pmid string | section string | text string | annotations list |
|---|---|---|---|
37299942 | intro | 1. Introduction Children who experience handwriting learning disabilities may face significant negative effects on their academic success and daily life. Cognitive, visual perceptual and fine motor skills are essential for learning to write. Dysgraphia refers to the motor performance difficulties of handwriting rather ... | [
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38861157 | results | Results The anterodorsal thalamic nucleus shows early and consistent vulnerability to tau pathology We examined post-mortem brain samples from 26 cases, grouped by the Braak tau stages of disease progression (Table 1). We assessed early (Braak stages 0–II; n = 15), middle (Braak stages III–IV, n = 6), and late (Braak s... | [
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38447542 | intro | Introduction The World Health Organization (WHO) defines active aging as “the process of optimizing opportunities for health, participation and security in order to enhance quality of life as people age, allowing people to ‘realize their potential for physical, social and mental well-being throughout the life course.’”... | [
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38259745 | results | Results Between October 1st, 2019, and May 30th, 2022, 225 patients benefited from neuropsychological evaluations or cognitive training and were included in the analyzes (103 Female, mean age 71.53 ± 15.36 years). The patient’s population consisted in post-traumatic disorders (8%), post-stroke patients (23%) and dement... | [
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33101276 | abstract | The R47H variant in the microglial triggering receptor expressed on myeloid cell 2 (TREM2) receptor is a strong risk factor for Alzheimer's disease (AD). To characterize processes affected by R47H, we performed an integrative network analysis of genes expressed in brains of AD patients with R47H, sporadic AD without th... | [
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38594369 | title | Design and methods of the mobile assessment of cognition, environment, and sleep (MACES) feasibility study in newly diagnosed breast cancer patients | [
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82,
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39072940 | intro | INTRODUCTION Alzheimer's disease (AD) is a neurodegenerative disease affecting the brain with high incidence in the elderly. The typical clinical manifestations include progressive impairment or loss of cognitive function. Senile plaques formed by extracellular β‐amyloid (Aβ) deposition, and neurofibrillary tangles for... | [
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39131307 | abstract | Several age-related oral health problems have been associated with neurodegenerative diseases such as Alzheimer’s Disease (AD), yet how oromotor dysfunction in healthy aging differ from those found in pathological aging is still unknown. This is partly because changes in the cortical and biomechanical (“neuromechanical... | [
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38590779 | title | Role of autophagy in ischemic stroke: insights from animal models and preliminary evidence in the human disease | [
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98,
103
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] |
36348357 | title | ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies. | [
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0,
4
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39290562 | methods | Methods The systematic review was undertaken in accordance with the PRISMA criteria to ensure the reliability and comprehensiveness of the data and findings. The English databases searched included PubMed, Embase, the Cochrane Library, and the Web of Science and Scopus. The language used was English, according to the a... | [
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38813371 | intro | Introduction Mild cognitive impairment is a prodromal state of dementia that manifests with subtle balance control and gait deficits which may affect activities of daily living and contribute to the two folded increased risk of falls in this population. Consequences of these falls lead to reduced physical functioning, ... | [
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38079409 | results | Findings The findings present a narrative and charting of the data from the 45 papers that met the review criteria and this data is mapped onto the five objectives outlined in step one of the framework Within this review, interventions were grouped into five broad types: nature (n = 6 papers), memory/cognitive (n = 11 ... | [
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38334239 | intro | INTRODUCTION Parkinson's disease (PD) is a multifaceted neurodegenerative condition impacting upon many aspects of an individual's physical and psychological well‐being. PD is the second most common neurodegenerative disease, and the most common neurodegenerative movement disorder worldwide, with prevalence tending to ... | [
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38077459 | methods | 2 Materials and methods The trial was done in Osaka, Japan, and was based on approval from the Ethics Committee at the Graduate School of Engineering Science, Osaka University (approval code: 31-3-4). All participants agreed to place our robot at their homes, after a detailed description of the trial, and written conse... | [
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37230968 | intro | Introduction OSAS is a highly prevalent sleep-related breathing disorder characterized by hypopnea and apnea in ventilation. These breathing disturbances cause IH, which leads to blood hypoxemia, hypercapnia, fragmented sleep, recurrent nocturnal arousals, enhanced respiratory effort, and increased sympathetic nerve ac... | [
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34100423 | title | Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease. | [
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69,
88
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] |
37559139 | title | Enhanced activity of the left precuneus as a predictor of visuospatial dysfunction correlates with disease activity in rheumatoid arthritis | [] |
39215230 | methods | Methods Study design and registration The systematic review and meta-analyses followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines (Fig. 1) and is registered with the International Prospective Register of Systematic Reviews (XXX). Literature search strategy A systematic li... | [
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37546488 | methods | Methods This systematic review aimed to identify studies of MCI-related gaze behavior impairments published in the past 6 years (2017–2022). The protocol was drafted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Electronic databases (Edith Cowan University Library,... | [
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36965096 | title | Brain health registry updates: An online longitudinal neuroscience platform | [] |
36593415 | abstract | Generation of stable gene-edited plant lines using clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) requires a lengthy process of outcrossing to eliminate CRISPR-Cas9-associated sequences and produce transgene-free lines. We have addressed this issue by designing fus... | [
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38213645 | intro | Introduction The COVID-19 pandemic caused by the coronavirus named SARS-CoV-2 has significantly affected the economy and the business model (e.g., supply chain, consumer demands, sales and marketing) of almost all countries and territories. In fact, the COVID-19 pandemic has tremendously challenged organizations and co... | [
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37768921 | methods | Materials and methods Drosophila stock and culture D. melanogaster flies from the Canton S and w1118 (Stock #3605) strains were obtained from the Bloomington Stock Center, Indianapolis, IN. The group also used the GMR-GAL4 > UAS-Eiger stock kindly provided to our laboratory by Dr. Masayuki Miura of the University of To... | [
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37015625 | methods | Methods Kernel CCA To compute similarity between subjects, we utilize ideas from canonical correlation analysis (CCA). Conventional CCA seeks to find relationships between the features of two different views of a dataset. It aligns the two views, and , by finding canonical variables and that maximize the correlation... | [
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38564426 | methods | Materials and methods Sets of biomedical terms For the HPO, we took all the terms that have ‘phenotypic abnormality’ (HP:0000118) as an ancestor in the HPO hierarchy, in order to avoid terms not related to phenotypes or clinical signs, ending up in a final list of 16 218 terms From the DOID disease ontology, we retriev... | [
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38481598 | methods | Methods Following the guidelines in the Cochrane Handbook for Systematic Reviews of Interventions, we conducted this systematic review and meta-analysis. PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines were followed. Eligibility Criteria Included original research met the following... | [
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39188236 | results | Results Characteristics of the study participants In total, 22 individuals aged 65 years or older, with an average age of 75 years, living with HIV participated. Not all participants answered every question about demographics. We included a mixture of people, and overall, there was a geographic spread across Sweden, fr... | [
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37214931 | intro | INTRODUCTION Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors. BDNF is important in neuronal development and is also critical in the adult brain, where it supports neuronal structure and plasticity. One critical brain region where BDNF is high and has been studied extens... | [
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38077397 | title | The transcriptomics profiling of blood CD4 and CD8 T-cells in narcolepsy type I | [] |
38452202 | abstract | Supplemental Digital Content is Available in the Text. Abstract Understanding, measuring, and mitigating pain-related suffering is a key challenge for both clinical care and pain research. However, there is no consensus on what exactly the concept of pain-related suffering includes, and it is often not precisely operat... | [] |
38300977 | methods | Experimental design The protocol aims to improve motor and cognitive deficits in patients with Parkinsonian Syndromes. A clinical examination will verify the inclusion and exclusion criteria. The eligible subjects will be assessed, and outcome measures will be collected (t0) by a trained physiotherapist and psychologis... | [
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38961441 | results | Results The overall cohort’s demographic characteristics and plasma biomarker levels are presented in Table 1, and by center in Supp. Table 2. DLB and AD patients were significantly older than control individuals (P < 0.001). We observed a higher percentage of males in the DLB group than in the AD and control groups (P... | [
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38886941 | intro | Introduction The central nervous system (CNS) was previously considered an immune-privileged site owing to its ability to prevent inflammatory immune responses to antigens in the brain, in addition to limiting the exchange and access of cells and molecules from the periphery due to its highly specialized anatomical str... | [
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37754030 | intro | 1. Introduction Currently, over 55 million people worldwide are affected by dementia. It is a disease that constitutes ‘one of the main causes of incapability and dependency of older people’ as it interferes with normal daily functioning. Dementia is a syndrome caused by several diseases (e.g., tumors, metabolic disord... | [
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38840206 | abstract | Microglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but the underlying mechanisms and their contributions to neuroprotection versus neurodegeneration are unclear. Previous studies suggested that microglia are sex dimo... | [
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37396658 | title | The glymphatic system: a new perspective on brain diseases | [] |
38860032 | intro | 1 Introduction Robots in elderly care are increasingly targeted towards not only fulfilling practical needs, such as medication reminders or physical assistance, but also as companions to prevent and mediate loneliness through offering social and emotional support in their everyday lives, thus enhancing the psychologic... | [
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25058312 | title | Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride. | [
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39088385 | intro | Introduction Repeated sub-concussive head impacts are increasingly recognised to have detrimental effects on the brain. For instance, repeated sub-concussive head impacts negatively alter white matter tract integrity, reduce cortical thickness, and impair cognitive functions in both animals and humans. Although sub-con... | [
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35173173 | abstract | Early-onset familial Alzheimer’s disease (AD) is marked by an aggressive buildup of amyloid beta (Aβ) proteins, yet the neural circuit operations impacted during the initial stages of Aβ pathogenesis remain elusive. Here, we report a coding impairment of the medial entorhinal cortex (MEC) grid cell network in the J20 t... | [
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39360232 | abstract | Introduction The number of dementia patients is increasing with population aging. Preclinical detection of dementia in patients is essential for access to adequate treatment. In previous studies, dementia patients showed texture recognition difficulties. Onomatopoeia or sound symbolic words (SSW) are intuitively associ... | [
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38248857 | intro | 1. Introduction Blood analysis occupies a prominent part within the domains of clinical diagnostics and scientific research, particularly from the perspective of mass spectrometry (MS). Traditionally, the examination of human venous blood involves substantial volumes, often in the range of 100–200 mL, with adjustments ... | [
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2921,
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36189598 | abstract | BACKGROUND: DNA methylation is expected to become a kind of new diagnosis and treatment method of Alzheimer's disease (AD). Neuroinflammation- and immune-related pathways represent one of the major genetic risk factors for AD. OBJECTIVE: We aimed to investigate DNA methylation levels of 7 key immunologic-related genes ... | [
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39315314 | methods | METHODS Scoping review approach This review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta‐Analyses extension for Scoping Reviews (PRISMA‐ScR) guidelines, and research was guided by Arksey and O'Malley's scoping review framework. The review protocol was registered on PROS... | [
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39107774 | title | Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation | [
[
67,
71
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[
14,
18
]
] |
37954593 | results | Results Study subjects Sixty-five adults living with HIV-1 for a mean (SD) duration of 20.0 (8.0) years, were recruited at the University Hospitals of Nîmes and Montpellier, France. Eleven percent of them were females, and 89% males. Their mean age was 62.2 (4.0) years. They were of European, African, and Asian origin ... | [
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[
16536,
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[
17266,
... |
39188236 | title | Exploring experiences of ageing in older adults living with HIV in Sweden: a qualitative study | [] |
38774517 | title | Effect of time-restricted eating and intermittent fasting on cognitive function and mental health in older adults: A systematic review | [] |
38564243 | abstract | Background Both alcohol consumption and HIV infection are associated with worse brain, cognitive, and clinical outcomes in older adults. However, the extent to which brain and cognitive dysfunction is reversible with reduction or cessation of drinking is unknown. Objective The 30-Day Challenge study was designed to det... | [
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] |
39193914 | methods | Research Design and Methods Study Design and Population The UK Biobank is an ongoing longitudinal study including >500,000 adults between the ages of 40 and 70 from across the United Kingdom. Between 2006 and 2010, participants took part in a baseline examination at 1 of 22 assessment centers across the country consist... | [
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[
6623,
6635
],
[
7857,
7868
],
[
7985,
7990
],
[
8082,
8085
],
[
81... |
38328108 | abstract | Summary Men generally outperform women on encoding spatial components of episodic memory whereas the reverse holds for semantic elements. Here we show that female mice outperform males on tests for non-spatial aspects of episodic memory (“what”, “when”), suggesting that the human findings are influenced by neurobiologi... | [
[
119,
122
],
[
144,
149
],
[
274,
278
],
[
394,
399
],
[
634,
639
],
[
790,
796
],
[
939,
962
],
[
778,
781
],
[
878,
881
],
[
562,
565
],
[
784,
789
],
[
684,
689
],
[
... |
36883266 | abstract | Abstract Aim The molecular mechanism underlying Alzheimer's disease (AD) pathologies remains unclear. The brain is extremely sensitive to oxygen deprivation, and brief interruptions in oxygen supply may lead to permanent brain damage. The objective here was to access the red blood cell (RBC) physiological alterations a... | [
[
666,
670
],
[
644,
647
],
[
1356,
1360
],
[
1633,
1637
],
[
1675,
1679
],
[
1653,
1656
],
[
2102,
2106
]
] |
38466421 | intro | Introduction Patients with peripheral vestibular dysfunction (PVD) suffer from cognitive problems. Cognitive problems are present even in mild PVD and can persist long after a patient has clinically recovered. Several studies showed that patients with PVD have problems in spatial cognitive domains, such as spatial memo... | [
[
2200,
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[
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[
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[
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[
3368,
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[
3899,
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[
3955,
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[
3978,
3986
],
[
4370,
4378
],
[
4402,
4410
],
[
4615,
4623
],
[
46... |
38667317 | title | Lipidomic Analysis of Plasma Extracellular Vesicles Derived from Alzheimer’s Disease Patients | [] |
38642387 | methods | Method Study Design This was a cross-sectional analysis of baseline data collected from 262 older adults enrolled across three randomized controlled trials (RCTs) in our laboratory: (1) 96 from a study investigating the effects of a multidomain lifestyle program on sleep and cognition in older adults with MCI and poor ... | [
[
8946,
8958
],
[
8496,
8499
],
[
8345,
8348
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[
8173,
8176
],
[
9471,
9483
],
[
9866,
9878
],
[
11055,
11067
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[
11486,
11492
],
[
10903,
10906
],
[
10816,
10819
],
[
10731,
10734
],
... |
39193143 | methods | Materials and methods Study participants We informed patients about the study through the national registry for myotonic dystrophies.1 The inclusion criteria for the study were: (1) genetically confirmed diagnosis of DM1 or DM2; (2) age between 18 and 65 years; (3) presence of chronic muscle pain defined as persisting ... | [
[
5059,
5067
],
[
5783,
5791
],
[
5223,
5226
],
[
5230,
5233
],
[
5924,
5932
],
[
5962,
5974
],
[
6970,
6978
],
[
6832,
6835
],
[
6966,
6969
],
[
6877,
6880
],
[
7100,
7108
],
[
73... |
35305339 | title | Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study. | [
[
8,
13
],
[
80,
89
],
[
99,
118
]
] |
38490646 | title | Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease | [
[
129,
132
]
] |
39234240 | intro | Introduction Systemic sclerosis (SSc), an autoimmune condition primarily affecting women, is characterized by vascular dysfunction and progressive fibrosis of the skin and internal organs. The global incidence of SSc ranges between 8-56 new cases per million persons per year and the prevalence varies between 38-341 cas... | [
[
2510,
2515
],
[
2686,
2693
],
[
2762,
2769
],
[
2792,
2800
],
[
3776,
3784
],
[
4778,
4811
],
[
4813,
4819
],
[
4870,
4876
],
[
4883,
4928
],
[
4930,
4937
],
[
4975,
4979
],
[
50... |
32057951 | abstract | BACKGROUNDS: Recently, extensive evidence has indicated that the biological role of long non-coding RNAs (lncRNAs) in neurodegenerative diseases is becoming increasingly evident. The lncRNA brain-derived neurotrophic factor anti-sense (BDNF-AS) has been found to be dysregulated in Huntington's Disease. However, the fun... | [
[
233,
259
],
[
351,
358
],
[
397,
417
],
[
444,
451
],
[
455,
474
],
[
476,
478
],
[
560,
567
],
[
571,
573
],
[
628,
632
],
[
641,
646
],
[
656,
658
],
[
676,
683
],
[
... |
38141101 | methods | Methods Parent study It was a randomized, controlled, four-arm, parallel exercise and/or dietary intervention study (ClinicalTrials.gov: NCT03934476), with the primary aim of examining the VLCHF and HIIT effects on body composition and cardiorespiratory fitness (Cipryan et al.,). Data were collected in Ostrava, Czech R... | [
[
8571,
8583
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[
8667,
8679
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[
8360,
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],
[
9239,
9251
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[
9671,
9682
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[
9754,
9765
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[
9851,
9863
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[
10867,
10879
],
[
10947,
10959
],
[
11149,
11161
],
[
11256,
11268
],
... |
36014347 | title | Inhibition of Endoplasmic Reticulum Stress Improves Acetylcholine-Mediated Relaxation in the Aorta of Type-2 Diabetic Rats. | [
[
52,
65
],
[
102,
117
],
[
118,
122
]
] |
37132560 | intro | Introduction Dementia and mild cognitive impairment (MCI) are major neurocognitive disorders that pose remarkable health challenges worldwide. Dementia can be quite dehumanising in its advanced stages. Mild cognitive impairment occupies the intermediate stages in the continuum of cognition and is considered the leading... | [
[
3021,
3027
],
[
3869,
3877
],
[
4820,
4826
],
[
4981,
4988
],
[
5454,
5461
],
[
5519,
5525
]
] |
37052777 | intro | Inflammation specificities and factors involved The regulation of the inflammatory response remains a central aspect in the understanding of many pathological processes. The three phases that characterize inflammation, i.e., initiation, extension, and repair/resolution, are controlled by a large number of factors with ... | [
[
2263,
2276
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[
2312,
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[
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[
4168,
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[
4186,
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[
4307,
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[
4431,
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[
4455,
4460
],
[
4477,
4482
],
[
4577,
4582
],
[
48... |
37152359 | title | Computerised cognitive assessment in patients with traumatic brain injury: an observational study of feasibility and sensitivity relative to established clinical scales | [
[
37,
45
]
] |
38094513 | abstract | Age-related hearing loss (ARHL) is the most common cause of hearing loss and one of the most prevalent conditions affecting the elderly worldwide. Despite evidence from our lab and others about its polygenic nature, little is known about the specific genes, cell types, and pathways involved in ARHL, impeding the develo... | [
[
537,
542
],
[
581,
586
]
] |
39045493 | results | FINDINGS Overall, both older adults and family caregivers displayed similar behaviors and conversation preferences when designing VIPAs dialogues for behavioral activation. In this section, we focus on how users perceived VIPAs’ role in mental health intervention delivery through different levels of anthropomorphism di... | [
[
29141,
29153
],
[
29311,
29323
],
[
29677,
29689
],
[
29965,
29977
],
[
30107,
30119
],
[
30601,
30613
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[
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30759
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[
30904,
30916
],
[
31588,
31600
],
[
31672,
31684
],
[
31736,
... |
38426052 | abstract | Background Currently, there has been observed a significant alteration in the composition of the gut microbiome (GM) and serum metabolites in patients with psoriatic arthritis (PsA) compared to healthy individuals. However, previous observational studies have shown inconsistent results regarding the alteration of gut m... | [
[
223,
237
],
[
268,
276
],
[
596,
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[
303,
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[
761,
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[
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[
2316,
2320
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[
1454,
1457
],
[
1919,
1922
],
[
1734,
1737... |
39007039 | abstract | Abstract The frequency of the apolipoprotein E ɛ4 allele and vascular risk factors differs among ethnic groups. We aimed to assess the combined effects of apolipoprotein E ɛ4 and vascular risk factors on brain age in Korean and UK cognitively unimpaired populations. We also aimed to determine the differences in the com... | [
[
141,
157
],
[
267,
287
],
[
708,
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],
[
874,
894
],
[
1042,
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[
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[
1465,
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[
1651,
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],
[
1885,
1901
],
[
2047,
2067
],
[
1962,
1965
],
[
1742,
... |
38839833 | methods | Materials and methods Participants We performed a prospective evaluation of patients referred to the Alzheimer’s disease and other Cognitive Disorders Unit of the Neurology Service at the Hospital Clínic de Barcelona, Barcelona, Spain. Participants were consecutively recruited between March 2021 and November 2021. Incl... | [
[
5719,
5727
],
[
5882,
5894
],
[
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6188
],
[
6430,
6442
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[
6979,
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],
[
7179,
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[
7262,
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],
[
7441,
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],
[
8573,
8585
],
[
9214,
9218
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[
9902,
9905
],
[
10... |
38863019 | intro | Background Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) and tau deposition. Neuronal injury, neuroinflammation and vascular disease also play a crucial role in the pathogenesis of AD. Cerebral small vessel disease (CSVD) is characterized by extensive white matter hyperintensities (WMH). Pathological s... | [
[
3113,
3121
],
[
2586,
2595
],
[
2601,
2604
],
[
3026,
3029
],
[
4603,
4611
],
[
3833,
3836
],
[
5547,
5550
]
] |
33519418 | abstract | Background: Mild cognitive impairment (MCI) is an early stage of Alzheimer's disease. Repetitive transcranial magnetic stimulation (rTMS) has been widely employed in MCI research. However, there is no reliable systematic evidence regarding the effects of rTMS on MCI. The aim of this review was to evaluate the efficacy ... | [
[
959,
967
],
[
1944,
1952
],
[
2191,
2199
]
] |
38865281 | results | RESULTS Baseline demographics were compared between patients with and without DM before and after PSM. After PSM, balance between the two groups was achieved for all variables (Table 1). Regarding the conversion from MCI to AD, Kaplan–Meier survival curves did not show statistical significance (P = 0.28) between patien... | [
[
14310,
14318
],
[
14367,
14370
],
[
14356,
14359
],
[
15796,
15804
],
[
15957,
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],
[
15979,
15987
],
[
16183,
16191
],
[
16216,
16224
],
[
16339,
16347
],
[
16420,
16428
],
[
16416,
... |
38780713 | title | The impact of the Mediterranean diet on immune function in older adults | [] |
37071459 | methods | Methods Review Methodology This scoping review of systematic reviews was guided by the methodological framework of the Joanna Briggs Institute. The study selection followed the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) flow diagram, and the reporting and mapping of the body of literatur... | [
[
9680,
9716
]
] |
37122378 | methods | Method and materials Study design and subjects From May 2021 to August 2022, 139 patients with PD were recruited from Beijing Tiantan Hospital, Capital Medical University. All PD patients met the International Parkinson and Movement Disorder Society Clinical Diagnostic Criteria. The severity of cognitive impairment was... | [
[
5818,
5872
],
[
6071,
6149
],
[
6221,
6224
],
[
6303,
6319
],
[
6535,
6552
],
[
6681,
6702
],
[
6713,
6734
],
[
6736,
6759
],
[
6783,
6815
],
[
6834,
6839
],
[
6869,
6872
],
[
69... |
39116421 | title | A Review of the Role of Estrogens in Olfaction, Sleep and Glymphatic Functionality in Relation to Sex Disparity in Alzheimer’s Disease | [] |
34307303 | title | Co-Immobilized Capillary Enzyme Reactor Based on Beta-Secretase1 and Acetylcholinesterase: A Model for Dual-Ligand Screening. | [
[
49,
64
],
[
69,
89
]
] |
39238777 | intro | Introduction The aging population has been increasing globally at an unprecedented rate. A recent report from the World Health Organization projected that one in six people worldwide will be aged 60 years or older by 2030. Among the significant concerns associated with aging are the risks of neurodegenerative condition... | [
[
2014,
2020
],
[
4609,
4621
],
[
4657,
4669
],
[
5573,
5585
],
[
7779,
7791
],
[
10507,
10513
],
[
10543,
10549
],
[
19567,
19579
]
] |
38743119 | title | The Role of Beta2-Microglobulin in Central Nervous System Disease | [
[
12,
31
]
] |
33418848 | title | Tau Oligomers Neurotoxicity. | [
[
0,
3
],
[
14,
27
]
] |
37143686 | methods | Methods Study design and participants This case control cross sectional study was part of another study that primarily aimed at determining the impacts of schistosomiasis on the early childhood development that was conducted in Murewa, Zimbabwe. The main objective of the study was to determine the role of systemic infl... | [
[
7162,
7176
],
[
7220,
7234
],
[
7698,
7712
],
[
7766,
7776
],
[
7857,
7865
],
[
8102,
8112
],
[
8360,
8374
],
[
8407,
8417
],
[
8594,
8608
],
[
8655,
8665
],
[
8825,
8830
],
[
96... |
39356504 | methods | Methods This cohort study was approved by the University of New South Wales human research ethics committee. Each study had independent approval from its regional ethics board, and their participants provided informed consent. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting g... | [
[
4834,
4839
],
[
4945,
4957
],
[
5457,
5469
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[
8366,
8382
],
[
8395,
8400
],
[
12112,
12124
],
[
12588,
12600
],
[
13487,
13499
],
[
13923,
13935
],
[
14902,
14914
]
] |
38941274 | title | TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons | [
[
0,
7
],
[
20,
23
],
[
86,
89
]
] |
36963989 | results | Cardiovascular findings Although ME/CFS is not considered as a primary cardiovascular disorder, there are certainly indications of cardiovascular dysfunction in this disease population. ME/CFS individuals exhibit an increased risk for premature heart failure and earlier all-cause mortality, as do Long COVID suffers. Th... | [
[
9583,
9606
],
[
9643,
9669
],
[
9757,
9770
],
[
9880,
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[
9957,
9959
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[
10089,
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[
10469,
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[
10477,
10490
],
[
10495,
10498
],
[
10635,
10669
],
[
10762,
10775
]... |
37370560 | title | A New Breakpoint to Classify 3D Voxels in MRI: A Space Transform Strategy with 3t2FTS-v2 and Its Application for ResNet50-Based Categorization of Brain Tumors | [] |
38961406 | results | Results The analysis included 607 participants [age: 65.99 ± 8.79 years, females: 363 (59.80%); HCs, n = 110; MCI, n = 269; and AD dementia, n = 228]. Of the 497 patients on the AD continuum, 138 (27.77%) underwent lumbar puncture for CSF hallmark testing (MCI, n = 33; AD dementia, n = 105). Table 1 presents the partic... | [
[
19145,
19157
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[
19290,
19298
],
[
19451,
19463
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[
19541,
19549
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[
19628,
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[
19768,
19776
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[
19733,
19736
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[
19599,
19602
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[
19584,
19587
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[
19490,
19493
],
[
19363,
... |
38474961 | methods | 2. Methodology 2.1. Experimental Protocol 2.1.1. Study Design A randomized controlled, within-participant, crossover design was used to examine the effects of four conditions—silence, self-selected favorite music, negative feedback, and positive feedback—on moods, individual muscle firing patterns, and motor coordinati... | [
[
5491,
5502
],
[
5747,
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[
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[
5879,
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[
6002,
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[
5770,
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[
6095,
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[
6342,
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],
[
6459,
6471
],
[
6602,
6614
],
[
7289,
7301
],
[
73... |
31581969 | results | Results Comparison of “fully normal cognition” to “not-fully normal cognition” (group 1 versus group 2) showed that memory, executive function, and attention domains significantly differed between these cognitively normal subgroups (Table 1). The 3-cluster solution yielded the highest number of significant differences ... | [] |
32922516 | title | Gender issues of antibody-mediated diseases in neurology: (NMOSD/autoimmune encephalitis/MG). | [
[
17,
43
],
[
59,
64
],
[
65,
88
],
[
89,
91
]
] |
38913044 | results | RESULTS Increased body weight, serum glucose and insulin, lipids, and liver enzymes in OVX-mice fed a high fat-sugar-salt diet Body weight increased in the OVX-Diet group relative to the control mice (p<0.0001). Weight over time increased in both groups, yet in the OVX-Diet, from week ten onwards, the increase was much... | [
[
20945,
20949
],
[
21049,
21053
],
[
21284,
21288
],
[
21343,
21347
],
[
21488,
21492
],
[
21517,
21521
],
[
21840,
21844
],
[
21916,
21920
],
[
22057,
22061
],
[
22086,
22090
],
[
22372,
... |
39193143 | methods | Materials and methods Study participants We informed patients about the study through the national registry for myotonic dystrophies.1 The inclusion criteria for the study were: (1) genetically confirmed diagnosis of DM1 or DM2; (2) age between 18 and 65 years; (3) presence of chronic muscle pain defined as persisting ... | [
[
5059,
5067
],
[
5783,
5791
],
[
5223,
5226
],
[
5230,
5233
],
[
5924,
5932
],
[
5962,
5974
],
[
6970,
6978
],
[
6832,
6835
],
[
6966,
6969
],
[
6877,
6880
],
[
7100,
7108
],
[
73... |
38298786 | methods | Methods and Materials Participants Magnetic resonance imaging (MRI) data were acquired in the context of an ongoing clinical trial called PACt-MD (Prevention of Alzheimer’s Dementia With Cognitive Remediation Plus Transcranial Direct Current Stimulation in Mild Cognitive Impairment and Depression), which was approved b... | [
[
5841,
5853
],
[
6018,
6030
],
[
6760,
6772
],
[
6994,
7006
],
[
7082,
7087
],
[
9792,
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],
[
9856,
9868
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[
9902,
9914
],
[
9957,
9969
],
[
10348,
10360
],
[
10441,
10453
],
[
... |
37236657 | results | Results The participant sample had a mean age of 51.20 years (SD=5.44), and 61.65% of the participants were female. Baseline participant characteristics are presented in table 1. Pairwise correlations A pairwise correlation with Bonferroni correction was conducted and showed few significant associations between the cog... | [
[
13720,
13731
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[
13798,
13810
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[
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[
14845,
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[
15021,
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[
15097,
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[
15186,
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[
15329,
15336
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[
15698,
15705
],
[
15772,
15779
],
[
16172,
... |
37643838 | abstract | [] | |
39237554 | methods | Methods Participants Thirty-one individuals with the FMR1 premutation (21M, 10F) completed a
five-minute monologue as an optional component of a larger study at the University
of California-Davis (PI: Hagerman) that included cognitive, neuropsychological, and
medical asse... | [
[
10349,
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[
10402,
10414
],
[
10455,
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[
10621,
10632
],
[
10722,
10734
],
[
10885,
10897
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[
10063,
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[
10573,
10577
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[
10372,
10375
],
[
11075,
11087
],
[
11358,
... |
39150412 | abstract | During the last decade, there has been a move towards consumer-centric hearing healthcare. This is a direct result of technological advancements (e.g., merger of consumer grade hearing aids with consumer grade earphones creating a wide range of hearing devices) as well as policy changes (e.g., the U.S. Food and Drug Ad... | [
[
855,
861
],
[
461,
464
],
[
1102,
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[
474,
477
]
] |
38071284 | intro | Background Neurodegenerative disorders like dementia are on the rise in sub–Saharan Africa due to increased longevity leading to an increase in the numbers of older people. In response, memory clinics have been established in some parts of sub-Saharan Africa to identify, investigate, and treat cognitive disorders such ... | [
[
2993,
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[
3219,
3227
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[
3282,
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[
3352,
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[
3487,
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[
3601,
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[
4302,
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[
4839,
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[
5243,
5251
],
[
6046,
6052
],
[
6356,
6363
],
[
64... |
39309765 | title | Interactions of memantine and rivastigmine with graphene oxide nanocarrier and beta-amyloid protein using molecular docking and in-silico methods | [] |
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