text stringlengths 98 918 | conversation_id int64 22.6k 77.2k | embedding list | cluster int64 9 9 |
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Answer this question truthfully
The power of a study is increased with increased expected effect size.
What is the relationship between the expected effect size and the power of a study?
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A muscle strength evaluation of 4/5 indicates some movement against resistance.
What does a muscle strength evaluation of 4/5 indicate?
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A muscle strength evaluation of 3/5 indicates movement against gravity, but not resistance.
What does a muscle strength evaluation of 3/5 indicate?
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A muscle strength evaluation of 2/5 indicates movement, but not against gravity.
What does a muscle strength evaluation of 2/5 indicate?
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A muscle strength evaluation of 1/5 indicates muscle flicker, but no movement.
What does a muscle strength evaluation of 1/5 indicate?
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There is a minimal difference between probability and odds when the probability value is small, such as less than 10%. In such cases, the difference between the two measures is generally negligible and may not have a significant impact on the interpretation of the data. However, as the p... | 32,451 | [
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What do different values of the area under the curve (AUC) indicate for an ROC curve? An AUC of 0.5 indicates a bad test, while an AUC of 1.0 indicates a good test.
What do different values of the area under the curve (AUC) indicate for an ROC curve?
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Conditions for which there is conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of a procedure or treatment.
Weight of evidence/opinion is in favor of usefulness/efficacy.
Usefulness/efficacy is less well established by evidence/opinion.
What is the proper... | 47,630 | [
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Answer this question truthfully
View the Current Guidelines
Click here to comment on this section of the current guidelines
Make your voice heard: Vote to upgrade, downgrade or keep a recommendation the same
Suggest Revisions to the Guidelines
What is the appropriate treatment for...?
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Answer this question truthfully
There is insufficient evidence to recommend routine screening for heart failure.
Can you provide a summary of congestive heart failure?
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Answer this question truthfully
Quality of Evidence
Strength of Recommendation
The strength of recommendation is determined based on a benefit vs. cost/risk to patient.
According to ACG, what is the classification scheme for guidelines?
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
As we have previously shown an additional effect of vibrating insoles on improving static balance [3–5], it is possible that the combined effect on balance and gait will have a greater impact on falls and mobility than our data would i... | 68,516 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Furthermore, gut microbiota analysis in mice treated with hypolipidemic drugs revealed a modification in composition in favor of probiotic-type bacteria from Lactobacillus spp. [49].
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Further research is recommended that may be helpful in establishing the direction of the association.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Further study will be necessary to test if postnatal intervention can effectively promote neurodevelopmental outcomes for healthy infants with below-average white matter development at birth.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Interestingly, within this context, it has been proposed that environmental enrichment itself may actually be a mild stressor in mice (Moncek et al 2004).
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Thus, a failed quit or reduction attempt is a marker of increased, not decreased, interest in changing.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
This study replicates our prior findings (Hughes et al, 2008) that a) cannabis users trying to change make many, and often rapid, transitions among use as usual, reduction and abstinence states; b) reduction attempts are more common th... | 68,523 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
While the use of a cross-sectional design limits ascertainment of direction of association (i.e. it is possible that mindfulness strategies may change after the symptoms of social anxiety disappear), strengthened mindfulness strategies... | 68,524 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
This allowed the majority of transplants performed for these patients (189 of 247, 76%) to use a KIR typed donor.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Furthermore, the PEEP titration intervals were small (2 cm H2O), which was more accurate and might help identify slight changes.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Since total cortisol concentrations under the intravenous cortisol clamps were comparable in the men and women, and calculated free cortisol levels were actually lower in women, a straightforward hypothesis is that E2 may mediate enhan... | 68,528 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
In contrast, the study conducted by Jain et.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Short-acting opioids are used for immediate management of breakthrough pain and even NP episodes (in the context of an anticonvulsant and/or TCA regimen) (Eisenberg, McNicol, & Carr, 2005).
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The underlying question in most prayer studies is ‘does prayer influence health’.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The existence and phenotype of MICs was first reported in the peripheral blood of primary human luminal breast cancer using a xenograft assay 30.
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This is no advice
In the B/H24 sublineage, the introduction of the fluoroquinolone resistance by mutations in gyrA and parC (B2/H24R) and the introduction of blaCTX-M-15 (B3/H24Rx) were also estimated to have occurred around 1987 concurrently with the w... | 68,533 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Given this, further studies on reduction as a treatment goal are needed.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Several constructive recommendations for the private and public sectors can be drawn from this investigation.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Thus, different mechanisms of liver fibrogenesis and carcinogenesis might operate in HBV- and HCV-related chronic inflammation.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
However, we did not distinguish between short and long daytime nap duration, which remains to be elucidated in further studies.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Possibly, these patients had been severely restricted in their quality of life before the operation as a result of the discomfort of the spondylitis.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Finally, the cross-sectional design limits our study, and these limits are especially noteworthy in prayer research.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Especially in the setting of sepsis it is the main reason for multiorgan failure and increased mortality 19.
| 68,540 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Thus, it is difficult to make a clear statement about possible different effects as a consequence of macronutrient restriction.
| 68,541 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Imaging studies have shown that approximately 100% of patients have abnormal shape in their bilateral or (and) unilateral adrenal gland, but these have different anatomic abnormality (adenomas, hyperplasia, tubercle).
| 68,542 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
An alteration in the regulation of cytokines may negatively affect the mechanism of host defense and render the host vulnerable.
| 68,543 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Hydration with bicarbonate for prophylaxis of CIN has been investigated in more than 20 clinical trials with heterogeneous but mostly positive effects 16,27.
| 68,545 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Depending on the degree to which these elements congregate, a wide range of phenotypes arises.
| 68,546 | [
0.3125,
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The results of this 3-year, cluster-randomized controlled, longitudinal efficacy study have implications for practice, policy, and research.
| 68,547 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Our findings may differ from this prior study because periods of abstinence in our study were very short.
| 68,548 | [
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-0.54... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The main message of these last studies was that transsexuals showed no evidence of psychopathology according to the MMPI-2 profile, and transsexualism can exist independent of other psychopathology.
| 68,549 | [
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-0... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
While amblyopia has a prevalence during childhood of approximately 2%,31–33 the prevalence of risk factors for amblyopia are much higher at 15 to 20%,34–37 leading to the likelihood of over-referral.
| 68,550 | [
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... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The impact on obesity status in adult carriers appears less pronounced, but there is nevertheless an appreciable increase in BMI (corresponding to 15–19 kg in weight for subjects 160–180 cm in height).
| 68,551 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
From this study, the proportion of EHs involved higher difference than the PHs in Family heredity ,however, we defined any history of familial hypertension as Family heredity ascribed to the posterior awareness of primary aldosteronism... | 68,552 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The shorter scan time has potential to improve spatial resolution and reduce image artifacts caused by increased motion instability during the long scan time [13, 15].
| 68,553 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The majority of the 127 international ST410 isolates in our study were collected from humans (119/127); however, eight isolates were from nonhuman sources.
| 68,554 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Animal and human models underline that tubular epithelial cells are susceptible to apoptosis and injury may contribute to organ failure [19, 20].
| 68,555 | [
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... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
In this study, people with a family history of CHD and GT/TT genotype of rs1130214 or AG/GG genotype of rs3803300 were easily attacked by CHD.
| 68,556 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Second, our study design was cross-sectional, the associations causality need cohort studies with follow-up data to strengthen the understanding.
| 68,557 | [
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-0.... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Obviously, diet is an important factor determining the composition of the gut microbiota.
| 68,558 | [
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... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
However, it would seem that object knowledge is an experientially acquired faculty that should be tested with items that the subject has used and encountered frequently, not with items that may predominantly elicit encyclopaedic, and t... | 68,559 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
This biker position was initially developed as an equivalent to the prone position adapted to the particular geometry of the D.SPECT camera, for which image recording in the prone position may not be proposed.
| 68,560 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
These findings are consistent with previous work by Lisco et al reporting increased compartmentalization of many proinflammatory cytokines in the setting of HIV-1 infection18.
| 68,561 | [
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... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
In the past, stress exposures of various durations have been associated with a decrease in synapses and neuropil in fronto-limbic cortical areas (Andersen & Teicher, 2004; Gos et al, 2008; Huot, Plotsky, Lenox, & McNamara, 2002).
| 68,562 | [
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... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
First, a potential disadvantage was the relatively small sample size in the present study, an epidemiological investigation with larger sample size is needed to verify the results in the future.
| 68,563 | [
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... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The potential for selection bias is acknowledged.
| 68,564 | [
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... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Strengths and limitations Regarding strengths, the study was a thoroughly executed, randomized controlled trial following the CONSORT statement.
| 68,565 | [
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-0.5,
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Similar ethnic differences in rapid BMI gain trajectories have also been reported between African-American and white children in the U.S12.
| 68,566 | [
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-0.7... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Comparative data are needed to determine if the acute sensitivity of growth to immune function and other energetic stressors is unique to humans or is more widely characteristic of large-brained primates.
| 68,567 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Several studies have identified that a loss of Dicer contributes to tumorigenesis progression via DNA damage69,70.
| 68,568 | [
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... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
These observations are consistent with our prior findings that local factors such as sphingolipid-related enzymes are a key mediator of danger signaling in podocytes irrespectively of the level of circulating factors (43).
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The pre-study sample size projection was based upon estimates that 70% of searches would KIR genotype 5 or more donors and 30% would type 3 donors.
| 68,570 | [
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0.0112380... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is a weak advice
Thus, CMRA offers a relatively safe tool for the evaluation of the cardiac venous anatomy.
| 68,571 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Given that these exposures occur at the periods when the epigenetic signature is more plastic, they might also lead to aberrant DNA methylation changes which will be inherited during cell divisions and be detectable years later.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
People are also exposed to food environments as they go about their daily activities (e.g. during travel and at work), although we were unable to measure these exposures.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Most EV-D68 cases were identified from hospitals, which may have overestimated the severity of infection, with only severe cases being hospitalised, and also biased findings towards child cases.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Other factors that compromise neuromuscular transmission in previously recognized congenital myasthenic syndromes, e.g., decrease of evoked quantal release, diminished expression of AChE or AChR, a kinetic defect in AChR, or alteration... | 68,576 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Instead, environmental exposures at the periods of developmental plasticity are likely to be the cause of the dramatic decrease in age at menarche.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Several studies have explored the deregulation of DICER1, which is required for miRNA processing, as part of CRC etiology.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Forty genes were associated (p<0.05) with risk of breast cancer in the Mayo Clinic population.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Furthermore, Romero et al. [27] and Yoon et al. [11] reported that IL-6 concentration in amniotic fluid is a more sensitive measure for predicting intrauterine inflammation than gram staining, the glucose concentration, or the white bl... | 68,580 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Moreover, while HLM analyses were used to study inter-individual and intra-individual differences, other areas of interest include the examination of higher, house-level predictors (i.e., social climate, ethnic composition of a house) ... | 68,581 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
One potential source identified was straw board in walls and ceilings disturbed by the renovation work.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
When correlating echogenicity with tissue pathology in rats, Tabel et al20 demonstrated hyperechoic tissue only within older infarcts where thick collagen fibers were present.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The inhibition of the enzyme MTHFR is responsible for the increas in homocystein level.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
SNPs in the 3′-UTR have been reported to contribute to the regulation of transcript stabilization48.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
This may have resulted in a dilution of the effects of food environment on cardiovascular risk factors.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The main aim of this trial was to investigate whether the effi - cacy—evaluated by improvement in patient-reported outcome—was better in patients who underwent THA with PA rather than THA with LA, 12 months postoperatively.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
We demonstrate significant associations between seminal plasma IFN-γ, IL-17, and IL-5 and seminal plasma HIV-1 RNA levels.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Li et al summarize multiple populations of others researchers to analyze the association of the common polymorphism C667T in methylenetetrahydrofolate reductase gene with CHD risk, the results indicate that methylenetetrahydrofolate re... | 68,591 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
BMD and fracture risk are determined both by environmental and genetic factors.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Because of the large number of genes and SNPs assessed in this relatively small sample, we had limited statistical power to detect significant associations.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Earlier, in a study conducted among 638 elderly Spanish individuals with a high risk for cardiovascular diseases, eating competence was associated with a lower risk of IFG [10].
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The significant decrease in the symptom score and in the level of specific IgE against Par j 2 also pointed to good clinical efficacy of the vaccine.
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... | 9 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
We have demonstrated that the effects of specific forms of immune activity on growth are consistent with expected energy use and transpire across a wide range of timeframes.
| 68,596 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
We annotated only the most significant SNPs that met a stringent P value threshold for significance (typically 5 × 10−8) to adjust for multiple testing problems in a single-SNP approach.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
This could be due to the mice experiencing a mild “enrichment effect” as consequence of out maternal separation protocol and subsequent changes in maternal care, or, as adults, due to behavioral testing in the Open Field Object Recogni... | 68,598 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Therefore longer sleep duration could be a subtle marker of the disease, rather than as a cause of stroke.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Recent experimental evidence suggests that local TNF causes inflammasome activation (51) and is associated with altered cholesterol homeostasis (52).
| 68,600 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Several previous studies have described the psychological testing of transsexuals.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
However, both of the two GWASs were performed in LC patients developed from chronic hepatitis C. Till present, no GWAS has been conducted to systematically identify genetic variants associated with HBV-related LC.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Contaminated straw board represents a potential source of Q fever and should be considered in future outbreak investigations.
| 68,603 | [
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is a strong advice
Pharmacological therapies should be supplemented by multidisciplinary approaches such as physical therapy and psychological interventions.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
The potential circulating factors in FSGS that may affect glomerular TNF expression remain to be identified.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Males generally had significantly larger dental arch measurements than females.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Recruited participants in this study were patients attending OHC.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
(Chong et al, 2002; Lee., 2003) In the present sutdy, only 16% of the health care professionals were performing BSE.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
To avoid the risk of comparing surgeon skills or surgeon preference rather than the surgical procedure, 3 equally experienced surgeons participated in each team.
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
This is no advice
Paracetamol (also known as acetaminophen) was the most commonly used analgesic by patients with dental pain in this study.
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