide, designated as 3-hydroxy-1-methyl-pyridinium bromide dimethyl-carbamate,"
DB00677,Isoflurophate is used as ocular drops in the treatment of chronic glaucoma.
DB00696,Ergotamine is a vasoconstrictor and alpha adrenoreceptor antagonist.
DB00524,"Metolazone is a quinazoline diuretic,"
DB06694,Xylometazoline is a sympathomimetic agent that causes vasoconstriction of the nasal mucosa.
DB00217,Bethanidine is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission.
DB01577,"Methamphetamine is a potent central nervous system stimulant which affects neurochemical mechanisms responsible for regulating heart rate, body temperature, blood pressure, appetite,"
DB00796,"Candesartan cilexetil is an ARB prodrug that is rapidly converted to candesartan, its active metabolite,"
DB00275,"Overall, olmesartan's physiologic effects lead to reduced blood pressure, lower aldosterone levels, reduced cardiac activity,"
DB00613,"Amodiaquine, a 4-aminoquinoline similar to chloroquine in structure and activity,"
DB01119,Diazoxide is a potassium channel activator.
DB01168,Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer
DB00805,"Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain."
DB00182,From its mechanism of action
DB09244,"Pirlindole regulates that metabolism of norepinephrine and catecholamines, leading to relief of depressive symptoms."
DB00614,Furoxone has a broad antibacterial spectrum covering the majority of gastrointestinal tract pathogens including E.
DB09280,"Results from clinical trials indicated that treatment with Orkambi (lumacaftor/ ) results in improved lung function, reduced chance of experiencing a pulmonary exacerbation, reduced sweat chloride,"
DB00705,Delavirdine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1)
DB00227,Lovastatin is an oral antilipemic agent which reversibly inhibits HMG-CoA reductase.
DB00501,Cimetidine is a histamine H<sub>2</sub>-receptor antagonist.
DB00280,"Disopyramide is an anti-arrhythmic drug indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia that are life-threatening."
DB09204,Preclinical studies showed a lack of intrinsic sympathomimetic activities or membrane-establishing properties.
DB01319,Fosamprenavir is hydrolyzed by cellular phosphatases to the antiretroviral protease inhibitor amprenavir.
DB00951,"Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically <i>M."
DB09039,Eliglustat is a specific inhibitor of glucosylceramide synthase (IC<sub>50</sub> =10 ng/mL).
DB00420,Promazine belongs to a group of medications known as the phenothiazine antipsychotics.
DB00850,"Perphenazine is a piperazinyl phenothiazine, acts on the central nervous system,"
DB01018,Guanfacine is a selective alpha-2A adrenergic receptor agonist but it is unclear how this translates to the treatment of ADHD
DB00944,Demecarium is a long-acting cholinesterase inhibitor and potent miotic.
DB00436,"Bendroflumethiazide, a thiazide diuretic,"
DB00393,Nimodipine belongs to the class of pharmacological agents known as calcium channel blockers
DB00528,"Lercanidipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris,"
DB06707,Levonordefrin is a sympathomimetic amine used as a vasoconstrictor in local anesthetic solutions.
DB00629,"Guanabenz, a centrally acting &alpha;-2 adrenergic agonist,"
DB09112,Sodium nitrite reverses cyanide toxicity and produces blood vessel dilation 
DB08896,Regorafenib is an orally-administered inhibitor of multiple kinases.
DB00226,High blood pressure adds to the work load of the heart and arteries.
DB01580,Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity.
DB00433,Prochlorperazine is an antipsychotic agent that works to promote postsynaptic inhibition of dopaminergic neurons.
DB01267,Paliperidone is an atypical antipsychotic developed by Janssen Pharmaceutica.
DB09235,"Dihydropyridines (DHPs), act mainly on L-type calcium channels, essentially causing reflex tachycardia,"
DB01158,Bretylium is a bromobenzyl quaternary ammonium compound which selectively accumulates in sympathetic ganglia and their postganglionic adrenergic neurons where it inhibits norepinephrine release by depressing adrenergic nerve terminal excitability
DB09477,"Enalaprilat injection results in the reduction of both supine and standing systolic and diastolic blood pressure, usually with no orthostatic component."
DB01622,Thioproperazine is a potent neuroleptic with antipsychotic properties.
DB00195,"Betaxolol is a competitive, beta(1)-selective (cardioselective) adrenergic antagonist."
DB00872,"Conivaptan is a nonpeptide,"
DB00214,It is widely known that administration of torasemide can attenuate renal injury and reduce the severity of acute renal failure.
DB01203,Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure
DB01224,"Quetiapine improves the positive and negative symptoms of schizophrenia and major depression by acting on various neurotransmitter receptors, such as the serotonin and dopamine receptors."
DB01010,Edrophonium is a short and rapid-acting anticholinesterase drug.
DB01324,"As a thiazide diuretic, Polythiazide inhibits the sodium-chloride symporter which decreases solute reabsorption leading to a retention of water in the urine,"
DB01186,Pergolide stimulates centrally-located dopaminergic receptors resulting in a number of pharmacologic effects.
DB00852,Pseudoephedrine causes vasoconstriction which leads to a decongestant effect.
DB01246,"Trimeprazine (also known as Alimemazine) is a tricyclic antihistamine, similar in structure to the phenothiazine antipsychotics,"
DB00321,**Effects in pain and depression**Amitriptyline is a tricyclic antidepressant and an analgesic.
DB00446,Chloramphenicol is a broad-spectrum antibiotic that was derived from the bacterium Streptomyces venezuelae and is now produced synthetically.
DB06708,Lumefantrine is a blood schizonticide active against erythrocytic stages of <i>Plasmodium falciparum</i>.
DB06413,"Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA),"
DB01129,Rabeprazole prevents the production of acid in the stomach.
DB06729,Sulfaphenazole is a sulfonamide antibacterial
DB00557,Hydroxyzine blocks the activity of histamine to relieve allergic symptoms such as pruritus
DB01114,In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils.
DB00904,"Ondansetron is a highly specific and selective serotonin 5-HT<sub>3</sub> receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors ,"
DB00748,Carbinoxamine is a first generation antihistamine of the ethanolamine class.
DB01057,"Echothiophate Iodide is a potent,"
DB01087,Primaquine is an antimalarial agent and is the essential co-drug with chloroquine in treating all cases of malaria.
DB06262,Droxidopa is an orally active synthetic precursor of norepinephrine that increases the deficient supply of norepinephrine in patients with NOH
DB05271,Rotigotine is an agonist at all 5 dopamine receptor subtypes (D1-D5) but binds to the D3 receptor with the highest affinity
DB06287,Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC).
DB06684,Vilazodone increases serotonin levels in the brain by inhibiting the reuptake of serotonin while acting as a partial agonist on serotonin-1A receptors
DB00822,Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol
DB00514,Dextromethorphan is an opioid-like molecule indicated in combination with other medication in the treatment of coughs and pseudobulbar affect.
DB00259,Sulfanilamide is a sulfonamide antibiotic.
DB02701,An important compound functioning as a component of the coenzyme NAD.
DB04839,Cyproterone is an antiandrogen.
DB01096,"Oxamniquine is an anthelmintic with schistosomicidal activity against <i>Schistosoma mansoni</i>,"
DB01058,Praziquantel is an anthelmintic used in most schistosome and many cestode infestations.
DB00843,"By inhibiting the acetylcholinesterase enzyme, donepezil improves the cognitive and behavioral signs and symptoms of Alzheimer's Disease, which may include apathy, aggression, confusion,"
DB01400,Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine.
DB00865,"Benzphetamine, a phenylalkylamin,"
DB00496,Darifenacin is a competitive muscarinic receptor antagonist
DB01626,Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties.
DB01156,"Bupropion is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitors, or other known antidepressant agents."
DB01043,**General effects**This drug inhibits calcium influx into cells that is normally caused by chronic NMDA receptor activation by glutamate .
DB00857,Terbinafine is an allylamine antifungal that inhibits squalene epoxidase (also known as squalene monooxygenase) to prevent the formation of ergosterol and cause an accumulation of squalene
DB00907,"Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral,"
DB01182,"Propafenone is a Class 1C antiarrhythmic drug with local anesthetic effects, and a direct stabilizing action on myocardial membranes."
DB01021,"Trichloromethiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis,"
DB00797,Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN)
DB01608,Pericyazine is a phenothiazine of the piperidine group.
DB00606,"Like other thiazides, cyclothiazide promotes water loss from the body (diuretics)."
DB04948,"In clinical trials, lofexidine presented more severe opioid withdrawal effects than observed with methadone."
DB00935,Oxymetazoline is an adrenergic α<sub>1</sub>- and α<sub>2</sub>-agonist and a direct-acting sympathomimetic drug.
DB06267,Udenafil is a potent selective phosphodiesterase type 5 (PDE5) inhibitor
DB00296,"In contrast to most other local anesthetics, the presence of does not affect the time of onset, duration of action,"
DB08877,"Ruxolitinib is an antineoplastic agent that inhibits cell proliferation,"
DB00457,"**Effects on blood pressure**The pharmacodynamic and therapeutic effect of this drug includes is a decrease in blood pressure as well as clinically significant decreases in cardiac output,"
DB00489,Sotalol is a competitive inhibitor of the rapid potassium channel.
DB11730,"Ribociclib is a selective cyclin-dependent kinase inhibitor,"
DB09048,Netupitant is an antiemitic drug approve
DB04871,Lorcaserin produced a dose-dependent weight loss over a 12-week period by promoting satiety and decreasing food consumption
DB00502,"Use of the first-generation antipsychotics (including haloperidol) is considered highly effective for the management of the ""positive"" symptoms of schizophrenia including hallucinations, hearing voices, aggression/hostility, disorganized speech,"
DB06603,"Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma."
DB00623,Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders
DB00880,"Like other thiazides, chlorothiazide promotes water loss from the body (diuretics)."
DB00742,"Chemically, mannitol is an alcohol and a sugar, or a polyol; it is similar to xylitol or sorbitol."
DB08895,Tofacitinib targets inflammation present in rheumatoid arthritis by inhibiting the janus kinases involved in the inflammatory response pathway
DB00869,Dorzolamide is a carbonic anhydrase inhibitor that reduces elevated intraocular pressure in open-angle glaucoma or ocular hypertension.
DB00287,"Travoprost, an isopropyl ester prodrug,"
DB01367,Rasagiline is a propargylamine and an irreversible inhibitor of monoamine oxidase (MAO).
DB00999,"Hydrochlorothiazide prevents the reabsorption of sodium and water from the distal convoluted tubule,"
DB00881,Quinapril is a prodrug of an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension or adjunct in the treatment of heart failure
DB01193,"Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range."
DB09282,"Molsidomine leads to smooth muscle relaxation in the coronary blood vessels,"
DB06589,Pazopanib is a synthetic indazolylpyrimidine and reaches steady state concentrations of >15 μg/ml
DB00556,"Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures,"
DB08864,Rilpivirine is a non-nucleoside reverse transcriptase inhibitor that inhibits the replication of HIV-1
DB00204,Dofetilide is an antiarrhythmic drug with Class III (cardiac action potential duration prolonging) properties and is indicated for the maintenance of normal sinus rhythm
DB01020,Isosorbide mononitrate is an anti-anginal agent and vasodilator that relaxes vascular smooth muscle to prevent and manage angina pectoris.
DB01144,"Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma,"
DB00601,Linezolid is an oxazolidinone antibacterial agent effective against most strains of aerobic Gram-positive bacteria and mycobacteria
DB00610,Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure.
DB00866,"Alprenolol is a non-selective beta-blocker used in the treatment of hypertension, edema, ventricular tachycardias,"
DB00697,"**A note on spasticity**Spasticity is an increase in muscle accompanied by uncontrolled,"
DB00968,"Antihypertensive effects of methyldopa are mostly mediated by its pharmacologically active metabolite, alpha-methylnorepinephrine,"
DB01170,High blood pressure can cause the heart and arteries to not function properly.
DB00654,Latanoprost effectively decreases intraocular pressure by increasing uveoscleral outflow.
DB00905,High intraocular pressure is a major risk factor for glaucoma-related visual field loss.
DB02638,"Terlipressin mimics the biological effects of endogenous vasopressin,"
DB09245,This drug has been shown to help manage the symptoms of depression by maintaining neuro-synaptic levels of serotonin and catecholamines while regulating their metabolism
DB08883,Perampanel is involved in inhibiting neuronal excitation in the central nervous system leading to such effects as decreased pyschomotor performance
DB01440,GHB predominantly works at two distinct binding sites in the central nervous system: it works as an agonist at the newly-characterized excitatory GHB receptor
DB06690,"Nitrous oxide, commonly known as ""laughing gas"", is a chemical compound with the chemical formula N2O."
DB01595,Nitrazepam is a type of benzodiazepine drug.
DB00402,Eszopiclone rapidly induces sleep and decreases sleep latency.
DB00807,Proparacaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.
DB01178,Chlormezanone is a non-benzodiazepine muscle relaxant.
DB01198,Zopiclone is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia
DB01589,Quazepam is a benzodiazepine derivative.
DB00475,"Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions."
DB00829,"Diazepam is a benzodiazepine that exerts anxiolytic, sedative, muscle- relaxant,"
DB00368,Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction
DB06201,At high concentrations will inhibit action of mGluR5 subtype receptors thus preventing the production of glutamate
DB00590,Doxazosin decreases standing and supine blood pressure and relieves the symptoms of benign prostatic hypertrophy through the inhibition of alpha-1 receptors.
DB00706,"Tamsulosin is an alpha adrenoceptor blocker with specificity for the alpha-1A and alpha-1D subtypes, which are more common in the prostate and submaxillary tissue."
DB01136,Carvedilol reduces tachycardia through beta adrenergic antagonism and lowers blood pressure through alpha-1 adrenergic antagonism
DB00960,Pindolol is a nonselective beta blocker indicated in the management of hypertension and prophylaxis of angina.
DB00887,Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure.
DB00925,Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma.
DB00964,Apraclonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters.
DB00384,"Triamterene, a relatively weak, potassium-sparing diuretic and antihypertensive,"
DB01012,Cinacalcet is a drug that acts as a calcimimetic (i.
DB00736,"Esomeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis,"
DB01159,Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia.
DB00350,Minoxidil is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance
DB00986,Glycopyrronium is a quaternary ammonium compound that is one of the most commonly prescribed long acting muscarinic antagonists.
DB01403,Methotrimeprazine is a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine
DB00191,"It is reported that the main mechanism of action of phentermine is the generation of appetite suppression,"
DB09289,Analyses in large-scale epidemiologic surveys have shown that the anxiety disorders are widely comorbid with major depression.
DB00388,"Phenylephrine is an alpha-1 adrenergic agonist that raises blood pressure, dilates the pupils,"
DB00830,Phenmetrazine is a sympathomimetic drug used primarily as an appetite depressant.
DB00205,"Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P."
DB01081,"Diphenoxylate, an antidiarrheal, is effective as adjunctive therapy in the management of diarrhea."
DB00698,"Nitrofurantoin interferes with vital processes in bacteria, which leads to their death."
DB03615,Ribostamycin is an aminoglycoside antibiotic isolated from _Streptomyces ribosidificus_ listed as one of the World Health Organization's critically important antimicrobials
DB01578,Metrizamide is a radiocontrast agent used to improve the contrast of internal body structures using different imaging techniques such as computed tomography scans (CT) or radiography (X-ray imaging)
DB00684,Tobramycin is an aminoglycoside antibiotic derived from the actinomycete _Streptomyces tenebrarius_.
DB00326,Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium
DB01349,"By blocking the angiotensin II (AT1) receptor, the drug ultimately causes vasodilation, reduced secretion of vasopressin (ADH),"
DB09285,"Morniflumate, given at therapeutic dosages to healthy human volunteers, on leukotriene B4 (LTB4) and thromboxane (TXB2) synthesis,"
DB01013,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
DB00732,Atracurium is a nondepolarizing skeletal muscle relaxant.
DB01226,"Mivacurium is a short-acting,"
DB00400,Griseofulvin is a mycotoxic metabolic product of <i>Penicillium spp
DB06203,Peak inhibition of DPP-4 occurs within 2-3 hours after a single-dose administration to healthy subjects.
DB06335,"Post-administration of saxagliptin, GLP-1 and GIP levels rise up to 2- to 3- fold."
DB00949,Felbamate is an antiepileptic indicated as monotherapy or as an adjunct to other anticonvulsants for the treatment of partial seizures resulting from epilepsy
DB01348,Spirapril is an angiotensin-converting enzyme (ACE) inhibitor.
DB05265,Ecabet is a prescription eye drop for the treatment of dry eye syndrome
DB06717,Fosaprepitant is a prodrug of Aprepitant.
DB00776,Oxcarbazepine is an anticonvulsant drug that reduces the incidence of seizures in epilepsy by inhibiting abnormal electrical activity in the brain
DB00982,The pharmacodynamics of isotretinoin are poorly understood
DB08899,Enzalutamide is a second-generation antiandrogen that blocks the activity of androgen and androgen receptor (AR) in prostate cancer
DB01656,"Roflumilast and its active metabolite, roflumilast N-oxide, increase cyclic adenosine-3′,"
DB12267,Brigitanib inhibits proliferation and in vitro viability of cells expressing the fusion protein EML4-ALK as well as 17 crizotinib-resistant ALK mutants.
DB09449,Sodium phosphate inceases fecal water content to increase mobility through the large intestine 
DB08822,"Pharmacodynamic effects of azilsartan medoxomil are mediated by its active metabolite, azilsartan."
DB09295,"Talniflumate is metabolized to its prodrug, niflumic acid, which has several pharmacodynamic effects."
DB00353,Methylergometrine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage.
DB00589,"There is evidence that lisuride lowers prolactin levels and, in low doses,"
DB00699,Nicergoline is a potent vasodilator (improves brain blood flow).
DB06207,Silodosin is an antagonist of α<sub>1</sub>-adrenoceptors.
DB06820,The function of imidazole derivatives can be attributed to their structural resemblance to purines essential to metabolism
DB00793,Used as a topical ointment or cream in the treatment of Tinea infections.
DB01422,Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections.
DB00646,Nystatin is an antifungal that is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi
DB00639,Butoconazole is an imidazole derivative that has fungicidal activity <i>in vitro</i> against <i>Candida</i> spp.
DB00937,Diethylpropion is a sympathomimetic stimulant drug marketed as an appetite suppressant.
DB00283,Clemastine is an antihistamine that also induces anticholinergic and sedative effects.
DB01296,"The administration of glucosamine, in theory, provides a building block towards the synthesis of glycosaminoglycans,"
DB00248,Cabergoline stimulates centrally-located dopaminergic receptors resulting in a number of pharmacologic effects.
DB01092,"Ouabain, a cardiac glycoside similar to digitoxin,"
DB00247,"Methysergide has been shown, <i>in vitro</i> and <i>in vivo</i>, to inhibit or block the effects of serotonin,"
DB01180,Used to treat hypertension.
DB06263,"The _anthracycline glycoside_ group of antibiotics, which includes amrubicin,"
DB00997,Doxorubicin is an antineoplastic in the anthracycline class
DB01172,Kanamycin is an aminoglycoside antibiotic.
DB00798,Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963.
DB06696,Arbekacin is an aminoglycoside.
DB01421,Paromomycin is a broad spectrum aminoglycoside antibiotic produced by <i>Streptomyces rimosus</i> var.
DB00452,Framycetin is used for the treatment of bacterial eye infections such as conjunctivitis.
DB00448,"Lansoprazole decreases gastric acid secretion by targeting H+,K+-ATPase, which is the enzyme that catalyzes the final step in the acid secretion pathway in parietal cells."
DB00955,"Netilmicin is a semisynthetic, water soluble antibiotic of the aminoglycoside group, produced by the fermentation of Micromonospora inyoensis, a species of actinomycete."
DB00656,Trazodone treats depressed mood and other depression-related symptoms and shows benefit in the treatment of insomnia due to its sedating effects.
DB01563,A hypnotic and sedative used in the treatment of insomnia.
DB01028,Methoxyflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia.
DB06716,"Fospropofol is a prodrug of propofol, a sedative hypnotic drug."
DB01463,Fencamfamine increases drive and mental alertness and an elevation of mood and a general feeling of well-being.
DB00405,In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils.
DB00404,"Alprazolam is a benzodiazepine that binds γ-aminobutyric acid (GABA) type-A receptors (GABA<sub>A</sub>Rs) to enhance their inhibitory effect on neurotransmission,"
DB01558,"Bromazepam is a lipophilic, long-acting benzodiazepine and with sedative, hypnotic, anxiolytic and skeletal muscle relaxant properties."
DB06594,Agomelatine resynchronises circadian rhythms in animal models of delayed sleep phase syndrome and other circadian rhythm disruptions
DB13323,"Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane,"
DB00721,"Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery."
DB01239,Chlorprothixene is a typical antipsychotic drug of the thioxanthine class.
DB00628,Clorazepate is a member of the group of drugs called benzodiazepines.
DB01624,Zuclopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics.
DB00490,The clinical effect of buspirone in alleviating the symptoms of generalized anxiety disorders typically takes 2 to 4 weeks to achieve
DB00186,The effect of lorazepam in GABA-A receptors produces an increase in the frequency of opening of the chloride ion channel.
DB00297,Bupivacaine is a widely used local anesthetic agent.
DB00645,Dyclonine is an oral anasthetic.
DB00391,Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist indicated to treat acute and chronic schizophrenia
DB01618,"Molindone is a dihydroindolone compound which is not structurally related to the phenothiazines, the butyrophenones,"
DB01086,Benzocaine is indicated for use as a topical anesthetic.
DB09166,"Etizolam is a CNS depressant with anxiolytic, anticonvulsant,"
DB06144,Sertindole is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia.
DB00385,Valrubicin is an anticancer agent.
DB00428,Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine
DB01253,Ergonovine belongs to the group of medicines known as ergot alkaloids.
DB00327,In clinical trials
DB01356,"Although lithium has been used for over 50 years in treatment of bipolar disorder,"
DB00854,Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
DB00890,Estrogens diffuse into their target cells and interact with a protein receptor.
DB00479,Amikacin is an aminoglycoside antibiotic.
DB06810,Plicamycin is lethal to Hela cells in 48 hours at concentrations as low as 0.
DB00919,Spectinomycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as S<i>treptomyces spectabilis</i>
DB00738,Pentamidine is an antiprotozoal agent.
DB01188,Ciclopirox is a broad-spectrum antifungal medication that also has antibacterial and anti-inflammatory properties.
DB00525,Tolnaftate is a synthetic over-the-counter anti-fungal agent
DB01157,"Trimetrexate, a non-classical folate antagonist, is a synthetic inhibitor of the enzyme dihydrofolate reductase (DHFR)."
DB09040,mean ± SD plasma Cmax on Day 28 of treatment: 0.
DB01153,Sertaconazole is an imidazole/triazole type antifungal agent.
DB01034,Cerulenin is an antifungal antibiotic isolated from <i>Cephalosporium caerulens</i>.
DB08958,A bactericidal and fungicidal antiseptic.
DB00864,Tacrolimus acts by reducing peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex.
DB01177,Idarubicin is an antineoplastic in the anthracycline class
DB06228,Rivaroxaban is an anticoagulant which binds directly to factor Xa.
DB01036,Tolterodine is a competitive muscarinic receptor antagonist.
DB04953,"As compared to other antiepileptic agents, ezogabine is unique in that it selectively activates potassium ion channels Kv 7."
DB00366,Doxylamine is an antihistamine commonly used as a sleep aid.
DB00334,"The effect of olanzapine in the D2 receptor is reported to produce the positive effects of this drug such as a decrease in hallucinations, delusions, disorganized speech,"
DB00408,"Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines."
DB06699,"Degarelix is a synthetic derivative of GnRH decapeptide, the ligand of the GnRH receptor."
DB01099,Flucytosine is an antimetabolite that acts as an antifungal agent with <i>in vitro</i> and <i>in vivo</i> activity against Candida and Cryptococcus.
DB06695,Dabigatran etexilate is a double prodrug that is hydrolyzed to the active by intestinal and hepatic carboxylesterases
DB00938,Salmeterol is a long acting beta-2 adrenergic receptor agonist that binds to both the active and exo sites of the beta-2 adrenergic receptor
DB01064,"Isoprenaline is a non-selective beta adrenergic receptor agonist used in a number of indications for the heart,"
DB09031,Little is known about the clinical pharmacodynamics of miltefosine and other antileishmanial drugs
DB00362,Anidulafungin is a semi-synthetic lipopeptide synthesized from a fermentation product of <i>Aspergillus nidulans</i>.
DB01007,Tioconazole is a broad-spectrum imidazole antifungal agent that inhibits the growth of human pathogenic yeasts.
DB03793,A fungistatic compound that is widely used as a food preservative.
DB00239,"Oxiconazole is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis,"
DB01406,"Danazol is a derivative of the synthetic steroid ethisterone, a modified testosterone."
DB04876,Vildagliptin works to improve glycemic control in type II diabetes mellitus by enhancing the glucose sensitivity of beta-cells (β-cells) in pancreatic islets and promoting glucose-dependent insulin secretion
DB04920,Clevidipine belongs to a well-known class of drugs called dihydropyridine calcium channel antagonists.
DB06412,"Oxymetholone is a synthetic anabolic steroid marketed under the brand name Anapolon by Hoffmann La Roche Limitedand used in the treatment of osteoporosis,"
DB01185,"Fluoxymesterone is a synthetic androgen, or male hormone,"
DB01141,"Formerly known as FK463,"
DB01243,"Chloroxine has an antibacterial action, inhibiting the growth of gram-positive as well as some gram-negative organisms."
DB00126,"Ascorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy."
DB04894,Vapreotide is a somatostatin analog with a higher metabolic stability than the parent hormone.
DB09183,Dasabuvir is classified as a direct-acting antiviral (DAA) and prevents viral replication in HCV genotype 1 
DB06767,Systemic acidifier.
DB01275,Hydralazine interferes with calcium transport to relax arteriolar smooth muscle and lower blood pressure.
DB01090,Pentolinium acts as a ganglionic blocking agent.
DB01214,"Metipranolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant,"
DB00940,"Methantheline is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder."
DB09300,Scopolamine butylbromide is a muscarinic antagonist which acts to prevent acetylcholine-stimulated contraction of smooth muscle in the gastrointestinal tract 
DB00747,"Scopolamine is an anticholinergic belladonna alkaloid that,"
DB00376,Trihexyphenidyl is an antimuscarinic indicated as an adjunct in the treatment of parkinsonism or as a treatment for drug-induced extrapyramidal symptoms
DB00979,Cyclopentolate is an anti-muscarinic in the same class as atropine and scopolamine.
DB00983,"Formoterol works locally in the lungs as a bronchodilator,"
DB00221,Isoetharine is a relatively selective beta2-adrenergic bronchodilator.
DB01409,Tiotropium is a long acting antimuscarinic that causes bronchodilation
DB00572,Atropine is an antimuscarinic agent that antagonizes the effects of acetylcholine.
DB08897,Aclidinium does not prolong the QTc interval or have significant effects on cardiac rhythm
DB12278,Propiverine hydrochloride inhibits abnormal contractions of bladder smooth muscle in vivo through not only its anticholinergic activity but also its concurrent calcium antagonistic activity .
DB00804,Dicyclomine is an anticholinergic drug used to relax the smooth muscles of the intestines
DB00867,"Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus."
DB01366,Procaterol is a long-acting beta-2-adrenergic receptor agonist.
DB11315,Methscopolamine bromide is an anticholinergic agent which possesses most of the pharmacologic actions of that drug class.
DB00424,"Hyoscyamine is not FDA approved, and so it has not official indications."
DB06702,"In-vivo the fesoteridine prodrug is broken down into its active metabolite, 5-hydroxymethyl tolterodine (5-HMT), by plasma esterases."
DB01338,Pipecuronium is a nondepolarizing neuromuscular blocking agent.
DB00392,"Ethopropazine, a phenothiazine and antidyskinetic, is used in the treatment of Parkinson's disease."
DB01173,"Orphenadrine is indicated as an adjunct to rest, physical therapy,"
DB00332,Ipratropium is a short-acting agent that inhibits the parasympathetic nervous system at the level of the airway which then produces bronchodilatation
DB00245,The inhibition of dopamine reuptake by benztropine produces a dose-dependent increase of dopamine in the nerve terminal of the dopaminergic system
DB01337,Pancuronium is a non-depolarising muscle relaxant similar to curare.
DB00340,Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties.
DB00219,"Oxyphenonium is an anticholinergic drug, a medication that reduces the effect of acetylcholine,"
DB00898,Alcohol produces injury to cells by dehydration and precipitation of the cytoplasm or protoplasm.
DB00871,Terbutaline is a beta-2 adrenergic receptor agonist indicated to treat reversibly bronchospasm in asthmatic patients with bronchitis and emphysema
DB00700,"Eplerenone, an aldosterone receptor antagonist similar to spironolactone,"
DB01339,The principal pharmacologic effects demonstrated by vecuronium revolve around its competitive binding of cholinergic receptors located at motor end plates
DB09076,Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD)
DB01062,"Oxybutynin exerts antispasmodic actions on the bladder, relieving the uncomfortable symptoms of overactive bladder, including urinary urgency and frequency."
DB00462,Methscopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic
DB00782,"Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine,"
DB00670,Pirenzepine belongs to a group of medications called antispasmodics/anticholinergics.
DB00809,Tropicamide is an anticholinergic drug and that works by non‐selectively blocking muscarinic receptors to cause mydriasis and cycloplegia.
DB00209,"Trospium is an antispasmodic, antimuscarinic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency."
DB00319,"Piperacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
DB01147,Cloxacillin is a semisynthetic antibiotic in the same class as penicillin.
DB00529,Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses <i>in vitro</i> including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2)
DB01604,Pivampicillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin.
DB00903,Ethacrynic acid is a monosulfonamyl loop or high ceiling diuretic.
DB01605,"Pivmecillinam is a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally,"
DB01061,"Similar to and ,"
DB00485,Dicloxacillin is a beta-lactamase resistant penicillin similar to oxacillin.
DB09324,"Sulbactam is a β-lactamase inhibitor given in combination with β-lactam antibiotics to inhibit β-lactamase,"
DB00361,Vinorelbine is a semi-synthetic vinca-alkaloid with a wide spectrum of anti-tumor activity.
DB00515,Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer
DB11613,Velpatasvir is a small molecule direct-acting antiviral used in the treatment of hepatitis C in combination with sofosbuvir.
DB03796,Palmitic acid is the first fatty acid produced during lipogenesis (fatty acid synthesis) and from which longer fatty acids can be produced
DB00512,"Vancomycin is a branched tricyclic glycosylated nonribosomal peptide often reserved as the ""drug of last resort"","
DB00713,"Oxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
DB01607,Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria.
DB00314,Capreomycin is a member of the aminoglycoside family of antibiotics.
DB08807,Bopindolol is a prodrug of pindolol
DB06715,It works in the thyroid gland.
DB01195,"Flecainide inhibits the action of sodium and potassium ion channels in the heart, raising the threshold for depolarization and correcting arrhythmias."
DB09570,In vitro studies have shown ixazomib to induce apoptosis in multiple myeloma cells sensitive or resistant to other conventional therapies.
DB00146,Calcidiol is the precursor of vitamin D3.
DB09296,Ombitasvir is classified as a direct acting antiviral and acts against HCV to inhibit viral replication 
DB01336,"Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant."
DB00565,The dose required to produce 95% suppression of twitch response to nerve stimulation (ED<sub>95</sub>) of cisatracurium is 0.
DB00892,Oxybuprocaine is a local anaesthetic.
DB00897,A short-acting benzodiazepine used as a hypnotic agent in the treatment of insomnia.
DB00750,Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell.
DB00842,"Benzodiazepines, including oxazepam, exert their sedative and anxiolytic effects by potentiating the effects of endogenous GABA, the primary inhibitory neurotransmitter in the CNS."
DB00962,Zaleplon is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia
DB00228,Enflurane rapidly induces anesthesia via the stimulation of inhibitory neural channels and the inhibition of excitatory neural channels.
DB00918,Almotriptan is a selective 5-hydroxytryptamine receptor subtype agonist indicated for the acute treatment of migraine attacks with or without aura in adults
DB00952,Naratriptan is a selective agonist of serotonin (5-hydroxytryptamine; 5-HT) type 1B and 1D receptors.
DB09072,"Sodium oxybate works to improve nocturnal sleep, improve alertness the following day,"
DB00409,Remoxipride is a weak selective dopamine D<sub>2</sub> receptor antagonist that was once used in the treatment of schizophrenia.
DB01215,"Estazolam, a triazolobenzodiazepine derivative, is an oral hypnotic agent with anticonvulsant, hypnotic,"
DB01353,Butethal (also known as butobarbitone and butobarbital) belongs to a group of medicines called the barbiturates
DB01161,Chloroprocaine is an ester local anesthetic agent indicated for the production of local or regional anesthesia with effects on the cardiovascular and central nervous systems.
DB08815,Lurasidone is a benzothiazol derivative that is an antagonist and binds with high affinity to Dopamine-2 (D2).
DB09042,Tedizolid is an oxazolidinone antibiotic that works by inhibiting protein synthesis by bacterial ribosomes.
DB00387,Procyclidine has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle.
DB00371,Meprobamate is an anxiolytic drug.
DB00237,Butabarbital potentiates GABAergic neurons while inhibiting neuronal acetylcholine and glutamate receptors to produce sedation.
DB09224,Melperone has been demonstrated to produce an antipsychotic effect at doses that cause minimal extrapyramidal symptoms frequently associated with more traditional antipsychotics 
DB00189,Ethchlorvynol is a sedative drug and schedule IV (USA) controlled substance.
DB00298,Dapiprazole is an alpha-adrenergic blocking agent.
DB08922,Perospirone is a serotonin 5-HT2 receptor inverse agonist and dopamine D2 receptor antagonist based on receptor binding experiments that binds to both receptors with high affinity
DB06216,"Asenapine is a serotonin, dopamine, noradrenaline,"
DB06288,Amisulpride is a selective dopamine D2 and D3 receptor antagonist with no affinity towards other dopamine receptor subtypes
DB01623,Thiothixene is an antipsychotic of the thioxanthene series.
DB00927,"Famotidine decreases the production of gastric acid, suppresses acid concentration and pepsin content, and decreases the volume of gastric secretion."
DB04842,Fluspirilene is a relatively long-acting injectable depot antipsychotic drug used for schizophrenia.
DB08941,A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
DB06152,"Nylidrin hydrochloride acts mainly by beta-receptor stimulation , ."
DB00723,Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure.
DB00819,"Acetazolamide is a potent carbonic anhydrase inhibitor,"
DB00211,"Midodrine is a prodrug, i."
DB06764,Tetryzoline is a sympathomimetic amine and an alpha-adrenergic agonist with vasoconstricting and decongestant properties
DB00142,"In addition to being one of the building blocks in protein synthesis,"
DB00875,Flupentixol is an antipsychotic agent with anxiolytic and mild sedative actions.
DB13025,Tiapride has a high degree of regional selectivity for limbic areas
DB00470,Dronabinol-induced sympathomimetic activity may result in tachycardia and/or conjunctival injection.
DB06016,Cariprazine is an antipsychotic agent.
DB01288,Fenoterol is a beta agonist designed to open up the airways to the lungs by decreasing bronchconstriction
DB01364,Ephedrine increases blood pressure by stimulating heart rate and cardiac output and variably increasing peripheral resistance.
DB00988,"Dopamine is a natural catecholamine formed by the decarboxylation of 3,"
DB01621,Pipotiazine has actions similar to those of other phenothiazines.
DB01365,Mephentermine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors.
DB06799,Ingestion of a 1-gram dose of methenamine hippurate produces antibacterial activity in the urine within 1/2 hour.
DB06148,"Mianserin is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect."
DB01235,Levodopa is able to cross the blood-brain barrier while dopamine is not
DB09225,"In preclinical studies,"
DB01255,Lisdexamfetamine dimesylate is a prodrug of _d-amphetamine_.
DB09209,"The therapeutic doses of pholcodine have been shown not to cause depression of respiration,"
DB09128,"Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors,"
DB00184,"Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain."
DB00170,Menadione (Vitamin K3) is a fat-soluble vitamin precursor that is converted into menaquinone in the liver.
DB00553,Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA).
DB00317,"Gefitinib inhibits the intracellular phosphorylation of numerous tyrosine kinases associated with transmembrane cell surface receptors,"
DB01219,Dantrolene is classified as a direct-acting skeletal muscle relaxant.
DB00909,"By stopping the spread of seizure discharges,"
DB04946,Iloperidone shows high affinity and maximal receptor occupancy for dopamine D2 receptors in the caudate nucleus and putamen of the brains of schizophrenic patients
DB00425,"**Effects on the central nervous system (CNS)**This drug has CNS depressant effects, which may include somnolence, decreased alertness, sedation, drowsiness, dizziness,"
DB00889,Granisetron is a selective inhibitor of type 3 serotonergic (5-HT<sub>3</sub>) receptors.
DB01074,Used in the treatment of unresponsive or refractory angina.
DB06292,Dapagliflozin inhibits the sodium-glucose contransporter 2(SGLT2) which is primarily located in the proximal tubule of the nephron
DB04572,The unstable nitrogen-carbon groups alkylate with DNA causing irrepairable DNA damage.
DB05109,Two of the rings in the drug's structure allows it to covalently bind to the minor groove of DNA
DB00762,Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer.
DB00307,Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs).
DB05381,"Histamine stimulates gastric gland secretion,"
DB00643,Mebendazole is a (synthetic) broad-spectrum anthelmintic.
DB01559,"Clotiazepam is a thienodiazepine possessing anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties."
DB08901,Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia.
DB00234,"Reboxetine is a selective noradrenaline reuptake inhibitor (NaRI), the first drug of new antidepressant class."
DB06654,Safinamide is for the treatment of parkinson's disease.
DB01424,"Aminophenazone exhibits analgesic, anti-inflammatory,"
DB00546,"Adinazolam is a benzodiazepine derivative used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia."
DB04835,Maraviroc is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5
DB12161,In clinical trials
DB00230,"Although the structure of pregabalin is similar to gamma-aminobutyric acid (GABA), it does not bind to GABA receptors."
DB01165,Ofloxacin is a quinolone/fluoroquinolone antibiotic.
DB08903,Bedaquiline is primarily subjected to oxidative metabolism leading to the formation of N-monodesmethyl metabolite (M2)
DB00308,"Ibutilide prolongs the action potential duration and increases both atrial and ventricular refractoriness in vivo, i."
DB01218,Halofantrine is a synthetic antimalarial which acts as a blood schizonticide.
DB01005,Hydroxyurea has dose-dependent synergistic activity with cisplatin <i>in vitro</i>.
DB06701,Dexmethylphenidate is the d-enantiomer of methylphenidate.
DB04938,The half maximal inhibitory concentration (IC50) for estrogen receptor (ER) alpha and beta are 0.
DB00494,"Entacapone is structurally and pharmacologically related to tolcapone, but unlike tolcapone,"
DB00757,"Dolasetron is a highly specific and selective serotonin 5-HT<sub>3</sub> receptor antagonist,"
DB01576,"Dextroamphetamine is a noncatecholamine, sympathomimetic amine that acts as a CNS stimulant."
DB00792,Used to treat the effects of colds and allergies.
DB09396,Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company.
DB06819,Phenylbutyric acid decreases elevated plasma ammonia glutamine levels in patients with urea cycle disorders.
DB01426,Ajmaline is a class 1A antiarrhythmic agent.
DB00222,Glimepiride stimulates the secretion of insulin granules from the pancreatic beta cells and improves the sensitivity of peripheral tissues to insulin to increase peripheral glucose uptake
DB09278,Activated charcoal is used as a gastric decontamination agent in emergency clinical settings in case of poison or medication overdose
DB01206,Lomustine is an alkylating agent of the nitrosourea type.
DB00888,"Mechlorethamine also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapeutic drug."
DB01008,Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer
DB00958,Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.
DB01042,Melphalan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer
DB00563,Methotrexate inhibits enzymes responsible for nucleotide synthesis which prevents cell division and leads to anti-inflammatory actions
DB00250,Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties
DB04841,Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity
DB12532,Oxetacaine improves common gastrointestinal symptoms
DB08872,"Since gabapentin enacarbil is a prodrug of gabapentin, it's physiological effects are the same as gabapentin."
DB11148,Butamben has been shown to selectively inhibit dorsal root pain signal transmission for periods of months when administered as epidural suspensions
DB06282,Levocetirizine is a second generation histamine H<sub>1</sub> antagonist used to treat various allergic symptoms.
DB01065,Melatonin is a hormone normally produced in the pineal gland and released into the blood.
DB04844,Prolongation of the QTc interval has been observed at doses of 50 mg.
DB08910,Pomalidomide is more potent than thalidomide (100-times) and lenalidomide (10-times)
DB00427,In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils.
DB01545,This compound belongs to the class of organic compounds known as alpha amino acid esters.
DB09352,Hydroxyamphetamine is a derivative of amphetamines.
DB00989,Rivastigmine is a parasympathomimetic and a reversible cholinesterase inhibitor
DB00517,Anisotropine methylbromide is a quaternary ammonium compound.
DB09017,Brotizolam is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog.
DB00801,"Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects."
DB01544,Flunitrazepam is a powerful hypnotic drug that is a benzodiazepine derivative.
DB00996,"Gabapentin is an anti-convulsant medication that inhibits the release of excitatory neurotransmitters,"
DB01588,"Prazepam is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant activity."
DB00998,Frovatriptan is a second generation triptan 5-HT receptor agonist that binds with high affinity for 5-HT<sub>1B</sub> and 5-HT<sub>1D</sub> receptors.
DB00704,"Naltrexone, a pure opioid antagonist,"
DB00683,**General effects**Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant.
DB01511,"Delorazepam is a benzodiazepine which, like other drugs in its class, possesses anxiolytic, skeletal muscle relaxant, hypnotic and anticonvulsant properties."
DB00916,"Metronidazole treats amebiasis, trichomoniasis, and giardiasis, exerting both antibacterial and antiprotozoal activities."
DB00218,Moxifloxacin is a quinolone/fluoroquinolone antibiotic.
DB00315,"Zolmitriptan, like other triptans, is a serotonin (5-hydroxytryptamine; 5-HT) receptor agonist,"
DB00967,Desloratadine is a long-acting second-generation H<sub>1</sub>-receptor antagonist which has a selective and peripheral H1-antagonist action
DB09068,Vortioxetine binds with high affinity to the human serotonin transporter.
DB09085,Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch
DB08987,Etidocaine is marketed under the name Duranest.
DB01325,Quinethazone is a thiazide diuretic used to treat hypertension.
DB00961,Mepivicaine is an amide local anesthetic.
DB00231,Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia .
DB00202,Succinylcholine's neuromuscular blockade takes effect within 60 seconds of intravenous administration and lasts between four to six minutes.
DB00241,"Butalbital is a short to intermediate-acting barbiturate that reversibly depresses the activity of excitable tissues,"
DB00423,Methacarbamol is a skeletal muscle relaxant with an unknown mechanism of action.
DB00906,Tiagabine is used primarily as an anticonvulsant for the adjunctive treatment of epilepsy.
DB01106,Levocabastine is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils
DB01202,"Levetiracetam appears to prevent seizure activity via the selective inhibition of hypersynchronized epileptiform burst firing without affecting normal neuronal transmission,"
DB00985,"Dimenhydrinate is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness."
DB01176,Cyclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent.
DB01501,Difenoxin acts as a potent antidiarrheal by slowing the movement of the intestines
DB00150,"Tryptophan is critical for the production of the body's proteins, enzymes and muscle tissue."
DB05246,Used in the treatment of epilepsy
DB00835,Brompheniramine is an antihistaminergic medication of the propylamine class.
DB01567,Fludiazepam is a benzodiazepine derivative.
DB01587,"Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA), which results in sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxant and amnesic action."
DB09009,Articaine is a dental local anesthetic.
DB00377,Palonosetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting
DB11699,Tropisetron is an indole derivative with antiemetic activity.
DB09041,"After a single dose, the mean (± standard deviation) peak concentration (Cmax) of tavaborole was 3."
DB01091,Butenafine is a synthetic antifungal agent that is structurally and pharmacologically related to allylamine antifungals.
DB01194,"Used in the treatment of glaucoma,"
DB06153,Various studies have shown pizotifen to be effective in the prophylaxis of migraines in reducing the frequency and severity of vascular headaches 
DB09345,"Pramocaine temporarily relieves pain, pruritis,"
DB00980,Ramelteon is the first selective melatonin agonist.
DB00445,Epirubicin is an antineoplastic in the anthracycline class
DB01082,"Although streptomycin originally had broad gram-negative and gram-positive coverage,"
DB01035,"Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation,"
DB01111,Colistimethate is a polymyxin antibiotic agent.
DB09090,Pinaverium is a selective and specific voltage-dependent calcium channel blocker located on intestinal smooth muscle cells to inhibit calcium influx
DB01427,"Amrinone is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity,"
DB00884,Risedronate is a pyridine-based bisphosphonate that inhibits bone resorption caused by osteoclasts
DB01627,Lincomycin is a lincosamide antibiotic derived as a natural fermentation product from _Streptomyces lincolnensis_.
DB00781,"Polymyxin B is an antibiotic that disrupts the outer cell membrane of Gram negative bacteria, binds and neutralizes lipopolysaccharide,"
DB06147,Sulfathiazole is a short-acting sulfa drug.
DB00660,"Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute,"
DB00455,"Like other 2nd generation antihistamines, loratadine is selective for peripheral H1 receptors."
DB00356,Chlorzoxazone is a centrally-acting agent for painful musculoskeletal conditions
DB01223,Aminophylline is the ethylenediamine salt of theophylline.
DB00251,Terconazole is a triazole antifungal agent available for intravaginal use.
DB00877,Sirolimus is an immunosuppressant drug with antifungal and antitumour effects.
DB00737,"Meclizine works on the higher centres of the brain to reduce nausea, vomiting, or vertigo."
DB00593,Used in the treatment of epilepsy
DB00181,Baclofen is an antispasmodic agent that induces muscle relaxation.
DB06770,Benzyl alcohol is an antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older
DB09099,"Somatostatin is an endogenous peptide hormone that is secreted by the central nervous system, gastrointestinal tract, retina,"
DB00165,"Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide,"
DB04908,Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015
DB00395,Carisoprodol is a centrally acting skeletal muscle relaxant that does not act directly on skeletal muscle but acts directly on the central nervous system (CNS)
DB01083,Orlistat helps with weight reduction and maintenance by inhibiting the absorption of dietary fats via the inhibition of lipase enzymes
DB08882,A 5mg oral dose of linagliptin results in >80% inhibition of dipeptidyl peptidase 4 (DPP-4) for ≥24 hours.
DB04794,Bifonazole is a type of antifungal medicine known as an imidazole.
DB00555,"Lamotrigine likely prevents seizures and prevents mood symptoms via stabilizing presynaptic neuronal membranes and preventing the release of excitatory neurotransmitters such as glutamate,"
DB00651,"Dyphylline, a xanthine derivative,"
DB09342,Propoxycaine is a local anesthetic which acts to decrease nerve impulses and therefore pain sensation during dental procedures 
DB00341,"**General effects and respiratory effects**Cetirizine, the active metabolite of the piperazine H<sub>1</sub>-receptor antagonist hydroxyzine, minimizes or eliminates the symptoms of chronic idiopathic urticaria, perennial allergic rhinitis,"
DB13872,Lormetazepam is a benzodiazepine which reduces central nervous system (CNS) activity .
DB01080,Vigabatrin is an antiepileptic agent chemically unrelated to other anticonvulsants.
DB08992,"Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia,"
DB00309,Vindesine is indicated for the treatment of acute lymphocytic leukemia of childhood that is resistant to vincristine and non-oat cell lung cancer
DB00434,"Cyproheptadine has been observed to antagonize several pharmacodynamic effects of serotonin in laboratory animals, including bronchoconstriction and vasodepression,"
DB08943,Isoconazole is an azole antifungal drug that has similar effectiveness to clotrimazole in the treatment of foot and vaginal infections
DB01205,Flumazenil antagonizes the CNS effects produced by benzodiazepines
DB00527,"Dibucaine is an amide-type local anesthetic,"
DB01210,"Levobunolol is an ophthalmic beta-blocker, equally effective at &beta;(1)- and &beta;(2)-receptor sites."
DB06791,"Lanreotide exhibits antisecretory effects through cAMP suppression,"
DB00817,Rosoxacin is a nonfluorinated quinolone antibiotic.
DB05316,Pimavanserin's unique actions on serotonin receptors improve symptoms of hallucinations and delusions associated with Parkinson's disease.
DB09223,Blonanserin antagonizes dopamine and serotonin receptors to reduce symptoms of schizophrenia 
DB00771,Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract
DB00650,"Leucovorin is one of several active, chemically reduced derivatives of folic acid."
DB00826,Natamycin is an antifungal drug for topical ophthalmic administration.
DB00604,"Cisapride is a parasympathomimetic which acts as a serotonin 5-HT<sub>4</sub> agonist; upon activation of the receptor signaling pathway,"
DB04861,"Nebivolol is a selective beta-1 adrenergic receptor antagonist that decreases vascular resistance, increases stroke volume and cardiac output,"
DB01113,Papaverine is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias
DB00568,Cinnarizine is an antihistamine and a calcium channel blocker.
DB11235,Thonzylamine is a first-generation antihistamine.
DB09488,Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever.
DB08799,Antazoline is a histamine H1 receptor antagonist.
DB04898,"Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary restrictions, drug interaction, and monitoring issues associated with the former."
DB01597,Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.
DB09230,Azelnidipine is a vasodilator that induces a gradual decrease in blood pressure in hypertensive patients.
DB06824,Triethylenetetramine (TETA) is a selective copper(II) chelator that works to promote urinary copper excretion.
DB09026,Aliskiren reduces blood pressure by inhibiting renin.
DB08808,"Bupranolol is a competitive,"
DB01359,"Penbutolol is a ß-1, ß-2 (nonselective) adrenergic receptor antagonist."
DB09034,Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal.
DB08931,Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA
DB06826,Unoprostone will begin to reduce IOP 30 minutes after ocular instillation
DB00765,"In patients with pheochromocytoma,"
DB02513,A phenol obtained from thyme oil or other volatile oils.
DB06718,"Stanozolol is a synthetic anabolic-androgenic steroid (AAS),"
DB09038,"Empagliflozin lowers blood glucose levels by preventing glucose reabsorption in the kidneys,"
DB00284,"Acarbose is a complex oligosaccharide that competitively inhibits the ability of brush-border alpha-glucosidase enzymes to break down ingested carbohydrates into absorbable monosaccharides,"
DB09083,"The funny channels (If) open during repolarization and close during depolarization,"
DB00823,Ethynodiol Diacetate is used as a female contraceptive.
DB06788,Histrelin inhibits gonadotropin secretion through the reversible down-regulation of gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and desensitization of the pituitary gonadotropes
DB00731,Insulin secretion by pancreatic β cells is partly controlled by cellular membrane potential
DB00331,**General effects**Insulin is an important hormone that regulates blood glucose levels.
DB01044,Gatifloxacin is a synthetic broad-spectrum 8-methoxyfluoroquinolone antibacterial agent for oral or intravenous administration
DB01261,"Sitagliptin inhibits DPP-4 which leads to increased levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), decreased levels of glucagon,"
DB01252,Mitiglinide belongs to the meglitinide class of blood glucose-lowering drugs.
DB04878,"Voglibose, an alpha-glucosidase inhibitor, is a synthetic compound with potent and enduring therapeutic efficacies against disorders of sensory,"
DB06402,"Telavancin is a semi-synthetic derivative of vancomycin, therefore the mode of bactericidal action is similar to vancomycin in which both antibiotics inhibit cell wall synthesis."
DB00672,"Chlorpropamide, a second-generation sulfonylurea antidiabetic agent,"
DB00166,Lipoic acid (or &alpha;-lipoic acid) is able to pass the blood-brain barrier and is putatively used for detoxification of mercury attached to the brain cells
DB00467,Enoxacin is a quinolone/fluoroquinolone antibiotic.
DB00627,"Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia,"
DB00491,"Miglitol, an oral alpha-glucosidase inhibitor, is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates,"
DB00912,Insulin secretion by pancreatic &beta; cells is partly controlled by cellular membrane potential
DB00827,"Cinoxacin is a synthetic antibacterial agent with <i>in vitro</i> activity against many gram-negative aerobic bacteria, particularly strains of the Enterobacteriaceae family."
DB01612,"Amyl nitrite, in common with other alkyl nitrites, is a potent vasodilator."
DB00592,"Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms,"
DB01030,"Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the <i>Camptotheca acuminata</i> tree),"
DB08911,"Trametinib is an anticancer agent which causes apoptosis (or programmed cell death) and inhibits cell proliferation,"
DB00856,Chlorphenesin is a muscle relaxant.
DB00419,"Miglustat, an N-alkylated imino sugar, is a synthetic analogue of D-glucose."
DB09134,The contrast enhancement obtained with ioversol is related to iodine content.
DB01249,"Iodixanol is a contrast agent commonly used during coronary angiography,"
DB00271,"Diatrizoate is the most commonly used water-soluble, iodinated, radiopaque x-ray contrast medium."
DB00914,"Used to treat diabetes,"
DB01295,Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension
DB01297,Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias.
DB01590,"Everolimus is a derivative of Rapamycin (sirolimus),"
DB00987,Cytarabine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute myelogenous leukemia and meningeal leukemia
DB00305,"Mitomycin is one of the older chemotherapy drugs, which has been around and in use for decades."
DB00120,Used by the brain to produce Norepinephrine
DB00480,"In hematological malignancies, the immune system is deregulated in the form of altered cytokine networks in the tumour microenvironment,"
DB00552,Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia
DB01280,Nelarabine is a prodrug of the cytotoxic deoxyguanosine analogue 9-&szlig;-D-arabinofuranosylguanine (ara-G).
DB00724,Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist
DB00970,"Generally, the actinomycins exert an inhibitory effect on gram-positive and gram-negative bacteria and on some fungi."
DB05260,"Gallium nitrate exerts hypocalcemic effect by inhibiting calcium resorption from bone, possibly by stabilizing bone matrix,"
DB09117,Paraldehyde blocks neuromuscular transmission 
DB00953,Rizatriptan is a selective agonist of serotonin (5-hydroxytryptamine; 5-HT) type 1B and 1D receptors
DB00216,Eletriptan is a selective 5-hydroxytryptamine 1B/1D receptor agonist.
DB00743,Gadobenate dimeglumine shares the pharmacokinetic properties of the ECF contrast agent gadopentetate dimeglumine; however
DB06698,"Through its actions on the histamine receptors,"
DB01489,"Camazepam is a benzodiazepine which is a dimethyl carbamate ester of tamzepam, a metabolite of diazepam."
DB01068,"The pharmacodynamic properties of clonazepam are common among benzodiazepines and include anticonvulsive, sedative,"
DB00441,Gemcitabine is a nucleoside analog that mediates its antitumour effects by promoting apoptosis of malignant cells undergoing DNA synthesis.
DB00928,Azacitidine is believed to exert its antineoplastic effects by causing hypomethylation of DNA and direct cytotoxicity on abnormal hematopoietic cells in the bone marrow
DB00444,"Teniposide is a phase-specific cytotoxic drug,"
DB01262,"Decitabine is a prodrug analogue of the natural nucleotide 2’-deoxycytidine, which, upon being phosphorylated intracellularly,"
DB00488,Altretamine is a novel antineoplastic agent.
DB01117,Atovaquone is a highly lipophilic drug that closely resembles the structure .
DB00664,Sulfametopyrazine is a sulfonamide antibiotic.
DB00746,"Deferoxamine, otherwise known as desferrioxamine or desferal,"
DB01184,Domperidone is a specific blocker of dopamine receptors.
DB09071,Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD).
DB11586,Studies in vitro demonstrated a significant antiviral activity in HCV replicon cell systems with an EC50 of 4nm and 1nm against the HCV genotype 1a and 1b respectively
DB01181,Ifosfamide requires activation by microsomal liver enzymes to active metabolites in order to exert its cytotoxic effects
DB01394,Colchicine reduces the pain resulting from gout and reduces flares of Familial Mediterranean fever by interfering with inflammatory pathways.
DB00990,Aromatase is an enzyme that converts hormones to estrogen in the body's adrenal glands
DB00357,"Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens,"
DB09274,"Artesunate is an artemisinin derivative that is metabolized to DHA,"
DB09078,Based on x-ray crystallography and kinetic interaction studies
DB01299,Sulfadoxine helps inhibit the enzyme dihydropteroate synthetase which is an enzyme necessary in the conversion of PABA to folic acid.
DB09231,Benidipine reduces systolic and diastolic blood pressure as well as to present decreases in heart rate pulse after treatment
DB06145,The absolute bioavailability of oral spiramycin is generally within the range of 30 to 40%.
DB01070,"Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol,"
DB00153,"After the activation of the vitamin D receptor,"
DB11156,"It has similar properties to both competitive and depolarizing neuromuscular blocking agents,"
DB00550,Propylthiouracil is a thiourea antithyroid agent.
DB01135,"Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant."
DB00910,Secondary hyperparathyroidism is characterized by an elevation in parathyroid hormone (PTH) associated with inadequate levels of active vitamin D hormone
DB00773,Etoposide is an antineoplastic agent and an epipodophyllotoxin (a semisynthetic derivative of the podophyllotoxins).
DB00541,"Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma,"
DB00836,Loperamide is an anti-diarrheal agent that provides symptomatic relief of diarrhea.
DB08874,"Fidaxomicin has a narrow-spectrum antibacterial profile, with potent bactericidal activity specifically against C."
DB06616,Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML).
DB00027,Gramicidin is particularly effective against gram-positive bacteria.
DB01011,Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis
DB00481,Raloxifene belongs to the selective estrogen receptor modulator (SERM) drug class that exhibits estrogenic effects on bone and lipid metabolism while mediating anti-estrogenic effects on uterine endometrium and breast tissues
DB01369,"Quinupristin is a streptogramin antibiotic, derived from pristinamycin I."
DB00518,Albendazole is a broad-spectrum anthelmintic.
DB05294,Mean IC50 of approximately 2.
DB00845,Clofazimine exerts a slow bactericidal effect on <i>Mycobacterium leprae</i> (Hansen's bacillus) due primarily to its action on the bacterial outer membrane
DB01051,Novobiocin is an aminocoumarin antibiotic that was produced by the actinomycete <i>Streptomyces niveus</i>.
DB08806,Roxatidine acetate suppresses the effect of histamine on the parietal cells of the stomach (H2-receptor antagonist).
DB12001,"In combination with fulvestrant, the progression-free survival for patients with HR-positive, HER2-negative breast cancer was 16."
DB09462,Glycerin is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects; it may also have lubricating and fecal softening actions
DB01204,"Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa,"
DB02659,A major primary bile acid produced in the liver and usually conjugated with glycine or taurine.
DB01183,Naloxone is an opioid receptor antagonist indicated in the reversal of opioid overdoses.
DB00504,"Levallorphan, an opioid antagonist similar to naloxone, is used to treat drug overdoses."
DB12070,Letermovir inhibits the activity of the DNA terminase complex of CMV thereby preventing the cutting of viral DNA into mature length genomes for packaging into viral particles 
DB13878,Pibrentasvir is a pan-genotypic .
DB01190,Clindamycin exerts its bacteriostatic effect via inhibition of microbial protein synthesis.
DB01093,"Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities."
DB09055,Acipimox is a niacin derivative used as a hypolipidemic agent.
DB06774,Capsaicin is a TRPV1 receptor agonist.
DB00973,"Ezetimibe was shown to reduce the levels of total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apoprotein B (Apo B), non-high-density lipoprotein cholesterol (non-HDL-C),"
DB01138,Sulfinpyrazone's pharmacologic activity is the potentiation of the urinary excretion of uric acid
DB08811,"Like other benzodiazepines, tofisopam possesses anxiolytic properties but unlike other benzodiazepines it does not have anticonvulsant, sedative, skeletal muscle relaxant,"
DB01071,In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils.
DB01217,Anastrozole prevents the conversion of adrenal androgens (e.
DB00882,"Clomifene (previously clomiphene) is an orally administered, non steroidal, ovulatory stimulant that acts as a selective estrogen receptor modulator (SERM)."
DB01301,A pyrrolidinylmethyl tetracycline.
DB00900,Didanosine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
DB01273,"Varenicline is a partial nicotinic acetylcholine receptor agonist,"
DB08930,HIV-1 infected subjects on dolutegravir monotherapy demonstrated rapid and dose-dependent reduction of antiviral activity with declines of HIV-1 RNA copies per ml
DB00778,"Roxithromycin has the following antibacterial spectrum <i>in vitro</i>: <i>Streptococcus agalactiae</i>, <i>Streptococcus pneumoniae</i> (Pneumococcus), <i>Neisseria meningitides</i> (Meningococcus), <i>Listeria monocytogenes</i>, <i>Mycoplasma pneumoniae</i>, <i>Chlamydia trachomatis</i>, <i>Ureaplasma urealyticum</i>, <i>Legionella pneumophila</i>, <i>Helicobacter</i> (Campylobacter),"
DB00585,"Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells."
DB11633,"Isavucoanzole exhibits antifungal activity against most strains of _Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger_,"
DB06817,Raltegravir is an antiretroviral drug produced by Merck & Co.
DB00759,Tetracycline is a short-acting antibiotic that inhibits bacterial growth by inhibiting translation
DB01085,Pilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound.
DB09027,Ledipasvir acts against HCV and is categorized as a direct-acting antiviral agent (DAA).
DB08909,Glycerol phenylbutyrate prolongs the QTc interval
DB06742,Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus.
DB00719,"Azatadine is an antihistamine, related to cyproheptadine, with anti-serotonin, anticholinergic (drying), and sedative effects."
DB05015,"Beleodaq is a histone deacetylase (HDAC) inhibitor that exhibits pan-HDAC inhibition and potent growth inhibitory and pro-apoptotic activities in a variety of tumor cells,"
DB00665,Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer.
DB00360,"Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine,"
DB09343,"Tipiracil prevents trifluridine conversion into 5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione, which is an inactive major metabolite, by inhibiting the enzyme thymidine phosphorylase."
DB06480,"In animal studies,"
DB00577,"**Antiviral effects**Valacyclovir shows varying levels of inhibition towards herpes simplex virus types 1 (HSV-1), 2 (HSV-2), Varicella Zoster Virus (VZV), Epstein-Barr virus (EBV),"
DB01586,Ursodiol (commonly known as ursodeoxycholic acid) is a product of metabolism of bacteria in the intestine.
DB00158,"Folic acid is a water-soluble B-complex vitamin found in foods such as liver, kidney, yeast, and leafy, green vegetables."
DB01345,"Potassium is the major cation (positive ion) inside animal cells,"
DB09321,"Zinc oxide has astringent, soothing and protective properties and is used in topical preparations for eczema, slight excoriations,"
DB00459,Acitretin is a retinoid.
DB00523,Alitretinoin (9-<i>cis</i>-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma
DB08867,"Ulipristal is a selective, reversible progestin receptor modulator and its tissue targets include the uterus, cervix, ovaries,"
DB06410,"Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring,"
DB00302,Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin.
DB09210,"Piracetam is known to mediate various pharmacodynamic actions:**Neuronal effects**: Piracetam modulates the cholinergic, serotonergic,"
DB09101,Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults
DB01140,"Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis,"
DB00456,Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally
DB00609,Ethinamate is bacteriostatic against <i>M.
DB01764,"Dalfopristin is a streptogramin antibiotic,"
DB00634,Sulfacetamide is a sulfonamide antibiotic with bacteriostatic actions and broad-spectrum activity against most gram-positive and many gram-negative organisms.
DB12924,Although the exposure response relationship for ozenoxacin after it has been applied topically has not yet been studied
DB06219,The antibacterial activity of dalbavanci
DB00410,"Mupirocin is reported to be active against susceptible aerobic gram-positive cocci, such as _Staphylococcus aureus_, _Staphylococcus epidermidis_,"
DB00330,Ethambutol is indicated in combination with other anti-tuberculosis drugs in the treatment of pulmonary tuberculosis.
DB00760,Meropenem is a broad-spectrum carbapenem antibiotic.
DB00430,Cefpiramide is a cephalosporin active against <i>Pseudomonas aeruginosa</i>.
DB00260,"Cycloserine, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic,"
DB00535,Cefdinir is a bactericidal agent that treats bacterial infections by interfering with cell wall synthesis.
DB00828,"Although used primarily to treat urinary tract infections,"
DB09047,Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus
DB00162,Vitamin A is effective for the treatment of Vitamin A deficiency
DB06706,Isometheptene Mucate is an indirect-acting sympathomimetic.
DB06795,Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns.
DB04854,"Febuxostat is a novel, selective xanthine oxidase/dehydrogenase inhibitor that works by decreasing serum uric acid in a dose-dependent manner."
DB09257,"Gimeracil is an adjunct to antineoplastic therapy,"
DB01004,Ganciclovir is a synthetic nucleoside analogue of 2'-deoxyguanosine that inhibits replication of herpes viruses both <i>in vitro</i> and <i>in vivo</i>.
DB00811,Ribavirin mediates direct antiviral activity against a number of DNA and RNA viruses by increasing the mutation frequency in the genomes of several RNA viruses
DB01436,"Alfacalcidol works to increase serum levels of calcium by stimulating intestinal calcium absorption, reabsorption of calcium from bone,"
DB00256,"Lymecycline, like other tetracyclines, exerts bacteriostatic actions on intracellular and extracellular bacteria,"
DB00495,Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
DB00499,Flutamide is a nonsteroidal antiandrogen.
DB00666,Nafarelin is a potent agonistic analog of gonadotropin-releasing hormone (GnRH).
DB11256,Levomefolic acid is an active metabolite of folic acid and a methyl group donor in one-carbon metabolism reactions.
DB11596,Levoleucovorin is actively and passively transported across cell membranes.
DB06274,Alvimopan is a peripherally acting μ opioid antagonist.
DB09049,Use of opioids induces slowing of gastrointestinal motility and transit.
DB06813,"Pralatrexate is a folate analog that inhibits folate metabolism, thus impeding the synthesis of amino acids and nucleic acid."
DB00460,"Verteporfin,"
DB11268,"Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S."
DB00720,Clodronic acid is a first generation bisphosphonate that inhibits osteoclast mediated bone resorption
DB00630,Alendronic acid tablets have a very low oral bioavialability.
DB09138,Technetium (99mTc) medronic acid is a pharmaceutical product used in nuclear medicine imaging.
DB00282,Pamidronic acid is a second generation
DB01077,"Etidronic acid is a first generation bisphosphonate that inhibits the action of osteoclasts,"
DB00035,By mimicking the actions of endogenous ADH
DB01133,Tiludronic acid is a bisphosphonate that prevents osteoclasts from resorbing bone.
DB00399,"Zoledronic acid is a third generation,"
DB04865,The pharmacodynamics of homoharringtonine is not fully understood.
DB01160,Dinoprost tromethamine is the tromethamine (THAM) salt of the naturally occurring prostaglandin F2<sub>alpha</sub>.
DB00917,Dinoprostone is equivalent to prostaglandin E2 (PGE2).
DB01046,Chronic idiopathic constipation is generally defined by infrequent or difficult passage of stool.
DB11660,Upon applying an appropriate dose of latanoprost bunod
DB08819,Tafluprost is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α
DB00929,Misoprostol is a prostaglandin E1 analog used to reduce the risk of NSAID induced gastric ulcers by reducing secretion of gastric acid from parietal cells
DB08964,Gemeprost softens and dilates of the cervix prior to transcervical intrauterine operative procedures
DB00429,Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy
DB04571,Trioxsalen ispharmacologically inactive but when exposed to ultraviolet radiation or sunlight it is converted to its active metabolite to produce a beneficial reaction affecting the diseased tissue
DB00855,The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis.
DB09536,"Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium."
DB01878,Benzophenone is the organic compound.
DB00140,"Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health."
DB01414,Cefacetrile is effective against many Gram-positive bacterial strains and somewhat less effective against Gram-negative species.
DB00229,Cefotiam is a third generation beta-lactam cephalosporin antibiotic that works by inhibiting bacterial cell wall biosynthesis
DB00583,Levocarnitine is a carrier molecule in the transport of long chain fatty acids across the inner mitochondrial membrane
DB01603,"Meticillin (INN, BAN) or methicillin (USAN) is a narrow spectrum beta-lactam antibiotic of the penicillin class."
DB01327,Cefazolin (also known as cefazoline or cephazolin) is a semi-synthetic first generation cephalosporin for parenteral administration.
DB01326,The parenteral prodrug formate ester cefamandole nafate is a broad-spectrum cephalosporin antibiotic.
DB01331,Cefoxitin is a cephamycin antibiotic often grouped with the second-generation cephalosporins.
DB06713,Norelgestromin is used for contraception and menopausal hormonal therapy transdermally or in combination with ethinyl estradiol as a vaginal ring.
DB09389,Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception.
DB06176,Romidepsin is a selective inhibitor of histone deacetylase
DB00560,Tigecycline is the first clinically-available drug in a new class of antibiotics called the glycylcyclines.
DB08916,"Aberrant ErbB signaling triggered by receptor mutations, and/or amplification,"
DB01191,"Used to treat diabetes and obesity, Dexfenfluramine decreases caloric intake by increasing serotonin levels in the brain&rsquo;s synapses."
DB06691,"Mepyramine, or pyrilamine, targets the H1 receptor."
DB06217,Vernakalant blocks currents in all phases of atrial action potential including atria-specific potassium currents (the ultra-rapid delayed rectifier and the acetylcholine dependent potassium currents) and prolongs the refractory period
DB11994,Decreases inflammation and cartilage destruction and also corrects altered osteoblast acitivity 
DB06800,Use of opioids induces slowing of gastrointestinal motility and transit.
DB08869,"Tesamorelin stimulates growth hormone secretion,"
DB13747,Acts as a surfactant or alkalizing agent
DB11610,Oxilofrine is a sympathomimetic which increases adrenergic activity 
DB00411,Carbamoylcholine is a parasympathomimetic that acts as an agonist of muscarinic and nicotinic receptors
DB00718,Adefovir dipivoxil a diester prodrug of adefovir.
DB00369,Cidofovir is a new anti-viral drug.
DB00339,Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB).
DB00380,Dexrazoxane is a cardioprotective agent 
DB01575,Kaolin is an adsorptive agent.
DB00859,Penicillamine is a chelating agent used in the treatment of Wilson's disease.
DB00728,Neuromuscular blocking agents are drugs that cause skeletal muscle relaxation primarily by causing a decreased response to the neurotransmitter acetylcholine (ACh) at the myoneural (neuromuscular) junction of skeletal muscle
DB13450,"Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available in its salt form,"
DB09153,"Sodium, the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance,"
DB01063,Acetophenzine is a phenothiazine antipsychotic intended for the management of schizophrenia and other psychotic disorders
DB09018,Bromopride is a dopamine antagonist used as an antiemetic.
DB09097,Quinagolide achieves long-lasting reduction in prolactin levels in a dose-proportional effect via selectively targeting D2 receptors as an agonist
DB01213,"Fomepizole is a competitive inhibitor of alcohol dehydrogenase,"
DB01006,Letrozole is an aromatase inhibitor used in the treatment of breast cancer.
DB00969,Alosetron is a potent and selective antagonist of the serotonin 5-HT<sub>3</sub> receptor type.
DB00911,Tinidazole is a synthetic antiprotozoal agent.
DB04845,Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug.
DB11574,"Elbasvir is classified as a direct-acting antiviral (DAA) and prevents viral replication in HCV genotypes 1a, 1b,"
DB08932,Macitentan acts primarily by reducing vasoconstriction and cell proliferation due to endothelin overexpression
DB01256,Retapamulin is a semisynthetic pleuromutilin antibiotic.
DB09555,"In allergic reactions,"
DB11817,Baricitinib is a disease-modifying antirheumatic drug (DMARD) used to ameliorate symptoms and slow down the progression of rheumatoid arthritis.
DB09297,At concentrations approximately 6 and 1.
DB11575,"Grazoprevir is classified as a direct-acting antiviral (DAA) and prevents viral replication in HCV genotypes 1a, 1b,"
DB05541,Brivaracetam binds SV2A with high affinity .
DB11737,"In vitro: Icotinib inhibits EGFR activity in a dose-dependent manner, with an IC50 value of 5 nM and complete inhibition at 62."
DB00136,"Calcitriol is a biologically active calcitrophic hormone with anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities."
DB04930,"Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites,"
DB00617,Paramethadione is an oxazolidinedione anticonvulsant similar to trimethadione that acts on the central nervous system (CNS) to reduce the number of absence seizures (often seen in epileptics)
DB00347,Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications
DB01105,Sibutramine is an orally administered agent for the treatment of obesity.
DB11828,"Neratinib is a tyrosine kinase inhibitor which exhibits antitumor action against Epidermal Growth Factor Receptor (EGFR), HER2,"
DB11614,"Rupatadine is an anti allergenic and acts to reduce allergic symptoms like urticaria, rhinorrhea,"
DB01216,Finasteride is an antiandrogenic compound that works by suppressing the production of serum and intraprostatic dihydrotestosterone (DHT) in men via inhibiting the enzyme responsible for the biosynthesis of DHT
DB00947,Fulvestrant for intramuscular administration is an estrogen receptor antagonist without known agonist effects
DB00943,Zalcitabine is an analog of 2'-deoxycytidine that is pharmacologically related to but structurally different from other nucleotide reverse transcriptase inhibitors (NRTIs)
DB11581,"Venetoclax induces rapid and potent onset apoptosis of CLL cells, powerful enough to act within 24h and to lead to tumor lysis syndrome , ,"
DB00426,Famciclovir is a prodrug that undergoes rapid biotransformation to the active antiviral compound penciclovir
DB01179,"Podofilox, also called podophyllotoxin,"
DB00185,Cevimeline is a cholinergic agonist which binds to muscarinic receptors.
DB06777,"It acts by reducing levels of cholesterol in the bile,"
DB11915,Valbenazine decreases the availability of monoamine neurotransmitters by preventing their storage in synaptic vesicles 
DB12483,Copanlisib has demonstrated potent anti-tumor and pro-apoptotic activity in various tumor cell lines and xenograft models .
DB00853,Temozolomide is a prodrug of the imidazotetrazine class that requires nonenzymatic hydrolysis at physiological pH _in vivo_ to perform alkylation of adenine/guanine residues
DB01423,The drug promotes drainage of mucus from
DB00352,Thioguanine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia
DB01073,Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia.
DB00262,Carmustine is one of the nitrosoureas indicated as palliative therapy as a single agent or in established combination therapy with other approved chemotherapeutic agents in treatment of brain tumors
DB08908,The physiological effects of dimethyl fumarate on the body are not well understood.
DB00242,Cladribine is a synthetic purine nucleoside that acts as an antineoplastic agent with immunosuppressive effects
DB11989,"Benznidazole is a trypanocidal agent which kills the causative organism in Chagas disease,"
DB00291,Chlorambucil is an antineoplastic in the class of alkylating agents that is used to treat various forms of cancer
DB00290,Bleomycin is an antibiotic which has been shown to have antitumor activity.
DB00851,Dacarbazine is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC).
DB08798,Sulfamoxole is a sulfonamide antibiotic.
DB01298,Sulfacytine is a short-acting sulfonamide.
DB01581,"Sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthetase (DHPS),"
DB00562,Benzthiazide is used to treat hypertension and edema.
DB00576,Sulfamethizole is a sulfonamide antibiotic.
DB08796,Antitussive agents act centrally on the medullary cough center
DB01284,Cosyntropin exhibits the full corticosteroidogenic activity of natural ACTH
DB00190,"When mixed with ,"
DB06766,"Following bilateral topical ocular administration of alcaftadine ophthalmic solution, 0."
DB08967,Dimetotiazine has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions
DB00354,Buclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent.
DB08802,"Isothipendyl, an azaphenothiazine derivative, competitively binds to histamine (H1) receptors, resulting in inhibition of the pharmacological effects of histamines."
DB01620,"Pheniramine acts as an antagonist to allergic symptoms stemming from inappropriate histamine release to reduce edema, itching,"
DB08800,Chlorpyramine is a competitive reversible H1 receptor antagonist.
DB00885,Pemirolast is used for the prophylactic treatment of itching of the eye associated with allergic conjunctivitis
DB08801,Dimethindene occurs as a racemic mixture.
DB01619,Phenindamine is an antihistamine.
DB00978,"Lomefloxacin is a fluoroquinolone antibiotic used to treat chronic bronchitis,"
DB00787,Acyclovir is a nucleoside analog that inhibits the action of viral DNA polymerase and DNA replication of different herpesvirus
DB05990,"The activation of the FXR by obeticholic acid acts to reduce the synthesis of bile acids, inflammation,"
DB00303,Ertapenem is a carbapenem antibiotic drug that is marketed under the trade name Invanz by Merck & Co.
DB01598,Imipenem is a beta-lactam antibiotic belongings to the subgroup of carbapenems
DB06211,Similar to other beta-lactam antimicrobial agents
DB01089,"Deserpidine, an alkaloid of <i>Rauwolfia canescens</i>, is used as an antihypertensive."
DB01613,Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin
DB06403,Ambrisentan 10 mg daily had no significant effect on the QTc interval
DB11943,Delafloxacin is a fluoroquinolone antibacterial drug which kills bacterial cells 
DB09135,As with other iodinated contrast agents the degree of contrast enhancement is directly related to the iodine content in the administered dose
DB04711,"Following intravenous administration of Cholografin Meglumine,"
DB01362,"Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography,"
DB09156,"Iopromide is a low osmolar,"
DB08947,"Iopamidol is a contrast agent developed by Bracco with nonionic,"
DB00642,"Pemetrexed inhibited the in vitro growth of mesothelioma cell lines (MSTO-211H, NCI-H2052) and showed synergisticeffects when combined with cisplatin."
DB06769,No mean changes in QTc interval greater than 20 milliseconds were detected up to one hour post-infusion
DB08889,Intravenous carfilzomib administration resulted in suppression of proteasome chymotrypsin-like activity when measured in blood 1 hour after the first dose.
DB00293,Raltitrexed belongs to a group of medicines known as antimetabolites.
DB08828,Vismodegib selectively binds to and inhibits the transmembrane protein Smoothened homologue (SMO) to inhibit the Hedgehog signalling pathway
DB01094,Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices.
DB09272,"Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D)."
DB00134,L-Methionine is a principle supplier of sulfur which prevents disorders of the hair
DB00832,Phensuximide suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in absence (petit mal) seizures
DB00730,Thiabendazole is a fungicide and parasiticide.
DB01610,Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.
DB01438,Phenazopyridine acts as a local anesthetic offering relief from irritating conditions of the urinary tract.
DB06782,"Due to its oily nature,"
DB00769,Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses
DB06202,"Lasofoxifene exhibits both significant estrogenic and antiestrogenic activity both in vitro and in vivo, targeting any tissues that possess ERs, such as bone, uterus, breast, blood vessels,"
DB06401,"Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals."
DB09096,Benzoyl peroxide is a topical treatment for acne that generates free radicals to break down comedones and increase the rate of epithelial cell turnover
DB08934,Sofosbuvir acts against HCV and is categorized as a direct-acting antiviral agent (DAA).
DB01412,"Theobromine, a xanthine derivative like caffeine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic,"
DB11106,"Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline."
DB09338,Mersalyl acid is an organomercuric compound.
DB01294,"Bismuth subsalicylate is an antacid and antimicrobial, gastroprotective, anti-secretory, and anti-inflammatory actions."
DB00152,"Thiamine is a vitamin with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities."
DB11135,Selenium is incorporated into many different selenoproteins which serve various functions throughout the body 
DB09322,"Zinc has been identified as a cofactor for over 70 different enzymes, including alkaline phosphatase, lactic dehydrogenase and both RNA and DNA polymerase."
DB11239,"Aluminum sulfate may be used as a deodorant, as well as an astringent ."
DB11342,Aluminum oxide has a chemical formula Al2O3.
DB11136,"Trivalent chromium is part of glucose tolerance factor, an essential activator of insulin-mediated reactions."
DB00355,Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from <i>Chromobacterium violaceum</i>
DB06827,Viomycin is a tuberactinomycin antibiotic that was used to treat Mycobacterium tuberculosis until it was replaced by the less toxic capreomycin
DB06771,Besifloxacin tear concentrations were higher than MIC90 (minimum inhibitory concentration) values for common bacterial pathogens and sustained for 24 hours or longer.
DB08965,"Fusafungine is an antibiotic from Fusarium lateririum,"
DB00954,Dirithromycin is a pro-drug which is converted non-enzymatically during intestinal absorption into the microbiologically active moiety erythromycylamine
DB01415,Ceftibuten is an antibiotic with bactericidal actions
DB00803,Colistin is a polymyxin antibiotic agent.
DB00626,Bacitracin is a mixture of polypeptides that prevent the formation of the bacterial cell wall and oxidatively cleave DNA
DB09499,"Sodium thiosulfate doses of 20, 15 and 10 g/m deliver sodium loads of 162, 121 and 81 mmol/m."
DB01150,"Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections,"
DB00080,Daptomycin is a cyclic lipopeptide antibacterial agent produced as a fermentation product by the soil microbe _Streptomyces roseosporus_.
DB00595,Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections.
DB04570,Latamoxef works by inhibiting bacterial cell wall biosynthesis
DB09060,Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz).
DB00649,Stavudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
DB00709,Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV) to disrupt viral DNA synthesis.
DB00122,This compound is needed for good nerve conduction throughout the CNS (central nervous system) as it is a precursor to acetylcholine (ACh).
DB00931,Methacycline is a tetracycline antibiotic.
DB00453,Clomocycline is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne.
DB11641,The antitumour effects of vinflunine are dependent on concentration and exposure duration of the drug 
DB11691,Naldemedine is an opioid receptor antagonist with restricted movement across the blood brain barrier 
DB02300,Calcipotriene is a synthetic analog of vitamin D.
DB00130,"Like other amino acids, glutamine is biochemically important as a constituent of proteins."
DB09130,Copper is incorporated into many enzymes throughout the body as an essential part of their function .
DB09290,"Ramosetron is a _serotonin 5-HT3 receptor antagonist_ commonly employed to treat nausea and vomiting,"
DB00761,The potassium ion is in the principle intracellular cation of most body tissues.
DB01121,"Phenacemide is a ureal anticonvulsant indicated for control of severe epilepsy, particularly mixed forms of complex partial (psychomotor or temporal lobe) seizures,"
DB00740,"Riluzole, a member of the benzothiazole class, is indicated for the treatment of patients with amyotrophic lateral sclerosis (ALS)."
DB06218,Lacosamide therapy is correlated with a decrease in seizure frequency.
DB04339,"Due to its mucolytic effects, carbocisteine significantly reduces sputum viscosity, cough, dyspnea and fatigue."
DB00561,Doxapram is an analeptic agent (a stimulant of the central nervous system)
DB06709,"Methacholine is a non-specific cholinergic agonist (parasympathomimetic) that acts through muscarinic receptors in the lungs to induce bronchoconstriction, which is more significant in patients with asthma than those without."
DB01019,Bethanechol is selective for muscarinic receptors and has little to no impact on nicotinic receptors
DB03128,A neurotransmitter.
DB01228,"Used to treat irregular heartbeats, encainide decreases excitability, conduction velocity, and automaticity as a result of slowed atrial, atrioventricular (AV) nodal, His-Purkinje,"
DB01107,"Methyprylon, a piperidinedione CNS depressant, is close to barbituric acid in structure, but different enough to be called a ""non-barbiturate"" sedative-hynotic."
DB01429,Aprindine is a cardiac depressant used in arrhythmias
DB00336,Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem
DB08824,iodine-123 labeled ioflupanebinds selectively to striatal presynaptic dopamine neurons by binding reversibly to presynaptic dopamine transporters
DB09273,Doxofylline is a methylxanthine bronchodilator with potent bronchodilator activity comparable to that of theophylline.
DB06704,AdreView is a diagnostic radiopharmaceutical which contains a small quantity of iobenguane that is not expected to produce a pharmacodynamic effect
DB06794,Lodoxamide is a mast cell stabilizer that inhibits the in vivo Type 1 immediate hypersensitivity reaction
DB01084,Emedastine is a relatively selective H<sub>1</sub>-receptor antagonist
DB00920,Ketotifen is a non-competitive histamine antagonist and mast cell stabilizer.
DB00847,Cystine accumulation is the cause of organ damage in cystinosis.
DB01066,"Cefditoren pivoxil is a prodrug which is hydrolyzed by esterases during absorption,"
DB06626,Axitinib prevents the progression of cancer by inhibiting angiogenesis and blocking tumor growth
DB09079,Nintedanib is a small molecule kinase inhibitor that inhibits upstream kinase activity to ultimately inhibit lung fibroblast proliferation and migration
DB06637,Dalfampridine is a board-spectrum lipophillic potassium channel blocker and binds favourably to the open state than closed state of the potassium channel in the CNS
DB09414,Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues
DB09561,Glycerophosphate acts as a source of inorganic phosphate through hydrolysis 
DB09020,"Patients should be counselled regarding abdominal pain, nausea, vomiting, or a change in bowel function that lasts longer than 2 weeks."
DB08826,Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs
DB09268,"Sodium picosulfate is a stimulant laxative that in conjunction with magnesium citrate, produces a purgative effect on stools."
DB00471,Montelukast is a leukotriene receptor antagonist that demonstrates a marked affinity and selectivity to the cysteinyl leukotriene receptor type-1 in preference to many other crucial airway receptors like the prostanoid
DB01126,"Dutasteride is a synthetic 4-azasteroid compound that selectively inhibits both the type I and type II isoforms of steroid 5α-reductase,"
DB06155,"In the RIO-North America trial,"
DB09262,Imidafenacin is an antimuscarinic agent which acts to reduce the frequency of urination in patients with overactive bladder 
DB09143,Sonidegib has been shown to inhibit a transmembrane protein called SMO which plays a role in Hh signal transduction
DB08875,"Cabozantinib suppresses metastasis, angiogenesis,"
DB09061,"Although the exact mechanism and magnitude of effects of THC and CBD are not fully understood, CBD has been shown to have analgesic, anticonvulsant, muscle relaxant, anxiolytic, neuroprotective,"
DB05239,Cobimetinib is a reversible inhibitor of mitogen-activated protein kinase 1 (MAPK)/extracellular signal-regulated kinase 1 (MEK1) and MEK2
DB00799,"Following topical application, tazarotene undergoes esterase hydrolysis to form its active metabolite, tazarotenic acid."
DB03756,DHA in the central nervous system is found in the phospholipid bilayers where it modulates the physical environment and increase the free volume within the membrane bilayer
DB11560,Dose-dependent reductions in serum uric acid levels and increases in urinary uric acid excretion have been observed following single and multiple oral doses of lesinurad
DB06803,Niclosamide is an antihelminth used against tapeworm infections.
DB00640,Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy and also indicated for conversion of sinus rhythm of paroxysmal supraventricular tachycardia
DB06264,"Tolperisone is an oral, centrally acting muscle relaxant."
DB01303,Oxtriphylline is a bronchodilator.
DB13146,"Following intravenous administration, the tumor-to-normal tissue contrast is highest between 2 and 10 minutes after injection,"
DB09161,Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging
DB09293,The therapeutic effects of sodium iodide I-131 are a result of the ionizing radiation absorbed by the thyroidal tissue
DB01411,Pranlukast is a cysteinyl leukotriene receptor-1 antagonist
DB01048,Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
DB08957,Hexoprenaline is a stimulant of beta 2 adrenergic receptors.
DB03619,"Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine,"
DB05528,"Mipomersen sodium decreases the levels of apolipoprotein B (apo B), low density lipoprotein (LDL) non-high density lipoprotein-cholesterol,"
DB06213,Regadenoson rapidly increases coronary blood flow (CBF) which is sustained for a short duration
DB09269,Phenylacetic acid is an organic compound containing a phenyl functional group and a carboxylic acid functional group.
DB09067,"In normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma ACTH levels and a near parallel increase of plasma cortisol."
DB00115,"**General effects**Cyanocobalamin corrects vitamin B12 deficiency and improves the symptoms and laboratory abnormalities associated with pernicious anemia (megaloblastic indices, gastrointestinal lesions, and neurologic damage)."
DB06689,"When injected intravenously,"
DB13153,"Levomenol is an anti-inflammatory and natural moisturizing agent that has been found to diminish the signs of photodamage, reduce pruritus,"
DB08884,"Gadoxetate disodium is an amphipathic compound in which gadoxetate is hydrophillic and its moiety, the ethoxybenyzl group, is lipophillic."
DB04967,"Although lucanthone has structural and biochemical similarities to Actinomycin D, it has no hematological or gastro-intestinal toxicity at clinically tolerated doses."
DB06816,Pyrvinium is an anthelmintic agent which acts to kill pinworms 
DB11121,Chloroxylenol is a substituted phenol which has been widely used for many years as an ingredient of antiseptic and disinfectant products intended for external use 
DB04786,A polyanionic compound with an unknown mechanism of action
DB00711,Diethylcarbamazine is an anthelmintic drug that does not resemble other antiparasitic compounds
DB08974,Flubendazole is an anthelmintic that is used to treat worm infection in humans.
DB05630,The mode of action of sodium stibogluconate is not clearly understood
DB11254,"Hexylresorcinol is a phenol derivative,"
DB09277,Choline is phosphorylated by choline kinase into phosphorylcholine.
DB09125,Potassium citrate induces changes in the urine which renders urine less susceptible to the formation of crystals and stones from salts e.
DB09015,Canrenoic acid (as the salt potassium canrenoate) is an aldosterone antagonist.
DB13925,The overexpression of somatostatin recep
DB00236,Pipobroman is an antineoplastic agent.
DB09094,"Cell division is arrested and other cellular processes are impaired,"
DB00432,"Trifluridine exhibits an antiviral effect against herpes simplex virus,"
DB06193,"Pixantrone has a wide range of antitumor activity, especially in terms of treating leukemias and lymphomas ."
DB11793,Niraparib mediated cytotoxic effects in tumour cell lines with or without deficiencies in _BRCA1/2_
DB00548,"Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley."
DB00894,Testolactone is a synthetic anti-neoplastic agent that is structurally distinct from the androgen steroid nucleus in possessing a six-membered lactone ring in place of the usual five-membered carbocyclic D-ring
DB00791,Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA).
DB06243,Eflornithine is a prescription drug indicated in the treatment of facial hirsutism (excessive hair growth)
DB11231,"Lycopene is a naturally occuring red carotenoid pigment that is responsible in red to pink colors seen in tomatoes, pink grapefruit,"
DB01108,Trilostane blocks an enzyme involved in the production of several steroids including cortisol.
DB08913,"Physiologically, Radium Ra 223 Dichloride,"
DB00992,"After topical application of methyl aminolevulinate, porphyrins will accumulate intracellularly in the treated skin lesions."
DB09516,Mequinol is in fact considered a melanocytotoxic chemical which when oxidized in melanocytes results in the formation of toxic entities like quinones 
DB01579,"Phendimetrazine is a phenylalkylamine sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity,"
DB09069,Trimetazidine is indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies
DB09276,"Unknown,"
DB00513,Aminocaproic acid works as an antifibrinolytic.
DB09185,Viloxazine is a serotonin-norepinephrine modulating agent that has been used as a treatment for depression and Attention Deficit Hyperactivity Disorder (ADHD).
DB02959,The psychoactive action of 5-HTP is thought to be due to increased serotonin production in central nervous system tissue
DB09021,Benzoctamine acts as a sedative and axiolytic agent 
DB05245,Silver sulfadiazine has broad antimicrobial activity.
DB06150,"Sulfadimethoxine has been shown to be effective against streptococci, klebsiella, proteus, shigella, staphylococci, escherichia,"
DB00442,Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV).
DB00879,"Emtricitabine is a cytidine analog that competes with the natural substrate of HIV-1 reverse transcriptase to be incorporated into newly formed DNA,"
DB00581,Lactulose formulations are most commonly administered via the oral route or the rectal route.
DB01582,Sulfamethazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase).
DB00891,Sulfapyridine is a sulfonamide antibiotic.
DB04398,Lactic acid produces a metabolic alkalinizing effect
DB09221,Used to treat/manage peptic ulcer disease or irritation of the gastrointestinal tract by promoting tissue healing by the elimination of free radicals 
DB01378,"Magnesium hydroxide is used primarily in ""Milk of Magnesia"", a white aqueous,"
DB09087,"The presence of potassium alum reduces swollen mucous membranes that result from inflammation of the nasal,"
DB01413,Cefepime is a fourth-generation cephalosporin antibiotic.
DB00766,"Clavulanic acid inactivates some beta-lactamase enzymes that are produced by bacteria,"
DB08993,Cyclic basic peptide related to viomycin.
DB09154,Citrate prevents activation of the clotting cascade by chelating calcium ions.
DB00837,"Progabide, a fatty acid derivative,"
DB09137,Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to a technetium-99m ion.
DB00662,Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans.
DB08996,Little is known about the pharmacology of dimetacrine
DB00198,"There have been postmarketing reports of delirium and abnormal behavior leading to injury, and in some cases resulting in fatal outcomes,"
DB06804,Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide.
DB01599,Probucol lowers cholesterol levels by increasing LDL (low-density lipoprotein) breakdown.
DB00551,"Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea."
DB01553,"Cloxazolam, administered as a single oral dose of 3mg, when compared to a single 5 mg dose of diazepam in one study,"
DB09014,"Captodiame, also known as captodiamine, is an antihistamine which is used as a sedative and anxiolytic."
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